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Search of human proteins with 11141889
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|11141889 WW45 protein [Homo sapiens]
(383 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|11141889 WW45 protein [Homo sapiens] 803 0.0
gi|66346708 membrane associated guanylate kinase, WW and PDZ dom... 75 8e-14
gi|74272284 membrane associated guanylate kinase, WW and PDZ dom... 75 8e-14
gi|74272282 membrane associated guanylate kinase, WW and PDZ dom... 75 8e-14
gi|218505835 membrane-associated guanylate kinase-related 3 iso... 75 8e-14
gi|155969695 membrane-associated guanylate kinase-related 3 iso... 75 8e-14
gi|27436957 membrane associated guanylate kinase, WW and PDZ dom... 75 1e-13
gi|13654239 WW domain containing E3 ubiquitin protein ligase 1 [... 72 1e-12
gi|40806207 WW domain containing E3 ubiquitin protein ligase 2 i... 70 3e-12
gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapi... 70 4e-12
gi|156546890 WW and C2 domain containing 2 [Homo sapiens] 65 8e-11
gi|29789058 WW and C2 domain containing 1 isoform 3 [Homo sapiens] 62 1e-09
gi|242247257 WW and C2 domain containing 1 isoform 2 [Homo sapiens] 62 1e-09
gi|242247251 WW and C2 domain containing 1 isoform 1 [Homo sapiens] 62 1e-09
gi|222352183 neural precursor cell expressed, developmentally do... 60 4e-09
gi|21361472 neural precursor cell expressed, developmentally dow... 60 4e-09
gi|222352094 neural precursor cell expressed, developmentally do... 60 4e-09
gi|222352092 neural precursor cell expressed, developmentally do... 60 4e-09
gi|222352090 neural precursor cell expressed, developmentally do... 60 4e-09
gi|222352088 neural precursor cell expressed, developmentally do... 60 4e-09
gi|222352086 neural precursor cell expressed, developmentally do... 60 4e-09
gi|222352084 neural precursor cell expressed, developmentally do... 60 4e-09
gi|222352082 neural precursor cell expressed, developmentally do... 60 4e-09
gi|7706523 WW domain-containing oxidoreductase isoform 1 [Homo s... 58 1e-08
gi|18860884 WW domain-containing oxidoreductase isoform 2 [Homo ... 58 1e-08
gi|114520609 neural precursor cell expressed, developmentally do... 55 8e-08
gi|114520607 neural precursor cell expressed, developmentally do... 55 8e-08
gi|194306653 Yes-associated protein 1, 65kDa isoform 1 [Homo sap... 54 3e-07
gi|19923493 pleckstrin homology domain containing, family A memb... 53 4e-07
gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [H... 52 1e-06
>gi|11141889 WW45 protein [Homo sapiens]
Length = 383
Score = 803 bits (2074), Expect = 0.0
Identities = 383/383 (100%), Positives = 383/383 (100%)
Query: 1 MLSRKKTKNEVSKPAEVQGKYVKKETSPLLRNLMPSFIRHGPTIPRRTDICLPDSSPNAF 60
MLSRKKTKNEVSKPAEVQGKYVKKETSPLLRNLMPSFIRHGPTIPRRTDICLPDSSPNAF
Sbjct: 1 MLSRKKTKNEVSKPAEVQGKYVKKETSPLLRNLMPSFIRHGPTIPRRTDICLPDSSPNAF 60
Query: 61 STSGDVVSRNQSFLRTPIQRTPHEIMRRESNRLSAPSYLARSLADVPREYGSSQSFVTEV 120
STSGDVVSRNQSFLRTPIQRTPHEIMRRESNRLSAPSYLARSLADVPREYGSSQSFVTEV
Sbjct: 61 STSGDVVSRNQSFLRTPIQRTPHEIMRRESNRLSAPSYLARSLADVPREYGSSQSFVTEV 120
Query: 121 SFAVENGDSGSRYYYSDNFFDGQRKRPLGDRAHEDYRYYEYNHDLFQRMPQNQGRHASGI 180
SFAVENGDSGSRYYYSDNFFDGQRKRPLGDRAHEDYRYYEYNHDLFQRMPQNQGRHASGI
Sbjct: 121 SFAVENGDSGSRYYYSDNFFDGQRKRPLGDRAHEDYRYYEYNHDLFQRMPQNQGRHASGI 180
Query: 181 GRVAATSLGNLTNHGSEDLPLPPGWSVDWTMRGRKYYIDHNTNTTHWSHPLEREGLPPGW 240
GRVAATSLGNLTNHGSEDLPLPPGWSVDWTMRGRKYYIDHNTNTTHWSHPLEREGLPPGW
Sbjct: 181 GRVAATSLGNLTNHGSEDLPLPPGWSVDWTMRGRKYYIDHNTNTTHWSHPLEREGLPPGW 240
Query: 241 ERVESSEFGTYYVDHTNKKAQYRHPCAPSVPRYDQPPPVTYQPQQTERNQSLLVPANPYH 300
ERVESSEFGTYYVDHTNKKAQYRHPCAPSVPRYDQPPPVTYQPQQTERNQSLLVPANPYH
Sbjct: 241 ERVESSEFGTYYVDHTNKKAQYRHPCAPSVPRYDQPPPVTYQPQQTERNQSLLVPANPYH 300
Query: 301 TAEIPDWLQVYARAPVKYDHILKWELFQLADLDTYQGMLKLLFMKELEQIVKMYEAYRQA 360
TAEIPDWLQVYARAPVKYDHILKWELFQLADLDTYQGMLKLLFMKELEQIVKMYEAYRQA
Sbjct: 301 TAEIPDWLQVYARAPVKYDHILKWELFQLADLDTYQGMLKLLFMKELEQIVKMYEAYRQA 360
Query: 361 LLTELENRKQRQQWYAQQHGKNF 383
LLTELENRKQRQQWYAQQHGKNF
Sbjct: 361 LLTELENRKQRQQWYAQQHGKNF 383
>gi|66346708 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform b [Homo sapiens]
Length = 1256
Score = 75.5 bits (184), Expect = 8e-14
Identities = 49/146 (33%), Positives = 63/146 (43%), Gaps = 39/146 (26%)
Query: 200 PLPPGWSVDWTMRGRKYYIDHNTNTTHW---------SHPLER----EG----------- 235
PLP W + +T G Y+IDHNT TT W PLE EG
Sbjct: 301 PLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPLEECEDDEGVHTEELDSELE 360
Query: 236 LPPGWERVESSEFGTYYVDHTNKKAQYRHPC--APSVPRYDQPPPVTYQPQQ-------- 285
LP GWE++E +G YYVDH N+K QY +P A + +Q Q QQ
Sbjct: 361 LPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQQQQQQQQ 420
Query: 286 -----TERNQSLLVPANPYHTAEIPD 306
TE + +L+ P P H P+
Sbjct: 421 QTEEWTEDHSALVPPVIPNHPPSNPE 446
>gi|74272284 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform c [Homo sapiens]
Length = 1462
Score = 75.5 bits (184), Expect = 8e-14
Identities = 49/146 (33%), Positives = 63/146 (43%), Gaps = 39/146 (26%)
Query: 200 PLPPGWSVDWTMRGRKYYIDHNTNTTHW---------SHPLER----EG----------- 235
PLP W + +T G Y+IDHNT TT W PLE EG
Sbjct: 301 PLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPLEECEDDEGVHTEELDSELE 360
Query: 236 LPPGWERVESSEFGTYYVDHTNKKAQYRHPC--APSVPRYDQPPPVTYQPQQ-------- 285
LP GWE++E +G YYVDH N+K QY +P A + +Q Q QQ
Sbjct: 361 LPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQQQQQQQQ 420
Query: 286 -----TERNQSLLVPANPYHTAEIPD 306
TE + +L+ P P H P+
Sbjct: 421 QTEEWTEDHSALVPPVIPNHPPSNPE 446
>gi|74272282 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform a [Homo sapiens]
Length = 1287
Score = 75.5 bits (184), Expect = 8e-14
Identities = 49/146 (33%), Positives = 63/146 (43%), Gaps = 39/146 (26%)
Query: 200 PLPPGWSVDWTMRGRKYYIDHNTNTTHW---------SHPLER----EG----------- 235
PLP W + +T G Y+IDHNT TT W PLE EG
Sbjct: 301 PLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPLEECEDDEGVHTEELDSELE 360
Query: 236 LPPGWERVESSEFGTYYVDHTNKKAQYRHPC--APSVPRYDQPPPVTYQPQQ-------- 285
LP GWE++E +G YYVDH N+K QY +P A + +Q Q QQ
Sbjct: 361 LPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQQQQQQQQ 420
Query: 286 -----TERNQSLLVPANPYHTAEIPD 306
TE + +L+ P P H P+
Sbjct: 421 QTEEWTEDHSALVPPVIPNHPPSNPE 446
>gi|218505835 membrane-associated guanylate kinase-related 3
isoform 1 [Homo sapiens]
Length = 1481
Score = 75.5 bits (184), Expect = 8e-14
Identities = 34/77 (44%), Positives = 44/77 (57%), Gaps = 11/77 (14%)
Query: 200 PLPPGWSVDWTMRGRKYYIDHNTNTTHWSHP-----------LEREGLPPGWERVESSEF 248
PLP W + +T G Y+IDHNT TT W P E LP GWE++E ++
Sbjct: 294 PLPKNWEMAYTDTGMIYFIDHNTKTTTWLDPRLCKKAKAPEDCEDGELPYGWEKIEDPQY 353
Query: 249 GTYYVDHTNKKAQYRHP 265
GTYYVDH N+K Q+ +P
Sbjct: 354 GTYYVDHLNQKTQFENP 370
>gi|155969695 membrane-associated guanylate kinase-related 3
isoform 2 [Homo sapiens]
Length = 1125
Score = 75.5 bits (184), Expect = 8e-14
Identities = 34/77 (44%), Positives = 44/77 (57%), Gaps = 11/77 (14%)
Query: 200 PLPPGWSVDWTMRGRKYYIDHNTNTTHWSHP-----------LEREGLPPGWERVESSEF 248
PLP W + +T G Y+IDHNT TT W P E LP GWE++E ++
Sbjct: 294 PLPKNWEMAYTDTGMIYFIDHNTKTTTWLDPRLCKKAKAPEDCEDGELPYGWEKIEDPQY 353
Query: 249 GTYYVDHTNKKAQYRHP 265
GTYYVDH N+K Q+ +P
Sbjct: 354 GTYYVDHLNQKTQFENP 370
>gi|27436957 membrane associated guanylate kinase, WW and PDZ domain
containing 2 [Homo sapiens]
Length = 1455
Score = 74.7 bits (182), Expect = 1e-13
Identities = 32/77 (41%), Positives = 46/77 (59%), Gaps = 11/77 (14%)
Query: 200 PLPPGWSVDWTMRGRKYYIDHNTNTTHWSHP-LEREGLPP----------GWERVESSEF 248
PLP W + +T +G Y+IDHNT TT W P L ++ PP GWE+++ +
Sbjct: 303 PLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGWEKIDDPIY 362
Query: 249 GTYYVDHTNKKAQYRHP 265
GTYYVDH N++ Q+ +P
Sbjct: 363 GTYYVDHINRRTQFENP 379
>gi|13654239 WW domain containing E3 ubiquitin protein ligase 1
[Homo sapiens]
Length = 922
Score = 71.6 bits (174), Expect = 1e-12
Identities = 36/90 (40%), Positives = 45/90 (50%), Gaps = 11/90 (12%)
Query: 201 LPPGWSVDWTMRGRKYYIDHNTNTTHWSHPLEREGLPPGWERVESSEFGTYYVDHTNKKA 260
LP GW GR YY+DHNT TT W P + LPPGWER YYVDH +
Sbjct: 351 LPSGWEQRKDPHGRTYYVDHNTRTTTWERP---QPLPPGWERRVDDRRRVYYVDHNTRTT 407
Query: 261 QYRHPCAPSVPRYDQPPPVTYQPQQTERNQ 290
++ P SV ++Q Q++RNQ
Sbjct: 408 TWQRPTMESVRNFEQ--------WQSQRNQ 429
Score = 59.3 bits (142), Expect = 6e-09
Identities = 42/144 (29%), Positives = 59/144 (40%), Gaps = 14/144 (9%)
Query: 128 DSGSRYYYSD-NFFDGQRKRPLGDRAHEDYRYYEYNHDLFQRMPQNQGRHASGIGRVAAT 186
D R YY D N +RP + ++ + L M Q R+ +AA
Sbjct: 392 DDRRRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQLQGAMQQFNQRYLYSASMLAAE 451
Query: 187 SLGNLTNHGSEDLPLPPGWSVDWTMRGRKYYIDHNTNTTHWSHP-----LEREGLPPGWE 241
+ +G PLPPGW R Y+++HNT TT W P E LP GWE
Sbjct: 452 N----DPYG----PLPPGWEKRVDSTDRVYFVNHNTKTTQWEDPRTQGLQNEEPLPEGWE 503
Query: 242 RVESSEFGTYYVDHTNKKAQYRHP 265
+ E Y+VDH + ++ P
Sbjct: 504 IRYTREGVRYFVDHNTRTTTFKDP 527
Score = 58.5 bits (140), Expect = 1e-08
Identities = 75/331 (22%), Positives = 114/331 (34%), Gaps = 66/331 (19%)
Query: 26 TSPLLRNLMPSFIRHGPTIPRRTDICL------PDSSPNAFSTSGDVVS-RNQSFLRTPI 78
TS L++N S++ +G P P P A + D V+ + SF T
Sbjct: 195 TSTLVQNSCCSYVVNGDNTPSSPSQVAARPKNTPAPKPLASEPADDTVNGESSSFAPTDN 254
Query: 79 QRTPHEIMRRESNRLSAPSYLARSLADVPREY------------GSSQSFVTEVSFAVEN 126
+ E N LS P+ + ++ D P + +S +E +E
Sbjct: 255 ASVTGTPVVSEENALS-PNCTSTTVEDPPVQEILTSSENNECIPSTSAELESEARSILEP 313
Query: 127 GDSGSRYYYSDNFFDGQRKRPLGDRAHEDYRYYEYNHDLFQRMPQNQGRHASGIGRVAAT 186
S SR S + F+ + R D + R N + + +P + GR
Sbjct: 314 DTSNSR---SSSAFEAAKSRQ-PDGCMDPVRQQSGNANT-ETLPSGWEQRKDPHGRTYYV 368
Query: 187 SLGNLTNHGSEDLPLPPGWSVDWTMRGRKYYIDHNTNTTHWSHPL--------------- 231
T PLPPGW R R YY+DHNT TT W P
Sbjct: 369 DHNTRTTTWERPQPLPPGWERRVDDRRRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRN 428
Query: 232 EREG-------------------------LPPGWERVESSEFGTYYVDHTNKKAQYRHPC 266
+ +G LPPGWE+ S Y+V+H K Q+ P
Sbjct: 429 QLQGAMQQFNQRYLYSASMLAAENDPYGPLPPGWEKRVDSTDRVYFVNHNTKTTQWEDPR 488
Query: 267 APSVPRYDQPPPVTYQPQQTERNQSLLVPAN 297
+ + ++P P ++ + T V N
Sbjct: 489 TQGL-QNEEPLPEGWEIRYTREGVRYFVDHN 518
>gi|40806207 WW domain containing E3 ubiquitin protein ligase 2
isoform 1 [Homo sapiens]
Length = 870
Score = 70.1 bits (170), Expect = 3e-12
Identities = 39/104 (37%), Positives = 49/104 (47%), Gaps = 21/104 (20%)
Query: 195 GSEDLP--------LPPGWSVDWTMRGRKYYIDHNTNTTHWSHPLEREGLPPGWERVESS 246
G++ LP LP GW GR YY+DHNT TT W P LPPGWE+
Sbjct: 288 GTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERP-----LPPGWEKRTDP 342
Query: 247 EFGTYYVDHTNKKAQYRHPCAPSVPRYDQPPPVTYQPQQTERNQ 290
YYVDH + ++ P A V Y+Q Q++RNQ
Sbjct: 343 RGRFYYVDHNTRTTTWQRPTAEYVRNYEQ--------WQSQRNQ 378
Score = 53.9 bits (128), Expect = 2e-07
Identities = 34/119 (28%), Positives = 45/119 (37%), Gaps = 41/119 (34%)
Query: 200 PLPPGWSVDWTMRGRKYYIDHNTNTTHWSHPL---------------EREG--------- 235
PLPPGW RGR YY+DHNT TT W P + +G
Sbjct: 331 PLPPGWEKRTDPRGRFYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRF 390
Query: 236 ----------------LPPGWERVESSEFGTYYVDHTNKKAQYRHPCAPSVPRYDQPPP 278
LPPGWE+ + + YYV+H + Q+ P + + PP
Sbjct: 391 LYQSSSASTDHDPLGPLPPGWEKRQDNG-RVYYVNHNTRTTQWEDPRTQGMIQEPALPP 448
Score = 45.8 bits (107), Expect = 6e-05
Identities = 44/169 (26%), Positives = 66/169 (39%), Gaps = 25/169 (14%)
Query: 101 RSLADVPREYGSSQSFVTEVSFAVENGDSGSRYYYSDNFFDGQRKRPLG---DRAHEDYR 157
R A+ R Y QS ++ A+++ Y S D PL ++ ++ R
Sbjct: 360 RPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHDPLGPLPPGWEKRQDNGR 419
Query: 158 YYEYNHDLFQRMPQNQGRHASGIGRVAATSLGNLTNHGSEDLPLPPGWSVDWTMRGRKYY 217
Y NH+ R Q + G+ + A LPPGW + +T G +Y+
Sbjct: 420 VYYVNHNT--RTTQWEDPRTQGMIQEPA---------------LPPGWEMKYTSEGVRYF 462
Query: 218 IDHNTNTTHWSHPLEREGLPPGWERVESSEFGTYYVDHTNKKAQYRHPC 266
+DHNT TT + P R G G + G Y K Q+R C
Sbjct: 463 VDHNTRTTTFKDP--RPGFESG---TKQGSPGAYDRSFRWKYHQFRFLC 506
Score = 36.6 bits (83), Expect = 0.039
Identities = 19/66 (28%), Positives = 24/66 (36%)
Query: 234 EGLPPGWERVESSEFGTYYVDHTNKKAQYRHPCAPSVPRYDQPPPVTYQPQQTERNQSLL 293
+ LP GWE+ E YYVDH K + P P + P Y R +
Sbjct: 300 DALPAGWEQRELPNGRVYYVDHNTKTTTWERPLPPGWEKRTDPRGRFYYVDHNTRTTTWQ 359
Query: 294 VPANPY 299
P Y
Sbjct: 360 RPTAEY 365
>gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo
sapiens]
Length = 862
Score = 69.7 bits (169), Expect = 4e-12
Identities = 33/76 (43%), Positives = 39/76 (51%), Gaps = 3/76 (3%)
Query: 200 PLPPGWSVDWTMRGRKYYIDHNTNTTHWSHPLEREGLPPGWERVESSEFGTYYVDHTNKK 259
PLPPGW GR YY+DH T W P E LPPGWER + YYVDH +
Sbjct: 286 PLPPGWEQRVDQHGRVYYVDHVEKRTTWDRP---EPLPPGWERRVDNMGRIYYVDHFTRT 342
Query: 260 AQYRHPCAPSVPRYDQ 275
++ P SV Y+Q
Sbjct: 343 TTWQRPTLESVRNYEQ 358
Score = 59.7 bits (143), Expect = 4e-09
Identities = 46/160 (28%), Positives = 63/160 (39%), Gaps = 10/160 (6%)
Query: 128 DSGSRYYYSDNFFDGQR-KRPLGDRAHEDYRYYEYNHDLFQRMPQNQGRHASGIGRVAAT 186
D+ R YY D+F +RP + ++ L M Q R G + AT
Sbjct: 328 DNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIYGNQDLFAT 387
Query: 187 SLGNLTNHGSEDLPLPPGWSVDWTMRGRKYYIDHNTNTTHWSHP-----LEREGLPPGWE 241
S + PLPPGW GR Y+++HNT T W P L + LP GWE
Sbjct: 388 SQSKEFDPLG---PLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNEKPLPEGWE 444
Query: 242 RVESSEFGTYYVDHTNKKAQYRHPCAPSVPRYDQPPPVTY 281
+ + Y+VDH + Y P D P + Y
Sbjct: 445 MRFTVDGIPYFVDHNRRTTTYIDP-RTGKSALDNGPQIAY 483
Score = 36.2 bits (82), Expect = 0.051
Identities = 14/37 (37%), Positives = 20/37 (54%)
Query: 229 HPLEREGLPPGWERVESSEFGTYYVDHTNKKAQYRHP 265
+P+ + LPPGWE+ YYVDH K+ + P
Sbjct: 280 NPVTQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRP 316
>gi|156546890 WW and C2 domain containing 2 [Homo sapiens]
Length = 1192
Score = 65.5 bits (158), Expect = 8e-11
Identities = 33/83 (39%), Positives = 39/83 (46%), Gaps = 12/83 (14%)
Query: 195 GSEDLPLPPGWSVDWTMRGRKYYIDHNTNTTHWSHPLER------------EGLPPGWER 242
GS LPLP GW G+ +YIDHNT T W P +R + LP GWE
Sbjct: 6 GSGQLPLPRGWEEARDYDGKVFYIDHNTRRTSWIDPRDRLTKPLSFADCVGDELPWGWEA 65
Query: 243 VESSEFGTYYVDHTNKKAQYRHP 265
+ G YY+DH NK Q P
Sbjct: 66 GFDPQIGVYYIDHINKTTQIEDP 88
>gi|29789058 WW and C2 domain containing 1 isoform 3 [Homo sapiens]
Length = 1113
Score = 61.6 bits (148), Expect = 1e-09
Identities = 29/80 (36%), Positives = 36/80 (45%), Gaps = 12/80 (15%)
Query: 198 DLPLPPGWSVDWTMRGRKYYIDHNTNTTHWSHPLER------------EGLPPGWERVES 245
+LPLP GW G+ YYIDH TT W P +R + LP GWE
Sbjct: 5 ELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWEEAYD 64
Query: 246 SEFGTYYVDHTNKKAQYRHP 265
+ G Y++DH K Q P
Sbjct: 65 PQVGDYFIDHNTKTTQIEDP 84
>gi|242247257 WW and C2 domain containing 1 isoform 2 [Homo sapiens]
Length = 1118
Score = 61.6 bits (148), Expect = 1e-09
Identities = 29/80 (36%), Positives = 36/80 (45%), Gaps = 12/80 (15%)
Query: 198 DLPLPPGWSVDWTMRGRKYYIDHNTNTTHWSHPLER------------EGLPPGWERVES 245
+LPLP GW G+ YYIDH TT W P +R + LP GWE
Sbjct: 5 ELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWEEAYD 64
Query: 246 SEFGTYYVDHTNKKAQYRHP 265
+ G Y++DH K Q P
Sbjct: 65 PQVGDYFIDHNTKTTQIEDP 84
>gi|242247251 WW and C2 domain containing 1 isoform 1 [Homo sapiens]
Length = 1119
Score = 61.6 bits (148), Expect = 1e-09
Identities = 29/80 (36%), Positives = 36/80 (45%), Gaps = 12/80 (15%)
Query: 198 DLPLPPGWSVDWTMRGRKYYIDHNTNTTHWSHPLER------------EGLPPGWERVES 245
+LPLP GW G+ YYIDH TT W P +R + LP GWE
Sbjct: 5 ELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWEEAYD 64
Query: 246 SEFGTYYVDHTNKKAQYRHP 265
+ G Y++DH K Q P
Sbjct: 65 PQVGDYFIDHNTKTTQIEDP 84
>gi|222352183 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 59.7 bits (143), Expect = 4e-09
Identities = 29/81 (35%), Positives = 39/81 (48%), Gaps = 16/81 (19%)
Query: 201 LPPGWSVDWTMRGRKYYIDHNTNTTHWS----------------HPLEREGLPPGWERVE 244
LPPGW + GR ++IDHNT TT W +P + LPPGWE
Sbjct: 378 LPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERI 437
Query: 245 SSEFGTYYVDHTNKKAQYRHP 265
+ T+Y+DH +K Q+ P
Sbjct: 438 HLDGRTFYIDHNSKITQWEDP 458
Score = 43.9 bits (102), Expect = 2e-04
Identities = 24/60 (40%), Positives = 29/60 (48%), Gaps = 1/60 (1%)
Query: 200 PLPPGWSVDWTMRGRKYYIDHNTNTTHWSHPLEREGLPPGWERVESSEFGTYYVDHTNKK 259
PLPPGW + GR +YIDHN+ T W P + G S EF Y D+ KK
Sbjct: 428 PLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY-DYFRKK 486
Score = 43.1 bits (100), Expect = 4e-04
Identities = 16/31 (51%), Positives = 18/31 (58%)
Query: 200 PLPPGWSVDWTMRGRKYYIDHNTNTTHWSHP 230
PLPPGW GR YY++HN TT W P
Sbjct: 73 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
Score = 40.0 bits (92), Expect = 0.004
Identities = 17/48 (35%), Positives = 24/48 (50%)
Query: 218 IDHNTNTTHWSHPLEREGLPPGWERVESSEFGTYYVDHTNKKAQYRHP 265
+D N + + L LPPGWE + TYYV+H N+ Q+ P
Sbjct: 56 VDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
Score = 39.7 bits (91), Expect = 0.005
Identities = 14/31 (45%), Positives = 19/31 (61%)
Query: 201 LPPGWSVDWTMRGRKYYIDHNTNTTHWSHPL 231
LP GW +GR YY++HN TT W+ P+
Sbjct: 266 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPI 296
Score = 35.0 bits (79), Expect = 0.11
Identities = 13/31 (41%), Positives = 19/31 (61%)
Query: 235 GLPPGWERVESSEFGTYYVDHTNKKAQYRHP 265
GLP GWE + ++ TYYV+H N+ + P
Sbjct: 265 GLPSGWEERKDAKGRTYYVNHNNRTTTWTRP 295
Score = 30.4 bits (67), Expect = 2.8
Identities = 12/43 (27%), Positives = 20/43 (46%)
Query: 223 NTTHWSHPLEREGLPPGWERVESSEFGTYYVDHTNKKAQYRHP 265
N+ H + + LPPGWE + +++DH K + P
Sbjct: 365 NSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDP 407
>gi|21361472 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 3 [Homo sapiens]
Length = 955
Score = 59.7 bits (143), Expect = 4e-09
Identities = 29/81 (35%), Positives = 39/81 (48%), Gaps = 16/81 (19%)
Query: 201 LPPGWSVDWTMRGRKYYIDHNTNTTHWS----------------HPLEREGLPPGWERVE 244
LPPGW + GR ++IDHNT TT W +P + LPPGWE
Sbjct: 479 LPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERI 538
Query: 245 SSEFGTYYVDHTNKKAQYRHP 265
+ T+Y+DH +K Q+ P
Sbjct: 539 HLDGRTFYIDHNSKITQWEDP 559
Score = 43.9 bits (102), Expect = 2e-04
Identities = 24/60 (40%), Positives = 29/60 (48%), Gaps = 1/60 (1%)
Query: 200 PLPPGWSVDWTMRGRKYYIDHNTNTTHWSHPLEREGLPPGWERVESSEFGTYYVDHTNKK 259
PLPPGW + GR +YIDHN+ T W P + G S EF Y D+ KK
Sbjct: 529 PLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY-DYFRKK 587
Score = 43.1 bits (100), Expect = 4e-04
Identities = 16/31 (51%), Positives = 18/31 (58%)
Query: 200 PLPPGWSVDWTMRGRKYYIDHNTNTTHWSHP 230
PLPPGW GR YY++HN TT W P
Sbjct: 194 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 224
Score = 40.0 bits (92), Expect = 0.004
Identities = 17/48 (35%), Positives = 24/48 (50%)
Query: 218 IDHNTNTTHWSHPLEREGLPPGWERVESSEFGTYYVDHTNKKAQYRHP 265
+D N + + L LPPGWE + TYYV+H N+ Q+ P
Sbjct: 177 VDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 224
Score = 39.7 bits (91), Expect = 0.005
Identities = 14/31 (45%), Positives = 19/31 (61%)
Query: 201 LPPGWSVDWTMRGRKYYIDHNTNTTHWSHPL 231
LP GW +GR YY++HN TT W+ P+
Sbjct: 367 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPI 397
Score = 35.0 bits (79), Expect = 0.11
Identities = 13/31 (41%), Positives = 19/31 (61%)
Query: 235 GLPPGWERVESSEFGTYYVDHTNKKAQYRHP 265
GLP GWE + ++ TYYV+H N+ + P
Sbjct: 366 GLPSGWEERKDAKGRTYYVNHNNRTTTWTRP 396
Score = 30.4 bits (67), Expect = 2.8
Identities = 12/43 (27%), Positives = 20/43 (46%)
Query: 223 NTTHWSHPLEREGLPPGWERVESSEFGTYYVDHTNKKAQYRHP 265
N+ H + + LPPGWE + +++DH K + P
Sbjct: 466 NSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDP 508
>gi|222352094 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 59.7 bits (143), Expect = 4e-09
Identities = 29/81 (35%), Positives = 39/81 (48%), Gaps = 16/81 (19%)
Query: 201 LPPGWSVDWTMRGRKYYIDHNTNTTHWS----------------HPLEREGLPPGWERVE 244
LPPGW + GR ++IDHNT TT W +P + LPPGWE
Sbjct: 358 LPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERI 417
Query: 245 SSEFGTYYVDHTNKKAQYRHP 265
+ T+Y+DH +K Q+ P
Sbjct: 418 HLDGRTFYIDHNSKITQWEDP 438
Score = 43.9 bits (102), Expect = 2e-04
Identities = 24/60 (40%), Positives = 29/60 (48%), Gaps = 1/60 (1%)
Query: 200 PLPPGWSVDWTMRGRKYYIDHNTNTTHWSHPLEREGLPPGWERVESSEFGTYYVDHTNKK 259
PLPPGW + GR +YIDHN+ T W P + G S EF Y D+ KK
Sbjct: 408 PLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY-DYFRKK 466
Score = 43.1 bits (100), Expect = 4e-04
Identities = 16/31 (51%), Positives = 18/31 (58%)
Query: 200 PLPPGWSVDWTMRGRKYYIDHNTNTTHWSHP 230
PLPPGW GR YY++HN TT W P
Sbjct: 73 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
Score = 40.0 bits (92), Expect = 0.004
Identities = 17/48 (35%), Positives = 24/48 (50%)
Query: 218 IDHNTNTTHWSHPLEREGLPPGWERVESSEFGTYYVDHTNKKAQYRHP 265
+D N + + L LPPGWE + TYYV+H N+ Q+ P
Sbjct: 56 VDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
Score = 39.7 bits (91), Expect = 0.005
Identities = 14/31 (45%), Positives = 19/31 (61%)
Query: 201 LPPGWSVDWTMRGRKYYIDHNTNTTHWSHPL 231
LP GW +GR YY++HN TT W+ P+
Sbjct: 246 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPI 276
Score = 35.0 bits (79), Expect = 0.11
Identities = 13/31 (41%), Positives = 19/31 (61%)
Query: 235 GLPPGWERVESSEFGTYYVDHTNKKAQYRHP 265
GLP GWE + ++ TYYV+H N+ + P
Sbjct: 245 GLPSGWEERKDAKGRTYYVNHNNRTTTWTRP 275
Score = 30.4 bits (67), Expect = 2.8
Identities = 12/43 (27%), Positives = 20/43 (46%)
Query: 223 NTTHWSHPLEREGLPPGWERVESSEFGTYYVDHTNKKAQYRHP 265
N+ H + + LPPGWE + +++DH K + P
Sbjct: 345 NSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDP 387
>gi|222352092 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 59.7 bits (143), Expect = 4e-09
Identities = 29/81 (35%), Positives = 39/81 (48%), Gaps = 16/81 (19%)
Query: 201 LPPGWSVDWTMRGRKYYIDHNTNTTHWS----------------HPLEREGLPPGWERVE 244
LPPGW + GR ++IDHNT TT W +P + LPPGWE
Sbjct: 358 LPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERI 417
Query: 245 SSEFGTYYVDHTNKKAQYRHP 265
+ T+Y+DH +K Q+ P
Sbjct: 418 HLDGRTFYIDHNSKITQWEDP 438
Score = 43.9 bits (102), Expect = 2e-04
Identities = 24/60 (40%), Positives = 29/60 (48%), Gaps = 1/60 (1%)
Query: 200 PLPPGWSVDWTMRGRKYYIDHNTNTTHWSHPLEREGLPPGWERVESSEFGTYYVDHTNKK 259
PLPPGW + GR +YIDHN+ T W P + G S EF Y D+ KK
Sbjct: 408 PLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY-DYFRKK 466
Score = 43.1 bits (100), Expect = 4e-04
Identities = 16/31 (51%), Positives = 18/31 (58%)
Query: 200 PLPPGWSVDWTMRGRKYYIDHNTNTTHWSHP 230
PLPPGW GR YY++HN TT W P
Sbjct: 73 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
Score = 40.0 bits (92), Expect = 0.004
Identities = 17/48 (35%), Positives = 24/48 (50%)
Query: 218 IDHNTNTTHWSHPLEREGLPPGWERVESSEFGTYYVDHTNKKAQYRHP 265
+D N + + L LPPGWE + TYYV+H N+ Q+ P
Sbjct: 56 VDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
Score = 39.7 bits (91), Expect = 0.005
Identities = 14/31 (45%), Positives = 19/31 (61%)
Query: 201 LPPGWSVDWTMRGRKYYIDHNTNTTHWSHPL 231
LP GW +GR YY++HN TT W+ P+
Sbjct: 246 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPI 276
Score = 35.0 bits (79), Expect = 0.11
Identities = 13/31 (41%), Positives = 19/31 (61%)
Query: 235 GLPPGWERVESSEFGTYYVDHTNKKAQYRHP 265
GLP GWE + ++ TYYV+H N+ + P
Sbjct: 245 GLPSGWEERKDAKGRTYYVNHNNRTTTWTRP 275
Score = 30.4 bits (67), Expect = 2.8
Identities = 12/43 (27%), Positives = 20/43 (46%)
Query: 223 NTTHWSHPLEREGLPPGWERVESSEFGTYYVDHTNKKAQYRHP 265
N+ H + + LPPGWE + +++DH K + P
Sbjct: 345 NSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDP 387
>gi|222352090 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 5 [Homo sapiens]
Length = 947
Score = 59.7 bits (143), Expect = 4e-09
Identities = 29/81 (35%), Positives = 39/81 (48%), Gaps = 16/81 (19%)
Query: 201 LPPGWSVDWTMRGRKYYIDHNTNTTHWS----------------HPLEREGLPPGWERVE 244
LPPGW + GR ++IDHNT TT W +P + LPPGWE
Sbjct: 471 LPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERI 530
Query: 245 SSEFGTYYVDHTNKKAQYRHP 265
+ T+Y+DH +K Q+ P
Sbjct: 531 HLDGRTFYIDHNSKITQWEDP 551
Score = 43.9 bits (102), Expect = 2e-04
Identities = 24/60 (40%), Positives = 29/60 (48%), Gaps = 1/60 (1%)
Query: 200 PLPPGWSVDWTMRGRKYYIDHNTNTTHWSHPLEREGLPPGWERVESSEFGTYYVDHTNKK 259
PLPPGW + GR +YIDHN+ T W P + G S EF Y D+ KK
Sbjct: 521 PLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY-DYFRKK 579
Score = 43.1 bits (100), Expect = 4e-04
Identities = 16/31 (51%), Positives = 18/31 (58%)
Query: 200 PLPPGWSVDWTMRGRKYYIDHNTNTTHWSHP 230
PLPPGW GR YY++HN TT W P
Sbjct: 186 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 216
Score = 40.0 bits (92), Expect = 0.004
Identities = 17/48 (35%), Positives = 24/48 (50%)
Query: 218 IDHNTNTTHWSHPLEREGLPPGWERVESSEFGTYYVDHTNKKAQYRHP 265
+D N + + L LPPGWE + TYYV+H N+ Q+ P
Sbjct: 169 VDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 216
Score = 39.7 bits (91), Expect = 0.005
Identities = 14/31 (45%), Positives = 19/31 (61%)
Query: 201 LPPGWSVDWTMRGRKYYIDHNTNTTHWSHPL 231
LP GW +GR YY++HN TT W+ P+
Sbjct: 359 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPI 389
Score = 35.0 bits (79), Expect = 0.11
Identities = 13/31 (41%), Positives = 19/31 (61%)
Query: 235 GLPPGWERVESSEFGTYYVDHTNKKAQYRHP 265
GLP GWE + ++ TYYV+H N+ + P
Sbjct: 358 GLPSGWEERKDAKGRTYYVNHNNRTTTWTRP 388
Score = 30.4 bits (67), Expect = 2.8
Identities = 12/43 (27%), Positives = 20/43 (46%)
Query: 223 NTTHWSHPLEREGLPPGWERVESSEFGTYYVDHTNKKAQYRHP 265
N+ H + + LPPGWE + +++DH K + P
Sbjct: 458 NSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDP 500
>gi|222352088 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 4 [Homo sapiens]
Length = 967
Score = 59.7 bits (143), Expect = 4e-09
Identities = 29/81 (35%), Positives = 39/81 (48%), Gaps = 16/81 (19%)
Query: 201 LPPGWSVDWTMRGRKYYIDHNTNTTHWS----------------HPLEREGLPPGWERVE 244
LPPGW + GR ++IDHNT TT W +P + LPPGWE
Sbjct: 491 LPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERI 550
Query: 245 SSEFGTYYVDHTNKKAQYRHP 265
+ T+Y+DH +K Q+ P
Sbjct: 551 HLDGRTFYIDHNSKITQWEDP 571
Score = 43.9 bits (102), Expect = 2e-04
Identities = 24/60 (40%), Positives = 29/60 (48%), Gaps = 1/60 (1%)
Query: 200 PLPPGWSVDWTMRGRKYYIDHNTNTTHWSHPLEREGLPPGWERVESSEFGTYYVDHTNKK 259
PLPPGW + GR +YIDHN+ T W P + G S EF Y D+ KK
Sbjct: 541 PLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY-DYFRKK 599
Score = 43.1 bits (100), Expect = 4e-04
Identities = 16/31 (51%), Positives = 18/31 (58%)
Query: 200 PLPPGWSVDWTMRGRKYYIDHNTNTTHWSHP 230
PLPPGW GR YY++HN TT W P
Sbjct: 186 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 216
Score = 40.0 bits (92), Expect = 0.004
Identities = 17/48 (35%), Positives = 24/48 (50%)
Query: 218 IDHNTNTTHWSHPLEREGLPPGWERVESSEFGTYYVDHTNKKAQYRHP 265
+D N + + L LPPGWE + TYYV+H N+ Q+ P
Sbjct: 169 VDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 216
Score = 39.7 bits (91), Expect = 0.005
Identities = 14/31 (45%), Positives = 19/31 (61%)
Query: 201 LPPGWSVDWTMRGRKYYIDHNTNTTHWSHPL 231
LP GW +GR YY++HN TT W+ P+
Sbjct: 379 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPI 409
Score = 35.0 bits (79), Expect = 0.11
Identities = 13/31 (41%), Positives = 19/31 (61%)
Query: 235 GLPPGWERVESSEFGTYYVDHTNKKAQYRHP 265
GLP GWE + ++ TYYV+H N+ + P
Sbjct: 378 GLPSGWEERKDAKGRTYYVNHNNRTTTWTRP 408
Score = 30.4 bits (67), Expect = 2.8
Identities = 12/43 (27%), Positives = 20/43 (46%)
Query: 223 NTTHWSHPLEREGLPPGWERVESSEFGTYYVDHTNKKAQYRHP 265
N+ H + + LPPGWE + +++DH K + P
Sbjct: 478 NSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDP 520
>gi|222352086 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 1 [Homo sapiens]
Length = 975
Score = 59.7 bits (143), Expect = 4e-09
Identities = 29/81 (35%), Positives = 39/81 (48%), Gaps = 16/81 (19%)
Query: 201 LPPGWSVDWTMRGRKYYIDHNTNTTHWS----------------HPLEREGLPPGWERVE 244
LPPGW + GR ++IDHNT TT W +P + LPPGWE
Sbjct: 499 LPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERI 558
Query: 245 SSEFGTYYVDHTNKKAQYRHP 265
+ T+Y+DH +K Q+ P
Sbjct: 559 HLDGRTFYIDHNSKITQWEDP 579
Score = 43.9 bits (102), Expect = 2e-04
Identities = 24/60 (40%), Positives = 29/60 (48%), Gaps = 1/60 (1%)
Query: 200 PLPPGWSVDWTMRGRKYYIDHNTNTTHWSHPLEREGLPPGWERVESSEFGTYYVDHTNKK 259
PLPPGW + GR +YIDHN+ T W P + G S EF Y D+ KK
Sbjct: 549 PLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY-DYFRKK 607
Score = 43.1 bits (100), Expect = 4e-04
Identities = 16/31 (51%), Positives = 18/31 (58%)
Query: 200 PLPPGWSVDWTMRGRKYYIDHNTNTTHWSHP 230
PLPPGW GR YY++HN TT W P
Sbjct: 194 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 224
Score = 40.0 bits (92), Expect = 0.004
Identities = 17/48 (35%), Positives = 24/48 (50%)
Query: 218 IDHNTNTTHWSHPLEREGLPPGWERVESSEFGTYYVDHTNKKAQYRHP 265
+D N + + L LPPGWE + TYYV+H N+ Q+ P
Sbjct: 177 VDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 224
Score = 39.7 bits (91), Expect = 0.005
Identities = 14/31 (45%), Positives = 19/31 (61%)
Query: 201 LPPGWSVDWTMRGRKYYIDHNTNTTHWSHPL 231
LP GW +GR YY++HN TT W+ P+
Sbjct: 387 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPI 417
Score = 35.0 bits (79), Expect = 0.11
Identities = 13/31 (41%), Positives = 19/31 (61%)
Query: 235 GLPPGWERVESSEFGTYYVDHTNKKAQYRHP 265
GLP GWE + ++ TYYV+H N+ + P
Sbjct: 386 GLPSGWEERKDAKGRTYYVNHNNRTTTWTRP 416
Score = 30.4 bits (67), Expect = 2.8
Identities = 12/43 (27%), Positives = 20/43 (46%)
Query: 223 NTTHWSHPLEREGLPPGWERVESSEFGTYYVDHTNKKAQYRHP 265
N+ H + + LPPGWE + +++DH K + P
Sbjct: 486 NSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDP 528
>gi|222352084 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 59.7 bits (143), Expect = 4e-09
Identities = 29/81 (35%), Positives = 39/81 (48%), Gaps = 16/81 (19%)
Query: 201 LPPGWSVDWTMRGRKYYIDHNTNTTHWS----------------HPLEREGLPPGWERVE 244
LPPGW + GR ++IDHNT TT W +P + LPPGWE
Sbjct: 378 LPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERI 437
Query: 245 SSEFGTYYVDHTNKKAQYRHP 265
+ T+Y+DH +K Q+ P
Sbjct: 438 HLDGRTFYIDHNSKITQWEDP 458
Score = 43.9 bits (102), Expect = 2e-04
Identities = 24/60 (40%), Positives = 29/60 (48%), Gaps = 1/60 (1%)
Query: 200 PLPPGWSVDWTMRGRKYYIDHNTNTTHWSHPLEREGLPPGWERVESSEFGTYYVDHTNKK 259
PLPPGW + GR +YIDHN+ T W P + G S EF Y D+ KK
Sbjct: 428 PLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY-DYFRKK 486
Score = 43.1 bits (100), Expect = 4e-04
Identities = 16/31 (51%), Positives = 18/31 (58%)
Query: 200 PLPPGWSVDWTMRGRKYYIDHNTNTTHWSHP 230
PLPPGW GR YY++HN TT W P
Sbjct: 73 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
Score = 40.0 bits (92), Expect = 0.004
Identities = 17/48 (35%), Positives = 24/48 (50%)
Query: 218 IDHNTNTTHWSHPLEREGLPPGWERVESSEFGTYYVDHTNKKAQYRHP 265
+D N + + L LPPGWE + TYYV+H N+ Q+ P
Sbjct: 56 VDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
Score = 39.7 bits (91), Expect = 0.005
Identities = 14/31 (45%), Positives = 19/31 (61%)
Query: 201 LPPGWSVDWTMRGRKYYIDHNTNTTHWSHPL 231
LP GW +GR YY++HN TT W+ P+
Sbjct: 266 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPI 296
Score = 35.0 bits (79), Expect = 0.11
Identities = 13/31 (41%), Positives = 19/31 (61%)
Query: 235 GLPPGWERVESSEFGTYYVDHTNKKAQYRHP 265
GLP GWE + ++ TYYV+H N+ + P
Sbjct: 265 GLPSGWEERKDAKGRTYYVNHNNRTTTWTRP 295
Score = 30.4 bits (67), Expect = 2.8
Identities = 12/43 (27%), Positives = 20/43 (46%)
Query: 223 NTTHWSHPLEREGLPPGWERVESSEFGTYYVDHTNKKAQYRHP 265
N+ H + + LPPGWE + +++DH K + P
Sbjct: 365 NSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDP 407
>gi|222352082 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 59.7 bits (143), Expect = 4e-09
Identities = 29/81 (35%), Positives = 39/81 (48%), Gaps = 16/81 (19%)
Query: 201 LPPGWSVDWTMRGRKYYIDHNTNTTHWS----------------HPLEREGLPPGWERVE 244
LPPGW + GR ++IDHNT TT W +P + LPPGWE
Sbjct: 378 LPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERI 437
Query: 245 SSEFGTYYVDHTNKKAQYRHP 265
+ T+Y+DH +K Q+ P
Sbjct: 438 HLDGRTFYIDHNSKITQWEDP 458
Score = 43.9 bits (102), Expect = 2e-04
Identities = 24/60 (40%), Positives = 29/60 (48%), Gaps = 1/60 (1%)
Query: 200 PLPPGWSVDWTMRGRKYYIDHNTNTTHWSHPLEREGLPPGWERVESSEFGTYYVDHTNKK 259
PLPPGW + GR +YIDHN+ T W P + G S EF Y D+ KK
Sbjct: 428 PLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY-DYFRKK 486
Score = 43.1 bits (100), Expect = 4e-04
Identities = 16/31 (51%), Positives = 18/31 (58%)
Query: 200 PLPPGWSVDWTMRGRKYYIDHNTNTTHWSHP 230
PLPPGW GR YY++HN TT W P
Sbjct: 73 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
Score = 40.0 bits (92), Expect = 0.004
Identities = 17/48 (35%), Positives = 24/48 (50%)
Query: 218 IDHNTNTTHWSHPLEREGLPPGWERVESSEFGTYYVDHTNKKAQYRHP 265
+D N + + L LPPGWE + TYYV+H N+ Q+ P
Sbjct: 56 VDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
Score = 39.7 bits (91), Expect = 0.005
Identities = 14/31 (45%), Positives = 19/31 (61%)
Query: 201 LPPGWSVDWTMRGRKYYIDHNTNTTHWSHPL 231
LP GW +GR YY++HN TT W+ P+
Sbjct: 266 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPI 296
Score = 35.0 bits (79), Expect = 0.11
Identities = 13/31 (41%), Positives = 19/31 (61%)
Query: 235 GLPPGWERVESSEFGTYYVDHTNKKAQYRHP 265
GLP GWE + ++ TYYV+H N+ + P
Sbjct: 265 GLPSGWEERKDAKGRTYYVNHNNRTTTWTRP 295
Score = 30.4 bits (67), Expect = 2.8
Identities = 12/43 (27%), Positives = 20/43 (46%)
Query: 223 NTTHWSHPLEREGLPPGWERVESSEFGTYYVDHTNKKAQYRHP 265
N+ H + + LPPGWE + +++DH K + P
Sbjct: 365 NSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDP 407
>gi|7706523 WW domain-containing oxidoreductase isoform 1 [Homo
sapiens]
Length = 414
Score = 58.2 bits (139), Expect = 1e-08
Identities = 32/89 (35%), Positives = 40/89 (44%), Gaps = 7/89 (7%)
Query: 183 VAATSLGNLTNHGSEDLPLPPGWSVDWTMRGRKYYIDHNTNTTHWSHPLERE------GL 236
+AA L + SED LPPGW T G YY +H T W HP + L
Sbjct: 1 MAALRYAGLDDTDSED-ELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDL 59
Query: 237 PPGWERVESSEFGTYYVDHTNKKAQYRHP 265
P GWE+ ++VDH NK+ Y P
Sbjct: 60 PYGWEQETDENGQVFFVDHINKRTTYLDP 88
Score = 41.6 bits (96), Expect = 0.001
Identities = 19/59 (32%), Positives = 27/59 (45%)
Query: 236 LPPGWERVESSEFGTYYVDHTNKKAQYRHPCAPSVPRYDQPPPVTYQPQQTERNQSLLV 294
LPPGWE + + YY +HT +K Q+ HP R P ++ + E Q V
Sbjct: 18 LPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDENGQVFFV 76
>gi|18860884 WW domain-containing oxidoreductase isoform 2 [Homo
sapiens]
Length = 189
Score = 58.2 bits (139), Expect = 1e-08
Identities = 32/89 (35%), Positives = 40/89 (44%), Gaps = 7/89 (7%)
Query: 183 VAATSLGNLTNHGSEDLPLPPGWSVDWTMRGRKYYIDHNTNTTHWSHPLERE------GL 236
+AA L + SED LPPGW T G YY +H T W HP + L
Sbjct: 1 MAALRYAGLDDTDSED-ELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDL 59
Query: 237 PPGWERVESSEFGTYYVDHTNKKAQYRHP 265
P GWE+ ++VDH NK+ Y P
Sbjct: 60 PYGWEQETDENGQVFFVDHINKRTTYLDP 88
Score = 41.6 bits (96), Expect = 0.001
Identities = 19/59 (32%), Positives = 27/59 (45%)
Query: 236 LPPGWERVESSEFGTYYVDHTNKKAQYRHPCAPSVPRYDQPPPVTYQPQQTERNQSLLV 294
LPPGWE + + YY +HT +K Q+ HP R P ++ + E Q V
Sbjct: 18 LPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDENGQVFFV 76
>gi|114520609 neural precursor cell expressed, developmentally
down-regulated 4 isoform 1 [Homo sapiens]
Length = 900
Score = 55.5 bits (132), Expect = 8e-08
Identities = 27/82 (32%), Positives = 37/82 (45%), Gaps = 17/82 (20%)
Query: 201 LPPGWSVDWTMRGRKYYIDHNTNTTHWSHPL-----------------EREGLPPGWERV 243
LP GW V GR ++IDHNT TT W P + LPPGWE
Sbjct: 423 LPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPLPPGWEER 482
Query: 244 ESSEFGTYYVDHTNKKAQYRHP 265
++ +Y++H K+ Q+ P
Sbjct: 483 THTDGRIFYINHNIKRTQWEDP 504
Score = 48.9 bits (115), Expect = 8e-06
Identities = 27/103 (26%), Positives = 37/103 (35%), Gaps = 38/103 (36%)
Query: 201 LPPGWSVDWTMRGRKYYIDHNTNTTHWSHP------------------------------ 230
LPPGW RGR YY+DHN+ TT W+ P
Sbjct: 350 LPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQSSAGPQSQASTSDSG 409
Query: 231 --------LEREGLPPGWERVESSEFGTYYVDHTNKKAQYRHP 265
+E+ LP GWE + +++DH K + P
Sbjct: 410 QQVTQPSEIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDP 452
Score = 43.5 bits (101), Expect = 3e-04
Identities = 36/131 (27%), Positives = 52/131 (39%), Gaps = 15/131 (11%)
Query: 140 FDGQRKRPLGDRAHEDYRYYE-YNHDLFQRMPQNQGRHASGIGRVAATSL----GNLTNH 194
F GQ PL E+ R Y F P++ G R+ T L G+ ++
Sbjct: 102 FLGQVDVPLYPLPTENPRLERPYTFKDFVLHPRSHKSRVKGYLRLKMTYLPKTSGSEDDN 161
Query: 195 GSEDLPLPPGWSVDWTMRGRKYYIDHNTNTTHWSHPLEREGLPPGWERVESSEFGTYYVD 254
+ L PGW V +D H E LPPGWE + TYYV+
Sbjct: 162 AEQAEELEPGWVV----------LDQPDAACHLQQQQEPSPLPPGWEERQDILGRTYYVN 211
Query: 255 HTNKKAQYRHP 265
H +++ Q++ P
Sbjct: 212 HESRRTQWKRP 222
Score = 43.1 bits (100), Expect = 4e-04
Identities = 16/40 (40%), Positives = 22/40 (55%)
Query: 197 EDLPLPPGWSVDWTMRGRKYYIDHNTNTTHWSHPLEREGL 236
E PLPPGW + GR YY++H + T W P ++ L
Sbjct: 189 EPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNL 228
Score = 40.0 bits (92), Expect = 0.004
Identities = 20/50 (40%), Positives = 25/50 (50%), Gaps = 1/50 (2%)
Query: 182 RVAATSLGNLTNHGSEDL-PLPPGWSVDWTMRGRKYYIDHNTNTTHWSHP 230
++ A G + S DL PLPPGW GR +YI+HN T W P
Sbjct: 455 KIPAHLRGKTSLDTSNDLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDP 504
Score = 36.2 bits (82), Expect = 0.051
Identities = 13/31 (41%), Positives = 18/31 (58%)
Query: 235 GLPPGWERVESSEFGTYYVDHTNKKAQYRHP 265
GLPPGWE + +YYVDH ++ + P
Sbjct: 349 GLPPGWEEKQDERGRSYYVDHNSRTTTWTKP 379
>gi|114520607 neural precursor cell expressed, developmentally
down-regulated 4 isoform 2 [Homo sapiens]
Length = 1247
Score = 55.5 bits (132), Expect = 8e-08
Identities = 27/82 (32%), Positives = 37/82 (45%), Gaps = 17/82 (20%)
Query: 201 LPPGWSVDWTMRGRKYYIDHNTNTTHWSHPL-----------------EREGLPPGWERV 243
LP GW V GR ++IDHNT TT W P + LPPGWE
Sbjct: 770 LPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPLPPGWEER 829
Query: 244 ESSEFGTYYVDHTNKKAQYRHP 265
++ +Y++H K+ Q+ P
Sbjct: 830 THTDGRIFYINHNIKRTQWEDP 851
Score = 48.9 bits (115), Expect = 8e-06
Identities = 27/103 (26%), Positives = 37/103 (35%), Gaps = 38/103 (36%)
Query: 201 LPPGWSVDWTMRGRKYYIDHNTNTTHWSHP------------------------------ 230
LPPGW RGR YY+DHN+ TT W+ P
Sbjct: 697 LPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQSSAGPQSQASTSDSG 756
Query: 231 --------LEREGLPPGWERVESSEFGTYYVDHTNKKAQYRHP 265
+E+ LP GWE + +++DH K + P
Sbjct: 757 QQVTQPSEIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDP 799
Score = 43.1 bits (100), Expect = 4e-04
Identities = 16/40 (40%), Positives = 22/40 (55%)
Query: 197 EDLPLPPGWSVDWTMRGRKYYIDHNTNTTHWSHPLEREGL 236
E PLPPGW + GR YY++H + T W P ++ L
Sbjct: 536 EPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNL 575
Score = 40.0 bits (92), Expect = 0.004
Identities = 20/63 (31%), Positives = 28/63 (44%), Gaps = 10/63 (15%)
Query: 203 PGWSVDWTMRGRKYYIDHNTNTTHWSHPLEREGLPPGWERVESSEFGTYYVDHTNKKAQY 262
PGW V +D H E LPPGWE + TYYV+H +++ Q+
Sbjct: 517 PGWVV----------LDQPDAACHLQQQQEPSPLPPGWEERQDILGRTYYVNHESRRTQW 566
Query: 263 RHP 265
+ P
Sbjct: 567 KRP 569
Score = 40.0 bits (92), Expect = 0.004
Identities = 20/50 (40%), Positives = 25/50 (50%), Gaps = 1/50 (2%)
Query: 182 RVAATSLGNLTNHGSEDL-PLPPGWSVDWTMRGRKYYIDHNTNTTHWSHP 230
++ A G + S DL PLPPGW GR +YI+HN T W P
Sbjct: 802 KIPAHLRGKTSLDTSNDLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDP 851
Score = 36.2 bits (82), Expect = 0.051
Identities = 13/31 (41%), Positives = 18/31 (58%)
Query: 235 GLPPGWERVESSEFGTYYVDHTNKKAQYRHP 265
GLPPGWE + +YYVDH ++ + P
Sbjct: 696 GLPPGWEEKQDERGRSYYVDHNSRTTTWTKP 726
>gi|194306653 Yes-associated protein 1, 65kDa isoform 1 [Homo
sapiens]
Length = 504
Score = 53.5 bits (127), Expect = 3e-07
Identities = 33/124 (26%), Positives = 50/124 (40%), Gaps = 36/124 (29%)
Query: 197 EDLPLPPGWSVDWTMRGRKYYIDHNTNTTHWSHPLE------------------------ 232
+D+PLP GW + T G++Y+++H TT W P +
Sbjct: 169 DDVPLPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSA 228
Query: 233 REGLPPGWERVESSEFGTYYVDHTNKKAQYRHP-----------CAPSVPRYDQPPPVTY 281
LP GWE+ + + YY++H NK + P + S P QPPP+
Sbjct: 229 SGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFAMNQRISQSAP-VKQPPPLAP 287
Query: 282 QPQQ 285
Q Q
Sbjct: 288 QSPQ 291
Score = 30.0 bits (66), Expect = 3.6
Identities = 13/56 (23%), Positives = 27/56 (48%)
Query: 236 LPPGWERVESSEFGTYYVDHTNKKAQYRHPCAPSVPRYDQPPPVTYQPQQTERNQS 291
LP GWE ++S Y+++H ++ ++ P + + + P + QQ N +
Sbjct: 173 LPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSA 228
>gi|19923493 pleckstrin homology domain containing, family A member
5 isoform 1 [Homo sapiens]
Length = 1116
Score = 53.1 bits (126), Expect = 4e-07
Identities = 25/80 (31%), Positives = 37/80 (46%), Gaps = 11/80 (13%)
Query: 197 EDLPLPPGWSVDWTMRGRKYYIDHNTNTTHWSHPLEREG-----------LPPGWERVES 245
E + LP W+ T GR ++I+ +T W HP+ E LP GWE +
Sbjct: 8 EWISLPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTGHRRQSTDLPTGWEEAYT 67
Query: 246 SEFGTYYVDHTNKKAQYRHP 265
E YY++H +K +HP
Sbjct: 68 FEGARYYINHNERKVTCKHP 87
Score = 39.7 bits (91), Expect = 0.005
Identities = 15/41 (36%), Positives = 21/41 (51%)
Query: 191 LTNHGSEDLPLPPGWSVDWTMRGRKYYIDHNTNTTHWSHPL 231
+T H + LP GW +T G +YYI+HN HP+
Sbjct: 48 VTGHRRQSTDLPTGWEEAYTFEGARYYINHNERKVTCKHPV 88
>gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [Homo
sapiens]
Length = 731
Score = 51.6 bits (122), Expect = 1e-06
Identities = 40/145 (27%), Positives = 62/145 (42%), Gaps = 22/145 (15%)
Query: 194 HGSEDLPLPPGWSVDWTMRGRKYYIDHNTNTTHWSHPL-----------EREGLPPGWER 242
HG + LP G+ T++G+ Y++ T + W P E LPPGWE
Sbjct: 229 HGHQSPELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPRDLNSVNCDELGPLPPGWEV 288
Query: 243 VESSEFGTYYVDHTNKKAQYRHPCAPSVPRYDQPPPVTYQPQQTERNQSLLVPA-NPYHT 301
+ Y+VDH N+ Q+ P + + +Q Q E +Q L +P+
Sbjct: 289 RSTVSGRIYFVDHNNRTTQFTDPRLHHI--------MNHQCQLKEPSQPLPLPSEGSLED 340
Query: 302 AEIPDWLQVYARAPVKYDHILKWEL 326
E+P Q Y R V+ +L+ EL
Sbjct: 341 EELP--AQRYERDLVQKLKVLRHEL 363
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.133 0.410
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,339,550
Number of Sequences: 37866
Number of extensions: 811796
Number of successful extensions: 2749
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 61
Number of HSP's successfully gapped in prelim test: 22
Number of HSP's that attempted gapping in prelim test: 2482
Number of HSP's gapped (non-prelim): 221
length of query: 383
length of database: 18,247,518
effective HSP length: 104
effective length of query: 279
effective length of database: 14,309,454
effective search space: 3992337666
effective search space used: 3992337666
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.