Search of human proteins with 10834998

Search of human proteins with 10834998

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide
1 [Homo sapiens]
         (493 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide ...  1017   0.0  
gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 1...   603   e-173
gi|13699816 cytochrome P450 family 2 subfamily C polypeptide 18 ...   597   e-171
gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide ...   591   e-169
gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide ...   580   e-166
gi|19743565 cytochrome P450, family 2, subfamily F, polypeptide ...   492   e-139
gi|13699809 cytochrome P450, family 2, subfamily A, polypeptide ...   475   e-134
gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide...   474   e-134
gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6...   464   e-131
gi|193083148 cytochrome P450 family 2 subfamily C polypeptide 18...   459   e-129
gi|15147330 cytochrome P450, family 2, subfamily A, polypeptide ...   458   e-129
gi|15147328 cytochrome P450, family 2, subfamily A, polypeptide ...   394   e-109
gi|13449277 cytochrome P450, family 2, subfamily S, polypeptide ...   381   e-106
gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide ...   363   e-100
gi|40805836 cytochrome P450, family 2, subfamily D, polypeptide ...   340   2e-93
gi|64368472 cytochrome P450, family 2, subfamily W, polypeptide ...   326   3e-89
gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide ...   301   9e-82
gi|68509921 cytochrome P450, family 2, subfamily D, polypeptide ...   293   3e-79
gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide ...   287   2e-77
gi|4503199 cytochrome P450, family 1, subfamily A, polypeptide 1...   226   4e-59
gi|73915100 cytochrome P450, family 1, subfamily A, polypeptide ...   213   4e-55
gi|189491763 cytochrome P450, family 1, subfamily B, polypeptide...   210   2e-54
gi|4503195 cytochrome P450, family 17 [Homo sapiens]                  186   5e-47
gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide...   179   4e-45
gi|190570174 cytochrome P450, family 21, subfamily A, polypeptid...   163   3e-40
gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide...   118   1e-26
gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1 ...   113   3e-25
gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide ...   111   1e-24
gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide ...   109   7e-24
gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5...   108   1e-23

>gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide 1
           [Homo sapiens]
          Length = 493

 Score = 1017 bits (2630), Expect = 0.0
 Identities = 493/493 (100%), Positives = 493/493 (100%)

Query: 1   MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRL 60
           MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRL
Sbjct: 1   MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRL 60

Query: 61  AQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGP 120
           AQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGP
Sbjct: 61  AQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGP 120

Query: 121 TWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVI 180
           TWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVI
Sbjct: 121 TWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVI 180

Query: 181 ADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVA 240
           ADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVA
Sbjct: 181 ADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVA 240

Query: 241 EVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAG 300
           EVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAG
Sbjct: 241 EVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAG 300

Query: 301 TETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRF 360
           TETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRF
Sbjct: 301 TETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRF 360

Query: 361 ITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGK 420
           ITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGK
Sbjct: 361 ITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGK 420

Query: 421 FKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGC 480
           FKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGC
Sbjct: 421 FKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGC 480

Query: 481 IPPRYKLCVIPRS 493
           IPPRYKLCVIPRS
Sbjct: 481 IPPRYKLCVIPRS 493


>gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 19
           [Homo sapiens]
          Length = 490

 Score =  603 bits (1556), Expect = e-173
 Identities = 280/485 (57%), Positives = 370/485 (76%), Gaps = 1/485 (0%)

Query: 8   VALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPV 67
           V L++  + LLL+S+WRQ      LPPGP PLP+IGN+ Q+++K++ KS T L++ +GPV
Sbjct: 5   VVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPV 64

Query: 68  FTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLP-AFHAHRDRGIIFNNGPTWKDIR 126
           FTLY G +RMVV+HGY+ VKEAL+D  +EFSGRG  P A  A+R  GI+F+NG  WK+IR
Sbjct: 65  FTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIR 124

Query: 127 RFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFR 186
           RFSL TLRN+GMGK+  E R+Q EA  L+E LRKT+  P DPTF++GCAPCNVI  I+F+
Sbjct: 125 RFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQ 184

Query: 187 KHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYV 246
           K FDY D++FL LM   NEN  ++STPW+Q+ NNFP+ + Y PG+H K++KN+A ++  +
Sbjct: 185 KRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDI 244

Query: 247 SERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTST 306
            E+VKEH +S+D N PRD  DC L++MEKEK + +  +T++ + +T ADL  AGTETTST
Sbjct: 245 LEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTST 304

Query: 307 TLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPS 366
           TLRY LL+L+K+PE+  K+ EEI+RVIG +R P ++DR  MPY DAVVHE+QR+I L+P+
Sbjct: 305 TLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPT 364

Query: 367 NLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDY 426
           +LPH  T D  FR YLIPKGT ++ +L SVL+DN+EFP+PE F P HFL+E G FK S+Y
Sbjct: 365 SLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNY 424

Query: 427 FKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYK 486
           F PFS GKR+C GEGLARMELFL L  ILQ+FNLK L+DPKD+D +P+  GF  +PP Y+
Sbjct: 425 FMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQ 484

Query: 487 LCVIP 491
           LC IP
Sbjct: 485 LCFIP 489


>gi|13699816 cytochrome P450 family 2 subfamily C polypeptide 18
           isoform 1 [Homo sapiens]
          Length = 490

 Score =  597 bits (1539), Expect = e-171
 Identities = 279/485 (57%), Positives = 366/485 (75%), Gaps = 1/485 (0%)

Query: 8   VALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPV 67
           VAL++  + L L+S+WRQ      LP GP PLPIIGN+ QL++K++ KS T  ++ +GPV
Sbjct: 5   VALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGPV 64

Query: 68  FTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLP-AFHAHRDRGIIFNNGPTWKDIR 126
           FT+Y G + +VV+HGY+AVKEAL+D+ +EFSGRG  P A   ++  GI+F+NG  WK+IR
Sbjct: 65  FTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIR 124

Query: 127 RFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFR 186
           RF L TLRN+GMGK+  E R+Q EA  L+E LRKT   P DPTF++GCAPCNVI  ++F 
Sbjct: 125 RFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFH 184

Query: 187 KHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYV 246
             FDY D++FL LM  FNEN  +LS+PW+Q+ NNFP+ + YLPGSH K+ +N A +K YV
Sbjct: 185 DRFDYKDQRFLNLMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYIKSYV 244

Query: 247 SERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTST 306
            ER+KEH +SLD N  RD  DC L++ME+EKH+ +  +T++ +  TV D+F AGTETTST
Sbjct: 245 LERIKEHQESLDMNSARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETTST 304

Query: 307 TLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPS 366
           TLRYGLL+L+KYPE+  K+ EEI+ V+G +R P ++DR  MPY DAVVHEIQR+I L+P+
Sbjct: 305 TLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPT 364

Query: 367 NLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDY 426
           NLPH  T D  F+ YLIPKGT ++ +L SVL++++EFP+PE F P HFL+++G FK SDY
Sbjct: 365 NLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDY 424

Query: 427 FKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYK 486
           F PFS GKR+C GEGLARMELFL L  ILQ+FNLK  VDPKDID++PI   FG +PP Y+
Sbjct: 425 FMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVPPLYQ 484

Query: 487 LCVIP 491
           LC IP
Sbjct: 485 LCFIP 489


>gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide 9
           [Homo sapiens]
          Length = 490

 Score =  591 bits (1524), Expect = e-169
 Identities = 280/485 (57%), Positives = 364/485 (75%), Gaps = 1/485 (0%)

Query: 8   VALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPV 67
           V L++  + LLL+S+WRQ      LPPGP PLP+IGN+ Q+ +K+I KS T L++ +GPV
Sbjct: 5   VVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPV 64

Query: 68  FTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLP-AFHAHRDRGIIFNNGPTWKDIR 126
           FTLY G + +VV+HGY+AVKEAL+D  +EFSGRG  P A  A+R  GI+F+NG  WK+IR
Sbjct: 65  FTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIR 124

Query: 127 RFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFR 186
           RFSL TLRN+GMGK+  E R+Q EA  L+E LRKT+  P DPTF++GCAPCNVI  I+F 
Sbjct: 125 RFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFH 184

Query: 187 KHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYV 246
           K FDY D++FL LM   NEN  +LS+PW+Q+ NNF   + Y PG+H K++KNVA +K Y+
Sbjct: 185 KRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYI 244

Query: 247 SERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTST 306
            E+VKEH +S+D N P+D  DC L++MEKEKH+    +T++ +  T  DLF AGTETTST
Sbjct: 245 LEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTST 304

Query: 307 TLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPS 366
           TLRY LL+L+K+PE+  K+ EEI+RVIG +R P ++DR  MPY DAVVHE+QR+I L+P+
Sbjct: 305 TLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPT 364

Query: 367 NLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDY 426
           +LPH  T D  FR YLIPKGT ++ +L SVL+DN+EFP+PE F P HFL+E G FK S Y
Sbjct: 365 SLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKY 424

Query: 427 FKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYK 486
           F PFS GKR+C GE LA MELFL L +ILQ+FNLK LVDPK++D +P+  GF  +PP Y+
Sbjct: 425 FMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQ 484

Query: 487 LCVIP 491
           LC IP
Sbjct: 485 LCFIP 489


>gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide 8
           [Homo sapiens]
          Length = 490

 Score =  580 bits (1496), Expect = e-166
 Identities = 277/485 (57%), Positives = 360/485 (74%), Gaps = 1/485 (0%)

Query: 8   VALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPV 67
           V L++  +F+LL S+WRQ      LPPGP PLPIIGN+ Q+++K+I KSFT  ++ +GPV
Sbjct: 5   VVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPV 64

Query: 68  FTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLP-AFHAHRDRGIIFNNGPTWKDIR 126
           FT+Y G   +VV HGY+AVKEAL+D  +EFSGRG+ P +    +  GII +NG  WK+IR
Sbjct: 65  FTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIR 124

Query: 127 RFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFR 186
           RFSLTTLRN+GMGK+  E R+Q EAH L+E LRKT+  P DPTF++GCAPCNVI  ++F+
Sbjct: 125 RFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQ 184

Query: 187 KHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYV 246
           K FDY D+ FL LM  FNENF +L++PW+Q+ NNFP  +   PG+H KV+KNVA  + Y+
Sbjct: 185 KRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYI 244

Query: 247 SERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTST 306
            E+VKEH  SLD N PRD  DC L++ME+EK + +  + ++ +  TVADLF AGTETTST
Sbjct: 245 REKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTST 304

Query: 307 TLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPS 366
           TLRYGLL+L+K+PE+  K+ EEID VIG  R P ++DR  MPY DAVVHEIQR+  LVP+
Sbjct: 305 TLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPT 364

Query: 367 NLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDY 426
            +PH  T DT FR YLIPKGT ++  L SVL+D++EFP+P  F P HFL++NG FK SDY
Sbjct: 365 GVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDY 424

Query: 427 FKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYK 486
           F PFS GKR+CAGEGLARMELFL L  ILQ+FNLK + D K+++ + +  G   +PP Y+
Sbjct: 425 FMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQ 484

Query: 487 LCVIP 491
           +C IP
Sbjct: 485 ICFIP 489


>gi|19743565 cytochrome P450, family 2, subfamily F, polypeptide 1
           [Homo sapiens]
          Length = 491

 Score =  492 bits (1267), Expect = e-139
 Identities = 236/493 (47%), Positives = 340/493 (68%), Gaps = 3/493 (0%)

Query: 1   MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRL 60
           M ++   + LL+ A   LL+++         LPPGP PL I+GNL  L  +++  S T+L
Sbjct: 1   MDSISTAILLLLLALVCLLLTL--SSRDKGKLPPGPRPLSILGNLLLLCSQDMLTSLTKL 58

Query: 61  AQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAF-HAHRDRGIIFNNG 119
           ++ +G ++T+++G +R+VV+ GY+AVKEAL+D  +EFSGRGD PAF +  +  GI F++G
Sbjct: 59  SKEYGSMYTVHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYPAFFNFTKGNGIAFSSG 118

Query: 120 PTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNV 179
             WK +R+FS+  LRN+GMGK+  E RI  E  FLL  LRKT+G+PFDPTF++  +  N+
Sbjct: 119 DRWKVLRQFSIQILRNFGMGKRSIEERILEEGSFLLAELRKTEGEPFDPTFVLSRSVSNI 178

Query: 180 IADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNV 239
           I  +LF   FDY+DE+ L ++ L N+NF ++S+PW +LY+ FPS L ++PG H+++ +N 
Sbjct: 179 ICSVLFGSRFDYDDERLLTIIRLINDNFQIMSSPWGELYDIFPSLLDWVPGPHQRIFQNF 238

Query: 240 AEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFA 299
             +++ ++  V +H  SLDP  PRD   C L +M +EK      + MD + +T  +L F 
Sbjct: 239 KCLRDLIAHSVHDHQASLDPRSPRDFIQCFLTKMAEEKEDPLSHFHMDTLLMTTHNLLFG 298

Query: 300 GTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQR 359
           GT+T STTL +  L LMKYP+++ ++ EEID V+G +R+PA+KDR  MPY DAV+HE+QR
Sbjct: 299 GTKTVSTTLHHAFLALMKYPKVQARVQEEIDLVVGRARLPALKDRAAMPYTDAVIHEVQR 358

Query: 360 FITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENG 419
           F  ++P NLPH  TRDT FRG+LIPKGT V+  L++V YD  +F  P++F PEHFL+ N 
Sbjct: 359 FADIIPMNLPHRVTRDTAFRGFLIPKGTDVITLLNTVHYDPSQFLTPQEFNPEHFLDANQ 418

Query: 420 KFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFG 479
            FK S  F PFS G+R+C GE LARMELFL L AILQ F+L+PL  P+DIDL+P+  G G
Sbjct: 419 SFKKSPAFMPFSAGRRLCLGESLARMELFLYLTAILQSFSLQPLGAPEDIDLTPLSSGLG 478

Query: 480 CIPPRYKLCVIPR 492
            +P  ++LC+ PR
Sbjct: 479 NLPRPFQLCLRPR 491


>gi|13699809 cytochrome P450, family 2, subfamily A, polypeptide 13
           [Homo sapiens]
          Length = 494

 Score =  475 bits (1222), Expect = e-134
 Identities = 232/486 (47%), Positives = 325/486 (66%), Gaps = 1/486 (0%)

Query: 8   VALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPV 67
           V LL     ++L+S+WRQ  S   LPPGP PLP IGN  QL  + +  S  ++++R+GPV
Sbjct: 9   VTLLACLTVMVLMSVWRQRKSRGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPV 68

Query: 68  FTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFH-AHRDRGIIFNNGPTWKDIR 126
           FT+++G +R+VV+ G+ AVKEAL+D  +EFSGRG+   F    +  G+ F+NG   K +R
Sbjct: 69  FTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSNGERAKQLR 128

Query: 127 RFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFR 186
           RFS+ TLR +G+GK+G E RIQ EA FL++ALR T G   DPTF +     NVI+ I+F 
Sbjct: 129 RFSIATLRGFGVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSNVISSIVFG 188

Query: 187 KHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYV 246
             FDY D++FL L+ +   +F   +T   QLY  F S + +LPG  ++  K +  +++++
Sbjct: 189 DRFDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAFKELQGLEDFI 248

Query: 247 SERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTST 306
           +++V+ + ++LDPN PRD  D  L+ M++E+ +    + +  + +T  +LFFAGTET ST
Sbjct: 249 AKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVST 308

Query: 307 TLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPS 366
           TLRYG L+LMK+PE+E K+HEEIDRVIG +R P  +DR +MPY +AV+HEIQRF  ++P 
Sbjct: 309 TLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDMLPM 368

Query: 367 NLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDY 426
            L H   +DT FR + +PKGT V P L SVL D + F +P  F P+HFL++ G+FK SD 
Sbjct: 369 GLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKKGQFKKSDA 428

Query: 427 FKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYK 486
           F PFS GKR C GEGLARMELFL    I+Q+F  K    PKDID+SP H+GF  IP  Y 
Sbjct: 429 FVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSPKHVGFATIPRNYT 488

Query: 487 LCVIPR 492
           +  +PR
Sbjct: 489 MSFLPR 494


>gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide 6
           [Homo sapiens]
          Length = 494

 Score =  474 bits (1221), Expect = e-134
 Identities = 232/486 (47%), Positives = 328/486 (67%), Gaps = 1/486 (0%)

Query: 8   VALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPV 67
           VALLV    ++L+S+W+Q  S   LPPGP PLP IGN  QL  + +  S  ++++R+GPV
Sbjct: 9   VALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPV 68

Query: 68  FTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFH-AHRDRGIIFNNGPTWKDIR 126
           FT+++G +R+VV+ G+ AV+EAL+D  +EFSGRG+   F    +  G++F+NG   K +R
Sbjct: 69  FTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLR 128

Query: 127 RFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFR 186
           RFS+ TLR++G+GK+G E RIQ EA FL++ALR T G   DPTF +     NVI+ I+F 
Sbjct: 129 RFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFG 188

Query: 187 KHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYV 246
             FDY D++FL L+ +    F   ST   QLY  F S + +LPG  ++  + +  +++++
Sbjct: 189 DRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFI 248

Query: 247 SERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTST 306
           +++V+ + ++LDPN PRD  D  L+ M++E+ +    + +  + +T  +LF  GTET ST
Sbjct: 249 AKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVST 308

Query: 307 TLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPS 366
           TLRYG L+LMK+PE+E K+HEEIDRVIG +R P  +DR +MPYM+AV+HEIQRF  ++P 
Sbjct: 309 TLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPM 368

Query: 367 NLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDY 426
           +L     +DT FR + +PKGT V P L SVL D   F +P+ F P+HFLNE G+FK SD 
Sbjct: 369 SLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDA 428

Query: 427 FKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYK 486
           F PFS GKR C GEGLARMELFL    ++Q+F LK    PKDID+SP H+GF  IP  Y 
Sbjct: 429 FVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYT 488

Query: 487 LCVIPR 492
           +  +PR
Sbjct: 489 MSFLPR 494


>gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6
           [Homo sapiens]
          Length = 491

 Score =  464 bits (1195), Expect = e-131
 Identities = 224/477 (46%), Positives = 324/477 (67%), Gaps = 1/477 (0%)

Query: 17  LLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQR 76
           LLL+ + R  ++   LPPGP PLP++GNL Q++ + + KSF R  +++G VFT+++G + 
Sbjct: 15  LLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRP 74

Query: 77  MVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAH-RDRGIIFNNGPTWKDIRRFSLTTLRN 135
           +V++ G +A++EAL+D  + FSGRG +       R  G+IF NG  WK +RRFS+TT+R+
Sbjct: 75  VVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRD 134

Query: 136 YGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEK 195
           +GMGK+  E RIQ EA  L+E LRK++G   DPTFL      N+I  I+F K F Y D++
Sbjct: 135 FGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQE 194

Query: 196 FLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQ 255
           FL+++ LF + F L+S+ + QL+  F  FL Y PG+HR+V KN+ E+  Y+   V++H +
Sbjct: 195 FLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRE 254

Query: 256 SLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLIL 315
           +LDP+ P+DL D  L+ MEKEK +A   ++   + +    LFFAGTETTSTTLRYG L++
Sbjct: 255 TLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLM 314

Query: 316 MKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRD 375
           +KYP + E+++ EI++VIGP R P + DR +MPY +AV++EIQRF  L+P  +PH  T+ 
Sbjct: 315 LKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQH 374

Query: 376 TIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKR 435
           T FRGY+IPK T V   L + L+D   F  P+ F P+HFL+ NG  K ++ F PFS GKR
Sbjct: 375 TSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKR 434

Query: 436 VCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYKLCVIPR 492
           +C GEG+AR ELFL    ILQ+F++   V P+DIDL+P   G G IPP Y++  +PR
Sbjct: 435 ICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR 491


>gi|193083148 cytochrome P450 family 2 subfamily C polypeptide 18
           isoform 2 [Homo sapiens]
          Length = 431

 Score =  459 bits (1182), Expect = e-129
 Identities = 236/485 (48%), Positives = 311/485 (64%), Gaps = 60/485 (12%)

Query: 8   VALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPV 67
           VAL++  + L L+S+WRQ      LP GP PLPIIGN+ QL++K++ KS T  ++ +GPV
Sbjct: 5   VALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGPV 64

Query: 68  FTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLP-AFHAHRDRGIIFNNGPTWKDIR 126
           FT+Y G + +VV+HGY+AVKEAL+D+ +EFSGRG  P A   ++  GI+F+NG  WK+IR
Sbjct: 65  FTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIR 124

Query: 127 RFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFR 186
           RF L TLRN+GMGK+  E R+Q EA  L+E LRKT   P DPTF++GCAPCNVI  ++  
Sbjct: 125 RFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVI-- 182

Query: 187 KHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYV 246
                           F++ F      +L L   F   L  L                  
Sbjct: 183 ----------------FHDRFDYKDQRFLNLMEKFNENLRILSSP--------------- 211

Query: 247 SERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTST 306
                                       +EKH+ +  +T++ +  TV D+F AGTETTST
Sbjct: 212 --------------------------WIQEKHNQQSEFTVESLIATVTDMFGAGTETTST 245

Query: 307 TLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPS 366
           TLRYGLL+L+KYPE+  K+ EEI+ V+G +R P ++DR  MPY DAVVHEIQR+I L+P+
Sbjct: 246 TLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPT 305

Query: 367 NLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDY 426
           NLPH  T D  F+ YLIPKGT ++ +L SVL++++EFP+PE F P HFL+++G FK SDY
Sbjct: 306 NLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDY 365

Query: 427 FKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYK 486
           F PFS GKR+C GEGLARMELFL L  ILQ+FNLK  VDPKDID++PI   FG +PP Y+
Sbjct: 366 FMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVPPLYQ 425

Query: 487 LCVIP 491
           LC IP
Sbjct: 426 LCFIP 430


>gi|15147330 cytochrome P450, family 2, subfamily A, polypeptide 7
           isoform 1 [Homo sapiens]
          Length = 494

 Score =  458 bits (1179), Expect = e-129
 Identities = 225/486 (46%), Positives = 324/486 (66%), Gaps = 1/486 (0%)

Query: 8   VALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPV 67
           VALL     ++L+S+W+Q  S   LPPGP PLP IGN  QL  ++I  S  + ++ +GPV
Sbjct: 9   VALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMKFSECYGPV 68

Query: 68  FTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFH-AHRDRGIIFNNGPTWKDIR 126
           FT+++G +R+VV+ G+ AV+EAL+D  +EFSGRG+   F    +  G+ F+NG   K + 
Sbjct: 69  FTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVAFSNGERAKQLL 128

Query: 127 RFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFR 186
           RF++ TLR++G+GK+G E RIQ E+ FL+EA+R T G   DPTF +     NVI+ I+F 
Sbjct: 129 RFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIVFG 188

Query: 187 KHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYV 246
             FDY D++FL L+ +    F   ST   QLY  F S + +LPG  ++  K +  +++++
Sbjct: 189 DRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKLLQGLEDFI 248

Query: 247 SERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTST 306
           +++V+ + ++LDPN P+D  D  L+ M++E+ +    + +  + ++  +LF AGTET ST
Sbjct: 249 AKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVST 308

Query: 307 TLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPS 366
           TLRYG L+LMK+PE+E K+HEEIDRVIG +R P  +DR +MPYM+AV+HEIQRF  ++P 
Sbjct: 309 TLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVIPM 368

Query: 367 NLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDY 426
           +L     +DT FR + +PKGT V P L SVL D   F +P+ F P+HFL++ G+FK SD 
Sbjct: 369 SLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKSDA 428

Query: 427 FKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYK 486
           F PFS GKR C GEGLARMELFL    ++Q+F LK    PKDID+SP H+ F  IP  Y 
Sbjct: 429 FVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVFATIPRNYT 488

Query: 487 LCVIPR 492
           +  +PR
Sbjct: 489 MSFLPR 494


>gi|15147328 cytochrome P450, family 2, subfamily A, polypeptide 7
           isoform 2 [Homo sapiens]
          Length = 443

 Score =  394 bits (1011), Expect = e-109
 Identities = 203/485 (41%), Positives = 289/485 (59%), Gaps = 50/485 (10%)

Query: 8   VALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPV 67
           VALL     ++L+S+W+Q  S   LPPGP PLP IGN  QL  ++I  S  +++Q     
Sbjct: 9   VALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMKVSQ----- 63

Query: 68  FTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGPTWKDIRR 127
                                                        G+ F+NG   K + R
Sbjct: 64  ---------------------------------------------GVAFSNGERAKQLLR 78

Query: 128 FSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRK 187
           F++ TLR++G+GK+G E RIQ E+ FL+EA+R T G   DPTF +     NVI+ I+F  
Sbjct: 79  FAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIVFGD 138

Query: 188 HFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVS 247
            FDY D++FL L+ +    F   ST   QLY  F S + +LPG  ++  K +  ++++++
Sbjct: 139 RFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKLLQGLEDFIA 198

Query: 248 ERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTT 307
           ++V+ + ++LDPN P+D  D  L+ M++E+ +    + +  + ++  +LF AGTET STT
Sbjct: 199 KKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVSTT 258

Query: 308 LRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSN 367
           LRYG L+LMK+PE+E K+HEEIDRVIG +R P  +DR +MPYM+AV+HEIQRF  ++P +
Sbjct: 259 LRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVIPMS 318

Query: 368 LPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYF 427
           L     +DT FR + +PKGT V P L SVL D   F +P+ F P+HFL++ G+FK SD F
Sbjct: 319 LARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKSDAF 378

Query: 428 KPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYKL 487
            PFS GKR C GEGLARMELFL    ++Q+F LK    PKDID+SP H+ F  IP  Y +
Sbjct: 379 VPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVFATIPRNYTM 438

Query: 488 CVIPR 492
             +PR
Sbjct: 439 SFLPR 443


>gi|13449277 cytochrome P450, family 2, subfamily S, polypeptide 1
           [Homo sapiens]
          Length = 504

 Score =  381 bits (978), Expect = e-106
 Identities = 203/494 (41%), Positives = 297/494 (60%), Gaps = 3/494 (0%)

Query: 1   MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRL 60
           M A G    LL  A  LLL        +  +LPPGP PLP++GNL QL    +     RL
Sbjct: 1   MEATGTWALLLALALLLLLTLALSGTRARGHLPPGPTPLPLLGNLLQLRPGALYSGLMRL 60

Query: 61  AQRFGPVFTLYVGSQR-MVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRD-RGIIFNN 118
           ++++GPVFT+Y+G  R +VV+ G +AV+EAL    +EFSGRG +       D  G+ F+N
Sbjct: 61  SKKYGPVFTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGHGVFFSN 120

Query: 119 GPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCN 178
           G  W+ +R+F++  LR+ GMGK+  E  IQ EA  L+E  + T+G+PFDP+ L+  A  N
Sbjct: 121 GERWRQLRKFTMLALRDLGMGKREGEELIQAEARCLVETFQGTEGRPFDPSLLLAQATSN 180

Query: 179 VIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKN 238
           V+  +LF   F Y D++F  ++         +S+   Q Y  F  FL  LPG H++++ +
Sbjct: 181 VVCSLLFGLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRPLPGPHKQLLHH 240

Query: 239 VAEVKEYVSERVKEHHQSLDPNCP-RDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLF 297
           V+ +  +   +V++H  +LD + P RDL D  L++M +E+ +    +T   + +TV  L 
Sbjct: 241 VSTLAAFTVRQVQQHQGNLDASGPARDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVIYLL 300

Query: 298 FAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEI 357
           FAGT T STT+ Y LL+LMKYP +++ + EE++R +G  + P++ DR  +PY DAV+HE 
Sbjct: 301 FAGTMTVSTTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPSLGDRTRLPYTDAVLHEA 360

Query: 358 QRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNE 417
           QR + LVP  +P    R T FRGY +P+GT V P L S+L+D   F  PE+F P+ FL+ 
Sbjct: 361 QRLLALVPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFLDA 420

Query: 418 NGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIG 477
           +G+F+  + F PFS GKRVC GEGLA+ ELFL    ILQ F+L+    P  + L P   G
Sbjct: 421 DGRFRKHEAFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSLESPCPPDTLSLKPTVSG 480

Query: 478 FGCIPPRYKLCVIP 491
              IPP ++L V P
Sbjct: 481 LFNIPPAFQLQVRP 494


>gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide 2
           [Homo sapiens]
          Length = 502

 Score =  363 bits (933), Expect = e-100
 Identities = 194/485 (40%), Positives = 283/485 (58%), Gaps = 7/485 (1%)

Query: 10  LLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFT 69
           LL   AFLL     ++     N PPGP+ LP +GN F ++ +          +++G +F+
Sbjct: 22  LLGTVAFLLAADFLKRRRPK-NYPPGPWRLPFLGNFFLVDFEQSHLEVQLFVKKYGNLFS 80

Query: 70  LYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLP-AFHAHRDRGIIFNNGPTWKDIRRF 128
           L +G    V++ G   +KEAL+     F  R   P   H  +  G+I ++G  WK+ RRF
Sbjct: 81  LELGDISAVLITGLPLIKEALIHMDQNFGNRPVTPMREHIFKKNGLIMSSGQAWKEQRRF 140

Query: 129 SLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKH 188
           +LT LRN+G+GK+  E RIQ EA  L EA+++  GQPFDP F I  A  N+I  I F + 
Sbjct: 141 TLTALRNFGLGKKSLEERIQEEAQHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGER 200

Query: 189 FDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSE 248
           F+Y D  F +L+ L +E  +L ++   QLYN FP  + +LPG H+ +  N  ++K +VS 
Sbjct: 201 FEYQDSWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSNWKKLKLFVSH 260

Query: 249 RVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTL 308
            + +H +  +P   RD  D  L EM K   +    +  + +  +  DLFFAGTETTSTTL
Sbjct: 261 MIDKHRKDWNPAETRDFIDAYLKEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTL 320

Query: 309 RYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNL 368
           R+ LL +  YPEI+EK+  EIDRVIG  + P+   R+ MPY +AV+HE+QR   ++P N+
Sbjct: 321 RWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNV 380

Query: 369 PHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFK 428
           P E T DT   GY +PKGT+++  L ++  D  E+  P+ F P+HFL ENG+FK  + F 
Sbjct: 381 PREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFL-ENGQFKKREAFM 439

Query: 429 PFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLS-PIHIGFGCIPPRYKL 487
           PFS GKR C GE LAR ELF+   +++Q F  +P   P +  LS    +G    P  ++L
Sbjct: 440 PFSIGKRACLGEQLARTELFIFFTSLMQKFTFRP---PNNEKLSLKFRMGITISPVSHRL 496

Query: 488 CVIPR 492
           C +P+
Sbjct: 497 CAVPQ 501


>gi|40805836 cytochrome P450, family 2, subfamily D, polypeptide 6
           isoform 1 [Homo sapiens]
          Length = 497

 Score =  340 bits (872), Expect = 2e-93
 Identities = 200/498 (40%), Positives = 287/498 (57%), Gaps = 18/498 (3%)

Query: 6   VTVALLVWAAFLLLVS-MWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRF 64
           V +A++V A FLLLV  M R+   +   PPGP PLP +GNL  ++ +N P  F +L +RF
Sbjct: 7   VPLAVIV-AIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRF 65

Query: 65  GPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFH----AHRDRGIIFNN-G 119
           G VF+L +    +VV++G  AV+EAL+ + ++ + R  +P         R +G+     G
Sbjct: 66  GDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYG 125

Query: 120 PTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNV 179
           P W++ RRFS++TLRN G+GK+  E  +  EA  L  A     G+PF P  L+  A  NV
Sbjct: 126 PAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNV 185

Query: 180 IADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNV 239
           IA +   + F+Y+D +FLRL+ L  E     S    ++ N  P  LH +P    KV++  
Sbjct: 186 IASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLH-IPALAGKVLRFQ 244

Query: 240 AEVKEYVSERVKEHHQSLDP-NCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFF 298
                 + E + EH  + DP   PRDLT+  L EMEK K + E  +  + + + VADLF 
Sbjct: 245 KAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFS 304

Query: 299 AGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQ 358
           AG  TTSTTL +GLL+++ +P+++ ++ +EID VIG  R P + D+  MPY  AV+HE+Q
Sbjct: 305 AGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQ 364

Query: 359 RFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNEN 418
           RF  +VP  + H  +RD   +G+ IPKGT ++  L SVL D   +  P +F PEHFL+  
Sbjct: 365 RFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQ 424

Query: 419 GKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLK-PLVDPKDIDLSPIHIG 477
           G F   + F PFS G+R C GE LARMELFL   ++LQHF+   P   P+     P H G
Sbjct: 425 GHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPR-----PSHHG 479

Query: 478 ---FGCIPPRYKLCVIPR 492
              F   P  Y+LC +PR
Sbjct: 480 VFAFLVTPSPYELCAVPR 497


>gi|64368472 cytochrome P450, family 2, subfamily W, polypeptide 1
           [Homo sapiens]
          Length = 490

 Score =  326 bits (836), Expect = 3e-89
 Identities = 185/466 (39%), Positives = 273/466 (58%), Gaps = 14/466 (3%)

Query: 33  PPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLD 92
           PPGP PLP++GNL  L L    +S   L++R+GPVFT+++G Q+ VV+ G++AVKEAL  
Sbjct: 32  PPGPRPLPLVGNLHLLRLSQQDRSLMELSERYGPVFTVHLGRQKTVVLTGFEAVKEALAG 91

Query: 93  YKDEFSGRGDLPAFHA-HRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREA 151
              E + R  +  F    R  GI F++G  W+  R+F++  L + G+G++    +I +E 
Sbjct: 92  PGQELADRPPIAIFQLIQRGGGIFFSSGARWRAARQFTVRALHSLGVGREPVADKILQEL 151

Query: 152 HFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLS 211
             L   L   +G+PF P  L+G AP N+   +LF + FDY D  F+ L+ L +E   LL 
Sbjct: 152 KCLSGQLDGYRGRPF-PLALLGWAPSNITFALLFGRRFDYRDPVFVSLLGLIDEVMVLLG 210

Query: 212 TPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVS---ERVKEHHQSLDPNCPRDLTDC 268
           +P LQL+N +P +L  L   HR V++ + EV+  +    E  + H    DP C     D 
Sbjct: 211 SPGLQLFNVYP-WLGALLQLHRPVLRKIEEVRAILRTLLEARRPHVCPGDPVC--SYVDA 267

Query: 269 LLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEE 328
           L+ + + +    E L+          D+  AGTETTS TL++  L++ ++P+++ ++ EE
Sbjct: 268 LIQQGQGD--DPEGLFAEANAVACTLDMVMAGTETTSATLQWAALLMGRHPDVQGRVQEE 325

Query: 329 IDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTV 388
           +DRV+GP R P ++D+Q +PY  AV+HE+QRFITL+P ++P     DT   G+L+PKGT 
Sbjct: 326 LDRVLGPGRTPRLEDQQALPYTSAVLHEVQRFITLLP-HVPRCTAADTQLGGFLLPKGTP 384

Query: 389 VVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELF 448
           V+P L SVL D  ++  P +F P HFL+ NG F   + F PFS G+RVC GE LAR ELF
Sbjct: 385 VIPLLTSVLLDETQWQTPGQFNPGHFLDANGHFVKREAFLPFSAGRRVCVGERLARTELF 444

Query: 449 LLLCAILQHFNL--KPLVDPKDIDLSPIHIGFGCIPPRYKLCVIPR 492
           LL   +LQ + L   P V P  +D +P    F   P    LC +PR
Sbjct: 445 LLFAGLLQRYRLLPPPGVSPASLDTTPAR-AFTMRPRAQALCAVPR 489


>gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide 1
           [Homo sapiens]
          Length = 501

 Score =  301 bits (771), Expect = 9e-82
 Identities = 178/494 (36%), Positives = 279/494 (56%), Gaps = 15/494 (3%)

Query: 2   SALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKN-IPKSFTRL 60
           +ALG  + LL++A   L V    +       PPGP  LP IGN++ L   + +P  + R 
Sbjct: 12  AALGGALFLLLFA---LGVRQLLKQRRPMGFPPGPPGLPFIGNIYSLAASSELPHVYMRK 68

Query: 61  -AQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNN- 118
            +Q +G +F+L +G    VV++GY  VKE L+   + F+ R  LP F      G + N+ 
Sbjct: 69  QSQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSR 128

Query: 119 -GPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPC 177
            G  W D RR ++ + R +G G++  ES+I  E  F  +A+   +G+PFD   LI  A  
Sbjct: 129 YGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVS 188

Query: 178 NVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLP-GSHRKVI 236
           N+   I+F + F Y D  F  ++ LF+EN  L ++  + LYN FP ++  LP G H+++ 
Sbjct: 189 NITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFP-WIGILPFGKHQQLF 247

Query: 237 KNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADL 296
           +N A V +++S  +++   +  P  P+   D  L EM++ K+     ++ + +  +V +L
Sbjct: 248 RNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGEL 307

Query: 297 FFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHE 356
             AGTETT+  LR+ +L +  YP I+ ++ +EID ++GP+  P+  D+ +MPY +AV+HE
Sbjct: 308 IIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHE 367

Query: 357 IQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLN 416
           + RF  +VP  + H  + D + RGY IPKGT V+  L SV +D + + DPE F PE FL+
Sbjct: 368 VLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLD 427

Query: 417 ENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDI--DLSPI 474
            +G F   +   PFS G+R C GE LARME+FL   A+LQ F+L     P ++  DL P 
Sbjct: 428 SSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLH---FPHELVPDLKP- 483

Query: 475 HIGFGCIPPRYKLC 488
            +G    P  Y +C
Sbjct: 484 RLGMTLQPQPYLIC 497


>gi|68509921 cytochrome P450, family 2, subfamily D, polypeptide 6
           isoform 2 [Homo sapiens]
          Length = 446

 Score =  293 bits (749), Expect = 3e-79
 Identities = 182/493 (36%), Positives = 265/493 (53%), Gaps = 59/493 (11%)

Query: 6   VTVALLVWAAFLLLVS-MWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRF 64
           V +A++V A FLLLV  M R+   +   PPGP PLP +GNL  ++ +N P  F +L +RF
Sbjct: 7   VPLAVIV-AIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRF 65

Query: 65  GPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGPTWKD 124
           G VF+L +    +VV++G  AV+EAL+ + ++ + R  +P                    
Sbjct: 66  GDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVP-------------------- 105

Query: 125 IRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADIL 184
                +T +  +G                      ++QG+PF P  L+  A  NVIA + 
Sbjct: 106 -----ITQILGFGP---------------------RSQGRPFRPNGLLDKAVSNVIASLT 139

Query: 185 FRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKE 244
             + F+Y+D +FLRL+ L  E     S    ++ N  P  LH +P    KV++       
Sbjct: 140 CGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLH-IPALAGKVLRFQKAFLT 198

Query: 245 YVSERVKEHHQSLDP-NCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTET 303
            + E + EH  + DP   PRDLT+  L EMEK K + E  +  + + + VADLF AG  T
Sbjct: 199 QLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMVT 258

Query: 304 TSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITL 363
           TSTTL +GLL+++ +P+++ ++ +EID VIG  R P + D+  MPY  AV+HE+QRF  +
Sbjct: 259 TSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDI 318

Query: 364 VPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKY 423
           VP  + H  +RD   +G+ IPKGT ++  L SVL D   +  P +F PEHFL+  G F  
Sbjct: 319 VPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVK 378

Query: 424 SDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLK-PLVDPKDIDLSPIHIG---FG 479
            + F PFS G+R C GE LARMELFL   ++LQHF+   P   P+     P H G   F 
Sbjct: 379 PEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPR-----PSHHGVFAFL 433

Query: 480 CIPPRYKLCVIPR 492
             P  Y+LC +PR
Sbjct: 434 VTPSPYELCAVPR 446


>gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide 1
           [Homo sapiens]
          Length = 544

 Score =  287 bits (734), Expect = 2e-77
 Identities = 159/477 (33%), Positives = 271/477 (56%), Gaps = 28/477 (5%)

Query: 9   ALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLEL------KNIPKSFTR--- 59
           ALL+     LL   W +   +  +PPGP P P++GN   + L      ++   S TR   
Sbjct: 36  ALLLCGLVALLGWSWLRRRRARGIPPGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTRAAG 95

Query: 60  --------------LAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPA 105
                         LA+ +G +F+ ++G   +VV+  + +V+EAL+   + FS R  +P 
Sbjct: 96  IDPSVIGPQVLLAHLARVYGSIFSFFIGHYLVVVLSDFHSVREALVQQAEVFSDRPRVPL 155

Query: 106 FH-AHRDRGIIFNN-GPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQG 163
                +++G++F + GP W+  R+FS +TLR++G+GK   E +I  E  ++   ++K   
Sbjct: 156 ISIVTKEKGVVFAHYGPVWRQQRKFSHSTLRHFGLGKLSLEPKIIEEFKYVKAEMQKHGE 215

Query: 164 QPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPS 223
            PF P  +I  A  N+I  + F + FDY + +F +++   +    +     + L N  P 
Sbjct: 216 DPFCPFSIISNAVSNIICSLCFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVLLVNICP- 274

Query: 224 FLHYLPGSHRKVIKNVA-EVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKE-KHSAE 281
           +L+YLP    K ++ +  ++  ++ + +K+H +SLD   P+D  D  L+ ME+E K+++ 
Sbjct: 275 WLYYLPFGPFKELRQIEKDITSFLKKIIKDHQESLDRENPQDFIDMYLLHMEEERKNNSN 334

Query: 282 RLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAI 341
             +  + +   + DLF AGT+TT+ +L + LL +   P+++EK+HEEI+RVIG +R P++
Sbjct: 335 SSFDEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSL 394

Query: 342 KDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQ 401
            D+ +MPY +A + E+QR   +VP  +PH  + +T+ +GY IPKGT+++P L SV  D  
Sbjct: 395 TDKAQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPA 454

Query: 402 EFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHF 458
            +  PE F P  FL++ G+    + F PF  GKRVC GE LA+MELFL+  +++Q F
Sbjct: 455 IWEKPEDFYPNRFLDDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSF 511


>gi|4503199 cytochrome P450, family 1, subfamily A, polypeptide 1
           [Homo sapiens]
          Length = 512

 Score =  226 bits (576), Expect = 4e-59
 Identities = 152/493 (30%), Positives = 254/493 (51%), Gaps = 23/493 (4%)

Query: 1   MSALGVTVALLVWAAFLLLVSMWR-QVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTR 59
           MSA    +A +++     ++   R QV      PPGP+  P+IG++  L  KN   + +R
Sbjct: 7   MSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLG-KNPHLALSR 65

Query: 60  LAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHA-HRDRGIIFN- 117
           ++Q++G V  + +GS  +VV+ G   +++AL+   D+F GR DL  F      + + F+ 
Sbjct: 66  MSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSP 125

Query: 118 -NGPTWKDIRRFSLTTLRNYGMGKQGN-------ESRIQREAHFLLEALRKTQGQP--FD 167
            +GP W   RR +   L+++ +            E  + +EA  L+  L++    P  F+
Sbjct: 126 DSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFN 185

Query: 168 PTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHY 227
           P   +  +  NVI  I F + +D+N ++ L L+ L N NF  +         +F   L Y
Sbjct: 186 PYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNL-NNNFGEVVGSGNPA--DFIPILRY 242

Query: 228 LPGSHRKVIKNVAE-VKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEK--HSAERLY 284
           LP       K++ E    ++ + VKEH+++ +    RD+TD L+   ++++   +A    
Sbjct: 243 LPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQL 302

Query: 285 TMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDR 344
           + + I   V DLF AG +T +T + + L+ L+  P ++ K+ EE+D VIG SR P + DR
Sbjct: 303 SDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDR 362

Query: 345 QEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFP 404
             +PYM+A + E  R  + VP  +PH  TRDT  +G+ IPKG  V      + +D + + 
Sbjct: 363 SHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWV 422

Query: 405 DPEKFKPEHFLNENGKFK--YSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKP 462
           +P +F PE FL  +G      S+    F  GKR C GE +AR E+FL L  +LQ      
Sbjct: 423 NPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSV 482

Query: 463 LVDPKDIDLSPIH 475
            +  K +D++PI+
Sbjct: 483 PLGVK-VDMTPIY 494


>gi|73915100 cytochrome P450, family 1, subfamily A, polypeptide 2
           [Homo sapiens]
          Length = 516

 Score =  213 bits (541), Expect = 4e-55
 Identities = 146/478 (30%), Positives = 240/478 (50%), Gaps = 25/478 (5%)

Query: 16  FLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQ 75
           F +L  +  +V      PP P+  P++G++  L  KN   + +R++QR+G V  + +GS 
Sbjct: 25  FWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLG-KNPHLALSRMSQRYGDVLQIRIGST 83

Query: 76  RMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRD-RGIIFN--NGPTWKDIRRFSLTT 132
            ++V+     +++AL+   D+F GR DL       D + + F+  +GP W   RR +   
Sbjct: 84  PVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNA 143

Query: 133 LRNYGMGKQGN-------ESRIQREAHFLLEALRKTQGQP--FDPTFLIGCAPCNVIADI 183
           L  + +            E  + +EA  L+  L++    P  FDP   +  +  NVI  +
Sbjct: 144 LNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAM 203

Query: 184 LFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAE-V 242
            F +HF  + ++ L L+   +E     S+      + FP  L YLP    +  K   +  
Sbjct: 204 CFGQHFPESSDEMLSLVKNTHEFVETASSG--NPLDFFP-ILRYLPNPALQRFKAFNQRF 260

Query: 243 KEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTE 302
             ++ + V+EH+Q  D N  RD+T  L    +K   ++  L   + I   V D+F AG +
Sbjct: 261 LWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFD 320

Query: 303 TTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFIT 362
           T +T + + L+ L+  PEI+ K+ +E+D VIG  R P + DR ++PY++A + E  R  +
Sbjct: 321 TVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSS 380

Query: 363 LVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENG--- 419
            +P  +PH  TRDT   G+ IPK   V      V +D + + DP +F+PE FL  +G   
Sbjct: 381 FLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAI 440

Query: 420 KFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQ--HFNLKPLVDPKDIDLSPIH 475
               S+    F  GKR C GE LA+ E+FL L  +LQ   F++ P V    +DL+PI+
Sbjct: 441 NKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGV---KVDLTPIY 495


>gi|189491763 cytochrome P450, family 1, subfamily B, polypeptide 1
           [Homo sapiens]
          Length = 543

 Score =  210 bits (535), Expect = 2e-54
 Identities = 153/482 (31%), Positives = 243/482 (50%), Gaps = 57/482 (11%)

Query: 17  LLLVSMWRQVHSSWNL-----------PPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFG 65
           LLL+S+   VH    L           PPGPF  P+IGN   +  +    SF RLA+R+G
Sbjct: 24  LLLLSVLATVHVGQRLLRQRRRQLRSAPPGPFAWPLIGNAAAVG-QAAHLSFARLARRYG 82

Query: 66  PVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHR----DRGIIFNN-GP 120
            VF + +GS  +VV++G +A+ +AL+     F+ R   PAF + R     R + F +   
Sbjct: 83  DVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADR---PAFASFRVVSGGRSMAFGHYSE 139

Query: 121 TWKDIRRFSLTTLRNY----GMGKQGNESRIQREAHFLLEALRK--TQGQPFDPTFLIGC 174
            WK  RR + + +RN+       +Q  E  +  EA  L+  L +    G   DP  L   
Sbjct: 140 HWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSADGAFLDPRPLTVV 199

Query: 175 APCNVIADILFRKHFDYNDEKFLRLMYLFNENF-------HLLST-PWLQLYNNFPSFLH 226
           A  NV++ + F   + ++D +F  L+   NE F        L+   PWLQ          
Sbjct: 200 AVANVMSAVCFGCRYSHDDPEFRELLS-HNEEFGRTVGAGSLVDVMPWLQ---------- 248

Query: 227 YLPGSHRKVIKNVAEVKE----YVSERVKEHHQSLDPNC-PRDLTDCLLVEMEK----EK 277
           Y P   R V +   ++      ++ ++   H +SL P   PRD+ D  ++  EK    + 
Sbjct: 249 YFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAGDS 308

Query: 278 HSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSR 337
           H       ++ +  T+ D+F A  +T ST L++ LL+  +YP+++ ++  E+D+V+G  R
Sbjct: 309 HGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDR 368

Query: 338 IPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVL 397
           +P + D+  +PY+ A ++E  RF + VP  +PH  T +T   GY IPK TVV     SV 
Sbjct: 369 LPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVN 428

Query: 398 YDNQEFPDPEKFKPEHFLNENGKFK--YSDYFKPFSTGKRVCAGEGLARMELFLLLCAIL 455
           +D  ++P+PE F P  FL+++G      +     FS GKR C GE L++M+LFL + +IL
Sbjct: 429 HDPLKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFI-SIL 487

Query: 456 QH 457
            H
Sbjct: 488 AH 489


>gi|4503195 cytochrome P450, family 17 [Homo sapiens]
          Length = 508

 Score =  186 bits (471), Expect = 5e-47
 Identities = 135/449 (30%), Positives = 237/449 (52%), Gaps = 30/449 (6%)

Query: 33  PPGPFPLPIIGNL-FQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALL 91
           P     LP++G+L F     ++  +F +L +++GP++++ +G++  V++  ++  KE L+
Sbjct: 28  PKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLI 87

Query: 92  DYKDEFSGRGDLPAFH--AHRDRGIIF-NNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQ 148
               +FSGR  +      ++  +GI F ++G  W+  RR ++ T   +  G Q  E  I 
Sbjct: 88  KKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIIC 147

Query: 149 REAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENF- 207
           +E   L + L    GQ  D +F +  A  NVI+ I F   +   D + L ++  +NE   
Sbjct: 148 QEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPE-LNVIQNYNEGII 206

Query: 208 ------HLLS-TPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPN 260
                  L+   PWL+++ N    L  L  SH K I+N  ++   + E  KE  +S   +
Sbjct: 207 DNLSKDSLVDLVPWLKIFPN--KTLEKLK-SHVK-IRN--DLLNKILENYKEKFRS---D 257

Query: 261 CPRDLTDCLL-VEMEKEKHSA-----ERLYTMDGITVTVADLFFAGTETTSTTLRYGLLI 314
              ++ D L+  +M  +  +A       L + + I  T+ D+F AG ETT++ +++ L  
Sbjct: 258 SITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAF 317

Query: 315 LMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATR 374
           L+  P++++KL+EEID+ +G SR P I DR  +  ++A + E+ R   + P  +PH+A  
Sbjct: 318 LLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANV 377

Query: 375 DTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGK--FKYSDYFKPFST 432
           D+    + + KGT V+  L ++ ++ +E+  P++F PE FLN  G      S  + PF  
Sbjct: 378 DSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGA 437

Query: 433 GKRVCAGEGLARMELFLLLCAILQHFNLK 461
           G R C GE LAR ELFL++  +LQ F+L+
Sbjct: 438 GPRSCIGEILARQELFLIMAWLLQRFDLE 466


>gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide 2
           isoform a [Homo sapiens]
          Length = 495

 Score =  179 bits (455), Expect = 4e-45
 Identities = 136/482 (28%), Positives = 234/482 (48%), Gaps = 42/482 (8%)

Query: 1   MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRL 60
           M  LG+ + L + A   LL + W+    S +LPP      +      L   ++P     L
Sbjct: 1   MLLLGLLLLLPLLAGARLLWNWWKL--RSLHLPP------LAPGFLHLLQPDLPIYLLGL 52

Query: 61  AQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGP 120
            Q+FGP++ L++G Q +VV++  + ++EA++    +F+GR +   +       ++  N P
Sbjct: 53  TQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYK------LVSRNYP 106

Query: 121 T---------WKDIRRFSLTTLRNYGMG-KQGNESRIQREAHFLLEALRKTQGQPFDPTF 170
                     WK  ++ + + L    +G +   E  +++      E +R   G P     
Sbjct: 107 DLSLGDYSLLWKAHKKLTRSALL---LGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEE 163

Query: 171 LIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPW-LQLYNNFPSFLHYLP 229
                 C++I  + F       D+  +   Y   +      + W +Q+ +  P FL + P
Sbjct: 164 EFSLLTCSIICYLTFGDKI--KDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIP-FLRFFP 220

Query: 230 GSHRKVIKNVAEVKEYVSE-RVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDG 288
               + +K   E ++++ E ++++H +SL     RD+ D +L  + +          ++G
Sbjct: 221 NPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEG 280

Query: 289 -ITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGP----SRIPAIKD 343
            + +   DL   GTETT+ TL + ++ L+ +PEI+++L EE+D  +GP    SR+P  KD
Sbjct: 281 HVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVP-YKD 339

Query: 344 RQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEF 403
           R  +P ++A + E+ R   +VP  LPH  TR +   GY IP+GTV++P L     D   +
Sbjct: 340 RARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVW 399

Query: 404 PDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPL 463
             P +F P+ FL E GK   +     F  G RVC GE LAR+ELF++L  +LQ F L P 
Sbjct: 400 ERPHEFWPDRFL-EPGK---NSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPS 455

Query: 464 VD 465
            D
Sbjct: 456 GD 457


>gi|190570174 cytochrome P450, family 21, subfamily A, polypeptide 2
           isoform b [Homo sapiens]
          Length = 465

 Score =  163 bits (413), Expect = 3e-40
 Identities = 132/473 (27%), Positives = 219/473 (46%), Gaps = 54/473 (11%)

Query: 1   MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRL 60
           M  LG+ + L + A   LL + W+    S +LPP      +      L   ++P     L
Sbjct: 1   MLLLGLLLLLPLLAGARLLWNWWKL--RSLHLPP------LAPGFLHLLQPDLPIYLLGL 52

Query: 61  AQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGP 120
            Q+FGP++ L++G Q  +V   Y  +  +L DY                           
Sbjct: 53  TQKFGPIYRLHLGLQDKLVSRNYPDL--SLGDYS-------------------------L 85

Query: 121 TWKDIRRFSLTTLRNYGMG-KQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNV 179
            WK  ++ + + L    +G +   E  +++      E +R   G P           C++
Sbjct: 86  LWKAHKKLTRSALL---LGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSI 142

Query: 180 IADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPW-LQLYNNFPSFLHYLPGSHRKVIKN 238
           I  + F       D+  +   Y   +      + W +Q+ +  P FL + P    + +K 
Sbjct: 143 ICYLTFGDKI--KDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIP-FLRFFPNPGLRRLKQ 199

Query: 239 VAEVKEYVSE-RVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDG-ITVTVADL 296
             E ++++ E ++++H +SL     RD+ D +L  + +          ++G + +   DL
Sbjct: 200 AIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDL 259

Query: 297 FFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGP----SRIPAIKDRQEMPYMDA 352
              GTETT+ TL + ++ L+ +PEI+++L EE+D  +GP    SR+P  KDR  +P ++A
Sbjct: 260 LIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVP-YKDRARLPLLNA 318

Query: 353 VVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPE 412
            + E+ R   +VP  LPH  TR +   GY IP+GTV++P L     D   +  P +F P+
Sbjct: 319 TIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPD 378

Query: 413 HFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVD 465
            FL E GK   +     F  G RVC GE LAR+ELF++L  +LQ F L P  D
Sbjct: 379 RFL-EPGK---NSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGD 427


>gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide 2
           [Homo sapiens]
          Length = 525

 Score =  118 bits (295), Expect = 1e-26
 Identities = 121/486 (24%), Positives = 208/486 (42%), Gaps = 46/486 (9%)

Query: 2   SALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLA 61
           SAL +  A LV +    + S  R+      +P      P++G+   ++     + F ++ 
Sbjct: 20  SALSLAGASLVLSLLQRVASYARKWQQMRPIPTVARAYPLVGHALLMKPDG-REFFQQII 78

Query: 62  Q-----RFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIF 116
           +     R  P+  L+VG   MV ++  + V E +L    +                G++ 
Sbjct: 79  EYTEEYRHMPLLKLWVGPVPMVALYNAENV-EVILTSSKQIDKSSMYKFLEPWLGLGLLT 137

Query: 117 NNGPTWKDIRR-----FSLTTLRNYG--MGKQGNESRIQREAHFLLEALRKTQGQPFDPT 169
           + G  W+  R+     F  T L ++   M +Q N    + E H   EA        F+  
Sbjct: 138 STGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKHINQEA--------FNCF 189

Query: 170 FLIGCAPCNVIADILFRKHF---DYNDEKFLRLMYLFNEN-FHLLSTPWLQLYNNFPSFL 225
           F I     ++I +    K+      +D +++R +Y  +E  F  +  PWL L   +  F 
Sbjct: 190 FYITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFK 249

Query: 226 HYLPGSHRKVIKNVAE-VKEYVSERVKEHHQSLD-----------PNCPRDLTDCLLVEM 273
                 H+K ++ +       ++ER  E + + D            N  R   D LL   
Sbjct: 250 E--GWEHKKSLQILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLLSVT 307

Query: 274 EKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVI 333
           + E +        + I   V    F G +TT+  + + L +L   PE+++K+  E+D V 
Sbjct: 308 DDEGNRLSH----EDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVF 363

Query: 334 GPSRIPA-IKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPT 392
           G S  PA ++D +++ Y++ V+ E  R    VP       + D    GY + KGT  V  
Sbjct: 364 GKSDRPATVEDLKKLRYLECVIKETLRLFPSVPL-FARSVSEDCEVAGYRVLKGTEAVII 422

Query: 393 LDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLC 452
             ++  D + FP+PE+F+PE F  EN + ++   + PFS G R C G+  A ME   +L 
Sbjct: 423 PYALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILS 482

Query: 453 AILQHF 458
            IL+HF
Sbjct: 483 CILRHF 488


>gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1
           isoform 1 precursor [Homo sapiens]
          Length = 514

 Score =  113 bits (283), Expect = 3e-25
 Identities = 103/448 (22%), Positives = 195/448 (43%), Gaps = 40/448 (8%)

Query: 34  PGPFPLPIIGNLFQL----ELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEA 89
           PGP   P++G+L Q+     LK    +     +++G +F + +GS   V + G   + EA
Sbjct: 59  PGPTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHL-GSPCLLEA 117

Query: 90  LLDYKDEFSGRGDLPAFHAHRDR-----GIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNE 144
           L   +  +  R ++  + A+RD      G++   G  W+ +R      L      K G  
Sbjct: 118 LYRTESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLM-----KPGEV 172

Query: 145 SRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRL-MYLF 203
            ++  + +   E L    G+  +      C     + D+    + + N   F  + + L+
Sbjct: 173 MKLDNKIN---EVLADFMGRIDEL-----CDERGHVEDL----YSELNKWSFESICLVLY 220

Query: 204 NENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPR 263
            + F LL         NF   +  +  +  +++    E+ + ++ +V + H        +
Sbjct: 221 EKRFGLLQKNAGDEAVNFIMAIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFK 280

Query: 264 DLTDCLLVEMEKEKHSAERLYTMD----------GITVTVADLFFAGTETTSTTLRYGLL 313
            +  C+   +EK        +  D           +   V +L  A  ETT+ +L + L 
Sbjct: 281 SVKACIDNRLEKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILY 340

Query: 314 ILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEAT 373
            L + P++++KL +EI  V+  +++P  +D + MPY+ A + E  R    VP        
Sbjct: 341 NLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSVPFT-TRTLD 399

Query: 374 RDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTG 433
           + T+   Y +PKGTV++     +      F D  +F+PE +L E  K     +  PF  G
Sbjct: 400 KATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEKEKINPFAHL-PFGVG 458

Query: 434 KRVCAGEGLARMELFLLLCAILQHFNLK 461
           KR+C G  LA ++L L LC I++ ++++
Sbjct: 459 KRMCIGRRLAELQLHLALCWIVRKYDIQ 486


>gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide 4
           [Homo sapiens]
          Length = 503

 Score =  111 bits (278), Expect = 1e-24
 Identities = 113/446 (25%), Positives = 185/446 (41%), Gaps = 34/446 (7%)

Query: 34  PGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALL-D 92
           PGP PLP +GN+     K          +++G V+  Y G Q ++ +     +K  L+ +
Sbjct: 39  PGPTPLPFLGNILSYH-KGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKE 97

Query: 93  YKDEFSGRGDLPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAH 152
               F+ R         +   I       WK +R     T  +  + +      I +   
Sbjct: 98  CYSVFTNRRPFGPVGFMKS-AISIAEDEEWKRLRSLLSPTFTSGKLKEM--VPIIAQYGD 154

Query: 153 FLLEALRKTQ--GQPFDPTFLIGCAPCNVIADILFRKHFDY----------NDEKFLRLM 200
            L+  LR+    G+P     + G    +VI    F  + D           N +K LR  
Sbjct: 155 VLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFD 214

Query: 201 YLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPN 260
           +L          P+      FP  +  L   +  V     EV  ++ + VK   +S   +
Sbjct: 215 FL---------DPFFLSITVFPFLIPILEVLNICVFPR--EVTNFLRKSVKRMKESRLED 263

Query: 261 CPRDLTDCLLVEME----KEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILM 316
             +   D L + ++    KE  S + L  ++ +  ++    FAG ETTS+ L + +  L 
Sbjct: 264 TQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSII-FIFAGYETTSSVLSFIMYELA 322

Query: 317 KYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDT 376
            +P++++KL EEID V+     P      +M Y+D VV+E  R    +   L     +D 
Sbjct: 323 THPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFP-IAMRLERVCKKDV 381

Query: 377 IFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRV 436
              G  IPKG VV+    ++  D + + +PEKF PE F  +N        + PF +G R 
Sbjct: 382 EINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 441

Query: 437 CAGEGLARMELFLLLCAILQHFNLKP 462
           C G   A M + L L  +LQ+F+ KP
Sbjct: 442 CIGMRFALMNMKLALIRVLQNFSFKP 467


>gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 2 [Homo sapiens]
          Length = 503

 Score =  109 bits (272), Expect = 7e-24
 Identities = 121/467 (25%), Positives = 204/467 (43%), Gaps = 49/467 (10%)

Query: 34  PGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALL-D 92
           PGP PLP +G +    L+ +        +++G ++ LY G Q M+V+     +K  L+ +
Sbjct: 39  PGPTPLPFLGTIL-FYLRGLWNFDRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKE 97

Query: 93  YKDEFSGRGDLPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAH 152
               F+ +  L      +   + F     WK IR        +    +      I +   
Sbjct: 98  CYSVFTNQMPLGPMGFLKS-ALSFAEDEEWKRIRTLLSPAFTSVKFKEM--VPIISQCGD 154

Query: 153 FLLEALRKT--QGQPFDPTFLIGCAPCNVIADILFRKHFDY----------NDEKFLRLM 200
            L+ +LR+     +  +     G    +VI   LF  + D           N +K L+L 
Sbjct: 155 MLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLD 214

Query: 201 YLFNENFHLLS------TPWLQLYNN--FPSFL-HYLPGSHRKVIKNVAEVKEYVSERVK 251
           +L  + F LL       TP  +  N   FP  + H+L  S  ++ ++   +K+    RV 
Sbjct: 215 FL--DPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLKNSIERMKES--RLKDKQKHRVD 270

Query: 252 EHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYG 311
              Q +D             +  KE  S + L  ++ +  ++  + FA  +TTSTTL + 
Sbjct: 271 FFQQMIDS------------QNSKETKSHKALSDLELVAQSII-IIFAAYDTTSTTLPFI 317

Query: 312 LLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDR-QEMPYMDAVVHEIQRFITLVPSNLPH 370
           +  L  +P++++KL EEID V+ P++ P   D   +M Y+D VV+E  R   +V S +  
Sbjct: 318 MYELATHPDVQQKLQEEIDAVL-PNKAPVTYDALVQMEYLDMVVNETLRLFPVV-SRVTR 375

Query: 371 EATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPF 430
              +D    G  IPKG  V+  + ++ +D + + +PEKF PE F  +N        + PF
Sbjct: 376 VCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSIDLYRYIPF 435

Query: 431 STGKRVCAGEGLARMELFLLLCAILQHFNLKPLVD---PKDIDLSPI 474
             G R C G   A   + L +   LQ+F+ KP  +   P  +D  PI
Sbjct: 436 GAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLPI 482


>gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5
           [Homo sapiens]
          Length = 502

 Score =  108 bits (269), Expect = 1e-23
 Identities = 118/478 (24%), Positives = 209/478 (43%), Gaps = 37/478 (7%)

Query: 4   LGVTVALLVWAAFLLLVSMWRQVHSSWNLP--PGPFPLPIIGNLFQLELKNIPKSFTRLA 61
           L V   LL+  + +LL     + H  +     PGP PLP++GN+     + + K  T   
Sbjct: 7   LAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYR-QGLWKFDTECY 65

Query: 62  QRFGPVFTLYVGSQRMVVMHGYKAVKEALL-DYKDEFSGRGDLPAFHAHRDRGIIFNNGP 120
           +++G ++  Y G   ++ +     ++  L+ +    F+ R  L      +   I      
Sbjct: 66  KKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKS-AISLAEDE 124

Query: 121 TWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKT--QGQPFDPTFLIGCAPCN 178
            WK IR     T  +  + +      I +    L+  LR+   +G+P     + G    +
Sbjct: 125 EWKRIRSLLSPTFTSGKLKEMF--PIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMD 182

Query: 179 VIADILFRKHFDY----------NDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYL 228
           VI    F  + D           + +KFL+  +L      ++  P+L       +   + 
Sbjct: 183 VITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFP 242

Query: 229 PGSHRKVIKNVAEVKEY-VSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMD 287
             +   + K+V  +K+  ++++ K     L           L+++ +  K +       D
Sbjct: 243 KDTINFLSKSVNRMKKSRLNDKQKHRLDFLQ----------LMIDSQNSKETESHKALSD 292

Query: 288 GITVTVADLF-FAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDR-Q 345
                 + +F FAG ETTS+ L + L  L  +P++++KL +EID V+ P++ P   D   
Sbjct: 293 LELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVL-PNKAPPTYDAVV 351

Query: 346 EMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPD 405
           +M Y+D VV+E  R    V   L     +D    G  IPKG++VV    ++ +D + + +
Sbjct: 352 QMEYLDMVVNETLRLFP-VAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTE 410

Query: 406 PEKFKPEHFLNENGKFKYSDY-FKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKP 462
           PE+F+PE F  +  K     Y + PF TG R C G   A M + L L  +LQ+F+ KP
Sbjct: 411 PEEFRPERFSKK--KDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKP 466


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.142    0.441 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,189,509
Number of Sequences: 37866
Number of extensions: 944455
Number of successful extensions: 2640
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 64
Number of HSP's successfully gapped in prelim test: 8
Number of HSP's that attempted gapping in prelim test: 2442
Number of HSP's gapped (non-prelim): 89
length of query: 493
length of database: 18,247,518
effective HSP length: 106
effective length of query: 387
effective length of database: 14,233,722
effective search space: 5508450414
effective search space used: 5508450414
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.5 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.