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Search of human proteins with 187173292
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|187173292 troponin T1, skeletal, slow isoform c [Homo
sapiens]
(251 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|187173292 troponin T1, skeletal, slow isoform c [Homo sapiens] 499 e-141
gi|187173290 troponin T1, skeletal, slow isoform b [Homo sapiens] 490 e-139
gi|187173288 troponin T1, skeletal, slow isoform a [Homo sapiens] 480 e-136
gi|112789541 troponin T3, skeletal, fast isoform 4 [Homo sapiens] 325 2e-89
gi|5803203 troponin T3, skeletal, fast isoform 1 [Homo sapiens] 321 4e-88
gi|112789538 troponin T3, skeletal, fast isoform 2 [Homo sapiens] 320 7e-88
gi|48255881 troponin T type 2, cardiac isoform 3 [Homo sapiens] 318 2e-87
gi|48255877 troponin T type 2, cardiac isoform 1 [Homo sapiens] 318 2e-87
gi|112789536 troponin T3, skeletal, fast isoform 3 [Homo sapiens] 318 3e-87
gi|48255883 troponin T type 2, cardiac isoform 4 [Homo sapiens] 315 2e-86
gi|48255879 troponin T type 2, cardiac isoform 2 [Homo sapiens] 313 9e-86
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 71 8e-13
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 71 8e-13
gi|148746195 trichohyalin [Homo sapiens] 67 2e-11
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 60 2e-09
gi|92859701 myosin VI [Homo sapiens] 60 2e-09
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 60 2e-09
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 60 2e-09
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 59 3e-09
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens] 59 4e-09
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 58 7e-09
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 58 9e-09
gi|56549694 enabled homolog isoform a [Homo sapiens] 57 2e-08
gi|39930375 enabled homolog isoform b [Homo sapiens] 57 2e-08
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap... 57 2e-08
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap... 57 2e-08
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap... 57 2e-08
gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapi... 57 2e-08
gi|55741709 RNA binding motif protein 25 [Homo sapiens] 56 3e-08
gi|4503509 eukaryotic translation initiation factor 3, subunit 1... 56 3e-08
>gi|187173292 troponin T1, skeletal, slow isoform c [Homo sapiens]
Length = 251
Score = 499 bits (1284), Expect = e-141
Identities = 251/251 (100%), Positives = 251/251 (100%)
Query: 1 MSDTEEQEYEEEQPEEEAAEEEEEEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRM 60
MSDTEEQEYEEEQPEEEAAEEEEEEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRM
Sbjct: 1 MSDTEEQEYEEEQPEEEAAEEEEEEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRM 60
Query: 61 EKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAKLAEE 120
EKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAKLAEE
Sbjct: 61 EKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAKLAEE 120
Query: 121 KMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERKK 180
KMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERKK
Sbjct: 121 KMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERKK 180
Query: 181 PLDIDYMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYNRISHAQKFRKG 240
PLDIDYMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYNRISHAQKFRKG
Sbjct: 181 PLDIDYMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYNRISHAQKFRKG 240
Query: 241 AGKGRVGGRWK 251
AGKGRVGGRWK
Sbjct: 241 AGKGRVGGRWK 251
>gi|187173290 troponin T1, skeletal, slow isoform b [Homo sapiens]
Length = 262
Score = 490 bits (1262), Expect = e-139
Identities = 251/262 (95%), Positives = 251/262 (95%), Gaps = 11/262 (4%)
Query: 1 MSDTEEQEYEEEQPEEEAAEEEEE-----------EEERPKPSRPVVPPLIPPKIPEGER 49
MSDTEEQEYEEEQPEEEAAEEEEE EEERPKPSRPVVPPLIPPKIPEGER
Sbjct: 1 MSDTEEQEYEEEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGER 60
Query: 50 VDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEK 109
VDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEK
Sbjct: 61 VDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEK 120
Query: 110 ERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGRE 169
ERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGRE
Sbjct: 121 ERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGRE 180
Query: 170 MKVRILSERKKPLDIDYMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYN 229
MKVRILSERKKPLDIDYMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYN
Sbjct: 181 MKVRILSERKKPLDIDYMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYN 240
Query: 230 RISHAQKFRKGAGKGRVGGRWK 251
RISHAQKFRKGAGKGRVGGRWK
Sbjct: 241 RISHAQKFRKGAGKGRVGGRWK 262
>gi|187173288 troponin T1, skeletal, slow isoform a [Homo sapiens]
Length = 278
Score = 480 bits (1235), Expect = e-136
Identities = 251/278 (90%), Positives = 251/278 (90%), Gaps = 27/278 (9%)
Query: 1 MSDTEEQEYEEEQPEEEAAEEEEE-----------EEERPKPSRPVVPPLIPPKIPEGER 49
MSDTEEQEYEEEQPEEEAAEEEEE EEERPKPSRPVVPPLIPPKIPEGER
Sbjct: 1 MSDTEEQEYEEEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGER 60
Query: 50 VDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEK 109
VDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEK
Sbjct: 61 VDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEK 120
Query: 110 ERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGRE 169
ERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGRE
Sbjct: 121 ERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGRE 180
Query: 170 MKVRILSERKKPLDIDYMGEEQL----------------REKAQELSDWIHQLESEKFDL 213
MKVRILSERKKPLDIDYMGEEQL REKAQELSDWIHQLESEKFDL
Sbjct: 181 MKVRILSERKKPLDIDYMGEEQLRARSAWLPPSQPSCPAREKAQELSDWIHQLESEKFDL 240
Query: 214 MAKLKQQKYEINVLYNRISHAQKFRKGAGKGRVGGRWK 251
MAKLKQQKYEINVLYNRISHAQKFRKGAGKGRVGGRWK
Sbjct: 241 MAKLKQQKYEINVLYNRISHAQKFRKGAGKGRVGGRWK 278
>gi|112789541 troponin T3, skeletal, fast isoform 4 [Homo sapiens]
Length = 250
Score = 325 bits (833), Expect = 2e-89
Identities = 166/254 (65%), Positives = 203/254 (79%), Gaps = 7/254 (2%)
Query: 1 MSDTEEQEYEEEQPEEEAAEEEEEEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRM 60
MSD E ++ EE+ EEE A+EEEE +E KP P L PKIPEGE+VDFDDI +KR
Sbjct: 1 MSDEEVEQVEEQYEEEEEAQEEEEVQEEEKPR----PKLTAPKIPEGEKVDFDDIQKKRQ 56
Query: 61 EKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAKLAEE 120
KDL+ELQ LID HFE RKKEEEELVALKERIE+RR+ERAEQQR R EKERERQ +LAEE
Sbjct: 57 NKDLMELQALIDSHFEARKKEEEELVALKERIEKRRAERAEQQRIRAEKERERQNRLAEE 116
Query: 121 KMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERKK 180
K R+EEE+AK+RAEDD KKKK LS+MGA++ YL KA+QKRGK+QT REMK +IL+ER+K
Sbjct: 117 KARREEEDAKRRAEDDLKKKKALSSMGANYSSYLAKADQKRGKKQTAREMKKKILAERRK 176
Query: 181 PLDIDYMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYNRISHAQKFRKG 240
PL+ID++GE++LR+KA+EL + +HQLE +KF+ KLK+QKY+I L +RI AQK K
Sbjct: 177 PLNIDHLGEDKLRDKAKELWETLHQLEIDKFEFGEKLKRQKYDITTLRSRIDQAQKHSKK 236
Query: 241 AG---KGRVGGRWK 251
AG KG+VGGRWK
Sbjct: 237 AGTPAKGKVGGRWK 250
>gi|5803203 troponin T3, skeletal, fast isoform 1 [Homo sapiens]
Length = 258
Score = 321 bits (822), Expect = 4e-88
Identities = 167/264 (63%), Positives = 205/264 (77%), Gaps = 19/264 (7%)
Query: 1 MSDTEEQEYEEEQPEEEAAEEEEE----------EEERPKPSRPVVPPLIPPKIPEGERV 50
MSD E ++ EE+ EEE A+EEEE EEE+P+P L PKIPEGE+V
Sbjct: 1 MSDEEVEQVEEQYEEEEEAQEEEEVQEDTAEEDAEEEKPRPK------LTAPKIPEGEKV 54
Query: 51 DFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKE 110
DFDDI +KR KDL+ELQ LID HFE RKKEEEELVALKERIE+RR+ERAEQQR R EKE
Sbjct: 55 DFDDIQKKRQNKDLMELQALIDSHFEARKKEEEELVALKERIEKRRAERAEQQRIRAEKE 114
Query: 111 RERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREM 170
RERQ +LAEEK R+EEE+AK+RAEDD KKKK LS+MGA++ YL KA+QKRGK+QT REM
Sbjct: 115 RERQNRLAEEKARREEEDAKRRAEDDLKKKKALSSMGANYSSYLAKADQKRGKKQTAREM 174
Query: 171 KVRILSERKKPLDIDYMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYNR 230
K +IL+ER+KPL+ID++GE++LR+KA+EL + +HQLE +KF+ KLK+QKY+I L +R
Sbjct: 175 KKKILAERRKPLNIDHLGEDKLRDKAKELWETLHQLEIDKFEFGEKLKRQKYDITTLRSR 234
Query: 231 ISHAQKFRKGAG---KGRVGGRWK 251
I AQK K AG KG+VGGRWK
Sbjct: 235 IDQAQKHSKKAGTPAKGKVGGRWK 258
>gi|112789538 troponin T3, skeletal, fast isoform 2 [Homo sapiens]
Length = 256
Score = 320 bits (820), Expect = 7e-88
Identities = 165/256 (64%), Positives = 202/256 (78%), Gaps = 5/256 (1%)
Query: 1 MSDTEEQEYEEEQPEEEAAEEEEEE--EERPKPSRPVVPPLIPPKIPEGERVDFDDIHRK 58
MSD E ++ EE+ EEE A+EE E EE +P P L PKIPEGE+VDFDDI +K
Sbjct: 1 MSDEEVEQVEEQYEEEEEAQEEAAEVHEEVHEPEEKPRPKLTAPKIPEGEKVDFDDIQKK 60
Query: 59 RMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAKLA 118
R KDL+ELQ LID HFE RKKEEEELVALKERIE+RR+ERAEQQR R EKERERQ +LA
Sbjct: 61 RQNKDLMELQALIDSHFEARKKEEEELVALKERIEKRRAERAEQQRIRAEKERERQNRLA 120
Query: 119 EEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSER 178
EEK R+EEE+AK+RAEDD KKKK LS+MGA++ YL KA+QKRGK+QT REMK +IL+ER
Sbjct: 121 EEKARREEEDAKRRAEDDLKKKKALSSMGANYSSYLAKADQKRGKKQTAREMKKKILAER 180
Query: 179 KKPLDIDYMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYNRISHAQKFR 238
+KPL+ID++GE++LR+KA+EL + +HQLE +KF+ KLK+QKY+I L +RI AQK
Sbjct: 181 RKPLNIDHLGEDKLRDKAKELWETLHQLEIDKFEFGEKLKRQKYDITTLRSRIDQAQKHS 240
Query: 239 KGAG---KGRVGGRWK 251
K AG KG+VGGRWK
Sbjct: 241 KKAGTPAKGKVGGRWK 256
>gi|48255881 troponin T type 2, cardiac isoform 3 [Homo sapiens]
Length = 285
Score = 318 bits (816), Expect = 2e-87
Identities = 165/252 (65%), Positives = 201/252 (79%), Gaps = 4/252 (1%)
Query: 2 SDTEEQEYEEEQPEEEAAEEEEE--EEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKR 59
++TEE EE++ EEEA E E+ EE +PKP R +P L+PPKIP+GERVDFDDIHRKR
Sbjct: 36 AETEETRAEEDEEEEEAKEAEDGPMEESKPKP-RSFMPNLVPPKIPDGERVDFDDIHRKR 94
Query: 60 MEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAKLAE 119
MEKDL ELQ LI+ HFE RKKEEEELV+LK+RIERRR+ERAEQQR R E+E+ERQ +LAE
Sbjct: 95 MEKDLNELQALIEAHFENRKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAE 154
Query: 120 EKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERK 179
E+ R+EEEE +++AED+A+KKK LSNM HFGGY+ K E+K GKRQT RE K +IL+ER+
Sbjct: 155 ERARREEEENRRKAEDEARKKKALSNM-MHFGGYIQKTERKSGKRQTEREKKKKILAERR 213
Query: 180 KPLDIDYMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYNRISHAQKFRK 239
K L ID++ E+QLREKA+EL I+ LE+EKFDL K KQQKYEINVL NRI+ QK K
Sbjct: 214 KVLAIDHLNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSK 273
Query: 240 GAGKGRVGGRWK 251
GK +V GRWK
Sbjct: 274 TRGKAKVTGRWK 285
>gi|48255877 troponin T type 2, cardiac isoform 1 [Homo sapiens]
Length = 295
Score = 318 bits (816), Expect = 2e-87
Identities = 165/252 (65%), Positives = 201/252 (79%), Gaps = 4/252 (1%)
Query: 2 SDTEEQEYEEEQPEEEAAEEEEE--EEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKR 59
++TEE EE++ EEEA E E+ EE +PKP R +P L+PPKIP+GERVDFDDIHRKR
Sbjct: 46 AETEETRAEEDEEEEEAKEAEDGPMEESKPKP-RSFMPNLVPPKIPDGERVDFDDIHRKR 104
Query: 60 MEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAKLAE 119
MEKDL ELQ LI+ HFE RKKEEEELV+LK+RIERRR+ERAEQQR R E+E+ERQ +LAE
Sbjct: 105 MEKDLNELQALIEAHFENRKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAE 164
Query: 120 EKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERK 179
E+ R+EEEE +++AED+A+KKK LSNM HFGGY+ K E+K GKRQT RE K +IL+ER+
Sbjct: 165 ERARREEEENRRKAEDEARKKKALSNM-MHFGGYIQKTERKSGKRQTEREKKKKILAERR 223
Query: 180 KPLDIDYMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYNRISHAQKFRK 239
K L ID++ E+QLREKA+EL I+ LE+EKFDL K KQQKYEINVL NRI+ QK K
Sbjct: 224 KVLAIDHLNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSK 283
Query: 240 GAGKGRVGGRWK 251
GK +V GRWK
Sbjct: 284 TRGKAKVTGRWK 295
Score = 35.4 bits (80), Expect = 0.047
Identities = 30/139 (21%), Positives = 64/139 (46%), Gaps = 7/139 (5%)
Query: 76 EQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAKLAEEKMRKEEEEAKKRAED 135
E+ ++EE+E A++E + R E +++ + E E + + + +EEEEAK+ +
Sbjct: 9 EEYEEEEQEEAAVEEEEDWREDEDEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDG 68
Query: 136 DAKKKKVLSNMGAHFGGYLVKAEQKRGKR----QTGREMKVRILSERKKPLDIDYMGEEQ 191
++ K F LV + G+R R+ + L+E + ++ + ++
Sbjct: 69 PMEESKPKPR---SFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKK 125
Query: 192 LREKAQELSDWIHQLESEK 210
E+ L D I + +E+
Sbjct: 126 EEEELVSLKDRIERRRAER 144
>gi|112789536 troponin T3, skeletal, fast isoform 3 [Homo sapiens]
Length = 250
Score = 318 bits (815), Expect = 3e-87
Identities = 163/254 (64%), Positives = 201/254 (79%), Gaps = 7/254 (2%)
Query: 1 MSDTEEQEYEEEQPEEEAAEEEEEEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRM 60
MSD E ++ EE+ EEE A+EEEE +E KP P L PKIPEGE+VDFDDI +KR
Sbjct: 1 MSDEEVEQVEEQYEEEEEAQEEEEVQEEEKPR----PKLTAPKIPEGEKVDFDDIQKKRQ 56
Query: 61 EKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAKLAEE 120
KDL+ELQ LID HFE RKKEEEELVALKERIE+RR+ERAEQQR R EKERERQ +LAEE
Sbjct: 57 NKDLMELQALIDSHFEARKKEEEELVALKERIEKRRAERAEQQRIRAEKERERQNRLAEE 116
Query: 121 KMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERKK 180
K R+EEE+AK+RAEDD KKKK LS+MGA++ YL KA+QKRGK+QT REMK +IL+ER+K
Sbjct: 117 KARREEEDAKRRAEDDLKKKKALSSMGANYSSYLAKADQKRGKKQTAREMKKKILAERRK 176
Query: 181 PLDIDYMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYNRISHAQKFRKG 240
PL+ID++GE++LR+KA+EL + +HQLE +KF+ KLK+QKY+I + R+ KF K
Sbjct: 177 PLNIDHLGEDKLRDKAKELWETLHQLEIDKFEFGEKLKRQKYDIMNVRARVQMLAKFSKK 236
Query: 241 AG---KGRVGGRWK 251
AG KG+VGGRWK
Sbjct: 237 AGTPAKGKVGGRWK 250
>gi|48255883 troponin T type 2, cardiac isoform 4 [Homo sapiens]
Length = 282
Score = 315 bits (807), Expect = 2e-86
Identities = 166/254 (65%), Positives = 202/254 (79%), Gaps = 6/254 (2%)
Query: 2 SDTEEQEYEEEQPEEEAAEEEEE--EEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKR 59
++TEE EE++ EEEA E E+ EE +PKP R +P L+PPKIP+GERVDFDDIHRKR
Sbjct: 31 AETEETRAEEDEEEEEAKEAEDGPMEESKPKP-RSFMPNLVPPKIPDGERVDFDDIHRKR 89
Query: 60 MEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAKLAE 119
MEKDL ELQ LI+ HFE RKKEEEELV+LK+RIERRR+ERAEQQR R E+E+ERQ +LAE
Sbjct: 90 MEKDLNELQALIEAHFENRKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAE 149
Query: 120 EKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKA--EQKRGKRQTGREMKVRILSE 177
E+ R+EEEE +++AED+A+KKK LSNM HFGGY+ KA E+K GKRQT RE K +IL+E
Sbjct: 150 ERARREEEENRRKAEDEARKKKALSNM-MHFGGYIQKAQTERKSGKRQTEREKKKKILAE 208
Query: 178 RKKPLDIDYMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYNRISHAQKF 237
R+K L ID++ E+QLREKA+EL I+ LE+EKFDL K KQQKYEINVL NRI+ QK
Sbjct: 209 RRKVLAIDHLNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKV 268
Query: 238 RKGAGKGRVGGRWK 251
K GK +V GRWK
Sbjct: 269 SKTRGKAKVTGRWK 282
Score = 33.1 bits (74), Expect = 0.24
Identities = 33/131 (25%), Positives = 59/131 (45%), Gaps = 13/131 (9%)
Query: 88 LKERIERRRSERAEQQRFRTEKERERQAKLAEEKMRK-EEEEAKKRAED---DAKKKKVL 143
++E +E E E+Q E++ E +A+ E + + EEEE K AED + K K
Sbjct: 4 IEEVVEEYEEEEQEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPR 63
Query: 144 SNMGAHFGGYLVKAEQKRGKR----QTGREMKVRILSERKKPLDIDYMGEEQLREKAQEL 199
S F LV + G+R R+ + L+E + ++ + ++ E+ L
Sbjct: 64 S-----FMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSL 118
Query: 200 SDWIHQLESEK 210
D I + +E+
Sbjct: 119 KDRIERRRAER 129
>gi|48255879 troponin T type 2, cardiac isoform 2 [Homo sapiens]
Length = 288
Score = 313 bits (802), Expect = 9e-86
Identities = 165/255 (64%), Positives = 201/255 (78%), Gaps = 7/255 (2%)
Query: 2 SDTEEQEYEEEQPEEEAAEEEEE--EEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKR 59
++TEE EE++ EEEA E E+ EE +PKP R +P L+PPKIP+GERVDFDDIHRKR
Sbjct: 36 AETEETRAEEDEEEEEAKEAEDGPMEESKPKP-RSFMPNLVPPKIPDGERVDFDDIHRKR 94
Query: 60 MEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAKLAE 119
MEKDL ELQ LI+ HFE RKKEEEELV+LK+RIERRR+ERAEQQR R E+E+ERQ +LAE
Sbjct: 95 MEKDLNELQALIEAHFENRKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAE 154
Query: 120 EKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVK---AEQKRGKRQTGREMKVRILS 176
E+ R+EEEE +++AED+A+KKK LSNM HFGGY+ K E+K GKRQT RE K +IL+
Sbjct: 155 ERARREEEENRRKAEDEARKKKALSNM-MHFGGYIQKQAQTERKSGKRQTEREKKKKILA 213
Query: 177 ERKKPLDIDYMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYNRISHAQK 236
ER+K L ID++ E+QLREKA+EL I+ LE+EKFDL K KQQKYEINVL NRI+ QK
Sbjct: 214 ERRKVLAIDHLNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQK 273
Query: 237 FRKGAGKGRVGGRWK 251
K GK +V GRWK
Sbjct: 274 VSKTRGKAKVTGRWK 288
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 71.2 bits (173), Expect = 8e-13
Identities = 61/222 (27%), Positives = 99/222 (44%), Gaps = 44/222 (19%)
Query: 10 EEEQPEEEAAEEEEEEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKDLLELQT 69
++ PEE E+E+++ E+ P V F+D R+ E+ LEL+
Sbjct: 326 DQRLPEEPVLEDEQQQLEKKLP------------------VTFEDKKRENFERGNLELEK 367
Query: 70 LIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEK-ERERQAKLAEEKMRKEEEE 128
EQ++KE+E L L ER E+ R ER Q++ R + E E+Q + E R+ EEE
Sbjct: 368 RRQALLEQQRKEQERLAQL-ERAEQERKERERQEQERKRQLELEKQLEKQRELERQREEE 426
Query: 129 AKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQ------TGREMKVRILSERKKPL 182
+K E K+ L + E +R +RQ + + +L +KK L
Sbjct: 427 RRKEIERREAAKRELERQR--------QLEWERNRRQELLNQRNKEQEDIVVLKAKKKTL 478
Query: 183 DIDYMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEI 224
+ + + L+D HQLE + D+ +L Q+ EI
Sbjct: 479 EFE----------LEALNDKKHQLEGKLQDIRCRLTTQRQEI 510
Score = 46.2 bits (108), Expect = 3e-05
Identities = 30/102 (29%), Positives = 54/102 (52%), Gaps = 9/102 (8%)
Query: 54 DIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVAL---KERIERRRSERAEQ--QRFRTE 108
+IH K+ L+ Q ++ ++K++E +++ L KE +RR ER +Q + + E
Sbjct: 612 EIHNKQQ----LQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQE 667
Query: 109 KERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHF 150
E +R KL EE+ K EE KK+ ++ K++ +G F
Sbjct: 668 DEHQRPRKLHEEEKLKREESVKKKDGEEKGKQEAQDKLGRLF 709
Score = 40.8 bits (94), Expect = 0.001
Identities = 52/221 (23%), Positives = 93/221 (42%), Gaps = 52/221 (23%)
Query: 5 EEQEYEEEQPEEEAAEEEEEEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKDL 64
+E+ + E+ E+E E E +E+ER + + +EK L
Sbjct: 380 QERLAQLERAEQERKERERQEQERKR--------------------------QLELEKQL 413
Query: 65 LELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAKLAEEKMRK 124
+ + L E+R+KE E A K +ER+R + E ER R+ +L ++ ++
Sbjct: 414 EKQRELERQREEERRKEIERREAAKRELERQR---------QLEWERNRRQELLNQRNKE 464
Query: 125 EEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERK----- 179
+E+ +A KKK L K Q GK Q +++ R+ ++R+
Sbjct: 465 QEDIVVLKA-----KKKTLE---FELEALNDKKHQLEGKLQ---DIRCRLTTQRQEIEST 513
Query: 180 -KPLDIDYMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQ 219
K ++ L+++ QE + +L EK L +LKQ
Sbjct: 514 NKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQ 554
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 71.2 bits (173), Expect = 8e-13
Identities = 61/222 (27%), Positives = 99/222 (44%), Gaps = 44/222 (19%)
Query: 10 EEEQPEEEAAEEEEEEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKDLLELQT 69
++ PEE E+E+++ E+ P V F+D R+ E+ LEL+
Sbjct: 326 DQRLPEEPVLEDEQQQLEKKLP------------------VTFEDKKRENFERGNLELEK 367
Query: 70 LIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEK-ERERQAKLAEEKMRKEEEE 128
EQ++KE+E L L ER E+ R ER Q++ R + E E+Q + E R+ EEE
Sbjct: 368 RRQALLEQQRKEQERLAQL-ERAEQERKERERQEQERKRQLELEKQLEKQRELERQREEE 426
Query: 129 AKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQ------TGREMKVRILSERKKPL 182
+K E K+ L + E +R +RQ + + +L +KK L
Sbjct: 427 RRKEIERREAAKRELERQR--------QLEWERNRRQELLNQRNKEQEDIVVLKAKKKTL 478
Query: 183 DIDYMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEI 224
+ + + L+D HQLE + D+ +L Q+ EI
Sbjct: 479 EFE----------LEALNDKKHQLEGKLQDIRCRLTTQRQEI 510
Score = 46.2 bits (108), Expect = 3e-05
Identities = 30/102 (29%), Positives = 54/102 (52%), Gaps = 9/102 (8%)
Query: 54 DIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVAL---KERIERRRSERAEQ--QRFRTE 108
+IH K+ L+ Q ++ ++K++E +++ L KE +RR ER +Q + + E
Sbjct: 612 EIHNKQQ----LQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQE 667
Query: 109 KERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHF 150
E +R KL EE+ K EE KK+ ++ K++ +G F
Sbjct: 668 DEHQRPRKLHEEEKLKREESVKKKDGEEKGKQEAQDKLGRLF 709
Score = 40.8 bits (94), Expect = 0.001
Identities = 52/221 (23%), Positives = 93/221 (42%), Gaps = 52/221 (23%)
Query: 5 EEQEYEEEQPEEEAAEEEEEEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKDL 64
+E+ + E+ E+E E E +E+ER + + +EK L
Sbjct: 380 QERLAQLERAEQERKERERQEQERKR--------------------------QLELEKQL 413
Query: 65 LELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAKLAEEKMRK 124
+ + L E+R+KE E A K +ER+R + E ER R+ +L ++ ++
Sbjct: 414 EKQRELERQREEERRKEIERREAAKRELERQR---------QLEWERNRRQELLNQRNKE 464
Query: 125 EEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERK----- 179
+E+ +A KKK L K Q GK Q +++ R+ ++R+
Sbjct: 465 QEDIVVLKA-----KKKTLE---FELEALNDKKHQLEGKLQ---DIRCRLTTQRQEIEST 513
Query: 180 -KPLDIDYMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQ 219
K ++ L+++ QE + +L EK L +LKQ
Sbjct: 514 NKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQ 554
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 66.6 bits (161), Expect = 2e-11
Identities = 51/224 (22%), Positives = 110/224 (49%), Gaps = 12/224 (5%)
Query: 5 EEQEYEEEQPEEEAAEEEEEEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKDL 64
EE++ +EE+P+ + +EEEE+ R K R + + + +R+ + R++ E++
Sbjct: 256 EEEKLQEEEPQRQRELQEEEEQLR-KLERQELRRERQEEEQQQQRLRREQQLRRKQEEER 314
Query: 65 LELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAKLAEEKMRK 124
E Q + EQ+++ E++ ++++ R + ER EQQ R ++E R+ +L E+ +
Sbjct: 315 REQQ---EERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEE 371
Query: 125 EEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVR--------ILS 176
E+ +R + +++++ L + +Q R ++Q RE ++R
Sbjct: 372 RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEE 431
Query: 177 ERKKPLDIDYMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQ 220
ER + E++L+ + +E DW+ + E + + KQQ
Sbjct: 432 ERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQ 475
Score = 60.1 bits (144), Expect = 2e-09
Identities = 50/191 (26%), Positives = 97/191 (50%), Gaps = 34/191 (17%)
Query: 5 EEQEYEEEQPEEEAAEEEEEEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKDL 64
EE E E++ ++ + ++EEE R + K+ E ER R++ E+
Sbjct: 462 EETERHEQERRKQQLKRDQEEERRERWL----------KLEEEER-------REQQERRE 504
Query: 65 LELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAKLAEEKMRK 124
+L+ + EQR K +EE L++R+ R+EQQ R ++ER Q EE+ R
Sbjct: 505 QQLRREQEERREQRLKRQEEEERLQQRL------RSEQQLRREQEERREQLLKREEEKRL 558
Query: 125 EEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERKKPLDI 184
E+E ++R + + ++++ L+K E++R +++ RE + R L +R K ++
Sbjct: 559 EQERREQRLKREQEERR----------DQLLKREEERRQQRLKREQEER-LEQRLKREEV 607
Query: 185 DYMGEEQLREK 195
+ + +E+ RE+
Sbjct: 608 ERLEQEERREQ 618
Score = 59.3 bits (142), Expect = 3e-09
Identities = 55/229 (24%), Positives = 105/229 (45%), Gaps = 34/229 (14%)
Query: 5 EEQEYEEEQPEEEAAEEEEEEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKDL 64
EE+ E+++ E+ E+EE + R + ++ +++ + R+
Sbjct: 493 EEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKR 552
Query: 65 LELQTLIDVHFEQRKKEEEE-----LVALKE-----RIERRRSERAEQQRFRTEKERERQ 114
E + L EQR K E+E L+ +E R++R + ER EQ+ R E ER Q
Sbjct: 553 EEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQ 612
Query: 115 AKLAEEKMRKEEEEAKKR-----AEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGRE 169
+ E+++++EE E ++R +E+ ++++ L + +Q+R +++ RE
Sbjct: 613 EERREQRLKREEPEEERRQQLLKSEEQEERRQ----------QQLRREQQERREQRLKRE 662
Query: 170 MKVRILSERKKPLDIDYMGEEQLREKAQE---------LSDWIHQLESE 209
+ L +R K + E++L E+ QE + W QLESE
Sbjct: 663 EEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESE 711
Score = 58.9 bits (141), Expect = 4e-09
Identities = 58/254 (22%), Positives = 119/254 (46%), Gaps = 24/254 (9%)
Query: 7 QEYEEEQPEEEAAEEEEEEEERPKPSRPVVPPLIPPKIPEGE---------------RVD 51
+E +++Q E +EEEE+ R V K+ E E +++
Sbjct: 223 REEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLE 282
Query: 52 FDDIHRKRMEKD-----LLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFR 106
++ R+R E++ L Q L E+R++++EE +ER E ++ ER EQQ R
Sbjct: 283 RQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERRE-QQEERREQQLRR 341
Query: 107 TEKERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQT 166
++ER Q E++ + E++ ++ E++ +++++ L + +Q R ++Q
Sbjct: 342 EQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQL 401
Query: 167 GREMKVRILSERKKPLDIDYMGEEQL-REKAQELSDWIHQLESEKFDLMAKLKQQKYEIN 225
RE ++R E++ + E+QL RE+ +E + H+ E + L + ++++ +
Sbjct: 402 RREQQLR--REQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLK 459
Query: 226 VLYNRISHAQKFRK 239
H Q+ RK
Sbjct: 460 REEETERHEQERRK 473
Score = 54.7 bits (130), Expect = 8e-08
Identities = 51/239 (21%), Positives = 113/239 (47%), Gaps = 11/239 (4%)
Query: 3 DTEEQEYEEEQPEEEAAEEEEEEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEK 62
+ E +E +EE+ E++ E++EE + R E E + R+ E+
Sbjct: 311 EEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEE 370
Query: 63 DLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKE--RERQAKLAEE 120
+ E Q + EQ+ + E++L +E+ RR + +Q+ R E++ RE+Q + ++
Sbjct: 371 ERREQQ----LRREQQLRREQQL--RREQQLRREQQLRREQQLRREQQLRREQQLRREQQ 424
Query: 121 KMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERKK 180
R++EEE ++ + ++++ L +L + E+ Q R+ +++ E ++
Sbjct: 425 LRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEER 484
Query: 181 PLDIDYMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYNRISHAQKFRK 239
+ EE+ RE+ + + + + E+ + +LK+Q+ E L R+ Q+ R+
Sbjct: 485 RERWLKLEEEERREQQERREQQLRREQEERRE--QRLKRQEEE-ERLQQRLRSEQQLRR 540
Score = 53.9 bits (128), Expect = 1e-07
Identities = 55/200 (27%), Positives = 93/200 (46%), Gaps = 21/200 (10%)
Query: 7 QEYEEEQPEEEAAEEEEEE---EERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKD 63
QE E + EEE ++EEE+ EER K R + + E E V ++ R E +
Sbjct: 1104 QERERQCREEEELQQEEEQLLREEREKRRRQE----LERQYREEEEVQQEEEQLLREEPE 1159
Query: 64 LLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAKLAEEKMR 123
Q L E++ +EEEEL +E++ R E+ Q ERERQ + EE+++
Sbjct: 1160 KRRRQEL-----ERQYREEEELQQEEEQLLREEQEKRRQ-------ERERQYR-EEEELQ 1206
Query: 124 KEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERKKPLD 183
+++ + + R ED K K K + + R+++ L +R+ D
Sbjct: 1207 RQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQD 1266
Query: 184 IDY-MGEEQLREKAQELSDW 202
+ + +GE+Q R++ QE W
Sbjct: 1267 LQHLLGEQQERDREQERRRW 1286
Score = 52.4 bits (124), Expect = 4e-07
Identities = 48/209 (22%), Positives = 99/209 (47%), Gaps = 16/209 (7%)
Query: 3 DTEEQEYEEEQPEEEAAEEEEEEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEK 62
D E + +E++ +++ + EEE +R + + P L E + + ++ +R E+
Sbjct: 859 DQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREER 918
Query: 63 DLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEK-----------ER 111
+ Q + E+ + ++EE L+E E+RR + E+Q + +K E
Sbjct: 919 EKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEP 978
Query: 112 ERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGR-EM 170
E++ + EK +EEEE ++ E ++++ Y K E ++ + Q R E
Sbjct: 979 EKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREER 1038
Query: 171 KVRILSERKKPLDIDYMGEEQLREKAQEL 199
+ R L ER++ Y EE+L+++ ++L
Sbjct: 1039 EKRRLQERER----QYREEEELQQEEEQL 1063
Score = 50.8 bits (120), Expect = 1e-06
Identities = 59/239 (24%), Positives = 112/239 (46%), Gaps = 49/239 (20%)
Query: 5 EEQEYEEEQPEEEAAE-----EEEEEEERPKPSRPVVPPLIPPK---------------- 43
EE+ + ++Q EE+ + + EE+ ER + PPL +
Sbjct: 751 EERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRF 810
Query: 44 IPEGERVDFDDIHRKRMEKDLLELQTLIDVHFEQRKKE-EEELVALKERIERRRSE---R 99
+PE E + R+ EK+L L+ + +R ++ +EE L+E ERRRS+ R
Sbjct: 811 LPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRR 870
Query: 100 AEQQRFRTEKERERQ-----AKLA-EEKMRKE-------------EEEAKKRAEDDAKKK 140
++ R++ E+ER+R+ AK A +E++RKE EE K+R ++ ++
Sbjct: 871 DQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQY 930
Query: 141 KVLSNMGAHFGGYLVKAEQKRGKRQTGRE-MKVRILSERKKPLDIDYMGEEQLREKAQE 198
+ + L + +KR +++ R+ K + L ++++ L +GEE + + QE
Sbjct: 931 REEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQL----LGEEPEKRRRQE 985
Score = 50.8 bits (120), Expect = 1e-06
Identities = 63/264 (23%), Positives = 115/264 (43%), Gaps = 59/264 (22%)
Query: 3 DTEEQEYEEEQPEEEAAEEEEEEEERPKPSRPVVPPLIPPKI--PEGERVDFDDIHRKRM 60
D + + EEEQ +E E++ +ER + R L K+ E ER +D + R
Sbjct: 1552 DRDRKFREEEQLRQEREEQQLSRQERDRKFR-----LEEQKVRRQEQERKFMEDEQQLRR 1606
Query: 61 EKDLLELQTLIDVHF------------EQRKKEEEELVALKERIERRRSERAEQ------ 102
++ +L+ D F +Q ++E + L+E + RR ER +Q
Sbjct: 1607 QEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRD 1666
Query: 103 QRFRTE--------------KERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGA 148
++FR E +ER+R+ + E+++R++E E K E+ +++ L
Sbjct: 1667 RKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFR 1726
Query: 149 HFGGYLVKAEQKRGKRQTGREMKVRILSE------------RKKPLDIDYMGEEQLREKA 196
+ EQ++ +RQ E +IL E R++ D + EEQLR++
Sbjct: 1727 EEEQLRQETEQEQLRRQ---ERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQER 1783
Query: 197 QELSDWIHQLESEKFDLMAKLKQQ 220
+E QL S++ D + ++Q
Sbjct: 1784 EE-----QQLRSQESDRKFREEEQ 1802
Score = 50.8 bits (120), Expect = 1e-06
Identities = 58/261 (22%), Positives = 122/261 (46%), Gaps = 29/261 (11%)
Query: 3 DTEEQEYEEEQPEEEAAEEEEEEEERPKPSRPVVPPLIPPK-----IPEGERVDFDDIHR 57
D + + EEEQ +E E++ +ER + R L + + E +++ ++ R
Sbjct: 1664 DRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELER 1723
Query: 58 KRMEKDLLELQTLIDVHFEQRKK----EEEELVALKERIERRRSE-----RAEQQRFRTE 108
K E++ L +T + Q + EEE+L +E + RR E R E+Q +
Sbjct: 1724 KFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQER 1783
Query: 109 KERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGR 168
+E++ +++ ++ K R+EE+ ++R E + ++ G Y + EQ + + Q
Sbjct: 1784 EEQQLRSQESDRKFREEEQLRQEREEQQLRPQQ-------RDGKYRWEEEQLQLEEQ--- 1833
Query: 169 EMKVRILSERKKPLDIDYMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQ---KYEIN 225
E ++R +R+ + + +E+ R + QEL W + + + + KL+++ + +
Sbjct: 1834 EQRLRQERDRQYRAEEQFATQEKSRREEQEL--WQEEEQKRRQERERKLREEHIRRQQKE 1891
Query: 226 VLYNRISHAQKFRKGAGKGRV 246
+R K ++G G GR+
Sbjct: 1892 EQRHRQVGEIKSQEGKGHGRL 1912
Score = 49.7 bits (117), Expect = 2e-06
Identities = 63/264 (23%), Positives = 127/264 (48%), Gaps = 56/264 (21%)
Query: 7 QEYEEEQPEEEAAEEEEEE---EERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKD 63
QE+E + +++ ++EEE+ EER K ++ E ER ++ ++ E+
Sbjct: 1014 QEWERQYRKKDELQQEEEQLLREEREKR-----------RLQERERQYREEEELQQEEEQ 1062
Query: 64 LL--ELQTLIDVHFEQRKKEEEELVALKERI------ERRRSERA------------EQQ 103
LL E +T E++ ++EEEL +E++ +RRR ER E+Q
Sbjct: 1063 LLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQ 1122
Query: 104 RFRTEKERERQAKLA-----EEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAE 158
R E+E+ R+ +L EE++++EEE+ R E + ++++ L Y + E
Sbjct: 1123 LLREEREKRRRQELERQYREEEEVQQEEEQL-LREEPEKRRRQELERQ------YREEEE 1175
Query: 159 QKRGKRQTGREMKVRILSERKKPLDIDYMGEEQLREKAQELSDWIHQLESEKFDLMAKLK 218
++ + Q RE + + ER++ Y EE+L+ + ++ ++ E ++ DL + +
Sbjct: 1176 LQQEEEQLLREEQEKRRQERER----QYREEEELQRQKRKQR---YRDEDQRSDLKWQWE 1228
Query: 219 QQKYEI---NVLYNRISHAQKFRK 239
+K N +Y + ++FR+
Sbjct: 1229 PEKENAVRDNKVYCKGRENEQFRQ 1252
Score = 49.7 bits (117), Expect = 2e-06
Identities = 64/241 (26%), Positives = 118/241 (48%), Gaps = 24/241 (9%)
Query: 7 QEYEEEQPEEEAAE----EEEEEEERPKPSRPVVPPLIPPKIPEGERVDFDD-IHRK-RM 60
QE EE+Q + + EEE++ R + R + + PE + ++ + +HR+ R
Sbjct: 1471 QEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQ 1530
Query: 61 EKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAKLAEE 120
K L E Q L Q+++++ + +E E+ R ER EQQ R +ER+R+ +L E+
Sbjct: 1531 RKFLQEEQQLRRQERGQQRRQDRDRKFREE--EQLRQEREEQQLSR--QERDRKFRLEEQ 1586
Query: 121 KMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSE-RK 179
K+R++E+E +K ED+ + ++ G ++ E+ R R+ + ++ R + +
Sbjct: 1587 KVRRQEQE-RKFMEDEQQLRR-------QEGQQQLRQERDRKFREDEQLLQEREEQQLHR 1638
Query: 180 KPLDIDYMGEE-QLREKAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYNRISHAQKFR 238
+ D ++ EE QLR QE + KF +L Q+ E + R +KFR
Sbjct: 1639 QERDRKFLEEEPQLRR--QEREQQLRHDRDRKFREEEQLLQEGEEQQL--RRQERDRKFR 1694
Query: 239 K 239
+
Sbjct: 1695 E 1695
Score = 45.4 bits (106), Expect = 5e-05
Identities = 57/251 (22%), Positives = 105/251 (41%), Gaps = 65/251 (25%)
Query: 3 DTEEQEYEEEQPEEEAAEE----EEEEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRK 58
+ EQ + E+PEEE ++ EE+EE R + R E+ + + K
Sbjct: 614 ERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRR-------------EQQERREQRLK 660
Query: 59 RMEKDLLELQTLIDVHFEQRKKEE---EELVALKERIERR-------------------- 95
R E++ Q L H E+R+++E EE +ERI+ R
Sbjct: 661 REEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVY 720
Query: 96 -RSERAEQQRFRTEKERERQAKLAEEKMRKEEEEAKKRAED------------DAKKKKV 142
R + E QR R E+E +R+ + +E + ++EE +++ E+ + K ++
Sbjct: 721 SRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERG 780
Query: 143 LSNMGAHFGGYLVKAEQKRGKRQTGREMKV---------RILSERKKPLDIDYMGEE--- 190
+ A + Q R + + RE + R R++ ++ ++ EE
Sbjct: 781 RQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQL 840
Query: 191 QLREKAQELSD 201
Q RE+AQ+L +
Sbjct: 841 QRRERAQQLQE 851
Score = 45.4 bits (106), Expect = 5e-05
Identities = 45/217 (20%), Positives = 104/217 (47%), Gaps = 24/217 (11%)
Query: 5 EEQEYEEEQPEEEAAEEEEEEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKDL 64
EE++ E+ E+ +E E + + K + L+ + + R + + +R+ E
Sbjct: 939 EEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQ 998
Query: 65 LELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTE-KERERQAKLAEEKMR 123
E Q L + ++R++E E K+ +++ + ++R + +ERERQ + EE+++
Sbjct: 999 EEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYR-EEEELQ 1057
Query: 124 KEEE-------EAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMK----- 171
+EEE E ++R E + + +K + L + +KR +++ R+ +
Sbjct: 1058 QEEEQLLGEERETRRRQELERQYRKE-EELQQEEEQLLREEPEKRRRQERERQCREEEEL 1116
Query: 172 ----VRILSE-----RKKPLDIDYMGEEQLREKAQEL 199
++L E R++ L+ Y EE+++++ ++L
Sbjct: 1117 QQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQL 1153
Score = 43.9 bits (102), Expect = 1e-04
Identities = 58/246 (23%), Positives = 110/246 (44%), Gaps = 48/246 (19%)
Query: 3 DTEEQEYEEEQPEEEAAEEEEEEEERPKPSRPVVPPLIPPKIPEGERVDFDD-------- 54
+ + +E EE Q EEE EE+E+ R + R + +R +D
Sbjct: 1167 ERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQ 1226
Query: 55 -------------IHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAE 101
++ K E + + + L D R+ +++ L E+ ER R E
Sbjct: 1227 WEPEKENAVRDNKVYCKGRENE--QFRQLEDSQLRDRQSQQDLQHLLGEQQERDR----E 1280
Query: 102 QQRFRTEKERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKR 161
Q+R R ++R+R E+ R+E++EAK+R ++K++L + E+KR
Sbjct: 1281 QER-RRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLRE----------EREEKR 1329
Query: 162 GKRQTGREMK--VRILSER-KKPLDIDYMGEEQLREKAQELSDWIHQLESEKF-DLMAKL 217
+++T R+ + ++L ER ++PL Q R++ + HQ + KF + +L
Sbjct: 1330 RRQETDRKFREEEQLLQEREEQPL------RRQERDRKFREEELRHQEQGRKFLEEEQRL 1383
Query: 218 KQQKYE 223
++Q+ E
Sbjct: 1384 RRQERE 1389
Score = 41.6 bits (96), Expect = 7e-04
Identities = 47/226 (20%), Positives = 106/226 (46%), Gaps = 22/226 (9%)
Query: 7 QEYEEEQPEEEAAEEEEEEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKDLLE 66
Q+ + PEEE E EE++E + + + + + E +R + + R E+ LL+
Sbjct: 1287 QQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQ 1346
Query: 67 LQTLIDVHFEQRKKE--EEEL---------VALKERIERRRSERA---EQQRFRTEKERE 112
+ + ++R ++ EEEL + ++R+ R+ ER E+Q+ R ++ +
Sbjct: 1347 EREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQ 1406
Query: 113 RQAKLAEEKMRKEEEEAKKRAED-DAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMK 171
+ + + K R+EE++ ++ D ++++ +L + +Q R +R +
Sbjct: 1407 QLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREE 1466
Query: 172 VRILSER------KKPLDIDYMGEE-QLREKAQELSDWIHQLESEK 210
++L ER ++ D ++ EE QLR + ++ +L S++
Sbjct: 1467 EQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQE 1512
Score = 39.3 bits (90), Expect = 0.003
Identities = 46/235 (19%), Positives = 101/235 (42%), Gaps = 41/235 (17%)
Query: 5 EEQEYEEEQPEEEAAEEEEEEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKDL 64
+E++ +P + EEE + R K ++ EGE ++R+E+
Sbjct: 115 QEEDQRRFEPRDRQLEEEPGQRRRQKRQEQ------ERELAEGEE---QSEKQERLEQ-- 163
Query: 65 LELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAKLAEEKMRK 124
R++ +EEL ++ + R RAE+++ ++ K E + EE++R+
Sbjct: 164 -----------RDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRR 212
Query: 125 EEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERKKPLDI 184
E +R + K+++ F + E++ KR+T +L + ++ L
Sbjct: 213 RELLELRRKGREEKQQQRRERQDRVF---QEEEEKEWRKRET-------VLRKEEEKLQE 262
Query: 185 DYMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYNRISHAQKFRK 239
+ E Q + + QE + + +LE + +L++++ E R+ Q+ R+
Sbjct: 263 E---EPQRQRELQEEEEQLRKLERQ------ELRRERQEEEQQQQRLRREQQLRR 308
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 59.7 bits (143), Expect = 2e-09
Identities = 48/226 (21%), Positives = 114/226 (50%), Gaps = 17/226 (7%)
Query: 1 MSDTEEQEYEEEQPEEEAAEEEEEEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRM 60
M + EEQ E+E+ ++ E+ E+EE+ + + + E+V + ++
Sbjct: 201 MGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQ 260
Query: 61 EKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAKLAEE 120
E+ + E + EQ +++EE+++ KE+ E+ ++++ R E+E Q + EE
Sbjct: 261 EEQMREQE-------EQMREQEEQMLKQKEQTEQEEQTGEQEEQMR---EQEEQMREQEE 310
Query: 121 KMRKEEEEAKKRAEDDAKKKKVLSNMGAHF---GGYLVKAEQKRGKRQ---TGREMKVRI 174
+MR++EE+ +++ E K+++ + + K E++ G+++ +E +VR
Sbjct: 311 QMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRK 370
Query: 175 LSER-KKPLDIDYMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQ 219
E+ +K + EEQ+R++ +++ + Q+ +K + + +Q
Sbjct: 371 QEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQ 416
Score = 47.4 bits (111), Expect = 1e-05
Identities = 47/226 (20%), Positives = 104/226 (46%), Gaps = 38/226 (16%)
Query: 6 EQEYEEEQPEEEAAEEEEEEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKDLL 65
EQE + + E + E+E + E+ R EG+ V + + E +
Sbjct: 140 EQEGQVREQEGQVREQEGQVREQEGQVRE----------QEGQ-VREQEGQVREQEGQVR 188
Query: 66 ELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAKLAEEKMRKE 125
E + + Q ++EE++ +E+++++ + EQ E Q + EE+M ++
Sbjct: 189 EQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQ---------EEQMRKQEEQMGEQ 239
Query: 126 EEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERKKPLDID 185
EE+ +K+ E K+++ + + EQ R + + RE + ++L ++++ +
Sbjct: 240 EEQVQKQEEQVQKQEEQMRK----------QEEQMREQEEQMREQEEQMLKQKEQTEQEE 289
Query: 186 YMG--EEQLREKAQELSDWIHQLES------EKFDLMAKLKQQKYE 223
G EEQ+RE+ +++ + Q+ E+ + M K ++Q +E
Sbjct: 290 QTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWE 335
Score = 46.2 bits (108), Expect = 3e-05
Identities = 34/139 (24%), Positives = 69/139 (49%), Gaps = 5/139 (3%)
Query: 1 MSDTEEQEYEEEQPEEEAAEEEEEEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRM 60
M + EEQ E+E+ E E+ E+EE+ + + E++ +
Sbjct: 298 MREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQ 357
Query: 61 EKDLLELQTLIDVHFEQRKKEEEELVALKERI---ERRRSERAEQQRFRTEKERERQAKL 117
E+ + + + + EQ +K+EE++ +E++ E + E+ EQ + E+ RE++ ++
Sbjct: 358 EEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQM 417
Query: 118 AEEK--MRKEEEEAKKRAE 134
E+K MRK+EE ++ E
Sbjct: 418 GEQKEQMRKQEEHMGEQKE 436
Score = 45.1 bits (105), Expect = 6e-05
Identities = 31/153 (20%), Positives = 77/153 (50%), Gaps = 16/153 (10%)
Query: 4 TEEQEYEEEQPEEEAAEEEEEEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKD 63
T EQE + + EE+ E+EE+ E+ + R + E++ + ++
Sbjct: 291 TGEQEEQMREQEEQMREQEEQMREQEEQMRE-----------QEEQMGKQEEQMWEQKEQ 339
Query: 64 LLELQTLIDVHFEQRKKEEEELVALKERIERRRSE---RAEQQRFRTEKERERQAKLAEE 120
+ E + + EQ ++EE++ +E++ ++ + + EQ R + E+ R+++ ++ E+
Sbjct: 340 MWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQ 399
Query: 121 K--MRKEEEEAKKRAEDDAKKKKVLSNMGAHFG 151
K M +++E+ +++ E ++K+ + H G
Sbjct: 400 KEQMGEQKEQMREQEEQMGEQKEQMRKQEEHMG 432
Score = 29.3 bits (64), Expect = 3.4
Identities = 43/241 (17%), Positives = 109/241 (45%), Gaps = 11/241 (4%)
Query: 5 EEQEYEEEQPEEEAAEEEEEEEERPKPSRPVVPPLIPPKIP---EGERVDFDDIHRKRME 61
EE + + + +EE E E+ E + + L KIP EG+ V + + E
Sbjct: 7 EELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQ-VREQEGQVREQE 65
Query: 62 KDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKE---RERQAKLA 118
+ E + + Q +++E ++ + ++ + + EQ+ E+E RE++ ++
Sbjct: 66 GQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVR 125
Query: 119 EEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSER 178
E++ + E+E + R E + + ++ + G + Q R + RE + ++ +
Sbjct: 126 EQEGQVREQEGQVR-EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQE 184
Query: 179 KKPLDID-YMGEE--QLREKAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYNRISHAQ 235
+ + + MGE+ Q+ E+ +++ + Q++ ++ + + +Q + + + + Q
Sbjct: 185 GQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQ 244
Query: 236 K 236
K
Sbjct: 245 K 245
>gi|92859701 myosin VI [Homo sapiens]
Length = 1285
Score = 59.7 bits (143), Expect = 2e-09
Identities = 37/122 (30%), Positives = 67/122 (54%), Gaps = 9/122 (7%)
Query: 76 EQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAKLAEEKMRKEEEEAKKRAED 135
+Q+++E E L ++E +E+ R R E ++ R ++E ER+ KL E RK+EEE +K+ ED
Sbjct: 917 KQQEEEAERLRRIQEEMEKERKRREEDEKRRRKEEEERRMKLEMEAKRKQEEEERKKRED 976
Query: 136 DAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERKKPLDIDYMGEEQLREK 195
D K+ + A L + +++ ++Q E + R +R+ L I E + ++
Sbjct: 977 DEKR------IQAEVEAQLARQKEEESQQQAVLEQERR---DRELALRIAQSEAELISDE 1027
Query: 196 AQ 197
AQ
Sbjct: 1028 AQ 1029
Score = 47.0 bits (110), Expect = 2e-05
Identities = 45/182 (24%), Positives = 80/182 (43%), Gaps = 29/182 (15%)
Query: 62 KDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAKLAEEK 121
K + Q I ++ K EEL++ ++ +++ E +R + E E+ER+ + +EK
Sbjct: 886 KSTMMTQEQIQKEYDALVKSSEELLSALQKKKQQEEEAERLRRIQEEMEKERKRREEDEK 945
Query: 122 MR-KEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERKK 180
R KEEEE + + E +AK+K + E++R KR+ + RI +E
Sbjct: 946 RRRKEEEERRMKLEMEAKRK---------------QEEEERKKREDDEK---RIQAE--- 984
Query: 181 PLDIDYMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYNRISHAQKFRKG 240
E QL + +E S LE E+ D L+ + E ++ + R+
Sbjct: 985 -------VEAQLARQKEEESQQQAVLEQERRDRELALRIAQSEAELISDEAQADLALRRN 1037
Query: 241 AG 242
G
Sbjct: 1038 DG 1039
Score = 42.4 bits (98), Expect = 4e-04
Identities = 23/77 (29%), Positives = 46/77 (59%), Gaps = 12/77 (15%)
Query: 57 RKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAK 116
RKR E+D E+R+++EEE +K +E +R + E+++ R + E+ QA+
Sbjct: 937 RKRREED------------EKRRRKEEEERRMKLEMEAKRKQEEEERKKREDDEKRIQAE 984
Query: 117 LAEEKMRKEEEEAKKRA 133
+ + R++EEE++++A
Sbjct: 985 VEAQLARQKEEESQQQA 1001
Score = 38.1 bits (87), Expect = 0.007
Identities = 22/91 (24%), Positives = 49/91 (53%), Gaps = 2/91 (2%)
Query: 55 IHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQ 114
+ +K+ +++ E I E+ +K EE + + E R + E + R ++E ER+
Sbjct: 913 LQKKKQQEEEAERLRRIQEEMEKERKRREEDEKRRRKEEEERRMKLEMEAKRKQEEEERK 972
Query: 115 AKLAEEKMRKEEEEAK--KRAEDDAKKKKVL 143
+ +EK + E EA+ ++ E++++++ VL
Sbjct: 973 KREDDEKRIQAEVEAQLARQKEEESQQQAVL 1003
Score = 36.6 bits (83), Expect = 0.021
Identities = 35/142 (24%), Positives = 61/142 (42%), Gaps = 27/142 (19%)
Query: 5 EEQEYEEEQPEEEAAEEEEEEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKDL 64
EE E E ++ EE+ +EEEER K+ + ++ RK+ E D
Sbjct: 931 EEMEKERKRREEDEKRRRKEEEERRM------------KLEMEAKRKQEEEERKKREDDE 978
Query: 65 LELQTLIDVHFEQRKKEEEELVALKERIERR------RSERAEQQRFRTEKERE------ 112
+Q ++ ++K+EE + A+ E+ ERR R ++E + E + +
Sbjct: 979 KRIQAEVEAQLARQKEEESQQQAVLEQ-ERRDRELALRIAQSEAELISDEAQADLALRRN 1037
Query: 113 --RQAKLAEEKMRKEEEEAKKR 132
+ K+ E+M KE E R
Sbjct: 1038 DGTRPKMTPEQMAKEMSEFLSR 1059
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 59.7 bits (143), Expect = 2e-09
Identities = 56/204 (27%), Positives = 104/204 (50%), Gaps = 27/204 (13%)
Query: 3 DTEEQEYEEEQPEEEAAEEEEEEEERPKPSRPVVPPLIPPKIPEGE---RVDFDDIHRKR 59
+ +E EYE EEE E E+E E PS V P GE R DF + ++
Sbjct: 315 EKDETEYEYSGSEEEEEEVPEQEGE---PSSIVNVP--------GESTLRRDFLRLQQEN 363
Query: 60 MEK-DLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAKLA 118
E+ + L Q L+ + R++EE + L ER +R ++ +++R ++ RER+A+
Sbjct: 364 KERSEALRRQQLLQEQ-QLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQ 422
Query: 119 EEK-MRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSE 177
+E+ R+ E+E K+R E+ +++K +AE+++ + + +E R L E
Sbjct: 423 QEREQRRREQEEKRRLEELERRRKEEEERR--------RAEEEKRRVEREQEYIRRQLEE 474
Query: 178 RKKPLDIDYMGEEQLREKAQELSD 201
++ L++ + ++ L+E+A L D
Sbjct: 475 EQRHLEV--LQQQLLQEQAMLLHD 496
Score = 32.7 bits (73), Expect = 0.31
Identities = 43/221 (19%), Positives = 86/221 (38%), Gaps = 65/221 (29%)
Query: 68 QTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTE------------------- 108
Q L + E + + LK+ I+R R +R E+ E
Sbjct: 282 QLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPS 341
Query: 109 ----------------------KER----ERQAKLAEEKMRKEEE-------EAKKRAED 135
KER RQ L E+++R++EE E +KR E
Sbjct: 342 SIVNVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQ 401
Query: 136 DAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERKKPLDID-YMGEEQLRE 194
++++ L + ++ +RQ RE + R E+++ +++ EE+ R
Sbjct: 402 QKEQRRRLEEQ---------QRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERR 452
Query: 195 KAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYNRISHAQ 235
+A+E ++E E+ + +L++++ + VL ++ Q
Sbjct: 453 RAEEEK---RRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQ 490
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 59.7 bits (143), Expect = 2e-09
Identities = 56/204 (27%), Positives = 104/204 (50%), Gaps = 27/204 (13%)
Query: 3 DTEEQEYEEEQPEEEAAEEEEEEEERPKPSRPVVPPLIPPKIPEGE---RVDFDDIHRKR 59
+ +E EYE EEE E E+E E PS V P GE R DF + ++
Sbjct: 315 EKDETEYEYSGSEEEEEEVPEQEGE---PSSIVNVP--------GESTLRRDFLRLQQEN 363
Query: 60 MEK-DLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAKLA 118
E+ + L Q L+ + R++EE + L ER +R ++ +++R ++ RER+A+
Sbjct: 364 KERSEALRRQQLLQEQ-QLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQ 422
Query: 119 EEK-MRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSE 177
+E+ R+ E+E K+R E+ +++K +AE+++ + + +E R L E
Sbjct: 423 QEREQRRREQEEKRRLEELERRRKEEEERR--------RAEEEKRRVEREQEYIRRQLEE 474
Query: 178 RKKPLDIDYMGEEQLREKAQELSD 201
++ L++ + ++ L+E+A L D
Sbjct: 475 EQRHLEV--LQQQLLQEQAMLLHD 496
Score = 32.7 bits (73), Expect = 0.31
Identities = 43/221 (19%), Positives = 86/221 (38%), Gaps = 65/221 (29%)
Query: 68 QTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTE------------------- 108
Q L + E + + LK+ I+R R +R E+ E
Sbjct: 282 QLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPS 341
Query: 109 ----------------------KER----ERQAKLAEEKMRKEEE-------EAKKRAED 135
KER RQ L E+++R++EE E +KR E
Sbjct: 342 SIVNVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQ 401
Query: 136 DAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERKKPLDID-YMGEEQLRE 194
++++ L + ++ +RQ RE + R E+++ +++ EE+ R
Sbjct: 402 QKEQRRRLEEQ---------QRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERR 452
Query: 195 KAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYNRISHAQ 235
+A+E ++E E+ + +L++++ + VL ++ Q
Sbjct: 453 RAEEEK---RRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQ 490
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 59.3 bits (142), Expect = 3e-09
Identities = 59/225 (26%), Positives = 112/225 (49%), Gaps = 28/225 (12%)
Query: 3 DTEEQEYEEEQPEEEAAEEEEEEEERPKPSRPVVPPLIPPKIPEGE---RVDFDDIHRKR 59
+ +E EYE EEE E E+E E PS V P GE R DF + ++
Sbjct: 315 EKDETEYEYSGSEEEEEEVPEQEGE---PSSIVNVP--------GESTLRRDFLRLQQEN 363
Query: 60 MEK-DLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAKLA 118
E+ + L Q L+ + R++EE + L ER +R ++ +++R ++ RER+A+
Sbjct: 364 KERSEALRRQQLLQEQ-QLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQ 422
Query: 119 EEK-MRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSE 177
+E+ R+ E+E K+R E+ +++K +AE+++ + + +E R L E
Sbjct: 423 QEREQRRREQEEKRRLEELERRRKEEEERR--------RAEEEKRRVEREQEYIRRQLEE 474
Query: 178 RKKPLDIDYMGEEQLREKAQELS-DWIHQLESEKFDLMAKLKQQK 221
++ L++ + ++ L+E+A L W E + + + + QQ+
Sbjct: 475 EQRHLEV--LQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQE 517
Score = 55.5 bits (132), Expect = 4e-08
Identities = 66/245 (26%), Positives = 117/245 (47%), Gaps = 63/245 (25%)
Query: 4 TEEQEYEEEQPEEEAAEEEEEEEERPK----PSRPVVPPLIPPKIPEGE---RVDFDDIH 56
T ++ E+++ E E + EEEEEE P+ PS V P GE R DF +
Sbjct: 309 TRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVP--------GESTLRRDFLRLQ 360
Query: 57 RKRMEK-DLLELQTLIDVHFEQRKKEEEE-----LVALKERIE--------------RRR 96
++ E+ + L Q L+ EQ+ +E+EE L ++RIE R R
Sbjct: 361 QENKERSEALRRQQLLQ---EQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRRER 417
Query: 97 SERAEQQRFRTEKERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVK 156
R +Q+R + +E+E + +L E + R++EEE ++RAE++ ++ V+
Sbjct: 418 EARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRR---------------VE 462
Query: 157 AEQKRGKRQTGRE------MKVRILSERKKPLDIDYMGEEQLREKAQELSDWIHQLESEK 210
EQ+ +RQ E ++ ++L E+ L+ + E+ R+ A+ L QL+ E+
Sbjct: 463 REQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLECRWREMEEHRQ-AERLQ---RQLQQEQ 518
Query: 211 FDLMA 215
L++
Sbjct: 519 AYLLS 523
Score = 32.7 bits (73), Expect = 0.31
Identities = 43/221 (19%), Positives = 86/221 (38%), Gaps = 65/221 (29%)
Query: 68 QTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTE------------------- 108
Q L + E + + LK+ I+R R +R E+ E
Sbjct: 282 QLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPS 341
Query: 109 ----------------------KER----ERQAKLAEEKMRKEEE-------EAKKRAED 135
KER RQ L E+++R++EE E +KR E
Sbjct: 342 SIVNVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQ 401
Query: 136 DAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERKKPLDID-YMGEEQLRE 194
++++ L + ++ +RQ RE + R E+++ +++ EE+ R
Sbjct: 402 QKEQRRRLEEQ---------QRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERR 452
Query: 195 KAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYNRISHAQ 235
+A+E ++E E+ + +L++++ + VL ++ Q
Sbjct: 453 RAEEEK---RRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQ 490
>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
Length = 245
Score = 58.9 bits (141), Expect = 4e-09
Identities = 55/180 (30%), Positives = 85/180 (47%), Gaps = 34/180 (18%)
Query: 5 EEQEYEEEQPEEEAAEEEEEEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKDL 64
EE+E ++ + E+E E EE+E+ + K + E R + R+R E+
Sbjct: 93 EERERKKRRREKENKEGEEKEKRKKKEKK------------ERGRTSKEGKERERKEERK 140
Query: 65 LELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKER-ERQAKLAEEKMR 123
E + + E+R+KE E KER +R R + E++ R EKER ER+ + K R
Sbjct: 141 REERKERERKKEEREKERER----KERKKRERKQVGEKEEERKEKERKERKKRERNRKER 196
Query: 124 KEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGK---RQTGREMKVRILSERKK 180
K+E E K+R E ++KK K E+K+ + RQT K R ERK+
Sbjct: 197 KKERERKERRERKKERKK--------------KEERKKERQKDRQTNWREKERGKRERKE 242
Score = 55.1 bits (131), Expect = 6e-08
Identities = 49/193 (25%), Positives = 85/193 (44%), Gaps = 33/193 (17%)
Query: 6 EQEYEEEQPEEEAAEEEEEEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKDLL 65
E E +E +E +E ++E ER K R ER R + EK
Sbjct: 44 EIETRKEGKKERESERKKERREREKRKR--------------EREKERKRERGKKEKK-- 87
Query: 66 ELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAKLAEEKMRKE 125
+RKKEE E + E + E E+++ + +KER R +K +E+ RKE
Sbjct: 88 ----------GERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKE 137
Query: 126 EEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERKKPLDID 185
E + ++R E + KK++ K +KR ++Q G + + R ERK+ +
Sbjct: 138 ERKREERKERERKKEEREKERER-------KERKKRERKQVGEKEEERKEKERKERKKRE 190
Query: 186 YMGEEQLREKAQE 198
+E+ +E+ ++
Sbjct: 191 RNRKERKKERERK 203
Score = 50.1 bits (118), Expect = 2e-06
Identities = 49/190 (25%), Positives = 89/190 (46%), Gaps = 17/190 (8%)
Query: 61 EKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSER-----AEQQRFRTEKERERQA 115
+ ++ E + I+ E +K+ E E KER ER + +R +++R + EK+ ER+
Sbjct: 35 QSEIREREREIETRKEGKKERESE--RKKERREREKRKREREKERKRERGKKEKKGERKK 92
Query: 116 KLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRIL 175
+ E K R+ E+E K+ E + +KKK G E K +R+ R+ + R
Sbjct: 93 EERERKKRRREKENKEGEEKEKRKKKEKKERGR------TSKEGKERERKEERKREERKE 146
Query: 176 SERKKPLDIDYMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYNRISHAQ 235
ERKK + E + +E+ + + + E E+ + K +++K E N + +
Sbjct: 147 RERKKE---EREKERERKERKKRERKQVGEKEEERKEKERK-ERKKRERNRKERKKERER 202
Query: 236 KFRKGAGKGR 245
K R+ K R
Sbjct: 203 KERRERKKER 212
Score = 49.3 bits (116), Expect = 3e-06
Identities = 35/130 (26%), Positives = 67/130 (51%), Gaps = 22/130 (16%)
Query: 3 DTEEQEYEEEQPEEEAAEEEEEEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEK 62
+ + +E +E + ++E E+E E +ER K R V E ER + + RK+ E+
Sbjct: 138 ERKREERKERERKKEEREKERERKERKKRERKQVGE------KEEERKEKERKERKKRER 191
Query: 63 DLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAKLAEEKM 122
+ ++RKKE E KER ER++ + +++R + E++++RQ E++
Sbjct: 192 NR-----------KERKKERER----KERRERKKERKKKEER-KKERQKDRQTNWREKER 235
Query: 123 RKEEEEAKKR 132
K E + +K+
Sbjct: 236 GKRERKERKK 245
Score = 47.8 bits (112), Expect = 9e-06
Identities = 37/133 (27%), Positives = 60/133 (45%), Gaps = 15/133 (11%)
Query: 7 QEYEEEQPEEEAAEEEEEEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKDLLE 66
+E +E + +EE EE +E ER K R K E ++V + RK E+
Sbjct: 128 KEGKERERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKER---- 183
Query: 67 LQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAKLAEEKMRKEE 126
++RKK E K+ ER R ER E+++ R +KE ++ + + + E
Sbjct: 184 ---------KERKKRERNRKERKK--ERERKERRERKKERKKKEERKKERQKDRQTNWRE 232
Query: 127 EEAKKRAEDDAKK 139
+E KR + KK
Sbjct: 233 KERGKRERKERKK 245
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 58.2 bits (139), Expect = 7e-09
Identities = 56/209 (26%), Positives = 98/209 (46%), Gaps = 35/209 (16%)
Query: 18 AAEEEEEEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKDLLELQTLIDVHFEQ 77
++EE ++EEER + S +I E+++ +D R E+ LE + + EQ
Sbjct: 234 SSEEPKQEEEREQGS---------DEISHHEKMEEEDKERAEAERARLEAEERERIKAEQ 284
Query: 78 RKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAKLAEEKMRKEEEEAKKRAEDDA 137
KK +E ++ + ER ++ E+ RE + + AEE+ R +EEE KRA ++
Sbjct: 285 DKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEE--KRAAEER 342
Query: 138 KKKKVLSNMGAHFGGYLVKAEQKRG--KRQTGREMKVRILSERKKPLDIDYMGEEQLREK 195
++ +K E+KR +RQ +E + R ER++ EE+ + K
Sbjct: 343 QR---------------IKEEEKRAAEERQRIKEEEKRAAEERQRA-----RAEEEEKAK 382
Query: 196 AQELSDWIHQLESEKFDLM-AKLKQQKYE 223
+E QLE +K + K+K +K E
Sbjct: 383 VEE-QKRNKQLEEKKHAMQETKIKGEKVE 410
Score = 55.8 bits (133), Expect = 3e-08
Identities = 60/258 (23%), Positives = 114/258 (44%), Gaps = 36/258 (13%)
Query: 10 EEEQPEEEAAEEEEEEEERPKPSRPVVPPLIPPKIPEGE-RVDFDDIHRKRMEKDLLELQ 68
+ E+ ++E E+EEEEEE+PK I E + V ++ + E+ ++
Sbjct: 179 DAEENKKEDKEKEEEEEEKPKRG----------SIGENQVEVMVEEKTTESQEETVVMSL 228
Query: 69 TLIDVHFEQRKKEEE-----ELVALKERIERRRSERAEQQRFRTEKER------ERQAKL 117
+ E+ K+EEE + ++ E++E ERAE +R R E E E+ K+
Sbjct: 229 KNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKI 288
Query: 118 AEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRG--KRQTGREMKVRIL 175
A+E+ R E EE E + ++ + M + E+KR +RQ +E + R
Sbjct: 289 ADERARIEAEEKAAAQERERREAEERERM---------REEEKRAAEERQRIKEEEKRAA 339
Query: 176 SERKKPLDIDYMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYNRISHAQ 235
ER++ + + E+ + +E + + + + K K ++ + N HA
Sbjct: 340 EERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAM 399
Query: 236 KFRKGAG---KGRVGGRW 250
+ K G + ++ G+W
Sbjct: 400 QETKIKGEKVEQKIEGKW 417
Score = 55.8 bits (133), Expect = 3e-08
Identities = 54/228 (23%), Positives = 105/228 (46%), Gaps = 29/228 (12%)
Query: 2 SDTEEQEYEEEQPEEEAAEEEEEEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRME 61
S+ +QE E EQ +E + E+ EEE + ER + + + E
Sbjct: 235 SEEPKQEEEREQGSDEISHHEKMEEE------------------DKERAEAERARLEAEE 276
Query: 62 KDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAKLAEEK 121
++ ++ + + E+ + E EE A +ER ERR +E E+ R ++ E + ++ EE+
Sbjct: 277 RERIKAEQDKKIADERARIEAEEKAAAQER-ERREAEERERMREEEKRAAEERQRIKEEE 335
Query: 122 MRKEEE-----EAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILS 176
R EE E +KRA ++ ++ K A E+++ K + + K L
Sbjct: 336 KRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQ--LE 393
Query: 177 ERKKPLDIDYMGEEQLREKAQELSDWIHQLESEKFDLM-AKLKQQKYE 223
E+K + + E++ +K + W+++ ++++ L A LK+Q E
Sbjct: 394 EKKHAMQETKIKGEKVEQKIE--GKWVNEKKAQEDKLQTAVLKKQGEE 439
Score = 50.4 bits (119), Expect = 1e-06
Identities = 32/104 (30%), Positives = 62/104 (59%), Gaps = 12/104 (11%)
Query: 42 PKIPEGERVDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEE---ELVALKERIERRRSE 98
P++ G+R++ ++ R+R E + E + L ++K++E EL LK++ E RR
Sbjct: 528 PQVEAGKRLE--ELRRRRGETESEEFEKL-------KQKQQEAALELEELKKKREERRKV 578
Query: 99 RAEQQRFRTEKERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKV 142
E+++ R ++E +R+ + EEK R +EE ++RAE K++K+
Sbjct: 579 LEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKM 622
Score = 42.0 bits (97), Expect = 5e-04
Identities = 39/137 (28%), Positives = 67/137 (48%), Gaps = 7/137 (5%)
Query: 13 QPEEEAAEEEEEEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKDLLELQTLID 72
+P A+ + +E E P+ + + E E +F+ + +K+ E LEL+ L
Sbjct: 512 RPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEA-ALELEELKK 570
Query: 73 VHFEQRKK-EEEELVALKERIERRRSERAEQQRFRTEKERERQAKLAEEKMRKEEEEAKK 131
E+RK EEEE +E +R+ E E++R + E ER R+A+ AE++ + E+
Sbjct: 571 KREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIER-RRAEAAEKRQKMPED---- 625
Query: 132 RAEDDAKKKKVLSNMGA 148
DD K K + G+
Sbjct: 626 GLSDDKKPFKCFTPKGS 642
Score = 41.6 bits (96), Expect = 7e-04
Identities = 32/103 (31%), Positives = 55/103 (53%), Gaps = 28/103 (27%)
Query: 3 DTEEQEYEE-EQPEEEAAEEEEEEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRME 61
+TE +E+E+ +Q ++EAA E EE +++ + R V ++ ++ RK+ E
Sbjct: 545 ETESEEFEKLKQKQQEAALELEELKKKREERRKV--------------LEEEEQRRKQEE 590
Query: 62 KDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQR 104
D ++ +EEEE LKE IERRR+E AE+++
Sbjct: 591 AD-------------RKLREEEEKRRLKEEIERRRAEAAEKRQ 620
Score = 38.5 bits (88), Expect = 0.006
Identities = 60/249 (24%), Positives = 107/249 (42%), Gaps = 31/249 (12%)
Query: 1 MSDTEEQEYEEEQ----PEEEAAEEEE---EEEERPKPSRPVVPPLIPPKIPEGERVDFD 53
M + E++ EE Q E+ AAEE + EEE+R R + E +R +
Sbjct: 317 MREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAE 376
Query: 54 DIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRT------ 107
+ + ++E+ Q H Q K + E V K + ++A++ + +T
Sbjct: 377 EEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQ 436
Query: 108 -----EKERERQAKLAEEK--MRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQK 160
K + ++ KL E+K +KEE + +K +D K++V S M G VK++
Sbjct: 437 GEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQ-- 494
Query: 161 RGKRQTGR-EMKVRILSERKKPLDIDYMGEE-----QLREKAQELSDWIHQLESEKFDLM 214
G+ T + + S +D E + ++ +EL + ESE+F+
Sbjct: 495 NGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFE-- 552
Query: 215 AKLKQQKYE 223
KLKQ++ E
Sbjct: 553 -KLKQKQQE 560
Score = 38.1 bits (87), Expect = 0.007
Identities = 35/160 (21%), Positives = 76/160 (47%), Gaps = 17/160 (10%)
Query: 76 EQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAKLAEEKMRKEEEEAKKRAED 135
E R+++ EE+ ERI +R++ E++ R + R RQ +L + K+EEE+ + D
Sbjct: 9 ELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQ----KQEEESLGQVTD 64
Query: 136 -----------DAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERKKPLDI 184
D + K +N G ++ +R+ R+ +++ ER+K D
Sbjct: 65 QVEVNAQNSVPDEEAKTTTTNTQVE-GDDEAAFLERLARREERRQKRLQEALERQKEFD- 122
Query: 185 DYMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEI 224
+ + L ++ + + + E+ + + ++ +Q++YEI
Sbjct: 123 PTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEI 162
Score = 38.1 bits (87), Expect = 0.007
Identities = 53/255 (20%), Positives = 108/255 (42%), Gaps = 37/255 (14%)
Query: 5 EEQEYEEEQPEEEAAEEEE----EEEERPKPSRPVVPPLIPPKIPEGERVDFDD----IH 56
EE++ E+ + AEEEE EE++R K + KI +GE+V+ ++
Sbjct: 361 EEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKI-KGEKVEQKIEGKWVN 419
Query: 57 RKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAK 116
K+ ++D L+ L E+ K + + L+E + E + ++ + +KE + + K
Sbjct: 420 EKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVK 479
Query: 117 LAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGY-------------------LVKA 157
++ + E + E K K N + GG L +
Sbjct: 480 SFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEEL 539
Query: 158 EQKRGK---------RQTGREMKVRILSERKKPLDIDYMGEEQLREKAQELSDWIHQLES 208
++RG+ +Q +E + + +KK + + EE+ + + QE +D + E
Sbjct: 540 RRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEE 599
Query: 209 EKFDLMAKLKQQKYE 223
EK L ++++++ E
Sbjct: 600 EKRRLKEEIERRRAE 614
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 57.8 bits (138), Expect = 9e-09
Identities = 52/220 (23%), Positives = 108/220 (49%), Gaps = 21/220 (9%)
Query: 7 QEYEEEQPEEEAAEEEEEEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKDLLE 66
+E EE+ E+E E+EE+ + + KI E E+ + R E+ + E
Sbjct: 347 RELEEKMHEQEKIREQEEKRQEEE------------KIREQEKRQEQEAKMWRQEEKIRE 394
Query: 67 LQTLIDVHFEQRKKEEEELVALKERI---ERRRSERAEQQRFRTEKERERQAKL--AEEK 121
+ I E +++EE++ +E++ E E+ E+ R + EK RE++ K+ EEK
Sbjct: 395 QEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEK 454
Query: 122 MRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERKKP 181
+R++EE +++ E +++ + A + E+ R + + RE + +I + +K
Sbjct: 455 IREQEEMMQEQEEKMGEQEGKMCEQEAKM---QEQEEKMRRQEEKIREQEKKIREQEEKI 511
Query: 182 LDIDYMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQK 221
+ + M +EQ EK E + + + E + + K+++Q+
Sbjct: 512 REQEEMMQEQ-EEKMWEQEEKMCEQEEKMQEQEEKMRRQE 550
Score = 57.4 bits (137), Expect = 1e-08
Identities = 50/235 (21%), Positives = 120/235 (51%), Gaps = 22/235 (9%)
Query: 5 EEQEYEEEQPEEEAAEEEEEEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKDL 64
EE+ + +E+ +E E+ +E+EE+ + K+ E + ++ + R ++++
Sbjct: 287 EEKMWRQEEKIQEREEKIQEQEEKIREQE--------EKMRRQEEMMWEKEEKMRRQEEM 338
Query: 65 LELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFR-TEKERERQAKL--AEEK 121
+ + E++ +E EE + +E+I + +R E+++ R EK +E++AK+ EEK
Sbjct: 339 MWEK-------EEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEK 391
Query: 122 MRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERKKP 181
+R++EE+ +++ E ++++ MG + E+ + + + R + +I + KK
Sbjct: 392 IREQEEKIREQEEMMQEQEE---KMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKI 448
Query: 182 LDIDYMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYNRISHAQK 236
+ + EQ E QE + + + E + + AK+++Q+ ++ +I +K
Sbjct: 449 REQEEKIREQ-EEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEK 502
Score = 44.7 bits (104), Expect = 8e-05
Identities = 46/186 (24%), Positives = 87/186 (46%), Gaps = 31/186 (16%)
Query: 1 MSDTEEQEYEEEQPEEEAAEEEEEEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRM 60
M + EE+ E+E+ E EE +E+EE+ + KI E E+ + + R
Sbjct: 406 MQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEE--------KIREQEKKIREQEEKIRE 457
Query: 61 EKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQ----RFRTEKERERQAK 116
++++++ Q E + E+E + +E RR+ E+ +Q R + EK RE++
Sbjct: 458 QEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEM 517
Query: 117 LAE--EKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRI 174
+ E EKM ++EE K E + K ++ + E+ R + + RE +VR+
Sbjct: 518 MQEQEEKMWEQEE---KMCEQEEKMQE--------------QEEKMRRQEEKMREQEVRL 560
Query: 175 LSERKK 180
+ +K
Sbjct: 561 RQQEEK 566
Score = 37.0 bits (84), Expect = 0.016
Identities = 45/200 (22%), Positives = 99/200 (49%), Gaps = 31/200 (15%)
Query: 49 RVDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVA-LKERIER-----RRSERAEQ 102
+++ ++ RK LL Q + + KE + + A L+ ++E R +++ E+
Sbjct: 229 QLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEE 288
Query: 103 QRFRTEKE-RERQAKL---------AEEKMRKEEE-----EAKKRAEDD---AKKKKVLS 144
+ +R E++ +ER+ K+ EEKMR++EE E K R +++ K++K+
Sbjct: 289 KMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRE 348
Query: 145 -NMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERKKPLDIDYMGEEQLREKAQELSDWI 203
H + + E+KR + + RE + R E K + EE++RE+ +++ +
Sbjct: 349 LEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKM-----WRQEEKIREQEEKIREQ- 402
Query: 204 HQLESEKFDLMAKLKQQKYE 223
++ E+ + M + +++ +E
Sbjct: 403 EEMMQEQEEKMGEQEEKMWE 422
Score = 31.6 bits (70), Expect = 0.68
Identities = 29/148 (19%), Positives = 69/148 (46%), Gaps = 8/148 (5%)
Query: 81 EEEELVALKERIERRRSERAEQQRFRTEKERERQAKLAEEKMRKEEEEAKKRAEDDAKKK 140
E+E+ + + + RR A+ Q R ++ + ++A + A K+ E +A+
Sbjct: 96 EDEQKASHQHQEALRRELEAQVQTIRILTCQKTELQMA----LYYSQHAVKQLEGEARDL 151
Query: 141 KVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERKKPLDIDY----MGEEQLREKA 196
+ F G L +A ++ + + L++ + L ++ + +E+L+EK
Sbjct: 152 ISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKN 211
Query: 197 QELSDWIHQLESEKFDLMAKLKQQKYEI 224
+L + + +ESEK ++ +K+ K ++
Sbjct: 212 AKLQEKLQLVESEKSEIQLNVKELKRKL 239
>gi|56549694 enabled homolog isoform a [Homo sapiens]
Length = 591
Score = 57.0 bits (136), Expect = 2e-08
Identities = 39/148 (26%), Positives = 81/148 (54%), Gaps = 20/148 (13%)
Query: 5 EEQEYEEEQPEEEAAEEEEEEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKDL 64
EE E + Q +E+ ++E E E + E ER++ + + R+R+E++
Sbjct: 138 EELEIQRRQLQEQQRQKELERERLERERM------------ERERLERERLERERLERER 185
Query: 65 LELQTLIDVHFEQRKKEEEELVALKERIERR----RSERAEQQRFRTEKERERQAKLAEE 120
LE + L E++++E +E + +ER+ER+ R ER +++R + +ERER +L E
Sbjct: 186 LEQEQL---ERERQERERQERLERQERLERQERLERQERLDRER-QERQERERLERLERE 241
Query: 121 KMRKEEEEAKKRAEDDAKKKKVLSNMGA 148
+ +E +E +R + + ++++ +S+ A
Sbjct: 242 RQERERQEQLEREQLEWERERRISSAAA 269
Score = 55.5 bits (132), Expect = 4e-08
Identities = 42/145 (28%), Positives = 69/145 (47%), Gaps = 21/145 (14%)
Query: 6 EQEYEEEQPEEEAAEEEEEEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKDLL 65
++E E E+ E E E E E ER + R E ER++ + + R+R E++
Sbjct: 153 QKELERERLERERMERERLERERLERERL-----------ERERLEQEQLERERQERERQ 201
Query: 66 ELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRF----RTEKERERQAKLAEEK 121
E Q + E +E + +ER++R R ER E++R R +ERERQ +L E+
Sbjct: 202 ERLE------RQERLERQERLERQERLDRERQERQERERLERLERERQERERQEQLEREQ 255
Query: 122 MRKEEEEAKKRAEDDAKKKKVLSNM 146
+ E E A A + L+++
Sbjct: 256 LEWERERRISSAAAPASVETPLNSV 280
Score = 49.7 bits (117), Expect = 2e-06
Identities = 38/172 (22%), Positives = 81/172 (47%), Gaps = 31/172 (18%)
Query: 31 PSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKE 90
P+ P +P ++ G + +I R+++++ +QR+KE E +E
Sbjct: 118 PTLPRQNSQLPAQVQNGPSQEELEIQRRQLQE-------------QQRQKELE-----RE 159
Query: 91 RIERRRSERAEQQRFRTEKERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHF 150
R+ER R ER +R R E+ER + +L +E++ +E +E +++ + +++
Sbjct: 160 RLERERMERERLERERLERERLERERLEQEQLERERQERERQERLERQER---------- 209
Query: 151 GGYLVKAEQKRGKRQTGREMKVRILSERKKPLDIDYMGEEQLREKAQELSDW 202
L + E+ + + RE + R ER + L+ + E+ + +E +W
Sbjct: 210 ---LERQERLERQERLDRERQERQERERLERLERERQERERQEQLEREQLEW 258
>gi|39930375 enabled homolog isoform b [Homo sapiens]
Length = 570
Score = 57.0 bits (136), Expect = 2e-08
Identities = 39/148 (26%), Positives = 81/148 (54%), Gaps = 20/148 (13%)
Query: 5 EEQEYEEEQPEEEAAEEEEEEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKDL 64
EE E + Q +E+ ++E E E + E ER++ + + R+R+E++
Sbjct: 138 EELEIQRRQLQEQQRQKELERERLERERM------------ERERLERERLERERLERER 185
Query: 65 LELQTLIDVHFEQRKKEEEELVALKERIERR----RSERAEQQRFRTEKERERQAKLAEE 120
LE + L E++++E +E + +ER+ER+ R ER +++R + +ERER +L E
Sbjct: 186 LEQEQL---ERERQERERQERLERQERLERQERLERQERLDRER-QERQERERLERLERE 241
Query: 121 KMRKEEEEAKKRAEDDAKKKKVLSNMGA 148
+ +E +E +R + + ++++ +S+ A
Sbjct: 242 RQERERQEQLEREQLEWERERRISSAAA 269
Score = 55.5 bits (132), Expect = 4e-08
Identities = 42/145 (28%), Positives = 69/145 (47%), Gaps = 21/145 (14%)
Query: 6 EQEYEEEQPEEEAAEEEEEEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKDLL 65
++E E E+ E E E E E ER + R E ER++ + + R+R E++
Sbjct: 153 QKELERERLERERMERERLERERLERERL-----------ERERLEQEQLERERQERERQ 201
Query: 66 ELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRF----RTEKERERQAKLAEEK 121
E Q + E +E + +ER++R R ER E++R R +ERERQ +L E+
Sbjct: 202 ERLE------RQERLERQERLERQERLDRERQERQERERLERLERERQERERQEQLEREQ 255
Query: 122 MRKEEEEAKKRAEDDAKKKKVLSNM 146
+ E E A A + L+++
Sbjct: 256 LEWERERRISSAAAPASVETPLNSV 280
Score = 49.7 bits (117), Expect = 2e-06
Identities = 38/172 (22%), Positives = 81/172 (47%), Gaps = 31/172 (18%)
Query: 31 PSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKE 90
P+ P +P ++ G + +I R+++++ +QR+KE E +E
Sbjct: 118 PTLPRQNSQLPAQVQNGPSQEELEIQRRQLQE-------------QQRQKELE-----RE 159
Query: 91 RIERRRSERAEQQRFRTEKERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHF 150
R+ER R ER +R R E+ER + +L +E++ +E +E +++ + +++
Sbjct: 160 RLERERMERERLERERLERERLERERLEQEQLERERQERERQERLERQER---------- 209
Query: 151 GGYLVKAEQKRGKRQTGREMKVRILSERKKPLDIDYMGEEQLREKAQELSDW 202
L + E+ + + RE + R ER + L+ + E+ + +E +W
Sbjct: 210 ---LERQERLERQERLDRERQERQERERLERLERERQERERQEQLEREQLEW 258
>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo
sapiens]
Length = 1293
Score = 56.6 bits (135), Expect = 2e-08
Identities = 41/150 (27%), Positives = 73/150 (48%), Gaps = 14/150 (9%)
Query: 8 EYEEEQPEEEAAEEEEEEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKDLL-- 65
E E + E A EEEE + + + R L + E +R + +++ R++ E+ L
Sbjct: 732 EQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQ 791
Query: 66 ---ELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKER---------ER 113
E+ E+R+++EE L L+ER R +++ R ++E E
Sbjct: 792 REQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEA 851
Query: 114 QAKLAEEKMRKEEEEAKKRAEDDAKKKKVL 143
Q +L E ++R EEE A+ R E++ +K+K L
Sbjct: 852 QRRLEENRLRMEEEAARLRHEEEERKRKEL 881
Score = 55.8 bits (133), Expect = 3e-08
Identities = 39/173 (22%), Positives = 82/173 (47%), Gaps = 12/173 (6%)
Query: 67 LQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAKLAEEKMRKEE 126
L+ L + + K E+E + R +R ER Q+ R ++E + + EE+ R+EE
Sbjct: 717 LEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREE 776
Query: 127 EEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERKKPLDIDY 186
EE +R +++A +++ + Q+ + + +E +R L ER++ +
Sbjct: 777 EELARRKQEEALRRQREQEIALR--------RQREEEERQQQEEALRRLEERRREEEERR 828
Query: 187 MGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYNRISHAQKFRK 239
EE LR++ +E + W + E + +L++ + + R+ H ++ RK
Sbjct: 829 KQEELLRKQEEEAAKWAREEE----EAQRRLEENRLRMEEEAARLRHEEEERK 877
Score = 45.4 bits (106), Expect = 5e-05
Identities = 45/182 (24%), Positives = 79/182 (43%), Gaps = 26/182 (14%)
Query: 5 EEQEYEEEQPEEEAAEEEEEEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKDL 64
+++E Q EEE EEEE R K + +R ++ R++ E+ L
Sbjct: 758 QQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQR---EEEERQQQEEAL 814
Query: 65 LELQTLIDVHFEQRKKEE-----EELVALKERIERRRSERAEQQRFRTEKERERQAKLAE 119
L+ E+RK+EE EE A R E R E+ R R E+E R
Sbjct: 815 RRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAAR------ 868
Query: 120 EKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERK 179
+R EEEE K++ + ++K+++ + +Q+ R+ ++ + + L++ K
Sbjct: 869 --LRHEEEERKRKELEVQRQKELMRQ----------RQQQQEALRRLQQQQQQQQLAQMK 916
Query: 180 KP 181
P
Sbjct: 917 LP 918
Score = 38.1 bits (87), Expect = 0.007
Identities = 49/233 (21%), Positives = 106/233 (45%), Gaps = 46/233 (19%)
Query: 3 DTEEQEYEEEQPEEEAAEEEEEEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEK 62
+ +E EE + +EE ++EEE K +R E E + +R RME+
Sbjct: 818 EERRREEEERRKQEELLR--KQEEEAAKWAR-----------EEEEAQRRLEENRLRMEE 864
Query: 63 DLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAKLAEEKM 122
+ L+ H E+ +K +E V ++ + R+R + +Q+ R +++++Q +LA+ K+
Sbjct: 865 EAARLR-----HEEEERKRKELEVQRQKELMRQRQQ--QQEALRRLQQQQQQQQLAQMKL 917
Query: 123 RKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERKKPL 182
++ + + LS + K E++R +RQ E +R++
Sbjct: 918 PSSSTWGQQSNTTACQSQATLSL------AEIQKLEEER-ERQLREE-------QRRQQR 963
Query: 183 DIDYMGEEQLREKAQELSDW------------IHQLESEKFDLMAKLKQQKYE 223
++ ++Q +++ Q+LS W + +++ E+ M K +QQ+ +
Sbjct: 964 ELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQ 1016
>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo
sapiens]
Length = 1320
Score = 56.6 bits (135), Expect = 2e-08
Identities = 41/150 (27%), Positives = 73/150 (48%), Gaps = 14/150 (9%)
Query: 8 EYEEEQPEEEAAEEEEEEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKDLL-- 65
E E + E A EEEE + + + R L + E +R + +++ R++ E+ L
Sbjct: 759 EQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQ 818
Query: 66 ---ELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKER---------ER 113
E+ E+R+++EE L L+ER R +++ R ++E E
Sbjct: 819 REQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEA 878
Query: 114 QAKLAEEKMRKEEEEAKKRAEDDAKKKKVL 143
Q +L E ++R EEE A+ R E++ +K+K L
Sbjct: 879 QRRLEENRLRMEEEAARLRHEEEERKRKEL 908
Score = 55.8 bits (133), Expect = 3e-08
Identities = 39/173 (22%), Positives = 82/173 (47%), Gaps = 12/173 (6%)
Query: 67 LQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAKLAEEKMRKEE 126
L+ L + + K E+E + R +R ER Q+ R ++E + + EE+ R+EE
Sbjct: 744 LEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREE 803
Query: 127 EEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERKKPLDIDY 186
EE +R +++A +++ + Q+ + + +E +R L ER++ +
Sbjct: 804 EELARRKQEEALRRQREQEIALR--------RQREEEERQQQEEALRRLEERRREEEERR 855
Query: 187 MGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYNRISHAQKFRK 239
EE LR++ +E + W + E + +L++ + + R+ H ++ RK
Sbjct: 856 KQEELLRKQEEEAAKWAREEE----EAQRRLEENRLRMEEEAARLRHEEEERK 904
Score = 45.4 bits (106), Expect = 5e-05
Identities = 45/182 (24%), Positives = 79/182 (43%), Gaps = 26/182 (14%)
Query: 5 EEQEYEEEQPEEEAAEEEEEEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKDL 64
+++E Q EEE EEEE R K + +R ++ R++ E+ L
Sbjct: 785 QQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQR---EEEERQQQEEAL 841
Query: 65 LELQTLIDVHFEQRKKEE-----EELVALKERIERRRSERAEQQRFRTEKERERQAKLAE 119
L+ E+RK+EE EE A R E R E+ R R E+E R
Sbjct: 842 RRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAAR------ 895
Query: 120 EKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERK 179
+R EEEE K++ + ++K+++ + +Q+ R+ ++ + + L++ K
Sbjct: 896 --LRHEEEERKRKELEVQRQKELMRQ----------RQQQQEALRRLQQQQQQQQLAQMK 943
Query: 180 KP 181
P
Sbjct: 944 LP 945
Score = 38.1 bits (87), Expect = 0.007
Identities = 49/233 (21%), Positives = 106/233 (45%), Gaps = 46/233 (19%)
Query: 3 DTEEQEYEEEQPEEEAAEEEEEEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEK 62
+ +E EE + +EE ++EEE K +R E E + +R RME+
Sbjct: 845 EERRREEEERRKQEELLR--KQEEEAAKWAR-----------EEEEAQRRLEENRLRMEE 891
Query: 63 DLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAKLAEEKM 122
+ L+ H E+ +K +E V ++ + R+R + +Q+ R +++++Q +LA+ K+
Sbjct: 892 EAARLR-----HEEEERKRKELEVQRQKELMRQRQQ--QQEALRRLQQQQQQQQLAQMKL 944
Query: 123 RKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERKKPL 182
++ + + LS + K E++R +RQ E +R++
Sbjct: 945 PSSSTWGQQSNTTACQSQATLSL------AEIQKLEEER-ERQLREE-------QRRQQR 990
Query: 183 DIDYMGEEQLREKAQELSDW------------IHQLESEKFDLMAKLKQQKYE 223
++ ++Q +++ Q+LS W + +++ E+ M K +QQ+ +
Sbjct: 991 ELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQ 1043
>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 56.6 bits (135), Expect = 2e-08
Identities = 41/150 (27%), Positives = 73/150 (48%), Gaps = 14/150 (9%)
Query: 8 EYEEEQPEEEAAEEEEEEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKDLL-- 65
E E + E A EEEE + + + R L + E +R + +++ R++ E+ L
Sbjct: 738 EQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQ 797
Query: 66 ---ELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKER---------ER 113
E+ E+R+++EE L L+ER R +++ R ++E E
Sbjct: 798 REQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEA 857
Query: 114 QAKLAEEKMRKEEEEAKKRAEDDAKKKKVL 143
Q +L E ++R EEE A+ R E++ +K+K L
Sbjct: 858 QRRLEENRLRMEEEAARLRHEEEERKRKEL 887
Score = 55.8 bits (133), Expect = 3e-08
Identities = 39/173 (22%), Positives = 82/173 (47%), Gaps = 12/173 (6%)
Query: 67 LQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAKLAEEKMRKEE 126
L+ L + + K E+E + R +R ER Q+ R ++E + + EE+ R+EE
Sbjct: 723 LEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREE 782
Query: 127 EEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERKKPLDIDY 186
EE +R +++A +++ + Q+ + + +E +R L ER++ +
Sbjct: 783 EELARRKQEEALRRQREQEIALR--------RQREEEERQQQEEALRRLEERRREEEERR 834
Query: 187 MGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYNRISHAQKFRK 239
EE LR++ +E + W + E + +L++ + + R+ H ++ RK
Sbjct: 835 KQEELLRKQEEEAAKWAREEE----EAQRRLEENRLRMEEEAARLRHEEEERK 883
Score = 45.4 bits (106), Expect = 5e-05
Identities = 45/182 (24%), Positives = 79/182 (43%), Gaps = 26/182 (14%)
Query: 5 EEQEYEEEQPEEEAAEEEEEEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKDL 64
+++E Q EEE EEEE R K + +R ++ R++ E+ L
Sbjct: 764 QQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQR---EEEERQQQEEAL 820
Query: 65 LELQTLIDVHFEQRKKEE-----EELVALKERIERRRSERAEQQRFRTEKERERQAKLAE 119
L+ E+RK+EE EE A R E R E+ R R E+E R
Sbjct: 821 RRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAAR------ 874
Query: 120 EKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERK 179
+R EEEE K++ + ++K+++ + +Q+ R+ ++ + + L++ K
Sbjct: 875 --LRHEEEERKRKELEVQRQKELMRQ----------RQQQQEALRRLQQQQQQQQLAQMK 922
Query: 180 KP 181
P
Sbjct: 923 LP 924
Score = 38.1 bits (87), Expect = 0.007
Identities = 49/233 (21%), Positives = 106/233 (45%), Gaps = 46/233 (19%)
Query: 3 DTEEQEYEEEQPEEEAAEEEEEEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEK 62
+ +E EE + +EE ++EEE K +R E E + +R RME+
Sbjct: 824 EERRREEEERRKQEELLR--KQEEEAAKWAR-----------EEEEAQRRLEENRLRMEE 870
Query: 63 DLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAKLAEEKM 122
+ L+ H E+ +K +E V ++ + R+R + +Q+ R +++++Q +LA+ K+
Sbjct: 871 EAARLR-----HEEEERKRKELEVQRQKELMRQRQQ--QQEALRRLQQQQQQQQLAQMKL 923
Query: 123 RKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERKKPL 182
++ + + LS + K E++R +RQ E +R++
Sbjct: 924 PSSSTWGQQSNTTACQSQATLSL------AEIQKLEEER-ERQLREE-------QRRQQR 969
Query: 183 DIDYMGEEQLREKAQELSDW------------IHQLESEKFDLMAKLKQQKYE 223
++ ++Q +++ Q+LS W + +++ E+ M K +QQ+ +
Sbjct: 970 ELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQ 1022
>gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 56.6 bits (135), Expect = 2e-08
Identities = 41/150 (27%), Positives = 73/150 (48%), Gaps = 14/150 (9%)
Query: 8 EYEEEQPEEEAAEEEEEEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKDLL-- 65
E E + E A EEEE + + + R L + E +R + +++ R++ E+ L
Sbjct: 738 EQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQ 797
Query: 66 ---ELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKER---------ER 113
E+ E+R+++EE L L+ER R +++ R ++E E
Sbjct: 798 REQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEA 857
Query: 114 QAKLAEEKMRKEEEEAKKRAEDDAKKKKVL 143
Q +L E ++R EEE A+ R E++ +K+K L
Sbjct: 858 QRRLEENRLRMEEEAARLRHEEEERKRKEL 887
Score = 55.8 bits (133), Expect = 3e-08
Identities = 39/173 (22%), Positives = 82/173 (47%), Gaps = 12/173 (6%)
Query: 67 LQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAKLAEEKMRKEE 126
L+ L + + K E+E + R +R ER Q+ R ++E + + EE+ R+EE
Sbjct: 723 LEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREE 782
Query: 127 EEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERKKPLDIDY 186
EE +R +++A +++ + Q+ + + +E +R L ER++ +
Sbjct: 783 EELARRKQEEALRRQREQEIALR--------RQREEEERQQQEEALRRLEERRREEEERR 834
Query: 187 MGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYNRISHAQKFRK 239
EE LR++ +E + W + E + +L++ + + R+ H ++ RK
Sbjct: 835 KQEELLRKQEEEAAKWAREEE----EAQRRLEENRLRMEEEAARLRHEEEERK 883
Score = 45.4 bits (106), Expect = 5e-05
Identities = 45/182 (24%), Positives = 79/182 (43%), Gaps = 26/182 (14%)
Query: 5 EEQEYEEEQPEEEAAEEEEEEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKDL 64
+++E Q EEE EEEE R K + +R ++ R++ E+ L
Sbjct: 764 QQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQR---EEEERQQQEEAL 820
Query: 65 LELQTLIDVHFEQRKKEE-----EELVALKERIERRRSERAEQQRFRTEKERERQAKLAE 119
L+ E+RK+EE EE A R E R E+ R R E+E R
Sbjct: 821 RRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAAR------ 874
Query: 120 EKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERK 179
+R EEEE K++ + ++K+++ + +Q+ R+ ++ + + L++ K
Sbjct: 875 --LRHEEEERKRKELEVQRQKELMRQ----------RQQQQEALRRLQQQQQQQQLAQMK 922
Query: 180 KP 181
P
Sbjct: 923 LP 924
Score = 38.1 bits (87), Expect = 0.007
Identities = 49/233 (21%), Positives = 106/233 (45%), Gaps = 46/233 (19%)
Query: 3 DTEEQEYEEEQPEEEAAEEEEEEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEK 62
+ +E EE + +EE ++EEE K +R E E + +R RME+
Sbjct: 824 EERRREEEERRKQEELLR--KQEEEAAKWAR-----------EEEEAQRRLEENRLRMEE 870
Query: 63 DLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAKLAEEKM 122
+ L+ H E+ +K +E V ++ + R+R + +Q+ R +++++Q +LA+ K+
Sbjct: 871 EAARLR-----HEEEERKRKELEVQRQKELMRQRQQ--QQEALRRLQQQQQQQQLAQMKL 923
Query: 123 RKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERKKPL 182
++ + + LS + K E++R +RQ E +R++
Sbjct: 924 PSSSTWGQQSNTTACQSQATLSL------AEIQKLEEER-ERQLREE-------QRRQQR 969
Query: 183 DIDYMGEEQLREKAQELSDW------------IHQLESEKFDLMAKLKQQKYE 223
++ ++Q +++ Q+LS W + +++ E+ M K +QQ+ +
Sbjct: 970 ELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQ 1022
>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
Length = 843
Score = 56.2 bits (134), Expect = 3e-08
Identities = 44/146 (30%), Positives = 72/146 (49%), Gaps = 15/146 (10%)
Query: 2 SDTEEQEYEEEQPEEEAAEEEEEEEERPKPSRPVVP-PLIPPKIPEGERVDFDDIHRKRM 60
S+ E + + +E++E+ R P P++P PLI + D + I +
Sbjct: 220 SELNAPSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKE-------DINAIEMEED 272
Query: 61 EKDLL--ELQTLIDVHF----EQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQ 114
++DL+ E+ D H E+ KKE+E KER ER R E++R E+ERER+
Sbjct: 273 KRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRERERERERE 332
Query: 115 AKLAEEKMRKEEEEAKKRAEDDAKKK 140
+ +EK R+ E E + R D K++
Sbjct: 333 REREKEKERERERE-RDRDRDRTKER 357
Score = 52.4 bits (124), Expect = 4e-07
Identities = 37/123 (30%), Positives = 62/123 (50%), Gaps = 5/123 (4%)
Query: 15 EEEAAEEEEEEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKDLLELQTLIDVH 74
E+EA EEE E K ++ + L + + +R D ++K L + + ++
Sbjct: 476 EKEAEREEERRREMAKEAKRLKEFL---EDYDDDRDDPKYYRGSALQKRLRDREKEMEAD 532
Query: 75 FEQRKKEEEELVALKERI--ERRRSERAEQQRFRTEKERERQAKLAEEKMRKEEEEAKKR 132
RK+E+EEL +++R+ E AE QR E ER RQ ++ +E +EEEE K+
Sbjct: 533 ERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQE 592
Query: 133 AED 135
E+
Sbjct: 593 KEE 595
Score = 45.4 bits (106), Expect = 5e-05
Identities = 56/228 (24%), Positives = 90/228 (39%), Gaps = 35/228 (15%)
Query: 3 DTEEQEYEEEQPEEEAAEEEEEEEERPKPSRPVVPPLIPPKIPEGERV-DFDDIHRKRME 61
+ E QE E+E+ E E E E E + R K E ER D D K +
Sbjct: 299 EKERQEIEKERRERERERERERERREREREREREREREKEKERERERERDRDRDRTKERD 358
Query: 62 KDL-----------LELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKE 110
+D D + K + E +ER R ER ++ E+E
Sbjct: 359 RDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERERERERE 418
Query: 111 RERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREM 170
RER+ + ++K R EE+ E+DA +++ L K +K Q +
Sbjct: 419 REREREREKDKKRDREED-----EEDAYERRKLER----------KLREKEAAYQ--ERL 461
Query: 171 KVRILSERKKPLDIDYMG---EEQLREKAQE---LSDWIHQLESEKFD 212
K + ERKK + + EE+ RE A+E L +++ + ++ D
Sbjct: 462 KNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDD 509
Score = 43.9 bits (102), Expect = 1e-04
Identities = 38/136 (27%), Positives = 65/136 (47%), Gaps = 11/136 (8%)
Query: 5 EEQEYEEEQPEEEAAEE-------EEEEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHR 57
+E E EEE+ E A E E+ +++R P L + ++ D+ R
Sbjct: 477 KEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDR 536
Query: 58 KRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAK- 116
KR +++L E++ + E + EL +++ ERRR + +Q+ E+E E+Q K
Sbjct: 537 KREKEELEEIRQRLLA--EGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKE 594
Query: 117 -LAEEKMRKEEEEAKK 131
EE M +EEE +K
Sbjct: 595 EKREEPMEEEEEPEQK 610
Score = 37.4 bits (85), Expect = 0.012
Identities = 37/196 (18%), Positives = 87/196 (44%), Gaps = 6/196 (3%)
Query: 3 DTEEQEYEEEQPEEEAAEEEEEEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEK 62
+ E + E + E++ + EE+EE R + L + ER+ +I ++ +
Sbjct: 414 EREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTR 473
Query: 63 DLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAKLAEEKM 122
E + + E+R++ +E LKE +E +R + + +R ++R +E
Sbjct: 474 ---EYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEME 530
Query: 123 RKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERKKPL 182
E + +++ E + ++++L+ L + EQ+ +R R+ +++ E ++
Sbjct: 531 ADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERR---RQPQIKQEPESEEEE 587
Query: 183 DIDYMGEEQLREKAQE 198
+ EE+ E +E
Sbjct: 588 EEKQEKEEKREEPMEE 603
Score = 34.7 bits (78), Expect = 0.081
Identities = 17/37 (45%), Positives = 24/37 (64%), Gaps = 1/37 (2%)
Query: 6 EQEYEEEQPEEEAAEEEEEEEERPKPSRPVVPPLIPP 42
E+E EE+Q +EE EE EEEE P+ +P + P + P
Sbjct: 584 EEEEEEKQEKEEKREEPMEEEEEPE-QKPCLKPTLRP 619
Score = 32.0 bits (71), Expect = 0.52
Identities = 14/38 (36%), Positives = 24/38 (63%)
Query: 2 SDTEEQEYEEEQPEEEAAEEEEEEEERPKPSRPVVPPL 39
S+ EE+E +E++ + E EEEEE E+ +P + P+
Sbjct: 583 SEEEEEEKQEKEEKREEPMEEEEEPEQKPCLKPTLRPI 620
>gi|4503509 eukaryotic translation initiation factor 3, subunit 10
theta, 150/170kDa [Homo sapiens]
Length = 1382
Score = 56.2 bits (134), Expect = 3e-08
Identities = 44/161 (27%), Positives = 80/161 (49%), Gaps = 18/161 (11%)
Query: 68 QTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAKLAEEKMRKEEE 127
Q + + + +KE + ++A ++ IE R+ ER E + EKE Q + +K+RK EE
Sbjct: 551 QLAVTAYLKNSRKEHQRILARRQTIEERK-ERLESLNIQREKEELEQREAELQKVRKAEE 609
Query: 128 EAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSER---KKPLDI 184
E ++ + +K+++L E ++ K++T RE +I K DI
Sbjct: 610 ERLRQEAKEREKERILQ-------------EHEQIKKKTVRERLEQIKKTELGAKAFKDI 656
Query: 185 DYMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEIN 225
D E+L + ++ + QLE EK +L +LK Q+ +I+
Sbjct: 657 DIEDLEEL-DPDFIMAKQVEQLEKEKKELQERLKNQEKKID 696
Score = 46.2 bits (108), Expect = 3e-05
Identities = 57/204 (27%), Positives = 96/204 (47%), Gaps = 36/204 (17%)
Query: 9 YEEEQPEEEAAEEEEEEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKDL---- 64
YEE++ ++ E++EEE R L K E H+ RM + L
Sbjct: 714 YEEQRIKDMDLWEQQEEE------RITTMQLEREKALE---------HKNRMSRMLEDRD 758
Query: 65 ---LELQTLIDVHFEQRKKEEEELVALKE--RIERRRSERAEQQR--FRTEKERERQAKL 117
+ L+ +E++ K+ EE +A + R+E R+ +R E++R + EKE E Q +
Sbjct: 759 LFVMRLKAARQSVYEEKLKQFEERLAEERHNRLEERKRQRKEERRITYYREKEEEEQRR- 817
Query: 118 AEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSE 177
AEE+M KE EE ++RAE AK+++ L L + E+K+ +R+ E + R E
Sbjct: 818 AEEQMLKEREE-RERAE-RAKREEELREYQERV-KKLEEVERKKRQRELEIEERERRREE 874
Query: 178 RKKPLDIDYMGEEQLREKAQELSD 201
++ +G+ L K D
Sbjct: 875 ERR------LGDSSLSRKDSRWGD 892
Score = 43.1 bits (100), Expect = 2e-04
Identities = 35/136 (25%), Positives = 66/136 (48%), Gaps = 2/136 (1%)
Query: 7 QEYEEEQPEEEAAEEEEEEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKDLLE 66
++ EEE+ E E+ E + + SR + + + R + K+ E+ L E
Sbjct: 726 EQQEEERITTMQLEREKALEHKNRMSRMLEDRDLFVMRLKAARQSVYEEKLKQFEERLAE 785
Query: 67 LQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAKL-AEEKMRKE 125
+ ++++KEE + +E+ E RAE+Q + +ERER + EE++R+
Sbjct: 786 ERHNRLEERKRQRKEERRITYYREK-EEEEQRRAEEQMLKEREERERAERAKREEELREY 844
Query: 126 EEEAKKRAEDDAKKKK 141
+E KK E + KK++
Sbjct: 845 QERVKKLEEVERKKRQ 860
Score = 37.7 bits (86), Expect = 0.010
Identities = 36/153 (23%), Positives = 68/153 (44%), Gaps = 26/153 (16%)
Query: 6 EQEYEEEQPEEEAAEEEEEEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKDLL 65
E+E EE++ EE +E EE ER + ++ E E ++ + +K E +
Sbjct: 809 EKEEEEQRRAEEQMLKEREERERAERAK-----------REEELREYQERVKKLEEVERK 857
Query: 66 ELQTLIDVHFEQRKKEEEELV--ALKERIERRRSER-------------AEQQRFRTEKE 110
+ Q +++ +R++EEE + + R + R +R +E +R EKE
Sbjct: 858 KRQRELEIEERERRREEERRLGDSSLSRKDSRWGDRDSEGTWRKGPEADSEWRRGPPEKE 917
Query: 111 RERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVL 143
R E++ + +EE +R DD ++ L
Sbjct: 918 WRRGEGRDEDRSHRRDEERPRRLGDDEDREPSL 950
Score = 28.9 bits (63), Expect = 4.4
Identities = 31/132 (23%), Positives = 57/132 (43%), Gaps = 6/132 (4%)
Query: 76 EQRKKEEEELVALKE-RIERRRSERAEQQRFRTEKERERQAKLAEEKMRKE----EEEAK 130
E+ K EE +E R R E++R R ++RE K E + +E E+
Sbjct: 1180 EKEKAREESWGPPRESRPSEEREWDREKERDRDNQDREENDKDPERERDRERDVDREDRF 1239
Query: 131 KRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERKKPLDIDYMGEE 190
+R D+ ++ + + + + ++ R R+ R+ + R L ER+ D
Sbjct: 1240 RRPRDEGGWRRGPAEESSSWRDSSRRDDRDRDDRRRERDDR-RDLRERRDLRDDRDRRGP 1298
Query: 191 QLREKAQELSDW 202
LR + +E+S W
Sbjct: 1299 PLRSEREEVSSW 1310
Score = 28.1 bits (61), Expect = 7.6
Identities = 31/150 (20%), Positives = 60/150 (40%), Gaps = 20/150 (13%)
Query: 3 DTEEQEYEEEQPEEEAAEEEEEEEE----RPKPS---RPVVPPLIPPKIPEGERVDFDDI 55
D +++E ++ PE E E + + E RP+ R R D D
Sbjct: 1212 DNQDREENDKDPERERDRERDVDREDRFRRPRDEGGWRRGPAEESSSWRDSSRRDDRDRD 1271
Query: 56 HRKRMEKDLLELQTLIDVHFEQRKK-----EEEELVALKERIERRRSERAEQQRFRTEKE 110
R+R D +L+ D+ ++ ++ E E V+ R + R+ +R E E
Sbjct: 1272 DRRRERDDRRDLRERRDLRDDRDRRGPPLRSEREEVSSWRRADDRKDDRVE--------E 1323
Query: 111 RERQAKLAEEKMRKEEEEAKKRAEDDAKKK 140
R+ ++ + ++ E + R + K+K
Sbjct: 1324 RDPPRRVPPPALSRDRERDRDREREGEKEK 1353
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.129 0.349
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,652,386
Number of Sequences: 37866
Number of extensions: 615091
Number of successful extensions: 33706
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 980
Number of HSP's successfully gapped in prelim test: 1000
Number of HSP's that attempted gapping in prelim test: 8756
Number of HSP's gapped (non-prelim): 11837
length of query: 251
length of database: 18,247,518
effective HSP length: 100
effective length of query: 151
effective length of database: 14,460,918
effective search space: 2183598618
effective search space used: 2183598618
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.