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Search of human proteins with 186910315
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|186910315 solute carrier family 12, member 3 isoform 1 [Homo
sapiens]
(1030 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|186910315 solute carrier family 12, member 3 isoform 1 [Homo ... 2083 0.0
gi|186910317 solute carrier family 12, member 3 isoform 2 [Homo ... 2076 0.0
gi|186910319 solute carrier family 12, member 3 isoform 3 [Homo ... 2057 0.0
gi|4506975 solute carrier family 12 (sodium/potassium/chloride t... 1074 0.0
gi|134254459 sodium potassium chloride cotransporter 2 [Homo sap... 1061 0.0
gi|31881740 solute carrier family 12 (potassium/chloride transpo... 248 2e-65
gi|110224458 solute carrier family 12, member 6 isoform e [Homo ... 236 1e-61
gi|110224456 solute carrier family 12, member 6 isoform d [Homo ... 236 1e-61
gi|110224454 solute carrier family 12, member 6 isoform c [Homo ... 236 1e-61
gi|110224452 solute carrier family 12, member 6 isoform c [Homo ... 236 1e-61
gi|4826780 solute carrier family 12, member 6 isoform b [Homo sa... 236 1e-61
gi|110224449 solute carrier family 12, member 6 isoform a [Homo ... 236 1e-61
gi|123701900 solute carrier family 12 (potassium/chloride transp... 234 3e-61
gi|225579061 solute carrier family 12, member 4 isoform b [Homo ... 233 7e-61
gi|225579067 solute carrier family 12, member 4 isoform e [Homo ... 231 3e-60
gi|225579065 solute carrier family 12, member 4 isoform d [Homo ... 231 3e-60
gi|225579063 solute carrier family 12, member 4 isoform c [Homo ... 231 3e-60
gi|4827006 solute carrier family 12, member 4 isoform a [Homo sa... 231 3e-60
gi|38569457 solute carrier family 12, member 8 [Homo sapiens] 224 2e-58
gi|198041678 solute carrier family 12 (potassium-chloride transp... 222 2e-57
gi|11968148 solute carrier family 12 (potassium-chloride transpo... 222 2e-57
gi|55743077 ATPase, class I, type 8B, member 2 isoform b [Homo s... 36 0.21
gi|134304858 solute carrier family 7, member 2 isoform 2 [Homo s... 35 0.48
gi|7657683 solute carrier family 7, (cationic amino acid transpo... 33 1.8
gi|239740773 PREDICTED: similar to diffuse panbronchiolitis crit... 32 2.4
gi|6005715 solute carrier family 6 (amino acid transporter), mem... 32 3.1
gi|109948288 solute carrier family 7, member 2 isoform 1 [Homo s... 32 4.0
gi|153792564 solute carrier family 47, member 2 isoform 2 [Homo ... 31 6.9
gi|38261960 solute carrier family 47, member 2 isoform 1 [Homo s... 31 6.9
gi|203098995 solute carrier family 2 (facilitated glucose transp... 30 9.0
>gi|186910315 solute carrier family 12, member 3 isoform 1 [Homo
sapiens]
Length = 1030
Score = 2083 bits (5396), Expect = 0.0
Identities = 1030/1030 (100%), Positives = 1030/1030 (100%)
Query: 1 MAELPTTETPGDATLCSGRFTISTLLSSDEPSPPAAYDSSHPSHLTHSSTFCMRTFGYNT 60
MAELPTTETPGDATLCSGRFTISTLLSSDEPSPPAAYDSSHPSHLTHSSTFCMRTFGYNT
Sbjct: 1 MAELPTTETPGDATLCSGRFTISTLLSSDEPSPPAAYDSSHPSHLTHSSTFCMRTFGYNT 60
Query: 61 IDVVPTYEHYANSTQPGEPRKVRPTLADLHSFLKQEGRHLHALAFDSRPSHEMTDGLVEG 120
IDVVPTYEHYANSTQPGEPRKVRPTLADLHSFLKQEGRHLHALAFDSRPSHEMTDGLVEG
Sbjct: 61 IDVVPTYEHYANSTQPGEPRKVRPTLADLHSFLKQEGRHLHALAFDSRPSHEMTDGLVEG 120
Query: 121 EAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLSVT 180
EAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLSVT
Sbjct: 121 EAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLSVT 180
Query: 181 VTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAE 240
VTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAE
Sbjct: 181 VTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAE 240
Query: 241 TVRDLLQEYGAPIVDPINDIRIIGVVSVTVLLAISLAGMEWESKAQVLFFLVIMVSFANY 300
TVRDLLQEYGAPIVDPINDIRIIGVVSVTVLLAISLAGMEWESKAQVLFFLVIMVSFANY
Sbjct: 241 TVRDLLQEYGAPIVDPINDIRIIGVVSVTVLLAISLAGMEWESKAQVLFFLVIMVSFANY 300
Query: 301 LVGTLIPPSEDKASKGFFSYRADIFVQNLVPDWRGPDGTFFGMFSIFFPSATGILAGANI 360
LVGTLIPPSEDKASKGFFSYRADIFVQNLVPDWRGPDGTFFGMFSIFFPSATGILAGANI
Sbjct: 301 LVGTLIPPSEDKASKGFFSYRADIFVQNLVPDWRGPDGTFFGMFSIFFPSATGILAGANI 360
Query: 361 SGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSCVVRDASGVLNDTVTPGWGACEGLA 420
SGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSCVVRDASGVLNDTVTPGWGACEGLA
Sbjct: 361 SGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSCVVRDASGVLNDTVTPGWGACEGLA 420
Query: 421 CSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAPLITAGIFGATLSSALACLVSAAKVF 480
CSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAPLITAGIFGATLSSALACLVSAAKVF
Sbjct: 421 CSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAPLITAGIFGATLSSALACLVSAAKVF 480
Query: 481 QCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAVAFIIIAELNTIAPIISNFFLCSY 540
QCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAVAFIIIAELNTIAPIISNFFLCSY
Sbjct: 481 QCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAVAFIIIAELNTIAPIISNFFLCSY 540
Query: 541 ALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIISVVIMFLLTWWAALIAIGVVLFLL 600
ALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIISVVIMFLLTWWAALIAIGVVLFLL
Sbjct: 541 ALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIISVVIMFLLTWWAALIAIGVVLFLL 600
Query: 601 LYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDHIKNYRPQCLVLTGPPNFRPALVD 660
LYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDHIKNYRPQCLVLTGPPNFRPALVD
Sbjct: 601 LYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDHIKNYRPQCLVLTGPPNFRPALVD 660
Query: 661 FVGTFTRNLSLMICGHVLIGPHKQRMPELQLIANGHTKWLNKRKIKAFYSDVIAEDLRRG 720
FVGTFTRNLSLMICGHVLIGPHKQRMPELQLIANGHTKWLNKRKIKAFYSDVIAEDLRRG
Sbjct: 661 FVGTFTRNLSLMICGHVLIGPHKQRMPELQLIANGHTKWLNKRKIKAFYSDVIAEDLRRG 720
Query: 721 VQILMQAAGLGRMKPNILVVGFKKNWQSAHPATVEDYIGILHDAFDFNYGVCVMRMREGL 780
VQILMQAAGLGRMKPNILVVGFKKNWQSAHPATVEDYIGILHDAFDFNYGVCVMRMREGL
Sbjct: 721 VQILMQAAGLGRMKPNILVVGFKKNWQSAHPATVEDYIGILHDAFDFNYGVCVMRMREGL 780
Query: 781 NVSKMMQAHINPVFDPAEDGKEASARGARPSVSGALDPKALVKEEQATTIFQSEQGKKTI 840
NVSKMMQAHINPVFDPAEDGKEASARGARPSVSGALDPKALVKEEQATTIFQSEQGKKTI
Sbjct: 781 NVSKMMQAHINPVFDPAEDGKEASARGARPSVSGALDPKALVKEEQATTIFQSEQGKKTI 840
Query: 841 DIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRVFVGGQINRMDQERKAIISLLSKFRLGFH 900
DIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRVFVGGQINRMDQERKAIISLLSKFRLGFH
Sbjct: 841 DIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRVFVGGQINRMDQERKAIISLLSKFRLGFH 900
Query: 901 EVHILPDINQNPRAEHTKRFEDMIAPFRLNDGFKDEATVNEMRRDCPWKISDEEITKNRV 960
EVHILPDINQNPRAEHTKRFEDMIAPFRLNDGFKDEATVNEMRRDCPWKISDEEITKNRV
Sbjct: 901 EVHILPDINQNPRAEHTKRFEDMIAPFRLNDGFKDEATVNEMRRDCPWKISDEEITKNRV 960
Query: 961 KSLRQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLETLSQDLRPPVILIRGN 1020
KSLRQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLETLSQDLRPPVILIRGN
Sbjct: 961 KSLRQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLETLSQDLRPPVILIRGN 1020
Query: 1021 QENVLTFYCQ 1030
QENVLTFYCQ
Sbjct: 1021 QENVLTFYCQ 1030
>gi|186910317 solute carrier family 12, member 3 isoform 2 [Homo
sapiens]
Length = 1029
Score = 2076 bits (5379), Expect = 0.0
Identities = 1029/1030 (99%), Positives = 1029/1030 (99%), Gaps = 1/1030 (0%)
Query: 1 MAELPTTETPGDATLCSGRFTISTLLSSDEPSPPAAYDSSHPSHLTHSSTFCMRTFGYNT 60
MAELPTTETPGDATLCSGRFTISTLLSSDEPSPPAAYDSSHPSHLTHSSTFCMRTFGYNT
Sbjct: 1 MAELPTTETPGDATLCSGRFTISTLLSSDEPSPPAAYDSSHPSHLTHSSTFCMRTFGYNT 60
Query: 61 IDVVPTYEHYANSTQPGEPRKVRPTLADLHSFLKQEGRHLHALAFDSRPSHEMTDGLVEG 120
IDVVPTYEHYANSTQPGEPRKVRPTLADLHSFLK EGRHLHALAFDSRPSHEMTDGLVEG
Sbjct: 61 IDVVPTYEHYANSTQPGEPRKVRPTLADLHSFLK-EGRHLHALAFDSRPSHEMTDGLVEG 119
Query: 121 EAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLSVT 180
EAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLSVT
Sbjct: 120 EAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLSVT 179
Query: 181 VTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAE 240
VTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAE
Sbjct: 180 VTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAE 239
Query: 241 TVRDLLQEYGAPIVDPINDIRIIGVVSVTVLLAISLAGMEWESKAQVLFFLVIMVSFANY 300
TVRDLLQEYGAPIVDPINDIRIIGVVSVTVLLAISLAGMEWESKAQVLFFLVIMVSFANY
Sbjct: 240 TVRDLLQEYGAPIVDPINDIRIIGVVSVTVLLAISLAGMEWESKAQVLFFLVIMVSFANY 299
Query: 301 LVGTLIPPSEDKASKGFFSYRADIFVQNLVPDWRGPDGTFFGMFSIFFPSATGILAGANI 360
LVGTLIPPSEDKASKGFFSYRADIFVQNLVPDWRGPDGTFFGMFSIFFPSATGILAGANI
Sbjct: 300 LVGTLIPPSEDKASKGFFSYRADIFVQNLVPDWRGPDGTFFGMFSIFFPSATGILAGANI 359
Query: 361 SGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSCVVRDASGVLNDTVTPGWGACEGLA 420
SGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSCVVRDASGVLNDTVTPGWGACEGLA
Sbjct: 360 SGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSCVVRDASGVLNDTVTPGWGACEGLA 419
Query: 421 CSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAPLITAGIFGATLSSALACLVSAAKVF 480
CSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAPLITAGIFGATLSSALACLVSAAKVF
Sbjct: 420 CSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAPLITAGIFGATLSSALACLVSAAKVF 479
Query: 481 QCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAVAFIIIAELNTIAPIISNFFLCSY 540
QCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAVAFIIIAELNTIAPIISNFFLCSY
Sbjct: 480 QCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAVAFIIIAELNTIAPIISNFFLCSY 539
Query: 541 ALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIISVVIMFLLTWWAALIAIGVVLFLL 600
ALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIISVVIMFLLTWWAALIAIGVVLFLL
Sbjct: 540 ALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIISVVIMFLLTWWAALIAIGVVLFLL 599
Query: 601 LYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDHIKNYRPQCLVLTGPPNFRPALVD 660
LYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDHIKNYRPQCLVLTGPPNFRPALVD
Sbjct: 600 LYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDHIKNYRPQCLVLTGPPNFRPALVD 659
Query: 661 FVGTFTRNLSLMICGHVLIGPHKQRMPELQLIANGHTKWLNKRKIKAFYSDVIAEDLRRG 720
FVGTFTRNLSLMICGHVLIGPHKQRMPELQLIANGHTKWLNKRKIKAFYSDVIAEDLRRG
Sbjct: 660 FVGTFTRNLSLMICGHVLIGPHKQRMPELQLIANGHTKWLNKRKIKAFYSDVIAEDLRRG 719
Query: 721 VQILMQAAGLGRMKPNILVVGFKKNWQSAHPATVEDYIGILHDAFDFNYGVCVMRMREGL 780
VQILMQAAGLGRMKPNILVVGFKKNWQSAHPATVEDYIGILHDAFDFNYGVCVMRMREGL
Sbjct: 720 VQILMQAAGLGRMKPNILVVGFKKNWQSAHPATVEDYIGILHDAFDFNYGVCVMRMREGL 779
Query: 781 NVSKMMQAHINPVFDPAEDGKEASARGARPSVSGALDPKALVKEEQATTIFQSEQGKKTI 840
NVSKMMQAHINPVFDPAEDGKEASARGARPSVSGALDPKALVKEEQATTIFQSEQGKKTI
Sbjct: 780 NVSKMMQAHINPVFDPAEDGKEASARGARPSVSGALDPKALVKEEQATTIFQSEQGKKTI 839
Query: 841 DIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRVFVGGQINRMDQERKAIISLLSKFRLGFH 900
DIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRVFVGGQINRMDQERKAIISLLSKFRLGFH
Sbjct: 840 DIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRVFVGGQINRMDQERKAIISLLSKFRLGFH 899
Query: 901 EVHILPDINQNPRAEHTKRFEDMIAPFRLNDGFKDEATVNEMRRDCPWKISDEEITKNRV 960
EVHILPDINQNPRAEHTKRFEDMIAPFRLNDGFKDEATVNEMRRDCPWKISDEEITKNRV
Sbjct: 900 EVHILPDINQNPRAEHTKRFEDMIAPFRLNDGFKDEATVNEMRRDCPWKISDEEITKNRV 959
Query: 961 KSLRQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLETLSQDLRPPVILIRGN 1020
KSLRQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLETLSQDLRPPVILIRGN
Sbjct: 960 KSLRQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLETLSQDLRPPVILIRGN 1019
Query: 1021 QENVLTFYCQ 1030
QENVLTFYCQ
Sbjct: 1020 QENVLTFYCQ 1029
>gi|186910319 solute carrier family 12, member 3 isoform 3 [Homo
sapiens]
Length = 1021
Score = 2057 bits (5329), Expect = 0.0
Identities = 1020/1030 (99%), Positives = 1021/1030 (99%), Gaps = 9/1030 (0%)
Query: 1 MAELPTTETPGDATLCSGRFTISTLLSSDEPSPPAAYDSSHPSHLTHSSTFCMRTFGYNT 60
MAELPTTETPGDATLCSGRFTISTLLSSDEPSPPAAYDSSHPSHLTHSSTFCMRTFGYNT
Sbjct: 1 MAELPTTETPGDATLCSGRFTISTLLSSDEPSPPAAYDSSHPSHLTHSSTFCMRTFGYNT 60
Query: 61 IDVVPTYEHYANSTQPGEPRKVRPTLADLHSFLKQEGRHLHALAFDSRPSHEMTDGLVEG 120
IDVVPTYEHYANSTQPGEPRKVRPTLADLHSFLKQEGRHLHALAFDSRPSHEMTDGLVEG
Sbjct: 61 IDVVPTYEHYANSTQPGEPRKVRPTLADLHSFLKQEGRHLHALAFDSRPSHEMTDGLVEG 120
Query: 121 EAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLSVT 180
EAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLSVT
Sbjct: 121 EAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLSVT 180
Query: 181 VTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAE 240
VTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAE
Sbjct: 181 VTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAE 240
Query: 241 TVRDLLQEYGAPIVDPINDIRIIGVVSVTVLLAISLAGMEWESKAQVLFFLVIMVSFANY 300
TVRDLLQEYGAPIVDPINDIRIIGVVSVTVLLAISLAGMEWESKAQVLFFLVIMVSFANY
Sbjct: 241 TVRDLLQEYGAPIVDPINDIRIIGVVSVTVLLAISLAGMEWESKAQVLFFLVIMVSFANY 300
Query: 301 LVGTLIPPSEDKASKGFFSYRADIFVQNLVPDWRGPDGTFFGMFSIFFPSATGILAGANI 360
LVGTLIPPSEDKASKGFFSYRADIFVQNLVPDWRGPDGTFFGMFSIFFPSATGILAGANI
Sbjct: 301 LVGTLIPPSEDKASKGFFSYRADIFVQNLVPDWRGPDGTFFGMFSIFFPSATGILAGANI 360
Query: 361 SGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSCVVRDASGVLNDTVTPGWGACEGLA 420
SGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSCVVRDASGVLNDTVTPGWGACEGLA
Sbjct: 361 SGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSCVVRDASGVLNDTVTPGWGACEGLA 420
Query: 421 CSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAPLITAGIFGATLSSALACLVSAAKVF 480
CSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAPLITAGIFGATLSSALACLVSAAKVF
Sbjct: 421 CSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAPLITAGIFGATLSSALACLVSAAKVF 480
Query: 481 QCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAVAFIIIAELNTIAPIISNFFLCSY 540
QCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAVAFIIIAELNTIAPIISNFFLCSY
Sbjct: 481 QCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAVAFIIIAELNTIAPIISNFFLCSY 540
Query: 541 ALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIISVVIMFLLTWWAALIAIGVVLFLL 600
ALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIISVVIMFLLTWWAALIAIGVVLFLL
Sbjct: 541 ALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIISVVIMFLLTWWAALIAIGVVLFLL 600
Query: 601 LYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDHIKNYRPQCLVLTGPPNFRPALVD 660
LYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDHIKNYRPQCLVLTGPPNFRPALVD
Sbjct: 601 LYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDHIKNYRPQCLVLTGPPNFRPALVD 660
Query: 661 FVGTFTRNLSLMICGHVLIGPHKQRMPELQLIANGHTKWLNKRKIKAFYSDVIAEDLRRG 720
FVGTFTRNLSLMICGHVLIGPHKQRMPELQLIANGHTKWLNKRKIKAFYSDVIAEDLRRG
Sbjct: 661 FVGTFTRNLSLMICGHVLIGPHKQRMPELQLIANGHTKWLNKRKIKAFYSDVIAEDLRRG 720
Query: 721 VQILMQAAGLGRMKPNILVVGFKKNWQSAHPATVEDYIGILHDAFDFNYGVCVMRMREGL 780
VQILMQAAGLGRMKPNILVVGFKKNWQSAHPATVEDYIGILHDAFDFNYGVCVMRMREGL
Sbjct: 721 VQILMQAAGLGRMKPNILVVGFKKNWQSAHPATVEDYIGILHDAFDFNYGVCVMRMREGL 780
Query: 781 NVSKMMQAHINPVFDPAEDGKEASARGARPSVSGALDPKALVKEEQATTIFQSEQGKKTI 840
NVSKMMQAHINPVFDPAEDGKEASAR +DPKALVKEEQATTIFQSEQGKKTI
Sbjct: 781 NVSKMMQAHINPVFDPAEDGKEASAR---------VDPKALVKEEQATTIFQSEQGKKTI 831
Query: 841 DIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRVFVGGQINRMDQERKAIISLLSKFRLGFH 900
DIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRVFVGGQINRMDQERKAIISLLSKFRLGFH
Sbjct: 832 DIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRVFVGGQINRMDQERKAIISLLSKFRLGFH 891
Query: 901 EVHILPDINQNPRAEHTKRFEDMIAPFRLNDGFKDEATVNEMRRDCPWKISDEEITKNRV 960
EVHILPDINQNPRAEHTKRFEDMIAPFRLNDGFKDEATVNEMRRDCPWKISDEEITKNRV
Sbjct: 892 EVHILPDINQNPRAEHTKRFEDMIAPFRLNDGFKDEATVNEMRRDCPWKISDEEITKNRV 951
Query: 961 KSLRQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLETLSQDLRPPVILIRGN 1020
KSLRQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLETLSQDLRPPVILIRGN
Sbjct: 952 KSLRQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLETLSQDLRPPVILIRGN 1011
Query: 1021 QENVLTFYCQ 1030
QENVLTFYCQ
Sbjct: 1012 QENVLTFYCQ 1021
>gi|4506975 solute carrier family 12 (sodium/potassium/chloride
transporters), member 2 [Homo sapiens]
Length = 1212
Score = 1074 bits (2777), Expect = 0.0
Identities = 536/1038 (51%), Positives = 728/1038 (70%), Gaps = 67/1038 (6%)
Query: 39 SSHPSHL---THSSTFCMRTFGYNTIDVVPTYEHYANSTQPGEPRKVRPTLADLHSFLKQ 95
S H H TH++T+ +RTFG+NT+D VP +HY ++ + +RP+LA+LH L++
Sbjct: 193 SGHHQHYYYDTHTNTYYLRTFGHNTMDAVPRIDHYRHTAAQLGEKLLRPSLAELHDELEK 252
Query: 96 EGRHLHALAFDSRPSHEMTDGLVEGEAGTSSEK-------NPEEPVRFGWVKGVMIRCML 148
E DG GE T + + V+FGW+KGV++RCML
Sbjct: 253 E---------------PFEDGFANGEESTPTRDAVVTYTAESKGVVKFGWIKGVLVRCML 297
Query: 149 NIWGVILYLRLPWITAQAGIVLTWIIILLSVTVTSITGLSISAISTNGKVKSGGTYFLIS 208
NIWGV+L++RL WI QAGI L+ ++I+++ VT+ITGLS SAI+TNG V+ GG Y+LIS
Sbjct: 298 NIWGVMLFIRLSWIVGQAGIGLSVLVIMMATVVTTITGLSTSAIATNGFVRGGGAYYLIS 357
Query: 209 RSLGPELGGSIGLIFAFANAVGVAMHTVGFAETVRDLLQEYGAPIVDPINDIRIIGVVSV 268
RSLGPE GG+IGLIFAFANAV VAM+ VGFAETV +LL+E+ ++D INDIRIIG ++V
Sbjct: 358 RSLGPEFGGAIGLIFAFANAVAVAMYVVGFAETVVELLKEHSILMIDEINDIRIIGAITV 417
Query: 269 TVLLAISLAGMEWESKAQVLFFLVIMVSFANYLVGTLIPPSEDKASKGFFSYRADIFVQN 328
+LL IS+AGMEWE+KAQ++ ++++++ ++++GT IP E K KGFF Y+++IF +N
Sbjct: 418 VILLGISVAGMEWEAKAQIVLLVILLLAIGDFVIGTFIP-LESKKPKGFFGYKSEIFNEN 476
Query: 329 LVPDWRGPDGTFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLA 388
PD+R + TFF +F+IFFP+ATGILAGANISGDL DP AIPKGTL+AI TT+ Y+
Sbjct: 477 FGPDFREEE-TFFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTLVYVG 535
Query: 389 ISATIGSCVVRDASGVLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMS 448
I+ ++GSCVVRDA+G +NDT+ C AC ++F+ C + C YGL+N +Q MS
Sbjct: 536 IAVSVGSCVVRDATGNVNDTIVTELTNCTSAACKLNFDFSSC-ESSPCSYGLMNNFQVMS 594
Query: 449 MVSGFAPLITAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRG 508
MVSGF PLI+AGIF ATLSSALA LVSA K+FQ LC+D +YP F KGYGKN EP+RG
Sbjct: 595 MVSGFTPLISAGIFSATLSSALASLVSAPKIFQALCKDNIYPAFQMFAKGYGKNNEPLRG 654
Query: 509 YLLAYAIAVAFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKW 568
Y+L + IA+ FI+IAELN IAPIISNFFL SYALINFS FHAS+ SPGWRP+F+YYN W
Sbjct: 655 YILTFLIALGFILIAELNVIAPIISNFFLASYALINFSVFHASLAKSPGWRPAFKYYNMW 714
Query: 569 AALFGAIISVVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYS 628
+L GAI+ ++MF++ WWAAL+ +VL L +YV YKKP+VNWGSS QA +Y AL +S
Sbjct: 715 ISLLGAILCCIVMFVINWWAALLTYVIVLGLYIYVTYKKPDVNWGSSTQALTYLNALQHS 774
Query: 629 VGLNEVEDHIKNYRPQCLVLTGPPNFRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPE 688
+ L+ VEDH+KN+RPQCLV+TG PN RPAL+ V FT+N+ LMICGHV +GP +Q M E
Sbjct: 775 IRLSGVEDHVKNFRPQCLVMTGAPNSRPALLHLVHDFTKNVGLMICGHVHMGPRRQAMKE 834
Query: 689 LQLIANGHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNWQS 748
+ + + +WL K K+KAFY+ V A+DLR G Q LMQAAGLGRMKPN LV+GFKK+W
Sbjct: 835 MSIDQAKYQRWLIKNKMKAFYAPVHADDLREGAQYLMQAAGLGRMKPNTLVLGFKKDWLQ 894
Query: 749 AHPATVEDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAH------------------- 789
A V+ YI + HDAFD YGV V+R++EGL++S +
Sbjct: 895 ADMRDVDMYINLFHDAFDIQYGVVVIRLKEGLDISHLQGQEELLSSQEKSPGTKDVVVSV 954
Query: 790 ----------INPVFD-------PAEDGKEASARGARPSVSGALDPKALVKEE--QATTI 830
P+ + EDGK A+ + G + P + ++ +A+T
Sbjct: 955 EYSKKSDLDTSKPLSEKPITHKVEEEDGKTATQPLLKKESKGPIVPLNVADQKLLEASTQ 1014
Query: 831 FQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRVFVGGQINRMDQERKAIIS 890
FQ +QGK TID++WLFDDGGLTLLIPYLL K++W CKIRVF+GG+INR+D +R+A+ +
Sbjct: 1015 FQKKQGKNTIDVWWLFDDGGLTLLIPYLLTTKKKWKDCKIRVFIGGKINRIDHDRRAMAT 1074
Query: 891 LLSKFRLGFHEVHILPDINQNPRAEHTKRFEDMIAPFRLNDGFKDEATVNEMRRDCPWKI 950
LLSKFR+ F ++ +L DIN P+ E+ FE++I P+RL++ K++ ++M+ D PW+I
Sbjct: 1075 LLSKFRIDFSDIMVLGDINTKPKKENIIAFEEIIEPYRLHEDDKEQDIADKMKEDEPWRI 1134
Query: 951 SDEEITKNRVKSLRQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLETLSQDL 1010
+D E+ + K+ RQ+RLNE++ ++S A +IV++LP+ RKG S+LYMAWLE LS+DL
Sbjct: 1135 TDNELELYKTKTYRQIRLNELLKEHSSTANIIVMSLPVARKGAVSSALYMAWLEALSKDL 1194
Query: 1011 RPPVILIRGNQENVLTFY 1028
PP++L+RGN ++VLTFY
Sbjct: 1195 -PPILLVRGNHQSVLTFY 1211
>gi|134254459 sodium potassium chloride cotransporter 2 [Homo sapiens]
Length = 1099
Score = 1061 bits (2743), Expect = 0.0
Identities = 533/1026 (51%), Positives = 720/1026 (70%), Gaps = 39/1026 (3%)
Query: 35 AAYDSSHPSHLTHSSTFCMRTFGYNTIDVVPTYEHYANSTQPGEPRKVRPTLADLHSFLK 94
A D+S ++ +H++T+ ++TFG+NT+D VP E+Y N+ P+ RP+L ++H L
Sbjct: 80 AKTDASFHAYDSHTNTYYLQTFGHNTMDAVPKIEYYRNTGSISGPKVNRPSLLEIHEQLA 139
Query: 95 QEGRHLHALAFDSRPSHEMTDGLVEGEAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVI 154
+ A+ S DG+ E + E + V+FGWVKGV++RCMLNIWGV+
Sbjct: 140 KNV----AVTPSSADRVANGDGIPGDEQAENKEDDQAGVVKFGWVKGVLVRCMLNIWGVM 195
Query: 155 LYLRLPWITAQAGIVLTWIIILLSVTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPE 214
L++RL WI +AGI L +IILLS VTSITGLS SAI+TNG V+ GG Y+LISRSLGPE
Sbjct: 196 LFIRLSWIVGEAGIGLGVLIILLSTMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPE 255
Query: 215 LGGSIGLIFAFANAVGVAMHTVGFAETVRDLLQEYGAPIVDPINDIRIIGVVSVTVLLAI 274
GGSIGLIFAFANAV VAM+ VGFAETV DLL+E + +VDP NDIRIIG ++V +LL I
Sbjct: 256 FGGSIGLIFAFANAVAVAMYVVGFAETVVDLLKESDSMMVDPTNDIRIIGSITVVILLGI 315
Query: 275 SLAGMEWESKAQVLFFLVIMVSFANYLVGTLIPPSEDKASKGFFSYRADIFVQNLVPDWR 334
S+AGMEWE+KAQV+ ++++++ AN+ +GT+IP + +K S+GFF+Y+A IF +N P +
Sbjct: 316 SVAGMEWEAKAQVILLVILLIAIANFFIGTVIPSNNEKKSRGFFNYQASIFAENFGPRFT 375
Query: 335 GPDGTFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIG 394
+G FF +F+IFFP+ATGILAGANISGDL+DP AIP+GT++AIF TT++YL ++ +G
Sbjct: 376 KGEG-FFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYLGVAICVG 434
Query: 395 SCVVRDASGVLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFA 454
+CVVRDA+G +NDT+ G AC G++F+ C + C YGL+N +Q MSMVSGF
Sbjct: 435 ACVVRDATGNMNDTIISGMNCNGSAACGLGYDFSRCRHE-PCQYGLMNNFQVMSMVSGFG 493
Query: 455 PLITAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYA 514
PLITAGIF ATLSSALA LVSA KVFQ LC+D +Y + FF KGYGKN EP+RGY+L +
Sbjct: 494 PLITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGKNNEPLRGYILTFL 553
Query: 515 IAVAFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFGA 574
IA+AFI+IAELNTIAPIISNFFL SYALINFSCFHAS SPGWRP++ YN W +LFGA
Sbjct: 554 IAMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGA 613
Query: 575 IISVVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEV 634
++ +MF++ WWAA+I + FL +YV KKP+VNWGSS QA SY AL ++ L V
Sbjct: 614 VLCCAVMFVINWWAAVITYVIEFFLYVYVTCKKPDVNWGSSTQALSYVSALDNALELTTV 673
Query: 635 EDHIKNYRPQCLVLTGPPNFRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPELQLIAN 694
EDH+KN+RPQC+VLTG P RPAL+D FT+N L IC V +GP K + E+
Sbjct: 674 EDHVKNFRPQCIVLTGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNSGMA 733
Query: 695 GHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNWQSAHPATV 754
WL K KIKAFY+ V A+ R GV+ L+QA+GLGRMKPN LV+G+KKNW+ A +
Sbjct: 734 KKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRKAPLTEI 793
Query: 755 EDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAHIN-------------PVFDPAEDGK 801
E+Y+GI+HDAFDF GV ++R+ +G ++S+++Q + D + +
Sbjct: 794 ENYVGIIHDAFDFEIGVVIVRISQGFDISQVLQVQEELERLEQERLALEATIKDNECEEE 853
Query: 802 EASARG------------ARPSVSGALDPKALV-------KEEQATTIFQSEQGKKTIDI 842
RG P G+++ + K +A+T F+ +Q K TID+
Sbjct: 854 SGGIRGLFKKAGKLNITKTTPKKDGSINTSQSMHVGEFNQKLVEASTQFKKKQEKGTIDV 913
Query: 843 YWLFDDGGLTLLIPYLLGRKRRWSKCKIRVFVGGQINRMDQERKAIISLLSKFRLGFHEV 902
+WLFDDGGLTLLIPY+L +++W CK+R++VGG+INR+++E+ + SLLSKFR+ F ++
Sbjct: 914 WWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGGKINRIEEEKIVMASLLSKFRIKFADI 973
Query: 903 HILPDINQNPRAEHTKRFEDMIAPFRLNDGFKDEATVNEMRRDCPWKISDEEITKNRVKS 962
HI+ DIN P E K FE+MI P+RL++ KD T +++R+ PWKI+D E+ + KS
Sbjct: 974 HIIGDINIRPNKESWKVFEEMIEPYRLHESCKDLTTAEKLKRETPWKITDAELEAVKEKS 1033
Query: 963 LRQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLETLSQDLRPPVILIRGNQE 1022
RQVRLNE++ ++SR A LIV++LP+ RKG LYMAWLE L+++L PPV+L+RGN +
Sbjct: 1034 YRQVRLNELLQEHSRAANLIVLSLPVARKGSISDLLYMAWLEILTKNL-PPVLLVRGNHK 1092
Query: 1023 NVLTFY 1028
NVLTFY
Sbjct: 1093 NVLTFY 1098
>gi|31881740 solute carrier family 12 (potassium/chloride
transporters), member 9 [Homo sapiens]
Length = 914
Score = 248 bits (634), Expect = 2e-65
Identities = 173/639 (27%), Positives = 320/639 (50%), Gaps = 86/639 (13%)
Query: 141 GVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLSVTVTSITGLSISAISTNGKVKS 200
GV++ +L+++ ++++LR+ ++ AG++ ++L++ + ++T LS+ AI+TNG V+
Sbjct: 42 GVVVPTVLSMFSIVVFLRIGFVVGHAGLLQALAMLLVAYFILALTVLSVCAIATNGAVQG 101
Query: 201 GGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAETVRDLLQEYGAPIVDPINDI 260
GG YF+ISR+LGPE+GGSIGL+F AN G A+ +G E+V D+ +GA P + +
Sbjct: 102 GGAYFMISRTLGPEVGGSIGLMFYLANVCGCAVSLLGLVESVLDV---FGADATGP-SGL 157
Query: 261 RII----------GVVSVTVLLAISLAGMEWESKAQVLFFLVIMVSFANYLV-------- 302
R++ G + + ++ + G ++A L FL++ S A+ L+
Sbjct: 158 RVLPQGYGWNLLYGSLLLGLVGGVCTLGAGLYARASFLTFLLVSGSLASVLISFVAVGPR 217
Query: 303 -----------GTLIPPSEDKASKGFFSYRADIFVQNLVPDW-----RGPDGTFFGMFSI 346
G+ +PP F + + NL + G F +F++
Sbjct: 218 DIRLTPRPGPNGSSLPPRFGH----FTGFNSSTLKDNLGAGYAEDYTTGAVMNFASVFAV 273
Query: 347 FFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSCVVRDASGVLN 406
F TGI+AGAN+SG+LKDP+ AIP GT++A+ +T Y+ + S D + +
Sbjct: 274 LFNGCTGIMAGANMSGELKDPSRAIPLGTIVAVAYTFFVYVLLFFL--SSFTCDRTLLQE 331
Query: 407 DTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAPLITAGIFGATL 466
D YG +++ +S+ + PL+ GI+ L
Sbjct: 332 D---------------YG------------------FFRAISL---WPPLVLIGIYATAL 355
Query: 467 SSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAVAFIIIAELN 526
S++++ L+ A+++ L D L+ +I K + P L ++ + ++ +LN
Sbjct: 356 SASMSSLIGASRILHALARDDLFGVILAPAKVVSRGGNPWAAVLYSWGLVQLVLLAGKLN 415
Query: 527 TIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIISVVIMFLLTW 586
T+A +++ F+L +YA ++ SC ++P +RP+F ++ L G +++MFL++
Sbjct: 416 TLAAVVTVFYLVAYAAVDLSCLSLEWASAPNFRPTFSLFSWHTCLLGVASCLLMMFLISP 475
Query: 587 WAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDHIKNYRPQCL 646
AA ++ ++ L + + +WG QA ++ Y + L+ +DH+K +RPQ L
Sbjct: 476 GAAGGSLLLMGLLAALLTARGGPSSWGYVSQALLFHQVRKYLLRLDVRKDHVKFWRPQLL 535
Query: 647 VLTGPPNFRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPELQLIANGHTKWL---NKR 703
+L G P L+ + L + GHV +G +P + + WL ++
Sbjct: 536 LLVGNPRGALPLLRLANQLKKG-GLYVLGHVTLG-DLDSLPS-DPVQPQYGAWLSLVDRA 592
Query: 704 KIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGF 742
++KAF ++ +R+G Q L++ +GLG MKPN LV+GF
Sbjct: 593 QVKAFVDLTLSPSVRQGAQHLLRISGLGGMKPNTLVLGF 631
>gi|110224458 solute carrier family 12, member 6 isoform e [Homo
sapiens]
Length = 1135
Score = 236 bits (601), Expect = 1e-61
Identities = 199/752 (26%), Positives = 328/752 (43%), Gaps = 148/752 (19%)
Query: 339 TFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSC-- 396
+F + IFFPS TGI+AG+N SGDLKD +IP GT++AI T+ YL+ G+C
Sbjct: 469 SFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIE 528
Query: 397 --VVRDASG-VLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGF 453
V+RD G + + G T+S S +
Sbjct: 529 GVVLRDKFGDAVKGNLVVG---------------------------------TLSWPSPW 555
Query: 454 APLITAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAY 513
+I G F +T + L L A ++ Q + +D + P + FG N EP LL
Sbjct: 556 --VIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKA-NGEPTWALLLTA 612
Query: 514 AIAVAFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFG 573
AIA I+IA L+ +API+S FFL Y +N +C ++ +P WRP F+YY+ + G
Sbjct: 613 AIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMG 672
Query: 574 AIISVVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNE 633
I + +MF+ +W+ A++A+ + + Y+ Y+ E WG ++ S + A + L E
Sbjct: 673 MSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEE 732
Query: 634 VEDHIKNYRPQCLVLTGPPN----FRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPEL 689
H KN+RPQ LVL P L+ F L I G V++G + E
Sbjct: 733 GPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEA 792
Query: 690 QLIANGHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNWQSA 749
+ K+K F V+A LR G+ L+Q+ GLG MK N +V+G+ W+ +
Sbjct: 793 LAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQS 852
Query: 750 HPATV-EDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAHINPVFDPAEDGKEASARGA 808
A + +IG +R+ +++ ++ +I+ F P
Sbjct: 853 EDARAWKTFIG-------------TVRVTTAAHLALLVAKNIS--FFP------------ 885
Query: 809 RPSVSGALDPKALVKEEQATTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWSKC 868
+ + Q +G ID++W+ DGG+ +L+P+LL + + W KC
Sbjct: 886 -------------------SNVEQFSEG--NIDVWWIVHDGGMLMLLPFLLKQHKVWRKC 924
Query: 869 KIRVFVGGQI-NRMDQERKAIISLLSKFRLGFHEVHILPDINQNPRA---EHTKRFE--- 921
IR+F Q+ + Q +K + + L R+ EV ++ + + A E T E
Sbjct: 925 SIRIFTVAQLEDNSIQMKKDLATFLYHLRIE-AEVEVVEMHDSDISAYTYERTLMMEQRS 983
Query: 922 DMIAPFRLNDGFKDEATVNEMRRDCPWKIS------DEEI-----------TKNRVKSLR 964
M+ RL+ +D R+ +++ DEE TK++ + R
Sbjct: 984 QMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASR 1043
Query: 965 ----------------------------QVRLNEIVLDYSRDAALIVITLPIGRKGKCPS 996
V+LNE++++ S +A L+++ +P +
Sbjct: 1044 GQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGD 1103
Query: 997 SLYMAWLETLSQDLRPPVILIRGNQENVLTFY 1028
YM +LE L++ L V+L+RG V+T Y
Sbjct: 1104 ENYMEFLEVLTEGLE-RVLLVRGGGSEVITIY 1134
Score = 123 bits (308), Expect = 1e-27
Identities = 69/207 (33%), Positives = 112/207 (54%), Gaps = 21/207 (10%)
Query: 119 EGEAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLS 178
E E T +K P + + G GV + C+ NI+GVIL+LRL W+ AG++ + I+L+
Sbjct: 153 EAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLIC 212
Query: 179 VTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGF 238
T +T +S+SAI+TNG V +GG+YF+ISR+LGPE GG++GL F AM+ +G
Sbjct: 213 CCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGA 272
Query: 239 AETV-------------RDLLQEYGAPIVDPINDIRIIGVVSVTVLLAISLAGMEWESKA 285
E D L+E A +N++R+ G + +++ + G+ + +K
Sbjct: 273 IEIFLVYIVPRAAIFHSDDALKESAA----MLNNMRVYGTAFLVLMVLVVFIGVRYVNKF 328
Query: 286 QVLFFLVIMVS----FANYLVGTLIPP 308
LF ++VS +A + + PP
Sbjct: 329 ASLFLACVIVSILAIYAGAIKSSFAPP 355
>gi|110224456 solute carrier family 12, member 6 isoform d [Homo
sapiens]
Length = 1141
Score = 236 bits (601), Expect = 1e-61
Identities = 199/752 (26%), Positives = 328/752 (43%), Gaps = 148/752 (19%)
Query: 339 TFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSC-- 396
+F + IFFPS TGI+AG+N SGDLKD +IP GT++AI T+ YL+ G+C
Sbjct: 475 SFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIE 534
Query: 397 --VVRDASG-VLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGF 453
V+RD G + + G T+S S +
Sbjct: 535 GVVLRDKFGDAVKGNLVVG---------------------------------TLSWPSPW 561
Query: 454 APLITAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAY 513
+I G F +T + L L A ++ Q + +D + P + FG N EP LL
Sbjct: 562 --VIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKA-NGEPTWALLLTA 618
Query: 514 AIAVAFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFG 573
AIA I+IA L+ +API+S FFL Y +N +C ++ +P WRP F+YY+ + G
Sbjct: 619 AIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMG 678
Query: 574 AIISVVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNE 633
I + +MF+ +W+ A++A+ + + Y+ Y+ E WG ++ S + A + L E
Sbjct: 679 MSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEE 738
Query: 634 VEDHIKNYRPQCLVLTGPPN----FRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPEL 689
H KN+RPQ LVL P L+ F L I G V++G + E
Sbjct: 739 GPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEA 798
Query: 690 QLIANGHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNWQSA 749
+ K+K F V+A LR G+ L+Q+ GLG MK N +V+G+ W+ +
Sbjct: 799 LAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQS 858
Query: 750 HPATV-EDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAHINPVFDPAEDGKEASARGA 808
A + +IG +R+ +++ ++ +I+ F P
Sbjct: 859 EDARAWKTFIG-------------TVRVTTAAHLALLVAKNIS--FFP------------ 891
Query: 809 RPSVSGALDPKALVKEEQATTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWSKC 868
+ + Q +G ID++W+ DGG+ +L+P+LL + + W KC
Sbjct: 892 -------------------SNVEQFSEG--NIDVWWIVHDGGMLMLLPFLLKQHKVWRKC 930
Query: 869 KIRVFVGGQI-NRMDQERKAIISLLSKFRLGFHEVHILPDINQNPRA---EHTKRFE--- 921
IR+F Q+ + Q +K + + L R+ EV ++ + + A E T E
Sbjct: 931 SIRIFTVAQLEDNSIQMKKDLATFLYHLRIE-AEVEVVEMHDSDISAYTYERTLMMEQRS 989
Query: 922 DMIAPFRLNDGFKDEATVNEMRRDCPWKIS------DEEI-----------TKNRVKSLR 964
M+ RL+ +D R+ +++ DEE TK++ + R
Sbjct: 990 QMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASR 1049
Query: 965 ----------------------------QVRLNEIVLDYSRDAALIVITLPIGRKGKCPS 996
V+LNE++++ S +A L+++ +P +
Sbjct: 1050 GQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGD 1109
Query: 997 SLYMAWLETLSQDLRPPVILIRGNQENVLTFY 1028
YM +LE L++ L V+L+RG V+T Y
Sbjct: 1110 ENYMEFLEVLTEGLE-RVLLVRGGGSEVITIY 1140
Score = 123 bits (308), Expect = 1e-27
Identities = 69/207 (33%), Positives = 112/207 (54%), Gaps = 21/207 (10%)
Query: 119 EGEAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLS 178
E E T +K P + + G GV + C+ NI+GVIL+LRL W+ AG++ + I+L+
Sbjct: 159 EAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLIC 218
Query: 179 VTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGF 238
T +T +S+SAI+TNG V +GG+YF+ISR+LGPE GG++GL F AM+ +G
Sbjct: 219 CCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGA 278
Query: 239 AETV-------------RDLLQEYGAPIVDPINDIRIIGVVSVTVLLAISLAGMEWESKA 285
E D L+E A +N++R+ G + +++ + G+ + +K
Sbjct: 279 IEIFLVYIVPRAAIFHSDDALKESAA----MLNNMRVYGTAFLVLMVLVVFIGVRYVNKF 334
Query: 286 QVLFFLVIMVS----FANYLVGTLIPP 308
LF ++VS +A + + PP
Sbjct: 335 ASLFLACVIVSILAIYAGAIKSSFAPP 361
>gi|110224454 solute carrier family 12, member 6 isoform c [Homo
sapiens]
Length = 1091
Score = 236 bits (601), Expect = 1e-61
Identities = 199/752 (26%), Positives = 328/752 (43%), Gaps = 148/752 (19%)
Query: 339 TFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSC-- 396
+F + IFFPS TGI+AG+N SGDLKD +IP GT++AI T+ YL+ G+C
Sbjct: 425 SFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIE 484
Query: 397 --VVRDASG-VLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGF 453
V+RD G + + G T+S S +
Sbjct: 485 GVVLRDKFGDAVKGNLVVG---------------------------------TLSWPSPW 511
Query: 454 APLITAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAY 513
+I G F +T + L L A ++ Q + +D + P + FG N EP LL
Sbjct: 512 --VIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKA-NGEPTWALLLTA 568
Query: 514 AIAVAFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFG 573
AIA I+IA L+ +API+S FFL Y +N +C ++ +P WRP F+YY+ + G
Sbjct: 569 AIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMG 628
Query: 574 AIISVVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNE 633
I + +MF+ +W+ A++A+ + + Y+ Y+ E WG ++ S + A + L E
Sbjct: 629 MSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEE 688
Query: 634 VEDHIKNYRPQCLVLTGPPN----FRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPEL 689
H KN+RPQ LVL P L+ F L I G V++G + E
Sbjct: 689 GPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEA 748
Query: 690 QLIANGHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNWQSA 749
+ K+K F V+A LR G+ L+Q+ GLG MK N +V+G+ W+ +
Sbjct: 749 LAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQS 808
Query: 750 HPATV-EDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAHINPVFDPAEDGKEASARGA 808
A + +IG +R+ +++ ++ +I+ F P
Sbjct: 809 EDARAWKTFIG-------------TVRVTTAAHLALLVAKNIS--FFP------------ 841
Query: 809 RPSVSGALDPKALVKEEQATTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWSKC 868
+ + Q +G ID++W+ DGG+ +L+P+LL + + W KC
Sbjct: 842 -------------------SNVEQFSEG--NIDVWWIVHDGGMLMLLPFLLKQHKVWRKC 880
Query: 869 KIRVFVGGQI-NRMDQERKAIISLLSKFRLGFHEVHILPDINQNPRA---EHTKRFE--- 921
IR+F Q+ + Q +K + + L R+ EV ++ + + A E T E
Sbjct: 881 SIRIFTVAQLEDNSIQMKKDLATFLYHLRIE-AEVEVVEMHDSDISAYTYERTLMMEQRS 939
Query: 922 DMIAPFRLNDGFKDEATVNEMRRDCPWKIS------DEEI-----------TKNRVKSLR 964
M+ RL+ +D R+ +++ DEE TK++ + R
Sbjct: 940 QMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASR 999
Query: 965 ----------------------------QVRLNEIVLDYSRDAALIVITLPIGRKGKCPS 996
V+LNE++++ S +A L+++ +P +
Sbjct: 1000 GQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGD 1059
Query: 997 SLYMAWLETLSQDLRPPVILIRGNQENVLTFY 1028
YM +LE L++ L V+L+RG V+T Y
Sbjct: 1060 ENYMEFLEVLTEGLE-RVLLVRGGGSEVITIY 1090
Score = 123 bits (308), Expect = 1e-27
Identities = 69/207 (33%), Positives = 112/207 (54%), Gaps = 21/207 (10%)
Query: 119 EGEAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLS 178
E E T +K P + + G GV + C+ NI+GVIL+LRL W+ AG++ + I+L+
Sbjct: 109 EAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLIC 168
Query: 179 VTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGF 238
T +T +S+SAI+TNG V +GG+YF+ISR+LGPE GG++GL F AM+ +G
Sbjct: 169 CCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGA 228
Query: 239 AETV-------------RDLLQEYGAPIVDPINDIRIIGVVSVTVLLAISLAGMEWESKA 285
E D L+E A +N++R+ G + +++ + G+ + +K
Sbjct: 229 IEIFLVYIVPRAAIFHSDDALKESAA----MLNNMRVYGTAFLVLMVLVVFIGVRYVNKF 284
Query: 286 QVLFFLVIMVS----FANYLVGTLIPP 308
LF ++VS +A + + PP
Sbjct: 285 ASLFLACVIVSILAIYAGAIKSSFAPP 311
>gi|110224452 solute carrier family 12, member 6 isoform c [Homo
sapiens]
Length = 1091
Score = 236 bits (601), Expect = 1e-61
Identities = 199/752 (26%), Positives = 328/752 (43%), Gaps = 148/752 (19%)
Query: 339 TFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSC-- 396
+F + IFFPS TGI+AG+N SGDLKD +IP GT++AI T+ YL+ G+C
Sbjct: 425 SFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIE 484
Query: 397 --VVRDASG-VLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGF 453
V+RD G + + G T+S S +
Sbjct: 485 GVVLRDKFGDAVKGNLVVG---------------------------------TLSWPSPW 511
Query: 454 APLITAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAY 513
+I G F +T + L L A ++ Q + +D + P + FG N EP LL
Sbjct: 512 --VIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKA-NGEPTWALLLTA 568
Query: 514 AIAVAFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFG 573
AIA I+IA L+ +API+S FFL Y +N +C ++ +P WRP F+YY+ + G
Sbjct: 569 AIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMG 628
Query: 574 AIISVVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNE 633
I + +MF+ +W+ A++A+ + + Y+ Y+ E WG ++ S + A + L E
Sbjct: 629 MSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEE 688
Query: 634 VEDHIKNYRPQCLVLTGPPN----FRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPEL 689
H KN+RPQ LVL P L+ F L I G V++G + E
Sbjct: 689 GPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEA 748
Query: 690 QLIANGHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNWQSA 749
+ K+K F V+A LR G+ L+Q+ GLG MK N +V+G+ W+ +
Sbjct: 749 LAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQS 808
Query: 750 HPATV-EDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAHINPVFDPAEDGKEASARGA 808
A + +IG +R+ +++ ++ +I+ F P
Sbjct: 809 EDARAWKTFIG-------------TVRVTTAAHLALLVAKNIS--FFP------------ 841
Query: 809 RPSVSGALDPKALVKEEQATTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWSKC 868
+ + Q +G ID++W+ DGG+ +L+P+LL + + W KC
Sbjct: 842 -------------------SNVEQFSEG--NIDVWWIVHDGGMLMLLPFLLKQHKVWRKC 880
Query: 869 KIRVFVGGQI-NRMDQERKAIISLLSKFRLGFHEVHILPDINQNPRA---EHTKRFE--- 921
IR+F Q+ + Q +K + + L R+ EV ++ + + A E T E
Sbjct: 881 SIRIFTVAQLEDNSIQMKKDLATFLYHLRIE-AEVEVVEMHDSDISAYTYERTLMMEQRS 939
Query: 922 DMIAPFRLNDGFKDEATVNEMRRDCPWKIS------DEEI-----------TKNRVKSLR 964
M+ RL+ +D R+ +++ DEE TK++ + R
Sbjct: 940 QMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASR 999
Query: 965 ----------------------------QVRLNEIVLDYSRDAALIVITLPIGRKGKCPS 996
V+LNE++++ S +A L+++ +P +
Sbjct: 1000 GQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGD 1059
Query: 997 SLYMAWLETLSQDLRPPVILIRGNQENVLTFY 1028
YM +LE L++ L V+L+RG V+T Y
Sbjct: 1060 ENYMEFLEVLTEGLE-RVLLVRGGGSEVITIY 1090
Score = 123 bits (308), Expect = 1e-27
Identities = 69/207 (33%), Positives = 112/207 (54%), Gaps = 21/207 (10%)
Query: 119 EGEAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLS 178
E E T +K P + + G GV + C+ NI+GVIL+LRL W+ AG++ + I+L+
Sbjct: 109 EAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLIC 168
Query: 179 VTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGF 238
T +T +S+SAI+TNG V +GG+YF+ISR+LGPE GG++GL F AM+ +G
Sbjct: 169 CCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGA 228
Query: 239 AETV-------------RDLLQEYGAPIVDPINDIRIIGVVSVTVLLAISLAGMEWESKA 285
E D L+E A +N++R+ G + +++ + G+ + +K
Sbjct: 229 IEIFLVYIVPRAAIFHSDDALKESAA----MLNNMRVYGTAFLVLMVLVVFIGVRYVNKF 284
Query: 286 QVLFFLVIMVS----FANYLVGTLIPP 308
LF ++VS +A + + PP
Sbjct: 285 ASLFLACVIVSILAIYAGAIKSSFAPP 311
>gi|4826780 solute carrier family 12, member 6 isoform b [Homo
sapiens]
Length = 1099
Score = 236 bits (601), Expect = 1e-61
Identities = 199/752 (26%), Positives = 328/752 (43%), Gaps = 148/752 (19%)
Query: 339 TFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSC-- 396
+F + IFFPS TGI+AG+N SGDLKD +IP GT++AI T+ YL+ G+C
Sbjct: 433 SFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIE 492
Query: 397 --VVRDASG-VLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGF 453
V+RD G + + G T+S S +
Sbjct: 493 GVVLRDKFGDAVKGNLVVG---------------------------------TLSWPSPW 519
Query: 454 APLITAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAY 513
+I G F +T + L L A ++ Q + +D + P + FG N EP LL
Sbjct: 520 --VIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKA-NGEPTWALLLTA 576
Query: 514 AIAVAFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFG 573
AIA I+IA L+ +API+S FFL Y +N +C ++ +P WRP F+YY+ + G
Sbjct: 577 AIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMG 636
Query: 574 AIISVVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNE 633
I + +MF+ +W+ A++A+ + + Y+ Y+ E WG ++ S + A + L E
Sbjct: 637 MSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEE 696
Query: 634 VEDHIKNYRPQCLVLTGPPN----FRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPEL 689
H KN+RPQ LVL P L+ F L I G V++G + E
Sbjct: 697 GPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEA 756
Query: 690 QLIANGHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNWQSA 749
+ K+K F V+A LR G+ L+Q+ GLG MK N +V+G+ W+ +
Sbjct: 757 LAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQS 816
Query: 750 HPATV-EDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAHINPVFDPAEDGKEASARGA 808
A + +IG +R+ +++ ++ +I+ F P
Sbjct: 817 EDARAWKTFIG-------------TVRVTTAAHLALLVAKNIS--FFP------------ 849
Query: 809 RPSVSGALDPKALVKEEQATTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWSKC 868
+ + Q +G ID++W+ DGG+ +L+P+LL + + W KC
Sbjct: 850 -------------------SNVEQFSEG--NIDVWWIVHDGGMLMLLPFLLKQHKVWRKC 888
Query: 869 KIRVFVGGQI-NRMDQERKAIISLLSKFRLGFHEVHILPDINQNPRA---EHTKRFE--- 921
IR+F Q+ + Q +K + + L R+ EV ++ + + A E T E
Sbjct: 889 SIRIFTVAQLEDNSIQMKKDLATFLYHLRIE-AEVEVVEMHDSDISAYTYERTLMMEQRS 947
Query: 922 DMIAPFRLNDGFKDEATVNEMRRDCPWKIS------DEEI-----------TKNRVKSLR 964
M+ RL+ +D R+ +++ DEE TK++ + R
Sbjct: 948 QMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASR 1007
Query: 965 ----------------------------QVRLNEIVLDYSRDAALIVITLPIGRKGKCPS 996
V+LNE++++ S +A L+++ +P +
Sbjct: 1008 GQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGD 1067
Query: 997 SLYMAWLETLSQDLRPPVILIRGNQENVLTFY 1028
YM +LE L++ L V+L+RG V+T Y
Sbjct: 1068 ENYMEFLEVLTEGLE-RVLLVRGGGSEVITIY 1098
Score = 123 bits (308), Expect = 1e-27
Identities = 69/207 (33%), Positives = 112/207 (54%), Gaps = 21/207 (10%)
Query: 119 EGEAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLS 178
E E T +K P + + G GV + C+ NI+GVIL+LRL W+ AG++ + I+L+
Sbjct: 117 EAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLIC 176
Query: 179 VTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGF 238
T +T +S+SAI+TNG V +GG+YF+ISR+LGPE GG++GL F AM+ +G
Sbjct: 177 CCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGA 236
Query: 239 AETV-------------RDLLQEYGAPIVDPINDIRIIGVVSVTVLLAISLAGMEWESKA 285
E D L+E A +N++R+ G + +++ + G+ + +K
Sbjct: 237 IEIFLVYIVPRAAIFHSDDALKESAA----MLNNMRVYGTAFLVLMVLVVFIGVRYVNKF 292
Query: 286 QVLFFLVIMVS----FANYLVGTLIPP 308
LF ++VS +A + + PP
Sbjct: 293 ASLFLACVIVSILAIYAGAIKSSFAPP 319
>gi|110224449 solute carrier family 12, member 6 isoform a [Homo
sapiens]
Length = 1150
Score = 236 bits (601), Expect = 1e-61
Identities = 199/752 (26%), Positives = 328/752 (43%), Gaps = 148/752 (19%)
Query: 339 TFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSC-- 396
+F + IFFPS TGI+AG+N SGDLKD +IP GT++AI T+ YL+ G+C
Sbjct: 484 SFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIE 543
Query: 397 --VVRDASG-VLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGF 453
V+RD G + + G T+S S +
Sbjct: 544 GVVLRDKFGDAVKGNLVVG---------------------------------TLSWPSPW 570
Query: 454 APLITAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAY 513
+I G F +T + L L A ++ Q + +D + P + FG N EP LL
Sbjct: 571 --VIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKA-NGEPTWALLLTA 627
Query: 514 AIAVAFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFG 573
AIA I+IA L+ +API+S FFL Y +N +C ++ +P WRP F+YY+ + G
Sbjct: 628 AIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMG 687
Query: 574 AIISVVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNE 633
I + +MF+ +W+ A++A+ + + Y+ Y+ E WG ++ S + A + L E
Sbjct: 688 MSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEE 747
Query: 634 VEDHIKNYRPQCLVLTGPPN----FRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPEL 689
H KN+RPQ LVL P L+ F L I G V++G + E
Sbjct: 748 GPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEA 807
Query: 690 QLIANGHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNWQSA 749
+ K+K F V+A LR G+ L+Q+ GLG MK N +V+G+ W+ +
Sbjct: 808 LAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQS 867
Query: 750 HPATV-EDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAHINPVFDPAEDGKEASARGA 808
A + +IG +R+ +++ ++ +I+ F P
Sbjct: 868 EDARAWKTFIG-------------TVRVTTAAHLALLVAKNIS--FFP------------ 900
Query: 809 RPSVSGALDPKALVKEEQATTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWSKC 868
+ + Q +G ID++W+ DGG+ +L+P+LL + + W KC
Sbjct: 901 -------------------SNVEQFSEG--NIDVWWIVHDGGMLMLLPFLLKQHKVWRKC 939
Query: 869 KIRVFVGGQI-NRMDQERKAIISLLSKFRLGFHEVHILPDINQNPRA---EHTKRFE--- 921
IR+F Q+ + Q +K + + L R+ EV ++ + + A E T E
Sbjct: 940 SIRIFTVAQLEDNSIQMKKDLATFLYHLRIE-AEVEVVEMHDSDISAYTYERTLMMEQRS 998
Query: 922 DMIAPFRLNDGFKDEATVNEMRRDCPWKIS------DEEI-----------TKNRVKSLR 964
M+ RL+ +D R+ +++ DEE TK++ + R
Sbjct: 999 QMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASR 1058
Query: 965 ----------------------------QVRLNEIVLDYSRDAALIVITLPIGRKGKCPS 996
V+LNE++++ S +A L+++ +P +
Sbjct: 1059 GQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGD 1118
Query: 997 SLYMAWLETLSQDLRPPVILIRGNQENVLTFY 1028
YM +LE L++ L V+L+RG V+T Y
Sbjct: 1119 ENYMEFLEVLTEGLE-RVLLVRGGGSEVITIY 1149
Score = 123 bits (308), Expect = 1e-27
Identities = 69/207 (33%), Positives = 112/207 (54%), Gaps = 21/207 (10%)
Query: 119 EGEAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLS 178
E E T +K P + + G GV + C+ NI+GVIL+LRL W+ AG++ + I+L+
Sbjct: 168 EAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLIC 227
Query: 179 VTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGF 238
T +T +S+SAI+TNG V +GG+YF+ISR+LGPE GG++GL F AM+ +G
Sbjct: 228 CCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGA 287
Query: 239 AETV-------------RDLLQEYGAPIVDPINDIRIIGVVSVTVLLAISLAGMEWESKA 285
E D L+E A +N++R+ G + +++ + G+ + +K
Sbjct: 288 IEIFLVYIVPRAAIFHSDDALKESAA----MLNNMRVYGTAFLVLMVLVVFIGVRYVNKF 343
Query: 286 QVLFFLVIMVS----FANYLVGTLIPP 308
LF ++VS +A + + PP
Sbjct: 344 ASLFLACVIVSILAIYAGAIKSSFAPP 370
>gi|123701900 solute carrier family 12 (potassium/chloride
transporters), member 7 [Homo sapiens]
Length = 1083
Score = 234 bits (597), Expect = 3e-61
Identities = 192/746 (25%), Positives = 319/746 (42%), Gaps = 138/746 (18%)
Query: 339 TFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSCVV 398
+F + I+FPS TGI+AG+N SGDLKD +IP GT++AI T+ YL+ G+C+
Sbjct: 419 SFTLLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILAIVTTSFIYLSCIVLFGACI- 477
Query: 399 RDASGVLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAP-LI 457
VL D F E Q + + M++ +P +I
Sbjct: 478 --EGVVLRD------------------KFGEALQGNL----------VIGMLAWPSPWVI 507
Query: 458 TAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAV 517
G F +T + L L A ++ Q + D + P + FG G N EP LL I
Sbjct: 508 VIGSFFSTCGAGLQSLTGAPRLLQAIARDGIVPFLQVFGHGKA-NGEPTWALLLTVLICE 566
Query: 518 AFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIIS 577
I+IA L+++API+S FFL Y +N +C ++ +P WRP F++Y+ + G +
Sbjct: 567 TGILIASLDSVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKFYHWTLSFLGMSLC 626
Query: 578 VVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDH 637
+ +MF+ +W+ AL A+ + + Y+ Y+ E WG ++ S N A + + H
Sbjct: 627 LALMFICSWYYALSAMLIAGCIYKYIEYRGAEKEWGDGIRGLSLNAARYALLRVEHGPPH 686
Query: 638 IKNYRPQCLVLTG----PPNFRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPELQLIA 693
KN+RPQ LV+ P L+ F L I G VL G + + E Q
Sbjct: 687 TKNWRPQVLVMLNLDAEQAVKHPRLLSFTSQLKAGKGLTIVGSVLEGTYLDKHMEAQRAE 746
Query: 694 NGHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNW-QSAHPA 752
++ K K F V++ LR G+ L+Q+AGLG +K N +++ + +W Q +P
Sbjct: 747 ENIRSLMSTEKTKGFCQLVVSSSLRDGMSHLIQSAGLGGLKHNTVLMAWPASWKQEDNPF 806
Query: 753 TVEDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAHINPVFDPAEDGKEASARGARPSV 812
+ ++++ + D + + V + NV Q
Sbjct: 807 SWKNFVDTVRDTTAAHQALLVAK-----NVDSFPQN------------------------ 837
Query: 813 SGALDPKALVKEEQATTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRV 872
Q G ID++W+ DGG+ +L+P+LL + + W KC++R+
Sbjct: 838 -------------------QERFGGGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRI 878
Query: 873 FVGGQI-NRMDQERKAIISLLSKFRLGFHEVHILPDINQNPRA---EHTKRFE---DMIA 925
F Q+ + Q +K + L R+ EV ++ + + A E T E M+
Sbjct: 879 FTVAQVDDNSIQMKKDLQMFLYHLRIS-AEVEVVEMVENDISAFTYERTLMMEQRSQMLK 937
Query: 926 PFRLNDGFKDEA------------TVNEMRRDCPWKISDEEITKNRVKSLRQ-------- 965
+L+ ++ T R P ++T R K + +
Sbjct: 938 QMQLSKNEQEREAQLIHDRNTASHTAAAARTQAPPTPDKVQMTWTREKLIAEKYRSRDTS 997
Query: 966 -----------------------VRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAW 1002
V+LN +VL+ S+DA L+++ +P K + YM +
Sbjct: 998 LSGFKDLFSMKPDQSNVRRMHTAVKLNGVVLNKSQDAQLVLLNMPGPPKNRQGDENYMEF 1057
Query: 1003 LETLSQDLRPPVILIRGNQENVLTFY 1028
LE L++ L V+L+RG V+T Y
Sbjct: 1058 LEVLTEGLN-RVLLVRGGGREVITIY 1082
Score = 125 bits (313), Expect = 3e-28
Identities = 74/253 (29%), Positives = 128/253 (50%), Gaps = 24/253 (9%)
Query: 77 GEPRKVRPTLADLH----SFLKQEGRHLHALAFDSRPS-----------HEMTDGLVEGE 121
G PR+ P L ++ SF + + L DS P ++ G+VE E
Sbjct: 44 GNPRENSPFLNNVEVEQESFFEGKNMALFEEEMDSNPMVSSLLNKLANYTNLSQGVVEHE 103
Query: 122 AGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLSVTV 181
S + + R G GV + C+ NI GVIL+LRL WI AG++ +++I+ + T
Sbjct: 104 EDEESRRREAKAPRMGTFIGVYLPCLQNILGVILFLRLTWIVGVAGVLESFLIVAMCCTC 163
Query: 182 TSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAET 241
T +T +S+SAI+TNG V +GG+Y++ISRSLGPE GG++GL F AM+ +G E
Sbjct: 164 TMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEI 223
Query: 242 VRDLL---------QEYGAPIVDPINDIRIIGVVSVTVLLAISLAGMEWESKAQVLFFLV 292
+ + G ++++R+ G ++ ++ + G+++ +K ++F
Sbjct: 224 FLTYISPGAAIFQAEAAGGEAAAMLHNMRVYGTCTLVLMALVVFVGVKYVNKLALVFLAC 283
Query: 293 IMVSFANYLVGTL 305
+++S G +
Sbjct: 284 VVLSILAIYAGVI 296
>gi|225579061 solute carrier family 12, member 4 isoform b [Homo
sapiens]
Length = 1079
Score = 233 bits (594), Expect = 7e-61
Identities = 194/741 (26%), Positives = 313/741 (42%), Gaps = 132/741 (17%)
Query: 339 TFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSCVV 398
+F + IFFPS TGI+AG+N SGDL+D +IP GT++AI T++ Y + G+C+
Sbjct: 419 SFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACI- 477
Query: 399 RDASGVLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAPLIT 458
VL D G G L T++ S + +I
Sbjct: 478 --EGVVLRDKY--GDGVSRNLVVG-----------------------TLAWPSPW--VIV 508
Query: 459 AGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAVA 518
G F +T + L L A ++ Q + +D + P + FG G N EP LL IA
Sbjct: 509 IGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGK-VNGEPTWALLLTALIAEL 567
Query: 519 FIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIISV 578
I+IA L+ +API+S FFL Y +N +C ++ +P WRP F+YY+ + G + +
Sbjct: 568 GILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCL 627
Query: 579 VIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDHI 638
+MF+ +W+ AL+A+ + + Y+ Y+ E WG ++ S + A + L E H
Sbjct: 628 ALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHT 687
Query: 639 KNYRPQCLVLTGPPN----FRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPELQLIAN 694
KN+RPQ LVL P L+ F L I G V+ G + E Q
Sbjct: 688 KNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQ 747
Query: 695 GHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNW-QSAHPAT 753
+ K+K F V+A +R G+ L+Q+ GLG M+ N +V+G+ W QS P
Sbjct: 748 TIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRA 807
Query: 754 VEDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAHINPVFDPAEDGKEASARGARPSVS 813
+ +I + C L V K N F P+ +
Sbjct: 808 WKTFIDTVR---------CTTAAHLALLVPK------NIAFYPSNHERYLEGH------- 845
Query: 814 GALDPKALVKEEQATTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRVF 873
ID++W+ DGG+ +L+P+LL + + W KC++R+F
Sbjct: 846 --------------------------IDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIF 879
Query: 874 VGGQIN-----------------RMDQERKAIISLLSKFRLGFHEVHI----LPDINQNP 912
Q++ R++ E + IS + R E + +
Sbjct: 880 TVAQMDDNSIQMKKDLAVFLYHLRLEAEHNSDISAYTYERTLMMEQRSQMLRQMRLTKTE 939
Query: 913 RAEHTKRFEDMIAPFRLNDGF---KDEATVNEMRRDCPWKISDEEITK------------ 957
R + +D + RL + +DE+ V + W D+ +T+
Sbjct: 940 REREAQLVKDRHSALRLESLYSDEEDESAVGADKIQMTW-TRDKYMTETWDPSHAPDNFR 998
Query: 958 ----------NRVKSLRQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLETLS 1007
N + V+LNE+++ S DA L+++ +P + YM +LE L+
Sbjct: 999 ELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLT 1058
Query: 1008 QDLRPPVILIRGNQENVLTFY 1028
+ L V+L+RG V+T Y
Sbjct: 1059 EGLE-RVLLVRGGGREVITIY 1078
Score = 125 bits (315), Expect = 2e-28
Identities = 69/198 (34%), Positives = 111/198 (56%), Gaps = 17/198 (8%)
Query: 119 EGEAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLS 178
E E+G + + E G + GV + C+ NI+GVIL+LRL W+ AG++ +I+L+
Sbjct: 101 EAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLIC 160
Query: 179 VTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGF 238
T +T +S+SAI+TNG V +GG+YF+ISRSLGPE GG++GL F AM+ +G
Sbjct: 161 CCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGA 220
Query: 239 AETVRDLLQEYGAP---IVDP----------INDIRIIGVVSVTVLLAISLAGMEWESKA 285
E +L Y AP I P +N++R+ G + +T + + G+++ +K
Sbjct: 221 IE----ILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKF 276
Query: 286 QVLFFLVIMVSFANYLVG 303
LF +++S + G
Sbjct: 277 ASLFLACVIISILSIYAG 294
>gi|225579067 solute carrier family 12, member 4 isoform e [Homo
sapiens]
Length = 1054
Score = 231 bits (588), Expect = 3e-60
Identities = 195/748 (26%), Positives = 314/748 (41%), Gaps = 140/748 (18%)
Query: 339 TFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSCVV 398
+F + IFFPS TGI+AG+N SGDL+D +IP GT++AI T++ Y + G+C+
Sbjct: 388 SFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACI- 446
Query: 399 RDASGVLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAPLIT 458
VL D G G L T++ S + +I
Sbjct: 447 --EGVVLRDKY--GDGVSRNLVVG-----------------------TLAWPSPW--VIV 477
Query: 459 AGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAVA 518
G F +T + L L A ++ Q + +D + P + FG G N EP LL IA
Sbjct: 478 IGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGK-VNGEPTWALLLTALIAEL 536
Query: 519 FIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIISV 578
I+IA L+ +API+S FFL Y +N +C ++ +P WRP F+YY+ + G + +
Sbjct: 537 GILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCL 596
Query: 579 VIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDHI 638
+MF+ +W+ AL+A+ + + Y+ Y+ E WG ++ S + A + L E H
Sbjct: 597 ALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHT 656
Query: 639 KNYRPQCLVLTGPPN----FRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPELQLIAN 694
KN+RPQ LVL P L+ F L I G V+ G + E Q
Sbjct: 657 KNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQ 716
Query: 695 GHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNW-QSAHPAT 753
+ K+K F V+A +R G+ L+Q+ GLG M+ N +V+G+ W QS P
Sbjct: 717 TIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRA 776
Query: 754 VEDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAHINPVFDPAEDGKEASARGARPSVS 813
+ +I + C L V K N F P+ +
Sbjct: 777 WKTFIDTVR---------CTTAAHLALLVPK------NIAFYPSNHERYLEGH------- 814
Query: 814 GALDPKALVKEEQATTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRVF 873
ID++W+ DGG+ +L+P+LL + + W KC++R+F
Sbjct: 815 --------------------------IDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIF 848
Query: 874 VGGQI-NRMDQERKAIISLLSKFRLGFHEVHILP-------------------------- 906
Q+ + Q +K + L RL EV ++
Sbjct: 849 TVAQMDDNSIQMKKDLAVFLYHLRLE-AEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQ 907
Query: 907 -DINQNPRAEHTKRFEDMIAPFRLNDGF---KDEATVNEMRRDCPWKISDEEITK----- 957
+ + R + +D + RL + +DE+ V + W D+ +T+
Sbjct: 908 MRLTKTEREREAQLVKDRHSALRLESLYSDEEDESAVGADKIQMTW-TRDKYMTETWDPS 966
Query: 958 -----------------NRVKSLRQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYM 1000
N + V+LNE+++ S DA L+++ +P + YM
Sbjct: 967 HAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYM 1026
Query: 1001 AWLETLSQDLRPPVILIRGNQENVLTFY 1028
+LE L++ L V+L+RG V+T Y
Sbjct: 1027 EFLEVLTEGLE-RVLLVRGGGREVITIY 1053
Score = 125 bits (315), Expect = 2e-28
Identities = 69/198 (34%), Positives = 111/198 (56%), Gaps = 17/198 (8%)
Query: 119 EGEAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLS 178
E E+G + + E G + GV + C+ NI+GVIL+LRL W+ AG++ +I+L+
Sbjct: 70 EAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLIC 129
Query: 179 VTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGF 238
T +T +S+SAI+TNG V +GG+YF+ISRSLGPE GG++GL F AM+ +G
Sbjct: 130 CCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGA 189
Query: 239 AETVRDLLQEYGAP---IVDP----------INDIRIIGVVSVTVLLAISLAGMEWESKA 285
E +L Y AP I P +N++R+ G + +T + + G+++ +K
Sbjct: 190 IE----ILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKF 245
Query: 286 QVLFFLVIMVSFANYLVG 303
LF +++S + G
Sbjct: 246 ASLFLACVIISILSIYAG 263
>gi|225579065 solute carrier family 12, member 4 isoform d [Homo
sapiens]
Length = 1079
Score = 231 bits (588), Expect = 3e-60
Identities = 195/748 (26%), Positives = 314/748 (41%), Gaps = 140/748 (18%)
Query: 339 TFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSCVV 398
+F + IFFPS TGI+AG+N SGDL+D +IP GT++AI T++ Y + G+C+
Sbjct: 413 SFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACI- 471
Query: 399 RDASGVLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAPLIT 458
VL D G G L T++ S + +I
Sbjct: 472 --EGVVLRDKY--GDGVSRNLVVG-----------------------TLAWPSPW--VIV 502
Query: 459 AGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAVA 518
G F +T + L L A ++ Q + +D + P + FG G N EP LL IA
Sbjct: 503 IGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGK-VNGEPTWALLLTALIAEL 561
Query: 519 FIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIISV 578
I+IA L+ +API+S FFL Y +N +C ++ +P WRP F+YY+ + G + +
Sbjct: 562 GILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCL 621
Query: 579 VIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDHI 638
+MF+ +W+ AL+A+ + + Y+ Y+ E WG ++ S + A + L E H
Sbjct: 622 ALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHT 681
Query: 639 KNYRPQCLVLTGPPN----FRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPELQLIAN 694
KN+RPQ LVL P L+ F L I G V+ G + E Q
Sbjct: 682 KNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQ 741
Query: 695 GHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNW-QSAHPAT 753
+ K+K F V+A +R G+ L+Q+ GLG M+ N +V+G+ W QS P
Sbjct: 742 TIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRA 801
Query: 754 VEDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAHINPVFDPAEDGKEASARGARPSVS 813
+ +I + C L V K N F P+ +
Sbjct: 802 WKTFIDTVR---------CTTAAHLALLVPK------NIAFYPSNHERYLEGH------- 839
Query: 814 GALDPKALVKEEQATTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRVF 873
ID++W+ DGG+ +L+P+LL + + W KC++R+F
Sbjct: 840 --------------------------IDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIF 873
Query: 874 VGGQI-NRMDQERKAIISLLSKFRLGFHEVHILP-------------------------- 906
Q+ + Q +K + L RL EV ++
Sbjct: 874 TVAQMDDNSIQMKKDLAVFLYHLRLE-AEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQ 932
Query: 907 -DINQNPRAEHTKRFEDMIAPFRLNDGF---KDEATVNEMRRDCPWKISDEEITK----- 957
+ + R + +D + RL + +DE+ V + W D+ +T+
Sbjct: 933 MRLTKTEREREAQLVKDRHSALRLESLYSDEEDESAVGADKIQMTW-TRDKYMTETWDPS 991
Query: 958 -----------------NRVKSLRQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYM 1000
N + V+LNE+++ S DA L+++ +P + YM
Sbjct: 992 HAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYM 1051
Query: 1001 AWLETLSQDLRPPVILIRGNQENVLTFY 1028
+LE L++ L V+L+RG V+T Y
Sbjct: 1052 EFLEVLTEGLE-RVLLVRGGGREVITIY 1078
Score = 125 bits (315), Expect = 2e-28
Identities = 69/198 (34%), Positives = 111/198 (56%), Gaps = 17/198 (8%)
Query: 119 EGEAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLS 178
E E+G + + E G + GV + C+ NI+GVIL+LRL W+ AG++ +I+L+
Sbjct: 95 EAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLIC 154
Query: 179 VTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGF 238
T +T +S+SAI+TNG V +GG+YF+ISRSLGPE GG++GL F AM+ +G
Sbjct: 155 CCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGA 214
Query: 239 AETVRDLLQEYGAP---IVDP----------INDIRIIGVVSVTVLLAISLAGMEWESKA 285
E +L Y AP I P +N++R+ G + +T + + G+++ +K
Sbjct: 215 IE----ILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKF 270
Query: 286 QVLFFLVIMVSFANYLVG 303
LF +++S + G
Sbjct: 271 ASLFLACVIISILSIYAG 288
>gi|225579063 solute carrier family 12, member 4 isoform c [Homo
sapiens]
Length = 1087
Score = 231 bits (588), Expect = 3e-60
Identities = 195/748 (26%), Positives = 314/748 (41%), Gaps = 140/748 (18%)
Query: 339 TFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSCVV 398
+F + IFFPS TGI+AG+N SGDL+D +IP GT++AI T++ Y + G+C+
Sbjct: 421 SFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACI- 479
Query: 399 RDASGVLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAPLIT 458
VL D G G L T++ S + +I
Sbjct: 480 --EGVVLRDKY--GDGVSRNLVVG-----------------------TLAWPSPW--VIV 510
Query: 459 AGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAVA 518
G F +T + L L A ++ Q + +D + P + FG G N EP LL IA
Sbjct: 511 IGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGK-VNGEPTWALLLTALIAEL 569
Query: 519 FIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIISV 578
I+IA L+ +API+S FFL Y +N +C ++ +P WRP F+YY+ + G + +
Sbjct: 570 GILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCL 629
Query: 579 VIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDHI 638
+MF+ +W+ AL+A+ + + Y+ Y+ E WG ++ S + A + L E H
Sbjct: 630 ALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHT 689
Query: 639 KNYRPQCLVLTGPPN----FRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPELQLIAN 694
KN+RPQ LVL P L+ F L I G V+ G + E Q
Sbjct: 690 KNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQ 749
Query: 695 GHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNW-QSAHPAT 753
+ K+K F V+A +R G+ L+Q+ GLG M+ N +V+G+ W QS P
Sbjct: 750 TIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRA 809
Query: 754 VEDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAHINPVFDPAEDGKEASARGARPSVS 813
+ +I + C L V K N F P+ +
Sbjct: 810 WKTFIDTVR---------CTTAAHLALLVPK------NIAFYPSNHERYLEGH------- 847
Query: 814 GALDPKALVKEEQATTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRVF 873
ID++W+ DGG+ +L+P+LL + + W KC++R+F
Sbjct: 848 --------------------------IDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIF 881
Query: 874 VGGQI-NRMDQERKAIISLLSKFRLGFHEVHILP-------------------------- 906
Q+ + Q +K + L RL EV ++
Sbjct: 882 TVAQMDDNSIQMKKDLAVFLYHLRLE-AEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQ 940
Query: 907 -DINQNPRAEHTKRFEDMIAPFRLNDGF---KDEATVNEMRRDCPWKISDEEITK----- 957
+ + R + +D + RL + +DE+ V + W D+ +T+
Sbjct: 941 MRLTKTEREREAQLVKDRHSALRLESLYSDEEDESAVGADKIQMTW-TRDKYMTETWDPS 999
Query: 958 -----------------NRVKSLRQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYM 1000
N + V+LNE+++ S DA L+++ +P + YM
Sbjct: 1000 HAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYM 1059
Query: 1001 AWLETLSQDLRPPVILIRGNQENVLTFY 1028
+LE L++ L V+L+RG V+T Y
Sbjct: 1060 EFLEVLTEGLE-RVLLVRGGGREVITIY 1086
Score = 125 bits (315), Expect = 2e-28
Identities = 69/198 (34%), Positives = 111/198 (56%), Gaps = 17/198 (8%)
Query: 119 EGEAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLS 178
E E+G + + E G + GV + C+ NI+GVIL+LRL W+ AG++ +I+L+
Sbjct: 103 EAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLIC 162
Query: 179 VTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGF 238
T +T +S+SAI+TNG V +GG+YF+ISRSLGPE GG++GL F AM+ +G
Sbjct: 163 CCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGA 222
Query: 239 AETVRDLLQEYGAP---IVDP----------INDIRIIGVVSVTVLLAISLAGMEWESKA 285
E +L Y AP I P +N++R+ G + +T + + G+++ +K
Sbjct: 223 IE----ILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKF 278
Query: 286 QVLFFLVIMVSFANYLVG 303
LF +++S + G
Sbjct: 279 ASLFLACVIISILSIYAG 296
>gi|4827006 solute carrier family 12, member 4 isoform a [Homo
sapiens]
Length = 1085
Score = 231 bits (588), Expect = 3e-60
Identities = 195/748 (26%), Positives = 314/748 (41%), Gaps = 140/748 (18%)
Query: 339 TFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSCVV 398
+F + IFFPS TGI+AG+N SGDL+D +IP GT++AI T++ Y + G+C+
Sbjct: 419 SFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACI- 477
Query: 399 RDASGVLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAPLIT 458
VL D G G L T++ S + +I
Sbjct: 478 --EGVVLRDKY--GDGVSRNLVVG-----------------------TLAWPSPW--VIV 508
Query: 459 AGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAVA 518
G F +T + L L A ++ Q + +D + P + FG G N EP LL IA
Sbjct: 509 IGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGK-VNGEPTWALLLTALIAEL 567
Query: 519 FIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIISV 578
I+IA L+ +API+S FFL Y +N +C ++ +P WRP F+YY+ + G + +
Sbjct: 568 GILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCL 627
Query: 579 VIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDHI 638
+MF+ +W+ AL+A+ + + Y+ Y+ E WG ++ S + A + L E H
Sbjct: 628 ALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHT 687
Query: 639 KNYRPQCLVLTGPPN----FRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPELQLIAN 694
KN+RPQ LVL P L+ F L I G V+ G + E Q
Sbjct: 688 KNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQ 747
Query: 695 GHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNW-QSAHPAT 753
+ K+K F V+A +R G+ L+Q+ GLG M+ N +V+G+ W QS P
Sbjct: 748 TIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRA 807
Query: 754 VEDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAHINPVFDPAEDGKEASARGARPSVS 813
+ +I + C L V K N F P+ +
Sbjct: 808 WKTFIDTVR---------CTTAAHLALLVPK------NIAFYPSNHERYLEGH------- 845
Query: 814 GALDPKALVKEEQATTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRVF 873
ID++W+ DGG+ +L+P+LL + + W KC++R+F
Sbjct: 846 --------------------------IDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIF 879
Query: 874 VGGQI-NRMDQERKAIISLLSKFRLGFHEVHILP-------------------------- 906
Q+ + Q +K + L RL EV ++
Sbjct: 880 TVAQMDDNSIQMKKDLAVFLYHLRLE-AEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQ 938
Query: 907 -DINQNPRAEHTKRFEDMIAPFRLNDGF---KDEATVNEMRRDCPWKISDEEITK----- 957
+ + R + +D + RL + +DE+ V + W D+ +T+
Sbjct: 939 MRLTKTEREREAQLVKDRHSALRLESLYSDEEDESAVGADKIQMTW-TRDKYMTETWDPS 997
Query: 958 -----------------NRVKSLRQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYM 1000
N + V+LNE+++ S DA L+++ +P + YM
Sbjct: 998 HAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYM 1057
Query: 1001 AWLETLSQDLRPPVILIRGNQENVLTFY 1028
+LE L++ L V+L+RG V+T Y
Sbjct: 1058 EFLEVLTEGLE-RVLLVRGGGREVITIY 1084
Score = 125 bits (315), Expect = 2e-28
Identities = 69/198 (34%), Positives = 111/198 (56%), Gaps = 17/198 (8%)
Query: 119 EGEAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLS 178
E E+G + + E G + GV + C+ NI+GVIL+LRL W+ AG++ +I+L+
Sbjct: 101 EAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLIC 160
Query: 179 VTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGF 238
T +T +S+SAI+TNG V +GG+YF+ISRSLGPE GG++GL F AM+ +G
Sbjct: 161 CCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGA 220
Query: 239 AETVRDLLQEYGAP---IVDP----------INDIRIIGVVSVTVLLAISLAGMEWESKA 285
E +L Y AP I P +N++R+ G + +T + + G+++ +K
Sbjct: 221 IE----ILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKF 276
Query: 286 QVLFFLVIMVSFANYLVG 303
LF +++S + G
Sbjct: 277 ASLFLACVIISILSIYAG 294
>gi|38569457 solute carrier family 12, member 8 [Homo sapiens]
Length = 714
Score = 224 bits (572), Expect = 2e-58
Identities = 129/421 (30%), Positives = 217/421 (51%), Gaps = 48/421 (11%)
Query: 132 EPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLSVTVTSITGLSISA 191
EPV FG GV CM+NI+GV+L+LR W+ G++L ++ + V +T LS
Sbjct: 35 EPVLFGTWDGVFTSCMINIFGVVLFLRTGWLVGNTGVLLGMFLVSFVILVALVTVLSGIG 94
Query: 192 ISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAETVRDLLQEYGA 251
+ + SGG Y +IS LG + GG+IGL++ F V AM+ GFAE++ DLL
Sbjct: 95 VGERSSIGSGGVYSMISSVLGGQTGGTIGLLYVFGQCVAGAMYITGFAESISDLLG---- 150
Query: 252 PIVDPINDIRIIGVVSVTVLLAISLAGMEWESKAQVLFFLVIMVSFANYLVGTLIPPSED 311
+ I +R I V + LL I+LAG++W + Q+L ++ VS +++VG+ +
Sbjct: 151 --LGNIWAVRGISVAVLLALLGINLAGVKWIIRLQLLLLFLLAVSTLDFVVGSF---THL 205
Query: 312 KASKGFFSYRADIFVQNLVPDWRGPDGTFFGMFSIFFPSATGILAGANISGDLKDPAIAI 371
GF Y ++ N +PD+ P +FF +F +FFP+ATG++AG N+ GDL++PA +I
Sbjct: 206 DPEHGFIGYSPELLQNNTLPDY-SPGESFFTVFGVFFPAATGVMAGFNMGGDLREPAASI 264
Query: 372 PKGTLMAIFWTTISYLAISATIGSCVVRDASGVLNDTVTPGWGACEGLACSYGWNFTECT 431
P G+L A+ + Y+ +G+ R+ A Y + E
Sbjct: 265 PLGSLAAVGISWFLYIVFVFLLGAICTRE-------------------ALRYDFLIAE-- 303
Query: 432 QQHSCHYGLINYYQTMSMVSGFAPLITAGIFGATLSSALACLVSAAKVFQCLCEDQLYPL 491
VS L G++ ++L+S + L A ++ QC+ ++++ P
Sbjct: 304 -----------------KVSLMGFLFLLGLYISSLASCMGGLYGAPRILQCIAQEKVIPA 346
Query: 492 IGFFGKGYGKNKEPVRGYLLAYAIAVAFIIIAELNTIAPIISNFFLCSYALINFSCFHAS 551
+ G+G G NK PV L + +AF+ + ++N +API++ F+ +Y +++S F S
Sbjct: 347 LACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVAVDYSYFSLS 406
Query: 552 I 552
+
Sbjct: 407 M 407
Score = 44.7 bits (104), Expect = 5e-04
Identities = 21/62 (33%), Positives = 35/62 (56%), Gaps = 4/62 (6%)
Query: 558 WRPSFQYY----NKWAALFGAIISVVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWG 613
WR S +Y N W +L GA+ S++IMF++ W L+ +GV + Y+ P ++ G
Sbjct: 582 WRRSTSFYTHMCNPWVSLLGAVGSLLIMFVIQWVYTLVNMGVAAIVYFYIGRASPGLHLG 641
Query: 614 SS 615
S+
Sbjct: 642 SA 643
>gi|198041678 solute carrier family 12 (potassium-chloride
transporter), member 5 isoform 1 [Homo sapiens]
Length = 1139
Score = 222 bits (565), Expect = 2e-57
Identities = 160/566 (28%), Positives = 254/566 (44%), Gaps = 95/566 (16%)
Query: 343 MFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSC----VV 398
+ I+FPS TGI+AG+N SGDL+D +IP GT++AI T+ Y++ G+C V+
Sbjct: 426 LVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVL 485
Query: 399 RDASG-VLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAPLI 457
RD G +N + G LA W +I
Sbjct: 486 RDKFGEAVNGNLVVGT-----LAWPSPW------------------------------VI 510
Query: 458 TAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAV 517
G F +T + L L A ++ Q + D + P + FG G N EP LL I
Sbjct: 511 VIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKA-NGEPTWALLLTACICE 569
Query: 518 AFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIIS 577
I+IA L+ +API+S FFL Y +N +C ++ +P WRP F+YY+ + G +
Sbjct: 570 IGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLC 629
Query: 578 VVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDH 637
+ +MF+ +W+ AL+A+ + + Y+ Y+ E WG ++ S + A + L E H
Sbjct: 630 LALMFICSWYYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPH 689
Query: 638 IKNYRPQCLVLTGPPN----FRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPELQLIA 693
KN+RPQ LVL P L+ L I G VL G + P+ Q
Sbjct: 690 TKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQAQRAE 749
Query: 694 NGHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNW-QSAHPA 752
+ + K+K F VI+ +LR GV L+Q+ GLG ++ N ++VG+ +NW Q
Sbjct: 750 ESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQ 809
Query: 753 TVEDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAHINPVFDPAEDGKEASARGARPSV 812
T ++I ++ + + + V + NVS NP E + G
Sbjct: 810 TWRNFIELVRETTAGHLALLVTK-----NVSMFPG---NP---------ERFSEG----- 847
Query: 813 SGALDPKALVKEEQATTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRV 872
+ID++W+ DGG+ +L+P+LL + W KCK+R+
Sbjct: 848 --------------------------SIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRI 881
Query: 873 FVGGQI-NRMDQERKAIISLLSKFRL 897
F Q+ + Q +K + + L R+
Sbjct: 882 FTVAQMDDNSIQMKKDLTTFLYHLRI 907
Score = 120 bits (302), Expect = 5e-27
Identities = 65/204 (31%), Positives = 111/204 (54%), Gaps = 13/204 (6%)
Query: 119 EGEAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLS 178
E E +K P + R G GV + C+ NI+GVIL+LRL W+ AGI+ ++ ++ +
Sbjct: 103 EAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFIC 162
Query: 179 VTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGF 238
+ T +T +S+SAI+TNG V +GG+Y++ISRSLGPE GG++GL F AM+ +G
Sbjct: 163 CSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGT 222
Query: 239 AETVRDLL---------QEYGAPIVDPINDIRIIGVVSVTVLLAISLAGMEWESKAQVLF 289
E + L ++ +N++R+ G +T + + G+++ +K ++F
Sbjct: 223 IEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVF 282
Query: 290 ----FLVIMVSFANYLVGTLIPPS 309
L I+ +A + PP+
Sbjct: 283 LGCVILSILAIYAGVIKSAFDPPN 306
Score = 47.4 bits (111), Expect = 7e-05
Identities = 26/77 (33%), Positives = 46/77 (59%), Gaps = 2/77 (2%)
Query: 953 EEITKNRVKSLRQ-VRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLETLSQDLR 1011
E + ++ V+ + VRLNE+++ SRDA L+++ +P + + YM +LE L++ L
Sbjct: 1063 ENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEHL- 1121
Query: 1012 PPVILIRGNQENVLTFY 1028
V+L+RG V+T Y
Sbjct: 1122 DRVMLVRGGGREVITIY 1138
>gi|11968148 solute carrier family 12 (potassium-chloride
transporter), member 5 isoform 2 [Homo sapiens]
Length = 1116
Score = 222 bits (565), Expect = 2e-57
Identities = 160/566 (28%), Positives = 254/566 (44%), Gaps = 95/566 (16%)
Query: 343 MFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSC----VV 398
+ I+FPS TGI+AG+N SGDL+D +IP GT++AI T+ Y++ G+C V+
Sbjct: 403 LVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVL 462
Query: 399 RDASG-VLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAPLI 457
RD G +N + G LA W +I
Sbjct: 463 RDKFGEAVNGNLVVGT-----LAWPSPW------------------------------VI 487
Query: 458 TAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAV 517
G F +T + L L A ++ Q + D + P + FG G N EP LL I
Sbjct: 488 VIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKA-NGEPTWALLLTACICE 546
Query: 518 AFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIIS 577
I+IA L+ +API+S FFL Y +N +C ++ +P WRP F+YY+ + G +
Sbjct: 547 IGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLC 606
Query: 578 VVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDH 637
+ +MF+ +W+ AL+A+ + + Y+ Y+ E WG ++ S + A + L E H
Sbjct: 607 LALMFICSWYYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPH 666
Query: 638 IKNYRPQCLVLTGPPN----FRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPELQLIA 693
KN+RPQ LVL P L+ L I G VL G + P+ Q
Sbjct: 667 TKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQAQRAE 726
Query: 694 NGHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNW-QSAHPA 752
+ + K+K F VI+ +LR GV L+Q+ GLG ++ N ++VG+ +NW Q
Sbjct: 727 ESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQ 786
Query: 753 TVEDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAHINPVFDPAEDGKEASARGARPSV 812
T ++I ++ + + + V + NVS NP E + G
Sbjct: 787 TWRNFIELVRETTAGHLALLVTK-----NVSMFPG---NP---------ERFSEG----- 824
Query: 813 SGALDPKALVKEEQATTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRV 872
+ID++W+ DGG+ +L+P+LL + W KCK+R+
Sbjct: 825 --------------------------SIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRI 858
Query: 873 FVGGQI-NRMDQERKAIISLLSKFRL 897
F Q+ + Q +K + + L R+
Sbjct: 859 FTVAQMDDNSIQMKKDLTTFLYHLRI 884
Score = 120 bits (302), Expect = 5e-27
Identities = 65/204 (31%), Positives = 111/204 (54%), Gaps = 13/204 (6%)
Query: 119 EGEAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLS 178
E E +K P + R G GV + C+ NI+GVIL+LRL W+ AGI+ ++ ++ +
Sbjct: 80 EAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFIC 139
Query: 179 VTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGF 238
+ T +T +S+SAI+TNG V +GG+Y++ISRSLGPE GG++GL F AM+ +G
Sbjct: 140 CSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGT 199
Query: 239 AETVRDLL---------QEYGAPIVDPINDIRIIGVVSVTVLLAISLAGMEWESKAQVLF 289
E + L ++ +N++R+ G +T + + G+++ +K ++F
Sbjct: 200 IEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVF 259
Query: 290 ----FLVIMVSFANYLVGTLIPPS 309
L I+ +A + PP+
Sbjct: 260 LGCVILSILAIYAGVIKSAFDPPN 283
Score = 47.4 bits (111), Expect = 7e-05
Identities = 26/77 (33%), Positives = 46/77 (59%), Gaps = 2/77 (2%)
Query: 953 EEITKNRVKSLRQ-VRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLETLSQDLR 1011
E + ++ V+ + VRLNE+++ SRDA L+++ +P + + YM +LE L++ L
Sbjct: 1040 ENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEHL- 1098
Query: 1012 PPVILIRGNQENVLTFY 1028
V+L+RG V+T Y
Sbjct: 1099 DRVMLVRGGGREVITIY 1115
>gi|55743077 ATPase, class I, type 8B, member 2 isoform b [Homo
sapiens]
Length = 387
Score = 35.8 bits (81), Expect = 0.21
Identities = 30/116 (25%), Positives = 55/116 (47%), Gaps = 9/116 (7%)
Query: 525 LNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIISVVIMFLL 584
+NT+ I F +C ++ +A + G R FQ Y W A+ S L
Sbjct: 273 MNTLVLWIFGFLVCMGVILAIG--NAIWEHEVGMR--FQVYLPWDE---AVDSAFFSGFL 325
Query: 585 TWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDHIKN 640
++W+ +I + V+ + LYV Y P + WG S ++G + L +S+ + + + K+
Sbjct: 326 SFWSYIIILNTVVPISLYVRY-VPSLTWGLSRESGG-PIELFFSMKMKSLRSNEKS 379
>gi|134304858 solute carrier family 7, member 2 isoform 2 [Homo
sapiens]
Length = 658
Score = 34.7 bits (78), Expect = 0.48
Identities = 62/287 (21%), Positives = 106/287 (36%), Gaps = 57/287 (19%)
Query: 261 RIIGVVSVTVLLAISLAGMEWESKAQVLFFLVIMVSFANYLVGTLIPPSEDKAS----KG 316
++ V++ VLL + +AG K V + + N PPSE+ S G
Sbjct: 192 KVFTAVNILVLLFVMVAGFV---KGNVANWKISEEFLKNISASAREPPSENGTSIYGAGG 248
Query: 317 FFSYRADIFVQNLVPDWRGPDGTFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTL 376
F Y G GT G + F+ + G A ++++P AIP G +
Sbjct: 249 FMPY--------------GFTGTLAGAATCFY-AFVGFDCIATTGEEVRNPQKAIPIGIV 293
Query: 377 MAIFWTTISYLAISATIGSCVVRDASGVLNDTVTPGWGACEGLACSYGWNFTECTQQHSC 436
++ ++Y +SA + + L D +P A E + GW
Sbjct: 294 TSLLVCFMAYFGVSAALTLMM----PYYLLDEKSPLPVAFEYV----GW----------- 334
Query: 437 HYGLINYYQTMSMVSGFAPLITAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFG 496
G Y ++ AG A +S L + +V + ED L L
Sbjct: 335 --GPAKY------------VVAAGSLCALSTSLLGSIFPMPRVIYAMAEDGL--LFKCLA 378
Query: 497 KGYGKNKEPVRGYLLAYAIAVAFIIIAELNTIAPIISNFFLCSYALI 543
+ K K P+ L + A+A + +L + ++S L +Y+L+
Sbjct: 379 QINSKTKTPIIATLSSGAVAALMAFLFDLKALVDMMSIGTLMAYSLV 425
>gi|7657683 solute carrier family 7, (cationic amino acid
transporter, y+ system) member 11 [Homo sapiens]
Length = 501
Score = 32.7 bits (73), Expect = 1.8
Identities = 44/219 (20%), Positives = 89/219 (40%), Gaps = 22/219 (10%)
Query: 177 LSVTVTSITG-------LSISAISTNGKVKSGGTYFLISRSLGP-ELGGSIGLIFAFANA 228
+S+T+ ++ G LS + + T K KSGG Y I GP + +
Sbjct: 78 MSLTIWTVCGVLSLFGALSYAELGTTIK-KSGGHYTYILEVFGPLPAFVRVWVELLIIRP 136
Query: 229 VGVAMHTVGFAETVRDLLQEYGAPIVDPINDIRIIGVVSVTVLLAISLAGMEWESKAQVL 288
A+ ++ F R +L+ + P I++I V +TV++ ++ + W ++ Q+
Sbjct: 137 AATAVISLAFG---RYILEPFFIQCEIPELAIKLITAVGITVVMVLNSMSVSWSARIQIF 193
Query: 289 FFLVIMVSFANYLVGTLIPPSEDKASKGFFSYRADIFVQNLVPDWRGPDGTFFGMFSIFF 348
+ + + +I P + KG D F R P ++GM++
Sbjct: 194 LTFCKLTA-----ILIIIVPGVMQLIKGQTQNFKDAFSGRDSSITRLPLAFYYGMYAY-- 246
Query: 349 PSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYL 387
G ++ ++++P IP +++ TI Y+
Sbjct: 247 ---AGWFYLNFVTEEVENPEKTIPLAICISMAIVTIGYV 282
>gi|239740773 PREDICTED: similar to diffuse panbronchiolitis critical
region 1 [Homo sapiens]
Length = 1400
Score = 32.3 bits (72), Expect = 2.4
Identities = 20/66 (30%), Positives = 35/66 (53%), Gaps = 1/66 (1%)
Query: 2 AELPTTETPGDATLC-SGRFTISTLLSSDEPSPPAAYDSSHPSHLTHSSTFCMRTFGYNT 60
+E+PT T AT S + + +T+ S+ +PP +++ S T +ST G++T
Sbjct: 1189 SEIPTASTTDSATTAISTKASGTTVESAPSTAPPTPAETTTASVPTTTSTTGSENTGHHT 1248
Query: 61 IDVVPT 66
+ VPT
Sbjct: 1249 VSSVPT 1254
>gi|6005715 solute carrier family 6 (amino acid transporter), member
14 [Homo sapiens]
Length = 642
Score = 32.0 bits (71), Expect = 3.1
Identities = 21/62 (33%), Positives = 29/62 (46%), Gaps = 10/62 (16%)
Query: 544 NFSCFHASITNSPGWRPSFQYYNKWAAL-------FGAIISVVIMFLLTWWAALIAIGVV 596
NF+C + S PG PS QY+NK A G I+ + + LL W + +G
Sbjct: 197 NFTCINGSEIYQPGQLPSEQYWNKVALQRSSGMNETGVIVWYLALCLLLAW---LIVGAA 253
Query: 597 LF 598
LF
Sbjct: 254 LF 255
>gi|109948288 solute carrier family 7, member 2 isoform 1 [Homo
sapiens]
Length = 697
Score = 31.6 bits (70), Expect = 4.0
Identities = 61/287 (21%), Positives = 105/287 (36%), Gaps = 58/287 (20%)
Query: 261 RIIGVVSVTVLLAISLAGMEWESKAQVLFFLVIMVSFANYLVGTLIPPSEDKAS----KG 316
++ V++ VLL + +AG K V + + N PPSE+ S G
Sbjct: 232 KVFTAVNILVLLFVMVAGFV---KGNVANWKISEEFLKNISASAREPPSENGTSIYGAGG 288
Query: 317 FFSYRADIFVQNLVPDWRGPDGTFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTL 376
F Y G GT G + F+ + G A ++++P AIP G +
Sbjct: 289 FMPY--------------GFTGTLAGAATCFY-AFVGFDCIATTGEEVRNPQKAIPIGIV 333
Query: 377 MAIFWTTISYLAISATIGSCVVRDASGVLNDTVTPGWGACEGLACSYGWNFTECTQQHSC 436
++ ++Y +SA + + L D +P A E + GW
Sbjct: 334 TSLLVCFMAYFGVSAALTLMM----PYYLLDEKSPLPVAFEYV----GW----------- 374
Query: 437 HYGLINYYQTMSMVSGFAPLITAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFG 496
G Y ++ AG A +S L + ++ + D L L F
Sbjct: 375 --GPAKY------------VVAAGSLCALSTSLLGSMFPLPRILFAMARDGL--LFRFLA 418
Query: 497 KGYGKNKEPVRGYLLAYAIAVAFIIIAELNTIAPIISNFFLCSYALI 543
+ K + PV L A I+ + +L + ++S L +Y+L+
Sbjct: 419 R-VSKRQSPVAATLTAGVISALMAFLFDLKALVDMMSIGTLMAYSLV 464
>gi|153792564 solute carrier family 47, member 2 isoform 2 [Homo
sapiens]
Length = 566
Score = 30.8 bits (68), Expect = 6.9
Identities = 24/92 (26%), Positives = 35/92 (38%), Gaps = 4/92 (4%)
Query: 513 YAIAVAFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALF 572
YA+ + + A IIS F + L+ + GW S Q W F
Sbjct: 199 YALVSVLNLGVRGSAYANIISQFAQTVFLLLYIVLKKLHLETWAGW--SSQCLQDWGPFF 256
Query: 573 GAIISVVIMFLLTWWAALIAIGVVLFLLLYVI 604
+ ++M + WWA IG L LL V+
Sbjct: 257 SLAVPSMLMICVEWWA--YEIGSFLMGLLSVV 286
>gi|38261960 solute carrier family 47, member 2 isoform 1 [Homo
sapiens]
Length = 602
Score = 30.8 bits (68), Expect = 6.9
Identities = 24/92 (26%), Positives = 35/92 (38%), Gaps = 4/92 (4%)
Query: 513 YAIAVAFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALF 572
YA+ + + A IIS F + L+ + GW S Q W F
Sbjct: 235 YALVSVLNLGVRGSAYANIISQFAQTVFLLLYIVLKKLHLETWAGW--SSQCLQDWGPFF 292
Query: 573 GAIISVVIMFLLTWWAALIAIGVVLFLLLYVI 604
+ ++M + WWA IG L LL V+
Sbjct: 293 SLAVPSMLMICVEWWA--YEIGSFLMGLLSVV 322
>gi|203098995 solute carrier family 2 (facilitated glucose
transporter), member 13 [Homo sapiens]
Length = 648
Score = 30.4 bits (67), Expect = 9.0
Identities = 22/88 (25%), Positives = 35/88 (39%), Gaps = 7/88 (7%)
Query: 381 WTTISYLAISATIGSCVVRDASGVLNDTVTPGWGACEGLACSYGWNF-----TECTQQHS 435
WT + L + + + +N + P W G ACS G N+ T H+
Sbjct: 507 WTALLGLILYLVFFAPGMGPMPWTVNSEIYPLWARSTGNACSSGINWIFNVLVSLTFLHT 566
Query: 436 CHYGLINYYQTMSMVSGFAPLITAGIFG 463
Y + YY + +GFA + I+G
Sbjct: 567 AEY--LTYYGAFFLYAGFAAVGLLFIYG 592
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.138 0.428
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,652,666
Number of Sequences: 37866
Number of extensions: 1673431
Number of successful extensions: 3738
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 21
Number of HSP's successfully gapped in prelim test: 10
Number of HSP's that attempted gapping in prelim test: 3604
Number of HSP's gapped (non-prelim): 114
length of query: 1030
length of database: 18,247,518
effective HSP length: 112
effective length of query: 918
effective length of database: 14,006,526
effective search space: 12857990868
effective search space used: 12857990868
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.