Search of human proteins with 169790956

Search of human proteins with 169790956

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|169790956 methionine synthase reductase isoform 2 [Homo
sapiens]
         (725 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|169790956 methionine synthase reductase isoform 2 [Homo sapiens]  1450   0.0  
gi|169790958 methionine synthase reductase isoform 1 [Homo sapiens]  1400   0.0  
gi|40254422 nitric oxide synthase 3 isoform 1 [Homo sapiens]          219   7e-57
gi|10835173 nitric oxide synthase 1, neuronal [Homo sapiens]          218   1e-56
gi|127139033 cytochrome P450 reductase [Homo sapiens]                 211   2e-54
gi|24041029 nitric oxide synthase 2A [Homo sapiens]                   188   2e-47
gi|221316705 NADPH dependent diflavin oxidoreductase 1 isoform a...   181   3e-45
gi|7657393 NADPH dependent diflavin oxidoreductase 1 isoform b [...   180   5e-45
gi|221316709 NADPH dependent diflavin oxidoreductase 1 isoform c...   166   5e-41
gi|221316707 NADPH dependent diflavin oxidoreductase 1 isoform d...   145   1e-34
gi|50726981 radical S-adenosyl methionine and flavodoxin domains...    47   8e-05
gi|62241003 cardiomyopathy associated 5 [Homo sapiens]                 39   0.013
gi|231571329 nitric oxide synthase 3 isoform 3 [Homo sapiens]          39   0.017
gi|231571356 nitric oxide synthase 3 isoform 4 [Homo sapiens]          38   0.038
gi|231571314 nitric oxide synthase 3 isoform 2 [Homo sapiens]          38   0.038
gi|55742678 glucocorticoid induced transcript 1 [Homo sapiens]         38   0.038
gi|113722133 senataxin [Homo sapiens]                                  34   0.42 
gi|116805344 proline rich, lacrimal 1 [Homo sapiens]                   32   2.1  
gi|8923900 cytidine monophospho-N-acetylneuraminic acid syntheta...    32   2.7  
gi|156416003 succinate dehydrogenase complex, subunit A, flavopr...    31   3.5  
gi|153792230 hypothetical protein LOC57670 [Homo sapiens]              31   3.5  
gi|153251766 hypothetical protein LOC56181 isoform a [Homo sapiens]    30   6.0  
gi|153251748 hypothetical protein LOC56181 isoform a [Homo sapiens]    30   6.0  
gi|153251745 hypothetical protein LOC56181 isoform a [Homo sapiens]    30   6.0  
gi|19923907 oxidoreductase NAD-binding domain containing 1 [Homo...    30   6.0  
gi|38569394 inhibitor of kappa light polypeptide gene enhancer i...    30   7.9  

>gi|169790956 methionine synthase reductase isoform 2 [Homo sapiens]
          Length = 725

 Score = 1450 bits (3754), Expect = 0.0
 Identities = 725/725 (100%), Positives = 725/725 (100%)

Query: 1   MGAASVRAGARLVEVALCSFTVTCLEVMRRFLLLYATQQGQAKAIAEEICEQAVVHGFSA 60
           MGAASVRAGARLVEVALCSFTVTCLEVMRRFLLLYATQQGQAKAIAEEICEQAVVHGFSA
Sbjct: 1   MGAASVRAGARLVEVALCSFTVTCLEVMRRFLLLYATQQGQAKAIAEEICEQAVVHGFSA 60

Query: 61  DLHCISESDKYDLKTETAPLVVVVSTTGTGDPPDTARKFVKEIQNQTLPVDFFAHLRYGL 120
           DLHCISESDKYDLKTETAPLVVVVSTTGTGDPPDTARKFVKEIQNQTLPVDFFAHLRYGL
Sbjct: 61  DLHCISESDKYDLKTETAPLVVVVSTTGTGDPPDTARKFVKEIQNQTLPVDFFAHLRYGL 120

Query: 121 LGLGDSEYTYFCNGGKIIDKRLQELGARHFYDTGHADDCVGLELVVEPWIAGLWPALRKH 180
           LGLGDSEYTYFCNGGKIIDKRLQELGARHFYDTGHADDCVGLELVVEPWIAGLWPALRKH
Sbjct: 121 LGLGDSEYTYFCNGGKIIDKRLQELGARHFYDTGHADDCVGLELVVEPWIAGLWPALRKH 180

Query: 181 FRSSRGQEEISGALPVASPASSRTDLVKSELLHIESQVELLRFDDSGRKDSEVLKQNAVN 240
           FRSSRGQEEISGALPVASPASSRTDLVKSELLHIESQVELLRFDDSGRKDSEVLKQNAVN
Sbjct: 181 FRSSRGQEEISGALPVASPASSRTDLVKSELLHIESQVELLRFDDSGRKDSEVLKQNAVN 240

Query: 241 SNQSNVVIEDFESSLTRSVPPLSQASLNIPGLPPEYLQVHLQESLGQEESQVSVTSADPV 300
           SNQSNVVIEDFESSLTRSVPPLSQASLNIPGLPPEYLQVHLQESLGQEESQVSVTSADPV
Sbjct: 241 SNQSNVVIEDFESSLTRSVPPLSQASLNIPGLPPEYLQVHLQESLGQEESQVSVTSADPV 300

Query: 301 FQVPISKAVQLTTNDAIKTTLLVELDISNTDFSYQPGDAFSVICPNSDSEVQSLLQRLQL 360
           FQVPISKAVQLTTNDAIKTTLLVELDISNTDFSYQPGDAFSVICPNSDSEVQSLLQRLQL
Sbjct: 301 FQVPISKAVQLTTNDAIKTTLLVELDISNTDFSYQPGDAFSVICPNSDSEVQSLLQRLQL 360

Query: 361 EDKREHCVLLKIKADTKKKGATLPQHIPAGCSLQFIFTWCLEIRAIPKKAFLRALVDYTS 420
           EDKREHCVLLKIKADTKKKGATLPQHIPAGCSLQFIFTWCLEIRAIPKKAFLRALVDYTS
Sbjct: 361 EDKREHCVLLKIKADTKKKGATLPQHIPAGCSLQFIFTWCLEIRAIPKKAFLRALVDYTS 420

Query: 421 DSAEKRRLQELCSKQGAADYSRFVRDACACLLDLLLAFPSCQPPLSLLLEHLPKLQPRPY 480
           DSAEKRRLQELCSKQGAADYSRFVRDACACLLDLLLAFPSCQPPLSLLLEHLPKLQPRPY
Sbjct: 421 DSAEKRRLQELCSKQGAADYSRFVRDACACLLDLLLAFPSCQPPLSLLLEHLPKLQPRPY 480

Query: 481 SCASSSLFHPGKLHFVFNIVEFLSTATTEVLRKGVCTGWLALLVASVLQPNIHASHEDSG 540
           SCASSSLFHPGKLHFVFNIVEFLSTATTEVLRKGVCTGWLALLVASVLQPNIHASHEDSG
Sbjct: 481 SCASSSLFHPGKLHFVFNIVEFLSTATTEVLRKGVCTGWLALLVASVLQPNIHASHEDSG 540

Query: 541 KALAPKISISPRTTNSFHLPDDPSIPIIMVGPGTGIAPFIGFLQHREKLQEQHPDGNFGA 600
           KALAPKISISPRTTNSFHLPDDPSIPIIMVGPGTGIAPFIGFLQHREKLQEQHPDGNFGA
Sbjct: 541 KALAPKISISPRTTNSFHLPDDPSIPIIMVGPGTGIAPFIGFLQHREKLQEQHPDGNFGA 600

Query: 601 MWLFFGCRHKDRDYLFRKELRHFLKHGILTHLKVSFSRDAPVGEEEAPAKYVQDNIQLHG 660
           MWLFFGCRHKDRDYLFRKELRHFLKHGILTHLKVSFSRDAPVGEEEAPAKYVQDNIQLHG
Sbjct: 601 MWLFFGCRHKDRDYLFRKELRHFLKHGILTHLKVSFSRDAPVGEEEAPAKYVQDNIQLHG 660

Query: 661 QQVARILLQENGHIYVCGDAKNMAKDVHDALVQIISKEVGVEKLEAMKTLATLKEEKRYL 720
           QQVARILLQENGHIYVCGDAKNMAKDVHDALVQIISKEVGVEKLEAMKTLATLKEEKRYL
Sbjct: 661 QQVARILLQENGHIYVCGDAKNMAKDVHDALVQIISKEVGVEKLEAMKTLATLKEEKRYL 720

Query: 721 QDIWS 725
           QDIWS
Sbjct: 721 QDIWS 725


>gi|169790958 methionine synthase reductase isoform 1 [Homo sapiens]
          Length = 698

 Score = 1400 bits (3623), Expect = 0.0
 Identities = 698/698 (100%), Positives = 698/698 (100%)

Query: 28  MRRFLLLYATQQGQAKAIAEEICEQAVVHGFSADLHCISESDKYDLKTETAPLVVVVSTT 87
           MRRFLLLYATQQGQAKAIAEEICEQAVVHGFSADLHCISESDKYDLKTETAPLVVVVSTT
Sbjct: 1   MRRFLLLYATQQGQAKAIAEEICEQAVVHGFSADLHCISESDKYDLKTETAPLVVVVSTT 60

Query: 88  GTGDPPDTARKFVKEIQNQTLPVDFFAHLRYGLLGLGDSEYTYFCNGGKIIDKRLQELGA 147
           GTGDPPDTARKFVKEIQNQTLPVDFFAHLRYGLLGLGDSEYTYFCNGGKIIDKRLQELGA
Sbjct: 61  GTGDPPDTARKFVKEIQNQTLPVDFFAHLRYGLLGLGDSEYTYFCNGGKIIDKRLQELGA 120

Query: 148 RHFYDTGHADDCVGLELVVEPWIAGLWPALRKHFRSSRGQEEISGALPVASPASSRTDLV 207
           RHFYDTGHADDCVGLELVVEPWIAGLWPALRKHFRSSRGQEEISGALPVASPASSRTDLV
Sbjct: 121 RHFYDTGHADDCVGLELVVEPWIAGLWPALRKHFRSSRGQEEISGALPVASPASSRTDLV 180

Query: 208 KSELLHIESQVELLRFDDSGRKDSEVLKQNAVNSNQSNVVIEDFESSLTRSVPPLSQASL 267
           KSELLHIESQVELLRFDDSGRKDSEVLKQNAVNSNQSNVVIEDFESSLTRSVPPLSQASL
Sbjct: 181 KSELLHIESQVELLRFDDSGRKDSEVLKQNAVNSNQSNVVIEDFESSLTRSVPPLSQASL 240

Query: 268 NIPGLPPEYLQVHLQESLGQEESQVSVTSADPVFQVPISKAVQLTTNDAIKTTLLVELDI 327
           NIPGLPPEYLQVHLQESLGQEESQVSVTSADPVFQVPISKAVQLTTNDAIKTTLLVELDI
Sbjct: 241 NIPGLPPEYLQVHLQESLGQEESQVSVTSADPVFQVPISKAVQLTTNDAIKTTLLVELDI 300

Query: 328 SNTDFSYQPGDAFSVICPNSDSEVQSLLQRLQLEDKREHCVLLKIKADTKKKGATLPQHI 387
           SNTDFSYQPGDAFSVICPNSDSEVQSLLQRLQLEDKREHCVLLKIKADTKKKGATLPQHI
Sbjct: 301 SNTDFSYQPGDAFSVICPNSDSEVQSLLQRLQLEDKREHCVLLKIKADTKKKGATLPQHI 360

Query: 388 PAGCSLQFIFTWCLEIRAIPKKAFLRALVDYTSDSAEKRRLQELCSKQGAADYSRFVRDA 447
           PAGCSLQFIFTWCLEIRAIPKKAFLRALVDYTSDSAEKRRLQELCSKQGAADYSRFVRDA
Sbjct: 361 PAGCSLQFIFTWCLEIRAIPKKAFLRALVDYTSDSAEKRRLQELCSKQGAADYSRFVRDA 420

Query: 448 CACLLDLLLAFPSCQPPLSLLLEHLPKLQPRPYSCASSSLFHPGKLHFVFNIVEFLSTAT 507
           CACLLDLLLAFPSCQPPLSLLLEHLPKLQPRPYSCASSSLFHPGKLHFVFNIVEFLSTAT
Sbjct: 421 CACLLDLLLAFPSCQPPLSLLLEHLPKLQPRPYSCASSSLFHPGKLHFVFNIVEFLSTAT 480

Query: 508 TEVLRKGVCTGWLALLVASVLQPNIHASHEDSGKALAPKISISPRTTNSFHLPDDPSIPI 567
           TEVLRKGVCTGWLALLVASVLQPNIHASHEDSGKALAPKISISPRTTNSFHLPDDPSIPI
Sbjct: 481 TEVLRKGVCTGWLALLVASVLQPNIHASHEDSGKALAPKISISPRTTNSFHLPDDPSIPI 540

Query: 568 IMVGPGTGIAPFIGFLQHREKLQEQHPDGNFGAMWLFFGCRHKDRDYLFRKELRHFLKHG 627
           IMVGPGTGIAPFIGFLQHREKLQEQHPDGNFGAMWLFFGCRHKDRDYLFRKELRHFLKHG
Sbjct: 541 IMVGPGTGIAPFIGFLQHREKLQEQHPDGNFGAMWLFFGCRHKDRDYLFRKELRHFLKHG 600

Query: 628 ILTHLKVSFSRDAPVGEEEAPAKYVQDNIQLHGQQVARILLQENGHIYVCGDAKNMAKDV 687
           ILTHLKVSFSRDAPVGEEEAPAKYVQDNIQLHGQQVARILLQENGHIYVCGDAKNMAKDV
Sbjct: 601 ILTHLKVSFSRDAPVGEEEAPAKYVQDNIQLHGQQVARILLQENGHIYVCGDAKNMAKDV 660

Query: 688 HDALVQIISKEVGVEKLEAMKTLATLKEEKRYLQDIWS 725
           HDALVQIISKEVGVEKLEAMKTLATLKEEKRYLQDIWS
Sbjct: 661 HDALVQIISKEVGVEKLEAMKTLATLKEEKRYLQDIWS 698


>gi|40254422 nitric oxide synthase 3 isoform 1 [Homo sapiens]
          Length = 1203

 Score =  219 bits (558), Expect = 7e-57
 Identities = 200/746 (26%), Positives = 311/746 (41%), Gaps = 161/746 (21%)

Query: 33   LLYATQQGQAKAIAEEICEQAVVHGFSADLHCISESDKYDLKTETAPLVVVVSTTGTGDP 92
            +LY ++ G+A++ A+++  +     F   + C+ E D   L+ ET  LVV  ST G GDP
Sbjct: 522  ILYGSETGRAQSYAQQL-GRLFRKAFDPRVLCMDEYDVVSLEHETLVLVVT-STFGNGDP 579

Query: 93   PDTARKFVKEIQNQTLPVDF---------------------------------------- 112
            P+    F   +   + P +                                         
Sbjct: 580  PENGESFAAALMEMSGPYNSSPRPEQHKSYKIRFNSISCSDPLVSSWRRKRKESSNTDSA 639

Query: 113  --FAHLRYGLLGLGDSEYTYFCNGGKIIDKRLQELGARHFYDTGHADDCVGLELVVEPWI 170
                 LR+ + GLG   Y +FC   + +D RL+ELG       G  D+  G E     W 
Sbjct: 640  GALGTLRFCVFGLGSRAYPHFCAFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWA 699

Query: 171  AGLWPALRKHFRSSRGQEEISGALPVASPASSRTDLVKSELLHIESQVELLRFDDSGRKD 230
               + A  + F    G++  + A  + SP  S     K +   + +Q E L+        
Sbjct: 700  QAAFQAACETF--CVGEDAKAAARDIFSPKRS----WKRQRYRLSAQAEGLQL------- 746

Query: 231  SEVLKQNAVNSNQSNVVIEDFESSLTRSVPPLSQASLNIPGLPPEYLQVHLQESLGQEES 290
                                                  +PGL    + VH ++       
Sbjct: 747  --------------------------------------LPGL----IHVHRRKMF----- 759

Query: 291  QVSVTSADPVFQVPISKAVQLTTNDAIKTTLLVELDISNTD-FSYQPGDAFSVICPNSDS 349
            Q ++ S +            L ++ + + T+LV LD    +   YQPGD   V  PN   
Sbjct: 760  QATIRSVE-----------NLQSSKSTRATILVRLDTGGQEGLQYQPGDHIGVCPPNRPG 808

Query: 350  EVQSLLQRLQLEDKREHCVLLKIKADTKKKGATLPQHIPAG---------CSLQFIFTWC 400
             V++LL R++            +  +  +KG+  P   P G         C+L+   T+ 
Sbjct: 809  LVEALLSRVEDPPAPTE----PVAVEQLEKGS--PGGPPPGWVRDPRLPPCTLRQALTFF 862

Query: 401  LEIRAIPKKAFLRALVDYTSDSAEKRRLQELCSKQGAADYSRFVRDACACLLDLLLAFPS 460
            L+I + P    LR L     +  E++ L+ L   Q    Y  +    C  LL++L  FPS
Sbjct: 863  LDITSPPSPQLLRLLSTLAEEPREQQELEAL--SQDPRRYEEWKWFRCPTLLEVLEQFPS 920

Query: 461  CQPPLSLLLEHLPKLQPRPYSCASSSLFHPGKLHFVFNIVEFLSTATTEVLRKGVCTGWL 520
               P  LLL  LP LQPR YS +S+   HPG++H    ++ + +      L  GVC+ WL
Sbjct: 921  VALPAPLLLTQLPLLQPRYYSVSSAPSTHPGEIHLTVAVLAYRTQDGLGPLHYGVCSTWL 980

Query: 521  ALLVASVLQPNIHASHEDSGKALAPKISISPRTTNSFHLPDDPSIPIIMVGPGTGIAPFI 580
                 S L+P                +    R   SF LP DPS+P I+VGPGTGIAPF 
Sbjct: 981  -----SQLKP-------------GDPVPCFIRGAPSFRLPPDPSLPCILVGPGTGIAPFR 1022

Query: 581  GFLQHREKLQEQHPDG-NFGAMWLFFGCRHKDRDYLFRKELRHFLKHGILTHLKVSFSRD 639
            GF Q  E+L +    G     M L FGCR    D+L+R E+++  + G+   +  +FSR 
Sbjct: 1023 GFWQ--ERLHDIESKGLQPTPMTLVFGCRCSQLDHLYRDEVQNAQQRGVFGRVLTAFSR- 1079

Query: 640  APVGEEEAPAKYVQDNIQLH-GQQVARILLQENGHIYVCGDAKNMAKDVHDALVQIISKE 698
                E + P  YVQD ++     +V R+L  E GH++VCGD   MA +V   + +I++ E
Sbjct: 1080 ----EPDNPKTYVQDILRTELAAEVHRVLCLERGHMFVCGDV-TMATNVLQTVQRILATE 1134

Query: 699  VGVEKLEAMKTLATLKEEKRYLQDIW 724
              +E  EA   +  L++++RY +DI+
Sbjct: 1135 GDMELDEAGDVIGVLRDQQRYHEDIF 1160


>gi|10835173 nitric oxide synthase 1, neuronal [Homo sapiens]
          Length = 1434

 Score =  218 bits (556), Expect = 1e-56
 Identities = 199/740 (26%), Positives = 313/740 (42%), Gaps = 149/740 (20%)

Query: 33   LLYATQQGQAKAIAEEICEQAVVHGFSADLHCISESDKYDLKTETAPLVVVVSTTGTGDP 92
            +LYAT+ G+++A A+ +CE    H F A +  + E D   L+ ET  LVV  ST G GDP
Sbjct: 762  ILYATETGKSQAYAKTLCE-IFKHAFDAKVMSMEEYDIVHLEHETLVLVVT-STFGNGDP 819

Query: 93   PDTARKF------------VKEIQNQTLPVDF---------------------------- 112
            P+   KF            V+E + ++  V F                            
Sbjct: 820  PENGEKFGCALMEMRHPNSVQE-ERKSYKVRFNSVSSYSDSQKSSGDGPDLRDNFESAGP 878

Query: 113  FAHLRYGLLGLGDSEYTYFCNGGKIIDKRLQELGARHFYDTGHADDCVGLELVVEPWIAG 172
             A++R+ + GLG   Y +FC  G  +D  L+ELG          D+  G E     W   
Sbjct: 879  LANVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDELCGQEEAFRTWA-- 936

Query: 173  LWPALRKHFRSSRGQEEISGALPVASPASSRTDLVKSELLHIESQVELLRFDDSGRKDSE 232
                 +K F+++                         ++  +   V + + ++S   +  
Sbjct: 937  -----KKVFKAA------------------------CDVFCVGDDVNIEKANNSLISNDR 967

Query: 233  VLKQNAVNSNQSNVVIEDFESSLTRSVPPLSQASLNIPGLPPEYLQVHLQESLGQEESQV 292
              K+N             F  +     P L+Q   N+        +V     L ++  Q 
Sbjct: 968  SWKRNK------------FRLTFVAEAPELTQGLSNV-----HKKRVSAARLLSRQNLQS 1010

Query: 293  SVTSADPVFQVPISKAVQLTTNDAIKTTLLVELDISNTDFSYQPGDAFSVICPNSDSEVQ 352
              +S   +F       V+L TN              + +  YQPGD   V   N +  V 
Sbjct: 1011 PKSSRSTIF-------VRLHTN-------------GSQELQYQPGDHLGVFPGNHEDLVN 1050

Query: 353  SLLQRLQLEDKREHCVLLKIKADTKKKGA-------TLPQHIPAGCSLQFIFTWCLEIRA 405
            +L++RL  ED      ++K++   ++  A       T    +P  C++   F + L+I  
Sbjct: 1051 ALIERL--EDAPPVNQMVKVELLEERNTALGVISNWTDELRLPP-CTIFQAFKYYLDITT 1107

Query: 406  IPKKAFLRALVDYTSDSAEKRRLQELCSKQGAADYSRFVRDACACLLDLLLAFPSCQPPL 465
             P    L+      +   EK+RL  L   +G  +Y  +       ++++L  FPS Q P 
Sbjct: 1108 PPTPLQLQQFASLATSEKEKQRL--LVLSKGLQEYEEWKWGKNPTIVEVLEEFPSIQMPA 1165

Query: 466  SLLLEHLPKLQPRPYSCASSSLFHPGKLHFVFNIVEFLSTATTEVLRKGVCTGWLALLVA 525
            +LLL  L  LQPR YS +SS   +P ++H    IV + +      +  GVC+ WL  + A
Sbjct: 1166 TLLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIVSYRTRDGEGPIHHGVCSSWLNRIQA 1225

Query: 526  SVLQPNIHASHEDSGKALAPKISISPRTTNSFHLPDDPSIPIIMVGPGTGIAPFIGFLQH 585
              L P                     R   SFHLP +P +P I+VGPGTGIAPF  F Q 
Sbjct: 1226 DELVP------------------CFVRGAPSFHLPRNPQVPCILVGPGTGIAPFRSFWQQ 1267

Query: 586  REKLQEQHPDGNFGAMWLFFGCRHKDRDYLFRKELRHFLKHGILTHLKVSFSRDAPVGEE 645
            R+    QH   N   M L FGCR    D+++R+E       G+   L  ++SR     E 
Sbjct: 1268 RQ-FDIQHKGMNPCPMVLVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSR-----EP 1321

Query: 646  EAPAKYVQDNIQLH-GQQVARILLQENGHIYVCGDAKNMAKDVHDALVQIISKEVGVEKL 704
            + P KYVQD +Q    + V R L ++ GHIYVCGD   MA DV  A+ +I++++  +   
Sbjct: 1322 DKPKKYVQDILQEQLAESVYRALKEQGGHIYVCGDV-TMAADVLKAIQRIMTQQGKLSAE 1380

Query: 705  EAMKTLATLKEEKRYLQDIW 724
            +A   ++ ++++ RY +DI+
Sbjct: 1381 DAGVFISRMRDDNRYHEDIF 1400


>gi|127139033 cytochrome P450 reductase [Homo sapiens]
          Length = 680

 Score =  211 bits (536), Expect = 2e-54
 Identities = 147/448 (32%), Positives = 227/448 (50%), Gaps = 37/448 (8%)

Query: 285 LGQEESQVSVTSADPVFQVPISKAVQLTTNDAI-----KTTLLVELDISNTDFSYQPGDA 339
           +G+     S  +  P F         +TTN  +     +  + +ELDIS++   Y+ GD 
Sbjct: 263 MGEMGRLKSYENQKPPFDAKNPFLAAVTTNRKLNQGTERHLMHLELDISDSKIRYESGDH 322

Query: 340 FSVICPNSDSEVQSLLQRLQLEDKREHCVLLKIKADTKKKGATLPQHIPAGCSLQFIFTW 399
            +V  P +DS + + L ++   D      L  +  ++ KK        P   S +   T+
Sbjct: 323 VAVY-PANDSALVNQLGKILGADLDVVMSLNNLDEESNKK-----HPFPCPTSYRTALTY 376

Query: 400 CLEIRAIPKKAFLRALVDYTSDSAEKRRLQELCSKQGAAD--YSRFVRDACACLLDLLLA 457
            L+I   P+   L  L  Y S+ +E+  L+++ S  G     Y  +V +A   +L +L  
Sbjct: 377 YLDITNPPRTNVLYELAQYASEPSEQELLRKMASSSGEGKELYLSWVVEARRHILAILQD 436

Query: 458 FPSCQPPLSLLLEHLPKLQPRPYSCASSSLFHPGKLHFVFNIVEFLSTATTEVLRKGVCT 517
            PS +PP+  L E LP+LQ R YS ASSS  HP  +H    +VE+ + A    + KGV T
Sbjct: 437 CPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVVVEYETKAGR--INKGVAT 494

Query: 518 GWLALLVASVLQPNIHASHEDSGKALAPKISISPRTTNSFHLPDDPSIPIIMVGPGTGIA 577
            WL              + E+ G+AL P         + F LP   + P+IMVGPGTG+A
Sbjct: 495 NWLRAK---------EPAGENGGRALVPMFV----RKSQFRLPFKATTPVIMVGPGTGVA 541

Query: 578 PFIGFLQHREKLQEQHPDGNFGAMWLFFGCRHKDRDYLFRKELRHFLKHGILTHLKVSFS 637
           PFIGF+Q R  L++Q  +   G   L++GCR  D DYL+R+EL  F + G LT L V+FS
Sbjct: 542 PFIGFIQERAWLRQQGKE--VGETLLYYGCRRSDEDYLYREELAQFHRDGALTQLNVAFS 599

Query: 638 RDAPVGEEEAPAKYVQDNIQLHGQQVARILLQENGHIYVCGDAKNMAKDVHDALVQIISK 697
           R      E++   YVQ  ++   + + + L++   HIYVCGDA+NMA+DV +    I+++
Sbjct: 600 R------EQSHKVYVQHLLKQDREHLWK-LIEGGAHIYVCGDARNMARDVQNTFYDIVAE 652

Query: 698 EVGVEKLEAMKTLATLKEEKRYLQDIWS 725
              +E  +A+  +  L  + RY  D+WS
Sbjct: 653 LGAMEHAQAVDYIKKLMTKGRYSLDVWS 680



 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 53/177 (29%), Positives = 85/177 (48%), Gaps = 7/177 (3%)

Query: 19  SFTVTCLEVMRRFLLLYATQQGQAKAIAEEICEQAVVHGFSADLHCISESDKYDLKT--- 75
           SF     +  R  ++ Y +Q G A+  A  + + A  +G         E D  DL +   
Sbjct: 71  SFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLADLSSLPE 130

Query: 76  -ETAPLVVVVSTTGTGDPPDTARKFVKEIQNQTLPVDFFAHLRYGLLGLGDSEYTYFCNG 134
            + A +V  ++T G GDP D A+ F   +Q   + +   + +++ + GLG+  Y +F   
Sbjct: 131 IDNALVVFCMATYGEGDPTDNAQDFYDWLQETDVDL---SGVKFAVFGLGNKTYEHFNAM 187

Query: 135 GKIIDKRLQELGARHFYDTGHADDCVGLELVVEPWIAGLWPALRKHFRSSRGQEEIS 191
           GK +DKRL++LGA+  ++ G  DD   LE     W    WPA+ +HF      EE S
Sbjct: 188 GKYVDKRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEHFGVEATGEESS 244


>gi|24041029 nitric oxide synthase 2A [Homo sapiens]
          Length = 1153

 Score =  188 bits (477), Expect = 2e-47
 Identities = 138/459 (30%), Positives = 221/459 (48%), Gaps = 33/459 (7%)

Query: 268  NIPGLPPEYLQVHLQESLGQEESQVSVTSADPVFQVPISKAVQLTTNDAIKTTLLVELDI 327
            N+   P  Y  V   + L   ++ +S   A  VF + +     L +  + + T+LVEL  
Sbjct: 701  NVTWDPHHYRLVQDSQPLDLSKA-LSSMHAKNVFTMRLKSRQNLQSPTSSRATILVELSC 759

Query: 328  SNTD-FSYQPGDAFSVICPNSDSEVQSLLQRLQLEDKREHCVLLKIKADTKKKGATLPQH 386
             +    +Y PG+   V   N  + VQ +L+R+ ++    H  +     D         + 
Sbjct: 760  EDGQGLNYLPGEHLGVCPGNQPALVQGILERV-VDGPTPHQTVRLEALDESGSYWVSDKR 818

Query: 387  IPAGCSLQFIFTWCLEIRAIPKKAFLRALVDYTSDSAEKRRLQELCSKQGAADYSRFVRD 446
            +P  CSL    T+ L+I   P +  L+ L    ++  E++RL+ LC     ++YS++   
Sbjct: 819  LPP-CSLSQALTYFLDITTPPTQLLLQKLAQVATEEPERQRLEALCQP---SEYSKWKFT 874

Query: 447  ACACLLDLLLAFPSCQPPLSLLLEHLPKLQPRPYSCASSSLFHPGKLHFVFNIVEFLSTA 506
                 L++L  FPS +     LL  LP L+PR YS +SS    P ++H    +V + +  
Sbjct: 875  NSPTFLEVLEEFPSLRVSAGFLLSQLPILKPRFYSISSSRDHTPTEIHLTVAVVTYHTRD 934

Query: 507  TTEVLRKGVCTGWLALLVASVLQPNIHASHEDSGKALAPKISISPRTTNSFHLPDDPSIP 566
                L  GVC+ WL     + L+P                +    R  + FHLP+DPS P
Sbjct: 935  GQGPLHHGVCSTWL-----NSLKPQ-------------DPVPCFVRNASGFHLPEDPSHP 976

Query: 567  IIMVGPGTGIAPFIGFLQHREKLQEQHPDGNFGAMWLFFGCRHKDRDYLFRKELRHFLKH 626
             I++GPGTGIAPF  F Q R     QH     G M L FGCR  D D+++++E+    + 
Sbjct: 977  CILIGPGTGIAPFRSFWQQRLH-DSQHKGVRGGRMTLVFGCRRPDEDHIYQEEMLEMAQK 1035

Query: 627  GILTHLKVSFSRDAPVGEEEAPAKYVQDNI-QLHGQQVARILLQENGHIYVCGDAKNMAK 685
            G+L  +  ++SR         P  YVQD + Q    +V R+L +E GH+YVCGD + MA+
Sbjct: 1036 GVLHAVHTAYSR-----LPGKPKVYVQDILRQQLASEVLRVLHKEPGHLYVCGDVR-MAR 1089

Query: 686  DVHDALVQIISKEVGVEKLEAMKTLATLKEEKRYLQDIW 724
            DV   L Q+++ ++ + + +       LK +KRY +DI+
Sbjct: 1090 DVAHTLKQLVAAKLKLNEEQVEDYFFQLKSQKRYHEDIF 1128



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 52/169 (30%), Positives = 76/169 (44%), Gaps = 22/169 (13%)

Query: 30  RFLLLYATQQGQAKAIAEEICEQAVVHGFSADLHCISESDKYDLKT--ETAPLVVVVSTT 87
           R  +L+AT+ G+++A+A ++        F+  + C+   DKY L    E   L+VV ST 
Sbjct: 538 RVTILFATETGKSEALAWDL-GALFSCAFNPKVVCM---DKYRLSCLEEERLLLVVTSTF 593

Query: 88  GTGDPPDTARKF------VKEIQNQTLPVDFFAHLRYGLLGLGDSEYTYFCNGGKIIDKR 141
           G GD P    K       +KE+ N+          RY + GLG S Y  FC     ID++
Sbjct: 594 GNGDCPGNGEKLKKSLFMLKELNNK---------FRYAVFGLGSSMYPRFCAFAHDIDQK 644

Query: 142 LQELGARHFYDTGHADDCVGLELVVEPWIAGLWPALRKHFRSSRGQEEI 190
           L  LGA      G  D+  G E     W    + A  + F   RG++ I
Sbjct: 645 LSHLGASQLTPMGEGDELSGQEDAFRSWAVQTFKAACETF-DVRGKQHI 692


>gi|221316705 NADPH dependent diflavin oxidoreductase 1 isoform a
           [Homo sapiens]
          Length = 606

 Score =  181 bits (458), Expect = 3e-45
 Identities = 138/480 (28%), Positives = 230/480 (47%), Gaps = 48/480 (10%)

Query: 260 PPLSQASLNIPGLPPEYLQVHLQE--SLGQEESQVS------VTSADPVFQVPISKAVQL 311
           P L++    +P LP ++  + LQE  S G E  +V+        S    F  P+    ++
Sbjct: 161 PGLTEIPPGVP-LPSKFTLLFLQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRV 219

Query: 312 TTNDAIKTTLLVELDISNTDFSYQPGDAFSVICPNSDSEVQSLLQRLQLEDKREHCVLLK 371
           T     +   L+E DI  +  S+  GD   +   NS + VQ   Q L L+  +   +   
Sbjct: 220 TGPSHFQDVRLIEFDILGSGISFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFML--- 276

Query: 372 IKADTKKKGATLPQHIPAGCSLQFIFTWCLEIRAIPKKAFLRALVDYTSDSAEKRRLQEL 431
                ++   + P  +P  CS++ + +  L+I ++P+++F   L   +    E+ +L E 
Sbjct: 277 ---QPREPDVSSPTRLPQPCSMRHLVSHYLDIASVPRRSFFELLACLSLHELEREKLLEF 333

Query: 432 CSKQGAADYSRFVRDACACLLDLLLAFP--SCQPPLSLLLEHLPKLQPRPYSCASSSLFH 489
            S QG  +   +       +L++L  FP  +   P   LL+ +P ++PR +S ASS L H
Sbjct: 334 SSAQGQEELFEYCNRPRRTILEVLCDFPHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTH 393

Query: 490 PGKLHFVFNIVEFLSTATTEVLRKGVCTGWLALLVASVLQPNIHASHEDSGKA-LAPKIS 548
           P +L  +  +V+F +       R+G+C+ WLA L              D G+  +   + 
Sbjct: 394 PSRLQILVAVVQFQTRLKEP--RRGLCSSWLASL--------------DPGQGPVRVPLW 437

Query: 549 ISPRTTNSFHLPDDPSIPIIMVGPGTGIAPFIGFLQHREKLQEQHPDGNFGAMWLFFGCR 608
           + P    S   P+ P  P+IMVGPGTG+APF   +Q R     Q   GNF    LFFGCR
Sbjct: 438 VRP---GSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVA---QGQTGNF----LFFGCR 487

Query: 609 HKDRDYLFRKELRHFLKHGILTHLKVSFSRDAPVGEEEAPAK---YVQDNIQLHGQQVAR 665
            +D+D+ +  E +   K   LT L  +FSR+ P     A  +   YVQ  ++  G  V  
Sbjct: 488 WRDQDFYWEAEWQELEKRDCLT-LIPAFSREQPPALFSALQEQKVYVQHRLRELGSLVWE 546

Query: 666 ILLQENGHIYVCGDAKNMAKDVHDALVQIISKEVGVEKLEAMKTLATLKEEKRYLQDIWS 725
           +L ++  + Y+ G+AK+M  DV +AL+ I  +E G+   +A   LA L++ +R+  + W+
Sbjct: 547 LLDRQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAAAYLARLQQTRRFQTETWA 606



 Score = 77.0 bits (188), Expect = 6e-14
 Identities = 51/172 (29%), Positives = 82/172 (47%), Gaps = 5/172 (2%)

Query: 30  RFLLLYATQQGQAKAIAEEICEQAVVHGFSADLHCISESDKYDLKTETAPLVVVV-STTG 88
           + L+L+ +Q G A+ ++E +  +A        +  +      +L  E  PLV+ V +TTG
Sbjct: 5   QLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINE--PLVIFVCATTG 62

Query: 89  TGDPPDTARKFVKEIQNQTLPVDFFAHLRYGLLGLGDSEYTYFCNGGKIIDKRLQELGAR 148
            GDPPD  + F + I  + LP      + + +LGLGDS Y  F    K + +RL +LG  
Sbjct: 63  QGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLGGS 122

Query: 149 HFYDTGHADDC--VGLELVVEPWIAGLWPALRKHFRSSRGQEEISGALPVAS 198
                   DD   +G +  V+PW+  LW  +   +    G  EI   +P+ S
Sbjct: 123 ALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPS 174


>gi|7657393 NADPH dependent diflavin oxidoreductase 1 isoform b
           [Homo sapiens]
          Length = 597

 Score =  180 bits (456), Expect = 5e-45
 Identities = 137/477 (28%), Positives = 228/477 (47%), Gaps = 51/477 (10%)

Query: 260 PPLSQASLNIPGLPPEYLQVHLQE--SLGQEESQVS------VTSADPVFQVPISKAVQL 311
           P L++    +P LP ++  + LQE  S G E  +V+        S    F  P+    ++
Sbjct: 161 PGLTEIPPGVP-LPSKFTLLFLQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRV 219

Query: 312 TTNDAIKTTLLVELDISNTDFSYQPGDAFSVICPNSDSEVQSLLQRLQLEDKREHCVLLK 371
           T     +   L+E DI  +  S+  GD   +   NS + VQ   Q L L+  +   +   
Sbjct: 220 TGPSHFQDVRLIEFDILGSGISFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFML--- 276

Query: 372 IKADTKKKGATLPQHIPAGCSLQFIFTWCLEIRAIPKKAFLRALVDYTSDSAEKRRLQEL 431
                ++   + P  +P  CS++ + +  L+I ++P+++F   L   +    E+ +L E 
Sbjct: 277 ---QPREPDVSSPTRLPQPCSMRHLVSHYLDIASVPRRSFFELLACLSLHELEREKLLEF 333

Query: 432 CSKQGAADYSRFVRDACACLLDLLLAFP--SCQPPLSLLLEHLPKLQPRPYSCASSSLFH 489
            S QG  +   +       +L++L  FP  +   P   LL+ +P ++PR +S ASS L H
Sbjct: 334 SSAQGQEELFEYCNRPRRTILEVLCDFPHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTH 393

Query: 490 PGKLHFVFNIVEFLSTATTEVLRKGVCTGWLALLVASVLQPNIHASHEDSGKA-LAPKIS 548
           P +L  +  +V+F +       R+G+C+ WLA L              D G+  +   + 
Sbjct: 394 PSRLQILVAVVQFQTRLKEP--RRGLCSSWLASL--------------DPGQGPVRVPLW 437

Query: 549 ISPRTTNSFHLPDDPSIPIIMVGPGTGIAPFIGFLQHREKLQEQHPDGNFGAMWLFFGCR 608
           + P    S   P+ P  P+IMVGPGTG+APF   +Q R     Q   GNF    LFFGCR
Sbjct: 438 VRP---GSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVA---QGQTGNF----LFFGCR 487

Query: 609 HKDRDYLFRKELRHFLKHGILTHLKVSFSRDAPVGEEEAPAKYVQDNIQLHGQQVARILL 668
            +D+D+ +  E +   K   LT L  +FSR      E+    YVQ  ++  G  V  +L 
Sbjct: 488 WRDQDFYWEAEWQELEKRDCLT-LIPAFSR------EQEQKVYVQHRLRELGSLVWELLD 540

Query: 669 QENGHIYVCGDAKNMAKDVHDALVQIISKEVGVEKLEAMKTLATLKEEKRYLQDIWS 725
           ++  + Y+ G+AK+M  DV +AL+ I  +E G+   +A   LA L++ +R+  + W+
Sbjct: 541 RQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAAAYLARLQQTRRFQTETWA 597



 Score = 77.0 bits (188), Expect = 6e-14
 Identities = 51/172 (29%), Positives = 82/172 (47%), Gaps = 5/172 (2%)

Query: 30  RFLLLYATQQGQAKAIAEEICEQAVVHGFSADLHCISESDKYDLKTETAPLVVVV-STTG 88
           + L+L+ +Q G A+ ++E +  +A        +  +      +L  E  PLV+ V +TTG
Sbjct: 5   QLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINE--PLVIFVCATTG 62

Query: 89  TGDPPDTARKFVKEIQNQTLPVDFFAHLRYGLLGLGDSEYTYFCNGGKIIDKRLQELGAR 148
            GDPPD  + F + I  + LP      + + +LGLGDS Y  F    K + +RL +LG  
Sbjct: 63  QGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLGGS 122

Query: 149 HFYDTGHADDC--VGLELVVEPWIAGLWPALRKHFRSSRGQEEISGALPVAS 198
                   DD   +G +  V+PW+  LW  +   +    G  EI   +P+ S
Sbjct: 123 ALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPS 174


>gi|221316709 NADPH dependent diflavin oxidoreductase 1 isoform c
           [Homo sapiens]
          Length = 590

 Score =  166 bits (421), Expect = 5e-41
 Identities = 134/477 (28%), Positives = 222/477 (46%), Gaps = 58/477 (12%)

Query: 260 PPLSQASLNIPGLPPEYLQVHLQE--SLGQEESQVS------VTSADPVFQVPISKAVQL 311
           P L++    +P LP ++  + LQE  S G E  +V+        S    F  P+    ++
Sbjct: 161 PGLTEIPPGVP-LPSKFTLLFLQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRV 219

Query: 312 TTNDAIKTTLLVELDISNTDFSYQPGDAFSVICPNSDSEVQSLLQRLQLEDKREHCVLLK 371
           T     +   L+E DI  +  S+  GD   +   NS + VQ   Q L L+  +   +   
Sbjct: 220 TGPSHFQDVRLIEFDILGSGISFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFML--- 276

Query: 372 IKADTKKKGATLPQHIPAGCSLQFIFTWCLEIRAIPKKAFLRALVDYTSDSAEKRRLQEL 431
                ++   + P  +P  CS++ + +  L+I ++P+++F   L   +    E+ +L E 
Sbjct: 277 ---QPREPDVSSPTRLPQPCSMRHLVSHYLDIASVPRRSFFELLACLSLHELEREKLLEF 333

Query: 432 CSKQGAADYSRFVRDACACLLDLLLAFP--SCQPPLSLLLEHLPKLQPRPYSCASSSLFH 489
            S QG  +   +       +L++L  FP  +   P   LL+ +P ++PR +S ASS L  
Sbjct: 334 SSAQGQEELFEYCNRPRRTILEVLCDFPHTAAAIPPDYLLDLIPVIRPRAFSIASSLLIL 393

Query: 490 PGKLHFVFNIVEFLSTATTEVLRKGVCTGWLALLVASVLQPNIHASHEDSGKA-LAPKIS 548
              + F   + E          R+G+C+ WLA L              D G+  +   + 
Sbjct: 394 VAVVQFQTRLKE---------PRRGLCSSWLASL--------------DPGQGPVRVPLW 430

Query: 549 ISPRTTNSFHLPDDPSIPIIMVGPGTGIAPFIGFLQHREKLQEQHPDGNFGAMWLFFGCR 608
           + P    S   P+ P  P+IMVGPGTG+APF   +Q R     Q   GNF    LFFGCR
Sbjct: 431 VRP---GSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVA---QGQTGNF----LFFGCR 480

Query: 609 HKDRDYLFRKELRHFLKHGILTHLKVSFSRDAPVGEEEAPAKYVQDNIQLHGQQVARILL 668
            +D+D+ +  E +   K   LT L  +FSR      E+    YVQ  ++  G  V  +L 
Sbjct: 481 WRDQDFYWEAEWQELEKRDCLT-LIPAFSR------EQEQKVYVQHRLRELGSLVWELLD 533

Query: 669 QENGHIYVCGDAKNMAKDVHDALVQIISKEVGVEKLEAMKTLATLKEEKRYLQDIWS 725
           ++  + Y+ G+AK+M  DV +AL+ I  +E G+   +A   LA L++ +R+  + W+
Sbjct: 534 RQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAAAYLARLQQTRRFQTETWA 590



 Score = 77.0 bits (188), Expect = 6e-14
 Identities = 51/172 (29%), Positives = 82/172 (47%), Gaps = 5/172 (2%)

Query: 30  RFLLLYATQQGQAKAIAEEICEQAVVHGFSADLHCISESDKYDLKTETAPLVVVV-STTG 88
           + L+L+ +Q G A+ ++E +  +A        +  +      +L  E  PLV+ V +TTG
Sbjct: 5   QLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINE--PLVIFVCATTG 62

Query: 89  TGDPPDTARKFVKEIQNQTLPVDFFAHLRYGLLGLGDSEYTYFCNGGKIIDKRLQELGAR 148
            GDPPD  + F + I  + LP      + + +LGLGDS Y  F    K + +RL +LG  
Sbjct: 63  QGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLGGS 122

Query: 149 HFYDTGHADDC--VGLELVVEPWIAGLWPALRKHFRSSRGQEEISGALPVAS 198
                   DD   +G +  V+PW+  LW  +   +    G  EI   +P+ S
Sbjct: 123 ALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPS 174


>gi|221316707 NADPH dependent diflavin oxidoreductase 1 isoform d
           [Homo sapiens]
          Length = 521

 Score =  145 bits (366), Expect = 1e-34
 Identities = 117/408 (28%), Positives = 188/408 (46%), Gaps = 50/408 (12%)

Query: 271 GLPPEYLQVHLQE--SLGQEESQVS------VTSADPVFQVPISKAVQLTTNDAIKTTLL 322
           GLP ++  + LQE  S G E  +V+        S    F  P+    ++T     +   L
Sbjct: 137 GLPSKFTLLFLQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRL 196

Query: 323 VELDISNTDFSYQPGDAFSVICPNSDSEVQSLLQRLQLEDKREHCVLLKIKADTKKKGAT 382
           +E DI  +  S+  GD   +   NS + VQ   Q L L+  +   +        ++   +
Sbjct: 197 IEFDILGSGISFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFML------QPREPDVS 250

Query: 383 LPQHIPAGCSLQFIFTWCLEIRAIPKKAFLRALVDYTSDSAEKRRLQELCSKQGAADYSR 442
            P  +P  CS++ + +  L+I ++P+++F   L   +    E+ +L E  S QG  +   
Sbjct: 251 SPTRLPQPCSMRHLVSHYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFE 310

Query: 443 FVRDACACLLDLLLAFP--SCQPPLSLLLEHLPKLQPRPYSCASSSLFHPGKLHFVFNIV 500
           +       +L++L  FP  +   P   LL+ +P ++PR +S ASS L HP +L  +  +V
Sbjct: 311 YCNRPRRTILEVLCDFPHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVV 370

Query: 501 EFLSTATTEVLRKGVCTGWLALLVASVLQPNIHASHEDSGKA-LAPKISISPRTTNSFHL 559
           +F +       R+G+C+ WLA L              D G+  +   + + P    S   
Sbjct: 371 QFQTRLKEP--RRGLCSSWLASL--------------DPGQGPVRVPLWVRP---GSLAF 411

Query: 560 PDDPSIPIIMVGPGTGIAPFIGFLQHREKLQEQHPDGNFGAMWLFFGCRHKDRDYLFRKE 619
           P+ P  P+IMVGPGTG+APF   +Q R     Q   GNF    LFFGCR +D+D+ +  E
Sbjct: 412 PETPDTPVIMVGPGTGVAPFRAAIQER---VAQGQTGNF----LFFGCRWRDQDFYWEAE 464

Query: 620 LRHFLKHGILTHLKVSFSRDAPVGEEEAPAKYVQDNIQLHGQQVARIL 667
            +   K   LT L  +FSR      E+    YVQ  ++  G  V  +L
Sbjct: 465 WQELEKRDCLT-LIPAFSR------EQEQKVYVQHRLRELGSLVWELL 505



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 40/130 (30%), Positives = 63/130 (48%), Gaps = 3/130 (2%)

Query: 30  RFLLLYATQQGQAKAIAEEICEQAVVHGFSADLHCISESDKYDLKTETAPLVVVV-STTG 88
           + L+L+ +Q G A+ ++E +  +A        +  +      +L  E  PLV+ V +TTG
Sbjct: 5   QLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINE--PLVIFVCATTG 62

Query: 89  TGDPPDTARKFVKEIQNQTLPVDFFAHLRYGLLGLGDSEYTYFCNGGKIIDKRLQELGAR 148
            GDPPD  + F + I  + LP      + + +LGLGDS Y  F    K + +RL +LG  
Sbjct: 63  QGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLGGS 122

Query: 149 HFYDTGHADD 158
                   DD
Sbjct: 123 ALLPVCLGDD 132


>gi|50726981 radical S-adenosyl methionine and flavodoxin domains 1
           [Homo sapiens]
          Length = 732

 Score = 46.6 bits (109), Expect = 8e-05
 Identities = 38/134 (28%), Positives = 57/134 (42%), Gaps = 9/134 (6%)

Query: 33  LLYATQQGQAKAIAEEICEQAVVHGFSADLHCISESDKYDLKTETAP----LVVVVSTTG 88
           + Y +Q G AK  A  + E          +  + E D  D   E        V +V+T  
Sbjct: 81  IFYGSQTGTAKGFATVLAEAVTSLDLPVAIINLKEYDPDDHLIEEVTSKNVCVFLVATYT 140

Query: 89  TGDPPDTARKFVKEIQNQTLPVDF----FAHLRYGLLGLGDSEY-TYFCNGGKIIDKRLQ 143
            G P ++A  F K ++  ++   F       +RY + GLG+S Y ++F   GK +DK L 
Sbjct: 141 DGLPTESAEWFCKWLEEASIDFRFGKTYLKGMRYAVFGLGNSAYASHFNKVGKNVDKWLW 200

Query: 144 ELGARHFYDTGHAD 157
            LGA      G  D
Sbjct: 201 MLGAHRVMSRGEGD 214


>gi|62241003 cardiomyopathy associated 5 [Homo sapiens]
          Length = 4069

 Score = 39.3 bits (90), Expect = 0.013
 Identities = 41/174 (23%), Positives = 75/174 (43%), Gaps = 20/174 (11%)

Query: 208  KSELLHIESQVELLRFDDSGRKDSEVLKQNAVNSNQSNVVIEDFESSLTRSVPPLSQASL 267
            K E LH E  V  L+  D+ +   E + + A   +++ V +  FE    R +  + +++ 
Sbjct: 3617 KMEFLH-EQMVHFLQSMDTAKDTLETIVREAEELDEA-VFLTSFEEINERLLSAM-ESTA 3673

Query: 268  NIPGLPPEYLQVHLQESLGQEESQVSVTSADPVFQVPISKAVQLTT---NDAIKTTLLVE 324
            ++  +P  +       SL +     S  S   + QV + +  +L     N A  TT+ V 
Sbjct: 3674 SLEKMPAAF-------SLFEHYDDSSARSDQMLKQVAVPQPPRLEPQEPNSATSTTIAVY 3726

Query: 325  LDISNTDFSYQPGDAFSVIC---PNSDSEVQSLLQRLQLEDKREHCVLLKIKAD 375
              ++  D      D+F V C   P  D EV  L++  +L  K  +C+   ++ D
Sbjct: 3727 WSMNKEDVI----DSFQVYCMEEPQDDQEVNELVEEYRLTVKESYCIFEDLEPD 3776


>gi|231571329 nitric oxide synthase 3 isoform 3 [Homo sapiens]
          Length = 614

 Score = 38.9 bits (89), Expect = 0.017
 Identities = 22/67 (32%), Positives = 38/67 (56%), Gaps = 2/67 (2%)

Query: 33  LLYATQQGQAKAIAEEICEQAVVHGFSADLHCISESDKYDLKTETAPLVVVVSTTGTGDP 92
           +LY ++ G+A++ A+++  +     F   + C+ E D   L+ ET  LVV  ST G GDP
Sbjct: 522 ILYGSETGRAQSYAQQL-GRLFRKAFDPRVLCMDEYDVVSLEHETLVLVVT-STFGNGDP 579

Query: 93  PDTARKF 99
           P+   ++
Sbjct: 580 PENGERW 586


>gi|231571356 nitric oxide synthase 3 isoform 4 [Homo sapiens]
          Length = 629

 Score = 37.7 bits (86), Expect = 0.038
 Identities = 22/62 (35%), Positives = 36/62 (58%), Gaps = 2/62 (3%)

Query: 33  LLYATQQGQAKAIAEEICEQAVVHGFSADLHCISESDKYDLKTETAPLVVVVSTTGTGDP 92
           +LY ++ G+A++ A+++  +     F   + C+ E D   L+ ET  LVV  ST G GDP
Sbjct: 522 ILYGSETGRAQSYAQQL-GRLFRKAFDPRVLCMDEYDVVSLEHETLVLVVT-STFGNGDP 579

Query: 93  PD 94
           P+
Sbjct: 580 PE 581


>gi|231571314 nitric oxide synthase 3 isoform 2 [Homo sapiens]
          Length = 596

 Score = 37.7 bits (86), Expect = 0.038
 Identities = 22/62 (35%), Positives = 36/62 (58%), Gaps = 2/62 (3%)

Query: 33  LLYATQQGQAKAIAEEICEQAVVHGFSADLHCISESDKYDLKTETAPLVVVVSTTGTGDP 92
           +LY ++ G+A++ A+++  +     F   + C+ E D   L+ ET  LVV  ST G GDP
Sbjct: 522 ILYGSETGRAQSYAQQL-GRLFRKAFDPRVLCMDEYDVVSLEHETLVLVVT-STFGNGDP 579

Query: 93  PD 94
           P+
Sbjct: 580 PE 581


>gi|55742678 glucocorticoid induced transcript 1 [Homo sapiens]
          Length = 547

 Score = 37.7 bits (86), Expect = 0.038
 Identities = 36/151 (23%), Positives = 67/151 (44%), Gaps = 27/151 (17%)

Query: 162 LELVVEPWIAGLWPA-LRKHFRSSR-----------GQEEISGALPVASPASSRTDLVKS 209
           L+ +  P++ G WP     H+ S              +E         S +    D +K 
Sbjct: 173 LDTITGPYLTGQWPRDPHVHYPSCMKDKATQTPSCWAEEGAEKRSHQRSASWGSADQLKE 232

Query: 210 ELLHIESQVELLRFDDSGRKDSEVLKQNAVNSNQSNVVIEDFESSLTRSVP-PLSQASL- 267
           ++  +  Q++  R   S R   E  +Q+ ++ N  ++ I   +++ +RSVP PLS  S+ 
Sbjct: 233 QIAKLRQQLQ--RSKQSSRHSKEKDRQSPLHGN--HITISHTQATGSRSVPMPLSNISVP 288

Query: 268 ---------NIPGLPPEYLQVHLQESLGQEE 289
                    N+ G+ PE  +V ++E+ G+EE
Sbjct: 289 KSSVSRVPCNVEGISPELEKVFIKENNGKEE 319


>gi|113722133 senataxin [Homo sapiens]
          Length = 2677

 Score = 34.3 bits (77), Expect = 0.42
 Identities = 24/95 (25%), Positives = 45/95 (47%), Gaps = 14/95 (14%)

Query: 224  DDSGRKDSEVLKQNAVNSNQSNVVIEDFESSLTRSVPPLSQASLNIPGLPPEYLQVHLQE 283
            +D  R  S V  +   ++N+ ++V  DF+S   R+  P S+              +    
Sbjct: 1171 EDPVRPSSSVRNEGQSDTNKRDLVGNDFKSIDRRTSTPNSR--------------IQRAT 1216

Query: 284  SLGQEESQVSVTSADPVFQVPISKAVQLTTNDAIK 318
            ++ Q++S    T  +P+ +VP+SK  + T +DA K
Sbjct: 1217 TVSQKKSSKLCTCTEPIRKVPVSKTPKKTHSDAKK 1251


>gi|116805344 proline rich, lacrimal 1 [Homo sapiens]
          Length = 248

 Score = 32.0 bits (71), Expect = 2.1
 Identities = 23/114 (20%), Positives = 41/114 (35%), Gaps = 5/114 (4%)

Query: 270 PGLPPEYLQVHLQESLGQEESQVSVTSADPVFQVPISKAVQLTTNDAIKTTLLVELDISN 329
           P  PP    + +   +   E Q+++T+AD             TT+ + K T+ +      
Sbjct: 122 PPFPPIPFFLAIYLPISNPEPQINITTADTTITTNPPTTATATTSTSTKPTMTISSSTVP 181

Query: 330 TDFSYQPGDAFSVICPNSDSEVQSLLQRLQLEDKREHCVLLKIKADTKKKGATL 383
              + +P  + S   P + +E        Q+   R H VLL           T+
Sbjct: 182 ISSTPEPATSISAATPAASTE-----NTTQILANRPHTVLLNATVQVTTSNQTI 230


>gi|8923900 cytidine monophospho-N-acetylneuraminic acid synthetase
           [Homo sapiens]
          Length = 434

 Score = 31.6 bits (70), Expect = 2.7
 Identities = 20/51 (39%), Positives = 31/51 (60%), Gaps = 7/51 (13%)

Query: 671 NGHIYVCGDAKN-MAKDVHDALVQIISKEVGV------EKLEAMKTLATLK 714
           NGHIYV GD K  ++ DV DA+   + K+ G+      E+  + +TL++LK
Sbjct: 288 NGHIYVSGDQKEIISYDVKDAIGISLLKKSGIEVRLISERACSKQTLSSLK 338


>gi|156416003 succinate dehydrogenase complex, subunit A,
           flavoprotein precursor [Homo sapiens]
          Length = 664

 Score = 31.2 bits (69), Expect = 3.5
 Identities = 23/104 (22%), Positives = 41/104 (39%)

Query: 259 VPPLSQASLNIPGLPPEYLQVHLQESLGQEESQVSVTSADPVFQVPISKAVQLTTNDAIK 318
           +P L     N+ G+P  Y    L+   GQ++    + +        +  A +L  N  + 
Sbjct: 400 IPVLPTVHYNMGGIPTNYKGQVLRHVNGQDQIVPGLYACGEAACASVHGANRLGANSLLD 459

Query: 319 TTLLVELDISNTDFSYQPGDAFSVICPNSDSEVQSLLQRLQLED 362
             +       + + S +PGD    I PN+  E    L +L+  D
Sbjct: 460 LVVFGRACALSIEESCRPGDKVPPIKPNAGEESVMNLDKLRFAD 503


>gi|153792230 hypothetical protein LOC57670 [Homo sapiens]
          Length = 1884

 Score = 31.2 bits (69), Expect = 3.5
 Identities = 17/51 (33%), Positives = 28/51 (54%)

Query: 235 KQNAVNSNQSNVVIEDFESSLTRSVPPLSQASLNIPGLPPEYLQVHLQESL 285
           K+ AVN ++ +  + D   +  R V P+   +++ PGLP E L+  L  SL
Sbjct: 98  KEVAVNDDEMDNFLPDTHWTTPRMVSPIQYITVSPPGLPREALEPMLTPSL 148


>gi|153251766 hypothetical protein LOC56181 isoform a [Homo sapiens]
          Length = 292

 Score = 30.4 bits (67), Expect = 6.0
 Identities = 35/132 (26%), Positives = 59/132 (44%), Gaps = 11/132 (8%)

Query: 185 RGQEEISGALPV-ASPASSRTDLVKSELLHIESQVELLRFDDSGRKDSEVLKQNAVNSNQ 243
           RG EE   AL   A PA SRT  ++ EL H+ SQ+  +   D+    S  L  + ++   
Sbjct: 108 RGSEERLLALKKPALPALSRTTELQDELSHLRSQIAKIVAADAA---SASLTPDFLSPGS 164

Query: 244 SNVVI------EDFESSLTRSVPPLS-QASLNIPGLPPEYLQVHLQESLGQEESQVSVTS 296
           SNV          F S+ +  +  ++ +  + +P LP   L         + E + + +S
Sbjct: 165 SNVSSPLPCFGSSFHSTTSFVISDITEETEVEVPELPSVPLLCSASPECCKPEHKAACSS 224

Query: 297 ADPVFQVPISKA 308
           ++    V +SKA
Sbjct: 225 SEEDDCVSLSKA 236


>gi|153251748 hypothetical protein LOC56181 isoform a [Homo sapiens]
          Length = 292

 Score = 30.4 bits (67), Expect = 6.0
 Identities = 35/132 (26%), Positives = 59/132 (44%), Gaps = 11/132 (8%)

Query: 185 RGQEEISGALPV-ASPASSRTDLVKSELLHIESQVELLRFDDSGRKDSEVLKQNAVNSNQ 243
           RG EE   AL   A PA SRT  ++ EL H+ SQ+  +   D+    S  L  + ++   
Sbjct: 108 RGSEERLLALKKPALPALSRTTELQDELSHLRSQIAKIVAADAA---SASLTPDFLSPGS 164

Query: 244 SNVVI------EDFESSLTRSVPPLS-QASLNIPGLPPEYLQVHLQESLGQEESQVSVTS 296
           SNV          F S+ +  +  ++ +  + +P LP   L         + E + + +S
Sbjct: 165 SNVSSPLPCFGSSFHSTTSFVISDITEETEVEVPELPSVPLLCSASPECCKPEHKAACSS 224

Query: 297 ADPVFQVPISKA 308
           ++    V +SKA
Sbjct: 225 SEEDDCVSLSKA 236


>gi|153251745 hypothetical protein LOC56181 isoform a [Homo sapiens]
          Length = 292

 Score = 30.4 bits (67), Expect = 6.0
 Identities = 35/132 (26%), Positives = 59/132 (44%), Gaps = 11/132 (8%)

Query: 185 RGQEEISGALPV-ASPASSRTDLVKSELLHIESQVELLRFDDSGRKDSEVLKQNAVNSNQ 243
           RG EE   AL   A PA SRT  ++ EL H+ SQ+  +   D+    S  L  + ++   
Sbjct: 108 RGSEERLLALKKPALPALSRTTELQDELSHLRSQIAKIVAADAA---SASLTPDFLSPGS 164

Query: 244 SNVVI------EDFESSLTRSVPPLS-QASLNIPGLPPEYLQVHLQESLGQEESQVSVTS 296
           SNV          F S+ +  +  ++ +  + +P LP   L         + E + + +S
Sbjct: 165 SNVSSPLPCFGSSFHSTTSFVISDITEETEVEVPELPSVPLLCSASPECCKPEHKAACSS 224

Query: 297 ADPVFQVPISKA 308
           ++    V +SKA
Sbjct: 225 SEEDDCVSLSKA 236


>gi|19923907 oxidoreductase NAD-binding domain containing 1 [Homo
           sapiens]
          Length = 312

 Score = 30.4 bits (67), Expect = 6.0
 Identities = 19/65 (29%), Positives = 34/65 (52%), Gaps = 5/65 (7%)

Query: 560 PDDPSIPIIMVGPGTGIAPFIGFLQH-REKLQEQHPDGN---FGAMWLFFGCRHKDRDYL 615
           P D S  ++++  G GI P +  L+H  + L+EQ    N    G + LF+  ++   + L
Sbjct: 165 PADASRNLVLIAGGVGINPLLSILRHAADLLREQANKRNGYEIGTIKLFYSAKNTS-ELL 223

Query: 616 FRKEL 620
           F+K +
Sbjct: 224 FKKNI 228


>gi|38569394 inhibitor of kappa light polypeptide gene enhancer in
            B-cells, kinase complex-associated protein [Homo sapiens]
          Length = 1332

 Score = 30.0 bits (66), Expect = 7.9
 Identities = 31/137 (22%), Positives = 49/137 (35%), Gaps = 18/137 (13%)

Query: 178  RKHFRSSRGQEEISGALPVASPASSRTDLVKSELLHIESQVELLRFDDSGRKDSEVLKQN 237
            +KH        E    L   S     T+ +K E+ HI   + L  FD+ GR         
Sbjct: 1203 KKHSLKEGSPLEDLALLEALSEVVQNTENLKDEVYHILKVLFLFEFDEQGR--------- 1253

Query: 238  AVNSNQSNVVIEDFESSLTRSVPPL----SQASLNIPGLPPEYLQVHLQESLGQEESQVS 293
                 +     ED    + RS+P +     Q +   P L P      +  S  Q+++ V 
Sbjct: 1254 -----ELQKAFEDTLQLMERSLPEIWTLTYQQNSATPVLGPNSTANSIMASYQQQKTSVP 1308

Query: 294  VTSADPVFQVPISKAVQ 310
            V  A+      I++  Q
Sbjct: 1309 VLDAELFIPPKINRRTQ 1325


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.135    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,204,608
Number of Sequences: 37866
Number of extensions: 1306410
Number of successful extensions: 3379
Number of sequences better than 10.0: 26
Number of HSP's better than 10.0 without gapping: 12
Number of HSP's successfully gapped in prelim test: 14
Number of HSP's that attempted gapping in prelim test: 3298
Number of HSP's gapped (non-prelim): 41
length of query: 725
length of database: 18,247,518
effective HSP length: 110
effective length of query: 615
effective length of database: 14,082,258
effective search space: 8660588670
effective search space used: 8660588670
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.