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Search of human proteins with 18677733
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|18677733 copine IV [Homo sapiens]
(557 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|18677733 copine IV [Homo sapiens] 1136 0.0
gi|25141328 copine 7 isoform a [Homo sapiens] 783 0.0
gi|5174421 copine 6 [Homo sapiens] 702 0.0
gi|7656993 copine 7 isoform b [Homo sapiens] 657 0.0
gi|4503015 copine III [Homo sapiens] 603 e-172
gi|30181236 copine II [Homo sapiens] 580 e-166
gi|23397708 copine I isoform a [Homo sapiens] 547 e-155
gi|23397706 copine I isoform a [Homo sapiens] 547 e-155
gi|23397704 copine I isoform a [Homo sapiens] 547 e-155
gi|23397702 copine I isoform a [Homo sapiens] 547 e-155
gi|23397700 copine I isoform a [Homo sapiens] 547 e-155
gi|23397698 copine I isoform a [Homo sapiens] 547 e-155
gi|23397696 copine I isoform a [Homo sapiens] 547 e-155
gi|197333761 copine I isoform b [Homo sapiens] 547 e-155
gi|25121972 copine VIII [Homo sapiens] 525 e-149
gi|25141323 copine V [Homo sapiens] 515 e-146
gi|88703066 copine-like protein [Homo sapiens] 497 e-140
gi|13384594 protein kinase C, gamma [Homo sapiens] 53 8e-07
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] 51 3e-06
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens] 51 3e-06
gi|4506067 protein kinase C, alpha [Homo sapiens] 48 2e-05
gi|28376627 synaptotagmin IX [Homo sapiens] 47 6e-05
gi|150170670 piccolo isoform 2 [Homo sapiens] 46 1e-04
gi|150378539 piccolo isoform 1 [Homo sapiens] 46 1e-04
gi|39752671 synaptotagmin X [Homo sapiens] 40 0.006
gi|6005997 double C2-like domains, beta [Homo sapiens] 39 0.010
gi|45504376 synaptotagmin VI [Homo sapiens] 39 0.013
gi|238550198 synaptotagmin III [Homo sapiens] 39 0.016
gi|238550196 synaptotagmin III [Homo sapiens] 39 0.016
gi|14150054 synaptotagmin III [Homo sapiens] 39 0.016
>gi|18677733 copine IV [Homo sapiens]
Length = 557
Score = 1136 bits (2939), Expect = 0.0
Identities = 557/557 (100%), Positives = 557/557 (100%)
Query: 1 MKKMSNIYESAANTLGIFNSPCLTKVELRVACKGISDRDALSKPDPCVILKMQSHGQWFE 60
MKKMSNIYESAANTLGIFNSPCLTKVELRVACKGISDRDALSKPDPCVILKMQSHGQWFE
Sbjct: 1 MKKMSNIYESAANTLGIFNSPCLTKVELRVACKGISDRDALSKPDPCVILKMQSHGQWFE 60
Query: 61 VDRTEVIRTCINPVYSKLFTVDFYFEEVQRLRFEVHDISSNHNGLKEADFLGGMECTLGQ 120
VDRTEVIRTCINPVYSKLFTVDFYFEEVQRLRFEVHDISSNHNGLKEADFLGGMECTLGQ
Sbjct: 61 VDRTEVIRTCINPVYSKLFTVDFYFEEVQRLRFEVHDISSNHNGLKEADFLGGMECTLGQ 120
Query: 121 IVSQRKLSKSLLKHGNTAGKSSITVIAEELSGNDDYVELAFNARKLDDKDFFSKSDPFLE 180
IVSQRKLSKSLLKHGNTAGKSSITVIAEELSGNDDYVELAFNARKLDDKDFFSKSDPFLE
Sbjct: 121 IVSQRKLSKSLLKHGNTAGKSSITVIAEELSGNDDYVELAFNARKLDDKDFFSKSDPFLE 180
Query: 181 IFRMNDDATQQLVHRTEVVMNNLSPAWKSFKVSVNSLCSGDPDRRLKCIVWDWDSNGKHD 240
IFRMNDDATQQLVHRTEVVMNNLSPAWKSFKVSVNSLCSGDPDRRLKCIVWDWDSNGKHD
Sbjct: 181 IFRMNDDATQQLVHRTEVVMNNLSPAWKSFKVSVNSLCSGDPDRRLKCIVWDWDSNGKHD 240
Query: 241 FIGEFTSTFKEMRGAMEGKQVQWECINPKYKAKKKNYKNSGTVILNLCKIHKMHSFLDYI 300
FIGEFTSTFKEMRGAMEGKQVQWECINPKYKAKKKNYKNSGTVILNLCKIHKMHSFLDYI
Sbjct: 241 FIGEFTSTFKEMRGAMEGKQVQWECINPKYKAKKKNYKNSGTVILNLCKIHKMHSFLDYI 300
Query: 301 MGGCQIQFTVAIDFTASNGDPRNSCSLHYIHPYQPNEYLKALVAVGEICQDYDSDKMFPA 360
MGGCQIQFTVAIDFTASNGDPRNSCSLHYIHPYQPNEYLKALVAVGEICQDYDSDKMFPA
Sbjct: 301 MGGCQIQFTVAIDFTASNGDPRNSCSLHYIHPYQPNEYLKALVAVGEICQDYDSDKMFPA 360
Query: 361 FGFGARIPPEYTVSHDFAINFNEDNPECAGIQGVVEAYQSCLPKLQLYGPTNIAPIIQKV 420
FGFGARIPPEYTVSHDFAINFNEDNPECAGIQGVVEAYQSCLPKLQLYGPTNIAPIIQKV
Sbjct: 361 FGFGARIPPEYTVSHDFAINFNEDNPECAGIQGVVEAYQSCLPKLQLYGPTNIAPIIQKV 420
Query: 421 AKSASEETNTKEASQYFILLILTDGVITDMADTREAIVHASHLPMSVIIVGVGNADFSDM 480
AKSASEETNTKEASQYFILLILTDGVITDMADTREAIVHASHLPMSVIIVGVGNADFSDM
Sbjct: 421 AKSASEETNTKEASQYFILLILTDGVITDMADTREAIVHASHLPMSVIIVGVGNADFSDM 480
Query: 481 QMLDGDDGILRSPKGEPVLRDIVQFVPFRNFKHASPAALAKSVLAEVPNQVVDYYNGKGI 540
QMLDGDDGILRSPKGEPVLRDIVQFVPFRNFKHASPAALAKSVLAEVPNQVVDYYNGKGI
Sbjct: 481 QMLDGDDGILRSPKGEPVLRDIVQFVPFRNFKHASPAALAKSVLAEVPNQVVDYYNGKGI 540
Query: 541 KPKCSSEMYESSRTLAP 557
KPKCSSEMYESSRTLAP
Sbjct: 541 KPKCSSEMYESSRTLAP 557
>gi|25141328 copine 7 isoform a [Homo sapiens]
Length = 558
Score = 783 bits (2022), Expect = 0.0
Identities = 377/535 (70%), Positives = 456/535 (85%), Gaps = 2/535 (0%)
Query: 11 AANTLGIFNSPCLTKVELRVACKGISDRDALSKPDPCVILKMQSHGQWFEVDRTEVIRTC 70
AA T G +PC +KVELR++C+ + DRD L+K DP V L Q+ GQW +V RTEV+R+
Sbjct: 9 AAATPGGLPAPCASKVELRLSCRHLLDRDPLTKSDPSVALLQQAQGQWVQVGRTEVVRSS 68
Query: 71 INPVYSKLFTVDFYFEEVQRLRFEVHDISSNHN-GLKEADFLGGMECTLGQIVSQRKLSK 129
++PV+SK+FTVD+YFEEVQRLRFEV+D +E DFLGGMECTLGQIV+Q+K+++
Sbjct: 69 LHPVFSKVFTVDYYFEEVQRLRFEVYDTHGPSGFSCQEDDFLGGMECTLGQIVAQKKVTR 128
Query: 130 SLL-KHGNTAGKSSITVIAEELSGNDDYVELAFNARKLDDKDFFSKSDPFLEIFRMNDDA 188
LL K G AGKS+ITVIAE++SGN+ YVEL+F ARKLDDKD FSKSDPFLE++R+NDD
Sbjct: 129 PLLLKFGRNAGKSTITVIAEDISGNNGYVELSFRARKLDDKDLFSKSDPFLELYRVNDDQ 188
Query: 189 TQQLVHRTEVVMNNLSPAWKSFKVSVNSLCSGDPDRRLKCIVWDWDSNGKHDFIGEFTST 248
QLV+RTEVV NNL+P W++FKVS++SLCS + R LKC+VWD+DS GKHDFIGEF++T
Sbjct: 189 GLQLVYRTEVVKNNLNPVWEAFKVSLSSLCSCEETRPLKCLVWDYDSRGKHDFIGEFSTT 248
Query: 249 FKEMRGAMEGKQVQWECINPKYKAKKKNYKNSGTVILNLCKIHKMHSFLDYIMGGCQIQF 308
F+EM+ A E Q QW+C+NPKYK K+++YKNSG V+L K H+++SFLDYIMGGCQI F
Sbjct: 249 FEEMQKAFEEGQAQWDCVNPKYKQKRRSYKNSGVVVLADLKFHRVYSFLDYIMGGCQIHF 308
Query: 309 TVAIDFTASNGDPRNSCSLHYIHPYQPNEYLKALVAVGEICQDYDSDKMFPAFGFGARIP 368
TVAIDFTASNGDPRNSCSLHYI+PYQPNEYLKALV+VGEICQDYDSDK F A GFGARIP
Sbjct: 309 TVAIDFTASNGDPRNSCSLHYINPYQPNEYLKALVSVGEICQDYDSDKRFSALGFGARIP 368
Query: 369 PEYTVSHDFAINFNEDNPECAGIQGVVEAYQSCLPKLQLYGPTNIAPIIQKVAKSASEET 428
P+Y VSHDFAINFN ++ EC GIQGVVEAYQ+CLP++QLYGPTN+APII KVA+ A+ E
Sbjct: 369 PKYEVSHDFAINFNPEDDECEGIQGVVEAYQNCLPRVQLYGPTNVAPIISKVARVAAAEE 428
Query: 429 NTKEASQYFILLILTDGVITDMADTREAIVHASHLPMSVIIVGVGNADFSDMQMLDGDDG 488
+T +ASQY+ILLILTDGV+TDMADTREAIV AS LPMS+IIVGVGNADF+DMQ+LDGDDG
Sbjct: 429 STGKASQYYILLILTDGVVTDMADTREAIVRASRLPMSIIIVGVGNADFTDMQVLDGDDG 488
Query: 489 ILRSPKGEPVLRDIVQFVPFRNFKHASPAALAKSVLAEVPNQVVDYYNGKGIKPK 543
+LRSP+GEP LRDIVQFVPFR K+ASPAALAK VLAEVP QVV+YY+ +G+ P+
Sbjct: 489 VLRSPRGEPALRDIVQFVPFRELKNASPAALAKCVLAEVPKQVVEYYSHRGLPPR 543
>gi|5174421 copine 6 [Homo sapiens]
Length = 557
Score = 702 bits (1813), Expect = 0.0
Identities = 336/522 (64%), Positives = 426/522 (81%), Gaps = 3/522 (0%)
Query: 24 TKVELRVACKGISDRDALSKPDPCVILKMQSHGQWFEVDRTEVIRTCINPVYSKLFTVDF 83
++VELRV+C G+ DRD L+KP PCV+LK+ S QW EV+RTEV+R+C +PV+S++ +++
Sbjct: 20 SRVELRVSCHGLLDRDTLTKPHPCVLLKLYSDEQWVEVERTEVLRSCSSPVFSRVLALEY 79
Query: 84 YFEEVQRLRFEVHDISSNHNGLKEADFLGGMECTLGQIVSQRKLSKSLL-KHGNTAGKSS 142
+FEE Q L+F V D + FLG ECTLGQIVSQ K++K LL K+G TAGKS+
Sbjct: 80 FFEEKQPLQFHVFDAEDGATSPRNDTFLGSTECTLGQIVSQTKVTKPLLLKNGKTAGKST 139
Query: 143 ITVIAEELSGNDDYVELAFNARKLDDKDFFSKSDPFLEIFRMNDDATQQLVHRTEVVMNN 202
IT++AEE+SG +DYV+L F A KLD+KD FSKSDPF+EI++ N+D + QLV RTEVV NN
Sbjct: 140 ITIVAEEVSGTNDYVQLTFRAYKLDNKDLFSKSDPFMEIYKTNEDQSDQLVWRTEVVKNN 199
Query: 203 LSPAWKSFKVSVNSLCSGDPDRRLKCIVWDWDSNGKHDFIGEFTSTFKEMRG--AMEGKQ 260
L+P+W+ F++S++SLCS D R LK +V+D+DS+GKHDFIGEFTSTF+EM+ A G++
Sbjct: 200 LNPSWEPFRLSLHSLCSCDVHRPLKFLVYDYDSSGKHDFIGEFTSTFQEMQEGTANPGQE 259
Query: 261 VQWECINPKYKAKKKNYKNSGTVILNLCKIHKMHSFLDYIMGGCQIQFTVAIDFTASNGD 320
+QW+CINPKY+ KKKNYK+SGTV+L C + K+H+FLDYIMGGCQI FTVAIDFTASNGD
Sbjct: 260 MQWDCINPKYRDKKKNYKSSGTVVLAQCTVEKVHTFLDYIMGGCQISFTVAIDFTASNGD 319
Query: 321 PRNSCSLHYIHPYQPNEYLKALVAVGEICQDYDSDKMFPAFGFGARIPPEYTVSHDFAIN 380
PR+S SLH + P QPN YL+AL AVG ICQDYDSDK FPAFGFGARIPP + VSHDFAIN
Sbjct: 320 PRSSQSLHCLSPRQPNHYLQALRAVGGICQDYDSDKRFPAFGFGARIPPNFEVSHDFAIN 379
Query: 381 FNEDNPECAGIQGVVEAYQSCLPKLQLYGPTNIAPIIQKVAKSASEETNTKEASQYFILL 440
F+ +NPEC I GV+ +Y+ CLP++QLYGPTN+APII +VA+ A E +T +A++Y +LL
Sbjct: 380 FDPENPECEEISGVIASYRRCLPQIQLYGPTNVAPIINRVAEPAQREQSTGQATKYSVLL 439
Query: 441 ILTDGVITDMADTREAIVHASHLPMSVIIVGVGNADFSDMQMLDGDDGILRSPKGEPVLR 500
+LTDGV++DMA+TR AIV AS LPMS+IIVGVGNADFSDM++LDGDDG LR P+G P R
Sbjct: 440 VLTDGVVSDMAETRTAIVRASRLPMSIIIVGVGNADFSDMRLLDGDDGPLRCPRGVPAAR 499
Query: 501 DIVQFVPFRNFKHASPAALAKSVLAEVPNQVVDYYNGKGIKP 542
DIVQFVPFR+FK A+P+ALAK VLAEVP QVV+YY +GI P
Sbjct: 500 DIVQFVPFRDFKDAAPSALAKCVLAEVPRQVVEYYASQGISP 541
>gi|7656993 copine 7 isoform b [Homo sapiens]
Length = 633
Score = 657 bits (1694), Expect = 0.0
Identities = 313/425 (73%), Positives = 374/425 (88%), Gaps = 1/425 (0%)
Query: 120 QIVSQRKLSKSLL-KHGNTAGKSSITVIAEELSGNDDYVELAFNARKLDDKDFFSKSDPF 178
QIV+Q+K+++ LL K G AGKS+ITVIAE++SGN+ YVEL+F ARKLDDKD FSKSDPF
Sbjct: 194 QIVAQKKVTRPLLLKFGRNAGKSTITVIAEDISGNNGYVELSFRARKLDDKDLFSKSDPF 253
Query: 179 LEIFRMNDDATQQLVHRTEVVMNNLSPAWKSFKVSVNSLCSGDPDRRLKCIVWDWDSNGK 238
LE++R+NDD QLV+RTEVV NNL+P W++FKVS++SLCS + R LKC+VWD+DS GK
Sbjct: 254 LELYRVNDDQGLQLVYRTEVVKNNLNPVWEAFKVSLSSLCSCEETRPLKCLVWDYDSRGK 313
Query: 239 HDFIGEFTSTFKEMRGAMEGKQVQWECINPKYKAKKKNYKNSGTVILNLCKIHKMHSFLD 298
HDFIGEF++TF+EM+ A E Q QW+C+NPKYK K+++YKNSG V+L K H+++SFLD
Sbjct: 314 HDFIGEFSTTFEEMQKAFEEGQAQWDCVNPKYKQKRRSYKNSGVVVLADLKFHRVYSFLD 373
Query: 299 YIMGGCQIQFTVAIDFTASNGDPRNSCSLHYIHPYQPNEYLKALVAVGEICQDYDSDKMF 358
YIMGGCQI FTVAIDFTASNGDPRNSCSLHYI+PYQPNEYLKALV+VGEICQDYDSDK F
Sbjct: 374 YIMGGCQIHFTVAIDFTASNGDPRNSCSLHYINPYQPNEYLKALVSVGEICQDYDSDKRF 433
Query: 359 PAFGFGARIPPEYTVSHDFAINFNEDNPECAGIQGVVEAYQSCLPKLQLYGPTNIAPIIQ 418
A GFGARIPP+Y VSHDFAINFN ++ EC GIQGVVEAYQ+CLP++QLYGPTN+APII
Sbjct: 434 SALGFGARIPPKYEVSHDFAINFNPEDDECEGIQGVVEAYQNCLPRVQLYGPTNVAPIIS 493
Query: 419 KVAKSASEETNTKEASQYFILLILTDGVITDMADTREAIVHASHLPMSVIIVGVGNADFS 478
KVA+ A+ E +T +ASQY+ILLILTDGV+TDMADTREAIV AS LPMS+IIVGVGNADF+
Sbjct: 494 KVARVAAAEESTGKASQYYILLILTDGVVTDMADTREAIVRASRLPMSIIIVGVGNADFT 553
Query: 479 DMQMLDGDDGILRSPKGEPVLRDIVQFVPFRNFKHASPAALAKSVLAEVPNQVVDYYNGK 538
DMQ+LDGDDG+LRSP+GEP LRDIVQFVPFR K+ASPAALAK VLAEVP QVV+YY+ +
Sbjct: 554 DMQVLDGDDGVLRSPRGEPALRDIVQFVPFRELKNASPAALAKCVLAEVPKQVVEYYSHR 613
Query: 539 GIKPK 543
G+ P+
Sbjct: 614 GLPPR 618
Score = 132 bits (333), Expect = 6e-31
Identities = 65/111 (58%), Positives = 83/111 (74%), Gaps = 1/111 (0%)
Query: 11 AANTLGIFNSPCLTKVELRVACKGISDRDALSKPDPCVILKMQSHGQWFEVDRTEVIRTC 70
AA T G +PC +KVELR++C+ + DRD L+K DP V L Q+ GQW +V RTEV+R+
Sbjct: 9 AAATPGGLPAPCASKVELRLSCRHLLDRDPLTKSDPSVALLQQAQGQWVQVGRTEVVRSS 68
Query: 71 INPVYSKLFTVDFYFEEVQRLRFEVHDISSNHN-GLKEADFLGGMECTLGQ 120
++PV+SK+FTVD+YFEEVQRLRFEV+D +E DFLGGMECTLGQ
Sbjct: 69 LHPVFSKVFTVDYYFEEVQRLRFEVYDTHGPSGFSCQEDDFLGGMECTLGQ 119
Score = 35.4 bits (80), Expect = 0.14
Identities = 31/101 (30%), Positives = 48/101 (47%), Gaps = 10/101 (9%)
Query: 26 VELRVACKGISDRDALSKPDPCVILKMQSHGQWFE-VDRTEVIRTCINPVYSKLFTVDF- 83
VEL + + D+D SK DP + L + Q + V RTEV++ +NPV+ + F V
Sbjct: 232 VELSFRARKLDDKDLFSKSDPFLELYRVNDDQGLQLVYRTEVVKNNLNPVW-EAFKVSLS 290
Query: 84 ---YFEEVQRLRFEVHDISSNHNGLKEADFLGGMECTLGQI 121
EE + L+ V D S + DF+G T ++
Sbjct: 291 SLCSCEETRPLKCLVWDYDSR----GKHDFIGEFSTTFEEM 327
Score = 32.7 bits (73), Expect = 0.90
Identities = 20/51 (39%), Positives = 29/51 (56%), Gaps = 1/51 (1%)
Query: 157 VELAFNARKLDDKDFFSKSDPFLEIFRMNDDATQQLVHRTEVVMNNLSPAW 207
VEL + R L D+D +KSDP + + + Q V RTEVV ++L P +
Sbjct: 24 VELRLSCRHLLDRDPLTKSDPSVALLQQAQGQWVQ-VGRTEVVRSSLHPVF 73
>gi|4503015 copine III [Homo sapiens]
Length = 537
Score = 603 bits (1555), Expect = e-172
Identities = 297/523 (56%), Positives = 383/523 (73%), Gaps = 3/523 (0%)
Query: 22 CLTKVELRVACKGISDRDALSKPDPCVILKMQSHGQ-WFEVDRTEVIRTCINPVYSKLFT 80
C+TKV L V+C + D+D SK DP +L + + GQ W+EV+RTE I+ C+NP +SK F
Sbjct: 5 CVTKVALNVSCANLLDKDIGSKSDPLCVLFLNTSGQQWYEVERTERIKNCLNPQFSKTFI 64
Query: 81 VDFYFEEVQRLRFEVHDISSNHNGLKEADFLGGMECTLGQIVSQRKLSKSL-LKHGNTAG 139
+D+YFE VQ+L+F V+DI + L + DFLG ECTLGQIVS +KL++ L +K G AG
Sbjct: 65 IDYYFEVVQKLKFGVYDIDNKTIELSDDDFLGECECTLGQIVSSKKLTRPLVMKTGRPAG 124
Query: 140 KSSITVIAEELSGNDDYVELAFNARKLDDKDFFSKSDPFLEIFRMNDDATQQLVHRTEVV 199
K SIT+ AEE+ N V ARKLD+KD F KSDP+LE + D +VHRTEVV
Sbjct: 125 KGSITISAEEIKDNR-VVLFEMEARKLDNKDLFGKSDPYLEFHKQTSDGNWLMVHRTEVV 183
Query: 200 MNNLSPAWKSFKVSVNSLCSGDPDRRLKCIVWDWDSNGKHDFIGEFTSTFKEMRGAMEGK 259
NNL+P W+ FK+S+NSLC GD D+ +K +D+D++G HD IG F +T +++ A
Sbjct: 184 KNNLNPVWRPFKISLNSLCYGDMDKTIKVECYDYDNDGSHDLIGTFQTTMTKLKEASRSS 243
Query: 260 QVQWECINPKYKAKKKNYKNSGTVILNLCKIHKMHSFLDYIMGGCQIQFTVAIDFTASNG 319
V++ECIN K + KKK+YKNSG + + C+I +FLDYIMGGCQ+ FTV +DFT SNG
Sbjct: 244 PVEFECINEKKRQKKKSYKNSGVISVKQCEITVECTFLDYIMGGCQLNFTVGVDFTGSNG 303
Query: 320 DPRNSCSLHYIHPYQPNEYLKALVAVGEICQDYDSDKMFPAFGFGARIPPEYTVSHDFAI 379
DPR+ SLHYI P NEYL AL +VG + QDYD+DKMFPAFGFGA+IPP++ VSH+F +
Sbjct: 304 DPRSPDSLHYISPNGVNEYLTALWSVGLVIQDYDADKMFPAFGFGAQIPPQWQVSHEFPM 363
Query: 380 NFNEDNPECAGIQGVVEAYQSCLPKLQLYGPTNIAPIIQKVAKSASEETNTKEASQYFIL 439
NFN NP C GIQG+VEAY+SCLP+++LYGPTN +PII VA+ A+ T + ASQYF+L
Sbjct: 364 NFNPSNPYCNGIQGIVEAYRSCLPQIKLYGPTNFSPIINHVARFAAAATQQQTASQYFVL 423
Query: 440 LILTDGVITDMADTREAIVHASHLPMSVIIVGVGNADFSDMQMLDGDDGILRSPKGEPVL 499
LI+TDGVITD+ +TR+AIV+AS LPMS+IIVGVG ADFS M+ LDGD G LRSP GE +
Sbjct: 424 LIITDGVITDLDETRQAIVNASRLPMSIIIVGVGGADFSAMEFLDGDGGSLRSPLGEVAI 483
Query: 500 RDIVQFVPFRNFKHASPAALAKSVLAEVPNQVVDYYNGKGIKP 542
RDIVQFVPFR F++A ALA+ VLAE+P QVV Y+N + P
Sbjct: 484 RDIVQFVPFRQFQNAPKEALAQCVLAEIPQQVVGYFNTYKLLP 526
>gi|30181236 copine II [Homo sapiens]
Length = 548
Score = 580 bits (1496), Expect = e-166
Identities = 281/522 (53%), Positives = 376/522 (72%), Gaps = 2/522 (0%)
Query: 22 CLTKVELRVACKGISDRDALSKPDPCVILKMQSHGQWFEVDRTEVIRTCINPVYSKLFTV 81
C+ KVEL V+ + + DRD SK DP +L +++G+W E DRTE +NP +SK F +
Sbjct: 22 CVCKVELSVSGQNLLDRDVTSKSDPFCVLFTENNGRWIEYDRTETAINNLNPAFSKKFVL 81
Query: 82 DFYFEEVQRLRFEVHDISSNHNGLKEADFLGGMECTLGQIVSQRKLSKSLLK-HGNTAGK 140
D++FEEVQ+L+F + D + L E DFLG C+LG IVS +K+++ LL + AGK
Sbjct: 82 DYHFEEVQKLKFALFDQDKSSMRLDEHDFLGQFSCSLGTIVSSKKITRPLLLLNDKPAGK 141
Query: 141 SSITVIAEELSGNDDYVELAFNARKLDDKDFFSKSDPFLEIFRMNDDATQQLVHRTEVVM 200
IT+ A+ELS N + L+ R+LD KD F KSDPFLE ++ DD LVHRTEV+
Sbjct: 142 GLITIAAQELSDNR-VITLSLAGRRLDKKDLFGKSDPFLEFYKPGDDGKWMLVHRTEVIK 200
Query: 201 NNLSPAWKSFKVSVNSLCSGDPDRRLKCIVWDWDSNGKHDFIGEFTSTFKEMRGAMEGKQ 260
L P WK F V + SLC GD ++ ++ + +D+D++G HDFIGEF ++ +M A +
Sbjct: 201 YTLDPVWKPFTVPLVSLCDGDMEKPIQVMCYDYDNDGGHDFIGEFQTSVSQMCEARDSVP 260
Query: 261 VQWECINPKYKAKKKNYKNSGTVILNLCKIHKMHSFLDYIMGGCQIQFTVAIDFTASNGD 320
+++ECINPK + KKKNYKNSG +IL CKI++ +SFLDYI+GGCQ+ FTV IDFTASNG+
Sbjct: 261 LEFECINPKKQRKKKNYKNSGIIILRSCKINRDYSFLDYILGGCQLMFTVGIDFTASNGN 320
Query: 321 PRNSCSLHYIHPYQPNEYLKALVAVGEICQDYDSDKMFPAFGFGARIPPEYTVSHDFAIN 380
P + SLHYI+P NEYL A+ AVG+I QDYDSDKMFPA GFGA++PP++ VSH+FAIN
Sbjct: 321 PLDPSSLHYINPMGTNEYLSAIWAVGQIIQDYDSDKMFPALGFGAQLPPDWKVSHEFAIN 380
Query: 381 FNEDNPECAGIQGVVEAYQSCLPKLQLYGPTNIAPIIQKVAKSASEETNTKEASQYFILL 440
FN NP C+G+ G+ +AY +CLP ++ YGPTN +PI+ VA+ A++ T + A+QYFILL
Sbjct: 381 FNPTNPFCSGVDGIAQAYSACLPHIRFYGPTNFSPIVNHVARFAAQATQQRTATQYFILL 440
Query: 441 ILTDGVITDMADTREAIVHASHLPMSVIIVGVGNADFSDMQMLDGDDGILRSPKGEPVLR 500
I+TDGVI+DM +TR A+V AS LPMS+IIVGVGNADF+ M+ LDGD +LRS GE R
Sbjct: 441 IITDGVISDMEETRHAVVQASKLPMSIIIVGVGNADFAAMEFLDGDSRMLRSHTGEEAAR 500
Query: 501 DIVQFVPFRNFKHASPAALAKSVLAEVPNQVVDYYNGKGIKP 542
DIVQFVPFR F++A+ LAK+VLAE+P QVV Y+ K + P
Sbjct: 501 DIVQFVPFREFRNAAKETLAKAVLAELPQQVVQYFKHKNLPP 542
>gi|23397708 copine I isoform a [Homo sapiens]
Length = 537
Score = 547 bits (1409), Expect = e-155
Identities = 272/523 (52%), Positives = 366/523 (69%), Gaps = 8/523 (1%)
Query: 22 CLTKVELRVACKGISDRDALSKPDP-CVILKMQSHGQWFEVDRTEVIRTCINPVYSKLFT 80
C+T V+L ++C + D+D SK DP CV+L+ G W E+ RTE +R C +P +SK
Sbjct: 4 CVTLVQLSISCDHLIDKDIGSKSDPLCVLLQDVGGGSWAELGRTERVRNCSSPEFSKTLQ 63
Query: 81 VDFYFEEVQRLRFEVHDISSNHNGLKEADFLGGMECTLGQIVSQRKLSKSL-LKHGNTAG 139
+++ FE VQ+LRF ++DI + L++ DFLGG EC+LGQIVS + L+ L LK G AG
Sbjct: 64 LEYRFETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQVLTLPLMLKPGKPAG 123
Query: 140 KSSITVIAEELSGNDDYVELAFNARKLDDKDFFSKSDPFLEIFRMNDDATQQLVHRTEVV 199
+ +ITV A+EL N V + AR LD KDF KSDPFLE FR D LV+R+EV+
Sbjct: 124 RGTITVSAQELKDNR-VVTMEVEARNLDKKDFLGKSDPFLEFFRQGD-GKWHLVYRSEVI 181
Query: 200 MNNLSPAWKSFKVSVNSLCSGDPDRRLKCIVWDWDSNGKHDFIGEFTSTFKEMRGAMEGK 259
NNL+P WK F V V C G+P ++ D+DS+G HD IG F ++ +++
Sbjct: 182 KNNLNPTWKRFSVPVQHFCGGNPSTPIQVQCSDYDSDGSHDLIGTFHTSLAQLQAV---- 237
Query: 260 QVQWECINPKYKAKKKNYKNSGTVILNLCKIHKMHSFLDYIMGGCQIQFTVAIDFTASNG 319
++ECI+P+ + KKK+YKNSGT+ + +C++ +SFLDY+MGGCQI FTV +DFT SNG
Sbjct: 238 PAEFECIHPEKQQKKKSYKNSGTIRVKICRVETEYSFLDYVMGGCQINFTVGVDFTGSNG 297
Query: 320 DPRNSCSLHYIHPYQPNEYLKALVAVGEICQDYDSDKMFPAFGFGARIPPEYTVSHDFAI 379
DP + SLHY+ P NEYL AL +VG + QDYDSDK+FPAFGFGA++PP++ VSH+FA+
Sbjct: 298 DPSSPDSLHYLSPTGVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFAL 357
Query: 380 NFNEDNPECAGIQGVVEAYQSCLPKLQLYGPTNIAPIIQKVAKSASEETNTKEASQYFIL 439
NFN NP CAGIQG+V+AY+ LP+++LYGPTN APII VA+ A++ + ASQYF+L
Sbjct: 358 NFNPSNPYCAGIQGIVDAYRQALPQVRLYGPTNFAPIINHVARFAAQAAHQGTASQYFML 417
Query: 440 LILTDGVITDMADTREAIVHASHLPMSVIIVGVGNADFSDMQMLDGDDGILRSPKGEPVL 499
L+LTDG +TD+ TREA+V AS+LPMSVIIVGVG ADF M+ LD D G L + G+
Sbjct: 418 LLLTDGAVTDVEATREAVVRASNLPMSVIIVGVGGADFEAMEQLDADGGPLHTRSGQAAA 477
Query: 500 RDIVQFVPFRNFKHASPAALAKSVLAEVPNQVVDYYNGKGIKP 542
RDIVQFVP+R F++A ALA++VLAEVP Q+V Y+ +G P
Sbjct: 478 RDIVQFVPYRRFQNAPREALAQTVLAEVPTQLVSYFRAQGWAP 520
>gi|23397706 copine I isoform a [Homo sapiens]
Length = 537
Score = 547 bits (1409), Expect = e-155
Identities = 272/523 (52%), Positives = 366/523 (69%), Gaps = 8/523 (1%)
Query: 22 CLTKVELRVACKGISDRDALSKPDP-CVILKMQSHGQWFEVDRTEVIRTCINPVYSKLFT 80
C+T V+L ++C + D+D SK DP CV+L+ G W E+ RTE +R C +P +SK
Sbjct: 4 CVTLVQLSISCDHLIDKDIGSKSDPLCVLLQDVGGGSWAELGRTERVRNCSSPEFSKTLQ 63
Query: 81 VDFYFEEVQRLRFEVHDISSNHNGLKEADFLGGMECTLGQIVSQRKLSKSL-LKHGNTAG 139
+++ FE VQ+LRF ++DI + L++ DFLGG EC+LGQIVS + L+ L LK G AG
Sbjct: 64 LEYRFETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQVLTLPLMLKPGKPAG 123
Query: 140 KSSITVIAEELSGNDDYVELAFNARKLDDKDFFSKSDPFLEIFRMNDDATQQLVHRTEVV 199
+ +ITV A+EL N V + AR LD KDF KSDPFLE FR D LV+R+EV+
Sbjct: 124 RGTITVSAQELKDNR-VVTMEVEARNLDKKDFLGKSDPFLEFFRQGD-GKWHLVYRSEVI 181
Query: 200 MNNLSPAWKSFKVSVNSLCSGDPDRRLKCIVWDWDSNGKHDFIGEFTSTFKEMRGAMEGK 259
NNL+P WK F V V C G+P ++ D+DS+G HD IG F ++ +++
Sbjct: 182 KNNLNPTWKRFSVPVQHFCGGNPSTPIQVQCSDYDSDGSHDLIGTFHTSLAQLQAV---- 237
Query: 260 QVQWECINPKYKAKKKNYKNSGTVILNLCKIHKMHSFLDYIMGGCQIQFTVAIDFTASNG 319
++ECI+P+ + KKK+YKNSGT+ + +C++ +SFLDY+MGGCQI FTV +DFT SNG
Sbjct: 238 PAEFECIHPEKQQKKKSYKNSGTIRVKICRVETEYSFLDYVMGGCQINFTVGVDFTGSNG 297
Query: 320 DPRNSCSLHYIHPYQPNEYLKALVAVGEICQDYDSDKMFPAFGFGARIPPEYTVSHDFAI 379
DP + SLHY+ P NEYL AL +VG + QDYDSDK+FPAFGFGA++PP++ VSH+FA+
Sbjct: 298 DPSSPDSLHYLSPTGVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFAL 357
Query: 380 NFNEDNPECAGIQGVVEAYQSCLPKLQLYGPTNIAPIIQKVAKSASEETNTKEASQYFIL 439
NFN NP CAGIQG+V+AY+ LP+++LYGPTN APII VA+ A++ + ASQYF+L
Sbjct: 358 NFNPSNPYCAGIQGIVDAYRQALPQVRLYGPTNFAPIINHVARFAAQAAHQGTASQYFML 417
Query: 440 LILTDGVITDMADTREAIVHASHLPMSVIIVGVGNADFSDMQMLDGDDGILRSPKGEPVL 499
L+LTDG +TD+ TREA+V AS+LPMSVIIVGVG ADF M+ LD D G L + G+
Sbjct: 418 LLLTDGAVTDVEATREAVVRASNLPMSVIIVGVGGADFEAMEQLDADGGPLHTRSGQAAA 477
Query: 500 RDIVQFVPFRNFKHASPAALAKSVLAEVPNQVVDYYNGKGIKP 542
RDIVQFVP+R F++A ALA++VLAEVP Q+V Y+ +G P
Sbjct: 478 RDIVQFVPYRRFQNAPREALAQTVLAEVPTQLVSYFRAQGWAP 520
>gi|23397704 copine I isoform a [Homo sapiens]
Length = 537
Score = 547 bits (1409), Expect = e-155
Identities = 272/523 (52%), Positives = 366/523 (69%), Gaps = 8/523 (1%)
Query: 22 CLTKVELRVACKGISDRDALSKPDP-CVILKMQSHGQWFEVDRTEVIRTCINPVYSKLFT 80
C+T V+L ++C + D+D SK DP CV+L+ G W E+ RTE +R C +P +SK
Sbjct: 4 CVTLVQLSISCDHLIDKDIGSKSDPLCVLLQDVGGGSWAELGRTERVRNCSSPEFSKTLQ 63
Query: 81 VDFYFEEVQRLRFEVHDISSNHNGLKEADFLGGMECTLGQIVSQRKLSKSL-LKHGNTAG 139
+++ FE VQ+LRF ++DI + L++ DFLGG EC+LGQIVS + L+ L LK G AG
Sbjct: 64 LEYRFETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQVLTLPLMLKPGKPAG 123
Query: 140 KSSITVIAEELSGNDDYVELAFNARKLDDKDFFSKSDPFLEIFRMNDDATQQLVHRTEVV 199
+ +ITV A+EL N V + AR LD KDF KSDPFLE FR D LV+R+EV+
Sbjct: 124 RGTITVSAQELKDNR-VVTMEVEARNLDKKDFLGKSDPFLEFFRQGD-GKWHLVYRSEVI 181
Query: 200 MNNLSPAWKSFKVSVNSLCSGDPDRRLKCIVWDWDSNGKHDFIGEFTSTFKEMRGAMEGK 259
NNL+P WK F V V C G+P ++ D+DS+G HD IG F ++ +++
Sbjct: 182 KNNLNPTWKRFSVPVQHFCGGNPSTPIQVQCSDYDSDGSHDLIGTFHTSLAQLQAV---- 237
Query: 260 QVQWECINPKYKAKKKNYKNSGTVILNLCKIHKMHSFLDYIMGGCQIQFTVAIDFTASNG 319
++ECI+P+ + KKK+YKNSGT+ + +C++ +SFLDY+MGGCQI FTV +DFT SNG
Sbjct: 238 PAEFECIHPEKQQKKKSYKNSGTIRVKICRVETEYSFLDYVMGGCQINFTVGVDFTGSNG 297
Query: 320 DPRNSCSLHYIHPYQPNEYLKALVAVGEICQDYDSDKMFPAFGFGARIPPEYTVSHDFAI 379
DP + SLHY+ P NEYL AL +VG + QDYDSDK+FPAFGFGA++PP++ VSH+FA+
Sbjct: 298 DPSSPDSLHYLSPTGVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFAL 357
Query: 380 NFNEDNPECAGIQGVVEAYQSCLPKLQLYGPTNIAPIIQKVAKSASEETNTKEASQYFIL 439
NFN NP CAGIQG+V+AY+ LP+++LYGPTN APII VA+ A++ + ASQYF+L
Sbjct: 358 NFNPSNPYCAGIQGIVDAYRQALPQVRLYGPTNFAPIINHVARFAAQAAHQGTASQYFML 417
Query: 440 LILTDGVITDMADTREAIVHASHLPMSVIIVGVGNADFSDMQMLDGDDGILRSPKGEPVL 499
L+LTDG +TD+ TREA+V AS+LPMSVIIVGVG ADF M+ LD D G L + G+
Sbjct: 418 LLLTDGAVTDVEATREAVVRASNLPMSVIIVGVGGADFEAMEQLDADGGPLHTRSGQAAA 477
Query: 500 RDIVQFVPFRNFKHASPAALAKSVLAEVPNQVVDYYNGKGIKP 542
RDIVQFVP+R F++A ALA++VLAEVP Q+V Y+ +G P
Sbjct: 478 RDIVQFVPYRRFQNAPREALAQTVLAEVPTQLVSYFRAQGWAP 520
>gi|23397702 copine I isoform a [Homo sapiens]
Length = 537
Score = 547 bits (1409), Expect = e-155
Identities = 272/523 (52%), Positives = 366/523 (69%), Gaps = 8/523 (1%)
Query: 22 CLTKVELRVACKGISDRDALSKPDP-CVILKMQSHGQWFEVDRTEVIRTCINPVYSKLFT 80
C+T V+L ++C + D+D SK DP CV+L+ G W E+ RTE +R C +P +SK
Sbjct: 4 CVTLVQLSISCDHLIDKDIGSKSDPLCVLLQDVGGGSWAELGRTERVRNCSSPEFSKTLQ 63
Query: 81 VDFYFEEVQRLRFEVHDISSNHNGLKEADFLGGMECTLGQIVSQRKLSKSL-LKHGNTAG 139
+++ FE VQ+LRF ++DI + L++ DFLGG EC+LGQIVS + L+ L LK G AG
Sbjct: 64 LEYRFETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQVLTLPLMLKPGKPAG 123
Query: 140 KSSITVIAEELSGNDDYVELAFNARKLDDKDFFSKSDPFLEIFRMNDDATQQLVHRTEVV 199
+ +ITV A+EL N V + AR LD KDF KSDPFLE FR D LV+R+EV+
Sbjct: 124 RGTITVSAQELKDNR-VVTMEVEARNLDKKDFLGKSDPFLEFFRQGD-GKWHLVYRSEVI 181
Query: 200 MNNLSPAWKSFKVSVNSLCSGDPDRRLKCIVWDWDSNGKHDFIGEFTSTFKEMRGAMEGK 259
NNL+P WK F V V C G+P ++ D+DS+G HD IG F ++ +++
Sbjct: 182 KNNLNPTWKRFSVPVQHFCGGNPSTPIQVQCSDYDSDGSHDLIGTFHTSLAQLQAV---- 237
Query: 260 QVQWECINPKYKAKKKNYKNSGTVILNLCKIHKMHSFLDYIMGGCQIQFTVAIDFTASNG 319
++ECI+P+ + KKK+YKNSGT+ + +C++ +SFLDY+MGGCQI FTV +DFT SNG
Sbjct: 238 PAEFECIHPEKQQKKKSYKNSGTIRVKICRVETEYSFLDYVMGGCQINFTVGVDFTGSNG 297
Query: 320 DPRNSCSLHYIHPYQPNEYLKALVAVGEICQDYDSDKMFPAFGFGARIPPEYTVSHDFAI 379
DP + SLHY+ P NEYL AL +VG + QDYDSDK+FPAFGFGA++PP++ VSH+FA+
Sbjct: 298 DPSSPDSLHYLSPTGVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFAL 357
Query: 380 NFNEDNPECAGIQGVVEAYQSCLPKLQLYGPTNIAPIIQKVAKSASEETNTKEASQYFIL 439
NFN NP CAGIQG+V+AY+ LP+++LYGPTN APII VA+ A++ + ASQYF+L
Sbjct: 358 NFNPSNPYCAGIQGIVDAYRQALPQVRLYGPTNFAPIINHVARFAAQAAHQGTASQYFML 417
Query: 440 LILTDGVITDMADTREAIVHASHLPMSVIIVGVGNADFSDMQMLDGDDGILRSPKGEPVL 499
L+LTDG +TD+ TREA+V AS+LPMSVIIVGVG ADF M+ LD D G L + G+
Sbjct: 418 LLLTDGAVTDVEATREAVVRASNLPMSVIIVGVGGADFEAMEQLDADGGPLHTRSGQAAA 477
Query: 500 RDIVQFVPFRNFKHASPAALAKSVLAEVPNQVVDYYNGKGIKP 542
RDIVQFVP+R F++A ALA++VLAEVP Q+V Y+ +G P
Sbjct: 478 RDIVQFVPYRRFQNAPREALAQTVLAEVPTQLVSYFRAQGWAP 520
>gi|23397700 copine I isoform a [Homo sapiens]
Length = 537
Score = 547 bits (1409), Expect = e-155
Identities = 272/523 (52%), Positives = 366/523 (69%), Gaps = 8/523 (1%)
Query: 22 CLTKVELRVACKGISDRDALSKPDP-CVILKMQSHGQWFEVDRTEVIRTCINPVYSKLFT 80
C+T V+L ++C + D+D SK DP CV+L+ G W E+ RTE +R C +P +SK
Sbjct: 4 CVTLVQLSISCDHLIDKDIGSKSDPLCVLLQDVGGGSWAELGRTERVRNCSSPEFSKTLQ 63
Query: 81 VDFYFEEVQRLRFEVHDISSNHNGLKEADFLGGMECTLGQIVSQRKLSKSL-LKHGNTAG 139
+++ FE VQ+LRF ++DI + L++ DFLGG EC+LGQIVS + L+ L LK G AG
Sbjct: 64 LEYRFETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQVLTLPLMLKPGKPAG 123
Query: 140 KSSITVIAEELSGNDDYVELAFNARKLDDKDFFSKSDPFLEIFRMNDDATQQLVHRTEVV 199
+ +ITV A+EL N V + AR LD KDF KSDPFLE FR D LV+R+EV+
Sbjct: 124 RGTITVSAQELKDNR-VVTMEVEARNLDKKDFLGKSDPFLEFFRQGD-GKWHLVYRSEVI 181
Query: 200 MNNLSPAWKSFKVSVNSLCSGDPDRRLKCIVWDWDSNGKHDFIGEFTSTFKEMRGAMEGK 259
NNL+P WK F V V C G+P ++ D+DS+G HD IG F ++ +++
Sbjct: 182 KNNLNPTWKRFSVPVQHFCGGNPSTPIQVQCSDYDSDGSHDLIGTFHTSLAQLQAV---- 237
Query: 260 QVQWECINPKYKAKKKNYKNSGTVILNLCKIHKMHSFLDYIMGGCQIQFTVAIDFTASNG 319
++ECI+P+ + KKK+YKNSGT+ + +C++ +SFLDY+MGGCQI FTV +DFT SNG
Sbjct: 238 PAEFECIHPEKQQKKKSYKNSGTIRVKICRVETEYSFLDYVMGGCQINFTVGVDFTGSNG 297
Query: 320 DPRNSCSLHYIHPYQPNEYLKALVAVGEICQDYDSDKMFPAFGFGARIPPEYTVSHDFAI 379
DP + SLHY+ P NEYL AL +VG + QDYDSDK+FPAFGFGA++PP++ VSH+FA+
Sbjct: 298 DPSSPDSLHYLSPTGVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFAL 357
Query: 380 NFNEDNPECAGIQGVVEAYQSCLPKLQLYGPTNIAPIIQKVAKSASEETNTKEASQYFIL 439
NFN NP CAGIQG+V+AY+ LP+++LYGPTN APII VA+ A++ + ASQYF+L
Sbjct: 358 NFNPSNPYCAGIQGIVDAYRQALPQVRLYGPTNFAPIINHVARFAAQAAHQGTASQYFML 417
Query: 440 LILTDGVITDMADTREAIVHASHLPMSVIIVGVGNADFSDMQMLDGDDGILRSPKGEPVL 499
L+LTDG +TD+ TREA+V AS+LPMSVIIVGVG ADF M+ LD D G L + G+
Sbjct: 418 LLLTDGAVTDVEATREAVVRASNLPMSVIIVGVGGADFEAMEQLDADGGPLHTRSGQAAA 477
Query: 500 RDIVQFVPFRNFKHASPAALAKSVLAEVPNQVVDYYNGKGIKP 542
RDIVQFVP+R F++A ALA++VLAEVP Q+V Y+ +G P
Sbjct: 478 RDIVQFVPYRRFQNAPREALAQTVLAEVPTQLVSYFRAQGWAP 520
>gi|23397698 copine I isoform a [Homo sapiens]
Length = 537
Score = 547 bits (1409), Expect = e-155
Identities = 272/523 (52%), Positives = 366/523 (69%), Gaps = 8/523 (1%)
Query: 22 CLTKVELRVACKGISDRDALSKPDP-CVILKMQSHGQWFEVDRTEVIRTCINPVYSKLFT 80
C+T V+L ++C + D+D SK DP CV+L+ G W E+ RTE +R C +P +SK
Sbjct: 4 CVTLVQLSISCDHLIDKDIGSKSDPLCVLLQDVGGGSWAELGRTERVRNCSSPEFSKTLQ 63
Query: 81 VDFYFEEVQRLRFEVHDISSNHNGLKEADFLGGMECTLGQIVSQRKLSKSL-LKHGNTAG 139
+++ FE VQ+LRF ++DI + L++ DFLGG EC+LGQIVS + L+ L LK G AG
Sbjct: 64 LEYRFETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQVLTLPLMLKPGKPAG 123
Query: 140 KSSITVIAEELSGNDDYVELAFNARKLDDKDFFSKSDPFLEIFRMNDDATQQLVHRTEVV 199
+ +ITV A+EL N V + AR LD KDF KSDPFLE FR D LV+R+EV+
Sbjct: 124 RGTITVSAQELKDNR-VVTMEVEARNLDKKDFLGKSDPFLEFFRQGD-GKWHLVYRSEVI 181
Query: 200 MNNLSPAWKSFKVSVNSLCSGDPDRRLKCIVWDWDSNGKHDFIGEFTSTFKEMRGAMEGK 259
NNL+P WK F V V C G+P ++ D+DS+G HD IG F ++ +++
Sbjct: 182 KNNLNPTWKRFSVPVQHFCGGNPSTPIQVQCSDYDSDGSHDLIGTFHTSLAQLQAV---- 237
Query: 260 QVQWECINPKYKAKKKNYKNSGTVILNLCKIHKMHSFLDYIMGGCQIQFTVAIDFTASNG 319
++ECI+P+ + KKK+YKNSGT+ + +C++ +SFLDY+MGGCQI FTV +DFT SNG
Sbjct: 238 PAEFECIHPEKQQKKKSYKNSGTIRVKICRVETEYSFLDYVMGGCQINFTVGVDFTGSNG 297
Query: 320 DPRNSCSLHYIHPYQPNEYLKALVAVGEICQDYDSDKMFPAFGFGARIPPEYTVSHDFAI 379
DP + SLHY+ P NEYL AL +VG + QDYDSDK+FPAFGFGA++PP++ VSH+FA+
Sbjct: 298 DPSSPDSLHYLSPTGVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFAL 357
Query: 380 NFNEDNPECAGIQGVVEAYQSCLPKLQLYGPTNIAPIIQKVAKSASEETNTKEASQYFIL 439
NFN NP CAGIQG+V+AY+ LP+++LYGPTN APII VA+ A++ + ASQYF+L
Sbjct: 358 NFNPSNPYCAGIQGIVDAYRQALPQVRLYGPTNFAPIINHVARFAAQAAHQGTASQYFML 417
Query: 440 LILTDGVITDMADTREAIVHASHLPMSVIIVGVGNADFSDMQMLDGDDGILRSPKGEPVL 499
L+LTDG +TD+ TREA+V AS+LPMSVIIVGVG ADF M+ LD D G L + G+
Sbjct: 418 LLLTDGAVTDVEATREAVVRASNLPMSVIIVGVGGADFEAMEQLDADGGPLHTRSGQAAA 477
Query: 500 RDIVQFVPFRNFKHASPAALAKSVLAEVPNQVVDYYNGKGIKP 542
RDIVQFVP+R F++A ALA++VLAEVP Q+V Y+ +G P
Sbjct: 478 RDIVQFVPYRRFQNAPREALAQTVLAEVPTQLVSYFRAQGWAP 520
>gi|23397696 copine I isoform a [Homo sapiens]
Length = 537
Score = 547 bits (1409), Expect = e-155
Identities = 272/523 (52%), Positives = 366/523 (69%), Gaps = 8/523 (1%)
Query: 22 CLTKVELRVACKGISDRDALSKPDP-CVILKMQSHGQWFEVDRTEVIRTCINPVYSKLFT 80
C+T V+L ++C + D+D SK DP CV+L+ G W E+ RTE +R C +P +SK
Sbjct: 4 CVTLVQLSISCDHLIDKDIGSKSDPLCVLLQDVGGGSWAELGRTERVRNCSSPEFSKTLQ 63
Query: 81 VDFYFEEVQRLRFEVHDISSNHNGLKEADFLGGMECTLGQIVSQRKLSKSL-LKHGNTAG 139
+++ FE VQ+LRF ++DI + L++ DFLGG EC+LGQIVS + L+ L LK G AG
Sbjct: 64 LEYRFETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQVLTLPLMLKPGKPAG 123
Query: 140 KSSITVIAEELSGNDDYVELAFNARKLDDKDFFSKSDPFLEIFRMNDDATQQLVHRTEVV 199
+ +ITV A+EL N V + AR LD KDF KSDPFLE FR D LV+R+EV+
Sbjct: 124 RGTITVSAQELKDNR-VVTMEVEARNLDKKDFLGKSDPFLEFFRQGD-GKWHLVYRSEVI 181
Query: 200 MNNLSPAWKSFKVSVNSLCSGDPDRRLKCIVWDWDSNGKHDFIGEFTSTFKEMRGAMEGK 259
NNL+P WK F V V C G+P ++ D+DS+G HD IG F ++ +++
Sbjct: 182 KNNLNPTWKRFSVPVQHFCGGNPSTPIQVQCSDYDSDGSHDLIGTFHTSLAQLQAV---- 237
Query: 260 QVQWECINPKYKAKKKNYKNSGTVILNLCKIHKMHSFLDYIMGGCQIQFTVAIDFTASNG 319
++ECI+P+ + KKK+YKNSGT+ + +C++ +SFLDY+MGGCQI FTV +DFT SNG
Sbjct: 238 PAEFECIHPEKQQKKKSYKNSGTIRVKICRVETEYSFLDYVMGGCQINFTVGVDFTGSNG 297
Query: 320 DPRNSCSLHYIHPYQPNEYLKALVAVGEICQDYDSDKMFPAFGFGARIPPEYTVSHDFAI 379
DP + SLHY+ P NEYL AL +VG + QDYDSDK+FPAFGFGA++PP++ VSH+FA+
Sbjct: 298 DPSSPDSLHYLSPTGVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFAL 357
Query: 380 NFNEDNPECAGIQGVVEAYQSCLPKLQLYGPTNIAPIIQKVAKSASEETNTKEASQYFIL 439
NFN NP CAGIQG+V+AY+ LP+++LYGPTN APII VA+ A++ + ASQYF+L
Sbjct: 358 NFNPSNPYCAGIQGIVDAYRQALPQVRLYGPTNFAPIINHVARFAAQAAHQGTASQYFML 417
Query: 440 LILTDGVITDMADTREAIVHASHLPMSVIIVGVGNADFSDMQMLDGDDGILRSPKGEPVL 499
L+LTDG +TD+ TREA+V AS+LPMSVIIVGVG ADF M+ LD D G L + G+
Sbjct: 418 LLLTDGAVTDVEATREAVVRASNLPMSVIIVGVGGADFEAMEQLDADGGPLHTRSGQAAA 477
Query: 500 RDIVQFVPFRNFKHASPAALAKSVLAEVPNQVVDYYNGKGIKP 542
RDIVQFVP+R F++A ALA++VLAEVP Q+V Y+ +G P
Sbjct: 478 RDIVQFVPYRRFQNAPREALAQTVLAEVPTQLVSYFRAQGWAP 520
>gi|197333761 copine I isoform b [Homo sapiens]
Length = 542
Score = 547 bits (1409), Expect = e-155
Identities = 272/523 (52%), Positives = 366/523 (69%), Gaps = 8/523 (1%)
Query: 22 CLTKVELRVACKGISDRDALSKPDP-CVILKMQSHGQWFEVDRTEVIRTCINPVYSKLFT 80
C+T V+L ++C + D+D SK DP CV+L+ G W E+ RTE +R C +P +SK
Sbjct: 9 CVTLVQLSISCDHLIDKDIGSKSDPLCVLLQDVGGGSWAELGRTERVRNCSSPEFSKTLQ 68
Query: 81 VDFYFEEVQRLRFEVHDISSNHNGLKEADFLGGMECTLGQIVSQRKLSKSL-LKHGNTAG 139
+++ FE VQ+LRF ++DI + L++ DFLGG EC+LGQIVS + L+ L LK G AG
Sbjct: 69 LEYRFETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQVLTLPLMLKPGKPAG 128
Query: 140 KSSITVIAEELSGNDDYVELAFNARKLDDKDFFSKSDPFLEIFRMNDDATQQLVHRTEVV 199
+ +ITV A+EL N V + AR LD KDF KSDPFLE FR D LV+R+EV+
Sbjct: 129 RGTITVSAQELKDNR-VVTMEVEARNLDKKDFLGKSDPFLEFFRQGD-GKWHLVYRSEVI 186
Query: 200 MNNLSPAWKSFKVSVNSLCSGDPDRRLKCIVWDWDSNGKHDFIGEFTSTFKEMRGAMEGK 259
NNL+P WK F V V C G+P ++ D+DS+G HD IG F ++ +++
Sbjct: 187 KNNLNPTWKRFSVPVQHFCGGNPSTPIQVQCSDYDSDGSHDLIGTFHTSLAQLQAV---- 242
Query: 260 QVQWECINPKYKAKKKNYKNSGTVILNLCKIHKMHSFLDYIMGGCQIQFTVAIDFTASNG 319
++ECI+P+ + KKK+YKNSGT+ + +C++ +SFLDY+MGGCQI FTV +DFT SNG
Sbjct: 243 PAEFECIHPEKQQKKKSYKNSGTIRVKICRVETEYSFLDYVMGGCQINFTVGVDFTGSNG 302
Query: 320 DPRNSCSLHYIHPYQPNEYLKALVAVGEICQDYDSDKMFPAFGFGARIPPEYTVSHDFAI 379
DP + SLHY+ P NEYL AL +VG + QDYDSDK+FPAFGFGA++PP++ VSH+FA+
Sbjct: 303 DPSSPDSLHYLSPTGVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFAL 362
Query: 380 NFNEDNPECAGIQGVVEAYQSCLPKLQLYGPTNIAPIIQKVAKSASEETNTKEASQYFIL 439
NFN NP CAGIQG+V+AY+ LP+++LYGPTN APII VA+ A++ + ASQYF+L
Sbjct: 363 NFNPSNPYCAGIQGIVDAYRQALPQVRLYGPTNFAPIINHVARFAAQAAHQGTASQYFML 422
Query: 440 LILTDGVITDMADTREAIVHASHLPMSVIIVGVGNADFSDMQMLDGDDGILRSPKGEPVL 499
L+LTDG +TD+ TREA+V AS+LPMSVIIVGVG ADF M+ LD D G L + G+
Sbjct: 423 LLLTDGAVTDVEATREAVVRASNLPMSVIIVGVGGADFEAMEQLDADGGPLHTRSGQAAA 482
Query: 500 RDIVQFVPFRNFKHASPAALAKSVLAEVPNQVVDYYNGKGIKP 542
RDIVQFVP+R F++A ALA++VLAEVP Q+V Y+ +G P
Sbjct: 483 RDIVQFVPYRRFQNAPREALAQTVLAEVPTQLVSYFRAQGWAP 525
>gi|25121972 copine VIII [Homo sapiens]
Length = 564
Score = 525 bits (1352), Expect = e-149
Identities = 282/538 (52%), Positives = 366/538 (68%), Gaps = 20/538 (3%)
Query: 24 TKVELRVACKGISDRDALSKPDPCVILKMQSHG--QWFEVDRTEVIRTCINPVYSKLFTV 81
T+VE+ V+C+ + DRD SK DP +L +Q G +W E RTEVI +NP + + F +
Sbjct: 24 TRVEVSVSCRNLLDRDTFSKSDPICVLYVQGVGNKEWREFGRTEVIDNTLNPDFVRKFIL 83
Query: 82 DFYFEEVQRLRFEVHDISSNHNGLKEADFLGGMECTLGQIVSQR--KLSKSLLKHGNTAG 139
D++FEE + LRF+++D+ S L + DFLG + CTLG+IV + +L K ++ G
Sbjct: 84 DYFFEERENLRFDLYDVDSKSPNLSKHDFLGQVFCTLGEIVGSQGSRLEKPIV---GIPG 140
Query: 140 KSSITVI--AEELSGNDDYVELAFNARKLDDKDFFSKSDPFLEIFRMNDDATQQLVHRTE 197
K T+I AEEL+ D V + F A KLD KDFF KSDPFL +R N+D + + H+TE
Sbjct: 141 KKCGTIILTAEELNCCRDAVLMQFCANKLDKKDFFGKSDPFLVFYRSNEDGSFTICHKTE 200
Query: 198 VVMNNLSPAWKSFKVSVNSLCSGDPDRRLKCIVWDWDSNGKHDFIGEFTSTFKEMRGAME 257
VV N L+P W++FK+SV +LC+GD DR +K V+DWD +G HDFIGEFT++++E+
Sbjct: 201 VVKNTLNPVWQAFKISVRALCNGDYDRTIKVEVYDWDRDGSHDFIGEFTTSYRELSRGQS 260
Query: 258 GKQVQWECINPKYKAKKKNYKNSGTVILNLCKIHKMHSFLDYIMGGCQIQFTVAIDFTAS 317
V +E +NPK K KKK Y NSGTV L + SFLDYI GG QI FTVAIDFTAS
Sbjct: 261 QFNV-YEVVNPKKKGKKKKYTNSGTVTLLSFLVETEVSFLDYIKGGTQINFTVAIDFTAS 319
Query: 318 NGDPRNSCSLHYIHPYQPNEYLKALVAVGEICQDYDSDKMFPAFGFGARIPPEYTVSHDF 377
NG+P SLHY++PYQ N Y AL AVGEI QDYDSDKMFPA GFGA++PP+ +SH+F
Sbjct: 320 NGNPAQPTSLHYMNPYQLNAYGMALKAVGEIVQDYDSDKMFPALGFGAKLPPDGRISHEF 379
Query: 378 AINFNEDNPECAGIQGVVEAYQSCLPKLQLYGPTNIAPIIQKVAKSASEETNTKEASQYF 437
A+N N NP C GI+GV+EAY L +QLYGPTN AP+I VA+ AS + K+ SQYF
Sbjct: 380 ALNGNPQNPYCDGIEGVMEAYYRSLKSVQLYGPTNFAPVINHVARYAS---SVKDGSQYF 436
Query: 438 ILLILTDGVITDMADTREAIVHASHLPMSVIIVGVGNADFSDMQMLDGDDGILRSPKGEP 497
+LLI+TDGVI+DMA T+E+IV+AS LPMS+IIVGVG A+F M LDGDD + S +G+
Sbjct: 437 VLLIVTDGVISDMAQTKESIVNASKLPMSIIIVGVGPAEFDAMVELDGDD-VRVSSRGKY 495
Query: 498 VLRDIVQFVPFRNF-----KH-ASPAALAKSVLAEVPNQVVDYYNGKGIKPKCSSEMY 549
RDIVQFVPFR++ H S A LAK VLAE+P Q + Y +GIKP + Y
Sbjct: 496 AERDIVQFVPFRDYIDRSGNHILSMARLAKDVLAEIPEQFLSYMRARGIKPSPAPPPY 553
>gi|25141323 copine V [Homo sapiens]
Length = 593
Score = 515 bits (1326), Expect = e-146
Identities = 274/549 (49%), Positives = 361/549 (65%), Gaps = 34/549 (6%)
Query: 24 TKVELRVACKGISDRDALSKPDPCVILKMQS--HGQWFEVDRTEVIRTCINPVYSKLFTV 81
TKVE+ V+C+ + D+D SK DP ++ Q + QW E RTEVI +NP + + F V
Sbjct: 23 TKVEITVSCRNLLDKDMFSKSDPLCVMYTQGMENKQWREFGRTEVIDNTLNPDFVRKFIV 82
Query: 82 DFYFEEVQRLRFEVHDISSNHNGLKEADFLGGMECTLGQIVSQ--RKLSKSL-------- 131
D++FEE Q LRF+++D+ S L + DFLG CTLG+IV +L K L
Sbjct: 83 DYFFEEKQNLRFDLYDVDSKSPDLSKHDFLGQAFCTLGEIVGSPGSRLEKPLTIGAFSLN 142
Query: 132 ---------LKHGNTAGKSSITVI--AEELSGNDDYVELAFNARKLDDKDFFSKSDPFLE 180
+ +G GK T+I AEELS D + F A KLD KDFF KSDPFL
Sbjct: 143 SRTGKPMPAVSNGGVPGKKCGTIILSAEELSNCRDVATMQFCANKLDKKDFFGKSDPFLV 202
Query: 181 IFRMNDDATQQLVHRTEVVMNNLSPAWKSFKVSVNSLCSGDPDRRLKCIVWDWDSNGKHD 240
+R N+D T + H+TEV+ N L+P W++F + V +LC+GD DR +K V+DWD +G HD
Sbjct: 203 FYRSNEDGTFTICHKTEVMKNTLNPVWQTFSIPVRALCNGDYDRTIKVEVYDWDRDGSHD 262
Query: 241 FIGEFTSTFKEMRGAMEGKQVQWECINPKYKAKKKNYKNSGTVILNLCKIHKMHSFLDYI 300
FIGEFT++++E+ + +E +NPK K KKK Y NSGTV L + +FLDYI
Sbjct: 263 FIGEFTTSYRELARGQSQFNI-YEVVNPKKKMKKKKYVNSGTVTLLSFAVESECTFLDYI 321
Query: 301 MGGCQIQFTVAIDFTASNGDPRNSCSLHYIHPYQPNEYLKALVAVGEICQDYDSDKMFPA 360
GG QI FTVAIDFTASNG+P S SLHY+ PYQ N Y AL AVGEI Q YDSDKMFPA
Sbjct: 322 KGGTQINFTVAIDFTASNGNPSQSTSLHYMSPYQLNAYALALTAVGEIIQHYDSDKMFPA 381
Query: 361 FGFGARIPPEYTVSHDFAINFNEDNPECAGIQGVVEAYQSCLPKLQLYGPTNIAPIIQKV 420
GFGA++PP+ VSH+F +N N++NP C GI G++EAY L +QLYGPTN AP++ V
Sbjct: 382 LGFGAKLPPDGRVSHEFPLNGNQENPSCCGIDGILEAYHRSLRTVQLYGPTNFAPVVTHV 441
Query: 421 AKSASEETNTKEASQYFILLILTDGVITDMADTREAIVHASHLPMSVIIVGVGNADFSDM 480
A++A+ ++ SQY +LLI+TDGVI+DMA T+EAIV+A+ LPMS+IIVGVG A+F M
Sbjct: 442 ARNAAA---VQDGSQYSVLLIITDGVISDMAQTKEAIVNAAKLPMSIIIVGVGQAEFDAM 498
Query: 481 QMLDGDDGILRSPKGEPVLRDIVQFVPFRNF-----KHA-SPAALAKSVLAEVPNQVVDY 534
LDGDD + S +G+ RDIVQFVPFR++ H S A LA+ VLAE+P+Q+V Y
Sbjct: 499 VELDGDD-VRISSRGKLAERDIVQFVPFRDYVDRTGNHVLSMARLARDVLAEIPDQLVSY 557
Query: 535 YNGKGIKPK 543
+GI+P+
Sbjct: 558 MKAQGIRPR 566
>gi|88703066 copine-like protein [Homo sapiens]
Length = 553
Score = 497 bits (1279), Expect = e-140
Identities = 262/532 (49%), Positives = 355/532 (66%), Gaps = 20/532 (3%)
Query: 24 TKVELRVACKGISDRDALSKPDPCVILKMQSHG--QWFEVDRTEVIRTCINPVYSKLFTV 81
TK+E+ V+C+ + D D SK DP V+L QS +W E RTEVI +NP + + F +
Sbjct: 14 TKIEITVSCRNLLDLDTFSKSDPMVVLYTQSRASQEWREFGRTEVIDNTLNPDFVRKFVL 73
Query: 82 DFYFEEVQRLRFEVHDISSNHNGLKEADFLGGMECTLGQIVSQR--KLSKSLLKHGNTAG 139
D++FEE Q LRF+V+++ S N K DFLG LG+++ + ++ ++L G
Sbjct: 74 DYFFEEKQNLRFDVYNVDSKTNISKPKDFLGQAFLALGEVIGGQGSRVERTLT---GVPG 130
Query: 140 KSSITVI--AEELSGNDDYVELAFNARKLDDKDFFSKSDPFLEIFRMNDDATQQLVHRTE 197
K T++ AEELS D + A KLD KDFF KSDPFL +R N+D T + H+TE
Sbjct: 131 KKCGTILLTAEELSNCRDIATMQLCANKLDKKDFFGKSDPFLVFYRSNEDGTFTICHKTE 190
Query: 198 VVMNNLSPAWKSFKVSVNSLCSGDPDRRLKCIVWDWDSNGKHDFIGEFTSTFKEMRGAME 257
VV N L+P W+ F + V +LC+GD DR +K V+DWD +G HDFIGEFT++++E+ A
Sbjct: 191 VVKNTLNPVWQPFSIPVRALCNGDYDRTVKIDVYDWDRDGSHDFIGEFTTSYRELSKAQN 250
Query: 258 GKQVQWECINPKYKAKKKNYKNSGTVILNLCKIHKMHSFLDYIMGGCQIQFTVAIDFTAS 317
V +E +NP+ K KKK Y NSGTV L + +F+DYI GG Q+ FTVAIDFTAS
Sbjct: 251 QFTV-YEVLNPRKKCKKKKYVNSGTVTLLSFSVDSEFTFVDYIKGGTQLNFTVAIDFTAS 309
Query: 318 NGDPRNSCSLHYIHPYQPNEYLKALVAVGEICQDYDSDKMFPAFGFGARIPPEYTVSHDF 377
NG+P SLHY+ PYQ + Y AL AVGEI QDYDSDK+FPA+GFGA++PPE +SH F
Sbjct: 310 NGNPLQPTSLHYMSPYQLSAYAMALKAVGEIIQDYDSDKLFPAYGFGAKLPPEGRISHQF 369
Query: 378 AINFNEDNPECAGIQGVVEAYQSCLPKLQLYGPTNIAPIIQKVAKSASEETNTKEASQYF 437
+N N+++P CAGI+GV+E+Y L +QLYGPT AP+I +VA++A++ + SQY+
Sbjct: 370 PLNNNDEDPNCAGIEGVLESYFQSLRTVQLYGPTYFAPVINQVARAAAK---ISDGSQYY 426
Query: 438 ILLILTDGVITDMADTREAIVHASHLPMSVIIVGVGNADFSDMQMLDGDDGILRSPKGEP 497
+LLI+TDGVI+DM T+EAIV AS LPMS+IIVGVG A F M+ LDGDD + S +G
Sbjct: 427 VLLIITDGVISDMTQTKEAIVSASSLPMSIIIVGVGPAMFEAMEELDGDD-VRVSSRGRY 485
Query: 498 VLRDIVQFVPFRNF------KHASPAALAKSVLAEVPNQVVDYYNGKGIKPK 543
RDIVQFVPFR++ + S A LAK VLAE+P Q++ Y + I+P+
Sbjct: 486 AERDIVQFVPFRDYVDRSGNQVLSMARLAKDVLAEIPEQLLSYMRTRDIQPR 537
Score = 34.7 bits (78), Expect = 0.24
Identities = 21/60 (35%), Positives = 33/60 (55%), Gaps = 1/60 (1%)
Query: 147 AEELSGNDDYVELAFNARKLDDKDFFSKSDPFLEIFRMNDDATQ-QLVHRTEVVMNNLSP 205
A E S +E+ + R L D D FSKSDP + ++ + + + + RTEV+ N L+P
Sbjct: 6 ASERSVPATKIEITVSCRNLLDLDTFSKSDPMVVLYTQSRASQEWREFGRTEVIDNTLNP 65
>gi|13384594 protein kinase C, gamma [Homo sapiens]
Length = 697
Score = 52.8 bits (125), Expect = 8e-07
Identities = 38/145 (26%), Positives = 66/145 (45%), Gaps = 11/145 (7%)
Query: 113 GMECTLGQIVSQRKLSKSL-----LKHGNTAGKSSITVIAEELSGNDDYVELAFNARKLD 167
GM+C+ ++ R+ +S+ + H G+ + + A D+ AR L
Sbjct: 128 GMKCSCCEMNVHRRCVRSVPSLCGVDHTERRGRLQLEIRAPTA---DEIHVTVGEARNLI 184
Query: 168 DKDFFSKSDPFLEIFRMNDDATQQLVHRTEVVMNNLSPAWKSFKVSVNSLCSGDPDRRLK 227
D SDP++++ ++ D +T V L+P W + V +L GD +RRL
Sbjct: 185 PMDPNGLSDPYVKL-KLIPDPRNLTKQKTRTVKATLNPVWN--ETFVFNLKPGDVERRLS 241
Query: 228 CIVWDWDSNGKHDFIGEFTSTFKEM 252
VWDWD ++DF+G + E+
Sbjct: 242 VEVWDWDRTSRNDFMGAMSFGVSEL 266
Score = 29.3 bits (64), Expect = 9.9
Identities = 20/79 (25%), Positives = 37/79 (46%), Gaps = 5/79 (6%)
Query: 45 DPCVILKMQSHGQWFEVDRTEVIRTCINPVYSKLFTVDFYFEEVQ-RLRFEVHDISSNHN 103
DP V LK+ + +T ++ +NPV+++ F + +V+ RL EV D
Sbjct: 193 DPYVKLKLIPDPRNLTKQKTRTVKATLNPVWNETFVFNLKPGDVERRLSVEVWDWDRTSR 252
Query: 104 GLKEADFLGGMECTLGQIV 122
DF+G M + +++
Sbjct: 253 N----DFMGAMSFGVSELL 267
>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
Length = 671
Score = 50.8 bits (120), Expect = 3e-06
Identities = 28/103 (27%), Positives = 54/103 (52%), Gaps = 5/103 (4%)
Query: 154 DDYVELAFNARKLDDKDFFSKSDPFLEIFRMNDDATQQLVHRTEVVMNNLSPAW-KSFKV 212
D + L +A+ L D SDP++++ ++ D + +T+ + +L+P W ++F+
Sbjct: 171 DVLIVLVRDAKNLVPMDPNGLSDPYVKL-KLIPDPKSESKQKTKTIKCSLNPEWNETFRF 229
Query: 213 SVNSLCSGDPDRRLKCIVWDWDSNGKHDFIGEFTSTFKEMRGA 255
+ D DRRL +WDWD ++DF+G + E++ A
Sbjct: 230 QLKE---SDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKA 269
>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
Length = 673
Score = 50.8 bits (120), Expect = 3e-06
Identities = 28/103 (27%), Positives = 54/103 (52%), Gaps = 5/103 (4%)
Query: 154 DDYVELAFNARKLDDKDFFSKSDPFLEIFRMNDDATQQLVHRTEVVMNNLSPAW-KSFKV 212
D + L +A+ L D SDP++++ ++ D + +T+ + +L+P W ++F+
Sbjct: 171 DVLIVLVRDAKNLVPMDPNGLSDPYVKL-KLIPDPKSESKQKTKTIKCSLNPEWNETFRF 229
Query: 213 SVNSLCSGDPDRRLKCIVWDWDSNGKHDFIGEFTSTFKEMRGA 255
+ D DRRL +WDWD ++DF+G + E++ A
Sbjct: 230 QLKE---SDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKA 269
>gi|4506067 protein kinase C, alpha [Homo sapiens]
Length = 672
Score = 48.1 bits (113), Expect = 2e-05
Identities = 26/92 (28%), Positives = 48/92 (52%), Gaps = 5/92 (5%)
Query: 162 NARKLDDKDFFSKSDPFLEIFRMNDDATQQLVHRTEVVMNNLSPAW-KSFKVSVNSLCSG 220
+A+ L D SDP++++ ++ D + +T+ + + L+P W +SF +
Sbjct: 179 DAKNLIPMDPNGLSDPYVKL-KLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLKP---S 234
Query: 221 DPDRRLKCIVWDWDSNGKHDFIGEFTSTFKEM 252
D DRRL +WDWD ++DF+G + E+
Sbjct: 235 DKDRRLSVEIWDWDRTTRNDFMGSLSFGVSEL 266
>gi|28376627 synaptotagmin IX [Homo sapiens]
Length = 491
Score = 46.6 bits (109), Expect = 6e-05
Identities = 38/147 (25%), Positives = 65/147 (44%), Gaps = 10/147 (6%)
Query: 101 NHNGLKEADFLGGMECTLGQIVSQRKLSKSLLKHGNTAGKSSITVIAEELSGNDDYVELA 160
N L++ + L G+ ++ QR L + N+ + I + + +
Sbjct: 182 NIQQLQKQEQLTGIGRIKPELYKQRSLDNDDGRRSNSKACGKLNFILKYDCDLEQLIVKI 241
Query: 161 FNARKLDDKDFFSKSDPFLEIFRMNDDATQQLVHRTEVVMNNLSPAWKS---FKVSVNSL 217
A L KDF SDP+++I+ + D T+ H+T+V L+P + F V N L
Sbjct: 242 HKAVNLPAKDFSGTSDPYVKIYLLPDRKTK---HQTKVHRKTLNPVFDEVFLFPVPYNDL 298
Query: 218 CSGDPDRRLKCIVWDWDSNGKHDFIGE 244
R+L V+D+D +HD IG+
Sbjct: 299 ----EARKLHFSVYDFDRFSRHDLIGQ 321
Score = 29.6 bits (65), Expect = 7.6
Identities = 13/66 (19%), Positives = 28/66 (42%)
Query: 30 VACKGISDRDALSKPDPCVILKMQSHGQWFEVDRTEVIRTCINPVYSKLFTVDFYFEEVQ 89
+ + + D DP V + + G+ + +T R +NPVY++ D E +
Sbjct: 374 IKARNLKAMDITGASDPYVKVSLMCDGRRLKKRKTSTKRNTLNPVYNEAIVFDVPPENID 433
Query: 90 RLRFEV 95
++ +
Sbjct: 434 QIHLSI 439
>gi|150170670 piccolo isoform 2 [Homo sapiens]
Length = 4935
Score = 45.8 bits (107), Expect = 1e-04
Identities = 34/134 (25%), Positives = 60/134 (44%), Gaps = 17/134 (12%)
Query: 128 SKSLLKHGNTAGKSSITVIAEELSG------NDDYVELAFN---ARKLDDKDFFSKSDPF 178
S S KHG++ V++ ++G N D L + AR L +D SDPF
Sbjct: 4672 SVSKKKHGSSKPTDGTKVVSHPITGEIQLQINYDLGNLIIHILQARNLVPRDNNGYSDPF 4731
Query: 179 LEIFRMN--------DDATQQLVHRTEVVMNNLSPAWKSFKVSVNSLCSGDPDRRLKCIV 230
++++ + +A+ + RT+ V +L+P W + + + L+ V
Sbjct: 4732 VKVYLLPGRGQVMVVQNASAEYKRRTKHVQKSLNPEWNQTVIYKSISMEQLKKKTLEVTV 4791
Query: 231 WDWDSNGKHDFIGE 244
WD+D +DF+GE
Sbjct: 4792 WDYDRFSSNDFLGE 4805
>gi|150378539 piccolo isoform 1 [Homo sapiens]
Length = 5142
Score = 45.8 bits (107), Expect = 1e-04
Identities = 34/134 (25%), Positives = 60/134 (44%), Gaps = 17/134 (12%)
Query: 128 SKSLLKHGNTAGKSSITVIAEELSG------NDDYVELAFN---ARKLDDKDFFSKSDPF 178
S S KHG++ V++ ++G N D L + AR L +D SDPF
Sbjct: 4672 SVSKKKHGSSKPTDGTKVVSHPITGEIQLQINYDLGNLIIHILQARNLVPRDNNGYSDPF 4731
Query: 179 LEIFRMN--------DDATQQLVHRTEVVMNNLSPAWKSFKVSVNSLCSGDPDRRLKCIV 230
++++ + +A+ + RT+ V +L+P W + + + L+ V
Sbjct: 4732 VKVYLLPGRGQVMVVQNASAEYKRRTKHVQKSLNPEWNQTVIYKSISMEQLKKKTLEVTV 4791
Query: 231 WDWDSNGKHDFIGE 244
WD+D +DF+GE
Sbjct: 4792 WDYDRFSSNDFLGE 4805
>gi|39752671 synaptotagmin X [Homo sapiens]
Length = 523
Score = 40.0 bits (92), Expect = 0.006
Identities = 40/141 (28%), Positives = 63/141 (44%), Gaps = 16/141 (11%)
Query: 112 GGMECTLGQIVSQRKLSKSLLKHGNT------AGKSSITVIAEELSGNDDYVELAFNARK 165
G ++G+I + KS+ GN GK + T+ + N+ V A
Sbjct: 200 GETTTSIGRIKPELYKQKSVDSEGNQNEDVKICGKLNFTLQYDY--ENELLVVKIIKALD 257
Query: 166 LDDKDFFSKSDPFLEIFRMNDDAT--QQLVHRTEVVMNNLSPAWKSFKVSVNSLCSGDPD 223
L KDF SDP+++++ + D Q VHR +N L F V+ + L +
Sbjct: 258 LPAKDFTGTSDPYVKMYLLPDRKKKFQTRVHRK--TLNPLFDETFQFPVAYDQLSN---- 311
Query: 224 RRLKCIVWDWDSNGKHDFIGE 244
R+L V+D+D +HD IGE
Sbjct: 312 RKLHFSVYDFDRFSRHDMIGE 332
Score = 32.0 bits (71), Expect = 1.5
Identities = 14/66 (21%), Positives = 29/66 (43%)
Query: 30 VACKGISDRDALSKPDPCVILKMQSHGQWFEVDRTEVIRTCINPVYSKLFTVDFYFEEVQ 89
+ C+ + D DP V + + G+ + +T + +NPVY++ D E V
Sbjct: 385 IKCRNLKAMDITGSSDPYVKVSLMCEGRRLKKRKTTTKKNTLNPVYNEAIIFDIPPENVD 444
Query: 90 RLRFEV 95
++ +
Sbjct: 445 QVSLSI 450
>gi|6005997 double C2-like domains, beta [Homo sapiens]
Length = 412
Score = 39.3 bits (90), Expect = 0.010
Identities = 46/230 (20%), Positives = 91/230 (39%), Gaps = 31/230 (13%)
Query: 33 KGISDRDALSKPDPCVILKMQSHGQWFEVDRTEVIRTCINPVYSKLFTVDFYFEEVQRLR 92
KG+ D DP V L + RT+ +R +NP +++ T + + +R
Sbjct: 151 KGLKPMDHNGLADPYVKLHLLPGASKANKLRTKTLRNTLNPTWNETLTY-YGITDEDMIR 209
Query: 93 FEVHDISSNHNGLKEADFLGGMECTLGQIVSQRKLSKSLLKHGNTAGKSSITVIAEELSG 152
+ + + + +F+G L +KL + K N + + V E
Sbjct: 210 KTLRISVCDEDKFRHNEFIGETRVPL------KKLKPNHTKTFNICLEKQLPVDKTEDKS 263
Query: 153 NDD----YVELAFNARK------------LDDKDFFSKSDPFLEIFRMNDDATQQLVHRT 196
++ + L ++++K L D SDP+++ + + D ++ H+T
Sbjct: 264 LEERGRILISLKYSSQKQGLLVGIVRCAHLAAMDANGYSDPYVKTY-LRPDVDKKSKHKT 322
Query: 197 EVVMNNLSPAWKS---FKVSVNSLCSGDPDRRLKCIVWDWDSNGKHDFIG 243
V L+P + +++ L + L+ VWD+D +DFIG
Sbjct: 323 AVKKKTLNPEFNEEFCYEIKHGDLAK----KSLEVTVWDYDIGKSNDFIG 368
>gi|45504376 synaptotagmin VI [Homo sapiens]
Length = 425
Score = 38.9 bits (89), Expect = 0.013
Identities = 27/82 (32%), Positives = 41/82 (50%), Gaps = 10/82 (12%)
Query: 166 LDDKDFFSKSDPFLEIFRMNDDATQQLVHRTEVVMNNLSPAWKS---FKVSVNSLCSGDP 222
L KDF SDP+++I+ + D ++ +T V L+P + F V L
Sbjct: 171 LPAKDFCGSSDPYVKIYLLPD---RKCKLQTRVHRKTLNPTFDENFHFPVPYEELA---- 223
Query: 223 DRRLKCIVWDWDSNGKHDFIGE 244
DR+L V+D+D +HD IGE
Sbjct: 224 DRKLHLSVFDFDRFSRHDMIGE 245
Score = 29.6 bits (65), Expect = 7.6
Identities = 13/62 (20%), Positives = 29/62 (46%)
Query: 30 VACKGISDRDALSKPDPCVILKMQSHGQWFEVDRTEVIRTCINPVYSKLFTVDFYFEEVQ 89
+ C+ + D DP V + + G+ + +T + + +NPVY++ D E +
Sbjct: 298 IKCRNLKAMDITGYSDPYVKVSLLCDGRRLKKKKTTIKKNTLNPVYNEAIIFDIPPENMD 357
Query: 90 RL 91
++
Sbjct: 358 QV 359
>gi|238550198 synaptotagmin III [Homo sapiens]
Length = 590
Score = 38.5 bits (88), Expect = 0.016
Identities = 32/113 (28%), Positives = 51/113 (45%), Gaps = 10/113 (8%)
Query: 135 GNTAGKSSITVIAEELSGNDDYVELAFNARKLDDKDFFSKSDPFLEIFRMNDDATQQLVH 194
G A I+ L G+D V A L KD SDP+++I+ + D ++
Sbjct: 295 GTGAPCGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPD---RKKKF 351
Query: 195 RTEVVMNNLSPAWK---SFKVSVNSLCSGDPDRRLKCIVWDWDSNGKHDFIGE 244
+T+V L+P + F V + L R+L V+D+D +HD IG+
Sbjct: 352 QTKVHRKTLNPVFNETFQFSVPLAELA----QRKLHFSVYDFDRFSRHDLIGQ 400
>gi|238550196 synaptotagmin III [Homo sapiens]
Length = 590
Score = 38.5 bits (88), Expect = 0.016
Identities = 32/113 (28%), Positives = 51/113 (45%), Gaps = 10/113 (8%)
Query: 135 GNTAGKSSITVIAEELSGNDDYVELAFNARKLDDKDFFSKSDPFLEIFRMNDDATQQLVH 194
G A I+ L G+D V A L KD SDP+++I+ + D ++
Sbjct: 295 GTGAPCGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPD---RKKKF 351
Query: 195 RTEVVMNNLSPAWK---SFKVSVNSLCSGDPDRRLKCIVWDWDSNGKHDFIGE 244
+T+V L+P + F V + L R+L V+D+D +HD IG+
Sbjct: 352 QTKVHRKTLNPVFNETFQFSVPLAELA----QRKLHFSVYDFDRFSRHDLIGQ 400
>gi|14150054 synaptotagmin III [Homo sapiens]
Length = 590
Score = 38.5 bits (88), Expect = 0.016
Identities = 32/113 (28%), Positives = 51/113 (45%), Gaps = 10/113 (8%)
Query: 135 GNTAGKSSITVIAEELSGNDDYVELAFNARKLDDKDFFSKSDPFLEIFRMNDDATQQLVH 194
G A I+ L G+D V A L KD SDP+++I+ + D ++
Sbjct: 295 GTGAPCGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPD---RKKKF 351
Query: 195 RTEVVMNNLSPAWK---SFKVSVNSLCSGDPDRRLKCIVWDWDSNGKHDFIGE 244
+T+V L+P + F V + L R+L V+D+D +HD IG+
Sbjct: 352 QTKVHRKTLNPVFNETFQFSVPLAELA----QRKLHFSVYDFDRFSRHDLIGQ 400
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.405
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,818,054
Number of Sequences: 37866
Number of extensions: 896068
Number of successful extensions: 2022
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 31
Number of HSP's successfully gapped in prelim test: 69
Number of HSP's that attempted gapping in prelim test: 1795
Number of HSP's gapped (non-prelim): 189
length of query: 557
length of database: 18,247,518
effective HSP length: 107
effective length of query: 450
effective length of database: 14,195,856
effective search space: 6388135200
effective search space used: 6388135200
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.