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Search of human proteins with 113205087
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|113205087 DENN/MADD domain containing 1C [Homo sapiens]
(801 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|113205087 DENN/MADD domain containing 1C [Homo sapiens] 1616 0.0
gi|218563726 DENN/MADD domain containing 1B isoform 1 [Homo sapi... 483 e-136
gi|55749779 DENN/MADD domain containing 1A isoform 1 [Homo sapiens] 473 e-133
gi|55749789 DENN/MADD domain containing 1A isoform 2 [Homo sapiens] 472 e-133
gi|188219541 DENN/MADD domain containing 1B isoform 2 [Homo sapi... 445 e-125
gi|21361991 DENN/MADD domain containing 2D [Homo sapiens] 130 6e-30
gi|154813195 DENN/MADD domain containing 2A [Homo sapiens] 130 6e-30
gi|47132529 suppression of tumorigenicity 5 isoform 1 [Homo sapi... 126 7e-29
gi|47132532 suppression of tumorigenicity 5 isoform 1 [Homo sapi... 126 7e-29
gi|21264614 suppression of tumorigenicity 5 isoform 2 [Homo sapi... 126 7e-29
gi|121949817 DENN/MADD domain containing 2C [Homo sapiens] 122 2e-27
gi|239735519 SET binding factor 1 [Homo sapiens] 73 1e-12
gi|94818781 DENN/MADD domain containing 4C [Homo sapiens] 72 2e-12
gi|29788755 SET binding factor 2 [Homo sapiens] 71 3e-12
gi|50345870 DENN/MADD domain containing 3 [Homo sapiens] 70 1e-11
gi|44889475 RAB6 interacting protein 1 [Homo sapiens] 65 2e-10
gi|221307568 DENN/MADD domain containing 4A isoform 1 [Homo sapi... 64 7e-10
gi|221307566 DENN/MADD domain containing 4A isoform 2 [Homo sapi... 64 7e-10
gi|122891862 DENN/MADD domain containing 5B [Homo sapiens] 63 9e-10
gi|148922920 DENN/MADD domain containing 4B [Homo sapiens] 62 2e-09
gi|209863002 MAP-kinase activating death domain-containing prote... 58 3e-08
gi|209862998 MAP-kinase activating death domain-containing prote... 58 3e-08
gi|209862994 MAP-kinase activating death domain-containing prote... 58 3e-08
gi|18860873 MAP-kinase activating death domain-containing protei... 58 3e-08
gi|209862987 MAP-kinase activating death domain-containing prote... 58 3e-08
gi|209862983 MAP-kinase activating death domain-containing prote... 58 3e-08
gi|209862979 MAP-kinase activating death domain-containing prote... 58 3e-08
gi|209862975 MAP-kinase activating death domain-containing prote... 58 3e-08
gi|209862971 MAP-kinase activating death domain-containing prote... 58 3e-08
gi|209571517 MAP-kinase activating death domain-containing prote... 58 3e-08
>gi|113205087 DENN/MADD domain containing 1C [Homo sapiens]
Length = 801
Score = 1616 bits (4184), Expect = 0.0
Identities = 801/801 (100%), Positives = 801/801 (100%)
Query: 1 MESRAEGGSPAVFDWFFEAACPASLQEDPPILRQFPPDFRDQEAMQMVPKFCFPFDVERE 60
MESRAEGGSPAVFDWFFEAACPASLQEDPPILRQFPPDFRDQEAMQMVPKFCFPFDVERE
Sbjct: 1 MESRAEGGSPAVFDWFFEAACPASLQEDPPILRQFPPDFRDQEAMQMVPKFCFPFDVERE 60
Query: 61 PPSPAVQHFTFALTDLAGNRRFGFCRLRAGTQSCLCILSHLPWFEVFYKLLNTVGDLLAQ 120
PPSPAVQHFTFALTDLAGNRRFGFCRLRAGTQSCLCILSHLPWFEVFYKLLNTVGDLLAQ
Sbjct: 61 PPSPAVQHFTFALTDLAGNRRFGFCRLRAGTQSCLCILSHLPWFEVFYKLLNTVGDLLAQ 120
Query: 121 DQVTEAEELLQNLFQQSLSGPQASVGLELGSGVTVSSGQGIPPPTRGNSKPLSCFVAPDS 180
DQVTEAEELLQNLFQQSLSGPQASVGLELGSGVTVSSGQGIPPPTRGNSKPLSCFVAPDS
Sbjct: 121 DQVTEAEELLQNLFQQSLSGPQASVGLELGSGVTVSSGQGIPPPTRGNSKPLSCFVAPDS 180
Query: 181 GRLPSIPENRNLTELVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALLYP 240
GRLPSIPENRNLTELVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALLYP
Sbjct: 181 GRLPSIPENRNLTELVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALLYP 240
Query: 241 MRWEHVLIPTLPPHLLDYCCAPMPYLIGVHASLAERVREKALEDVVVLNVDANTLETTFN 300
MRWEHVLIPTLPPHLLDYCCAPMPYLIGVHASLAERVREKALEDVVVLNVDANTLETTFN
Sbjct: 241 MRWEHVLIPTLPPHLLDYCCAPMPYLIGVHASLAERVREKALEDVVVLNVDANTLETTFN 300
Query: 301 DVQALPPDVVSLLRLRLRKVALAPGEGVSRLFLKAQALLFGGYRDALVCSPGQPVTFSEE 360
DVQALPPDVVSLLRLRLRKVALAPGEGVSRLFLKAQALLFGGYRDALVCSPGQPVTFSEE
Sbjct: 301 DVQALPPDVVSLLRLRLRKVALAPGEGVSRLFLKAQALLFGGYRDALVCSPGQPVTFSEE 360
Query: 361 VFLAQKPGAPLQAFHRRAVHLQLFKQFIEARLEKLNKGEGFSDQFEQEITGCGASSGALR 420
VFLAQKPGAPLQAFHRRAVHLQLFKQFIEARLEKLNKGEGFSDQFEQEITGCGASSGALR
Sbjct: 361 VFLAQKPGAPLQAFHRRAVHLQLFKQFIEARLEKLNKGEGFSDQFEQEITGCGASSGALR 420
Query: 421 SYQLWADNLKKGGGALLHSVKAKTQPAVKNMYRSAKSGLKGVQSLLMYKDGDSVLQRGGS 480
SYQLWADNLKKGGGALLHSVKAKTQPAVKNMYRSAKSGLKGVQSLLMYKDGDSVLQRGGS
Sbjct: 421 SYQLWADNLKKGGGALLHSVKAKTQPAVKNMYRSAKSGLKGVQSLLMYKDGDSVLQRGGS 480
Query: 481 LRAPALPSRSDRLQQRLPITQHFGKNRPLRPSRRRQLEEGTSEPPGAGTPPLSPEDEGCP 540
LRAPALPSRSDRLQQRLPITQHFGKNRPLRPSRRRQLEEGTSEPPGAGTPPLSPEDEGCP
Sbjct: 481 LRAPALPSRSDRLQQRLPITQHFGKNRPLRPSRRRQLEEGTSEPPGAGTPPLSPEDEGCP 540
Query: 541 WAEEALDSSFLGSGEELDLLSEILDSLSMGAKSAGSLRPSQSLDCCHRGDLDSCFSLPNI 600
WAEEALDSSFLGSGEELDLLSEILDSLSMGAKSAGSLRPSQSLDCCHRGDLDSCFSLPNI
Sbjct: 541 WAEEALDSSFLGSGEELDLLSEILDSLSMGAKSAGSLRPSQSLDCCHRGDLDSCFSLPNI 600
Query: 601 PRWQPDDKKLPEPEPQPLSLPSLQNASSLDATSSSKDSRSQLIPSESDQEVTSPSQSSTA 660
PRWQPDDKKLPEPEPQPLSLPSLQNASSLDATSSSKDSRSQLIPSESDQEVTSPSQSSTA
Sbjct: 601 PRWQPDDKKLPEPEPQPLSLPSLQNASSLDATSSSKDSRSQLIPSESDQEVTSPSQSSTA 660
Query: 661 SADPSIWGDPKPSPLTEPLILHLTPSHKAAEDSTAQENPTPWLSTAPTEPSPPESPQILA 720
SADPSIWGDPKPSPLTEPLILHLTPSHKAAEDSTAQENPTPWLSTAPTEPSPPESPQILA
Sbjct: 661 SADPSIWGDPKPSPLTEPLILHLTPSHKAAEDSTAQENPTPWLSTAPTEPSPPESPQILA 720
Query: 721 PTKPNFDIAWTSQPLDPSSDPSSLEDPRARPPKALLAERAHLQPREEPGALNSPATPTSN 780
PTKPNFDIAWTSQPLDPSSDPSSLEDPRARPPKALLAERAHLQPREEPGALNSPATPTSN
Sbjct: 721 PTKPNFDIAWTSQPLDPSSDPSSLEDPRARPPKALLAERAHLQPREEPGALNSPATPTSN 780
Query: 781 CQKSQPSSRPRVADLKKCFEG 801
CQKSQPSSRPRVADLKKCFEG
Sbjct: 781 CQKSQPSSRPRVADLKKCFEG 801
>gi|218563726 DENN/MADD domain containing 1B isoform 1 [Homo
sapiens]
Length = 755
Score = 483 bits (1243), Expect = e-136
Identities = 278/601 (46%), Positives = 366/601 (60%), Gaps = 46/601 (7%)
Query: 1 MESRAEGGSPAVFDWFFEAACPASLQEDPPILRQFPPDFRDQEAMQMVPKFCFPFDVERE 60
M+ R + FD + C AS EDP +L +FP DF DQE +Q VPKFCFPFDVER
Sbjct: 1 MDCRTKANPDRTFDLVLKVKCHASENEDPVVLWKFPEDFGDQEILQSVPKFCFPFDVERV 60
Query: 61 PPSPAVQHFTFALTDLAGNRRFGFCRLRAGTQSCLCILSHLPWFEVFYKLLNTVGDLLAQ 120
+ QHFTF LTD+ +RFGFCRL +G CLCILS+LPWFEV+YKLLNT+ D LA+
Sbjct: 61 SQNQVGQHFTFVLTDIESKQRFGFCRLTSGGTICLCILSYLPWFEVYYKLLNTLADYLAK 120
Query: 121 DQVTEAEELLQNLFQQSLSGPQASVGLELGSGVTVSSGQGIPPPTRGNSKPLSCFVAPDS 180
+ + E L++L+ + V L + S F+APD
Sbjct: 121 ELENDLNETLRSLYNHPVPKANTPVNLSVHS----------------------YFIAPDV 158
Query: 181 GRLPSIPENRNLTELVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALLYP 240
LP+IPE+RNLTE VAV N++ L+A++L ERR+++ +SKLSTLT+C+H S ALLYP
Sbjct: 159 TGLPTIPESRNLTEYFVAVDVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYP 218
Query: 241 MRWEHVLIPTLPPHLLDYCCAPMPYLIGVHASLAERVREKALEDVVVLNVDANTLETTFN 300
M W+H+ IP LPPHLLDYCCAPMPYLIG+H+SL ERV+ K+LEDVV+LNVD NTLE+ F+
Sbjct: 219 MYWQHIYIPVLPPHLLDYCCAPMPYLIGIHSSLIERVKNKSLEDVVMLNVDTNTLESPFS 278
Query: 301 DVQALPPDVVSLLRLRLRKVALAPGEGVSRLFLKAQALLFGGYRDALVCSPGQPVTFSEE 360
D+ LP DVVS L+ +L+K + A G+GV+R FL+AQA LFG YRDAL PG+P+TF EE
Sbjct: 279 DLNNLPSDVVSALKNKLKKQSTATGDGVARAFLRAQAALFGSYRDALRYKPGEPITFCEE 338
Query: 361 VFLAQKPGAPLQAFHRRAVHLQLFKQFIEARLEKLNKGEGFSDQFEQEITGCGASSGALR 420
F+ + + ++ F A++LQLFKQFI+ RL KLN G GFSD FE+EIT G G R
Sbjct: 339 SFVKHR-SSVMKQFLETAINLQLFKQFIDGRLAKLNAGRGFSDVFEEEITSGGFCGGNPR 397
Query: 421 SYQLWADNLKKGGGALLHSVKAKTQPAVKNMYRSAKS----GLKGVQSLLMYKDGDSVLQ 476
SYQ W +KK GGAL ++ K PAV+ Y+ AK+ GLK V+S L +K+ +
Sbjct: 398 SYQQWVHTVKK-GGALFNTAMTKATPAVRTAYKFAKNHAKLGLKEVKSKLKHKENEEDYG 456
Query: 477 RGGS----LRAPALPSRSDRLQQRLPITQHFGKNRPLRPSRRRQLEEGTSEPPGAGTPPL 532
S L + ++ + Q K RPL+ S L + + L
Sbjct: 457 TCSSSVQYTPVYKLHNEKGGNSEKRKLAQARLK-RPLK-SLDGALYDDEDDDDIERASKL 514
Query: 533 SPED--EGCPWAEEALDS-------SFLGSGEELDLLSEILDSLSMGAKSAGSLRPSQSL 583
S ED E + E+ DS + G E+DLL EILD+LS + G L ++SL
Sbjct: 515 SSEDGEEASAYLYESDDSVETRVKTPYSG---EMDLLGEILDTLSTHSSDQGKLAAAKSL 571
Query: 584 D 584
D
Sbjct: 572 D 572
>gi|55749779 DENN/MADD domain containing 1A isoform 1 [Homo sapiens]
Length = 1009
Score = 473 bits (1216), Expect = e-133
Identities = 320/836 (38%), Positives = 430/836 (51%), Gaps = 119/836 (14%)
Query: 1 MESRAEGGSPAVFDWFFEAACPAS--LQEDPPILRQFPPDFRDQEAMQMVPKFCFPFDVE 58
M SR + F+ + E A P + DP + RQFP D+ DQE +Q + KFCFPF V+
Sbjct: 1 MGSRIKQNPETTFEVYVEVAYPRTGGTLSDPEVQRQFPEDYSDQEVLQTLTKFCFPFYVD 60
Query: 59 REPPSPAVQHFTFALTDLAGNRRFGFCRLRAGTQSCLCILSHLPWFEVFYKLLNTVGDLL 118
S Q+FTF LTD+ +RFGFCRL +G +SC CILS+LPWFEVFYKLLN + D
Sbjct: 61 SLTVSQVGQNFTFVLTDIDSKQRFGFCRLSSGAKSCFCILSYLPWFEVFYKLLNILADYT 120
Query: 119 AQDQVTEAEELLQNLFQQSLSGPQASVGLELGSGVTVSSGQGIPPPTRGNSKPLSCFVAP 178
+ Q + ELL+ L + + P SV L + S TV P
Sbjct: 121 TKRQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTV----------------------P 158
Query: 179 DSGRLPSIPENRNLTELVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALL 238
D+ LPSIPENRNLTE VAV N++ L+A++L ERR+L+ SKLSTLT+C+H S A+L
Sbjct: 159 DTRELPSIPENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAML 218
Query: 239 YPMRWEHVLIPTLPPHLLDYCCAPMPYLIGVHASLAERVREKALEDVVVLNVDANTLETT 298
YPM W+HV IP LPPHLLDYCCAPMPYLIG+H SL E+VR AL+DVV+LNVD NTLET
Sbjct: 219 YPMYWQHVYIPVLPPHLLDYCCAPMPYLIGIHLSLMEKVRNMALDDVVILNVDTNTLETP 278
Query: 299 FNDVQALPPDVVSLLRLRLRKVALAPGEGVSRLFLKAQALLFGGYRDALVCSPGQPVTFS 358
F+D+Q+LP DV+S L+ RL+KV+ G+GV+R FLKAQA FG YR+AL P +P+TF
Sbjct: 279 FDDLQSLPNDVISSLKNRLKKVSTTTGDGVARAFLKAQAAFFGSYRNALKIEPEEPITFC 338
Query: 359 EEVFLAQKPGAPLQAFHRRAVHLQLFKQFIEARLEKLNKGEGFSDQFEQEITGCGASSGA 418
EE F++ ++ F + A LQLFKQFI+ RL+ LN GEGFSD FE+EI G +G+
Sbjct: 339 EEAFVSHYRSGAMRQFLQNATQLQLFKQFIDGRLDLLNSGEGFSDVFEEEI-NMGEYAGS 397
Query: 419 LRSYQLWADNLKKGGGALLHSVKAKTQPAVKNMYR----SAKSGLKGVQSLLMYKDGDSV 474
+ Y W ++KG GA+L++VK K PA+K +Y+ AK G+K V++ L KD +
Sbjct: 398 DKLYHQWLSTVRKGSGAILNTVKTKANPAMKTVYKFAKDHAKMGIKEVKNRLKQKD---I 454
Query: 475 LQRG----------GSLRAPALPSRSDRLQQ-RLPITQHFGKNRPLRPSRRRQLEEGTSE 523
+ G + +P + ++ +L++ R PIT HFG+ RP RP ++ + +
Sbjct: 455 AENGCAPTPEEQLPKTAPSPLVEAKDPKLREDRRPITVHFGQVRPPRPHVVKRPKSNIA- 513
Query: 524 PPGAGTPPLSPEDEGCPWAEEALDSSFLGSGEE------------------------LDL 559
G T SPE P L S G+E +DL
Sbjct: 514 VEGRRTSVPSPEQ---PQPYRTLRESDSAEGDEAESPEQQVRKSTGPVPAPPDRAASIDL 570
Query: 560 LSEILDSLSM--------GAKSAGSLRPSQSLD------CCHRGDLDSC----------- 594
L ++ +L M AKS LR + L R DL
Sbjct: 571 LEDVFSNLDMEAALQPLGQAKSLEDLRAPKDLREQPGTFDYQRLDLGGSERSRGVTVALK 630
Query: 595 FSLPNIPRWQ--PDDKKLP-EPEPQPLSLPSLQNASSLDATSSSKDSRSQLIPSESDQEV 651
+ P W DD +P +P PS +SL ++ S L PS+ +EV
Sbjct: 631 LTHPYNKLWSLGQDDMAIPSKPPAASPEKPSALLGNSLALPRRPQNRDSILNPSDK-EEV 689
Query: 652 TSPSQSSTASADPSIWGDPK-----PSPLTEPLILHLT------PSHKAAEDSTAQENPT 700
+P+ S P P+ P P+ P L S + D + +
Sbjct: 690 PTPTLGSITIPRPQGRKTPELGIVPPPPIPRPAKLQAAGAALGDVSERLQTDRDRRAALS 749
Query: 701 PWLSTAPTEPSPPESPQILAPTKPNFDIAWTSQP-----LDPSSDPSSLEDPRARP 751
P L P E +L P P A TS LDP S S +RP
Sbjct: 750 PGLLPGVVPQGPTE---LLQPLSPGPGAAGTSSDALLALLDPLSTAWSGSTLPSRP 802
>gi|55749789 DENN/MADD domain containing 1A isoform 2 [Homo sapiens]
Length = 559
Score = 472 bits (1215), Expect = e-133
Identities = 253/528 (47%), Positives = 336/528 (63%), Gaps = 43/528 (8%)
Query: 1 MESRAEGGSPAVFDWFFEAACPAS--LQEDPPILRQFPPDFRDQEAMQMVPKFCFPFDVE 58
M SR + F+ + E A P + DP + RQFP D+ DQE +Q + KFCFPF V+
Sbjct: 1 MGSRIKQNPETTFEVYVEVAYPRTGGTLSDPEVQRQFPEDYSDQEVLQTLTKFCFPFYVD 60
Query: 59 REPPSPAVQHFTFALTDLAGNRRFGFCRLRAGTQSCLCILSHLPWFEVFYKLLNTVGDLL 118
S Q+FTF LTD+ +RFGFCRL +G +SC CILS+LPWFEVFYKLLN + D
Sbjct: 61 SLTVSQVGQNFTFVLTDIDSKQRFGFCRLSSGAKSCFCILSYLPWFEVFYKLLNILADYT 120
Query: 119 AQDQVTEAEELLQNLFQQSLSGPQASVGLELGSGVTVSSGQGIPPPTRGNSKPLSCFVAP 178
+ Q + ELL+ L + + P SV L + S TV P
Sbjct: 121 TKRQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTV----------------------P 158
Query: 179 DSGRLPSIPENRNLTELVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALL 238
D+ LPSIPENRNLTE VAV N++ L+A++L ERR+L+ SKLSTLT+C+H S A+L
Sbjct: 159 DTRELPSIPENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAML 218
Query: 239 YPMRWEHVLIPTLPPHLLDYCCAPMPYLIGVHASLAERVREKALEDVVVLNVDANTLETT 298
YPM W+HV IP LPPHLLDYCCAPMPYLIG+H SL E+VR AL+DVV+LNVD NTLET
Sbjct: 219 YPMYWQHVYIPVLPPHLLDYCCAPMPYLIGIHLSLMEKVRNMALDDVVILNVDTNTLETP 278
Query: 299 FNDVQALPPDVVSLLRLRLRKVALAPGEGVSRLFLKAQALLFGGYRDALVCSPGQPVTFS 358
F+D+Q+LP DV+S L+ RL+KV+ G+GV+R FLKAQA FG YR+AL P +P+TF
Sbjct: 279 FDDLQSLPNDVISSLKNRLKKVSTTTGDGVARAFLKAQAAFFGSYRNALKIEPEEPITFC 338
Query: 359 EEVFLAQKPGAPLQAFHRRAVHLQLFKQFIEARLEKLNKGEGFSDQFEQEITGCGASSGA 418
EE F++ ++ F + A LQLFKQFI+ RL+ LN GEGFSD FE+EI G +G+
Sbjct: 339 EEAFVSHYRSGAMRQFLQNATQLQLFKQFIDGRLDLLNSGEGFSDVFEEEI-NMGEYAGS 397
Query: 419 LRSYQLWADNLKKGGGALLHSVKAKTQPAVKNMYR----SAKSGLKGVQSLLMYKDGDSV 474
+ Y W ++KG GA+L++VK K PA+K +Y+ AK G+K V++ L KD +
Sbjct: 398 DKLYHQWLSTVRKGSGAILNTVKTKANPAMKTVYKFAKDHAKMGIKEVKNRLKQKD---I 454
Query: 475 LQRG----------GSLRAPALPSRSDRLQQ-RLPITQHFGKNRPLRP 511
+ G + +P + ++ +L++ R PIT HFG+ RP RP
Sbjct: 455 AENGCAPTPEEQLPKTAPSPLVEAKDPKLREDRRPITVHFGQVRPPRP 502
>gi|188219541 DENN/MADD domain containing 1B isoform 2 [Homo
sapiens]
Length = 426
Score = 445 bits (1144), Expect = e-125
Identities = 222/417 (53%), Positives = 289/417 (69%), Gaps = 3/417 (0%)
Query: 1 MESRAEGGSPAVFDWFFEAACPASLQEDPPILRQFPPDFRDQEAMQMVPKFCFPFDVERE 60
M+ R + FD + C AS EDP +L +FP DF DQE +Q VPKFCFPFDVER
Sbjct: 1 MDCRTKANPDRTFDLVLKVKCHASENEDPVVLWKFPEDFGDQEILQSVPKFCFPFDVERV 60
Query: 61 PPSPAVQHFTFALTDLAGNRRFGFCRLRAGTQSCLCILSHLPWFEVFYKLLNTVGDLLAQ 120
+ QHFTF LTD+ +RFGFCRL +G CLCILS+LPWFEV+YKLLNT+ D LA+
Sbjct: 61 SQNQVGQHFTFVLTDIESKQRFGFCRLTSGGTICLCILSYLPWFEVYYKLLNTLADYLAK 120
Query: 121 DQVTEAEELLQNLFQQSLSGPQASVGLELGSGVTVSSGQGIPPPTRGNSKPLSCFVAPDS 180
+ + E L++L+ + V L + + ++ Q + P S F+APD
Sbjct: 121 ELENDLNETLRSLYNHPVPKANTPVNLSVNQEIFIACEQVLKDQPA--LVPHSYFIAPDV 178
Query: 181 GRLPSIPENRNLTELVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALLYP 240
LP+IPE+RNLTE VAV N++ L+A++L ERR+++ +SKLSTLT+C+H S ALLYP
Sbjct: 179 TGLPTIPESRNLTEYFVAVDVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYP 238
Query: 241 MRWEHVLIPTLPPHLLDYCCAPMPYLIGVHASLAERVREKALEDVVVLNVDANTLETTFN 300
M W+H+ IP LPPHLLDYCCAPMPYLIG+H+SL ERV+ K+LEDVV+LNVD NTLE+ F+
Sbjct: 239 MYWQHIYIPVLPPHLLDYCCAPMPYLIGIHSSLIERVKNKSLEDVVMLNVDTNTLESPFS 298
Query: 301 DVQALPPDVVSLLRLRLRKVALAPGEGVSRLFLKAQALLFGGYRDALVCSPGQPVTFSEE 360
D+ LP DVVS L+ +L+K + A G+GV+R FL+AQA LFG YRDAL PG+P+TF EE
Sbjct: 299 DLNNLPSDVVSALKNKLKKQSTATGDGVARAFLRAQAALFGSYRDALRYKPGEPITFCEE 358
Query: 361 VFLAQKPGAPLQAFHRRAVHLQLFKQFIEARLEKLNKGEGFSDQFEQEITGCGASSG 417
F+ + + ++ F A++LQLFKQFI+ RL KLN G GFSD FE+EIT G G
Sbjct: 359 SFVKHR-SSVMKQFLETAINLQLFKQFIDGRLAKLNAGRGFSDVFEEEITSGGFCGG 414
>gi|21361991 DENN/MADD domain containing 2D [Homo sapiens]
Length = 471
Score = 130 bits (326), Expect = 6e-30
Identities = 117/434 (26%), Positives = 194/434 (44%), Gaps = 73/434 (16%)
Query: 16 FFEAACPASLQE-------DPPILRQFPP--------DFRDQEAMQMVPKFCFPFDVE-- 58
FFE SL++ +P I QFP ++ ++ +P FCFP E
Sbjct: 53 FFEYLLVVSLKKKRSEDDYEPIITYQFPKRENLLRGQQEEEERLLKAIPLFCFPDGNEWA 112
Query: 59 --REPPSPAVQHFTFALTDLAGNRRFGFCR--LRAGTQSCL----CILSHLPWFEVFYKL 110
E P + F+F LT++ G+R+ G+CR L AG L CI+S + F +F K+
Sbjct: 113 SLTEYPR---ETFSFVLTNVDGSRKIGYCRRLLPAGPGPRLPKVYCIISCIGCFGLFSKI 169
Query: 111 LNTVGDLLAQDQVTEAEELLQNLFQQSLSGPQASVGLELGSGVTVSSGQGIPPPTRGNSK 170
L D+V + ++ + + G + + P G +
Sbjct: 170 L---------DEVEKRHQISMAVIYPFMQGLREAAF-----------------PAPGKTV 203
Query: 171 PLSCFVAPDSGR--------LPSIPENRNLTELVVAVTDENIVGLFAALLAERRVLLTAS 222
L F+ PDSG L S E+ + + L+ ++ E I+ +FA+ + ER+++ A
Sbjct: 204 TLKSFI-PDSGTEFISLTRPLDSHLEHVDFSSLLHCLSFEQILQIFASAVLERKIIFLAE 262
Query: 223 KLSTLTSCVHASCALLYPMRWEHVLIPTLPPHLLDYCCAPMPYLIGVHASLAERVREKAL 282
LSTL+ C+HA+ ALLYP W H IP +P LL C P P+++GV + V + +
Sbjct: 263 GLSTLSQCIHAAAALLYPFSWAHTYIPVVPESLLATVCCPTPFMVGVQMRFQQEVMDSPM 322
Query: 283 EDVVVLNVDANT-LETTFNDVQALPP----DVVSLLRLRLRKVALAP--GEGVSRLFLKA 335
E+V+++N+ T L + ++ LPP D++ L + ++ A E VS F++
Sbjct: 323 EEVLLVNLCEGTFLMSVGDEKDILPPKLQDDILDSLGQGINELKTAEQINEHVSGPFVQF 382
Query: 336 QALLFGGYRDALVCSPGQPVTFSEEVFLAQKPGAPLQAFHRRAVHLQLFKQFIEARLEKL 395
+ G Y + F E F + F ++ V QLF FI+ +
Sbjct: 383 FVKIVGHYASYIKREANGQGHFQERSFCKALTSKTNRRFVKKFVKTQLFSLFIQEAEKSK 442
Query: 396 NKGEGFSDQFEQEI 409
N G+ F+Q+I
Sbjct: 443 NPPAGY---FQQKI 453
>gi|154813195 DENN/MADD domain containing 2A [Homo sapiens]
Length = 1009
Score = 130 bits (326), Expect = 6e-30
Identities = 111/415 (26%), Positives = 187/415 (45%), Gaps = 54/415 (13%)
Query: 29 PPILRQFPPDFRD--------QEAMQMVPKFCFPFDVEREPPSPAVQH-FTFALTDLAGN 79
P + +QFP ++ ++ +P+FCFP + P F+F LT G+
Sbjct: 584 PELTQQFPLKLERSFKFMREAEDQLKAIPQFCFPDAKDWVPVQQFTSETFSFVLTGEDGS 643
Query: 80 RRFGFCR--LRAGTQSCL----CILSHLPWFEVFYKLLNTVGDLLAQDQVTEAEELLQNL 133
RRFG+CR L G L CI+S L F +F ++L+ V + + + L+Q L
Sbjct: 644 RRFGYCRRLLPGGKGKRLPEVYCIVSRLGCFSLFSRILDEV-----EKRRGISPALVQPL 698
Query: 134 FQQSLSGPQASVGLELGSGVTVSSGQGIPPPTRGNSKPLSCFVAPDSGRLPSIPENRNLT 193
+ + P ++G T+ +P G+ + P RL E+ +
Sbjct: 699 MRSVMEAPFPALGK------TILVKNFLP----GSGTEVIELCRPLDSRL----EHVDFE 744
Query: 194 ELVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALLYPMRWEHVLIPTLPP 253
L +++ ++V +FA+LL ERRV+ A KLS L+ C HA AL+YP W+H IP LPP
Sbjct: 745 SLFSSLSVRHLVCVFASLLLERRVIFIADKLSILSKCCHAMVALIYPFAWQHTYIPVLPP 804
Query: 254 HLLDYCCAPMPYLIGVHASLAERVREKALEDVVVLNVDANTLETTFNDVQALPPDVVSL- 312
++D C+P P+LIG+ +S +RE LE+V+V+++ + +D ++ P + +
Sbjct: 805 AMVDIVCSPTPFLIGLLSSSLPLLRELPLEEVLVVDLVNSRFLRQMDDEDSILPRKLQVA 864
Query: 313 ---LRLRLRKVALAPGEG----------------VSRLFLKAQALLFGGYRDALVCSPGQ 353
+ + ++A EG VS F++ + G Y L +
Sbjct: 865 LEHILEQRNELACEQDEGPLDGRHGPESSPLNEVVSEAFVRFFVEIVGHYSLFLTSGERE 924
Query: 354 PVTFSEEVFLAQKPGAPLQAFHRRAVHLQLFKQFIEARLEKLNKGEGFSDQFEQE 408
T E F L+ F + Q+F+ FI+ R + +G + QE
Sbjct: 925 ERTLQREAFRKAVSSKSLRHFLEVFMETQMFRGFIQERELRRQDAKGLFEVRAQE 979
>gi|47132529 suppression of tumorigenicity 5 isoform 1 [Homo sapiens]
Length = 1137
Score = 126 bits (317), Expect = 7e-29
Identities = 110/406 (27%), Positives = 181/406 (44%), Gaps = 49/406 (12%)
Query: 29 PPILRQFPPDFRD-------QEAMQMVPKFCFPFDVEREPPSP-AVQHFTFALTDLAGNR 80
P + QFP R +E ++ +P+FCFP + P S + + F+F LT G+R
Sbjct: 716 PEVSYQFPKLDRPTKQMREAEERLKAIPQFCFPDAKDWLPVSEYSSETFSFMLTGEDGSR 775
Query: 81 RFGFCR--LRAGTQSCL----CILSHLPWFEVFYKLLNTVGDLLAQDQVTEAEELLQNLF 134
RFG+CR L +G L C++S L F +F K+L+ V + +++L
Sbjct: 776 RFGYCRRLLPSGKGPRLPEVYCVISRLGCFGLFSKVLDEV-ERRRGISAALVYPFMRSLM 834
Query: 135 QQSLSGPQASVGLELGSGVTVSSGQGIPPPTRGNSKPLSCFVAPDSGRLPSIPENRNLTE 194
+ P G T+ +P G + P RL E+ +
Sbjct: 835 ESPFPAP----------GKTIKVKTFLP----GAGNEVLELRRPMDSRL----EHVDFEC 876
Query: 195 LVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALLYPMRWEHVLIPTLPPH 254
L ++ ++ +FA+LL ERRV+ A KLSTL+SC HA ALLYP W+H IP LP
Sbjct: 877 LFTCLSVRQLIRIFASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLPAS 936
Query: 255 LLDYCCAPMPYLIGVHASLAERVREKALEDVVVLNVDANTLETTFNDVQALPPDVV--SL 312
++D C P P+L+G+ +S +++E +E+ +++N+ ++ +D L P + +L
Sbjct: 937 MIDIVCCPTPFLVGLLSSSLPKLKELPVEEALMVNLGSDRFIRQMDDEDTLLPRKLQAAL 996
Query: 313 LRLRLRKVALAPGEG--------------VSRLFLKAQALLFGGYRDALVCSPGQPVTFS 358
+ RK L + VS +F++ G Y L S F
Sbjct: 997 EQALERKNELISQDSDSDSDDECNTLNGLVSEVFIRFFVETVGHYSLFLTQSEKGERAFQ 1056
Query: 359 EEVFLAQKPGAPLQAFHRRAVHLQLFKQFIEARLEKLNKGEGFSDQ 404
E F ++ F + Q+F FI+ R + + +G +Q
Sbjct: 1057 REAFRKSVASKSIRRFLEVFMESQMFAGFIQDRELRKCRAKGLFEQ 1102
>gi|47132532 suppression of tumorigenicity 5 isoform 1 [Homo sapiens]
Length = 1137
Score = 126 bits (317), Expect = 7e-29
Identities = 110/406 (27%), Positives = 181/406 (44%), Gaps = 49/406 (12%)
Query: 29 PPILRQFPPDFRD-------QEAMQMVPKFCFPFDVEREPPSP-AVQHFTFALTDLAGNR 80
P + QFP R +E ++ +P+FCFP + P S + + F+F LT G+R
Sbjct: 716 PEVSYQFPKLDRPTKQMREAEERLKAIPQFCFPDAKDWLPVSEYSSETFSFMLTGEDGSR 775
Query: 81 RFGFCR--LRAGTQSCL----CILSHLPWFEVFYKLLNTVGDLLAQDQVTEAEELLQNLF 134
RFG+CR L +G L C++S L F +F K+L+ V + +++L
Sbjct: 776 RFGYCRRLLPSGKGPRLPEVYCVISRLGCFGLFSKVLDEV-ERRRGISAALVYPFMRSLM 834
Query: 135 QQSLSGPQASVGLELGSGVTVSSGQGIPPPTRGNSKPLSCFVAPDSGRLPSIPENRNLTE 194
+ P G T+ +P G + P RL E+ +
Sbjct: 835 ESPFPAP----------GKTIKVKTFLP----GAGNEVLELRRPMDSRL----EHVDFEC 876
Query: 195 LVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALLYPMRWEHVLIPTLPPH 254
L ++ ++ +FA+LL ERRV+ A KLSTL+SC HA ALLYP W+H IP LP
Sbjct: 877 LFTCLSVRQLIRIFASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLPAS 936
Query: 255 LLDYCCAPMPYLIGVHASLAERVREKALEDVVVLNVDANTLETTFNDVQALPPDVV--SL 312
++D C P P+L+G+ +S +++E +E+ +++N+ ++ +D L P + +L
Sbjct: 937 MIDIVCCPTPFLVGLLSSSLPKLKELPVEEALMVNLGSDRFIRQMDDEDTLLPRKLQAAL 996
Query: 313 LRLRLRKVALAPGEG--------------VSRLFLKAQALLFGGYRDALVCSPGQPVTFS 358
+ RK L + VS +F++ G Y L S F
Sbjct: 997 EQALERKNELISQDSDSDSDDECNTLNGLVSEVFIRFFVETVGHYSLFLTQSEKGERAFQ 1056
Query: 359 EEVFLAQKPGAPLQAFHRRAVHLQLFKQFIEARLEKLNKGEGFSDQ 404
E F ++ F + Q+F FI+ R + + +G +Q
Sbjct: 1057 REAFRKSVASKSIRRFLEVFMESQMFAGFIQDRELRKCRAKGLFEQ 1102
>gi|21264614 suppression of tumorigenicity 5 isoform 2 [Homo
sapiens]
Length = 717
Score = 126 bits (317), Expect = 7e-29
Identities = 110/406 (27%), Positives = 181/406 (44%), Gaps = 49/406 (12%)
Query: 29 PPILRQFPPDFRD-------QEAMQMVPKFCFPFDVEREPPSP-AVQHFTFALTDLAGNR 80
P + QFP R +E ++ +P+FCFP + P S + + F+F LT G+R
Sbjct: 296 PEVSYQFPKLDRPTKQMREAEERLKAIPQFCFPDAKDWLPVSEYSSETFSFMLTGEDGSR 355
Query: 81 RFGFCR--LRAGTQSCL----CILSHLPWFEVFYKLLNTVGDLLAQDQVTEAEELLQNLF 134
RFG+CR L +G L C++S L F +F K+L+ V + +++L
Sbjct: 356 RFGYCRRLLPSGKGPRLPEVYCVISRLGCFGLFSKVLDEV-ERRRGISAALVYPFMRSLM 414
Query: 135 QQSLSGPQASVGLELGSGVTVSSGQGIPPPTRGNSKPLSCFVAPDSGRLPSIPENRNLTE 194
+ P G T+ +P G + P RL E+ +
Sbjct: 415 ESPFPAP----------GKTIKVKTFLP----GAGNEVLELRRPMDSRL----EHVDFEC 456
Query: 195 LVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALLYPMRWEHVLIPTLPPH 254
L ++ ++ +FA+LL ERRV+ A KLSTL+SC HA ALLYP W+H IP LP
Sbjct: 457 LFTCLSVRQLIRIFASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLPAS 516
Query: 255 LLDYCCAPMPYLIGVHASLAERVREKALEDVVVLNVDANTLETTFNDVQALPPDVV--SL 312
++D C P P+L+G+ +S +++E +E+ +++N+ ++ +D L P + +L
Sbjct: 517 MIDIVCCPTPFLVGLLSSSLPKLKELPVEEALMVNLGSDRFIRQMDDEDTLLPRKLQAAL 576
Query: 313 LRLRLRKVALAPGEG--------------VSRLFLKAQALLFGGYRDALVCSPGQPVTFS 358
+ RK L + VS +F++ G Y L S F
Sbjct: 577 EQALERKNELISQDSDSDSDDECNTLNGLVSEVFIRFFVETVGHYSLFLTQSEKGERAFQ 636
Query: 359 EEVFLAQKPGAPLQAFHRRAVHLQLFKQFIEARLEKLNKGEGFSDQ 404
E F ++ F + Q+F FI+ R + + +G +Q
Sbjct: 637 REAFRKSVASKSIRRFLEVFMESQMFAGFIQDRELRKCRAKGLFEQ 682
>gi|121949817 DENN/MADD domain containing 2C [Homo sapiens]
Length = 871
Score = 122 bits (305), Expect = 2e-27
Identities = 108/398 (27%), Positives = 182/398 (45%), Gaps = 47/398 (11%)
Query: 22 PASLQEDPPILRQFP-------PDFRD-QEAMQMVPKFCFPFDVEREPPSPAVQH-FTFA 72
P+ + P +++QFP +D +E ++++PKFCFP + P S F+F
Sbjct: 446 PSGISYIPQVIQQFPGKDDHGYKQSKDMEERLKVIPKFCFPDSKDWMPTSELKSETFSFV 505
Query: 73 LTDLAGNRRFGFCR--LRAGTQSCL----CILSHLPWFEVFYKLLNTVGDLLAQDQVTEA 126
LT G+R FG+C+ L G L C++S L F +F K+L D+V +
Sbjct: 506 LTGEDGSRWFGYCKKLLPVGKGKRLPEVYCMVSRLGCFNLFSKIL---------DEVEKR 556
Query: 127 EELLQNLFQQSLSGPQASVGLELGSGVTVSSGQGIPPPTRGNSKPLSCFVAPDSGRLPSI 186
E+ L + + G +TV S P G+ C P RL
Sbjct: 557 REMSPALVYPFMRSVMEAPFPAPGRTITVKSYL----PGAGDESIELC--RPLDSRL--- 607
Query: 187 PENRNLTELVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALLYPMRWEHV 246
E+ + L ++ +++ + A+LL ERRV+ A+ LSTL+ C HA A LYP W+H
Sbjct: 608 -EHVDFKCLFKCLSVCHLIRVCASLLLERRVIFVANSLSTLSKCGHAVVATLYPFTWQHT 666
Query: 247 LIPTLPPHLLDYCCAPMPYLIGVHASLAERVREKALEDVVVLNVDANT-LETTFNDVQAL 305
IP LP ++D C+P P+LIG+ + ++++ +E+V+++++ A+ L+ ++ + L
Sbjct: 667 YIPVLPASMIDIVCSPTPFLIGILSCSLPQLQDLPIEEVLIVDLCADKFLQEVSDEDEIL 726
Query: 306 PPDVVSLLR--LRLRKVALAPGEG----------VSRLFLKAQALLFGGYRDALVCSPGQ 353
PP + + L L R L + VS F++ L G Y + +
Sbjct: 727 PPKLQAALMQILEERNEILTQEQNFSQDVTLNSLVSEAFVRFFVELVGHYSLNMTVTERG 786
Query: 354 PVTFSEEVFLAQKPGAPLQAFHRRAVHLQLFKQFIEAR 391
F E F ++ F + Q+F FI+ R
Sbjct: 787 ERVFQREPFRKSHTSRSVRHFLDLFMETQMFAGFIQDR 824
>gi|239735519 SET binding factor 1 [Homo sapiens]
Length = 1893
Score = 72.8 bits (177), Expect = 1e-12
Identities = 114/481 (23%), Positives = 178/481 (37%), Gaps = 111/481 (23%)
Query: 31 ILRQFPP-DFRDQEAMQMVPKFCFPFD----VEREPPSPAVQHFTFALTDLAGNRRFGFC 85
IL++FP D+ D Q + FC P ER PP+ F LTD+ R + C
Sbjct: 27 ILQRFPEKDWEDNPFPQGIELFCQPSGWQLCPERNPPT----FFVAVLTDINSERHYCAC 82
Query: 86 --------------RLRAGTQ---------------------------SCLCILSHLPWF 104
R+ T+ L ++S L
Sbjct: 83 LTFWEPAEPSQETTRVEDATEREEEGDEGGQTHLSPTAPAPSAQLFAPKTLVLVSRLDHT 142
Query: 105 EVFYKLLNTVGDLLAQDQVTEAEELLQNLFQQSLSGPQASVGLELGSGVTVSSGQGIPPP 164
EVF L + + + E ++ NL +V L GS T+S G G
Sbjct: 143 EVFRNSLGLIYAIHVEGLNVCLENVIGNLLT-------CTVPLAGGSQRTISLGAG---D 192
Query: 165 TRGNSKPLSCFVAPDSGRLPSIPENRNLTELV---VAVTDENIVGLFAALLAERRVLLTA 221
+ PL+ S+P +R L+ + +T N++ LF A L E +VL +
Sbjct: 193 RQVIQTPLA----------DSLPVSRCSVALLFRQLGIT--NVLSLFCAALTEHKVLFLS 240
Query: 222 SKLSTLTSCVHASCALLYPMRWEHVLIPTLPPHLLDYCCAPMPYLIGVHASLAERVREKA 281
L ALL+P+R+ +P LP LL+ P P++IGV+A+ +E
Sbjct: 241 RSYQRLADACRGLLALLFPLRYSFTYVPILPAQLLEVLSTPTPFIIGVNAAFQAETQE-- 298
Query: 282 LEDVVVLNVDANTLETTFNDVQALPP----------DVVSLL---RLRLRKVALAP---- 324
L DV+V ++D T+ T + +PP V+S++ L L +A P
Sbjct: 299 LLDVIVADLDGGTV--TIPECVHIPPLPEPLQSQTHSVLSMVLDPELELADLAFPPPTTS 356
Query: 325 -------GEGVSRLFLKAQALLFGGYR---DALVCSPGQPVTFSEEVFLAQKPGAPLQAF 374
+ + +FL+ A L GYR + P + F + FL Q+ G F
Sbjct: 357 TSSLKMQDKELRAVFLRLFAQLLQGYRWCLHVVRIHPEPVIRFHKAAFLGQR-GLVEDDF 415
Query: 375 HRRAVHLQLFKQFIEARLEKLNKGEGFSDQFEQEITGCGASSG----ALRSYQLWADNLK 430
+ + F F+ R + F + E+ A LR Q A+ L
Sbjct: 416 LMKVLEGMAFAGFVSERGVPYRPTDLFDELVAHEVARMRADENHPQRVLRHVQELAEQLY 475
Query: 431 K 431
K
Sbjct: 476 K 476
>gi|94818781 DENN/MADD domain containing 4C [Homo sapiens]
Length = 1673
Score = 72.0 bits (175), Expect = 2e-12
Identities = 53/210 (25%), Positives = 88/210 (41%), Gaps = 29/210 (13%)
Query: 91 TQSCLCILSHLPWFEVFYKLLNTVGDLLAQDQ-----VTEAEELLQNLFQQSLSGPQASV 145
T C+C+LSH P+FE F K L + L +QN+ S P+ V
Sbjct: 73 TNKCICLLSHWPFFEAFRKFLMFIYKLSVSGPHPLPIEKHISHFMQNIPFPSPQRPRILV 132
Query: 146 GLELGSGVTVSSGQGIPPPTRGNSKPLSCFVAPDSGRLPSIPENRNLTELVVAVTDENIV 205
L + + +S P P G N + L++ + EN
Sbjct: 133 QLSVHDALILSQPVSTPLPLSG----------------------ANFSTLLMNLGPENCA 170
Query: 206 GLFAALLAERRVLLTASKLSTLTSCVHASCALLYPMRWEHVLIPTLPPHLLDYCCAPMPY 265
L +L E ++LL + + + LT A A+++P +W+ IP P L AP+P+
Sbjct: 171 TLLLFVLLESKILLHSLRPAVLTGVAEAVVAMIFPFQWQCPYIPLCPLSLAAVLSAPLPF 230
Query: 266 LIGVHASLAERVREKALEDVVVLNVDANTL 295
++GV + + +DVV +++D N L
Sbjct: 231 IVGVDSRYFD--LHDPPQDVVCIDLDTNML 258
>gi|29788755 SET binding factor 2 [Homo sapiens]
Length = 1849
Score = 71.2 bits (173), Expect = 3e-12
Identities = 99/421 (23%), Positives = 163/421 (38%), Gaps = 87/421 (20%)
Query: 31 ILRQFPP-DFRDQEAMQMVPKFCFP--FDVEREPPSPAVQHFTFALTDLAGNRRFGFCRL 87
I+++FP D+ D Q + FC P + + RE P F LTD+ +R + C
Sbjct: 27 IIQRFPQKDWDDTPFPQGIELFCQPGGWQLSRERKQPTF--FVVVLTDIDSDRHYCSCLT 84
Query: 88 -------RAGTQS----------------------CLCILSHLPWFEVFYKLLNTVGDLL 118
GT+ L ++S L + E+F L + +
Sbjct: 85 FYEAEINLQGTKKEEIEGEAKVSGLIQPAEVFAPKSLVLVSRLYYPEIFRACLGLIYTVY 144
Query: 119 AQDQVTEAEELLQNL---FQQSLSGPQASVGLELGSGVTVSSGQGIPPPTRGNSKPLSCF 175
E L+ NL + G Q L G + + P G S L
Sbjct: 145 VDSLNVSLESLIANLCACLVPAAGGSQKLFSLGAGDRQLIQTPLHDSLPITGTSVAL--- 201
Query: 176 VAPDSGRLPSIPENRNLTELVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASC 235
L + +N++ LF A+L E +VL ++ L+ A
Sbjct: 202 -------------------LFQQLGIQNVLSLFCAVLTENKVLFHSASFQRLSDACRALE 242
Query: 236 ALLYPMRWEHVLIPTLPPHLLDYCCAPMPYLIGVHASLAERVREKALEDVVVLNVDANTL 295
+L++P+++ + IP LP LL+ +P P++IGVH+ V E L DV++ ++D T+
Sbjct: 243 SLMFPLKYSYPYIPILPAQLLEVLSSPTPFIIGVHSVFKTDVHE--LLDVIIADLDGGTI 300
Query: 296 E-TTFNDVQALPPDVV----SLLRLRLR-------------KVALAPG----EGVSRLFL 333
+ + +LP ++ S L L L + AL+ + V +FL
Sbjct: 301 KIPECIHLSSLPEPLLHQTQSALSLILHPDLEVADHAFPPPRTALSHSKMLDKEVRAVFL 360
Query: 334 KAQALLFGGYRDA--LVCSPGQPVT-FSEEVFLAQKPGAPLQAFHRRAVHLQLFKQFIEA 390
+ A LF GYR L+ +PV F + FL Q+ G F + + F F+
Sbjct: 361 RLFAQLFQGYRSCLQLIRIHAEPVIHFHKTAFLGQR-GLVENDFLTKVLSGMAFAGFVSE 419
Query: 391 R 391
R
Sbjct: 420 R 420
>gi|50345870 DENN/MADD domain containing 3 [Homo sapiens]
Length = 1198
Score = 69.7 bits (169), Expect = 1e-11
Identities = 67/277 (24%), Positives = 115/277 (41%), Gaps = 54/277 (19%)
Query: 48 VPKFCFPFDV--EREPPSPAVQHFTFALTDLAGNRRFG------------FCRLRAGTQS 93
+P+ CFP V EP V HF LTD+ GNR +G +C T
Sbjct: 42 LPQLCFPGGVCVATEPKEDCV-HF-LVLTDVCGNRTYGVVAQYYRPLHDEYCFYNGKTHR 99
Query: 94 ---------CLCILSHLPWFEVFYKLLNTVGDLLAQDQVTEAEELLQNLFQQSLSGPQAS 144
+C++S P++ L+ + LL + E + +++ A
Sbjct: 100 ECPGCFVPFAVCVVSRFPYYNSLKDCLSCLLALLKPCKDFEVDSHIKDF--------AAK 151
Query: 145 VGLELGSGVTVSSGQGIPPPTRG------NSKPLSCFVAPDSGRLPSIPENRNLTELVVA 198
+ L IP P G N K L V P S + +L ++
Sbjct: 152 LSL-------------IPSPPPGPLHLVFNMKSLQ-IVLPARADPESPILDLDLHLPLLC 197
Query: 199 VTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALLYPMRWEHVLIPTLPPHLLDY 258
E ++ + +L E+R++ +S + LT A LYP++W+H +P L +LD+
Sbjct: 198 FRPEKVLQILTCILTEQRIVFFSSDWALLTLVTECFMAYLYPLQWQHPFVPILSDQMLDF 257
Query: 259 CCAPMPYLIGVHASLAERVREKALEDVVVLNVDANTL 295
AP +L+G H E V ++A + +V++N+D ++
Sbjct: 258 VMAPTSFLMGCHLDHFEEVSKEA-DGLVLINIDHGSI 293
>gi|44889475 RAB6 interacting protein 1 [Homo sapiens]
Length = 1287
Score = 65.5 bits (158), Expect = 2e-10
Identities = 38/117 (32%), Positives = 61/117 (52%), Gaps = 8/117 (6%)
Query: 161 IPPPTR-----GNSKPLSCFVAPDSGRLPSIPENRNLTELVVAVTDENIVGLFAALLAER 215
+PPP R G P+ C P + LP + + E+ + EN+ LF L E
Sbjct: 253 LPPPGRSLKFSGVYGPIIC-QRPSTNELPLF--DFPVKEVFELLGVENVFQLFTCALLEF 309
Query: 216 RVLLTASKLSTLTSCVHASCALLYPMRWEHVLIPTLPPHLLDYCCAPMPYLIGVHAS 272
++LL + L + AL++P +W+HV +P LP LL + AP+PYL+G+H++
Sbjct: 310 QILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILPASLLHFLDAPVPYLMGLHSN 366
>gi|221307568 DENN/MADD domain containing 4A isoform 1 [Homo
sapiens]
Length = 1906
Score = 63.5 bits (153), Expect = 7e-10
Identities = 50/210 (23%), Positives = 89/210 (42%), Gaps = 29/210 (13%)
Query: 91 TQSCLCILSHLPWFEVFYKLLNTVGDL-LAQDQVTEAEELLQNLFQQ----SLSGPQASV 145
T C+C+LSH P+F+ F K L + ++ V E+ + + + S P+ V
Sbjct: 309 TNKCICLLSHWPFFDAFRKFLTFLYRYSISGPHVLPIEKHISHFMHKVPFPSPQRPRILV 368
Query: 146 GLELGSGVTVSSGQGIPPPTRGNSKPLSCFVAPDSGRLPSIPENRNLTELVVAVTDENIV 205
L + +S P P G G+ ++ +N + EN V
Sbjct: 369 QLSPHDNLILSQPVSSPLPLSG-------------GKFSTLLQN---------LGPENAV 406
Query: 206 GLFAALLAERRVLLTASKLSTLTSCVHASCALLYPMRWEHVLIPTLPPHLLDYCCAPMPY 265
L + E ++L+ + + S LTS A ++++P W +P P L D AP P+
Sbjct: 407 TLLVFAVTEHKILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALADVLSAPCPF 466
Query: 266 LIGVHASLAERVREKALEDVVVLNVDANTL 295
++G+ + + DV ++VD NT+
Sbjct: 467 IVGIDSRYFDLYDPP--PDVSCVDVDTNTI 494
>gi|221307566 DENN/MADD domain containing 4A isoform 2 [Homo
sapiens]
Length = 1863
Score = 63.5 bits (153), Expect = 7e-10
Identities = 50/210 (23%), Positives = 89/210 (42%), Gaps = 29/210 (13%)
Query: 91 TQSCLCILSHLPWFEVFYKLLNTVGDL-LAQDQVTEAEELLQNLFQQ----SLSGPQASV 145
T C+C+LSH P+F+ F K L + ++ V E+ + + + S P+ V
Sbjct: 309 TNKCICLLSHWPFFDAFRKFLTFLYRYSISGPHVLPIEKHISHFMHKVPFPSPQRPRILV 368
Query: 146 GLELGSGVTVSSGQGIPPPTRGNSKPLSCFVAPDSGRLPSIPENRNLTELVVAVTDENIV 205
L + +S P P G G+ ++ +N + EN V
Sbjct: 369 QLSPHDNLILSQPVSSPLPLSG-------------GKFSTLLQN---------LGPENAV 406
Query: 206 GLFAALLAERRVLLTASKLSTLTSCVHASCALLYPMRWEHVLIPTLPPHLLDYCCAPMPY 265
L + E ++L+ + + S LTS A ++++P W +P P L D AP P+
Sbjct: 407 TLLVFAVTEHKILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALADVLSAPCPF 466
Query: 266 LIGVHASLAERVREKALEDVVVLNVDANTL 295
++G+ + + DV ++VD NT+
Sbjct: 467 IVGIDSRYFDLYDPP--PDVSCVDVDTNTI 494
>gi|122891862 DENN/MADD domain containing 5B [Homo sapiens]
Length = 1274
Score = 63.2 bits (152), Expect = 9e-10
Identities = 38/116 (32%), Positives = 59/116 (50%), Gaps = 8/116 (6%)
Query: 161 IPPPTR-----GNSKPLSCFVAPDSGRLPSIPENRNLTELVVAVTDENIVGLFAALLAER 215
+PPP R G +P+ C P LP + L E + EN+V +F +L E
Sbjct: 238 LPPPGRSLKFYGVYEPVIC-QRPGPSELPL--SDYPLREAFELLGLENLVQVFTCVLLEM 294
Query: 216 RVLLTASKLSTLTSCVHASCALLYPMRWEHVLIPTLPPHLLDYCCAPMPYLIGVHA 271
++LL + L + LL+P +W+HV +P LP LL + AP+PYL+G+ +
Sbjct: 295 QILLYSQDYQRLMTVAEGITTLLFPFQWQHVYVPILPASLLHFLDAPVPYLMGLQS 350
>gi|148922920 DENN/MADD domain containing 4B [Homo sapiens]
Length = 1496
Score = 62.0 bits (149), Expect = 2e-09
Identities = 105/438 (23%), Positives = 166/438 (37%), Gaps = 83/438 (18%)
Query: 24 SLQEDPPILRQFPPDFRDQEAMQM---VPKFCFPFDVERE-----PPSPAVQHFTFALTD 75
+L + +L ++P + D EA + VP FC P E P TF LT
Sbjct: 208 TLVYEAELLGRYPEE--DNEAFPLPESVPVFCLPMGATIECWPAQTKYPVPVFSTFVLTG 265
Query: 76 LAGNRRFGFC----------RLRAGTQSCLCILSHLPWFEVF----YKLLNTVGDLLAQD 121
AG++ +G RL L +LS + + + L
Sbjct: 266 AAGDKVYGAALQFYEAFPRARLSERQARALGLLSAVERGRALGGRAVRSRRAIAVLSRWP 325
Query: 122 QVTEAEELLQNLFQQSLSGPQASVGLELGSGVT-VSSGQGIPPPTRGN--------SKPL 172
L L++ S+SGP L L + ++ P P R L
Sbjct: 326 AFPAFRAFLTFLYRYSVSGPHR---LPLEAHISHFIHNVPFPSPQRPRILVQMSPYDNLL 382
Query: 173 SCFVAPDSGRLPSIPENRNLTELVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVH 232
C P S LP + +L+ ++ E + L A+L E ++L+ + + LTS
Sbjct: 383 LC--QPVSSPLPL--SGASFLQLLQSLGPELAITLLLAVLTEHKLLVHSLRPDLLTSVCE 438
Query: 233 ASCALLYPMRWEHVLIPTLPPHLLDYCCAPMPYLIGVHASLAERVREKALEDVVVLNVDA 292
A ++++P+ W+ IP P L D AP+P+++G+H+S + A DV+ +++D
Sbjct: 439 ALVSMIFPLHWQCPYIPLCPLVLADVLSAPVPFIVGIHSSYFDLHDPPA--DVICVDLDT 496
Query: 293 NTL----ETTFNDVQALP--PDVVSLLRL-----RLRKVALAPGEGVS------------ 329
NTL E + LP P V L L +L + P E S
Sbjct: 497 NTLFQTEEKKLLSPRTLPRRPYKVLLATLTNLYQQLDQTYTGPEEEASLEFLLTDYEAVC 556
Query: 330 ----RL-------FLKAQALLFGGYR---DALVCSPGQPVTFSEEVFLAQ----KPGAPL 371
RL FL+ A L GYR L +P + + +F Q
Sbjct: 557 GRRARLEREVQGAFLRFMACLLKGYRVFLRPLTQAPSEGARDVDNLFFLQGFLKSRERSS 616
Query: 372 QAFHRRAVHLQLFKQFIE 389
+ + +H Q+F QFIE
Sbjct: 617 HKLYSQLLHTQMFSQFIE 634
>gi|209863002 MAP-kinase activating death domain-containing protein
isoform j [Homo sapiens]
Length = 1541
Score = 58.2 bits (139), Expect = 3e-08
Identities = 70/270 (25%), Positives = 117/270 (43%), Gaps = 36/270 (13%)
Query: 86 RLRAGTQSCLCILSHLPWFEVFYKLLNTVGDLLAQDQVTEA-------------EELLQN 132
R R T + LC+LSH P+F F + L T+ L+ D +E + +
Sbjct: 168 RSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLV--DCCSERLLGKKLGIPRGVQRDTMWR 225
Query: 133 LFQQSLSGPQASVGLE-------------LGSGVTVSSGQGIPPPTRGNS-KPLSCFVAP 178
+F SL + S L L S V VS + + +P F P
Sbjct: 226 IFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALP 285
Query: 179 DSGRLPSIPENRNLTELVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALL 238
D R + +L ++ V + + + +L E +V+L + + L+ V A A++
Sbjct: 286 DPSRFTLVDFPLHLPLELLGV--DACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMI 343
Query: 239 YPMRWEHVLIPTLPPHLL---DYCCAPMPYLIGVHAS-LAERVREKALEDVVVLNVDAN- 293
YP+ + +IP LP + AP PY+IGV AS ++ K +DV ++++D+N
Sbjct: 344 YPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNR 403
Query: 294 TLETTFNDVQALPPDVVSLLRLRLRKVALA 323
+ T +V + P+ SL + K ALA
Sbjct: 404 VIAPTNAEVLPILPEPESLELKKHLKQALA 433
>gi|209862998 MAP-kinase activating death domain-containing protein
isoform i [Homo sapiens]
Length = 1544
Score = 58.2 bits (139), Expect = 3e-08
Identities = 70/270 (25%), Positives = 117/270 (43%), Gaps = 36/270 (13%)
Query: 86 RLRAGTQSCLCILSHLPWFEVFYKLLNTVGDLLAQDQVTEA-------------EELLQN 132
R R T + LC+LSH P+F F + L T+ L+ D +E + +
Sbjct: 168 RSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLV--DCCSERLLGKKLGIPRGVQRDTMWR 225
Query: 133 LFQQSLSGPQASVGLE-------------LGSGVTVSSGQGIPPPTRGNS-KPLSCFVAP 178
+F SL + S L L S V VS + + +P F P
Sbjct: 226 IFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALP 285
Query: 179 DSGRLPSIPENRNLTELVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALL 238
D R + +L ++ V + + + +L E +V+L + + L+ V A A++
Sbjct: 286 DPSRFTLVDFPLHLPLELLGV--DACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMI 343
Query: 239 YPMRWEHVLIPTLPPHLL---DYCCAPMPYLIGVHAS-LAERVREKALEDVVVLNVDAN- 293
YP+ + +IP LP + AP PY+IGV AS ++ K +DV ++++D+N
Sbjct: 344 YPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNR 403
Query: 294 TLETTFNDVQALPPDVVSLLRLRLRKVALA 323
+ T +V + P+ SL + K ALA
Sbjct: 404 VIAPTNAEVLPILPEPESLELKKHLKQALA 433
>gi|209862994 MAP-kinase activating death domain-containing protein
isoform d [Homo sapiens]
Length = 1647
Score = 58.2 bits (139), Expect = 3e-08
Identities = 70/270 (25%), Positives = 117/270 (43%), Gaps = 36/270 (13%)
Query: 86 RLRAGTQSCLCILSHLPWFEVFYKLLNTVGDLLAQDQVTEA-------------EELLQN 132
R R T + LC+LSH P+F F + L T+ L+ D +E + +
Sbjct: 168 RSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLV--DCCSERLLGKKLGIPRGVQRDTMWR 225
Query: 133 LFQQSLSGPQASVGLE-------------LGSGVTVSSGQGIPPPTRGNS-KPLSCFVAP 178
+F SL + S L L S V VS + + +P F P
Sbjct: 226 IFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALP 285
Query: 179 DSGRLPSIPENRNLTELVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALL 238
D R + +L ++ V + + + +L E +V+L + + L+ V A A++
Sbjct: 286 DPSRFTLVDFPLHLPLELLGV--DACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMI 343
Query: 239 YPMRWEHVLIPTLPPHLL---DYCCAPMPYLIGVHAS-LAERVREKALEDVVVLNVDAN- 293
YP+ + +IP LP + AP PY+IGV AS ++ K +DV ++++D+N
Sbjct: 344 YPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNR 403
Query: 294 TLETTFNDVQALPPDVVSLLRLRLRKVALA 323
+ T +V + P+ SL + K ALA
Sbjct: 404 VIAPTNAEVLPILPEPESLELKKHLKQALA 433
>gi|18860873 MAP-kinase activating death domain-containing protein
isoform g [Homo sapiens]
Length = 1581
Score = 58.2 bits (139), Expect = 3e-08
Identities = 70/270 (25%), Positives = 117/270 (43%), Gaps = 36/270 (13%)
Query: 86 RLRAGTQSCLCILSHLPWFEVFYKLLNTVGDLLAQDQVTEA-------------EELLQN 132
R R T + LC+LSH P+F F + L T+ L+ D +E + +
Sbjct: 168 RSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLV--DCCSERLLGKKLGIPRGVQRDTMWR 225
Query: 133 LFQQSLSGPQASVGLE-------------LGSGVTVSSGQGIPPPTRGNS-KPLSCFVAP 178
+F SL + S L L S V VS + + +P F P
Sbjct: 226 IFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALP 285
Query: 179 DSGRLPSIPENRNLTELVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALL 238
D R + +L ++ V + + + +L E +V+L + + L+ V A A++
Sbjct: 286 DPSRFTLVDFPLHLPLELLGV--DACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMI 343
Query: 239 YPMRWEHVLIPTLPPHLL---DYCCAPMPYLIGVHAS-LAERVREKALEDVVVLNVDAN- 293
YP+ + +IP LP + AP PY+IGV AS ++ K +DV ++++D+N
Sbjct: 344 YPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNR 403
Query: 294 TLETTFNDVQALPPDVVSLLRLRLRKVALA 323
+ T +V + P+ SL + K ALA
Sbjct: 404 VIAPTNAEVLPILPEPESLELKKHLKQALA 433
>gi|209862987 MAP-kinase activating death domain-containing protein
isoform f [Homo sapiens]
Length = 1479
Score = 58.2 bits (139), Expect = 3e-08
Identities = 70/270 (25%), Positives = 117/270 (43%), Gaps = 36/270 (13%)
Query: 86 RLRAGTQSCLCILSHLPWFEVFYKLLNTVGDLLAQDQVTEA-------------EELLQN 132
R R T + LC+LSH P+F F + L T+ L+ D +E + +
Sbjct: 168 RSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLV--DCCSERLLGKKLGIPRGVQRDTMWR 225
Query: 133 LFQQSLSGPQASVGLE-------------LGSGVTVSSGQGIPPPTRGNS-KPLSCFVAP 178
+F SL + S L L S V VS + + +P F P
Sbjct: 226 IFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALP 285
Query: 179 DSGRLPSIPENRNLTELVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALL 238
D R + +L ++ V + + + +L E +V+L + + L+ V A A++
Sbjct: 286 DPSRFTLVDFPLHLPLELLGV--DACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMI 343
Query: 239 YPMRWEHVLIPTLPPHLL---DYCCAPMPYLIGVHAS-LAERVREKALEDVVVLNVDAN- 293
YP+ + +IP LP + AP PY+IGV AS ++ K +DV ++++D+N
Sbjct: 344 YPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNR 403
Query: 294 TLETTFNDVQALPPDVVSLLRLRLRKVALA 323
+ T +V + P+ SL + K ALA
Sbjct: 404 VIAPTNAEVLPILPEPESLELKKHLKQALA 433
>gi|209862983 MAP-kinase activating death domain-containing protein
isoform e [Homo sapiens]
Length = 1608
Score = 58.2 bits (139), Expect = 3e-08
Identities = 70/270 (25%), Positives = 117/270 (43%), Gaps = 36/270 (13%)
Query: 86 RLRAGTQSCLCILSHLPWFEVFYKLLNTVGDLLAQDQVTEA-------------EELLQN 132
R R T + LC+LSH P+F F + L T+ L+ D +E + +
Sbjct: 168 RSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLV--DCCSERLLGKKLGIPRGVQRDTMWR 225
Query: 133 LFQQSLSGPQASVGLE-------------LGSGVTVSSGQGIPPPTRGNS-KPLSCFVAP 178
+F SL + S L L S V VS + + +P F P
Sbjct: 226 IFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALP 285
Query: 179 DSGRLPSIPENRNLTELVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALL 238
D R + +L ++ V + + + +L E +V+L + + L+ V A A++
Sbjct: 286 DPSRFTLVDFPLHLPLELLGV--DACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMI 343
Query: 239 YPMRWEHVLIPTLPPHLL---DYCCAPMPYLIGVHAS-LAERVREKALEDVVVLNVDAN- 293
YP+ + +IP LP + AP PY+IGV AS ++ K +DV ++++D+N
Sbjct: 344 YPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNR 403
Query: 294 TLETTFNDVQALPPDVVSLLRLRLRKVALA 323
+ T +V + P+ SL + K ALA
Sbjct: 404 VIAPTNAEVLPILPEPESLELKKHLKQALA 433
>gi|209862979 MAP-kinase activating death domain-containing protein
isoform c [Homo sapiens]
Length = 1545
Score = 58.2 bits (139), Expect = 3e-08
Identities = 70/270 (25%), Positives = 117/270 (43%), Gaps = 36/270 (13%)
Query: 86 RLRAGTQSCLCILSHLPWFEVFYKLLNTVGDLLAQDQVTEA-------------EELLQN 132
R R T + LC+LSH P+F F + L T+ L+ D +E + +
Sbjct: 168 RSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLV--DCCSERLLGKKLGIPRGVQRDTMWR 225
Query: 133 LFQQSLSGPQASVGLE-------------LGSGVTVSSGQGIPPPTRGNS-KPLSCFVAP 178
+F SL + S L L S V VS + + +P F P
Sbjct: 226 IFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALP 285
Query: 179 DSGRLPSIPENRNLTELVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALL 238
D R + +L ++ V + + + +L E +V+L + + L+ V A A++
Sbjct: 286 DPSRFTLVDFPLHLPLELLGV--DACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMI 343
Query: 239 YPMRWEHVLIPTLPPHLL---DYCCAPMPYLIGVHAS-LAERVREKALEDVVVLNVDAN- 293
YP+ + +IP LP + AP PY+IGV AS ++ K +DV ++++D+N
Sbjct: 344 YPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNR 403
Query: 294 TLETTFNDVQALPPDVVSLLRLRLRKVALA 323
+ T +V + P+ SL + K ALA
Sbjct: 404 VIAPTNAEVLPILPEPESLELKKHLKQALA 433
>gi|209862975 MAP-kinase activating death domain-containing protein
isoform b [Homo sapiens]
Length = 1565
Score = 58.2 bits (139), Expect = 3e-08
Identities = 70/270 (25%), Positives = 117/270 (43%), Gaps = 36/270 (13%)
Query: 86 RLRAGTQSCLCILSHLPWFEVFYKLLNTVGDLLAQDQVTEA-------------EELLQN 132
R R T + LC+LSH P+F F + L T+ L+ D +E + +
Sbjct: 168 RSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLV--DCCSERLLGKKLGIPRGVQRDTMWR 225
Query: 133 LFQQSLSGPQASVGLE-------------LGSGVTVSSGQGIPPPTRGNS-KPLSCFVAP 178
+F SL + S L L S V VS + + +P F P
Sbjct: 226 IFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALP 285
Query: 179 DSGRLPSIPENRNLTELVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALL 238
D R + +L ++ V + + + +L E +V+L + + L+ V A A++
Sbjct: 286 DPSRFTLVDFPLHLPLELLGV--DACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMI 343
Query: 239 YPMRWEHVLIPTLPPHLL---DYCCAPMPYLIGVHAS-LAERVREKALEDVVVLNVDAN- 293
YP+ + +IP LP + AP PY+IGV AS ++ K +DV ++++D+N
Sbjct: 344 YPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNR 403
Query: 294 TLETTFNDVQALPPDVVSLLRLRLRKVALA 323
+ T +V + P+ SL + K ALA
Sbjct: 404 VIAPTNAEVLPILPEPESLELKKHLKQALA 433
>gi|209862971 MAP-kinase activating death domain-containing protein
isoform a [Homo sapiens]
Length = 1588
Score = 58.2 bits (139), Expect = 3e-08
Identities = 70/270 (25%), Positives = 117/270 (43%), Gaps = 36/270 (13%)
Query: 86 RLRAGTQSCLCILSHLPWFEVFYKLLNTVGDLLAQDQVTEA-------------EELLQN 132
R R T + LC+LSH P+F F + L T+ L+ D +E + +
Sbjct: 168 RSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLV--DCCSERLLGKKLGIPRGVQRDTMWR 225
Query: 133 LFQQSLSGPQASVGLE-------------LGSGVTVSSGQGIPPPTRGNS-KPLSCFVAP 178
+F SL + S L L S V VS + + +P F P
Sbjct: 226 IFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALP 285
Query: 179 DSGRLPSIPENRNLTELVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALL 238
D R + +L ++ V + + + +L E +V+L + + L+ V A A++
Sbjct: 286 DPSRFTLVDFPLHLPLELLGV--DACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMI 343
Query: 239 YPMRWEHVLIPTLPPHLL---DYCCAPMPYLIGVHAS-LAERVREKALEDVVVLNVDAN- 293
YP+ + +IP LP + AP PY+IGV AS ++ K +DV ++++D+N
Sbjct: 344 YPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNR 403
Query: 294 TLETTFNDVQALPPDVVSLLRLRLRKVALA 323
+ T +V + P+ SL + K ALA
Sbjct: 404 VIAPTNAEVLPILPEPESLELKKHLKQALA 433
>gi|209571517 MAP-kinase activating death domain-containing protein
isoform h [Homo sapiens]
Length = 1587
Score = 58.2 bits (139), Expect = 3e-08
Identities = 70/270 (25%), Positives = 117/270 (43%), Gaps = 36/270 (13%)
Query: 86 RLRAGTQSCLCILSHLPWFEVFYKLLNTVGDLLAQDQVTEA-------------EELLQN 132
R R T + LC+LSH P+F F + L T+ L+ D +E + +
Sbjct: 168 RSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLV--DCCSERLLGKKLGIPRGVQRDTMWR 225
Query: 133 LFQQSLSGPQASVGLE-------------LGSGVTVSSGQGIPPPTRGNS-KPLSCFVAP 178
+F SL + S L L S V VS + + +P F P
Sbjct: 226 IFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALP 285
Query: 179 DSGRLPSIPENRNLTELVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALL 238
D R + +L ++ V + + + +L E +V+L + + L+ V A A++
Sbjct: 286 DPSRFTLVDFPLHLPLELLGV--DACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMI 343
Query: 239 YPMRWEHVLIPTLPPHLL---DYCCAPMPYLIGVHAS-LAERVREKALEDVVVLNVDAN- 293
YP+ + +IP LP + AP PY+IGV AS ++ K +DV ++++D+N
Sbjct: 344 YPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNR 403
Query: 294 TLETTFNDVQALPPDVVSLLRLRLRKVALA 323
+ T +V + P+ SL + K ALA
Sbjct: 404 VIAPTNAEVLPILPEPESLELKKHLKQALA 433
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.132 0.398
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,199,745
Number of Sequences: 37866
Number of extensions: 2073602
Number of successful extensions: 12901
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 77
Number of HSP's successfully gapped in prelim test: 695
Number of HSP's that attempted gapping in prelim test: 10109
Number of HSP's gapped (non-prelim): 2792
length of query: 801
length of database: 18,247,518
effective HSP length: 110
effective length of query: 691
effective length of database: 14,082,258
effective search space: 9730840278
effective search space used: 9730840278
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.