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Search of human proteins with 10190704
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|10190704 2,4-dienoyl CoA reductase 2 [Homo sapiens]
(292 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|10190704 2,4-dienoyl CoA reductase 2 [Homo sapiens] 585 e-167
gi|4503301 2,4-dienoyl CoA reductase 1 precursor [Homo sapiens] 154 7e-38
gi|19923817 peroxisomal trans-2-enoyl-CoA reductase [Homo sapiens] 152 3e-37
gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo... 110 1e-24
gi|40254992 carbonic reductase 4 [Homo sapiens] 92 7e-19
gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo ... 89 3e-18
gi|4758504 hydroxysteroid (17-beta) dehydrogenase 10 isoform 1 [... 87 2e-17
gi|7705925 dicarbonyl/L-xylulose reductase [Homo sapiens] 87 2e-17
gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo sapi... 84 1e-16
gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens] 75 9e-14
gi|83715985 hydroxysteroid (17-beta) dehydrogenase 10 isoform 2 ... 74 1e-13
gi|40254986 hydroxysteroid dehydrogenase like 2 [Homo sapiens] 74 2e-13
gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo sap... 69 4e-12
gi|66933014 3-hydroxybutyrate dehydrogenase, type 2 [Homo sapiens] 69 4e-12
gi|126723750 dehydrogenase/reductase (SDR family) member 4 like ... 69 5e-12
gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo s... 63 3e-10
gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo... 62 5e-10
gi|126723191 dehydrogenase/reductase (SDR family) member 4 like ... 58 9e-09
gi|4504505 hydroxysteroid (17-beta) dehydrogenase 4 [Homo sapiens] 57 2e-08
gi|223718074 hydroxysteroid (17-beta) dehydrogenase 1 [Homo sapi... 56 3e-08
gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens] 53 4e-07
gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo sa... 53 4e-07
gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens] 52 6e-07
gi|150247226 retinol dehydrogenase 16 [Homo sapiens] 50 2e-06
gi|38424085 short-chain dehydrogenase/reductase 10 isoform b [Ho... 50 3e-06
gi|4504503 hydroxysteroid (17-beta) dehydrogenase 2 [Homo sapiens] 49 4e-06
gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens] 49 5e-06
gi|166795268 retinol dehydrogenase 11 [Homo sapiens] 48 9e-06
gi|157739938 dehydrogenase/reductase (SDR family) member 7C [Hom... 48 1e-05
gi|38348362 short-chain dehydrogenase/reductase 10 isoform e [Ho... 48 1e-05
>gi|10190704 2,4-dienoyl CoA reductase 2 [Homo sapiens]
Length = 292
Score = 585 bits (1507), Expect = e-167
Identities = 292/292 (100%), Positives = 292/292 (100%)
Query: 1 MAQPPPDVEGDDCLPAYRHLFCPDLLRDKVAFITGGGSGIGFRIAEIFMRHGCHTVIASR 60
MAQPPPDVEGDDCLPAYRHLFCPDLLRDKVAFITGGGSGIGFRIAEIFMRHGCHTVIASR
Sbjct: 1 MAQPPPDVEGDDCLPAYRHLFCPDLLRDKVAFITGGGSGIGFRIAEIFMRHGCHTVIASR 60
Query: 61 SLPRVLTAARKLAGATGRRCLPLSMDVRAPPAVMAAVDQALKEFGRIDILINCAAGNFLC 120
SLPRVLTAARKLAGATGRRCLPLSMDVRAPPAVMAAVDQALKEFGRIDILINCAAGNFLC
Sbjct: 61 SLPRVLTAARKLAGATGRRCLPLSMDVRAPPAVMAAVDQALKEFGRIDILINCAAGNFLC 120
Query: 121 PAGALSFNAFKTVMDIDTSGTFNVSRVLYEKFFRDHGGVIVNITATLGNRGQALQVHAGS 180
PAGALSFNAFKTVMDIDTSGTFNVSRVLYEKFFRDHGGVIVNITATLGNRGQALQVHAGS
Sbjct: 121 PAGALSFNAFKTVMDIDTSGTFNVSRVLYEKFFRDHGGVIVNITATLGNRGQALQVHAGS 180
Query: 181 AKAAVDAMTRHLAVEWGPQNIRVNSLAPGPISGTEGLRRLGGPQASLSTKVTASPLQRLG 240
AKAAVDAMTRHLAVEWGPQNIRVNSLAPGPISGTEGLRRLGGPQASLSTKVTASPLQRLG
Sbjct: 181 AKAAVDAMTRHLAVEWGPQNIRVNSLAPGPISGTEGLRRLGGPQASLSTKVTASPLQRLG 240
Query: 241 NKTEIAHSVLYLASPLASYVTGAVLVADGGAWLTFPNGVKGLPDFASFSAKL 292
NKTEIAHSVLYLASPLASYVTGAVLVADGGAWLTFPNGVKGLPDFASFSAKL
Sbjct: 241 NKTEIAHSVLYLASPLASYVTGAVLVADGGAWLTFPNGVKGLPDFASFSAKL 292
>gi|4503301 2,4-dienoyl CoA reductase 1 precursor [Homo sapiens]
Length = 335
Score = 154 bits (390), Expect = 7e-38
Identities = 91/257 (35%), Positives = 134/257 (52%), Gaps = 1/257 (0%)
Query: 15 PAYRHLFCPDLLRDKVAFITGGGSGIGFRIAEIFMRHGCHTVIASRSLPRVLTAARKLAG 74
P + + P+ + KVAFITGGG+G+G + + G VIASR + + A +++
Sbjct: 46 PLQKAMLPPNSFQGKVAFITGGGTGLGKGMTTLLSSLGAQCVIASRKMDVLKATAEQISS 105
Query: 75 ATGRRCLPLSMDVRAPPAVMAAVDQALKEFGRIDILINCAAGNFLCPAGALSFNAFKTVM 134
TG + + DVR P V V + +K G +I+IN AAGNF+ P LS NA+KT+
Sbjct: 106 QTGNKVHAIQCDVRDPDMVQNTVSELIKVAGHPNIVINNAAGNFISPTERLSPNAWKTIT 165
Query: 135 DIDTSGTFNVSRVLYEKFFR-DHGGVIVNITATLGNRGQALQVHAGSAKAAVDAMTRHLA 193
DI +GT V+ + ++ + G ++IT G V + SAKA V+AM++ LA
Sbjct: 166 DIVLNGTAFVTLEIGKQLIKAQKGAAFLSITTIYAETGSGFVVPSASAKAGVEAMSKSLA 225
Query: 194 VEWGPQNIRVNSLAPGPISGTEGLRRLGGPQASLSTKVTASPLQRLGNKTEIAHSVLYLA 253
EWG +R N + PGPI RL + P RLG E+A+ +L
Sbjct: 226 AEWGKYGMRFNVIQPGPIKTKGAFSRLDPTGTFEKEMIGRIPCGRLGTVEELANLAAFLC 285
Query: 254 SPLASYVTGAVLVADGG 270
S AS++ GAV+ DGG
Sbjct: 286 SDYASWINGAVIKFDGG 302
>gi|19923817 peroxisomal trans-2-enoyl-CoA reductase [Homo sapiens]
Length = 303
Score = 152 bits (385), Expect = 3e-37
Identities = 90/258 (34%), Positives = 137/258 (53%), Gaps = 6/258 (2%)
Query: 18 RHLFCPDLLRDKVAFITGGGSGIGFRIAEIFMRHGCHTVIASRSLPRVLTAARKLAG--- 74
R P LL+ +VA +TGG +GIG I + + G + VIASR L R+ +AA +L
Sbjct: 8 RSYLAPGLLQGQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAADELQANLP 67
Query: 75 -ATGRRCLPLSMDVRAPPAVMAAVDQALKEFGRIDILINCAAGNFLCPAGALSFNAFKTV 133
R +P+ ++R V V L FG+I+ L+N G FL PA +S + V
Sbjct: 68 PTKQARVIPIQCNIRNEEEVNNLVKSTLDTFGKINFLVNNGGGQFLSPAEHISSKGWHAV 127
Query: 134 MDIDTSGTFNVSRVLYEKFFRDHGGVIVNITATLGNRGQALQVHAGSAKAAVDAMTRHLA 193
++ + +GTF + + +Y + ++HGG IVNI G L VH+G+A+A V +T+ LA
Sbjct: 128 LETNLTGTFYMCKAVYSSWMKEHGGSIVNIIVPT-KAGFPLAVHSGAARAGVYNLTKSLA 186
Query: 194 VEWGPQNIRVNSLAPGPISGTEGLRRLGG-PQASLSTKVTASPLQRLGNKTEIAHSVLYL 252
+EW IR+N +APG I + G Q+ P +R+G E++ V +L
Sbjct: 187 LEWACSGIRINCVAPGVIYSQTAVENYGSWGQSFFEGSFQKIPAKRIGVPEEVSSVVCFL 246
Query: 253 ASPLASYVTGAVLVADGG 270
SP AS++TG + DGG
Sbjct: 247 LSPAASFITGQSVDVDGG 264
>gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo
sapiens]
Length = 270
Score = 110 bits (275), Expect = 1e-24
Identities = 78/252 (30%), Positives = 128/252 (50%), Gaps = 13/252 (5%)
Query: 29 KVAFITGGGSGIGFRIAEIFMRHGCHTVIASRSLPRVLTAARKLAGATGRRCLPLSMDVR 88
KV +TGGG GIG I F+ G VI + ++L GA C DV
Sbjct: 10 KVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQELPGAVFILC-----DVT 64
Query: 89 APPAVMAAVDQALKEFGRIDILINCAAGNFLCPAGA--LSFNAFKTVMDIDTSGTFNVSR 146
V V + ++ FGR+D ++N AG+ P S F+ +++++ GT+ +++
Sbjct: 65 QEDDVKTLVSETIRRFGRLDCVVN-NAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLTK 123
Query: 147 VLYEKFFRDHGGVIVNITATLGNRGQALQVHAGSAKAAVDAMTRHLAVEWGPQNIRVNSL 206
+ + R G ++NI++ +G GQA V + K AV AMT+ LA++ P +RVN +
Sbjct: 124 LALP-YLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVNCI 182
Query: 207 APGPI---SGTEGLRRLGGPQASLSTKVTASPLQRLGNKTEIAHSVLYLASPLASYVTGA 263
+PG I E + P+A++ + A PL R+G E+ + ++LAS A++ TG
Sbjct: 183 SPGNIWTPLWEELAALMPDPRATIREGMLAQPLGRMGQPAEVGAAAVFLASE-ANFCTGI 241
Query: 264 VLVADGGAWLTF 275
L+ GGA L +
Sbjct: 242 ELLVTGGAELGY 253
>gi|40254992 carbonic reductase 4 [Homo sapiens]
Length = 237
Score = 91.7 bits (226), Expect = 7e-19
Identities = 72/246 (29%), Positives = 113/246 (45%), Gaps = 12/246 (4%)
Query: 28 DKVAFITGGGSGIGFRIAEIFMRHGCHTVIASRSLPRVLTAARKLAGATGRRCLPLSMDV 87
DKV + GG GIG +A++ R G + +R+L A+ AG G L S DV
Sbjct: 2 DKVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLE----GAKAAAGDLGGDHLAFSCDV 57
Query: 88 RAPPAVMAAVDQALKEFGRIDILINCAAGNFLCPAGALSFNAFKTVMDIDTSGTFNVSRV 147
V ++ K GR++ L+N A N + + + G+ +
Sbjct: 58 AKEHDVQNTFEELEKHLGRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLTCKA 117
Query: 148 LYEKFFRDHGGVIVNITATLGNRGQALQVHAGSAKAAVDAMTRHLAVEWGPQNIRVNSLA 207
+ GG IVN+ + +G +G + Q ++K + +R LA E + IRVN +A
Sbjct: 118 AMRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRVNVVA 177
Query: 208 PGPISGTEGLRRLGGPQASLSTKVTASPLQRLGNKTEIAHSVLYLASPLASYVTGAVLVA 267
PG + T+ + L + L + PL R G E+AH+V++L + Y+TG VLV
Sbjct: 178 PGFVH-TDMTKDL--KEEHLKKNI---PLGRFGETIEVAHAVVFLLE--SPYITGHVLVV 229
Query: 268 DGGAWL 273
DGG L
Sbjct: 230 DGGLQL 235
>gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo
sapiens]
Length = 278
Score = 89.4 bits (220), Expect = 3e-18
Identities = 77/252 (30%), Positives = 115/252 (45%), Gaps = 11/252 (4%)
Query: 24 DLLRDKVAFITGGGSGIGFRIAEIFMRHGCHTVIASRSLPRVLTAARKLAG----ATGRR 79
D L +KVA +T GIGF IA + G H V++SR V A L G TG
Sbjct: 28 DPLANKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQGEGLSVTGTV 87
Query: 80 CLPLSMDVRAPPAVMAAVDQALKEFGRIDILINCAAGN-FLCPAGALSFNAFKTVMDIDT 138
C + R V A+K G IDIL++ AA N F ++ + +DI+
Sbjct: 88 CHVGKAEDRE-----RLVATAVKLHGGIDILVSNAAVNPFFGSIMDVTEEVWDKTLDINV 142
Query: 139 SGTFNVSRVLYEKFFRDHGGVIVNITATLGNRGQALQVHAGSAKAAVDAMTRHLAVEWGP 198
+++ + + + GG +V +++ +K A+ +T+ LA+E P
Sbjct: 143 KAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIELAP 202
Query: 199 QNIRVNSLAPGPISGTEGLRRLGGPQASLSTKVTASPLQRLGNKTEIAHSVLYLASPLAS 258
+NIRVN LAPG I T R L + + ++RLG + A V +L S AS
Sbjct: 203 RNIRVNCLAPGLIK-TSFSRMLWMDKEKEESMKETLRIRRLGEPEDCAGIVSFLCSEDAS 261
Query: 259 YVTGAVLVADGG 270
Y+TG +V GG
Sbjct: 262 YITGETVVVGGG 273
>gi|4758504 hydroxysteroid (17-beta) dehydrogenase 10 isoform 1
[Homo sapiens]
Length = 261
Score = 86.7 bits (213), Expect = 2e-17
Identities = 76/252 (30%), Positives = 112/252 (44%), Gaps = 20/252 (7%)
Query: 30 VAFITGGGSGIGFRIAEIFMRHGCHTVIASRSLPRVLTAARKLAGATGRRCLPLSMDVRA 89
VA ITGG SG+G AE + G V+ A+KL G C+ DV +
Sbjct: 12 VAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKL----GNNCVFAPADVTS 67
Query: 90 PPAVMAAVDQALKEFGRIDILINCAAGNFLCPAGAL------SFNAFKTVMDIDTSGTFN 143
V A+ A +FGR+D+ +NCA L + F+ V+D++ GTFN
Sbjct: 68 EKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNLMGTFN 127
Query: 144 VSRVLYEKFFR---DHGG---VIVNITATLGNRGQALQVHAGSAKAAVDAMTRHLAVEWG 197
V R++ + + D GG VI+N + GQ Q ++K + MT +A +
Sbjct: 128 VIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLA 187
Query: 198 PQNIRVNSLAPGPISGTEGLRRLGGPQASLSTKVTASPLQRLGNKTEIAHSVLYLASPLA 257
P IRV ++APG + GT L L + P RLG+ E AH V +
Sbjct: 188 PIGIRVMTIAPG-LFGTPLLTSLPEKVCNFLASQVPFP-SRLGDPAEYAHLVQAIIE--N 243
Query: 258 SYVTGAVLVADG 269
++ G V+ DG
Sbjct: 244 PFLNGEVIRLDG 255
>gi|7705925 dicarbonyl/L-xylulose reductase [Homo sapiens]
Length = 244
Score = 86.7 bits (213), Expect = 2e-17
Identities = 64/248 (25%), Positives = 110/248 (44%), Gaps = 11/248 (4%)
Query: 26 LRDKVAFITGGGSGIGFRIAEIFMRHGCHTVIASRSLPRVLTAARKLAGATGRRCLPLSM 85
L + +TG G GIG + G V SR+ + + R+ G P+ +
Sbjct: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIE-----PVCV 59
Query: 86 DVRAPPAVMAAVDQALKEFGRIDILINCAAGNFLCPAGALSFNAFKTVMDIDTSGTFNVS 145
D+ A ++AL G +D+L+N AA L P ++ AF +++ VS
Sbjct: 60 DL----GDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVS 115
Query: 146 RVLYEKFF-RDHGGVIVNITATLGNRGQALQVHAGSAKAAVDAMTRHLAVEWGPQNIRVN 204
+++ R G IVN+++ R S K A+D +T+ +A+E GP IRVN
Sbjct: 116 QIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVN 175
Query: 205 SLAPGPISGTEGLRRLGGPQASLSTKVTASPLQRLGNKTEIAHSVLYLASPLASYVTGAV 264
++ P + + G P + T + PL + + +++L+L S + TG+
Sbjct: 176 AVNPTVVMTSMGQATWSDPHKA-KTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGST 234
Query: 265 LVADGGAW 272
L +GG W
Sbjct: 235 LPVEGGFW 242
>gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo
sapiens]
Length = 280
Score = 84.0 bits (206), Expect = 1e-16
Identities = 77/247 (31%), Positives = 112/247 (45%), Gaps = 6/247 (2%)
Query: 25 LLRDKVAFITGGGSGIGFRIAEIFMRHGCHTVIASRSLPRVLTAARKLAGATGRRCLPLS 84
+L ++VA +TG SGIGF IA R G H VI+SR V A KL G G +
Sbjct: 33 VLANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQG-EGLSVAGIV 91
Query: 85 MDVRAPPAVMAAVDQALKEFGRIDILINCAAGNFLCPAGAL--SFNAFKTVMDIDTSGTF 142
V V +AL+ G +D L+ C+AG L S + ++ ++
Sbjct: 92 CHVGKAEDREQLVAKALEHCGGVDFLV-CSAGVNPLVGSTLGTSEQIWDKILSVNVKSPA 150
Query: 143 NVSRVLYEKFFRDHGGVIVNITATLGNRGQALQVHAGSAKAAVDAMTRHLAVEWGPQNIR 202
+ L G VI+ + N AL V+ +K A+ +TR LA+E P++IR
Sbjct: 151 LLLSQLLPYMENRRGAVILVSSIAAYNPVVALGVY-NVSKTALLGLTRTLALELAPKDIR 209
Query: 203 VNSLAPGPISGTEGLRRLGGPQASLSTKVTASPLQRLGNKTEIAHSVLYLASPLASYVTG 262
VN + PG I T+ + G ++ LQR+G + A V +L SP ASYV G
Sbjct: 210 VNCVVPGIIK-TDFSKVFHGNESLWKNFKEHHQLQRIGESEDCAGIVSFLCSPDASYVNG 268
Query: 263 AVLVADG 269
+ G
Sbjct: 269 ENIAVAG 275
>gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens]
Length = 261
Score = 74.7 bits (182), Expect = 9e-14
Identities = 68/259 (26%), Positives = 114/259 (44%), Gaps = 17/259 (6%)
Query: 26 LRDKVAFITGGGSGIGFRIAEIFMRHGCHTVIASRSLPRVLTAARKLAGATGRRCLP--- 82
LR +A +TG GSGIG ++ G R L G + P
Sbjct: 9 LRSALALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGSKEGPPRGN 68
Query: 83 ---LSMDVRAPPAVMAAVDQALKEFGRI-DILINCAA---GNFLCPAGALSFNAFKTVMD 135
DV A ++Q F R ++++CA FL +S + + V+
Sbjct: 69 HAAFQADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLH---MSEDDWDKVIA 125
Query: 136 IDTSGTFNVSRVLYEKFFRDH-GGVIVNITATLGNRGQALQVHAGSAKAAVDAMTRHLAV 194
++ GTF V++ + + G I+NI++ +G G Q + ++KA V +T+ A
Sbjct: 126 VNLKGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLTQTAAR 185
Query: 195 EWGPQNIRVNSLAPGPISGTEGLRRLGGPQASLSTKVTASPLQRLGNKTEIAHSVLYLAS 254
E G IR NS+ PG I+ T +++ PQ + P+ LG+ ++A V +LAS
Sbjct: 186 ELGRHGIRCNSVLPGFIA-TPMTQKV--PQKVVDKITEMIPMGHLGDPEDVADVVAFLAS 242
Query: 255 PLASYVTGAVLVADGGAWL 273
+ Y+TG + GG ++
Sbjct: 243 EDSGYITGTSVEVTGGLFM 261
>gi|83715985 hydroxysteroid (17-beta) dehydrogenase 10 isoform 2
[Homo sapiens]
Length = 252
Score = 74.3 bits (181), Expect = 1e-13
Identities = 72/252 (28%), Positives = 105/252 (41%), Gaps = 29/252 (11%)
Query: 30 VAFITGGGSGIGFRIAEIFMRHGCHTVIASRSLPRVLTAARKLAGATGRRCLPLSMDVRA 89
VA ITGG SG+G AE + G V+ A+KL G C+ DV +
Sbjct: 12 VAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKL----GNNCVFAPADVTS 67
Query: 90 PPAVMAAVDQALKEFGRIDILINCAAGNFLCPAGAL------SFNAFKTVMDIDTSGTFN 143
V A+ A +FGR+D+ +NCA L + F+ V+D++ GTFN
Sbjct: 68 EKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNLMGTFN 127
Query: 144 VSRVLYEKFFR---DHG---GVIVNITATLGNRGQALQVHAGSAKAAVDAMTRHLAVEWG 197
V R++ + + D G GVI+N + GQ Q ++K + MT +A
Sbjct: 128 VIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIA---- 183
Query: 198 PQNIRVNSLAPGPISGTEGLRRLGGPQASLSTKVTASPLQRLGNKTEIAHSVLYLASPLA 257
LAP + GT L L + P RLG+ E AH V +
Sbjct: 184 ------RDLAPIGLFGTPLLTSLPEKVCNFLASQVPFP-SRLGDPAEYAHLVQAIIE--N 234
Query: 258 SYVTGAVLVADG 269
++ G V+ DG
Sbjct: 235 PFLNGEVIRLDG 246
>gi|40254986 hydroxysteroid dehydrogenase like 2 [Homo sapiens]
Length = 418
Score = 73.6 bits (179), Expect = 2e-13
Identities = 62/201 (30%), Positives = 95/201 (47%), Gaps = 11/201 (5%)
Query: 32 FITGGGSGIGFRIAEIFMRHGCHTVIASRS-------LPRVLTAARKLAGATGRRCLPLS 84
FITG GIG IA + G + VIA+++ L + TAA ++ A G + LP
Sbjct: 14 FITGASRGIGKAIALKAAKDGANIVIAAKTAQPHPKLLGTIYTAAEEIE-AVGGKALPCI 72
Query: 85 MDVRAPPAVMAAVDQALKEFGRIDILINCAAGNFLCPAGALSFNAFKTVMDIDTSGTFNV 144
+DVR + AAV++A+K+FG IDIL+N A+ L +M+++T GT+
Sbjct: 73 VDVRDEQQISAAVEKAIKKFGGIDILVNNASAISLTNTLDTPTKRLDLMMNVNTRGTYLA 132
Query: 145 SRVLYEKFFRDHGGVIVNITATLGNRGQALQVHAG--SAKAAVDAMTRHLAVEWGPQNIR 202
S+ + I+NI+ L + H AK + +A E+ + I
Sbjct: 133 SKACIPYLKKSKVAHILNISPPLNLNPVWFKQHCAYTIAKYGMSMYVLGMAEEFKGE-IA 191
Query: 203 VNSLAPGPISGTEGLRRLGGP 223
VN+L P T + LGGP
Sbjct: 192 VNALWPKTAIHTAAMDMLGGP 212
>gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo
sapiens]
Length = 300
Score = 69.3 bits (168), Expect = 4e-12
Identities = 72/246 (29%), Positives = 112/246 (45%), Gaps = 8/246 (3%)
Query: 25 LLRDKVAFITGGGSGIGFRIAEIFMRHGCHTVIASRSLPRVLTAARKLAGATGRRCLPLS 84
+L ++VA +TG SGIGF IA R G H VI+SR V A KL G G +
Sbjct: 33 VLANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQG-EGLSVAGIV 91
Query: 85 MDVRAPPAVMAAVDQALKEFGRIDILINCAAGNFLCPAGAL--SFNAFKTVMDIDTSGTF 142
V V +AL+ G +D L+ C+AG L S + ++ ++
Sbjct: 92 CHVGKAEDREQLVAKALEHCGGVDFLV-CSAGVNPLVGSTLGTSEQIWDKILSVNVKSPA 150
Query: 143 NVSRVLYEKFFRDHGGVIVNITATLGNRGQALQVHAGSAKAAVDAMTRHLAVEWGPQNIR 202
+ L G VI+ + N AL V+ +K A+ +TR LA+E P++IR
Sbjct: 151 LLLSQLLPYMENRRGAVILVSSIAAYNPVVALGVY-NVSKTALLGLTRTLALELAPKDIR 209
Query: 203 VNSLAPGPI-SGTEGLRRLGGPQASLSTKVTASPL--QRLGNKTEIAHSVLYLASPLASY 259
VN + PG I + + R+G SLS + + + + + LG++ + S A + +
Sbjct: 210 VNCVVPGIIKTDFSKVVRIGFMGMSLSGRTSRNIISCRGLGSQRTVQESCPSCALQMPAT 269
Query: 260 VTGAVL 265
TG L
Sbjct: 270 STGRTL 275
>gi|66933014 3-hydroxybutyrate dehydrogenase, type 2 [Homo sapiens]
Length = 245
Score = 69.3 bits (168), Expect = 4e-12
Identities = 69/254 (27%), Positives = 108/254 (42%), Gaps = 24/254 (9%)
Query: 26 LRDKVAFITGGGSGIGFRIAEIFMRHGCHTVIASRSLPRVLTAARKLAGATGRRCLPLSM 85
L KV +T GIG A F R G VIA+ L K G R +
Sbjct: 4 LDGKVIILTAAAQGIGQAAALAFAREGAK-VIATDINESKLQELEKYPGIQTR-----VL 57
Query: 86 DVRAPPAVMAAVDQALKEFGRIDILINCAA----GNFL-CPAGALSFNAFKTVMDIDTSG 140
DV + DQ E R+D+L N A G L C F+ M+++
Sbjct: 58 DVTKKKQI----DQFANEVERLDVLFNVAGFVHHGTVLDCEEKDWDFS-----MNLNVRS 108
Query: 141 TFNVSRVLYEKFFRDHGGVIVNITATLGN-RGQALQVHAGSAKAAVDAMTRHLAVEWGPQ 199
+ + + K G I+N+++ + +G + + KAAV +T+ +A ++ Q
Sbjct: 109 MYLMIKAFLPKMLAQKSGNIINMSSVASSVKGVVNRCVYSTTKAAVIGLTKSVAADFIQQ 168
Query: 200 NIRVNSLAPGPI---SGTEGLRRLGGPQASLSTKVTASPLQRLGNKTEIAHSVLYLASPL 256
IR N + PG + S E ++ G P+ + + + R EIA +YLAS
Sbjct: 169 GIRCNCVCPGTVDTPSLQERIQARGNPEEARNDFLKRQKTGRFATAEEIAMLCVYLASDE 228
Query: 257 ASYVTGAVLVADGG 270
++YVTG ++ DGG
Sbjct: 229 SAYVTGNPVIIDGG 242
>gi|126723750 dehydrogenase/reductase (SDR family) member 4 like 1
[Homo sapiens]
Length = 281
Score = 68.9 bits (167), Expect = 5e-12
Identities = 71/255 (27%), Positives = 106/255 (41%), Gaps = 14/255 (5%)
Query: 24 DLLRDKVAFITGGGSGIGFRIAEIFMRHGCHTVIASRSLPRVLTAARKLAG----ATGRR 79
D L +KVA +T IGF +A+ + G H V++ R V A L G TG
Sbjct: 28 DPLTNKVALVTASTDWIGFAVAQRLAQDGAHVVVSRRKQQNVDQAVATLQGEGLSMTGTV 87
Query: 80 CLPLSMDVRAPPAVMAAVDQALKEFGRIDIL----INCAAGNFLCPAGALSFNAFKTVMD 135
C V V A+K G IDIL N G F + A+ +D
Sbjct: 88 C-----HVGKMKDWERLVATAMKLHGVIDILSLSITNSKRGLFWFTLLQTAEEAWDRNLD 142
Query: 136 IDTSGTFNVSRVLYEKFFRDHGGVIVNITATLGNRGQALQVHAGSAKAAVDAMTRHLAVE 195
I+ + + + + + GG + + + R +K A+ + + LA+E
Sbjct: 143 INGKALALMIKAVVPEMEKRGGGSVGFLASVAAFRPLPGFSPYNVSKTALLGLNKTLAIE 202
Query: 196 WGPQNIRVNSLAPGPISGTEGLRRLGGPQASLSTKVTASPLQRLGNKTEIAHSVLYLASP 255
P+NIRVN LAPG I T R L + + ++RLG + V +L S
Sbjct: 203 LAPRNIRVNCLAPGLIK-TSFSRMLWMDKEKEESMKETLRIRRLGEPEDSLGIVSFLCSE 261
Query: 256 LASYVTGAVLVADGG 270
ASY+TG ++ GG
Sbjct: 262 DASYLTGETVMVGGG 276
>gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo
sapiens]
Length = 339
Score = 62.8 bits (151), Expect = 3e-10
Identities = 49/190 (25%), Positives = 87/190 (45%), Gaps = 4/190 (2%)
Query: 26 LRDKVAFITGGGSGIGFRIAEIFMRHGCHTVIASR---SLPRVLTAARKLAGATGRRCLP 82
L D V ++TG SGIG +A + G V+++R L RV + + L
Sbjct: 48 LTDMVVWVTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLKEKDILV 107
Query: 83 LSMDVRAPPAVMAAVDQALKEFGRIDILINCAAGNFLCPAGALSFNAFKTVMDIDTSGTF 142
L +D+ + AA L+EFGRIDIL+N + S + ++ +++++ GT
Sbjct: 108 LPLDLTDTGSHEAATKAVLQEFGRIDILVNNGGMSQRSLCMDTSLDVYRKLIELNYLGTV 167
Query: 143 NVSRVLYEKFFRDHGGVIVNITATLGNRGQALQVHAGSAKAAVDAMTRHLAVEWGP-QNI 201
++++ + G IV + + LG L + ++K A+ L E I
Sbjct: 168 SLTKCVLPHMIERKQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRTELATYPGI 227
Query: 202 RVNSLAPGPI 211
V+++ PGP+
Sbjct: 228 IVSNICPGPV 237
>gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo
sapiens]
Length = 325
Score = 62.4 bits (150), Expect = 5e-10
Identities = 53/192 (27%), Positives = 87/192 (45%), Gaps = 7/192 (3%)
Query: 26 LRDKVAFITGGGSGIGFRIAEIFMRHGCHTVIASRS------LPRVLTAARKLAGATGRR 79
LR+ V ITG SG+G A++F G V+ R+ L R LTA+ T +
Sbjct: 50 LRNAVVVITGATSGLGKECAKVFYAAGAKLVLCGRNGGALEELIRELTASHATKVQTHKP 109
Query: 80 CLPLSMDVRAPPAVMAAVDQALKEFGRIDILINCAAGNFLCPAGALSFNAFKTVMDIDTS 139
L ++ D+ A++AA + L+ FG +DIL+N A ++ + + K VM+ +
Sbjct: 110 YL-VTFDLTDSGAIVAAAAEILQCFGYVDILVNNAGISYRGTIMDTTVDVDKRVMETNYF 168
Query: 140 GTFNVSRVLYEKFFRDHGGVIVNITATLGNRGQALQVHAGSAKAAVDAMTRHLAVEWGPQ 199
G +++ L + G IV I++ G + ++K A A L E
Sbjct: 169 GPVALTKALLPSMIKRRQGHIVAISSIQGKMSIPFRSAYAASKHATQAFFDCLRAEMEQY 228
Query: 200 NIRVNSLAPGPI 211
I V ++PG I
Sbjct: 229 EIEVTVISPGYI 240
>gi|126723191 dehydrogenase/reductase (SDR family) member 4 like 2
[Homo sapiens]
Length = 232
Score = 58.2 bits (139), Expect = 9e-09
Identities = 53/188 (28%), Positives = 82/188 (43%), Gaps = 10/188 (5%)
Query: 24 DLLRDKVAFITGGGSGIGFRIAEIFMRHGCHTVIASRSLPRVLTAARKLAG----ATGRR 79
D L +KVA +T GIGF IA + H V++SR V A L G TG
Sbjct: 28 DPLTNKVALVTASTDGIGFAIARRLAQDRAHVVVSSRKQQNVDQAVATLQGEGLSVTGTV 87
Query: 80 CLPLSMDVRAPPAVMAAVDQALKEFGRIDILINCAAGN-FLCPAGALSFNAFKTVMDIDT 138
C + R V A+K G IDIL++ AA N F ++ + +DI+
Sbjct: 88 CHVGKAEDRE-----RLVAMAVKLHGGIDILVSNAAVNPFFGSLMDVTEEVWDKTLDINV 142
Query: 139 SGTFNVSRVLYEKFFRDHGGVIVNITATLGNRGQALQVHAGSAKAAVDAMTRHLAVEWGP 198
+++ + + + GG +V +++ +K A+ + LA+E P
Sbjct: 143 KAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLNNTLAIELAP 202
Query: 199 QNIRVNSL 206
+NIRVN L
Sbjct: 203 RNIRVNCL 210
>gi|4504505 hydroxysteroid (17-beta) dehydrogenase 4 [Homo sapiens]
Length = 736
Score = 57.0 bits (136), Expect = 2e-08
Identities = 50/193 (25%), Positives = 80/193 (41%), Gaps = 21/193 (10%)
Query: 29 KVAFITGGGSGIGFRIAEIFMRHGCHTVIAS-----RSLPRVLTAARKLAGATGRRCLPL 83
+V +TG G+G+G A F G V+ + + + AA K+ RR
Sbjct: 10 RVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSLAADKVVEEIRRRGGKA 69
Query: 84 SMDVRAPPAVMAAVDQALKEFGRIDILINCAAGNFLCPAGALSFNAFKTVMDIDTS---- 139
+ + V AL FGRID+++N AG L +F + D D
Sbjct: 70 VANYDSVEEGEKVVKTALDAFGRIDVVVN--------NAGILRDRSFARISDEDWDIIHR 121
Query: 140 ----GTFNVSRVLYEKFFRDHGGVIVNITATLGNRGQALQVHAGSAKAAVDAMTRHLAVE 195
G+F V+R +E + G I+ ++ G G Q + +AK + + LA+E
Sbjct: 122 VHLRGSFQVTRAAWEHMKKQKYGRIIMTSSASGIYGNFGQANYSAAKLGLLGLANSLAIE 181
Query: 196 WGPQNIRVNSLAP 208
NI N++AP
Sbjct: 182 GRKSNIHCNTIAP 194
>gi|223718074 hydroxysteroid (17-beta) dehydrogenase 1 [Homo
sapiens]
Length = 328
Score = 56.2 bits (134), Expect = 3e-08
Identities = 52/203 (25%), Positives = 86/203 (42%), Gaps = 7/203 (3%)
Query: 30 VAFITGGGSGIGFRIAEIFMRHGCHTVIASRSLPRVLTAARKLAGATGRRCLP-----LS 84
V ITG SGIG +A + +L + T R A C P L
Sbjct: 5 VVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQ 64
Query: 85 MDVRAPPAVMAAVDQALKEFGRIDILINCAAGNFLCPAGALSFNAFKTVMDIDTSGTFNV 144
+DVR +V AA ++ + GR+D+L+ A L P AL +A +V+D++ GT +
Sbjct: 65 LDVRDSKSVAAARERVTE--GRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRM 122
Query: 145 SRVLYEKFFRDHGGVIVNITATLGNRGQALQVHAGSAKAAVDAMTRHLAVEWGPQNIRVN 204
+ R G ++ + G G ++K A++ + LAV P + ++
Sbjct: 123 LQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVHLS 182
Query: 205 SLAPGPISGTEGLRRLGGPQASL 227
+ GP+ + LG P+ L
Sbjct: 183 LIECGPVHTAFMEKVLGSPEEVL 205
>gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens]
Length = 331
Score = 52.8 bits (125), Expect = 4e-07
Identities = 56/231 (24%), Positives = 100/231 (43%), Gaps = 20/231 (8%)
Query: 22 CPD--LLRDKVAFITGGGSGIGFRIAEIFMRHGCHTVIASRSLPRVLTAARKLAGAT-GR 78
CP + K +TG +GIG + A R G + ++A R + + AA+ + G T
Sbjct: 30 CPSKATIPGKTVIVTGANTGIGKQTALELARRGGNIILACRDMEKCEAAAKDIRGETLNH 89
Query: 79 RCLPLSMDVRAPPAVMAAVDQALKEFGRIDILINCAAGNFLCPAGALSFNAFKTVMDIDT 138
+D+ + ++ + ++E R+DILIN AG CP + F+ ++
Sbjct: 90 HVNARHLDLASLKSIREFAAKIIEEEERVDILIN-NAGVMRCPHWTTE-DGFEMQFGVNH 147
Query: 139 SGTFNVSRVLYEKFFRDHGGVIVNITATLGNRG---------QALQVHAGSA----KAAV 185
G F ++ +L +K I+N+++ G Q + + +A K A+
Sbjct: 148 LGHFLLTNLLLDKLKASAPSRIINLSSLAHVAGHIDFDDLNWQTRKYNTKAAYCQSKLAI 207
Query: 186 DAMTRHLAVEWGPQNIRVNSLAPGPISGTEGLRRLGGPQASLSTKVTASPL 236
T+ L+ + VN+L PG ++ TE L R G S + T P+
Sbjct: 208 VLFTKELSRRLQGSGVTVNALHPG-VARTE-LGRHTGIHGSTFSSTTLGPI 256
>gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo
sapiens]
Length = 332
Score = 52.8 bits (125), Expect = 4e-07
Identities = 48/188 (25%), Positives = 85/188 (45%), Gaps = 5/188 (2%)
Query: 33 ITGGGSGIGFRIAEIFMRHGCHTVIASRSLPRVLTAARKLAGAT---GRRCLPLSMDVRA 89
+TGG SGIG IA + G + +R+ ++L A +++ + + L +S+DV
Sbjct: 37 VTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKEIEMHSINDKQVVLCISVDVSQ 96
Query: 90 P-PAVMAAVDQALKEFGRIDILINCAAGNFLCPAGALSFNAFKTVMDIDTSGTFNVSRVL 148
V + QA ++ G +D+L+NCA L + F+ +M I+ G+ SR +
Sbjct: 97 DYNQVENVIKQAQEKLGPVDMLVNCAGMAVSGKFEDLEVSTFERLMSINYLGSVYPSRAV 156
Query: 149 YEKFFRDHGGVIVNITATLGNRGQALQVHAGSAKAAVDAMTRHLAVEWGPQNIRVNSLAP 208
G IV +++ G G ++K A+ + L +E P N+ + P
Sbjct: 157 ITTMKERRVGRIVFVSSQAGQLGLFGFTAYSASKFAIRGLAEALQMEVKPYNVYITVAYP 216
Query: 209 GPISGTEG 216
P + T G
Sbjct: 217 -PDTDTPG 223
>gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens]
Length = 311
Score = 52.0 bits (123), Expect = 6e-07
Identities = 45/187 (24%), Positives = 79/187 (42%), Gaps = 8/187 (4%)
Query: 29 KVAFITGGGSGIGFRIAEIFMRHG----CHTVIASRSLPRVLTAARKLAGATGRRCLPLS 84
+ I+G SGIG +A + + H V R L + T A G+
Sbjct: 6 RTVLISGCSSGIGLELA-VQLAHDPKKRYQVVATMRDLGKKETLEAAAGEALGQTLTVAQ 64
Query: 85 MDVRAPPAVMAAVDQALKEFGRIDILINCAAGNFLCPAGALSFNAFKTVMDIDTSGTFNV 144
+DV + +V + G +D+L+N A + P LS A + V D + G +
Sbjct: 65 LDVCSDESVAQCLSCIQ---GEVDVLVNNAGMGLVGPLEGLSLAAMQNVFDTNFFGAVRL 121
Query: 145 SRVLYEKFFRDHGGVIVNITATLGNRGQALQVHAGSAKAAVDAMTRHLAVEWGPQNIRVN 204
+ + R G IV I++ +G +G ++K A++ LA++ NI ++
Sbjct: 122 VKAVLPGMKRRRQGHIVVISSVMGLQGVIFNDVYAASKFALEGFFESLAIQLLQFNIFIS 181
Query: 205 SLAPGPI 211
+ PGP+
Sbjct: 182 LVEPGPV 188
>gi|150247226 retinol dehydrogenase 16 [Homo sapiens]
Length = 317
Score = 50.1 bits (118), Expect = 2e-06
Identities = 50/190 (26%), Positives = 83/190 (43%), Gaps = 15/190 (7%)
Query: 26 LRDKVAFITGGGSGIGFRIAEIFMRHGCHTVIASRSLPRVLTAARKLAGATGRRCLPLSM 85
LRDK FITG SG G +A G + A + A +L G T R +++
Sbjct: 27 LRDKYVFITGCDSGFGKLLARQLDARGLRVLAACLT----EKGAEQLRGQTSDRLETVTL 82
Query: 86 DVRAPPAVMAA---VDQALKEFGRIDILINCAAGNFLCPAGALSFNAFKTVMDIDTSGTF 142
DV +V AA V + +++ G ++ N P L+ F T++D++ G
Sbjct: 83 DVTKTESVAAAAQWVKECVRDKGLWGLVNNAGISLPTAPNELLTKQDFVTILDVNLLGVI 142
Query: 143 NVSRVLYEKFFRDHGGVIVNITATLGNRGQALQVHAGS---AKAAVDAMTRHLAVEWGPQ 199
+V+ L R G V VN+++ +G + + G +K V+A + L E
Sbjct: 143 DVTLSLLPLVRRARGRV-VNVSSVMGR----VSLFGGGYCISKYGVEAFSDSLRRELSYF 197
Query: 200 NIRVNSLAPG 209
++V + PG
Sbjct: 198 GVKVAMIEPG 207
>gi|38424085 short-chain dehydrogenase/reductase 10 isoform b [Homo
sapiens]
Length = 286
Score = 49.7 bits (117), Expect = 3e-06
Identities = 54/223 (24%), Positives = 94/223 (42%), Gaps = 20/223 (8%)
Query: 21 FCPDLLRDKVAFITGGGSGIGFRIAEIFMRHGCHTVIASRS---LPRVLTAARKLAGATG 77
F P L+ +TG +G+G +A + R G H V+ + + L +V+ RKL
Sbjct: 22 FDPASLQGARVLLTGANAGVGEELAYHYARLGSHLVLTAHTEALLQKVVGNCRKLGAP-- 79
Query: 78 RRCLPLSMDVRAPPAVMAAVDQALKEFGRIDILINCAAGNFLCPAGALSFNAFKTVMDID 137
+ ++ D+ +P A + V AL + G +D L+ G A S A + +M ++
Sbjct: 80 -KVFYIAADMASPEAPESVVQFALDKLGGLDYLVLNHIGGAPAGTRARSPQATRWLMQVN 138
Query: 138 -TSGTFNVSRVLYEKFFRDHGGVIVNITATLGNRGQALQVHAGSAKAAVDAMTRHLAVEW 196
S SR L D G +V +++ LG + +AK A+D L E
Sbjct: 139 FVSYVQLTSRAL--PSLTDSKGSLVVVSSLLGRVPTSFSTPYSAAKFALDGFFGSLRREL 196
Query: 197 GPQNIRV-----------NSLAPGPISGTEGLRRLGGPQASLS 228
Q++ V + A + G ++ GP+A+L+
Sbjct: 197 DVQDVNVAITMCVLGLRDRASAAEAVRGVTRVKAAPGPKAALA 239
>gi|4504503 hydroxysteroid (17-beta) dehydrogenase 2 [Homo sapiens]
Length = 387
Score = 49.3 bits (116), Expect = 4e-06
Identities = 53/206 (25%), Positives = 82/206 (39%), Gaps = 16/206 (7%)
Query: 13 CLPAYRHLFCPDLLR--DKVAFITGGGSGIGFRIAEIFMRHGCHTVIASRSLPRVLTAAR 70
C Y +L +LL K +TGG G+G + + G TV A VL
Sbjct: 65 CFLMYTYLSGQELLPVDQKAVLVTGGDCGLGHALCKYLDELG-FTVFAG-----VLNENG 118
Query: 71 KLAGATGRRCLP----LSMDVRAPPAVMAAVDQA---LKEFGRIDILINCAAGNFLCPAG 123
A R C P L MD+ P + A + L++ G ++ N F
Sbjct: 119 PGAEELRRTCSPRLSVLQMDITKPVQIKDAYSKVAAMLQDRGLWAVINNAGVLGFPTDGE 178
Query: 124 ALSFNAFKTVMDIDTSGTFNVSRVLYEKFFRDHGGVIVNITATLGNRGQALQVHAGSAKA 183
L +K M ++ GT V++ + R G +VN+++ G GS+KA
Sbjct: 179 LLLMTDYKQCMAVNFFGTVEVTKT-FLPLLRKSKGRLVNVSSMGGGAPMERLASYGSSKA 237
Query: 184 AVDAMTRHLAVEWGPQNIRVNSLAPG 209
AV + + +E I+V S+ PG
Sbjct: 238 AVTMFSSVMRLELSKWGIKVASIQPG 263
>gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens]
Length = 260
Score = 48.9 bits (115), Expect = 5e-06
Identities = 51/193 (26%), Positives = 86/193 (44%), Gaps = 9/193 (4%)
Query: 27 RDKVAFITGGGSGIGFRIAEIFMRHGCHTVIASRSLPRV--LTAARKLAGATGRRCLPLS 84
RD++A +TG GIG +A ++ G V +R++ + L A K AG G +P
Sbjct: 10 RDRLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKSAGYPG-TLIPYR 68
Query: 85 MDVRAPPAVMAAVDQALKEFGRIDILINCAAGNFLCPAGALSFNAFKTVMDIDTSGTFNV 144
D+ +++ + +DI IN A + S + +K + +++
Sbjct: 69 CDLSNEEDILSMFSAIRSQHSGVDICINNAGLARPDTLLSGSTSGWKDMFNVNVLALSIC 128
Query: 145 SRVLYEKFFRDH--GGVIVNITATLGNRGQALQV-HAGSA-KAAVDAMTRHLAVEW--GP 198
+R Y+ + G I+NI + G+R L V H SA K AV A+T L E
Sbjct: 129 TREAYQSMKERNVDDGHIININSMSGHRVLPLSVTHFYSATKYAVTALTEGLRQELREAQ 188
Query: 199 QNIRVNSLAPGPI 211
+IR ++PG +
Sbjct: 189 THIRATCISPGVV 201
>gi|166795268 retinol dehydrogenase 11 [Homo sapiens]
Length = 318
Score = 48.1 bits (113), Expect = 9e-06
Identities = 37/148 (25%), Positives = 70/148 (47%), Gaps = 3/148 (2%)
Query: 26 LRDKVAFITGGGSGIGFRIAEIFMRHGCHTVIASRSLPRVLTAARKLAGATG-RRCLPLS 84
L KV +TG +GIG A+ + G +A R + + A+++ TG ++ L
Sbjct: 39 LPGKVVVVTGANTGIGKETAKELAQRGARVYLACRDVEKGELVAKEIQTTTGNQQVLVRK 98
Query: 85 MDVRAPPAVMAAVDQALKEFGRIDILINCAAGNFLCPAGALSFNAFKTVMDIDTSGTFNV 144
+D+ ++ A L E + +LIN AG +CP + + F+ + ++ G F +
Sbjct: 99 LDLSDTKSIRAFAKGFLAEEKHLHVLIN-NAGVMMCPYSKTA-DGFEMHIGVNHLGHFLL 156
Query: 145 SRVLYEKFFRDHGGVIVNITATLGNRGQ 172
+ +L EK IVN+++ + G+
Sbjct: 157 THLLLEKLKESAPSRIVNVSSLAHHLGR 184
>gi|157739938 dehydrogenase/reductase (SDR family) member 7C [Homo
sapiens]
Length = 311
Score = 47.8 bits (112), Expect = 1e-05
Identities = 50/215 (23%), Positives = 86/215 (40%), Gaps = 10/215 (4%)
Query: 20 LFCPDLLRDKVAFITGGGSGIGFRIAEIFMRHGCHTVIASRSLPRV-------LTAARKL 72
L+ +++KV IT SG+G A +F G V+ ++ R+ ++ A
Sbjct: 29 LWSKSAVQNKVVVITDAISGLGKECARVFHTGGARLVLCGKNWERLENLYDALISVADPS 88
Query: 73 AGATGRRCLPLSMDVRAPPAVMAAVDQALKEFGRIDILINCAAGNFLCPAGALSFNAFKT 132
T + L D+ P V V L +G +DILIN A+ PA +S K
Sbjct: 89 KTFTPKLVLLDLSDISCVPDVAKEV---LDCYGCVDILINNASVKVKGPAHKISLELDKK 145
Query: 133 VMDIDTSGTFNVSRVLYEKFFRDHGGVIVNITATLGNRGQALQVHAGSAKAAVDAMTRHL 192
+MD + G +++ L G IV + G G + ++K A L
Sbjct: 146 IMDANYFGPITLTKALLPNMISRRTGQIVLVNNIQGKFGIPFRTTYAASKHAALGFFDCL 205
Query: 193 AVEWGPQNIRVNSLAPGPISGTEGLRRLGGPQASL 227
E ++ +++++P I G +AS+
Sbjct: 206 RAEVEEYDVVISTVSPTFIRSYHVYPEQGNWEASI 240
>gi|38348362 short-chain dehydrogenase/reductase 10 isoform e [Homo
sapiens]
Length = 315
Score = 47.8 bits (112), Expect = 1e-05
Identities = 48/187 (25%), Positives = 81/187 (43%), Gaps = 9/187 (4%)
Query: 21 FCPDLLRDKVAFITGGGSGIGFRIAEIFMRHGCHTVIASRS---LPRVLTAARKLAGATG 77
F P L+ +TG +G+G +A + R G H V+ + + L +V+ RKL
Sbjct: 22 FDPASLQGARVLLTGANAGVGEELAYHYARLGSHLVLTAHTEALLQKVVGNCRKLGAP-- 79
Query: 78 RRCLPLSMDVRAPPAVMAAVDQALKEFGRIDILINCAAGNFLCPAGALSFNAFKTVMDID 137
+ ++ D+ +P A + V AL + G +D L+ G A S A + +M ++
Sbjct: 80 -KVFYIAADMASPEAPESVVQFALDKLGGLDYLVLNHIGGAPAGTRARSPQATRWLMQVN 138
Query: 138 -TSGTFNVSRVLYEKFFRDHGGVIVNITATLGNRGQALQVHAGSAKAAVDAMTRHLAVEW 196
S SR L D G +V +++ LG + +AK A+D L E
Sbjct: 139 FVSYVQLTSRAL--PSLTDSKGSLVVVSSLLGRVPTSFSTPYSAAKFALDGFFGSLRREL 196
Query: 197 GPQNIRV 203
Q++ V
Sbjct: 197 DVQDVNV 203
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.137 0.416
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,413,278
Number of Sequences: 37866
Number of extensions: 480768
Number of successful extensions: 1156
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 43
Number of HSP's successfully gapped in prelim test: 22
Number of HSP's that attempted gapping in prelim test: 1061
Number of HSP's gapped (non-prelim): 67
length of query: 292
length of database: 18,247,518
effective HSP length: 101
effective length of query: 191
effective length of database: 14,423,052
effective search space: 2754802932
effective search space used: 2754802932
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.