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Search of human proteins with 100814339
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|100814339 coiled-coil domain containing 146 [Homo sapiens]
(955 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|100814339 coiled-coil domain containing 146 [Homo sapiens] 1842 0.0
gi|56961680 coiled-coil domain containing 147 [Homo sapiens] 182 2e-45
gi|56550047 uveal autoantigen with coiled-coil domains and ankyr... 116 1e-25
gi|59850762 uveal autoantigen with coiled-coil domains and ankyr... 116 1e-25
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 115 3e-25
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 115 3e-25
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 115 3e-25
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 115 3e-25
gi|55770834 centromere protein F [Homo sapiens] 115 3e-25
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 114 4e-25
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 113 7e-25
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 113 7e-25
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 112 2e-24
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 111 4e-24
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 109 1e-23
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 107 4e-23
gi|21735548 centrosomal protein 2 [Homo sapiens] 107 4e-23
gi|71061468 centromere protein E [Homo sapiens] 107 5e-23
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 107 7e-23
gi|32698688 citron [Homo sapiens] 106 9e-23
gi|154354990 ankyrin repeat domain 26 [Homo sapiens] 106 1e-22
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 105 2e-22
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 105 2e-22
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 103 1e-21
gi|156104908 myosin heavy chain 6 [Homo sapiens] 102 2e-21
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 101 4e-21
gi|118498356 kinectin 1 isoform a [Homo sapiens] 100 5e-21
gi|33620775 kinectin 1 isoform a [Homo sapiens] 100 5e-21
gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens] 100 6e-21
gi|148746195 trichohyalin [Homo sapiens] 100 6e-21
>gi|100814339 coiled-coil domain containing 146 [Homo sapiens]
Length = 955
Score = 1842 bits (4770), Expect = 0.0
Identities = 955/955 (100%), Positives = 955/955 (100%)
Query: 1 MEDSSTDTEKEEEEEKDEKDQEPIYAIVPTINIQDERFVDLSETPAFIFLHELHAMGKLP 60
MEDSSTDTEKEEEEEKDEKDQEPIYAIVPTINIQDERFVDLSETPAFIFLHELHAMGKLP
Sbjct: 1 MEDSSTDTEKEEEEEKDEKDQEPIYAIVPTINIQDERFVDLSETPAFIFLHELHAMGKLP 60
Query: 61 GTRMAALKAKYTLLHDAVMSTQESEVQLLQNAKRFTEQIQQQQFHLQQADNFPEAFSTEV 120
GTRMAALKAKYTLLHDAVMSTQESEVQLLQNAKRFTEQIQQQQFHLQQADNFPEAFSTEV
Sbjct: 61 GTRMAALKAKYTLLHDAVMSTQESEVQLLQNAKRFTEQIQQQQFHLQQADNFPEAFSTEV 120
Query: 121 SKMREQLLKYQNEYNAVKEREFHNQYRLNSLKEEKIIIVKEFEKITKPGEMEKKMKILRE 180
SKMREQLLKYQNEYNAVKEREFHNQYRLNSLKEEKIIIVKEFEKITKPGEMEKKMKILRE
Sbjct: 121 SKMREQLLKYQNEYNAVKEREFHNQYRLNSLKEEKIIIVKEFEKITKPGEMEKKMKILRE 180
Query: 181 STEELRKEIMQKKLEIKNLREDLASKQKQLLKEQKELEELLGHQVVLKDEVAHHQTIPVQ 240
STEELRKEIMQKKLEIKNLREDLASKQKQLLKEQKELEELLGHQVVLKDEVAHHQTIPVQ
Sbjct: 181 STEELRKEIMQKKLEIKNLREDLASKQKQLLKEQKELEELLGHQVVLKDEVAHHQTIPVQ 240
Query: 241 IGKEIEKITRKKVEMEKKKIVLEQEVKTLNDSLKKVENKVSAIVDEKENVIKEVEGKRAL 300
IGKEIEKITRKKVEMEKKKIVLEQEVKTLNDSLKKVENKVSAIVDEKENVIKEVEGKRAL
Sbjct: 241 IGKEIEKITRKKVEMEKKKIVLEQEVKTLNDSLKKVENKVSAIVDEKENVIKEVEGKRAL 300
Query: 301 LEIKEREHNQLVKLLELARENEATSLTERGILDLNLRNSLIDKQNYHDELSRKQREKERD 360
LEIKEREHNQLVKLLELARENEATSLTERGILDLNLRNSLIDKQNYHDELSRKQREKERD
Sbjct: 301 LEIKEREHNQLVKLLELARENEATSLTERGILDLNLRNSLIDKQNYHDELSRKQREKERD 360
Query: 361 FRNLRKMELLLKVSWDALRQTQALHQRLLLEMEAIPKDDSTLSERRRELHKEVEVAKRNL 420
FRNLRKMELLLKVSWDALRQTQALHQRLLLEMEAIPKDDSTLSERRRELHKEVEVAKRNL
Sbjct: 361 FRNLRKMELLLKVSWDALRQTQALHQRLLLEMEAIPKDDSTLSERRRELHKEVEVAKRNL 420
Query: 421 AQQKIISEMESKLVEQQLAEENKLLKEQENMKELVVNLLRMTQIKIDEKEQKSKDFLKAQ 480
AQQKIISEMESKLVEQQLAEENKLLKEQENMKELVVNLLRMTQIKIDEKEQKSKDFLKAQ
Sbjct: 421 AQQKIISEMESKLVEQQLAEENKLLKEQENMKELVVNLLRMTQIKIDEKEQKSKDFLKAQ 480
Query: 481 QKYTNIVKEMKAKDLEIRIHKKKKCEIYRRLREFAKLYDTIRNERNKFVNLLHKAHQKVN 540
QKYTNIVKEMKAKDLEIRIHKKKKCEIYRRLREFAKLYDTIRNERNKFVNLLHKAHQKVN
Sbjct: 481 QKYTNIVKEMKAKDLEIRIHKKKKCEIYRRLREFAKLYDTIRNERNKFVNLLHKAHQKVN 540
Query: 541 EIKERHKMSLNELEILRNSAVSQERKLQNSMLKHANNVTIRESMQNDVRKIVSKLQEMKE 600
EIKERHKMSLNELEILRNSAVSQERKLQNSMLKHANNVTIRESMQNDVRKIVSKLQEMKE
Sbjct: 541 EIKERHKMSLNELEILRNSAVSQERKLQNSMLKHANNVTIRESMQNDVRKIVSKLQEMKE 600
Query: 601 KKEAQLNNIDRLANTITMIEEEMVQLRKRYEKAVQHRNESGVQLIEREEEICIFYEKINI 660
KKEAQLNNIDRLANTITMIEEEMVQLRKRYEKAVQHRNESGVQLIEREEEICIFYEKINI
Sbjct: 601 KKEAQLNNIDRLANTITMIEEEMVQLRKRYEKAVQHRNESGVQLIEREEEICIFYEKINI 660
Query: 661 QEKMKLNGEIEIHLLEEKIQFLKMKIAEKQRQICVTQKLLPAKRSLDADLAVLQIQFSQC 720
QEKMKLNGEIEIHLLEEKIQFLKMKIAEKQRQICVTQKLLPAKRSLDADLAVLQIQFSQC
Sbjct: 661 QEKMKLNGEIEIHLLEEKIQFLKMKIAEKQRQICVTQKLLPAKRSLDADLAVLQIQFSQC 720
Query: 721 TDRIKDLEKQFVKPDGENRARFLPGKDLTEKEMIQKLDKLELQLAKKEEKLLEKDFIYEQ 780
TDRIKDLEKQFVKPDGENRARFLPGKDLTEKEMIQKLDKLELQLAKKEEKLLEKDFIYEQ
Sbjct: 721 TDRIKDLEKQFVKPDGENRARFLPGKDLTEKEMIQKLDKLELQLAKKEEKLLEKDFIYEQ 780
Query: 781 VSRLTDRLCSKTQGCKQDTLLLAKKMNGYQRRIKNATEKMMALVAELSMKQALTIELQKE 840
VSRLTDRLCSKTQGCKQDTLLLAKKMNGYQRRIKNATEKMMALVAELSMKQALTIELQKE
Sbjct: 781 VSRLTDRLCSKTQGCKQDTLLLAKKMNGYQRRIKNATEKMMALVAELSMKQALTIELQKE 840
Query: 841 VREKEDFIFTCNSRIEKGLPLNKEIEKEWLKVLRDEEMHALAIAEKSQEFLEADNRQLPN 900
VREKEDFIFTCNSRIEKGLPLNKEIEKEWLKVLRDEEMHALAIAEKSQEFLEADNRQLPN
Sbjct: 841 VREKEDFIFTCNSRIEKGLPLNKEIEKEWLKVLRDEEMHALAIAEKSQEFLEADNRQLPN 900
Query: 901 GVYTTAEQRPNAYIPEADATLPLPKPYGALAPFKPSEPGANMRHIRKPVIKPVEI 955
GVYTTAEQRPNAYIPEADATLPLPKPYGALAPFKPSEPGANMRHIRKPVIKPVEI
Sbjct: 901 GVYTTAEQRPNAYIPEADATLPLPKPYGALAPFKPSEPGANMRHIRKPVIKPVEI 955
>gi|56961680 coiled-coil domain containing 147 [Homo sapiens]
Length = 872
Score = 182 bits (461), Expect = 2e-45
Identities = 178/871 (20%), Positives = 397/871 (45%), Gaps = 61/871 (7%)
Query: 50 LHELHAMGKLPGTRMAALKAKYTLLHDAVMSTQESEVQLLQNAKRFTEQIQQQQFHLQQA 109
LHEL L R+ +Y LH + + ++E +L+ + +I + A
Sbjct: 27 LHELSGDKSLEKFRI-----EYERLHAVMKKSYDNEKRLMAKCRELNAEIVVNSAKVATA 81
Query: 110 DNFPEAFSTEVSKMREQLLKYQNEYNAVKEREFHNQYRLNSLKEEKIIIVKEFEKITKPG 169
+ T ++ +++++ K ++ ++E + + +LKEE + + K E+ +
Sbjct: 82 LKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKAKETILALKEEIVNLTKLVEQGSGLS 141
Query: 170 -EMEKKMKILRESTEELRKEIMQKKLEIKNLREDLASKQKQLLKEQKELEELLGHQVVLK 228
+ ++ L EE+ KE Q E+ LRE LA +Q + ++ EE +
Sbjct: 142 MDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQQETERSKEEAEHAISQFQ 201
Query: 229 DEVAHHQTIPVQIGKEIEKITRKKVEMEKKKIVLEQEVKTLNDSLKKVENKVSAIVDEKE 288
E+ Q E + RKK ++EK+ ++ ++ + +K ++ V +E +
Sbjct: 202 QEIQQRQN-------EASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQ 254
Query: 289 NVIKEVEGKRALLEIKEREHNQL-VKLLELARENEATSLTERGILDLNLRNSLIDKQNYH 347
+ ++++ ++ L E +E Q ++ +L +ENE SL + N + +L
Sbjct: 255 KLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKAL------- 307
Query: 348 DELSRKQREKERDFRNLRKMELLLKVSWDALRQTQ------ALHQRLLL--------EME 393
EL K+ E + ++ K+ + + L T+ H+ L E+E
Sbjct: 308 -ELKAKEEEVHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVGLEREVE 366
Query: 394 AIPKDDSTLSERRRELHKEVEVAKRNLAQQKIISEMESKLVEQQLAEENKLLKEQENMKE 453
A K + EL +E ++ +N+ + ++ ++ LV+ + L E +N K+
Sbjct: 367 ASKKQAELDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGEIQNYKD 426
Query: 454 LVVNLLRMTQIKIDEKEQKSKDFLKAQQKYTNIVKEMKAKDLEIRIHKKKKCEIYRRLRE 513
++ E+++ QK ++++K ++ +I ++KK E +L++
Sbjct: 427 EAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFDYRKKIAESEIKLKQ 486
Query: 514 FAKLYDTIRNERNKFVNLLHKAHQKVNEIKERHKMSLNELEILRNSAVSQERKLQNSMLK 573
LY+ +R++RN + L +A ++ ++K + K+ +++++ L+ ++E L L+
Sbjct: 487 QQNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKESALVKLHLE 546
Query: 574 HANNVTIRESMQNDVRKIVSKLQEMKEKKEAQLNNIDRLANTITMIEEEMVQLRKRYEKA 633
+E+++ +++K+ + E K E Q +L I + E ++ +K ++
Sbjct: 547 QQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQV 606
Query: 634 VQHRNESGVQLIEREEEICIFYEKINIQEKMKLNGEIEIHLLEEKIQFLKMKIAEKQRQI 693
+ R+ G QL+ R +E+ + YEKI IQ+ + GE + + E ++ L+++I + +R+
Sbjct: 607 ISERDILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYNQRLEDMRILRLEIKKLRREK 666
Query: 694 CVTQKLLPAKRSLDADLAVLQIQFSQCTDRIKDLEKQFVKPDGENRARFLPGKDLTEKEM 753
+ + + L + +Q + + R + LE++ P +R R L D E+
Sbjct: 667 GILARSMANVEELRQEFFHMQRELLKERTRCRALEEELENPLNVHRWRKLEASDPNAYEL 726
Query: 754 IQKLDKLELQLAKKEEKLLEKDFIYEQVSRLTDRLCSKTQGCKQDTLLLAKKMNGYQRRI 813
IQK+ L+ +L K E+++EK+ + ++ +L L K +Q A+++ Y+R +
Sbjct: 727 IQKIHTLQKRLISKTEEVVEKELLLQEKEKLYMEL--KHVLARQPGPEAAEQLKLYRRTL 784
Query: 814 KNATEKMMALVAELSMKQALTIELQKEVREKEDFIFTCNSRIEKGLPLNKEIEKEWLKVL 873
+ +++ L +EL+M + + E + EV + + + + ++K++L
Sbjct: 785 HDKKQQLKVLSSELNMYEVQSKEYKYEVEKLTNEL--------------QNLKKKYLAQK 830
Query: 874 RDEEMHALAIAEKSQEFLEADNRQL---PNG 901
R E++ +K+++ DN L PNG
Sbjct: 831 RKEQL------QKNKDTAPMDNTFLMVKPNG 855
>gi|56550047 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 2 [Homo sapiens]
Length = 1403
Score = 116 bits (290), Expect = 1e-25
Identities = 163/789 (20%), Positives = 333/789 (42%), Gaps = 125/789 (15%)
Query: 107 QQADNFPEAFSTEVSKMREQLLKYQNEYNAVKEREFHNQYRLNSLKEEKIIIVKEFEKIT 166
++ +N + S EV++ ++L++ + E+ + + LK E + + +
Sbjct: 617 EKFENMKSSLSNEVNEKAKKLVEMEREHEK-------SLSEIRQLKRELENVKAKLAQHV 669
Query: 167 KPGEMEKKMKILRESTEELRKEIMQKKLEIKNLREDLASK--QKQLLKEQKE--LEELLG 222
KP E E+ L + + EL K+I + L+ + L++++ +LLKEQ E+
Sbjct: 670 KPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKN 729
Query: 223 HQVVLK---DEVAHHQTIPVQIGKEI----EKITRKKVEMEKKKIVLEQEVKTLNDSLKK 275
H V LK D H I + +++ +K T KK+EMEK ++LE NDSL K
Sbjct: 730 HYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEK--LLLE------NDSLSK 781
Query: 276 VENKVSAIVDEKENVIKE--------VEGKRALLEIKEREHNQLVKLLELAREN------ 321
+++ + E KE VE K+ L E+K++ K+ L EN
Sbjct: 782 DVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKM 841
Query: 322 -----------EATSLTERGILDLNLRNSLIDKQNYHD---ELSRKQREKERDFRNLRKM 367
E +T L R L K+ + D E + + + E RNL
Sbjct: 842 MSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENT 901
Query: 368 ELLLKVSWDALRQTQALHQRLLLEMEAIPKDDSTLSERRRE-------LHKEVEVAKRNL 420
+ +K + +L + +A L M + ++ + R+ LH E++ K+ L
Sbjct: 902 QNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKEL 961
Query: 421 AQ-QKIISEMESKLVEQQLAEENKLLKEQENMKELVVNLLRMTQIKIDEKEQKSKDFLKA 479
Q+ I + +V + E E+E +K+ + + + +E ++ ++ K
Sbjct: 962 DTIQECIKVKYAPIVSFEECERKFKATEKE-LKDQLSEQTQKYSVSEEEVKKNKQENDKL 1020
Query: 480 QQKYTNIVKEMKAKDLEI-------RIHKKKKCEIYRRLREFAKLYDTIRNERNKFV--- 529
+++ + K+++ K + I R +K E+ ++L++ ++ Y ++N + K V
Sbjct: 1021 KKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEEN 1080
Query: 530 -----------NLLHKAHQKVNEIKERHKMSLNELEILRNSAVSQER------------- 565
NLL K H + +++ K +E L+ S +R
Sbjct: 1081 AKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLH 1140
Query: 566 ----KLQNSMLKHANNVTIRESMQNDVRKIVSKLQEMKEKKEAQLNNIDRLANTITMIEE 621
+NS + A ++ I+E+ + +V I + L+E +E+ + ++ + +L + + ++
Sbjct: 1141 QLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQ 1200
Query: 622 EMVQLRKR--------------YEKAVQHRNESGVQLIEREEEICIFYEKINIQEKMKLN 667
+ +L R E + NE L + EE+C E++ +K +++
Sbjct: 1201 ALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVC---EEVLHAKKKEIS 1257
Query: 668 GEIEIHLLEEKI-QFLKMKIAEKQRQICVTQKLLPAKRSLDADLAVLQIQFSQCTDRIKD 726
+ E LL I Q +K +K+R + +R + ++ + ++ T+ + D
Sbjct: 1258 AKDEKELLHFSIEQEIK---DQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLND 1314
Query: 727 LEKQFVKPDGENRARFLPGKDLTEKEMIQKLDKLELQLAKKEEKLLEKDFIYEQVSRL-T 785
+E+ +G ++ + G K Q +D L+ Q+ E++L + D +++V +
Sbjct: 1315 VERLKQALNGLSQLTYTSGN--PTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYR 1372
Query: 786 DRLCSKTQG 794
L S QG
Sbjct: 1373 THLLSAAQG 1381
Score = 88.2 bits (217), Expect = 3e-17
Identities = 185/877 (21%), Positives = 377/877 (42%), Gaps = 118/877 (13%)
Query: 80 STQESEV--QLLQNAKRFTEQIQQQQFHLQQ--ADNFPE--AFSTEVSKMRE----QLLK 129
S E+E+ + L+ + F E +Q + LQ A E A + E +++E Q+ +
Sbjct: 422 SYSENEILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQ 481
Query: 130 YQNEYNAVKEREFHNQYRLNSLKEEKIIIVKEFEKITKPGEMEKKMKILRESTEELRKEI 189
++ V++R + ++ ++ ++ + + + G TEEL+ ++
Sbjct: 482 LEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGN--------HRLTEELKDQL 533
Query: 190 MQKKLEIKNLREDLASKQKQLLKEQKELEELLGHQVVLKDEVAHHQTIPVQIGKEIEKIT 249
K++ + ++ + Q+ + + +EE + L +E Q E EK
Sbjct: 534 KDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKG 593
Query: 250 RKKVEMEKKKIVLEQEVKTLNDSLKKVENKVSAIVDE-----KENVIKEVEGKRALLEIK 304
RK EME + L ++ L+ +K EN S++ +E K+ V E E +++L EI+
Sbjct: 594 RKVTEMEGQAKELSAKL-ALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIR 652
Query: 305 ERE---HNQLVKLLELARENEATSLTER----------GILDLNLRNSLIDKQNYHDELS 351
+ + N KL + + E + R I +L L+N + K+ L
Sbjct: 653 QLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLD 712
Query: 352 RK-QREKERDFR-NLRKMELLLKVSWDALRQTQALHQRLLLEMEAIPKDDSTLSERRREL 409
K +E+ + ++ + LKVS D + A+ L ++ + + +E++ E+
Sbjct: 713 NKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQ---KYTEKKLEM 769
Query: 410 HKEVEVAKRNLAQQKIISEMESKLVEQQLAEENKLLKEQENMKELVVNLLRMTQIKIDEK 469
K + N + K +S +E+ V + E +++ + N+ EL L + + K E
Sbjct: 770 EK---LLLENDSLSKDVSRLETVFVPPE-KHEKEIIALKSNIVELKKQLSELKK-KCGED 824
Query: 470 EQKSKDFLKAQQKYTNIVKEMKAKDLEIRIHKKKK-------CEIYRRLREFAKLYDTIR 522
++K + TN+ K M + + ++ H++ K + R L + K ++ I
Sbjct: 825 QEK---IHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDIN 881
Query: 523 NE----RNKFVNLLHKAHQKVNEIKERHKMSLNELEILRNSAVSQERKLQNSMLKHANNV 578
E ++K L N+IK + +SL E E +S RK+Q+S N
Sbjct: 882 QEFVKIKDKNEILKRNLENTQNQIKAEY-ISLAEHEAKMSSLSQSMRKVQDS------NA 934
Query: 579 TIRESMQNDVRKIVSKLQEMKEKKEAQLNNIDRLANTITMIEEEMVQLRKRYEKAVQHRN 638
I + + +IV+ E+K AQ +D + I + +V + K
Sbjct: 935 EILANYRKGQEEIVTLHAEIK----AQKKELDTIQECIKVKYAPIVSFEECERKFKATEK 990
Query: 639 ESGVQLIEREEEICIFYEKI--NIQEKMKLNGEIEIHLLEEKIQFLKMKIAEKQRQICVT 696
E QL E+ ++ + E++ N QE KL + EI L++ ++ K + EK ++
Sbjct: 991 ELKDQLSEQTQKYSVSEEEVKKNKQENDKL--KKEIFTLQKDLRD-KTVLIEKSHEM--- 1044
Query: 697 QKLLPAKR-SLDADLAVLQIQFSQCTDRIKDLEKQFVKPDGENRARFLPGKDLTEK---- 751
++ L K L+ L L ++++ +K+++++ V+ + + + L ++L +K
Sbjct: 1045 ERALSRKTDELNKQLKDLSQKYTE----VKNVKEKLVEENAKQTSEILAVQNLLQKQHVP 1100
Query: 752 -EMIQKLDK-LELQLAKKEEKLLEKDFIYEQVSRLTDRLCSKTQGCKQDTLLLAKKMNGY 809
E ++ L K L + +E+L YE+ + +L + K ++ LA+ +
Sbjct: 1101 LEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHL--- 1157
Query: 810 QRRIKNATEKMMALVAELSMKQALTIELQKEVREKEDFIFTCNSRIEKGLPLNKEIE--K 867
+IK A EK + ++ + +REKE+ +++E+ L E++ K
Sbjct: 1158 --QIKEAFEKEVGII-------------KASLREKEE---ESQNKMEEVSKLQSEVQNTK 1199
Query: 868 EWLKVLRDEEMHALAIAEKSQEFLEAD----NRQLPN 900
+ LK L E+ L+ + ++ LE N +L N
Sbjct: 1200 QALKKLETREVVDLSKYKATKSDLETQISSLNEKLAN 1236
Score = 77.8 bits (190), Expect = 4e-14
Identities = 109/514 (21%), Positives = 223/514 (43%), Gaps = 76/514 (14%)
Query: 64 MAALKAKYTLLHDAVMSTQESEVQLLQNAKRFTEQIQQQQFHLQ----QADNFPEA---- 115
+A +AK + L ++ Q+S ++L N ++ E+I ++ + D E
Sbjct: 912 LAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVK 971
Query: 116 -------------FSTEVSKMREQLLKYQNEYNAVKEREFHNQYRLNSLKEEKIIIVKEF 162
F ++++QL + +Y+ +E N+ + LK+E + K+
Sbjct: 972 YAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDL 1031
Query: 163 EK----ITKPGEMEKKMKILRESTEELRKEIMQKKLEIKNLREDLASKQKQLLKEQKELE 218
I K EME+ + + + K++ QK E+KN++E L + K+
Sbjct: 1032 RDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVE------ENAKQTS 1085
Query: 219 ELLGHQVVLKDEVAHHQTIPVQIGKEIEKITRKKVEMEKKKIVLEQEVKTLNDSLKKVEN 278
E+L Q +L+ Q +P++ + ++K +E L++E+K++ +K
Sbjct: 1086 EILAVQNLLQ-----KQHVPLEQVEALKKSLNGTIEN------LKEELKSMQRCYEK--- 1131
Query: 279 KVSAIVDEKENVIKEVEGKRALLEIKEREHNQLVKLLELARENEATSLTERGILDLNLRN 338
E++ V K L ++ E + N V L E + EA E GI+ +LR
Sbjct: 1132 -------EQQTVTK-------LHQLLENQKNSSVPLAEHLQIKEAFE-KEVGIIKASLRE 1176
Query: 339 SLIDKQNYHDELSRKQREKERDFRNLRKMELLLKVSWDALRQTQALHQRLLLEMEAIPKD 398
+ QN +E+S+ Q E + + L+K+E V L + +A L ++ ++ +
Sbjct: 1177 KEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVD---LSKYKATKSDLETQISSLNEK 1233
Query: 399 DSTLSERRRELHKEVEVAKRNLAQQKIISEMESKLVEQQLAEENKLLKEQENMKELVVNL 458
+ L+ + E+ +EV AK+ ++I ++ E +L+ + +E K KE+ + K L
Sbjct: 1234 LANLNRKYEEVCEEVLHAKK----KEISAKDEKELLHFSIEQEIKDQKERCD-KSLTTIT 1288
Query: 459 LRMTQIKIDEKEQKSKDFLKAQQKYTNIVKEMKAKDLEIRIHKKKKCEIYRRLREFAKLY 518
+I+ K+ ++KD K T ++ +++ + + + ++L
Sbjct: 1289 ELQRRIQESAKQIEAKD-----NKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLI 1343
Query: 519 DTIRNERNKFVNLLHKA---HQKVNEIKERHKMS 549
DT++++ L A HQ+V I H +S
Sbjct: 1344 DTLQHQVKSLEQQLADADRQHQEVIAIYRTHLLS 1377
Score = 42.0 bits (97), Expect = 0.003
Identities = 72/402 (17%), Positives = 150/402 (37%), Gaps = 82/402 (20%)
Query: 530 NLLHKAHQKVNEIKERHKMSLNELEILRNSAVSQERKLQNS-----------MLKHANNV 578
NL H + + +R ++ +LEI + RK+Q L+ V
Sbjct: 263 NLTHMQDEVNVKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEV 322
Query: 579 TIRESMQNDVRKIVSKLQEMKEKKEAQLNNIDRLANTITMIEEEMVQLRKRYEKAVQHRN 638
+ + ++++ K+ S L +++ E L I+ L N E + +
Sbjct: 323 MVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHL-------------- 368
Query: 639 ESGVQLIEREEEICIFYEKINIQEKMKLNGEIEIHL------------LEEKIQFLKMKI 686
SG R+E++ + ++ + + + I H+ L + + + +I
Sbjct: 369 GSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEI 428
Query: 687 AEKQ----RQIC--VTQKLLPAKRSLDADLAVLQI--------------QFSQCTDRIKD 726
+K+ R C Q L + L +A + Q Q D +KD
Sbjct: 429 LKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKD 488
Query: 727 LEKQFVKPDG---ENRARFLPGKD------------LTE------KEMIQKLDKLELQLA 765
++K+ + +G + + FL K+ LTE K++ K + ++
Sbjct: 489 VQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVG 548
Query: 766 KKEEKLLEKDFIYEQVSRLTDRLCSKTQGCKQDTLLLAKKMNGYQRRIKNATEKMMALVA 825
K ++ + + I E+ R +L + + +++ + + R++ +M
Sbjct: 549 KLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKV----TEMEGQAK 604
Query: 826 ELSMKQALTIELQKEVREKEDFIFTCNSRIEKGLPLNKEIEK 867
ELS K AL+I +K K N + +K + + +E EK
Sbjct: 605 ELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEK 646
>gi|59850762 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 1 [Homo sapiens]
Length = 1416
Score = 116 bits (290), Expect = 1e-25
Identities = 163/789 (20%), Positives = 333/789 (42%), Gaps = 125/789 (15%)
Query: 107 QQADNFPEAFSTEVSKMREQLLKYQNEYNAVKEREFHNQYRLNSLKEEKIIIVKEFEKIT 166
++ +N + S EV++ ++L++ + E+ + + LK E + + +
Sbjct: 630 EKFENMKSSLSNEVNEKAKKLVEMEREHEK-------SLSEIRQLKRELENVKAKLAQHV 682
Query: 167 KPGEMEKKMKILRESTEELRKEIMQKKLEIKNLREDLASK--QKQLLKEQKE--LEELLG 222
KP E E+ L + + EL K+I + L+ + L++++ +LLKEQ E+
Sbjct: 683 KPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKN 742
Query: 223 HQVVLK---DEVAHHQTIPVQIGKEI----EKITRKKVEMEKKKIVLEQEVKTLNDSLKK 275
H V LK D H I + +++ +K T KK+EMEK ++LE NDSL K
Sbjct: 743 HYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEK--LLLE------NDSLSK 794
Query: 276 VENKVSAIVDEKENVIKE--------VEGKRALLEIKEREHNQLVKLLELAREN------ 321
+++ + E KE VE K+ L E+K++ K+ L EN
Sbjct: 795 DVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKM 854
Query: 322 -----------EATSLTERGILDLNLRNSLIDKQNYHD---ELSRKQREKERDFRNLRKM 367
E +T L R L K+ + D E + + + E RNL
Sbjct: 855 MSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENT 914
Query: 368 ELLLKVSWDALRQTQALHQRLLLEMEAIPKDDSTLSERRRE-------LHKEVEVAKRNL 420
+ +K + +L + +A L M + ++ + R+ LH E++ K+ L
Sbjct: 915 QNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKEL 974
Query: 421 AQ-QKIISEMESKLVEQQLAEENKLLKEQENMKELVVNLLRMTQIKIDEKEQKSKDFLKA 479
Q+ I + +V + E E+E +K+ + + + +E ++ ++ K
Sbjct: 975 DTIQECIKVKYAPIVSFEECERKFKATEKE-LKDQLSEQTQKYSVSEEEVKKNKQENDKL 1033
Query: 480 QQKYTNIVKEMKAKDLEI-------RIHKKKKCEIYRRLREFAKLYDTIRNERNKFV--- 529
+++ + K+++ K + I R +K E+ ++L++ ++ Y ++N + K V
Sbjct: 1034 KKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEEN 1093
Query: 530 -----------NLLHKAHQKVNEIKERHKMSLNELEILRNSAVSQER------------- 565
NLL K H + +++ K +E L+ S +R
Sbjct: 1094 AKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLH 1153
Query: 566 ----KLQNSMLKHANNVTIRESMQNDVRKIVSKLQEMKEKKEAQLNNIDRLANTITMIEE 621
+NS + A ++ I+E+ + +V I + L+E +E+ + ++ + +L + + ++
Sbjct: 1154 QLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQ 1213
Query: 622 EMVQLRKR--------------YEKAVQHRNESGVQLIEREEEICIFYEKINIQEKMKLN 667
+ +L R E + NE L + EE+C E++ +K +++
Sbjct: 1214 ALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVC---EEVLHAKKKEIS 1270
Query: 668 GEIEIHLLEEKI-QFLKMKIAEKQRQICVTQKLLPAKRSLDADLAVLQIQFSQCTDRIKD 726
+ E LL I Q +K +K+R + +R + ++ + ++ T+ + D
Sbjct: 1271 AKDEKELLHFSIEQEIK---DQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLND 1327
Query: 727 LEKQFVKPDGENRARFLPGKDLTEKEMIQKLDKLELQLAKKEEKLLEKDFIYEQVSRL-T 785
+E+ +G ++ + G K Q +D L+ Q+ E++L + D +++V +
Sbjct: 1328 VERLKQALNGLSQLTYTSGN--PTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYR 1385
Query: 786 DRLCSKTQG 794
L S QG
Sbjct: 1386 THLLSAAQG 1394
Score = 88.2 bits (217), Expect = 3e-17
Identities = 185/877 (21%), Positives = 377/877 (42%), Gaps = 118/877 (13%)
Query: 80 STQESEV--QLLQNAKRFTEQIQQQQFHLQQ--ADNFPE--AFSTEVSKMRE----QLLK 129
S E+E+ + L+ + F E +Q + LQ A E A + E +++E Q+ +
Sbjct: 435 SYSENEILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQ 494
Query: 130 YQNEYNAVKEREFHNQYRLNSLKEEKIIIVKEFEKITKPGEMEKKMKILRESTEELRKEI 189
++ V++R + ++ ++ ++ + + + G TEEL+ ++
Sbjct: 495 LEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGN--------HRLTEELKDQL 546
Query: 190 MQKKLEIKNLREDLASKQKQLLKEQKELEELLGHQVVLKDEVAHHQTIPVQIGKEIEKIT 249
K++ + ++ + Q+ + + +EE + L +E Q E EK
Sbjct: 547 KDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKG 606
Query: 250 RKKVEMEKKKIVLEQEVKTLNDSLKKVENKVSAIVDE-----KENVIKEVEGKRALLEIK 304
RK EME + L ++ L+ +K EN S++ +E K+ V E E +++L EI+
Sbjct: 607 RKVTEMEGQAKELSAKL-ALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIR 665
Query: 305 ERE---HNQLVKLLELARENEATSLTER----------GILDLNLRNSLIDKQNYHDELS 351
+ + N KL + + E + R I +L L+N + K+ L
Sbjct: 666 QLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLD 725
Query: 352 RK-QREKERDFR-NLRKMELLLKVSWDALRQTQALHQRLLLEMEAIPKDDSTLSERRREL 409
K +E+ + ++ + LKVS D + A+ L ++ + + +E++ E+
Sbjct: 726 NKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQ---KYTEKKLEM 782
Query: 410 HKEVEVAKRNLAQQKIISEMESKLVEQQLAEENKLLKEQENMKELVVNLLRMTQIKIDEK 469
K + N + K +S +E+ V + E +++ + N+ EL L + + K E
Sbjct: 783 EK---LLLENDSLSKDVSRLETVFVPPE-KHEKEIIALKSNIVELKKQLSELKK-KCGED 837
Query: 470 EQKSKDFLKAQQKYTNIVKEMKAKDLEIRIHKKKK-------CEIYRRLREFAKLYDTIR 522
++K + TN+ K M + + ++ H++ K + R L + K ++ I
Sbjct: 838 QEK---IHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDIN 894
Query: 523 NE----RNKFVNLLHKAHQKVNEIKERHKMSLNELEILRNSAVSQERKLQNSMLKHANNV 578
E ++K L N+IK + +SL E E +S RK+Q+S N
Sbjct: 895 QEFVKIKDKNEILKRNLENTQNQIKAEY-ISLAEHEAKMSSLSQSMRKVQDS------NA 947
Query: 579 TIRESMQNDVRKIVSKLQEMKEKKEAQLNNIDRLANTITMIEEEMVQLRKRYEKAVQHRN 638
I + + +IV+ E+K AQ +D + I + +V + K
Sbjct: 948 EILANYRKGQEEIVTLHAEIK----AQKKELDTIQECIKVKYAPIVSFEECERKFKATEK 1003
Query: 639 ESGVQLIEREEEICIFYEKI--NIQEKMKLNGEIEIHLLEEKIQFLKMKIAEKQRQICVT 696
E QL E+ ++ + E++ N QE KL + EI L++ ++ K + EK ++
Sbjct: 1004 ELKDQLSEQTQKYSVSEEEVKKNKQENDKL--KKEIFTLQKDLRD-KTVLIEKSHEM--- 1057
Query: 697 QKLLPAKR-SLDADLAVLQIQFSQCTDRIKDLEKQFVKPDGENRARFLPGKDLTEK---- 751
++ L K L+ L L ++++ +K+++++ V+ + + + L ++L +K
Sbjct: 1058 ERALSRKTDELNKQLKDLSQKYTE----VKNVKEKLVEENAKQTSEILAVQNLLQKQHVP 1113
Query: 752 -EMIQKLDK-LELQLAKKEEKLLEKDFIYEQVSRLTDRLCSKTQGCKQDTLLLAKKMNGY 809
E ++ L K L + +E+L YE+ + +L + K ++ LA+ +
Sbjct: 1114 LEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHL--- 1170
Query: 810 QRRIKNATEKMMALVAELSMKQALTIELQKEVREKEDFIFTCNSRIEKGLPLNKEIE--K 867
+IK A EK + ++ + +REKE+ +++E+ L E++ K
Sbjct: 1171 --QIKEAFEKEVGII-------------KASLREKEE---ESQNKMEEVSKLQSEVQNTK 1212
Query: 868 EWLKVLRDEEMHALAIAEKSQEFLEAD----NRQLPN 900
+ LK L E+ L+ + ++ LE N +L N
Sbjct: 1213 QALKKLETREVVDLSKYKATKSDLETQISSLNEKLAN 1249
Score = 77.8 bits (190), Expect = 4e-14
Identities = 109/514 (21%), Positives = 223/514 (43%), Gaps = 76/514 (14%)
Query: 64 MAALKAKYTLLHDAVMSTQESEVQLLQNAKRFTEQIQQQQFHLQ----QADNFPEA---- 115
+A +AK + L ++ Q+S ++L N ++ E+I ++ + D E
Sbjct: 925 LAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVK 984
Query: 116 -------------FSTEVSKMREQLLKYQNEYNAVKEREFHNQYRLNSLKEEKIIIVKEF 162
F ++++QL + +Y+ +E N+ + LK+E + K+
Sbjct: 985 YAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDL 1044
Query: 163 EK----ITKPGEMEKKMKILRESTEELRKEIMQKKLEIKNLREDLASKQKQLLKEQKELE 218
I K EME+ + + + K++ QK E+KN++E L + K+
Sbjct: 1045 RDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVE------ENAKQTS 1098
Query: 219 ELLGHQVVLKDEVAHHQTIPVQIGKEIEKITRKKVEMEKKKIVLEQEVKTLNDSLKKVEN 278
E+L Q +L+ Q +P++ + ++K +E L++E+K++ +K
Sbjct: 1099 EILAVQNLLQ-----KQHVPLEQVEALKKSLNGTIEN------LKEELKSMQRCYEK--- 1144
Query: 279 KVSAIVDEKENVIKEVEGKRALLEIKEREHNQLVKLLELARENEATSLTERGILDLNLRN 338
E++ V K L ++ E + N V L E + EA E GI+ +LR
Sbjct: 1145 -------EQQTVTK-------LHQLLENQKNSSVPLAEHLQIKEAFE-KEVGIIKASLRE 1189
Query: 339 SLIDKQNYHDELSRKQREKERDFRNLRKMELLLKVSWDALRQTQALHQRLLLEMEAIPKD 398
+ QN +E+S+ Q E + + L+K+E V L + +A L ++ ++ +
Sbjct: 1190 KEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVD---LSKYKATKSDLETQISSLNEK 1246
Query: 399 DSTLSERRRELHKEVEVAKRNLAQQKIISEMESKLVEQQLAEENKLLKEQENMKELVVNL 458
+ L+ + E+ +EV AK+ ++I ++ E +L+ + +E K KE+ + K L
Sbjct: 1247 LANLNRKYEEVCEEVLHAKK----KEISAKDEKELLHFSIEQEIKDQKERCD-KSLTTIT 1301
Query: 459 LRMTQIKIDEKEQKSKDFLKAQQKYTNIVKEMKAKDLEIRIHKKKKCEIYRRLREFAKLY 518
+I+ K+ ++KD K T ++ +++ + + + ++L
Sbjct: 1302 ELQRRIQESAKQIEAKD-----NKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLI 1356
Query: 519 DTIRNERNKFVNLLHKA---HQKVNEIKERHKMS 549
DT++++ L A HQ+V I H +S
Sbjct: 1357 DTLQHQVKSLEQQLADADRQHQEVIAIYRTHLLS 1390
Score = 42.0 bits (97), Expect = 0.003
Identities = 72/402 (17%), Positives = 150/402 (37%), Gaps = 82/402 (20%)
Query: 530 NLLHKAHQKVNEIKERHKMSLNELEILRNSAVSQERKLQNS-----------MLKHANNV 578
NL H + + +R ++ +LEI + RK+Q L+ V
Sbjct: 276 NLTHMQDEVNVKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEV 335
Query: 579 TIRESMQNDVRKIVSKLQEMKEKKEAQLNNIDRLANTITMIEEEMVQLRKRYEKAVQHRN 638
+ + ++++ K+ S L +++ E L I+ L N E + +
Sbjct: 336 MVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHL-------------- 381
Query: 639 ESGVQLIEREEEICIFYEKINIQEKMKLNGEIEIHL------------LEEKIQFLKMKI 686
SG R+E++ + ++ + + + I H+ L + + + +I
Sbjct: 382 GSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEI 441
Query: 687 AEKQ----RQIC--VTQKLLPAKRSLDADLAVLQI--------------QFSQCTDRIKD 726
+K+ R C Q L + L +A + Q Q D +KD
Sbjct: 442 LKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKD 501
Query: 727 LEKQFVKPDG---ENRARFLPGKD------------LTE------KEMIQKLDKLELQLA 765
++K+ + +G + + FL K+ LTE K++ K + ++
Sbjct: 502 VQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVG 561
Query: 766 KKEEKLLEKDFIYEQVSRLTDRLCSKTQGCKQDTLLLAKKMNGYQRRIKNATEKMMALVA 825
K ++ + + I E+ R +L + + +++ + + R++ +M
Sbjct: 562 KLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKV----TEMEGQAK 617
Query: 826 ELSMKQALTIELQKEVREKEDFIFTCNSRIEKGLPLNKEIEK 867
ELS K AL+I +K K N + +K + + +E EK
Sbjct: 618 ELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEK 659
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 115 bits (287), Expect = 3e-25
Identities = 168/817 (20%), Positives = 346/817 (42%), Gaps = 74/817 (9%)
Query: 114 EAFSTEVSKMREQLLKYQNEYNAVKEREFHNQYRLNSLKEEKIIIVKEFEKITKPGEMEK 173
+A E+ K +E+ K +NE ++++ N L+E+ + E E + EM
Sbjct: 855 QAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ---LQAETELYAEAEEMRV 911
Query: 174 KMKILRESTEELRKEIMQKKLEIKNLREDLASKQKQLLKEQKELEELLGHQVVLKDEVAH 233
++ ++ EE+ E+ + E ++ + L +++K++ ++ +LEE L++E A
Sbjct: 912 RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE------QLEEEEAA 965
Query: 234 HQTIPVQIGKEIEKIT--RKKVEMEKKKIVLEQEVKTLNDSLKKVENKVSAIVDEKENVI 291
Q + ++EK+T K ++E + +V++ + L+ K +E ++S D N+
Sbjct: 966 RQKL------QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERIS---DLTTNLA 1016
Query: 292 KEVEGKRALLEIKEREHNQLVKLLELARENEATSLTERGILDLNLRNSLIDKQNYHDELS 351
+E E + L ++K + H ++ LE+ + E S E L L D ++H++++
Sbjct: 1017 EEEEKAKNLTKLKNK-HESMISELEVRLKKEEKSRQELEKLKRKLEG---DASDFHEQIA 1072
Query: 352 RKQREKERDFRNLRKMELLLKVSWDALRQTQALHQRLLLEMEAIPKDDSTLSE---RRRE 408
Q + L K E L+ + L A L ++ + S L E R
Sbjct: 1073 DLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERA 1132
Query: 409 LHKEVEVAKRNLAQ--QKIISEMESKLVEQQLAEENKLLKEQE--NMKELVVNLLRMTQI 464
+ E KR+L + + + +E+E L +E + +EQE +K+ + R +
Sbjct: 1133 ARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEA 1192
Query: 465 KIDEKEQKSKDFLKAQQKYTNIVKEMKAK-DLEIRIHKKKKCEIYRRLREFAKLYDTIRN 523
++ E QK ++ + K KA D + +K+ ++ LR + + +
Sbjct: 1193 QVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH 1252
Query: 524 ERNKFVNLLHKAHQKVNEIKERHKMSLNELEILRNSAVSQERKLQNSMLKHANNVTIRES 583
++ K + + K ++ ER + LN+ + + E + ML A I+
Sbjct: 1253 KKKKLEAQVQELQSKCSD-GERARAELND----KVHKLQNEVESVTGMLNEAEGKAIK-- 1305
Query: 584 MQNDVRKIVSKLQEMKEKKEAQLNNIDRLANTITMIEEEMVQLRKRYEKAVQ-------H 636
+ DV + S+LQ+ +E + + ++ + +EEE L+ + ++ ++ H
Sbjct: 1306 LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1365
Query: 637 RNESGVQLIEREEEICIFYEKINIQEKMKLNGEIEIHLLEEKIQFLKMKIAEKQRQICVT 696
+ +QL + ++++ F + E+ K + EI L + + + +
Sbjct: 1366 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ----------QYEEKAAAY 1415
Query: 697 QKLLPAKRSLDADLAVLQIQFSQCTDRIKDLEK------QFVKPDGENRARFLPGKDLTE 750
KL K L +L L + + +LEK Q + + +++ +D E
Sbjct: 1416 DKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAE 1475
Query: 751 KEMIQKLDKLELQLAKKEEKLLEKDFIYEQVSRLTDRLCSKTQGCKQDTLLLAKKMNGYQ 810
E +K K L LA+ E+ LE E+ +++ K D ++ +
Sbjct: 1476 AEAREKETK-ALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSK 1534
Query: 811 RRIKNATEKMMALVAELSMKQALT--IELQKEVRE---KEDFIFTCNSRIEKGLPLNKEI 865
R ++ E+M + EL + T +L+ EV K F +R E+ +++
Sbjct: 1535 RALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQL 1594
Query: 866 EK---EWLKVLRDE-EMHALAIAEKSQEFLEADNRQL 898
++ E+ L DE + ALA A K + LE D + L
Sbjct: 1595 QRQLHEYETELEDERKQRALAAAAKKK--LEGDLKDL 1629
Score = 90.5 bits (223), Expect = 7e-18
Identities = 186/894 (20%), Positives = 373/894 (41%), Gaps = 148/894 (16%)
Query: 75 HDAVMSTQESEVQLLQNAKRFTEQIQQQ------QFHLQQADNFPEAFSTEVSKMREQLL 128
H++++S E ++ + +++ E+++++ FH Q AD ++++++ QL
Sbjct: 1032 HESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD-----LQAQIAELKMQLA 1086
Query: 129 KYQNEYNAVKER-EFHNQYRLNSLKEEKIIIVKEFE------------KITKPGEMEKKM 175
K + E A R + + N+LK+ ++E E + + EK+
Sbjct: 1087 KKEEELQAALARLDDEIAQKNNALKK-----IRELEGHISDLQEDLDSERAARNKAEKQK 1141
Query: 176 KILRESTEELRKEIMQKKLEIKNLREDLASKQKQLLKEQKEL--EELLGHQVVLKDEVAH 233
+ L E E L+ E+ + L+ +++L +K++Q + K+ EE H+ +++
Sbjct: 1142 RDLGEELEALKTEL-EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQK 1200
Query: 234 HQTIPVQIGKEIEKITRKKV----------------------------EMEKKKIVLEQE 265
H ++ +++E+ R K E+E KK LE +
Sbjct: 1201 HAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQ 1260
Query: 266 VK--------------TLNDSLKKVENKVSAIVDEKENVIKEVEGKR-ALLEIKEREHNQ 310
V+ LND + K++N+V ++ ++ E EGK L + +Q
Sbjct: 1261 VQELQSKCSDGERARAELNDKVHKLQNEVESVT----GMLNEAEGKAIKLAKDVASLSSQ 1316
Query: 311 LVKLLELARENEATSLTERGILDLNLRNSLIDKQNYHDELSRKQREKERDFRNLRKMELL 370
L EL +E L + LR ++ + D+L + K+ R++ + +
Sbjct: 1317 LQDTQELLQEETRQKLN----VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1372
Query: 371 LKVSWDALRQTQALHQRLLLEMEAIPKDDSTLSERRRELHKEVEVAKRNLAQQKIISEME 430
L S L Q +EA L E ++ KE+E NL QQ E
Sbjct: 1373 LSDSKKKL-------QDFASTVEA-------LEEGKKRFQKEIE----NLTQQ-----YE 1409
Query: 431 SKLVEQQLAEENKLLKEQENMKELVVNLLRMTQIKID-EKEQKSKDFLKAQQK--YTNIV 487
K E+ K +QE + +LVV+L Q+ + EK+Q+ D L A++K +
Sbjct: 1410 EKAAAYDKLEKTKNRLQQE-LDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYA 1468
Query: 488 KEMKAKDLEIRIHKKKKCEIYRRL-------REFAKLYDTIRNERNKFVNLLHKAHQKVN 540
E + E R + K + R L E + ++ E V+ + V+
Sbjct: 1469 DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVH 1528
Query: 541 EIKERHKMSLNELEILRNSAVSQERKLQNSMLKHANNVTIRESMQNDVRKIVSKLQEMKE 600
E+++ + ++E ++ E +LQ + ++++ + + E E
Sbjct: 1529 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1588
Query: 601 KKEAQLNNIDRLANTITMIEEEMVQLRKRYEKAVQHRNESGVQLIEREEEICIFYEKINI 660
+K QL +L T +E+E Q + A + + E ++ +E + + I + I
Sbjct: 1589 EKRRQLQR--QLHEYETELEDERKQ--RALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1644
Query: 661 QEKMKLNGEIEIHLLEEKIQFLKMKIAEKQRQICVTQKLLPAKRSLDADLAVLQ--IQFS 718
++ KL +++ E L+ A + ++ +SL+ADL LQ + +
Sbjct: 1645 KQLRKLQAQMKDFQRE-----LEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAA 1699
Query: 719 QCTDRIKDLEKQFVKPDGENRARFLPGKDLTEKEMIQKLDKLELQLAKKEEKLLEKDFIY 778
+ + DLEK+ + E A L G++ + E +LE ++A+ EE+L E+
Sbjct: 1700 ERARKQADLEKEEL---AEELASSLSGRNALQDEK----RRLEARIAQLEEELEEEQGNM 1752
Query: 779 EQVSRLTDRLCSKTQGCKQDTLLLAKKMNGYQRRIKNATEKMMALVAELSMKQALTIELQ 838
E +S DR+ TQ +Q + LA + + Q+ ++A +++ EL K E++
Sbjct: 1753 EAMS---DRVRKATQQAEQLSNELATERSTAQKN-ESARQQLERQNKELRSK---LHEME 1805
Query: 839 KEVREKEDFIFTCNSRIEKGLPLNKEIEKEWLKVLRDEEMHALAIAEKSQEFLE 892
V+ K F T + K L +++E+E R+++ ++ +K ++ E
Sbjct: 1806 GAVKSK--FKSTIAALEAKIAQLEEQVEQE----AREKQAATKSLKQKDKKLKE 1853
Score = 83.6 bits (205), Expect = 8e-16
Identities = 125/671 (18%), Positives = 272/671 (40%), Gaps = 60/671 (8%)
Query: 4 SSTDTEKEEEEEKDEKDQEPIYAIVPTINIQDERFVDLSETPAFI---------FLHELH 54
S + + E +K K Q + ++ +N + + + L++ A + L E
Sbjct: 1269 SDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEET 1328
Query: 55 AMGKLPGTRMAALKAKYTLLHDAVMSTQESEVQLLQNAKRFTEQIQQQQFHLQQADNFPE 114
T++ L+ + L D + E++ L ++ Q+ + LQ + E
Sbjct: 1329 RQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVE 1388
Query: 115 A-------FSTEVSKMREQLLKYQNEYNAVKEREFHNQYRLNSLK---EEKIIIVKEFEK 164
A F E+ + +Q + Y+ +++ + Q L+ L + + +V EK
Sbjct: 1389 ALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEK 1448
Query: 165 ITKPGEM---EKKMKILRESTEELRKEIMQKKLEIKNLREDLASKQKQLLKEQKELEELL 221
+ + E+K + + E R E ++ E K L LA ++ L+ ++ELE
Sbjct: 1449 KQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL--SLARALEEALEAKEELERT- 1505
Query: 222 GHQVVLKDEVAHHQTIPVQIGKEIEKITRKKVEMEKKKIVLEQEVKTLNDSLKKVENKVS 281
+LK E+ + +GK + E+EK K LE +++ + L+++E+++
Sbjct: 1506 --NKMLKAEMEDLVSSKDDVGKNVH-------ELEKSKRALETQMEEMKTQLEELEDELQ 1556
Query: 282 AIVDEK---ENVIKEVEGK-----RALLEIKEREHNQLVKLL---ELARENEATSLTERG 330
A D K E ++ ++G+ +A E E + QL + L E E+E
Sbjct: 1557 ATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAA 1616
Query: 331 ILDLNLRNSLIDKQNYHDELSRKQREKERDFRNLRKMELLLKVSWDALRQTQALHQRLLL 390
L L D + D + + E + LRK++ +K L +A +
Sbjct: 1617 AAKKKLEGDLKDLELQADSAIKGREEA---IKQLRKLQAQMKDFQRELEDARASRDEIFA 1673
Query: 391 EMEAIPKDDSTLSERRRELHKEVEVAKRNLAQQKIISEMESKLVEQQLAEENKLLKEQEN 450
+ K +L +L +++ A+R Q + E ++ + L+ N L E+
Sbjct: 1674 TAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRR 1733
Query: 451 MKELVVNLLRMTQIKIDEKEQKSKDFLKAQQKYTNIVKEMKAKDLEIRIHKKKKCEIYRR 510
++ + L + + E S KA Q+ + E+ + + ++ + ++ R+
Sbjct: 1734 LEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQ 1793
Query: 511 LREF-AKLYDTIRNERNKFVNLLHKAHQKVNEIKERHKMSLNELEILRNSAVSQERKLQN 569
+E +KL++ ++KF + + K+ +++E+ + E + S +++KL+
Sbjct: 1794 NKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKE 1853
Query: 570 SMLKHANNVTIRESMQNDVRKIVSKLQEMKEKKEAQLNNIDRLANTITMIEEEMVQLRKR 629
+L+ D RK+ + +E EK A++ + R + + R++
Sbjct: 1854 ILLQ-----------VEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRK 1902
Query: 630 YEKAVQHRNES 640
++ + ES
Sbjct: 1903 LQRELDEATES 1913
Score = 80.9 bits (198), Expect = 5e-15
Identities = 119/597 (19%), Positives = 261/597 (43%), Gaps = 99/597 (16%)
Query: 263 EQEVKTLNDSLKKVENKVSAIVDEKENVIKEVEGKRA-LLEIKEREHNQLVKLLELAREN 321
E+E++ D L+K + + + EN +KE+E K + L E K QL EL E
Sbjct: 851 EEEMQAKEDELQKTKERQQ----KAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 906
Query: 322 EATSLTERGILDLNLRNSLIDKQNYHDELSRKQREKERDFRNLRKMELLLKVSWDALRQT 381
E ++ +R L+ K++E E L +ME L+ D +Q
Sbjct: 907 E----------EMRVR------------LAAKKQELEEI---LHEMEARLEEEEDRGQQL 941
Query: 382 QALHQRLLLEMEAIPKDDSTLSERRRELHKEVEVAKRNLAQQKIISEMESKLVEQQLA-- 439
QA +++ +M + E +E E A++ L +K+ +E + K +E ++
Sbjct: 942 QAERKKMAQQMLDL-----------EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVM 990
Query: 440 --EENKLLKEQENMKELVVNLLRMTQIKIDEKEQKSKDFLKAQQKYTNIVKEMKAKDLEI 497
+ NKL KE++ ++E + +L + E+E+K+K+ K + K+ +++ E LE+
Sbjct: 991 DDQNNKLSKERKLLEERISDLTT----NLAEEEEKAKNLTKLKNKHESMISE-----LEV 1041
Query: 498 RIHKKKKCEIYRRLREFAKLYDTIRNERNKFVNLLHKAHQKVNEIKERHKMSLNELEILR 557
R+ K++K +E KL + + + F H+++ +++ ++ L+
Sbjct: 1042 RLKKEEKSR-----QELEKLKRKLEGDASDF-------HEQIADLQA-------QIAELK 1082
Query: 558 NSAVSQERKLQNSMLKHANNVTIRESMQNDVRKI---VSKLQEMKEKKEAQLNNIDRLAN 614
+E +LQ ++ + + + + + +R++ +S LQE + + A N ++
Sbjct: 1083 MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1142
Query: 615 TITMIEEEMVQLRKRYEKAVQHRNESGVQLIEREEEICIFYEKINIQEKMKLNGEIEIHL 674
+ EE+ L+ E + +RE+E+ + K L+ E H
Sbjct: 1143 D---LGEELEALKTELEDTLDSTATQQELRAKREQEVTVL--------KKALDEETRSH- 1190
Query: 675 LEEKIQFLKMKIAEKQRQIC-VTQKLLPAKRSLDADLAVLQIQFSQCTDRIKDLEKQFVK 733
E ++Q ++ K A+ ++ ++ AK +LD + L+ + + ++ L + K
Sbjct: 1191 -EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ--AK 1247
Query: 734 PDGENRARFLPGKDLTEKEMIQKLDKLELQLAKKEEKLLEKDFIYEQVSRLTDRLCSKTQ 793
+ E++ + L + +E+ K E A+ +K+ + E V+ + + K
Sbjct: 1248 QEVEHKKKKL---EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAI 1304
Query: 794 GCKQDTLLLAKKMNGYQRRIKNATEKMMALVAELSM----KQALTIELQKEVREKED 846
+D L+ ++ Q ++ T + + + +L + +L +L +E+ K++
Sbjct: 1305 KLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQN 1361
Score = 63.9 bits (154), Expect = 7e-10
Identities = 93/502 (18%), Positives = 207/502 (41%), Gaps = 67/502 (13%)
Query: 105 HLQQADNFPEAFSTEVSKMREQLLKYQNEYNAVKEREFHNQYRLNSLKEEKIIIVKEFEK 164
++ + + A T++ +M+ QL + ++E A ++ + + + +LK
Sbjct: 1526 NVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALK------------ 1573
Query: 165 ITKPGEMEKKMKILRESTEELRKEIMQKKLEIKNLREDLASKQKQLLKEQKELEELLGHQ 224
G+ E+ ++ E EE R+++ ++ E + ED ++ +K+LE
Sbjct: 1574 ----GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEG----- 1624
Query: 225 VVLKDEVAHHQTIPVQIGKEIEKITRKKVEMEKKKIVLEQEVKTLNDSLKKVENKVSAIV 284
LKD + +Q I+ ++ K + ++ + L D+ + +++ A
Sbjct: 1625 -DLKD-------LELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDA-RASRDEIFATA 1675
Query: 285 DEKENVIKEVEGKRALLEIKEREHNQLVKLLELARENEATSLTERGILDLNLRNSLID-K 343
E E K +E L+ + K +L +E A L L+ RN+L D K
Sbjct: 1676 KENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELAS----SLSGRNALQDEK 1731
Query: 344 QNYHDELSRKQREKERDFRNLRKMELLLKVSWDALRQTQALHQRLLLEMEAIPKDDSTLS 403
+ +++ + E E + N+ M ++ A +Q + L L E K++S
Sbjct: 1732 RRLEARIAQLEEELEEEQGNMEAMSDRVR---KATQQAEQLSNELATERSTAQKNES--- 1785
Query: 404 ERRRELHKEVEVAKRNLAQQKIISEMESKLVEQQLAEENKLLKEQENMKELVVNLLRMTQ 463
A++ L +Q E+ SKL E + A ++K K + L +
Sbjct: 1786 ------------ARQQLERQN--KELRSKLHEMEGAVKSK-------FKSTIAAL----E 1820
Query: 464 IKIDEKEQKSKDFLKAQQKYTNIVKEMKAKDLEIRIHKKKKCEIYRRLREFAKLYDTIRN 523
KI + E++ + + +Q T +K+ K EI + + + ++ + +E A+ +
Sbjct: 1821 AKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVK 1880
Query: 524 ERNKFVNLLHKAHQKVNEIKERHKMSLNELEILRNSAVSQERKLQNSMLKHANNVTIRES 583
+ + + + Q++N + + + L+E N A+ +E S L+ N + S
Sbjct: 1881 QLKRQLEEAEEESQRINANRRKLQRELDE-ATESNEAMGREVNALKSKLRRGNETSFVPS 1939
Query: 584 MQNDVRKIVSKLQEMKEKKEAQ 605
++ R+++ +E+ + +
Sbjct: 1940 RRSGGRRVIENADGSEEETDTR 1961
Score = 59.7 bits (143), Expect = 1e-08
Identities = 88/431 (20%), Positives = 181/431 (41%), Gaps = 81/431 (18%)
Query: 477 LKAQQKYTNIVKEMKAKDLEIRIHKKKKCEIYRRLREFAKLYDTIRNERNKFVNLLHKAH 536
+K + T +EM+AK+ E++ K+++ KA
Sbjct: 841 VKPLLQVTRQEEEMQAKEDELQKTKERQ----------------------------QKAE 872
Query: 537 QKVNEIKERHKMSLNELEILRNSAVSQERKLQNSMLKHANNVTIRESMQNDVRKIVSKLQ 596
++ E++++H E +L + +LQ +A +R + +++ L
Sbjct: 873 NELKELEQKHSQLTEEKNLL-------QEQLQAETELYAEAEEMRVRLAAKKQELEEILH 925
Query: 597 EMKEKKEAQLNNIDRLANTITMIEEEMVQLRKRYEKAVQHRNESGVQLIEREEEICIFYE 656
EM+ + E + + +L + ++M+ L ++ E+ R + ++ + E +I +
Sbjct: 926 EMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLED 985
Query: 657 KINIQEKMKLNGEIEIHLLEEKIQFLKMKIAEKQRQICVTQKLLPAKRSLDADLAVLQIQ 716
+I + + E LLEE+I L +AE++ + + L K ++ ++ L+++
Sbjct: 986 EILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK---AKNLTKLKNKHESMISELEVR 1042
Query: 717 FSQCTDRIKDLEKQFVKPDGENRARFLPGKDLTEK--EMIQKLDKLELQLAKKEEKLLEK 774
+ ++LEK K +G+ D E+ ++ ++ +L++QLAKKEE+L
Sbjct: 1043 LKKEEKSRQELEKLKRKLEGD-------ASDFHEQIADLQAQIAELKMQLAKKEEEL--- 1092
Query: 775 DFIYEQVSRLTDRLCSKTQGCKQDTLLLAKKMNGY----------QRRIKNATEKMMALV 824
++RL D + K K+ +++ G+ +R +N EK
Sbjct: 1093 ---QAALARLDDEIAQKNNALKK-----IRELEGHISDLQEDLDSERAARNKAEK----- 1139
Query: 825 AELSMKQALTIELQKEVREKEDFIFTCNSRIEKGLPLNKEIEKEWLKVLRDEE--MHALA 882
K+ L EL+ E ED + + ++ E L +E E LK DEE H
Sbjct: 1140 ----QKRDLGEELEALKTELEDTLDSTATQQE--LRAKREQEVTVLKKALDEETRSHEAQ 1193
Query: 883 IAEKSQEFLEA 893
+ E Q+ +A
Sbjct: 1194 VQEMRQKHAQA 1204
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 115 bits (287), Expect = 3e-25
Identities = 168/817 (20%), Positives = 346/817 (42%), Gaps = 74/817 (9%)
Query: 114 EAFSTEVSKMREQLLKYQNEYNAVKEREFHNQYRLNSLKEEKIIIVKEFEKITKPGEMEK 173
+A E+ K +E+ K +NE ++++ N L+E+ + E E + EM
Sbjct: 862 QAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ---LQAETELYAEAEEMRV 918
Query: 174 KMKILRESTEELRKEIMQKKLEIKNLREDLASKQKQLLKEQKELEELLGHQVVLKDEVAH 233
++ ++ EE+ E+ + E ++ + L +++K++ ++ +LEE L++E A
Sbjct: 919 RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE------QLEEEEAA 972
Query: 234 HQTIPVQIGKEIEKIT--RKKVEMEKKKIVLEQEVKTLNDSLKKVENKVSAIVDEKENVI 291
Q + ++EK+T K ++E + +V++ + L+ K +E ++S D N+
Sbjct: 973 RQKL------QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERIS---DLTTNLA 1023
Query: 292 KEVEGKRALLEIKEREHNQLVKLLELARENEATSLTERGILDLNLRNSLIDKQNYHDELS 351
+E E + L ++K + H ++ LE+ + E S E L L D ++H++++
Sbjct: 1024 EEEEKAKNLTKLKNK-HESMISELEVRLKKEEKSRQELEKLKRKLEG---DASDFHEQIA 1079
Query: 352 RKQREKERDFRNLRKMELLLKVSWDALRQTQALHQRLLLEMEAIPKDDSTLSE---RRRE 408
Q + L K E L+ + L A L ++ + S L E R
Sbjct: 1080 DLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERA 1139
Query: 409 LHKEVEVAKRNLAQ--QKIISEMESKLVEQQLAEENKLLKEQE--NMKELVVNLLRMTQI 464
+ E KR+L + + + +E+E L +E + +EQE +K+ + R +
Sbjct: 1140 ARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEA 1199
Query: 465 KIDEKEQKSKDFLKAQQKYTNIVKEMKAK-DLEIRIHKKKKCEIYRRLREFAKLYDTIRN 523
++ E QK ++ + K KA D + +K+ ++ LR + + +
Sbjct: 1200 QVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH 1259
Query: 524 ERNKFVNLLHKAHQKVNEIKERHKMSLNELEILRNSAVSQERKLQNSMLKHANNVTIRES 583
++ K + + K ++ ER + LN+ + + E + ML A I+
Sbjct: 1260 KKKKLEAQVQELQSKCSD-GERARAELND----KVHKLQNEVESVTGMLNEAEGKAIK-- 1312
Query: 584 MQNDVRKIVSKLQEMKEKKEAQLNNIDRLANTITMIEEEMVQLRKRYEKAVQ-------H 636
+ DV + S+LQ+ +E + + ++ + +EEE L+ + ++ ++ H
Sbjct: 1313 LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1372
Query: 637 RNESGVQLIEREEEICIFYEKINIQEKMKLNGEIEIHLLEEKIQFLKMKIAEKQRQICVT 696
+ +QL + ++++ F + E+ K + EI L + + + +
Sbjct: 1373 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ----------QYEEKAAAY 1422
Query: 697 QKLLPAKRSLDADLAVLQIQFSQCTDRIKDLEK------QFVKPDGENRARFLPGKDLTE 750
KL K L +L L + + +LEK Q + + +++ +D E
Sbjct: 1423 DKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAE 1482
Query: 751 KEMIQKLDKLELQLAKKEEKLLEKDFIYEQVSRLTDRLCSKTQGCKQDTLLLAKKMNGYQ 810
E +K K L LA+ E+ LE E+ +++ K D ++ +
Sbjct: 1483 AEAREKETK-ALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSK 1541
Query: 811 RRIKNATEKMMALVAELSMKQALT--IELQKEVRE---KEDFIFTCNSRIEKGLPLNKEI 865
R ++ E+M + EL + T +L+ EV K F +R E+ +++
Sbjct: 1542 RALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQL 1601
Query: 866 EK---EWLKVLRDE-EMHALAIAEKSQEFLEADNRQL 898
++ E+ L DE + ALA A K + LE D + L
Sbjct: 1602 QRQLHEYETELEDERKQRALAAAAKKK--LEGDLKDL 1636
Score = 90.5 bits (223), Expect = 7e-18
Identities = 186/894 (20%), Positives = 373/894 (41%), Gaps = 148/894 (16%)
Query: 75 HDAVMSTQESEVQLLQNAKRFTEQIQQQ------QFHLQQADNFPEAFSTEVSKMREQLL 128
H++++S E ++ + +++ E+++++ FH Q AD ++++++ QL
Sbjct: 1039 HESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD-----LQAQIAELKMQLA 1093
Query: 129 KYQNEYNAVKER-EFHNQYRLNSLKEEKIIIVKEFE------------KITKPGEMEKKM 175
K + E A R + + N+LK+ ++E E + + EK+
Sbjct: 1094 KKEEELQAALARLDDEIAQKNNALKK-----IRELEGHISDLQEDLDSERAARNKAEKQK 1148
Query: 176 KILRESTEELRKEIMQKKLEIKNLREDLASKQKQLLKEQKEL--EELLGHQVVLKDEVAH 233
+ L E E L+ E+ + L+ +++L +K++Q + K+ EE H+ +++
Sbjct: 1149 RDLGEELEALKTEL-EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQK 1207
Query: 234 HQTIPVQIGKEIEKITRKKV----------------------------EMEKKKIVLEQE 265
H ++ +++E+ R K E+E KK LE +
Sbjct: 1208 HAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQ 1267
Query: 266 VK--------------TLNDSLKKVENKVSAIVDEKENVIKEVEGKR-ALLEIKEREHNQ 310
V+ LND + K++N+V ++ ++ E EGK L + +Q
Sbjct: 1268 VQELQSKCSDGERARAELNDKVHKLQNEVESVT----GMLNEAEGKAIKLAKDVASLSSQ 1323
Query: 311 LVKLLELARENEATSLTERGILDLNLRNSLIDKQNYHDELSRKQREKERDFRNLRKMELL 370
L EL +E L + LR ++ + D+L + K+ R++ + +
Sbjct: 1324 LQDTQELLQEETRQKLN----VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1379
Query: 371 LKVSWDALRQTQALHQRLLLEMEAIPKDDSTLSERRRELHKEVEVAKRNLAQQKIISEME 430
L S L Q +EA L E ++ KE+E NL QQ E
Sbjct: 1380 LSDSKKKL-------QDFASTVEA-------LEEGKKRFQKEIE----NLTQQ-----YE 1416
Query: 431 SKLVEQQLAEENKLLKEQENMKELVVNLLRMTQIKID-EKEQKSKDFLKAQQK--YTNIV 487
K E+ K +QE + +LVV+L Q+ + EK+Q+ D L A++K +
Sbjct: 1417 EKAAAYDKLEKTKNRLQQE-LDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYA 1475
Query: 488 KEMKAKDLEIRIHKKKKCEIYRRL-------REFAKLYDTIRNERNKFVNLLHKAHQKVN 540
E + E R + K + R L E + ++ E V+ + V+
Sbjct: 1476 DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVH 1535
Query: 541 EIKERHKMSLNELEILRNSAVSQERKLQNSMLKHANNVTIRESMQNDVRKIVSKLQEMKE 600
E+++ + ++E ++ E +LQ + ++++ + + E E
Sbjct: 1536 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1595
Query: 601 KKEAQLNNIDRLANTITMIEEEMVQLRKRYEKAVQHRNESGVQLIEREEEICIFYEKINI 660
+K QL +L T +E+E Q + A + + E ++ +E + + I + I
Sbjct: 1596 EKRRQLQR--QLHEYETELEDERKQ--RALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1651
Query: 661 QEKMKLNGEIEIHLLEEKIQFLKMKIAEKQRQICVTQKLLPAKRSLDADLAVLQ--IQFS 718
++ KL +++ E L+ A + ++ +SL+ADL LQ + +
Sbjct: 1652 KQLRKLQAQMKDFQRE-----LEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAA 1706
Query: 719 QCTDRIKDLEKQFVKPDGENRARFLPGKDLTEKEMIQKLDKLELQLAKKEEKLLEKDFIY 778
+ + DLEK+ + E A L G++ + E +LE ++A+ EE+L E+
Sbjct: 1707 ERARKQADLEKEEL---AEELASSLSGRNALQDEK----RRLEARIAQLEEELEEEQGNM 1759
Query: 779 EQVSRLTDRLCSKTQGCKQDTLLLAKKMNGYQRRIKNATEKMMALVAELSMKQALTIELQ 838
E +S DR+ TQ +Q + LA + + Q+ ++A +++ EL K E++
Sbjct: 1760 EAMS---DRVRKATQQAEQLSNELATERSTAQKN-ESARQQLERQNKELRSK---LHEME 1812
Query: 839 KEVREKEDFIFTCNSRIEKGLPLNKEIEKEWLKVLRDEEMHALAIAEKSQEFLE 892
V+ K F T + K L +++E+E R+++ ++ +K ++ E
Sbjct: 1813 GAVKSK--FKSTIAALEAKIAQLEEQVEQE----AREKQAATKSLKQKDKKLKE 1860
Score = 83.6 bits (205), Expect = 8e-16
Identities = 125/671 (18%), Positives = 272/671 (40%), Gaps = 60/671 (8%)
Query: 4 SSTDTEKEEEEEKDEKDQEPIYAIVPTINIQDERFVDLSETPAFI---------FLHELH 54
S + + E +K K Q + ++ +N + + + L++ A + L E
Sbjct: 1276 SDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEET 1335
Query: 55 AMGKLPGTRMAALKAKYTLLHDAVMSTQESEVQLLQNAKRFTEQIQQQQFHLQQADNFPE 114
T++ L+ + L D + E++ L ++ Q+ + LQ + E
Sbjct: 1336 RQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVE 1395
Query: 115 A-------FSTEVSKMREQLLKYQNEYNAVKEREFHNQYRLNSLK---EEKIIIVKEFEK 164
A F E+ + +Q + Y+ +++ + Q L+ L + + +V EK
Sbjct: 1396 ALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEK 1455
Query: 165 ITKPGEM---EKKMKILRESTEELRKEIMQKKLEIKNLREDLASKQKQLLKEQKELEELL 221
+ + E+K + + E R E ++ E K L LA ++ L+ ++ELE
Sbjct: 1456 KQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL--SLARALEEALEAKEELERT- 1512
Query: 222 GHQVVLKDEVAHHQTIPVQIGKEIEKITRKKVEMEKKKIVLEQEVKTLNDSLKKVENKVS 281
+LK E+ + +GK + E+EK K LE +++ + L+++E+++
Sbjct: 1513 --NKMLKAEMEDLVSSKDDVGKNVH-------ELEKSKRALETQMEEMKTQLEELEDELQ 1563
Query: 282 AIVDEK---ENVIKEVEGK-----RALLEIKEREHNQLVKLL---ELARENEATSLTERG 330
A D K E ++ ++G+ +A E E + QL + L E E+E
Sbjct: 1564 ATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAA 1623
Query: 331 ILDLNLRNSLIDKQNYHDELSRKQREKERDFRNLRKMELLLKVSWDALRQTQALHQRLLL 390
L L D + D + + E + LRK++ +K L +A +
Sbjct: 1624 AAKKKLEGDLKDLELQADSAIKGREEA---IKQLRKLQAQMKDFQRELEDARASRDEIFA 1680
Query: 391 EMEAIPKDDSTLSERRRELHKEVEVAKRNLAQQKIISEMESKLVEQQLAEENKLLKEQEN 450
+ K +L +L +++ A+R Q + E ++ + L+ N L E+
Sbjct: 1681 TAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRR 1740
Query: 451 MKELVVNLLRMTQIKIDEKEQKSKDFLKAQQKYTNIVKEMKAKDLEIRIHKKKKCEIYRR 510
++ + L + + E S KA Q+ + E+ + + ++ + ++ R+
Sbjct: 1741 LEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQ 1800
Query: 511 LREF-AKLYDTIRNERNKFVNLLHKAHQKVNEIKERHKMSLNELEILRNSAVSQERKLQN 569
+E +KL++ ++KF + + K+ +++E+ + E + S +++KL+
Sbjct: 1801 NKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKE 1860
Query: 570 SMLKHANNVTIRESMQNDVRKIVSKLQEMKEKKEAQLNNIDRLANTITMIEEEMVQLRKR 629
+L+ D RK+ + +E EK A++ + R + + R++
Sbjct: 1861 ILLQ-----------VEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRK 1909
Query: 630 YEKAVQHRNES 640
++ + ES
Sbjct: 1910 LQRELDEATES 1920
Score = 80.9 bits (198), Expect = 5e-15
Identities = 119/597 (19%), Positives = 261/597 (43%), Gaps = 99/597 (16%)
Query: 263 EQEVKTLNDSLKKVENKVSAIVDEKENVIKEVEGKRA-LLEIKEREHNQLVKLLELAREN 321
E+E++ D L+K + + + EN +KE+E K + L E K QL EL E
Sbjct: 858 EEEMQAKEDELQKTKERQQ----KAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 913
Query: 322 EATSLTERGILDLNLRNSLIDKQNYHDELSRKQREKERDFRNLRKMELLLKVSWDALRQT 381
E ++ +R L+ K++E E L +ME L+ D +Q
Sbjct: 914 E----------EMRVR------------LAAKKQELEEI---LHEMEARLEEEEDRGQQL 948
Query: 382 QALHQRLLLEMEAIPKDDSTLSERRRELHKEVEVAKRNLAQQKIISEMESKLVEQQLA-- 439
QA +++ +M + E +E E A++ L +K+ +E + K +E ++
Sbjct: 949 QAERKKMAQQMLDL-----------EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVM 997
Query: 440 --EENKLLKEQENMKELVVNLLRMTQIKIDEKEQKSKDFLKAQQKYTNIVKEMKAKDLEI 497
+ NKL KE++ ++E + +L + E+E+K+K+ K + K+ +++ E LE+
Sbjct: 998 DDQNNKLSKERKLLEERISDLTT----NLAEEEEKAKNLTKLKNKHESMISE-----LEV 1048
Query: 498 RIHKKKKCEIYRRLREFAKLYDTIRNERNKFVNLLHKAHQKVNEIKERHKMSLNELEILR 557
R+ K++K +E KL + + + F H+++ +++ ++ L+
Sbjct: 1049 RLKKEEKSR-----QELEKLKRKLEGDASDF-------HEQIADLQA-------QIAELK 1089
Query: 558 NSAVSQERKLQNSMLKHANNVTIRESMQNDVRKI---VSKLQEMKEKKEAQLNNIDRLAN 614
+E +LQ ++ + + + + + +R++ +S LQE + + A N ++
Sbjct: 1090 MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1149
Query: 615 TITMIEEEMVQLRKRYEKAVQHRNESGVQLIEREEEICIFYEKINIQEKMKLNGEIEIHL 674
+ EE+ L+ E + +RE+E+ + K L+ E H
Sbjct: 1150 D---LGEELEALKTELEDTLDSTATQQELRAKREQEVTVL--------KKALDEETRSH- 1197
Query: 675 LEEKIQFLKMKIAEKQRQIC-VTQKLLPAKRSLDADLAVLQIQFSQCTDRIKDLEKQFVK 733
E ++Q ++ K A+ ++ ++ AK +LD + L+ + + ++ L + K
Sbjct: 1198 -EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ--AK 1254
Query: 734 PDGENRARFLPGKDLTEKEMIQKLDKLELQLAKKEEKLLEKDFIYEQVSRLTDRLCSKTQ 793
+ E++ + L + +E+ K E A+ +K+ + E V+ + + K
Sbjct: 1255 QEVEHKKKKL---EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAI 1311
Query: 794 GCKQDTLLLAKKMNGYQRRIKNATEKMMALVAELSM----KQALTIELQKEVREKED 846
+D L+ ++ Q ++ T + + + +L + +L +L +E+ K++
Sbjct: 1312 KLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQN 1368
Score = 63.9 bits (154), Expect = 7e-10
Identities = 93/502 (18%), Positives = 207/502 (41%), Gaps = 67/502 (13%)
Query: 105 HLQQADNFPEAFSTEVSKMREQLLKYQNEYNAVKEREFHNQYRLNSLKEEKIIIVKEFEK 164
++ + + A T++ +M+ QL + ++E A ++ + + + +LK
Sbjct: 1533 NVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALK------------ 1580
Query: 165 ITKPGEMEKKMKILRESTEELRKEIMQKKLEIKNLREDLASKQKQLLKEQKELEELLGHQ 224
G+ E+ ++ E EE R+++ ++ E + ED ++ +K+LE
Sbjct: 1581 ----GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEG----- 1631
Query: 225 VVLKDEVAHHQTIPVQIGKEIEKITRKKVEMEKKKIVLEQEVKTLNDSLKKVENKVSAIV 284
LKD + +Q I+ ++ K + ++ + L D+ + +++ A
Sbjct: 1632 -DLKD-------LELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDA-RASRDEIFATA 1682
Query: 285 DEKENVIKEVEGKRALLEIKEREHNQLVKLLELARENEATSLTERGILDLNLRNSLID-K 343
E E K +E L+ + K +L +E A L L+ RN+L D K
Sbjct: 1683 KENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELAS----SLSGRNALQDEK 1738
Query: 344 QNYHDELSRKQREKERDFRNLRKMELLLKVSWDALRQTQALHQRLLLEMEAIPKDDSTLS 403
+ +++ + E E + N+ M ++ A +Q + L L E K++S
Sbjct: 1739 RRLEARIAQLEEELEEEQGNMEAMSDRVR---KATQQAEQLSNELATERSTAQKNES--- 1792
Query: 404 ERRRELHKEVEVAKRNLAQQKIISEMESKLVEQQLAEENKLLKEQENMKELVVNLLRMTQ 463
A++ L +Q E+ SKL E + A ++K K + L +
Sbjct: 1793 ------------ARQQLERQN--KELRSKLHEMEGAVKSK-------FKSTIAAL----E 1827
Query: 464 IKIDEKEQKSKDFLKAQQKYTNIVKEMKAKDLEIRIHKKKKCEIYRRLREFAKLYDTIRN 523
KI + E++ + + +Q T +K+ K EI + + + ++ + +E A+ +
Sbjct: 1828 AKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVK 1887
Query: 524 ERNKFVNLLHKAHQKVNEIKERHKMSLNELEILRNSAVSQERKLQNSMLKHANNVTIRES 583
+ + + + Q++N + + + L+E N A+ +E S L+ N + S
Sbjct: 1888 QLKRQLEEAEEESQRINANRRKLQRELDE-ATESNEAMGREVNALKSKLRRGNETSFVPS 1946
Query: 584 MQNDVRKIVSKLQEMKEKKEAQ 605
++ R+++ +E+ + +
Sbjct: 1947 RRSGGRRVIENADGSEEETDTR 1968
Score = 59.7 bits (143), Expect = 1e-08
Identities = 88/431 (20%), Positives = 181/431 (41%), Gaps = 81/431 (18%)
Query: 477 LKAQQKYTNIVKEMKAKDLEIRIHKKKKCEIYRRLREFAKLYDTIRNERNKFVNLLHKAH 536
+K + T +EM+AK+ E++ K+++ KA
Sbjct: 848 VKPLLQVTRQEEEMQAKEDELQKTKERQ----------------------------QKAE 879
Query: 537 QKVNEIKERHKMSLNELEILRNSAVSQERKLQNSMLKHANNVTIRESMQNDVRKIVSKLQ 596
++ E++++H E +L + +LQ +A +R + +++ L
Sbjct: 880 NELKELEQKHSQLTEEKNLL-------QEQLQAETELYAEAEEMRVRLAAKKQELEEILH 932
Query: 597 EMKEKKEAQLNNIDRLANTITMIEEEMVQLRKRYEKAVQHRNESGVQLIEREEEICIFYE 656
EM+ + E + + +L + ++M+ L ++ E+ R + ++ + E +I +
Sbjct: 933 EMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLED 992
Query: 657 KINIQEKMKLNGEIEIHLLEEKIQFLKMKIAEKQRQICVTQKLLPAKRSLDADLAVLQIQ 716
+I + + E LLEE+I L +AE++ + + L K ++ ++ L+++
Sbjct: 993 EILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK---AKNLTKLKNKHESMISELEVR 1049
Query: 717 FSQCTDRIKDLEKQFVKPDGENRARFLPGKDLTEK--EMIQKLDKLELQLAKKEEKLLEK 774
+ ++LEK K +G+ D E+ ++ ++ +L++QLAKKEE+L
Sbjct: 1050 LKKEEKSRQELEKLKRKLEGD-------ASDFHEQIADLQAQIAELKMQLAKKEEEL--- 1099
Query: 775 DFIYEQVSRLTDRLCSKTQGCKQDTLLLAKKMNGY----------QRRIKNATEKMMALV 824
++RL D + K K+ +++ G+ +R +N EK
Sbjct: 1100 ---QAALARLDDEIAQKNNALKK-----IRELEGHISDLQEDLDSERAARNKAEK----- 1146
Query: 825 AELSMKQALTIELQKEVREKEDFIFTCNSRIEKGLPLNKEIEKEWLKVLRDEE--MHALA 882
K+ L EL+ E ED + + ++ E L +E E LK DEE H
Sbjct: 1147 ----QKRDLGEELEALKTELEDTLDSTATQQE--LRAKREQEVTVLKKALDEETRSHEAQ 1200
Query: 883 IAEKSQEFLEA 893
+ E Q+ +A
Sbjct: 1201 VQEMRQKHAQA 1211
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 115 bits (287), Expect = 3e-25
Identities = 168/817 (20%), Positives = 346/817 (42%), Gaps = 74/817 (9%)
Query: 114 EAFSTEVSKMREQLLKYQNEYNAVKEREFHNQYRLNSLKEEKIIIVKEFEKITKPGEMEK 173
+A E+ K +E+ K +NE ++++ N L+E+ + E E + EM
Sbjct: 862 QAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ---LQAETELYAEAEEMRV 918
Query: 174 KMKILRESTEELRKEIMQKKLEIKNLREDLASKQKQLLKEQKELEELLGHQVVLKDEVAH 233
++ ++ EE+ E+ + E ++ + L +++K++ ++ +LEE L++E A
Sbjct: 919 RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE------QLEEEEAA 972
Query: 234 HQTIPVQIGKEIEKIT--RKKVEMEKKKIVLEQEVKTLNDSLKKVENKVSAIVDEKENVI 291
Q + ++EK+T K ++E + +V++ + L+ K +E ++S D N+
Sbjct: 973 RQKL------QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERIS---DLTTNLA 1023
Query: 292 KEVEGKRALLEIKEREHNQLVKLLELARENEATSLTERGILDLNLRNSLIDKQNYHDELS 351
+E E + L ++K + H ++ LE+ + E S E L L D ++H++++
Sbjct: 1024 EEEEKAKNLTKLKNK-HESMISELEVRLKKEEKSRQELEKLKRKLEG---DASDFHEQIA 1079
Query: 352 RKQREKERDFRNLRKMELLLKVSWDALRQTQALHQRLLLEMEAIPKDDSTLSE---RRRE 408
Q + L K E L+ + L A L ++ + S L E R
Sbjct: 1080 DLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERA 1139
Query: 409 LHKEVEVAKRNLAQ--QKIISEMESKLVEQQLAEENKLLKEQE--NMKELVVNLLRMTQI 464
+ E KR+L + + + +E+E L +E + +EQE +K+ + R +
Sbjct: 1140 ARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEA 1199
Query: 465 KIDEKEQKSKDFLKAQQKYTNIVKEMKAK-DLEIRIHKKKKCEIYRRLREFAKLYDTIRN 523
++ E QK ++ + K KA D + +K+ ++ LR + + +
Sbjct: 1200 QVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH 1259
Query: 524 ERNKFVNLLHKAHQKVNEIKERHKMSLNELEILRNSAVSQERKLQNSMLKHANNVTIRES 583
++ K + + K ++ ER + LN+ + + E + ML A I+
Sbjct: 1260 KKKKLEAQVQELQSKCSD-GERARAELND----KVHKLQNEVESVTGMLNEAEGKAIK-- 1312
Query: 584 MQNDVRKIVSKLQEMKEKKEAQLNNIDRLANTITMIEEEMVQLRKRYEKAVQ-------H 636
+ DV + S+LQ+ +E + + ++ + +EEE L+ + ++ ++ H
Sbjct: 1313 LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1372
Query: 637 RNESGVQLIEREEEICIFYEKINIQEKMKLNGEIEIHLLEEKIQFLKMKIAEKQRQICVT 696
+ +QL + ++++ F + E+ K + EI L + + + +
Sbjct: 1373 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ----------QYEEKAAAY 1422
Query: 697 QKLLPAKRSLDADLAVLQIQFSQCTDRIKDLEK------QFVKPDGENRARFLPGKDLTE 750
KL K L +L L + + +LEK Q + + +++ +D E
Sbjct: 1423 DKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAE 1482
Query: 751 KEMIQKLDKLELQLAKKEEKLLEKDFIYEQVSRLTDRLCSKTQGCKQDTLLLAKKMNGYQ 810
E +K K L LA+ E+ LE E+ +++ K D ++ +
Sbjct: 1483 AEAREKETK-ALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSK 1541
Query: 811 RRIKNATEKMMALVAELSMKQALT--IELQKEVRE---KEDFIFTCNSRIEKGLPLNKEI 865
R ++ E+M + EL + T +L+ EV K F +R E+ +++
Sbjct: 1542 RALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQL 1601
Query: 866 EK---EWLKVLRDE-EMHALAIAEKSQEFLEADNRQL 898
++ E+ L DE + ALA A K + LE D + L
Sbjct: 1602 QRQLHEYETELEDERKQRALAAAAKKK--LEGDLKDL 1636
Score = 90.5 bits (223), Expect = 7e-18
Identities = 186/894 (20%), Positives = 373/894 (41%), Gaps = 148/894 (16%)
Query: 75 HDAVMSTQESEVQLLQNAKRFTEQIQQQ------QFHLQQADNFPEAFSTEVSKMREQLL 128
H++++S E ++ + +++ E+++++ FH Q AD ++++++ QL
Sbjct: 1039 HESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD-----LQAQIAELKMQLA 1093
Query: 129 KYQNEYNAVKER-EFHNQYRLNSLKEEKIIIVKEFE------------KITKPGEMEKKM 175
K + E A R + + N+LK+ ++E E + + EK+
Sbjct: 1094 KKEEELQAALARLDDEIAQKNNALKK-----IRELEGHISDLQEDLDSERAARNKAEKQK 1148
Query: 176 KILRESTEELRKEIMQKKLEIKNLREDLASKQKQLLKEQKEL--EELLGHQVVLKDEVAH 233
+ L E E L+ E+ + L+ +++L +K++Q + K+ EE H+ +++
Sbjct: 1149 RDLGEELEALKTEL-EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQK 1207
Query: 234 HQTIPVQIGKEIEKITRKKV----------------------------EMEKKKIVLEQE 265
H ++ +++E+ R K E+E KK LE +
Sbjct: 1208 HAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQ 1267
Query: 266 VK--------------TLNDSLKKVENKVSAIVDEKENVIKEVEGKR-ALLEIKEREHNQ 310
V+ LND + K++N+V ++ ++ E EGK L + +Q
Sbjct: 1268 VQELQSKCSDGERARAELNDKVHKLQNEVESVT----GMLNEAEGKAIKLAKDVASLSSQ 1323
Query: 311 LVKLLELARENEATSLTERGILDLNLRNSLIDKQNYHDELSRKQREKERDFRNLRKMELL 370
L EL +E L + LR ++ + D+L + K+ R++ + +
Sbjct: 1324 LQDTQELLQEETRQKLN----VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1379
Query: 371 LKVSWDALRQTQALHQRLLLEMEAIPKDDSTLSERRRELHKEVEVAKRNLAQQKIISEME 430
L S L Q +EA L E ++ KE+E NL QQ E
Sbjct: 1380 LSDSKKKL-------QDFASTVEA-------LEEGKKRFQKEIE----NLTQQ-----YE 1416
Query: 431 SKLVEQQLAEENKLLKEQENMKELVVNLLRMTQIKID-EKEQKSKDFLKAQQK--YTNIV 487
K E+ K +QE + +LVV+L Q+ + EK+Q+ D L A++K +
Sbjct: 1417 EKAAAYDKLEKTKNRLQQE-LDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYA 1475
Query: 488 KEMKAKDLEIRIHKKKKCEIYRRL-------REFAKLYDTIRNERNKFVNLLHKAHQKVN 540
E + E R + K + R L E + ++ E V+ + V+
Sbjct: 1476 DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVH 1535
Query: 541 EIKERHKMSLNELEILRNSAVSQERKLQNSMLKHANNVTIRESMQNDVRKIVSKLQEMKE 600
E+++ + ++E ++ E +LQ + ++++ + + E E
Sbjct: 1536 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1595
Query: 601 KKEAQLNNIDRLANTITMIEEEMVQLRKRYEKAVQHRNESGVQLIEREEEICIFYEKINI 660
+K QL +L T +E+E Q + A + + E ++ +E + + I + I
Sbjct: 1596 EKRRQLQR--QLHEYETELEDERKQ--RALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1651
Query: 661 QEKMKLNGEIEIHLLEEKIQFLKMKIAEKQRQICVTQKLLPAKRSLDADLAVLQ--IQFS 718
++ KL +++ E L+ A + ++ +SL+ADL LQ + +
Sbjct: 1652 KQLRKLQAQMKDFQRE-----LEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAA 1706
Query: 719 QCTDRIKDLEKQFVKPDGENRARFLPGKDLTEKEMIQKLDKLELQLAKKEEKLLEKDFIY 778
+ + DLEK+ + E A L G++ + E +LE ++A+ EE+L E+
Sbjct: 1707 ERARKQADLEKEEL---AEELASSLSGRNALQDEK----RRLEARIAQLEEELEEEQGNM 1759
Query: 779 EQVSRLTDRLCSKTQGCKQDTLLLAKKMNGYQRRIKNATEKMMALVAELSMKQALTIELQ 838
E +S DR+ TQ +Q + LA + + Q+ ++A +++ EL K E++
Sbjct: 1760 EAMS---DRVRKATQQAEQLSNELATERSTAQKN-ESARQQLERQNKELRSK---LHEME 1812
Query: 839 KEVREKEDFIFTCNSRIEKGLPLNKEIEKEWLKVLRDEEMHALAIAEKSQEFLE 892
V+ K F T + K L +++E+E R+++ ++ +K ++ E
Sbjct: 1813 GAVKSK--FKSTIAALEAKIAQLEEQVEQE----AREKQAATKSLKQKDKKLKE 1860
Score = 83.6 bits (205), Expect = 8e-16
Identities = 125/671 (18%), Positives = 272/671 (40%), Gaps = 60/671 (8%)
Query: 4 SSTDTEKEEEEEKDEKDQEPIYAIVPTINIQDERFVDLSETPAFI---------FLHELH 54
S + + E +K K Q + ++ +N + + + L++ A + L E
Sbjct: 1276 SDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEET 1335
Query: 55 AMGKLPGTRMAALKAKYTLLHDAVMSTQESEVQLLQNAKRFTEQIQQQQFHLQQADNFPE 114
T++ L+ + L D + E++ L ++ Q+ + LQ + E
Sbjct: 1336 RQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVE 1395
Query: 115 A-------FSTEVSKMREQLLKYQNEYNAVKEREFHNQYRLNSLK---EEKIIIVKEFEK 164
A F E+ + +Q + Y+ +++ + Q L+ L + + +V EK
Sbjct: 1396 ALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEK 1455
Query: 165 ITKPGEM---EKKMKILRESTEELRKEIMQKKLEIKNLREDLASKQKQLLKEQKELEELL 221
+ + E+K + + E R E ++ E K L LA ++ L+ ++ELE
Sbjct: 1456 KQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL--SLARALEEALEAKEELERT- 1512
Query: 222 GHQVVLKDEVAHHQTIPVQIGKEIEKITRKKVEMEKKKIVLEQEVKTLNDSLKKVENKVS 281
+LK E+ + +GK + E+EK K LE +++ + L+++E+++
Sbjct: 1513 --NKMLKAEMEDLVSSKDDVGKNVH-------ELEKSKRALETQMEEMKTQLEELEDELQ 1563
Query: 282 AIVDEK---ENVIKEVEGK-----RALLEIKEREHNQLVKLL---ELARENEATSLTERG 330
A D K E ++ ++G+ +A E E + QL + L E E+E
Sbjct: 1564 ATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAA 1623
Query: 331 ILDLNLRNSLIDKQNYHDELSRKQREKERDFRNLRKMELLLKVSWDALRQTQALHQRLLL 390
L L D + D + + E + LRK++ +K L +A +
Sbjct: 1624 AAKKKLEGDLKDLELQADSAIKGREEA---IKQLRKLQAQMKDFQRELEDARASRDEIFA 1680
Query: 391 EMEAIPKDDSTLSERRRELHKEVEVAKRNLAQQKIISEMESKLVEQQLAEENKLLKEQEN 450
+ K +L +L +++ A+R Q + E ++ + L+ N L E+
Sbjct: 1681 TAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRR 1740
Query: 451 MKELVVNLLRMTQIKIDEKEQKSKDFLKAQQKYTNIVKEMKAKDLEIRIHKKKKCEIYRR 510
++ + L + + E S KA Q+ + E+ + + ++ + ++ R+
Sbjct: 1741 LEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQ 1800
Query: 511 LREF-AKLYDTIRNERNKFVNLLHKAHQKVNEIKERHKMSLNELEILRNSAVSQERKLQN 569
+E +KL++ ++KF + + K+ +++E+ + E + S +++KL+
Sbjct: 1801 NKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKE 1860
Query: 570 SMLKHANNVTIRESMQNDVRKIVSKLQEMKEKKEAQLNNIDRLANTITMIEEEMVQLRKR 629
+L+ D RK+ + +E EK A++ + R + + R++
Sbjct: 1861 ILLQ-----------VEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRK 1909
Query: 630 YEKAVQHRNES 640
++ + ES
Sbjct: 1910 LQRELDEATES 1920
Score = 80.9 bits (198), Expect = 5e-15
Identities = 119/597 (19%), Positives = 261/597 (43%), Gaps = 99/597 (16%)
Query: 263 EQEVKTLNDSLKKVENKVSAIVDEKENVIKEVEGKRA-LLEIKEREHNQLVKLLELAREN 321
E+E++ D L+K + + + EN +KE+E K + L E K QL EL E
Sbjct: 858 EEEMQAKEDELQKTKERQQ----KAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 913
Query: 322 EATSLTERGILDLNLRNSLIDKQNYHDELSRKQREKERDFRNLRKMELLLKVSWDALRQT 381
E ++ +R L+ K++E E L +ME L+ D +Q
Sbjct: 914 E----------EMRVR------------LAAKKQELEEI---LHEMEARLEEEEDRGQQL 948
Query: 382 QALHQRLLLEMEAIPKDDSTLSERRRELHKEVEVAKRNLAQQKIISEMESKLVEQQLA-- 439
QA +++ +M + E +E E A++ L +K+ +E + K +E ++
Sbjct: 949 QAERKKMAQQMLDL-----------EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVM 997
Query: 440 --EENKLLKEQENMKELVVNLLRMTQIKIDEKEQKSKDFLKAQQKYTNIVKEMKAKDLEI 497
+ NKL KE++ ++E + +L + E+E+K+K+ K + K+ +++ E LE+
Sbjct: 998 DDQNNKLSKERKLLEERISDLTT----NLAEEEEKAKNLTKLKNKHESMISE-----LEV 1048
Query: 498 RIHKKKKCEIYRRLREFAKLYDTIRNERNKFVNLLHKAHQKVNEIKERHKMSLNELEILR 557
R+ K++K +E KL + + + F H+++ +++ ++ L+
Sbjct: 1049 RLKKEEKSR-----QELEKLKRKLEGDASDF-------HEQIADLQA-------QIAELK 1089
Query: 558 NSAVSQERKLQNSMLKHANNVTIRESMQNDVRKI---VSKLQEMKEKKEAQLNNIDRLAN 614
+E +LQ ++ + + + + + +R++ +S LQE + + A N ++
Sbjct: 1090 MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1149
Query: 615 TITMIEEEMVQLRKRYEKAVQHRNESGVQLIEREEEICIFYEKINIQEKMKLNGEIEIHL 674
+ EE+ L+ E + +RE+E+ + K L+ E H
Sbjct: 1150 D---LGEELEALKTELEDTLDSTATQQELRAKREQEVTVL--------KKALDEETRSH- 1197
Query: 675 LEEKIQFLKMKIAEKQRQIC-VTQKLLPAKRSLDADLAVLQIQFSQCTDRIKDLEKQFVK 733
E ++Q ++ K A+ ++ ++ AK +LD + L+ + + ++ L + K
Sbjct: 1198 -EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ--AK 1254
Query: 734 PDGENRARFLPGKDLTEKEMIQKLDKLELQLAKKEEKLLEKDFIYEQVSRLTDRLCSKTQ 793
+ E++ + L + +E+ K E A+ +K+ + E V+ + + K
Sbjct: 1255 QEVEHKKKKL---EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAI 1311
Query: 794 GCKQDTLLLAKKMNGYQRRIKNATEKMMALVAELSM----KQALTIELQKEVREKED 846
+D L+ ++ Q ++ T + + + +L + +L +L +E+ K++
Sbjct: 1312 KLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQN 1368
Score = 59.7 bits (143), Expect = 1e-08
Identities = 88/431 (20%), Positives = 181/431 (41%), Gaps = 81/431 (18%)
Query: 477 LKAQQKYTNIVKEMKAKDLEIRIHKKKKCEIYRRLREFAKLYDTIRNERNKFVNLLHKAH 536
+K + T +EM+AK+ E++ K+++ KA
Sbjct: 848 VKPLLQVTRQEEEMQAKEDELQKTKERQ----------------------------QKAE 879
Query: 537 QKVNEIKERHKMSLNELEILRNSAVSQERKLQNSMLKHANNVTIRESMQNDVRKIVSKLQ 596
++ E++++H E +L + +LQ +A +R + +++ L
Sbjct: 880 NELKELEQKHSQLTEEKNLL-------QEQLQAETELYAEAEEMRVRLAAKKQELEEILH 932
Query: 597 EMKEKKEAQLNNIDRLANTITMIEEEMVQLRKRYEKAVQHRNESGVQLIEREEEICIFYE 656
EM+ + E + + +L + ++M+ L ++ E+ R + ++ + E +I +
Sbjct: 933 EMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLED 992
Query: 657 KINIQEKMKLNGEIEIHLLEEKIQFLKMKIAEKQRQICVTQKLLPAKRSLDADLAVLQIQ 716
+I + + E LLEE+I L +AE++ + + L K ++ ++ L+++
Sbjct: 993 EILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK---AKNLTKLKNKHESMISELEVR 1049
Query: 717 FSQCTDRIKDLEKQFVKPDGENRARFLPGKDLTEK--EMIQKLDKLELQLAKKEEKLLEK 774
+ ++LEK K +G+ D E+ ++ ++ +L++QLAKKEE+L
Sbjct: 1050 LKKEEKSRQELEKLKRKLEGD-------ASDFHEQIADLQAQIAELKMQLAKKEEEL--- 1099
Query: 775 DFIYEQVSRLTDRLCSKTQGCKQDTLLLAKKMNGY----------QRRIKNATEKMMALV 824
++RL D + K K+ +++ G+ +R +N EK
Sbjct: 1100 ---QAALARLDDEIAQKNNALKK-----IRELEGHISDLQEDLDSERAARNKAEK----- 1146
Query: 825 AELSMKQALTIELQKEVREKEDFIFTCNSRIEKGLPLNKEIEKEWLKVLRDEE--MHALA 882
K+ L EL+ E ED + + ++ E L +E E LK DEE H
Sbjct: 1147 ----QKRDLGEELEALKTELEDTLDSTATQQE--LRAKREQEVTVLKKALDEETRSHEAQ 1200
Query: 883 IAEKSQEFLEA 893
+ E Q+ +A
Sbjct: 1201 VQEMRQKHAQA 1211
Score = 58.9 bits (141), Expect = 2e-08
Identities = 81/455 (17%), Positives = 186/455 (40%), Gaps = 55/455 (12%)
Query: 105 HLQQADNFPEAFSTEVSKMREQLLKYQNEYNAVKEREFHNQYRLNSLKEEKIIIVKEFEK 164
++ + + A T++ +M+ QL + ++E A ++ + + + +LK
Sbjct: 1533 NVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALK------------ 1580
Query: 165 ITKPGEMEKKMKILRESTEELRKEIMQKKLEIKNLREDLASKQKQLLKEQKELEELLGHQ 224
G+ E+ ++ E EE R+++ ++ E + ED ++ +K+LE
Sbjct: 1581 ----GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEG----- 1631
Query: 225 VVLKDEVAHHQTIPVQIGKEIEKITRKKVEMEKKKIVLEQEVKTLNDSLKKVENKVSAIV 284
LKD + +Q I+ ++ K + ++ + L D+ + +++ A
Sbjct: 1632 -DLKD-------LELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDA-RASRDEIFATA 1682
Query: 285 DEKENVIKEVEGKRALLEIKEREHNQLVKLLELARENEATSLTERGILDLNLRNSLID-K 343
E E K +E L+ + K +L +E A L L+ RN+L D K
Sbjct: 1683 KENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELAS----SLSGRNALQDEK 1738
Query: 344 QNYHDELSRKQREKERDFRNLRKMELLLKVSWDALRQTQALHQRLLLEMEAIPKDDSTLS 403
+ +++ + E E + N+ M ++ A +Q + L L E K++S
Sbjct: 1739 RRLEARIAQLEEELEEEQGNMEAMSDRVR---KATQQAEQLSNELATERSTAQKNES--- 1792
Query: 404 ERRRELHKEVEVAKRNLAQQKIISEMESKLVEQQLAEENKLLKEQENMKELVVNLLRMTQ 463
A++ L +Q E+ SKL E + A ++K ++ + L +
Sbjct: 1793 ------------ARQQLERQN--KELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVE 1838
Query: 464 IKIDEKEQKSKDFLKAQQKYTNIVKEMKAKDLEIRIHKKKKCEIYRRLREFAKLYDTIRN 523
+ EK+ +K + +K I+ +++ + +K++ + R+++ + +
Sbjct: 1839 QEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEE 1898
Query: 524 ERNKFVNLLHKAHQKVNEIKERHKMSLNELEILRN 558
E + K ++++E E ++ E+ L++
Sbjct: 1899 ESQRINANRRKLQRELDEATESNEAMGREVNALKS 1933
Score = 52.8 bits (125), Expect = 2e-06
Identities = 95/442 (21%), Positives = 184/442 (41%), Gaps = 98/442 (22%)
Query: 50 LHELHAMGKLPGTRMAALKAKYTLLHDAVMSTQESEVQLLQNAKRFTEQIQ--------Q 101
+HEL + T+M +K + L D + +T++++++L N + Q + Q
Sbjct: 1534 VHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ 1593
Query: 102 QQFHLQQADNFPEAFSTEVSKMREQL----------------LKYQNEYNAVKEREFHNQ 145
+ +Q + TE+ R+Q L+ Q + +A+K RE +
Sbjct: 1594 NEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQAD-SAIKGREEAIK 1652
Query: 146 YRLNSLKEEKIIIVKEFEK--------ITKPGEMEKKMKILRESTEELRKEIM------- 190
+L L+ + +E E E EKK K L +L++++
Sbjct: 1653 -QLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARK 1711
Query: 191 QKKLEIKNLREDLASK--------------QKQLLKEQKELEELLGHQVVLKDEVAHHQT 236
Q LE + L E+LAS + ++ + ++ELEE G+ + D V
Sbjct: 1712 QADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQ 1771
Query: 237 IPVQIGKEI--EKITRKKVEMEKKKIVLEQEVKTLNDSLKKVENKVSAIVDEKENVIKEV 294
Q+ E+ E+ T +K E +++ LE++ K L L ++E A+ + ++ I +
Sbjct: 1772 QAEQLSNELATERSTAQKNESARQQ--LERQNKELRSKLHEME---GAVKSKFKSTIAAL 1826
Query: 295 EGKRALLEIKEREHNQLVKLLELARENEAT--SLTERGILDLNLRNSLIDKQNYHDELSR 352
E K A LE + + ARE +A SL ++ D L+ L+ + DE
Sbjct: 1827 EAKIAQLEEQVEQE---------AREKQAATKSLKQK---DKKLKEILLQVE---DERKM 1871
Query: 353 KQREKERDFRNLRKMELLLKVSWDALRQTQALHQRLLLEMEAIPKDDSTLSERRRELHKE 412
++ KE+ + A ++L ++E ++ ++ RR+L +E
Sbjct: 1872 AEQYKEQ------------------AEKGNARVKQLKRQLEEAEEESQRINANRRKLQRE 1913
Query: 413 V-EVAKRNLAQQKIISEMESKL 433
+ E + N A + ++ ++SKL
Sbjct: 1914 LDEATESNEAMGREVNALKSKL 1935
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 115 bits (287), Expect = 3e-25
Identities = 168/817 (20%), Positives = 346/817 (42%), Gaps = 74/817 (9%)
Query: 114 EAFSTEVSKMREQLLKYQNEYNAVKEREFHNQYRLNSLKEEKIIIVKEFEKITKPGEMEK 173
+A E+ K +E+ K +NE ++++ N L+E+ + E E + EM
Sbjct: 855 QAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ---LQAETELYAEAEEMRV 911
Query: 174 KMKILRESTEELRKEIMQKKLEIKNLREDLASKQKQLLKEQKELEELLGHQVVLKDEVAH 233
++ ++ EE+ E+ + E ++ + L +++K++ ++ +LEE L++E A
Sbjct: 912 RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE------QLEEEEAA 965
Query: 234 HQTIPVQIGKEIEKIT--RKKVEMEKKKIVLEQEVKTLNDSLKKVENKVSAIVDEKENVI 291
Q + ++EK+T K ++E + +V++ + L+ K +E ++S D N+
Sbjct: 966 RQKL------QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERIS---DLTTNLA 1016
Query: 292 KEVEGKRALLEIKEREHNQLVKLLELARENEATSLTERGILDLNLRNSLIDKQNYHDELS 351
+E E + L ++K + H ++ LE+ + E S E L L D ++H++++
Sbjct: 1017 EEEEKAKNLTKLKNK-HESMISELEVRLKKEEKSRQELEKLKRKLEG---DASDFHEQIA 1072
Query: 352 RKQREKERDFRNLRKMELLLKVSWDALRQTQALHQRLLLEMEAIPKDDSTLSE---RRRE 408
Q + L K E L+ + L A L ++ + S L E R
Sbjct: 1073 DLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERA 1132
Query: 409 LHKEVEVAKRNLAQ--QKIISEMESKLVEQQLAEENKLLKEQE--NMKELVVNLLRMTQI 464
+ E KR+L + + + +E+E L +E + +EQE +K+ + R +
Sbjct: 1133 ARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEA 1192
Query: 465 KIDEKEQKSKDFLKAQQKYTNIVKEMKAK-DLEIRIHKKKKCEIYRRLREFAKLYDTIRN 523
++ E QK ++ + K KA D + +K+ ++ LR + + +
Sbjct: 1193 QVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH 1252
Query: 524 ERNKFVNLLHKAHQKVNEIKERHKMSLNELEILRNSAVSQERKLQNSMLKHANNVTIRES 583
++ K + + K ++ ER + LN+ + + E + ML A I+
Sbjct: 1253 KKKKLEAQVQELQSKCSD-GERARAELND----KVHKLQNEVESVTGMLNEAEGKAIK-- 1305
Query: 584 MQNDVRKIVSKLQEMKEKKEAQLNNIDRLANTITMIEEEMVQLRKRYEKAVQ-------H 636
+ DV + S+LQ+ +E + + ++ + +EEE L+ + ++ ++ H
Sbjct: 1306 LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1365
Query: 637 RNESGVQLIEREEEICIFYEKINIQEKMKLNGEIEIHLLEEKIQFLKMKIAEKQRQICVT 696
+ +QL + ++++ F + E+ K + EI L + + + +
Sbjct: 1366 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ----------QYEEKAAAY 1415
Query: 697 QKLLPAKRSLDADLAVLQIQFSQCTDRIKDLEK------QFVKPDGENRARFLPGKDLTE 750
KL K L +L L + + +LEK Q + + +++ +D E
Sbjct: 1416 DKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAE 1475
Query: 751 KEMIQKLDKLELQLAKKEEKLLEKDFIYEQVSRLTDRLCSKTQGCKQDTLLLAKKMNGYQ 810
E +K K L LA+ E+ LE E+ +++ K D ++ +
Sbjct: 1476 AEAREKETK-ALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSK 1534
Query: 811 RRIKNATEKMMALVAELSMKQALT--IELQKEVRE---KEDFIFTCNSRIEKGLPLNKEI 865
R ++ E+M + EL + T +L+ EV K F +R E+ +++
Sbjct: 1535 RALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQL 1594
Query: 866 EK---EWLKVLRDE-EMHALAIAEKSQEFLEADNRQL 898
++ E+ L DE + ALA A K + LE D + L
Sbjct: 1595 QRQLHEYETELEDERKQRALAAAAKKK--LEGDLKDL 1629
Score = 90.5 bits (223), Expect = 7e-18
Identities = 186/894 (20%), Positives = 373/894 (41%), Gaps = 148/894 (16%)
Query: 75 HDAVMSTQESEVQLLQNAKRFTEQIQQQ------QFHLQQADNFPEAFSTEVSKMREQLL 128
H++++S E ++ + +++ E+++++ FH Q AD ++++++ QL
Sbjct: 1032 HESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD-----LQAQIAELKMQLA 1086
Query: 129 KYQNEYNAVKER-EFHNQYRLNSLKEEKIIIVKEFE------------KITKPGEMEKKM 175
K + E A R + + N+LK+ ++E E + + EK+
Sbjct: 1087 KKEEELQAALARLDDEIAQKNNALKK-----IRELEGHISDLQEDLDSERAARNKAEKQK 1141
Query: 176 KILRESTEELRKEIMQKKLEIKNLREDLASKQKQLLKEQKEL--EELLGHQVVLKDEVAH 233
+ L E E L+ E+ + L+ +++L +K++Q + K+ EE H+ +++
Sbjct: 1142 RDLGEELEALKTEL-EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQK 1200
Query: 234 HQTIPVQIGKEIEKITRKKV----------------------------EMEKKKIVLEQE 265
H ++ +++E+ R K E+E KK LE +
Sbjct: 1201 HAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQ 1260
Query: 266 VK--------------TLNDSLKKVENKVSAIVDEKENVIKEVEGKR-ALLEIKEREHNQ 310
V+ LND + K++N+V ++ ++ E EGK L + +Q
Sbjct: 1261 VQELQSKCSDGERARAELNDKVHKLQNEVESVT----GMLNEAEGKAIKLAKDVASLSSQ 1316
Query: 311 LVKLLELARENEATSLTERGILDLNLRNSLIDKQNYHDELSRKQREKERDFRNLRKMELL 370
L EL +E L + LR ++ + D+L + K+ R++ + +
Sbjct: 1317 LQDTQELLQEETRQKLN----VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1372
Query: 371 LKVSWDALRQTQALHQRLLLEMEAIPKDDSTLSERRRELHKEVEVAKRNLAQQKIISEME 430
L S L Q +EA L E ++ KE+E NL QQ E
Sbjct: 1373 LSDSKKKL-------QDFASTVEA-------LEEGKKRFQKEIE----NLTQQ-----YE 1409
Query: 431 SKLVEQQLAEENKLLKEQENMKELVVNLLRMTQIKID-EKEQKSKDFLKAQQK--YTNIV 487
K E+ K +QE + +LVV+L Q+ + EK+Q+ D L A++K +
Sbjct: 1410 EKAAAYDKLEKTKNRLQQE-LDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYA 1468
Query: 488 KEMKAKDLEIRIHKKKKCEIYRRL-------REFAKLYDTIRNERNKFVNLLHKAHQKVN 540
E + E R + K + R L E + ++ E V+ + V+
Sbjct: 1469 DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVH 1528
Query: 541 EIKERHKMSLNELEILRNSAVSQERKLQNSMLKHANNVTIRESMQNDVRKIVSKLQEMKE 600
E+++ + ++E ++ E +LQ + ++++ + + E E
Sbjct: 1529 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1588
Query: 601 KKEAQLNNIDRLANTITMIEEEMVQLRKRYEKAVQHRNESGVQLIEREEEICIFYEKINI 660
+K QL +L T +E+E Q + A + + E ++ +E + + I + I
Sbjct: 1589 EKRRQLQR--QLHEYETELEDERKQ--RALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1644
Query: 661 QEKMKLNGEIEIHLLEEKIQFLKMKIAEKQRQICVTQKLLPAKRSLDADLAVLQ--IQFS 718
++ KL +++ E L+ A + ++ +SL+ADL LQ + +
Sbjct: 1645 KQLRKLQAQMKDFQRE-----LEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAA 1699
Query: 719 QCTDRIKDLEKQFVKPDGENRARFLPGKDLTEKEMIQKLDKLELQLAKKEEKLLEKDFIY 778
+ + DLEK+ + E A L G++ + E +LE ++A+ EE+L E+
Sbjct: 1700 ERARKQADLEKEEL---AEELASSLSGRNALQDEK----RRLEARIAQLEEELEEEQGNM 1752
Query: 779 EQVSRLTDRLCSKTQGCKQDTLLLAKKMNGYQRRIKNATEKMMALVAELSMKQALTIELQ 838
E +S DR+ TQ +Q + LA + + Q+ ++A +++ EL K E++
Sbjct: 1753 EAMS---DRVRKATQQAEQLSNELATERSTAQKN-ESARQQLERQNKELRSK---LHEME 1805
Query: 839 KEVREKEDFIFTCNSRIEKGLPLNKEIEKEWLKVLRDEEMHALAIAEKSQEFLE 892
V+ K F T + K L +++E+E R+++ ++ +K ++ E
Sbjct: 1806 GAVKSK--FKSTIAALEAKIAQLEEQVEQE----AREKQAATKSLKQKDKKLKE 1853
Score = 83.6 bits (205), Expect = 8e-16
Identities = 125/671 (18%), Positives = 272/671 (40%), Gaps = 60/671 (8%)
Query: 4 SSTDTEKEEEEEKDEKDQEPIYAIVPTINIQDERFVDLSETPAFI---------FLHELH 54
S + + E +K K Q + ++ +N + + + L++ A + L E
Sbjct: 1269 SDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEET 1328
Query: 55 AMGKLPGTRMAALKAKYTLLHDAVMSTQESEVQLLQNAKRFTEQIQQQQFHLQQADNFPE 114
T++ L+ + L D + E++ L ++ Q+ + LQ + E
Sbjct: 1329 RQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVE 1388
Query: 115 A-------FSTEVSKMREQLLKYQNEYNAVKEREFHNQYRLNSLK---EEKIIIVKEFEK 164
A F E+ + +Q + Y+ +++ + Q L+ L + + +V EK
Sbjct: 1389 ALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEK 1448
Query: 165 ITKPGEM---EKKMKILRESTEELRKEIMQKKLEIKNLREDLASKQKQLLKEQKELEELL 221
+ + E+K + + E R E ++ E K L LA ++ L+ ++ELE
Sbjct: 1449 KQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL--SLARALEEALEAKEELERT- 1505
Query: 222 GHQVVLKDEVAHHQTIPVQIGKEIEKITRKKVEMEKKKIVLEQEVKTLNDSLKKVENKVS 281
+LK E+ + +GK + E+EK K LE +++ + L+++E+++
Sbjct: 1506 --NKMLKAEMEDLVSSKDDVGKNVH-------ELEKSKRALETQMEEMKTQLEELEDELQ 1556
Query: 282 AIVDEK---ENVIKEVEGK-----RALLEIKEREHNQLVKLL---ELARENEATSLTERG 330
A D K E ++ ++G+ +A E E + QL + L E E+E
Sbjct: 1557 ATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAA 1616
Query: 331 ILDLNLRNSLIDKQNYHDELSRKQREKERDFRNLRKMELLLKVSWDALRQTQALHQRLLL 390
L L D + D + + E + LRK++ +K L +A +
Sbjct: 1617 AAKKKLEGDLKDLELQADSAIKGREEA---IKQLRKLQAQMKDFQRELEDARASRDEIFA 1673
Query: 391 EMEAIPKDDSTLSERRRELHKEVEVAKRNLAQQKIISEMESKLVEQQLAEENKLLKEQEN 450
+ K +L +L +++ A+R Q + E ++ + L+ N L E+
Sbjct: 1674 TAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRR 1733
Query: 451 MKELVVNLLRMTQIKIDEKEQKSKDFLKAQQKYTNIVKEMKAKDLEIRIHKKKKCEIYRR 510
++ + L + + E S KA Q+ + E+ + + ++ + ++ R+
Sbjct: 1734 LEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQ 1793
Query: 511 LREF-AKLYDTIRNERNKFVNLLHKAHQKVNEIKERHKMSLNELEILRNSAVSQERKLQN 569
+E +KL++ ++KF + + K+ +++E+ + E + S +++KL+
Sbjct: 1794 NKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKE 1853
Query: 570 SMLKHANNVTIRESMQNDVRKIVSKLQEMKEKKEAQLNNIDRLANTITMIEEEMVQLRKR 629
+L+ D RK+ + +E EK A++ + R + + R++
Sbjct: 1854 ILLQ-----------VEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRK 1902
Query: 630 YEKAVQHRNES 640
++ + ES
Sbjct: 1903 LQRELDEATES 1913
Score = 80.9 bits (198), Expect = 5e-15
Identities = 119/597 (19%), Positives = 261/597 (43%), Gaps = 99/597 (16%)
Query: 263 EQEVKTLNDSLKKVENKVSAIVDEKENVIKEVEGKRA-LLEIKEREHNQLVKLLELAREN 321
E+E++ D L+K + + + EN +KE+E K + L E K QL EL E
Sbjct: 851 EEEMQAKEDELQKTKERQQ----KAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 906
Query: 322 EATSLTERGILDLNLRNSLIDKQNYHDELSRKQREKERDFRNLRKMELLLKVSWDALRQT 381
E ++ +R L+ K++E E L +ME L+ D +Q
Sbjct: 907 E----------EMRVR------------LAAKKQELEEI---LHEMEARLEEEEDRGQQL 941
Query: 382 QALHQRLLLEMEAIPKDDSTLSERRRELHKEVEVAKRNLAQQKIISEMESKLVEQQLA-- 439
QA +++ +M + E +E E A++ L +K+ +E + K +E ++
Sbjct: 942 QAERKKMAQQMLDL-----------EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVM 990
Query: 440 --EENKLLKEQENMKELVVNLLRMTQIKIDEKEQKSKDFLKAQQKYTNIVKEMKAKDLEI 497
+ NKL KE++ ++E + +L + E+E+K+K+ K + K+ +++ E LE+
Sbjct: 991 DDQNNKLSKERKLLEERISDLTT----NLAEEEEKAKNLTKLKNKHESMISE-----LEV 1041
Query: 498 RIHKKKKCEIYRRLREFAKLYDTIRNERNKFVNLLHKAHQKVNEIKERHKMSLNELEILR 557
R+ K++K +E KL + + + F H+++ +++ ++ L+
Sbjct: 1042 RLKKEEKSR-----QELEKLKRKLEGDASDF-------HEQIADLQA-------QIAELK 1082
Query: 558 NSAVSQERKLQNSMLKHANNVTIRESMQNDVRKI---VSKLQEMKEKKEAQLNNIDRLAN 614
+E +LQ ++ + + + + + +R++ +S LQE + + A N ++
Sbjct: 1083 MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1142
Query: 615 TITMIEEEMVQLRKRYEKAVQHRNESGVQLIEREEEICIFYEKINIQEKMKLNGEIEIHL 674
+ EE+ L+ E + +RE+E+ + K L+ E H
Sbjct: 1143 D---LGEELEALKTELEDTLDSTATQQELRAKREQEVTVL--------KKALDEETRSH- 1190
Query: 675 LEEKIQFLKMKIAEKQRQIC-VTQKLLPAKRSLDADLAVLQIQFSQCTDRIKDLEKQFVK 733
E ++Q ++ K A+ ++ ++ AK +LD + L+ + + ++ L + K
Sbjct: 1191 -EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ--AK 1247
Query: 734 PDGENRARFLPGKDLTEKEMIQKLDKLELQLAKKEEKLLEKDFIYEQVSRLTDRLCSKTQ 793
+ E++ + L + +E+ K E A+ +K+ + E V+ + + K
Sbjct: 1248 QEVEHKKKKL---EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAI 1304
Query: 794 GCKQDTLLLAKKMNGYQRRIKNATEKMMALVAELSM----KQALTIELQKEVREKED 846
+D L+ ++ Q ++ T + + + +L + +L +L +E+ K++
Sbjct: 1305 KLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQN 1361
Score = 59.7 bits (143), Expect = 1e-08
Identities = 88/431 (20%), Positives = 181/431 (41%), Gaps = 81/431 (18%)
Query: 477 LKAQQKYTNIVKEMKAKDLEIRIHKKKKCEIYRRLREFAKLYDTIRNERNKFVNLLHKAH 536
+K + T +EM+AK+ E++ K+++ KA
Sbjct: 841 VKPLLQVTRQEEEMQAKEDELQKTKERQ----------------------------QKAE 872
Query: 537 QKVNEIKERHKMSLNELEILRNSAVSQERKLQNSMLKHANNVTIRESMQNDVRKIVSKLQ 596
++ E++++H E +L + +LQ +A +R + +++ L
Sbjct: 873 NELKELEQKHSQLTEEKNLL-------QEQLQAETELYAEAEEMRVRLAAKKQELEEILH 925
Query: 597 EMKEKKEAQLNNIDRLANTITMIEEEMVQLRKRYEKAVQHRNESGVQLIEREEEICIFYE 656
EM+ + E + + +L + ++M+ L ++ E+ R + ++ + E +I +
Sbjct: 926 EMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLED 985
Query: 657 KINIQEKMKLNGEIEIHLLEEKIQFLKMKIAEKQRQICVTQKLLPAKRSLDADLAVLQIQ 716
+I + + E LLEE+I L +AE++ + + L K ++ ++ L+++
Sbjct: 986 EILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK---AKNLTKLKNKHESMISELEVR 1042
Query: 717 FSQCTDRIKDLEKQFVKPDGENRARFLPGKDLTEK--EMIQKLDKLELQLAKKEEKLLEK 774
+ ++LEK K +G+ D E+ ++ ++ +L++QLAKKEE+L
Sbjct: 1043 LKKEEKSRQELEKLKRKLEGD-------ASDFHEQIADLQAQIAELKMQLAKKEEEL--- 1092
Query: 775 DFIYEQVSRLTDRLCSKTQGCKQDTLLLAKKMNGY----------QRRIKNATEKMMALV 824
++RL D + K K+ +++ G+ +R +N EK
Sbjct: 1093 ---QAALARLDDEIAQKNNALKK-----IRELEGHISDLQEDLDSERAARNKAEK----- 1139
Query: 825 AELSMKQALTIELQKEVREKEDFIFTCNSRIEKGLPLNKEIEKEWLKVLRDEE--MHALA 882
K+ L EL+ E ED + + ++ E L +E E LK DEE H
Sbjct: 1140 ----QKRDLGEELEALKTELEDTLDSTATQQE--LRAKREQEVTVLKKALDEETRSHEAQ 1193
Query: 883 IAEKSQEFLEA 893
+ E Q+ +A
Sbjct: 1194 VQEMRQKHAQA 1204
Score = 58.9 bits (141), Expect = 2e-08
Identities = 81/455 (17%), Positives = 186/455 (40%), Gaps = 55/455 (12%)
Query: 105 HLQQADNFPEAFSTEVSKMREQLLKYQNEYNAVKEREFHNQYRLNSLKEEKIIIVKEFEK 164
++ + + A T++ +M+ QL + ++E A ++ + + + +LK
Sbjct: 1526 NVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALK------------ 1573
Query: 165 ITKPGEMEKKMKILRESTEELRKEIMQKKLEIKNLREDLASKQKQLLKEQKELEELLGHQ 224
G+ E+ ++ E EE R+++ ++ E + ED ++ +K+LE
Sbjct: 1574 ----GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEG----- 1624
Query: 225 VVLKDEVAHHQTIPVQIGKEIEKITRKKVEMEKKKIVLEQEVKTLNDSLKKVENKVSAIV 284
LKD + +Q I+ ++ K + ++ + L D+ + +++ A
Sbjct: 1625 -DLKD-------LELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDA-RASRDEIFATA 1675
Query: 285 DEKENVIKEVEGKRALLEIKEREHNQLVKLLELARENEATSLTERGILDLNLRNSLID-K 343
E E K +E L+ + K +L +E A L L+ RN+L D K
Sbjct: 1676 KENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELAS----SLSGRNALQDEK 1731
Query: 344 QNYHDELSRKQREKERDFRNLRKMELLLKVSWDALRQTQALHQRLLLEMEAIPKDDSTLS 403
+ +++ + E E + N+ M ++ A +Q + L L E K++S
Sbjct: 1732 RRLEARIAQLEEELEEEQGNMEAMSDRVR---KATQQAEQLSNELATERSTAQKNES--- 1785
Query: 404 ERRRELHKEVEVAKRNLAQQKIISEMESKLVEQQLAEENKLLKEQENMKELVVNLLRMTQ 463
A++ L +Q E+ SKL E + A ++K ++ + L +
Sbjct: 1786 ------------ARQQLERQN--KELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVE 1831
Query: 464 IKIDEKEQKSKDFLKAQQKYTNIVKEMKAKDLEIRIHKKKKCEIYRRLREFAKLYDTIRN 523
+ EK+ +K + +K I+ +++ + +K++ + R+++ + +
Sbjct: 1832 QEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEE 1891
Query: 524 ERNKFVNLLHKAHQKVNEIKERHKMSLNELEILRN 558
E + K ++++E E ++ E+ L++
Sbjct: 1892 ESQRINANRRKLQRELDEATESNEAMGREVNALKS 1926
Score = 52.8 bits (125), Expect = 2e-06
Identities = 95/442 (21%), Positives = 184/442 (41%), Gaps = 98/442 (22%)
Query: 50 LHELHAMGKLPGTRMAALKAKYTLLHDAVMSTQESEVQLLQNAKRFTEQIQ--------Q 101
+HEL + T+M +K + L D + +T++++++L N + Q + Q
Sbjct: 1527 VHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ 1586
Query: 102 QQFHLQQADNFPEAFSTEVSKMREQL----------------LKYQNEYNAVKEREFHNQ 145
+ +Q + TE+ R+Q L+ Q + +A+K RE +
Sbjct: 1587 NEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQAD-SAIKGREEAIK 1645
Query: 146 YRLNSLKEEKIIIVKEFEK--------ITKPGEMEKKMKILRESTEELRKEIM------- 190
+L L+ + +E E E EKK K L +L++++
Sbjct: 1646 -QLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARK 1704
Query: 191 QKKLEIKNLREDLASK--------------QKQLLKEQKELEELLGHQVVLKDEVAHHQT 236
Q LE + L E+LAS + ++ + ++ELEE G+ + D V
Sbjct: 1705 QADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQ 1764
Query: 237 IPVQIGKEI--EKITRKKVEMEKKKIVLEQEVKTLNDSLKKVENKVSAIVDEKENVIKEV 294
Q+ E+ E+ T +K E +++ LE++ K L L ++E A+ + ++ I +
Sbjct: 1765 QAEQLSNELATERSTAQKNESARQQ--LERQNKELRSKLHEME---GAVKSKFKSTIAAL 1819
Query: 295 EGKRALLEIKEREHNQLVKLLELARENEAT--SLTERGILDLNLRNSLIDKQNYHDELSR 352
E K A LE + + ARE +A SL ++ D L+ L+ + DE
Sbjct: 1820 EAKIAQLEEQVEQE---------AREKQAATKSLKQK---DKKLKEILLQVE---DERKM 1864
Query: 353 KQREKERDFRNLRKMELLLKVSWDALRQTQALHQRLLLEMEAIPKDDSTLSERRRELHKE 412
++ KE+ + A ++L ++E ++ ++ RR+L +E
Sbjct: 1865 AEQYKEQ------------------AEKGNARVKQLKRQLEEAEEESQRINANRRKLQRE 1906
Query: 413 V-EVAKRNLAQQKIISEMESKL 433
+ E + N A + ++ ++SKL
Sbjct: 1907 LDEATESNEAMGREVNALKSKL 1928
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 115 bits (287), Expect = 3e-25
Identities = 155/837 (18%), Positives = 369/837 (44%), Gaps = 84/837 (10%)
Query: 123 MREQLLKYQNEYNAVKEREFHNQYRLNSLKEEKIIIVKEFEKITKPGE-MEKKMKILRES 181
+ +L + ++E +++ + + L ++ EK+ + K+ E K +E+++ ++
Sbjct: 1900 VENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSE 1959
Query: 182 TEELRKEI---MQKKLEIKNLREDLASKQKQLLKEQKELEELLGHQVVLKDEVAHHQTIP 238
+LR E+ +K + L E + K ++L Q E + V + EV +
Sbjct: 1960 RNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQ---VAEAEVKEKTELL 2016
Query: 239 VQIGKEIEKITRKKVEMEKKKIVLEQEVKTLNDSLKKVENKVSAIVDEKENVIKEVEGKR 298
+ ++ ++ + K +++K LE++ + L+ + ++EN+++ + EKE ++KE E +
Sbjct: 2017 QTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQ 2076
Query: 299 ALLEIKEREHNQLVKLLE------------LARENEATSLTERGILDLNLRNSLIDKQNY 346
A L + E + K LE L+ E RGI L +R +K+
Sbjct: 2077 ARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQL 2136
Query: 347 HDELSRKQREKERD-----FRNLRK--------MELLLKVSWDALRQTQALH---QRLLL 390
H K+RE+E D NL + EL++ + ++ + + L + +
Sbjct: 2137 HIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMAR 2196
Query: 391 EMEAIPKDDSTLSERRRELHKEVEVAKRNLAQ-QKIISEMESKLVEQ-----QLAEENKL 444
++ D TL + L K+++ + L++ K++S +S L E+ Q+ EE+K
Sbjct: 2197 SLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKT 2256
Query: 445 LKE--QENMKEL--VVNLLRMTQIKIDEKEQKSKDFLKAQQKYTNIVKEMKAKDLEIRIH 500
E Q +KEL V L Q + EQ ++ + + N +++++A+ +
Sbjct: 2257 AVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRAR---LEAD 2313
Query: 501 KKKKCEIYRRLREFAKLYDTIRNERNKFVNLLHKAHQKVNEIKERHKMSLNELEILRNSA 560
+KK+ + ++L+E D ++ L A + S E+E L+
Sbjct: 2314 EKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKI 2373
Query: 561 VSQERKLQNSMLKHANNVTIRESMQNDVRKIVSKLQE-----------MKEKKEAQLNNI 609
+ L+ L + +E++ N+++K ++ E ++EK++ ++
Sbjct: 2374 EGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMK 2433
Query: 610 DRLANTITMIEEEMVQLRKRYEKAVQHRNESGVQLIEREEEICIFYEKINIQEKMKLNG- 668
++ + + M++ ++ +L +R A H ++ + +E+ + E + +++ L G
Sbjct: 2434 EKSSTAMEMLQTQLKELNERV--AALHNDQEACK--AKEQNLSSQVECLELEKAQLLQGL 2489
Query: 669 ----------EIEIHLLEEKIQFLKMKIAEKQRQICVTQKLLPAKRSLDADLAVLQIQFS 718
+ ++ L ++++ K K+ +K +I + + + L + L+ Q++
Sbjct: 2490 DEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLS--QVEGE 2547
Query: 719 QCTDRIKDLEKQFVKPDGENRARFLPGKDLTEKEMIQKLDKLELQLAKK-EEKLLEKDFI 777
+ ++LE + + + E + + L K+ + ++ ++ L L + E ++K
Sbjct: 2548 HQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSF 2607
Query: 778 YEQVSRLTDR---LCSKTQGCKQDTLLLAKKMNGYQRRIKNATEKMMALVAELSMKQALT 834
E+V+++T + L + Q T L ++++G + R+ ++ L+ E+ +
Sbjct: 2608 VEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAG---ELQLLLEEIKSSKDQL 2664
Query: 835 IELQKEVRE-KEDFIFTCNSRIEKGLPLNKEIEKEWLKVLRDEEMHALAIAEKSQEF 890
EL E E K+ ++EK + +EI + L++ E+ H + + ++++
Sbjct: 2665 KELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQY 2721
Score = 102 bits (254), Expect = 2e-21
Identities = 172/878 (19%), Positives = 359/878 (40%), Gaps = 131/878 (14%)
Query: 67 LKAKYTLLHDAVMSTQESEVQLLQNAKRFTEQIQQQQFHLQQADNFPEAFSTEVSKM--- 123
+ K T L +E +L + IQ + +++ + S++VS++
Sbjct: 1970 MSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKD 2029
Query: 124 ----REQLLKYQNEYNAVKEREFHNQYRLNSLKEEKIIIVKEFE---------------- 163
+E+L + + A+ + + ++ L +EK ++VKE E
Sbjct: 2030 KTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNV 2089
Query: 164 -KITKPGEMEKKMKILRESTEELRKEIMQKKLEIKNLREDLASKQKQLLKEQKELEELLG 222
K + +EK LR S+ + +E+ Q + I+ LR + + +K+ L ++L+E
Sbjct: 2090 SKALEAALVEKGEFALRLSSTQ--EEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERER 2147
Query: 223 HQVVLKDEVAHHQTIPVQIGKEIEKITRKKVEMEKKKI-VLEQEVKTLNDSLKKVENKVS 281
LKD+V + + +Q+ +E +++ E K ++ L+ +++ + SLK E +
Sbjct: 2148 ENDSLKDKVENLER-ELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLV 2206
Query: 282 AIVDEKENVIKEVEGKRALLEIKEREHNQLVKLLELARENEATSLTERGILDLNLRNSLI 341
+ EKEN+ K+++ K+ L ++ + LLE + E E L+N L
Sbjct: 2207 TLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLK 2266
Query: 342 DKQNYHDELSRKQR-------------EKERDFRNLRKMELLLKVSWDALRQTQALHQRL 388
+ L Q E+E RN + +L ++ D +Q L Q
Sbjct: 2267 ELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIE-KLRARLEADEKKQLCVLQQLK 2325
Query: 389 LLEMEAIPKDDSTLSERRRELHKEVEVAKRNLAQQKIISEMESKLVEQQLAE-------- 440
E A L R L +E+E+A+ N + +E VE A+
Sbjct: 2326 ESEHHA-----DLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSL 2380
Query: 441 -----------------ENKLLKEQENMKELVV------NLLR---MTQIKIDEKEQKSK 474
N+L KEQE + EL + N+L+ ++++ EK +
Sbjct: 2381 RGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAM 2440
Query: 475 DFLKAQQK--------YTNIVKEMKAKD----LEIRIHKKKKCEIYRRLREFAKLYDTIR 522
+ L+ Q K N + KAK+ ++ + +K ++ + L E Y ++
Sbjct: 2441 EMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQ 2500
Query: 523 NERNKFVNLLHKAHQKVNEIKERHKMSLNELE-----ILRNSAVSQERKLQNSMLKHANN 577
+ N + + QK+ + E N+++ + + S V E +L N
Sbjct: 2501 SSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRN 2560
Query: 578 VTIRESMQNDVRKIVSKLQEMKEKKEAQLNNIDRLANTITMIEEEMVQLRKRYEKAVQHR 637
+T+ ++ ++ + SK +++ E ++ L N + + + + + ++ K
Sbjct: 2561 LTV--ELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKE 2618
Query: 638 NESGVQLIEREEEICIFYEKINIQEKMKLNGEIEIHLLE-----EKIQFLKMKIAEKQRQ 692
E ++ E ++ E+++ EK +L GE+++ L E ++++ L ++ +E ++
Sbjct: 2619 TELQREMHEMAQKTAELQEELS-GEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKS 2677
Query: 693 I-CVTQKLLPAKRSLDADLAVLQIQFSQCTDR----IKDLEKQFVKPDGENRARFLPGKD 747
+ C+ + + + + ++A Q++ + + + D KQ+ R +
Sbjct: 2678 LDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREK------ 2731
Query: 748 LTEKEMIQKLDKLELQLAKKEEKLLEKDFIYEQVSRLTDRLCSKTQGCKQDTLLLAKKMN 807
LT KE KLE+ L K ++ L + T ++ + + K D L K +N
Sbjct: 2732 LTSKEECLSSQKLEIDLLKSSKEELNNSL------KATTQILEELKKTKMDNL---KYVN 2782
Query: 808 GYQRRIKNATEKMMALVAELSMKQALTIELQKEVREKE 845
++ + A KM L+ K +E +KE+ +KE
Sbjct: 2783 QLKKENERAQGKMKLLI-----KSCKQLEEEKEILQKE 2815
Score = 99.4 bits (246), Expect = 1e-20
Identities = 174/894 (19%), Positives = 378/894 (42%), Gaps = 119/894 (13%)
Query: 80 STQESEVQLLQNAKRFTEQIQQQQFHLQQADNFPEAFSTEVSKMREQLLKYQNEYNAVKE 139
S Q + + +Q R T++ LQQA N E+ K+ + +N K+
Sbjct: 406 SFQTLDQECIQMKARLTQE-------LQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQ 458
Query: 140 REFHNQYRLNSLKEEKIIIVKEFEKITKPGEMEKKMKILRESTEELRKEIMQKKLEIKNL 199
+ + + + +KE E EM+K+ +L+ +E+ +E+ + E+KN+
Sbjct: 459 KLCRAEQAFQASQ------IKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNI 512
Query: 200 REDLASKQKQLLKEQKELEELLGHQVVLKD--EVAHHQTIPVQIGK------EIEKITRK 251
++ L Q Q E+ + + + +L+D E + Q + + K ++EK
Sbjct: 513 KQCL--NQSQNFAEEMKAKN-TSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDC 569
Query: 252 KVEMEKKKIVLEQEVKTLNDSLKKVENKVSAI---VDEKENVIKEVEGKRALLEIKEREH 308
++ KK+ E ++ LND L K E + A+ ++ K+ +E++ ++ L + E+
Sbjct: 570 SQDLLKKR---EHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSEN 626
Query: 309 NQLVKLLELARENEATSLTERGILDLNLRNSLIDKQNYHDELSRKQREKERDFRNLRKME 368
+L+ +E +EN + + L+ L+ I Y++ + + ++E +R +
Sbjct: 627 EKLLTQMESEKENLQSKINH---LETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLH 683
Query: 369 LLLKVSWDALRQTQALHQRLLLEMEAIPKDDSTLSERRRELHKEVEVAKRNLAQQKIISE 428
+L ++ + + L ME K + + + ++E+ + + + L Q E
Sbjct: 684 NVLD------SKSVEVETQKLAYMELQQKAEFSDQKHQKEI-ENMCLKTSQLTGQVEDLE 736
Query: 429 MESKLVEQQLAEENKLLKEQENMKELVVNLLRMTQIKIDEKEQKSKDFLKAQQK------ 482
+ +L+ ++ ++++ ++ E + +LL+ + E + L Q+
Sbjct: 737 HKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHS 796
Query: 483 YTNIVKE---MKAKDLEIRIHKKKKCEIYRRLREFAKLYDTIRNERNKFVNLLHKAHQKV 539
+ NI+ E M ++ E R+ + + L+ + + + + L K +++
Sbjct: 797 FANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEEL 856
Query: 540 NEIKERHKMSLNELEILRNSAVSQE----RKLQNSMLKHAN----NVTIRESMQNDVRKI 591
+IK + +L + E + S V++ KLQ H N ++ E+ + +++ +
Sbjct: 857 VQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLL 916
Query: 592 VSK-------LQEMKEKK---EAQLNNIDRLANTITMIEEEM---VQLRKR-YEKAVQHR 637
K +QE+K+ E L + L+ T+++ ++EM + L KR E+ Q
Sbjct: 917 NDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQEN 976
Query: 638 ----------NESGVQLIEREEEICIFYEKINIQEKMKLNGEIEIHLLEEKIQFLKMKIA 687
N+ + LI++ E + I E+ K E+ +EK+ L+
Sbjct: 977 GTLKEINASLNQEKMNLIQKSESFANY-----IDEREKSISELSDQYKQEKLILLQRCEE 1031
Query: 688 EKQRQICVTQKLLPAKRSLDADLAVLQIQFSQCTDRIKDLEKQFVKPDGENRARFLPGKD 747
++QK A+ +L S C +R +LE+ K+
Sbjct: 1032 TGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQL---------------KE 1076
Query: 748 LTEKEMIQKLDKLELQLAKKEEKLLEKDFIYEQV-SRLTD---RLCSKTQGCKQDTLLLA 803
KE + L KL + + +LE + + + + S +TD S+ G KQ+ + L
Sbjct: 1077 AFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLK 1136
Query: 804 KKMNGYQRRIKNATEKMMALVAELSMK---QALTIE-LQKEVREKEDFIFTCNSRIEKGL 859
++ N Q+ + + ++ L+ + K Q L E ++ V+E+E CN + + L
Sbjct: 1137 EEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDL 1196
Query: 860 PLNKEIEKEWLK--------VLRDEEMHALAIAEKSQEFLEADNRQLPNGVYTT 905
+ KEI + +LR++E+ L +EK +E L+ + + + + T+
Sbjct: 1197 EV-KEISLDSYNAQLVQLEAMLRNKEL-KLQESEKEKECLQHELQTIRGDLETS 1248
Score = 90.9 bits (224), Expect = 5e-18
Identities = 163/762 (21%), Positives = 318/762 (41%), Gaps = 118/762 (15%)
Query: 86 VQLLQNAKRFTEQIQQQQFHLQQADNFPEAFSTEVSKMREQLLKYQNEYNAVKEREFHNQ 145
V L + T+QIQ++Q L + D +F + + + K Q E +E + +
Sbjct: 2206 VTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEE------KEQAEIQIKEESKTAVE 2259
Query: 146 YRLNSLKEEKIIIVKEFEKITKPGEMEKKMKILRESTEELRKEIMQKKLEIKNLREDLAS 205
N LKE E + ++ MK +S + +E Q + I+ LR L +
Sbjct: 2260 MLQNQLKELN-------EAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEA 2312
Query: 206 KQKQLLKEQKELEELLGHQVVLKDEVAHHQTIPVQIGKEIEKITRKKVEMEKKKI-VLEQ 264
+K+ L ++L+E H +LK V + + ++I + ++ + E K ++ L+
Sbjct: 2313 DEKKQLCVLQQLKESEHHADLLKGRVENLER-ELEIARTNQEHAALEAENSKGEVETLKA 2371
Query: 265 EVKTLNDSLKKVENKVSAIVDEKENVIKEVEGKRALLEIKEREHNQLVKLLELARENEAT 324
+++ + SL+ +E V I EKEN+ E++ ++ + E ++ +L+ +E E
Sbjct: 2372 KIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQ-EKEQEKV 2430
Query: 325 SLTERGILDLNLRNSLIDKQNYHDELSRKQREKERDFRNLRKMELLLKVSWDALRQTQAL 384
+ E+ + + Q EL+ + D + E L + L +A
Sbjct: 2431 QMKEKSSTAMEM------LQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKA- 2483
Query: 385 HQRLLLEMEAIPKDDSTLSERRRELHKEVEVAKRNLAQQ-KIISEMESKLVEQ------- 436
+LL ++ + L L +EVE K+ L ++ + IS +++++ +Q
Sbjct: 2484 --QLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKL 2541
Query: 437 -QLAEENKLLKEQE-NMKELVVNLLRMTQIKIDEKEQKSKDFLKA-QQKYTNIVKEMKAK 493
Q+ E++L KEQ ++ L V L + Q+ + K +D L+ Q Y N+ E++
Sbjct: 2542 SQVEGEHQLWKEQNLELRNLTVELEQKIQV-LQSKNASLQDTLEVLQSSYKNLENELELT 2600
Query: 494 DLE-------IRIHKKKKCEIYRRLREF----AKLYDTIRNERNKFVNLLHKAHQKVNEI 542
++ + K+ E+ R + E A+L + + E+N+ L +++
Sbjct: 2601 KMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSS 2660
Query: 543 KERHKMSLNELEILRNSAVSQERKLQNSMLK------HANNVTIRESMQNDVRKIVSKLQ 596
K++ K E L+NS LK H + V ++ ++ + +L
Sbjct: 2661 KDQLK----------------ELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLH 2704
Query: 597 EMKEKKEAQLNNIDRLANTITMIEEEMVQLRKRYEKAVQHRNESGVQLIEREEEICIFYE 656
E ++K +A L + K+YE +Q E +L +EE C+ +
Sbjct: 2705 EAEKKHQALL-----------------LDTNKQYEVEIQTYRE---KLTSKEE--CLSSQ 2742
Query: 657 KINI----QEKMKLNGEIE--IHLLEE-------KIQFLKMKIAEKQRQICVTQKLLPAK 703
K+ I K +LN ++ +LEE ++++ E +R + L+ +
Sbjct: 2743 KLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSC 2802
Query: 704 RSLDADLAVLQIQFSQCTDRIKDLEKQFVKPDGENRARFLPGKDLTE------KEMIQKL 757
+ L+ + +LQ + SQ ++ +K D + K+L E KE + L
Sbjct: 2803 KQLEEEKEILQKELSQ-LQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYL 2861
Query: 758 DKLELQLAKKEEKLLEKDFIYEQVSRLTDRLCSKTQGCKQDT 799
DK L E+ K+ + QV+ LCS Q KQD+
Sbjct: 2862 DKYCSLLISHEKLEKAKEMLETQVA----HLCS--QQSKQDS 2897
Score = 81.6 bits (200), Expect = 3e-15
Identities = 149/728 (20%), Positives = 296/728 (40%), Gaps = 131/728 (17%)
Query: 198 NLREDLASKQKQLLKEQKELE-ELLGHQVVLKDEVAHHQTIPVQIGK-EIEKITRKKV-- 253
+L + L ++ ++L + ELE L GH+ +K +V Q + +Q+ K ++E I ++KV
Sbjct: 278 HLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLN 337
Query: 254 --------------EMEKKKIVLEQEVKTLNDSLKKVENKVSAIVDEKENVIKEVEGKRA 299
+ K LEQ++K L + L + E IKE
Sbjct: 338 KCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKE------ 391
Query: 300 LLEIKEREHNQLVKLLELARENEATSLTERGILDLNLR--NSLIDKQNYHD----ELSRK 353
KE+E + EL+R+ + ++ + + R L +N H+ EL +
Sbjct: 392 ----KEKEFQE-----ELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKL 442
Query: 354 QREKERDFRNLRKMELLLKVSWDALRQTQALHQRLLLEMEAIPKDDSTLSERRRELHKEV 413
K++ NL + + L + A + +Q L ME + K+++ L + +EV
Sbjct: 443 TSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREV 502
Query: 414 ---EVAKRNLAQ-----QKIISEMESKLVEQQ--LAEENKLLKEQENMKELVVNLLRMTQ 463
E +N+ Q Q EM++K Q+ L + + + +QEN L + L++
Sbjct: 503 CHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQEN--SLTLEKLKLAV 560
Query: 464 IKIDEKEQKSKDFLKAQQ--------KYTNIVKEMKAKDLEIRIHKKKKCEIYRRLREFA 515
++++ S+D LK ++ K + KE KA + + KK+ Y L+E
Sbjct: 561 ADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKE----YEELKEEK 616
Query: 516 KLYDTIRNERNKFVNLLHKAHQKVNEIKERHKMSLNELEILRNSAVSQERKLQNSMLKHA 575
L+ ++E K + ++ KE + +N LE L+ +K
Sbjct: 617 TLFSCWKSENEKLLT-------QMESEKENLQSKINHLETC----------LKTQQIK-- 657
Query: 576 NNVTIRESMQNDVRKIVSKLQEMKEKKEAQLNNIDRLANTITMIEEEMVQLRKRYEKAVQ 635
++ + V L+ +E ++ N+ + ++ + V+ +K +Q
Sbjct: 658 ---------SHEYNERVRTLEMDRENLSVEIRNLHNVLDS----KSVEVETQKLAYMELQ 704
Query: 636 HRNESGVQLIERE-EEICIFYEKINIQEKMKLNGEIEIHLLEEKIQFLKMKIAEKQRQI- 693
+ E Q ++E E +C+ + +L G++E LE K+Q L +I +K R
Sbjct: 705 QKAEFSDQKHQKEIENMCL--------KTSQLTGQVED--LEHKLQLLSNEIMDKDRCYQ 754
Query: 694 ---CVTQKLLPAKRSLDADLAVLQ------IQFSQCT----DRIKDLEKQFVKPDGENRA 740
+ L +S DA L + + F Q + +Q P +
Sbjct: 755 DLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSEC 814
Query: 741 RFLPGKDLTEKEMIQ-KLDKLELQLAKKEEKLLEKDFIYEQVSRLTDRLCSKTQGCKQDT 799
R + ++Q ++D LE L + +K + D + +Q L + +G ++
Sbjct: 815 RLEADQSPKNSAILQNRVDSLEFSL--ESQKQMNSD-LQKQCEELV-----QIKGEIEEN 866
Query: 800 LLLAKKMNGYQRRIKNATEKMMALVAELSMKQALTIELQKEVREKEDFIFTCNSRIEKGL 859
L+ A++M +Q + ++++ L + S Q + E + KE + N ++E
Sbjct: 867 LMKAEQM--HQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQ 924
Query: 860 PLNKEIEK 867
+E++K
Sbjct: 925 AEIQELKK 932
Score = 76.6 bits (187), Expect = 1e-13
Identities = 173/887 (19%), Positives = 364/887 (41%), Gaps = 152/887 (17%)
Query: 67 LKAKYTLLHDAVMSTQESEVQLLQNAKRFTEQIQQ-QQFHLQQADNFPEAFSTE--VSKM 123
LKA+ L + + E E++L + K Q+ + Q+ LQ E E ++K
Sbjct: 283 LKAQNQELRNKI---NELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKC 339
Query: 124 REQLLKYQNEYNAVKEREFHNQYRLNSLKE----------------EKIIIVKEFEKITK 167
R++L++ +Y+ + + +L L E E+ I KE E +
Sbjct: 340 RDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEE 399
Query: 168 PGEMEKKMKILRESTEELRKEIMQKKLEIKNLREDLASKQKQLLKEQKELEELLGH--QV 225
++ + L + +++ + Q+ + KN+ L ++ +L +++LE L Q
Sbjct: 400 LSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQK 459
Query: 226 VLKDEVAHHQTIPVQIGKEIEKITRKKVEMEKKKIVLE-------QEVKTLNDSLKKVEN 278
+ + E A + QI KE E + R EM+K+ +L+ +EV L LK ++
Sbjct: 460 LCRAEQAFQAS---QI-KENE-LRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQ 514
Query: 279 KVSAIVDEKENVIKEVEGKRALLEIKEREHNQLVKLLELARENEATSLTERGILDL---- 334
+++ +N +E++ K E R+ + + E + E L + DL
Sbjct: 515 ----CLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKL---AVADLEKQR 567
Query: 335 NLRNSLIDKQNYH-DELSRKQREKERDFRNLRKMELLLKVSWDALRQTQAL-------HQ 386
+ L+ K+ +H ++L+ K + E++ + L L K ++ L++ + L ++
Sbjct: 568 DCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENE 627
Query: 387 RLLLEMEA--------------------------------IPKDDSTLSERRRELH---- 410
+LL +ME+ + D LS R LH
Sbjct: 628 KLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLD 687
Query: 411 -KEVEVAKRNLAQQKIISEMESKLVEQQLAEENKLLKEQENMKELVVNLLRMTQIKIDEK 469
K VEV + LA ++ + E + Q EN LK + + V +L Q+ +E
Sbjct: 688 SKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQ-LTGQVEDLEHKLQLLSNEI 746
Query: 470 EQKSKDFLKAQQKYTNIVKEMKAKDLEIRIHKKKKCEIYRRLREFAKLYDTIRNERNKFV 529
K + + +Y ++ +K+KD + ++ + + +D + F
Sbjct: 747 MDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLL--------AFDQQPAMHHSFA 798
Query: 530 NLLHKAHQKVNEIKERHKMSLNELEILRNSAVSQERKLQNSMLKHANNVTIRESMQNDVR 589
N++ ++ + ER + L + +NSA+ LQN + ++ ++ M +D++
Sbjct: 799 NII---GEQGSMPSERSECRLEADQSPKNSAI-----LQNRVDSLEFSLESQKQMNSDLQ 850
Query: 590 KIVSKLQEMKEKKEAQLNNIDRLANTITMIEEEMVQLRKRYEKAVQHRN---ESGVQLIE 646
K +L ++K + E L +++ + + E ++ K E H+N E+ L
Sbjct: 851 KQCEELVQIKGEIEENLMKAEQMHQ--SFVAETSQRISKLQEDTSAHQNVVAETLSALEN 908
Query: 647 REEEICIFYEKI-----NIQEKMKLNGEIEIHLLEEKIQFLKMKIAEKQRQICVTQKLLP 701
+E+E+ + +K+ IQE K N HLLE+ ++ L++ +++ L
Sbjct: 909 KEKELQLLNDKVETEQAEIQELKKSN-----HLLEDSLKELQL----------LSETLSL 953
Query: 702 AKRSLDADLAVLQIQFSQCTDRIKDLEKQFVKPDGENRARFLPGKDLTEKEMIQKLDKLE 761
K+ + + +++ + + + T L++ + E + +IQK +
Sbjct: 954 EKKEMSSIISLNKREIEELTQENGTLKEINASLNQE------------KMNLIQKSESFA 1001
Query: 762 LQLAKKEEKLLEKDFIYEQVSRLTDRLCSKTQGCKQDTLLLAKKMNGYQRRIKNATEKMM 821
+ ++E+ + E Y+Q + + C +T +D L++K Q + + E ++
Sbjct: 1002 NYIDEREKSISELSDQYKQEKLILLQRCEETGNAYED---LSQKYKAAQEK-NSKLECLL 1057
Query: 822 ALVAELSMKQALTIELQKE--VREKEDFIFTCNSRIEKGLPLNKEIE 866
L + +E KE +E ++F+ E+ L E+E
Sbjct: 1058 NECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELE 1104
Score = 76.6 bits (187), Expect = 1e-13
Identities = 164/862 (19%), Positives = 360/862 (41%), Gaps = 121/862 (14%)
Query: 106 LQQADNFPEAFSTEVSKMREQLLKYQNEYNAVKEREFHN-QYRLNSLKEEKIIIVKEF-- 162
+++ ++ E + + K+ E++ +K +E + L+S ++E + K++
Sbjct: 1549 VEELESLCEVYRQSLEKLEEKM----ESQGIMKNKEIQELEQLLSSERQELDCLRKQYLS 1604
Query: 163 ------EKITKPG-EMEKKMKILRESTEELRKEIMQKKLEIKNLREDLASKQKQLLKEQK 215
+K+T EME K+ ++ TE+L E+ +L+++ L DL+S+ + +
Sbjct: 1605 ENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGL--DLSSRSLLGIDTED 1662
Query: 216 ELEELLGHQVVLKDEVAH--HQTIPVQIGKEIEKITRKKVEMEKKKIVLEQEVKTLNDSL 273
++ + K+ + +T + + +K ++ + ++ +KI VK +
Sbjct: 1663 AIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECS 1722
Query: 274 KKVENKVSAIVDEKENVIKEVEGKRALLEIKEREHNQLVKLLELARENEATSL----TER 329
+ + E K + E+ N LV + L + + +L E
Sbjct: 1723 GEQSPDTNY---EPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKET 1779
Query: 330 GILDLNLRNSLIDKQNYHDELSRKQREKERDFRNLRKMELLLKVSWDALRQTQALHQRLL 389
+L L + + D+ + L + +E + +L++++L+ K+
Sbjct: 1780 SNENLRLLHVIEDRDRKVESLLNEMKELDSKL-HLQEVQLMTKI-------------EAC 1825
Query: 390 LEMEAI----PKDDSTLSER-------RRELHKEVEVAKRNLAQQKIISEMESKL-VEQQ 437
+E+E I K++S LSE+ +EL + VE ++ + ++ ++ S+ +
Sbjct: 1826 IELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDN 1885
Query: 438 LAEENKLLKEQENMKELVVNLLRMTQIKIDEKEQKSKDFLKAQQKYTNIVKEMKAKDLEI 497
+A+ N KE+ E ++ +R + I+ + +L+A + K KD E
Sbjct: 1886 VAKVNDSWKERFLDVENELSRIRSEKASIEHEAL----YLEADLEVVQTEKLCLEKDNE- 1940
Query: 498 RIHKKKKCEIYRRLREFAKLYDTIRNERNKFVNLLHKAHQKVNEIKERHKMSLNELEILR 557
K ++ L E + + RN+ ++ + K ++++ E+ K ELE +
Sbjct: 1941 -----NKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQ 1995
Query: 558 NSAVSQERKLQNSMLKHANNVTIRESMQNDVRKIVSKLQEMKEKKEAQLNNIDRLANTIT 617
+ + +Q + + + +++ +DV +++ ++EK ++ + L+ T
Sbjct: 1996 SECL---HCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKC 2052
Query: 618 MIEEEMVQLRKRYEKAVQHRNESGVQLIEREEEICIFYEKINIQEKMKL----NGEI--- 670
+E ++ QL K E V+ +L E + YEK+N+ + ++ GE
Sbjct: 2053 ELENQIAQLNKEKELLVKESESLQARLSESD------YEKLNVSKALEAALVEKGEFALR 2106
Query: 671 ------EIHLLEEKIQFLKMKI-AEKQRQICVTQKLLPAKRSLDA-----DLAVLQIQFS 718
E+H L I+ L+++I A++++Q+ + +KL +R D+ + ++Q S
Sbjct: 2107 LSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMS 2166
Query: 719 QCTDRIKDL-------EKQFVKPDGENRARFLPGKDLTEKEMIQKLDKLELQLAKKEEKL 771
+ + L E + +K E AR L +L + + + L Q+ +K+ +L
Sbjct: 2167 EENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQL 2226
Query: 772 LEKDFIYEQVSRLTDRLCSKTQGCKQDTLLLAKKMNGYQRRIKNATEKMMALVAELSMKQ 831
E D + L + K+++ + + Q ++K E + AL + + +
Sbjct: 2227 SELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEML---QNQLKELNEAVAALCGDQEIMK 2283
Query: 832 ALTIELQKEVREKEDFIFTCNSRIEKGLPLNKEIEKEWLKV---LRDEEMHA-------- 880
A L + E+ + IEK + EK+ L V L++ E HA
Sbjct: 2284 ATEQSLDPPIEEEHQL----RNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVE 2339
Query: 881 -----LAIAEKSQEF--LEADN 895
L IA +QE LEA+N
Sbjct: 2340 NLERELEIARTNQEHAALEAEN 2361
Score = 58.2 bits (139), Expect = 4e-08
Identities = 149/756 (19%), Positives = 307/756 (40%), Gaps = 135/756 (17%)
Query: 168 PGEMEKKMKILRESTEELRKEIMQKKLEIKNLREDLASKQKQLLKEQKELE--------- 218
P +K++ L ++L+KE Q++ ++ +L + L K+++++E
Sbjct: 13 PTRALQKIQELEGQLDKLKKEKQQRQFQLDSL-------EAALQKQKQKVENEKTEGTNL 65
Query: 219 ------------------ELLGHQVVLKDEVAHHQTIPVQIG-KEIEK----ITRKKVEM 255
+ + H++ +K+ + Q + G K+IEK + R K E+
Sbjct: 66 KRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSEL 125
Query: 256 EKKKIVLEQEVKTLN--DSLKKVEN---------KVSAIVDEKENVIKEVEGKRAL-LEI 303
E+ + + +LN ++ +K+ S D KE KEVE ++ L E+
Sbjct: 126 ERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEV 185
Query: 304 KEREHNQLVKLLELARENEATSLTERGILDLNLRNSLI----DKQNYHDELSRKQREKER 359
K + + + L A ++ R I +S+ +K H + ++ R
Sbjct: 186 KALQAKKASQTLPQA------TMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRR 239
Query: 360 DF-RNLRKMELLLKVSWDALRQTQALHQRLLLEMEAIPKDDSTLSERRRELHKEV-EVAK 417
DF + E + S L+ + + + P L + +EL ++ E+
Sbjct: 240 DFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELEL 299
Query: 418 RNLAQQKIISEMESKLVEQQLAEENKLLKEQENMKELVVNLLRMTQIKIDEKEQKSKDFL 477
R +K + +K E QL E ++ E KE V+N R DE + + +
Sbjct: 300 RLQGHEKEMKGQVNKFQELQLQLEKAKVELIE--KEKVLNKCR------DELVRTTAQYD 351
Query: 478 KAQQKYTNIVKEMKAKDLEIRIHKKK----KCEIYRRLREFAKLY--DTIRNERN----- 526
+A KYT + +++K ++ ++ +C + ++++E K + + R +R+
Sbjct: 352 QASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLD 411
Query: 527 -KFVNLLHKAHQKVNEIKERHKMSLNELEILRNSAVSQERKLQNSMLKHANNVTIRESMQ 585
+ + + + Q++ + K H + EL+ L + E L+ K ++ Q
Sbjct: 412 QECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQ 471
Query: 586 NDVRKIVSKLQEMKEKKEAQLNNIDRLANTITMIEEEMVQLRKRYEKAVQHRNESGVQLI 645
++ ++EMK++ ++ ++ A + +E E+ +++ ++ E +
Sbjct: 472 IKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNT 531
Query: 646 EREEEICIFYEKINIQEKMKLNGEIEIHLLEEKIQFLKMKIAEKQRQICVTQKLLPAKRS 705
+E + EKIN QE L EK LK+ +A+ ++Q +Q LL +
Sbjct: 532 SQETMLRDLQEKINQQEN---------SLTLEK---LKLAVADLEKQRDCSQDLLKKRE- 578
Query: 706 LDADLAVLQIQFSQCTDRIKDLEKQFVKPDGENRARFLPGKDLTEKEMIQ-KLDKLELQL 764
I+ L + K + E++A L +L +KE + K +K
Sbjct: 579 ----------------HHIEQLNDKLSKTEKESKA-LLSALELKKKEYEELKEEKTLFSC 621
Query: 765 AKKE-EKLL-----EKDFIYEQVSRLTDRLCSKTQGCKQDTLLLAKKMNGYQRRIKNATE 818
K E EKLL EK+ + +++ L C KTQ K + + N R ++ E
Sbjct: 622 WKSENEKLLTQMESEKENLQSKINHL--ETCLKTQQIK------SHEYNERVRTLEMDRE 673
Query: 819 KMMALVAELSM---KQALTIELQK----EVREKEDF 847
+ + L +++ +E QK E+++K +F
Sbjct: 674 NLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEF 709
Score = 40.0 bits (92), Expect = 0.010
Identities = 43/162 (26%), Positives = 70/162 (43%), Gaps = 20/162 (12%)
Query: 79 MSTQESEVQLLQNAKRFTEQIQQQQFHLQQADNFPEAFSTEVSKMREQLLKYQNEYNAVK 138
+S+Q+ E+ LL+++K L + E+ K + LKY N+
Sbjct: 2739 LSSQKLEIDLLKSSKE----------ELNNSLKATTQILEELKKTKMDNLKYVNQLKKEN 2788
Query: 139 EREFHNQYRL----NSLKEEKIIIVKEFEKITKPGEMEKKMKILRESTEELRKEIMQKK- 193
ER L L+EEK I+ KE ++ E +K ++ +EL EI + K
Sbjct: 2789 ERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKE 2848
Query: 194 -LEIKNLRED-LASKQKQLLKEQKELEELLGHQVVLKDEVAH 233
LE K D K LL ++LE+ + +L+ +VAH
Sbjct: 2849 TLEEKTKEADEYLDKYCSLLISHEKLEKA---KEMLETQVAH 2887
Score = 37.7 bits (86), Expect = 0.052
Identities = 97/490 (19%), Positives = 194/490 (39%), Gaps = 58/490 (11%)
Query: 373 VSWDALRQTQALHQRLLLEMEAIPKDDSTLSERRRELHKEVEVAKRNLAQQKIISEMESK 432
+SW + L R L +++ + L + +++ +++ + L +QK
Sbjct: 1 MSWALEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQ------- 53
Query: 433 LVEQQLAEENKLLKEQENMKELVVNLLRMTQIKIDEKEQKSKDFLKAQQKYTNIVKEMKA 492
VE + E L +E + + E + L T+ KI + Q + + Q+ N K
Sbjct: 54 KVENEKTEGTNLKRENQRLME-ICESLEKTKQKISHELQVKESQVNFQEGQLNSGK---- 108
Query: 493 KDLEIRIHKKKKCEI-YRRLREFAKLYDTIRNERNKFVNLL--------HKAHQKVNEIK 543
K +E + K+C+ R ++ A+ D N N + + + K ++K
Sbjct: 109 KQIEKLEQELKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLK 168
Query: 544 ERHKMSLNELEILRNSAVSQERKLQNSMLKHANNVTIRESMQNDVRKIVSKLQEMKEKKE 603
E++ + E + L + + K + L A + R+ ++ V Q+ K
Sbjct: 169 EKYNKEVEERKRLEAEVKALQAKKASQTLPQA-TMNHRDIARHQASSSVFSWQQEKTPSH 227
Query: 604 AQLNN------IDRLANTITMIEE-----EMVQLRKRYEKAVQHRNESGVQLIER-EEEI 651
N+ D A+ + +E +Q+ KR + N S L+++ + +
Sbjct: 228 LSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQN 287
Query: 652 CIFYEKINIQEKMKLNGEIEIHLLEEKIQFLKMKIAEKQRQICVTQKLLPAKRSLDADLA 711
KIN E E E+ K Q L++++ + + ++ +K+L R +L
Sbjct: 288 QELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRD---ELV 344
Query: 712 VLQIQFSQCTDRIKDLEKQFVKPDGENRARFLPGKDLTEKEMIQKLDKLELQLAKKEEKL 771
Q+ Q + + LE++ K LTE Q+ E E+K+
Sbjct: 345 RTTAQYDQASTKYTALEQKL--------------KKLTEDLSCQR-QNAESARCSLEQKI 389
Query: 772 LEKDFIY-EQVSRLTDRLCSKTQGCKQDTLLLAKKMNGYQRRIKNATEKMMALVAEL-SM 829
EK+ + E++SR + Q C Q L +++ ++ KN + A + +L S+
Sbjct: 390 KEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQEL----QQAKNMHNVLQAELDKLTSV 445
Query: 830 KQALTIELQK 839
KQ L L++
Sbjct: 446 KQQLENNLEE 455
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 114 bits (285), Expect = 4e-25
Identities = 177/924 (19%), Positives = 383/924 (41%), Gaps = 151/924 (16%)
Query: 67 LKAKYTLLHDAVMSTQESEVQLLQNAKRFTEQIQQQQFHLQQADNFPEAFSTEVSKMREQ 126
LK + L S++ + QL + +++ LQ+ + + + + E
Sbjct: 251 LKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTEN 310
Query: 127 LLKYQNEYNAVKEREFHNQYRLNSLKEEKIIIVKEFE--------------------KIT 166
LLK + +Y ++E+ HN+ ++ + + K+ + +++
Sbjct: 311 LLKKEQDYTKLEEK--HNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELS 368
Query: 167 KPGEMEKKMKILRESTEELRKEIMQKKLEIKNLREDLASKQKQLLKEQKELEELLGHQVV 226
+ GE +K+K E E+ + K E K L++ K++ L+ Q E+ +L H +
Sbjct: 369 EKGEATQKLK---EELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQL--HSKL 423
Query: 227 LKDEVAHHQTIPVQIGKEIEKITRKKVEMEKKKIVLEQEVKTLNDSLKKVENKVSAIVDE 286
L+ E Q+G+ ++ ++ +K + EQ+V L L ++E ++
Sbjct: 424 LETER--------QLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQL------ 469
Query: 287 KENVIKEVEGKRALLEIKEREHNQ-------LVKLLELARENEATSLTERGILDLNLRNS 339
KE V E + L + K++ Q KL E + E L + G D ++N
Sbjct: 470 KEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQV-LRQIGDKDQKIQNL 528
Query: 340 LIDKQNYHDELSRKQREKERDFRNLRKMELLLKVSWDALRQTQALHQRLLLEMEAIPKDD 399
Q + +S ++E+E + ++ E V + L +++ E +
Sbjct: 529 EALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQS 588
Query: 400 STLSERRRELHKEVEVAKRNL--AQQKIIS------EMESKLVEQ--------------- 436
+ + + LH +V+ K +L AQ +++S E+ S+L E
Sbjct: 589 ESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKT 648
Query: 437 ------------QLAE--------ENKLLKEQENMKELVVNLLRMT-----------QIK 465
Q A+ +N L +Q+ + ++ L ++T Q++
Sbjct: 649 ELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLE 708
Query: 466 IDEKEQKSKDFLKAQQKYTNI---VKEMKAKDLEIRIHKKKKCEIYRRLREFAKLYDTIR 522
KE K K +L +QK + +K+++A LE++ K++ + ++ R+ +
Sbjct: 709 SHLKEYKEK-YLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRA 767
Query: 523 NERNKFVNL-----------LHKAHQKVNEIKERHKMSLNELEILRN--SAVSQERKLQN 569
E +K + + L K + + IK++ E +IL+ +SQE K+Q+
Sbjct: 768 TELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQH 827
Query: 570 SMLKHANNVTIRESMQNDVRKIVSKLQEMKEKKEAQLNNIDRLANTITMIEEEMVQLRKR 629
E + N ++ V++LQ++K +KEA + + + + ++ + + + +
Sbjct: 828 ------------EELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSE 875
Query: 630 YEKAVQHRNESGVQLIEREEEICIFYE---KINIQEKMKLNGEIEIHLLEEK--IQFLKM 684
+EK N+ G I E+ C + ++ ++ +K E++ L +EK LK+
Sbjct: 876 FEK----ENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKL 931
Query: 685 KIAEKQRQICVTQKLLPAKRSLDADLAVLQIQFSQCTDRIKDLEKQFVKPDGENRARFLP 744
++ Q Q+ Q L + + + LQ ++ + +KQ GE + L
Sbjct: 932 ELNSMQEQLIQAQNTL---KQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQ 988
Query: 745 GKDLTEKEMIQKLDKLELQLAKKEEKLLEKDFIYEQVSRLTDRLCSKTQGCKQDTLLLAK 804
+L E ++ Q+L + +LA ++EK+ YE+ +L S G + + L +
Sbjct: 989 KTEL-ENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQ 1047
Query: 805 KMNGYQRRIKNATEKMMALVAELSMKQALTIELQKEVREKEDFIFTCNSRIEKGLPLNKE 864
+ + ++ A E +++ ++ + L EL+ E ++++ ++
Sbjct: 1048 DLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQD 1107
Query: 865 IEKEWLKVLRDEEMHALAIAEKSQ 888
I+KE K L+++E+ + EKS+
Sbjct: 1108 IQKE--KSLKEKEL----VNEKSK 1125
Score = 109 bits (273), Expect = 1e-23
Identities = 171/810 (21%), Positives = 350/810 (43%), Gaps = 92/810 (11%)
Query: 84 SEVQLLQNAKRFTEQIQQQQFHLQQADNFPEAFSTEVSKMREQLLKYQNEYNAVKEREFH 143
+++Q + Q+Q++ LQ+ +V+++ E+L K Q+E + + H
Sbjct: 551 AKIQAGEGETAVLNQLQEKNHTLQE----------QVTQLTEKL-KNQSESHKQAQENLH 599
Query: 144 NQYRLNSLKEEKIIIVKEFEKITKPGEMEKKMKILRESTEELRKEIMQKKLEIKNLREDL 203
+Q ++E+K + +++ +E + L E ++++ Q ++IK E L
Sbjct: 600 DQ-----VQEQKAHLRAAQDRVLS---LETSVNELNSQLNESKEKVSQLDIQIKAKTELL 651
Query: 204 ASKQKQLLKEQKELEELLGH-QVVLKDEVAHHQTIPVQIGKEIEKITRKKV--------- 253
S + ++ +L+ L Q L+D+ I Q+ + K+ K+
Sbjct: 652 LSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHL 711
Query: 254 -EMEKKKIVLEQEVKTLNDSLKKVENKVSAIVDEKENVIKEVEGKRALLEIKEREHNQLV 312
E ++K + LEQ+ + L +KK+E + KE +++++ +R L E +L
Sbjct: 712 KEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELS 771
Query: 313 KLLELARENEATSLTERGILDLNLRNSLIDKQNYHDELSRKQREKE---RDFRNLRKMEL 369
K LE+ E E S T LDL ++ + ++ +L++++ EK+ +DF L +
Sbjct: 772 KQLEM--EKEIVSSTR---LDLQKKSEAL--ESIKQKLTKQEEEKQILKQDFETLSQETK 824
Query: 370 LLKVSWDALRQTQALH-QRLLLEMEAIPKDDSTLSER-----------RRELHKEVEVAK 417
+ + QT Q++ +E EA+ + ST+ ++ + E KE + K
Sbjct: 825 IQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGK 884
Query: 418 RNLAQ-QKIISEMESKL---VEQQLAEENKLLKEQENMKELVVNL---LRMTQIKIDEKE 470
+ +K E++ +L +E L E+ +L K E KE L L Q ++ + +
Sbjct: 885 AAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQ 944
Query: 471 QKSKDFLKAQQKYTNIVKEMKAKDLEIRIHKKKKCEIYRRLREFAKLYDTIRNERNKFVN 530
K K +Q+ + E+K + KKK+ E + + A L T NK
Sbjct: 945 NTLKQNEKEEQQLQGNINELKQSSEQ----KKKQIEALQGELKIAVLQKT--ELENKLQQ 998
Query: 531 LLHKAHQKVNEIKERHKMSLNELEILRNSAVSQE--RKLQNSMLKHANNVTIRESMQNDV 588
L +A Q++ KE+ + N E SQE ++LQ+ + + V
Sbjct: 999 QLTQAAQELAAEKEKISVLQNNYE------KSQETFKQLQSDFYGRESELLATRQDLKSV 1052
Query: 589 RKIVSKLQEMKEKKEAQLNNIDRLANTITMIEEEMVQLRKRYEKAVQHRNESGVQLIERE 648
+ +S QE Q+ N ++L + + + Q + E+ +Q R ++ +Q I++E
Sbjct: 1053 EEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKA-LQDIQKE 1111
Query: 649 EEIC---IFYEKINI---------QEK--MKLNGEIEIHLLEEKIQFLKMKIAEK---QR 691
+ + + EK + QEK KLN E++ H LE + +K A++ Q+
Sbjct: 1112 KSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQ 1171
Query: 692 QICVTQKLLPAKRSLDADLAVLQIQFSQCTDRIKDLEKQFVKPDGENRARFLPGKDLTEK 751
++ + K K +++ + QI Q ++L+K+F++ + + + + K++ K
Sbjct: 1172 KLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSE-IKEKEVGMK 1230
Query: 752 EMIQKLDKLELQLAKKEEKLLEKDFIYEQVSRLTDRLCSKTQGCKQDTLLLAKKMNGYQR 811
+ + KL +Q+ E L ++ R L +T + + +L + Q
Sbjct: 1231 KHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQD 1290
Query: 812 RIKNATEKMMALVAELSMKQALTIELQKEV 841
+ E+ + E+ Q +ELQ+++
Sbjct: 1291 ERRALLERCLKGEGEIEKLQTKVLELQRKL 1320
Score = 98.2 bits (243), Expect = 3e-20
Identities = 176/889 (19%), Positives = 383/889 (43%), Gaps = 116/889 (13%)
Query: 76 DAVMSTQESEVQLLQNAKRFTEQIQQQQFHLQQADNFPEAFSTEVSKMREQLLKYQNEYN 135
D +++ +E+Q L+ E+ Q + F+++Q + E + +++ + +E
Sbjct: 127 DGLVTDSSAELQSLEQQ---LEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEER 183
Query: 136 AVKEREFHNQYRLNSLKEEKIIIVKEF--EKITKPG---------EMEKKMKILRESTEE 184
+++E RL ++ ++++ E + +PG E+ + ++ T E
Sbjct: 184 SLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLE 243
Query: 185 LRKEIMQKKLEIKNLREDLASKQKQLLKEQKELEELLGHQVVLKDEVAHHQTIPVQIGKE 244
+E + K E K L+ AS + + + + EL + G Q EVA + ++
Sbjct: 244 RERESEKLKDECKKLQSQYASSEATISQLRSELAK--GPQ-----EVAVYVQELQKLKSS 296
Query: 245 IEKITRKKVEMEKKKIVLEQEVKTLNDSLKKVENKVSAIVDEKENVIKEVEGKRALLEIK 304
+ ++T+K + + + EQ+ L + K E VS K+N+ +A L K
Sbjct: 297 VNELTQKNQTLTENLLKKEQDYTKLEE--KHNEESVS-----KKNI-------QATLHQK 342
Query: 305 EREHNQLVKLL---ELARENEATSLTERGILDLNLRNSL--IDKQNYHDELSRKQREKER 359
+ + QL L E + L+E+G L+ L ++ + H + KQ +++R
Sbjct: 343 DLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQR 402
Query: 360 DFRNLRKMELLLKVSWDALRQTQALHQRLLLEMEAIPKDDSTLSERR-----RELHKEVE 414
+ + ++L +++ LH +LL + + L E+R + + KE +
Sbjct: 403 EEKEQHGLQLQSEIN--------QLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQ 454
Query: 415 VAKRNLAQQKIISEMESKL-----VEQQLAEENKLLKEQENMKELVVNLLRMTQIKIDEK 469
VA L ++ +++ K+ ++ QL + + +EQ+ +++ LR Q ++
Sbjct: 455 VADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQ---NDL 511
Query: 470 EQKSKDFLKAQQKYTNIVKEMKAKDLEIRIHKKKKCEIYRRLR----EFAKLYDTIRNER 525
EQ + QK N+ ++ I + +K++ ++Y +++ E A L + ++ +
Sbjct: 512 EQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVL-NQLQEKN 570
Query: 526 NKFVNLLHKAHQKVNEIKERHKMSLNELEILRNSAVSQERKLQNSMLKHANNVTIRESMQ 585
+ + + +K+ E HK + L + R Q+ +L S++
Sbjct: 571 HTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVL----------SLE 620
Query: 586 NDVRKIVSKLQEMKEKKEAQLNNIDRLANTITMIEEEMVQLRKRYEKAVQHRNESGVQLI 645
V ++ S+L E KE K +QL +I A T ++ E + +R + H + + L
Sbjct: 621 TSVNELNSQLNESKE-KVSQL-DIQIKAKTELLLSAEAAKTAQRAD-LQNHLDTAQNALQ 677
Query: 646 EREEEICIFYEKIN-----IQEKMKLNGEIEIHLLE--EKIQFLKMKIAEKQRQI-CVTQ 697
++++E+ +++ +Q+K + ++E HL E EK L+ K E + QI +
Sbjct: 678 DKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEA 737
Query: 698 KLLPAKRSLDADLAVLQIQFSQCTD---RIKDLEKQFVKPDGENRARFLPGKDLTEKEMI 754
L K S + L LQ Q TD R +L KQ E + L ++
Sbjct: 738 DSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQL-----EMEKEIVSSTRLDLQKKS 792
Query: 755 QKLDKLELQLAKKEE--KLLEKDF---------IYEQVSRLTDRLCSKTQGCKQDTLLLA 803
+ L+ ++ +L K+EE ++L++DF +E+++ ++ Q K + L
Sbjct: 793 EALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALM 852
Query: 804 KKMNGYQRRIKNATEKMMALVAELSMK----QALTIELQKEVRE-KEDFIFTCNSRIEKG 858
+++ + ++ ++ + +E + +A ++L+K +E K + +++
Sbjct: 853 TELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQ 912
Query: 859 LPLNKEIEKE-----WLKVLRDEEMHALAIAEKSQEFLEADNRQLPNGV 902
L K +EKE LK+ + L A+ + + E + +QL +
Sbjct: 913 KELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNI 961
Score = 88.6 bits (218), Expect = 3e-17
Identities = 119/539 (22%), Positives = 228/539 (42%), Gaps = 62/539 (11%)
Query: 70 KYTLLHDAVMSTQESEVQLLQNAKRFTEQIQQQQFHLQQADNFPEAFSTEVSKMREQLLK 129
K L D +QE+++Q + +IQ LQ+ EA TE+S ++++L K
Sbjct: 809 KQILKQDFETLSQETKIQ----HEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSK 864
Query: 130 YQNEY-NAVKEREFHNQYRLNSLKE-EKIIIVKEFEKITKPGEMEKKMKILRESTEELRK 187
+ N+ E E NQ ++ + EK + + + K+ K L++S E+ ++
Sbjct: 865 VSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKE 924
Query: 188 EIMQKKLEIKNLREDLASKQKQLLKEQKELEELLGHQVVLKDEVAHHQTIPVQIGKEIEK 247
Q KLE+ +++E L Q L + +KE ++L G+ LK + + E++
Sbjct: 925 ASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKI 984
Query: 248 ITRKKVEMEKKKIVLEQEVKTLNDSLKKVENKVSAIVDEKENVIKEVEGKRALLEIKERE 307
+K E+E K L+Q++ L + K+S + + E + K+ + RE
Sbjct: 985 AVLQKTELENK---LQQQLTQAAQELAAEKEKISVLQNNYEK--SQETFKQLQSDFYGRE 1039
Query: 308 HNQLVKLLELARENEATSLTERGILDLNLRNSLIDKQNYHDELSRKQREKERDFRNLRKM 367
L +L E SL + + ++ RN + ++ EL + E+D K
Sbjct: 1040 SELLATRQDLKSVEEKLSLAQEDL--ISNRNQIGNQNKLIQELKTAKATLEQD---SAKK 1094
Query: 368 ELLLKVSWDALRQTQALHQRLLLEMEAIPKDDSTLSERRRELHKEVEVAKRN--LAQQKI 425
E L+ AL+ Q ++ L E E + + + +E E+ K N L K+
Sbjct: 1095 EQQLQERCKALQDIQ--KEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKL 1152
Query: 426 --------ISEMESKLVEQQL-----AEENKLLKEQENMKELVVNLLRMTQIKIDEKEQK 472
+ + + L++Q+L A+ K EQE + ++ Q+K +E+E K
Sbjct: 1153 ESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILK----DQVKKEEEELK 1208
Query: 473 SKDFLKAQQKYTNIVKEMKAKDLEIRIHKKKKCEI---------------------YRRL 511
K+F++ + K + E+K K++ ++ H++ + ++ RR+
Sbjct: 1209 -KEFIEKEAK---LHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRV 1264
Query: 512 REFAKLYDTIRNERNKFVNLLHKAHQKVNEIKERHKMSLNELEILRNSAVSQERKLQNS 570
E K D +R E + + + ER E+E L+ + +RKL N+
Sbjct: 1265 SELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNT 1323
Score = 52.8 bits (125), Expect = 2e-06
Identities = 56/272 (20%), Positives = 128/272 (47%), Gaps = 26/272 (9%)
Query: 79 MSTQESEVQLLQNAKRFTEQIQ-QQQFHLQQADNFPEAFSTEVSKMREQLLKYQNEYNAV 137
+ Q +Q L+ AK EQ +++ LQ+ + E S ++L+ +++ +
Sbjct: 1070 IGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEI 1129
Query: 138 KEREFHNQYRLNSLKEE----KIIIVKEFEKITKPGEMEKKMKI-LRESTEELRKEIMQK 192
+E + + + L EE K+ +KE + ++ + K+ L+ + L+ + Q+
Sbjct: 1130 EEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQE 1189
Query: 193 KLEIKNLREDLASKQKQLLKEQKELE-----ELLGHQVVLKDEVAHHQTIPVQIG----- 242
K + L++ + ++++L KE E E E+ +V +K + + +QI
Sbjct: 1190 KRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNEN 1249
Query: 243 -----KEIEKITRKKVEMEKKKIVLEQEVKTLNDSLKKVENKVSAIVD---EKENVIKEV 294
KE + R+ E+EK+ L E+ L +++ +++ A+++ + E I+++
Sbjct: 1250 LGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKL 1309
Query: 295 EGKRALLEIKEREHNQLVKLLELARENEATSL 326
+ K +LE++ + N + EL REN++ +
Sbjct: 1310 QTK--VLELQRKLDNTTAAVQELGRENQSLQI 1339
Score = 48.1 bits (113), Expect = 4e-05
Identities = 59/282 (20%), Positives = 134/282 (47%), Gaps = 33/282 (11%)
Query: 8 TEKEEEEEKDEKDQEPIYAIVPTINIQDERFVDLSETPAFIFLHELHAMGKLPGTRMAAL 67
T +++ +K+++ QE A+ +IQ E+ + E ++E + ++ +
Sbjct: 1086 TLEQDSAKKEQQLQERCKALQ---DIQKEKSLKEKE-----LVNEKSKLAEIEEIKCRQE 1137
Query: 68 KAKYTLLHDAVMSTQESEVQLLQNAKRFTEQIQQQQFHLQ-QADNFPEAFSTEVSKMREQ 126
K + T L++ + S + ++ + N K + + QQ+ LQ +AD+ A E K +Q
Sbjct: 1138 K-EITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQE--KRNQQ 1194
Query: 127 LLKYQ--NEYNAVKEREFHNQYRLNSLKEEKIIIVKEFEK--------ITKPGE------ 170
+LK Q E +K+ + +L+S +EK + +K+ E+ IT E
Sbjct: 1195 ILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVK 1254
Query: 171 -----MEKKMKILRESTEELRKEIMQKKLEIKNLREDLASKQKQLLKEQKELEELLGHQV 225
++++ L + T++LR EI + ++N +++ + ++ LK + E+E+L +
Sbjct: 1255 KEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVL 1314
Query: 226 VLKDEVAHHQTIPVQIGKEIEKITRKKVEMEKKKIVLEQEVK 267
L+ ++ + ++G+E + + K + +K + EV+
Sbjct: 1315 ELQRKLDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQ 1356
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 113 bits (283), Expect = 7e-25
Identities = 173/804 (21%), Positives = 364/804 (45%), Gaps = 102/804 (12%)
Query: 67 LKAKYTLLHDAVMSTQESEVQLLQNAKRFTEQIQQQQFHLQQADNFPEAFSTEVSKMREQ 126
L+A TL + ST +Q Q +Q+++Q L+ E F+ ++S ++E+
Sbjct: 245 LQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEK 304
Query: 127 LLKYQNEYNAVKEREFHNQYRLNSLKEEKIIIVKEF-----EKITKPGEMEKKMKILRES 181
+ Y+ E + K+ E N+ + +EK I++E E+ K E++ K+ +
Sbjct: 305 IKVYEMEQD--KKVENSNKEEI----QEKETIIEELNTKIIEEEKKTLELKDKLTTADKL 358
Query: 182 TEELRKEIMQKKLEIKNLREDLASKQKQLLKEQKELEELLGHQVVLKDEVAHHQTIPVQI 241
EL+++I+QK EIKN++ +L + +++ + +E+++L+G L+ I
Sbjct: 359 LGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDI 418
Query: 242 GKEIEKITRKKVEMEKKKI-------VLEQEVKTLNDSLKKVENKVSAIVDEKENVIKEV 294
+ +E+ T++K+E + ++ +++ + + + + ++E + E EN ++
Sbjct: 419 VQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSY 478
Query: 295 EGKRALLEIKEREHNQLVKLLELARENEATSLTERGILDLNLRNSLIDKQNYHDELSRKQ 354
+ + E + +KL+ +A I +LN++ D S+K+
Sbjct: 479 SN----ITVNEDQ----IKLMNVA------------INELNIK--------LQDTNSQKE 510
Query: 355 REKERDFRNLRKMELLLKVSWDALRQTQALHQRLLLEMEAIPKDDSTLSERR---RELHK 411
+ KE ++ L+L+ RQ + L + L E I + T++E+ E HK
Sbjct: 511 KLKE-------ELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHK 563
Query: 412 EVEVAKRNLAQQKIISEMESKL--------------VEQQLAEENKLLKEQENMKELVVN 457
+ + A+ SE +L +E E+N +L +E +
Sbjct: 564 SLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELE 623
Query: 458 LLRMTQIKIDEKEQKSKDFLKAQQKYTNIVKEMKAKDLEIRIHKKKKCEIYRRLREFAKL 517
LR TQ+ +E+ SK LK + + + K KD + IH K++ + + E ++
Sbjct: 624 RLR-TQLLFSHEEELSK--LKEDLEIEHRINIEKLKD-NLGIHYKQQIDGLQ--NEMSQK 677
Query: 518 YDTIRNERNKFVNLLHKAHQKVNEIKERHKMSLNELEILRNSAVSQERKLQ-NSMLKHAN 576
+T++ E++ NL+ K +Q + EI + L +L+ ++ S+E LQ N + K
Sbjct: 678 IETMQFEKD---NLITKQNQLILEISK-----LKDLQQSLVNSKSEEMTLQINELQKEIE 729
Query: 577 NVTIRESMQNDVRKIVSKLQEMKEKKEAQLNNIDR-LANTITMIEEEMVQLRKRYEKAVQ 635
+ E + + + V +LQ E E Q+ + L +E E + K +K ++
Sbjct: 730 ILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAEN-SILKDEKKTLE 788
Query: 636 HRNESGVQLIEREEEICIFYEKINIQEKMKLNGEIEIHLLEEKIQFLKMKIAEKQRQICV 695
+ + +EE IF + I + K + E EI +L E+ + LK + + +I
Sbjct: 789 DMLK--IHTPVSQEERLIFLDSIKSKSKDSV-WEKEIEILIEENEDLKQQCIQLNEEIEK 845
Query: 696 TQKLLP-AKRSLDADLAVLQIQFSQCTDRIK-DLEKQFVKPDGENRARFLPGKDLTEKEM 753
+ A+++ + + LQ +++ C ++K DLE K + E +++ K L E+
Sbjct: 846 QRNTFSFAEKNFEVNYQELQEEYA-CLLKVKDDLEDSKNKQELEYKSKL---KALNEELH 901
Query: 754 IQKLDKLELQLAKK---EEKLLEKDFIY--EQVSRLTDRLCSKTQGCKQDTLLLAKKMNG 808
+Q+++ +++ E+K + + E V + T L K + K++ L L+++++
Sbjct: 902 LQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSD 961
Query: 809 YQRRIKNATEKMMALVAEL-SMKQ 831
++K ++ L E+ S+KQ
Sbjct: 962 LSEQLKQKHGEISFLNEEVKSLKQ 985
Score = 99.8 bits (247), Expect = 1e-20
Identities = 181/820 (22%), Positives = 359/820 (43%), Gaps = 129/820 (15%)
Query: 90 QNAKRFTEQIQQQQFHLQQADNFPEAFSTEVSKMR-----EQLLKYQNEYNAVKERE--- 141
Q A+ ++ + L + E + E+ +MR E L + Q A+K+R+
Sbjct: 148 QGAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGII 207
Query: 142 FHNQYRLNSLKEEKIIIVKEFEKITKPGEMEKKMKILRESTEELRKEIMQKKLEIKNLRE 201
L + EK ++EF ++T E +K++I ++L+ + +
Sbjct: 208 TQLTANLQQARREKDETMREFLELT---EQSQKLQI---QFQQLQASETLRNSTHSSTAA 261
Query: 202 DLASKQKQLLKEQKELEELLGHQVVLKDEVAHHQTIPVQIGKEIEKITRKKVEMEKKKIV 261
DL ++Q+L Q++LEE +L+D + +QI EKI K EME+
Sbjct: 262 DLLQAKQQILTHQQQLEE---QDHLLEDYQKKKEDFTMQISFLQEKI--KVYEMEQD--- 313
Query: 262 LEQEVKTLNDSLKKVENKVSAIVDEKENVIKE-----VEGKRALLEIKEREHNQLVKLLE 316
KKVEN + EKE +I+E +E ++ LE+K++ KLL
Sbjct: 314 ------------KKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDK-LTTADKLLG 360
Query: 317 LARENEATSLTERGILDLNLRNSLIDKQNYHDELSRKQREKERDFRNLR-KMELLLKVSW 375
+E E + L L NS +K+R+ + + L +E L K +
Sbjct: 361 ELQEQIVQKNQEIKNMKLELTNS-----------KQKERQSSEEIKQLMGTVEELQKRN- 408
Query: 376 DALRQTQALHQRLLLEMEAIPKDDSTLSERRRELHKEVEVAKRNLAQQKIISEMESKLVE 435
H+ E + + + + + +L E++ + Q+I+ +M+ +L+
Sbjct: 409 ---------HKDSQFETDIVQRMEQETQRKLEQLRAELD----EMYGQQIV-QMKQELIR 454
Query: 436 QQLAEENKLLKEQENMKELVVNLLR-MTQIKIDEKEQKSKDF----LKAQQKYTNIVKEM 490
Q +A+ ++ + E N LR + I ++E + K + L + + TN KE
Sbjct: 455 QHMAQMEEMKTRHKGEME---NALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKE- 510
Query: 491 KAKDLEIRIHKKKKCEIYRRLREFAKLYDTIRNERNKFVNLLHKAHQKVNEIKERHKMSL 550
K K+ E+ + ++KC + R+L + + R + + + + K+N E HK SL
Sbjct: 511 KLKE-ELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLN---EAHK-SL 565
Query: 551 NELEILRNSAVSQERKLQNSMLKHANNVT---IRESMQNDVRKIVSKLQEMKEKKEAQLN 607
+ +E L+ VS + LKH VT I+ M + V L M E +EA+L
Sbjct: 566 STVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAV--LDRMAESQEAELE 623
Query: 608 NIDRLANTITMIEEEMVQLRKRYEKAVQHRNESGVQLIEREEEICIFYEKINIQEKMKLN 667
+ + EEE+ +L++ E ++HR + + + ++ + I Y K +++
Sbjct: 624 RL--RTQLLFSHEEELSKLKEDLE--IEHR----INIEKLKDNLGIHY-------KQQID 668
Query: 668 G-EIEIHLLEEKIQFLKMKIAEKQRQICVTQKLLPAKRSLDADLAVLQIQFSQCTDRIKD 726
G + E+ E +QF K + KQ Q+ +L + D +++ + + T +I +
Sbjct: 669 GLQNEMSQKIETMQFEKDNLITKQNQL-----ILEISKLKDLQQSLVNSKSEEMTLQINE 723
Query: 727 LEKQFVKPDGENRARFLPGKDLTEKEMIQKLDKLELQLAKKEEKLLEK--------DFIY 778
L+K+ E + + +++ E ++ K + LE Q+ +KE L EK +
Sbjct: 724 LQKEIEILRQEEKEKGTLEQEVQELQL--KTELLEKQMKEKENDLQEKFAQLEAENSILK 781
Query: 779 EQVSRLTDRLCSKTQGCKQDTLLLAKKMNGYQRRIKNAT--EKMMALVAELSMKQALTIE 836
++ L D L T +++ L+ ++ + + K++ +++ L+ E + I+
Sbjct: 782 DEKKTLEDMLKIHTPVSQEERLIF---LDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQ 838
Query: 837 LQKEV-REKEDFIFTCNSRIEKGLPLN-KEIEKEWLKVLR 874
L +E+ +++ F F EK +N +E+++E+ +L+
Sbjct: 839 LNEEIEKQRNTFSFA-----EKNFEVNYQELQEEYACLLK 873
Score = 98.6 bits (244), Expect = 2e-20
Identities = 180/911 (19%), Positives = 390/911 (42%), Gaps = 135/911 (14%)
Query: 79 MSTQESEVQLLQNAKRFTEQIQQQQFHLQQADNFPEAFSTEVSKMREQLLKYQNEYNAVK 138
+ QE + L R EQ+ + L +A+ + ++ E + Q+ + + + ++
Sbjct: 1893 LKCQEELRERLHEESRAREQLAVE---LSKAEGVIDGYADEKTLFERQIQEKTDIIDRLE 1949
Query: 139 EREFHNQYRLNSLKEEKIIIVKEFEKITKPGEMEK------KMKILRESTEELRKEIMQK 192
+ RL L+ E+ I +E E +++ E K + ++L+E TE+L KE ++
Sbjct: 1950 QELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQE-TEKLMKEKLEV 2008
Query: 193 KLEIKNLREDLASKQKQLLKEQKELEELLGHQVVLKDEV--------AHHQTIPVQIGKE 244
+ + + +R+DL QKQ+ + ++EE + + L+ E +Q + Q+ K
Sbjct: 2009 QCQAEKVRDDL---QKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKM 2065
Query: 245 IEKITRKKVEMEKKKIVLEQEVKTLNDSLKKV------ENKVSAIVDEKENVIKEVEGKR 298
+ + + ++ E ++ V +QE++ L LK V + V++ N +KE K
Sbjct: 2066 RKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKC 2125
Query: 299 ALLEIKEREHNQLVKLLELARENEATSLTERGILDLNLRNSLIDKQNYHDELSRKQREKE 358
+ L + + + + ++ NE E + +L +L+ + ++ ++
Sbjct: 2126 SELLLSKEQLQR-----DIQERNEEIEKLEFRVRELE--QALLVSADTFQKVEDRKHFGA 2178
Query: 359 RDFRNLRKMELLLKVSWDALRQTQALHQRLLLEMEAIPKDDSTLSERRRELHKEVEVAKR 418
+ + +E+ L+ DA+ + + L ++E ++ +E ++LH ++E+ K+
Sbjct: 2179 VEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKK 2238
Query: 419 NLAQQKIISEMESKLVEQQLAEENKLLKEQENMKE--------LVVNLLRMTQIKIDE-K 469
+ E E+KL + + + +KE + M +++ +++ID+
Sbjct: 2239 ESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLN 2298
Query: 470 EQKSKDFLKAQQKYTNIVKEMKAK-----DLEIRIH---KKKKCEIYRRLREFAKLYDTI 521
EQ +K L+ Q K T K ++ K DLE +I ++C R E +L + I
Sbjct: 2299 EQVTK--LQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVI 2356
Query: 522 RNERNKFVNLLHKAHQKVNEIKERHKMSLNELEIL---------RNSAVSQERKLQNSML 572
+ + N+ K + + E ++L+++ + ++E ++L
Sbjct: 2357 EKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVL 2416
Query: 573 KHAN---NVTIRE--SMQNDVRKIVSKLQEMKEKK-EAQLNNI--DRLANTITMIEEEMV 624
K N N +E S++ + R+ V K+Q + E ++++ D+ + + E+ +
Sbjct: 2417 KETNFKMNQLTQELFSLKRE-RESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALK 2475
Query: 625 QLRKR-YEKAVQHRNESGVQLIE------------REEEICIFYEKINIQEKMKLNGEIE 671
L + Y K+ + + + +E ++ E+ Y++I + M+ G+ E
Sbjct: 2476 SLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQI---KDMQEQGQFE 2532
Query: 672 IHLLEEKIQFLKMKIAEKQRQICVTQKLLPA----------KRSLDADLAVLQIQ----- 716
+L++KI L+ + EK V+Q L A +++ ++ IQ
Sbjct: 2533 TEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQL 2592
Query: 717 --------FSQCTDRIKDLEKQFVKPDGENRARFLPGKDLTEKEMIQKLDKLELQLAKKE 768
S T RI +LE Q V+ + + EKE ++ +K + +KE
Sbjct: 2593 REDELGSDISALTLRISELESQVVE---------MHTSLILEKEQVEIAEK---NVLEKE 2640
Query: 769 EKLLEKDFIYE-----QVSRLTDRLCSKTQGCKQDT-LLLAKKMNGYQRRIKNATEKMMA 822
+KLLE + E Q + R + K T L + + +G+ ++ + +A
Sbjct: 2641 KKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVA 2700
Query: 823 LVAELSMKQALTIELQKEVREKEDFIFTCNSRIEKGLPLNKE---IEKEWLKVLRDEEMH 879
AEL+ + +LQ+E+ KE T + ++K L ++ KE L +L E+
Sbjct: 2701 TKAELASYKEKAEKLQEELLVKE----TNMTSLQKDLSQVRDHLAEAKEKLSILEKEDET 2756
Query: 880 ALAIAEKSQEF 890
+ ++K+ F
Sbjct: 2757 EVQESKKACMF 2767
Score = 81.6 bits (200), Expect = 3e-15
Identities = 140/762 (18%), Positives = 318/762 (41%), Gaps = 135/762 (17%)
Query: 83 ESEVQLLQNAKRFTEQIQQQQFHLQ-QADNFPEAFSTEVSKMREQLLKYQNEYNAVKERE 141
+ E+++L+ ++ ++Q+ LQ + + + + + ++E+ + + E + +K+ +
Sbjct: 725 QKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEK 784
Query: 142 --FHNQYRLNS--LKEEKIIIVKEFEKITKPGEMEKKMKILRESTEELRKEIMQKKLEIK 197
+ ++++ +EE++I + + +K EK+++IL E E+L+++ +Q EI+
Sbjct: 785 KTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIE 844
Query: 198 NLREDLASKQKQLLKEQKELEELLGHQVVLKDEVAHHQTIPVQIGKEIEKITRKKVEMEK 257
R + +K +EL+E + +KD++ + ++++E +
Sbjct: 845 KQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKN-------------KQELEYKS 891
Query: 258 KKIVLEQEVKTLNDSLKKVENKVSAIVDEKENVIKEVEGKRALLEIKEREHNQLVKLLEL 317
K L +E+ + V+ K S ++K V + +E + E+ E++ +L++ LE+
Sbjct: 892 KLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLE----MGEVVEKDTTELMEKLEV 947
Query: 318 ARENEATSLTERGILDLNLRNSLIDKQ--NYHDELSR-----KQREKERDFRNLRKMELL 370
T+R L+L+ R S + +Q H E+S K ++E++ +LR EL
Sbjct: 948 ---------TKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELE 998
Query: 371 LKVSWDALRQTQALHQRLLLEMEAIPKDDSTLSERRRELHKEVEVAKRNLAQQKIISEME 430
+ ++ + Q+ ++ ++ + T++ R E V+K N K E
Sbjct: 999 IIINHNRAENVQSCDTQVSSLLDGVV----TMTSRGAE----GSVSKVN----KSFGEES 1046
Query: 431 SKLVEQQLAEENKLLKEQENMKELVVN---------LLRMTQIKIDEKEQKSKDFLKAQQ 481
+VE +++ EN + E+ ++L+++ LR TQ ++K QK + LK++Q
Sbjct: 1047 KIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQ 1106
Query: 482 KYTNIVKEMKAKDLEIRIHKKKKCEIYRRLREFAKLYDTIRNERNKFV-----NLLHKAH 536
DL +++ ++ C ++ + + NE++K + L+
Sbjct: 1107 N-----------DLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQE 1155
Query: 537 QKVNEIKERHKMSLNELEILRNSAVSQERKLQNSMLKHANNVTIRESMQNDVRKIVSKLQ 596
+K+ E+++ H++ EL+ ++ E K + ++ KLQ
Sbjct: 1156 EKIKELQKIHQL---ELQTMKTQETGDEGK--------------------PLHLLIGKLQ 1192
Query: 597 EMKEKKEAQLNNIDRLANTITMIEEEMVQLRKRYEKAVQHRNESGVQLIEREEEICIFYE 656
+ A T+ + E + E + + SG + E E+ Y
Sbjct: 1193 K------AVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYR 1246
Query: 657 KINIQEKMKLNGEIEIHLLEEKIQFLKMKIAEKQRQICVTQKLLPAKRSLDADLAVLQIQ 716
E+ +E + L K+ E+ ++ V Q L D ++++
Sbjct: 1247 -------------YEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTD--GMKLE 1291
Query: 717 FSQCTDRIKDLEKQFVKPDGENRARFLPGKDLTEKEMIQKLDKLELQLAKKEEKLLEKDF 776
F + + + E +F+ ++ L D+ K + L LE K
Sbjct: 1292 FGE--ENLPKEETEFLSI--HSQMTNLEDIDVNHKSKLSSLQDLE------------KTK 1335
Query: 777 IYEQVSRLTDRLCSKTQGCKQDTLLLAKKMNGYQRRIKNATE 818
+ EQV L + S Q K+ +++ Q+R++ +E
Sbjct: 1336 LEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSE 1377
Score = 80.1 bits (196), Expect = 9e-15
Identities = 186/891 (20%), Positives = 377/891 (42%), Gaps = 155/891 (17%)
Query: 7 DTEKEEEEEKDEKDQEPIYAIVPTINIQDER-FVDLSE--TPAFIFLHELHAMGKLPGTR 63
D + E +++ +++E I + T I++E+ ++L + T A L EL
Sbjct: 313 DKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQE 372
Query: 64 MAALKAKYTLLHDAVMSTQESEVQLLQNAKRFTEQIQQQQFHLQQADNFPEAFSTEVSKM 123
+ +K + T ++++ E Q + K+ +++ LQ+ ++ F T++ +
Sbjct: 373 IKNMKLELT-------NSKQKERQSSEEIKQLMGTVEE----LQKRNHKDSQFETDIVQR 421
Query: 124 REQLLKYQNEYNAVKEREFHNQYRLNSLKEEKI---IIVKEFEKITKPGEMEK------- 173
EQ + + E + E + Q ++ +K+E I + E K GEME
Sbjct: 422 MEQETQRKLEQLRAELDEMYGQ-QIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSN 480
Query: 174 ------KMKILRESTEELRKEIMQKKLEIKNLREDLASKQKQLLKEQKELEELLGHQVVL 227
++K++ + EL ++ + + L+E+L ++ Q++LE+L+
Sbjct: 481 ITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFS 540
Query: 228 KDEVAH-HQTIPVQIGK----------------EIEKITRKKVEMEKKKIVLEQEVKTLN 270
++++ QTI Q K EI + + E+E K E EV
Sbjct: 541 REQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKH---EAEVTNYK 597
Query: 271 DSLKKVENKVSAIVDEK-ENVIKEVEGKRA-LLEIKEREHNQLVKLLELARENEATSLTE 328
L+ +E + +A++D E+ E+E R LL E E ++L + LE+ L +
Sbjct: 598 IKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKD 657
Query: 329 RGILDLNLRNSLIDKQNYHDELSRKQREKERDFRNL--RKMELLLKVS-WDALRQT--QA 383
L ++ + + QN E+S+K + + NL ++ +L+L++S L+Q+ +
Sbjct: 658 N--LGIHYKQQIDGLQN---EMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNS 712
Query: 384 LHQRLLLEMEAIPKDDSTLSERRRE---LHKEV-EVAKRNLAQQKIISEMESKLVEQ--Q 437
+ + L++ + K+ L + +E L +EV E+ + +K + E E+ L E+ Q
Sbjct: 713 KSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQ 772
Query: 438 LAEENKLLKEQENMKELVVNLLRMTQ-----IKIDEKEQKSKDFLKAQQKYTNIVKEMKA 492
L EN +LK+++ E ++ + I +D + KSKD + ++ I +
Sbjct: 773 LEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDL 832
Query: 493 KDLEIRIHKK------------KKCEI-YRRLRE----FAKLYDTIRNERNKFVNLLHKA 535
K I+++++ K E+ Y+ L+E K+ D + + +NK L +K+
Sbjct: 833 KQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNK-QELEYKS 891
Query: 536 HQK-VNEIKERHKMSLNELEILRNSAVSQERKL--------------QNSMLKHANNVTI 580
K +NE E H +N + S+V E K + L VT
Sbjct: 892 KLKALNE--ELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTK 949
Query: 581 RESMQNDVRKIVSKLQEMKEKKEAQLNNIDRLANTITMIEEEMVQLRKR-YEKAVQHRNE 639
RE ++ R +S L E ++K +++ ++ ++ E+E V LR R E + H
Sbjct: 950 REKLELSQR--LSDLSEQLKQKHGEISFLNEEVKSLKQ-EKEQVSLRCRELEIIINHNRA 1006
Query: 640 SGVQ--------LIEREEEICIFYEKINIQEKMKLNGEIEIHLLEEKIQFLKMKIAEKQR 691
VQ L++ + + ++ + K GE ++E+K+ F M + E+ +
Sbjct: 1007 ENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESK 1066
Query: 692 QICVTQKLLPA--------------------------------KRSLDADLAVLQIQFSQ 719
Q + LP+ + ++A L + +S
Sbjct: 1067 QEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYST 1126
Query: 720 CTDRIKD-LEKQFVKPDGENRARFLPGKDLTEKEMIQKLDKLELQLAKKEE 769
D++++ +E + K + + ++ KE +QK+ +LELQ K +E
Sbjct: 1127 HVDQVREYMENEKDKALCSLKEELIFAQEEKIKE-LQKIHQLELQTMKTQE 1176
Score = 75.5 bits (184), Expect = 2e-13
Identities = 168/841 (19%), Positives = 335/841 (39%), Gaps = 146/841 (17%)
Query: 183 EELRKEIMQKKLEIKNLREDLASKQKQL-LKEQKELEELLGHQVVLKDEVAHHQTIPVQI 241
EE +K++ K ++ R+ A Q K+QK+ + K +V+ H + +
Sbjct: 4 EERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSS----KHDVSAHHDLNIDQ 59
Query: 242 GKEIEKITRKKVEMEKKKIVLEQEVKTLNDS---------LKKVENKVSAIVDEKENVIK 292
+ E +E I ++TL+ ++E+++S D+ +
Sbjct: 60 SQCNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSS--- 116
Query: 293 EVEGKRALLEIKEREHNQLVKLLELARENEA---TSLTERGILDLN-----LRNSLIDKQ 344
EV G ++ K L RE E S +E+G D + + L KQ
Sbjct: 117 EVNGCSFVMRTG--------KPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQ 168
Query: 345 NYHDELSRKQREKERDF-----RNLRKMELLLKVSWDALRQTQALHQRLLLEMEAIPKDD 399
+ +EL+R+ E + + L++ E +K + Q A Q+ E + ++
Sbjct: 169 HEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREF 228
Query: 400 STLSERRRELHKEVEVAKRN----------LAQQKIISEMESKLVEQQLAEENKLLKEQE 449
L+E+ ++L + + + + A + ++ + +QQL E++ LL++ +
Sbjct: 229 LELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQ 288
Query: 450 NMKELVVNLLRMTQ--IKIDEKEQKSK----DFLKAQQKYTNIVKEMKAKDLEIRIHKKK 503
KE + Q IK+ E EQ K + + Q+K T I++E+ K +E +KK
Sbjct: 289 KKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKET-IIEELNTKIIE---EEKK 344
Query: 504 KCEIYRRLREFAKLY-----------DTIRNERNKFVNLLHKAHQKVNEIKE-------- 544
E+ +L KL I+N + + N K Q EIK+
Sbjct: 345 TLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEEL 404
Query: 545 ---RHKMSLNELEILRNSAVSQERKLQN--SMLKHANNVTIRESMQNDVRKIVSKLQEMK 599
HK S E +I++ +RKL+ + L I + Q +R+ +++++EMK
Sbjct: 405 QKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMK 464
Query: 600 EKKEAQLNNIDRLANTITMIEEEMVQLRKRYEKAVQHRNESGVQLIEREEEI-CIFYEKI 658
+ + ++ N R + IT+ E+++ + + ++ Q + +EE+ I EK
Sbjct: 465 TRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKC 524
Query: 659 NIQEKMKLNGEIEIHLLEEKIQFLKMKIAEKQRQICVTQKLLPAKRSLDAD--------- 709
+Q +++ E E+ E+IQ + IAE++ ++ K L L A+
Sbjct: 525 ALQRQLEDLVE-ELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRK 583
Query: 710 ----------------LAVLQIQFSQCTDRIKD--------LEKQFVKPDGENRARFLPG 745
L +L+ + + DR+ + L Q + E ++
Sbjct: 584 ELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKED 643
Query: 746 KDLTEKEMIQKL--------------------DKLELQLAKKEEKLLEKDFIYEQVSRLT 785
++ + I+KL K+E +K+ + +++ + ++S+L
Sbjct: 644 LEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLK 703
Query: 786 DRLCSKTQGCKQDTLLLAKKMNGYQRRIKNATEKMMALVAELSMKQALTIELQKEVREKE 845
D S ++ L ++ ++ ++ L E+ Q T L+K+++EKE
Sbjct: 704 DLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKE 763
Query: 846 DFIFTCNSRIEKGLPLNKE--IEKEWLKVLRDE-EMHALAIAEKSQEFLEADNRQLPNGV 902
N EK L E I K+ K L D ++H E+ FL++ + + V
Sbjct: 764 ------NDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSV 817
Query: 903 Y 903
+
Sbjct: 818 W 818
Score = 70.5 bits (171), Expect = 7e-12
Identities = 183/926 (19%), Positives = 391/926 (42%), Gaps = 115/926 (12%)
Query: 80 STQESEVQLLQNAKRFTE-QIQQQQFHLQQADNFPEAFSTEVSKM--------REQLLKY 130
S++++ Q F E ++ Q Q Q + F E + +E LL
Sbjct: 1473 SSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSN 1532
Query: 131 QNEYNAVKEREFHNQYRLNSLKEEKIIIVKEF---EKITKPGEMEKKMKILRESTEELRK 187
+ ++ + ++ ++K IV++ E + +++ + E E++R+
Sbjct: 1533 SDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQ 1592
Query: 188 EIMQKKLEIKNLREDLASKQKQLLKEQKELEELLGHQVV-LKDEVAHHQTIPVQ-IGKEI 245
E++++ E + E L + ++ Q+E +E L ++ L ++A +I + + E
Sbjct: 1593 ELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSER 1652
Query: 246 EKITRKKVEMEKKKIVLEQE--VKTLNDSLKKVENKVSAIVDEKENVIKEVEGKRALLEI 303
E++ +++E K+ + +E L +S + +N + +E KE E R ++
Sbjct: 1653 ERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDV 1712
Query: 304 K-----------EREHNQLVK-LLELARENEATSLT----ERGILDLNLRN----SLI-- 341
++ +N+L+K LLE+ + A T GILD + ++ SLI
Sbjct: 1713 PPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWR 1772
Query: 342 ------DKQNYHDELSRKQREKERDFRNLRKMELLLKVSWDALRQTQALHQRLLLEMEAI 395
K H+E +R E + + + + L QRL+ A
Sbjct: 1773 SEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAG 1832
Query: 396 PKDDSTLSERRRELHKEVEVAKRNLAQQKIISEMESKLVEQQLAEENKLLKEQENMKELV 455
+ D E + ++ A L + ISE S+L E + +L++E K+
Sbjct: 1833 TEIDPENEELMLNISSRLQAAVEKLLE--AISETSSQL-EHAKVTQTELMRESFRQKQEA 1889
Query: 456 VNLLRMTQIKIDEKEQKSKDFLKAQQKYTNIVKEMKAKDLEIRIHKKKKCEIYRRLREFA 515
L+ +E ++ + +A+++ + E+ + I + +K R+++E
Sbjct: 1890 TESLKCQ----EELRERLHEESRAREQ---LAVELSKAEGVIDGYADEKTLFERQIQEKT 1942
Query: 516 KLYDTIRNERNKFVNLLHKAHQKVNEIKERHKMSLNELEILRNSAVSQERKL---QNSML 572
+ D + E N L + + +I+E ++ + E ++ A E++L ++
Sbjct: 1943 DIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLM 2002
Query: 573 KHANNVTIR-ESMQNDVRKIVSKLQEMKEKKEAQLNNIDRLANTITM-IEEEMVQLRKRY 630
K V + E +++D++K V L+ E++ ++ +++ NT M + ++ L K+
Sbjct: 2003 KEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQL 2062
Query: 631 EKAVQHRNESGVQLIEREEEICIFYEKI-NIQEKMKL-----------NGEIE---IHLL 675
EK + +E Q I+RE E +F ++I +++++K+ E+E HL
Sbjct: 2063 EKMRKFLDE---QAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLK 2119
Query: 676 EEKIQFLKMKIAEKQRQICV------TQKLLPAKRSLDADLAVLQIQFSQCTDRIKDLEK 729
E+ + ++ ++++Q Q + +KL R L+ L V F + DR K
Sbjct: 2120 EKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDR-KHFGA 2178
Query: 730 QFVKPDGENRARFLPGKDLTEKEMIQKLDKLELQLAKKEEKLLEKDFIYEQVSRLTDRL- 788
KP+ + +D +++ +++ LE QL + E+L K+ E+V +L +L
Sbjct: 2179 VEAKPELSLEVQLQAERDAIDRKE-KEITNLEEQLEQFREELENKN---EEVQQLHMQLE 2234
Query: 789 ------CSKTQGCKQDTLLLAKKMNGYQRRIKN----ATEKMMALVAELSM----KQALT 834
++ Q +Q+ L M IK +T+ L + + K+
Sbjct: 2235 IQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEI 2294
Query: 835 IELQKEVR--EKEDFIFTCNSRIEKGLPLNKEIE---------KEWLKVLRDEEMHAL-A 882
+L ++V +++ I T N IE+ L +++E +E +K R+EE+ L
Sbjct: 2295 DQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNE 2354
Query: 883 IAEKSQEFLEADNRQLPNGVYTTAEQ 908
+ EK Q+ L ++ ++ +E+
Sbjct: 2355 VIEKLQQELANIGQKTSMNAHSLSEE 2380
Score = 64.7 bits (156), Expect = 4e-10
Identities = 162/901 (17%), Positives = 371/901 (41%), Gaps = 168/901 (18%)
Query: 62 TRMAALKAKYTLLHDAVMSTQESEVQLLQNAKRF-TEQIQQQQFHLQQADNFPEAFSTEV 120
TR+ L++ + D ++ +++ +Q +F TE +Q++ +LQ+ A +
Sbjct: 2499 TRLLQLESTVSA-KDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVS 2557
Query: 121 SKMREQLLKY----QNEYNAVKEREFHNQYRLNSLKEEKI------IIVKEFEKITKPGE 170
E + +Y Q+ E E N LN L+E+++ + ++ E ++ E
Sbjct: 2558 QIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVE 2617
Query: 171 MEKKMKILRESTEELRKEIMQKK---LEIKNLREDLASKQKQLLKEQK------------ 215
M + + +E E K +++K+ LE++ L E KQ++ K++
Sbjct: 2618 MHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTE 2677
Query: 216 ------------ELEELLGHQVVLKDEVAHHQTIPVQIGKEIEKITRKKVEMEKKKIVLE 263
ELE L V K E+A ++ ++ EK+ + + E L+
Sbjct: 2678 LFHSNEESGFFNELEALRAESVATKAELASYK-------EKAEKLQEELLVKETNMTSLQ 2730
Query: 264 QEVKTLNDSLKKVENKVSAIVDEKENVIKEVEGKRALL------EIKEREHNQLVKLLEL 317
+++ + D L + + K+S + EKE+ + E K+A + ++ + +Q L++
Sbjct: 2731 KDLSQVRDHLAEAKEKLSIL--EKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKI 2788
Query: 318 ARENEATS-LTERGILDLNLRNSLIDKQNYHDELSRKQREKERDFRNLRKMELLLKVSWD 376
+ N+ L + + +NL++ ++ E+ + EK + L E+L S
Sbjct: 2789 SSSNQTPQILVKNAGIQINLQSECSSEEV--TEIISQFTEKIEKMQELHAAEILDMESRH 2846
Query: 377 ALRQTQALHQRLLLEMEAIPKDDSTLSE-----RRRELHKEVEVAKRNLAQQKIISEMES 431
+ +T+ L + + ++ + ++ TL R +E E+A + Q + I +S
Sbjct: 2847 -ISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDS 2905
Query: 432 ----------------KLVEQQLAEENKLLKEQ--ENMKELV-------VNLLRMTQIKI 466
+ + EE++ + + +K L+ + +L +T+
Sbjct: 2906 GSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPY 2965
Query: 467 DEKE-----QKSKDFLKAQQKYTNIVKEMKAKDLEIRIHKKKKCEIYRRLREFAKLYDTI 521
+ E Q S+ +L+ ++ Y N + +K DL ++ +++ E+Y
Sbjct: 2966 SDGEDHSIQQVSEPWLEERKAYINTISSLK--DLITKMQLQREAEVYDS----------- 3012
Query: 522 RNERNKFVNLLHKAHQKVNEIKERHKMSLNELEILRNSAVSQERKLQNSMLKHANNVTIR 581
++H+ ++ + ++L ++ + S + + + + L + V +
Sbjct: 3013 -----------SQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLL 3061
Query: 582 ESMQNDVRKIVSKLQEMKEKKEAQLNNIDRLANTITMIEEEMVQLRKRYEKAVQHRNESG 641
++ ++QE + +A + + + + E + + + K R +
Sbjct: 3062 NCLEQ-------RIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQES 3114
Query: 642 VQLIEREEEICIFYEKINIQEKMKLNGEIEIHL---------LEEKIQFLKMKIAEKQRQ 692
E+ + + Y NIQ+K E+++ L L+E++ KM +AE + +
Sbjct: 3115 ----EKPSQELLEY---NIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSE 3167
Query: 693 ICVT----QKLLPAKRSLDADLAVLQIQFSQCTDRIKDLEKQFVKPDGENRARFLPGKDL 748
+ T + L A+ +L +++ TD + L ++R
Sbjct: 3168 LAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSR--------- 3218
Query: 749 TEKEMIQKLDKLELQLAKKEEKLLEKDFIYEQVSRLTDRLCSKTQGCKQDTLLLAKK--- 805
E+ L+K + +L + EE+ +K E++ L L S+ Q Q LLL ++
Sbjct: 3219 ---ELQWALEKEKAKLGRSEER--DK----EELEDLKFSLESQKQRNLQLNLLLEQQKQL 3269
Query: 806 MNGYQRRIKNATEKMMALVAELSMKQALTIELQKEVREKEDFIFTCNSRIEKGLPLNKEI 865
+N Q++I++ + M A+LS +Q +ELQ + ++ I +S +++ L+ ++
Sbjct: 3270 LNESQQKIES---QRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQL 3326
Query: 866 E 866
+
Sbjct: 3327 Q 3327
Score = 62.8 bits (151), Expect = 1e-09
Identities = 140/754 (18%), Positives = 305/754 (40%), Gaps = 129/754 (17%)
Query: 84 SEVQLLQ---NAKRFTEQIQQQQFHLQQADNFPEAFSTEVSKMREQLLKYQNEYNAVKER 140
SE+Q L N ++ T + +Q+ Q E + + + Q+L+ Q E +++K+R
Sbjct: 3092 SEIQALHAQMNGRKITLKREQESEKPSQ-----ELLEYNIQQKQSQMLEMQVELSSMKDR 3146
Query: 141 EFHNQYRLNSLKEEKIIIVKEFEKITKPGEMEKKMKILRESTEELRKEIMQKKLEIKNLR 200
Q +L+S EK+++ EL+ E+ Q KLE++
Sbjct: 3147 ATELQEQLSS---EKMVVA------------------------ELKSELAQTKLELETTL 3179
Query: 201 EDLASKQKQLLKEQKELEELLGHQVVLKDEVAHHQTIPVQIGKEIEKITRKKVEMEKKKI 260
+ K+L + E+++ +L D +A Q ++ +EK K E++
Sbjct: 3180 KAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDK 3239
Query: 261 VLEQEVKTLNDSLKKVENKVSAIVDEKENVIKE----VEGKRALLEIKEREHNQLVKLLE 316
+++K +S K+ +++ ++++++ ++ E +E +R L + + E L+
Sbjct: 3240 EELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQ 3299
Query: 317 LARENEATSLTERGILDLNLRNSLIDKQNYHDELSRKQREKERDFRNLRKMELLLKVSWD 376
+ E+E + E + ++L ++ H +L + + R E LLK +
Sbjct: 3300 VLLESEKVRIRE-------MSSTLDRERELHAQL--QSSDGTGQSRPPLPSEDLLK---E 3347
Query: 377 ALRQTQALHQRLLLEMEAIPKDDSTLSERRRELHKEVEVAKRNL-AQQKIISEMESKLVE 435
+Q + H R++ + K + R+++ K+ +V ++ L +Q+ +E + K+ E
Sbjct: 3348 LQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHE 3407
Query: 436 QQLAEENKLLKEQENMKELVVNLLRMTQIKIDEKEQKSKDFLKAQQKYTNIVKEMKAKDL 495
Q E+ Q +++EK Q+ Q+ I++E + ++L
Sbjct: 3408 LQSKVED-------------------LQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQEL 3448
Query: 496 EIRIHKKKKCEIYRRLREFAKLYDTIRNERNKFVNLLHKAHQKVNEIKERHKMSLN---- 551
E ++ + +Y+ L E ++ ++R + L K + E + +N
Sbjct: 3449 EREEKRESRRILYQNLNEPTTW--SLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGT 3506
Query: 552 ----ELEILRNSAVSQERKLQNSMLKHANNVTIRES-------MQNDVRKIVSKLQEM-- 598
ELE++R KLQ K + + + +Q ++ +I+ +LQ++
Sbjct: 3507 GCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTG 3566
Query: 599 KEKKEAQLNNIDRLANTIT-MIEEEMVQLRKRYEKAVQHRNESGVQLIEREEEICIFYEK 657
++ +E L + ++T + + +L + + +N+ +++ EE+I + +
Sbjct: 3567 QQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQT 3626
Query: 658 ---INIQEKMKLNGEIEIHLLEEKIQFLKMKIAEKQRQICVTQKLLPAKRSLDADLAVLQ 714
+ + LNG I I ++++ +KL K A+ V +
Sbjct: 3627 GAGRDNSSRFSLNGGANIE-----------AIIASEKEVWNREKLTLQKSLKRAEAEVYK 3675
Query: 715 IQFSQCTDRIKDLEKQFVKPDGENRARFLPGKDLTEKEMIQKLDKLELQLAKKEEKLLEK 774
++ D + Q + PD E+ +T K + K + E K
Sbjct: 3676 LKAELRNDSL----LQTLSPDSEH---------VTLKRIYGKYLRAE---------SFRK 3713
Query: 775 DFIYEQVSRLTDRLCSKTQGCKQDTLLLAKKMNG 808
IY++ L L Q C+ TL L +M G
Sbjct: 3714 ALIYQKKYLLL--LLGGFQECEDATLALLARMGG 3745
Score = 56.2 bits (134), Expect = 1e-07
Identities = 180/889 (20%), Positives = 348/889 (39%), Gaps = 142/889 (15%)
Query: 9 EKEEEEEKDEKDQEPIYAIVPTINIQDERFVDLSETPAFIFLHELHAMGKLPGTRMAALK 68
+K+ E+EK Q+ V + E F E+ F L L A +A+ K
Sbjct: 2655 KKQREKEKKRSPQD-----VEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYK 2709
Query: 69 AKYTLLHDAVMSTQESEVQLLQNAKRFTEQI-----------QQQQFHLQQA------DN 111
K L + ++ + + L ++ + + + ++ + +Q++ +
Sbjct: 2710 EKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEP 2769
Query: 112 FPEAFSTEVSKMREQLLKYQNEYNA----VKEREFHNQYRLNSLKEEKIIIVKEF-EKIT 166
P S ++ + LK + VK + EE I+ +F EKI
Sbjct: 2770 LPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIE 2829
Query: 167 KPGEMEKKMKILRESTEELRKEIMQKK--LEIKNLREDLASKQKQLL----KEQKELEEL 220
K E+ + ES E ++++ + ++ L+E+ + + + KE + EL
Sbjct: 2830 KMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPEL 2889
Query: 221 LGHQVVLKDEVAHHQTIPVQIGKEIEKITRKKVEMEKKKIVLEQEVKTLNDSL-KKVENK 279
E+ + G+ I + ++ + E E T DS KK++
Sbjct: 2890 AHSDAYQTREICSSDS-GSDWGQGIYLTHSQGFDIASEGRGEESESAT--DSFPKKIKGL 2946
Query: 280 VSAIVDEKENVIKEVEGKRALLEIKEREHNQLVKLLE-LARENEATSLTERGILDLNLRN 338
+ A+ +E V+ E + + E + + ++ E E +A T + DL +
Sbjct: 2947 LRAVHNEGMQVLSLTESPYS-----DGEDHSIQQVSEPWLEERKAYINTISSLKDLITKM 3001
Query: 339 SLIDKQNYHDELSRKQREKERDFRNLRKMELLLKVSWDALRQTQALHQRLLLEMEAIPKD 398
L + +D S + E D+R ELLL + L + L E+ A+
Sbjct: 3002 QLQREAEVYD--SSQSHESFSDWRG----ELLLALQQVFLEERSVLLAAFRTELTALGTT 3055
Query: 399 DST-----LSERRRELHKEVEVAKRNLAQQKIISEMESKLVEQQLAEENKLLKEQENMKE 453
D+ L +R +E E + A L Q A+ LL E + +
Sbjct: 3056 DAVGLLNCLEQRIQEQGVEYQAAMECL----------------QKADRRSLLSEIQAL-H 3098
Query: 454 LVVNLLRMTQIKIDEKEQKSKDFLK--AQQKYTNIVKEMKAKDLEIRIHKKKKCEIYRRL 511
+N ++T + E E+ S++ L+ QQK + +M +E+ K + E+ +L
Sbjct: 3099 AQMNGRKITLKREQESEKPSQELLEYNIQQKQS----QMLEMQVELSSMKDRATELQEQL 3154
Query: 512 RE----FAKLYDTIRNERNKFVNLLHKAHQKVNEIKERH---KMSLNELEILRNSAVSQE 564
A+L + + + L H+ + E++ K +E+ +L ++ S++
Sbjct: 3155 SSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQ 3214
Query: 565 RKLQNSMLKHANNVTIRESMQNDVRKIVSKLQEMKEKKEAQLNNIDRLANTITMIEEEMV 624
+K + +Q + K +KL +E+ + +L + L ++ ++ +
Sbjct: 3215 KKSRE--------------LQWALEKEKAKLGRSEERDKEELED---LKFSLESQKQRNL 3257
Query: 625 QLRKRYEKAVQHRNESGVQLIEREEEICIFYEKINIQEKMKLNGEIEIHLLEEKIQFLKM 684
QL E+ Q NES Q IE + + Y+ + E+ N E+++ L EK++ +M
Sbjct: 3258 QLNLLLEQQKQLLNESQ-QKIESQR---MLYDA-QLSEEQGRNLELQVLLESEKVRIREM 3312
Query: 685 KIAEKQRQICVTQKLLPAKRSLDADLAVLQIQFSQCTDRIK------DLEKQFVKPDGEN 738
L +R L A Q+Q S T + + DL K+ K E
Sbjct: 3313 S------------STLDRERELHA-----QLQSSDGTGQSRPPLPSEDLLKELQKQLEEK 3355
Query: 739 RARFLPGKDLTEKEMIQKLDKLEL-QLAKKEEKLLEKDFIYEQVSRLTDRLCSKTQGCKQ 797
+R + + TEK KLD L+ Q +K+ ++ K EQ + T+G K+
Sbjct: 3356 HSRIVELLNETEK---YKLDSLQTRQQMEKDRQVHRKTLQTEQEAN--------TEGQKK 3404
Query: 798 DTLLLAKKMNGYQRRIKNATEKMMALVAELSMKQALTIELQKEVREKED 846
L K+ QR+++ +++ L E Q + E QK+ E+E+
Sbjct: 3405 -MHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREE 3452
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 113 bits (283), Expect = 7e-25
Identities = 173/804 (21%), Positives = 364/804 (45%), Gaps = 102/804 (12%)
Query: 67 LKAKYTLLHDAVMSTQESEVQLLQNAKRFTEQIQQQQFHLQQADNFPEAFSTEVSKMREQ 126
L+A TL + ST +Q Q +Q+++Q L+ E F+ ++S ++E+
Sbjct: 245 LQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEK 304
Query: 127 LLKYQNEYNAVKEREFHNQYRLNSLKEEKIIIVKEF-----EKITKPGEMEKKMKILRES 181
+ Y+ E + K+ E N+ + +EK I++E E+ K E++ K+ +
Sbjct: 305 IKVYEMEQD--KKVENSNKEEI----QEKETIIEELNTKIIEEEKKTLELKDKLTTADKL 358
Query: 182 TEELRKEIMQKKLEIKNLREDLASKQKQLLKEQKELEELLGHQVVLKDEVAHHQTIPVQI 241
EL+++I+QK EIKN++ +L + +++ + +E+++L+G L+ I
Sbjct: 359 LGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDI 418
Query: 242 GKEIEKITRKKVEMEKKKI-------VLEQEVKTLNDSLKKVENKVSAIVDEKENVIKEV 294
+ +E+ T++K+E + ++ +++ + + + + ++E + E EN ++
Sbjct: 419 VQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSY 478
Query: 295 EGKRALLEIKEREHNQLVKLLELARENEATSLTERGILDLNLRNSLIDKQNYHDELSRKQ 354
+ + E + +KL+ +A I +LN++ D S+K+
Sbjct: 479 SN----ITVNEDQ----IKLMNVA------------INELNIK--------LQDTNSQKE 510
Query: 355 REKERDFRNLRKMELLLKVSWDALRQTQALHQRLLLEMEAIPKDDSTLSERR---RELHK 411
+ KE ++ L+L+ RQ + L + L E I + T++E+ E HK
Sbjct: 511 KLKE-------ELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHK 563
Query: 412 EVEVAKRNLAQQKIISEMESKL--------------VEQQLAEENKLLKEQENMKELVVN 457
+ + A+ SE +L +E E+N +L +E +
Sbjct: 564 SLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELE 623
Query: 458 LLRMTQIKIDEKEQKSKDFLKAQQKYTNIVKEMKAKDLEIRIHKKKKCEIYRRLREFAKL 517
LR TQ+ +E+ SK LK + + + K KD + IH K++ + + E ++
Sbjct: 624 RLR-TQLLFSHEEELSK--LKEDLEIEHRINIEKLKD-NLGIHYKQQIDGLQ--NEMSQK 677
Query: 518 YDTIRNERNKFVNLLHKAHQKVNEIKERHKMSLNELEILRNSAVSQERKLQ-NSMLKHAN 576
+T++ E++ NL+ K +Q + EI + L +L+ ++ S+E LQ N + K
Sbjct: 678 IETMQFEKD---NLITKQNQLILEISK-----LKDLQQSLVNSKSEEMTLQINELQKEIE 729
Query: 577 NVTIRESMQNDVRKIVSKLQEMKEKKEAQLNNIDR-LANTITMIEEEMVQLRKRYEKAVQ 635
+ E + + + V +LQ E E Q+ + L +E E + K +K ++
Sbjct: 730 ILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAEN-SILKDEKKTLE 788
Query: 636 HRNESGVQLIEREEEICIFYEKINIQEKMKLNGEIEIHLLEEKIQFLKMKIAEKQRQICV 695
+ + +EE IF + I + K + E EI +L E+ + LK + + +I
Sbjct: 789 DMLK--IHTPVSQEERLIFLDSIKSKSKDSV-WEKEIEILIEENEDLKQQCIQLNEEIEK 845
Query: 696 TQKLLP-AKRSLDADLAVLQIQFSQCTDRIK-DLEKQFVKPDGENRARFLPGKDLTEKEM 753
+ A+++ + + LQ +++ C ++K DLE K + E +++ K L E+
Sbjct: 846 QRNTFSFAEKNFEVNYQELQEEYA-CLLKVKDDLEDSKNKQELEYKSKL---KALNEELH 901
Query: 754 IQKLDKLELQLAKK---EEKLLEKDFIY--EQVSRLTDRLCSKTQGCKQDTLLLAKKMNG 808
+Q+++ +++ E+K + + E V + T L K + K++ L L+++++
Sbjct: 902 LQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSD 961
Query: 809 YQRRIKNATEKMMALVAEL-SMKQ 831
++K ++ L E+ S+KQ
Sbjct: 962 LSEQLKQKHGEISFLNEEVKSLKQ 985
Score = 99.8 bits (247), Expect = 1e-20
Identities = 181/820 (22%), Positives = 359/820 (43%), Gaps = 129/820 (15%)
Query: 90 QNAKRFTEQIQQQQFHLQQADNFPEAFSTEVSKMR-----EQLLKYQNEYNAVKERE--- 141
Q A+ ++ + L + E + E+ +MR E L + Q A+K+R+
Sbjct: 148 QGAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGII 207
Query: 142 FHNQYRLNSLKEEKIIIVKEFEKITKPGEMEKKMKILRESTEELRKEIMQKKLEIKNLRE 201
L + EK ++EF ++T E +K++I ++L+ + +
Sbjct: 208 TQLTANLQQARREKDETMREFLELT---EQSQKLQI---QFQQLQASETLRNSTHSSTAA 261
Query: 202 DLASKQKQLLKEQKELEELLGHQVVLKDEVAHHQTIPVQIGKEIEKITRKKVEMEKKKIV 261
DL ++Q+L Q++LEE +L+D + +QI EKI K EME+
Sbjct: 262 DLLQAKQQILTHQQQLEE---QDHLLEDYQKKKEDFTMQISFLQEKI--KVYEMEQD--- 313
Query: 262 LEQEVKTLNDSLKKVENKVSAIVDEKENVIKE-----VEGKRALLEIKEREHNQLVKLLE 316
KKVEN + EKE +I+E +E ++ LE+K++ KLL
Sbjct: 314 ------------KKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDK-LTTADKLLG 360
Query: 317 LARENEATSLTERGILDLNLRNSLIDKQNYHDELSRKQREKERDFRNLR-KMELLLKVSW 375
+E E + L L NS +K+R+ + + L +E L K +
Sbjct: 361 ELQEQIVQKNQEIKNMKLELTNS-----------KQKERQSSEEIKQLMGTVEELQKRN- 408
Query: 376 DALRQTQALHQRLLLEMEAIPKDDSTLSERRRELHKEVEVAKRNLAQQKIISEMESKLVE 435
H+ E + + + + + +L E++ + Q+I+ +M+ +L+
Sbjct: 409 ---------HKDSQFETDIVQRMEQETQRKLEQLRAELD----EMYGQQIV-QMKQELIR 454
Query: 436 QQLAEENKLLKEQENMKELVVNLLR-MTQIKIDEKEQKSKDF----LKAQQKYTNIVKEM 490
Q +A+ ++ + E N LR + I ++E + K + L + + TN KE
Sbjct: 455 QHMAQMEEMKTRHKGEME---NALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKE- 510
Query: 491 KAKDLEIRIHKKKKCEIYRRLREFAKLYDTIRNERNKFVNLLHKAHQKVNEIKERHKMSL 550
K K+ E+ + ++KC + R+L + + R + + + + K+N E HK SL
Sbjct: 511 KLKE-ELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLN---EAHK-SL 565
Query: 551 NELEILRNSAVSQERKLQNSMLKHANNVT---IRESMQNDVRKIVSKLQEMKEKKEAQLN 607
+ +E L+ VS + LKH VT I+ M + V L M E +EA+L
Sbjct: 566 STVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAV--LDRMAESQEAELE 623
Query: 608 NIDRLANTITMIEEEMVQLRKRYEKAVQHRNESGVQLIEREEEICIFYEKINIQEKMKLN 667
+ + EEE+ +L++ E ++HR + + + ++ + I Y K +++
Sbjct: 624 RL--RTQLLFSHEEELSKLKEDLE--IEHR----INIEKLKDNLGIHY-------KQQID 668
Query: 668 G-EIEIHLLEEKIQFLKMKIAEKQRQICVTQKLLPAKRSLDADLAVLQIQFSQCTDRIKD 726
G + E+ E +QF K + KQ Q+ +L + D +++ + + T +I +
Sbjct: 669 GLQNEMSQKIETMQFEKDNLITKQNQL-----ILEISKLKDLQQSLVNSKSEEMTLQINE 723
Query: 727 LEKQFVKPDGENRARFLPGKDLTEKEMIQKLDKLELQLAKKEEKLLEK--------DFIY 778
L+K+ E + + +++ E ++ K + LE Q+ +KE L EK +
Sbjct: 724 LQKEIEILRQEEKEKGTLEQEVQELQL--KTELLEKQMKEKENDLQEKFAQLEAENSILK 781
Query: 779 EQVSRLTDRLCSKTQGCKQDTLLLAKKMNGYQRRIKNAT--EKMMALVAELSMKQALTIE 836
++ L D L T +++ L+ ++ + + K++ +++ L+ E + I+
Sbjct: 782 DEKKTLEDMLKIHTPVSQEERLIF---LDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQ 838
Query: 837 LQKEV-REKEDFIFTCNSRIEKGLPLN-KEIEKEWLKVLR 874
L +E+ +++ F F EK +N +E+++E+ +L+
Sbjct: 839 LNEEIEKQRNTFSFA-----EKNFEVNYQELQEEYACLLK 873
Score = 97.8 bits (242), Expect = 4e-20
Identities = 180/911 (19%), Positives = 389/911 (42%), Gaps = 143/911 (15%)
Query: 79 MSTQESEVQLLQNAKRFTEQIQQQQFHLQQADNFPEAFSTEVSKMREQLLKYQNEYNAVK 138
+ QE + L R EQ+ + L +A+ + ++ E + Q+ + + + ++
Sbjct: 1893 LKCQEELRERLHEESRAREQLAVE---LSKAEGVIDGYADEKTLFERQIQEKTDIIDRLE 1949
Query: 139 EREFHNQYRLNSLKEEKIIIVKEFEKITKPGEMEK------KMKILRESTEELRKEIMQK 192
+ RL L+ E+ I +E E +++ E K + ++L+E TE+L KE ++
Sbjct: 1950 QELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQE-TEKLMKEKLEV 2008
Query: 193 KLEIKNLREDLASKQKQLLKEQKELEELLGHQVVLKDEV--------AHHQTIPVQIGKE 244
+ + + +R+DL QKQ+ + ++EE + + L+ E +Q + Q+ K
Sbjct: 2009 QCQAEKVRDDL---QKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKM 2065
Query: 245 IEKITRKKVEMEKKKIVLEQEVKTLNDSLKKV------ENKVSAIVDEKENVIKEVEGKR 298
+ + + ++ E ++ V +QE++ L LK V + V++ N +KE K
Sbjct: 2066 RKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKC 2125
Query: 299 ALLEIKEREHNQLVKLLELARENEATSLTERGILDLNLRNSLIDKQNYHDELSRKQREKE 358
+ L + + + + ++ NE E + +L + D++++ ++ +
Sbjct: 2126 SELLLSKEQLQR-----DIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELS-- 2178
Query: 359 RDFRNLRKMELLLKVSWDALRQTQALHQRLLLEMEAIPKDDSTLSERRRELHKEVEVAKR 418
+E+ L+ DA+ + + L ++E ++ +E ++LH ++E+ K+
Sbjct: 2179 --------LEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKK 2230
Query: 419 NLAQQKIISEMESKLVEQQLAEENKLLKEQENMKE--------LVVNLLRMTQIKIDE-K 469
+ E E+KL + + + +KE + M +++ +++ID+
Sbjct: 2231 ESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLN 2290
Query: 470 EQKSKDFLKAQQKYTNIVKEMKAK-----DLEIRIH---KKKKCEIYRRLREFAKLYDTI 521
EQ +K L+ Q K T K ++ K DLE +I ++C R E +L + I
Sbjct: 2291 EQVTK--LQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVI 2348
Query: 522 RNERNKFVNLLHKAHQKVNEIKERHKMSLNELEIL---------RNSAVSQERKLQNSML 572
+ + N+ K + + E ++L+++ + ++E ++L
Sbjct: 2349 EKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVL 2408
Query: 573 KHAN---NVTIRE--SMQNDVRKIVSKLQEMKEKK-EAQLNNI--DRLANTITMIEEEMV 624
K N N +E S++ + R+ V K+Q + E ++++ D+ + + E+ +
Sbjct: 2409 KETNFKMNQLTQELFSLKRE-RESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALK 2467
Query: 625 QLRKR-YEKAVQHRNESGVQLIE------------REEEICIFYEKINIQEKMKLNGEIE 671
L + Y K+ + + + +E ++ E+ Y++I + M+ G+ E
Sbjct: 2468 SLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQI---KDMQEQGQFE 2524
Query: 672 IHLLEEKIQFLKMKIAEKQRQICVTQKLLPA----------KRSLDADLAVLQIQ----- 716
+L++KI L+ + EK V+Q L A +++ ++ IQ
Sbjct: 2525 TEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQL 2584
Query: 717 --------FSQCTDRIKDLEKQFVKPDGENRARFLPGKDLTEKEMIQKLDKLELQLAKKE 768
S T RI +LE Q V+ + + EKE ++ +K + +KE
Sbjct: 2585 REDELGSDISALTLRISELESQVVE---------MHTSLILEKEQVEIAEK---NVLEKE 2632
Query: 769 EKLLEKDFIYE-----QVSRLTDRLCSKTQGCKQDT-LLLAKKMNGYQRRIKNATEKMMA 822
+KLLE + E Q + R + K T L + + +G+ ++ + +A
Sbjct: 2633 KKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVA 2692
Query: 823 LVAELSMKQALTIELQKEVREKEDFIFTCNSRIEKGLPLNKE---IEKEWLKVLRDEEMH 879
AEL+ + +LQ+E+ KE T + ++K L ++ KE L +L E+
Sbjct: 2693 TKAELASYKEKAEKLQEELLVKE----TNMTSLQKDLSQVRDHLAEAKEKLSILEKEDET 2748
Query: 880 ALAIAEKSQEF 890
+ ++K+ F
Sbjct: 2749 EVQESKKACMF 2759
Score = 81.6 bits (200), Expect = 3e-15
Identities = 140/762 (18%), Positives = 318/762 (41%), Gaps = 135/762 (17%)
Query: 83 ESEVQLLQNAKRFTEQIQQQQFHLQ-QADNFPEAFSTEVSKMREQLLKYQNEYNAVKERE 141
+ E+++L+ ++ ++Q+ LQ + + + + + ++E+ + + E + +K+ +
Sbjct: 725 QKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEK 784
Query: 142 --FHNQYRLNS--LKEEKIIIVKEFEKITKPGEMEKKMKILRESTEELRKEIMQKKLEIK 197
+ ++++ +EE++I + + +K EK+++IL E E+L+++ +Q EI+
Sbjct: 785 KTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIE 844
Query: 198 NLREDLASKQKQLLKEQKELEELLGHQVVLKDEVAHHQTIPVQIGKEIEKITRKKVEMEK 257
R + +K +EL+E + +KD++ + ++++E +
Sbjct: 845 KQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKN-------------KQELEYKS 891
Query: 258 KKIVLEQEVKTLNDSLKKVENKVSAIVDEKENVIKEVEGKRALLEIKEREHNQLVKLLEL 317
K L +E+ + V+ K S ++K V + +E + E+ E++ +L++ LE+
Sbjct: 892 KLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLE----MGEVVEKDTTELMEKLEV 947
Query: 318 ARENEATSLTERGILDLNLRNSLIDKQ--NYHDELSR-----KQREKERDFRNLRKMELL 370
T+R L+L+ R S + +Q H E+S K ++E++ +LR EL
Sbjct: 948 ---------TKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELE 998
Query: 371 LKVSWDALRQTQALHQRLLLEMEAIPKDDSTLSERRRELHKEVEVAKRNLAQQKIISEME 430
+ ++ + Q+ ++ ++ + T++ R E V+K N K E
Sbjct: 999 IIINHNRAENVQSCDTQVSSLLDGVV----TMTSRGAE----GSVSKVN----KSFGEES 1046
Query: 431 SKLVEQQLAEENKLLKEQENMKELVVN---------LLRMTQIKIDEKEQKSKDFLKAQQ 481
+VE +++ EN + E+ ++L+++ LR TQ ++K QK + LK++Q
Sbjct: 1047 KIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQ 1106
Query: 482 KYTNIVKEMKAKDLEIRIHKKKKCEIYRRLREFAKLYDTIRNERNKFV-----NLLHKAH 536
DL +++ ++ C ++ + + NE++K + L+
Sbjct: 1107 N-----------DLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQE 1155
Query: 537 QKVNEIKERHKMSLNELEILRNSAVSQERKLQNSMLKHANNVTIRESMQNDVRKIVSKLQ 596
+K+ E+++ H++ EL+ ++ E K + ++ KLQ
Sbjct: 1156 EKIKELQKIHQL---ELQTMKTQETGDEGK--------------------PLHLLIGKLQ 1192
Query: 597 EMKEKKEAQLNNIDRLANTITMIEEEMVQLRKRYEKAVQHRNESGVQLIEREEEICIFYE 656
+ A T+ + E + E + + SG + E E+ Y
Sbjct: 1193 K------AVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYR 1246
Query: 657 KINIQEKMKLNGEIEIHLLEEKIQFLKMKIAEKQRQICVTQKLLPAKRSLDADLAVLQIQ 716
E+ +E + L K+ E+ ++ V Q L D ++++
Sbjct: 1247 -------------YEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTD--GMKLE 1291
Query: 717 FSQCTDRIKDLEKQFVKPDGENRARFLPGKDLTEKEMIQKLDKLELQLAKKEEKLLEKDF 776
F + + + E +F+ ++ L D+ K + L LE K
Sbjct: 1292 FGE--ENLPKEETEFLSI--HSQMTNLEDIDVNHKSKLSSLQDLE------------KTK 1335
Query: 777 IYEQVSRLTDRLCSKTQGCKQDTLLLAKKMNGYQRRIKNATE 818
+ EQV L + S Q K+ +++ Q+R++ +E
Sbjct: 1336 LEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSE 1377
Score = 80.1 bits (196), Expect = 9e-15
Identities = 186/891 (20%), Positives = 377/891 (42%), Gaps = 155/891 (17%)
Query: 7 DTEKEEEEEKDEKDQEPIYAIVPTINIQDER-FVDLSE--TPAFIFLHELHAMGKLPGTR 63
D + E +++ +++E I + T I++E+ ++L + T A L EL
Sbjct: 313 DKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQE 372
Query: 64 MAALKAKYTLLHDAVMSTQESEVQLLQNAKRFTEQIQQQQFHLQQADNFPEAFSTEVSKM 123
+ +K + T ++++ E Q + K+ +++ LQ+ ++ F T++ +
Sbjct: 373 IKNMKLELT-------NSKQKERQSSEEIKQLMGTVEE----LQKRNHKDSQFETDIVQR 421
Query: 124 REQLLKYQNEYNAVKEREFHNQYRLNSLKEEKI---IIVKEFEKITKPGEMEK------- 173
EQ + + E + E + Q ++ +K+E I + E K GEME
Sbjct: 422 MEQETQRKLEQLRAELDEMYGQ-QIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSN 480
Query: 174 ------KMKILRESTEELRKEIMQKKLEIKNLREDLASKQKQLLKEQKELEELLGHQVVL 227
++K++ + EL ++ + + L+E+L ++ Q++LE+L+
Sbjct: 481 ITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFS 540
Query: 228 KDEVAH-HQTIPVQIGK----------------EIEKITRKKVEMEKKKIVLEQEVKTLN 270
++++ QTI Q K EI + + E+E K E EV
Sbjct: 541 REQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKH---EAEVTNYK 597
Query: 271 DSLKKVENKVSAIVDEK-ENVIKEVEGKRA-LLEIKEREHNQLVKLLELARENEATSLTE 328
L+ +E + +A++D E+ E+E R LL E E ++L + LE+ L +
Sbjct: 598 IKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKD 657
Query: 329 RGILDLNLRNSLIDKQNYHDELSRKQREKERDFRNL--RKMELLLKVS-WDALRQT--QA 383
L ++ + + QN E+S+K + + NL ++ +L+L++S L+Q+ +
Sbjct: 658 N--LGIHYKQQIDGLQN---EMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNS 712
Query: 384 LHQRLLLEMEAIPKDDSTLSERRRE---LHKEV-EVAKRNLAQQKIISEMESKLVEQ--Q 437
+ + L++ + K+ L + +E L +EV E+ + +K + E E+ L E+ Q
Sbjct: 713 KSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQ 772
Query: 438 LAEENKLLKEQENMKELVVNLLRMTQ-----IKIDEKEQKSKDFLKAQQKYTNIVKEMKA 492
L EN +LK+++ E ++ + I +D + KSKD + ++ I +
Sbjct: 773 LEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDL 832
Query: 493 KDLEIRIHKK------------KKCEI-YRRLRE----FAKLYDTIRNERNKFVNLLHKA 535
K I+++++ K E+ Y+ L+E K+ D + + +NK L +K+
Sbjct: 833 KQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNK-QELEYKS 891
Query: 536 HQK-VNEIKERHKMSLNELEILRNSAVSQERKL--------------QNSMLKHANNVTI 580
K +NE E H +N + S+V E K + L VT
Sbjct: 892 KLKALNE--ELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTK 949
Query: 581 RESMQNDVRKIVSKLQEMKEKKEAQLNNIDRLANTITMIEEEMVQLRKR-YEKAVQHRNE 639
RE ++ R +S L E ++K +++ ++ ++ E+E V LR R E + H
Sbjct: 950 REKLELSQR--LSDLSEQLKQKHGEISFLNEEVKSLKQ-EKEQVSLRCRELEIIINHNRA 1006
Query: 640 SGVQ--------LIEREEEICIFYEKINIQEKMKLNGEIEIHLLEEKIQFLKMKIAEKQR 691
VQ L++ + + ++ + K GE ++E+K+ F M + E+ +
Sbjct: 1007 ENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESK 1066
Query: 692 QICVTQKLLPA--------------------------------KRSLDADLAVLQIQFSQ 719
Q + LP+ + ++A L + +S
Sbjct: 1067 QEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYST 1126
Query: 720 CTDRIKD-LEKQFVKPDGENRARFLPGKDLTEKEMIQKLDKLELQLAKKEE 769
D++++ +E + K + + ++ KE +QK+ +LELQ K +E
Sbjct: 1127 HVDQVREYMENEKDKALCSLKEELIFAQEEKIKE-LQKIHQLELQTMKTQE 1176
Score = 75.5 bits (184), Expect = 2e-13
Identities = 168/841 (19%), Positives = 335/841 (39%), Gaps = 146/841 (17%)
Query: 183 EELRKEIMQKKLEIKNLREDLASKQKQL-LKEQKELEELLGHQVVLKDEVAHHQTIPVQI 241
EE +K++ K ++ R+ A Q K+QK+ + K +V+ H + +
Sbjct: 4 EERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSS----KHDVSAHHDLNIDQ 59
Query: 242 GKEIEKITRKKVEMEKKKIVLEQEVKTLNDS---------LKKVENKVSAIVDEKENVIK 292
+ E +E I ++TL+ ++E+++S D+ +
Sbjct: 60 SQCNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSS--- 116
Query: 293 EVEGKRALLEIKEREHNQLVKLLELARENEA---TSLTERGILDLN-----LRNSLIDKQ 344
EV G ++ K L RE E S +E+G D + + L KQ
Sbjct: 117 EVNGCSFVMRTG--------KPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQ 168
Query: 345 NYHDELSRKQREKERDF-----RNLRKMELLLKVSWDALRQTQALHQRLLLEMEAIPKDD 399
+ +EL+R+ E + + L++ E +K + Q A Q+ E + ++
Sbjct: 169 HEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREF 228
Query: 400 STLSERRRELHKEVEVAKRN----------LAQQKIISEMESKLVEQQLAEENKLLKEQE 449
L+E+ ++L + + + + A + ++ + +QQL E++ LL++ +
Sbjct: 229 LELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQ 288
Query: 450 NMKELVVNLLRMTQ--IKIDEKEQKSK----DFLKAQQKYTNIVKEMKAKDLEIRIHKKK 503
KE + Q IK+ E EQ K + + Q+K T I++E+ K +E +KK
Sbjct: 289 KKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKET-IIEELNTKIIE---EEKK 344
Query: 504 KCEIYRRLREFAKLY-----------DTIRNERNKFVNLLHKAHQKVNEIKE-------- 544
E+ +L KL I+N + + N K Q EIK+
Sbjct: 345 TLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEEL 404
Query: 545 ---RHKMSLNELEILRNSAVSQERKLQN--SMLKHANNVTIRESMQNDVRKIVSKLQEMK 599
HK S E +I++ +RKL+ + L I + Q +R+ +++++EMK
Sbjct: 405 QKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMK 464
Query: 600 EKKEAQLNNIDRLANTITMIEEEMVQLRKRYEKAVQHRNESGVQLIEREEEI-CIFYEKI 658
+ + ++ N R + IT+ E+++ + + ++ Q + +EE+ I EK
Sbjct: 465 TRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKC 524
Query: 659 NIQEKMKLNGEIEIHLLEEKIQFLKMKIAEKQRQICVTQKLLPAKRSLDAD--------- 709
+Q +++ E E+ E+IQ + IAE++ ++ K L L A+
Sbjct: 525 ALQRQLEDLVE-ELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRK 583
Query: 710 ----------------LAVLQIQFSQCTDRIKD--------LEKQFVKPDGENRARFLPG 745
L +L+ + + DR+ + L Q + E ++
Sbjct: 584 ELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKED 643
Query: 746 KDLTEKEMIQKL--------------------DKLELQLAKKEEKLLEKDFIYEQVSRLT 785
++ + I+KL K+E +K+ + +++ + ++S+L
Sbjct: 644 LEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLK 703
Query: 786 DRLCSKTQGCKQDTLLLAKKMNGYQRRIKNATEKMMALVAELSMKQALTIELQKEVREKE 845
D S ++ L ++ ++ ++ L E+ Q T L+K+++EKE
Sbjct: 704 DLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKE 763
Query: 846 DFIFTCNSRIEKGLPLNKE--IEKEWLKVLRDE-EMHALAIAEKSQEFLEADNRQLPNGV 902
N EK L E I K+ K L D ++H E+ FL++ + + V
Sbjct: 764 ------NDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSV 817
Query: 903 Y 903
+
Sbjct: 818 W 818
Score = 74.7 bits (182), Expect = 4e-13
Identities = 158/862 (18%), Positives = 366/862 (42%), Gaps = 78/862 (9%)
Query: 80 STQESEVQLLQNAKRFTE-QIQQQQFHLQQADNFPEAFSTEVSKM--------REQLLKY 130
S++++ Q F E ++ Q Q Q + F E + +E LL
Sbjct: 1473 SSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSN 1532
Query: 131 QNEYNAVKEREFHNQYRLNSLKEEKIIIVKEF---EKITKPGEMEKKMKILRESTEELRK 187
+ ++ + ++ ++K IV++ E + +++ + E E++R+
Sbjct: 1533 SDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQ 1592
Query: 188 EIMQKKLEIKNLREDLASKQKQLLKEQKELEELLGHQVV-LKDEVAHHQTIPVQ-IGKEI 245
E++++ E + E L + ++ Q+E +E L ++ L ++A +I + + E
Sbjct: 1593 ELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSER 1652
Query: 246 EKITRKKVEMEKKKIVLEQE--VKTLNDSLKKVENKVSAIVDEKENVIKEVEGKRALLEI 303
E++ +++E K+ + +E L +S + +N + +E KE E R ++
Sbjct: 1653 ERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDV 1712
Query: 304 K-----------EREHNQLVK-LLELARENEATSLT----ERGILDLNLRN----SLI-- 341
++ +N+L+K LLE+ + A T GILD + ++ SLI
Sbjct: 1713 PPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWR 1772
Query: 342 ------DKQNYHDELSRKQREKERDFRNLRKMELLLKVSWDALRQTQALHQRLLLEMEAI 395
K H+E +R E + + + + L QRL+ A
Sbjct: 1773 SEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAG 1832
Query: 396 PKDDSTLSERRRELHKEVEVAKRNLAQQKIISEMESKLVEQQLAEENKLLKEQENMKELV 455
+ D E + ++ A L + ISE S+L E + +L++E K+
Sbjct: 1833 TEIDPENEELMLNISSRLQAAVEKLLE--AISETSSQL-EHAKVTQTELMRESFRQKQEA 1889
Query: 456 VNLLRMTQIKIDEKEQKSKDFLKAQQKYTNIVKEMKAKDLEIRIHKKKKCEIYRRLREFA 515
L+ +E ++ + +A+++ + E+ + I + +K R+++E
Sbjct: 1890 TESLKCQ----EELRERLHEESRAREQ---LAVELSKAEGVIDGYADEKTLFERQIQEKT 1942
Query: 516 KLYDTIRNERNKFVNLLHKAHQKVNEIKERHKMSLNELEILRNSAVSQERKL---QNSML 572
+ D + E N L + + +I+E ++ + E ++ A E++L ++
Sbjct: 1943 DIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLM 2002
Query: 573 KHANNVTIR-ESMQNDVRKIVSKLQEMKEKKEAQLNNIDRLANTITM-IEEEMVQLRKRY 630
K V + E +++D++K V L+ E++ ++ +++ NT M + ++ L K+
Sbjct: 2003 KEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQL 2062
Query: 631 EKAVQHRNESGVQLIEREEEICIFYEKI-NIQEKMKLNGEIEIHLLEEKIQFLKMKIAEK 689
EK + +E Q I+RE E +F ++I +++++K+ + + E + + ++
Sbjct: 2063 EKMRKFLDE---QAIDREHERDVFQQEIQKLEQQLKVVPRFQ-PISEHQTREVEQLANHL 2118
Query: 690 QRQICVTQKLLPAKRSLDADLAVLQIQFSQCTDRIKDLEKQFVKPDGENRARFLPGKDLT 749
+ + +LL +K L D+ + + R+++LE+ + D ++ +L+
Sbjct: 2119 KEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELS 2178
Query: 750 EKEMIQ----KLDKLELQLAKKEEKLLEKDFIYEQVSRLTDRLCSKTQGCKQDTLLLAKK 805
+ +Q +D+ E ++ EE+L + E + +L + + K+++ ++
Sbjct: 2179 LEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQE 2238
Query: 806 MNGYQRRIKNATEKMMALVAELSM-----KQALTIELQKEVREKEDFIFTCNSRIEK--- 857
+ + K+ EK+ + E + L + + ++EKE I N ++ K
Sbjct: 2239 LEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQ 2298
Query: 858 --GLPLNKEIEKEWLKVLRDEE 877
+ + ++ +E +++RD E
Sbjct: 2299 QLKITTDNKVIEEKNELIRDLE 2320
Score = 64.7 bits (156), Expect = 4e-10
Identities = 162/901 (17%), Positives = 371/901 (41%), Gaps = 168/901 (18%)
Query: 62 TRMAALKAKYTLLHDAVMSTQESEVQLLQNAKRF-TEQIQQQQFHLQQADNFPEAFSTEV 120
TR+ L++ + D ++ +++ +Q +F TE +Q++ +LQ+ A +
Sbjct: 2491 TRLLQLESTVSA-KDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVS 2549
Query: 121 SKMREQLLKY----QNEYNAVKEREFHNQYRLNSLKEEKI------IIVKEFEKITKPGE 170
E + +Y Q+ E E N LN L+E+++ + ++ E ++ E
Sbjct: 2550 QIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVE 2609
Query: 171 MEKKMKILRESTEELRKEIMQKK---LEIKNLREDLASKQKQLLKEQK------------ 215
M + + +E E K +++K+ LE++ L E KQ++ K++
Sbjct: 2610 MHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTE 2669
Query: 216 ------------ELEELLGHQVVLKDEVAHHQTIPVQIGKEIEKITRKKVEMEKKKIVLE 263
ELE L V K E+A ++ ++ EK+ + + E L+
Sbjct: 2670 LFHSNEESGFFNELEALRAESVATKAELASYK-------EKAEKLQEELLVKETNMTSLQ 2722
Query: 264 QEVKTLNDSLKKVENKVSAIVDEKENVIKEVEGKRALL------EIKEREHNQLVKLLEL 317
+++ + D L + + K+S + EKE+ + E K+A + ++ + +Q L++
Sbjct: 2723 KDLSQVRDHLAEAKEKLSIL--EKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKI 2780
Query: 318 ARENEATS-LTERGILDLNLRNSLIDKQNYHDELSRKQREKERDFRNLRKMELLLKVSWD 376
+ N+ L + + +NL++ ++ E+ + EK + L E+L S
Sbjct: 2781 SSSNQTPQILVKNAGIQINLQSECSSEEV--TEIISQFTEKIEKMQELHAAEILDMESRH 2838
Query: 377 ALRQTQALHQRLLLEMEAIPKDDSTLSE-----RRRELHKEVEVAKRNLAQQKIISEMES 431
+ +T+ L + + ++ + ++ TL R +E E+A + Q + I +S
Sbjct: 2839 -ISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDS 2897
Query: 432 ----------------KLVEQQLAEENKLLKEQ--ENMKELV-------VNLLRMTQIKI 466
+ + EE++ + + +K L+ + +L +T+
Sbjct: 2898 GSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPY 2957
Query: 467 DEKE-----QKSKDFLKAQQKYTNIVKEMKAKDLEIRIHKKKKCEIYRRLREFAKLYDTI 521
+ E Q S+ +L+ ++ Y N + +K DL ++ +++ E+Y
Sbjct: 2958 SDGEDHSIQQVSEPWLEERKAYINTISSLK--DLITKMQLQREAEVYDS----------- 3004
Query: 522 RNERNKFVNLLHKAHQKVNEIKERHKMSLNELEILRNSAVSQERKLQNSMLKHANNVTIR 581
++H+ ++ + ++L ++ + S + + + + L + V +
Sbjct: 3005 -----------SQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLL 3053
Query: 582 ESMQNDVRKIVSKLQEMKEKKEAQLNNIDRLANTITMIEEEMVQLRKRYEKAVQHRNESG 641
++ ++QE + +A + + + + E + + + K R +
Sbjct: 3054 NCLEQ-------RIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQES 3106
Query: 642 VQLIEREEEICIFYEKINIQEKMKLNGEIEIHL---------LEEKIQFLKMKIAEKQRQ 692
E+ + + Y NIQ+K E+++ L L+E++ KM +AE + +
Sbjct: 3107 ----EKPSQELLEY---NIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSE 3159
Query: 693 ICVT----QKLLPAKRSLDADLAVLQIQFSQCTDRIKDLEKQFVKPDGENRARFLPGKDL 748
+ T + L A+ +L +++ TD + L ++R
Sbjct: 3160 LAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSR--------- 3210
Query: 749 TEKEMIQKLDKLELQLAKKEEKLLEKDFIYEQVSRLTDRLCSKTQGCKQDTLLLAKK--- 805
E+ L+K + +L + EE+ +K E++ L L S+ Q Q LLL ++
Sbjct: 3211 ---ELQWALEKEKAKLGRSEER--DK----EELEDLKFSLESQKQRNLQLNLLLEQQKQL 3261
Query: 806 MNGYQRRIKNATEKMMALVAELSMKQALTIELQKEVREKEDFIFTCNSRIEKGLPLNKEI 865
+N Q++I++ + M A+LS +Q +ELQ + ++ I +S +++ L+ ++
Sbjct: 3262 LNESQQKIES---QRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQL 3318
Query: 866 E 866
+
Sbjct: 3319 Q 3319
Score = 62.8 bits (151), Expect = 1e-09
Identities = 140/754 (18%), Positives = 305/754 (40%), Gaps = 129/754 (17%)
Query: 84 SEVQLLQ---NAKRFTEQIQQQQFHLQQADNFPEAFSTEVSKMREQLLKYQNEYNAVKER 140
SE+Q L N ++ T + +Q+ Q E + + + Q+L+ Q E +++K+R
Sbjct: 3084 SEIQALHAQMNGRKITLKREQESEKPSQ-----ELLEYNIQQKQSQMLEMQVELSSMKDR 3138
Query: 141 EFHNQYRLNSLKEEKIIIVKEFEKITKPGEMEKKMKILRESTEELRKEIMQKKLEIKNLR 200
Q +L+S EK+++ EL+ E+ Q KLE++
Sbjct: 3139 ATELQEQLSS---EKMVVA------------------------ELKSELAQTKLELETTL 3171
Query: 201 EDLASKQKQLLKEQKELEELLGHQVVLKDEVAHHQTIPVQIGKEIEKITRKKVEMEKKKI 260
+ K+L + E+++ +L D +A Q ++ +EK K E++
Sbjct: 3172 KAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDK 3231
Query: 261 VLEQEVKTLNDSLKKVENKVSAIVDEKENVIKE----VEGKRALLEIKEREHNQLVKLLE 316
+++K +S K+ +++ ++++++ ++ E +E +R L + + E L+
Sbjct: 3232 EELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQ 3291
Query: 317 LARENEATSLTERGILDLNLRNSLIDKQNYHDELSRKQREKERDFRNLRKMELLLKVSWD 376
+ E+E + E + ++L ++ H +L + + R E LLK +
Sbjct: 3292 VLLESEKVRIRE-------MSSTLDRERELHAQL--QSSDGTGQSRPPLPSEDLLK---E 3339
Query: 377 ALRQTQALHQRLLLEMEAIPKDDSTLSERRRELHKEVEVAKRNL-AQQKIISEMESKLVE 435
+Q + H R++ + K + R+++ K+ +V ++ L +Q+ +E + K+ E
Sbjct: 3340 LQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHE 3399
Query: 436 QQLAEENKLLKEQENMKELVVNLLRMTQIKIDEKEQKSKDFLKAQQKYTNIVKEMKAKDL 495
Q E+ Q +++EK Q+ Q+ I++E + ++L
Sbjct: 3400 LQSKVED-------------------LQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQEL 3440
Query: 496 EIRIHKKKKCEIYRRLREFAKLYDTIRNERNKFVNLLHKAHQKVNEIKERHKMSLN---- 551
E ++ + +Y+ L E ++ ++R + L K + E + +N
Sbjct: 3441 EREEKRESRRILYQNLNEPTTW--SLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGT 3498
Query: 552 ----ELEILRNSAVSQERKLQNSMLKHANNVTIRES-------MQNDVRKIVSKLQEM-- 598
ELE++R KLQ K + + + +Q ++ +I+ +LQ++
Sbjct: 3499 GCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTG 3558
Query: 599 KEKKEAQLNNIDRLANTIT-MIEEEMVQLRKRYEKAVQHRNESGVQLIEREEEICIFYEK 657
++ +E L + ++T + + +L + + +N+ +++ EE+I + +
Sbjct: 3559 QQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQT 3618
Query: 658 ---INIQEKMKLNGEIEIHLLEEKIQFLKMKIAEKQRQICVTQKLLPAKRSLDADLAVLQ 714
+ + LNG I I ++++ +KL K A+ V +
Sbjct: 3619 GAGRDNSSRFSLNGGANIE-----------AIIASEKEVWNREKLTLQKSLKRAEAEVYK 3667
Query: 715 IQFSQCTDRIKDLEKQFVKPDGENRARFLPGKDLTEKEMIQKLDKLELQLAKKEEKLLEK 774
++ D + Q + PD E+ +T K + K + E K
Sbjct: 3668 LKAELRNDSL----LQTLSPDSEH---------VTLKRIYGKYLRAE---------SFRK 3705
Query: 775 DFIYEQVSRLTDRLCSKTQGCKQDTLLLAKKMNG 808
IY++ L L Q C+ TL L +M G
Sbjct: 3706 ALIYQKKYLLL--LLGGFQECEDATLALLARMGG 3737
Score = 56.2 bits (134), Expect = 1e-07
Identities = 180/889 (20%), Positives = 348/889 (39%), Gaps = 142/889 (15%)
Query: 9 EKEEEEEKDEKDQEPIYAIVPTINIQDERFVDLSETPAFIFLHELHAMGKLPGTRMAALK 68
+K+ E+EK Q+ V + E F E+ F L L A +A+ K
Sbjct: 2647 KKQREKEKKRSPQD-----VEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYK 2701
Query: 69 AKYTLLHDAVMSTQESEVQLLQNAKRFTEQI-----------QQQQFHLQQA------DN 111
K L + ++ + + L ++ + + + ++ + +Q++ +
Sbjct: 2702 EKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEP 2761
Query: 112 FPEAFSTEVSKMREQLLKYQNEYNA----VKEREFHNQYRLNSLKEEKIIIVKEF-EKIT 166
P S ++ + LK + VK + EE I+ +F EKI
Sbjct: 2762 LPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIE 2821
Query: 167 KPGEMEKKMKILRESTEELRKEIMQKK--LEIKNLREDLASKQKQLL----KEQKELEEL 220
K E+ + ES E ++++ + ++ L+E+ + + + KE + EL
Sbjct: 2822 KMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPEL 2881
Query: 221 LGHQVVLKDEVAHHQTIPVQIGKEIEKITRKKVEMEKKKIVLEQEVKTLNDSL-KKVENK 279
E+ + G+ I + ++ + E E T DS KK++
Sbjct: 2882 AHSDAYQTREICSSDS-GSDWGQGIYLTHSQGFDIASEGRGEESESAT--DSFPKKIKGL 2938
Query: 280 VSAIVDEKENVIKEVEGKRALLEIKEREHNQLVKLLE-LARENEATSLTERGILDLNLRN 338
+ A+ +E V+ E + + E + + ++ E E +A T + DL +
Sbjct: 2939 LRAVHNEGMQVLSLTESPYS-----DGEDHSIQQVSEPWLEERKAYINTISSLKDLITKM 2993
Query: 339 SLIDKQNYHDELSRKQREKERDFRNLRKMELLLKVSWDALRQTQALHQRLLLEMEAIPKD 398
L + +D S + E D+R ELLL + L + L E+ A+
Sbjct: 2994 QLQREAEVYD--SSQSHESFSDWRG----ELLLALQQVFLEERSVLLAAFRTELTALGTT 3047
Query: 399 DST-----LSERRRELHKEVEVAKRNLAQQKIISEMESKLVEQQLAEENKLLKEQENMKE 453
D+ L +R +E E + A L Q A+ LL E + +
Sbjct: 3048 DAVGLLNCLEQRIQEQGVEYQAAMECL----------------QKADRRSLLSEIQAL-H 3090
Query: 454 LVVNLLRMTQIKIDEKEQKSKDFLK--AQQKYTNIVKEMKAKDLEIRIHKKKKCEIYRRL 511
+N ++T + E E+ S++ L+ QQK + +M +E+ K + E+ +L
Sbjct: 3091 AQMNGRKITLKREQESEKPSQELLEYNIQQKQS----QMLEMQVELSSMKDRATELQEQL 3146
Query: 512 RE----FAKLYDTIRNERNKFVNLLHKAHQKVNEIKERH---KMSLNELEILRNSAVSQE 564
A+L + + + L H+ + E++ K +E+ +L ++ S++
Sbjct: 3147 SSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQ 3206
Query: 565 RKLQNSMLKHANNVTIRESMQNDVRKIVSKLQEMKEKKEAQLNNIDRLANTITMIEEEMV 624
+K + +Q + K +KL +E+ + +L + L ++ ++ +
Sbjct: 3207 KKSRE--------------LQWALEKEKAKLGRSEERDKEELED---LKFSLESQKQRNL 3249
Query: 625 QLRKRYEKAVQHRNESGVQLIEREEEICIFYEKINIQEKMKLNGEIEIHLLEEKIQFLKM 684
QL E+ Q NES Q IE + + Y+ + E+ N E+++ L EK++ +M
Sbjct: 3250 QLNLLLEQQKQLLNESQ-QKIESQR---MLYDA-QLSEEQGRNLELQVLLESEKVRIREM 3304
Query: 685 KIAEKQRQICVTQKLLPAKRSLDADLAVLQIQFSQCTDRIK------DLEKQFVKPDGEN 738
L +R L A Q+Q S T + + DL K+ K E
Sbjct: 3305 S------------STLDRERELHA-----QLQSSDGTGQSRPPLPSEDLLKELQKQLEEK 3347
Query: 739 RARFLPGKDLTEKEMIQKLDKLEL-QLAKKEEKLLEKDFIYEQVSRLTDRLCSKTQGCKQ 797
+R + + TEK KLD L+ Q +K+ ++ K EQ + T+G K+
Sbjct: 3348 HSRIVELLNETEK---YKLDSLQTRQQMEKDRQVHRKTLQTEQEAN--------TEGQKK 3396
Query: 798 DTLLLAKKMNGYQRRIKNATEKMMALVAELSMKQALTIELQKEVREKED 846
L K+ QR+++ +++ L E Q + E QK+ E+E+
Sbjct: 3397 -MHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREE 3444
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 112 bits (279), Expect = 2e-24
Identities = 165/860 (19%), Positives = 370/860 (43%), Gaps = 101/860 (11%)
Query: 119 EVSKMREQLLKYQNEYNAVKEREFHNQYRLNSLKEEKIII--------VKEFEKITKPGE 170
E+ K+ L Q + + + +L+SL+ E + + VK+ + T +
Sbjct: 572 EIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQ 631
Query: 171 MEKKMKILRESTEELRKEIMQKKLEIKNLREDLASKQKQLLKEQKELEELLGHQVVLKDE 230
EK+ + L EELR +++Q + E +L+ ++A + Q Q+EL E + L+ E
Sbjct: 632 YEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESE 691
Query: 231 VAHHQTIPVQIGKEIEKITRKKVEMEKKKIVLEQEVKTLNDSLKKVENKVSAIVDEKENV 290
+ + + + K++E+ + K LEQE+ N+ ++ +E ++ E E +
Sbjct: 692 MTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINT---EHEKI 748
Query: 291 IKEVEGKRALLEIKEREHNQLVKLLELARENEATSLTERGILDLNLRNSLIDKQNYHDEL 350
E + + + +E + ++ LE E + E+ L+ +I KQ++ + L
Sbjct: 749 CLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESL 808
Query: 351 SRKQREKERDFR--NLRKMELLLKVSWDALRQTQALHQ----------RLLLEMEAIPKD 398
R E + + + N++K E L + +T + Q L+L + + +
Sbjct: 809 DRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGN 868
Query: 399 DSTLSERRRELHKEVEVAKRNLAQQKIISEMESKLVEQQLAEENKLLKEQENMKELVV-- 456
++ ++ +EV ++ L KI + + EQ + ++ L ++Q+ +++ +
Sbjct: 869 KEKFEKQLKKKSEEVYCLQKEL---KIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRN 925
Query: 457 NLLRMTQIKIDEKEQKSKDFLKAQ-----QKYTNIVKEMKAKDLEIRIHKKKKCEIYRRL 511
L TQ K++++ K + L+ Q +K + ++ ++ E + ++K E+
Sbjct: 926 GELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTA 985
Query: 512 REFAKLYDTIRNERNKFVNLLHKAHQKVNEIK---ERHKMSLNELEILRNSAVSQERKLQ 568
R+ ++ E +++ L K +++ +K E M L++L+++ + ++ K
Sbjct: 986 RQ-------VKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKT 1038
Query: 569 NSM-----LKHANNVTIRESMQ-------------NDVRKIVSKLQEMKEKKEAQLNNID 610
N++ L+H+ + E++Q +++ + +LQE+++ + +++
Sbjct: 1039 NAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLE 1098
Query: 611 RLANTITMIEEEMVQLRKRYEKAVQHRNESGVQLIEREEEI-----CIFYEKINIQEKMK 665
TI + E+ + + E Q E L ER E+ + + + I+E
Sbjct: 1099 EKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREH-- 1156
Query: 666 LNGEIE--IHLLEEKIQFLKMKIAEKQRQI-CVTQKLLPAKRSL----------DADLAV 712
GE+E I LE ++ ++++ E +QI + KL AK L + +++
Sbjct: 1157 -RGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQ 1215
Query: 713 LQIQFSQCTDRIKDLEKQFVKPDGENRARFLPGKDLTEKEMIQKLDKLELQLAKKEEKLL 772
L+ + + R+K++E + + ++ DL Q+L Q+ +L
Sbjct: 1216 LKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLG-----QELRLTREQVQNSHTELA 1270
Query: 773 EKDFIYEQVSRLTDRLCSKTQGCKQDTL-------LLAKKMNGYQRRIKNATEKMMALVA 825
E Q R +RL S+ + KQ + LA+++ + R + +M A +
Sbjct: 1271 EARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIK 1330
Query: 826 EL-----SMKQALTIELQKEVREKEDFIFTCNSRIEKGLPLNKEIEKEWLKV--LRDEEM 878
+L S+K+A +E+ + + +S+ LN+++EK L++ +D
Sbjct: 1331 KLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKLELEEAQDTVS 1390
Query: 879 HALAIAEKSQEFLEADNRQL 898
+ + E +EA N L
Sbjct: 1391 NLHQQVQDRNEVIEAANEAL 1410
Score = 90.1 bits (222), Expect = 9e-18
Identities = 171/922 (18%), Positives = 385/922 (41%), Gaps = 154/922 (16%)
Query: 75 HDAVMSTQESEVQLLQNAKRFTEQIQQQQFHLQQADNFPEAFSTEVSKMREQLLKYQNEY 134
++A+ + +E Q K+ E++++ Q + + E +++E+ Y++E
Sbjct: 357 NEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQERCGLYKSEL 416
Query: 135 NAVKEREFHNQYRLNSLKEE-KIIIVKEFEKITKPGEMEKKMKILRESTEELRKEIMQKK 193
+KE+ + N+ KE+ +I+ VK E + + E + + L ES E + EI++ K
Sbjct: 417 EILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKL-ESELENKDEILRDK 475
Query: 194 LEIKN----LREDLASKQKQLLKEQKELE---------ELLGHQVVLKDEVAHHQTI--- 237
+ N L+ +A++ ++L Q+E+E E + Q+ LK E+ ++
Sbjct: 476 FSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSK 535
Query: 238 --------------------PVQIGKEIEKITRKKVEMEKKKI-----VLEQEVKTLNDS 272
+ I + K+ K+ E++K L Q + T NDS
Sbjct: 536 YQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLITCNDS 595
Query: 273 LKKVENKVSAIVDEK-----ENVIKEV--EGKRALLEIKEREHNQLV--------KLLEL 317
+ +K+S++ E V + V + + + + E+E +LV KL+++
Sbjct: 596 --QESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQI 653
Query: 318 ARENE--ATSLTERGILDLNLRNSLIDKQNYHDELSRKQREKERDFRNLRKMELLLKVSW 375
EN ++ R ++ L++K + +L + +K L K V++
Sbjct: 654 EAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAY 713
Query: 376 DALRQTQA-LHQRLLLEMEAIPKDDSTLSERRRELHKEVEVAKRNLAQQKIISEMESKLV 434
++ A L Q L+ + E I ++ ++ ++ E AK+ +Q E + + +
Sbjct: 714 SSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERL 773
Query: 435 EQQLAEENKLLKEQENMKELVV--------NLLRMTQIKIDEKEQKSKDFLKAQQKYTNI 486
E QL ++++ KEQE ++ +L + ++ + K + K+ +K + +
Sbjct: 774 EAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKAL 833
Query: 487 VKEMKAKDLEIRIHKKKKCEIYRRLREFAKLYDTIRNERNKFVNLLHKAHQKVNEIKERH 546
++ + +++R EI + E + + + KF L K ++V +++
Sbjct: 834 QNQVSEETIKVR-QLDSALEICK--EELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKEL 890
Query: 547 KMSLNELE-------ILRNSAVSQERKLQNSMLKHANNVTIRESMQNDVRKIVSKLQEMK 599
K+ + L+ IL+++ Q++ LQ +++ + ++ V K+ +LQ+ +
Sbjct: 891 KIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQR 950
Query: 600 EKKEAQLN--------------------------------NIDRLANTITMIEEEMVQLR 627
E +L +D+ ++ +E+E++ L+
Sbjct: 951 ESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLK 1010
Query: 628 KRYEKAVQHRNESGVQLIEREEEICIFYEKINIQEKMKLNGEIEI-------HLLEEKIQ 680
+ E H ++ + L + + E+ + EK++ + E E+ +LE ++Q
Sbjct: 1011 RDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQ 1070
Query: 681 ----FLKMKIAEKQRQICVTQKLLPAKRSLDADLAVLQIQFSQCTDRIKDLEKQFVKPDG 736
LK + + Q V QK + + L + +C I+D +++ ++ D
Sbjct: 1071 NAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQ 1130
Query: 737 ---------ENRARFLPGKDLTEK----EMIQKLDKLELQLAKKEEKLLEKDFIYEQVSR 783
+ RA + D+T + EM QK+ KLE L K E +L E + +Q+
Sbjct: 1131 ALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECN---KQIES 1187
Query: 784 LTDRLCSKTQGCKQDTLLLAKKMNGYQRRIKNATEKMMALVAELSMKQALTIELQKEVRE 843
L D+L + + ++ ++ + +++ L E+ Q E++ ++E
Sbjct: 1188 LNDKLQNAKEQLREKEFIMLQN-----------EQEISQLKKEIERTQQRMKEMESVMKE 1236
Query: 844 KEDFIFTCNSRIEKGLPLNKEI 865
+E +I T + ++ + L +E+
Sbjct: 1237 QEQYIAT---QYKEAIDLGQEL 1255
Score = 79.3 bits (194), Expect = 2e-14
Identities = 196/961 (20%), Positives = 381/961 (39%), Gaps = 185/961 (19%)
Query: 50 LHELHAMGKLPGTRMAALKAKYTLLHDAVMSTQESEVQLLQNAKRFTEQIQQQQFHLQQA 109
L++L T+ +L K+ +H + ++ ++V +L++A++ + + +Q
Sbjct: 238 LNKLRQQNACLVTQNHSLMTKFESIHFELTQSR-AKVSMLESAQQQAASVPILE---EQI 293
Query: 110 DNFPEAFSTEVSKMREQLLKYQNEYNAVKEREFHNQYRLNSLKEEKIIIVKEFEKITKPG 169
N S + +RE K + V E+E L KEE I + + + TK G
Sbjct: 294 INLEAEVSAQDKVLREAENKLEQSQKMVIEKE----QSLQESKEECIKLKVDLLEQTKQG 349
Query: 170 EM-EKKMKILRESTEELRKEIMQKKLEIKNLREDLASKQKQL-------LKEQKELEELL 221
+ E++ + EEL K Q K ++ E + ++++ L KE K L+E
Sbjct: 350 KRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQERC 409
Query: 222 G----HQVVLKDEV------------------AHHQTIPVQIGKEIEKITRKKVEMEKKK 259
G +LK+++ + + Q+ + + I + + E+E K
Sbjct: 410 GLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENKD 469
Query: 260 IVLEQEVKTLNDSLKKVENKVSAIVDEKENVIKEVEGKRALLEIKEREHNQLVKLLEL-- 317
+L + +N++ ++++ +V+A + + +E+E R L E+ +QL EL
Sbjct: 470 EILRDKFSLMNEN-RELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLKRELFG 528
Query: 318 --------------ARENEATSLTERGILDLN-LRNSLIDK----QNYHDELSRKQREKE 358
+E+ E L ++ LR L K Q H L+ Q +
Sbjct: 529 FKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQS 588
Query: 359 ----RDFRNLRKMELL----LKVSWDAL-------------RQTQALHQRLLLEMEAIPK 397
D + K+ L +K+ + +Q + QRL+ +E +
Sbjct: 589 LITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRT 648
Query: 398 DDSTLSERRRELHKEVEVAKRNLAQQKIISEM------ESKLVEQQLAEENKLLKEQENM 451
+ +L +V +A R Q I E+ SKL + + ++LL ++ +
Sbjct: 649 KLIQIEAENSDL--KVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQL 706
Query: 452 KELVVNLLRMTQIKIDEKEQKSKDFLKAQQKYTNIVKE--------MKAKDLEIRIHKKK 503
+E +V + + +++ + K + TNI E KAK + + HK+
Sbjct: 707 EEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEM 766
Query: 504 KCEIYRRLREFAKLYDTIRNERNKFVNLLHKAHQKVNEIKERHKMSLNELEILRNSAVSQ 563
+ +I RL + D E+ K +++L Q+ K+ H SL+ L + +
Sbjct: 767 EKQI-ERLEAQLEKKDQQFKEQEKTMSML----QQDIICKQHHLESLDRLLTESKGEMKK 821
Query: 564 ERKLQNSMLKHANNVTIRESMQNDVRKIVSKLQEMKEKKEAQLN----NIDRLANTITMI 619
E ++ LK N E+++ VR++ S L+ KE+ LN N ++ +
Sbjct: 822 ENMKKDEALKALQNQVSEETIK--VRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKK 879
Query: 620 EEEMVQLRKRYE---KAVQHRNESGVQLIEREEEICIFYEKINIQEKMKLNGEIE----- 671
EE+ L+K + ++Q +E V L ++ ++ +Q++ NGE+E
Sbjct: 880 SEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQ-----QQQMLQQETIRNGELEDTQTK 934
Query: 672 ----IHLLEEKIQFLKMKIAEKQRQI---CVT---------QKLLPAKRSLDADLAVLQI 715
+ LE+++Q + AEK R++ C + QK++ L ++I
Sbjct: 935 LEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVI----ELTGTARQVKI 990
Query: 716 QFSQCTDRIKDLEKQF--VKPDGENRARFLPGKDLTEKEMIQKLDKLELQLAKKEEKLLE 773
+ Q + + +EK+ +K DGEN+A L D+ LD+ + +L KK + E
Sbjct: 991 EMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMI-------LDQTKTELEKKTNAVKE 1043
Query: 774 KDFIYEQVSRLTDRLCSKTQGCKQDTLLLAKKMNGYQRRIKNATEKMMALVAELSMKQAL 833
L K + + + A +K L EL
Sbjct: 1044 ----------------------------LEKLQHSTETELTEALQKREVLETELQNAHGE 1075
Query: 834 TIELQKEVREKEDFIFTCNSRIEKGLPLNKEIEKEWLKVLRDEEMHALAIAEKSQEFLEA 893
++++E D + +E+ K++ E LR+ +M I +K QE LE
Sbjct: 1076 LKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAE----LRECKME---IEDKKQELLEM 1128
Query: 894 D 894
D
Sbjct: 1129 D 1129
Score = 75.9 bits (185), Expect = 2e-13
Identities = 127/604 (21%), Positives = 261/604 (43%), Gaps = 105/604 (17%)
Query: 67 LKAKYTLLHDAVMSTQESEVQLLQNAKRFTEQIQQQQFHLQQADNFPEAFSTEVSKMREQ 126
L+ + + + ++ T E V L ++ + +QQ+ + ++ +VSK+ ++
Sbjct: 886 LQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQE 945
Query: 127 LLKYQNEYNAVKEREFHNQYRLNSLKEEKIIIVKEFEKITKPGEMEKKMKILRESTEELR 186
L K Q E +A K R+ EEK E ++ K+ K++ EL
Sbjct: 946 LQK-QRESSAEKLRKM----------EEKC------ESAAHEADL-KRQKVI-----ELT 982
Query: 187 KEIMQKKLEIKNLREDLASKQKQLLKEQKELEELLGHQVVLKDEVAHHQTIPVQIGKEIE 246
Q K+E+ +E+L+ +K+++ +++ E H ++ I Q E+E
Sbjct: 983 GTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMH-------LSQLDMILDQTKTELE 1035
Query: 247 KITRKKVEMEKKKIVLEQEVKTLNDSLKKVENKVSAIVDEKENVIKEVEGK-RALLEIKE 305
K T E+EK + E E L ++L+K E + E +N E++ R L E+++
Sbjct: 1036 KKTNAVKELEKLQHSTETE---LTEALQKRE----VLETELQNAHGELKSTLRQLQELRD 1088
Query: 306 REHNQLVKLLELARENEATSLTERGILDLNLRNSLIDKQNYHDELSRKQREKERDFRNLR 365
+++ +L+ E + T++ + L LR ++ ++ EL L
Sbjct: 1089 -----VLQKAQLSLEEKYTTIKD---LTAELRECKMEIEDKKQEL-------------LE 1127
Query: 366 KMELLLKVSWDALRQTQALHQRLLLEMEAIPKDDSTLSERRRELHKEVEVAKRNLAQQKI 425
+ L + +W+ L+Q A L D T+ E R E+ +++ + L +
Sbjct: 1128 MDQALKERNWE-LKQRAAQVTHL----------DMTIREHRGEMEQKIIKLEGTLEK--- 1173
Query: 426 ISEMESKLVEQQLAEEN-KLLKEQENMKELVVNLLRMTQIKIDEKEQKSKDFLKAQQKYT 484
SE+E K +Q+ N KL +E ++E +L+ Q E Q K+ + QQ+
Sbjct: 1174 -SELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQ----EISQLKKEIERTQQRMK 1228
Query: 485 NIVKEMKAKDLEIRIHKKKKCEIYRRLREFAKLYDTIRNERNKFVNLLHKAHQKVNEIKE 544
+ MK ++ I K+ ++ + LR T +N L HQ+V +E
Sbjct: 1229 EMESVMKEQEQYIATQYKEAIDLGQELRL------TREQVQNSHTELAEARHQQVQAQRE 1282
Query: 545 RHKMSLNELEILRNSAVSQERKLQ-NSMLKHANNVTIRES-----MQNDVRKIVSKLQEM 598
++S +ELE ++ +S+E+ N + + +RE+ MQ +++K+ ++++ +
Sbjct: 1283 IERLS-SELEDMKQ--LSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESL 1339
Query: 599 KEKKEAQL-----------NNIDRLANTITMIEEEMVQLRKRYEKAVQHRNESGVQLIER 647
KE ++ + D +++ + E++ + + E+A + Q+ +R
Sbjct: 1340 KEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKLELEEAQDTVSNLHQQVQDR 1399
Query: 648 EEEI 651
E I
Sbjct: 1400 NEVI 1403
Score = 45.8 bits (107), Expect = 2e-04
Identities = 38/228 (16%), Positives = 107/228 (46%), Gaps = 10/228 (4%)
Query: 74 LHDAVMSTQESEVQLLQNAKRFTE---QIQQQQFHLQQADNFPEAFSTEVSKMREQLLKY 130
L +A +E E +LQN + ++ +I++ Q +++ ++ + ++ ++ +
Sbjct: 1192 LQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDL 1251
Query: 131 QNEYNAVKEREFHNQYRLNSLKEEKIIIVKEFEKITKPGEMEKKMKILREST---EELRK 187
E +E+ ++ L + +++ +E E+++ E+E ++ +E L +
Sbjct: 1252 GQELRLTREQVQNSHTELAEARHQQVQAQREIERLSS--ELEDMKQLSKEKDAHGNHLAE 1309
Query: 188 EIMQKKLEIKNLREDLASKQKQLLKEQKELEELLGHQVVLKDEVAHHQTIPVQIGKEIEK 247
E+ K+ +L + ++ K+L E + L+E +++ E +H + +
Sbjct: 1310 ELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQE--NHAKWKISADSQKSS 1367
Query: 248 ITRKKVEMEKKKIVLEQEVKTLNDSLKKVENKVSAIVDEKENVIKEVE 295
+ + ++EK K+ LE+ T+++ ++V+++ I E ++ + E
Sbjct: 1368 VQQLNEQLEKAKLELEEAQDTVSNLHQQVQDRNEVIEAANEALLTKGE 1415
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 111 bits (277), Expect = 4e-24
Identities = 213/929 (22%), Positives = 395/929 (42%), Gaps = 170/929 (18%)
Query: 67 LKAKYTLLHDAVMSTQ--ESEVQLLQNAKRFTEQIQQQQ--------FHLQQADNFPEAF 116
LKAK LHD M +++ L E Q+Q + L+Q
Sbjct: 387 LKAK---LHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISR----- 438
Query: 117 STEVSKMREQLLKYQ-NEYNAVK--EREFHNQYRLNSLKEEKIIIVKEFEKITKPGEMEK 173
++E+S+ ++ L ++ NE + + + E NQ +++E + + +K +MEK
Sbjct: 439 TSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEK 498
Query: 174 KMKILRESTEELRKEIMQKKLEIKN---LREDLASKQKQLLKEQKELEELLGHQVVLKDE 230
+ + L + E L EI+Q+K ++N L +DL ++ QL K + L E Q+ + ++
Sbjct: 499 ENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQ 558
Query: 231 VAHHQTIPVQIGKEIEKITRKKVEMEKKKIVLEQEVKTLNDSLKKVENKVSAIVDEKENV 290
H V ++ R ++ E + +E+E K L++S+K+ +K+S I EK +
Sbjct: 559 ENEHLNQTVSSLRQ-----RSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQI 613
Query: 291 IKEVE-----GKRA-----LLEIKEREHNQLVKLL------------------ELARENE 322
KE+E G+RA L E+E+ L K + EL REN
Sbjct: 614 KKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENR 673
Query: 323 ATSLTERGILDLNLR-------NSLIDKQNYH---------------DELSRKQREKERD 360
T +L + NS +D++N +L + +E E +
Sbjct: 674 KLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESE 733
Query: 361 FRNLRKMELLLKVSWDALRQTQALHQRLLLEMEAIPKDDSTLSERRRELHKEV------- 413
L+K LLK S+ + + +Q L +E + + K +++ ++L E+
Sbjct: 734 KEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMEN 793
Query: 414 EVAKRNLAQQKIIS------EMESKLVEQ----------QLAEENKLLKEQENMKELVVN 457
+ ++NL + KI S E E+K +EQ QL +ENK L++Q +K+
Sbjct: 794 QTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKD---T 850
Query: 458 LLRMTQIKIDEKEQKSKDFLKAQQKYTNIVKE--MKAKDLEIRIHKKKKCEIYRRLREFA 515
L +KI E+++K K I KE ++ K+LE K+ E+ +R
Sbjct: 851 TLEENNVKIGNLEKENKTL----SKEIGIYKESCVRLKELE-----KENKELVKRATIDI 901
Query: 516 KLYDTIRNERNKFVNLLHKAHQKVNEIK----ERHKMSLNELEILRNSAVSQER-KLQNS 570
K T+R + V+ K Q N+++ E K+ LN+ +L + + +R KL S
Sbjct: 902 KTLVTLRED---LVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLES 958
Query: 571 MLKHANNVTIRESMQNDVRKIVSKLQEMKEKKEAQLN-NIDRLANTITMIEEEMVQLRKR 629
L+ T+++S+ E+KE+K A L ++ N + +E+ ++K
Sbjct: 959 KLES----TLKKSL------------EIKEEKIAALEARLEESTNYNQQLRQELKTVKKN 1002
Query: 630 YEKAVQHRNESGV----QLIEREEEICIFYEKINIQEKMKLNGE-IEIHLLEEKIQFLKM 684
YE Q ++E + I E+ + +E +K+ IE+ +Q
Sbjct: 1003 YEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQ---- 1058
Query: 685 KIAEKQRQICVTQKLLPAKRSLDADLAVLQIQFSQCTDRIKDLEKQFVKPDGENRARFLP 744
AEKQ ++L +L A + LQ Q ++ L+ Q K EN
Sbjct: 1059 --AEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQ 1116
Query: 745 GKDLTEKE---MIQK--LDKLELQLAKKEEKL------LEKDFIYEQVSRLTDRLCSKTQ 793
L + +IQ+ L+ + K+ E L L KD +E++ L +R S+ +
Sbjct: 1117 STSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKD--HEKLELLHERQASEYE 1174
Query: 794 G--CKQDTLLLA-KKMNGYQRRIKNATEKMMALVAEL-SMKQALTIELQKEVREKEDFIF 849
K TL A K + R +++ +++ +L +++ L +E +K + E ++
Sbjct: 1175 SLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNH-E 1233
Query: 850 TCNSRIEKGLPLNKEIEKEWLKVLRDEEM 878
T + +K N + + ++L++ E+
Sbjct: 1234 TVAAEYKKLCGENDRLNHTYSQLLKETEV 1262
Score = 90.1 bits (222), Expect = 9e-18
Identities = 167/790 (21%), Positives = 338/790 (42%), Gaps = 121/790 (15%)
Query: 180 ESTEELRKEIMQKKLEIKNLREDLASKQKQLLKEQKELEELLGHQVVLKDE---VAHHQT 236
ES + L E+ K +I+ LR++L K +QLL ++ELE++ L+ E +
Sbjct: 244 ESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDAR 303
Query: 237 IPVQIGKEIEKITRKKVEMEKKKIVLEQEVKTLNDSLKKVENKVSAIVDEKEN------- 289
E++ + K V ++K LE EV + L +E + + + KE+
Sbjct: 304 SARMYRDELDALREKAVRVDK----LESEVSRYKERLHDIEFYKARVEELKEDNQVLLET 359
Query: 290 ---VIKEVEGKRAL-----------LEIKEREHNQLV-------KLLELARENEATSLTE 328
+ ++EG RA L++K + H+ + K+ EL EN + +
Sbjct: 360 KTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQ 419
Query: 329 RGILDLNLRNSL-IDKQNYHDELSRKQREKERDFRNLRKMELLLKVSWDALRQTQALHQR 387
+ +D +L +++ + ELS ++ N LLK+ + T+ + +
Sbjct: 420 KQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTV-EE 478
Query: 388 LLLEMEAIPKDDSTLSERRRE---LHKEVEVAKRNLAQQKIISEMESKLVEQQLAEENKL 444
L ++++ + S + + +E L K+VE+ + + Q+K + L + + E+ +L
Sbjct: 479 LRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQL 538
Query: 445 LKEQENMKELVVNLLRMTQIKIDEKEQ----------KSKDFLKAQQKYTNIVKEMKAKD 494
K E ++E N R QIKI E+E + + + A+ + +I KE K
Sbjct: 539 EKTIETLRE---NSER--QIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILH 593
Query: 495 LEIRIHKKKKCEIYRRLREFAKLYDTIRNERNKFVNLLHKAH--QKVNEIKERH----KM 548
I+ K +I R+ K + + + + L ++ H +K NE+ ++ K+
Sbjct: 594 ESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKI 653
Query: 549 SLNELEIL--RNSAVSQERKLQNSMLKHANNVTIR-ESMQNDVRKIVSKLQEMKEKKEAQ 605
+ ++E L NS + +E + L N+T + ES++ + ++ + E++
Sbjct: 654 TCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELR------ 707
Query: 606 LNNIDRLANTITMIEEEMVQLRKRYEKAVQHRNESGVQLI----EREEEICIFYEKINIQ 661
N++ L ++ +QL + ++ + + + G++L+ ++ E + + Y+ ++I+
Sbjct: 708 -RNVESL--KCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIE 764
Query: 662 ----EKMKLNGEIEIHLLEEKIQFLKMKIAEKQRQICVTQKLLPAKRSLDADLAVLQIQF 717
+K N +I LE ++Q L+M+ Q+ + + L+ + L+ +
Sbjct: 765 NQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQET 824
Query: 718 SQCTDRIKDLEKQFVKPDGENRARFLPGKDLTEKEMIQKLDKLELQLAKKEEKLLEKDF- 776
SQ K LEK + + + KD T +E K+ LE KE K L K+
Sbjct: 825 SQLEKDKKQLEK-----ENKRLRQQAEIKDTTLEENNVKIGNLE-----KENKTLSKEIG 874
Query: 777 IY-EQVSRLTDRLCSKTQGCKQDTL----------------LLAKKMNGYQRRIKNATEK 819
IY E RL + + K+ T+ L ++MN ++ + EK
Sbjct: 875 IYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEK 934
Query: 820 M-----MALVAELS-------MKQALTIELQKEVREKEDFIFTCNSRIEKGLPLNKEIEK 867
+ L E S ++ L L+K + KE+ I +R+E+ N+++ +
Sbjct: 935 IGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQ 994
Query: 868 EWLKVLRDEE 877
E V ++ E
Sbjct: 995 ELKTVKKNYE 1004
Score = 80.1 bits (196), Expect = 9e-15
Identities = 106/502 (21%), Positives = 231/502 (46%), Gaps = 62/502 (12%)
Query: 70 KYTLLHDAVMSTQESEVQLLQNAKRFTEQIQQQQFHLQQADNFPEAFSTEVSKMREQLLK 129
+Y LL + ST + +++ + E+I + L+++ N+ + ++R++L
Sbjct: 952 RYKLLESKLESTLKKSLEIKE------EKIAALEARLEESTNYNQ-------QLRQELKT 998
Query: 130 YQNEYNAVKEREFHNQYRLNSLKEEKIIIVKEFEKITKPGEMEKKMKILRESTEELRKEI 189
+ Y A+K+R+ EE++ V+ I+ GE K + +E+T EL K +
Sbjct: 999 VKKNYEALKQRQ----------DEERM--VQSSPPIS--GEDNKWERESQETTRELLK-V 1043
Query: 190 MQKKLEIKNLREDLASKQKQLLKEQKELEELLGHQVVLKDEVAHHQTIPVQIGKEIEKIT 249
+ +E++ L + +KQ LK Q + E + + + QT+ +Q +
Sbjct: 1044 KDRLIEVERNNATLQA-EKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQ 1102
Query: 250 RKKVEMEKKKIVLEQEVKTLNDSLKKVENKVSAIVDEKENVIKEVEGKRALLEIKEREHN 309
K+++E L + +L + ++ + S++ +E E+VIKE E ++L + ++H
Sbjct: 1103 NAKLQVENS--TLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHE 1160
Query: 310 QLVKLLELARENEATSLTERGILDLNLRNSLIDKQNYHDELSRKQREKERDFRNLRKMEL 369
+L L E + +++ G L +N ++ ++ D ++ ++K + L +E
Sbjct: 1161 KLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQ----LEDLEK 1216
Query: 370 LLKVSWDALRQTQALHQRLLLEMEAIPKDDSTLSERRRELHKEVEVAKRNLAQQKIISEM 429
+LKV + + H+ + E + + ++ L+ +L KE EV + + K +
Sbjct: 1217 MLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLN- 1275
Query: 430 ESKLVEQQLAEENKLLKEQENMKELVVNLLR-----MTQIK--IDEKEQKSKDFLKA--Q 480
SKL + +L E LKEQ ++ L ++Q+K ++E+ + D ++
Sbjct: 1276 NSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLML 1335
Query: 481 QKYTNIVKEMKAKDL----------EIRIHKKKKCEIYRRLREFAKLYD-TIRNERNKFV 529
Q T + + M++KDL ++ +++K ++ ++ + K YD + R ++
Sbjct: 1336 QNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWI 1395
Query: 530 NL----LHKAHQKVNEIKERHK 547
L L K+ + +N +ER K
Sbjct: 1396 TLKMRKLIKSKKDIN--RERQK 1415
Score = 42.0 bits (97), Expect = 0.003
Identities = 86/474 (18%), Positives = 198/474 (41%), Gaps = 40/474 (8%)
Query: 448 QENMKELVVNLLRMTQIKIDEKEQKSKDFLKAQQKYTNI------------------VKE 489
QE+++ L+ N+ + IDE+++ S+ ++ ++ + +K
Sbjct: 183 QEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKR 242
Query: 490 MKAK---DLEIRIHKKKKCEIYRRLRE-FAKLYDTIRNERNKFVNLLHKAHQKVNEIKER 545
+++ +E+ K K + + L E +L D + + L + +N + +
Sbjct: 243 TESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDA 302
Query: 546 H--KMSLNELEILRNSAVSQERKLQNSMLKH---ANNVTIRESMQNDVRKIVSKLQEMKE 600
+M +EL+ LR AV + KL++ + ++ +++ ++ ++++ L E K
Sbjct: 303 RSARMYRDELDALREKAVRVD-KLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKT 361
Query: 601 KKEAQLNNIDRLANTITMIEEEMVQLRKRYEKAVQHRNESGVQLIEREEE--ICIFYEKI 658
E QL ++ + +E+E +QL+ + R+ ++ E EE +K
Sbjct: 362 MLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQ 421
Query: 659 NIQEKMKLNGEIEIHLLEEKIQFLKMKIAEKQRQICVTQKLLPAKRSLDADLAVLQIQFS 718
++ E + L E+E ++ K + + +LL + + L +
Sbjct: 422 SMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEME-NQSLTKTVEELR 480
Query: 719 QCTDRIKDLEKQFVKPDGENRARFLPGKDLTEKEMIQKLDKLELQLAKKEEKLLEKDFIY 778
D ++ + +K + EN+ R ++ E E++Q+ L+ ++ + EK +
Sbjct: 481 TTVDSVEGNASKILKMEKENQ-RLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLE 539
Query: 779 EQVSRLTDRLCSKTQGCKQDTLLLAKKMNGYQRRIKNATEKMMALVAELSMKQALTIELQ 838
+ + L + + + +Q+ L + ++ ++R + + E A V ++ + + E
Sbjct: 540 KTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAE---ARVKDIEKENKILHESI 596
Query: 839 KEVREKEDFIFTCNSRIEKGLPLNKEIEKEWLKVLRDEEMHALAIAEKSQEFLE 892
KE K I +I+K L KE + E + L +E H EK E L+
Sbjct: 597 KETSSKLSKIEFEKRQIKKELEHYKE-KGERAEELENELHH----LEKENELLQ 645
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 109 bits (273), Expect = 1e-23
Identities = 210/928 (22%), Positives = 392/928 (42%), Gaps = 167/928 (17%)
Query: 67 LKAKYTLLHDAVMSTQ--ESEVQLLQNAKRFTEQIQQQQ--------FHLQQADNFPEAF 116
LKAK LHD M +++ L E Q+Q + L+Q
Sbjct: 387 LKAK---LHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISR----- 438
Query: 117 STEVSKMREQLLKYQ-NEYNAVK--EREFHNQYRLNSLKEEKIIIVKEFEKITKPGEMEK 173
++E+S+ ++ L ++ NE + + + E NQ +++E + + +K +MEK
Sbjct: 439 TSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEK 498
Query: 174 KMKILRESTEELRKEIMQKKLEIKN---LREDLASKQKQLLKEQKELEELLGHQVVLKDE 230
+ + L + E L EI+Q+K ++N L +DL ++ QL K + L E Q+ + ++
Sbjct: 499 ENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQ 558
Query: 231 VAHHQTIPVQIGKEIEKITRKKVEMEKKKIVLEQEVKTLNDSLKKVENKVSAIVDEKENV 290
H V ++ R ++ E + +E+E K L++S+K+ +K+S I EK +
Sbjct: 559 ENEHLNQTVSSLRQ-----RSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQI 613
Query: 291 IKEVE-----GKRA-----LLEIKEREHNQLVKLL------------------ELARENE 322
KE+E G+RA L E+E+ L K + EL REN
Sbjct: 614 KKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENR 673
Query: 323 ATSLTERGILDLNLR-------NSLIDKQNYH---------------DELSRKQREKERD 360
T +L + NS +D++N +L + +E E +
Sbjct: 674 KLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESE 733
Query: 361 FRNLRKMELLLKVSWDALRQTQALHQRLLLEMEAIPKDDSTLSERRRELHKEV------- 413
L+K LLK S+ + + +Q L +E + + K +++ ++L E+
Sbjct: 734 KEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMEN 793
Query: 414 EVAKRNLAQQKIIS------EMESKLVEQ----------QLAEENKLLKEQENMKELVVN 457
+ ++NL + KI S E E+K +EQ QL +ENK L++Q +K+
Sbjct: 794 QTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKD---T 850
Query: 458 LLRMTQIKIDEKEQKSKDFLKAQQKYTNIVKE--MKAKDLEIRIHKKKKCEIYRRLREFA 515
L +KI E+++K K I KE ++ K+LE K+ E+ +R
Sbjct: 851 TLEENNVKIGNLEKENKTL----SKEIGIYKESCVRLKELE-----KENKELVKRATIDI 901
Query: 516 KLYDTIRNERNKFVNLLHKAHQKVNEIK----ERHKMSLNELEILRNSAVSQERKLQNSM 571
K T+R + V+ K Q N+++ E K+ LN+ +L + E+ +S
Sbjct: 902 KTLVTLRED---LVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHD-----EQSTDDSR 953
Query: 572 LKHANNVTIRESMQNDVRKIVSKLQEMKEKKEAQLN-NIDRLANTITMIEEEMVQLRKRY 630
K +++ + + K E+KE+K A L ++ N + +E+ ++K Y
Sbjct: 954 YK---------LLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNY 1004
Query: 631 EKAVQHRNESGV----QLIEREEEICIFYEKINIQEKMKLNGE-IEIHLLEEKIQFLKMK 685
E Q ++E + I E+ + +E +K+ IE+ +Q
Sbjct: 1005 EALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQ----- 1059
Query: 686 IAEKQRQICVTQKLLPAKRSLDADLAVLQIQFSQCTDRIKDLEKQFVKPDGENRARFLPG 745
AEKQ ++L +L A + LQ Q ++ L+ Q K EN
Sbjct: 1060 -AEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQS 1118
Query: 746 KDLTEKE---MIQK--LDKLELQLAKKEEKL------LEKDFIYEQVSRLTDRLCSKTQG 794
L + +IQ+ L+ + K+ E L L KD +E++ L +R S+ +
Sbjct: 1119 TSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKD--HEKLELLHERQASEYES 1176
Query: 795 --CKQDTLLLA-KKMNGYQRRIKNATEKMMALVAEL-SMKQALTIELQKEVREKEDFIFT 850
K TL A K + R +++ +++ +L +++ L +E +K + E ++ T
Sbjct: 1177 LISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNH-ET 1235
Query: 851 CNSRIEKGLPLNKEIEKEWLKVLRDEEM 878
+ +K N + + ++L++ E+
Sbjct: 1236 VAAEYKKLCGENDRLNHTYSQLLKETEV 1263
Score = 89.7 bits (221), Expect = 1e-17
Identities = 167/791 (21%), Positives = 338/791 (42%), Gaps = 122/791 (15%)
Query: 180 ESTEELRKEIMQKKLEIKNLREDLASKQKQLLKEQKELEELLGHQVVLKDE---VAHHQT 236
ES + L E+ K +I+ LR++L K +QLL ++ELE++ L+ E +
Sbjct: 244 ESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDAR 303
Query: 237 IPVQIGKEIEKITRKKVEMEKKKIVLEQEVKTLNDSLKKVENKVSAIVDEKEN------- 289
E++ + K V ++K LE EV + L +E + + + KE+
Sbjct: 304 SARMYRDELDALREKAVRVDK----LESEVSRYKERLHDIEFYKARVEELKEDNQVLLET 359
Query: 290 ---VIKEVEGKRAL-----------LEIKEREHNQLV-------KLLELARENEATSLTE 328
+ ++EG RA L++K + H+ + K+ EL EN + +
Sbjct: 360 KTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQ 419
Query: 329 RGILDLNLRNSL-IDKQNYHDELSRKQREKERDFRNLRKMELLLKVSWDALRQTQALHQR 387
+ +D +L +++ + ELS ++ N LLK+ + T+ + +
Sbjct: 420 KQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTV-EE 478
Query: 388 LLLEMEAIPKDDSTLSERRRE---LHKEVEVAKRNLAQQKIISEMESKLVEQQLAEENKL 444
L ++++ + S + + +E L K+VE+ + + Q+K + L + + E+ +L
Sbjct: 479 LRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQL 538
Query: 445 LKEQENMKELVVNLLRMTQIKIDEKEQ----------KSKDFLKAQQKYTNIVKEMKAKD 494
K E ++E N R QIKI E+E + + + A+ + +I KE K
Sbjct: 539 EKTIETLRE---NSER--QIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILH 593
Query: 495 LEIRIHKKKKCEIYRRLREFAKLYDTIRNERNKFVNLLHKAH--QKVNEIKERH----KM 548
I+ K +I R+ K + + + + L ++ H +K NE+ ++ K+
Sbjct: 594 ESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKI 653
Query: 549 SLNELEIL--RNSAVSQERKLQNSMLKHANNVTIR-ESMQNDVRKIVSKLQEMKEKKEAQ 605
+ ++E L NS + +E + L N+T + ES++ + ++ + E++
Sbjct: 654 TCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELR------ 707
Query: 606 LNNIDRLANTITMIEEEMVQLRKRYEKAVQHRNESGVQLI----EREEEICIFYEKINIQ 661
N++ L ++ +QL + ++ + + + G++L+ ++ E + + Y+ ++I+
Sbjct: 708 -RNVESL--KCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIE 764
Query: 662 ----EKMKLNGEIEIHLLEEKIQFLKMKIAEKQRQICVTQKLLPAKRSLDADLAVLQIQF 717
+K N +I LE ++Q L+M+ Q+ + + L+ + L+ +
Sbjct: 765 NQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQET 824
Query: 718 SQCTDRIKDLEKQFVKPDGENRARFLPGKDLTEKEMIQKLDKLELQLAKKEEKLLEKDF- 776
SQ K LEK + + + KD T +E K+ LE KE K L K+
Sbjct: 825 SQLEKDKKQLEK-----ENKRLRQQAEIKDTTLEENNVKIGNLE-----KENKTLSKEIG 874
Query: 777 IY-EQVSRLTDRLCSKTQGCKQDTL----------------LLAKKMNGYQRRIKNATEK 819
IY E RL + + K+ T+ L ++MN ++ + EK
Sbjct: 875 IYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEK 934
Query: 820 M-----MALVAELS--------MKQALTIELQKEVREKEDFIFTCNSRIEKGLPLNKEIE 866
+ L E S ++ L L+K + KE+ I +R+E+ N+++
Sbjct: 935 IGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLR 994
Query: 867 KEWLKVLRDEE 877
+E V ++ E
Sbjct: 995 QELKTVKKNYE 1005
Score = 82.8 bits (203), Expect = 1e-15
Identities = 112/511 (21%), Positives = 234/511 (45%), Gaps = 66/511 (12%)
Query: 70 KYTLLHDAVMSTQESEVQLLQNAKRFT---------EQIQQQQFHLQQADNFPEAFSTEV 120
K LLHD ST +S +LL++ T E+I + L+++ N+ +
Sbjct: 939 KERLLHDE-QSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQ------ 991
Query: 121 SKMREQLLKYQNEYNAVKEREFHNQYRLNSLKEEKIIIVKEFEKITKPGEMEKKMKILRE 180
++R++L + Y A+K+R+ EE++ V+ I+ GE K + +E
Sbjct: 992 -QLRQELKTVKKNYEALKQRQ----------DEERM--VQSSPPIS--GEDNKWERESQE 1036
Query: 181 STEELRKEIMQKKLEIKNLREDLASKQKQLLKEQKELEELLGHQVVLKDEVAHHQTIPVQ 240
+T EL K + + +E++ L + +KQ LK Q + E + + + QT+ +Q
Sbjct: 1037 TTRELLK-VKDRLIEVERNNATLQA-EKQALKTQLKQLETQNNNLQAQILALQRQTVSLQ 1094
Query: 241 IGKEIEKITRKKVEMEKKKIVLEQEVKTLNDSLKKVENKVSAIVDEKENVIKEVEGKRAL 300
+ K+++E L + +L + ++ + S++ +E E+VIKE E ++L
Sbjct: 1095 EQNTTLQTQNAKLQVENS--TLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSL 1152
Query: 301 LEIKEREHNQLVKLLELARENEATSLTERGILDLNLRNSLIDKQNYHDELSRKQREKERD 360
+ ++H +L L E + +++ G L +N ++ ++ D ++ ++K +
Sbjct: 1153 YDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQ- 1211
Query: 361 FRNLRKMELLLKVSWDALRQTQALHQRLLLEMEAIPKDDSTLSERRRELHKEVEVAKRNL 420
L +E +LKV + + H+ + E + + ++ L+ +L KE EV + +
Sbjct: 1212 ---LEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDH 1268
Query: 421 AQQKIISEMESKLVEQQLAEENKLLKEQENMKELVVNLLR-----MTQIK--IDEKEQKS 473
K + SKL + +L E LKEQ ++ L ++Q+K ++E+ +
Sbjct: 1269 KNLKSLLN-NSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHL 1327
Query: 474 KDFLKA--QQKYTNIVKEMKAKDL----------EIRIHKKKKCEIYRRLREFAKLYD-T 520
D ++ Q T + + M++KDL ++ +++K ++ ++ + K YD +
Sbjct: 1328 LDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPS 1387
Query: 521 IRNERNKFVNL----LHKAHQKVNEIKERHK 547
R ++ L L K+ + +N +ER K
Sbjct: 1388 PPRRRGNWITLKMRKLIKSKKDIN--RERQK 1416
Score = 42.0 bits (97), Expect = 0.003
Identities = 86/474 (18%), Positives = 198/474 (41%), Gaps = 40/474 (8%)
Query: 448 QENMKELVVNLLRMTQIKIDEKEQKSKDFLKAQQKYTNI------------------VKE 489
QE+++ L+ N+ + IDE+++ S+ ++ ++ + +K
Sbjct: 183 QEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKR 242
Query: 490 MKAK---DLEIRIHKKKKCEIYRRLRE-FAKLYDTIRNERNKFVNLLHKAHQKVNEIKER 545
+++ +E+ K K + + L E +L D + + L + +N + +
Sbjct: 243 TESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDA 302
Query: 546 H--KMSLNELEILRNSAVSQERKLQNSMLKH---ANNVTIRESMQNDVRKIVSKLQEMKE 600
+M +EL+ LR AV + KL++ + ++ +++ ++ ++++ L E K
Sbjct: 303 RSARMYRDELDALREKAVRVD-KLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKT 361
Query: 601 KKEAQLNNIDRLANTITMIEEEMVQLRKRYEKAVQHRNESGVQLIEREEE--ICIFYEKI 658
E QL ++ + +E+E +QL+ + R+ ++ E EE +K
Sbjct: 362 MLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQ 421
Query: 659 NIQEKMKLNGEIEIHLLEEKIQFLKMKIAEKQRQICVTQKLLPAKRSLDADLAVLQIQFS 718
++ E + L E+E ++ K + + +LL + + L +
Sbjct: 422 SMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEME-NQSLTKTVEELR 480
Query: 719 QCTDRIKDLEKQFVKPDGENRARFLPGKDLTEKEMIQKLDKLELQLAKKEEKLLEKDFIY 778
D ++ + +K + EN+ R ++ E E++Q+ L+ ++ + EK +
Sbjct: 481 TTVDSVEGNASKILKMEKENQ-RLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLE 539
Query: 779 EQVSRLTDRLCSKTQGCKQDTLLLAKKMNGYQRRIKNATEKMMALVAELSMKQALTIELQ 838
+ + L + + + +Q+ L + ++ ++R + + E A V ++ + + E
Sbjct: 540 KTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAE---ARVKDIEKENKILHESI 596
Query: 839 KEVREKEDFIFTCNSRIEKGLPLNKEIEKEWLKVLRDEEMHALAIAEKSQEFLE 892
KE K I +I+K L KE + E + L +E H EK E L+
Sbjct: 597 KETSSKLSKIEFEKRQIKKELEHYKE-KGERAEELENELHH----LEKENELLQ 645
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 107 bits (268), Expect = 4e-23
Identities = 173/848 (20%), Positives = 355/848 (41%), Gaps = 104/848 (12%)
Query: 119 EVSKMREQLLKYQNEYNAVKEREFHNQYRLNSLKEEKIIIVKEFEKITKPGEMEKKMKIL 178
+VS+ E+++ + E V+E++ + RL ++ + ++ E K+ +++ + ++
Sbjct: 839 QVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAE--KLQLQEQLQAETELC 896
Query: 179 RESTEELRKEIMQKKLEIKNLREDLASK--------------QKQLLKEQKELEELLGHQ 224
E+ EELR + KK E++ + DL ++ +K++ + +ELEE
Sbjct: 897 AEA-EELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEE----- 950
Query: 225 VVLKDEVAHHQTIPVQIGKEIEKIT--RKKVEMEKKKIVLEQEVKTLNDSLKKVENKVSA 282
L++E + Q + ++EK+T K ++E+++I+LE + L K +E++++
Sbjct: 951 -QLEEEESARQKL------QLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAE 1003
Query: 283 IVDEKENVIKEVEGKRALLEIKEREHNQLVKLLELARENEATSLTERGILDLNLRNSLID 342
N+ +E E ++L ++K + + L E R E +R L+ R D
Sbjct: 1004 FT---TNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREE----KQRQELEKTRRKLEGD 1056
Query: 343 KQNYHDELSRKQREKERDFRNLRKME-----LLLKVSWDALRQTQALHQRLLLEMEAIPK 397
+ D+++ Q + L K E L +V +A ++ AL + LE +
Sbjct: 1057 STDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISEL 1116
Query: 398 DDSTLSERRRELHKEVEVAKRNLAQ--QKIISEMESKLVEQQLAEENKLLKEQENMKELV 455
+ SER + E KR+L + + + +E+E L +E + +EQE
Sbjct: 1117 QEDLESERAS--RNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQE------ 1168
Query: 456 VNLLRMTQIKIDEKEQKSKD--FLKAQQKYTNIVKEMKAKDLEIRIHKKKKCEIYRRLRE 513
VN+L+ T E+E K+ + + +QK++ V+E+ A+ LE K E
Sbjct: 1169 VNILKKTL----EEEAKTHEAQIQEMRQKHSQAVEEL-AEQLEQTKRVKANLE------- 1216
Query: 514 FAKLYDTIRNERNKFVNLLHKAHQKVNEIKERHK---MSLNELEILRNSAVSQERKLQNS 570
K T+ NER + N + Q + + + K L EL++ N +L +
Sbjct: 1217 --KAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADK 1274
Query: 571 MLK---HANNVT--------IRESMQNDVRKIVSKLQEMKEKKEAQLNNIDRLANTITMI 619
+ K +NVT + D + S+LQ+ +E + + L+ + +
Sbjct: 1275 VTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQV 1334
Query: 620 EEEMVQLRKRYEKAVQHRNESGVQLIEREEEICIFYEKINIQEKMKLNGEIEIHLLEEKI 679
E+E R++ E+ + ++ Q+ ++ +K+ E L++ +
Sbjct: 1335 EDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDL 1394
Query: 680 QFLKMKIAEKQRQICVTQKLLPAKRSLDADLAVLQIQFSQCTDRIKDLEK------QFVK 733
+ L + EK + KL K L +L L + +LEK Q +
Sbjct: 1395 EGLSQRHEEK---VAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLA 1451
Query: 734 PDGENRARFLPGKDLTEKEMIQKLDKLELQLAKKEEKLLEKDFIYEQVSRLTDRLCSKTQ 793
+ A++ +D E E +K K L LA+ E+ +E+ E++++
Sbjct: 1452 EEKTISAKYAEERDRAEAEAREKETK-ALSLARALEEAMEQKAELERLNKQFRTEMEDLM 1510
Query: 794 GCKQDTLLLAKKMNGYQRRIKNATEKMMALVAEL--------SMKQALTIELQ-KEVREK 844
K D ++ +R ++ E+M + EL K L + LQ + + +
Sbjct: 1511 SSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFE 1570
Query: 845 EDFIFTCNSRIEKGLPLNKEIEKEWLKVLRDEEMHALAIAEKSQEFLEADNRQLPNGVYT 904
D EK L +++ + ++ + + ++A+A + + LE D + L + +
Sbjct: 1571 RDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKK--LEMDLKDLEAHIDS 1628
Query: 905 TAEQRPNA 912
+ R A
Sbjct: 1629 ANKNRDEA 1636
Score = 90.9 bits (224), Expect = 5e-18
Identities = 179/908 (19%), Positives = 382/908 (42%), Gaps = 113/908 (12%)
Query: 67 LKAKYTLLHDAVMSTQESEVQLLQNAKRFTEQIQQQQFHLQQADNFPEAFSTEVSKMREQ 126
L+A+ + Q + ++ QN + EQ+++++ Q+ ++ K+ E+
Sbjct: 920 LEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEE 979
Query: 127 --LLKYQN---------------EYNAVKEREFHNQYRLNSLKEEKIIIVKEFEKITKPG 169
+L+ QN E+ E L LK + ++ + E+ +
Sbjct: 980 QIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRRE 1039
Query: 170 E-----MEKKMKILRESTEELRKEIMQKKLEIKNLREDLASKQKQLLKEQKELEELLG-- 222
E +EK + L + +L +I + + +I L+ LA K+++L +EE
Sbjct: 1040 EKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQK 1099
Query: 223 HQVVLKDEVAHHQTIPVQIGKEIEKITRKKVEMEKKKIVLEQE-VKT-LNDSLKK--VEN 278
+ + K Q +Q E E+ +R K E +K+ + E E +KT L D+L +
Sbjct: 1100 NMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQ 1159
Query: 279 KVSAIVDEKENVIK---EVEGKRALLEIKE--REHNQLVKLLELARENEATSLTERGILD 333
++ + +++ N++K E E K +I+E ++H+Q V+ ELA + E T +
Sbjct: 1160 ELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVE--ELAEQLEQTKRVK----- 1212
Query: 334 LNLRNSLIDKQNYHDELSRKQREKERDFRNLRKMELLLKVSWDA---LRQTQALHQRLLL 390
NL + +N EL+ ++++LL+ D+ ++ +A Q L +
Sbjct: 1213 ANLEKAKQTLENERGELA-------------NEVKVLLQGKGDSEHKRKKVEAQLQELQV 1259
Query: 391 EMEAIPKDDSTLSERRRELHKEVEVAKRNLAQQKIISEMESK---LVEQQLAEENKLLKE 447
+ + + L+++ +L E++ L+Q S +K +E QL + +LL+E
Sbjct: 1260 KFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQE 1319
Query: 448 QENMKELVVNLLRMTQIKIDEKEQKSKDFLKAQQKYTNIVKEMKAKDLEIRIHKKKKCEI 507
+ K + L+ + DEK + + ++ N+ K++ ++ KKK +
Sbjct: 1320 ENRQKLSLSTKLKQVE---DEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDS 1376
Query: 508 YRRLREFAKLYDTIRNERNKFVNLLHKAHQ-------KVNEIKERHKMSLNELEI----L 556
L + + ++ + K + L + H+ K+ + K R + L++L +
Sbjct: 1377 VGCL----ETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQ 1432
Query: 557 RNSAVSQERKLQ--NSMLKHANNVTIRESMQNDVRKIVSKLQEMK--------EKKEAQL 606
R SA + E+K + + +L ++ + + + D + ++ +E K E+ Q
Sbjct: 1433 RQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQK 1492
Query: 607 NNIDRLANTITMIEEEMVQLRKRYEKAVQHRNESGVQLIEREEEICIFYEKI--NIQEKM 664
++RL E+++ + K+V +S L ++ EE+ E++ +Q
Sbjct: 1493 AELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATE 1552
Query: 665 KLNGEIEIHLLEEKIQFLKMKIAEKQRQICVTQKLLPAKRSLDADLAVLQIQFSQCTDRI 724
+E++L K QF + ++ ++L+ R ++A+L + Q S
Sbjct: 1553 DAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAAR 1612
Query: 725 KDLEKQFVKPDGENRARFLPGKDLTEKEMIQKLDKLELQLAKKEEKLLEKDFIYEQVSRL 784
K LE D ++ + + E I++L KL+ Q+ +L + E++
Sbjct: 1613 KKLEM-----DLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQ 1667
Query: 785 TDRLCSKTQGCKQDTLLLAKKMNGYQRRIKNATEKMMAL---VAELSMKQALTIE----- 836
K + + + + L +++ +R + A ++ L +A S K AL +E
Sbjct: 1668 AKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRL 1727
Query: 837 ------LQKEVREKEDFIFTCNSRIEKGLPLNKEIEKEWLKVLRDEEMHALAIAEKSQEF 890
L++E+ E++ N R++K +I + L E HA E +++
Sbjct: 1728 EARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTD----LNLERSHAQK-NENARQQ 1782
Query: 891 LEADNRQL 898
LE N++L
Sbjct: 1783 LERQNKEL 1790
Score = 75.5 bits (184), Expect = 2e-13
Identities = 112/605 (18%), Positives = 250/605 (41%), Gaps = 63/605 (10%)
Query: 79 MSTQESEVQLLQNAKRFTEQIQQQQFHLQQADNFPEAFSTEVSKMREQL----------- 127
+ST+ +V+ +N+ F EQ+++++ + +V+ M++++
Sbjct: 1327 LSTKLKQVEDEKNS--FREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAE 1384
Query: 128 ---LKYQNEYNAVKEREFHNQYRLNSLKEEKIIIVKEFEKIT--------KPGEMEKKMK 176
K Q + + +R + L++ K + +E + + +EKK K
Sbjct: 1385 EVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQK 1444
Query: 177 ILRESTEELRKEIMQKKLEIKNLRE-DLASKQKQLLKEQKELEELLGHQVVLKDEVAHHQ 235
+ E K I K E ++ E + K+ + L + LEE + + L+ +
Sbjct: 1445 KFDQLLAE-EKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFR 1503
Query: 236 TIPVQIGKEIEKITRKKVEMEKKKIVLEQEVKTLNDSLKKVENKVSAIVDEKENVIKEVE 295
T + + + + E+EK K LEQ+V+ + L+++E+++ A D K + ++
Sbjct: 1504 TEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQ 1563
Query: 296 GKRALLEIK-----EREHNQLVKLLELARENEATSLTERGILDLNL--RNSL-IDKQNYH 347
+A E E+ + +L+ RE EA ER + + R L +D ++
Sbjct: 1564 AMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLE 1623
Query: 348 DELSRKQREKERDFRNLRKMELLLKVSWDALRQTQALHQRLLLEMEAIPKDDSTLSERRR 407
+ + ++ + LRK++ +K L T+A + +L + + K ++
Sbjct: 1624 AHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMI 1683
Query: 408 ELHKEVEVAKRNLAQQKIISEMESKLVEQQLAEENKLLKEQENMKELVVNLLRMTQIKID 467
+L +E+ A+R Q + + +L ++ K E + L + ++ +
Sbjct: 1684 QLQEELAAAERAKRQAQ---QERDELADEIANSSGKGALALEEKRRLEARIAQLEEEL-- 1738
Query: 468 EKEQKSKDFLKAQQKYTNIVKEMKAKDLEIRIHKKKKCEIYRRLREFAKLYDTIRNERNK 527
E+EQ + + + + K N+ + DL + +K E R+ E +NK
Sbjct: 1739 EEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLE----------RQNK 1788
Query: 528 FVNLLHKAHQKVNEIKERHKMSLNELEILRNSAVSQERKLQNSMLKHANNVTIRESMQND 587
+ + K + +K ++K S+ LE E +L N + R++
Sbjct: 1789 ELKV--KLQEMEGTVKSKYKASITALEA---KIAQLEEQLDNETKE-------RQAACKQ 1836
Query: 588 VRKIVSKLQEMKEKKEAQLNNIDRLANTITMIEEEMVQLRKRYEKAVQ--HRNESGVQLI 645
VR+ KL+++ + + + N ++ + + QL+++ E+A + R + + +
Sbjct: 1837 VRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKL 1896
Query: 646 EREEE 650
+RE E
Sbjct: 1897 QRELE 1901
Score = 41.2 bits (95), Expect = 0.005
Identities = 74/345 (21%), Positives = 152/345 (44%), Gaps = 43/345 (12%)
Query: 79 MSTQESEVQLLQNAKRFTEQIQQ-QQFHLQQADNFPEAFSTEVSKMREQLLKYQNEYNAV 137
M ++ E + K E I+Q ++ Q D E T S RE++L E
Sbjct: 1617 MDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRAS--REEILAQAKE---- 1670
Query: 138 KEREFHNQYRLNSLKEEKIIIVKEFEKITKPGEMEKKMKILRESTEELRKEIMQKKLEIK 197
N+ +L S++ E I + +E E+ + ++ +EL EI +
Sbjct: 1671 ------NEKKLKSMEAEMIQLQEEL------AAAERAKRQAQQERDELADEIANSSGKGA 1718
Query: 198 NLREDLASKQKQLLKEQKELEELLGHQVVLKDEV--AHHQTIPVQIGKEIEKITRKKVEM 255
E+ + ++ + ++ELEE G+ ++ D + A+ Q + +E+ +K E
Sbjct: 1719 LALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNEN 1778
Query: 256 EKKKIVLEQEVKTLNDSLKKVENKVSAIVDEKENVIKEVEGKRALLEIKEREHNQLVKLL 315
+++ LE++ K L L+++E V + + + I +E K A LE E+ N+ +
Sbjct: 1779 ARQQ--LERQNKELKVKLQEMEGTVKS---KYKASITALEAKIAQLE--EQLDNETKERQ 1831
Query: 316 ELARENEATSLTERGILDLNLRNSLIDKQNYHDELSRKQREKERDFRNLRKMELLLKVSW 375
++ TE+ + D+ L+ +D + + E + Q +K L++++ L+ +
Sbjct: 1832 AACKQ---VRRTEKKLKDVLLQ---VDDERRNAEQYKDQADKAS--TRLKQLKRQLEEAE 1883
Query: 376 DALRQTQALHQRLLLEMEAIPKDDSTLSERRRELHKEVEVAKRNL 420
+ ++ A ++L E+E D+T E +++EV K L
Sbjct: 1884 EEAQRANASRRKLQRELE-----DAT--ETADAMNREVSSLKNKL 1921
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 107 bits (268), Expect = 4e-23
Identities = 173/907 (19%), Positives = 397/907 (43%), Gaps = 116/907 (12%)
Query: 66 ALKAKYTLLHDAVMSTQ-------------ESEVQLLQNAKRFTEQIQQQQFHLQQADNF 112
+L+++ LH+ + S Q + E +LLQ AK E + Q HLQ A
Sbjct: 1310 SLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAK---ENLTAQVEHLQAAVVE 1366
Query: 113 PEAFSTEVSKMREQLLKYQNEYNAVKEREFHNQYRLNSLKEEKIIIVKEFEKITKP---- 168
A ++ + E L ++ E + R +L+E+ + V + + + +
Sbjct: 1367 ARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALL 1426
Query: 169 ----GEMEKKMKILRESTEELRKEIMQKKLEIKNLREDLASKQKQLLKEQKELEELLGHQ 224
E E++++ LR +EL K+ +K ++ L DL + +++ +Q++++EL +
Sbjct: 1427 TQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCR 1486
Query: 225 VVLKDEVAHHQTIPVQIGKEIEKITRKKVEMEKKKIVLEQEVKTLNDSLKKVENKVSAIV 284
VL+ Q ++ + E+I + + E ++ VLE ++ L + +E++ +
Sbjct: 1487 SVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQ 1546
Query: 285 DEKENVIKEVEGKRALLEIKEREH-----NQLVKLLELARENEATSLT------ERGILD 333
D K+ + V + LE++E H +L+K LE RE + +LT E +
Sbjct: 1547 DLKKQL---VTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQE 1603
Query: 334 LNLRNSLI-DKQNYHDELSRKQREKERDFRNLR-KMELLLKVSWDALRQTQALHQRLLLE 391
L ++S I D +++ L+R+ +E++++ ++ R ++E L + + + Q L+L+
Sbjct: 1604 LQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQ 1663
Query: 392 MEAIPKDDSTLSERRRELHKEVEVAKRNLAQQKIISEMESKLVEQQLAEENKLLKEQENM 451
E I + + + + L +++E K +L ++ + +L++++ E K Q
Sbjct: 1664 KERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGS 1723
Query: 452 KELVVNLLRMTQIKIDEKEQKSKDFLKAQQKYTNIVKEMKAKDLEIRIHKKKKCEIYRRL 511
E + +LR +KE++ ++ QQ++ + ++E+K LE ++ ++R++
Sbjct: 1724 LEHMKLILR-------DKEKE----VECQQEHIHELQELK-DQLEQQLQ-----GLHRKV 1766
Query: 512 REFAKLYDTIRNERNKFVNLLHKAHQKVNEIKERHKMSL-NELEILRNSAVSQERKLQNS 570
E + L ++R + + +L + Q+ E E + SL ++L+ + + ++++L
Sbjct: 1767 GETSLLL----SQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQEL--- 1819
Query: 571 MLKHANNVTIRESMQNDVRKIVSKLQEMKEKKEAQLNNIDRLANTITMIEEEMVQLRKRY 630
E++Q + ++ + + +KEK +A +E+ + L++R+
Sbjct: 1820 -----------EALQQEQQQAQGQEERVKEKADALQG----------ALEQAHMTLKERH 1858
Query: 631 EKAVQHRNESGVQLIEREEEICIFYEKINIQEKMKLNGEIEIHLLEEKIQFLKMKIAEKQ 690
+ H+ ++ ++E++ + G + LEE + L+ + E++
Sbjct: 1859 GELQDHKEQAR-----------------RLEEELAVEGR-RVQALEEVLGDLRAESREQE 1900
Query: 691 RQICVTQKLLPAKRSLDADLAVLQIQFS----QCTDRIKDLEKQFVKPDGENRARFLPGK 746
+ + Q+ A+++ + ++ +Q S Q + +D E + ++ + ++
Sbjct: 1901 KALLALQQQC-AEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAA 1959
Query: 747 DLTEKEMIQKLDKLELQLAKKEEKLLEKDFIYEQVSRLTDRLCSKTQGCKQDTLLLAKKM 806
+ + + L K L KE+ LLE+ + + T L + C+ + L + +
Sbjct: 1960 RARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEAL 2019
Query: 807 NGYQRRIKNATEKMMALVAELSMKQALTIELQKEVREKEDFIFTC------NSRIEKGLP 860
+ I++ + V +L A E + +E+E + + I++
Sbjct: 2020 RIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQN 2079
Query: 861 LNKEIEKEWLKVLRDEEMH-ALAIAEKSQEFLEADNRQLPNGVYTTAEQRPNAYIPEADA 919
L +E E+E ++ L L +A+K QE LE Q N + + + E
Sbjct: 2080 LGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSL 2139
Query: 920 TLPLPKP 926
L +P
Sbjct: 2140 KLDSLEP 2146
Score = 91.7 bits (226), Expect = 3e-18
Identities = 153/770 (19%), Positives = 350/770 (45%), Gaps = 92/770 (11%)
Query: 85 EVQLLQNAKRFTEQIQQQQFHLQQADNFPEAFSTEVSKMREQLLKYQNEYNAVKEREFHN 144
E +LLQ A+ E+++QQ L+Q E ++R ++ Q + ++ + ++
Sbjct: 464 ERELLQKAR---EELRQQLEVLEQ----------EAWRLRRVNVELQLQGDSAQGQKEEQ 510
Query: 145 QYRLNSLKEEKIIIVKEFEKITKP--GEMEKKMKILRESTEELRKEIMQKKLEIKNLRED 202
Q EE + V+E E++ + G K+ + L E LR+ + LE + LR++
Sbjct: 511 Q-------EELHLAVRERERLQEMLMGLEAKQSESLSELIT-LREALESSHLEGELLRQE 562
Query: 203 LASKQKQLLKEQKELEELLGHQVVLKDEVAHHQTIPVQIGKEIEKITRKKVEMEKKKIVL 262
L + ++ + EL + LK EVA + V++ E + KV + ++ + L
Sbjct: 563 QTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQL 622
Query: 263 EQEVKTLNDSLKKVENKVSAI-VDEKENVIKEVEGKR-ALLEIKEREHNQLVKLLELARE 320
E+E +++ ++ E +A+ VD + E E +R AL E QL K E E
Sbjct: 623 EEENQSVCSRMEAAEQARNALQVD-----LAEAEKRREALWEKNTHLEAQLQKAEEAGAE 677
Query: 321 NEATSLTERGILDLNLRNSLIDKQNYHDELSRKQREKERDFRNLRKMELLLK----VSWD 376
L +LR+ +K+ +LS + ++E L ++ K V
Sbjct: 678 -----------LQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLAR 726
Query: 377 ALRQTQALHQR---LLLEMEAIPKDDSTLSERRRELHKEVEVAKRNLAQQKIISEMESKL 433
A+++ +AL + L + ++A+ +D L+E+ + L E+ + +L + ++ ++ +
Sbjct: 727 AVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFE----AQQQNSV 782
Query: 434 VEQQLAEENKLLKEQENMKELVVNLLRMTQIKID--------EKEQKSKDFLKAQQKYTN 485
+E + ++ KE++ +R ++++D E++ ++ +A+Q+
Sbjct: 783 IEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKT 842
Query: 486 IVKEMK-AKDLEI-RIHKKKKCEIYRRLREFAKLYDTIRNERNKFVNLLHKAHQKVNEIK 543
+++ K A + E+ ++ +K + E +E AK +++ E+ + L + ++ I+
Sbjct: 843 ALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQ 902
Query: 544 ERHKMSLNELEILRNSAVSQERKLQNSMLKHANNVTIRESMQNDVRKIVSKLQEM----K 599
+ + + E SA+ Q + + V++ E++ +++ Q++ +
Sbjct: 903 AQREEERTQAE----SALCQMQ-----LETEKERVSLLETLLQTQKELADASQQLERLRQ 953
Query: 600 EKKEAQLNNIDRLANTITMIEEEMVQLRKRYEKAVQHRNESGVQLIEREEEICIFYEKIN 659
+ K +L + T ++E +L+ E A QHR++ +EE + +K++
Sbjct: 954 DMKVQKLKEQETTGILQTQLQEAQRELK---EAARQHRDDLAAL---QEESSSLLQDKMD 1007
Query: 660 IQEKMKLNGEIEIHLLEEKIQFLKMKIAEKQRQICVTQKLLPAKRSLDADLAVLQIQFSQ 719
+Q++++ + + ++ ++ + ++ ++ EK R+ TQ+ ++ L+ + A L + +
Sbjct: 1008 LQKQVE-DLKSQLVAQDDSQRLVEQEVQEKLRE---TQEYNRIQKELEREKASLTLSLME 1063
Query: 720 CTDRIKDL-EKQFVKPDGENRARFLPGKDLTEKEMIQKLDKLELQLAKKEEKLLEKDFIY 778
R+ L E ++ + R +D+ E + QK +++L ++E K E DF+
Sbjct: 1064 KEQRLLVLQEADSIRQQELSALR----QDMQEAQGEQKELSAQMELLRQEVKEKEADFLA 1119
Query: 779 EQVSRLTDRLCSKTQGCKQDTLLLAK--KMNGYQRRIKNATEKMMALVAE 826
++ L + S + L A+ K Q R+++ ++ AL AE
Sbjct: 1120 QEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAE 1169
Score = 81.3 bits (199), Expect = 4e-15
Identities = 132/743 (17%), Positives = 304/743 (40%), Gaps = 94/743 (12%)
Query: 82 QESEVQLLQ-NAKRFTEQIQQQQFHLQQADNFPEAFSTEVSKMREQLLKYQNEYNAVKER 140
Q++ ++LL + K+ +++ QQ +Q+ + ++E+ K + ++E
Sbjct: 1454 QKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIREL 1513
Query: 141 EFHNQYRLNSLKEEKIIIVKEFEKI-TKPGEMEK--------------------KMKILR 179
E + + N L+ + + + K+ + I ++ G+++ KM+ +
Sbjct: 1514 EKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQ 1573
Query: 180 ESTEELRKEIMQKKLEIKNLREDLASKQKQLLKEQKELEELLGHQVVLKDEVAHHQTIPV 239
+ +EL + +++ + +L DL + ++L + ++ +L H VL E+
Sbjct: 1574 KLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVK 1633
Query: 240 QIGKEIEKITRKKVEMEKKKIVLEQEVKTLNDSLKKVENKVSAIVDEKENVIKEVEGKRA 299
++IE++ R+K L Q+++ + L + ++ + D++ K +E
Sbjct: 1634 SQREQIEELQRQKEH-------LTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLE 1686
Query: 300 LLEIKEREH-----NQLVKLLELARENEATSLTERGILDLNLRNSLIDKQNYHDELSRKQ 354
+++ RE Q + E A E + S +RG L+ H +L +
Sbjct: 1687 QIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLE-------------HMKLILRD 1733
Query: 355 REKERDFRNLRKMELLLKVSWDALRQTQALHQRLLLEMEAIPKDDSTLSERRRELHKEVE 414
+EKE ++ + + + Q L +L +++ + + S + +E+
Sbjct: 1734 KEKE------------VECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIV 1781
Query: 415 VAKRNLAQQKIISEMESKLVEQQLAEENKLLKEQENMKELVVNLLRMTQIKIDEKEQKSK 474
V ++ L + + E++ + ++ QL E + L +++ E + + Q + +E+ ++
Sbjct: 1782 VLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQ-EERVKEKA 1840
Query: 475 DFLKAQQKYTNIVKEMKAKDLEIRIHKKKKCEIY-------RRLREFAKLYDTIRNERNK 527
D L+ + ++ +K + E++ HK++ + RR++ ++ +R E +
Sbjct: 1841 DALQGALEQAHMT--LKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESRE 1898
Query: 528 FVNLLHKAHQKVNEIKERHKMSLNELE--ILRNSAVSQERKLQNSMLKHANNVTIRESMQ 585
L Q+ E + H++ L+ L+ AV +ER + L+ + + +
Sbjct: 1899 QEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSS--RHQE 1956
Query: 586 NDVRKIVSKLQEMKEKKEAQLNNIDR----LANTITMIEEEMVQLRKRYEKAVQHRNESG 641
R LQE K A L ++ A +E L+ + H +
Sbjct: 1957 EAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLE 2016
Query: 642 VQLIEREEEI----CIFYEKINIQEKMKLNGEIEIHLLEEKIQFLKMKIAEKQRQICVTQ 697
L +E EI + E + ++ + E+ +E+ Q L+ +A++ ++ + +
Sbjct: 2017 EALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQE 2076
Query: 698 KLLPAK-------RSLDADLAVLQIQFSQCTDRIKDLEKQFVKPDGENRARFLPGKDLTE 750
K + R L + LQ+ +Q I +L + N LP T
Sbjct: 2077 KQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELR----ETQQRNNLEALPHSHKTS 2132
Query: 751 --KEMIQKLDKLELQLAKKEEKL 771
+E KLD LE +L ++ E+L
Sbjct: 2133 PMEEQSLKLDSLEPRLQRELERL 2155
Score = 80.1 bits (196), Expect = 9e-15
Identities = 178/834 (21%), Positives = 350/834 (41%), Gaps = 125/834 (14%)
Query: 179 RESTEELRKEI--MQKKLEIKNLREDLASKQKQLLKEQKELEELLGHQVVLKDEVAHHQT 236
R++ ++LR+++ Q+ + + + D ++ + L+++ L++L G + L + Q
Sbjct: 399 RQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQR--LQKLTGERDTLAGQTVDLQG 456
Query: 237 IPVQIGKEIEKITRKKVEMEKKKIVLEQEVKTLNDSLKKVENKVSAIVDEKENVIKEVEG 296
+ KE E + + + E+ ++ VLEQE L +++ + + +KE +E+
Sbjct: 457 EVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELH- 515
Query: 297 KRALLEIKEREHNQLVKLLELARENEATS--LTERGILD-LNLRNSLIDKQNYH------ 347
L ++ERE Q + + A+++E+ S +T R L+ +L L+ ++
Sbjct: 516 ----LAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALA 571
Query: 348 ------DELSRKQREKERDFRNLRKMELLLKVSWDALR-----------QTQALHQRLLL 390
ELS + + + +LR + L +AL Q + +Q +
Sbjct: 572 RAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCS 631
Query: 391 EMEAIPKDDSTL------SERRRE------LHKEVEVAKRNLAQQKIISEMESKLVEQQL 438
MEA + + L +E+RRE H E ++ K A ++ +++ ++++
Sbjct: 632 RMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRD--IQEEK 689
Query: 439 AEENKLLKEQENMKELVVNLLRMTQIKIDEKEQKSKDFLKAQQKYTNIVKEMKAKDLEIR 498
E K L E + +E L E +++ + +A Q+ +V+E A ++ ++
Sbjct: 690 EEIQKKLSESRHQQEAATTQLEQLH---QEAKRQEEVLARAVQEKEALVREKAALEVRLQ 746
Query: 499 IHKKKKCEIYRRLREFAKLYDTIRN------ERNKFVNL----LHKAHQKVNEIKE--RH 546
++ + ++ +L+ + + + + ++N + + L Q V + KE +
Sbjct: 747 AVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQG 806
Query: 547 KMSLNELEI-LRNSAVSQERKLQNSMLKHA--NNVTIRESMQNDVRKIVSKLQEMKEKKE 603
++ +LE+ S QER L A T E + K V++L+E EK+
Sbjct: 807 EVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKER 866
Query: 604 AQLNNIDRLANTITMIEEEMVQLRKRYE------KAVQ-HRNESGVQL--------IERE 648
+ + LA + +E E ++L R + +A+Q R E Q +E E
Sbjct: 867 SW--HQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETE 924
Query: 649 EEICIFYEKINIQEKMKLNGEIEIHLLEEKIQFLKMKIAEK----QRQICVTQK-LLPAK 703
+E E + +K + ++ L + ++ K+K E Q Q+ Q+ L A
Sbjct: 925 KERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAA 984
Query: 704 RSLDADLAVLQIQFSQCTD-------RIKDLEKQFVKPDGENRARFLPGKDLTEKEMIQK 756
R DLA LQ + S +++DL+ Q V D R L E+E+ +K
Sbjct: 985 RQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQR--------LVEQEVQEK 1036
Query: 757 LDKLELQLAKKEEKLLEKDFIYEQVSRLTDRLCSKTQGCKQDTLLLAKKMNGYQRRIKNA 816
L + + E ++K+ E+ S LT L K +Q L+L + + Q+ +
Sbjct: 1037 LRETQ------EYNRIQKELEREKAS-LTLSLMEK----EQRLLVLQEADSIRQQELSAL 1085
Query: 817 TEKMMALVAELSMKQALTIELQKEVREKEDFIFTCNSRIEKGLPLNKEIEKEWLKVLRDE 876
+ M E A L++EV+EKE +++ + L + E++ L +
Sbjct: 1086 RQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQ 1145
Query: 877 EMHALAIAEKSQEFLEADNRQLPNGVYTTAEQRPNAYIPEADATLPLPKPYGAL 930
E A A + Q L + QL AEQ+P +A A L Y AL
Sbjct: 1146 E----AKAAQLQLRLRSTESQLE---ALAAEQQPG---NQAQAQAQLASLYSAL 1189
Score = 48.5 bits (114), Expect = 3e-05
Identities = 177/874 (20%), Positives = 341/874 (39%), Gaps = 138/874 (15%)
Query: 114 EAFSTEVSKMREQLLKYQNEYNAVKEREFHNQYRLNSLKEEKIIIVKEFEKITKPGEMEK 173
E S ++ M+ Q L+ E + ++ + + S ++ K + + T +++
Sbjct: 2 ETRSPGLNNMKPQSLQLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQA 61
Query: 174 KMKILRESTEELRKEIMQ---------KKLEIKNLREDLASKQKQLLKEQKELEELLGHQ 224
K+ R +EL K + + +E NL E L +L +EQ+ E L
Sbjct: 62 KVLQYRSWCQELEKRLEATGGPIPQRWENVEEPNLDELLV----RLEEEQQRCESLAEVN 117
Query: 225 VVLKDEVAHHQTIPVQIGKEIEKIT----RKKVEMEKKKIVLEQEVKTLNDSLKKVENKV 280
L+ + + + +++EK+T R + E+ +K+ + E + LK ++
Sbjct: 118 TQLRLHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRL 177
Query: 281 SAIVDEKENVIKEVEGKRALLEIKEREHNQLVKL---------------LELARENEATS 325
++ E V +R LE+K L++L L L ++
Sbjct: 178 LSLWREV------VTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSRE 231
Query: 326 LTERGILDLNLRNSLIDKQNYHDELSRKQREKERDFRNLR------KMELLLKVSWDALR 379
G +D L+ EL ++ E+ ++ L+ K EL +V+ +
Sbjct: 232 PNGSGRMDGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSAL 291
Query: 380 QTQALHQRLLLE--MEAIPKDDSTLSERRRELHKEVEVAKRNLAQQKIISEMESKLVEQQ 437
TQ+ Q E ++A+ + L EL + RN ++K+ + K + Q
Sbjct: 292 LTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQV 351
Query: 438 LAEENKLLKE---QENMKEL---------------VVNLLRMTQIKIDEKEQKSKDFLKA 479
+ EE + + EN EL + L+R + + Q + L
Sbjct: 352 MVEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAG 411
Query: 480 QQKYTNIVK------EMKAKDLEIRIHK--KKKCEIYRRLREFAKLYDTIRNERNKFVNL 531
Q+ N+++ E + K L R+ K ++ + + + D++ ER L
Sbjct: 412 CQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKER----EL 467
Query: 532 LHKAHQKVNEIKERHKMSLNELEILRNSAVSQERKLQNSMLKHANNVTIRESMQNDVRKI 591
L KA +++ R ++ + E E R V+ E +LQ + +E Q ++
Sbjct: 468 LQKAREEL-----RQQLEVLEQEAWRLRRVNVELQLQGDSAQGQ-----KEEQQEELHLA 517
Query: 592 V---SKLQEMKEKKEAQLNNIDRLANTITMIEEEMVQLRKRYEKAVQHRNESGVQLIERE 648
V +LQEM EA+ + + L+ IT + E + E Q + E L E
Sbjct: 518 VRERERLQEMLMGLEAKQS--ESLSELIT-LREALESSHLEGELLRQEQTEVTAALARAE 574
Query: 649 EEICIFYEKINIQEKMKLN---GEIEIHLLEEKIQFLK-------MKIAEKQRQICVTQK 698
+ I N + + +++ L E + K +++ E+ + +C +
Sbjct: 575 QSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRME 634
Query: 699 LL-PAKRSLDADLAVLQIQFSQCTDRIKDLEKQFVKPDGENRARFLPGKDL-TEKEMIQK 756
A+ +L DLA + + ++ LE Q K + +D+ EKE IQK
Sbjct: 635 AAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQK 694
Query: 757 ---------------LDKLELQLAKKEEKLL-----EKDFIYEQVSRLTDRLCSKTQGCK 796
L++L Q AK++E++L EK+ + + + L RL Q +
Sbjct: 695 KLSESRHQQEAATTQLEQLH-QEAKRQEEVLARAVQEKEALVREKAALEVRL----QAVE 749
Query: 797 QDTLLLAKKMNGYQRRIKNATEKMMALVAELSMKQALTIELQKEVREKEDFIFTCNSRIE 856
+D LA+++ G + +A E + + + E + +Q IE+ K E + T +
Sbjct: 750 RDRQDLAEQLQG----LSSAKELLESSLFE-AQQQNSVIEVTKGQLEVQIQTVTQAKEVI 804
Query: 857 KG----LPLNKEIEKEWLKVLRDEEMHALAIAEK 886
+G L L + E+ + RD LA AE+
Sbjct: 805 QGEVRCLKLELDTERSQAEQERDAAARQLAQAEQ 838
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 107 bits (267), Expect = 5e-23
Identities = 196/841 (23%), Positives = 364/841 (43%), Gaps = 112/841 (13%)
Query: 118 TEVSKMREQLL----KYQNEYNAVKEREFHNQYRLNSLKEEKIIIVKEFEKITKPGE--- 170
TE+S +++QL K QN+ + E+E + S +EK+ +K+F++ K +
Sbjct: 1505 TEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSAL 1564
Query: 171 --MEKKMKILRESTEELRKEI---MQKKLEIKNLREDLASKQKQLLKEQKELEELLGHQV 225
+E KM L +E ++EI +++K E+K ++E L ++ QL + KE+ +
Sbjct: 1565 QSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQ 1624
Query: 226 VLKDEVAHHQTIPVQIGKEIEKITRKKVEMEKKKIVLEQEVKTLNDSLKKVENKVSAIVD 285
K+ T + +++ +I K + E +K+ LE ++T N L ++ ++ ++
Sbjct: 1625 E-KEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLEN-IETENIRLTQILHEN---LE 1679
Query: 286 EKENVIKEVEGKRALLEIKEREHNQLVKLLELARENEATSLTERGILDLNLRNSLIDKQN 345
E +V KE + R++ E + E +QL + L + E I+ ++L+ + Q
Sbjct: 1680 EMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLK----EHQE 1735
Query: 346 YHDELSRKQREKERDFRNLRKMELLLKVSWDALRQTQALHQRLLLEMEAIPKDDSTLSER 405
D+L EK + N++K L+ S DAL+ D + E
Sbjct: 1736 TIDKLRGIVSEKTNEISNMQKD---LEHSNDALKA-----------------QDLKIQEE 1775
Query: 406 RRELHKEVEVAKRNLAQQK-IISEMESKLVEQQLAEENKLLKEQENMKELVVNLLRMTQI 464
R H ++ + + + + I+SE KL Q EN K QE ++EL N ++ +
Sbjct: 1776 LRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITL 1835
Query: 465 KIDEKEQKSKDFLKAQQKYTNIVKEMKAKDLEIRIHKKKKCEIYRRLREFAKLYDTIRNE 524
K D E + K Q K K++K + L + + + + ++L E + ++ E
Sbjct: 1836 KKDVNETQKKVSEMEQLK-----KQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKE 1890
Query: 525 RNKFVNLLHKAHQKVNEIKERHKMSLNELEILRNSAVSQERKLQNSMLK-HANNV-TIRE 582
R+ L + + + +++ K SL E + R+ + QE K + K H V +RE
Sbjct: 1891 RDN----LRRVEETLKLERDQLKESLQETK-ARDLEIQQELKTARMLSKEHKETVDKLRE 1945
Query: 583 SMQ------NDVRK--------IVSKLQEMKEKKEAQLNNIDRLANTITMIEEEMVQLRK 628
+ +D++K + K+QE+ +KKE QL + N EM QL+K
Sbjct: 1946 KISEKTIQISDIQKDLDKSKDELQKKIQEL-QKKELQLLRVKEDVNMSHKKINEMEQLKK 2004
Query: 629 RYEK---AVQHRNESGVQLIEREEEICIFYEKINI--QEKMKLNGEIEIHLLEEKIQFLK 683
++E ++Q QL ++ E E+I I +E+ +L I+ L E+ QF+
Sbjct: 2005 QFEAQNLSMQSVRMDNFQLTKKLHE---SLEEIRIVAKERDELR-RIKESLKMERDQFIA 2060
Query: 684 --MKIAEKQRQICVTQKLLPAKRSLDADLAVLQIQFSQCTDRIKDLEKQFVKPDGENRAR 741
++ + RQ ++ P KR L L + RIK+L K++ + D
Sbjct: 2061 TLREMIARDRQ---NHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECL 2117
Query: 742 FLPGKDLTEKEMIQKLDKLELQLAKKEEKLLEKDFIYEQVSRLTDRLCSKTQGCKQDTLL 801
DL ++ QK EL + K L Y Q + ++L + Q C +
Sbjct: 2118 NRLSLDLEKEIEFQK----ELSMRVKANLSLP----YLQTKHI-EKLFTANQRCSMEFHR 2168
Query: 802 LAKKMNGYQRRIKNATEKMMALVAELSMKQALTIELQKEVREK-EDFIFTCN--SRIEKG 858
+ KK+ + E+ + + M +E QKE+ K + C+ SR +
Sbjct: 2169 IMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRD 2228
Query: 859 LPLNKEIEKEWLKVLRD-----------EEMHALAIAEKSQEFLEA------DNRQLPNG 901
L LN+ ++ ++L+D E L+ ++ +FLE D +L NG
Sbjct: 2229 LKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNG 2288
Query: 902 V 902
+
Sbjct: 2289 I 2289
Score = 105 bits (261), Expect = 3e-22
Identities = 185/904 (20%), Positives = 386/904 (42%), Gaps = 73/904 (8%)
Query: 68 KAKYTLLHDAVMSTQESEVQLLQNAKRFTEQIQQQQFHLQQADNFPEAFSTEVSKMREQL 127
K + L + +E +L K+ IQ Q L+ E+ ++
Sbjct: 638 KRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEI 697
Query: 128 LKYQNEYNAVKEREF----HNQYRLNSLKEEKIIIVKEFEKITKPGEMEKKMKILRESTE 183
K + + ++ + ++ L++E V+E E + + + ++K L E
Sbjct: 698 TKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVE 757
Query: 184 ELRKEIMQKKLEIKNLREDLASKQKQLLKEQKELEELLGHQVVLKDEVAHHQTIPVQIGK 243
LRKEI K E+ + + +++ ++ ++ LL KD++A Q+ +
Sbjct: 758 RLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQ 817
Query: 244 EIEKITRKKVEMEKK-KIVLE------QEVKTLNDSLKKVENKVSAIVDEKENVIKEVEG 296
E + ++ E+K K+VLE QE+ L+ +K ++ + A+ E +E++
Sbjct: 818 EFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQE 877
Query: 297 KRALLEIKEREHNQLVKLLELARENEATSLTERGILDLNLRNSLIDKQNY---HDELSRK 353
K ++ + E QL + LE T E+ ++ L+ +L + + D+L +
Sbjct: 878 KTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQL 937
Query: 354 QREKERDFRNLRK-MELLLKVSWDALRQTQALHQRLLLEMEAIPKDDSTLSER-RRELHK 411
Q + + L+ + + ++ D Q + + L E I S +SE R LH
Sbjct: 938 QESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHM 997
Query: 412 EVEVAK-RNLAQQKII-----SEMESKLVEQQLAE--ENKLLKEQENMKELVV---NLLR 460
E + ++ QQK++ ++E+K + A+ +N+++++Q + L+ L +
Sbjct: 998 EENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQ 1057
Query: 461 MTQIKIDEKEQKSKDF-------LKAQQKYTNIVKEMKAKDLEIRIHK----KKKCEIYR 509
M + I EKEQ D ++ Q++ + E+K + + K KK+ E+ R
Sbjct: 1058 MLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSR 1117
Query: 510 RLREFAKLYDTIRNERNKFVNLLHKAHQKVNEIKERHKM--SLNELEILRNSAVSQERKL 567
A++ + + + K L K Q +N +E +M +NE+E L+N ++E L
Sbjct: 1118 TCDRLAEVEEKL---KEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTL 1174
Query: 568 QNSMLKHANNVTIRESMQNDVRKIVSKLQEMKEKKEAQLNNIDRLANTITMIEEEMVQLR 627
++ + +V+ I + + +KE +++ D L I IE +Q +
Sbjct: 1175 EHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTK 1234
Query: 628 KRYEKAVQHRNESGVQLIEREEEICIFYEK----INIQEKMKLNGEI--EIHLLEEKIQF 681
+ + A H E + E + EK IN Q+ K + ++ EI +L E+ +
Sbjct: 1235 EELKIAHIHLKEHQETIDELRRSVS---EKTAQIINTQDLEKSHTKLQEEIPVLHEEQEL 1291
Query: 682 LK--MKIAEKQRQICVTQKLLPAKRSLDA-DLAVLQIQFSQCTDRIKDLEKQFVKPDGEN 738
L +++E Q + + L + D+ LA ++++ + ++ ++ +++ +K +
Sbjct: 1292 LPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEE-IKSLTKE 1350
Query: 739 RARFLPGKDLTEKEMIQKLDKLELQLAKKEE--KLLEKDFIYEQVSRLTDRLCSKTQGCK 796
R K+ E + Q + + LAK +E E+ ++ T ++ S+ + K
Sbjct: 1351 RDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFK 1410
Query: 797 -QDTLLL--AKKMNGYQRRIKNATEKMMALVAELSMKQALTIELQKEVREKEDFIFTCNS 853
+D+ LL +M G +R++ + ++M ++ E Q L LQ E + ++ I
Sbjct: 1411 PKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENI---KE 1467
Query: 854 RIEKGLPLNKEIEKEWLKVLRDEEM---HALAIAEKSQEF------LEADNRQLPNGVYT 904
+ K L +E++ + EE + ++EK E LEA N +L N +
Sbjct: 1468 IVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQE 1527
Query: 905 TAEQ 908
E+
Sbjct: 1528 IYEK 1531
Score = 94.0 bits (232), Expect = 6e-19
Identities = 185/908 (20%), Positives = 382/908 (42%), Gaps = 149/908 (16%)
Query: 97 EQIQQQQFHLQQADNFPEAFSTEVSKMREQLLKYQ--NEYNAVKEREFHNQYRLNSLKEE 154
E+++ + D F EA + K +E L ++ N N VK E +NQ N L +
Sbjct: 522 EEMELKLKEKNDLDEF-EALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSK 580
Query: 155 KIIIVKEFEKITKPGEMEKKMKILRESTEELRKEIMQKKLEI---KNLREDLASKQKQLL 211
++ ++ ++I K E K+ E ++ ++ I K +++ L + L
Sbjct: 581 VELLREKEDQIKKLQEYIDSQKL-----ENIKMDLSYSLESIEDPKQMKQTLFDAETVAL 635
Query: 212 KEQKELEELLGHQVVLKDEVAHHQTIPVQIGKEIEKITRKKVEMEKKKIVLEQEVKTLND 271
++E L + LK+++ T Q+ +I+ + +K ++ LE+E+++ +
Sbjct: 636 DAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFN 695
Query: 272 SLKK----VENKV-----------SAIVDEKENVIKEVEGKRALLE--IKEREHNQLVKL 314
+ K ++ KV I D ++ + KEVE AL E I E L
Sbjct: 696 EITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSE 755
Query: 315 LELARENEATSLTERGILDL---NLRNSLIDKQN-----------YHDELSRKQ---REK 357
+E R+ E I+ L + ++ K++ D+L+ Q +
Sbjct: 756 VERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKST 815
Query: 358 ERDFRNLRKMELLLKVSWD-ALRQTQALHQRLLLEMEAIPKDDSTLSERRREL-HKEVEV 415
+++F+N + + + + + L + + ++Q ++ + K DS+L + EL +K E+
Sbjct: 816 DQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQEL 875
Query: 416 AKRNLAQQKIISEMESKLVEQQLAEENKLLKEQENMKELVVNLLR--------MTQIKID 467
++ Q+ ++EME +++QL + L+ E K L+ L+ +TQ K D
Sbjct: 876 QEKTREVQERLNEMEQ--LKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDD 933
Query: 468 EKE-----QKSKDFLKA------------QQKYTNIVKEMKAKDLEIRIHKKK-KCEIYR 509
K+ Q +D LK+ Q++ N ++ +K I K K E+ R
Sbjct: 934 LKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSR 993
Query: 510 RLREFAKLYDTIRNERNKFVNLLHK------------AHQKVNEIKERHK------MSLN 551
L +T + K V + K A K NEI E+ + N
Sbjct: 994 NLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKN 1053
Query: 552 ELEILRNSAVSQERKLQNSMLKHANNVTIRESMQNDVRKIVSKLQEMKEKKEAQLNNIDR 611
EL+ + S ++++ +L+ + N+ + Q ++R + +L++ +E + N+ +
Sbjct: 1054 ELQQMLESVIAEKEQLKTDL---KENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIK 1110
Query: 612 LANTITMIEEEMVQLRKRYEKAVQHRNESGVQLIEREEEICIFYEKINIQEKMK---LNG 668
++ + + ++ ++ ++ Q E QL+ +EE+ +KIN E +K N
Sbjct: 1111 KEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNK 1170
Query: 669 EIEIHLLEEKIQFLKMKIAEKQRQI-CVTQKLLPAK-----------------RSLDA-- 708
E+ + +E + L K+ E ++ +T++ K R ++A
Sbjct: 1171 ELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATG 1230
Query: 709 -----DLAVLQIQFSQCTDRIKDLEKQFVKPDGENRARFLPGKDLTEKEMIQKLDKLELQ 763
+L + I + + I +L + E A+ + +DL + KL + E+
Sbjct: 1231 LQTKEELKIAHIHLKEHQETIDELRRSV----SEKTAQIINTQDLEKSH--TKLQE-EIP 1283
Query: 764 LAKKEEKLL-------EKDFIYEQVSRLTDRLCSKTQ----GCKQDTLLLAKKMNGYQRR 812
+ +E++LL E ++ LT++ +K + + L L +K Q
Sbjct: 1284 VLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEE 1343
Query: 813 IKNATEKMMALVAELSMKQALTI---ELQKEVREKEDFIFTCNSRIEKGLPLNKEIEKEW 869
IK+ T++ L ++K+AL + +L++ +RE I S+ E+ L + KE + E
Sbjct: 1344 IKSLTKERDNL---KTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNM-KEKDNET 1399
Query: 870 LKVLRDEE 877
K++ + E
Sbjct: 1400 TKIVSEME 1407
Score = 91.7 bits (226), Expect = 3e-18
Identities = 151/814 (18%), Positives = 347/814 (42%), Gaps = 118/814 (14%)
Query: 64 MAALKAKYTLLHDAVMSTQESEVQLLQNAKRFTEQIQQQQFHLQQADNFPEAFSTEVSKM 123
+ ALK + + + + L ++ EQ++ + LQ + + ++ +
Sbjct: 861 LGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQT 920
Query: 124 REQLLKYQNEYNAVKE-------------REFHNQYRLN------------SLKEEKIII 158
E++ E + +K+ + H+ +N SLK+ + I
Sbjct: 921 LEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETI 980
Query: 159 VKEFEKITK-----------PGE-----------MEKKMKILRESTEELRKEI------- 189
KI++ GE ++KK + ++T+ L ++
Sbjct: 981 NTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIE 1040
Query: 190 --------MQKKLEIKNLREDLASKQKQL---LKEQKELE-------ELLGHQVVLKDE- 230
+Q+K E++ + E + ++++QL LKE E+ LLG ++ + E
Sbjct: 1041 QQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEI 1100
Query: 231 VAHHQTIPVQIGKEIEKITRKKVEMEKKKIVLEQEVKTLNDSLKKVENKVSAI---VDEK 287
VA + ++ E+ + + E+E+K Q+++ L V+ ++S + ++E
Sbjct: 1101 VAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEI 1160
Query: 288 ENVIKEVEGKRALLEIKEREHNQLVKLLELARENEATSLTERGILDLNLRNSLIDKQNY- 346
EN+ E++ K LE E E +L + L E + ER +L L+ S ++++
Sbjct: 1161 ENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLK-ELQKSFETERDHL 1219
Query: 347 -----HDELSRKQREKERDFRNLRKMELLLKVSWDALRQTQALHQRLLLEMEAIPKDDST 401
E + Q ++E ++ E + + D LR++ + ++ + + K +
Sbjct: 1220 RGYIREIEATGLQTKEELKIAHIHLKE--HQETIDELRRSVSEKTAQIINTQDLEKSHTK 1277
Query: 402 LSERRRELHKEVEVAKRNLAQQKIISEMESKLVEQQLAEENKLLKEQENMKELVVNLLRM 461
L E LH+E E+ L K +SE + + E +L E K+ + + M
Sbjct: 1278 LQEEIPVLHEEQEL----LPNVKEVSETQETMNELELLTEQSTTKDSTTLAR-----IEM 1328
Query: 462 TQIKIDEKEQKSKDFLKAQQKYTNIVKEMKAKDLEIRIHKKKKCEIYRRLREFAKLYDTI 521
+++++EK Q+S++ +K+ K + +K +K + LE+ K ++ +RE
Sbjct: 1329 ERLRLNEKFQESQEEIKSLTKERDNLKTIK-EALEV-----KHDQLKEHIRETLAKIQES 1382
Query: 522 RNERNKFVNLLHKAHQKVNEIKERHKMSLNELEILR--NSAVSQERKLQNSMLKHANNVT 579
++++ + +N+ K ++ + E + + +LR + ++LQ S + +
Sbjct: 1383 QSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAK 1442
Query: 580 IRESMQNDVRKIVSKLQEMKEKKEAQL-NNIDRLANTITMIEEEMVQLRKRYEKAVQHRN 638
++ +Q +LQE+ + + QL NI + EEE+ ++ + N
Sbjct: 1443 EKDDLQ--------RLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETIN 1494
Query: 639 ESGVQLIEREEEICIFYEKINIQEKMKLNGEIEIHLLEEKIQFLKMKIAEKQRQICVTQK 698
E V L E+E EI +++ KL +I+ + E++ QF +I+E Q ++ ++
Sbjct: 1495 ELRVNLSEKETEISTIQKQLEAIND-KLQNKIQ-EIYEKEEQFNIKQISEVQEKVNELKQ 1552
Query: 699 LLPAKRSLDADLAVLQIQFSQCTDRIKDLEK--QFVKPDGENRARFLPGKDLTEKEMIQK 756
+++ D+ L ++ + + T+R+++ ++ Q + + E R + ++ +
Sbjct: 1553 FKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKEN 1612
Query: 757 LDKLELQLAKKEEKLLEKDFI-YEQVSRLTDRLC 789
++ ++ + +EK E F+ V+ +++C
Sbjct: 1613 TKEIVAKMKESQEK--EYQFLKMTAVNETQEKMC 1644
Score = 73.2 bits (178), Expect = 1e-12
Identities = 160/834 (19%), Positives = 340/834 (40%), Gaps = 104/834 (12%)
Query: 74 LHDAVMSTQESEVQLLQNAKRFTEQIQQQQFHLQQADNFPEAFSTEVSKMREQLLKYQNE 133
+ D ++ + E++ L A++ E +++ + +++ DN T + R+QL + E
Sbjct: 1856 IKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEET-LKLERDQLKESLQE 1914
Query: 134 YNAVKEREFHNQYRLNSLKEEKIIIVKEFEKITKPGEMEKKMKILRESTEELRKEIMQKK 193
K R+ Q L + + ++ KE +E+ ++LR++I +K
Sbjct: 1915 ---TKARDLEIQQELKTAR----MLSKEH----------------KETVDKLREKISEKT 1951
Query: 194 LEIKNLREDLASKQKQLLKEQKELEELLGHQVVLKDEVAHHQTIPVQIGKEIEKITRKKV 253
++I ++++DL + +L K+ +EL++ + +K++V K+I ++ + K
Sbjct: 1952 IQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSH-------KKINEMEQLKK 2004
Query: 254 EMEKKKIVLEQEVKTLNDSLKKVENKVSAIVDEKENVIKEVEGKRALLEIKEREHNQLV- 312
+ E + + + Q V+ N L K K+ ++E V KE + R + E + E +Q +
Sbjct: 2005 QFEAQNLSM-QSVRMDNFQLTK---KLHESLEEIRIVAKERDELRRIKESLKMERDQFIA 2060
Query: 313 ---KLLELARENEATSLTERGILD--LNLRNSLIDKQNYHDELSRKQREKERDFRNLRKM 367
+++ R+N +R + D +L SL +K + EL ++ E + + L ++
Sbjct: 2061 TLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRL 2120
Query: 368 ELLLKVSWDALRQTQALHQRLL----LEMEAIPKDDSTLSERRRELHKEVEVAKRNLAQQ 423
L L+ + ++ + L L+ + I K + E H R + +
Sbjct: 2121 SLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFH-------RIMKKL 2173
Query: 424 KIISEMESKLVEQQLAEENK----LLKEQENMKELVVNLLRMTQIKIDEKEQKSKDFLKA 479
K + +K+ E+Q NK + E E KEL++ + + Q D ++ +D LK
Sbjct: 2174 KYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQ-DCDVPSRELRD-LKL 2231
Query: 480 QQK----YTNIVKEMKAKDL-EIRIHKKKKCEIYRRLREFAKLYDTIRNERNKFVNLLHK 534
Q I+K+ + I+ ++ + + +F + + R + K N + K
Sbjct: 2232 NQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQK 2291
Query: 535 AHQKVNEIKERHKMSLNELEILRNSAVSQERKLQNSMLKHANNVTIRESMQNDVRKIVSK 594
+ ++ ++ + + I+ S +ER + TI + + D
Sbjct: 2292 ENDRICQVNNFFNNRI--IAIMNESTEFEER-----------SATISKEWEQD------- 2331
Query: 595 LQEMKEKKEAQLNNIDRLANTITMIEEEMVQLRKRYEKAVQHRNESGVQLIEREEEICIF 654
L+ +KEK E N L ++ + + + H QL E+I
Sbjct: 2332 LKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQ---DNKNPHVTSRATQL--TTEKIREL 2386
Query: 655 YEKINIQEKMKLNGEIEIHLLEEKIQFLKMKIAEKQRQICVTQKLL-PAKRSLDADLAVL 713
++ ++ ++ E +I ++++++ IA+ Q ++ + K L K ++ +
Sbjct: 2387 ENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKV 2446
Query: 714 QIQFSQCTDRIKDLEKQFVKPDGENRARFLPGKDLTEKEMIQKLDKLELQLAKKEEKLLE 773
+ + I+DL+ + VK D E K+ E E K ++ K+ +LL
Sbjct: 2447 ALGAKPYKEEIEDLKMKLVKIDLEKM------KNAKEFEKEISATKATVEYQKEVIRLLR 2500
Query: 774 KDFIYEQVSRLTDRLCSKTQGCKQDTLLLAKKMNGYQRRIKNATEKMMALVAELSMKQAL 833
++ Q ++ T + T + L +G + K AL+ + S L
Sbjct: 2501 ENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTK-------ALILK-SEHIRL 2552
Query: 834 TIELQKEVREKEDFIFTCNSRIEKGLPLNKEIEKEWLKVLRDEEMHALAIAEKS 887
E+ K ++ E I N + L+ E+ K W + E H E S
Sbjct: 2553 EKEISKLKQQNEQLIKQKNELLSNNQHLSNEV-KTWKERTLKREAHKQVTCENS 2605
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 107 bits (266), Expect = 7e-23
Identities = 181/838 (21%), Positives = 359/838 (42%), Gaps = 91/838 (10%)
Query: 98 QIQQQQFHLQQADNFPEAFSTEVSKMREQLLKYQNEYNAVKEREFHNQYRLNSLKEEKII 157
Q+ +Q+ LQ D E+ K++E+ K + E ++ + H Q L EEK I
Sbjct: 846 QVTRQEEELQAKDE-------ELLKVKEKQTKVEGELEEMERK--HQQ-----LLEEKNI 891
Query: 158 IVK----EFEKITKPGEMEKKMKILRESTEELRKEIMQKKLEIKNLREDLASKQKQLLKE 213
+ + E E + EM ++ ++ EE+ ++ + E + + L +++K++
Sbjct: 892 LAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAH 951
Query: 214 QKELEELLGHQVVLKDEVAHHQTIPVQIGKEIEKIT--RKKVEMEKKKIVLEQEVKTLND 271
++LEE L + + ++ ++EK+T K +ME++ ++LE +
Sbjct: 952 IQDLEEQLDEEEGARQKL------------QLEKVTAEAKIKKMEEEILLLEDQNSKFIK 999
Query: 272 SLKKVENKVSAIVDEKENVIKEVEGKRALLEIKEREHNQLVKLLE-LARENEATSLTERG 330
K +E++ I + + +E E + L +I+ ++ + L E L +E + E+
Sbjct: 1000 EKKLMEDR---IAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKA 1056
Query: 331 ILDL-----NLRNSLIDKQNYHDELSRKQREKERDFRNLRKM---ELLLK-VSWDALRQT 381
L +L++ + + Q DEL + +KE + + E L K + +R+
Sbjct: 1057 KRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVREL 1116
Query: 382 QALHQRLLLEMEAIPKDDSTLSERRRELHKEVEVAKRNLAQQKIISEMESKL---VEQQL 438
QA L + E+ + +++R+L +E+E K L + + +L EQ++
Sbjct: 1117 QAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEV 1176
Query: 439 AEENKLLKEQENMKELVVNLLRMTQIKIDEKEQKSKDFLKAQQKYTNIVKEMKAKDLEIR 498
AE K L+E+ E + +R Q E+ S+ +A++ N+ K + + +
Sbjct: 1177 AELKKALEEETKNHEAQIQDMR--QRHATALEELSEQLEQAKRFKANLEKNKQGLETD-- 1232
Query: 499 IHKKKKCEIYRRLREFAKLYDTIRNERNKFVNLLHKAHQKVNEIKERHKMSLNELEILRN 558
+K+ CE+ + ++ ++R K + + H KV+E +R ++ L E +
Sbjct: 1233 -NKELACEV----KVLQQVKAESEHKRKKLDAQVQELHAKVSE-GDRLRVELAE----KA 1282
Query: 559 SAVSQERKLQNSMLKHANNVTIRESMQNDVRKIVSKLQEMKEKKEAQLNNIDRLANTITM 618
S + E +++L+ A I+ D + S+LQ+ +E + + L++ I
Sbjct: 1283 SKLQNELDNVSTLLEEAEKKGIK--FAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQ 1340
Query: 619 IEEEMVQLRKRYEKAVQHRNESGVQLIEREEEICIFYEKINIQEKMKLNGEIEIHLLEEK 678
+EEE L+++ E+ + R Q++ + ++ +K++ G IE L E K
Sbjct: 1341 LEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDD-----LGTIE-SLEEAK 1394
Query: 679 IQFLKMKIAEKQR---QICVTQKLLPAKRSLDADLAVLQIQFSQCTDRIKDLEK------ 729
+ LK A QR + KL K L +L L + +LEK
Sbjct: 1395 KKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFD 1454
Query: 730 QFVKPDGENRARFLPGKDLTEKEMIQKLDKLELQLAKKEEKLLEKDFIYEQVSRLTDRLC 789
Q + + AR+ +D E E +K K L LA+ E+ LE +E+ ++
Sbjct: 1455 QLLAEEKSISARYAEERDRAEAEAREKETK-ALSLARALEEALEAKEEFERQNKQLRADM 1513
Query: 790 SKTQGCKQDTLLLAKKMNGYQRRIKNATEKMMALVAEL--------SMKQALTIELQKEV 841
K D ++ +R ++ E+M + EL K L + +Q
Sbjct: 1514 EDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMK 1573
Query: 842 REKEDFIFTCNSRIEKGLPLNKEIEKEWLKVLRDE-EMHALAIAEKSQEFLEADNRQL 898
+ E + T + + E+ L + +E L DE + ALA+A K + +E D + L
Sbjct: 1574 AQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKK--MEIDLKDL 1629
Score = 105 bits (261), Expect = 3e-22
Identities = 171/855 (20%), Positives = 374/855 (43%), Gaps = 135/855 (15%)
Query: 79 MSTQESEVQLLQNAKRF----TEQIQQQQFHLQQADNFPEAFSTEVSKMREQLLKYQNEY 134
+ +E Q L+ AKR T +Q Q LQ ++ +++ QL K + E
Sbjct: 1043 LKKEEKTRQELEKAKRKLDGETTDLQDQIAELQ----------AQIDELKLQLAKKEEEL 1092
Query: 135 NAVKER----EFHNQYRLNSLKEEKIIIVK-----EFEKITKPGEMEKKMKILRESTEEL 185
R H L ++E + I + E EK ++ + EK+ + L E E L
Sbjct: 1093 QGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASR-NKAEKQKRDLSEELEAL 1151
Query: 186 RKEIMQKKLEIKNLREDLASKQKQLLKEQKEL--EELLGHQVVLKDEVAHHQTIPVQIGK 243
+ E+ + L+ +++L +K++Q + E K+ EE H+ ++D H T ++ +
Sbjct: 1152 KTEL-EDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSE 1210
Query: 244 EIEKITRKKVEMEKKKIVLEQEVKTLNDSLKKVENKVSAIVDEKENVIKEVEGKRALLEI 303
++E+ R K +EK K LE + K L +K ++ + E E+ K+++ + L
Sbjct: 1211 QLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQ----VKAESEHKRKKLDAQVQELHA 1266
Query: 304 KEREHNQL-VKLLELARENEATSLTERGILDLNLRNSLIDKQNYHDELSRKQREKERDFR 362
K E ++L V+L E A + L+N L + +E +K + +D
Sbjct: 1267 KVSEGDRLRVELAEKASK---------------LQNELDNVSTLLEEAEKKGIKFAKDAA 1311
Query: 363 NLRKMELLLKVSWDALRQTQALHQRLLLEMEAIPKDDSTLSERRRELHKEVEVAKRNLAQ 422
+L E L+ + + L++ L + + ++ ++L E++ +E E A++NL +
Sbjct: 1312 SL---ESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQ----EEEEEARKNLEK 1364
Query: 423 QKIISEMESKLVEQQLAEENKLLKEQ----ENMKELVVNLLRMTQIKIDEKEQKSKDFLK 478
Q + ++ QLA+ K + + E+++E LL+ + E+K+ + K
Sbjct: 1365 QVL-------ALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDK 1417
Query: 479 AQQKYTNIVKEMKAKDLEIRIHKKKKCEIYRRLREFAKLYDTIRNERNKFVNLLHKAHQK 538
++ + +E+ +++ ++ + ++ ++F +L + E++ + +
Sbjct: 1418 LEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQL---LAEEKSISARYAEERDRA 1474
Query: 539 VNEIKERHKMSLNELEILRNSAVSQER-KLQNSMLKHANNVTIRESMQNDVRKIVSKLQE 597
E +E+ +L+ L + ++E + QN L+ ++ S ++DV K V +L++
Sbjct: 1475 EAEAREKETKALSLARALEEALEAKEEFERQNKQLR--ADMEDLMSSKDDVGKNVHELEK 1532
Query: 598 MKEKKEAQLNNIDRLANTITMIEEEMVQLRKRYEKAVQHRNESGVQLIEREEEICIFYEK 657
K E Q+ EEM + E +Q ++ ++L + + +E+
Sbjct: 1533 SKRALEQQV--------------EEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFER 1578
Query: 658 INIQEKMKLNGEIEIHLLEEKIQFLKMKIAEKQRQICVTQKLLPAKRSLDADLAVLQIQF 717
++Q + + N E + LL ++++ L+ ++ ++++Q + + +K+ ++ DL
Sbjct: 1579 -DLQTRDEQNEE-KKRLLIKQVRELEAELEDERKQRALA---VASKKKMEIDL------- 1626
Query: 718 SQCTDRIKDLEKQFVKPDGENRARFLPGKDLTEKEMIQKLDKLELQLAKKEEKLLEKDFI 777
KDLE Q + N+AR E+I++L KL+ Q+ + +L E
Sbjct: 1627 -------KDLEAQI---EAANKAR---------DEVIKQLRKLQAQMKDYQRELEEARAS 1667
Query: 778 YEQVSRLTDRLCSKTQGCKQDTLLLAKKMNGYQR--------------RIKNATEKMMAL 823
+++ + K + + + L L +++ +R I N+ AL
Sbjct: 1668 RDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSAL 1727
Query: 824 VAELSMKQALTIELQKEVREKEDFIFTCNSRIEKGLPLNKEIEKEWLKVLRDEEMHALAI 883
+ E +A +L++E+ E++ + N R K ++ + L E A
Sbjct: 1728 LDEKRRLEARIAQLEEELEEEQSNMELLNDRFRK-----TTLQVDTLNAELAAERSAAQK 1782
Query: 884 AEKSQEFLEADNRQL 898
++ +++ LE N++L
Sbjct: 1783 SDNARQQLERQNKEL 1797
Score = 91.3 bits (225), Expect = 4e-18
Identities = 152/784 (19%), Positives = 331/784 (42%), Gaps = 100/784 (12%)
Query: 81 TQESEVQLLQNAKRFTEQIQQQQFHLQQADNFP---EAFSTEVSKMREQLLKYQNEYNAV 137
T+ E Q+ +R +++ L+QA F E + ++L V
Sbjct: 1187 TKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQV 1246
Query: 138 KEREFHNQYRLNSLKEEKIIIVKEFEKI-TKPGEMEKKMKILRESTEELRKEIMQKKLEI 196
K H + +L++ +E V E +++ + E K++ ++ L +E +K ++
Sbjct: 1247 KAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKF 1306
Query: 197 KNLREDLASKQKQLLKEQKELEELLGHQVVLKDEVAHHQTIPVQIGKEIEKITRKKVEME 256
+D AS + QL Q+ L+E ++ L + + + ++ E+ + +E
Sbjct: 1307 A---KDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLE 1363
Query: 257 KKKIVLEQEVKTLNDSLKKVEN---KVSAIVDEKENVIKEVEGKRALLEIKEREHNQLVK 313
K+ + L+ + L D+ KKV++ + ++ + K+ ++K+ E LE K +++L K
Sbjct: 1364 KQVLALQSQ---LADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEK 1420
Query: 314 LLELARENEATSLTERGILDLNLRNSLIDKQNYHDEL--------SRKQREKERDFRNLR 365
++ E LT + ++L KQ D+L +R E++R R
Sbjct: 1421 TKNRLQQ-ELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAR 1479
Query: 366 KMEL-------LLKVSWDALRQTQALHQRLLLEMEAIPKDDSTLSERRRELHKEVEVAKR 418
+ E L+ + +A + + +++L +ME + + + EL K +KR
Sbjct: 1480 EKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEK----SKR 1535
Query: 419 NLAQQKIISEMESKLVE---QQLAEENKLLKEQENMKELVVNLLRMTQIKIDEKEQKSKD 475
L QQ + EM ++L E + A E+ L+ + NM+ + R Q + DE+ ++ K
Sbjct: 1536 ALEQQ--VEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTR-DEQNEEKKR 1592
Query: 476 FLKAQQKYTNIVKEMKAKDLEIRIHKKKKCEIYRRLREFAKLYDTIRNERNKFVNLLHK- 534
L Q + E + K + + KKK EI L++ + R++ + L K
Sbjct: 1593 LLIKQVRELEAELEDERKQRALAVASKKKMEI--DLKDLEAQIEAANKARDEVIKQLRKL 1650
Query: 535 -------------AHQKVNEIKERHKMSLNELEILRNSAVSQERKLQNS--MLKHA---- 575
A +EI + K S +L+ L + + +L +S +HA
Sbjct: 1651 QAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQER 1710
Query: 576 --------NNVTIRESMQNDVRKIVSKLQEMKEKKEAQLNNIDRLANTI--TMIEEEMVQ 625
N+ + + ++ ++ R++ +++ +++E+ E + +N++ L + T ++ + +
Sbjct: 1711 DELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLN 1770
Query: 626 LRKRYEKAVQHRNESGVQLIEREEEICIFYEKINIQE---KMKLNGEIEIHLLEEKIQFL 682
E++ ++++ Q +ER+ + K +QE +K + I LE KI L
Sbjct: 1771 AELAAERSAAQKSDNARQQLERQNKEL----KAKLQELEGAVKSKFKATISALEAKIGQL 1826
Query: 683 KMKIAEKQRQICVTQKLLPAKRSLDADLAVLQIQFSQCTDRIKDLEKQFVKPDGENRARF 742
+ ++ ++ ++ KL+ K L++ F++ + E R
Sbjct: 1827 EEQLEQEAKERAAANKLVRRTE--------------------KKLKEIFMQVEDERR-HA 1865
Query: 743 LPGKDLTEKEMIQKLDKLELQLAKKEEKLLEKDFIYEQVSRLTDRLCSKTQGCKQDTLLL 802
K+ EK ++ +L+ QL + EE+ + ++ R D +G ++ L
Sbjct: 1866 DQYKEQMEKAN-ARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTL 1924
Query: 803 AKKM 806
++
Sbjct: 1925 KNRL 1928
Score = 78.6 bits (192), Expect = 3e-14
Identities = 97/431 (22%), Positives = 198/431 (45%), Gaps = 44/431 (10%)
Query: 477 LKAQQKYTNIVKEMKAKDLEIRIHKKKKCEIYRRLREFAKLYDTIRNERNKFVNLLH--- 533
+K + T +E++AKD E+ K+K+ ++ L E + + + E+N L
Sbjct: 841 VKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAET 900
Query: 534 KAHQKVNEIKERHKMSLNELEILRNSAVS--QERKLQNSMLKHANNVTIRESMQNDVRKI 591
+ + E++ R ELE + + S +E + +N +L++ ++ MQ ++ +
Sbjct: 901 ELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNE-----KKKMQAHIQDL 955
Query: 592 VSKLQEMK-EKKEAQLNNIDRLANTITMIEEEMVQLRKRYEKAVQHRNESGVQLIEREEE 650
+L E + +++ QL + A I +EEE++ L + K ++ + ++ E +
Sbjct: 956 EEQLDEEEGARQKLQLEKVTAEAK-IKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQ 1014
Query: 651 ICIFYEKINIQEKMKLNGEIEIHLLEEKIQFLKMKIAEKQRQICVTQKLLPAKRSLDADL 710
+ EK K++ E+ I LEE ++K EK R Q+L AKR LD +
Sbjct: 1015 LAEEEEKAKNLAKIRNKQEVMISDLEE-----RLKKEEKTR-----QELEKAKRKLDGET 1064
Query: 711 AVLQIQFSQCTDRIKDLEKQFVKPDGENRARFLPGKD--LTEKEMIQKLDKLELQLAKKE 768
LQ Q ++ +I +L+ Q K + E + G D L + ++ + +L+ Q+A+
Sbjct: 1065 TDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAE-- 1122
Query: 769 EKLLEKDFIYEQVSRLTDRLCSKTQGCKQDTLLLAKKMNGYQRRIKNATEKMMALVAELS 828
L++DF E+ SR +K + K+D L++++ + +++ + A +
Sbjct: 1123 ---LQEDFESEKASR------NKAEKQKRD---LSEELEALKTELEDTLDTTAAQQELRT 1170
Query: 829 MKQALTIELQKEVREKEDFIFTCNSRIE-KGLPLNKEIEKEWLKVLRDEEMHALAIAEKS 887
++ EL+K + E+ T N + + + E L ++ A EK+
Sbjct: 1171 KREQEVAELKKALEEE-----TKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKN 1225
Query: 888 QEFLEADNRQL 898
++ LE DN++L
Sbjct: 1226 KQGLETDNKEL 1236
>gi|32698688 citron [Homo sapiens]
Length = 2027
Score = 106 bits (265), Expect = 9e-23
Identities = 173/931 (18%), Positives = 387/931 (41%), Gaps = 80/931 (8%)
Query: 4 SSTDTEKEEEEEKDEKDQEPIYAIVPT-INIQDERFVDLSETPAFIFLHELHAM--GKLP 60
S DT +E EK+ + P+ + ++ FV S + A L ++ G
Sbjct: 381 SDDDTSNFDEPEKNSWVSSSPCQLSPSGFSGEELPFVGFSYSKALGILGRSESVVSGLDS 440
Query: 61 GTRMAALKAKYTLLHDAVMSTQESEVQLLQNAKRFTEQIQQQQFHLQQADNFPEAFSTEV 120
+ ++++ K + + +Q+ ++ Q R ++ + + L Q + +A T+
Sbjct: 441 PAKTSSMEKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQR 500
Query: 121 SKMREQLLKYQNEYNAVK-----------EREFHNQYRLNSLKEE--KIIIVKEFEKITK 167
S + + L Y E +++K + + L+ ++E+ K+ +KE E +
Sbjct: 501 SLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQ 560
Query: 168 PGEMEKKMKILRESTEELRK-------EIMQKKLEIKNLREDLASKQKQLLKEQKELEEL 220
EM M L E R+ E+ + +L + + Q +LLK + + +
Sbjct: 561 VEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQGKPE 620
Query: 221 LGHQVVLKDEVAHHQTIPVQIGKEIEKITRKKVEMEKKKIVLEQEVKTLNDSLKKVENKV 280
+G L+ A Q ++ +++EK + E + + Q + L+K++N+
Sbjct: 621 VGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNRE 680
Query: 281 SAIVDEKENVIKEVEGKRALLEIKEREHNQLVKLLELARENEATSLTER-GILDLNLRNS 339
+ ++ +++ E LE K RE + LE+ + + E+ +LD ++
Sbjct: 681 DSSEGIRKKLVEAEE-----LEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKD 735
Query: 340 LIDKQNYHDELSRKQREKERDFRNLRKMELLLKVSWDALRQTQALHQRLLLEMEA----- 394
L DK+ + + R + E + L + + ++ +R +L QR++ EA
Sbjct: 736 LADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIR---SLEQRIVELSEANKLAA 792
Query: 395 ---------IPKDDSTLSE-RRRELHKEVEVAKRNLAQQKIISEMESKLVEQQLAEENKL 444
+ + +SE R+++ + E + K AQ + + E K+ Q +++N+L
Sbjct: 793 NSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLE-AQNRKLEEQLEKISHQDHSDKNRL 851
Query: 445 LKEQENMKELVVNLLRMTQIKIDEKEQKSKDFLKAQQKYTNIVKEMKAK---DLEIRIHK 501
L+ + ++E+ L + K++ K Q ++ L Q++ + + A+ + ++R K
Sbjct: 852 LELETRLREV---SLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAK 908
Query: 502 KKKCEIYRRLREFAKLYDTIRNERNKFVNLLHKAHQKVNEIKERHKMSLNELEILRNSAV 561
+ E E + R+E + + L + + +++E+ + L N
Sbjct: 909 TELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNF 968
Query: 562 SQERKLQNSMLKHANNVTIRESMQNDVRKIVSKLQEMKEKKEAQLNNIDRLANTITMIEE 621
++L + + V +R + + R+I + ++ +K+ ++ L T TM+EE
Sbjct: 969 YLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQ----TMEALKTTCTMLEE 1024
Query: 622 EMVQLR----KRYEKAVQHRNESGVQLIEREEEICIFYEKINIQEKMKLNGEIEIHLLEE 677
+++ L + EK Q V E+ + C E + + K + + E
Sbjct: 1025 QVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITE 1084
Query: 678 KIQFLKMKIAEKQRQICVTQKLLPAKRSLDADLAVLQIQFSQCTDRIKDLEKQFVKPDGE 737
Q +++ + E + +I Q+ L ++ ++ +D++ DLEK+ E
Sbjct: 1085 SRQVVELAVKEHKAEILALQQALKEQK----------LKAESLSDKLNDLEKKHAML--E 1132
Query: 738 NRARFLPGKDLTEKEMIQKLDKLELQLAKKEEKLLEKDFIYEQVSRLTDRLCSKTQGCKQ 797
AR L K TE+E+ Q+L LE Q +++ L+K+ I+ L + L + K
Sbjct: 1133 MNARSLQQKLETERELKQRL--LEEQAKLQQQMDLQKNHIFRLTQGLQEAL-DRADLLKT 1189
Query: 798 DTLLLAKKMNGYQRRIKNATEKMMALVA-ELSMKQALTIELQKEVREKEDFIFTCNSRIE 856
+ L ++ Q + KM ++ + + L ++ + ++K+ + +
Sbjct: 1190 ERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLF--SRRKED 1247
Query: 857 KGLPLNKEIEKEWLKVLRDEEMHALAIAEKS 887
LP ++ LK+ ++E A E++
Sbjct: 1248 PALPTQVPLQYNELKLALEKEKARCAELEEA 1278
>gi|154354990 ankyrin repeat domain 26 [Homo sapiens]
Length = 1710
Score = 106 bits (264), Expect = 1e-22
Identities = 154/756 (20%), Positives = 325/756 (42%), Gaps = 94/756 (12%)
Query: 63 RMAALKAKYTLLHDAVMSTQESEVQLLQNAKRFTEQIQQQQFHLQQADNFPEAFSTEVSK 122
++ ++ K +L + T+E + QL + ++ +F L Q + T K
Sbjct: 752 KIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEK 811
Query: 123 MREQLLKYQNEYNAVKEREFHNQYRLNSLKEEKIIIVKEFEKITKPGEMEKKMKILREST 182
+REQL + + +Y KE E Q L+ + E E T + + ++ ++
Sbjct: 812 IREQLRRKEEQYR--KEVEVKQQLELS-------LQTLEMELRTVKSNLNQVVQERNDAQ 862
Query: 183 EELRKEIMQKKLEIKNLREDLASKQKQLLKEQKELEELLGHQVVLKDEVAHHQTI----P 238
+L +E + L+ L L SKQK++ QK++ H + +++H ++
Sbjct: 863 RQLSREQNARMLQDGILTNHL-SKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEI 921
Query: 239 VQIGKEIEKITRKKVEMEKK-----KIVLEQEVKTLNDSLKKVENKVSAIVDEKENVIKE 293
+ EI+ I + E EKK KIV E+ + L ++K+ E ++ + + +
Sbjct: 922 AMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKN-EDLQKTIKQNEETLTQTISQYNGRLSV 980
Query: 294 VEGKRALLEIKEREHNQLVKLLELARENE----ATSLTERGILDLNLRNSLIDKQNYHDE 349
+ + A+L K Q + LE E+ A ++ +R + + R + Q DE
Sbjct: 981 LTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDE 1040
Query: 350 LSRKQREKERDFRNLR-----------KMELLLKVSWDALRQTQALHQRLLLEMEAIPKD 398
SR Q + D NL+ K E L T+ + L +E + KD
Sbjct: 1041 CSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKD 1100
Query: 399 DSTLSERRRELHKEVEVAKRNLAQQKIISEMESKLVEQ---QLAEENKLLKEQ------- 448
S + +E+ ++ + + K I + ES VE+ QL EN LL++Q
Sbjct: 1101 LSQTQCQMKEMEQKYQ--NEQVKVNKYIGKQES--VEERLSQLQSENMLLRQQLDDAHNK 1156
Query: 449 -ENMKELVVNLLRMTQIKIDEKEQKS-KDFLKAQQKYTNIVKE---MKAKDLEIRIHKKK 503
+N ++ V+N+ + + + +S K L +++ ++ E +K + + K +
Sbjct: 1157 ADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAE 1216
Query: 504 KCEIYRRLREFAKLYDTIRNERNKFVNLLHKAHQKVNEIKERHKMSL-NELEILRNSAVS 562
+ + R+L++ +L DT++ + +L E+ R++++L +E + L+
Sbjct: 1217 REVVVRQLQQ--ELADTLKKQSMSEASL---------EVTSRYRINLEDETQDLKKKLGQ 1265
Query: 563 QERKLQNSMLKHANNVTIRESMQNDVRKIVSKLQEMKEKKEAQLNNIDRLANTI---TMI 619
+LQ + +H V E MQ+ +K+ ++K + Q++ I+ L + +
Sbjct: 1266 IRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLS 1325
Query: 620 EEEMVQLRKRYEKAVQHRNESGVQLIEREEEICIFYEKINIQEKMKLNGEIEIHL--LEE 677
E+E QL+K L+E ++ + + N+ ++MK N E+E + +
Sbjct: 1326 EDEKEQLKK---------------LMELKQSL-----ECNLDQEMKKNVELEREITGFKN 1365
Query: 678 KIQFLKMKIAEKQR-QICVTQKLLPAKRSLDADLAVLQIQFSQCTDRIKDLEKQFVKPDG 736
++ + K+ E + + L ++ +D + L+ + T ++ + + D
Sbjct: 1366 LLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDT 1425
Query: 737 ENRARFLPGKDLTEKEMIQKLDKLELQLAKKEEKLL 772
+N + L + L+ K + +K +KL+ K E++++
Sbjct: 1426 KN--QILQEELLSMKTVQKKCEKLQKNKKKLEQEVI 1459
Score = 48.9 bits (115), Expect = 2e-05
Identities = 90/446 (20%), Positives = 186/446 (41%), Gaps = 67/446 (15%)
Query: 101 QQQFH--LQQADNFPEAFSTEVSKMREQLLKYQNEYNAVKEREFHNQYRLNSLKEEKIII 158
Q QFH +Q+ E S + + ++L+ +E N +KER QY+ + K E+ ++
Sbjct: 1168 QDQFHAIVQKLQAESEKQSLLLEERNKELI---SECNHLKER----QYQYENEKAEREVV 1220
Query: 159 VKEFEK-----ITKPGEMEKKMKILRESTEELRKEIMQKKLEIKNLREDLASKQKQLLKE 213
V++ ++ + K E +++ L E K ++ +R L Q + +
Sbjct: 1221 VRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEA 1280
Query: 214 QKELEELLGHQVVL-KDEVAHHQTIPVQIGK-------------------EIEKITRKKV 253
+ E++ H+ L KD T+ Q+ K +++K+ K
Sbjct: 1281 VRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKLMELKQ 1340
Query: 254 EME-------KKKIVLEQEVKTLNDSLKKVENKVSAIVDEKENVIKEVEG--KRALLEIK 304
+E KK + LE+E+ + LK K++ E EN G K + E+
Sbjct: 1341 SLECNLDQEMKKNVELEREITGFKNLLKMTRKKLN----EYENGEFSFHGDLKTSQFEMD 1396
Query: 305 EREHNQLVKLLELARENEATSLTERGILDLNLRNSLIDK--------QNYHDELSRKQRE 356
+ + K+ +L E E L L+ +N ++ + Q ++L + +++
Sbjct: 1397 IQINKLKHKIDDLTAELETAGSK---CLHLDTKNQILQEELLSMKTVQKKCEKLQKNKKK 1453
Query: 357 KERDFRNLRKMELLLKVSWDALRQ-TQALHQRLLLEMEAIPKDDSTL------SERRREL 409
E++ NLR V ++Q Q + +R E+ K+ + S+ E
Sbjct: 1454 LEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKEVNLFLQAQAASQENLEQ 1513
Query: 410 HKEVEVAKRNLAQQKIISEMESKLVEQQLAEENKLLKEQENMKELVVNLLRMTQIKIDEK 469
+E A + I ++ES+L + + ++E+ E E K+L + L++ + + K
Sbjct: 1514 FRENNFASMKSQMELRIKDLESELSKIKTSQEDFNKTELEKYKQLYLEELKVRK-SLSSK 1572
Query: 470 EQKSKDFLKAQQKYTNIVKEMKAKDL 495
K+ + L A+ +V++ +++ L
Sbjct: 1573 LTKTNERL-AEVNTKLLVEKQQSRSL 1597
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 105 bits (263), Expect = 2e-22
Identities = 176/825 (21%), Positives = 341/825 (41%), Gaps = 126/825 (15%)
Query: 2 EDSSTDTEKEEEEEKDEKDQEPIYAIVPTINIQDERFVDLSETPAFIFLHELHAMGKLPG 61
E+ + T +EE ++ + + + + +N+Q + + LSE A I ++ K
Sbjct: 1350 ENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAI-----SSLRKQYD 1404
Query: 62 TRMAALKAKYTLLHDAVMSTQESEVQLLQN----AKRFTEQIQQQQFHLQQADNFPEAFS 117
L + L V + + ++ L+ + +F+E ++ Q Q N +
Sbjct: 1405 EEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQ 1464
Query: 118 TEVSKMREQLLKYQNEYNAVKEREFHNQYRLNSLKEEKIIIVKEFEKITKPGEMEKKMKI 177
++ ++ + + N +KE R + LK E + EK K +E ++K
Sbjct: 1465 IQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEK--KESNLETELKS 1522
Query: 178 LRESTEELRKEIMQKKLEIKNLREDLASKQKQLLKEQKELEELLGHQVVLKDEVAHH--- 234
EL I QK +EI++L E L + +Q E KEL + L H L +E +
Sbjct: 1523 QTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKE 1582
Query: 235 -----QTIPVQIGKEIEKITRKKVEMEKKKIVL---EQEVKTLNDSL------------K 274
T+ Q+ ++ KK E+E + + E+E+K L D L +
Sbjct: 1583 AEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKR 1642
Query: 275 KVENKVSAI-------VDEKENVIKE-VEGKRALLEIKEREHNQLVKLLELARENEATSL 326
K E K++AI ++EKE K+ E + L K +E + V +LE ++ +S
Sbjct: 1643 KAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQ 1702
Query: 327 TERGILDLNLRN-SLIDKQNYHDELSRKQREKERDF----RNLRKMELLLKVSWDALRQT 381
+E I+ + +N + +Q D Q+ E RNL + E LL+ +T
Sbjct: 1703 SETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEET 1762
Query: 382 QALH-------QRLLLEMEAIP----KDDSTLSERRREL-------------HKEVEVAK 417
+ H Q L+++E +D S + + EL H E E K
Sbjct: 1763 VSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGK 1822
Query: 418 RNLAQ-----------QKIISEME--SKLVEQQLAEENKLLKEQE-----NMKELVVNLL 459
N+ QK + E E +++EQ++ E + L Q+ M+EL
Sbjct: 1823 NNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYE 1882
Query: 460 RM------------TQIKIDEKEQKSKDFLKAQQKYTNIVKEMKAKDLEIRI--HKKKKC 505
++ T++ + E+KSK L + +N+ E + DLE ++ +++K
Sbjct: 1883 KLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNM--EAQHNDLEFKLAGAEREKQ 1940
Query: 506 EIYRRLREFAKLYDTIRNERNKFVNLLHKAHQKVNEIKERHKMSLNELEILRNSAVSQER 565
++ + + K +R E + + +L K + + E +E+ K +LE+ NS + Q
Sbjct: 1941 KLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQ--EREEKIKQEQEDLELKHNSTLKQLM 1998
Query: 566 KLQNSMLKHANNVTIRESMQNDVRKIVSKLQEMK-EKKEAQLNNIDRLANTITMIEEEMV 624
+ N+ L + ++ +++ ++K QE++ E E+ ++L I ++++
Sbjct: 1999 REFNTQLAQK-----EQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLK 2053
Query: 625 QLRKRYEKAVQHRNESGVQLIEREEEICIFYEKINIQEKMKLNGEIEIHLLEEKIQFLKM 684
+ KRYE+ + R E ++ + ++ E++ + + KL EE +
Sbjct: 2054 RTAKRYEEILDAREE---EMTAKVRDLQTQLEELQKKYQQKLE-------QEENPGNDNV 2103
Query: 685 KIAEKQRQICVTQKLLPAKRSLDADLAVLQIQFSQCTDRIKDLEK 729
I E Q Q+ L+ + + + + Q DR+K EK
Sbjct: 2104 TIMELQTQLAQKTTLISDSKLKEQE---FREQIHNLEDRLKKYEK 2145
Score = 105 bits (262), Expect = 2e-22
Identities = 202/970 (20%), Positives = 411/970 (42%), Gaps = 127/970 (13%)
Query: 1 MEDSSTDTEKEEEEEKDEKDQ--EPIYAIVPTINIQDERFVDLSETPAFIFLHELHAMGK 58
+E + + +K EE + K + E I I T +E + L + + + + M K
Sbjct: 416 LEKALSTAQKTEEARRKLKAEMDEQIKTIEKT---SEEERISLQQELSRVKQEVVDVMKK 472
Query: 59 LPGTRMAALKAKYTLLHDAVMSTQESEV--QLLQNAKRFTEQI-------QQQQFHLQQA 109
++A L+ LH+ ++ +E E+ +L + F EQ+ Q + + Q
Sbjct: 473 SSEEQIAKLQK----LHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQE 528
Query: 110 DNFPEAFSTEVSKMREQLLKYQNEYNAVKEREFHNQYRLNSLKEEKIIIVKEFEKITKPG 169
E+ + E +++++ + ++E ++ YR L+ E + E +
Sbjct: 529 KEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSK 588
Query: 170 EMEKKMKILRES-TEELRKEIMQKKLEIKNLRED---LASKQKQLLKEQ--KELEELLGH 223
++ ++ + +E+ + + K E+++L+ L +++ Q+LK+Q E+E+L
Sbjct: 589 DLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREK 648
Query: 224 -----QVVLKD-EVAHHQTIPVQIGKEIEKITRKKVEME----------KKKIVLEQEVK 267
+ +LKD E+ I K +EK+ K+ E+E K + LE+E+
Sbjct: 649 CEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELS 708
Query: 268 TLNDSLKKVENKVSAIVDEKEN--------VIKEVEGKRALLEIKEREHNQLVKLLELAR 319
L D K++ ++ A +DE++N +IKE E ++ E+ + LEL
Sbjct: 709 VLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHE---VSIQRTEKALKDQINQLELL- 764
Query: 320 ENEATSLTERGILDLNLRNSLIDKQNYHDELSRKQREKERDFRNLRKMELLLKVSWDALR 379
L ER D +L+ +N ++ R + E + + K+++
Sbjct: 765 ------LKER---DKHLKEHQAHVENLEADIKRSEGELQ---QASAKLDVFQSYQSATHE 812
Query: 380 QTQALHQRLL-LEMEAIPKDDSTLSERRRELHKEVEVAKRNLAQQKIISEMESKLVEQQL 438
QT+A ++L L+ + + + + ++ EVE K+++ + +++ + + QQL
Sbjct: 813 QTKAYEEQLAQLQQKLLDLETERILLTKQV--AEVEAQKKDVCTELDAHKIQVQDLMQQL 870
Query: 439 AEENKLLKEQENMKELVVNLLRMTQIKIDEKEQKSKDFLKAQQKYTNIVKEMKAKDLEIR 498
++N E+ + +TQ+ E K +D K Q++ I+ E + L++R
Sbjct: 871 EKQN---------SEMEQKVKSLTQV----YESKLEDGNKEQEQTKQILVEKENMILQMR 917
Query: 499 IHKKKKCEIYRRLREFAKLYDTIRNERNKFVNLLHKAHQKVNEIKERHKMSLNELEILRN 558
+KK+ EI ++ + D+I ++ +K+ ++K++ K E L+
Sbjct: 918 EGQKKEIEIL--TQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAK---EMQETLKK 972
Query: 559 SAVSQERKLQNSMLKHANNVTIRESMQNDVRKIVSKLQEMKEKKEAQLNN-IDRLANTIT 617
+ QE KL+ + A ++ +E N +K+ EM + A +++ + RL
Sbjct: 973 KLLDQEAKLKKELENTALELSQKEKQFN------AKMLEMAQANSAGISDAVSRLETNQK 1026
Query: 618 MIEEEMVQLRKR--------YEKAVQHRNES-----GVQLIEREEEICIFYEKINI--QE 662
E + ++ +R +EK + + E +QL E+E+E+ +KI + E
Sbjct: 1027 EQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCE 1086
Query: 663 KMKLNGEIEIHLLEEKIQFLKMKIAEKQRQI----CVTQKLLPAKRSLDADLAVLQIQFS 718
K ++N EI L EE ++ + E Q Q+ L + L A L L++ +
Sbjct: 1087 KEEMNKEI-TWLKEEGVK-QDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLN 1144
Query: 719 QCTDRIKDLEKQFVK-----PDGENRARFLPGKDLTEKEMIQKLDKLELQLAKK-EEKLL 772
+ L++Q V+ + + + L K T E Q L + K E+K L
Sbjct: 1145 KSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSL 1204
Query: 773 EKDFIYEQVSRLTDRLCSKTQG---CKQDTL--LLAKKMNGYQRRIKNATEKMMALVAEL 827
E + E+++ D C KT+ K + L + + K N RI + + + L
Sbjct: 1205 EFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEAL 1264
Query: 828 SMKQALTIELQKEVREKEDFIFTCNSRIEKGLPLNKEIEKEWLKVLRDEEMHALAIAEKS 887
+K EL+ ++R+ + T N ++ +E E + + D E + EK
Sbjct: 1265 LIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIES---LVTEKE 1321
Query: 888 QEFLEADNRQ 897
E N+Q
Sbjct: 1322 ALQKEGGNQQ 1331
Score = 101 bits (251), Expect = 4e-21
Identities = 169/823 (20%), Positives = 352/823 (42%), Gaps = 100/823 (12%)
Query: 82 QESEVQLLQNAKRFTEQIQQQQFHLQQADNFPEAFSTEVSKMREQLLKYQNEYNAVKERE 141
+ + ++L Q K+F ++ L+ A S VS++ + V RE
Sbjct: 986 ENTALELSQKEKQFNAKM------LEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRE 1039
Query: 142 FHN-----QYRLNSLKEE--KIIIVKEFEKITKPGEMEKKMKILRESTEELRKEIMQKKL 194
++ + +LN EE +I ++ EK + E+++K+ + EE+ KEI K
Sbjct: 1040 LNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKE 1099
Query: 195 EIKNLREDLASKQKQLLKEQKELEELLGHQVVLKDEVAHHQTIPVQIGKEIEKITRKKVE 254
E L Q+QL ++ + L + LK AH + + V + K +++ T + +
Sbjct: 1100 EGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLK---AHLEKLEVDLNKSLKENTFLQEQ 1156
Query: 255 MEKKKIVLEQE---VKTLNDSLKKVENKVSAIVDEKENVIKEVEGKRALLEIKEREHNQL 311
+ + K++ E++ V L LK + + ++ E K +E K LE K+
Sbjct: 1157 LVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKS--LEFKKLSEELA 1214
Query: 312 VKLLELARENEA---TSLTERGILDLNLRNSLIDKQNYHDELSRKQREK----------- 357
++L ++ EA E + + N+++ + ++ + K +E
Sbjct: 1215 IQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSEL 1274
Query: 358 ERDFRNLRKMELLLKVSWDALRQTQALHQRLLLE--MEAIPKDDSTLSERRRELHKEVEV 415
E R L + + L +S+ QA HQ E ++++ D +L + L KE
Sbjct: 1275 EAQLRQLTEEQNTLNISFQ-----QATHQLEEKENQIKSMKADIESLVTEKEALQKE--- 1326
Query: 416 AKRNLAQQKIISEMESKLVEQQLAEENKLLKEQENMKELVVNLLRMTQIKIDEKEQKSKD 475
QQ+ SE ES + + + K L E N L+ L+ +++I ++ D
Sbjct: 1327 ---GGNQQQAASEKESCITQLK-----KELSENINAVTLMKEELKEKKVEISSLSKQLTD 1378
Query: 476 FLKAQQKYTNIVKEMKAKDLEIRIHKKKKCEIYRRLREFAKLYDTIRNERNKFVNLLHKA 535
Q ++ ++ A + + ++KCE+ ++++ + DT+ E+ + +
Sbjct: 1379 LNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDW 1438
Query: 536 HQKVNEIKER-------HKMSLNELEIL--RNSAVSQERKLQNSMLKHANNV------TI 580
K +E K++ H+ ++ EL+I S + E+ Q ++LK + +
Sbjct: 1439 SNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCL 1498
Query: 581 RESMQNDVRKIVSKLQEMKEKKEAQLNNIDRLANTITM--IE-EEMVQLRKRYEKAVQHR 637
+ M++D K+ K ++ + ++Q I L + IT IE E + ++ K Y +
Sbjct: 1499 KGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIE 1558
Query: 638 NESGVQLI--------EREEEICIFYEKINIQEKMKLNGEIEIHLLEEKIQFLKMKIAEK 689
++ VQ + E++ + EKI E + + E+ +++++ + + + K
Sbjct: 1559 HKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSK 1618
Query: 690 QRQICVTQKLLPAKRSLDADLAVLQIQFSQCTDRIKDLEKQFVKPDGENRARFLPGKDLT 749
+ ++ + L ++ + A LA L+ + Q +I ++KQ + E ++ G +
Sbjct: 1619 EEELKALEDRLESESA--AKLAELKRKAEQ---KIAAIKKQLLSQMEEKEEQYKKGTESH 1673
Query: 750 EKEMIQKLDKLELQLAKKEEKLLEKDFIYEQ----------VSRLTDRLCSKTQGCKQDT 799
E+ KL + E ++ EEKL + + V+ T++ + +QGC Q T
Sbjct: 1674 LSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKT 1733
Query: 800 LLLAKKMNGYQRRIKNATEKMMALVAELSMKQALTIELQKEVR 842
+K++ QR N TEK L+ + ++ T+ E+R
Sbjct: 1734 --YEEKISVLQR---NLTEK-EKLLQRVGQEKEETVSSHFEMR 1770
Score = 92.4 bits (228), Expect = 2e-18
Identities = 184/867 (21%), Positives = 372/867 (42%), Gaps = 113/867 (13%)
Query: 79 MSTQESEVQLLQNA-KRFTEQIQQQQFHLQQADNFPEAFSTEVSKMREQLLKYQNEYNAV 137
+ T + V+ +N KR E IQ + + EA ++ + ++L K ++ + A
Sbjct: 281 LETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAE 340
Query: 138 KEREFHNQYR-----LNSLKEEKIIIVKEFEKITKPGEMEKKMKILRESTEELRKEIMQK 192
K + Q R + L+++K +++ E ++ +M + +++ E +LR I Q
Sbjct: 341 KTKLI-TQLRDAKNLIEQLEQDKGMVIAETKR-----QMHETLEMKEEEIAQLRSRIKQM 394
Query: 193 KLEIKNLREDLASKQKQLLKEQKELEELLGHQVVLKDEVAHHQTIPVQIGKEIEKITRKK 252
+ + LRE K+K +ELE+ L K E A + + ++ ++I+ I +
Sbjct: 395 TTQGEELRE---QKEKSERAAFEELEKAL--STAQKTEEARRK-LKAEMDEQIKTIEKTS 448
Query: 253 VEMEKKKIVLEQEVKTLNDSL-----KKVENKVSAI--VDEKENVIKEVEGKRALLEIKE 305
E+++I L+QE+ + + K E +++ + + EKE KE E + L+ +E
Sbjct: 449 ---EEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKK-LQTRE 504
Query: 306 REHNQLVKL---------LELARENEATSLTERGILDLNLRNSLIDKQNYHDELSRKQRE 356
RE + +K+ L++++E E L+L + L + +N +L Q+E
Sbjct: 505 REFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESEN---KLRDLQQE 561
Query: 357 KERDFRNLRKMELLLKVSWDALRQTQALHQRLLLEMEAIPKDDSTLSERRRELHK-EVEV 415
E + ++E L+ S L++ + + L + +EA + E HK E+E
Sbjct: 562 AETYRTRILELESSLEKS---LQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELES 618
Query: 416 AKRNLAQQKIISEMESKLVEQQLAEENKLLKEQENMKE-LVVNLLRMTQIKIDEKEQKSK 474
K Q + +E L +Q E KL ++ E KE L+ + + Q I+E +K+
Sbjct: 619 LKHQ--QDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTL 676
Query: 475 DFLKAQQKYTNIVKEMKAKDLEIRIHKKKKCEIYRRLREFAKLYDTIRNERNKFVNLLHK 534
+ L +Q E+++ E+ K + ++ L D ++ E ++
Sbjct: 677 EKLDVKQ------TELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKN 730
Query: 535 AH-QKVNEIKERHKMSLNELEILRNSAVSQERKLQNSMLKHANNVTIR-ESMQNDVRKIV 592
H Q+V+ I + H++S+ E ++Q L KH E+++ D+++
Sbjct: 731 HHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSE 790
Query: 593 SKLQEMKEKKEAQLNNIDRLANTITMIEEEMVQLRKRYEKAVQHRNESGVQLIE---REE 649
+LQ+ K + + EE++ QL+++ R Q+ E +++
Sbjct: 791 GELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKK 850
Query: 650 EIC--IFYEKINIQEKM----KLNGEIEIHLLEEKIQFLKMKIAEKQRQICVTQKLLPAK 703
++C + KI +Q+ M K N E+E ++ Q + K+ + ++ T+++L K
Sbjct: 851 DVCTELDAHKIQVQDLMQQLEKQNSEME-QKVKSLTQVYESKLEDGNKEQEQTKQILVEK 909
Query: 704 RSLDADLAVLQIQFSQ------CTDRIKDLEKQFVKPDGENRARFLPGKDLTEKEMIQKL 757
++ +LQ++ Q T ++ E + E +F K +K+
Sbjct: 910 ENM-----ILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKF--------KNQEKKM 956
Query: 758 DKLELQLAKKEEKLLEKDFIYEQVSRLTDRLCSKTQGCKQDTLLLAKKMNGYQRRIKNAT 817
+K++ Q AK+ ++ L+K +L D+ + + L L++K + ++
Sbjct: 957 EKVK-QKAKEMQETLKK--------KLLDQEAKLKKELENTALELSQKEKQFNAKMLEMA 1007
Query: 818 EKMMA----LVAELSMKQALTIELQKEV--REKEDFIFTCNSRIEKGLPLNKEIEKEWLK 871
+ A V+ L Q IE EV RE D I + LN++ E+
Sbjct: 1008 QANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKK------LNQQAEEL--- 1058
Query: 872 VLRDEEMHALAIAEKSQEFLEADNRQL 898
+E+H + + EK QE E + L
Sbjct: 1059 ----QEIHEIQLQEKEQEVAELKQKIL 1081
Score = 60.5 bits (145), Expect = 7e-09
Identities = 130/685 (18%), Positives = 261/685 (38%), Gaps = 111/685 (16%)
Query: 197 KNLREDLASKQKQLLKEQKELEELLGHQVVLKDEVAHHQTIPVQIGKEIEKITRKKVEME 256
K L++ ++ +Q+QL Q + + + + + P ++ T + E
Sbjct: 3 KKLKQKISEEQQQL------------QQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGT 50
Query: 257 KKKIVLEQEVKTLNDSLKKVENKVSAIVDEKENVIKEV----EGKRALLEIKEREHNQLV 312
+ E +K++ +V ++ + IKE K +L+ RE +
Sbjct: 51 PNR-----ESGDTQSFAQKLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRL 105
Query: 313 KLLELARENEATSLTERGILDLNLRNSLIDKQNYHDELSRKQREKERDFRNLRKMELLLK 372
L + S + DL + ++K+ +L ++ R ER + R L
Sbjct: 106 DLDSSTASFDPPSDMDSEAEDLVGNSDSLNKE----QLIQRLRRMERSLSSYRGKYSELV 161
Query: 373 VSWDALRQTQALHQRLLLEMEAIPKDDSTLSERRRELHKEVEVAKRNLAQQKIISEMESK 432
++ L++ + Q +L + + K ++E R EL + + AK++L ++ S E
Sbjct: 162 TAYQMLQREKKKLQGILSQSQ--DKSLRRIAELREELQMDQQ-AKKHLQEEFDASLEEKD 218
Query: 433 LVEQQLAEENKLLKEQENMKELVVNLLRMTQIKIDEKEQKSKDFLKAQQKYTNIVKEMKA 492
L + LLK++ + V++L+ + + E +++ F K +E
Sbjct: 219 QYISVLQTQVSLLKQRLRNGPMNVDVLK----PLPQLEPQAEVFTK---------EENPE 265
Query: 493 KDLEIRIHKKKKCEIYRRLREFAKLYDTIRNERNKFVNLLHKAHQKVNEIKERHKMSLNE 552
D E + K +T++ + NLL + + + KE+ + +E
Sbjct: 266 SDGEPVVEDGTS----------VKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSE 315
Query: 553 LEILRNSAVSQERKLQNSMLKHANNVTIRESMQNDVRKIVSKLQEMKEKKEAQLNNIDRL 612
E L+ + ++L+ H T + D + ++ +L++ K A+ ++
Sbjct: 316 KEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKR--QM 373
Query: 613 ANTITMIEEEMVQLRKRYEKAVQHRNESGVQLIEREEEICIFYEKINIQEKMKLNGEIEI 672
T+ M EEE+ QLR R ++M GE
Sbjct: 374 HETLEMKEEEIAQLRSRI-------------------------------KQMTTQGE--- 399
Query: 673 HLLEEKIQFLKMKIAEKQRQICVTQKLLPAKRSLDADLAVLQIQFSQCTDRIKDLEKQFV 732
L E+K + + E ++ + QK A+R L A++ ++IK +E
Sbjct: 400 ELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEM----------DEQIKTIE---- 445
Query: 733 KPDGENRARFLPGKDLTEKEMIQKLDKLELQLAKKEEKLLEKDFIYEQVSRLTDRLCSKT 792
K E R ++E++ + K + K +KL EK+ ++ LT +L ++
Sbjct: 446 KTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKE-QELTKKLQTRE 504
Query: 793 QGCKQDTLLLAKKMNGYQRRIKNATEKMMALV---AELSMKQALT------IELQKEVRE 843
+ ++ + +K +I E+ +L EL K LT +LQ+E
Sbjct: 505 REFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAET 564
Query: 844 KEDFIFTCNSRIEKGLPLNKEIEKE 868
I S +EK L NK K+
Sbjct: 565 YRTRILELESSLEKSLQENKNQSKD 589
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 105 bits (262), Expect = 2e-22
Identities = 216/993 (21%), Positives = 429/993 (43%), Gaps = 154/993 (15%)
Query: 9 EKEEEEEKDEKD----QEPIYAIVPTIN----IQDERFVDLSETPAFIFLHELHAMGKLP 60
EK++E ++ +KD QE I A+ T+ +Q E DL T + H K
Sbjct: 2016 EKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHR--KKA 2073
Query: 61 GTRMAALKAKYTLLHDAVMSTQESEVQLLQNAKRFTEQIQQQQFHLQQADNFPEAFSTEV 120
+A+ K LL D TQ ++L + + +++Q + E+ +++
Sbjct: 2074 QAELASFKV---LLDD----TQSEAARVLADNLKLKKELQSNK----------ESVKSQM 2116
Query: 121 SKMREQLLKY--QNEYNAVKEREFHNQYRLNSLKEEKIIIVKEFEKITKPGEMEKKMKIL 178
+ E L + Q E +KE++ + Q +L++L+ EK+ + + +I + KK K +
Sbjct: 2117 KQKDEDLERRLEQAEEKHLKEKK-NMQEKLDALRREKVHLEETIGEIQVT--LNKKDKEV 2173
Query: 179 RESTEELRKEIMQKKLEIKNLREDLASKQKQLLKEQKELEELLGHQVVLKDEVAHHQTIP 238
++ E L + Q K++ L + +++ E K+ E + K+E +
Sbjct: 2174 QQLQENLDSTVTQLAAFTKSM-SSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDN 2232
Query: 239 VQIGKEIEKITRKKVEMEKKKIVLEQEVKTLNDSLKKVENKVSAIVDEKENVIKEVEG-- 296
+ K+ ++ + + ME+ KI + L + E+K V ++ V ++G
Sbjct: 2233 CSVLKD--QLRQMSIHMEELKI----NISRLEHDKQIWESKAQTEVQLQQKVCDTLQGEN 2286
Query: 297 KRALLEIKEREHNQLVKLLELAR-ENEATSLTERGILDLNLRNSLIDKQNYHDELSRKQR 355
K L +++E H ELA+ E+E SL ++ + DL+ NSL + L R
Sbjct: 2287 KELLSQLEETRHLYHSSQNELAKLESELKSLKDQ-LTDLS--NSLEKCKEQKGNLEGIIR 2343
Query: 356 EKERDFRNLRKMELLLKVSWDALRQ-TQALHQRLLLEMEAIPKDDSTLSERRRELHKEVE 414
++E D +N + L+ A R+ T LH+ + ++ + I S LS + + +V
Sbjct: 2344 QQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKII---SLLSGKEEAI--QVA 2398
Query: 415 VAKRNLAQQKIISEMESKLVEQQLAEENKLLKEQENMKELVVNLLRMTQIKIDEKE---Q 471
+A+ K I E+E+ L ++ EE ++ E+EN K + M +K +KE Q
Sbjct: 2399 IAELRQQHDKEIKELENLLSQE---EEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQ 2455
Query: 472 KSK--DFLKAQQKYTN----IV---KEMKAKDLEIRIHKKKKCEIYRRLREFAKLYDTIR 522
K++ F+K+ N IV ++++ + L I + K + I E KL + IR
Sbjct: 2456 KAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQL--IQEAAAENNKLKEEIR 2513
Query: 523 NERNKFVNLLHKAHQKVNEIKERHKMSLNELEILRNSA--------VSQERKLQNSMLKH 574
R+ +L + + K++ +++ LN++ +++S + Q ++L+N K
Sbjct: 2514 GLRSHMDDL-NSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKL 2572
Query: 575 ANNVTIRESMQNDVRKIVSKLQEMKEKKEAQLNN----IDRLANTITMIEEE------MV 624
+ E D+R+ + LQE K+ ++ + I +L +T ++EE
Sbjct: 2573 EEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHA 2632
Query: 625 QLRKRYEKAVQHR-----NESGVQLIEREEE-ICIFYEKIN----IQEKMK-----LNGE 669
QL+ + E+ HR + S ++ E EEE +C+ E I++K+K L+ +
Sbjct: 2633 QLKVKEEEV--HRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHD 2690
Query: 670 I-----EIHLLEEKIQFLKMKIAEKQRQICVTQK----LLPAKRSLDADLAVLQIQFSQC 720
E EE++ L + E ++++ + K L +S ++ LQ
Sbjct: 2691 AGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHA 2750
Query: 721 TDRIKDLEKQF---------VKPDGE-NRARFLP------GKDLTEKEMIQKLDKLELQL 764
+ + +L++++ +K G NR R + TE+ + L+KL QL
Sbjct: 2751 NEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQL 2810
Query: 765 AKKEEKLL----EKDFIYEQVSRLTDRLCSKTQGCKQDTLLLAKKMNGYQRRIKNATEKM 820
K+E+LL + + Y QV + + S L K + + ++A +
Sbjct: 2811 LSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPS 2870
Query: 821 MALVAELSMKQALTI------ELQKEVREKEDFIFTCNSRIEKGLPLNKEIEK-----EW 869
+ S+K+A++ L KE++ + N I + PL ++++ +
Sbjct: 2871 TSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKA 2930
Query: 870 LKVLRDE----------EMHALAIAEKSQEFLE 892
+++++E E+H L + + S E E
Sbjct: 2931 FQIMQEELRQENLSWQHELHQLRMEKSSWEIHE 2963
Score = 94.0 bits (232), Expect = 6e-19
Identities = 205/951 (21%), Positives = 392/951 (41%), Gaps = 210/951 (22%)
Query: 89 LQNAKRFTEQIQQQQFHLQQADNFPEAFSTEVSKMREQLLKYQNEYNAVKEREFHNQYRL 148
LQ + E+I + Q+ F + E + + Q+ E ++E
Sbjct: 1839 LQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLN 1898
Query: 149 NSLKEE--KIIIVKEFEKITKPGEMEKKMKILRE------------STEELRKEIMQKKL 194
++EE ++ +KE + K E+ M L E + +++ E+++
Sbjct: 1899 QQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLES-- 1956
Query: 195 EIKNLRE---DLASKQKQLLKEQKELEELLGHQVVLKDEVAHHQTIPVQIGKEIEKITRK 251
E+KNL++ +L +++QL+KE+ ++E + + + K + A + KE++++ ++
Sbjct: 1957 EMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKE 2016
Query: 252 KVEMEKKKIVLEQEVKTLNDSLKKVENKVSAIVDEKENVIKEVEGKRALLEIKEREHNQL 311
K +QEVK L + + K+SA+ E +K LE + E
Sbjct: 2017 K----------QQEVKQLQKDCIRYQEKISAL----ERTVKA-------LEFVQTESQ-- 2053
Query: 312 VKLLELARENEATSLTERG-----------ILD-------------LNLRNSL-IDKQNY 346
K LE+ +EN A ++ R +LD L L+ L +K++
Sbjct: 2054 -KDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESV 2112
Query: 347 HDELSRKQREKERDFRNLRKMELLLKVSW----DALR----------------------Q 380
++ +K + ER + L K + DALR +
Sbjct: 2113 KSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKE 2172
Query: 381 TQALHQRL---LLEMEAIPKDDSTLSERRRELHKEVEVAKRNLAQQKIISEMESKLVEQQ 437
Q L + L + ++ A K S+L + R + ++ AK+ ++K ++SK E +
Sbjct: 2173 VQQLQENLDSTVTQLAAFTKSMSSLQDDR---DRVIDEAKK--WERKFSDAIQSKEEEIR 2227
Query: 438 LAEEN-KLLKEQ-----ENMKELVVNLLRMTQIKIDEKEQKSKDFLKAQQKYTNIVKEMK 491
L E+N +LK+Q +M+EL +N+ R+ K E K++ ++ QQK + +
Sbjct: 2228 LKEDNCSVLKDQLRQMSIHMEELKINISRLEHDK-QIWESKAQTEVQLQQKVCDTL---- 2282
Query: 492 AKDLEIRIHKKKKCEIYRRLREFAKLYDTIRNERNKFVNLLHKAHQKVNEIKERHKMSLN 551
+ + E+ +L E LY + +NE K + L ++ ++ +
Sbjct: 2283 ---------QGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKE 2333
Query: 552 ELEILRNSAVSQERKLQNSMLKHANNVTIRESMQNDV---RKIVSKLQE---MKEKKEAQ 605
+ L QE +QNS + E ++ D+ R++ S+L E MKE+K
Sbjct: 2334 QKGNLEGIIRQQEADIQNSKFSY-------EQLETDLQASRELTSRLHEEINMKEQKIIS 2386
Query: 606 L--------------------NNIDRLANTITMIEEEMVQLRKRYEKAVQHRNESGVQLI 645
L I L N ++ EEE + L + +KAV N QL+
Sbjct: 2387 LLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTN----QLM 2442
Query: 646 EREEEICIFYEKINIQEKMKLNGEIE----IHLLEEKIQFLKMKIAEKQRQICVTQKLLP 701
E + I +K NIQ+K +L+ ++ + ++I ++ E+ I + + L
Sbjct: 2443 ETLKTI----KKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLI 2498
Query: 702 AKRSLDADLAVLQIQFSQCTDRIKDLEKQFVKPDG------ENRARFLPGKDLTEKEM-- 753
+ + A+ L+ + + DL + K D E+ + + KD +K++
Sbjct: 2499 QEAA--AENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLE 2556
Query: 754 --IQKLDKLELQLAKKEEKLLEKDFIYEQVSRLTDRLCSKTQGCKQDTLLLAKKMNGYQR 811
+Q+ +LE + AK EEKL E + E + R + L Q KQD L+K++ +
Sbjct: 2557 VQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNAL----QEEKQD---LSKEIESLKV 2609
Query: 812 RIKNATEKMMALV---------AELSMKQ-------ALTIELQKEVREKEDFIFTCNSRI 855
I T ++ AL A+L +K+ AL QK + E E+ +
Sbjct: 2610 SISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEA 2669
Query: 856 EKGLPLNKEIEKEWLK-------VLRDE-EMHALAIAEKSQEFLEADNRQL 898
K + ++ K+ LK ++R+E E +AE +++ +E + + L
Sbjct: 2670 AKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLL 2720
Score = 81.6 bits (200), Expect = 3e-15
Identities = 195/998 (19%), Positives = 379/998 (37%), Gaps = 176/998 (17%)
Query: 82 QESEVQLLQNAKRFTEQIQQQQFHLQQADNFPEAFSTEVSKMREQLLKYQNEYNAVKERE 141
QE E+ L Q ++Q + L++ E F V +M + L N+ + ++
Sbjct: 1056 QEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEI 1115
Query: 142 FHNQYRLNSL--------KEEKIIIVKEFEKITKP---------GEMEKKMKILRESTEE 184
NQ + L + + +VKE I+ P E+E+K+ L + E+
Sbjct: 1116 SENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQ 1175
Query: 185 LRKEIMQK------------------KLEIKNLREDLASKQKQLLKEQKELE----ELLG 222
L+K++ + + E+K ++D Q+Q ++ KE E +L
Sbjct: 1176 LQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQ 1235
Query: 223 HQVVLKDEV---------------------------AHHQTIPV---------------- 239
Q+ +++ + H T PV
Sbjct: 1236 LQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDA 1295
Query: 240 ---QIGKEIEKITRKKVEMEKKKIVLEQEVKTLNDSLKKVENKVSAIVDEKENVIKEVEG 296
Q G + +I + E+E +K+ LE +V + L K +V + ++ E+E
Sbjct: 1296 SALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIES 1355
Query: 297 KRALLEIKEREHNQLVKLLELARENEATSLTERGILDLNLRNSLIDKQNYHDELSRKQRE 356
+K H V L ++ E++ L G+ L + Q DEL + +
Sbjct: 1356 ------LKTVSHEAEVHAESLQQKLESSQLQIAGLEHLR------ELQPKLDELQKLISK 1403
Query: 357 KERDFRNL-----RKMELLLKVSWDALRQT---QALHQRLLLEMEAIPKDDSTLSERRRE 408
KE D L K L K+ + + Q +ALH +L EM+A + D + + + E
Sbjct: 1404 KEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQL--EMQA-KEHDERIKQLQVE 1460
Query: 409 L----HKEVEVAKRNLAQQKIISEMESKLVEQQLA-EENKLLKEQENMKELVVNLLRMTQ 463
L K E+ + + A+Q+I ++++ L+ ++ A +ENK L+E+ ++ + R+T+
Sbjct: 1461 LCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIE--RLTK 1518
Query: 464 IKIDEKEQKSKDFLKAQQKYTNIVKEMKAKDLEIRIHKKKKCEIYRRLREFAKLYDTIRN 523
D + Q S AQ K + V A E R K E+ R L E L + +
Sbjct: 1519 SLADVESQVS-----AQNKEKDTVLGRLALLQEER--DKLITEMDRSLLENQSLSSSCES 1571
Query: 524 ERNKFVNLLHKAHQKVNEIKERHKMSLNELEILRNSAVSQERKLQNSMLKHANNVTIRES 583
+ L + V EI+ + E + +++ + + + N E
Sbjct: 1572 LKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAER 1631
Query: 584 MQNDVRKIVSKLQEMKEKKEAQLNNIDRLANTITMIEEEMVQLRKRYEKAVQHRNESGVQ 643
+Q+ V + + QE+ K + N + E+EM +++++ K + + + ++
Sbjct: 1632 IQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILE 1691
Query: 644 LIEREEEICIFYEKINIQEKMKLNGEIEIHL-LEEKIQFLKMKIAEKQRQICVTQKLLPA 702
L E + + K + + + ++E+++ +KM+ ++ Q L+
Sbjct: 1692 LEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKF---QSLMSE 1748
Query: 703 KRSLDADLAVLQIQFSQCTDRIKDLEKQFVKPDG-----ENRARFLPGKDLTEKEMIQKL 757
K SL ++ L+ Q + +LE K D E + +PG+ + +
Sbjct: 1749 KDSLSEEVQDLKHQIEGNVSKQANLEAT-EKHDNQTNVTEEGTQSIPGETEEQDSLSMST 1807
Query: 758 DKL---ELQLAKKEEKLLEKDF--------IYEQVSRLTDRLC---SKTQGCKQDTLLLA 803
+ AK + KDF +Q+ +L +R+ + Q K+ + L
Sbjct: 1808 RPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLE 1867
Query: 804 KKMNGYQRRIKNATEKMMALVAELSMKQALTIELQKEVREKEDFIFTCNSRIEKGLPLNK 863
+ N +I ++ L E++ L ++Q+E+ SR+ K K
Sbjct: 1868 NEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEEL-----------SRVTK----LK 1912
Query: 864 EIEKEWLKVLRDEEMHALA--------------IAEKSQEFLEADNRQLPNGVYTTAEQR 909
E +E L + M+ LA A+ E LE++ + L V E++
Sbjct: 1913 ETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEK 1972
Query: 910 PNAYIPEADATLPLPKPYGALAPFKPSEPGANMRHIRK 947
+ + K Y EPG N H ++
Sbjct: 1973 QQLVKEKTKVESEIRKEYLEKIQGAQKEPG-NKSHAKE 2009
Score = 78.2 bits (191), Expect = 3e-14
Identities = 165/818 (20%), Positives = 355/818 (43%), Gaps = 150/818 (18%)
Query: 77 AVMSTQESEVQLLQNAK---RFTEQIQQQQFHLQQADNFPEAFST--------EVSKMRE 125
+ + Q+ E QL Q +K +F ++ QQ +FP+ ++ ++ +++
Sbjct: 416 SAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQK 475
Query: 126 QLLKYQNEYNAVKEREFHNQYRLNSLKEEKIIIVKEF---EKITKPGEMEKKMK------ 176
++++ +NE A+ + L LK E + + E + GE ++++
Sbjct: 476 RVVELENEKGAL----LLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVD 531
Query: 177 ---------------ILRESTEELRKEIMQKKLEIKNLREDLASKQKQLLKEQKELEELL 221
+L + + KE+ LE+K +E++A + QL + K EE
Sbjct: 532 IANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQL--QGKRAEE-- 587
Query: 222 GHQVVLKDEVAHHQTIPVQIGKEIEKITRKKVEMEKKKIVLEQEVKTLNDSLKKVENKVS 281
A H+ + KE++++ + + K K+ LE +
Sbjct: 588 ----------ADHEVLD---QKEMKQMEGEGIAPIKMKVFLEDTGQDF------------ 622
Query: 282 AIVDEKENVIKEVEGKRALLEIKEREHNQLVKLLELARENEATSLTERGILDLNLRNSLI 341
++ +E+ + VE ++A EH +R +E SL + G+ L+++
Sbjct: 623 PLMPNEESSLPAVEKEQA-----STEHQ--------SRTSEEISLNDAGV---ELKSTKQ 666
Query: 342 DKQNYHDELSRKQREKERDFRNLRKMELLLKVSWDALRQTQALHQRLLLEMEAIPKDDST 401
D + + + + L+ L L++++ + Q ++++ L E K+ S
Sbjct: 667 DGDKSLSAVPDIGQCHQDELERLKSQILELELNF---HKAQEIYEKNLDEK---AKEISN 720
Query: 402 LSERRRELHKEVEVAKRNLAQQKIISEMESKLVEQQLAEENKLLKEQENMKELVVNLLRM 461
L++ E K A N + +SE +L+ Q+ E + + + + +K+L +NL
Sbjct: 721 LNQLIEEFKKN---ADNNSSAFTALSEERDQLL-SQVKELSMVTELRAQVKQLEMNLAEA 776
Query: 462 -TQIKIDEKEQKSKDFLKAQQKYTNIVKEMKAKDLEIRIHKKKKCEIYRRLREFAKLYDT 520
Q ++D + Q + D L +Q ++ + E K+KD++I + + + ++ + E + L +
Sbjct: 777 ERQRRLDYESQTAHDNLLTEQIHSLSI-EAKSKDVKIEVLQNELDDVQLQFSEQSTLIRS 835
Query: 521 IRNE-RNKFVNLLHKAHQ------KVNEIKERHKMSLNELEILRNSAVSQERKLQNSMLK 573
++++ +NK +L A + KV E+ + +S ELEI + + E+K L+
Sbjct: 836 LQSQLQNKESEVLEGAERVRHISSKVEELSQ--ALSQKELEITKMDQLLLEKKRDVETLQ 893
Query: 574 HANNVTIRESMQNDVRKIVSKLQEMKEKKEAQLNNIDRLANTITMIEEEMVQLRKRYEKA 633
TI E Q V+++ +K QLN +E + L R E+A
Sbjct: 894 Q----TIEEKDQQ-----VTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEA 944
Query: 634 VQHRNESGVQLIEREEEICIFYEKINIQEKMKLNGEIEIHLLEEKIQFLKMKIAEKQRQI 693
+ + +E + E+ ++ ++M G+I L+ + LK + +++R++
Sbjct: 945 KKEQ-------VEEDNEVSSGLKQ--NYDEMSPAGQISKEELQHEFDLLKKENEQRKRKL 995
Query: 694 CVT----QKLLPAKRSLDADLAVLQIQFSQCTDRIKDLEKQFVKPDGENRARFLPGKDLT 749
++LL L+ +LA L+ + S+ + + E+ V+ D EN K+ +
Sbjct: 996 QAALINRKELLQRVSRLEEELANLKDE-SKKEIPLSETERGEVEEDKEN-------KEYS 1047
Query: 750 EKEMIQKLDKLELQLAKKEEKLLEKDFIYEQVSR-LTDRLCSKTQGCKQDTLLLAKKMNG 808
EK + K ++E+ L ++ + EK+ + + + L ++L ++ Q L K+MN
Sbjct: 1048 EKCVTSKCQEIEIYL---KQTISEKEVELQHIRKDLEEKLAAEEQ-----FQALVKQMN- 1098
Query: 809 YQRRIKNATEKMMALVAELSMKQALTIELQKEVREKED 846
+ +++ T ++ L AE+S QA+ +QK + D
Sbjct: 1099 --QTLQDKTNQIDLLQAEISENQAI---IQKLITSNTD 1131
Score = 77.0 bits (188), Expect = 8e-14
Identities = 166/857 (19%), Positives = 355/857 (41%), Gaps = 142/857 (16%)
Query: 131 QNEYNAVKEREFHNQYRLNSLKEEKIIIVKEFEKITKPGEMEKKMKILRESTEELRKEIM 190
Q E A ++R NQ L++ E E T +E + + + E++ E+
Sbjct: 279 QQELTAAEQR---NQILSQQLQQ------MEAEHNTLRNTVETEREESKILLEKMELEVA 329
Query: 191 QKKLEIKNLRED---LASKQKQLLKEQKELEELLG-----HQVVLKDEVAHHQTIPVQIG 242
++KL NL+E+ L + +Q + Q ELE H+ ++++ +H ++ + G
Sbjct: 330 ERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQ-KTG 388
Query: 243 KEIE------KITRKKVEMEKKKIVLE--QEVKTLNDSLKKVENKVSAIVDE-------- 286
+E++ K K+ +K + ++ Q ++ L D L++ ++S ++
Sbjct: 389 QELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHET 448
Query: 287 -KENVIKEV--EGKRALLEIKEREHNQLVKLLELARENEATSLTERGILDLNLRNSLIDK 343
+ +V EG +A+ E E + +++EL E A L+ + +L N +
Sbjct: 449 ASQTSFPDVYNEGTQAVTE--ENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSS 506
Query: 344 QNYHDELSRKQREKERDFRNLRKMELLLKVSWDALRQTQALHQR-----------LLLEM 392
Q E + E +R+ + +++ K S A Q + + LLLEM
Sbjct: 507 QITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEM 566
Query: 393 EAIPKDDSTLSERRRELHKEVEVAKRNLAQQKIISEMES--------KLVEQQLAEENKL 444
+ ++ + L + + K E A + QK + +ME K+ + ++ L
Sbjct: 567 KEAQEEIAFLKLQLQ--GKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPL 624
Query: 445 LKEQENMKELVVNLLRMTQ---------------IKIDEKEQKSKDFLKA----QQKYTN 485
+ +E+ V T+ +++ +Q L A Q + +
Sbjct: 625 MPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQD 684
Query: 486 IVKEMKAKDLEIRIHKKKKCEIYRR---------------LREFAKLYDTIRNERNKFVN 530
++ +K++ LE+ ++ K EIY + + EF K D N + F
Sbjct: 685 ELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNAD---NNSSAFTA 741
Query: 531 LLHKAHQKVNEIKE-----RHKMSLNELEILRNSAVSQERKLQNSMLKHANNVTIRESMQ 585
L + Q ++++KE + + +LE+ A Q R S H N +T
Sbjct: 742 LSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLT------ 795
Query: 586 NDVRKIVSKLQEMKEKKEAQLNNIDRLANTITMIEEEMVQLRKRYEKAVQHRNESGVQLI 645
+ + L + K+ ++ + + + + E L + + +Q++ ++
Sbjct: 796 ----EQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGA 851
Query: 646 EREEEICIFYEKIN--IQEKMKLNGEIEIHLLEEK--IQFLKMKIAEKQRQI-----CVT 696
ER I E+++ + +K +++ LLE+K ++ L+ I EK +Q+ +T
Sbjct: 852 ERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMT 911
Query: 697 QKLL---PAKRSLDADLAVLQIQFSQCTDRIKDLEKQFVKPDGE-------NRARFLPGK 746
+K++ K SL ++ L+ Q + R ++ +K+ V+ D E N P
Sbjct: 912 EKMVQLNEEKFSLGVEIKTLKEQLN-LLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAG 970
Query: 747 DLTEKEMIQKLDKLELQLAKKEEK----LLEKDFIYEQVSRLTDRLCSKTQGCKQDTLLL 802
++++E+ + D L+ + +++ K L+ + + ++VSRL + L + K++ + L
Sbjct: 971 QISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKE-IPL 1029
Query: 803 AKKMNGYQRRIKNATEKMMALVAELSMKQALTIELQKEVREKEDFIFTCNSRIEKGLPLN 862
++ G K E V S Q + I L++ + EKE + +E+ L
Sbjct: 1030 SETERGEVEEDKENKEYSEKCVT--SKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAE 1087
Query: 863 KEIE---KEWLKVLRDE 876
++ + K+ + L+D+
Sbjct: 1088 EQFQALVKQMNQTLQDK 1104
Score = 76.6 bits (187), Expect = 1e-13
Identities = 154/842 (18%), Positives = 353/842 (41%), Gaps = 111/842 (13%)
Query: 85 EVQLLQNAKRFTEQIQQQQFHLQQADNFPEAFSTEVSKMREQLLKYQNEYNAVKE----- 139
E L + AK + Q + + ADN AF T +S+ R+QLL E + V E
Sbjct: 708 EKNLDEKAKEISNLNQLIEEFKKNADNNSSAF-TALSEERDQLLSQVKELSMVTELRAQV 766
Query: 140 -------REFHNQYRLN--SLKEEKIIIVKEFEKIT-KPGEMEKKMKILRESTEELRKEI 189
E Q RL+ S ++ ++ ++ + + K+++L+ ++++ +
Sbjct: 767 KQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQF 826
Query: 190 MQKKLEIKNLREDLASKQKQLLKEQKELEELLGHQVVLKDEVAHHQTIPVQIGKEIEKIT 249
++ I++L+ L +K+ ++L+ + + + L ++ KE+E
Sbjct: 827 SEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQ---------KELEITK 877
Query: 250 RKKVEMEKKKIVLEQEVKTLNDSLKKVENKVSAIVDEKENVIKEVEGKRALLEIKEREHN 309
++ +EKK+ +V+TL ++++ + +V+ I + ++ ++ L ++ +
Sbjct: 878 MDQLLLEKKR-----DVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLK 932
Query: 310 QLVKLLELARENEATSLTERGILDLNLRNSLIDKQNYHDELSRKQREKERDFRNLRKMEL 369
+ + LL A E + + E + L KQNY DE+S + + + ++ + +L
Sbjct: 933 EQLNLLSRAEEAKKEQVEEDNEVSSGL------KQNY-DEMSPAGQISKEELQH--EFDL 983
Query: 370 LLKVSWDALRQTQALHQRLLLEMEAIPKDDSTLSERRRELHKEV---EVAKRNLAQQKII 426
L K + R+ QA ++ + + + L+ + E KE+ E + + + K
Sbjct: 984 LKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKEN 1043
Query: 427 SEMESKLVEQQLAEENKLLKEQENMKELVVNLLRMTQIKIDEKEQKSKDFLKAQQKYTNI 486
E K V + E LK+ + KE+ + +R ++EK L A++++ +
Sbjct: 1044 KEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKD---LEEK-------LAAEEQFQAL 1093
Query: 487 VKEMKAKDLEIRIHKKKKCEIYRRLREFAKLYDTIRNERNKFVNLLHKAHQKVNEIKERH 546
VK+M + L++ D ++ E ++ ++ K + +
Sbjct: 1094 VKQMN-----------------QTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGD 1136
Query: 547 KMSLNELEIL-----RNSAVSQERKLQNSMLKHANNVTIRESMQNDVRKIVSKLQEMKEK 601
++L + ++ S+ + +L+ +L +++ + ++ KLQE
Sbjct: 1137 SVALVKETVVISPPCTGSSEHWKPELEEKIL----------ALEKEKEQLQKKLQEALTS 1186
Query: 602 KEAQLNNIDRLANTITMIEEEMVQLRKRYEKAVQHRNESGVQLIEREEEICIFYEKINIQ 661
++A L + EE+ Q + Y + + +E + E I ++ IQ
Sbjct: 1187 RKAILKKAQEKERHL---REELKQQKDDYNRLQEQFDEQS----KENENIGDQLRQLQIQ 1239
Query: 662 EKMKLNGEIEIHLLEEK------IQFLKMKIAEKQR-QICVTQKLLPAKRSLDADLAVLQ 714
+ ++G++ +E ++ K E+ Q + L P S D + LQ
Sbjct: 1240 VRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQ 1299
Query: 715 --IQFSQCTDRIKDLEKQFVKPDGENRARFLPGKDLTEKEMIQKLDKLELQLAKKEEKLL 772
+Q ++K++E + V+ + + + +LT+K +++ +L+ Q+ K+ ++
Sbjct: 1300 GGTSVAQIKAQLKEIEAEKVELELKVSSTT---SELTKKS--EEVFQLQEQINKQGLEIE 1354
Query: 773 EKDFIYEQVSRLTDRLCSKTQGCK------QDTLLLAKKMNGYQRRIKNATEKMMALVAE 826
+ + + L K + + + L K++ Q+ I E + L +
Sbjct: 1355 SLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQ 1414
Query: 827 LSMKQALTIELQKEVREKEDFIFTCNSRIEKGLPLNKEIEKEWLKVLRDEEMHALAIAEK 886
LS K+A ++Q E+ E+ED I ++++E + E K+ L + + I E+
Sbjct: 1415 LSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEE 1474
Query: 887 SQ 888
S+
Sbjct: 1475 SR 1476
Score = 70.5 bits (171), Expect = 7e-12
Identities = 142/743 (19%), Positives = 303/743 (40%), Gaps = 126/743 (16%)
Query: 8 TEKEEE----EEKDEKDQEPIYAIVPTIN-IQDERFVDLSETPAFIFLHELHAMGKLPGT 62
+++EEE EE+++K + ++ T+ I+ E ++ +F+ +M L
Sbjct: 2418 SQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFV-----KSMSSLQND 2472
Query: 63 RMAALKAKYTLLHDAVMSTQESEVQLLQNA----KRFTEQIQQQQFHLQQADNFPEAFST 118
R + Y L + +S + QL+Q A + E+I+ + H+ ++
Sbjct: 2473 R-DRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDA 2531
Query: 119 EVSKMRE--------------QLLKYQNEYNA------------VKEREFHNQ---YRLN 149
E+ + RE QLL+ Q + N +KE E N+ N
Sbjct: 2532 ELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFN 2591
Query: 150 SLKEEKIIIVKEFEKITKP-----------------GEMEKKMKILRESTEELRKEIMQK 192
+L+EEK + KE E + G ++K+ E L
Sbjct: 2592 ALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSS 2651
Query: 193 KLEIKNLREDLASKQKQLLKEQKELEELLGHQVVLKDEVAHHQTIPVQIGKE-IEKITRK 251
+ I L E+L QK+ K+ E+E+ L ++ A + +E + ++ R
Sbjct: 2652 QKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARD 2711
Query: 252 KVEMEKKKIVLEQEVKTLNDSLKKVENKVSAIVDEKENVIKEVEGKRALLEIKEREHNQL 311
VEME+K +++ +E K L ++ +S++ + +++ +E++ E+K + L
Sbjct: 2712 LVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELD------ELKRKYDASL 2765
Query: 312 VKLLELARENEATSLTERGILDLNLRNSLIDKQNYHDELSRKQREKERDFRNLRKMELLL 371
E L E+G+L+ R++L+ + + +E +L K+ L
Sbjct: 2766 ---------KELAQLKEQGLLNRE-RDALLSETAF-----SMNSTEENSLSHLEKLNQQL 2810
Query: 372 KVSWDALRQTQALHQRLLLEMEAIPKDDSTLSERRRELHKEVEVAKRNLAQQKIISEMES 431
+ L + + ++++ K ++L R L E+E K E
Sbjct: 2811 LSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELE---------KFRKSEEG 2861
Query: 432 KLVEQQLAEENKLLKEQENMKELVVNLLRMTQIKIDEKEQKSKDFLKAQQKYTNIVKEMK 491
K ++ A+ + E +++K+ + +L +++++ K+ QQ+Y I +E+
Sbjct: 2862 K--QRSAAQPSTSPAEVQSLKKAMSSLQ-------NDRDRLLKELKNLQQQYLQINQEI- 2911
Query: 492 AKDLEIRIHKKKKCEIYRRLREFAKLYDTIRNERNKFVNLLHKAHQKVNEIKERHKMSLN 551
E+ K + E + + F + + +R E + + LH+ + + E H+ +
Sbjct: 2912 ---TELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSS-WEIHERRMK 2967
Query: 552 ELEILRNSAVSQERKLQNSMLKHANNVTIRESMQNDVRKIVSKLQEMKEKKEAQLNNIDR 611
E ++ S Q+ L H N+ IRE + + K+Q ++ + D
Sbjct: 2968 EQYLMAISDKDQQ-------LSHLQNL-IRELRSSSSQTQPLKVQYQRQASPETSASPDG 3019
Query: 612 LANTI-------TMIEEEMVQLRKRYEKAVQHRNESGVQLIEREEEICIFY--EKINIQE 662
N + T + + + ++ ++ E +Q N + QL+E + + I +++E
Sbjct: 3020 SQNLVYETELLRTQLNDSLKEIHQK-ELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRE 3078
Query: 663 KMKLNGEIEIH--LLEEKIQFLK 683
+ G++ H +LE+++Q L+
Sbjct: 3079 NQQHYGDLLNHCAVLEKQVQELQ 3101
Score = 52.8 bits (125), Expect = 2e-06
Identities = 115/572 (20%), Positives = 215/572 (37%), Gaps = 108/572 (18%)
Query: 398 DDSTLSERRR----ELHKEVEVAKRNLAQQKIISEMESKLVEQQLAEENKLLKEQENMKE 453
DD T R ELH+E ++ N Q+ + + EQ + E ++++++ +
Sbjct: 19 DDDTDQNMRAPLDPELHQESDMEFNNTTQEDVQERLA--YAEQLVVELKDIIRQKDVQLQ 76
Query: 454 LVVNLLRMTQIKIDEKEQKSKDFLKAQQKYTNI---VKEMKAK-----------DLEIRI 499
L+ + D K +K K L A+ K T++ ++EMKA+ + ++
Sbjct: 77 QKDEALQEERKAADNKIKKLK--LHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSK 134
Query: 500 HKKKKCE-------IYRRLREFAKLYDTIR---------------NERNKFVNLLHKAHQ 537
H K E I +L+E +L T++ E +FV + + +
Sbjct: 135 HDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQE 194
Query: 538 KVNEIKE-RHKMSLNELEILRNSAV--------SQERKLQNSMLKHANNVTIRESMQNDV 588
K I + ++S + E V +Q R ++ +L+ + MQ +
Sbjct: 195 KEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKL 254
Query: 589 RKIVSKLQEMKEKKEAQLNNIDRLANTITMIEEEMVQLRKRYEKAVQHRNESGVQLIERE 648
R + KL+E +E + +D L +T E+ L ++ ++ N +
Sbjct: 255 RVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETER 314
Query: 649 EEICIFYEKINIQ---EKMKLNG--EIEIHLLEEKIQFLKMKIAEKQRQICVTQKLLPAK 703
EE I EK+ ++ K+ + E HLLE+ Q + + + R + QK
Sbjct: 315 EESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEM 374
Query: 704 RSLDADLAVLQI---QFSQCTDRIKDLEKQFVKPDGENRARFLPGKDLTEKEMIQKLDKL 760
+ + LQ + D +KD ++ L K+ + Q + +L
Sbjct: 375 EEKTSHILSLQKTGQELQSACDALKD-----------QNSKLLQDKNEQAVQSAQTIQQL 423
Query: 761 ELQLAKKEEKLLEKDFIYEQVSRLTDRLCSKTQGCKQDTLLLAKKMNGYQRRIKNATEKM 820
E QL +K + ++S+ +RL + + +T + Y + TE+
Sbjct: 424 EDQLQQKSK----------EISQFLNRLPLQ----QHETASQTSFPDVYNEGTQAVTEEN 469
Query: 821 MALVAELSMKQALTIELQKEVREKEDFIFTCNSRIEKGLPLNKEIEKEWLKVLRDEEMHA 880
+A LQK V E E+ EKG L IE E LK ++
Sbjct: 470 IA-------------SLQKRVVELEN---------EKGALLLSSIELEELKAENEKLSSQ 507
Query: 881 LAIAEKSQEFLEADNRQLPNGVYTTAEQRPNA 912
+ + E EAD + A +R ++
Sbjct: 508 ITLLEAQNRTGEADREVSEISIVDIANKRSSS 539
Score = 50.4 bits (119), Expect = 8e-06
Identities = 124/640 (19%), Positives = 250/640 (39%), Gaps = 106/640 (16%)
Query: 228 KDEVAHHQTIPVQIGKEIEKITRKKVEMEKKKIVLEQEVKTLNDSLKKVENKVSAIVDEK 287
+++V Q+ E++ I R+K + L+Q+ + L + K +NK+
Sbjct: 47 QEDVQERLAYAEQLVVELKDIIRQK------DVQLQQKDEALQEERKAADNKI------- 93
Query: 288 ENVIKEVEGKRALLEIKEREHNQLVKLLELARENEATSLTERGILDLNLRNSLIDKQNYH 347
K+ L K + L K +E + T L + L S DK +
Sbjct: 94 ---------KKLKLHAKAK-LTSLNKYIEEMKAQGGTVLPTEPQSEEQL--SKHDKSSTE 141
Query: 348 DELSRKQREKERDFRNLRKMELLLKVSWDALRQTQALH-QRLLLEMEAIPKDDSTLSERR 406
+E+ E E+ L++ E L+ L Q QA + EME L E+
Sbjct: 142 EEM-----EIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKE 196
Query: 407 R---ELHKEVEVAKRNLAQQKIISEMESKLVEQQLAEENKLLK--EQENMKELVVNLLRM 461
L ++ + A Q+++ E +++ Q E++LL+ Q +++ + LR+
Sbjct: 197 EFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRV 256
Query: 462 TQIKIDEKEQKSKDFLKAQQKYTNIVKEMKAKDLEIRIHKKKKCEIYRRLREFAKLYDTI 521
Q K++E E+ + Q + +E+ A + +I + ++ + E L +T+
Sbjct: 257 LQRKLEEHEE---SLVGRAQVVDLLQQELTAAEQRNQILSQ---QLQQMEAEHNTLRNTV 310
Query: 522 RNERNKFVNLLHKAHQKVNEIKERHKMSLNELEILRNSAVSQERKLQNSMLKHANNVTIR 581
ER + LL K +V E K+S + L+ + + Q + + + + +
Sbjct: 311 ETEREESKILLEKMELEVAE----RKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSAL 366
Query: 582 ESMQNDVRKIVSKLQEMKEKKEAQLNNIDRLANTITMIEEEMVQLRKRYEKAVQHRNESG 641
E Q+ K + E + ++I L T ++ L+ + K +Q +NE
Sbjct: 367 E-------------QKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQA 413
Query: 642 VQLIEREEEICIFYEKINIQEKMKLNGEIEIHLLEEKIQFLKMKIAEKQRQICVTQKLLP 701
VQ + IQ L+ ++ +K ++I LP
Sbjct: 414 VQ-------------------------------SAQTIQQLEDQLQQKSKEISQFLNRLP 442
Query: 702 AKRSLDADLAVLQIQFSQCT-----DRIKDLEKQFVKPDGENRARFLPGKDLTEKEMIQK 756
++ A +++ T + I L+K+ V+ + E A L +L E + +
Sbjct: 443 LQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENE 502
Query: 757 LDKLELQLAKKEEKLLEKDFIYEQVS--RLTDRLCSKTQGCKQDTL-----LLAKKMNGY 809
++ L + + + E D ++S + ++ S + QD L K+++
Sbjct: 503 KLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVL 562
Query: 810 QRRIKNATEKMMALVAELSMKQALTIEL----QKEVREKE 845
+K A E++ L +L K+A + QKE+++ E
Sbjct: 563 LLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQME 602
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 103 bits (256), Expect = 1e-21
Identities = 177/938 (18%), Positives = 388/938 (41%), Gaps = 140/938 (14%)
Query: 76 DAVMSTQESEVQLLQNAKRFTEQIQQQQFHLQQADNFPEAFSTEVSKMREQLLKYQNEYN 135
D V + +++V+L Q ++Q++ + ++ +E ++ +N+
Sbjct: 1015 DKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQ 1074
Query: 136 AVKEREFHNQYRLNSLKEEKIIIVKEFEKITKPGEMEKKMKILRESTEELRKEIMQKKL- 194
+ ER + LN+L +++ + + +++KK+K L+ EEL +E+ ++
Sbjct: 1075 QLDERLKKKDFELNALNAR----IEDEQALGS--QLQKKLKELQARIEELEEELEAERTA 1128
Query: 195 --EIKNLREDLA-------------------------SKQKQLLKEQKELEEL-LGHQVV 226
+++ LR DL+ ++ + K +++LEE L H+
Sbjct: 1129 RAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEAT 1188
Query: 227 LKDEVAHHQTIPVQIGKEIEKITRKKVEMEKKKIVLEQEVKTLNDSLKKVENKVSAIVDE 286
H ++G++I+ + R K ++EK+K + E+ + +++++ + +
Sbjct: 1189 AAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKM 1248
Query: 287 KENVIKEVEGKRALLEIKEREHNQLV-KLLELARENEATS--LTERGILDLNLRNSLIDK 343
+ ++ R+ E +R N L + +L EN S L E+ L L +
Sbjct: 1249 CRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTY 1308
Query: 344 QNYHDELSRKQREKERDFRNLRKMELLLKVSWDALRQTQALHQRLLLEMEAI-PKDDSTL 402
++L R+ E+ + L + D LR+ E++ + K +S +
Sbjct: 1309 TQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEV 1368
Query: 403 SERRRELH-------KEVEVAKRNLAQQKIISEMESKLVEQQLAEENKLLKEQEN-MKEL 454
++ R + +E+E AK+ LAQ+ +E + V + + K +N +++L
Sbjct: 1369 AQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDL 1428
Query: 455 VVNLLRMTQIKID-EKEQKSKDFLKAQ--QKYTNIVKEMKAKDLEIRIHKKKKCEIYRRL 511
+V++ R +K+Q++ D + A+ QKY E+++ E R + ++
Sbjct: 1429 MVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAY 1488
Query: 512 REFAKLYDTIRNERNKFVNLLHKAHQKVNEIKERHKMSLNELEILRNSAVSQERKLQNSM 571
E + +T + E NL + ++ K +++ELE +R +++ +LQ+++
Sbjct: 1489 EESLEHLETFKRENK---NLQEEISDLTEQLGSSGK-TIHELEKVRKQLEAEKMELQSAL 1544
Query: 572 ------LKHANNVTIRESMQ-NDV-----RKIVSKLQEMKEKKEAQLNNIDRLANTI--- 616
L+H +R ++ N + RK+ K +EM++ K L +D L ++
Sbjct: 1545 EEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAE 1604
Query: 617 TMIEEEMVQLRKRYEK-------AVQHRNESGVQLIEREEEICIFYEKINIQ--EKMKLN 667
T E ++++K+ E + H N + ++ + + + IQ + ++ N
Sbjct: 1605 TRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRAN 1664
Query: 668 GEIE--IHLLEEKIQFLKMKIAEKQRQICVTQK-------------------------LL 700
+++ I ++E + L+ ++ E + + T++ L+
Sbjct: 1665 DDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLI 1724
Query: 701 PAKRSLDADLAVLQIQFSQCTDRIKDLEK-------------QFVKPDGENRA---RFLP 744
K+ +DADL+ LQ + + ++ E+ + +K + + A R
Sbjct: 1725 NQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK 1784
Query: 745 GKDLTEKEMIQKLDKLELQLAKKEEKLLEKDFIYEQVSRLTDRLCSKTQGCKQDTLLLAK 804
+ T K++ +LD+ E K +K L+K + +V L + L ++ + + K
Sbjct: 1785 NMEQTIKDLQHRLDEAEQIALKGGKKQLQK--LEARVRELENELEAEQKRNAES----VK 1838
Query: 805 KMNGYQRRIKNATEKMMALVAELSMKQALTIELQKEV----REKEDFIFTCNSRIEKGLP 860
M +RRIK T + L Q L +LQ +V R+ E+ N+ + K
Sbjct: 1839 GMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRK 1898
Query: 861 LNKEIEKEWLKVLRDEEMHALAIAEKSQEFLEADNRQL 898
+ E+ DE IAE L A +R +
Sbjct: 1899 VQHEL---------DEAEERADIAESQVNKLRAKSRDI 1927
Score = 87.0 bits (214), Expect = 7e-17
Identities = 172/947 (18%), Positives = 391/947 (41%), Gaps = 128/947 (13%)
Query: 67 LKAKYTLLHDAVMSTQESEVQLLQNAKRFTEQ-------IQQQQFHLQQADNFPEAFSTE 119
L+AK +++ + +E +L ++ ++ I + L + + A +
Sbjct: 915 LEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENK 974
Query: 120 VSKMREQLL-------KYQNEYNAVKEREFH-------NQYRLNSLKEEKIIIVKEFEKI 165
V + E++ K E A++E + ++N+L + K+ + ++ + +
Sbjct: 975 VKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDL 1034
Query: 166 TKPGEMEKKMKI-LRESTEELRKEIMQKKLEIKNLREDLASKQKQLLKEQKEL------- 217
E EKK+++ L + +L ++ + I +L D ++L K+ EL
Sbjct: 1035 EGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARI 1094
Query: 218 --EELLGHQVVLKDEVAHHQTIPVQIGKEIEKITRKKVEMEKKKIVLEQEVKTLNDSLKK 275
E+ LG Q L+ ++ Q ++ +E+E + ++EK + L +E++ +++ L++
Sbjct: 1095 EDEQALGSQ--LQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEE 1152
Query: 276 VENKVSAIVDEKENVIKEVEGKRALLEIKEREHNQLVKLLELARENEATSLTERGILDLN 335
S ++ + E + R LE +H L R+ A S+ E G N
Sbjct: 1153 AGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAAL---RKKHADSVAELGEQIDN 1209
Query: 336 LRNSLIDKQNYHDELSRKQREKERDFRNLRKMELLLKVSWDALRQTQALHQRL---LLEM 392
L+ KQ E S + E + N ME ++K + + + L ++ +
Sbjct: 1210 LQRV---KQKLEKEKSEFKLELDDVTSN---MEQIIKAKANLEKMCRTLEDQMNEHRSKA 1263
Query: 393 EAIPKDDSTLSERRRELHKEVEVAKRNLAQQK-IISEM-ESKLV-EQQLAEENKLLKEQE 449
E + + L+ +R +L E R L +++ +IS++ KL QQL + + L+E+
Sbjct: 1264 EETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEV 1323
Query: 450 NMKELVVNLLRMTQIKIDEKEQKSKDFLKAQQKYTNIVKEMKAKDLEIRIH--------- 500
K + + L+ + D ++ ++ +A+ + ++ + ++ + R
Sbjct: 1324 KAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRT 1383
Query: 501 ---KKKKCEIYRRLREFAKLYDTIRNERNKFVNLLHKAHQKVNEIKERHKMSLNELEILR 557
++ K ++ +RL+E + + + + + H+ ++ ++ + S L
Sbjct: 1384 EELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALD 1443
Query: 558 NSAVSQERKLQNSMLKHANNVTIRESMQNDVRKIVSKLQEMKEKKEAQLNNIDRLANTIT 617
+ ++ L K+ + + ES Q + R + ++L ++K E L +++
Sbjct: 1444 KKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENK 1503
Query: 618 MIEEEMVQLRKRY---EKAVQHRNESGVQLIEREEEICIFYEK----INIQEKMKLNGEI 670
++EE+ L ++ K + + QL + E+ E+ + +E L ++
Sbjct: 1504 NLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQL 1563
Query: 671 EIHLLEEKIQFLKMKIAEKQRQICVTQK----------------------LLPAKRSLDA 708
E + ++ +I+ K+AEK ++ ++ L K+ ++
Sbjct: 1564 EFNQIKAEIE---RKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEG 1620
Query: 709 DLAVLQIQFSQCTDRIKDLEKQF-----------VKPDGENRARFLPGKDLTEKEMIQKL 757
DL ++IQ S + +KQ ++ D RA +++ E L
Sbjct: 1621 DLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNL 1680
Query: 758 DKLEL-------QLAKKEEKLLEKDFI--YEQVSRLTDR---LCSKTQGCKQDTLLLAKK 805
+ EL + ++ KL E++ I E+V L + L ++ + D L +
Sbjct: 1681 LQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTE 1740
Query: 806 MNGYQRRIKNATEKMMALVAELSMKQALTIELQKEVREKEDFIFTCNSRIEKGLPLNKEI 865
+ + +NA EK + + +M + +E+++++D ++ +E+ ++
Sbjct: 1741 VEEAVQECRNAEEKAKKAITDAAM-------MAEELKKEQD----TSAHLERMKKNMEQT 1789
Query: 866 EKEWLKVLRDEEMHALAIAEKSQEFLEADNRQLPNGVYTTAEQRPNA 912
K+ L + E AL +K + LEA R+L N + AEQ+ NA
Sbjct: 1790 IKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENEL--EAEQKRNA 1834
Score = 81.3 bits (199), Expect = 4e-15
Identities = 153/773 (19%), Positives = 326/773 (42%), Gaps = 107/773 (13%)
Query: 174 KMKILRESTEELRKEIMQKKLEIKNLREDLASKQKQLLKEQKELEELLGHQVVLKDEVAH 233
K+K L +S E KE+ K E L+E L + + + ++++ LL + L+ +V
Sbjct: 835 KIKPLLKSAER-EKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQA 893
Query: 234 HQTIPVQIGKEIEKITRKKVEMEKKKIVLEQEVKTLNDSLKKVENKVSAIVDEKENVIKE 293
Q + +++ + K+++E K VK +N+ L +++E + E
Sbjct: 894 EQDNLADAEERCDQLIKNKIQLEAK-------VKEMNERL-----------EDEEEMNAE 935
Query: 294 VEGKRALLEIKEREHNQLVKLLELARENEATSLTERGILDLNLRNSLIDKQNYHDELSRK 353
+ K+ LE + S +R I DL L + ++K+ + E K
Sbjct: 936 LTAKKRKLE-------------------DECSELKRDIDDLELTLAKVEKEKHATENKVK 976
Query: 354 QREKERDFRNLRKMELLLKVSWDALRQTQALHQRLLLEMEAIPKDDSTLSERRRELHKEV 413
+E + E++ K++ + + Q HQ+ L +++A +TL++ + +L ++V
Sbjct: 977 NLTEEMAGLD----EIIAKLTKEK-KALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQV 1031
Query: 414 EVAKRNLAQQKIISEMESKLVEQQLAEENKLLKEQ----ENMKELVVNLLRMTQIKIDEK 469
+ + +L Q+K + M+ + +++L + KL +E EN K+ + L+ +++
Sbjct: 1032 DDLEGSLEQEKKV-RMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNAL 1090
Query: 470 EQKSKDFLKAQQKYTNIVKEMKAKDLEIRIHKKKKCEIYRRLR-EFAKLYDTIRNERNKF 528
+ +D + +KE++A+ E+ +++ E R R + KL + E +
Sbjct: 1091 NARIEDEQALGSQLQKKLKELQARIEEL----EEELEAERTARAKVEKLRSDLSRELEEI 1146
Query: 529 VNLLHKAHQKVNEIKERHKMSLNELEILRNSAVSQERKLQNSMLKH-ANNVTIRESMQND 587
L +A + E +K E + +R R L+ + L+H A +R+ +
Sbjct: 1147 SERLEEAGGATSVQIEMNKKREAEFQKMR-------RDLEEATLQHEATAAALRKKHADS 1199
Query: 588 VRKI---VSKLQEMKEKKEAQLNNIDRLANTITMIEEEMVQLRKRYEKAVQHRNESGVQL 644
V ++ + LQ +K+K E + + + +T E++++ + EK + + +
Sbjct: 1200 VAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEH 1259
Query: 645 IEREEEICIFYEKINIQEKMKL---NGEIEIHLLEEKI---QFLKMKIAEKQR------- 691
+ EE + Q + KL NGE+ L E++ Q + K+ Q+
Sbjct: 1260 RSKAEETQRSVNDLTSQ-RAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQ 1318
Query: 692 ---QICVTQKLLPAKRSLDADLAVLQIQFSQCTDRIKDLEKQFVKPDGENRARFLPGKDL 748
++ L A +S D +L+ Q+ + T+ +L++ K + E +
Sbjct: 1319 LEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSE----VAQWRTK 1374
Query: 749 TEKEMIQKLDKLELQLAKKEEKLLEKDFIYEQVS---RLTDRLCSKTQGCKQDTLLLAKK 805
E + IQ+ ++LE K ++L E + E V+ ++ + Q +D ++ ++
Sbjct: 1375 YETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVER 1434
Query: 806 MNGYQRRIKNATEKMMALVAELSMK----QALTIELQKEVREKEDFIFTCNSRIEKGLP- 860
N + ++AE K Q+ QKE R +F + E+ L
Sbjct: 1435 SNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEH 1494
Query: 861 ------LNKEIEKEWLKVLRD-----EEMHALAIAEKSQEFLEADNRQLPNGV 902
NK +++E + + +H L EK ++ LEA+ +L + +
Sbjct: 1495 LETFKRENKNLQEEISDLTEQLGSSGKTIHEL---EKVRKQLEAEKMELQSAL 1544
Score = 70.5 bits (171), Expect = 7e-12
Identities = 112/534 (20%), Positives = 229/534 (42%), Gaps = 73/534 (13%)
Query: 64 MAALKAKYTLLHDAVMSTQESEVQLLQNAKRFTEQIQQQQFHLQQADNFPEAFSTEVSKM 123
+A K KY + S+Q+ L + ++ HL+ + E+S +
Sbjct: 1453 LAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDL 1512
Query: 124 REQLLKYQNEYNAVKEREFHNQYRLNSLKEEKIIIVKEFEKITKPGEMEKKMKILRESTE 183
EQL + H + EK+ E EK+ E++ ++ S E
Sbjct: 1513 TEQL--------GSSGKTIH--------ELEKVRKQLEAEKM----ELQSALEEAEASLE 1552
Query: 184 ELRKEIMQKKLEIKNLREDLASKQKQLLKEQKELEELLGHQVVLKDEVAHHQTIPVQIGK 243
+I++ +LE ++ ++ +++L ++ +E+E+ + + + D +Q
Sbjct: 1553 HEEGKILRAQLEFNQIKAEI---ERKLAEKDEEMEQAKRNHLRVVDS--------LQTSL 1601
Query: 244 EIEKITRKKVEMEKKKIVLEQEVKTLNDSLKKVENKVSAIVDEKENVIKEVEGKRALLEI 303
+ E +R + KKK + L ++E ++S K+V+ ++LL+
Sbjct: 1602 DAETRSRNEALRVKKK---------MEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKD 1652
Query: 304 KEREHNQLVKLLELARENEATSLTERGILDLNLRNSLIDKQNYHDELSRKQREKERDFRN 363
+ + + V+ + +EN A + ER RN+L+ Q +EL + ER R
Sbjct: 1653 TQIQLDDAVRANDDLKENIA--IVER-------RNNLL--QAELEELRAVVEQTERS-RK 1700
Query: 364 LRKMELLLKVSWDALRQTQALHQRLLLEMEAIPKDDSTLSERRRELHKEVEVAKRNLAQQ 423
L + EL+ + + Q LH + + K D+ LS+ + E+ + V+ RN ++
Sbjct: 1701 LAEQELI-----ETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQEC-RNAEEK 1754
Query: 424 KIISEMESKLVEQQLAEENKLLKEQENMKELVVNLLRMTQIKIDEKEQKS-KDFLKAQQK 482
+ ++ ++ ++L +E E MK+ + ++ Q ++DE EQ + K K QK
Sbjct: 1755 AKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQK 1814
Query: 483 YTNIVKEMKAKDLEIRIHKKKKCEIYRRLREFAK-----LYDTIRNERN--KFVNLLHKA 535
V+E+ + E+ +K+ E + +R+ + Y T + +N + +L+ K
Sbjct: 1815 LEARVREL---ENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKL 1871
Query: 536 HQKVNEIKERHKMSLNELEILRNSAVSQERKLQNSMLKHANNVTIRESMQNDVR 589
KV + +K E E N+ +S+ RK+Q+ + + I ES N +R
Sbjct: 1872 QLKV----KAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLR 1921
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 102 bits (254), Expect = 2e-21
Identities = 198/916 (21%), Positives = 377/916 (41%), Gaps = 178/916 (19%)
Query: 82 QESEVQLLQNAKRFTEQIQQQQFHLQQADNFPEAFSTEVSKMREQLLKYQNEYNAVKERE 141
+E V LLQ Q+Q +Q +L A+ + +QL+K + + A K +E
Sbjct: 876 EEKMVSLLQEKNDLQLQVQAEQDNLNDAE-----------ERCDQLIKNKIQLEA-KVKE 923
Query: 142 FHNQYRLNSLKEEKIIIVKEFEKI-TKPGEMEKKMKILRESTEELRKEIMQKKLEIKNLR 200
+ RL +E + + K+ + E++K + L + ++ KE + ++KNL
Sbjct: 924 MNE--RLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLT 981
Query: 201 EDLASKQK---QLLKEQKELEELLGHQVVLKDEVAHHQTIPVQIGKEIEKITRKKVEMEK 257
E++A + +L KE+K L+E HQ L D +Q+ ++ K + K
Sbjct: 982 EEMAGLDEIIAKLTKEKKALQE--AHQQALDD---------LQVEED------KVNSLSK 1024
Query: 258 KKIVLEQEVKTLNDSLKKVENKVSAIVDEKENVIKEVEGKRALLE--IKEREHNQLVKLL 315
K+ LEQ+V L SL++ E KV + E +++EG L + I + E+++L +L
Sbjct: 1025 SKVKLEQQVDDLEGSLEQ-EKKVRM---DLERAKRKLEGDLKLTQESIMDLENDKL-QLE 1079
Query: 316 ELARENEATSLTERGILDLNLRNSLI-DKQNYHDELSRKQREKERDFRNLRKMELLLKVS 374
E ++ E D+N +NS I D+Q +L +K +E + + ++E L+
Sbjct: 1080 EKLKKKE---------FDINQQNSKIEDEQVLALQLQKKLKENQ---ARIEELEEELEAE 1127
Query: 375 WDALRQTQALHQRLLLEMEAIPKDDSTLSERRRELHKEVEVAKRNLAQ-QKIISEMESKL 433
A + + L L E+E I L E ++E+ K+ A+ QK+ ++E
Sbjct: 1128 RTARAKVEKLRSDLSRELEEI---SERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEAT 1184
Query: 434 VEQQLAEENKLLKEQENMKELVVNLLRMTQIKIDEKEQKSKDFLKAQQKYTNIVKEMKAK 493
++ + K +++ EL + + ++K +++KS+ L+ +N+ + +KAK
Sbjct: 1185 LQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAK 1244
Query: 494 ----------DLEIRIHKKKKCEIYRRLREFAKLYDTIRNERNKFVNLLHKAHQKVNEIK 543
+ + ++ K E R L +F ++ E + L + ++++
Sbjct: 1245 ANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLT 1304
Query: 544 ERHKMSLNELEILRNSAVSQERKLQNSMLKHANNVTIRESMQNDVRKIVSKLQEMKEKKE 603
++E L+ + +E K +N+ L HA +S ++D + + +E E K
Sbjct: 1305 RGKLSYTQQMEDLKRQ-LEEEGKAKNA-LAHA-----LQSARHDCDLLREQYEEETEAK- 1356
Query: 604 AQLNNIDRLANTITMIEEEMVQLRKRYEKAVQHRNES--------GVQLIEREEEICIFY 655
A+L + AN+ E+ Q R +YE R E +L + EE +
Sbjct: 1357 AELQRVLSKANS------EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVN 1410
Query: 656 EKINIQEKMK--LNGEIEIHLLEEK-------------------IQFLKMKIAEKQRQIC 694
K + EK K L EIE +++ + + K K E Q ++
Sbjct: 1411 AKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELE 1470
Query: 695 VTQKLLPAKRSLDADLAVLQIQFSQCTDRIKDLEKQFVKPDGE----NRARFLPGKDLTE 750
+QK RSL +L L+ + + + ++ +++ E GK++ E
Sbjct: 1471 SSQK---EARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHE 1527
Query: 751 KEMIQK---LDKLELQLAKK---------------------------EEKLLEKDFIYEQ 780
E ++K ++KLELQ A + E KL EKD EQ
Sbjct: 1528 LEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQ 1587
Query: 781 VSRLTDRLCSKTQ-------GCKQDTLLLAKKMNGYQRRIKNATEKMMALVAELSMKQAL 833
R R+ Q + + L + KKM G + + +LS +
Sbjct: 1588 AKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEG----------DLNEMEIQLSHANRM 1637
Query: 834 TIELQKEVREKEDFIFTCNSRIEKGLPLNKEIEKEWLKVLRDEEMHALAIAEKSQEFLEA 893
E QK+V+ + + +++ + N ++++ +AI E+ L+A
Sbjct: 1638 AAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKEN------------IAIVERRNNLLQA 1685
Query: 894 DNRQLPNGVYTTAEQR 909
+ +L V T R
Sbjct: 1686 ELEELRAVVEQTERSR 1701
Score = 88.6 bits (218), Expect = 3e-17
Identities = 168/944 (17%), Positives = 397/944 (42%), Gaps = 122/944 (12%)
Query: 67 LKAKYTLLHDAVMSTQESEVQLLQNAKRFTEQ-------IQQQQFHLQQADNFPEAFSTE 119
L+AK +++ + +E +L ++ ++ I + L + + A +
Sbjct: 917 LEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENK 976
Query: 120 VSKMREQLL-------KYQNEYNAVKEREFH-------NQYRLNSLKEEKIIIVKEFEKI 165
V + E++ K E A++E + ++NSL + K+ + ++ + +
Sbjct: 977 VKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDL 1036
Query: 166 TKPGEMEKKMKILRESTEE--------LRKEIMQKKLEIKNLREDLASKQKQLLKEQKEL 217
E EKK+++ E + ++ IM + + L E L K+ + ++ ++
Sbjct: 1037 EGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKI 1096
Query: 218 EELLGHQVVLKDEVAHHQTIPVQIGKEIEKITRKKVEMEKKKIVLEQEVKTLNDSLKKVE 277
E+ + L+ ++ +Q ++ +E+E + ++EK + L +E++ +++ L++
Sbjct: 1097 EDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAG 1156
Query: 278 NKVSAIVDEKENVIKEVEGKRALLEIKEREHNQLVKLLELARENEATSLTERGILDLNLR 337
S ++ + E + R LE +H L R+ A S+ E G NL+
Sbjct: 1157 GATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAAL---RKKHADSVAELGEQIDNLQ 1213
Query: 338 NSLIDKQNYHDELSRKQREKERDFRNLRKMELLLKVSWDALRQT---QALHQRLLLEMEA 394
KQ E S + E + N+ ++ + K + + + +T QA R+ LE
Sbjct: 1214 RV---KQKLEKEKSEFKLELDDVTSNMEQI-IKAKANLEKVSRTLEDQANEYRVKLEEAQ 1269
Query: 395 IPKDDSTLSERRRELHKEVEVAKRNLAQQKIISEM-ESKL-VEQQLAEENKLLKEQENMK 452
+D T ++R + + E+A++ ++ +IS++ KL QQ+ + + L+E+ K
Sbjct: 1270 RSLNDFT-TQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAK 1328
Query: 453 ELVVNLLRMTQIKIDEKEQKSKDFLKAQQKYTNIVKEMKAKDLEIRIH------------ 500
+ + L+ + D ++ ++ +A+ + ++ + ++ + R
Sbjct: 1329 NALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEEL 1388
Query: 501 KKKKCEIYRRLREFAKLYDTIRNERNKFVNLLHKAHQKVNEIKERHKMSLNELEILRNSA 560
++ K ++ +RL++ + + + + + H+ ++ ++ + S L
Sbjct: 1389 EEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQ 1448
Query: 561 VSQERKLQNSMLKHANNVTIRESMQNDVRKIVSKLQEMKEKKEAQLNNID-------RLA 613
+ ++ L K+ + + ES Q + R + ++L ++K E L +++ L
Sbjct: 1449 RNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQ 1508
Query: 614 NTITMIEEEMVQLRKRYEKAVQHRNESGVQLIEREEEICIFYEKINIQEKMKLNGEIEIH 673
I+ + E++ + K + + R + V+ +E + + + +E L ++E +
Sbjct: 1509 EEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFN 1568
Query: 674 LLEEKIQFLKMKIAEK-----------QRQICVTQ-----------KLLPAKRSLDADLA 711
++ +I+ K+AEK QR + Q ++L K+ ++ DL
Sbjct: 1569 QIKAEIE---RKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLN 1625
Query: 712 VLQIQFSQCTDRIKDLEKQF-----------VKPDGENRARFLPGKDLTEKEMIQKLDKL 760
++IQ S + +KQ ++ D RA +++ E L +
Sbjct: 1626 EMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQA 1685
Query: 761 EL-------QLAKKEEKLLEKDFI--YEQVSRLTDR---LCSKTQGCKQDTLLLAKKMNG 808
EL + ++ KL E++ I E+V L + L ++ + + D L ++
Sbjct: 1686 ELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEE 1745
Query: 809 YQRRIKNATEKMMALVAELSMKQALTIELQKEVREKEDFIFTCNSRIEKGLPLNKEIEKE 868
+ +NA EK + + +M + +E+++++D ++ +E+ ++ K+
Sbjct: 1746 AVQECRNAEEKAKKAITDAAM-------MAEELKKEQD----TSAHLERMKKNMEQTIKD 1794
Query: 869 WLKVLRDEEMHALAIAEKSQEFLEADNRQLPNGVYTTAEQRPNA 912
L + E AL +K + LEA R+L + AEQ+ NA
Sbjct: 1795 LQHRLDEAEQIALKGGKKQLQKLEARVRELEGEL--EAEQKRNA 1836
Score = 87.8 bits (216), Expect = 4e-17
Identities = 152/710 (21%), Positives = 310/710 (43%), Gaps = 90/710 (12%)
Query: 206 KQKQLLKEQKELEELLGHQVVLKDEVAHHQTIPVQIGKEIEKITRKKVEMEKKKIVLEQE 265
K K LLK + +E+ +K+E +I + +EK ++ E+E+K + L QE
Sbjct: 837 KIKPLLKSAETEKEM----ATMKEEFG-------RIKETLEKSEARRKELEEKMVSLLQE 885
Query: 266 -------VKTLNDSLKKVENKVSAIVDEKENVIKEVEGKRALLEIKEREHNQLVKLLELA 318
V+ D+L E + ++ K + +V+ LE E E N + +
Sbjct: 886 KNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMNERLE-DEEEMNAELTAKKRK 944
Query: 319 RENEATSLTERGILDLNLRNSLIDKQNYHDELSRKQREKERDFRNLRKMELLLKVSWDAL 378
E+E + L ++ I DL L + ++K+ + E K +E + E++ K++ +
Sbjct: 945 LEDECSEL-KKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLD----EIIAKLTKEK- 998
Query: 379 RQTQALHQRLLLEMEAIPKDDSTLSERRRELHKEVEVAKRNLAQQKIISEMESKLVEQQL 438
+ Q HQ+ L +++ ++LS+ + +L ++V+ + +L Q+K + M+ + +++L
Sbjct: 999 KALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKV-RMDLERAKRKL 1057
Query: 439 AEENKLLKEQENMKELVVNLLRMTQIKIDEKEQKSKDFLKAQQKYTNIVKEMKAKDLEIR 498
+ KL QE++ +L + L++ E++ K K+F Q+ + I E + L ++
Sbjct: 1058 EGDLKL--TQESIMDLENDKLQL------EEKLKKKEF-DINQQNSKIEDE---QVLALQ 1105
Query: 499 IHKKKKCEIYRRLREFAKLYDTIRNERNKFVNLLHKAHQKVNEIKERHKMS--LNELEIL 556
+ KK K E R+ E + + R R K L +++ EI ER + + ++I
Sbjct: 1106 LQKKLK-ENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIE 1164
Query: 557 RNSAVSQE-----RKLQNSMLKH-ANNVTIRESMQNDVRKI---VSKLQEMKEKKEAQLN 607
N E R L+ + L+H A +R+ + V ++ + LQ +K+K E + +
Sbjct: 1165 MNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKS 1224
Query: 608 NIDRLANTITMIEEEMVQLRKRYEKAVQ----HRNESGVQLIEREEEICIF-YEKINIQE 662
+ +T E++++ + EK + NE V+L E + + F ++ +Q
Sbjct: 1225 EFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQT 1284
Query: 663 KMKLNGEIEIHLLEEKIQFLKMKIAEKQRQICVTQKLLPAKRSLDA-------------- 708
+ NGE+ LEEK + K + TQ++ KR L+
Sbjct: 1285 E---NGEL-ARQLEEKEALISQLTRGK---LSYTQQMEDLKRQLEEEGKAKNALAHALQS 1337
Query: 709 ---DLAVLQIQFSQCTDRIKDLEKQFVKPDGENRARFLPGKDLTEKEMIQKLDKLELQLA 765
D +L+ Q+ + T+ +L++ K + E + E + IQ+ ++LE
Sbjct: 1338 ARHDCDLLREQYEEETEAKAELQRVLSKANSE----VAQWRTKYETDAIQRTEELEEAKK 1393
Query: 766 KKEEKLLEKDFIYEQVS---RLTDRLCSKTQGCKQDTLLLAKKMNGYQRRIKNATEKMMA 822
K ++L + + E V+ ++ + Q +D ++ ++ N +
Sbjct: 1394 KLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDK 1453
Query: 823 LVAELSMK----QALTIELQKEVREKEDFIFTCNSRIEKGLPLNKEIEKE 868
++AE K Q+ QKE R +F + E+ L + ++E
Sbjct: 1454 ILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRE 1503
Score = 86.7 bits (213), Expect = 1e-16
Identities = 134/639 (20%), Positives = 275/639 (43%), Gaps = 87/639 (13%)
Query: 7 DTEKEEEEEKDEKDQ--EPIYAIVPTINIQDERFVDLSETPAFIFLHELHAMGKLPGTRM 64
D +++ EEE K+ + + ++ E++ + +E A EL + + +
Sbjct: 1316 DLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKA-----ELQRVLSKANSEV 1370
Query: 65 AALKAKYTLLHDAVMSTQESEVQLLQNAKRFTEQIQQQQFHLQQADNFPEAFSTEVSKMR 124
A + KY DA+ T+E L+ AK+ Q LQ A+ EA + + S +
Sbjct: 1371 AQWRTKYET--DAIQRTEE-----LEEAKKKLAQ------RLQDAEEAVEAVNAKCSSLE 1417
Query: 125 EQLLKYQNEYNAVKEREFHNQYRLNSLKEEKIIIVKEFEKIT---------KPGEMEKKM 175
+ + QNE + + +L +++ + F+KI E+E
Sbjct: 1418 KTKHRLQNEIEDLMVDVERSNAAAAALDKKQ----RNFDKILAEWKQKYEESQSELESSQ 1473
Query: 176 KILRESTEELRK----------EIMQKKLEIKNLREDLASKQKQLLKEQKELEELLGHQV 225
K R + EL K + K E KNL+E+++ +QL + K + EL +
Sbjct: 1474 KEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRK 1533
Query: 226 VLKDEVAHHQTIPVQIGKEIE----KITRKKVEMEKKKIVLEQEVKTLNDSLKKVENKVS 281
L+ E Q+ + +E KI R ++E + K +E+++ ++ +++ +
Sbjct: 1534 QLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQ 1593
Query: 282 AIVDEKENVIK-EVEGKRALLEIKEREHNQLVKL-LELARENEATSLTERGILDLNLRNS 339
+VD + + E + +L +K++ L ++ ++L+ N + ++ + +L++
Sbjct: 1594 RVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVK--SLQSL 1651
Query: 340 LIDKQNYHDELSRKQREKERDFRNLRKMELLLKVSWDALRQT--QALHQRLLLEMEAIPK 397
L D Q D+ R + + + + + LL+ + LR Q R L E E I
Sbjct: 1652 LKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIET 1711
Query: 398 DD----------STLSERRR------ELHKEVEVAK---RNLAQQKIISEMESKLVEQQL 438
+ S ++++++ +L EVE A RN ++ + ++ ++ ++L
Sbjct: 1712 SERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEEL 1771
Query: 439 AEENKLLKEQENMKELVVNLLRMTQIKIDEKEQKS-KDFLKAQQKYTNIVKEMKAKDLEI 497
+E E MK+ + ++ Q ++DE EQ + K K QK V+E++ E+
Sbjct: 1772 KKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEG---EL 1828
Query: 498 RIHKKKKCEIYRRLREFAK-----LYDTIRNERN--KFVNLLHKAHQKVNEIKERHKMSL 550
+K+ E + +R+ + Y T +++N + +L+ K KV + +K
Sbjct: 1829 EAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKV----KAYKRQA 1884
Query: 551 NELEILRNSAVSQERKLQNSMLKHANNVTIRESMQNDVR 589
E E N+ +S+ RK+Q+ + + I ES N +R
Sbjct: 1885 EEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLR 1923
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 101 bits (251), Expect = 4e-21
Identities = 173/845 (20%), Positives = 355/845 (42%), Gaps = 77/845 (9%)
Query: 76 DAVMSTQESEVQLLQNAKRFTEQIQQQQFHLQQADNFPEAFSTEVSKMREQLLKYQNEYN 135
D M E + +Q + E + +++ +L + + + E+ + RE+L Q E
Sbjct: 578 DGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELR 637
Query: 136 AVKEREFHNQYRLNSLKEEKIIIVKEFEKITKPGE-MEKKMKILRESTEELRKEIMQKKL 194
++R Q ++ + +E E+ + E +E K +L + E+R+ + + L
Sbjct: 638 RQRDRLEEEQ---EDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATL 694
Query: 195 EIKNLREDLASKQKQLLKEQKELEELLGHQVVLKDEVAHHQTIPVQIGKEIEKITRKKVE 254
+ L+ + A + L K + EL L+ E A Q ++ E + + K++
Sbjct: 695 QRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLD 754
Query: 255 MEKKKIVLEQEVKTLNDSLKKVENKVSAIVDEKENVIK---EVEGKRALLEIKEREHNQL 311
+ + LE+E L ++ E + + +E+E + + E E R LE R Q
Sbjct: 755 LNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQA 814
Query: 312 VKLLELARENEATSLTERGILDLNLRNSLIDKQNYHDELSRKQREKERDFRNLRKMELLL 371
+ LE + T ER L L EL + +RE +R L +
Sbjct: 815 QEALE---QQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALER----- 866
Query: 372 KVSWDALRQTQAL---HQRLLLEMEAIPKDDSTLSERRRELHKEVEVAKRNLAQ-QKIIS 427
A R+ +AL H L +++ A ++ TLSE L E E + +L + Q+ ++
Sbjct: 867 -----AAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLA 921
Query: 428 EMESKLVEQQLAEENKLLKEQENMKELVVNLLRM---TQIKID-EKEQKSKDFLKAQQKY 483
++E++ EQ AE LL +E + + L + TQ K +KE ++ ++A+++
Sbjct: 922 QLEARR-EQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREA 980
Query: 484 TNIVKEMKA---KDLEIRIHKKKKCEIYRRLREFAKLYDTIRNERNKFVNLLHKAHQKVN 540
++E +A +DL+ R+ ++K+ E A+L ++ E+ + + L ++++
Sbjct: 981 QASLREQRAAHEEDLQ-RLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELS 1039
Query: 541 EIKERHKMSLNELEILRNSAVSQERKLQNSMLKHANNVTIRESMQNDVRKIVSKLQEMKE 600
E +++ + E +++ K Q LK + + E + + + EM+
Sbjct: 1040 E-----EIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMER 1094
Query: 601 KKEAQLNNIDRLANTITMIEEEMVQLR-KRYEKAVQHRNESGVQLIEREEEICIFYEKIN 659
+K + ++ +T+ + E+ LR +R E A H E V+ ++ +
Sbjct: 1095 QKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQE--VRRLQEQARDLGKQRDSC 1152
Query: 660 IQEKMKLNGEIEIHLLEEKIQFLKMKIAEKQRQICVTQKLLPAKRSLDADLAVLQIQFSQ 719
++E +L ++ LLE+ L+ ++ E QR++ +Q+ +R
Sbjct: 1153 LREAEEL--RTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQR--------------- 1195
Query: 720 CTDRIKDLEKQFVKPDGENRARFLPGKDLTEKEMIQKLDKLELQLAK--KEEKLLEKDFI 777
+L + + E A ++L + +++ L+LA KE+KL +
Sbjct: 1196 --QEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEA 1253
Query: 778 YEQVSRLTDRLCSKTQGCKQDTLLLAKKMNGYQRRIKNATEKMMAL---VAELSMKQALT 834
V + L + Q ++ L +++ +R++K + L +AEL + AL
Sbjct: 1254 RTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALG 1313
Query: 835 IELQKEVREKEDFIFTCNSRIEKGLPLNKEIEKEWLKVLRDE-EMHALAIAEKSQEFLEA 893
+KE R + R+ KG + L+V+R E ++ + E+ EF
Sbjct: 1314 ERAEKESRRE---TLGLRQRLLKG--------EASLEVMRQELQVAQRKLQEQEGEFRTR 1362
Query: 894 DNRQL 898
+ R L
Sbjct: 1363 ERRLL 1367
Score = 60.1 bits (144), Expect = 1e-08
Identities = 177/915 (19%), Positives = 369/915 (40%), Gaps = 120/915 (13%)
Query: 59 LPGTRMAAL----------KAKYTLLHDAVMSTQESEVQLLQNAKRFTEQIQQQQFHLQQ 108
LP T MA+L + + + + D + ++ +L +E+++Q L+
Sbjct: 68 LPATEMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQA-LRLEP 126
Query: 109 AD---NFPEAFSTEVSKMREQLLKYQNEYNAVKEREFHNQYRLNSLKEEKIIIVKEFEKI 165
+ P + ++R QL + Q Y + Q R L + + +++K
Sbjct: 127 GELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKK- 185
Query: 166 TKPGEMEKKMKILRESTEELRKEIMQKKLEIKNLREDLASKQKQLLKEQKELEELLGHQV 225
+ E+E+++ E E+ Q++L +DL S +L +EQ+ L
Sbjct: 186 -RCSELEQQLL-------ERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNA 237
Query: 226 VLKDEVAHHQTIPVQIGKEIEKI----TRKKVEMEKKKIVLEQEVKTLNDSLKKVENKVS 281
+L++++ + + ++I K+ TR + E+E ++ +E ++ N +++
Sbjct: 238 MLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLL 297
Query: 282 AIVDEKENVIKEVEGKRALL-EIKEREHNQLVKL-LELARENEATSLTERGILDLNLRNS 339
+ ++V G R L+ E+K L++L ELAR + A G L LR
Sbjct: 298 LL-------WRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLG-LSTGLR-- 347
Query: 340 LIDKQNYHDELSRKQREKERDFRNLRKMELLLKVSWDALRQTQALHQRLLLEMEAIPKDD 399
L+ + E + + L + +L ++ LR+ Q++ ++ D
Sbjct: 348 ----------LAESRAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDL-----DK 392
Query: 400 STLSERRRELHKEVE-VAKRNLAQQKIISEMESKL-VEQQLAEENKLLKEQENMKELVVN 457
+ LS R EL V+ + K+NL + ++ ++ KL + L + + E E+ + L
Sbjct: 393 ADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQT 452
Query: 458 LLRMTQIKIDEKEQKSKDFLKAQQKYTNIVKEMKAKDLEIRIHKKKKCEIYRRLREFAKL 517
L + Q + + E + L ++ + R + R R +
Sbjct: 453 LRDLAQAVLSDSESGVQ--LSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRG 510
Query: 518 YDTIRNERNKFV---NLLHKAHQKVNEIKERHKMSLNELEILR---NSAVSQERKLQNSM 571
++ + + LHK +V +++ R++ S + L LR + + S+ R L+ +
Sbjct: 511 PSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQL 570
Query: 572 LKHANNVTIRESMQNDVRKIVSKLQEMKEKKEAQLNNIDRLANTITMIEEEMVQLRKRYE 631
+ + D ++ V +L+ E + +N LA+++ + +++ +LR+ E
Sbjct: 571 QRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSN---LAHSLQVAQQQAEELRQERE 627
Query: 632 KAVQHRNESGVQLIEREEEICIFYEKINIQEKMKLNGEIE-----IHLLEEKIQFLKMKI 686
K + E Q EEE ++ +Q+ ++ E+E + LE K L ++
Sbjct: 628 KLQAAQEELRRQRDRLEEE-----QEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKEL 682
Query: 687 AE---------KQRQICVTQKLLPAKRSLDADLAVLQIQFSQCTDRIKD--LEKQFVKPD 735
E QR + +K A+ A+ ++++ S R ++ L+ K
Sbjct: 683 VEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLS 742
Query: 736 GENRARFLPGKDLT--------EKEMI---QKLDKLELQLAKKEEKLLEKDFIYEQVSRL 784
N + DL EK + Q+ + E +A++E++ LE+ + ++V+R
Sbjct: 743 ALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQ 802
Query: 785 ----TDRLCSKTQ-GCKQDTLLLAKKMNGYQRRIKNATEKMMALVAELSM----KQALTI 835
+ R+ + Q +Q L + + Q ++ + ++ EL Q
Sbjct: 803 GLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVE 862
Query: 836 ELQKEVREKE-------DFIFTCNSRIEKGLPLNKE-----IEKEWLKVLRDEEMHALAI 883
L++ REKE + +G L++E +EKE L+ E LA
Sbjct: 863 ALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQ 922
Query: 884 AEKSQEFLEADNRQL 898
E +E LEA+ + L
Sbjct: 923 LEARREQLEAEGQAL 937
Score = 52.0 bits (123), Expect = 3e-06
Identities = 109/539 (20%), Positives = 225/539 (41%), Gaps = 90/539 (16%)
Query: 376 DALR-QTQALHQRLLLEMEAIPKDDSTLSERRRELHKEVEVAKRNLAQQKIISEMESKLV 434
D LR QT AL+ R L EMEA +D +T R R+L K VA+ A++ + +
Sbjct: 1526 DELRTQTSALN-RQLAEMEA-ERDSAT--SRARQLQK--AVAESEEARRSVDGRLSGVQA 1579
Query: 435 EQQLAEENKLLKEQENMKELVVNLLRMTQIKIDEKE-QKSKDFLKAQQKYTNIVKEMKAK 493
E L EE+ E+E L Q+ E+ Q ++ L+A Q+ + +MKA
Sbjct: 1580 ELALQEESVRRSERERRATL-------DQVATLERSLQATESELRASQEK---ISKMKAN 1629
Query: 494 DLEIRIHKKKKCEIYRRLREFAKLYDTIRNERNKFVNLLHKAHQKVNEIKERHKMSLNEL 553
+ ++ K+ ++ E+ + + +L
Sbjct: 1630 ETKLEGDKR-----------------------------------RLKEVLDASESRTVKL 1654
Query: 554 EILRNSAVSQERKLQNSMLKHANNVTIRESMQNDVRKIVSKLQEMKEKKEAQLNNIDRLA 613
E+ R S E +LQ S L ++ +++Q+ V + ++ + + K ++RL
Sbjct: 1655 ELQRRSL---EGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLN 1711
Query: 614 NTITMIEEEMVQLRKRYEKAVQHRNESGVQLIEREEEICIFYEKINIQEKMKLNGEIEIH 673
+ +EE LR + + +S L + + +++Q+ + E +
Sbjct: 1712 GALAKVEESEGALRDKVRGLTEALAQSSASLNSTRD------KNLHLQKALTA-CEHDRQ 1764
Query: 674 LLEEKIQFLKMKIAEKQRQICVTQKLLPAKRSLDADLAVLQIQFSQCTDRIKDLEKQFVK 733
+L+E++ + ++E ++Q + + R ADL + +++ +++++ +Q +
Sbjct: 1765 VLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQ--R 1822
Query: 734 PDGENRARFLPGKDLTEKEMIQ-KLDKLELQLAKKEEK---------LLEKDFIYEQVSR 783
+GE A K E+ ++Q +L L+ LA+ E + LEKD + + R
Sbjct: 1823 QEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRV--ALRR 1880
Query: 784 LTDRLCSKTQGCKQDTLLLAKKMNGYQRRIKNATEKMMALVAELSMKQALTIELQKEVRE 843
D++ + +DT+ L+ + R + A ++ ++ +A + L++
Sbjct: 1881 TLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSP 1940
Query: 844 KEDFIFTCNSRIEKGLPLNKEIEKEWLKVLRDEEMHALAIAEKSQEFLEADNRQLPNGV 902
+ + ++E L +E+E+ LR A A E++ E E +RQ G+
Sbjct: 1941 AQLEVDAQQQQLE----LQQEVER-----LRS----AQAQTERTLEARERAHRQRVRGL 1986
Score = 51.6 bits (122), Expect = 3e-06
Identities = 154/854 (18%), Positives = 321/854 (37%), Gaps = 113/854 (13%)
Query: 82 QESEVQLLQNAKRFTEQIQQQQFHLQQADNFPEAFSTEVSKMREQLLKYQNEYNAVKERE 141
++ Q + A +++++ Q + ++ E ++R QL ++ + ++
Sbjct: 1118 RDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRREL 1177
Query: 142 FHNQYRLNSLKEEKIIIVKEFEKITKP-GEMEKKMKILRESTEELRKEIMQKKLEIKNLR 200
Q +L +E + + +E ++ + GE K+ + LR S EELR + KK E + +
Sbjct: 1178 LEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAV--KKAESERIS 1235
Query: 201 EDLASKQKQLLKEQKELEELLGHQVVLKDEVAHHQTIPVQIGKEIEKITRKKVEMEKKKI 260
LA++ K EQK + L +E +GKE ++ E+E+ ++
Sbjct: 1236 LKLANEDK----EQK---------LALLEEAR------TAVGKEAGELRTGLQEVERSRL 1276
Query: 261 VLEQEVKTLNDSLKKVENKVSAIVDEKENVIKEVEGKRALLEIKERE-HNQLVKLLELAR 319
+E++ L +K ++++ + + E + E++G+ AL E E+E + + L +
Sbjct: 1277 EARRELQELRRQMKMLDSENTRLGRE----LAELQGRLALGERAEKESRRETLGLRQRLL 1332
Query: 320 ENEATSLTERGILDLNLRNSLIDKQNYHDELSRKQREKERDFRNLRKMELLLKVSWDALR 379
+ EA+ R L + RK +E+E +FR + L
Sbjct: 1333 KGEASLEVMRQELQV---------------AQRKLQEQEGEFRTRERRLLGSLEEARGTE 1377
Query: 380 QTQALHQR-LLLEMEAIPKDDSTLSERRRELHKEVEVAKRNLAQQKIISEMESKLVEQQL 438
+ Q H R L L++EA + + L R + + LA+ E++ + E QL
Sbjct: 1378 KQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARV----EVQRRAAEAQL 1433
Query: 439 AEENKLLKEQENM--------KELVVNLLRMTQIKIDEKEQKSKDFLK----AQQKYTNI 486
L+ + + + + R + + S L+ +Q
Sbjct: 1434 GGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGP 1493
Query: 487 VKEMKAKDLEIRIHKKKKCEIYRRLREFAKLYDTIRN--------------ERNKFVNLL 532
+ DL+ + E + LR + D +R ER+ +
Sbjct: 1494 ATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRA 1553
Query: 533 HKAHQKVNEIKERHKMSLNELEILRNSAVSQERKLQNSMLKHANNV----TIRESMQ--- 585
+ + V E +E + L ++ QE ++ S + + T+ S+Q
Sbjct: 1554 RQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATE 1613
Query: 586 NDVRKIVSKLQEMKEKKEAQLNNIDRLANTITMIEEEMVQLRKRYEKAVQHRNESGVQLI 645
+++R K+ +MK + + RL + E V+L + S + L
Sbjct: 1614 SELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLS 1673
Query: 646 EREEEICIFYEKINIQEKMKLNGEIEIHLLEEKIQFLKMKIAEKQRQICVTQKLLPAKRS 705
+RE + ++++ ++ + E++ L+ ++ L +A+ + L R
Sbjct: 1674 DREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEES---EGALRDKVRG 1730
Query: 706 LDADLAVLQIQFSQCTDRIKDLEKQFVKPDGENRARFLPGKDLTEKEMIQKLDKLELQLA 765
L LA + D+ L+K + + + + ++LD L+
Sbjct: 1731 LTEALAQSSASLNSTRDKNLHLQKALTACEHDRQV------------LQERLDAARQALS 1778
Query: 766 KKEEKLLEKDFIYEQVSRLTDRLCS------KTQGCKQDTLLLAKKMNGYQRRIKNATEK 819
+ + + + EQV L + + +G Q + ++ + N +K
Sbjct: 1779 EARK---QSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQK 1835
Query: 820 MM----ALVAELSMKQALTIELQKEVREKEDFIFTCNSRIEKG-LPLNKEIEKEWLKVLR 874
+ L L Q +L+ E RE E R+EK + L + ++K + LR
Sbjct: 1836 LQDERRLLQERLGSLQRALAQLEAEKREVERSAL----RLEKDRVALRRTLDKVEREKLR 1891
Query: 875 DEEMHALAIAEKSQ 888
E AEK +
Sbjct: 1892 SHEDTVRLSAEKGR 1905
Score = 48.1 bits (113), Expect = 4e-05
Identities = 71/358 (19%), Positives = 137/358 (38%), Gaps = 35/358 (9%)
Query: 68 KAKYTLLHDAVMSTQESEVQLLQNAKRFTEQIQQQQFHLQQADNFPEAFSTEVSKMREQL 127
+A+ L D V S Q A +++ L + + A +V + E L
Sbjct: 1676 EAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEAL 1735
Query: 128 LKYQNEYNAVKEREFHNQYRLNSLKEEKIIIVKEFEKITKP-GEMEKKMKILRESTEELR 186
+ N+ +++ H Q L + + ++ ++ + + + E K+ L E + LR
Sbjct: 1736 AQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLR 1795
Query: 187 KEIMQKKLEIKNLREDLASKQKQLLKEQKELEELLGHQVVLKDEVAHHQTIPVQIGKEIE 246
E+ +L+ L ++ L + Q+ L L+DE Q + + +
Sbjct: 1796 GEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALA 1855
Query: 247 KITRKKVEMEKKKIVLEQEVKTLNDSLKKVENKVSAIVDEKENVIKEVEGKRALLEIKER 306
++ +K E+E+ + LE++ L +L KVE + K R
Sbjct: 1856 QLEAEKREVERSALRLEKDRVALRRTLDKVERE------------------------KLR 1891
Query: 307 EHNQLVKL-LELARENEATSLTERGILDLNLRNSLIDKQNYHDELSRKQREKERDFRNLR 365
H V+L E R + + E + + + ++ Q E S + E D +
Sbjct: 1892 SHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVD---AQ 1948
Query: 366 KMELLLKVSWDALRQTQALHQRLLLEMEAIPKDDSTLSERRRELHKEVEVAKRNLAQQ 423
+ +L L+ + LR QA +R L E + +R R L ++V K L Q+
Sbjct: 1949 QQQLELQQEVERLRSAQAQTERTLEARERAHR------QRVRGLEEQVSTLKGQLQQE 2000
Score = 38.5 bits (88), Expect = 0.030
Identities = 87/440 (19%), Positives = 195/440 (44%), Gaps = 61/440 (13%)
Query: 414 EVAKRNLAQQKI-----ISEMESKLVEQQLAEENKLLKEQENMKELVVNLLRMTQIKIDE 468
E+ RNL+Q + +EM S L L EEN+LL+++ + E +LL ++ + DE
Sbjct: 53 EIVTRNLSQPESPVLLPATEMASLL---SLQEENQLLQQELSRVE---DLLAQSRAERDE 106
Query: 469 KEQKSKDFLKAQQKYTNIVKEMKAKDLEIRIHKKKKCEIYRRLRE----FAKLYDTIRNE 524
K + ++ + + + + E R ++ E+ R+L+E + + +
Sbjct: 107 LAIKYNAVSERLEQALRL-EPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEG 165
Query: 525 RNKFVNLLHKAHQKVNEIKERHKMSLNELEILRNSAVSQERKLQNSMLKHANNVTIRESM 584
+ + L+ + K+ + K+R S E ++L S ++++L+++ +H+
Sbjct: 166 QQRQAQLVQRLQGKILQYKKR--CSELEQQLLERSGELEQQRLRDT--EHSQ-------- 213
Query: 585 QNDVRKIVSKLQEMKEKKE--AQLN-----NIDRLANTITMIEEEMVQLRK---RYEKAV 634
D+ + +L+E +++ AQ+N +D+ + + E++ ++ R K +
Sbjct: 214 --DLESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKEL 271
Query: 635 QHRNESGVQLIEREEEICIFYEKINIQEKMKLNGEIE--IHLLEEKIQFLKMKIAEKQRQ 692
+HR + REEE Y + L ++ L+ E F + + + +
Sbjct: 272 EHREAAW----RREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGE 327
Query: 693 ICVTQKLLP-AKRSLDADLAVLQIQFSQCTDRIKDLEKQFVKPDGENRARFLPGKDLTEK 751
+ T + + A L L + + + ++ L+ Q + + R + L KDL ++
Sbjct: 328 LARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQL---EEQLRDKVLREKDLAQQ 384
Query: 752 EMIQKLDK-------LELQLAKK--EEKLLEKDFIYEQVSRLTDRLCSKTQGCKQDTLLL 802
+M LDK EL LA K E++ LEKD + + ++ + L ++ ++ L
Sbjct: 385 QMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEAL--ESLRLQEQAALE 442
Query: 803 AKKMNGYQRRIKNATEKMMA 822
+ G Q+ +++ + +++
Sbjct: 443 TEDGEGLQQTLRDLAQAVLS 462
>gi|118498356 kinectin 1 isoform a [Homo sapiens]
Length = 1357
Score = 100 bits (250), Expect = 5e-21
Identities = 174/900 (19%), Positives = 376/900 (41%), Gaps = 139/900 (15%)
Query: 67 LKAKYTLLHDAVMSTQESEVQLLQNAKRFTEQIQQQQFHLQQADNFPEAFSTEVSKMREQ 126
L++K+ + V S L + ++ +++ Q Q+ N E+ +V + EQ
Sbjct: 518 LQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQ 577
Query: 127 LLKYQNEYNAVKEREFHNQYRLNSLKEEKIIIVKEFEKITKPGEMEKKMKILRESTEELR 186
NE + ++FH+Q + +L EEL
Sbjct: 578 -----NEALKAQIQQFHSQIAAQT-----------------------SASVL---AEELH 606
Query: 187 KEIMQKKLEIKNLREDLASKQKQLLKEQKELEELLGHQVVLKDEVAHHQTI---PVQIGK 243
K I +K +IK + LAS++ +L +++EL+++ +LK EV Q +
Sbjct: 607 KVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAH 666
Query: 244 EIEKITRKKVEMEKKKIVLE-----------QEVKTLND---SLKKVENKVSAIVDEKEN 289
E+EK+ + + K +LE +E K LND +LK K+ +V E+ N
Sbjct: 667 ELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPN 726
Query: 290 VIKEVEGKRALLEIKEREHNQLVKLLELARENEATSLTERGILDLNLRNSLIDKQNYHDE 349
VE ++ K+ + + +LLE AT E + + NS + K+ +
Sbjct: 727 K-DVVEQMEKCIQEKDEKLKTVEELLETGLIQVATK--EEELNAIRTENSSLTKE--VQD 781
Query: 350 LSRKQREKERDFRNLRKMELLLKVSWDALRQTQALHQRLLLEMEAIPKDDSTLSERRREL 409
L KQ + + F +L +E L KV + + +++ + L E+ + + T+ ++L
Sbjct: 782 LKAKQND-QVSFASL--VEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTV----QDL 834
Query: 410 HKEVEVAKRNLAQQKIISEMESKLVEQQLAEENKLLKEQENMKELVVNLLRMTQIKIDEK 469
+E++ K + ++ + + + +N L ++E M + + ++EK
Sbjct: 835 KQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTM--------KAVLEEK 886
Query: 470 EQKSKDFLKAQQKYTNIVKEMKAKDLEIRIHKKKKCEIYRRLREFAKLYDTIRNERNKFV 529
E+ + K Q + +KA E+ H K+ + E + NE +
Sbjct: 887 EKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLE 946
Query: 530 NLLHKAH-------QKVNEIKERHKMSLNELEILRNSAVSQERKLQNSMLKHANNVTIRE 582
+L + Q + ++++ +K+ +++E L+ Q + +S H + +
Sbjct: 947 AMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLK----QQNYQQASSFPPHEELLKVIS 1002
Query: 583 SMQNDVRKIVSKLQEMKEKKEAQ--LNN---------IDRLANTITMIEEEMVQLRKRYE 631
+ ++ + ++L +K+ E Q NN ++ LA+T M+++++ + K +
Sbjct: 1003 EREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQ 1062
Query: 632 KAVQHRNESGVQLIEREEEICIFYEKINIQEKMK------------------LNGEIEIH 673
+ V+ V+L E +E + + K+++ + +G E+
Sbjct: 1063 QQVE-----AVEL-EAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVK 1116
Query: 674 LLEEKIQ-------FLKMKIAEKQRQICVTQKLL-PAKRSLDADLAVLQIQFSQCTDRIK 725
+LE K++ L+++ + + + T+ +L +RS++ + +++ + IK
Sbjct: 1117 VLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIK 1176
Query: 726 DLEKQFVKPDGENRARFLPGKDL----TEKEMIQ-KLDKLELQLAKKEEKLLE-KDFIYE 779
++ F + E KD+ E+E ++ +L+K E++ + ++ E KD + E
Sbjct: 1177 QMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTE 1236
Query: 780 QVSRLTDRLCSKTQGCKQDTLLLAKKMNGYQRRIKNATEKMMALVAEL-SMKQALTIELQ 838
+L D S+ ++ LL ++N +++ + + +L +Q+L +
Sbjct: 1237 LQKKLDDSY-SEAVRQNEELNLLKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQS 1295
Query: 839 KEVREKEDFIFTCNSRIEKGLPLNKEIEKEWLKVLRDEEMHALAIAEKSQEFLEADNRQL 898
K V+ D NS + P + EKE + V ++ + L Q+ L+A N+QL
Sbjct: 1296 KIVKAAGDTTVIENSDVS---PETESSEKETMSVSLNQTVTQL------QQLLQAVNQQL 1346
Score = 95.5 bits (236), Expect = 2e-19
Identities = 174/915 (19%), Positives = 365/915 (39%), Gaps = 169/915 (18%)
Query: 63 RMAALKAKYTLLHDAVMSTQESEVQLLQNAKRFTEQIQQQQFHLQQADNFPEAFSTEVSK 122
R+ L+ ++ + + + + + Q+ ++ EQ++ + HL+Q +
Sbjct: 379 RIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGI---------- 428
Query: 123 MREQLLKYQNEYNAVKEREFHNQYRLNSLKEEKIIIVKEFEKITKPGEMEKKMKILREST 182
+R+ + N+ + + E LN L+++ +V E L E T
Sbjct: 429 LRDAVSNTTNQLESKQSAE------LNKLRQDYARLVNE----------------LTEKT 466
Query: 183 EELRKEIMQKKLEIKNLREDLASKQKQLLKEQKELEELLGHQVVLKDEVAHHQTIP---- 238
+L++E +QK KN + + QL + ++ EE+ Q ++ A H+
Sbjct: 467 GKLQQEEVQK----KNAEQAATQLKVQLQEAERRWEEV---QSYIRKRTAEHEAAQQDLQ 519
Query: 239 ---VQIGKEIEKITRKKVEMEKKKIVLEQEVKTLNDSLKKVENKVSAIVDEKENVIKEVE 295
V E++ + K + K LEQ + L +S +K NK ++ + ++++++ E
Sbjct: 520 SKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNE 579
Query: 296 GKRALLEIKEREHNQLVKLLELARENEATSLTERGILDLNLRNSLIDKQNYHDELSRKQR 355
+A + ++ H+Q +A + A+ L E + ++ I KQ S + R
Sbjct: 580 ALKAQI---QQFHSQ------IAAQTSASVLAEELHKVIAEKDKQI-KQTEDSLASERDR 629
Query: 356 --EKERDFRNLRKMELLLKVSWDALR-----QTQALHQRLLLEMEAIPKDD--------- 399
KE + ++++ M LLK L+ Q A H+ ++ KDD
Sbjct: 630 LTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQL 689
Query: 400 ----STLSERRRELHKEVEVAKRNLAQ-QKIISEMESKLVEQQLAEENKLLKEQENMKEL 454
S E + L+ + + K + + Q ++SE +K V +Q+ K ++E++ +
Sbjct: 690 QHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQM---EKCIQEKDEKLKT 746
Query: 455 VVNLLRMTQIKIDEKEQKSKDFLKAQQKYTNIVKEMKAKDLEIRIHKKKKCEIYRRLREF 514
V LL I++ KE++ T V+++KAK + F
Sbjct: 747 VEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQND--------------QVSF 792
Query: 515 AKLYDTIRNERNKFVNLLHKAHQKVNEIKERHKMSLNELEILRNSAVSQERKLQNSMLK- 573
A L + ++ ++H+ K+ ++E + L L++ Q+ K + LK
Sbjct: 793 ASLVEELK-------KVIHEKDGKIKSVEELLEAEL--LKVANKEKTVQDLKQEIKALKE 843
Query: 574 HANNVTIRESMQNDVRKIVSKLQEMKEKKEAQLNNIDR--------LANT---ITMIEEE 622
NV + ++ Q + V +LQ + + KE Q+N + LANT + ++EE
Sbjct: 844 EIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEE 903
Query: 623 MVQLRKRYEKAVQHRNESGVQLIEREEEICIFYEKIN---------------IQEKMKLN 667
L+ ++ QH + + EE + EK N + K +L
Sbjct: 904 NESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLL 963
Query: 668 GEI--EIHLLEEKIQFLKMKIAEKQRQICVTQKLLPAKRSLDADLAVLQIQFSQCTDRIK 725
++ E L + +I+ LK + ++ ++LL + +++ L + D ++
Sbjct: 964 QDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVE 1023
Query: 726 DLEKQFVKPDGENRARFLPGKDLTEK--EMIQKLDKLELQLAKK-----EEKLLEKDFIY 778
K+ DL EK E ++ L E L K +E+ + + +
Sbjct: 1024 HQRKK--------------NNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVE 1069
Query: 779 EQVSRLTDRLCSKTQGCKQDTLLLAKKMNGYQRRIK------NATEKMMALVAELSMKQA 832
+ + +L K L + ++G++++ K + +E++ L +L
Sbjct: 1070 LEAKEVLKKLFPKVS--VPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADE 1127
Query: 833 LTIELQKEVREKEDFIFTCNSRIEKGLPLNKEIEKEWLKVLRDEE-------MHALAIAE 885
+ LQ E + + + ++K ++ E +W KV DE + +E
Sbjct: 1128 MHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKW-KVKVDESHKTIKQMQSSFTSSE 1186
Query: 886 KSQEFLEADNRQLPN 900
+ E L ++N+ + N
Sbjct: 1187 QELERLRSENKDIEN 1201
Score = 90.1 bits (222), Expect = 9e-18
Identities = 163/810 (20%), Positives = 341/810 (42%), Gaps = 114/810 (14%)
Query: 67 LKAKYTLLHDAVMSTQESEVQLLQNAKRFTEQIQQQQFHLQQADNFPEAFSTEVSKMREQ 126
LK K ++ DA+ + + E+ L + LQ+ D A + + +++
Sbjct: 308 LKEKSGVIQDALKKSSKGELTTLIH-------------QLQEKDKLLAAVKEDAAATKDR 354
Query: 127 LLKYQNEYNAVKEREFHNQYRLNSLKEEKIIIVKEFEKITKPGEMEKKMKILRESTEELR 186
+ E KER ++I + ++I G +EK+ + +
Sbjct: 355 CKQLTQEMMTEKERS-------------NVVITRMKDRI---GTLEKEHNVFQNKIHVSY 398
Query: 187 KEIMQKKLEIKNLREDLASKQKQLLKEQKELEELLGHQVVLKDEVAHHQTIPVQIGKEIE 246
+E Q +++ + +RE + ++ L +E L + + + +++ Q+ ++ K +
Sbjct: 399 QETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTT---NQLESKQS--AELNKLRQ 453
Query: 247 KITRKKVEMEKKKIVLEQEVKTLNDSLKKVENKVSAIVDEKENVIKEVEGKRALLEIKER 306
R E+ +K L+QE + + ++ ++ + E E +EV+ + + +
Sbjct: 454 DYARLVNELTEKTGKLQQE-EVQKKNAEQAATQLKVQLQEAERRWEEVQ---SYIRKRTA 509
Query: 307 EHNQLVKLLE---LARENEATSLTERGILDLNLRNSLIDKQNYHDELSRKQREKERDFRN 363
EH + L+ +A+ENE SL + L ++L+ KQ L + E + +
Sbjct: 510 EHEAAQQDLQSKFVAKENEVQSLHSK------LTDTLVSKQQLEQRLMQLM---ESEQKR 560
Query: 364 LRKMELLLKVSWDALRQTQALHQRLLLEMEAIPKDDSTLSERRRELHKEVEVAKRNLAQQ 423
+ K E L D L Q +AL ++ I S S ELHK + +
Sbjct: 561 VNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSA-SVLAEELHKVI------AEKD 613
Query: 424 KIISEMESKLVEQ--QLAEENKLLKEQENMKELVVNLLRMTQIKIDEKEQKSKDFLKAQQ 481
K I + E L + +L + + LK+ +NM L+ ++ Q +E+ + + K QQ
Sbjct: 614 KQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQ 673
Query: 482 KYTNIVKEMKAKDLEIRIHKKKKCEIYRRLREFAKLYD---TIRNERNKFVNLLHKAHQK 538
VK+ K + LE ++ EI ++ EF L D +++E K L+ + K
Sbjct: 674 SV--YVKDDKIRLLEEQLQH----EISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNK 727
Query: 539 ---------VNEIKERHKMSLNELEILRNSAVSQERKL------QNSMLKHANNVTIRES 583
+ E E+ K LE ++E +L +S+ K ++ +++
Sbjct: 728 DVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQN 787
Query: 584 MQNDVRKIVSKLQEMKEKKEAQLNNIDRLANTITM---IEEEMVQLRKRYEKAVQHRNES 640
Q +V +L+++ +K+ ++ +++ L + +E+ VQ K+ KA+ + E
Sbjct: 788 DQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKAL--KEEI 845
Query: 641 GVQLIEREEEICIFYEKINIQEKMKLNGEIEIHLLEEKIQFLKMKIAEKQRQICVTQKLL 700
G +E+ +++ I + +Q +K EE++ +K + EK++ + T K L
Sbjct: 846 GNVQLEKAQQLSITSKVQELQNLLKGK--------EEQMNTMKAVLEEKEKDLANTGKWL 897
Query: 701 PAKRSLDADLAVLQIQFSQCTDRIKDLEKQFVKPDGENRARFLPGKDLTEKEMIQKLDKL 760
LQ + ++++ + +K + + ++F ++ KE +L +L
Sbjct: 898 QD----------LQEENESLKAHVQEVAQHNLK-EASSASQF-EELEIVLKEKENELKRL 945
Query: 761 ELQLAKKEEKLLEKDFIYEQVSRLTDRLCSKTQGCKQDTLLLAKKMNGYQRRIKNATEK- 819
E L ++E L K + + V S+ + KQ A ++ +K +E+
Sbjct: 946 EAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISERE 1005
Query: 820 --MMALVAEL-SMKQALTIELQK--EVREK 844
+ L EL S+K A+ + +K ++REK
Sbjct: 1006 KEISGLWNELDSLKDAVEHQRKKNNDLREK 1035
Score = 70.1 bits (170), Expect = 9e-12
Identities = 133/785 (16%), Positives = 318/785 (40%), Gaps = 90/785 (11%)
Query: 170 EMEKKMKILRESTEELRKEIMQ-KKLEIKNLREDLASKQKQLLKEQKELEELLGHQVVLK 228
+ +++ K++ T++ + E + KK EI+N +L + + +L + L V
Sbjct: 40 KQKREQKLIPTKTDKKKAEKKKNKKKEIQN--GNLHESDSESVPRDFKLSDALA---VED 94
Query: 229 DEVAHHQTIPVQIGKEIEKITRKKVEMEKKKIVLEQEVKTLNDSLKKVENKVSAIVDEKE 288
D+VA +P+ + + + +K + +K+K VLE++V +D+ K KV + K+
Sbjct: 95 DQVA---PVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQ 151
Query: 289 -------NVIKEVEGKRALLEIKEREHNQLVKLLELARENEATSLTERGILDLNLRNSLI 341
K+ G++ + + ++ L+ ++ EA L +
Sbjct: 152 PTPPSEAAASKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQ------------- 198
Query: 342 DKQNYHDELSRKQREKERDFRNLRKMELLLKVS-----WDALRQTQALHQRLLLEMEAIP 396
+ + +K K++ N+ E L+ + D + + +R ++++
Sbjct: 199 ETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPD 258
Query: 397 KDDSTLSERRRELHKEVEVAKRNLAQQKIISEMESKLV-EQQLAEENKLLKEQENMKELV 455
+ + ++L E + + + + +++ + E + LLKE+ + +
Sbjct: 259 QVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDA 318
Query: 456 VNLLRMTQIKIDEKEQKSKDFLKAQQKYTNIVKEMKAKDL--EIRIHKKKKCEIYRRLRE 513
+ ++ + + KD L A K + + K L E+ K++ + R+++
Sbjct: 319 LKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKD 378
Query: 514 FAKLYDTIRNERNKFVNLLHKAHQKVNEIKERHKMSLNELEILRNSAVSQERKLQNSMLK 573
T+ E N F N +H ++Q+ +++ + + ++E + L++++
Sbjct: 379 ---RIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSN 435
Query: 574 HANNVTIRES-----MQNDVRKIVSKLQEMK---EKKEAQLNNIDRLANTITM------- 618
N + ++S ++ D ++V++L E +++E Q N ++ A + +
Sbjct: 436 TTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAER 495
Query: 619 -IEEEMVQLRKRYEKAVQHRNESGVQLIEREEEICIFYEKIN-----------------I 660
EE +RKR + + + + + +E E+ + K+
Sbjct: 496 RWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLME 555
Query: 661 QEKMKLNGE----IEIHLLEEKIQFLKMKIAEKQRQICVTQKLLPAKRSLDADLAVLQIQ 716
E+ ++N E +++ + E+ + LK +I + QI L +A Q
Sbjct: 556 SEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQ 615
Query: 717 FSQCTDRIKDLEKQFVKPDGENRARFLPGKDLTEKEMIQKLDKL---ELQLAKKEEKLLE 773
Q D + + E + + + K +QKL L + A + EK+ +
Sbjct: 616 IKQTEDSLASERDRLTSK--EEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQ 673
Query: 774 KDFIYEQVSRLTDRLCSKTQGCKQDTLLLAKKMNGYQRRIKNATEKMMALVAELSMKQAL 833
++ + RL + K + K +N + +K+ +K+ LV+E K +
Sbjct: 674 SVYVKDDKIRLLEEQLQHEISNKMEEF---KILNDQNKALKSEVQKLQTLVSEQPNKDVV 730
Query: 834 TIELQKEVREKEDFIFTCNSRIEKGLPLNKEIEKEWLKVLRDEEMHALAIAEKSQEFLEA 893
+++K ++EK++ + T +E GL + ++E L +R E ++ ++ Q+
Sbjct: 731 E-QMEKCIQEKDEKLKTVEELLETGL-IQVATKEEELNAIRTENS---SLTKEVQDLKAK 785
Query: 894 DNRQL 898
N Q+
Sbjct: 786 QNDQV 790
>gi|33620775 kinectin 1 isoform a [Homo sapiens]
Length = 1357
Score = 100 bits (250), Expect = 5e-21
Identities = 174/900 (19%), Positives = 376/900 (41%), Gaps = 139/900 (15%)
Query: 67 LKAKYTLLHDAVMSTQESEVQLLQNAKRFTEQIQQQQFHLQQADNFPEAFSTEVSKMREQ 126
L++K+ + V S L + ++ +++ Q Q+ N E+ +V + EQ
Sbjct: 518 LQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQ 577
Query: 127 LLKYQNEYNAVKEREFHNQYRLNSLKEEKIIIVKEFEKITKPGEMEKKMKILRESTEELR 186
NE + ++FH+Q + +L EEL
Sbjct: 578 -----NEALKAQIQQFHSQIAAQT-----------------------SASVL---AEELH 606
Query: 187 KEIMQKKLEIKNLREDLASKQKQLLKEQKELEELLGHQVVLKDEVAHHQTI---PVQIGK 243
K I +K +IK + LAS++ +L +++EL+++ +LK EV Q +
Sbjct: 607 KVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAH 666
Query: 244 EIEKITRKKVEMEKKKIVLE-----------QEVKTLND---SLKKVENKVSAIVDEKEN 289
E+EK+ + + K +LE +E K LND +LK K+ +V E+ N
Sbjct: 667 ELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPN 726
Query: 290 VIKEVEGKRALLEIKEREHNQLVKLLELARENEATSLTERGILDLNLRNSLIDKQNYHDE 349
VE ++ K+ + + +LLE AT E + + NS + K+ +
Sbjct: 727 K-DVVEQMEKCIQEKDEKLKTVEELLETGLIQVATK--EEELNAIRTENSSLTKE--VQD 781
Query: 350 LSRKQREKERDFRNLRKMELLLKVSWDALRQTQALHQRLLLEMEAIPKDDSTLSERRREL 409
L KQ + + F +L +E L KV + + +++ + L E+ + + T+ ++L
Sbjct: 782 LKAKQND-QVSFASL--VEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTV----QDL 834
Query: 410 HKEVEVAKRNLAQQKIISEMESKLVEQQLAEENKLLKEQENMKELVVNLLRMTQIKIDEK 469
+E++ K + ++ + + + +N L ++E M + + ++EK
Sbjct: 835 KQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTM--------KAVLEEK 886
Query: 470 EQKSKDFLKAQQKYTNIVKEMKAKDLEIRIHKKKKCEIYRRLREFAKLYDTIRNERNKFV 529
E+ + K Q + +KA E+ H K+ + E + NE +
Sbjct: 887 EKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLE 946
Query: 530 NLLHKAH-------QKVNEIKERHKMSLNELEILRNSAVSQERKLQNSMLKHANNVTIRE 582
+L + Q + ++++ +K+ +++E L+ Q + +S H + +
Sbjct: 947 AMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLK----QQNYQQASSFPPHEELLKVIS 1002
Query: 583 SMQNDVRKIVSKLQEMKEKKEAQ--LNN---------IDRLANTITMIEEEMVQLRKRYE 631
+ ++ + ++L +K+ E Q NN ++ LA+T M+++++ + K +
Sbjct: 1003 EREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQ 1062
Query: 632 KAVQHRNESGVQLIEREEEICIFYEKINIQEKMK------------------LNGEIEIH 673
+ V+ V+L E +E + + K+++ + +G E+
Sbjct: 1063 QQVE-----AVEL-EAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVK 1116
Query: 674 LLEEKIQ-------FLKMKIAEKQRQICVTQKLL-PAKRSLDADLAVLQIQFSQCTDRIK 725
+LE K++ L+++ + + + T+ +L +RS++ + +++ + IK
Sbjct: 1117 VLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIK 1176
Query: 726 DLEKQFVKPDGENRARFLPGKDL----TEKEMIQ-KLDKLELQLAKKEEKLLE-KDFIYE 779
++ F + E KD+ E+E ++ +L+K E++ + ++ E KD + E
Sbjct: 1177 QMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTE 1236
Query: 780 QVSRLTDRLCSKTQGCKQDTLLLAKKMNGYQRRIKNATEKMMALVAEL-SMKQALTIELQ 838
+L D S+ ++ LL ++N +++ + + +L +Q+L +
Sbjct: 1237 LQKKLDDSY-SEAVRQNEELNLLKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQS 1295
Query: 839 KEVREKEDFIFTCNSRIEKGLPLNKEIEKEWLKVLRDEEMHALAIAEKSQEFLEADNRQL 898
K V+ D NS + P + EKE + V ++ + L Q+ L+A N+QL
Sbjct: 1296 KIVKAAGDTTVIENSDVS---PETESSEKETMSVSLNQTVTQL------QQLLQAVNQQL 1346
Score = 95.5 bits (236), Expect = 2e-19
Identities = 174/915 (19%), Positives = 365/915 (39%), Gaps = 169/915 (18%)
Query: 63 RMAALKAKYTLLHDAVMSTQESEVQLLQNAKRFTEQIQQQQFHLQQADNFPEAFSTEVSK 122
R+ L+ ++ + + + + + Q+ ++ EQ++ + HL+Q +
Sbjct: 379 RIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGI---------- 428
Query: 123 MREQLLKYQNEYNAVKEREFHNQYRLNSLKEEKIIIVKEFEKITKPGEMEKKMKILREST 182
+R+ + N+ + + E LN L+++ +V E L E T
Sbjct: 429 LRDAVSNTTNQLESKQSAE------LNKLRQDYARLVNE----------------LTEKT 466
Query: 183 EELRKEIMQKKLEIKNLREDLASKQKQLLKEQKELEELLGHQVVLKDEVAHHQTIP---- 238
+L++E +QK KN + + QL + ++ EE+ Q ++ A H+
Sbjct: 467 GKLQQEEVQK----KNAEQAATQLKVQLQEAERRWEEV---QSYIRKRTAEHEAAQQDLQ 519
Query: 239 ---VQIGKEIEKITRKKVEMEKKKIVLEQEVKTLNDSLKKVENKVSAIVDEKENVIKEVE 295
V E++ + K + K LEQ + L +S +K NK ++ + ++++++ E
Sbjct: 520 SKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNE 579
Query: 296 GKRALLEIKEREHNQLVKLLELARENEATSLTERGILDLNLRNSLIDKQNYHDELSRKQR 355
+A + ++ H+Q +A + A+ L E + ++ I KQ S + R
Sbjct: 580 ALKAQI---QQFHSQ------IAAQTSASVLAEELHKVIAEKDKQI-KQTEDSLASERDR 629
Query: 356 --EKERDFRNLRKMELLLKVSWDALR-----QTQALHQRLLLEMEAIPKDD--------- 399
KE + ++++ M LLK L+ Q A H+ ++ KDD
Sbjct: 630 LTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQL 689
Query: 400 ----STLSERRRELHKEVEVAKRNLAQ-QKIISEMESKLVEQQLAEENKLLKEQENMKEL 454
S E + L+ + + K + + Q ++SE +K V +Q+ K ++E++ +
Sbjct: 690 QHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQM---EKCIQEKDEKLKT 746
Query: 455 VVNLLRMTQIKIDEKEQKSKDFLKAQQKYTNIVKEMKAKDLEIRIHKKKKCEIYRRLREF 514
V LL I++ KE++ T V+++KAK + F
Sbjct: 747 VEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQND--------------QVSF 792
Query: 515 AKLYDTIRNERNKFVNLLHKAHQKVNEIKERHKMSLNELEILRNSAVSQERKLQNSMLK- 573
A L + ++ ++H+ K+ ++E + L L++ Q+ K + LK
Sbjct: 793 ASLVEELK-------KVIHEKDGKIKSVEELLEAEL--LKVANKEKTVQDLKQEIKALKE 843
Query: 574 HANNVTIRESMQNDVRKIVSKLQEMKEKKEAQLNNIDR--------LANT---ITMIEEE 622
NV + ++ Q + V +LQ + + KE Q+N + LANT + ++EE
Sbjct: 844 EIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEE 903
Query: 623 MVQLRKRYEKAVQHRNESGVQLIEREEEICIFYEKIN---------------IQEKMKLN 667
L+ ++ QH + + EE + EK N + K +L
Sbjct: 904 NESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLL 963
Query: 668 GEI--EIHLLEEKIQFLKMKIAEKQRQICVTQKLLPAKRSLDADLAVLQIQFSQCTDRIK 725
++ E L + +I+ LK + ++ ++LL + +++ L + D ++
Sbjct: 964 QDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVE 1023
Query: 726 DLEKQFVKPDGENRARFLPGKDLTEK--EMIQKLDKLELQLAKK-----EEKLLEKDFIY 778
K+ DL EK E ++ L E L K +E+ + + +
Sbjct: 1024 HQRKK--------------NNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVE 1069
Query: 779 EQVSRLTDRLCSKTQGCKQDTLLLAKKMNGYQRRIK------NATEKMMALVAELSMKQA 832
+ + +L K L + ++G++++ K + +E++ L +L
Sbjct: 1070 LEAKEVLKKLFPKVS--VPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADE 1127
Query: 833 LTIELQKEVREKEDFIFTCNSRIEKGLPLNKEIEKEWLKVLRDEE-------MHALAIAE 885
+ LQ E + + + ++K ++ E +W KV DE + +E
Sbjct: 1128 MHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKW-KVKVDESHKTIKQMQSSFTSSE 1186
Query: 886 KSQEFLEADNRQLPN 900
+ E L ++N+ + N
Sbjct: 1187 QELERLRSENKDIEN 1201
Score = 90.1 bits (222), Expect = 9e-18
Identities = 163/810 (20%), Positives = 341/810 (42%), Gaps = 114/810 (14%)
Query: 67 LKAKYTLLHDAVMSTQESEVQLLQNAKRFTEQIQQQQFHLQQADNFPEAFSTEVSKMREQ 126
LK K ++ DA+ + + E+ L + LQ+ D A + + +++
Sbjct: 308 LKEKSGVIQDALKKSSKGELTTLIH-------------QLQEKDKLLAAVKEDAAATKDR 354
Query: 127 LLKYQNEYNAVKEREFHNQYRLNSLKEEKIIIVKEFEKITKPGEMEKKMKILRESTEELR 186
+ E KER ++I + ++I G +EK+ + +
Sbjct: 355 CKQLTQEMMTEKERS-------------NVVITRMKDRI---GTLEKEHNVFQNKIHVSY 398
Query: 187 KEIMQKKLEIKNLREDLASKQKQLLKEQKELEELLGHQVVLKDEVAHHQTIPVQIGKEIE 246
+E Q +++ + +RE + ++ L +E L + + + +++ Q+ ++ K +
Sbjct: 399 QETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTT---NQLESKQS--AELNKLRQ 453
Query: 247 KITRKKVEMEKKKIVLEQEVKTLNDSLKKVENKVSAIVDEKENVIKEVEGKRALLEIKER 306
R E+ +K L+QE + + ++ ++ + E E +EV+ + + +
Sbjct: 454 DYARLVNELTEKTGKLQQE-EVQKKNAEQAATQLKVQLQEAERRWEEVQ---SYIRKRTA 509
Query: 307 EHNQLVKLLE---LARENEATSLTERGILDLNLRNSLIDKQNYHDELSRKQREKERDFRN 363
EH + L+ +A+ENE SL + L ++L+ KQ L + E + +
Sbjct: 510 EHEAAQQDLQSKFVAKENEVQSLHSK------LTDTLVSKQQLEQRLMQLM---ESEQKR 560
Query: 364 LRKMELLLKVSWDALRQTQALHQRLLLEMEAIPKDDSTLSERRRELHKEVEVAKRNLAQQ 423
+ K E L D L Q +AL ++ I S S ELHK + +
Sbjct: 561 VNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSA-SVLAEELHKVI------AEKD 613
Query: 424 KIISEMESKLVEQ--QLAEENKLLKEQENMKELVVNLLRMTQIKIDEKEQKSKDFLKAQQ 481
K I + E L + +L + + LK+ +NM L+ ++ Q +E+ + + K QQ
Sbjct: 614 KQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQ 673
Query: 482 KYTNIVKEMKAKDLEIRIHKKKKCEIYRRLREFAKLYD---TIRNERNKFVNLLHKAHQK 538
VK+ K + LE ++ EI ++ EF L D +++E K L+ + K
Sbjct: 674 SV--YVKDDKIRLLEEQLQH----EISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNK 727
Query: 539 ---------VNEIKERHKMSLNELEILRNSAVSQERKL------QNSMLKHANNVTIRES 583
+ E E+ K LE ++E +L +S+ K ++ +++
Sbjct: 728 DVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQN 787
Query: 584 MQNDVRKIVSKLQEMKEKKEAQLNNIDRLANTITM---IEEEMVQLRKRYEKAVQHRNES 640
Q +V +L+++ +K+ ++ +++ L + +E+ VQ K+ KA+ + E
Sbjct: 788 DQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKAL--KEEI 845
Query: 641 GVQLIEREEEICIFYEKINIQEKMKLNGEIEIHLLEEKIQFLKMKIAEKQRQICVTQKLL 700
G +E+ +++ I + +Q +K EE++ +K + EK++ + T K L
Sbjct: 846 GNVQLEKAQQLSITSKVQELQNLLKGK--------EEQMNTMKAVLEEKEKDLANTGKWL 897
Query: 701 PAKRSLDADLAVLQIQFSQCTDRIKDLEKQFVKPDGENRARFLPGKDLTEKEMIQKLDKL 760
LQ + ++++ + +K + + ++F ++ KE +L +L
Sbjct: 898 QD----------LQEENESLKAHVQEVAQHNLK-EASSASQF-EELEIVLKEKENELKRL 945
Query: 761 ELQLAKKEEKLLEKDFIYEQVSRLTDRLCSKTQGCKQDTLLLAKKMNGYQRRIKNATEK- 819
E L ++E L K + + V S+ + KQ A ++ +K +E+
Sbjct: 946 EAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISERE 1005
Query: 820 --MMALVAEL-SMKQALTIELQK--EVREK 844
+ L EL S+K A+ + +K ++REK
Sbjct: 1006 KEISGLWNELDSLKDAVEHQRKKNNDLREK 1035
Score = 70.1 bits (170), Expect = 9e-12
Identities = 133/785 (16%), Positives = 318/785 (40%), Gaps = 90/785 (11%)
Query: 170 EMEKKMKILRESTEELRKEIMQ-KKLEIKNLREDLASKQKQLLKEQKELEELLGHQVVLK 228
+ +++ K++ T++ + E + KK EI+N +L + + +L + L V
Sbjct: 40 KQKREQKLIPTKTDKKKAEKKKNKKKEIQN--GNLHESDSESVPRDFKLSDALA---VED 94
Query: 229 DEVAHHQTIPVQIGKEIEKITRKKVEMEKKKIVLEQEVKTLNDSLKKVENKVSAIVDEKE 288
D+VA +P+ + + + +K + +K+K VLE++V +D+ K KV + K+
Sbjct: 95 DQVA---PVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQ 151
Query: 289 -------NVIKEVEGKRALLEIKEREHNQLVKLLELARENEATSLTERGILDLNLRNSLI 341
K+ G++ + + ++ L+ ++ EA L +
Sbjct: 152 PTPPSEAAASKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQ------------- 198
Query: 342 DKQNYHDELSRKQREKERDFRNLRKMELLLKVS-----WDALRQTQALHQRLLLEMEAIP 396
+ + +K K++ N+ E L+ + D + + +R ++++
Sbjct: 199 ETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPD 258
Query: 397 KDDSTLSERRRELHKEVEVAKRNLAQQKIISEMESKLV-EQQLAEENKLLKEQENMKELV 455
+ + ++L E + + + + +++ + E + LLKE+ + +
Sbjct: 259 QVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDA 318
Query: 456 VNLLRMTQIKIDEKEQKSKDFLKAQQKYTNIVKEMKAKDL--EIRIHKKKKCEIYRRLRE 513
+ ++ + + KD L A K + + K L E+ K++ + R+++
Sbjct: 319 LKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKD 378
Query: 514 FAKLYDTIRNERNKFVNLLHKAHQKVNEIKERHKMSLNELEILRNSAVSQERKLQNSMLK 573
T+ E N F N +H ++Q+ +++ + + ++E + L++++
Sbjct: 379 ---RIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSN 435
Query: 574 HANNVTIRES-----MQNDVRKIVSKLQEMK---EKKEAQLNNIDRLANTITM------- 618
N + ++S ++ D ++V++L E +++E Q N ++ A + +
Sbjct: 436 TTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAER 495
Query: 619 -IEEEMVQLRKRYEKAVQHRNESGVQLIEREEEICIFYEKIN-----------------I 660
EE +RKR + + + + + +E E+ + K+
Sbjct: 496 RWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLME 555
Query: 661 QEKMKLNGE----IEIHLLEEKIQFLKMKIAEKQRQICVTQKLLPAKRSLDADLAVLQIQ 716
E+ ++N E +++ + E+ + LK +I + QI L +A Q
Sbjct: 556 SEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQ 615
Query: 717 FSQCTDRIKDLEKQFVKPDGENRARFLPGKDLTEKEMIQKLDKL---ELQLAKKEEKLLE 773
Q D + + E + + + K +QKL L + A + EK+ +
Sbjct: 616 IKQTEDSLASERDRLTSK--EEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQ 673
Query: 774 KDFIYEQVSRLTDRLCSKTQGCKQDTLLLAKKMNGYQRRIKNATEKMMALVAELSMKQAL 833
++ + RL + K + K +N + +K+ +K+ LV+E K +
Sbjct: 674 SVYVKDDKIRLLEEQLQHEISNKMEEF---KILNDQNKALKSEVQKLQTLVSEQPNKDVV 730
Query: 834 TIELQKEVREKEDFIFTCNSRIEKGLPLNKEIEKEWLKVLRDEEMHALAIAEKSQEFLEA 893
+++K ++EK++ + T +E GL + ++E L +R E ++ ++ Q+
Sbjct: 731 E-QMEKCIQEKDEKLKTVEELLETGL-IQVATKEEELNAIRTENS---SLTKEVQDLKAK 785
Query: 894 DNRQL 898
N Q+
Sbjct: 786 QNDQV 790
>gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]
Length = 1088
Score = 100 bits (249), Expect = 6e-21
Identities = 144/682 (21%), Positives = 288/682 (42%), Gaps = 93/682 (13%)
Query: 96 TEQIQQQQFHLQQADNFPEAFSTEVSKMREQL-LKYQNEYNAVKEREFHNQYRLNSLKEE 154
T ++ + + H+ ++ E E S +RE++ +++N ++ K + + +K+
Sbjct: 333 TRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQT---VIEMKDS 389
Query: 155 KIIIVKEFEKITKPGEMEKKMKILRE----STEELRKEIMQKKL----------EIKNLR 200
KI ++ + ++E+++++L+ STEE +E+ Q ++ +I ++
Sbjct: 390 KISSMERGLR-----DLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVK 444
Query: 201 EDLASKQKQLLKEQKELEELLGHQVVLKDEVAHHQTIPVQIGKEIEKITRKKVEMEKKKI 260
++L+ K +LL Q +LE L D H + + + + ++ + E++ ++
Sbjct: 445 QELSRKDTELLALQTKLETLTNQ---FSDSKQHIEVLKESLTAKEQRAAILQTEVDALRL 501
Query: 261 VLEQEVKTLNDSLKKVENKVSAIVDEKENVIKEVEGKRALLEIKEREHNQLVKLLELARE 320
LE++ LN K++++ + +EK E+ + +L++KER+ N L K +E
Sbjct: 502 RLEEKETMLNKKTKQIQD----MAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIE---- 553
Query: 321 NEATSLTERGILDLNLRNSLIDKQNYHDELSRKQREKERDFRNLRKMELLLKVSWDALRQ 380
NL+ L DK+ L + + + D N + L +AL +
Sbjct: 554 --------------NLQEQLRDKEKQMSSLKERVKSLQADTTN---TDTALTTLEEALAE 596
Query: 381 TQALHQRLLLEMEAIPKDDSTLSERRRELHKEVEVAKRNLAQQKIISEMESKLVEQQLAE 440
+ +RL E +D+ RE +E++ K++L K + E S L +
Sbjct: 597 KERTIERL---KEQRDRDE-------REKQEEIDNYKKDL---KDLKEKVSLLQGDLSEK 643
Query: 441 ENKLLKEQENMKELVVN-LLRMTQIKIDE--KEQKSKDFLKAQQKYTNIVKEMKAKDLEI 497
E LL +E+ L + L + +++K E EQK ++ LK + + +K+ LE
Sbjct: 644 EASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQ----LKKAHEAALEA 699
Query: 498 RIHKKKKCEIYRRLREFAKLYDTIRNERNKFVNLLHKAHQKVNEIKERHKMSLNELEILR 557
R + I RE + D + + LL + NE ++ K ++ L
Sbjct: 700 RASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDK----KIAELE 755
Query: 558 NSAVSQERKLQNSMLKHANNVTIRESMQ--NDVRKIVSKLQEMKEKKEAQLNNIDRLANT 615
Q +K+ N LKH V ++S Q + R+ L + ++ + L D
Sbjct: 756 RQVKDQNKKVAN--LKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEE 813
Query: 616 ITMIEEEMVQLRKRYEKAVQHRNESGVQLIEREEEICIFYEKINIQ-EKMKLNGEIEIHL 674
+ E VQ+ E + + ++ EE+ + EK+ + E MK
Sbjct: 814 LEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQS 873
Query: 675 LEEKIQFLKMKIAEKQRQI-----CVTQKLLPAKRSLDADLAVLQIQFSQ--------CT 721
L EK L AE+++ + + LL A DA++A+L++ S+
Sbjct: 874 LAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAAL 933
Query: 722 DRIKDLEKQFVKPDGENRARFL 743
R KD Q +K +NR + +
Sbjct: 934 KREKDRLVQQLKQQTQNRMKLM 955
Score = 86.3 bits (212), Expect = 1e-16
Identities = 149/725 (20%), Positives = 302/725 (41%), Gaps = 90/725 (12%)
Query: 184 ELRKEIMQKKLEIKNLREDLASKQKQLLKEQKELEELLGHQVVLKDEVAHHQTIPVQIGK 243
+L+ ++ + E LR+D+ K+ +L ++ ++ + + + + I K
Sbjct: 153 DLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWK 212
Query: 244 EIEKITRKKVEMEKKKI-VLEQEVKTLNDSLKKVENKVSAIVDEKENVIKEVEGKRALLE 302
E ++ +++ + + I L+ E++ D + + S+ E E + L
Sbjct: 213 EQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHA 272
Query: 303 IKEREHNQLVKLLELARENEATSLTERGILDLNLRNSLIDK---QNYHDELSRKQREKER 359
ER+ +L L + E E T++ L N R+ I K LS K E++
Sbjct: 273 EHERQAKELFLLRKTLEEMELRIETQKQTL--NARDESIKKLLEMLQSKGLSAKATEEDH 330
Query: 360 DFRNLRKMELLLKVSWDALRQTQALHQRLLLEMEAIPKDDSTLSERRRELHKEVEVAK-- 417
+ R R E + V H LLE + K++S L R E+H+ E A
Sbjct: 331 E-RTRRLAEAEMHVH----------HLESLLEQKE--KENSML---REEMHRRFENAPDS 374
Query: 418 -RNLAQQKIISEMESKLVEQQ-----LAEENKLLKE---------QENMKELVVNLL--- 459
+ A Q +I +SK+ + L EE ++LK +E MK++ V
Sbjct: 375 AKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSK 434
Query: 460 ----RMTQIKIDEKEQKSKDFLKAQQKYTNIVKEMKAKDLEIRIHKKKKCEIYRRLREFA 515
++ Q+K E +K + L Q K + + I + K+ +R
Sbjct: 435 FMKNKIGQVK-QELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQ 493
Query: 516 KLYDTIRNERNKFVNLLHKAHQKVNEIKERHKMSLNELEILRNSAVSQERKLQNSMLKHA 575
D +R + +L+K +++ ++ E E+ L++ +ERK+ N + K
Sbjct: 494 TEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKV-NVLQKKI 552
Query: 576 NNVTIRESMQNDVRKIVSKLQEMKEKKEAQLNNIDRLANTITMIEEEMVQLRKRYEKAVQ 635
N+ + D K +S L+E + +A N D +T +EE + + + E+ +
Sbjct: 553 ENL---QEQLRDKEKQMSSLKERVKSLQADTTNTD---TALTTLEEALAEKERTIERLKE 606
Query: 636 HRNESGVQLIEREEEICIFYEKINIQEKMKLNGEIEIHLLEEKIQFLKMKIAEKQRQICV 695
R+ ERE++ E+I+ +K ++ L+EK+ L+ ++EK+ +
Sbjct: 607 QRDRD-----EREKQ-----EEIDNYKK-------DLKDLKEKVSLLQGDLSEKEASLLD 649
Query: 696 TQK----LLPAKRSLDADLAVLQIQFSQCTDRIKDLEKQFVKP-DGENRARFLPGKDLTE 750
++ L + D+ L L+I Q + +E Q K + AR P
Sbjct: 650 LKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASP------ 703
Query: 751 KEMIQKLDKLELQLAKKEEKLLEKDFIYEQVSRLTDRLCSKTQGCKQDTLLLAKKMNGYQ 810
EM ++ LE ++ + ++ E +V RL + L + + K D KK+ +
Sbjct: 704 -EMSDRIQHLEREITRYKD---ESSKAQAEVDRLLEIL-KEVENEKNDK---DKKIAELE 755
Query: 811 RRIKNATEKMMALVAELSMKQALTIELQKEVREKEDFIFTCNSRIEKGLPLNKEIEKEWL 870
R++K+ +K+ L + +++ + ++ +E R +ED + + +++ L + +E
Sbjct: 756 RQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELE 815
Query: 871 KVLRD 875
+ LR+
Sbjct: 816 EALRE 820
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 100 bits (249), Expect = 6e-21
Identities = 165/856 (19%), Positives = 384/856 (44%), Gaps = 66/856 (7%)
Query: 82 QESEVQLLQNAKRFTEQIQQQQFHLQQADNFPEAFSTEVSKMREQLLKYQNE-----YNA 136
+E +++ Q +R + ++QQ +Q + E + REQ LK + E
Sbjct: 403 REQQLRREQQLRREQQLRREQQLRREQEEERHE--QKHEQERREQRLKREQEERRDWLKR 460
Query: 137 VKEREFHNQYRLNSL-----KEEKIIIVKEFEKITKPGEMEKKMKILRESTEELRKEIMQ 191
+E E H Q R +EE+ + E+ + + E++ + LR EE R++ ++
Sbjct: 461 EEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLK 520
Query: 192 KKLEIKNLREDLASKQKQLLKEQKELEELLGHQVVLK--DEVAHHQTIPVQIGKEIEKIT 249
++ E + L++ L S+Q QL +EQ+E E L + K ++ Q + + + +++
Sbjct: 521 RQEEEERLQQRLRSEQ-QLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLL 579
Query: 250 RKKVEMEKKKIVLEQEVKTLNDSLKKVENKVSAIVDEKENVIK----EVEGKRALL---E 302
+++ E ++++ EQE + L LK+ E + + +E +K E E ++ LL E
Sbjct: 580 KREEERRQQRLKREQE-ERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEE 638
Query: 303 IKEREHNQLVKLLELARENEATSLTERGILDLNLRNSLIDKQNYHDELSRKQREKERDFR 362
+ER QL + + RE E L+ L+ +++ EL+ +++E+ R+
Sbjct: 639 QEERRQQQLRREQQERREQRLKREEEEERLEQRLKRE-HEEERREQELAEEEQEQARERI 697
Query: 363 NLRKMELLLKVSWDALRQTQALHQRLLLEMEAIPKDDSTLSERRRELHKEVEVAKRNLAQ 422
R + ++ +A + ++ R + + + RRRE + + +R Q
Sbjct: 698 KSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQ 757
Query: 423 QKIISEMESKLVEQQLAEENKLLKEQENMKELVVNLLRMTQIKIDEKEQKSKDFLKAQQK 482
Q+ E Q AEE Q + R Q++ +E++Q+ + FL +++
Sbjct: 758 QQ-EEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEE 816
Query: 483 YTNIVKEMKAKDLEIR-IHKKKKCEIYRRLREFAKLYDTIRNERNKFVNLLHKAHQK--- 538
++ + ++ E++ + ++++ + R ++ + D ++ ++ + + + QK
Sbjct: 817 KEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRW 876
Query: 539 -VNEIKERHKMSLNELEILRNSAVSQERKLQNSMLKHANNVTIRESMQNDVRKIVSKLQE 597
+ E ++R + +L L+ +++ LQ E +Q + R+ +
Sbjct: 877 QLEEERKRRRHTLYAKPALQEQLRKEQQLLQEE----------EEELQREERE-----KR 921
Query: 598 MKEKKEAQLNNIDRLANTITMIEEEMVQLRKRYEKAVQHRNESGVQLIEREEEIC-IFYE 656
++++E Q ++L + E + R+R E+ Q+R + +Q ++EE++ E
Sbjct: 922 RRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQ--QKEEQLLGEEPE 979
Query: 657 KINIQEKMKLNGEIEIHLLEEKIQFLKMKIAEKQRQICVTQKLLPAKRSLDADLAVLQIQ 716
K QE+ K E E L +E+ Q L+ + +++RQ ++ K L + L ++
Sbjct: 980 KRRRQEREKKYRE-EEELQQEEEQLLREEREKRRRQ--EWERQYRKKDELQQEEEQL-LR 1035
Query: 717 FSQCTDRIKDLEKQFVKPD---GENRARFLPGKDLTEKEMIQKLDKLELQLAKKEEKLLE 773
+ R+++ E+Q+ + + E ++ ++ +++ + E +L ++EE+LL
Sbjct: 1036 EEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLR 1095
Query: 774 KDFIYEQVSRLTDRLCSKTQGCKQDTLLLAKKMNGYQRRIKNATEKMMALVAELSMKQAL 833
++ ++ + +R C + + +Q+ L ++ ++R + E+ E+ ++
Sbjct: 1096 EE-PEKRRRQERERQCREEEELQQEEEQLLREER--EKRRRQELERQYREEEEVQQEEEQ 1152
Query: 834 TIELQKEVREKEDFIFTCNSRIEKGLPLNKEIEKEWLKVLRDEEMHALAIAEKSQEFLEA 893
+ + E R +++ +E+ +E+++E ++LR+E+ E+ E
Sbjct: 1153 LLREEPEKRRRQE--------LERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEE 1204
Query: 894 DNRQLPNGVYTTAEQR 909
RQ Y +QR
Sbjct: 1205 LQRQKRKQRYRDEDQR 1220
Score = 89.4 bits (220), Expect = 1e-17
Identities = 179/910 (19%), Positives = 382/910 (41%), Gaps = 130/910 (14%)
Query: 78 VMSTQESEVQLLQNAKRFTEQIQQQQFHLQQADNFPEAFSTEVSKMREQLLKYQNEYNAV 137
++ +E E+Q + KR Q Q++Q+ ++ ++ + EQLL+ + E
Sbjct: 905 LLQEEEEELQREEREKR-RRQEQERQYREEE----------QLQQEEEQLLREEREKRRR 953
Query: 138 KEREFHNQYRLN-SLKEEKIIIVKEFEKITKPGEMEKKMK-----------ILRESTEEL 185
+ERE QYR + L++++ ++ E + + E EKK + +LRE E+
Sbjct: 954 QERE--RQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKR 1011
Query: 186 RKEIMQKKLEIKNLREDLASKQKQLLKEQKELEELLGHQVVLKDEVAHHQTIPVQIGKEI 245
R++ +++ K ++L +++QLL+E++E L + ++E Q +G+E
Sbjct: 1012 RRQEWERQYRKK---DELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEER 1068
Query: 246 EKITRKKVEMEKKKIVLEQEVKTLNDSLKKVENKVSAIVDEKENVIKEVEGKRALLEI-- 303
E R+++E + +K E+E++ + L + E + + + +E E ++ ++
Sbjct: 1069 ETRRRQELERQYRK---EEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLR 1125
Query: 304 KEREHNQLVKLLELARENEATSLTERGILDLNLRNSLIDKQNYHDELSRKQREKERDFRN 363
+ERE + +L RE E E +L ++ EL R+ RE+E
Sbjct: 1126 EEREKRRRQELERQYREEEEVQQEEEQLLREE------PEKRRRQELERQYREEE---EL 1176
Query: 364 LRKMELLLKVSWDALRQTQALHQRLLLEMEAIPKDDSTLSE-RRRELHKEVEVAKRNLAQ 422
++ E LL+ + RQ + R E++ + E +R +L + E K N +
Sbjct: 1177 QQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVR 1236
Query: 423 QKIISEMESKLVEQQLAEENKLLKEQENMKELVVNLLRMTQIKIDEKE-----QKSKDFL 477
+ + + EQ E+ L+++++ ++L +LL Q + E+E Q+ + F
Sbjct: 1237 DNKV-YCKGRENEQFRQLEDSQLRDRQSQQDL-QHLLGEQQERDREQERRRWQQRDRHFP 1294
Query: 478 KAQQKYTNIVKEMKAKD----------LEIRIHKKKKCEIYRRLREFAKLYDTIRNERNK 527
+ +Q KE K +D E R K+++ E R+ RE +L + +
Sbjct: 1295 EEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLR 1354
Query: 528 FVNLLHKAHQKVNEIKERHKMSLNELEILRNSAVSQERKL---QNSMLKHANNVTIRESM 584
K ++ +E+ + L E + LR +ERK + + +R+
Sbjct: 1355 RQERDRKFREEELRHQEQGRKFLEEEQRLRRQ--ERERKFLKEEQQLRCQEREQQLRQDR 1412
Query: 585 QNDVRKIVSKL--QEMKEKKEAQLNNIDRLANTITMIEEEMVQLRKRY------EKAVQH 636
R+ +L QE K + + R +EEE ++R+ E+ +Q
Sbjct: 1413 DRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQE 1472
Query: 637 RNESGVQLIEREEEICIFYEKINIQEKMK----------------LNGEIEIHLLEEKIQ 680
R E + ER+ + +++ QE+ + L E ++H + + +
Sbjct: 1473 REEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRK 1532
Query: 681 FL---------------------KMKIAEKQRQICVTQKLLPAKRSLDADLAVLQIQFSQ 719
FL K + E+ RQ Q+L +R L +++ +
Sbjct: 1533 FLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQE 1592
Query: 720 CTDRIKDLEKQFVKPDGENRARFLPGKDLTEKE-MIQKLDKLELQLAKKEEKLLEKDFIY 778
+ + E+Q + +G+ + R + E E ++Q+ ++ +L +++ K LE++
Sbjct: 1593 QERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQL 1652
Query: 779 EQVSRLTDRLCSKTQGCKQDTLLLA-------------KKMNGYQRRIKNATEKMMALVA 825
+ R + + +++ LL +K +++++ + L
Sbjct: 1653 RRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQE 1712
Query: 826 ELSMKQALTIELQKEVREKEDF-IFTCNSRIEKGLPLNKEIEKEWLKVLRDEEMHALAIA 884
E +++ EL+++ RE+E T ++ + K +E+E L+ R+E+ L
Sbjct: 1713 EQQLRRQ---ELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQ--LRRQ 1767
Query: 885 EKSQEFLEAD 894
E+ ++F E +
Sbjct: 1768 ERDRKFREEE 1777
Score = 81.6 bits (200), Expect = 3e-15
Identities = 132/702 (18%), Positives = 301/702 (42%), Gaps = 71/702 (10%)
Query: 20 DQEPIYAIVPTINIQDERFVDLSETPAFIFLHE---LHAMGKLPGT---RMAALKAKYTL 73
D + + I+ +++ VD +E FIF +A+G+ G + A K +L
Sbjct: 50 DPKTVDLILELLDLDSNGRVDFNEFLLFIFKVAQACYYALGQATGLDEEKRARCDGKESL 109
Query: 74 LHDAVMSTQESEVQLLQNAKRFTEQIQQQQFHLQQADNFPEAFSTEVSKMREQLL---KY 130
L D +E + + ++ E+ Q++ +Q A E S+ +E+L +
Sbjct: 110 LQDR--RQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQ 167
Query: 131 QNEYNAVKEREFHNQYRLNSLKEEKIIIVKEFEKITKPGEMEKKMKILRESTEELRKEIM 190
+ + ++R+ + +EE++ K E P E + + + L E + R+E
Sbjct: 168 RRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQ 227
Query: 191 QKKLEIKNLREDLASKQKQLLKEQKELEELLGHQVVLKDEVAHHQTIPVQIGKEIEKITR 250
Q++ E R+D ++++ + +K L + L++E Q + +++ K+ R
Sbjct: 228 QQRRE----RQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLER 283
Query: 251 KKVEMEKKKIVLEQEVKTLNDSLKKVENKVSAIVDEKENVIKEVEGKRALLEIKEREHNQ 310
+++ E+++ +Q+ L++ + + E++ +E + +R E ER Q
Sbjct: 284 QELRRERQEEEQQQQRLRREQQLRRKQEEERR---EQQEERREQQERREQQE--ERREQQ 338
Query: 311 LVKLLELARENEATSLTERGILDLNLRNSLIDKQNYHDELSRKQREKERDFRNLRKMELL 370
L + E RE + R+++E+ER + LR+ +
Sbjct: 339 LRREQEERREQQL----------------------------RREQEEERREQQLRREQEE 370
Query: 371 LKVSWDALRQTQALHQRLLLEMEAIPKDDSTLSERRRELHKEVEVAKRNLAQQKIISEME 430
+ R+ Q ++ L + + ++ E++ +++ ++ +Q++ E E
Sbjct: 371 ERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQE 430
Query: 431 SKLVEQ---QLAEENKLLKEQENMKELV---------VNLLRMTQIKIDEKEQKSKDFLK 478
+ EQ Q E +L +EQE ++ + R Q+K D++E++ + +LK
Sbjct: 431 EERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLK 490
Query: 479 AQQKYTNIVKEMKAKDL-----EIRIHKKKKCEIYRRLREFAKLYDTIRNER-NKFVNLL 532
+++ +E + + L E R + K+ E RL++ + +R E+ + LL
Sbjct: 491 LEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLL 550
Query: 533 HKAHQKVNEIKERHKMSLNELEILRNSAVSQERKLQNSMLKHANNVTIRESMQNDVRKIV 592
+ +K E + R + E E R+ + +E + + LK + + ++ R+ V
Sbjct: 551 KREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLK---REEV 607
Query: 593 SKLQEMKEKKEAQLNNIDRLANTITMIEEEMVQLRKRYEKAVQHRNESGVQLIEREEEIC 652
+L E +E++E +L + + + Q +R ++ + + E Q ++REEE
Sbjct: 608 ERL-EQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEE 666
Query: 653 IFYEKINIQ-EKMKLNGEIEIHLLEEKIQFLKMKIAEKQRQI 693
+++ + E+ + E+ E+ + +K +I + Q Q+
Sbjct: 667 RLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQL 708
Score = 70.9 bits (172), Expect = 6e-12
Identities = 144/687 (20%), Positives = 289/687 (42%), Gaps = 100/687 (14%)
Query: 70 KYTLLHDAVMSTQESE--VQLLQNAKRFTEQIQQQQFHLQQADNFPEAFSTEVSKMREQL 127
++ L D+ + ++S+ +Q L ++ ++ Q+++ Q+ +FPE E + +E
Sbjct: 1249 QFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKE-- 1306
Query: 128 LKYQNEYNAVKEREFHNQYRLNSLKEEKIIIVKEFEKITKPGEMEKKMK----ILRESTE 183
K R+ +Q EEK ++ +E E+ + E ++K + +L+E E
Sbjct: 1307 ---------AKRRDRKSQ-------EEKQLLREEREEKRRRQETDRKFREEEQLLQEREE 1350
Query: 184 E-LRKEIMQKKLEIKNLRED--------------LASKQKQLLKEQKELEELLGHQVVLK 228
+ LR++ +K + LR ++++ LKE+++L Q + +
Sbjct: 1351 QPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQ 1410
Query: 229 DEVAHHQTIPVQIGKEIEKITRKKVE-----MEKKKIVLEQEVKTLNDSLKKVENKVSAI 283
D + Q+ ++ ++ E E+++ LE+E + + +K + +
Sbjct: 1411 DRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLL 1470
Query: 284 VDEKENVIKEVEGKRALLE----IKEREHNQLVKLLEL-ARENEATSLTERGIL--DLNL 336
+ +E + E R LE ++ +E ++ + EL ++E E L E L
Sbjct: 1471 QEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQ 1530
Query: 337 RNSLIDKQNYHDELSRKQREKERDFRNLRKMELLLKVSWDALRQTQALHQRLLLEMEAIP 396
R L ++Q + +QR ++RD R R+ E L + + Q ++ LE + +
Sbjct: 1531 RKFLQEEQQLRRQERGQQRRQDRD-RKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVR 1589
Query: 397 KDDSTLSERRRELHKEVEVAKRNLAQQKIISEMESKLVEQ----QLAEENKLLKEQENMK 452
+ E+ R+ ++ + +R QQ++ E + K E Q EE +L +++ + K
Sbjct: 1590 R-----QEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRK 1644
Query: 453 ELVVNLLRMTQIKIDEKEQ-----KSKDFLKAQQKYTNIVKEMKAKDLEIRIHKKKKCEI 507
L Q++ E+EQ + + F + +Q ++ + R ++++ ++
Sbjct: 1645 FLE----EEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQL 1700
Query: 508 YRRLREFAKLYDTIRNERNKFVNLLHKAHQKVNEI-------KERHKMSLNELEILRNSA 560
R+ RE L + + R + + Q E +ER++ L E E LR
Sbjct: 1701 RRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEE-EQLRPER 1759
Query: 561 VSQERKLQNSMLKHANNVTIRES-------MQNDVRKIVSKLQEMKEKKEAQLNNIDRLA 613
Q+ + Q K +R+ Q RK + Q +E++E QL R
Sbjct: 1760 EEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQR-- 1817
Query: 614 NTITMIEEEMVQL-----RKRYEKAVQHRNES--GVQLIEREEEICIFYEKINIQEKMKL 666
+ EEE +QL R R E+ Q+R E Q R EE +++ +E+ K
Sbjct: 1818 DGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREE-----QELWQEEEQKR 1872
Query: 667 NGEIEIHLLEEKIQFLKMKIAEKQRQI 693
E E L EE I+ + K ++ RQ+
Sbjct: 1873 RQERERKLREEHIR-RQQKEEQRHRQV 1898
Score = 33.9 bits (76), Expect = 0.75
Identities = 32/179 (17%), Positives = 80/179 (44%), Gaps = 8/179 (4%)
Query: 82 QESEVQLLQNAKRFTEQIQ------QQQFHLQQADN-FPEAFSTEVSKMREQLLKYQNEY 134
+E +++ + ++F E+ Q +QQ Q++D F E + +QL Q +
Sbjct: 1760 EEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDG 1819
Query: 135 N-AVKEREFHNQYRLNSLKEEKIIIVKEFEKITKPGEMEKKMKILRESTEELRKEIMQKK 193
+E + + + L++E+ + E+ + ++ + L + E+ R++ ++K
Sbjct: 1820 KYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERK 1879
Query: 194 LEIKNLREDLASKQKQLLKEQKELEELLGHQVVLKDEVAHHQTIPVQIGKEIEKITRKK 252
L +++R +Q+ + + +E GH +L+ ++PV+ E I ++
Sbjct: 1880 LREEHIRRQQKEEQRHRQVGEIKSQEGKGHGRLLEPGTHQFASVPVRSSPLYEYIQEQR 1938
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.130 0.341
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,994,769
Number of Sequences: 37866
Number of extensions: 1504226
Number of successful extensions: 21939
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 324
Number of HSP's successfully gapped in prelim test: 1148
Number of HSP's that attempted gapping in prelim test: 10694
Number of HSP's gapped (non-prelim): 6089
length of query: 955
length of database: 18,247,518
effective HSP length: 112
effective length of query: 843
effective length of database: 14,006,526
effective search space: 11807501418
effective search space used: 11807501418
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.