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Search of human proteins with 186910317
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|186910317 solute carrier family 12, member 3 isoform 2 [Homo
sapiens]
(1029 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|186910317 solute carrier family 12, member 3 isoform 2 [Homo ... 2081 0.0
gi|186910315 solute carrier family 12, member 3 isoform 1 [Homo ... 2076 0.0
gi|186910319 solute carrier family 12, member 3 isoform 3 [Homo ... 2050 0.0
gi|4506975 solute carrier family 12 (sodium/potassium/chloride t... 1072 0.0
gi|134254459 sodium potassium chloride cotransporter 2 [Homo sap... 1061 0.0
gi|31881740 solute carrier family 12 (potassium/chloride transpo... 248 2e-65
gi|110224458 solute carrier family 12, member 6 isoform e [Homo ... 236 1e-61
gi|110224456 solute carrier family 12, member 6 isoform d [Homo ... 236 1e-61
gi|110224454 solute carrier family 12, member 6 isoform c [Homo ... 236 1e-61
gi|110224452 solute carrier family 12, member 6 isoform c [Homo ... 236 1e-61
gi|4826780 solute carrier family 12, member 6 isoform b [Homo sa... 236 1e-61
gi|110224449 solute carrier family 12, member 6 isoform a [Homo ... 236 1e-61
gi|123701900 solute carrier family 12 (potassium/chloride transp... 234 3e-61
gi|225579061 solute carrier family 12, member 4 isoform b [Homo ... 233 7e-61
gi|225579067 solute carrier family 12, member 4 isoform e [Homo ... 231 3e-60
gi|225579065 solute carrier family 12, member 4 isoform d [Homo ... 231 3e-60
gi|225579063 solute carrier family 12, member 4 isoform c [Homo ... 231 3e-60
gi|4827006 solute carrier family 12, member 4 isoform a [Homo sa... 231 3e-60
gi|38569457 solute carrier family 12, member 8 [Homo sapiens] 224 2e-58
gi|198041678 solute carrier family 12 (potassium-chloride transp... 222 2e-57
gi|11968148 solute carrier family 12 (potassium-chloride transpo... 222 2e-57
gi|55743077 ATPase, class I, type 8B, member 2 isoform b [Homo s... 36 0.21
gi|134304858 solute carrier family 7, member 2 isoform 2 [Homo s... 35 0.48
gi|7657683 solute carrier family 7, (cationic amino acid transpo... 33 1.8
gi|239740773 PREDICTED: similar to diffuse panbronchiolitis crit... 32 2.4
gi|6005715 solute carrier family 6 (amino acid transporter), mem... 32 3.1
gi|109948288 solute carrier family 7, member 2 isoform 1 [Homo s... 32 4.0
gi|153792564 solute carrier family 47, member 2 isoform 2 [Homo ... 31 6.9
gi|38261960 solute carrier family 47, member 2 isoform 1 [Homo s... 31 6.9
gi|203098995 solute carrier family 2 (facilitated glucose transp... 30 9.0
>gi|186910317 solute carrier family 12, member 3 isoform 2 [Homo
sapiens]
Length = 1029
Score = 2081 bits (5391), Expect = 0.0
Identities = 1029/1029 (100%), Positives = 1029/1029 (100%)
Query: 1 MAELPTTETPGDATLCSGRFTISTLLSSDEPSPPAAYDSSHPSHLTHSSTFCMRTFGYNT 60
MAELPTTETPGDATLCSGRFTISTLLSSDEPSPPAAYDSSHPSHLTHSSTFCMRTFGYNT
Sbjct: 1 MAELPTTETPGDATLCSGRFTISTLLSSDEPSPPAAYDSSHPSHLTHSSTFCMRTFGYNT 60
Query: 61 IDVVPTYEHYANSTQPGEPRKVRPTLADLHSFLKEGRHLHALAFDSRPSHEMTDGLVEGE 120
IDVVPTYEHYANSTQPGEPRKVRPTLADLHSFLKEGRHLHALAFDSRPSHEMTDGLVEGE
Sbjct: 61 IDVVPTYEHYANSTQPGEPRKVRPTLADLHSFLKEGRHLHALAFDSRPSHEMTDGLVEGE 120
Query: 121 AGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLSVTV 180
AGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLSVTV
Sbjct: 121 AGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLSVTV 180
Query: 181 TSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAET 240
TSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAET
Sbjct: 181 TSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAET 240
Query: 241 VRDLLQEYGAPIVDPINDIRIIGVVSVTVLLAISLAGMEWESKAQVLFFLVIMVSFANYL 300
VRDLLQEYGAPIVDPINDIRIIGVVSVTVLLAISLAGMEWESKAQVLFFLVIMVSFANYL
Sbjct: 241 VRDLLQEYGAPIVDPINDIRIIGVVSVTVLLAISLAGMEWESKAQVLFFLVIMVSFANYL 300
Query: 301 VGTLIPPSEDKASKGFFSYRADIFVQNLVPDWRGPDGTFFGMFSIFFPSATGILAGANIS 360
VGTLIPPSEDKASKGFFSYRADIFVQNLVPDWRGPDGTFFGMFSIFFPSATGILAGANIS
Sbjct: 301 VGTLIPPSEDKASKGFFSYRADIFVQNLVPDWRGPDGTFFGMFSIFFPSATGILAGANIS 360
Query: 361 GDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSCVVRDASGVLNDTVTPGWGACEGLAC 420
GDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSCVVRDASGVLNDTVTPGWGACEGLAC
Sbjct: 361 GDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSCVVRDASGVLNDTVTPGWGACEGLAC 420
Query: 421 SYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAPLITAGIFGATLSSALACLVSAAKVFQ 480
SYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAPLITAGIFGATLSSALACLVSAAKVFQ
Sbjct: 421 SYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAPLITAGIFGATLSSALACLVSAAKVFQ 480
Query: 481 CLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAVAFIIIAELNTIAPIISNFFLCSYA 540
CLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAVAFIIIAELNTIAPIISNFFLCSYA
Sbjct: 481 CLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAVAFIIIAELNTIAPIISNFFLCSYA 540
Query: 541 LINFSCFHASITNSPGWRPSFQYYNKWAALFGAIISVVIMFLLTWWAALIAIGVVLFLLL 600
LINFSCFHASITNSPGWRPSFQYYNKWAALFGAIISVVIMFLLTWWAALIAIGVVLFLLL
Sbjct: 541 LINFSCFHASITNSPGWRPSFQYYNKWAALFGAIISVVIMFLLTWWAALIAIGVVLFLLL 600
Query: 601 YVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDHIKNYRPQCLVLTGPPNFRPALVDF 660
YVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDHIKNYRPQCLVLTGPPNFRPALVDF
Sbjct: 601 YVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDHIKNYRPQCLVLTGPPNFRPALVDF 660
Query: 661 VGTFTRNLSLMICGHVLIGPHKQRMPELQLIANGHTKWLNKRKIKAFYSDVIAEDLRRGV 720
VGTFTRNLSLMICGHVLIGPHKQRMPELQLIANGHTKWLNKRKIKAFYSDVIAEDLRRGV
Sbjct: 661 VGTFTRNLSLMICGHVLIGPHKQRMPELQLIANGHTKWLNKRKIKAFYSDVIAEDLRRGV 720
Query: 721 QILMQAAGLGRMKPNILVVGFKKNWQSAHPATVEDYIGILHDAFDFNYGVCVMRMREGLN 780
QILMQAAGLGRMKPNILVVGFKKNWQSAHPATVEDYIGILHDAFDFNYGVCVMRMREGLN
Sbjct: 721 QILMQAAGLGRMKPNILVVGFKKNWQSAHPATVEDYIGILHDAFDFNYGVCVMRMREGLN 780
Query: 781 VSKMMQAHINPVFDPAEDGKEASARGARPSVSGALDPKALVKEEQATTIFQSEQGKKTID 840
VSKMMQAHINPVFDPAEDGKEASARGARPSVSGALDPKALVKEEQATTIFQSEQGKKTID
Sbjct: 781 VSKMMQAHINPVFDPAEDGKEASARGARPSVSGALDPKALVKEEQATTIFQSEQGKKTID 840
Query: 841 IYWLFDDGGLTLLIPYLLGRKRRWSKCKIRVFVGGQINRMDQERKAIISLLSKFRLGFHE 900
IYWLFDDGGLTLLIPYLLGRKRRWSKCKIRVFVGGQINRMDQERKAIISLLSKFRLGFHE
Sbjct: 841 IYWLFDDGGLTLLIPYLLGRKRRWSKCKIRVFVGGQINRMDQERKAIISLLSKFRLGFHE 900
Query: 901 VHILPDINQNPRAEHTKRFEDMIAPFRLNDGFKDEATVNEMRRDCPWKISDEEITKNRVK 960
VHILPDINQNPRAEHTKRFEDMIAPFRLNDGFKDEATVNEMRRDCPWKISDEEITKNRVK
Sbjct: 901 VHILPDINQNPRAEHTKRFEDMIAPFRLNDGFKDEATVNEMRRDCPWKISDEEITKNRVK 960
Query: 961 SLRQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLETLSQDLRPPVILIRGNQ 1020
SLRQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLETLSQDLRPPVILIRGNQ
Sbjct: 961 SLRQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLETLSQDLRPPVILIRGNQ 1020
Query: 1021 ENVLTFYCQ 1029
ENVLTFYCQ
Sbjct: 1021 ENVLTFYCQ 1029
>gi|186910315 solute carrier family 12, member 3 isoform 1 [Homo
sapiens]
Length = 1030
Score = 2076 bits (5379), Expect = 0.0
Identities = 1029/1030 (99%), Positives = 1029/1030 (99%), Gaps = 1/1030 (0%)
Query: 1 MAELPTTETPGDATLCSGRFTISTLLSSDEPSPPAAYDSSHPSHLTHSSTFCMRTFGYNT 60
MAELPTTETPGDATLCSGRFTISTLLSSDEPSPPAAYDSSHPSHLTHSSTFCMRTFGYNT
Sbjct: 1 MAELPTTETPGDATLCSGRFTISTLLSSDEPSPPAAYDSSHPSHLTHSSTFCMRTFGYNT 60
Query: 61 IDVVPTYEHYANSTQPGEPRKVRPTLADLHSFLK-EGRHLHALAFDSRPSHEMTDGLVEG 119
IDVVPTYEHYANSTQPGEPRKVRPTLADLHSFLK EGRHLHALAFDSRPSHEMTDGLVEG
Sbjct: 61 IDVVPTYEHYANSTQPGEPRKVRPTLADLHSFLKQEGRHLHALAFDSRPSHEMTDGLVEG 120
Query: 120 EAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLSVT 179
EAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLSVT
Sbjct: 121 EAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLSVT 180
Query: 180 VTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAE 239
VTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAE
Sbjct: 181 VTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAE 240
Query: 240 TVRDLLQEYGAPIVDPINDIRIIGVVSVTVLLAISLAGMEWESKAQVLFFLVIMVSFANY 299
TVRDLLQEYGAPIVDPINDIRIIGVVSVTVLLAISLAGMEWESKAQVLFFLVIMVSFANY
Sbjct: 241 TVRDLLQEYGAPIVDPINDIRIIGVVSVTVLLAISLAGMEWESKAQVLFFLVIMVSFANY 300
Query: 300 LVGTLIPPSEDKASKGFFSYRADIFVQNLVPDWRGPDGTFFGMFSIFFPSATGILAGANI 359
LVGTLIPPSEDKASKGFFSYRADIFVQNLVPDWRGPDGTFFGMFSIFFPSATGILAGANI
Sbjct: 301 LVGTLIPPSEDKASKGFFSYRADIFVQNLVPDWRGPDGTFFGMFSIFFPSATGILAGANI 360
Query: 360 SGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSCVVRDASGVLNDTVTPGWGACEGLA 419
SGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSCVVRDASGVLNDTVTPGWGACEGLA
Sbjct: 361 SGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSCVVRDASGVLNDTVTPGWGACEGLA 420
Query: 420 CSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAPLITAGIFGATLSSALACLVSAAKVF 479
CSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAPLITAGIFGATLSSALACLVSAAKVF
Sbjct: 421 CSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAPLITAGIFGATLSSALACLVSAAKVF 480
Query: 480 QCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAVAFIIIAELNTIAPIISNFFLCSY 539
QCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAVAFIIIAELNTIAPIISNFFLCSY
Sbjct: 481 QCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAVAFIIIAELNTIAPIISNFFLCSY 540
Query: 540 ALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIISVVIMFLLTWWAALIAIGVVLFLL 599
ALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIISVVIMFLLTWWAALIAIGVVLFLL
Sbjct: 541 ALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIISVVIMFLLTWWAALIAIGVVLFLL 600
Query: 600 LYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDHIKNYRPQCLVLTGPPNFRPALVD 659
LYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDHIKNYRPQCLVLTGPPNFRPALVD
Sbjct: 601 LYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDHIKNYRPQCLVLTGPPNFRPALVD 660
Query: 660 FVGTFTRNLSLMICGHVLIGPHKQRMPELQLIANGHTKWLNKRKIKAFYSDVIAEDLRRG 719
FVGTFTRNLSLMICGHVLIGPHKQRMPELQLIANGHTKWLNKRKIKAFYSDVIAEDLRRG
Sbjct: 661 FVGTFTRNLSLMICGHVLIGPHKQRMPELQLIANGHTKWLNKRKIKAFYSDVIAEDLRRG 720
Query: 720 VQILMQAAGLGRMKPNILVVGFKKNWQSAHPATVEDYIGILHDAFDFNYGVCVMRMREGL 779
VQILMQAAGLGRMKPNILVVGFKKNWQSAHPATVEDYIGILHDAFDFNYGVCVMRMREGL
Sbjct: 721 VQILMQAAGLGRMKPNILVVGFKKNWQSAHPATVEDYIGILHDAFDFNYGVCVMRMREGL 780
Query: 780 NVSKMMQAHINPVFDPAEDGKEASARGARPSVSGALDPKALVKEEQATTIFQSEQGKKTI 839
NVSKMMQAHINPVFDPAEDGKEASARGARPSVSGALDPKALVKEEQATTIFQSEQGKKTI
Sbjct: 781 NVSKMMQAHINPVFDPAEDGKEASARGARPSVSGALDPKALVKEEQATTIFQSEQGKKTI 840
Query: 840 DIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRVFVGGQINRMDQERKAIISLLSKFRLGFH 899
DIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRVFVGGQINRMDQERKAIISLLSKFRLGFH
Sbjct: 841 DIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRVFVGGQINRMDQERKAIISLLSKFRLGFH 900
Query: 900 EVHILPDINQNPRAEHTKRFEDMIAPFRLNDGFKDEATVNEMRRDCPWKISDEEITKNRV 959
EVHILPDINQNPRAEHTKRFEDMIAPFRLNDGFKDEATVNEMRRDCPWKISDEEITKNRV
Sbjct: 901 EVHILPDINQNPRAEHTKRFEDMIAPFRLNDGFKDEATVNEMRRDCPWKISDEEITKNRV 960
Query: 960 KSLRQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLETLSQDLRPPVILIRGN 1019
KSLRQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLETLSQDLRPPVILIRGN
Sbjct: 961 KSLRQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLETLSQDLRPPVILIRGN 1020
Query: 1020 QENVLTFYCQ 1029
QENVLTFYCQ
Sbjct: 1021 QENVLTFYCQ 1030
>gi|186910319 solute carrier family 12, member 3 isoform 3 [Homo
sapiens]
Length = 1021
Score = 2050 bits (5312), Expect = 0.0
Identities = 1019/1030 (98%), Positives = 1020/1030 (99%), Gaps = 10/1030 (0%)
Query: 1 MAELPTTETPGDATLCSGRFTISTLLSSDEPSPPAAYDSSHPSHLTHSSTFCMRTFGYNT 60
MAELPTTETPGDATLCSGRFTISTLLSSDEPSPPAAYDSSHPSHLTHSSTFCMRTFGYNT
Sbjct: 1 MAELPTTETPGDATLCSGRFTISTLLSSDEPSPPAAYDSSHPSHLTHSSTFCMRTFGYNT 60
Query: 61 IDVVPTYEHYANSTQPGEPRKVRPTLADLHSFLK-EGRHLHALAFDSRPSHEMTDGLVEG 119
IDVVPTYEHYANSTQPGEPRKVRPTLADLHSFLK EGRHLHALAFDSRPSHEMTDGLVEG
Sbjct: 61 IDVVPTYEHYANSTQPGEPRKVRPTLADLHSFLKQEGRHLHALAFDSRPSHEMTDGLVEG 120
Query: 120 EAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLSVT 179
EAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLSVT
Sbjct: 121 EAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLSVT 180
Query: 180 VTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAE 239
VTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAE
Sbjct: 181 VTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAE 240
Query: 240 TVRDLLQEYGAPIVDPINDIRIIGVVSVTVLLAISLAGMEWESKAQVLFFLVIMVSFANY 299
TVRDLLQEYGAPIVDPINDIRIIGVVSVTVLLAISLAGMEWESKAQVLFFLVIMVSFANY
Sbjct: 241 TVRDLLQEYGAPIVDPINDIRIIGVVSVTVLLAISLAGMEWESKAQVLFFLVIMVSFANY 300
Query: 300 LVGTLIPPSEDKASKGFFSYRADIFVQNLVPDWRGPDGTFFGMFSIFFPSATGILAGANI 359
LVGTLIPPSEDKASKGFFSYRADIFVQNLVPDWRGPDGTFFGMFSIFFPSATGILAGANI
Sbjct: 301 LVGTLIPPSEDKASKGFFSYRADIFVQNLVPDWRGPDGTFFGMFSIFFPSATGILAGANI 360
Query: 360 SGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSCVVRDASGVLNDTVTPGWGACEGLA 419
SGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSCVVRDASGVLNDTVTPGWGACEGLA
Sbjct: 361 SGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSCVVRDASGVLNDTVTPGWGACEGLA 420
Query: 420 CSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAPLITAGIFGATLSSALACLVSAAKVF 479
CSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAPLITAGIFGATLSSALACLVSAAKVF
Sbjct: 421 CSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAPLITAGIFGATLSSALACLVSAAKVF 480
Query: 480 QCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAVAFIIIAELNTIAPIISNFFLCSY 539
QCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAVAFIIIAELNTIAPIISNFFLCSY
Sbjct: 481 QCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAVAFIIIAELNTIAPIISNFFLCSY 540
Query: 540 ALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIISVVIMFLLTWWAALIAIGVVLFLL 599
ALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIISVVIMFLLTWWAALIAIGVVLFLL
Sbjct: 541 ALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIISVVIMFLLTWWAALIAIGVVLFLL 600
Query: 600 LYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDHIKNYRPQCLVLTGPPNFRPALVD 659
LYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDHIKNYRPQCLVLTGPPNFRPALVD
Sbjct: 601 LYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDHIKNYRPQCLVLTGPPNFRPALVD 660
Query: 660 FVGTFTRNLSLMICGHVLIGPHKQRMPELQLIANGHTKWLNKRKIKAFYSDVIAEDLRRG 719
FVGTFTRNLSLMICGHVLIGPHKQRMPELQLIANGHTKWLNKRKIKAFYSDVIAEDLRRG
Sbjct: 661 FVGTFTRNLSLMICGHVLIGPHKQRMPELQLIANGHTKWLNKRKIKAFYSDVIAEDLRRG 720
Query: 720 VQILMQAAGLGRMKPNILVVGFKKNWQSAHPATVEDYIGILHDAFDFNYGVCVMRMREGL 779
VQILMQAAGLGRMKPNILVVGFKKNWQSAHPATVEDYIGILHDAFDFNYGVCVMRMREGL
Sbjct: 721 VQILMQAAGLGRMKPNILVVGFKKNWQSAHPATVEDYIGILHDAFDFNYGVCVMRMREGL 780
Query: 780 NVSKMMQAHINPVFDPAEDGKEASARGARPSVSGALDPKALVKEEQATTIFQSEQGKKTI 839
NVSKMMQAHINPVFDPAEDGKEASAR +DPKALVKEEQATTIFQSEQGKKTI
Sbjct: 781 NVSKMMQAHINPVFDPAEDGKEASAR---------VDPKALVKEEQATTIFQSEQGKKTI 831
Query: 840 DIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRVFVGGQINRMDQERKAIISLLSKFRLGFH 899
DIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRVFVGGQINRMDQERKAIISLLSKFRLGFH
Sbjct: 832 DIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRVFVGGQINRMDQERKAIISLLSKFRLGFH 891
Query: 900 EVHILPDINQNPRAEHTKRFEDMIAPFRLNDGFKDEATVNEMRRDCPWKISDEEITKNRV 959
EVHILPDINQNPRAEHTKRFEDMIAPFRLNDGFKDEATVNEMRRDCPWKISDEEITKNRV
Sbjct: 892 EVHILPDINQNPRAEHTKRFEDMIAPFRLNDGFKDEATVNEMRRDCPWKISDEEITKNRV 951
Query: 960 KSLRQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLETLSQDLRPPVILIRGN 1019
KSLRQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLETLSQDLRPPVILIRGN
Sbjct: 952 KSLRQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLETLSQDLRPPVILIRGN 1011
Query: 1020 QENVLTFYCQ 1029
QENVLTFYCQ
Sbjct: 1012 QENVLTFYCQ 1021
>gi|4506975 solute carrier family 12 (sodium/potassium/chloride
transporters), member 2 [Homo sapiens]
Length = 1212
Score = 1072 bits (2773), Expect = 0.0
Identities = 535/1037 (51%), Positives = 727/1037 (70%), Gaps = 66/1037 (6%)
Query: 39 SSHPSHL---THSSTFCMRTFGYNTIDVVPTYEHYANSTQPGEPRKVRPTLADLHSFLKE 95
S H H TH++T+ +RTFG+NT+D VP +HY ++ + +RP+LA+LH L++
Sbjct: 193 SGHHQHYYYDTHTNTYYLRTFGHNTMDAVPRIDHYRHTAAQLGEKLLRPSLAELHDELEK 252
Query: 96 GRHLHALAFDSRPSHEMTDGLVEGEAGTSSEK-------NPEEPVRFGWVKGVMIRCMLN 148
DG GE T + + V+FGW+KGV++RCMLN
Sbjct: 253 --------------EPFEDGFANGEESTPTRDAVVTYTAESKGVVKFGWIKGVLVRCMLN 298
Query: 149 IWGVILYLRLPWITAQAGIVLTWIIILLSVTVTSITGLSISAISTNGKVKSGGTYFLISR 208
IWGV+L++RL WI QAGI L+ ++I+++ VT+ITGLS SAI+TNG V+ GG Y+LISR
Sbjct: 299 IWGVMLFIRLSWIVGQAGIGLSVLVIMMATVVTTITGLSTSAIATNGFVRGGGAYYLISR 358
Query: 209 SLGPELGGSIGLIFAFANAVGVAMHTVGFAETVRDLLQEYGAPIVDPINDIRIIGVVSVT 268
SLGPE GG+IGLIFAFANAV VAM+ VGFAETV +LL+E+ ++D INDIRIIG ++V
Sbjct: 359 SLGPEFGGAIGLIFAFANAVAVAMYVVGFAETVVELLKEHSILMIDEINDIRIIGAITVV 418
Query: 269 VLLAISLAGMEWESKAQVLFFLVIMVSFANYLVGTLIPPSEDKASKGFFSYRADIFVQNL 328
+LL IS+AGMEWE+KAQ++ ++++++ ++++GT IP E K KGFF Y+++IF +N
Sbjct: 419 ILLGISVAGMEWEAKAQIVLLVILLLAIGDFVIGTFIP-LESKKPKGFFGYKSEIFNENF 477
Query: 329 VPDWRGPDGTFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAI 388
PD+R + TFF +F+IFFP+ATGILAGANISGDL DP AIPKGTL+AI TT+ Y+ I
Sbjct: 478 GPDFREEE-TFFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTLVYVGI 536
Query: 389 SATIGSCVVRDASGVLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSM 448
+ ++GSCVVRDA+G +NDT+ C AC ++F+ C + C YGL+N +Q MSM
Sbjct: 537 AVSVGSCVVRDATGNVNDTIVTELTNCTSAACKLNFDFSSC-ESSPCSYGLMNNFQVMSM 595
Query: 449 VSGFAPLITAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGY 508
VSGF PLI+AGIF ATLSSALA LVSA K+FQ LC+D +YP F KGYGKN EP+RGY
Sbjct: 596 VSGFTPLISAGIFSATLSSALASLVSAPKIFQALCKDNIYPAFQMFAKGYGKNNEPLRGY 655
Query: 509 LLAYAIAVAFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWA 568
+L + IA+ FI+IAELN IAPIISNFFL SYALINFS FHAS+ SPGWRP+F+YYN W
Sbjct: 656 ILTFLIALGFILIAELNVIAPIISNFFLASYALINFSVFHASLAKSPGWRPAFKYYNMWI 715
Query: 569 ALFGAIISVVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSV 628
+L GAI+ ++MF++ WWAAL+ +VL L +YV YKKP+VNWGSS QA +Y AL +S+
Sbjct: 716 SLLGAILCCIVMFVINWWAALLTYVIVLGLYIYVTYKKPDVNWGSSTQALTYLNALQHSI 775
Query: 629 GLNEVEDHIKNYRPQCLVLTGPPNFRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPEL 688
L+ VEDH+KN+RPQCLV+TG PN RPAL+ V FT+N+ LMICGHV +GP +Q M E+
Sbjct: 776 RLSGVEDHVKNFRPQCLVMTGAPNSRPALLHLVHDFTKNVGLMICGHVHMGPRRQAMKEM 835
Query: 689 QLIANGHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNWQSA 748
+ + +WL K K+KAFY+ V A+DLR G Q LMQAAGLGRMKPN LV+GFKK+W A
Sbjct: 836 SIDQAKYQRWLIKNKMKAFYAPVHADDLREGAQYLMQAAGLGRMKPNTLVLGFKKDWLQA 895
Query: 749 HPATVEDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAH-------------------- 788
V+ YI + HDAFD YGV V+R++EGL++S +
Sbjct: 896 DMRDVDMYINLFHDAFDIQYGVVVIRLKEGLDISHLQGQEELLSSQEKSPGTKDVVVSVE 955
Query: 789 ---------INPVFD-------PAEDGKEASARGARPSVSGALDPKALVKEE--QATTIF 830
P+ + EDGK A+ + G + P + ++ +A+T F
Sbjct: 956 YSKKSDLDTSKPLSEKPITHKVEEEDGKTATQPLLKKESKGPIVPLNVADQKLLEASTQF 1015
Query: 831 QSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRVFVGGQINRMDQERKAIISL 890
Q +QGK TID++WLFDDGGLTLLIPYLL K++W CKIRVF+GG+INR+D +R+A+ +L
Sbjct: 1016 QKKQGKNTIDVWWLFDDGGLTLLIPYLLTTKKKWKDCKIRVFIGGKINRIDHDRRAMATL 1075
Query: 891 LSKFRLGFHEVHILPDINQNPRAEHTKRFEDMIAPFRLNDGFKDEATVNEMRRDCPWKIS 950
LSKFR+ F ++ +L DIN P+ E+ FE++I P+RL++ K++ ++M+ D PW+I+
Sbjct: 1076 LSKFRIDFSDIMVLGDINTKPKKENIIAFEEIIEPYRLHEDDKEQDIADKMKEDEPWRIT 1135
Query: 951 DEEITKNRVKSLRQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLETLSQDLR 1010
D E+ + K+ RQ+RLNE++ ++S A +IV++LP+ RKG S+LYMAWLE LS+DL
Sbjct: 1136 DNELELYKTKTYRQIRLNELLKEHSSTANIIVMSLPVARKGAVSSALYMAWLEALSKDL- 1194
Query: 1011 PPVILIRGNQENVLTFY 1027
PP++L+RGN ++VLTFY
Sbjct: 1195 PPILLVRGNHQSVLTFY 1211
>gi|134254459 sodium potassium chloride cotransporter 2 [Homo sapiens]
Length = 1099
Score = 1061 bits (2744), Expect = 0.0
Identities = 533/1025 (52%), Positives = 720/1025 (70%), Gaps = 38/1025 (3%)
Query: 35 AAYDSSHPSHLTHSSTFCMRTFGYNTIDVVPTYEHYANSTQPGEPRKVRPTLADLHSFLK 94
A D+S ++ +H++T+ ++TFG+NT+D VP E+Y N+ P+ RP+L ++H L
Sbjct: 80 AKTDASFHAYDSHTNTYYLQTFGHNTMDAVPKIEYYRNTGSISGPKVNRPSLLEIHEQLA 139
Query: 95 EGRHLHALAFDSRPSHEMTDGLVEGEAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVIL 154
+ A+ S DG+ E + E + V+FGWVKGV++RCMLNIWGV+L
Sbjct: 140 KNV---AVTPSSADRVANGDGIPGDEQAENKEDDQAGVVKFGWVKGVLVRCMLNIWGVML 196
Query: 155 YLRLPWITAQAGIVLTWIIILLSVTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPEL 214
++RL WI +AGI L +IILLS VTSITGLS SAI+TNG V+ GG Y+LISRSLGPE
Sbjct: 197 FIRLSWIVGEAGIGLGVLIILLSTMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPEF 256
Query: 215 GGSIGLIFAFANAVGVAMHTVGFAETVRDLLQEYGAPIVDPINDIRIIGVVSVTVLLAIS 274
GGSIGLIFAFANAV VAM+ VGFAETV DLL+E + +VDP NDIRIIG ++V +LL IS
Sbjct: 257 GGSIGLIFAFANAVAVAMYVVGFAETVVDLLKESDSMMVDPTNDIRIIGSITVVILLGIS 316
Query: 275 LAGMEWESKAQVLFFLVIMVSFANYLVGTLIPPSEDKASKGFFSYRADIFVQNLVPDWRG 334
+AGMEWE+KAQV+ ++++++ AN+ +GT+IP + +K S+GFF+Y+A IF +N P +
Sbjct: 317 VAGMEWEAKAQVILLVILLIAIANFFIGTVIPSNNEKKSRGFFNYQASIFAENFGPRFTK 376
Query: 335 PDGTFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGS 394
+G FF +F+IFFP+ATGILAGANISGDL+DP AIP+GT++AIF TT++YL ++ +G+
Sbjct: 377 GEG-FFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYLGVAICVGA 435
Query: 395 CVVRDASGVLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAP 454
CVVRDA+G +NDT+ G AC G++F+ C + C YGL+N +Q MSMVSGF P
Sbjct: 436 CVVRDATGNMNDTIISGMNCNGSAACGLGYDFSRCRHE-PCQYGLMNNFQVMSMVSGFGP 494
Query: 455 LITAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAI 514
LITAGIF ATLSSALA LVSA KVFQ LC+D +Y + FF KGYGKN EP+RGY+L + I
Sbjct: 495 LITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGKNNEPLRGYILTFLI 554
Query: 515 AVAFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFGAI 574
A+AFI+IAELNTIAPIISNFFL SYALINFSCFHAS SPGWRP++ YN W +LFGA+
Sbjct: 555 AMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAV 614
Query: 575 ISVVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVE 634
+ +MF++ WWAA+I + FL +YV KKP+VNWGSS QA SY AL ++ L VE
Sbjct: 615 LCCAVMFVINWWAAVITYVIEFFLYVYVTCKKPDVNWGSSTQALSYVSALDNALELTTVE 674
Query: 635 DHIKNYRPQCLVLTGPPNFRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPELQLIANG 694
DH+KN+RPQC+VLTG P RPAL+D FT+N L IC V +GP K + E+
Sbjct: 675 DHVKNFRPQCIVLTGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNSGMAK 734
Query: 695 HTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNWQSAHPATVE 754
WL K KIKAFY+ V A+ R GV+ L+QA+GLGRMKPN LV+G+KKNW+ A +E
Sbjct: 735 KQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRKAPLTEIE 794
Query: 755 DYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAHIN-------------PVFDPAEDGKE 801
+Y+GI+HDAFDF GV ++R+ +G ++S+++Q + D + +
Sbjct: 795 NYVGIIHDAFDFEIGVVIVRISQGFDISQVLQVQEELERLEQERLALEATIKDNECEEES 854
Query: 802 ASARG------------ARPSVSGALDPKALV-------KEEQATTIFQSEQGKKTIDIY 842
RG P G+++ + K +A+T F+ +Q K TID++
Sbjct: 855 GGIRGLFKKAGKLNITKTTPKKDGSINTSQSMHVGEFNQKLVEASTQFKKKQEKGTIDVW 914
Query: 843 WLFDDGGLTLLIPYLLGRKRRWSKCKIRVFVGGQINRMDQERKAIISLLSKFRLGFHEVH 902
WLFDDGGLTLLIPY+L +++W CK+R++VGG+INR+++E+ + SLLSKFR+ F ++H
Sbjct: 915 WLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGGKINRIEEEKIVMASLLSKFRIKFADIH 974
Query: 903 ILPDINQNPRAEHTKRFEDMIAPFRLNDGFKDEATVNEMRRDCPWKISDEEITKNRVKSL 962
I+ DIN P E K FE+MI P+RL++ KD T +++R+ PWKI+D E+ + KS
Sbjct: 975 IIGDINIRPNKESWKVFEEMIEPYRLHESCKDLTTAEKLKRETPWKITDAELEAVKEKSY 1034
Query: 963 RQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLETLSQDLRPPVILIRGNQEN 1022
RQVRLNE++ ++SR A LIV++LP+ RKG LYMAWLE L+++L PPV+L+RGN +N
Sbjct: 1035 RQVRLNELLQEHSRAANLIVLSLPVARKGSISDLLYMAWLEILTKNL-PPVLLVRGNHKN 1093
Query: 1023 VLTFY 1027
VLTFY
Sbjct: 1094 VLTFY 1098
>gi|31881740 solute carrier family 12 (potassium/chloride
transporters), member 9 [Homo sapiens]
Length = 914
Score = 248 bits (634), Expect = 2e-65
Identities = 173/639 (27%), Positives = 320/639 (50%), Gaps = 86/639 (13%)
Query: 140 GVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLSVTVTSITGLSISAISTNGKVKS 199
GV++ +L+++ ++++LR+ ++ AG++ ++L++ + ++T LS+ AI+TNG V+
Sbjct: 42 GVVVPTVLSMFSIVVFLRIGFVVGHAGLLQALAMLLVAYFILALTVLSVCAIATNGAVQG 101
Query: 200 GGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAETVRDLLQEYGAPIVDPINDI 259
GG YF+ISR+LGPE+GGSIGL+F AN G A+ +G E+V D+ +GA P + +
Sbjct: 102 GGAYFMISRTLGPEVGGSIGLMFYLANVCGCAVSLLGLVESVLDV---FGADATGP-SGL 157
Query: 260 RII----------GVVSVTVLLAISLAGMEWESKAQVLFFLVIMVSFANYLV-------- 301
R++ G + + ++ + G ++A L FL++ S A+ L+
Sbjct: 158 RVLPQGYGWNLLYGSLLLGLVGGVCTLGAGLYARASFLTFLLVSGSLASVLISFVAVGPR 217
Query: 302 -----------GTLIPPSEDKASKGFFSYRADIFVQNLVPDW-----RGPDGTFFGMFSI 345
G+ +PP F + + NL + G F +F++
Sbjct: 218 DIRLTPRPGPNGSSLPPRFGH----FTGFNSSTLKDNLGAGYAEDYTTGAVMNFASVFAV 273
Query: 346 FFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSCVVRDASGVLN 405
F TGI+AGAN+SG+LKDP+ AIP GT++A+ +T Y+ + S D + +
Sbjct: 274 LFNGCTGIMAGANMSGELKDPSRAIPLGTIVAVAYTFFVYVLLFFL--SSFTCDRTLLQE 331
Query: 406 DTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAPLITAGIFGATL 465
D YG +++ +S+ + PL+ GI+ L
Sbjct: 332 D---------------YG------------------FFRAISL---WPPLVLIGIYATAL 355
Query: 466 SSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAVAFIIIAELN 525
S++++ L+ A+++ L D L+ +I K + P L ++ + ++ +LN
Sbjct: 356 SASMSSLIGASRILHALARDDLFGVILAPAKVVSRGGNPWAAVLYSWGLVQLVLLAGKLN 415
Query: 526 TIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIISVVIMFLLTW 585
T+A +++ F+L +YA ++ SC ++P +RP+F ++ L G +++MFL++
Sbjct: 416 TLAAVVTVFYLVAYAAVDLSCLSLEWASAPNFRPTFSLFSWHTCLLGVASCLLMMFLISP 475
Query: 586 WAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDHIKNYRPQCL 645
AA ++ ++ L + + +WG QA ++ Y + L+ +DH+K +RPQ L
Sbjct: 476 GAAGGSLLLMGLLAALLTARGGPSSWGYVSQALLFHQVRKYLLRLDVRKDHVKFWRPQLL 535
Query: 646 VLTGPPNFRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPELQLIANGHTKWL---NKR 702
+L G P L+ + L + GHV +G +P + + WL ++
Sbjct: 536 LLVGNPRGALPLLRLANQLKKG-GLYVLGHVTLG-DLDSLPS-DPVQPQYGAWLSLVDRA 592
Query: 703 KIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGF 741
++KAF ++ +R+G Q L++ +GLG MKPN LV+GF
Sbjct: 593 QVKAFVDLTLSPSVRQGAQHLLRISGLGGMKPNTLVLGF 631
>gi|110224458 solute carrier family 12, member 6 isoform e [Homo
sapiens]
Length = 1135
Score = 236 bits (601), Expect = 1e-61
Identities = 199/752 (26%), Positives = 328/752 (43%), Gaps = 148/752 (19%)
Query: 338 TFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSC-- 395
+F + IFFPS TGI+AG+N SGDLKD +IP GT++AI T+ YL+ G+C
Sbjct: 469 SFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIE 528
Query: 396 --VVRDASG-VLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGF 452
V+RD G + + G T+S S +
Sbjct: 529 GVVLRDKFGDAVKGNLVVG---------------------------------TLSWPSPW 555
Query: 453 APLITAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAY 512
+I G F +T + L L A ++ Q + +D + P + FG N EP LL
Sbjct: 556 --VIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKA-NGEPTWALLLTA 612
Query: 513 AIAVAFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFG 572
AIA I+IA L+ +API+S FFL Y +N +C ++ +P WRP F+YY+ + G
Sbjct: 613 AIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMG 672
Query: 573 AIISVVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNE 632
I + +MF+ +W+ A++A+ + + Y+ Y+ E WG ++ S + A + L E
Sbjct: 673 MSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEE 732
Query: 633 VEDHIKNYRPQCLVLTGPPN----FRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPEL 688
H KN+RPQ LVL P L+ F L I G V++G + E
Sbjct: 733 GPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEA 792
Query: 689 QLIANGHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNWQSA 748
+ K+K F V+A LR G+ L+Q+ GLG MK N +V+G+ W+ +
Sbjct: 793 LAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQS 852
Query: 749 HPATV-EDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAHINPVFDPAEDGKEASARGA 807
A + +IG +R+ +++ ++ +I+ F P
Sbjct: 853 EDARAWKTFIG-------------TVRVTTAAHLALLVAKNIS--FFP------------ 885
Query: 808 RPSVSGALDPKALVKEEQATTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWSKC 867
+ + Q +G ID++W+ DGG+ +L+P+LL + + W KC
Sbjct: 886 -------------------SNVEQFSEG--NIDVWWIVHDGGMLMLLPFLLKQHKVWRKC 924
Query: 868 KIRVFVGGQI-NRMDQERKAIISLLSKFRLGFHEVHILPDINQNPRA---EHTKRFE--- 920
IR+F Q+ + Q +K + + L R+ EV ++ + + A E T E
Sbjct: 925 SIRIFTVAQLEDNSIQMKKDLATFLYHLRIE-AEVEVVEMHDSDISAYTYERTLMMEQRS 983
Query: 921 DMIAPFRLNDGFKDEATVNEMRRDCPWKIS------DEEI-----------TKNRVKSLR 963
M+ RL+ +D R+ +++ DEE TK++ + R
Sbjct: 984 QMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASR 1043
Query: 964 ----------------------------QVRLNEIVLDYSRDAALIVITLPIGRKGKCPS 995
V+LNE++++ S +A L+++ +P +
Sbjct: 1044 GQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGD 1103
Query: 996 SLYMAWLETLSQDLRPPVILIRGNQENVLTFY 1027
YM +LE L++ L V+L+RG V+T Y
Sbjct: 1104 ENYMEFLEVLTEGLE-RVLLVRGGGSEVITIY 1134
Score = 123 bits (308), Expect = 1e-27
Identities = 69/207 (33%), Positives = 112/207 (54%), Gaps = 21/207 (10%)
Query: 118 EGEAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLS 177
E E T +K P + + G GV + C+ NI+GVIL+LRL W+ AG++ + I+L+
Sbjct: 153 EAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLIC 212
Query: 178 VTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGF 237
T +T +S+SAI+TNG V +GG+YF+ISR+LGPE GG++GL F AM+ +G
Sbjct: 213 CCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGA 272
Query: 238 AETV-------------RDLLQEYGAPIVDPINDIRIIGVVSVTVLLAISLAGMEWESKA 284
E D L+E A +N++R+ G + +++ + G+ + +K
Sbjct: 273 IEIFLVYIVPRAAIFHSDDALKESAA----MLNNMRVYGTAFLVLMVLVVFIGVRYVNKF 328
Query: 285 QVLFFLVIMVS----FANYLVGTLIPP 307
LF ++VS +A + + PP
Sbjct: 329 ASLFLACVIVSILAIYAGAIKSSFAPP 355
>gi|110224456 solute carrier family 12, member 6 isoform d [Homo
sapiens]
Length = 1141
Score = 236 bits (601), Expect = 1e-61
Identities = 199/752 (26%), Positives = 328/752 (43%), Gaps = 148/752 (19%)
Query: 338 TFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSC-- 395
+F + IFFPS TGI+AG+N SGDLKD +IP GT++AI T+ YL+ G+C
Sbjct: 475 SFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIE 534
Query: 396 --VVRDASG-VLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGF 452
V+RD G + + G T+S S +
Sbjct: 535 GVVLRDKFGDAVKGNLVVG---------------------------------TLSWPSPW 561
Query: 453 APLITAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAY 512
+I G F +T + L L A ++ Q + +D + P + FG N EP LL
Sbjct: 562 --VIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKA-NGEPTWALLLTA 618
Query: 513 AIAVAFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFG 572
AIA I+IA L+ +API+S FFL Y +N +C ++ +P WRP F+YY+ + G
Sbjct: 619 AIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMG 678
Query: 573 AIISVVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNE 632
I + +MF+ +W+ A++A+ + + Y+ Y+ E WG ++ S + A + L E
Sbjct: 679 MSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEE 738
Query: 633 VEDHIKNYRPQCLVLTGPPN----FRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPEL 688
H KN+RPQ LVL P L+ F L I G V++G + E
Sbjct: 739 GPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEA 798
Query: 689 QLIANGHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNWQSA 748
+ K+K F V+A LR G+ L+Q+ GLG MK N +V+G+ W+ +
Sbjct: 799 LAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQS 858
Query: 749 HPATV-EDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAHINPVFDPAEDGKEASARGA 807
A + +IG +R+ +++ ++ +I+ F P
Sbjct: 859 EDARAWKTFIG-------------TVRVTTAAHLALLVAKNIS--FFP------------ 891
Query: 808 RPSVSGALDPKALVKEEQATTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWSKC 867
+ + Q +G ID++W+ DGG+ +L+P+LL + + W KC
Sbjct: 892 -------------------SNVEQFSEG--NIDVWWIVHDGGMLMLLPFLLKQHKVWRKC 930
Query: 868 KIRVFVGGQI-NRMDQERKAIISLLSKFRLGFHEVHILPDINQNPRA---EHTKRFE--- 920
IR+F Q+ + Q +K + + L R+ EV ++ + + A E T E
Sbjct: 931 SIRIFTVAQLEDNSIQMKKDLATFLYHLRIE-AEVEVVEMHDSDISAYTYERTLMMEQRS 989
Query: 921 DMIAPFRLNDGFKDEATVNEMRRDCPWKIS------DEEI-----------TKNRVKSLR 963
M+ RL+ +D R+ +++ DEE TK++ + R
Sbjct: 990 QMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASR 1049
Query: 964 ----------------------------QVRLNEIVLDYSRDAALIVITLPIGRKGKCPS 995
V+LNE++++ S +A L+++ +P +
Sbjct: 1050 GQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGD 1109
Query: 996 SLYMAWLETLSQDLRPPVILIRGNQENVLTFY 1027
YM +LE L++ L V+L+RG V+T Y
Sbjct: 1110 ENYMEFLEVLTEGLE-RVLLVRGGGSEVITIY 1140
Score = 123 bits (308), Expect = 1e-27
Identities = 69/207 (33%), Positives = 112/207 (54%), Gaps = 21/207 (10%)
Query: 118 EGEAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLS 177
E E T +K P + + G GV + C+ NI+GVIL+LRL W+ AG++ + I+L+
Sbjct: 159 EAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLIC 218
Query: 178 VTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGF 237
T +T +S+SAI+TNG V +GG+YF+ISR+LGPE GG++GL F AM+ +G
Sbjct: 219 CCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGA 278
Query: 238 AETV-------------RDLLQEYGAPIVDPINDIRIIGVVSVTVLLAISLAGMEWESKA 284
E D L+E A +N++R+ G + +++ + G+ + +K
Sbjct: 279 IEIFLVYIVPRAAIFHSDDALKESAA----MLNNMRVYGTAFLVLMVLVVFIGVRYVNKF 334
Query: 285 QVLFFLVIMVS----FANYLVGTLIPP 307
LF ++VS +A + + PP
Sbjct: 335 ASLFLACVIVSILAIYAGAIKSSFAPP 361
>gi|110224454 solute carrier family 12, member 6 isoform c [Homo
sapiens]
Length = 1091
Score = 236 bits (601), Expect = 1e-61
Identities = 199/752 (26%), Positives = 328/752 (43%), Gaps = 148/752 (19%)
Query: 338 TFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSC-- 395
+F + IFFPS TGI+AG+N SGDLKD +IP GT++AI T+ YL+ G+C
Sbjct: 425 SFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIE 484
Query: 396 --VVRDASG-VLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGF 452
V+RD G + + G T+S S +
Sbjct: 485 GVVLRDKFGDAVKGNLVVG---------------------------------TLSWPSPW 511
Query: 453 APLITAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAY 512
+I G F +T + L L A ++ Q + +D + P + FG N EP LL
Sbjct: 512 --VIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKA-NGEPTWALLLTA 568
Query: 513 AIAVAFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFG 572
AIA I+IA L+ +API+S FFL Y +N +C ++ +P WRP F+YY+ + G
Sbjct: 569 AIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMG 628
Query: 573 AIISVVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNE 632
I + +MF+ +W+ A++A+ + + Y+ Y+ E WG ++ S + A + L E
Sbjct: 629 MSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEE 688
Query: 633 VEDHIKNYRPQCLVLTGPPN----FRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPEL 688
H KN+RPQ LVL P L+ F L I G V++G + E
Sbjct: 689 GPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEA 748
Query: 689 QLIANGHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNWQSA 748
+ K+K F V+A LR G+ L+Q+ GLG MK N +V+G+ W+ +
Sbjct: 749 LAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQS 808
Query: 749 HPATV-EDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAHINPVFDPAEDGKEASARGA 807
A + +IG +R+ +++ ++ +I+ F P
Sbjct: 809 EDARAWKTFIG-------------TVRVTTAAHLALLVAKNIS--FFP------------ 841
Query: 808 RPSVSGALDPKALVKEEQATTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWSKC 867
+ + Q +G ID++W+ DGG+ +L+P+LL + + W KC
Sbjct: 842 -------------------SNVEQFSEG--NIDVWWIVHDGGMLMLLPFLLKQHKVWRKC 880
Query: 868 KIRVFVGGQI-NRMDQERKAIISLLSKFRLGFHEVHILPDINQNPRA---EHTKRFE--- 920
IR+F Q+ + Q +K + + L R+ EV ++ + + A E T E
Sbjct: 881 SIRIFTVAQLEDNSIQMKKDLATFLYHLRIE-AEVEVVEMHDSDISAYTYERTLMMEQRS 939
Query: 921 DMIAPFRLNDGFKDEATVNEMRRDCPWKIS------DEEI-----------TKNRVKSLR 963
M+ RL+ +D R+ +++ DEE TK++ + R
Sbjct: 940 QMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASR 999
Query: 964 ----------------------------QVRLNEIVLDYSRDAALIVITLPIGRKGKCPS 995
V+LNE++++ S +A L+++ +P +
Sbjct: 1000 GQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGD 1059
Query: 996 SLYMAWLETLSQDLRPPVILIRGNQENVLTFY 1027
YM +LE L++ L V+L+RG V+T Y
Sbjct: 1060 ENYMEFLEVLTEGLE-RVLLVRGGGSEVITIY 1090
Score = 123 bits (308), Expect = 1e-27
Identities = 69/207 (33%), Positives = 112/207 (54%), Gaps = 21/207 (10%)
Query: 118 EGEAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLS 177
E E T +K P + + G GV + C+ NI+GVIL+LRL W+ AG++ + I+L+
Sbjct: 109 EAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLIC 168
Query: 178 VTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGF 237
T +T +S+SAI+TNG V +GG+YF+ISR+LGPE GG++GL F AM+ +G
Sbjct: 169 CCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGA 228
Query: 238 AETV-------------RDLLQEYGAPIVDPINDIRIIGVVSVTVLLAISLAGMEWESKA 284
E D L+E A +N++R+ G + +++ + G+ + +K
Sbjct: 229 IEIFLVYIVPRAAIFHSDDALKESAA----MLNNMRVYGTAFLVLMVLVVFIGVRYVNKF 284
Query: 285 QVLFFLVIMVS----FANYLVGTLIPP 307
LF ++VS +A + + PP
Sbjct: 285 ASLFLACVIVSILAIYAGAIKSSFAPP 311
>gi|110224452 solute carrier family 12, member 6 isoform c [Homo
sapiens]
Length = 1091
Score = 236 bits (601), Expect = 1e-61
Identities = 199/752 (26%), Positives = 328/752 (43%), Gaps = 148/752 (19%)
Query: 338 TFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSC-- 395
+F + IFFPS TGI+AG+N SGDLKD +IP GT++AI T+ YL+ G+C
Sbjct: 425 SFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIE 484
Query: 396 --VVRDASG-VLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGF 452
V+RD G + + G T+S S +
Sbjct: 485 GVVLRDKFGDAVKGNLVVG---------------------------------TLSWPSPW 511
Query: 453 APLITAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAY 512
+I G F +T + L L A ++ Q + +D + P + FG N EP LL
Sbjct: 512 --VIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKA-NGEPTWALLLTA 568
Query: 513 AIAVAFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFG 572
AIA I+IA L+ +API+S FFL Y +N +C ++ +P WRP F+YY+ + G
Sbjct: 569 AIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMG 628
Query: 573 AIISVVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNE 632
I + +MF+ +W+ A++A+ + + Y+ Y+ E WG ++ S + A + L E
Sbjct: 629 MSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEE 688
Query: 633 VEDHIKNYRPQCLVLTGPPN----FRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPEL 688
H KN+RPQ LVL P L+ F L I G V++G + E
Sbjct: 689 GPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEA 748
Query: 689 QLIANGHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNWQSA 748
+ K+K F V+A LR G+ L+Q+ GLG MK N +V+G+ W+ +
Sbjct: 749 LAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQS 808
Query: 749 HPATV-EDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAHINPVFDPAEDGKEASARGA 807
A + +IG +R+ +++ ++ +I+ F P
Sbjct: 809 EDARAWKTFIG-------------TVRVTTAAHLALLVAKNIS--FFP------------ 841
Query: 808 RPSVSGALDPKALVKEEQATTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWSKC 867
+ + Q +G ID++W+ DGG+ +L+P+LL + + W KC
Sbjct: 842 -------------------SNVEQFSEG--NIDVWWIVHDGGMLMLLPFLLKQHKVWRKC 880
Query: 868 KIRVFVGGQI-NRMDQERKAIISLLSKFRLGFHEVHILPDINQNPRA---EHTKRFE--- 920
IR+F Q+ + Q +K + + L R+ EV ++ + + A E T E
Sbjct: 881 SIRIFTVAQLEDNSIQMKKDLATFLYHLRIE-AEVEVVEMHDSDISAYTYERTLMMEQRS 939
Query: 921 DMIAPFRLNDGFKDEATVNEMRRDCPWKIS------DEEI-----------TKNRVKSLR 963
M+ RL+ +D R+ +++ DEE TK++ + R
Sbjct: 940 QMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASR 999
Query: 964 ----------------------------QVRLNEIVLDYSRDAALIVITLPIGRKGKCPS 995
V+LNE++++ S +A L+++ +P +
Sbjct: 1000 GQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGD 1059
Query: 996 SLYMAWLETLSQDLRPPVILIRGNQENVLTFY 1027
YM +LE L++ L V+L+RG V+T Y
Sbjct: 1060 ENYMEFLEVLTEGLE-RVLLVRGGGSEVITIY 1090
Score = 123 bits (308), Expect = 1e-27
Identities = 69/207 (33%), Positives = 112/207 (54%), Gaps = 21/207 (10%)
Query: 118 EGEAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLS 177
E E T +K P + + G GV + C+ NI+GVIL+LRL W+ AG++ + I+L+
Sbjct: 109 EAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLIC 168
Query: 178 VTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGF 237
T +T +S+SAI+TNG V +GG+YF+ISR+LGPE GG++GL F AM+ +G
Sbjct: 169 CCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGA 228
Query: 238 AETV-------------RDLLQEYGAPIVDPINDIRIIGVVSVTVLLAISLAGMEWESKA 284
E D L+E A +N++R+ G + +++ + G+ + +K
Sbjct: 229 IEIFLVYIVPRAAIFHSDDALKESAA----MLNNMRVYGTAFLVLMVLVVFIGVRYVNKF 284
Query: 285 QVLFFLVIMVS----FANYLVGTLIPP 307
LF ++VS +A + + PP
Sbjct: 285 ASLFLACVIVSILAIYAGAIKSSFAPP 311
>gi|4826780 solute carrier family 12, member 6 isoform b [Homo
sapiens]
Length = 1099
Score = 236 bits (601), Expect = 1e-61
Identities = 199/752 (26%), Positives = 328/752 (43%), Gaps = 148/752 (19%)
Query: 338 TFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSC-- 395
+F + IFFPS TGI+AG+N SGDLKD +IP GT++AI T+ YL+ G+C
Sbjct: 433 SFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIE 492
Query: 396 --VVRDASG-VLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGF 452
V+RD G + + G T+S S +
Sbjct: 493 GVVLRDKFGDAVKGNLVVG---------------------------------TLSWPSPW 519
Query: 453 APLITAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAY 512
+I G F +T + L L A ++ Q + +D + P + FG N EP LL
Sbjct: 520 --VIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKA-NGEPTWALLLTA 576
Query: 513 AIAVAFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFG 572
AIA I+IA L+ +API+S FFL Y +N +C ++ +P WRP F+YY+ + G
Sbjct: 577 AIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMG 636
Query: 573 AIISVVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNE 632
I + +MF+ +W+ A++A+ + + Y+ Y+ E WG ++ S + A + L E
Sbjct: 637 MSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEE 696
Query: 633 VEDHIKNYRPQCLVLTGPPN----FRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPEL 688
H KN+RPQ LVL P L+ F L I G V++G + E
Sbjct: 697 GPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEA 756
Query: 689 QLIANGHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNWQSA 748
+ K+K F V+A LR G+ L+Q+ GLG MK N +V+G+ W+ +
Sbjct: 757 LAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQS 816
Query: 749 HPATV-EDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAHINPVFDPAEDGKEASARGA 807
A + +IG +R+ +++ ++ +I+ F P
Sbjct: 817 EDARAWKTFIG-------------TVRVTTAAHLALLVAKNIS--FFP------------ 849
Query: 808 RPSVSGALDPKALVKEEQATTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWSKC 867
+ + Q +G ID++W+ DGG+ +L+P+LL + + W KC
Sbjct: 850 -------------------SNVEQFSEG--NIDVWWIVHDGGMLMLLPFLLKQHKVWRKC 888
Query: 868 KIRVFVGGQI-NRMDQERKAIISLLSKFRLGFHEVHILPDINQNPRA---EHTKRFE--- 920
IR+F Q+ + Q +K + + L R+ EV ++ + + A E T E
Sbjct: 889 SIRIFTVAQLEDNSIQMKKDLATFLYHLRIE-AEVEVVEMHDSDISAYTYERTLMMEQRS 947
Query: 921 DMIAPFRLNDGFKDEATVNEMRRDCPWKIS------DEEI-----------TKNRVKSLR 963
M+ RL+ +D R+ +++ DEE TK++ + R
Sbjct: 948 QMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASR 1007
Query: 964 ----------------------------QVRLNEIVLDYSRDAALIVITLPIGRKGKCPS 995
V+LNE++++ S +A L+++ +P +
Sbjct: 1008 GQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGD 1067
Query: 996 SLYMAWLETLSQDLRPPVILIRGNQENVLTFY 1027
YM +LE L++ L V+L+RG V+T Y
Sbjct: 1068 ENYMEFLEVLTEGLE-RVLLVRGGGSEVITIY 1098
Score = 123 bits (308), Expect = 1e-27
Identities = 69/207 (33%), Positives = 112/207 (54%), Gaps = 21/207 (10%)
Query: 118 EGEAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLS 177
E E T +K P + + G GV + C+ NI+GVIL+LRL W+ AG++ + I+L+
Sbjct: 117 EAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLIC 176
Query: 178 VTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGF 237
T +T +S+SAI+TNG V +GG+YF+ISR+LGPE GG++GL F AM+ +G
Sbjct: 177 CCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGA 236
Query: 238 AETV-------------RDLLQEYGAPIVDPINDIRIIGVVSVTVLLAISLAGMEWESKA 284
E D L+E A +N++R+ G + +++ + G+ + +K
Sbjct: 237 IEIFLVYIVPRAAIFHSDDALKESAA----MLNNMRVYGTAFLVLMVLVVFIGVRYVNKF 292
Query: 285 QVLFFLVIMVS----FANYLVGTLIPP 307
LF ++VS +A + + PP
Sbjct: 293 ASLFLACVIVSILAIYAGAIKSSFAPP 319
>gi|110224449 solute carrier family 12, member 6 isoform a [Homo
sapiens]
Length = 1150
Score = 236 bits (601), Expect = 1e-61
Identities = 199/752 (26%), Positives = 328/752 (43%), Gaps = 148/752 (19%)
Query: 338 TFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSC-- 395
+F + IFFPS TGI+AG+N SGDLKD +IP GT++AI T+ YL+ G+C
Sbjct: 484 SFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIE 543
Query: 396 --VVRDASG-VLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGF 452
V+RD G + + G T+S S +
Sbjct: 544 GVVLRDKFGDAVKGNLVVG---------------------------------TLSWPSPW 570
Query: 453 APLITAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAY 512
+I G F +T + L L A ++ Q + +D + P + FG N EP LL
Sbjct: 571 --VIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKA-NGEPTWALLLTA 627
Query: 513 AIAVAFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFG 572
AIA I+IA L+ +API+S FFL Y +N +C ++ +P WRP F+YY+ + G
Sbjct: 628 AIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMG 687
Query: 573 AIISVVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNE 632
I + +MF+ +W+ A++A+ + + Y+ Y+ E WG ++ S + A + L E
Sbjct: 688 MSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEE 747
Query: 633 VEDHIKNYRPQCLVLTGPPN----FRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPEL 688
H KN+RPQ LVL P L+ F L I G V++G + E
Sbjct: 748 GPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEA 807
Query: 689 QLIANGHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNWQSA 748
+ K+K F V+A LR G+ L+Q+ GLG MK N +V+G+ W+ +
Sbjct: 808 LAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQS 867
Query: 749 HPATV-EDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAHINPVFDPAEDGKEASARGA 807
A + +IG +R+ +++ ++ +I+ F P
Sbjct: 868 EDARAWKTFIG-------------TVRVTTAAHLALLVAKNIS--FFP------------ 900
Query: 808 RPSVSGALDPKALVKEEQATTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWSKC 867
+ + Q +G ID++W+ DGG+ +L+P+LL + + W KC
Sbjct: 901 -------------------SNVEQFSEG--NIDVWWIVHDGGMLMLLPFLLKQHKVWRKC 939
Query: 868 KIRVFVGGQI-NRMDQERKAIISLLSKFRLGFHEVHILPDINQNPRA---EHTKRFE--- 920
IR+F Q+ + Q +K + + L R+ EV ++ + + A E T E
Sbjct: 940 SIRIFTVAQLEDNSIQMKKDLATFLYHLRIE-AEVEVVEMHDSDISAYTYERTLMMEQRS 998
Query: 921 DMIAPFRLNDGFKDEATVNEMRRDCPWKIS------DEEI-----------TKNRVKSLR 963
M+ RL+ +D R+ +++ DEE TK++ + R
Sbjct: 999 QMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASR 1058
Query: 964 ----------------------------QVRLNEIVLDYSRDAALIVITLPIGRKGKCPS 995
V+LNE++++ S +A L+++ +P +
Sbjct: 1059 GQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGD 1118
Query: 996 SLYMAWLETLSQDLRPPVILIRGNQENVLTFY 1027
YM +LE L++ L V+L+RG V+T Y
Sbjct: 1119 ENYMEFLEVLTEGLE-RVLLVRGGGSEVITIY 1149
Score = 123 bits (308), Expect = 1e-27
Identities = 69/207 (33%), Positives = 112/207 (54%), Gaps = 21/207 (10%)
Query: 118 EGEAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLS 177
E E T +K P + + G GV + C+ NI+GVIL+LRL W+ AG++ + I+L+
Sbjct: 168 EAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLIC 227
Query: 178 VTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGF 237
T +T +S+SAI+TNG V +GG+YF+ISR+LGPE GG++GL F AM+ +G
Sbjct: 228 CCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGA 287
Query: 238 AETV-------------RDLLQEYGAPIVDPINDIRIIGVVSVTVLLAISLAGMEWESKA 284
E D L+E A +N++R+ G + +++ + G+ + +K
Sbjct: 288 IEIFLVYIVPRAAIFHSDDALKESAA----MLNNMRVYGTAFLVLMVLVVFIGVRYVNKF 343
Query: 285 QVLFFLVIMVS----FANYLVGTLIPP 307
LF ++VS +A + + PP
Sbjct: 344 ASLFLACVIVSILAIYAGAIKSSFAPP 370
>gi|123701900 solute carrier family 12 (potassium/chloride
transporters), member 7 [Homo sapiens]
Length = 1083
Score = 234 bits (597), Expect = 3e-61
Identities = 192/746 (25%), Positives = 319/746 (42%), Gaps = 138/746 (18%)
Query: 338 TFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSCVV 397
+F + I+FPS TGI+AG+N SGDLKD +IP GT++AI T+ YL+ G+C+
Sbjct: 419 SFTLLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILAIVTTSFIYLSCIVLFGACI- 477
Query: 398 RDASGVLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAP-LI 456
VL D F E Q + + M++ +P +I
Sbjct: 478 --EGVVLRD------------------KFGEALQGNL----------VIGMLAWPSPWVI 507
Query: 457 TAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAV 516
G F +T + L L A ++ Q + D + P + FG G N EP LL I
Sbjct: 508 VIGSFFSTCGAGLQSLTGAPRLLQAIARDGIVPFLQVFGHGKA-NGEPTWALLLTVLICE 566
Query: 517 AFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIIS 576
I+IA L+++API+S FFL Y +N +C ++ +P WRP F++Y+ + G +
Sbjct: 567 TGILIASLDSVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKFYHWTLSFLGMSLC 626
Query: 577 VVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDH 636
+ +MF+ +W+ AL A+ + + Y+ Y+ E WG ++ S N A + + H
Sbjct: 627 LALMFICSWYYALSAMLIAGCIYKYIEYRGAEKEWGDGIRGLSLNAARYALLRVEHGPPH 686
Query: 637 IKNYRPQCLVLTG----PPNFRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPELQLIA 692
KN+RPQ LV+ P L+ F L I G VL G + + E Q
Sbjct: 687 TKNWRPQVLVMLNLDAEQAVKHPRLLSFTSQLKAGKGLTIVGSVLEGTYLDKHMEAQRAE 746
Query: 693 NGHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNW-QSAHPA 751
++ K K F V++ LR G+ L+Q+AGLG +K N +++ + +W Q +P
Sbjct: 747 ENIRSLMSTEKTKGFCQLVVSSSLRDGMSHLIQSAGLGGLKHNTVLMAWPASWKQEDNPF 806
Query: 752 TVEDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAHINPVFDPAEDGKEASARGARPSV 811
+ ++++ + D + + V + NV Q
Sbjct: 807 SWKNFVDTVRDTTAAHQALLVAK-----NVDSFPQN------------------------ 837
Query: 812 SGALDPKALVKEEQATTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRV 871
Q G ID++W+ DGG+ +L+P+LL + + W KC++R+
Sbjct: 838 -------------------QERFGGGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRI 878
Query: 872 FVGGQI-NRMDQERKAIISLLSKFRLGFHEVHILPDINQNPRA---EHTKRFE---DMIA 924
F Q+ + Q +K + L R+ EV ++ + + A E T E M+
Sbjct: 879 FTVAQVDDNSIQMKKDLQMFLYHLRIS-AEVEVVEMVENDISAFTYERTLMMEQRSQMLK 937
Query: 925 PFRLNDGFKDEA------------TVNEMRRDCPWKISDEEITKNRVKSLRQ-------- 964
+L+ ++ T R P ++T R K + +
Sbjct: 938 QMQLSKNEQEREAQLIHDRNTASHTAAAARTQAPPTPDKVQMTWTREKLIAEKYRSRDTS 997
Query: 965 -----------------------VRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAW 1001
V+LN +VL+ S+DA L+++ +P K + YM +
Sbjct: 998 LSGFKDLFSMKPDQSNVRRMHTAVKLNGVVLNKSQDAQLVLLNMPGPPKNRQGDENYMEF 1057
Query: 1002 LETLSQDLRPPVILIRGNQENVLTFY 1027
LE L++ L V+L+RG V+T Y
Sbjct: 1058 LEVLTEGLN-RVLLVRGGGREVITIY 1082
Score = 122 bits (307), Expect = 1e-27
Identities = 63/202 (31%), Positives = 112/202 (55%), Gaps = 9/202 (4%)
Query: 112 MTDGLVEGEAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTW 171
++ G+VE E S + + R G GV + C+ NI GVIL+LRL WI AG++ ++
Sbjct: 95 LSQGVVEHEEDEESRRREAKAPRMGTFIGVYLPCLQNILGVILFLRLTWIVGVAGVLESF 154
Query: 172 IIILLSVTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVA 231
+I+ + T T +T +S+SAI+TNG V +GG+Y++ISRSLGPE GG++GL F A
Sbjct: 155 LIVAMCCTCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGA 214
Query: 232 MHTVGFAETVRDLL---------QEYGAPIVDPINDIRIIGVVSVTVLLAISLAGMEWES 282
M+ +G E + + G ++++R+ G ++ ++ + G+++ +
Sbjct: 215 MYILGTIEIFLTYISPGAAIFQAEAAGGEAAAMLHNMRVYGTCTLVLMALVVFVGVKYVN 274
Query: 283 KAQVLFFLVIMVSFANYLVGTL 304
K ++F +++S G +
Sbjct: 275 KLALVFLACVVLSILAIYAGVI 296
>gi|225579061 solute carrier family 12, member 4 isoform b [Homo
sapiens]
Length = 1079
Score = 233 bits (594), Expect = 7e-61
Identities = 194/741 (26%), Positives = 313/741 (42%), Gaps = 132/741 (17%)
Query: 338 TFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSCVV 397
+F + IFFPS TGI+AG+N SGDL+D +IP GT++AI T++ Y + G+C+
Sbjct: 419 SFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACI- 477
Query: 398 RDASGVLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAPLIT 457
VL D G G L T++ S + +I
Sbjct: 478 --EGVVLRDKY--GDGVSRNLVVG-----------------------TLAWPSPW--VIV 508
Query: 458 AGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAVA 517
G F +T + L L A ++ Q + +D + P + FG G N EP LL IA
Sbjct: 509 IGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGK-VNGEPTWALLLTALIAEL 567
Query: 518 FIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIISV 577
I+IA L+ +API+S FFL Y +N +C ++ +P WRP F+YY+ + G + +
Sbjct: 568 GILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCL 627
Query: 578 VIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDHI 637
+MF+ +W+ AL+A+ + + Y+ Y+ E WG ++ S + A + L E H
Sbjct: 628 ALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHT 687
Query: 638 KNYRPQCLVLTGPPN----FRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPELQLIAN 693
KN+RPQ LVL P L+ F L I G V+ G + E Q
Sbjct: 688 KNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQ 747
Query: 694 GHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNW-QSAHPAT 752
+ K+K F V+A +R G+ L+Q+ GLG M+ N +V+G+ W QS P
Sbjct: 748 TIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRA 807
Query: 753 VEDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAHINPVFDPAEDGKEASARGARPSVS 812
+ +I + C L V K N F P+ +
Sbjct: 808 WKTFIDTVR---------CTTAAHLALLVPK------NIAFYPSNHERYLEGH------- 845
Query: 813 GALDPKALVKEEQATTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRVF 872
ID++W+ DGG+ +L+P+LL + + W KC++R+F
Sbjct: 846 --------------------------IDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIF 879
Query: 873 VGGQIN-----------------RMDQERKAIISLLSKFRLGFHEVHI----LPDINQNP 911
Q++ R++ E + IS + R E + +
Sbjct: 880 TVAQMDDNSIQMKKDLAVFLYHLRLEAEHNSDISAYTYERTLMMEQRSQMLRQMRLTKTE 939
Query: 912 RAEHTKRFEDMIAPFRLNDGF---KDEATVNEMRRDCPWKISDEEITK------------ 956
R + +D + RL + +DE+ V + W D+ +T+
Sbjct: 940 REREAQLVKDRHSALRLESLYSDEEDESAVGADKIQMTW-TRDKYMTETWDPSHAPDNFR 998
Query: 957 ----------NRVKSLRQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLETLS 1006
N + V+LNE+++ S DA L+++ +P + YM +LE L+
Sbjct: 999 ELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLT 1058
Query: 1007 QDLRPPVILIRGNQENVLTFY 1027
+ L V+L+RG V+T Y
Sbjct: 1059 EGLE-RVLLVRGGGREVITIY 1078
Score = 125 bits (315), Expect = 2e-28
Identities = 69/198 (34%), Positives = 111/198 (56%), Gaps = 17/198 (8%)
Query: 118 EGEAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLS 177
E E+G + + E G + GV + C+ NI+GVIL+LRL W+ AG++ +I+L+
Sbjct: 101 EAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLIC 160
Query: 178 VTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGF 237
T +T +S+SAI+TNG V +GG+YF+ISRSLGPE GG++GL F AM+ +G
Sbjct: 161 CCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGA 220
Query: 238 AETVRDLLQEYGAP---IVDP----------INDIRIIGVVSVTVLLAISLAGMEWESKA 284
E +L Y AP I P +N++R+ G + +T + + G+++ +K
Sbjct: 221 IE----ILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKF 276
Query: 285 QVLFFLVIMVSFANYLVG 302
LF +++S + G
Sbjct: 277 ASLFLACVIISILSIYAG 294
>gi|225579067 solute carrier family 12, member 4 isoform e [Homo
sapiens]
Length = 1054
Score = 231 bits (588), Expect = 3e-60
Identities = 195/748 (26%), Positives = 314/748 (41%), Gaps = 140/748 (18%)
Query: 338 TFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSCVV 397
+F + IFFPS TGI+AG+N SGDL+D +IP GT++AI T++ Y + G+C+
Sbjct: 388 SFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACI- 446
Query: 398 RDASGVLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAPLIT 457
VL D G G L T++ S + +I
Sbjct: 447 --EGVVLRDKY--GDGVSRNLVVG-----------------------TLAWPSPW--VIV 477
Query: 458 AGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAVA 517
G F +T + L L A ++ Q + +D + P + FG G N EP LL IA
Sbjct: 478 IGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGK-VNGEPTWALLLTALIAEL 536
Query: 518 FIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIISV 577
I+IA L+ +API+S FFL Y +N +C ++ +P WRP F+YY+ + G + +
Sbjct: 537 GILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCL 596
Query: 578 VIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDHI 637
+MF+ +W+ AL+A+ + + Y+ Y+ E WG ++ S + A + L E H
Sbjct: 597 ALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHT 656
Query: 638 KNYRPQCLVLTGPPN----FRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPELQLIAN 693
KN+RPQ LVL P L+ F L I G V+ G + E Q
Sbjct: 657 KNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQ 716
Query: 694 GHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNW-QSAHPAT 752
+ K+K F V+A +R G+ L+Q+ GLG M+ N +V+G+ W QS P
Sbjct: 717 TIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRA 776
Query: 753 VEDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAHINPVFDPAEDGKEASARGARPSVS 812
+ +I + C L V K N F P+ +
Sbjct: 777 WKTFIDTVR---------CTTAAHLALLVPK------NIAFYPSNHERYLEGH------- 814
Query: 813 GALDPKALVKEEQATTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRVF 872
ID++W+ DGG+ +L+P+LL + + W KC++R+F
Sbjct: 815 --------------------------IDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIF 848
Query: 873 VGGQI-NRMDQERKAIISLLSKFRLGFHEVHILP-------------------------- 905
Q+ + Q +K + L RL EV ++
Sbjct: 849 TVAQMDDNSIQMKKDLAVFLYHLRLE-AEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQ 907
Query: 906 -DINQNPRAEHTKRFEDMIAPFRLNDGF---KDEATVNEMRRDCPWKISDEEITK----- 956
+ + R + +D + RL + +DE+ V + W D+ +T+
Sbjct: 908 MRLTKTEREREAQLVKDRHSALRLESLYSDEEDESAVGADKIQMTW-TRDKYMTETWDPS 966
Query: 957 -----------------NRVKSLRQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYM 999
N + V+LNE+++ S DA L+++ +P + YM
Sbjct: 967 HAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYM 1026
Query: 1000 AWLETLSQDLRPPVILIRGNQENVLTFY 1027
+LE L++ L V+L+RG V+T Y
Sbjct: 1027 EFLEVLTEGLE-RVLLVRGGGREVITIY 1053
Score = 125 bits (315), Expect = 2e-28
Identities = 69/198 (34%), Positives = 111/198 (56%), Gaps = 17/198 (8%)
Query: 118 EGEAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLS 177
E E+G + + E G + GV + C+ NI+GVIL+LRL W+ AG++ +I+L+
Sbjct: 70 EAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLIC 129
Query: 178 VTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGF 237
T +T +S+SAI+TNG V +GG+YF+ISRSLGPE GG++GL F AM+ +G
Sbjct: 130 CCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGA 189
Query: 238 AETVRDLLQEYGAP---IVDP----------INDIRIIGVVSVTVLLAISLAGMEWESKA 284
E +L Y AP I P +N++R+ G + +T + + G+++ +K
Sbjct: 190 IE----ILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKF 245
Query: 285 QVLFFLVIMVSFANYLVG 302
LF +++S + G
Sbjct: 246 ASLFLACVIISILSIYAG 263
>gi|225579065 solute carrier family 12, member 4 isoform d [Homo
sapiens]
Length = 1079
Score = 231 bits (588), Expect = 3e-60
Identities = 195/748 (26%), Positives = 314/748 (41%), Gaps = 140/748 (18%)
Query: 338 TFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSCVV 397
+F + IFFPS TGI+AG+N SGDL+D +IP GT++AI T++ Y + G+C+
Sbjct: 413 SFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACI- 471
Query: 398 RDASGVLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAPLIT 457
VL D G G L T++ S + +I
Sbjct: 472 --EGVVLRDKY--GDGVSRNLVVG-----------------------TLAWPSPW--VIV 502
Query: 458 AGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAVA 517
G F +T + L L A ++ Q + +D + P + FG G N EP LL IA
Sbjct: 503 IGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGK-VNGEPTWALLLTALIAEL 561
Query: 518 FIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIISV 577
I+IA L+ +API+S FFL Y +N +C ++ +P WRP F+YY+ + G + +
Sbjct: 562 GILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCL 621
Query: 578 VIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDHI 637
+MF+ +W+ AL+A+ + + Y+ Y+ E WG ++ S + A + L E H
Sbjct: 622 ALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHT 681
Query: 638 KNYRPQCLVLTGPPN----FRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPELQLIAN 693
KN+RPQ LVL P L+ F L I G V+ G + E Q
Sbjct: 682 KNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQ 741
Query: 694 GHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNW-QSAHPAT 752
+ K+K F V+A +R G+ L+Q+ GLG M+ N +V+G+ W QS P
Sbjct: 742 TIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRA 801
Query: 753 VEDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAHINPVFDPAEDGKEASARGARPSVS 812
+ +I + C L V K N F P+ +
Sbjct: 802 WKTFIDTVR---------CTTAAHLALLVPK------NIAFYPSNHERYLEGH------- 839
Query: 813 GALDPKALVKEEQATTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRVF 872
ID++W+ DGG+ +L+P+LL + + W KC++R+F
Sbjct: 840 --------------------------IDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIF 873
Query: 873 VGGQI-NRMDQERKAIISLLSKFRLGFHEVHILP-------------------------- 905
Q+ + Q +K + L RL EV ++
Sbjct: 874 TVAQMDDNSIQMKKDLAVFLYHLRLE-AEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQ 932
Query: 906 -DINQNPRAEHTKRFEDMIAPFRLNDGF---KDEATVNEMRRDCPWKISDEEITK----- 956
+ + R + +D + RL + +DE+ V + W D+ +T+
Sbjct: 933 MRLTKTEREREAQLVKDRHSALRLESLYSDEEDESAVGADKIQMTW-TRDKYMTETWDPS 991
Query: 957 -----------------NRVKSLRQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYM 999
N + V+LNE+++ S DA L+++ +P + YM
Sbjct: 992 HAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYM 1051
Query: 1000 AWLETLSQDLRPPVILIRGNQENVLTFY 1027
+LE L++ L V+L+RG V+T Y
Sbjct: 1052 EFLEVLTEGLE-RVLLVRGGGREVITIY 1078
Score = 125 bits (315), Expect = 2e-28
Identities = 69/198 (34%), Positives = 111/198 (56%), Gaps = 17/198 (8%)
Query: 118 EGEAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLS 177
E E+G + + E G + GV + C+ NI+GVIL+LRL W+ AG++ +I+L+
Sbjct: 95 EAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLIC 154
Query: 178 VTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGF 237
T +T +S+SAI+TNG V +GG+YF+ISRSLGPE GG++GL F AM+ +G
Sbjct: 155 CCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGA 214
Query: 238 AETVRDLLQEYGAP---IVDP----------INDIRIIGVVSVTVLLAISLAGMEWESKA 284
E +L Y AP I P +N++R+ G + +T + + G+++ +K
Sbjct: 215 IE----ILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKF 270
Query: 285 QVLFFLVIMVSFANYLVG 302
LF +++S + G
Sbjct: 271 ASLFLACVIISILSIYAG 288
>gi|225579063 solute carrier family 12, member 4 isoform c [Homo
sapiens]
Length = 1087
Score = 231 bits (588), Expect = 3e-60
Identities = 195/748 (26%), Positives = 314/748 (41%), Gaps = 140/748 (18%)
Query: 338 TFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSCVV 397
+F + IFFPS TGI+AG+N SGDL+D +IP GT++AI T++ Y + G+C+
Sbjct: 421 SFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACI- 479
Query: 398 RDASGVLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAPLIT 457
VL D G G L T++ S + +I
Sbjct: 480 --EGVVLRDKY--GDGVSRNLVVG-----------------------TLAWPSPW--VIV 510
Query: 458 AGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAVA 517
G F +T + L L A ++ Q + +D + P + FG G N EP LL IA
Sbjct: 511 IGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGK-VNGEPTWALLLTALIAEL 569
Query: 518 FIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIISV 577
I+IA L+ +API+S FFL Y +N +C ++ +P WRP F+YY+ + G + +
Sbjct: 570 GILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCL 629
Query: 578 VIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDHI 637
+MF+ +W+ AL+A+ + + Y+ Y+ E WG ++ S + A + L E H
Sbjct: 630 ALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHT 689
Query: 638 KNYRPQCLVLTGPPN----FRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPELQLIAN 693
KN+RPQ LVL P L+ F L I G V+ G + E Q
Sbjct: 690 KNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQ 749
Query: 694 GHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNW-QSAHPAT 752
+ K+K F V+A +R G+ L+Q+ GLG M+ N +V+G+ W QS P
Sbjct: 750 TIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRA 809
Query: 753 VEDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAHINPVFDPAEDGKEASARGARPSVS 812
+ +I + C L V K N F P+ +
Sbjct: 810 WKTFIDTVR---------CTTAAHLALLVPK------NIAFYPSNHERYLEGH------- 847
Query: 813 GALDPKALVKEEQATTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRVF 872
ID++W+ DGG+ +L+P+LL + + W KC++R+F
Sbjct: 848 --------------------------IDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIF 881
Query: 873 VGGQI-NRMDQERKAIISLLSKFRLGFHEVHILP-------------------------- 905
Q+ + Q +K + L RL EV ++
Sbjct: 882 TVAQMDDNSIQMKKDLAVFLYHLRLE-AEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQ 940
Query: 906 -DINQNPRAEHTKRFEDMIAPFRLNDGF---KDEATVNEMRRDCPWKISDEEITK----- 956
+ + R + +D + RL + +DE+ V + W D+ +T+
Sbjct: 941 MRLTKTEREREAQLVKDRHSALRLESLYSDEEDESAVGADKIQMTW-TRDKYMTETWDPS 999
Query: 957 -----------------NRVKSLRQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYM 999
N + V+LNE+++ S DA L+++ +P + YM
Sbjct: 1000 HAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYM 1059
Query: 1000 AWLETLSQDLRPPVILIRGNQENVLTFY 1027
+LE L++ L V+L+RG V+T Y
Sbjct: 1060 EFLEVLTEGLE-RVLLVRGGGREVITIY 1086
Score = 125 bits (315), Expect = 2e-28
Identities = 69/198 (34%), Positives = 111/198 (56%), Gaps = 17/198 (8%)
Query: 118 EGEAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLS 177
E E+G + + E G + GV + C+ NI+GVIL+LRL W+ AG++ +I+L+
Sbjct: 103 EAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLIC 162
Query: 178 VTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGF 237
T +T +S+SAI+TNG V +GG+YF+ISRSLGPE GG++GL F AM+ +G
Sbjct: 163 CCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGA 222
Query: 238 AETVRDLLQEYGAP---IVDP----------INDIRIIGVVSVTVLLAISLAGMEWESKA 284
E +L Y AP I P +N++R+ G + +T + + G+++ +K
Sbjct: 223 IE----ILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKF 278
Query: 285 QVLFFLVIMVSFANYLVG 302
LF +++S + G
Sbjct: 279 ASLFLACVIISILSIYAG 296
>gi|4827006 solute carrier family 12, member 4 isoform a [Homo
sapiens]
Length = 1085
Score = 231 bits (588), Expect = 3e-60
Identities = 195/748 (26%), Positives = 314/748 (41%), Gaps = 140/748 (18%)
Query: 338 TFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSCVV 397
+F + IFFPS TGI+AG+N SGDL+D +IP GT++AI T++ Y + G+C+
Sbjct: 419 SFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACI- 477
Query: 398 RDASGVLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAPLIT 457
VL D G G L T++ S + +I
Sbjct: 478 --EGVVLRDKY--GDGVSRNLVVG-----------------------TLAWPSPW--VIV 508
Query: 458 AGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAVA 517
G F +T + L L A ++ Q + +D + P + FG G N EP LL IA
Sbjct: 509 IGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGK-VNGEPTWALLLTALIAEL 567
Query: 518 FIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIISV 577
I+IA L+ +API+S FFL Y +N +C ++ +P WRP F+YY+ + G + +
Sbjct: 568 GILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCL 627
Query: 578 VIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDHI 637
+MF+ +W+ AL+A+ + + Y+ Y+ E WG ++ S + A + L E H
Sbjct: 628 ALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHT 687
Query: 638 KNYRPQCLVLTGPPN----FRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPELQLIAN 693
KN+RPQ LVL P L+ F L I G V+ G + E Q
Sbjct: 688 KNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQ 747
Query: 694 GHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNW-QSAHPAT 752
+ K+K F V+A +R G+ L+Q+ GLG M+ N +V+G+ W QS P
Sbjct: 748 TIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRA 807
Query: 753 VEDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAHINPVFDPAEDGKEASARGARPSVS 812
+ +I + C L V K N F P+ +
Sbjct: 808 WKTFIDTVR---------CTTAAHLALLVPK------NIAFYPSNHERYLEGH------- 845
Query: 813 GALDPKALVKEEQATTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRVF 872
ID++W+ DGG+ +L+P+LL + + W KC++R+F
Sbjct: 846 --------------------------IDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIF 879
Query: 873 VGGQI-NRMDQERKAIISLLSKFRLGFHEVHILP-------------------------- 905
Q+ + Q +K + L RL EV ++
Sbjct: 880 TVAQMDDNSIQMKKDLAVFLYHLRLE-AEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQ 938
Query: 906 -DINQNPRAEHTKRFEDMIAPFRLNDGF---KDEATVNEMRRDCPWKISDEEITK----- 956
+ + R + +D + RL + +DE+ V + W D+ +T+
Sbjct: 939 MRLTKTEREREAQLVKDRHSALRLESLYSDEEDESAVGADKIQMTW-TRDKYMTETWDPS 997
Query: 957 -----------------NRVKSLRQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYM 999
N + V+LNE+++ S DA L+++ +P + YM
Sbjct: 998 HAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYM 1057
Query: 1000 AWLETLSQDLRPPVILIRGNQENVLTFY 1027
+LE L++ L V+L+RG V+T Y
Sbjct: 1058 EFLEVLTEGLE-RVLLVRGGGREVITIY 1084
Score = 125 bits (315), Expect = 2e-28
Identities = 69/198 (34%), Positives = 111/198 (56%), Gaps = 17/198 (8%)
Query: 118 EGEAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLS 177
E E+G + + E G + GV + C+ NI+GVIL+LRL W+ AG++ +I+L+
Sbjct: 101 EAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLIC 160
Query: 178 VTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGF 237
T +T +S+SAI+TNG V +GG+YF+ISRSLGPE GG++GL F AM+ +G
Sbjct: 161 CCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGA 220
Query: 238 AETVRDLLQEYGAP---IVDP----------INDIRIIGVVSVTVLLAISLAGMEWESKA 284
E +L Y AP I P +N++R+ G + +T + + G+++ +K
Sbjct: 221 IE----ILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKF 276
Query: 285 QVLFFLVIMVSFANYLVG 302
LF +++S + G
Sbjct: 277 ASLFLACVIISILSIYAG 294
>gi|38569457 solute carrier family 12, member 8 [Homo sapiens]
Length = 714
Score = 224 bits (572), Expect = 2e-58
Identities = 129/421 (30%), Positives = 217/421 (51%), Gaps = 48/421 (11%)
Query: 131 EPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLSVTVTSITGLSISA 190
EPV FG GV CM+NI+GV+L+LR W+ G++L ++ + V +T LS
Sbjct: 35 EPVLFGTWDGVFTSCMINIFGVVLFLRTGWLVGNTGVLLGMFLVSFVILVALVTVLSGIG 94
Query: 191 ISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAETVRDLLQEYGA 250
+ + SGG Y +IS LG + GG+IGL++ F V AM+ GFAE++ DLL
Sbjct: 95 VGERSSIGSGGVYSMISSVLGGQTGGTIGLLYVFGQCVAGAMYITGFAESISDLLG---- 150
Query: 251 PIVDPINDIRIIGVVSVTVLLAISLAGMEWESKAQVLFFLVIMVSFANYLVGTLIPPSED 310
+ I +R I V + LL I+LAG++W + Q+L ++ VS +++VG+ +
Sbjct: 151 --LGNIWAVRGISVAVLLALLGINLAGVKWIIRLQLLLLFLLAVSTLDFVVGSF---THL 205
Query: 311 KASKGFFSYRADIFVQNLVPDWRGPDGTFFGMFSIFFPSATGILAGANISGDLKDPAIAI 370
GF Y ++ N +PD+ P +FF +F +FFP+ATG++AG N+ GDL++PA +I
Sbjct: 206 DPEHGFIGYSPELLQNNTLPDY-SPGESFFTVFGVFFPAATGVMAGFNMGGDLREPAASI 264
Query: 371 PKGTLMAIFWTTISYLAISATIGSCVVRDASGVLNDTVTPGWGACEGLACSYGWNFTECT 430
P G+L A+ + Y+ +G+ R+ A Y + E
Sbjct: 265 PLGSLAAVGISWFLYIVFVFLLGAICTRE-------------------ALRYDFLIAE-- 303
Query: 431 QQHSCHYGLINYYQTMSMVSGFAPLITAGIFGATLSSALACLVSAAKVFQCLCEDQLYPL 490
VS L G++ ++L+S + L A ++ QC+ ++++ P
Sbjct: 304 -----------------KVSLMGFLFLLGLYISSLASCMGGLYGAPRILQCIAQEKVIPA 346
Query: 491 IGFFGKGYGKNKEPVRGYLLAYAIAVAFIIIAELNTIAPIISNFFLCSYALINFSCFHAS 550
+ G+G G NK PV L + +AF+ + ++N +API++ F+ +Y +++S F S
Sbjct: 347 LACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVAVDYSYFSLS 406
Query: 551 I 551
+
Sbjct: 407 M 407
Score = 44.7 bits (104), Expect = 5e-04
Identities = 21/62 (33%), Positives = 35/62 (56%), Gaps = 4/62 (6%)
Query: 557 WRPSFQYY----NKWAALFGAIISVVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWG 612
WR S +Y N W +L GA+ S++IMF++ W L+ +GV + Y+ P ++ G
Sbjct: 582 WRRSTSFYTHMCNPWVSLLGAVGSLLIMFVIQWVYTLVNMGVAAIVYFYIGRASPGLHLG 641
Query: 613 SS 614
S+
Sbjct: 642 SA 643
>gi|198041678 solute carrier family 12 (potassium-chloride
transporter), member 5 isoform 1 [Homo sapiens]
Length = 1139
Score = 222 bits (565), Expect = 2e-57
Identities = 160/566 (28%), Positives = 254/566 (44%), Gaps = 95/566 (16%)
Query: 342 MFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSC----VV 397
+ I+FPS TGI+AG+N SGDL+D +IP GT++AI T+ Y++ G+C V+
Sbjct: 426 LVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVL 485
Query: 398 RDASG-VLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAPLI 456
RD G +N + G LA W +I
Sbjct: 486 RDKFGEAVNGNLVVGT-----LAWPSPW------------------------------VI 510
Query: 457 TAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAV 516
G F +T + L L A ++ Q + D + P + FG G N EP LL I
Sbjct: 511 VIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKA-NGEPTWALLLTACICE 569
Query: 517 AFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIIS 576
I+IA L+ +API+S FFL Y +N +C ++ +P WRP F+YY+ + G +
Sbjct: 570 IGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLC 629
Query: 577 VVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDH 636
+ +MF+ +W+ AL+A+ + + Y+ Y+ E WG ++ S + A + L E H
Sbjct: 630 LALMFICSWYYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPH 689
Query: 637 IKNYRPQCLVLTGPPN----FRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPELQLIA 692
KN+RPQ LVL P L+ L I G VL G + P+ Q
Sbjct: 690 TKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQAQRAE 749
Query: 693 NGHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNW-QSAHPA 751
+ + K+K F VI+ +LR GV L+Q+ GLG ++ N ++VG+ +NW Q
Sbjct: 750 ESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQ 809
Query: 752 TVEDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAHINPVFDPAEDGKEASARGARPSV 811
T ++I ++ + + + V + NVS NP E + G
Sbjct: 810 TWRNFIELVRETTAGHLALLVTK-----NVSMFPG---NP---------ERFSEG----- 847
Query: 812 SGALDPKALVKEEQATTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRV 871
+ID++W+ DGG+ +L+P+LL + W KCK+R+
Sbjct: 848 --------------------------SIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRI 881
Query: 872 FVGGQI-NRMDQERKAIISLLSKFRL 896
F Q+ + Q +K + + L R+
Sbjct: 882 FTVAQMDDNSIQMKKDLTTFLYHLRI 907
Score = 120 bits (302), Expect = 5e-27
Identities = 65/204 (31%), Positives = 111/204 (54%), Gaps = 13/204 (6%)
Query: 118 EGEAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLS 177
E E +K P + R G GV + C+ NI+GVIL+LRL W+ AGI+ ++ ++ +
Sbjct: 103 EAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFIC 162
Query: 178 VTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGF 237
+ T +T +S+SAI+TNG V +GG+Y++ISRSLGPE GG++GL F AM+ +G
Sbjct: 163 CSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGT 222
Query: 238 AETVRDLL---------QEYGAPIVDPINDIRIIGVVSVTVLLAISLAGMEWESKAQVLF 288
E + L ++ +N++R+ G +T + + G+++ +K ++F
Sbjct: 223 IEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVF 282
Query: 289 ----FLVIMVSFANYLVGTLIPPS 308
L I+ +A + PP+
Sbjct: 283 LGCVILSILAIYAGVIKSAFDPPN 306
Score = 47.4 bits (111), Expect = 7e-05
Identities = 26/77 (33%), Positives = 46/77 (59%), Gaps = 2/77 (2%)
Query: 952 EEITKNRVKSLRQ-VRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLETLSQDLR 1010
E + ++ V+ + VRLNE+++ SRDA L+++ +P + + YM +LE L++ L
Sbjct: 1063 ENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEHL- 1121
Query: 1011 PPVILIRGNQENVLTFY 1027
V+L+RG V+T Y
Sbjct: 1122 DRVMLVRGGGREVITIY 1138
>gi|11968148 solute carrier family 12 (potassium-chloride
transporter), member 5 isoform 2 [Homo sapiens]
Length = 1116
Score = 222 bits (565), Expect = 2e-57
Identities = 160/566 (28%), Positives = 254/566 (44%), Gaps = 95/566 (16%)
Query: 342 MFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSC----VV 397
+ I+FPS TGI+AG+N SGDL+D +IP GT++AI T+ Y++ G+C V+
Sbjct: 403 LVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVL 462
Query: 398 RDASG-VLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAPLI 456
RD G +N + G LA W +I
Sbjct: 463 RDKFGEAVNGNLVVGT-----LAWPSPW------------------------------VI 487
Query: 457 TAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAV 516
G F +T + L L A ++ Q + D + P + FG G N EP LL I
Sbjct: 488 VIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKA-NGEPTWALLLTACICE 546
Query: 517 AFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIIS 576
I+IA L+ +API+S FFL Y +N +C ++ +P WRP F+YY+ + G +
Sbjct: 547 IGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLC 606
Query: 577 VVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDH 636
+ +MF+ +W+ AL+A+ + + Y+ Y+ E WG ++ S + A + L E H
Sbjct: 607 LALMFICSWYYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPH 666
Query: 637 IKNYRPQCLVLTGPPN----FRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPELQLIA 692
KN+RPQ LVL P L+ L I G VL G + P+ Q
Sbjct: 667 TKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQAQRAE 726
Query: 693 NGHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNW-QSAHPA 751
+ + K+K F VI+ +LR GV L+Q+ GLG ++ N ++VG+ +NW Q
Sbjct: 727 ESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQ 786
Query: 752 TVEDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAHINPVFDPAEDGKEASARGARPSV 811
T ++I ++ + + + V + NVS NP E + G
Sbjct: 787 TWRNFIELVRETTAGHLALLVTK-----NVSMFPG---NP---------ERFSEG----- 824
Query: 812 SGALDPKALVKEEQATTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRV 871
+ID++W+ DGG+ +L+P+LL + W KCK+R+
Sbjct: 825 --------------------------SIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRI 858
Query: 872 FVGGQI-NRMDQERKAIISLLSKFRL 896
F Q+ + Q +K + + L R+
Sbjct: 859 FTVAQMDDNSIQMKKDLTTFLYHLRI 884
Score = 120 bits (302), Expect = 5e-27
Identities = 65/204 (31%), Positives = 111/204 (54%), Gaps = 13/204 (6%)
Query: 118 EGEAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLS 177
E E +K P + R G GV + C+ NI+GVIL+LRL W+ AGI+ ++ ++ +
Sbjct: 80 EAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFIC 139
Query: 178 VTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGF 237
+ T +T +S+SAI+TNG V +GG+Y++ISRSLGPE GG++GL F AM+ +G
Sbjct: 140 CSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGT 199
Query: 238 AETVRDLL---------QEYGAPIVDPINDIRIIGVVSVTVLLAISLAGMEWESKAQVLF 288
E + L ++ +N++R+ G +T + + G+++ +K ++F
Sbjct: 200 IEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVF 259
Query: 289 ----FLVIMVSFANYLVGTLIPPS 308
L I+ +A + PP+
Sbjct: 260 LGCVILSILAIYAGVIKSAFDPPN 283
Score = 47.4 bits (111), Expect = 7e-05
Identities = 26/77 (33%), Positives = 46/77 (59%), Gaps = 2/77 (2%)
Query: 952 EEITKNRVKSLRQ-VRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLETLSQDLR 1010
E + ++ V+ + VRLNE+++ SRDA L+++ +P + + YM +LE L++ L
Sbjct: 1040 ENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEHL- 1098
Query: 1011 PPVILIRGNQENVLTFY 1027
V+L+RG V+T Y
Sbjct: 1099 DRVMLVRGGGREVITIY 1115
>gi|55743077 ATPase, class I, type 8B, member 2 isoform b [Homo
sapiens]
Length = 387
Score = 35.8 bits (81), Expect = 0.21
Identities = 30/116 (25%), Positives = 55/116 (47%), Gaps = 9/116 (7%)
Query: 524 LNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIISVVIMFLL 583
+NT+ I F +C ++ +A + G R FQ Y W A+ S L
Sbjct: 273 MNTLVLWIFGFLVCMGVILAIG--NAIWEHEVGMR--FQVYLPWDE---AVDSAFFSGFL 325
Query: 584 TWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDHIKN 639
++W+ +I + V+ + LYV Y P + WG S ++G + L +S+ + + + K+
Sbjct: 326 SFWSYIIILNTVVPISLYVRY-VPSLTWGLSRESGG-PIELFFSMKMKSLRSNEKS 379
>gi|134304858 solute carrier family 7, member 2 isoform 2 [Homo
sapiens]
Length = 658
Score = 34.7 bits (78), Expect = 0.48
Identities = 62/287 (21%), Positives = 106/287 (36%), Gaps = 57/287 (19%)
Query: 260 RIIGVVSVTVLLAISLAGMEWESKAQVLFFLVIMVSFANYLVGTLIPPSEDKAS----KG 315
++ V++ VLL + +AG K V + + N PPSE+ S G
Sbjct: 192 KVFTAVNILVLLFVMVAGFV---KGNVANWKISEEFLKNISASAREPPSENGTSIYGAGG 248
Query: 316 FFSYRADIFVQNLVPDWRGPDGTFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTL 375
F Y G GT G + F+ + G A ++++P AIP G +
Sbjct: 249 FMPY--------------GFTGTLAGAATCFY-AFVGFDCIATTGEEVRNPQKAIPIGIV 293
Query: 376 MAIFWTTISYLAISATIGSCVVRDASGVLNDTVTPGWGACEGLACSYGWNFTECTQQHSC 435
++ ++Y +SA + + L D +P A E + GW
Sbjct: 294 TSLLVCFMAYFGVSAALTLMM----PYYLLDEKSPLPVAFEYV----GW----------- 334
Query: 436 HYGLINYYQTMSMVSGFAPLITAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFG 495
G Y ++ AG A +S L + +V + ED L L
Sbjct: 335 --GPAKY------------VVAAGSLCALSTSLLGSIFPMPRVIYAMAEDGL--LFKCLA 378
Query: 496 KGYGKNKEPVRGYLLAYAIAVAFIIIAELNTIAPIISNFFLCSYALI 542
+ K K P+ L + A+A + +L + ++S L +Y+L+
Sbjct: 379 QINSKTKTPIIATLSSGAVAALMAFLFDLKALVDMMSIGTLMAYSLV 425
>gi|7657683 solute carrier family 7, (cationic amino acid
transporter, y+ system) member 11 [Homo sapiens]
Length = 501
Score = 32.7 bits (73), Expect = 1.8
Identities = 44/219 (20%), Positives = 89/219 (40%), Gaps = 22/219 (10%)
Query: 176 LSVTVTSITG-------LSISAISTNGKVKSGGTYFLISRSLGP-ELGGSIGLIFAFANA 227
+S+T+ ++ G LS + + T K KSGG Y I GP + +
Sbjct: 78 MSLTIWTVCGVLSLFGALSYAELGTTIK-KSGGHYTYILEVFGPLPAFVRVWVELLIIRP 136
Query: 228 VGVAMHTVGFAETVRDLLQEYGAPIVDPINDIRIIGVVSVTVLLAISLAGMEWESKAQVL 287
A+ ++ F R +L+ + P I++I V +TV++ ++ + W ++ Q+
Sbjct: 137 AATAVISLAFG---RYILEPFFIQCEIPELAIKLITAVGITVVMVLNSMSVSWSARIQIF 193
Query: 288 FFLVIMVSFANYLVGTLIPPSEDKASKGFFSYRADIFVQNLVPDWRGPDGTFFGMFSIFF 347
+ + + +I P + KG D F R P ++GM++
Sbjct: 194 LTFCKLTA-----ILIIIVPGVMQLIKGQTQNFKDAFSGRDSSITRLPLAFYYGMYAY-- 246
Query: 348 PSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYL 386
G ++ ++++P IP +++ TI Y+
Sbjct: 247 ---AGWFYLNFVTEEVENPEKTIPLAICISMAIVTIGYV 282
>gi|239740773 PREDICTED: similar to diffuse panbronchiolitis critical
region 1 [Homo sapiens]
Length = 1400
Score = 32.3 bits (72), Expect = 2.4
Identities = 20/66 (30%), Positives = 35/66 (53%), Gaps = 1/66 (1%)
Query: 2 AELPTTETPGDATLC-SGRFTISTLLSSDEPSPPAAYDSSHPSHLTHSSTFCMRTFGYNT 60
+E+PT T AT S + + +T+ S+ +PP +++ S T +ST G++T
Sbjct: 1189 SEIPTASTTDSATTAISTKASGTTVESAPSTAPPTPAETTTASVPTTTSTTGSENTGHHT 1248
Query: 61 IDVVPT 66
+ VPT
Sbjct: 1249 VSSVPT 1254
>gi|6005715 solute carrier family 6 (amino acid transporter), member
14 [Homo sapiens]
Length = 642
Score = 32.0 bits (71), Expect = 3.1
Identities = 21/62 (33%), Positives = 29/62 (46%), Gaps = 10/62 (16%)
Query: 543 NFSCFHASITNSPGWRPSFQYYNKWAAL-------FGAIISVVIMFLLTWWAALIAIGVV 595
NF+C + S PG PS QY+NK A G I+ + + LL W + +G
Sbjct: 197 NFTCINGSEIYQPGQLPSEQYWNKVALQRSSGMNETGVIVWYLALCLLLAW---LIVGAA 253
Query: 596 LF 597
LF
Sbjct: 254 LF 255
>gi|109948288 solute carrier family 7, member 2 isoform 1 [Homo
sapiens]
Length = 697
Score = 31.6 bits (70), Expect = 4.0
Identities = 61/287 (21%), Positives = 105/287 (36%), Gaps = 58/287 (20%)
Query: 260 RIIGVVSVTVLLAISLAGMEWESKAQVLFFLVIMVSFANYLVGTLIPPSEDKAS----KG 315
++ V++ VLL + +AG K V + + N PPSE+ S G
Sbjct: 232 KVFTAVNILVLLFVMVAGFV---KGNVANWKISEEFLKNISASAREPPSENGTSIYGAGG 288
Query: 316 FFSYRADIFVQNLVPDWRGPDGTFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTL 375
F Y G GT G + F+ + G A ++++P AIP G +
Sbjct: 289 FMPY--------------GFTGTLAGAATCFY-AFVGFDCIATTGEEVRNPQKAIPIGIV 333
Query: 376 MAIFWTTISYLAISATIGSCVVRDASGVLNDTVTPGWGACEGLACSYGWNFTECTQQHSC 435
++ ++Y +SA + + L D +P A E + GW
Sbjct: 334 TSLLVCFMAYFGVSAALTLMM----PYYLLDEKSPLPVAFEYV----GW----------- 374
Query: 436 HYGLINYYQTMSMVSGFAPLITAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFG 495
G Y ++ AG A +S L + ++ + D L L F
Sbjct: 375 --GPAKY------------VVAAGSLCALSTSLLGSMFPLPRILFAMARDGL--LFRFLA 418
Query: 496 KGYGKNKEPVRGYLLAYAIAVAFIIIAELNTIAPIISNFFLCSYALI 542
+ K + PV L A I+ + +L + ++S L +Y+L+
Sbjct: 419 R-VSKRQSPVAATLTAGVISALMAFLFDLKALVDMMSIGTLMAYSLV 464
>gi|153792564 solute carrier family 47, member 2 isoform 2 [Homo
sapiens]
Length = 566
Score = 30.8 bits (68), Expect = 6.9
Identities = 24/92 (26%), Positives = 35/92 (38%), Gaps = 4/92 (4%)
Query: 512 YAIAVAFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALF 571
YA+ + + A IIS F + L+ + GW S Q W F
Sbjct: 199 YALVSVLNLGVRGSAYANIISQFAQTVFLLLYIVLKKLHLETWAGW--SSQCLQDWGPFF 256
Query: 572 GAIISVVIMFLLTWWAALIAIGVVLFLLLYVI 603
+ ++M + WWA IG L LL V+
Sbjct: 257 SLAVPSMLMICVEWWA--YEIGSFLMGLLSVV 286
>gi|38261960 solute carrier family 47, member 2 isoform 1 [Homo
sapiens]
Length = 602
Score = 30.8 bits (68), Expect = 6.9
Identities = 24/92 (26%), Positives = 35/92 (38%), Gaps = 4/92 (4%)
Query: 512 YAIAVAFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALF 571
YA+ + + A IIS F + L+ + GW S Q W F
Sbjct: 235 YALVSVLNLGVRGSAYANIISQFAQTVFLLLYIVLKKLHLETWAGW--SSQCLQDWGPFF 292
Query: 572 GAIISVVIMFLLTWWAALIAIGVVLFLLLYVI 603
+ ++M + WWA IG L LL V+
Sbjct: 293 SLAVPSMLMICVEWWA--YEIGSFLMGLLSVV 322
>gi|203098995 solute carrier family 2 (facilitated glucose
transporter), member 13 [Homo sapiens]
Length = 648
Score = 30.4 bits (67), Expect = 9.0
Identities = 22/88 (25%), Positives = 35/88 (39%), Gaps = 7/88 (7%)
Query: 380 WTTISYLAISATIGSCVVRDASGVLNDTVTPGWGACEGLACSYGWNF-----TECTQQHS 434
WT + L + + + +N + P W G ACS G N+ T H+
Sbjct: 507 WTALLGLILYLVFFAPGMGPMPWTVNSEIYPLWARSTGNACSSGINWIFNVLVSLTFLHT 566
Query: 435 CHYGLINYYQTMSMVSGFAPLITAGIFG 462
Y + YY + +GFA + I+G
Sbjct: 567 AEY--LTYYGAFFLYAGFAAVGLLFIYG 592
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.139 0.428
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,618,757
Number of Sequences: 37866
Number of extensions: 1671332
Number of successful extensions: 3703
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 21
Number of HSP's successfully gapped in prelim test: 10
Number of HSP's that attempted gapping in prelim test: 3568
Number of HSP's gapped (non-prelim): 114
length of query: 1029
length of database: 18,247,518
effective HSP length: 112
effective length of query: 917
effective length of database: 14,006,526
effective search space: 12843984342
effective search space used: 12843984342
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.