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Search of human proteins with 16933530
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|16933530 cytochrome P450, family 26, subfamily A,
polypeptide 1 isoform 1 [Homo sapiens]
(497 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|16933530 cytochrome P450, family 26, subfamily A, polypeptide... 1011 0.0
gi|16933528 cytochrome P450, family 26, subfamily A, polypeptide... 872 0.0
gi|9845285 cytochrome P450, family 26, subfamily b, polypeptide ... 401 e-112
gi|62952502 cytochrome P450, family 26, subfamily C, polypeptide... 393 e-109
gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide... 122 6e-28
gi|4503243 cytochrome P450, family 51, subfamily A, polypeptide ... 116 5e-26
gi|158937242 cytochrome P450, family 4, subfamily A, polypeptide... 110 4e-24
gi|62952506 cytochrome P450, family 4, subfamily A, polypeptide ... 109 5e-24
gi|225903399 cytochrome P450, family 51, subfamily A, polypeptid... 103 4e-22
gi|119220562 cytochrome P450, family 4, subfamily F, polypeptide... 102 1e-21
gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide ... 100 5e-21
gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11... 100 5e-21
gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11... 100 5e-21
gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7... 98 2e-20
gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide ... 97 3e-20
gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide... 97 3e-20
gi|158138530 cytochrome P450, family 4, subfamily F, polypeptide... 96 1e-19
gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide ... 95 1e-19
gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide ... 95 1e-19
gi|5729796 cytochrome P450, family 46 [Homo sapiens] 95 1e-19
gi|29837648 cytochrome P450, family 4, subfamily X, polypeptide ... 95 1e-19
gi|153218660 cytochrome P450, family 4, subfamily B, polypeptide... 94 3e-19
gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5... 92 8e-19
gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8... 92 1e-18
gi|153218662 cytochrome P450, family 4, subfamily B, polypeptide... 91 2e-18
gi|30023836 cytochrome P450 4Z1 [Homo sapiens] 91 3e-18
gi|13449277 cytochrome P450, family 2, subfamily S, polypeptide ... 87 5e-17
gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1 ... 86 1e-16
gi|167466231 cytochrome P450, family 27, subfamily C, polypeptid... 86 1e-16
gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide ... 81 3e-15
>gi|16933530 cytochrome P450, family 26, subfamily A, polypeptide 1
isoform 1 [Homo sapiens]
Length = 497
Score = 1011 bits (2613), Expect = 0.0
Identities = 497/497 (100%), Positives = 497/497 (100%)
Query: 1 MGLPALLASALCTFVLPLLLFLAAIKLWDLYCVSGRDRSCALPLPPGTMGFPFFGETLQM 60
MGLPALLASALCTFVLPLLLFLAAIKLWDLYCVSGRDRSCALPLPPGTMGFPFFGETLQM
Sbjct: 1 MGLPALLASALCTFVLPLLLFLAAIKLWDLYCVSGRDRSCALPLPPGTMGFPFFGETLQM 60
Query: 61 VLQRRKFLQMKRRKYGFIYKTHLFGRPTVRVMGADNVRRILLGEHRLVSVHWPASVRTIL 120
VLQRRKFLQMKRRKYGFIYKTHLFGRPTVRVMGADNVRRILLGEHRLVSVHWPASVRTIL
Sbjct: 61 VLQRRKFLQMKRRKYGFIYKTHLFGRPTVRVMGADNVRRILLGEHRLVSVHWPASVRTIL 120
Query: 121 GSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEVGSSLEQWLSCGERGLLVYPE 180
GSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEVGSSLEQWLSCGERGLLVYPE
Sbjct: 121 GSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEVGSSLEQWLSCGERGLLVYPE 180
Query: 181 VKRLMFRIAMRILLGCEPQLAGDGDSEQQLVEAFEEMTRNLFSLPIDVPFSGLYRGMKAR 240
VKRLMFRIAMRILLGCEPQLAGDGDSEQQLVEAFEEMTRNLFSLPIDVPFSGLYRGMKAR
Sbjct: 181 VKRLMFRIAMRILLGCEPQLAGDGDSEQQLVEAFEEMTRNLFSLPIDVPFSGLYRGMKAR 240
Query: 241 NLIHARIEQNIRAKICGLRASEAGQGCKDALQLLIEHSWERGERLDMQALKQSSTELLFG 300
NLIHARIEQNIRAKICGLRASEAGQGCKDALQLLIEHSWERGERLDMQALKQSSTELLFG
Sbjct: 241 NLIHARIEQNIRAKICGLRASEAGQGCKDALQLLIEHSWERGERLDMQALKQSSTELLFG 300
Query: 301 GHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVI 360
GHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVI
Sbjct: 301 GHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVI 360
Query: 361 KETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFM 420
KETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFM
Sbjct: 361 KETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFM 420
Query: 421 LPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLLNGPPTMKTSPTV 480
LPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLLNGPPTMKTSPTV
Sbjct: 421 LPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLLNGPPTMKTSPTV 480
Query: 481 YPVDNLPARFTHFHGEI 497
YPVDNLPARFTHFHGEI
Sbjct: 481 YPVDNLPARFTHFHGEI 497
>gi|16933528 cytochrome P450, family 26, subfamily A, polypeptide 1
isoform 2 [Homo sapiens]
Length = 428
Score = 872 bits (2252), Expect = 0.0
Identities = 428/428 (100%), Positives = 428/428 (100%)
Query: 70 MKRRKYGFIYKTHLFGRPTVRVMGADNVRRILLGEHRLVSVHWPASVRTILGSGCLSNLH 129
MKRRKYGFIYKTHLFGRPTVRVMGADNVRRILLGEHRLVSVHWPASVRTILGSGCLSNLH
Sbjct: 1 MKRRKYGFIYKTHLFGRPTVRVMGADNVRRILLGEHRLVSVHWPASVRTILGSGCLSNLH 60
Query: 130 DSSHKQRKKVIMRAFSREALECYVPVITEEVGSSLEQWLSCGERGLLVYPEVKRLMFRIA 189
DSSHKQRKKVIMRAFSREALECYVPVITEEVGSSLEQWLSCGERGLLVYPEVKRLMFRIA
Sbjct: 61 DSSHKQRKKVIMRAFSREALECYVPVITEEVGSSLEQWLSCGERGLLVYPEVKRLMFRIA 120
Query: 190 MRILLGCEPQLAGDGDSEQQLVEAFEEMTRNLFSLPIDVPFSGLYRGMKARNLIHARIEQ 249
MRILLGCEPQLAGDGDSEQQLVEAFEEMTRNLFSLPIDVPFSGLYRGMKARNLIHARIEQ
Sbjct: 121 MRILLGCEPQLAGDGDSEQQLVEAFEEMTRNLFSLPIDVPFSGLYRGMKARNLIHARIEQ 180
Query: 250 NIRAKICGLRASEAGQGCKDALQLLIEHSWERGERLDMQALKQSSTELLFGGHETTASAA 309
NIRAKICGLRASEAGQGCKDALQLLIEHSWERGERLDMQALKQSSTELLFGGHETTASAA
Sbjct: 181 NIRAKICGLRASEAGQGCKDALQLLIEHSWERGERLDMQALKQSSTELLFGGHETTASAA 240
Query: 310 TSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVIKETLRLNPP 369
TSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVIKETLRLNPP
Sbjct: 241 TSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVIKETLRLNPP 300
Query: 370 VPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPEDASR 429
VPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPEDASR
Sbjct: 301 VPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPEDASR 360
Query: 430 FSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLLNGPPTMKTSPTVYPVDNLPAR 489
FSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLLNGPPTMKTSPTVYPVDNLPAR
Sbjct: 361 FSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLLNGPPTMKTSPTVYPVDNLPAR 420
Query: 490 FTHFHGEI 497
FTHFHGEI
Sbjct: 421 FTHFHGEI 428
>gi|9845285 cytochrome P450, family 26, subfamily b, polypeptide 1
[Homo sapiens]
Length = 512
Score = 401 bits (1031), Expect = e-112
Identities = 216/494 (43%), Positives = 306/494 (61%), Gaps = 13/494 (2%)
Query: 1 MGLPALLASALCTFVLPLLLFLAAIKLWDLYCVSGRDRSCALPLPPGTMGFPFFGETLQM 60
+ L + LA+ V LL + +LW L + RD+SC LP+P G+MGFP GET
Sbjct: 6 LDLVSALATLAACLVSVTLLLAVSQQLWQLRWAATRDKSCKLPIPKGSMGFPLIGETGHW 65
Query: 61 VLQRRKFLQMKRRKYGFIYKTHLFGRPTVRVMGADNVRRILLGEHRLVSVHWPASVRTIL 120
+LQ F +R KYG ++KTHL GRP +RV GA+NVR+IL+GEH LVS WP S R +L
Sbjct: 66 LLQGSGFQSSRREKYGNVFKTHLLGRPLIRVTGAENVRKILMGEHHLVSTEWPRSTRMLL 125
Query: 121 GSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEVGSSLEQWLSCGERGLLVYPE 180
G +SN H+ ++KV + FS EALE Y+P I + +L W S E + VY E
Sbjct: 126 GPNTVSNSIGDIHRNKRKVFSKIFSHEALESYLPKIQLVIQDTLRAWSSHPE-AINVYQE 184
Query: 181 VKRLMFRIAMRILLGCEPQLAGDGDSEQQLVEAFEEMTRNLFSLPIDVPFSGLYRGMKAR 240
++L FR+A+R+LLG + + L E +++ N+FSLP+D+PFSG RG++AR
Sbjct: 185 AQKLTFRMAIRVLLG----FSIPEEDLGHLFEVYQQFVDNVFSLPVDLPFSGYRRGIQAR 240
Query: 241 NLIHARIEQNIRAKICGLRASEAGQGCKDALQLLIEHSWERGERLDMQALKQSSTELLFG 300
++ +E+ IR K+ G+ DAL LLIE S E G+ + MQ LK + EL+F
Sbjct: 241 QILQKGLEKAIREKL----QCTQGKDYLDALDLLIESSKEHGKEMTMQELKDGTLELIFA 296
Query: 301 GHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSN--QDNKLDMEILEQLKYIGC 358
+ TTASA+TSLI L +P VL+K+R+EL++ G+L + L ++ L L+Y+ C
Sbjct: 297 AYATTASASTSLIMQLLKHPTVLEKLRDELRAHGILHSGGCPCEGTLRLDTLSGLRYLDC 356
Query: 359 VIKETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDR 418
VIKE +RL P+ GG+R L+TFEL+G+QIPKGW+V+YSI DTHD A +F + F+PDR
Sbjct: 357 VIKEVMRLFTPISGGYRTVLQTFELDGFQIPKGWSVMYSIRDTHDTAPVFKDVNVFDPDR 416
Query: 419 FMLPHPEDA-SRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLLNGP-PTMKT 476
F ED RF ++PFGGG+R+C+GK AK+ LK+ VELA ++L P +
Sbjct: 417 FSQARSEDKDGRFHYLPFGGGVRTCLGKHLAKLFLKVLAVELASTSRFELATRTFPRITL 476
Query: 477 SPTVYPVDNLPARF 490
P ++PVD L +F
Sbjct: 477 VPVLHPVDGLSVKF 490
>gi|62952502 cytochrome P450, family 26, subfamily C, polypeptide 1
[Homo sapiens]
Length = 522
Score = 393 bits (1010), Expect = e-109
Identities = 226/506 (44%), Positives = 305/506 (60%), Gaps = 35/506 (6%)
Query: 5 ALLASALCTFVLPLLLFLAAIKLWDLYCVSGRDRSCALPLPPGTMGFPFFGETLQMVLQR 64
++L +A + LL A LW L + RDR+ LPLP G+MG+PFFGETL ++Q
Sbjct: 10 SVLGAAGTALLCAGLLLSLAQHLWTLRWMLSRDRASTLPLPKGSMGWPFFGETLHWLVQG 69
Query: 65 RKFLQMKRRKYGFIYKTHLFGRPTVRVMGADNVRRILLGEHRLVSVHWPASVRTILGSGC 124
+F +R +YG ++KTHL GRP +RV GA+NVR ILLGEHRLV WP S +LGS
Sbjct: 70 SRFHSSRRERYGTVFKTHLLGRPVIRVSGAENVRTILLGEHRLVRSQWPQSAHILLGSHT 129
Query: 125 LSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEVGSSLEQWLSCGERGLLVYPEVKRL 184
L H++R+KV+ R FSR ALE YVP + + + W + G + VY K L
Sbjct: 130 LLGAVGEPHRRRRKVLARVFSRAALERYVPRLQGALRHEVRSWCAAG-GPVSVYDASKAL 188
Query: 185 MFRIAMRILLGCEPQLAGDGDSEQQLVEAFEEMTRNLFSLPIDVPFSGLYRGMKARNLIH 244
FR+A RILLG L D L FE++ NLFSLP+DVPFSGL +G++AR+ +H
Sbjct: 189 TFRMAARILLG----LRLDEAQCATLARTFEQLVENLFSLPLDVPFSGLRKGIRARDQLH 244
Query: 245 ARIEQNIRAKICGLRASEAGQGCKDALQLLIEHSWERGERLDMQALKQSSTELLFGGHET 304
+E I K+ +A+E G DAL L+I + E G MQ LK+S+ ELLF T
Sbjct: 245 RHLEGAISEKLHEDKAAEPG----DALDLIIHSARELGHEPSMQELKESAVELLFAAFFT 300
Query: 305 TASAATSLITYLGLYPHVLQKVREELKSKGL-------------------LCKSNQDNKL 345
TASA+TSL+ L +P + K+REEL ++GL C D L
Sbjct: 301 TASASTSLVLLLLQHPAAIAKIREELVAQGLGRACGCAPGAAGGSEGPPPDCGCEPD--L 358
Query: 346 DMEILEQLKYIGCVIKETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVA 405
+ L +L+Y+ CV+KE LRL PPV GG+R AL+TFEL+GYQIPKGW+V+YSI DTH+ A
Sbjct: 359 SLAALGRLRYVDCVVKEVLRLLPPVSGGYRTALRTFELDGYQIPKGWSVMYSIRDTHETA 418
Query: 406 EIFTNKEE-FNPDRFMLPHPED---ASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELAR 461
++ + E F+P+RF + +SRF +IPFGGG RSC+G+E A+ +L++ VEL R
Sbjct: 419 AVYRSPPEGFDPERFGAAREDSRGASSRFHYIPFGGGARSCLGQELAQAVLQLLAVELVR 478
Query: 462 HCDWQLLNGP-PTMKTSPTVYPVDNL 486
W+L P M+T P V+PVD L
Sbjct: 479 TARWELATPAFPAMQTVPIVHPVDGL 504
>gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide 2
[Homo sapiens]
Length = 525
Score = 122 bits (307), Expect = 6e-28
Identities = 114/454 (25%), Positives = 194/454 (42%), Gaps = 49/454 (10%)
Query: 43 PLPPGTMGFPFFGETLQMVLQRRKFLQM-----KRRKYGFIYKTHLFGRPTVRVMGADNV 97
P+P +P G L M R+F Q + ++ + K + P V + A+NV
Sbjct: 49 PIPTVARAYPLVGHALLMKPDGREFFQQIIEYTEEYRHMPLLKLWVGPVPMVALYNAENV 108
Query: 98 RRILLGEHRLVSVHWPASVRTILGSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVIT 157
IL ++ + LG G L++ + + R+K++ F LE ++ ++
Sbjct: 109 EVILTSSKQIDKSSMYKFLEPWLGLGLLTST-GNKWRSRRKMLTPTFHFTILEDFLDIMN 167
Query: 158 EEVG---SSLEQWLSCGERGLLVYPEVKRLMFRIAMRIL-LGCEP----QLAGDGDSEQQ 209
E+ LE+ ++ E F I + L + CE + + + +
Sbjct: 168 EQANILVKKLEKHIN---------QEAFNCFFYITLCALDIICETAMGKNIGAQSNDDSE 218
Query: 210 LVEAFEEMTRNLFSLPIDVPFSGL----------YRGMKARNLIHARIEQNIRAKICGLR 259
V A M+ +F I +P+ L + K+ ++H I + +
Sbjct: 219 YVRAVYRMSEMIFRR-IKMPWLWLDLWYLMFKEGWEHKKSLQILHTFTNSVIAERANEMN 277
Query: 260 ASE--AGQGCKDA---------LQLLIEHSWERGERLDMQALKQSSTELLFGGHETTASA 308
A+E G G A L LL+ + + G RL + +++ +F GH+TTA+A
Sbjct: 278 ANEDCRGDGRGSAPSKNKRRAFLDLLLSVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAA 337
Query: 309 ATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVIKETLRLNP 368
+ LG P V +KV EL D +E L++L+Y+ CVIKETLRL P
Sbjct: 338 INWSLYLLGSNPEVQKKVDHELDD----VFGKSDRPATVEDLKKLRYLECVIKETLRLFP 393
Query: 369 PVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPEDAS 428
VP R + E+ GY++ KG + H F N EEF P+RF + +
Sbjct: 394 SVPLFARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENAQGRH 453
Query: 429 RFSFIPFGGGLRSCVGKEFAKILLKIFTVELARH 462
++++PF G R+C+G++FA + K + RH
Sbjct: 454 PYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRH 487
>gi|4503243 cytochrome P450, family 51, subfamily A, polypeptide 1
isoform 1 [Homo sapiens]
Length = 509
Score = 116 bits (290), Expect = 5e-26
Identities = 114/492 (23%), Positives = 208/492 (42%), Gaps = 24/492 (4%)
Query: 3 LPALLASALCTFVLPLLLFLAAIKLWDLYCVSGRDRSCALPLPPGTMG-FPFFGETLQMV 61
L LL + T L L+ LAA L L + PP PF G +
Sbjct: 33 LSMLLIACAFTLSLVYLIRLAAGHLVQL--------PAGVKSPPYIFSPIPFLGHAIAFG 84
Query: 62 LQRRKFLQMKRRKYGFIYKTHLFGRPTVRVMGADNVRRILLGEHRLVSVHWPASVRT--I 119
+FL+ KYG ++ + G+ ++G+D + ++ ++ S T +
Sbjct: 85 KSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNEDLNAEDVYSRLTTPV 144
Query: 120 LGSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEVGSSLEQWLSCGERGLLVYP 179
G G ++ + ++KK++ + + +V +I +E E W GE+ V+
Sbjct: 145 FGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKETKEYFESWGESGEKN--VFE 202
Query: 180 EVKRLMFRIAMRILLGCEPQLAGDGDSEQQLVEAFEEMTRNLFSLPIDVPFSGLYRGMKA 239
+ L+ A L G E + + Q + + + LP +P R
Sbjct: 203 ALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFRR---- 258
Query: 240 RNLIHARIEQNIRAKICGLRASEAGQGCKDALQLLIEHSWERGERLDMQALKQSSTELLF 299
R+ H I+ I R S+ + D LQ L++ +++ G L + LL
Sbjct: 259 RDRAHREIKDIFYKAIQKRRQSQ--EKIDDILQTLLDATYKDGRPLTDDEVAGMLIGLLL 316
Query: 300 GGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCV 359
G T+++ + + +L + +K E K+ +C N L + L+ L +
Sbjct: 317 AGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKT---VCGENLP-PLTYDQLKDLNLLDRC 372
Query: 360 IKETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRF 419
IKETLRL PP+ R+A + GY IP G V S + + + + +FNPDR+
Sbjct: 373 IKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRY 432
Query: 420 MLPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLLNGP-PTMKTSP 478
+ +P +F+++PFG G C+G+ FA + +K + R ++ L++G PT+ +
Sbjct: 433 LQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDGYFPTVNYTT 492
Query: 479 TVYPVDNLPARF 490
++ +N R+
Sbjct: 493 MIHTPENPVIRY 504
>gi|158937242 cytochrome P450, family 4, subfamily A, polypeptide 11
[Homo sapiens]
Length = 519
Score = 110 bits (274), Expect = 4e-24
Identities = 101/355 (28%), Positives = 165/355 (46%), Gaps = 28/355 (7%)
Query: 120 LGSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEVGSSLEQW--LSCGERGLLV 177
+G G L L+ + Q ++++ AF + L+ YV ++ + V L++W L + L V
Sbjct: 127 IGYGLLL-LNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEV 185
Query: 178 YPEVKRLMFRIAMRILLGCEPQLAGDGDSEQQLVEAFEEMTRNLFSL------PIDVPFS 231
+ V + M+ + + D +S Q ++A ++ +FS D +S
Sbjct: 186 FQHVSLMTLDTIMKCAFSHQGSIQVDRNS-QSYIQAISDLNNLVFSRVRNAFHQNDTIYS 244
Query: 232 GLYRGM---KARNLIHARIEQNIRAKICGLRASEAGQGCK-----DALQLLIEHSWERGE 283
G +A L H +Q I+ + L+ + K D L +L+ E G
Sbjct: 245 LTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGS 304
Query: 284 RLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDN 343
L + L+ +F GH+TTAS + ++ L +P ++ REE+ S LL
Sbjct: 305 ILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHS--LL---GDGA 359
Query: 344 KLDMEILEQLKYIGCVIKETLRLNPPVPG-GFRVALKTFELNGYQIPKGWNVIYSICDTH 402
+ L+Q+ Y IKE LRL PPVPG G ++ +G +PKG V+ SI H
Sbjct: 360 SITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLH 419
Query: 403 DVAEIFTNKEEFNPDRFMLPHPEDASR-FSFIPFGGGLRSCVGKEFAKILLKIFT 456
+++ N E F+P RF P A +F+PF GG R+C+GK+FA LK+ T
Sbjct: 420 HNPKVWPNPEVFDPFRFA---PGSAQHSHAFLPFSGGSRNCIGKQFAMNELKVAT 471
>gi|62952506 cytochrome P450, family 4, subfamily A, polypeptide 22
[Homo sapiens]
Length = 519
Score = 109 bits (273), Expect = 5e-24
Identities = 101/354 (28%), Positives = 164/354 (46%), Gaps = 30/354 (8%)
Query: 120 LGSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEVGSSLEQW--LSCGERGLLV 177
+G G L L+ + Q ++++ AF + L+ YV ++ + V L++W L + L V
Sbjct: 127 IGYGLLL-LNGQTWFQHRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQDSPLEV 185
Query: 178 YPEVKRLMFRIAMRILLGCEPQLAGDGDSEQQLVEAFEEMT-------RNLFSLPIDVPF 230
+ V + M+ + + D +S Q ++A ++ RN F D +
Sbjct: 186 FQHVSLMTLDTIMKSAFSHQGSIQVDRNS-QSYIQAISDLNSLVFCCMRNAFH-ENDTIY 243
Query: 231 SGLYRGM---KARNLIHARIEQNIRAKICGLRASEAGQGCK-----DALQLLIEHSWERG 282
S G +A L H +Q I+ + L+ + K D L +L+ E G
Sbjct: 244 SLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKMENG 303
Query: 283 ERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQD 342
L + L+ +F GH+TTAS + ++ L +P ++ REE+ GLL
Sbjct: 304 SILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEI--HGLL---GDG 358
Query: 343 NKLDMEILEQLKYIGCVIKETLRLNPPVPG-GFRVALKTFELNGYQIPKGWNVIYSICDT 401
+ L+Q+ Y IKE LRL PPVPG G ++ +G +PKG V+ SI
Sbjct: 359 ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGL 418
Query: 402 HDVAEIFTNKEEFNPDRFMLPHPEDASR-FSFIPFGGGLRSCVGKEFAKILLKI 454
H +++ N E F+P RF P A +F+PF GG R+C+GK+FA LK+
Sbjct: 419 HHNPKVWPNLEVFDPSRFA---PGSAQHSHAFLPFSGGSRNCIGKQFAMNQLKV 469
>gi|225903399 cytochrome P450, family 51, subfamily A, polypeptide 1
isoform 2 [Homo sapiens]
Length = 404
Score = 103 bits (257), Expect = 4e-22
Identities = 88/373 (23%), Positives = 164/373 (43%), Gaps = 13/373 (3%)
Query: 119 ILGSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEVGSSLEQWLSCGERGLLVY 178
+ G G ++ + ++KK++ + + +V +I +E E W GE+ V+
Sbjct: 39 VFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKETKEYFESWGESGEKN--VF 96
Query: 179 PEVKRLMFRIAMRILLGCEPQLAGDGDSEQQLVEAFEEMTRNLFSLPIDVPFSGLYRGMK 238
+ L+ A L G E + + Q + + + LP +P R
Sbjct: 97 EALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFRR--- 153
Query: 239 ARNLIHARIEQNIRAKICGLRASEAGQGCKDALQLLIEHSWERGERLDMQALKQSSTELL 298
R+ H I+ I R S+ + D LQ L++ +++ G L + LL
Sbjct: 154 -RDRAHREIKDIFYKAIQKRRQSQ--EKIDDILQTLLDATYKDGRPLTDDEVAGMLIGLL 210
Query: 299 FGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGC 358
G T+++ + + +L + +K E K+ +C N L + L+ L +
Sbjct: 211 LAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKT---VCGENLP-PLTYDQLKDLNLLDR 266
Query: 359 VIKETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDR 418
IKETLRL PP+ R+A + GY IP G V S + + + + +FNPDR
Sbjct: 267 CIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDR 326
Query: 419 FMLPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLLNGP-PTMKTS 477
++ +P +F+++PFG G C+G+ FA + +K + R ++ L++G PT+ +
Sbjct: 327 YLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDGYFPTVNYT 386
Query: 478 PTVYPVDNLPARF 490
++ +N R+
Sbjct: 387 TMIHTPENPVIRY 399
>gi|119220562 cytochrome P450, family 4, subfamily F, polypeptide 3
[Homo sapiens]
Length = 520
Score = 102 bits (253), Expect = 1e-21
Identities = 57/187 (30%), Positives = 105/187 (56%), Gaps = 4/187 (2%)
Query: 269 DALQLLIEHSWERGERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVRE 328
D + +L+ E G++L + ++ + +F GH+TTAS + ++ +L +P ++ R+
Sbjct: 297 DFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQ 356
Query: 329 ELKSKGLLCKSNQDNKLDMEILEQLKYIGCVIKETLRLNPPVPGGFRVALKTFEL-NGYQ 387
E++ L K + +++ + L QL ++ IKE+LRL+PPVP R + L +G
Sbjct: 357 EVQE---LLKDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRV 413
Query: 388 IPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPEDASRFSFIPFGGGLRSCVGKEF 447
IPKG + S+ TH ++ + E ++P RF + ++ S +FIPF G R+C+G+ F
Sbjct: 414 IPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPKNIKERSPLAFIPFSAGPRNCIGQAF 473
Query: 448 AKILLKI 454
A +K+
Sbjct: 474 AMAEMKV 480
>gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide 43
isoform 2 [Homo sapiens]
Length = 503
Score = 99.8 bits (247), Expect = 5e-21
Identities = 111/462 (24%), Positives = 198/462 (42%), Gaps = 39/462 (8%)
Query: 46 PGTMGFPFFGETLQMVLQRRKFLQMKRRKYGFIYKTHLFGRPTVRVMGADNVRRILLGE- 104
PG PF G L + F + KYG ++ + +P + +M D ++ +L+ E
Sbjct: 39 PGPTPLPFLGTILFYLRGLWNFDRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKEC 98
Query: 105 HRLVSVHWPASVRTILGSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEVGSSL 164
+ + + P L S LS D K+ + ++ AF+ + VP+I++ +
Sbjct: 99 YSVFTNQMPLGPMGFLKSA-LSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLV 157
Query: 165 EQWLSCGERGLLVYPEVKRLMFRIAMRILLGC----------EPQLAGDGDSEQQLVEAF 214
E + +K M ++ G PQ + ++ L F
Sbjct: 158 RSLRQEAENSKSI--NLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDF 215
Query: 215 EEMTRNLFSL-PIDVP-FSGLYRGMKARNLIHARIEQNIRAKICGLRASEAGQGCKDALQ 272
+ L SL P P F L G+ +++ H R K L+ + + D Q
Sbjct: 216 LDPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLKNSIERMKESRLKDKQKHR--VDFFQ 273
Query: 273 LLIEHSWERGERL-----DMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVR 327
+I+ + + D++ + QS ++F ++TT++ ++ L +P V QK++
Sbjct: 274 QMIDSQNSKETKSHKALSDLELVAQSII-IIFAAYDTTSTTLPFIMYELATHPDVQQKLQ 332
Query: 328 EELKSKGLLCKSNQDNKLDM--EILEQLKYIGCVIKETLRLNPPVPGGFRVALKTFELNG 385
EE+ + NK + + L Q++Y+ V+ ETLRL P V RV K E+NG
Sbjct: 333 EEIDAV-------LPNKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEING 385
Query: 386 YQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPEDASRFSFIPFGGGLRSCVGK 445
IPKG V+ I H + +T E+F P+RF + + + +IPFG G R+C+G
Sbjct: 386 VFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRNCIGM 445
Query: 446 EFAKILLKIFTVELARHCDWQLLNGPPTMKTSPTVYPVDNLP 487
FA +K+ + ++ ++ K + +DNLP
Sbjct: 446 RFALTNIKLAVIRALQNFSFK------PCKETQIPLKLDNLP 481
>gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11
[Homo sapiens]
Length = 524
Score = 99.8 bits (247), Expect = 5e-21
Identities = 85/353 (24%), Positives = 159/353 (45%), Gaps = 22/353 (6%)
Query: 120 LGSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEVGSSLEQWLSCGERG---LL 176
LG G L + D + R+ ++ AF L+ Y+ + + V ++W G L
Sbjct: 132 LGDGLLLSGGDKWSRHRR-MLTPAFHFNILKPYMKIFNKSVNIMHDKWQRLASEGSARLD 190
Query: 177 VYPEVKRLMFRIAMRILLGCEPQLAGDGDSEQQLV---EAFEEMTRNLFSLPIDVPFSGL 233
++ + + + + E + AF E L D +
Sbjct: 191 MFEHISLMTLDSLQKCVFSFESNCQEKPSEYIAAILELSAFVEKRNQQILLHTDFLYYLT 250
Query: 234 YRGMKAR---NLIHARIEQNIRAKICGLRA--------SEAGQGCKDALQLLIEHSWERG 282
G + R +L+H + I+ + C L ++A D + +L+ E G
Sbjct: 251 PDGQRFRRACHLVHDFTDAVIQERRCTLPTQGIDDFLKNKAKSKTLDFIDVLLLSKDEDG 310
Query: 283 ERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQD 342
+ L + ++ + +F GH+TTAS + ++ +L +P ++ R+E++ L K +
Sbjct: 311 KELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQE---LLKDREP 367
Query: 343 NKLDMEILEQLKYIGCVIKETLRLNPPVPGGFRVALKTFEL-NGYQIPKGWNVIYSICDT 401
+++ + L QL ++ IKE+LRL+PPVP R + F L +G IPKG + +I
Sbjct: 368 IEIEWDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVCLINIIGI 427
Query: 402 HDVAEIFTNKEEFNPDRFMLPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKI 454
H ++ + E ++P RF + ++ S +FIPF G R+C+G+ FA +K+
Sbjct: 428 HYNPTVWPDPEVYDPFRFDQENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKV 480
>gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11
[Homo sapiens]
Length = 524
Score = 99.8 bits (247), Expect = 5e-21
Identities = 85/353 (24%), Positives = 159/353 (45%), Gaps = 22/353 (6%)
Query: 120 LGSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEVGSSLEQWLSCGERG---LL 176
LG G L + D + R+ ++ AF L+ Y+ + + V ++W G L
Sbjct: 132 LGDGLLLSGGDKWSRHRR-MLTPAFHFNILKPYMKIFNKSVNIMHDKWQRLASEGSARLD 190
Query: 177 VYPEVKRLMFRIAMRILLGCEPQLAGDGDSEQQLV---EAFEEMTRNLFSLPIDVPFSGL 233
++ + + + + E + AF E L D +
Sbjct: 191 MFEHISLMTLDSLQKCVFSFESNCQEKPSEYIAAILELSAFVEKRNQQILLHTDFLYYLT 250
Query: 234 YRGMKAR---NLIHARIEQNIRAKICGLRA--------SEAGQGCKDALQLLIEHSWERG 282
G + R +L+H + I+ + C L ++A D + +L+ E G
Sbjct: 251 PDGQRFRRACHLVHDFTDAVIQERRCTLPTQGIDDFLKNKAKSKTLDFIDVLLLSKDEDG 310
Query: 283 ERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQD 342
+ L + ++ + +F GH+TTAS + ++ +L +P ++ R+E++ L K +
Sbjct: 311 KELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQE---LLKDREP 367
Query: 343 NKLDMEILEQLKYIGCVIKETLRLNPPVPGGFRVALKTFEL-NGYQIPKGWNVIYSICDT 401
+++ + L QL ++ IKE+LRL+PPVP R + F L +G IPKG + +I
Sbjct: 368 IEIEWDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVCLINIIGI 427
Query: 402 HDVAEIFTNKEEFNPDRFMLPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKI 454
H ++ + E ++P RF + ++ S +FIPF G R+C+G+ FA +K+
Sbjct: 428 HYNPTVWPDPEVYDPFRFDQENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKV 480
>gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7
[Homo sapiens]
Length = 503
Score = 98.2 bits (243), Expect = 2e-20
Identities = 113/461 (24%), Positives = 199/461 (43%), Gaps = 32/461 (6%)
Query: 22 LAAIKLWDLYCVSGRDRSCALPLP-PGTMGFPFFGETLQMVLQRRKFLQMKRRKYGFIYK 80
L A+ L LY R L PG PF G L F +KY ++
Sbjct: 14 LLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKGYWTFDMECYKKYRKVWG 73
Query: 81 THLFGRPTVRVMGADNVRRILLGEHRLVSVHWPASVRTILGSGCLSNLHDSSHKQRKKVI 140
+ +P + + D ++ +L+ E V + +S D K+ + ++
Sbjct: 74 IYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNAISIAEDEEWKRIRSLL 133
Query: 141 MRAFSREALECYVPVITEEVGSSLEQWLSCGERGLLVYPEVKRLMFRIAMRILLGCEPQL 200
F+ L+ VP+I + + E G V +K + +M ++ +
Sbjct: 134 SPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPV--TLKHVFGAYSMDVITSTSFGV 191
Query: 201 AGDGDSEQQLVEAFEEMTRNL--------FSLPIDVPFSGLYRGMKARNL------IHAR 246
+ D + Q + F E T+ L F L I V F L ++A N+ + +
Sbjct: 192 SIDSLNNPQ--DPFVENTKKLLRFNPLDPFVLSIKV-FPFLTPILEALNITVFPRKVISF 248
Query: 247 IEQNIRAKICGLRASEAGQGCKDALQLLIEHSWERGERL-----DMQALKQSSTELLFGG 301
+ ++++ +I R E + D LQL+I+ + D++ + QS +F G
Sbjct: 249 LTKSVK-QIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSII-FIFAG 306
Query: 302 HETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVIK 361
+ETT+S + +I L +P V QKV++E+ + + + D + QL+Y+ V+
Sbjct: 307 YETTSSVLSFIIYELATHPDVQQKVQKEIDT---VLPNKAPPTYDTVL--QLEYLDMVVN 361
Query: 362 ETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFML 421
ETLRL P RV K E+NG IPKG V+ H + +T E+F P+RF
Sbjct: 362 ETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSK 421
Query: 422 PHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARH 462
+ ++ + + PFG G R+C+G FA + +K+ V + ++
Sbjct: 422 KNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQN 462
>gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide 2
[Homo sapiens]
Length = 520
Score = 97.4 bits (241), Expect = 3e-20
Identities = 85/359 (23%), Positives = 161/359 (44%), Gaps = 34/359 (9%)
Query: 120 LGSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEVGSSLEQWLSCGERG----- 174
LG G L + D + R+ ++ AF L+ Y+ + E V +W G
Sbjct: 132 LGDGLLLSAGDKWSRHRR-MLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLD 190
Query: 175 ------LLVYPEVKRLMFRIAMRILLGCEPQLAGDGDSEQQLVEAFEEMTRNLFSLPIDV 228
L+ +++ +F +A + + + E+ ++ L
Sbjct: 191 MFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLT 250
Query: 229 PFSGLYRGMKARNLIHARIEQNIRAKICGLRASEAGQGCKDALQ------------LLIE 276
P +R +A L+H + I+ + R + QG D LQ +L+
Sbjct: 251 PDGQRFR--RACRLVHDFTDAVIQER----RRTLPSQGVDDFLQAKAKSKTLDFIDVLLL 304
Query: 277 HSWERGERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLL 336
E G++L + ++ + +F GH+TTAS + ++ +L +P ++ R+E++ L
Sbjct: 305 SKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQE---L 361
Query: 337 CKSNQDNKLDMEILEQLKYIGCVIKETLRLNPPVPGGFRVALKTFEL-NGYQIPKGWNVI 395
K + +++ + L L ++ +KE+LRL+PPVP R + L +G IPKG +
Sbjct: 362 LKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICL 421
Query: 396 YSICDTHDVAEIFTNKEEFNPDRFMLPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKI 454
S+ TH ++ + E ++P RF + ++ S +FIPF G R+C+G+ FA +K+
Sbjct: 422 ISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKV 480
>gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide 12
[Homo sapiens]
Length = 524
Score = 97.1 bits (240), Expect = 3e-20
Identities = 56/195 (28%), Positives = 101/195 (51%), Gaps = 4/195 (2%)
Query: 269 DALQLLIEHSWERGERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVRE 328
D + +L+ E G+ L + ++ + +FGGH+TTAS + ++ L +P ++ R+
Sbjct: 297 DFIDVLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQ 356
Query: 329 ELKSKGLLCKSNQDNKLDMEILEQLKYIGCVIKETLRLNPPVPGGFRVALKTFEL-NGYQ 387
E++ L K +++ + L QL ++ +KE+LRL+PP P R + L +G
Sbjct: 357 EVQE---LLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRV 413
Query: 388 IPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPEDASRFSFIPFGGGLRSCVGKEF 447
IPKG + I H ++ + E ++P RF + + S +FIPF G R+C+G+ F
Sbjct: 414 IPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAF 473
Query: 448 AKILLKIFTVELARH 462
A +K+ + H
Sbjct: 474 AMAEMKVVLALMLLH 488
>gi|158138530 cytochrome P450, family 4, subfamily F, polypeptide 22
[Homo sapiens]
Length = 531
Score = 95.5 bits (236), Expect = 1e-19
Identities = 57/187 (30%), Positives = 100/187 (53%), Gaps = 4/187 (2%)
Query: 269 DALQLLIEHSWERGERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVRE 328
D + +L+ E G+ L + ++ + +F GH+TT+S + ++ L YP +K RE
Sbjct: 304 DFIDVLLLARDEDGKELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCRE 363
Query: 329 ELKSKGLLCKSNQDNKLDMEILEQLKYIGCVIKETLRLNPPVPGGFRVALKTFEL-NGYQ 387
E++ + K + +L+ + L QL + IKE+LR PPV R + +L +G
Sbjct: 364 EIQE---VMKGRELEELEWDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRI 420
Query: 388 IPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPEDASRFSFIPFGGGLRSCVGKEF 447
IPKG + SI TH ++ + + +NP RF +P+ S +++PF G R+C+G+ F
Sbjct: 421 IPKGIICLVSIYGTHHNPTVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQSF 480
Query: 448 AKILLKI 454
A L++
Sbjct: 481 AMAELRV 487
>gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide 4
[Homo sapiens]
Length = 503
Score = 95.1 bits (235), Expect = 1e-19
Identities = 104/434 (23%), Positives = 184/434 (42%), Gaps = 27/434 (6%)
Query: 46 PGTMGFPFFGETLQMVLQRRKFLQMKRRKYGFIYKTHLFGRPTVRVMGADNVRRILLGEH 105
PG PF G L F +KYG ++ + +P + + D ++ +L+ E
Sbjct: 39 PGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKEC 98
Query: 106 RLVSVHWPASVRTILGSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEVGSSLE 165
V + +S D K+ + ++ F+ L+ VP+I + +
Sbjct: 99 YSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVR 158
Query: 166 QWLSCGERGLLVYPEVKRLMFRIAMRILLGCEPQLAGDGDSEQQLVEAFEEMTRNL---- 221
E G V +K + +M ++ + D + Q + F E T+ L
Sbjct: 159 NLRREAETGKPV--TLKDVFGAYSMDVITSTSFGVNIDSLNNPQ--DPFVENTKKLLRFD 214
Query: 222 ----FSLPIDVPFSGLYRGMKARNL--IHARIEQNIRAKICGLRASEAGQGCK---DALQ 272
F L I V F L ++ N+ + +R + ++ S K D LQ
Sbjct: 215 FLDPFFLSITV-FPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQ 273
Query: 273 LLIEHS----WERGERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVRE 328
L+I+ E + L L S +F G+ETT+S + ++ L +P V QK++E
Sbjct: 274 LMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQE 333
Query: 329 ELKSKGLLCKSNQDNKLDMEILEQLKYIGCVIKETLRLNPPVPGGFRVALKTFELNGYQI 388
E+ + + + D + Q++Y+ V+ ETLRL P RV K E+NG I
Sbjct: 334 EIDA---VLPNKAPPTYDTVL--QMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFI 388
Query: 389 PKGWNVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPEDASRFSFIPFGGGLRSCVGKEFA 448
PKG V+ H + +T E+F P+RF + ++ + + PFG G R+C+G FA
Sbjct: 389 PKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFA 448
Query: 449 KILLKIFTVELARH 462
+ +K+ + + ++
Sbjct: 449 LMNMKLALIRVLQN 462
>gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide 43
isoform 1 [Homo sapiens]
Length = 504
Score = 95.1 bits (235), Expect = 1e-19
Identities = 111/463 (23%), Positives = 198/463 (42%), Gaps = 40/463 (8%)
Query: 46 PGTMGFPFFGETLQMVLQRRKFLQMKRRKYGFIYKTHLFGRPTVRVMGADNVRRILLGE- 104
PG PF G L + F + KYG ++ + +P + +M D ++ +L+ E
Sbjct: 39 PGPTPLPFLGTILFYLRGLWNFDRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKEC 98
Query: 105 HRLVSVHWPASVRTILGSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEVGSSL 164
+ + + P L S LS D K+ + ++ AF+ + VP+I++ +
Sbjct: 99 YSVFTNQMPLGPMGFLKSA-LSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLV 157
Query: 165 EQWLSCGERGLLVYPEVKRLMFRIAMRILLGC----------EPQLAGDGDSEQQLVEAF 214
E + +K M ++ G PQ + ++ L F
Sbjct: 158 RSLRQEAENSKSI--NLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDF 215
Query: 215 EEMTRNLFSL-PIDVP-FSGLYRGMKARNLIHARIEQNIRAKICGLRASEAGQGCKDALQ 272
+ L SL P P F L G+ +++ H R K L+ + + D Q
Sbjct: 216 LDPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLKNSIERMKESRLKDKQKHR--VDFFQ 273
Query: 273 LLIEHSWERGERL-----DMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVR 327
+I+ + + D++ + QS ++F ++TT++ ++ L +P V QK++
Sbjct: 274 QMIDSQNSKETKSHKALSDLELVAQSII-IIFAAYDTTSTTLPFIMYELATHPDVQQKLQ 332
Query: 328 EELKSKGLLCKSNQDNKLDM--EILEQLKYIGCVIKETLRLNPPVPGGFRVALKTFELNG 385
EE+ + NK + + L Q++Y+ V+ ETLRL P V RV K E+NG
Sbjct: 333 EEIDAV-------LPNKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEING 385
Query: 386 YQIPKGWNVIYSICDTHDVAEIFTNKEEFNPD-RFMLPHPEDASRFSFIPFGGGLRSCVG 444
IPKG V+ I H + +T E+F P+ RF + + + +IPFG G R+C+G
Sbjct: 386 VFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFSKKNKDSIDLYRYIPFGAGPRNCIG 445
Query: 445 KEFAKILLKIFTVELARHCDWQLLNGPPTMKTSPTVYPVDNLP 487
FA +K+ + ++ ++ K + +DNLP
Sbjct: 446 MRFALTNIKLAVIRALQNFSFK------PCKETQIPLKLDNLP 482
>gi|5729796 cytochrome P450, family 46 [Homo sapiens]
Length = 500
Score = 95.1 bits (235), Expect = 1e-19
Identities = 101/430 (23%), Positives = 195/430 (45%), Gaps = 36/430 (8%)
Query: 73 RKYGFIYKTHLFGRPTVRVMGADNVRRILLGEHRLVSVHWPASVRTILGS-----GCLSN 127
+KYG + + ++F + +V V ++V++ L+ +++T+ G G +S
Sbjct: 69 KKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSE 128
Query: 128 L-HDSSHKQRKKVIMRAFSREALECYVPVITEEVGSSLEQWLSCGE-------RGLLVYP 179
++ HKQR+ VI AFSR +L + E+ +E + + + +L Y
Sbjct: 129 CNYERWHKQRR-VIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYT 187
Query: 180 EVKRLM---FRIAMRILLGCEPQLAGDGDSEQQLVEAFEEMTRNLFSLPIDVPFSGLYRG 236
+ L F + +LLG + L+ Q + E +T + +L +P G +
Sbjct: 188 AMDILAKAAFGMETSMLLGAQKPLS------QAVKLMLEGITASRNTLAKFLP--GKRKQ 239
Query: 237 MK-ARNLIHARIEQNIRAKICGLRASEAGQGCKDALQLLIEHSWERGERLDMQALKQSST 295
++ R I R + + R +G + +L + D + L +
Sbjct: 240 LREVRESI--RFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFV 297
Query: 296 ELLFGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKY 355
GHET+A+ + L P ++ +++ E+ LD E L +L+Y
Sbjct: 298 TFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEV-----IGSKRYLDFEDLGRLQY 352
Query: 356 IGCVIKETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFN 415
+ V+KE+LRL PP G FR+ + ++G ++P +++S + F + FN
Sbjct: 353 LSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFN 412
Query: 416 PDRFMLPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLLNGPP-TM 474
PDRF P+ RF++ PF G RSC+G++FA++ +K+ +L + +++L+ G +
Sbjct: 413 PDRFGPGAPK--PRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGL 470
Query: 475 KTSPTVYPVD 484
+ T+ P+D
Sbjct: 471 QEQATLKPLD 480
>gi|29837648 cytochrome P450, family 4, subfamily X, polypeptide 1
[Homo sapiens]
Length = 509
Score = 95.1 bits (235), Expect = 1e-19
Identities = 87/361 (24%), Positives = 155/361 (42%), Gaps = 23/361 (6%)
Query: 119 ILGSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEVGSSLEQW---LSCGERGL 175
+LG G L+ L Q ++++ F L+ Y+ V+ V L++W S + +
Sbjct: 120 LLGKG-LAALDGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSV 178
Query: 176 LVYPEVKRLMFRIAMRILLGCEPQLAGDGDSEQQLVEAFEE---MTRNLFSLPI--DVPF 230
VY + + I M+ E + + FE + L+SL D+ F
Sbjct: 179 EVYEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIF 238
Query: 231 SGL---YRGMKARNLIHARIEQNIRAKICGLRASEAGQGC-----KDALQLLIEHSWERG 282
YR K +++ + I+ + L+A +D L +++ E G
Sbjct: 239 KLSPQGYRFQKLSRVLNQYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDESG 298
Query: 283 ERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQD 342
+ + L GH+T A++ + ++ L L P ++ REE++ G+L
Sbjct: 299 SSFSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVR--GIL---GDG 353
Query: 343 NKLDMEILEQLKYIGCVIKETLRLNPPVPGGFRVALKTFEL-NGYQIPKGWNVIYSICDT 401
+ + + L ++ Y IKET RL P VP R K +G +P G V+ SI
Sbjct: 354 SSITWDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGL 413
Query: 402 HDVAEIFTNKEEFNPDRFMLPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELAR 461
H ++ N + F+P RF + + ++++PF G R+C+G+EFA I LK+ +
Sbjct: 414 HHNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILL 473
Query: 462 H 462
H
Sbjct: 474 H 474
>gi|153218660 cytochrome P450, family 4, subfamily B, polypeptide 1
isoform b [Homo sapiens]
Length = 511
Score = 94.0 bits (232), Expect = 3e-19
Identities = 84/340 (24%), Positives = 148/340 (43%), Gaps = 26/340 (7%)
Query: 135 QRKKVIMRAFSREALECYVPVITEEVGSSLEQWLSCGERGLL--VYPEVKRLMFRIAMRI 192
Q +K++ F + L+ YV V TE L++W G ++ +V + M+
Sbjct: 136 QHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLMKC 195
Query: 193 LLGCEPQLAGDGDSEQQLVEAFEEMTRNLFSLPIDVPFSGLY---------RGMKARNLI 243
G G DS L A ++T + + + + R ++A +
Sbjct: 196 TFGRGDTGLGHRDSSYYL--AVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVA 253
Query: 244 HARIEQNIRAKICGLRASEAGQGCK-----DALQLLIEHSWERGERLDMQALKQSSTELL 298
H +Q IR + L+ + + + D L +L+ E +L L+ +
Sbjct: 254 HDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFM 313
Query: 299 FGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGC 358
F GH+TT S + + + LYP + REE++ +QD + L ++ Y+
Sbjct: 314 FEGHDTTTSGISWFLYCMALYPEHQHRCREEVRE----ILGDQDF-FQWDDLGKMTYLTM 368
Query: 359 VIKETLRLNPPVPGGFRVALK--TFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNP 416
IKE+ RL PPVP +R K TF ++G +P G + I H + ++ + E F+
Sbjct: 369 CIKESFRLYPPVPQVYRQLSKPVTF-VDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDS 427
Query: 417 DRFMLPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFT 456
RF + F+F+PF G R+C+G++FA +K+ T
Sbjct: 428 LRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVT 467
>gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5
[Homo sapiens]
Length = 502
Score = 92.4 bits (228), Expect = 8e-19
Identities = 109/460 (23%), Positives = 188/460 (40%), Gaps = 31/460 (6%)
Query: 22 LAAIKLWDLYCVSGRDRSCALPLP-PGTMGFPFFGETLQMVLQRRKFLQMKRRKYGFIYK 80
L A+ L LY R L PG P G L KF +KYG ++
Sbjct: 14 LLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKMWG 73
Query: 81 THLFGRPTVRVMGADNVRRILLGEHRLVSVHWPASVRTILGSGCLSNLHDSSHKQRKKVI 140
T+ P + + D +R +L+ E V + + +S D K+ + ++
Sbjct: 74 TYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLL 133
Query: 141 MRAFSREALECYVPVITEEVGSSLEQWLSCGERGLLVYPEVKRLMFRIAMRILLGCEPQL 200
F+ L+ P+I + + E+G V +K + +M ++ G +
Sbjct: 134 SPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPV--TLKDIFGAYSMDVITGTSFGV 191
Query: 201 AGDGDSEQQLVEAFEEMTR-------------NLFSLPIDVP-FSGLYRGMKARNLIHAR 246
D + Q + F E T+ ++ P P F L + ++ I+
Sbjct: 192 NIDSLNNPQ--DPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFL 249
Query: 247 IEQNIRAKICGLRASEAGQGCKDALQLLIEHS----WERGERLDMQALKQSSTELLFGGH 302
+ R K L + + D LQL+I+ E + L L S +F G+
Sbjct: 250 SKSVNRMKKSRLNDKQKHR--LDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGY 307
Query: 303 ETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVIKE 362
ETT+S + + L +P V QK+++E+ + + + D + Q++Y+ V+ E
Sbjct: 308 ETTSSVLSFTLYELATHPDVQQKLQKEIDA---VLPNKAPPTYDAVV--QMEYLDMVVNE 362
Query: 363 TLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFMLP 422
TLRL P R K E+NG IPKG V+ H + +T EEF P+RF
Sbjct: 363 TLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS-K 421
Query: 423 HPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARH 462
+ + + PFG G R+C+G FA + +K+ + + ++
Sbjct: 422 KKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQN 461
>gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8
[Homo sapiens]
Length = 520
Score = 92.0 bits (227), Expect = 1e-18
Identities = 53/187 (28%), Positives = 101/187 (54%), Gaps = 4/187 (2%)
Query: 269 DALQLLIEHSWERGERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVRE 328
D + +L+ + G+ L + ++ + +FGGH+TTAS + ++ L +P ++ R+
Sbjct: 297 DFIDVLLLSEDKNGKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQ 356
Query: 329 ELKSKGLLCKSNQDNKLDMEILEQLKYIGCVIKETLRLNPPVPGGFRVALKTFEL-NGYQ 387
E++ L K + +++ + L QL ++ +KE+LRL+PP+P R + L +
Sbjct: 357 EVQE---LLKDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSRV 413
Query: 388 IPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPEDASRFSFIPFGGGLRSCVGKEF 447
IPKG +I H ++ + E ++P RF + + S +FIPF G R+C+G++F
Sbjct: 414 IPKGNVCNINIFAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQKF 473
Query: 448 AKILLKI 454
A +K+
Sbjct: 474 AMAEMKV 480
>gi|153218662 cytochrome P450, family 4, subfamily B, polypeptide 1
isoform a [Homo sapiens]
Length = 512
Score = 91.3 bits (225), Expect = 2e-18
Identities = 84/341 (24%), Positives = 149/341 (43%), Gaps = 27/341 (7%)
Query: 135 QRKKVIMRAFSREALECYVPVITEEVGSSLEQWLSCGERGLL--VYPEVKRLMFRIAMRI 192
Q +K++ F + L+ YV V TE L++W G ++ +V + M+
Sbjct: 136 QHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLMKC 195
Query: 193 LLGC-EPQLAGDGDSEQQLVEAFEEMTRNLFSLPIDVPFSGLY---------RGMKARNL 242
G + L DS L A ++T + + + + R ++A +
Sbjct: 196 TFGRGDTGLGHSRDSSYYL--AVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQV 253
Query: 243 IHARIEQNIRAKICGLRASEAGQGCK-----DALQLLIEHSWERGERLDMQALKQSSTEL 297
H +Q IR + L+ + + + D L +L+ E +L L+
Sbjct: 254 AHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTF 313
Query: 298 LFGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIG 357
+F GH+TT S + + + LYP + REE++ +QD + L ++ Y+
Sbjct: 314 MFEGHDTTTSGISWFLYCMALYPEHQHRCREEVRE----ILGDQDF-FQWDDLGKMTYLT 368
Query: 358 CVIKETLRLNPPVPGGFRVALK--TFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFN 415
IKE+ RL PPVP +R K TF ++G +P G + I H + ++ + E F+
Sbjct: 369 MCIKESFRLYPPVPQVYRQLSKPVTF-VDGRSLPAGSLISMHIYALHRNSAVWPDPEVFD 427
Query: 416 PDRFMLPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFT 456
RF + F+F+PF G R+C+G++FA +K+ T
Sbjct: 428 SLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVT 468
>gi|30023836 cytochrome P450 4Z1 [Homo sapiens]
Length = 505
Score = 90.5 bits (223), Expect = 3e-18
Identities = 85/345 (24%), Positives = 144/345 (41%), Gaps = 20/345 (5%)
Query: 125 LSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEVGSSLEQWLS--CGERGLLVYPEVK 182
L L S K+ ++++ F+ L+ ++ +++E V L +W L ++ V
Sbjct: 125 LVTLDGSKWKKHRQIVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNSRLELFQHVS 184
Query: 183 RLMFRIAMRILLGCEPQLAGDGDSEQQLVEAFE-----EMTRNLFSLPIDVPFSGLYRGM 237
+ M+ + + D + L F N F D+ F +G
Sbjct: 185 LMTLDSIMKCAFSHQGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHNDLVFKFSSQGQ 244
Query: 238 ---KARNLIHARIEQNIRAKICGLRASEAGQGCK----DALQLLIEHSWERGERLDMQAL 290
K +H E+ I+ + L+ + D L +L+ E + L
Sbjct: 245 IFSKFNQELHQFTEKVIQDRKESLKDKLKQDTTQKRRWDFLDILLSAKSENTKDFSEADL 304
Query: 291 KQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEIL 350
+ +F GH+TT+SA + ++ L YP Q+ R+E++ LL + + E L
Sbjct: 305 QAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRE--LL---GDGSSITWEHL 359
Query: 351 EQLKYIGCVIKETLRLNPPVPGGFRVALKTFEL-NGYQIPKGWNVIYSICDTHDVAEIFT 409
Q+ Y IKE LRL PV R+ K +G +P G V +I H +
Sbjct: 360 SQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINIWALHHNPYFWE 419
Query: 410 NKEEFNPDRFMLPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKI 454
+ + FNP RF + E ++FIPF GLR+C+G+ FA I K+
Sbjct: 420 DPQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKV 464
>gi|13449277 cytochrome P450, family 2, subfamily S, polypeptide 1
[Homo sapiens]
Length = 504
Score = 86.7 bits (213), Expect = 5e-17
Identities = 132/502 (26%), Positives = 187/502 (37%), Gaps = 51/502 (10%)
Query: 18 LLLFLAAIKLWDLYCVSGRDRSCALPLPPGTMGFPFFGETLQMVLQRR-KFLQMKRRKYG 76
LLL LA + L L R R LPPG P G LQ+ L +KYG
Sbjct: 9 LLLALALLLLLTLALSGTRARG---HLPPGPTPLPLLGNLLQLRPGALYSGLMRLSKKYG 65
Query: 77 FIYKTHLFG-RPTVRVMGADNVRRILLGEHRLVSVHWPASVR--TILGSGCLSNLHDSSH 133
++ +L RP V ++G + VR L G+ S ++ T G G + +
Sbjct: 66 PVFTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGHGVFFS-NGERW 124
Query: 134 KQRKKVIMRAF------SREALE-------CYVPVITEEVGSSLEQWLSCGER------- 173
+Q +K M A RE E C V G + L +
Sbjct: 125 RQLRKFTMLALRDLGMGKREGEELIQAEARCLVETFQGTEGRPFDPSLLLAQATSNVVCS 184
Query: 174 ---GLLVYPEVKRLMFRIAMRILLGCEPQLAGDGDSEQQLVEAFEEMTRNLFSLPIDVPF 230
GL E K F+ +R G L G Q E F R P+ P
Sbjct: 185 LLFGLRFSYEDKE--FQAVVRAAGGT---LLGVSSQGGQTYEMFSWFLR-----PLPGPH 234
Query: 231 SGLYRGMKARNLIHARIEQNIRAKICGLRASEAGQGCKDALQL-LIEHSWERGERLDMQA 289
L + R Q + L AS + DA L + + G +
Sbjct: 235 KQLLHHVSTLAAFTVRQVQQHQGN---LDASGPARDLVDAFLLKMAQEEQNPGTEFTNKN 291
Query: 290 LKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEI 349
+ + LLF G T ++ + L YPHV + VREEL + + Q L
Sbjct: 292 MLMTVIYLLFAGTMTVSTTVGYTLLLLMKYPHVQKWVREELNRE---LGAGQAPSLGDR- 347
Query: 350 LEQLKYIGCVIKETLRLNPPVPGGF-RVALKTFELNGYQIPKGWNVIYSICDTHDVAEIF 408
+L Y V+ E RL VP G R ++T GY +P+G V + IF
Sbjct: 348 -TRLPYTDAVLHEAQRLLALVPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIF 406
Query: 409 TNKEEFNPDRFMLPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLL 468
+ EEFNPDRF+ +F+PF G R C+G+ AK L +F + + +
Sbjct: 407 KHPEEFNPDRFLDADGRFRKHEAFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSLESP 466
Query: 469 NGPPTMKTSPTVYPVDNLPARF 490
P T+ PTV + N+P F
Sbjct: 467 CPPDTLSLKPTVSGLFNIPPAF 488
>gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1
isoform 1 precursor [Homo sapiens]
Length = 514
Score = 85.5 bits (210), Expect = 1e-16
Identities = 64/208 (30%), Positives = 100/208 (48%), Gaps = 7/208 (3%)
Query: 284 RLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDN 343
RL + L + TEL ETTA++ ++ L P V QK+ +E++S + NQ
Sbjct: 310 RLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQS---VLPENQVP 366
Query: 344 KLDMEILEQLKYIGCVIKETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHD 403
+ E L + Y+ +KE++RL P VP R K L Y +PKG ++ +
Sbjct: 367 RA--EDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQVLGS 424
Query: 404 VAEIFTNKEEFNPDRFMLPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHC 463
+ F + +F P+R+ L E + F+ +PFG G R C+G+ A++ L + + R
Sbjct: 425 SEDNFEDSSQFRPERW-LQEKEKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKY 483
Query: 464 DWQLL-NGPPTMKTSPTVYPVDNLPARF 490
D Q N P M S T+ P LP F
Sbjct: 484 DIQATDNEPVEMLHSGTLVPSRELPIAF 511
>gi|167466231 cytochrome P450, family 27, subfamily C, polypeptide 1
[Homo sapiens]
Length = 372
Score = 85.5 bits (210), Expect = 1e-16
Identities = 56/182 (30%), Positives = 94/182 (51%), Gaps = 8/182 (4%)
Query: 283 ERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKV-REELKSKGLLCKSNQ 341
+ L +Q + + TE+L G +TT+ + + L +P V Q V RE +K+ G + +
Sbjct: 163 QALTLQEIYANVTEMLLAGVDTTSFTLSWTVYLLARHPEVQQTVYREIVKNLG---ERHV 219
Query: 342 DNKLDMEILEQLKYIGCVIKETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDT 401
D+ ++ + ++KETLRL P +PG RV + + GY IPKG + T
Sbjct: 220 PTAADVP---KVPLVRALLKETLRLFPVLPGNGRVTQEDLVIGGYLIPKGTQLALCHYAT 276
Query: 402 HDVAEIFTNKEEFNPDRFMLPHPED-ASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELA 460
E F +EF P+R++ D F IPFG G+RSC+G+ A++ + + ++L
Sbjct: 277 SYQDENFPRAKEFRPERWLRKGDLDRVDNFGSIPFGHGVRSCIGRRIAELEIHLVVIQLL 336
Query: 461 RH 462
+H
Sbjct: 337 QH 338
>gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide 1
[Homo sapiens]
Length = 508
Score = 80.9 bits (198), Expect = 3e-15
Identities = 63/217 (29%), Positives = 101/217 (46%), Gaps = 20/217 (9%)
Query: 283 ERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQD 342
E L Q++ + TELL G +T ++ + + L +P V + E+ +
Sbjct: 300 EELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAA---LSPGSS 356
Query: 343 NKLDMEILEQLKYIGCVIKETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSIC--- 399
+L QL + V+KE LRL P VPG RV K + Y IPK N + ++C
Sbjct: 357 AYPSATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPK--NTLVTLCHYA 414
Query: 400 DTHDVAEIFTNKEEFNPDRFM----LPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIF 455
+ D A+ F F P R++ PHP F+ +PFG G RSC+G+ A++ L++
Sbjct: 415 TSRDPAQ-FPEPNSFRPARWLGEGPTPHP-----FASLPFGFGKRSCMGRRLAELELQMA 468
Query: 456 TVELARHCDWQLLNG--PPTMKTSPTVYPVDNLPARF 490
++ H + Q G P KT + P ++ +F
Sbjct: 469 LAQILTHFEVQPEPGAAPVRPKTRTVLVPERSINLQF 505
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.140 0.432
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,561,283
Number of Sequences: 37866
Number of extensions: 873633
Number of successful extensions: 2635
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 59
Number of HSP's successfully gapped in prelim test: 16
Number of HSP's that attempted gapping in prelim test: 2431
Number of HSP's gapped (non-prelim): 103
length of query: 497
length of database: 18,247,518
effective HSP length: 106
effective length of query: 391
effective length of database: 14,233,722
effective search space: 5565385302
effective search space used: 5565385302
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.5 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.