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Search of human proteins with 169207319
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|169207319 PREDICTED: hypothetical protein [Homo sapiens]
(828 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|169207319 PREDICTED: hypothetical protein [Homo sapiens] 1596 0.0
gi|169207756 PREDICTED: hypothetical protein [Homo sapiens] 1594 0.0
gi|169207046 PREDICTED: hypothetical protein [Homo sapiens] 1594 0.0
gi|55770834 centromere protein F [Homo sapiens] 105 2e-22
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 99 2e-20
gi|71061468 centromere protein E [Homo sapiens] 98 4e-20
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 96 1e-19
gi|21735548 centrosomal protein 2 [Homo sapiens] 96 1e-19
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 96 1e-19
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 96 2e-19
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 96 2e-19
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 95 2e-19
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 95 3e-19
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 94 7e-19
gi|156104908 myosin heavy chain 6 [Homo sapiens] 94 7e-19
gi|33946313 ninein isoform 4 [Homo sapiens] 94 7e-19
gi|33946321 ninein isoform 5 [Homo sapiens] 94 7e-19
gi|148536871 ninein isoform 1 [Homo sapiens] 94 7e-19
gi|148536869 ninein isoform 2 [Homo sapiens] 94 7e-19
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 93 1e-18
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 92 2e-18
gi|221219020 NYD-SP11 protein [Homo sapiens] 92 2e-18
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap... 92 3e-18
gi|118498356 kinectin 1 isoform a [Homo sapiens] 91 6e-18
gi|33620775 kinectin 1 isoform a [Homo sapiens] 91 6e-18
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 91 6e-18
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 90 7e-18
gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens] 90 1e-17
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 90 1e-17
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 89 2e-17
>gi|169207319 PREDICTED: hypothetical protein [Homo sapiens]
Length = 828
Score = 1596 bits (4132), Expect = 0.0
Identities = 828/828 (100%), Positives = 828/828 (100%)
Query: 1 MALSPWTPGLGAGEKLVQAAAVSTGPSLELCTLPSTLGSSVAVEALEQLFVVEQSLQSDY 60
MALSPWTPGLGAGEKLVQAAAVSTGPSLELCTLPSTLGSSVAVEALEQLFVVEQSLQSDY
Sbjct: 1 MALSPWTPGLGAGEKLVQAAAVSTGPSLELCTLPSTLGSSVAVEALEQLFVVEQSLQSDY 60
Query: 61 FKCNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEEC 120
FKCNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEEC
Sbjct: 61 FKCNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEEC 120
Query: 121 VRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFVLS 180
VRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFVLS
Sbjct: 121 VRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFVLS 180
Query: 181 LNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQ 240
LNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQ
Sbjct: 181 LNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQ 240
Query: 241 INEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYW 300
INEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYW
Sbjct: 241 INEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYW 300
Query: 301 EQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDL 360
EQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDL
Sbjct: 301 EQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDL 360
Query: 361 REKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGL 420
REKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGL
Sbjct: 361 REKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGL 420
Query: 421 ITLQELQQATKTVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAI 480
ITLQELQQATKTVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAI
Sbjct: 421 ITLQELQQATKTVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAI 480
Query: 481 TEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSKY 540
TEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSKY
Sbjct: 481 TEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSKY 540
Query: 541 EEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHI 600
EEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHI
Sbjct: 541 EEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHI 600
Query: 601 FLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNLENGFYINDQKADLLLLEN 660
FLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNLENGFYINDQKADLLLLEN
Sbjct: 601 FLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNLENGFYINDQKADLLLLEN 660
Query: 661 KKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTTVKILVDNG 720
KKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTTVKILVDNG
Sbjct: 661 KKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTTVKILVDNG 720
Query: 721 EETLQDINNLTDKLRERDEKMQHVSTWLRGSLEGLRLLVEQESPMDLLSKQQLRALLVTS 780
EETLQDINNLTDKLRERDEKMQHVSTWLRGSLEGLRLLVEQESPMDLLSKQQLRALLVTS
Sbjct: 721 EETLQDINNLTDKLRERDEKMQHVSTWLRGSLEGLRLLVEQESPMDLLSKQQLRALLVTS 780
Query: 781 KEEKTCQLSDLVIPNYATNIQLNIDTYLGLNTLVVLSNSAFHLREFSR 828
KEEKTCQLSDLVIPNYATNIQLNIDTYLGLNTLVVLSNSAFHLREFSR
Sbjct: 781 KEEKTCQLSDLVIPNYATNIQLNIDTYLGLNTLVVLSNSAFHLREFSR 828
>gi|169207756 PREDICTED: hypothetical protein [Homo sapiens]
Length = 828
Score = 1594 bits (4127), Expect = 0.0
Identities = 827/828 (99%), Positives = 828/828 (100%)
Query: 1 MALSPWTPGLGAGEKLVQAAAVSTGPSLELCTLPSTLGSSVAVEALEQLFVVEQSLQSDY 60
MALSPWTPGLGAGEKLVQAAAVSTGPSLELCTLPSTLGSSVAVEALEQLFVVEQSLQSDY
Sbjct: 1 MALSPWTPGLGAGEKLVQAAAVSTGPSLELCTLPSTLGSSVAVEALEQLFVVEQSLQSDY 60
Query: 61 FKCNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEEC 120
FKCNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEEC
Sbjct: 61 FKCNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEEC 120
Query: 121 VRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFVLS 180
VRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFVLS
Sbjct: 121 VRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFVLS 180
Query: 181 LNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQ 240
LNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQ
Sbjct: 181 LNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQ 240
Query: 241 INEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYW 300
INEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYW
Sbjct: 241 INEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYW 300
Query: 301 EQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDL 360
EQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDL
Sbjct: 301 EQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDL 360
Query: 361 REKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGL 420
REKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGL
Sbjct: 361 REKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGL 420
Query: 421 ITLQELQQATKTVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAI 480
ITLQELQQATKTVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAI
Sbjct: 421 ITLQELQQATKTVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAI 480
Query: 481 TEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSKY 540
TEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSKY
Sbjct: 481 TEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSKY 540
Query: 541 EEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHI 600
EEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHI
Sbjct: 541 EEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHI 600
Query: 601 FLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNLENGFYINDQKADLLLLEN 660
FLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNLENGFYINDQKADLLLLEN
Sbjct: 601 FLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNLENGFYINDQKADLLLLEN 660
Query: 661 KKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTTVKILVDNG 720
KKLKEYILYLKNNIEKYREGQEALMHTS+DLSRQLIAQEAQYKDLWAEFQTTVKILVDNG
Sbjct: 661 KKLKEYILYLKNNIEKYREGQEALMHTSSDLSRQLIAQEAQYKDLWAEFQTTVKILVDNG 720
Query: 721 EETLQDINNLTDKLRERDEKMQHVSTWLRGSLEGLRLLVEQESPMDLLSKQQLRALLVTS 780
EETLQDINNLTDKLRERDEKMQHVSTWLRGSLEGLRLLVEQESPMDLLSKQQLRALLVTS
Sbjct: 721 EETLQDINNLTDKLRERDEKMQHVSTWLRGSLEGLRLLVEQESPMDLLSKQQLRALLVTS 780
Query: 781 KEEKTCQLSDLVIPNYATNIQLNIDTYLGLNTLVVLSNSAFHLREFSR 828
KEEKTCQLSDLVIPNYATNIQLNIDTYLGLNTLVVLSNSAFHLREFSR
Sbjct: 781 KEEKTCQLSDLVIPNYATNIQLNIDTYLGLNTLVVLSNSAFHLREFSR 828
>gi|169207046 PREDICTED: hypothetical protein [Homo sapiens]
Length = 828
Score = 1594 bits (4127), Expect = 0.0
Identities = 827/828 (99%), Positives = 828/828 (100%)
Query: 1 MALSPWTPGLGAGEKLVQAAAVSTGPSLELCTLPSTLGSSVAVEALEQLFVVEQSLQSDY 60
MALSPWTPGLGAGEKLVQAAAVSTGPSLELCTLPSTLGSSVAVEALEQLFVVEQSLQSDY
Sbjct: 1 MALSPWTPGLGAGEKLVQAAAVSTGPSLELCTLPSTLGSSVAVEALEQLFVVEQSLQSDY 60
Query: 61 FKCNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEEC 120
FKCNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEEC
Sbjct: 61 FKCNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEEC 120
Query: 121 VRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFVLS 180
VRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFVLS
Sbjct: 121 VRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFVLS 180
Query: 181 LNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQ 240
LNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQ
Sbjct: 181 LNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQ 240
Query: 241 INEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYW 300
INEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYW
Sbjct: 241 INEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYW 300
Query: 301 EQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDL 360
EQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDL
Sbjct: 301 EQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDL 360
Query: 361 REKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGL 420
REKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGL
Sbjct: 361 REKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGL 420
Query: 421 ITLQELQQATKTVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAI 480
ITLQELQQATKTVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAI
Sbjct: 421 ITLQELQQATKTVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAI 480
Query: 481 TEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSKY 540
TEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSKY
Sbjct: 481 TEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSKY 540
Query: 541 EEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHI 600
EEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHI
Sbjct: 541 EEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHI 600
Query: 601 FLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNLENGFYINDQKADLLLLEN 660
FLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNLENGFYINDQKADLLLLEN
Sbjct: 601 FLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNLENGFYINDQKADLLLLEN 660
Query: 661 KKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTTVKILVDNG 720
KKLKEYILYLKNNIEKYREGQEALMHTS+DLSRQLIAQEAQYKDLWAEFQTTVKILVDNG
Sbjct: 661 KKLKEYILYLKNNIEKYREGQEALMHTSSDLSRQLIAQEAQYKDLWAEFQTTVKILVDNG 720
Query: 721 EETLQDINNLTDKLRERDEKMQHVSTWLRGSLEGLRLLVEQESPMDLLSKQQLRALLVTS 780
EETLQDINNLTDKLRERDEKMQHVSTWLRGSLEGLRLLVEQESPMDLLSKQQLRALLVTS
Sbjct: 721 EETLQDINNLTDKLRERDEKMQHVSTWLRGSLEGLRLLVEQESPMDLLSKQQLRALLVTS 780
Query: 781 KEEKTCQLSDLVIPNYATNIQLNIDTYLGLNTLVVLSNSAFHLREFSR 828
KEEKTCQLSDLVIPNYATNIQLNIDTYLGLNTLVVLSNSAFHLREFSR
Sbjct: 781 KEEKTCQLSDLVIPNYATNIQLNIDTYLGLNTLVVLSNSAFHLREFSR 828
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 105 bits (262), Expect = 2e-22
Identities = 160/740 (21%), Positives = 320/740 (43%), Gaps = 87/740 (11%)
Query: 79 KKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEECVRDARRLNLFEINTIKMR 138
++LE + + +++ E+ + LL+TL + + L++ +L E ++ +
Sbjct: 1989 QELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALS 2048
Query: 139 ITRTE--NEIELLKKKITDLTKYNEALGEKQEELARKHARFVLSLNQTMEKKATTTVYIN 196
+T+ E N+I L K+ L K +E+L + E + +L + +K + ++
Sbjct: 2049 LTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLS 2108
Query: 197 ETYTKINLKREDI--------ALQKKCIQEAEELMEKERAEYLIRK--QELTAQINEFEN 246
T +++ R I A +KK + AE+L E+ER ++ + L ++ E
Sbjct: 2109 STQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEE 2168
Query: 247 TREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSE 306
+E+ ++ K E++ L+T++ ++ ++ V L E L + I+ + ++SE
Sbjct: 2169 NQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSE 2228
Query: 307 LKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKT 366
L K L+ ++ L + KE+ + +E K VE L + + K+L E +
Sbjct: 2229 LDKLLSSFKSLL----EEKEQAEIQIKEES-------KTAVEML---QNQLKELNEAVAA 2274
Query: 367 LARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLITLQEL 426
L +I+ + E+ I +E+Q + + E ++ D K L LQ+L
Sbjct: 2275 LCGDQEIMKATEQSL---DPPIEEEHQLRNSI----EKLRARLEADEKKQ---LCVLQQL 2324
Query: 427 QQATKTVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAITEKIQN 486
+++ + +K NLERE + Q A + +KA+I+ +T+ ++
Sbjct: 2325 KESEH--HADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRG 2382
Query: 487 AEV-------RRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSK 539
E+ + L NE Q+ IS L+E+E+ EK+ MKE S
Sbjct: 2383 LELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQ-----EKVQMKEKSS 2437
Query: 540 YEEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQE-----ED 594
+ + +TQ+ +EL E + L ++ K K + L + ++ + ++
Sbjct: 2438 -TAMEMLQTQL-----KELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDE 2491
Query: 595 LLNNHIFLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNLENGFYINDQKAD 654
NN+I L + + I +ED KQ+L++ +D+E + K+ + + L + K
Sbjct: 2492 AKNNYIVLQS-SVNGLIQEVEDGKQKLEK-KDEEISRLKNQIQDQEQLVS-------KLS 2542
Query: 655 LLLLENKKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTT-- 712
+ E++ KE L L+N + + + L + L L ++ YK+L E + T
Sbjct: 2543 QVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKM 2602
Query: 713 --------VKILVDNGEETLQDINNLTDKLRERDEKMQHVSTWLRGSLEGLRLLVEQESP 764
V + E ++++ + K E E++ L G L+ LL+E+
Sbjct: 2603 DKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQ---LLLEEIKS 2659
Query: 765 MDLLSKQQLRALLVTSKEEK 784
SK QL+ L + + E K
Sbjct: 2660 ----SKDQLKELTLENSELK 2675
Score = 77.8 bits (190), Expect = 4e-14
Identities = 103/528 (19%), Positives = 243/528 (46%), Gaps = 71/528 (13%)
Query: 71 LKDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEECVR------DA 124
L+ + + V + ++ + L+ E +++L + + N ++ + +E V+ A
Sbjct: 2380 LRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTA 2439
Query: 125 RRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELAR-----KHARFVL 179
+ ++ + R+ N+ E K K +L+ E L ++ +L + K+ VL
Sbjct: 2440 MEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVL 2499
Query: 180 --SLNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQEL 237
S+N +++ + + K+ K E+I+ K IQ+ E+L+ K + + E
Sbjct: 2500 QSSVNGLIQE-------VEDGKQKLEKKDEEISRLKNQIQDQEQLVSK------LSQVEG 2546
Query: 238 TAQINEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTV--SAAVLSDHNLEIARLHE 295
Q+ + +N E++ + T + ++++ LQ+K + +++T+ V S+ ++ LE+ ++ +
Sbjct: 2547 EHQLWKEQNL-ELRNL-TVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDK 2604
Query: 296 SIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARM 355
+ ++V+++ L+ ++ +L + + EKN +++ L+E + +++
Sbjct: 2605 MS--FVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKD 2662
Query: 356 EYKDL---------------------REKMKTLARQYKIVLSEEEKA----FLQKQKIHD 390
+ K+L K++ +Y++ L E EK L K ++
Sbjct: 2663 QLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYE 2722
Query: 391 -ENQKQLTFISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSANLERES 449
E Q ++ KE LS ++++I ++ L +AT + ++ K NL+ +
Sbjct: 2723 VEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVN 2782
Query: 450 QRCVITQWKMACLRKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFV 509
Q L+K++ R K+K I++ + + E+ + EL + ++++ +G V
Sbjct: 2783 Q-----------LKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTV 2831
Query: 510 --AQIEKLTTELKEEEKAFVNKEKMLMKELSKYEEIFVKETQINKEKE 555
++++LTTE+KE ++ K K + L KY + + ++ K KE
Sbjct: 2832 MDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKE 2879
Score = 77.0 bits (188), Expect = 7e-14
Identities = 140/724 (19%), Positives = 301/724 (41%), Gaps = 104/724 (14%)
Query: 44 EALEQLFVVEQSLQSDYFKCNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKLY 103
E L + +Q S+ K K L++ A +++E K +++L+ + ELN+
Sbjct: 2213 ENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAV 2272
Query: 104 YLL---ETLPNSIKRELEECVRDARRLNLFEINTIKMRITRTENE----IELLKKKI--T 154
L + + + ++ L+ + + +L I ++ R+ E + ++ LK+
Sbjct: 2273 AALCGDQEIMKATEQSLDPPIEEEHQLRN-SIEKLRARLEADEKKQLCVLQQLKESEHHA 2331
Query: 155 DLTKYNEALGEKQEELARKHARFVLSLNQTMEKKATTTVYINETYTKINLKREDIALQKK 214
DL K E++ E+AR + + + + T E T+ + L
Sbjct: 2332 DLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQ---SLRGLELDVV 2388
Query: 215 CIQEAEELMEKERAEYLIRKQELTAQINEFENTREVKRMETYQKKKE----LDKLQTKMS 270
I+ +E + E + R EL + FEN + K E Q K++ ++ LQT++
Sbjct: 2389 TIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLK 2448
Query: 271 KIKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDD 330
++ E V AA+ +D E+ + EQ +S + L + +A+L D
Sbjct: 2449 ELNERV---AALHNDQ--------EACKAKEQNLSSQVECLELEKAQLLQGLD------- 2490
Query: 331 ISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHD 390
+ KN ++ L +++ E +D ++K++ ++E+ K +I D
Sbjct: 2491 ---EAKNNYI----VLQSSVNGLIQEVEDGKQKLE----------KKDEEISRLKNQIQD 2533
Query: 391 ENQ--KQLTFISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSANLERE 448
+ Q +L+ + + ++ ++++N+ L ++ Q+ Q +++L ++ +
Sbjct: 2534 QEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNL 2593
Query: 449 SQRCVITQWKMACLRKKHARWTAK---IKAEIQAITEKIQNAEVR----RIELLNETSFR 501
+T+ +K + TAK ++ E+ + +K + + L E
Sbjct: 2594 ENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLL 2653
Query: 502 QQEISGFVAQIEKLTTELKEEEKAF-------VNKEKMLMKELSKYEEIFVKETQINKEK 554
+EI Q+++LT E E +K+ V KE + +E+++Y+ ++ + K+
Sbjct: 2654 LEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQ---LRLHEAEKKH 2710
Query: 555 EEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLL-------NNHIFLFTR-- 605
+ L++ Q +V Q Y+EK EE +++Q+ E DLL NN + T+
Sbjct: 2711 QALLLDTNKQYEVEIQTYREKLTSKEEC---LSSQKLEIDLLKSSKEELNNSLKATTQIL 2767
Query: 606 --------DFSRYISNMEDVKQELQ-----------QLRDQES--KKNKDHFETLKNLEN 644
D +Y++ ++ + Q QL +++ +K + + +
Sbjct: 2768 EELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQK 2827
Query: 645 GFYINDQKADLLLLENKKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKD 704
+ D K D L E K+LKE + ++Y + +L+ + L + E Q
Sbjct: 2828 TGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAH 2887
Query: 705 LWAE 708
L ++
Sbjct: 2888 LCSQ 2891
Score = 75.9 bits (185), Expect = 1e-13
Identities = 145/771 (18%), Positives = 310/771 (40%), Gaps = 115/771 (14%)
Query: 44 EALEQLFVVEQSLQSDYFKCNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKLY 103
+A +F +Q + N + +D + + E+ + L+I + N +
Sbjct: 211 QASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSF 270
Query: 104 YLLETLPNSIKRELEECVRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEAL 163
+ + P+ + +L+ ++ R +IN +++R+ E E +K ++ + L
Sbjct: 271 FDNSSSPHLLD-QLKAQNQELRN----KINELELRLQGHEKE---MKGQVNKFQELQLQL 322
Query: 164 GEKQEELARKHARFVLSLNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELM 223
+ + EL K LN+ ++ TT ++ TK AL++K + E+L
Sbjct: 323 EKAKVELIEKEK----VLNKCRDELVRTTAQYDQASTKYT------ALEQKLKKLTEDL- 371
Query: 224 EKERAEYLIRKQELTAQINEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVL 283
+ Q E+ R + +K+KE + ++ + +T+ +
Sbjct: 372 --------------SCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQM 417
Query: 284 SDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKI 343
ARL QE+ + K +L+A+L T K++L++ EF K+
Sbjct: 418 K------ARL-------TQELQQAKNMHNVLQAELDKLTSVKQQLEN----NLEEFKQKL 460
Query: 344 KQLVETLHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKE 403
+ + A++++ +LR M+ + ++ ++ S E+ + + E + ++Q +
Sbjct: 461 CRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQ 520
Query: 404 YFLSQKRVDIKNMEEGLITLQE-LQQATKTVYQQQIKILSANLERESQRCVITQWKMACL 462
F + + + E L LQE + Q ++ +++K+ A+LE++ L
Sbjct: 521 NFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQ------RDCSQDLL 574
Query: 463 RKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEE 522
+K+ + I+ + +K+ E LL+ +++E ELKEE
Sbjct: 575 KKR--------EHHIEQLNDKLSKTEKESKALLSALELKKKEYE-----------ELKEE 615
Query: 523 EKAF----VNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRK 578
+ F EK+L + S+ E + + K L L Q+ EY E+ R
Sbjct: 616 KTLFSCWKSENEKLLTQMESEKENL--------QSKINHLETCLKTQQIKSHEYNERVRT 667
Query: 579 LEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFET 638
LE + + ++ N H L ++ S + + ELQQ + +K++ E
Sbjct: 668 LE-----MDRENLSVEIRNLHNVLDSK--SVEVETQKLAYMELQQKAEFSDQKHQKEIEN 720
Query: 639 --LKNLENGFYINDQKADLLLLENKKLKEYILY--LKNNIEKYRE---GQEALMHTSNDL 691
LK + + D + L LL N+ + + Y L E R+ ++A + T+ D
Sbjct: 721 MCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDH 780
Query: 692 SRQLIAQEAQ------YKDLWAE------FQTTVKILVDNGEETLQDINNLTDKLRERDE 739
R L+A + Q + ++ E ++ ++ D + + N D L E
Sbjct: 781 QRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLE 840
Query: 740 KMQHVSTWLRGSLEGLRLLVEQESPMDLLSKQQLRALLVTSKEEKTCQLSD 790
+ +++ L+ E L + ++ E +L+ +Q+ V ++ +L +
Sbjct: 841 SQKQMNSDLQKQCEEL-VQIKGEIEENLMKAEQMHQSFVAETSQRISKLQE 890
Score = 71.2 bits (173), Expect = 4e-12
Identities = 93/544 (17%), Positives = 238/544 (43%), Gaps = 38/544 (6%)
Query: 112 SIKRELEECVRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELA 171
++K ++E + R L L ++ TI+ NE++ +++I++L N + +E
Sbjct: 2368 TLKAKIEGMTQSLRGLEL-DVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKE 2426
Query: 172 RKHARFVLSLNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKERAEYL 231
++ + + ME T +NE ++ +E +++ + E +E E+A+ L
Sbjct: 2427 QEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLL 2486
Query: 232 IRKQELTAQINEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIA 291
E +++ E K++L+K ++S++K + ++S +++
Sbjct: 2487 QGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVS----KLS 2542
Query: 292 RLHESIRYWEQE-------VSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEF-LNKI 343
++ + W+++ EL++ + +L++K D E L + +NE L K+
Sbjct: 2543 QVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKM 2602
Query: 344 KQL--VETLHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQ 401
++ VE ++ + +L+ +M +A++ +E+ +K ++ E Q L I
Sbjct: 2603 DKMSFVEKVNKMTAKETELQREMHEMAQK---TAELQEELSGEKNRLAGELQLLLEEIKS 2659
Query: 402 KEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSANLERESQRCVITQWKMAC 461
+ L + ++ +++ L + + Q + +++I L ++ A
Sbjct: 2660 SKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKK------HQAL 2713
Query: 462 LRKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKE 521
L + ++ +I+ + +T K + +++E+ + ++E++ + ++ ELK+
Sbjct: 2714 LLDTNKQYEVEIQTYREKLTSKEECLSSQKLEI-DLLKSSKEELNNSLKATTQILEELKK 2772
Query: 522 EEKAFVNKEKMLMKELSKYE---EIFVKETQINKEKEEELVEYLPQLQVAEQEYK----- 573
+ + L KE + + ++ +K + +E++E L + L QLQ A+++ K
Sbjct: 2773 TKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVM 2832
Query: 574 -----EKRRKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQQLRDQE 628
E +++EL + + +E D + + E ++ ++ L Q+
Sbjct: 2833 DTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHLCSQQ 2892
Query: 629 SKKN 632
SK++
Sbjct: 2893 SKQD 2896
Score = 66.6 bits (161), Expect = 9e-11
Identities = 160/807 (19%), Positives = 315/807 (39%), Gaps = 129/807 (15%)
Query: 96 SMELNKLYYLLETLPNSIKRELEECVRDARRLNLFEINTIKMRITRTENEIELLKKKITD 155
S E +L +++E ++ L E +L+L E+ + T+ E IEL +K + +
Sbjct: 1780 SNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLM----TKIEACIEL-EKIVGE 1834
Query: 156 LTKYNEALGEKQEELARKHARFVL------SLNQTMEKKA--TTTVYINETYTKIN---- 203
L K N L EK E + H + LN +E A ++ I + K+N
Sbjct: 1835 LKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWK 1894
Query: 204 ------------LKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQ--INEFENTRE 249
++ E +++ + + +L + + + K Q I E
Sbjct: 1895 ERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELS 1954
Query: 250 VKRMETYQKKKELD---KLQTKMSKIKETVTVSAAVLSDHN-----------LEIARLHE 295
V E Q + ELD K T + ++ E + L H E+ E
Sbjct: 1955 VVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTE 2014
Query: 296 SIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEF--LNKIKQLV----ET 349
++ +VSEL KD L+ KL + + L + +N+ LNK K+L+ E+
Sbjct: 2015 LLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESES 2074
Query: 350 LHA--ARMEYKDLREKMKTLAR-----QYKIVLSEEEKAFLQ--------KQKIHDENQK 394
L A + +Y+ L A ++ + LS ++ Q + +I + +K
Sbjct: 2075 LQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKK 2134
Query: 395 QLTFISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSANLERESQRCVI 454
QL I++K ++ +K+ E L +ELQ + + Q++ IL A + +
Sbjct: 2135 QL-HIAEKLKERERENDSLKDKVENLE--RELQMSEEN---QELVILDAENSKAEVETLK 2188
Query: 455 TQWK-MACLRKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIE 513
TQ + MA K +++E + +T++IQ + + L+E + + E
Sbjct: 2189 TQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQ----LSELDKLLSSFKSLLEEKE 2244
Query: 514 KLTTELKEEEKAFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYK 573
+ ++KEE K V + +KEL++ + +I K E+ L + + +
Sbjct: 2245 QAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIE 2304
Query: 574 EKRRKLE--ELSNIITAQRQEE-----DLLNNHIFLFTRDFSRYISNM-------EDVKQ 619
+ R +LE E + Q+ +E DLL + R+ +N E+ K
Sbjct: 2305 KLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKG 2364
Query: 620 ELQQLR---------------------------DQESKKNKDHFETLKNLENGF--YIND 650
E++ L+ E +K ++ L+ + + F + +
Sbjct: 2365 EVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQE 2424
Query: 651 QKADLLLLENKK------LKEYILYLKNNIEKYREGQEALMHTSNDLSRQ---LIAQEAQ 701
++ + + ++ K L+ + L + QEA +LS Q L ++AQ
Sbjct: 2425 KEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQ 2484
Query: 702 YKDLWAEFQTTVKILVDNGEETLQDINNLTDKLRERDEKMQHVSTWLRGSLEGLRLLVEQ 761
E + +L + +Q++ + KL ++DE++ + ++ + + L +
Sbjct: 2485 LLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQV 2544
Query: 762 ESPMDLLSKQQLRALLVTSKEEKTCQL 788
E L +Q L +T + E+ Q+
Sbjct: 2545 EGEHQLWKEQNLELRNLTVELEQKIQV 2571
Score = 66.2 bits (160), Expect = 1e-10
Identities = 106/527 (20%), Positives = 215/527 (40%), Gaps = 48/527 (9%)
Query: 223 MEKERAEYLIRKQELTAQINEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAV 282
++K+ E + K E+ + + E + ET Q+ + KLQ S + V + +
Sbjct: 849 LQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQR---ISKLQEDTSAHQNVVAETLSA 905
Query: 283 LSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNK 342
L + E+ L++ + + E+ ELKK +LE L + L + + EK
Sbjct: 906 LENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSL----KELQLLSETLSLEK------ 955
Query: 343 IKQLVETLHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQK 402
K++ + + E ++L ++ TL ++ L++E+ +QK ++ +I ++
Sbjct: 956 -KEMSSIISLNKREIEELTQENGTL-KEINASLNQEKMNLIQK------SESFANYIDER 1007
Query: 403 EYFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSANLERESQRCVITQWKMACL 462
E +S+ K +E LI LQ ++ K +A + C++ + C
Sbjct: 1008 EKSISELSDQYK--QEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCE 1065
Query: 463 RKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEE 522
+K+ E++ + E E L + +F ++ + ++E + L+ E
Sbjct: 1066 NRKN---------ELEQLKEAFAK---EHQEFLTKLAFAEERNQNLMLELETVQQALRSE 1113
Query: 523 EKAFVNKEKMLMKELSKYEEIFVKETQ--INKEKEEELVEYLPQLQVAEQEYKEKRRKLE 580
N K L K E + +KE Q + KE + L E ++V + +++ + + E
Sbjct: 1114 MTDNQNNSKSEAGGL-KQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESE 1172
Query: 581 ELSNIITAQRQEEDLLN--NHIFLFTRDFSRYISNMEDVKQEL----QQLRDQESKKNKD 634
+ N + + E + N + L ++ S N + V+ E ++L+ QES+K K+
Sbjct: 1173 PIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKE 1232
Query: 635 HFETLKNLENGFYINDQKADLLLLENKKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQ 694
+ G D+ E LK+ + + EKY G L + ND +
Sbjct: 1233 CLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAE---EKYISGPHELSTSQNDNAHL 1289
Query: 695 LIAQEAQYKDLWAEFQTTVKILVDNGEETLQDINNLTDKLRERDEKM 741
+ + L E + +IL E + ++N+ + KM
Sbjct: 1290 QCSLQTTMNKL-NELEKICEILQAEKYELVTELNDSRSECITATRKM 1335
Score = 57.0 bits (136), Expect = 7e-08
Identities = 134/718 (18%), Positives = 297/718 (41%), Gaps = 62/718 (8%)
Query: 99 LNKLYYLLETLPNSIKRELEECVRDARRLNLFEINTIKMRITRTENEIELLKKK-ITDLT 157
+ +L L E S+++ LEE + + EI ++ ++ E++ L+K+ +++
Sbjct: 1549 VEELESLCEVYRQSLEK-LEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENE 1607
Query: 158 KYNEALGEKQEELARKHARFVLSLNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQ 217
++ + L E+ K A EKK T + + ++ L+ D++ +
Sbjct: 1608 QWQQKLTSVTLEMESKLAA---------EKKQTEQLSLELEVARLQLQGLDLSSRSLLGI 1658
Query: 218 EAEELMEKERAEYLIRKQELTAQINEFENTREVKRMETYQKKKELD---KLQTKMSKIKE 274
+ E+ ++ I K+ T++ E +V ++ +++L+ + T+ +K
Sbjct: 1659 DTEDAIQGRNESCDISKEH-TSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKP 1717
Query: 275 TVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISND 334
T S D N E ++ Q SE +L+ D +DI N
Sbjct: 1718 TGECSGEQSPDTNYEPPGEDKT-----QGSSECISELSFSGPNALVPMDFLGNQEDIHNL 1772
Query: 335 EKN--EFLNKIKQLVETLHAARMEYKDLREKMKTLARQY---KIVLSEEEKAFLQKQKIH 389
+ E N+ +L+ + + + L +MK L + ++ L + +A ++ +KI
Sbjct: 1773 QLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIV 1832
Query: 390 DENQKQLTFISQK-EYFLSQKRVDIKNME--EGLITLQELQQATKTVYQQQIKILSANLE 446
E +K+ + +S+K EYF + ++ +E EGL + E+ + + N +
Sbjct: 1833 GELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVN-D 1891
Query: 447 RESQRCVITQWKMACLRKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEIS 506
+R + + +++ +R + A I+ E + ++ + ++ L + +Q+ I
Sbjct: 1892 SWKERFLDVENELSRIRSEKA----SIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIV 1947
Query: 507 GFVAQIEKLTTELKEEEKAFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQ 566
++ +T+E + + + K+ + +++ K + +E E E L +Q
Sbjct: 1948 CLEEELSVVTSERNQLR----GELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQ 2003
Query: 567 VAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQQLRD 626
VAE E KEK L+ LS+ ++ +++ L + +D +++ ++ QL
Sbjct: 2004 VAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNK 2063
Query: 627 QESKKNKDHFETLKNLENGFY--INDQKA-DLLLLEN-------KKLKEYILYLKNNIEK 676
++ K+ L Y +N KA + L+E +E + L+ IEK
Sbjct: 2064 EKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEK 2123
Query: 677 YREGQEALMHTSNDLSRQLIAQEAQ---YKDLWAEFQTTVKILVDNGEETLQDINNLTDK 733
R EA ++ +L +E + KD + +++ +N E + D N
Sbjct: 2124 LRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAEN---- 2179
Query: 734 LRERDEKMQHVSTWLRGSLEGLRLLVEQESPMDLLSKQQLRALLVTSKEEKTCQLSDL 791
+++ + T + L++ +DL++ + + L +EK QLS+L
Sbjct: 2180 ---SKAEVETLKTQIEEMARSLKVF-----ELDLVTLRSEKENLTKQIQEKQGQLSEL 2229
Score = 38.1 bits (87), Expect = 0.034
Identities = 107/605 (17%), Positives = 233/605 (38%), Gaps = 117/605 (19%)
Query: 128 NLFEINTIKMRITRTEN-EIELLKKKITDLTKYNE-ALGEKQEELARKHARFVLSLN--- 182
N +E + K + + +N ++E L + T L + + L + +E A++H F+ L
Sbjct: 1034 NAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAE 1093
Query: 183 ----------QTMEKKATTTVYINETYTK----------INLKREDIALQKKC---IQEA 219
+T+++ + + N+ +K + LK E +QK+ +QE
Sbjct: 1094 ERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQEN 1153
Query: 220 EELMEKERAEYLIRKQELTAQINEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVS 279
E+LM+ + ++ + E N + + ++ + +L+ + + +
Sbjct: 1154 EQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQL 1213
Query: 280 AAVLSDHNLEIARLHESIRYWEQEVSELKKDL-----------AILEAKLC------FFT 322
A+L + L++ + + E+ ++ DL I K C +
Sbjct: 1214 EAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYI 1273
Query: 323 DNKEKLDDISNDEKN---------EFLNKIKQLVETLHAAR----MEYKDLREKMKTLAR 369
+L ND + LN+++++ E L A + E D R + T R
Sbjct: 1274 SGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATR 1333
Query: 370 QY---------KIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGL 420
+ ++ + ++ L + + D + +++ +S +D N E L
Sbjct: 1334 KMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHL 1393
Query: 421 -ITLQELQQATKTVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQA 479
++ +E+Q + ++ + + S + Q C ++ KM+ L+ + +KAE
Sbjct: 1394 TLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSS-KMSELQ----TYVDSLKAENLV 1448
Query: 480 ITEKIQNAE---VRRIELLNETSFRQQEISGFVAQIEKLTT-----------ELKEEEKA 525
++ ++N + V+ ++L E S V L++ E +
Sbjct: 1449 LSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSL 1508
Query: 526 FVNKEKMLMKELSKYEEIFV----------KETQINKEKEEELVE-----YLPQLQVAEQ 570
N E + +E+F KET K E +E Y L+ E+
Sbjct: 1509 LSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEE 1568
Query: 571 EYKE----KRRKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQQLR- 625
+ + K ++++EL +++++RQE D L +Y+S E +Q+L +
Sbjct: 1569 KMESQGIMKNKEIQELEQLLSSERQELDCLR----------KQYLSENEQWQQKLTSVTL 1618
Query: 626 DQESK 630
+ ESK
Sbjct: 1619 EMESK 1623
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 98.6 bits (244), Expect = 2e-20
Identities = 179/803 (22%), Positives = 342/803 (42%), Gaps = 100/803 (12%)
Query: 29 ELCTLPSTLGSSVAVEALEQ---LFVVEQ--------SLQSDYFKCNEEAKIFLKDIAVA 77
EL + P T G+ ++AL + ++E+ SL+ + K +E + + + A
Sbjct: 57 ELRSKPVTEGTGDIIKALTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDA 116
Query: 78 VKKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEECVRDARRLN--LFEINTI 135
K+LE+ + +E EL + +++++LEE + L+ L N
Sbjct: 117 HKELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNS 176
Query: 136 KMRITRTENEIELLK----KKITDLTKYNEALGEKQEELARKHARFVLSLNQTMEKKATT 191
+ + + + EIE ++ ++I L K +A ++++E + + + +Q +K
Sbjct: 177 EDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKN--- 233
Query: 192 TVYINETYTKINLKREDIALQKKCI--QEAEELMEKERAEYLIRKQELTAQINEFENTRE 249
IN +E++ LQ K I +E +ELM + A +E A+IN+ +E
Sbjct: 234 ----------INSLQEEL-LQLKAIHQEEVKELMCQIEAS----AKEHEAEINKLNELKE 278
Query: 250 --VKRMETYQK---KK---ELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWE 301
VK+ E +K KK EL+ L+ S + + + +L ++ ++E +++ E
Sbjct: 279 NLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLE 338
Query: 302 QEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQL---VETLHAARMEYK 358
+ EL+ +IL+ ++ + + K KL+ + K+EF ++ + L + L A+ E
Sbjct: 339 DTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQG 398
Query: 359 DLREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEE 418
+ EK+K+ E A L KQ + Q S KE Q + +I + E
Sbjct: 399 CVIEKLKS------------ELAGLNKQFCYTVEQHNREVQSLKE----QHQKEISELNE 442
Query: 419 GLITLQELQQATKTVYQQQIKILSANLERESQRCVITQWK----MACLRKKHARWTAKIK 474
++ E ++ T Q +K NL++E Q ++ M L+ + KI
Sbjct: 443 TFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKIS 502
Query: 475 AEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLM 534
E +++ ++ Q ++V ++ T+F +++ A +E + E EK +E L+
Sbjct: 503 QEFESMKQQ-QASDVHELQQKLRTAFTEKD-----ALLETVNRLQGENEKLLSQQE--LV 554
Query: 535 KELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKL----EELSNIITAQR 590
EL E I +E+ V YL L + KE K+ EE + I +
Sbjct: 555 PEL---------ENTIKNLQEKNGV-YLLSLSQRDTMLKELEGKINSLTEEKDDFINKLK 604
Query: 591 QEEDLLNNHIFLFTRDFSRYISNMEDVKQELQQLRDQESKKNK---DHFETLKNLENGFY 647
+ ++N R+ + + V+Q +Q + E K N+ ETLK +
Sbjct: 605 NSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQ--- 661
Query: 648 INDQKADLLLLENKKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWA 707
NDQK + L+++ K L E L ++ E L LSR L +Q +D+
Sbjct: 662 -NDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVIL 720
Query: 708 EFQTTVKILVDNGEETLQDINNLTDKLRERDEKMQHVSTWLRGSLEGLRLLVEQES-PMD 766
+ T L + +++ +NL L + V T L G L+ + V ++S D
Sbjct: 721 KEHITQ--LEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKD 778
Query: 767 LLSKQQLRALLVTSKEEKTCQLS 789
+++ Q + E+ C L+
Sbjct: 779 VVNVLQAVGESLAKINEEKCNLA 801
Score = 93.2 bits (230), Expect = 9e-19
Identities = 145/691 (20%), Positives = 305/691 (44%), Gaps = 76/691 (10%)
Query: 78 VKKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEECVRDARR-LNLFEINTIK 136
++KL K + E+ S E+ LY N + E ++ RD L+ E +K
Sbjct: 666 LEKLMVQMKVLSEDKEVLSAEVKSLY----EENNKLSSEKKQLSRDLEVFLSQKEDVILK 721
Query: 137 MRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFVL------SLNQTMEKKAT 190
IT+ E +++L+ ++ +L K E E+ ++L K + +++ E+K
Sbjct: 722 EHITQLEKKLQLMVEEQDNLNKLLE--NEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDV 779
Query: 191 TTVY--INETYTKINLKREDIALQK-KCIQEAEELMEKERAEYLIRKQELTAQINEFENT 247
V + E+ KIN ++ ++A Q+ + + E E+ ++ + E +++ +EL + + ++E
Sbjct: 780 VNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQE 839
Query: 248 REVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEI-----------ARLH-E 295
+ + R E + + E + LQ+ + ++K + L + NL I + +H E
Sbjct: 840 KVLLRKELEEIQSEKEALQSDLLEMKNANEKTR--LENQNLLIQVEEVSQTCSKSEIHNE 897
Query: 296 SIRYWEQEVSELK-----KDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETL 350
+ + +E LK K+L A+L D+ K + ND L+ +K+L E +
Sbjct: 898 KEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDP----LSSVKELEEKI 953
Query: 351 HAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFI-SQKEYFLSQK 409
E K+ EK+ + K+V + +K +K +++L + S+K+ +
Sbjct: 954 ENLEKECKEKEEKINKI----KLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASM 1009
Query: 410 RVDIKNMEEGLITLQELQQATKTV---------YQQQIKILSANLERESQRC--VITQWK 458
R I+ E L E ++ ++ + ++ +I+ L+ L + +C + + +
Sbjct: 1010 RDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNE 1069
Query: 459 MACLRKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTE 518
R + + AK+ E+Q + + A V + EL E ++Q+I + +L
Sbjct: 1070 DLLARIETLQSNAKL-LEVQILEVQRAKAMVDK-ELEAEKLQKEQKIKEHATTVNEL--- 1124
Query: 519 LKEEEKAFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRK 578
EE + + KEK +++ + E+ K+ Q E+ +Y ++ Q+ K K
Sbjct: 1125 --EELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNK 1182
Query: 579 LEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQQLRDQ--ESKK-NKDH 635
+E+L I Q+Q+++ L I +Y +KQ L + + + +SK+ DH
Sbjct: 1183 IEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDH 1242
Query: 636 FETLKNLENGFYINDQKADL-------LLLENKKLKEYILYLKNNIEKYREGQEALMHTS 688
+L+ + Q+ ++ + E K+ E +LK + E+++ A
Sbjct: 1243 LILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHE---HLKTSAEQHQRTLSAYQQRV 1299
Query: 689 NDLSRQLIAQEAQYKDLWAEFQTTVKILVDN 719
L + A +A+ + +EF+ + K+ V N
Sbjct: 1300 TALQEECRAAKAEQATVTSEFE-SYKVRVHN 1329
Score = 35.4 bits (80), Expect = 0.22
Identities = 89/517 (17%), Positives = 218/517 (42%), Gaps = 82/517 (15%)
Query: 79 KKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEECVRDARRLNLFEINTIKMR 138
K+ +E + I L+ + + ++ L K+EL + + A +L ++K
Sbjct: 1194 KQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADS-KQAETDHLILQASLKGE 1252
Query: 139 ITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFVLSLNQTMEKKATTTVYINET 198
+ ++ ++E+ K ++ ++T + E + A +H R + + Q +
Sbjct: 1253 LEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVT------------ 1300
Query: 199 YTKINLKREDIALQKKC--IQEAEELMEKERAEYLIRKQELTAQINEFENTREVKRMETY 256
ALQ++C + + + E Y +R + Q + + + + ET
Sbjct: 1301 -----------ALQEECRAAKAEQATVTSEFESYKVRVHNVLKQ----QKNKSMSQAETE 1345
Query: 257 QKKKE-------LDKLQTKMSKIKETVTVSAAVL----SDHNLEIARLHESIRYWEQEVS 305
K+E +D+L+ K+ + + ++ + L S+H+ + R ++ ++ + +
Sbjct: 1346 GAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEA 1405
Query: 306 ELKKDLAILEAK-LCFFTDNKEKLDDISNDE---KNEFLNKIKQLVETLHAARMEYKDLR 361
EL++ L ++++ + +++ + + +++ +N F ++++ L E + R
Sbjct: 1406 ELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQE----------EHR 1455
Query: 362 EKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLI 421
+ ++TL +Q LS+ E A L + K + ++ + ++ D+ ++ +
Sbjct: 1456 KTVETLQQQ----LSKME-AQLFQLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTV 1510
Query: 422 TLQELQQATKTVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKAE--IQA 479
T +E + +T + + S + Q + K+ + W A+ E +Q
Sbjct: 1511 TREE-GEGMETTDTESVSSASTYTQSLEQLLNSPETKL-----EPPLWHAEFTKEELVQK 1564
Query: 480 ITEKIQNAE-----VRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLM 534
++ ++A+ +R E N + ++I ++I +L +E EK+ N E L
Sbjct: 1565 LSSTTKSADHLNGLLRETEATN--AILMEQIKLLKSEIRRLERN-QEREKSAANLE-YLK 1620
Query: 535 KELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQE 571
L ++ IF+K E+E L LQ++ +E
Sbjct: 1621 NVLLQF--IFLKP---GSERERLLPVINTMLQLSPEE 1652
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 97.8 bits (242), Expect = 4e-20
Identities = 158/757 (20%), Positives = 323/757 (42%), Gaps = 105/757 (13%)
Query: 72 KDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKREL---EECVRDARRLN 128
+D+ + KL+E I +L E L + + ET + EL + +D+ L
Sbjct: 1269 QDLEKSHTKLQE----EIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLA 1324
Query: 129 LFEINTIKM--RITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFVLSLNQTME 186
E+ +++ + ++ EI+ L K+ +L EAL K ++L ++H R L+ Q +
Sbjct: 1325 RIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQL-KEHIRETLAKIQESQ 1383
Query: 187 KKATTTVYI----NETYTKINLKREDIALQKKCIQEAEELM---EKERAEYLIRKQELTA 239
K ++ + NET TKI + E + + E M K E + +
Sbjct: 1384 SKQEQSLNMKEKDNET-TKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAK 1442
Query: 240 QINEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRY 299
+ ++ + +EV + E+ Q K+ + ++ K + +E + V+ L + I L ++
Sbjct: 1443 EKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSE 1502
Query: 300 WEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKD 359
E E+S ++K L + KL + K+ +I E+ + +I ++ E ++ + ++K+
Sbjct: 1503 KETEISTIQKQLEAINDKL------QNKIQEIYEKEEQFNIKQISEVQEKVNELK-QFKE 1555
Query: 360 LREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEG 419
R K K A Q S E K ++ + ++ I +KE ++K ++E
Sbjct: 1556 HR-KAKDSALQ-----SIESKMLELTNRLQESQEEIQIMIKEKE--------EMKRVQEA 1601
Query: 420 L-ITLQELQQATKTVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTA----KIK 474
L I +L++ TK + + +ESQ KM + + + K +
Sbjct: 1602 LQIERDQLKENTKEIVAKM---------KESQEKEYQFLKMTAVNETQEKMCEIEHLKEQ 1652
Query: 475 AEIQAIT-EKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELK-EEEKAFVNKEKM 532
E Q + E I+ +R ++L+E + ++ + + LK E ++ N +
Sbjct: 1653 FETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRET 1712
Query: 533 LMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQ--R 590
+ ++L K EE+ + + KE +E + + + E ++ LE ++ + AQ +
Sbjct: 1713 ITRDLEKQEELKIVHMHL-KEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLK 1771
Query: 591 QEEDLLNNHIFLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNLENGFYIND 650
+E+L H+ L ++ ++ + +LR S+K K+LEN
Sbjct: 1772 IQEELRIAHMHL------------KEQQETIDKLRGIVSEKTDKLSNMQKDLENS----- 1814
Query: 651 QKADLLLLENKKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQ 710
N KL+E I LK N + L N+ +++ E K + +
Sbjct: 1815 ---------NAKLQEKIQELKANEHQLI----TLKKDVNETQKKVSEMEQLKKQIKDQSL 1861
Query: 711 TTVKILVDN---GEETLQDINNLTDKLRERDEKMQHVSTWLRGSLEGLRLLVEQESPMDL 767
T K+ ++N ++ +++ + ++ERD ++ V L+ + L+ +++ DL
Sbjct: 1862 TLSKLEIENLNLAQKLHENLEEMKSVMKERDN-LRRVEETLKLERDQLKESLQETKARDL 1920
Query: 768 LSKQQLRALLVTSKE-------------EKTCQLSDL 791
+Q+L+ + SKE EKT Q+SD+
Sbjct: 1921 EIQQELKTARMLSKEHKETVDKLREKISEKTIQISDI 1957
Score = 89.0 bits (219), Expect = 2e-17
Identities = 166/792 (20%), Positives = 333/792 (42%), Gaps = 110/792 (13%)
Query: 78 VKKLEEMRKATIDLLEIESMELNKLYYLLETL--PNSIKREL---EECVRDARRLNLF-- 130
+KKL+E ID ++E+++++ L Y LE++ P +K+ L E DA+R + F
Sbjct: 591 IKKLQEY----IDSQKLENIKMD-LSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLR 645
Query: 131 --------EINTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFVLSLN 182
++ + + EN+I+L + ++ K L ++ + + + ++
Sbjct: 646 SENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLID 705
Query: 183 QTMEKKATTTVYINETYTKINLK-----REDIALQKKCIQEAEELMEKERAEYLIRK-QE 236
+ K + + T + + E+ AL+++ I +E E L ++ Q+
Sbjct: 706 GKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQD 765
Query: 237 LTAQINEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIA----- 291
+ +++ + ++ E K+ + L ++ K K+ + + + + E
Sbjct: 766 KSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTL 825
Query: 292 ----------------RLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDE 335
R+++ I +E + L L+ +L + T ++ E
Sbjct: 826 HMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQE----KTRE 881
Query: 336 KNEFLNKIKQLVE-------TLHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKI 388
E LN+++QL E TL E + EK++ + K L++E+ Q Q+
Sbjct: 882 VQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVK-TLTQEKDDLKQLQES 940
Query: 389 HDENQKQLTFISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKI---LSANL 445
+ QL K ++I E+ L+ L+Q +T+ + KI +S NL
Sbjct: 941 LQIERDQL-----KSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNL 995
Query: 446 ERESQRCVIT---QWKMACLRKKH---ARWTAKIKAEIQAITEKIQNAEVRRIELLNETS 499
E Q KM + KK A+ T + A+++ +I + + L+ E +
Sbjct: 996 HMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVK--DNEIIEQQRKIFSLIQEKN 1053
Query: 500 FRQQEISGFVAQIEKLTTELKEE-EKAFVNKE--KMLMKELSKYEEIFVKETQINKEKEE 556
QQ + +A+ E+L T+LKE E N+E ++L EL K +EI +E +KE
Sbjct: 1054 ELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEG 1113
Query: 557 ELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMED 616
EL +L E++ KEK ++L+E + ++E + I + + N E
Sbjct: 1114 ELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEI-ENLKNELKNKEL 1172
Query: 617 VKQELQQLRDQESKKNKDHFETLKNLENGFYINDQKADLLLLENKKLKEYILYLK-NNIE 675
+ ++ R + ++K +++E +K++ + + E L+ YI ++ ++
Sbjct: 1173 TLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQ 1232
Query: 676 KYREGQEALMH------TSNDLSRQLIAQEAQY---KDL---WAEFQTTVKIL------- 716
E + A +H T ++L R + + AQ +DL + Q + +L
Sbjct: 1233 TKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELL 1292
Query: 717 -----VDNGEETLQDINNLTDKLRERDEKMQHVSTWLRGSLEGLRLLVE-QESPMDLLSK 770
V +ET+ ++ LT++ +D +T R +E LRL + QES ++ S
Sbjct: 1293 PNVKEVSETQETMNELELLTEQSTTKDS-----TTLARIEMERLRLNEKFQESQEEIKSL 1347
Query: 771 QQLRALLVTSKE 782
+ R L T KE
Sbjct: 1348 TKERDNLKTIKE 1359
Score = 79.0 bits (193), Expect = 2e-14
Identities = 168/810 (20%), Positives = 355/810 (43%), Gaps = 118/810 (14%)
Query: 47 EQLFVVEQSLQSDYF---KCNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIE-SMELNKL 102
E L + L+SD N + + L++ ++K+ +E TI+ L+ + S E+++
Sbjct: 939 ESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQE----TINTLKSKISEEVSRN 994
Query: 103 YYLLETLPNSIKRELEECVRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEA 162
++ E + ++ V ++ +L NT + +NEI ++KI L +
Sbjct: 995 LHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNE 1054
Query: 163 LGEKQEELARKHARFVLSLNQTMEKKATTTVYINETYTKINLKREDIA------------ 210
L + E + + + L + +E + ++ ++E +A
Sbjct: 1055 LQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGE 1114
Query: 211 LQKKC--IQEAEELMEKERAEYLIRKQ-----------ELTAQINEFENTREVKRMETYQ 257
L + C + E EE + KE+++ L KQ E+ +INE EN + E
Sbjct: 1115 LSRTCDRLAEVEEKL-KEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKN----ELKN 1169
Query: 258 KKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAK 317
K+ L+ ++T+ ++ + + + + E L E + +E E L+ + +EA
Sbjct: 1170 KELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEA- 1228
Query: 318 LCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLSE 377
T + K+ I E E ++++++ V A + +DL EK T ++ VL E
Sbjct: 1229 TGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDL-EKSHTKLQEEIPVLHE 1287
Query: 378 EEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQ 437
E++ +++ + + E ++ + +E + L E Q + Q++
Sbjct: 1288 EQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQES----QEE 1343
Query: 438 IKILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNE 497
IK L+ ER++ + + L KH ++K I+ KIQ ++ ++ + LN
Sbjct: 1344 IKSLTK--ERDNLKTI-----KEALEVKH----DQLKEHIRETLAKIQESQSKQEQSLNM 1392
Query: 498 TSFRQQEISGFVAQIEK-----------------LTTELKE--EEKAFVNKEKMLMKELS 538
+ E + V+++E+ L+ L+E +E V KEK +L
Sbjct: 1393 KE-KDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEK---DDLQ 1448
Query: 539 KYEEIFVKETQINKEKEEELV----EYLPQLQVAEQEYKEKRRKLEEL--------SNII 586
+ +E+ E+ KE +E+V E +L+VA KE+ + EL + I
Sbjct: 1449 RLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEIS 1508
Query: 587 TAQRQEE---DLLNNHI-FLFTRDFSRYISNMEDVKQELQQLRD-QESKKNKDHFETLKN 641
T Q+Q E D L N I ++ ++ I + +V++++ +L+ +E +K KD L++
Sbjct: 1509 TIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKD--SALQS 1566
Query: 642 LENGFYINDQKADLLLLENK--KLKEYILYLKNNIEKYREGQEALMHTSNDL---SRQLI 696
+E + +L L N+ + +E I + E+ + QEAL + L +++++
Sbjct: 1567 IE---------SKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIV 1617
Query: 697 AQEAQYKDLWAEFQTTVKILVDNGEETLQDINNLTDKLRERDEKMQHVSTWLRGSLEGLR 756
A+ + ++ E+Q V+ +E + +I +L ++ + ++++ T ++ +
Sbjct: 1618 AKMKESQE--KEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIET---ENIRLTQ 1672
Query: 757 LLVEQESPMDLLSKQQ--LRALLVTSKEEK 784
+L E M ++K++ LR++ T K E+
Sbjct: 1673 ILHENLEEMRSVTKERDDLRSVEETLKVER 1702
Score = 66.2 bits (160), Expect = 1e-10
Identities = 140/718 (19%), Positives = 302/718 (42%), Gaps = 129/718 (17%)
Query: 62 KCNEEAKIFLK-DIAVAVKKLEEMRKA---------TIDLLEIESMEL-NKLYYLLETLP 110
K NE I LK D+ KK+ EM + T+ LEIE++ L KL+ LE +
Sbjct: 1826 KANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMK 1885
Query: 111 NSIKR----------------ELEECVRDARRLNLF---EINTIKMRITRTENEIELLKK 151
+ +K +L+E +++ + +L E+ T +M + ++ L++
Sbjct: 1886 SVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLRE 1945
Query: 152 KIT-----------DLTKYNEALGEKQEELARKHARFV-------LSLNQTMEKKATTTV 193
KI+ DL K + L +K +EL +K + + +S + E +
Sbjct: 1946 KISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQ 2005
Query: 194 YINETYTKINLKREDIALQKKCIQEAEEL----------------MEKERAEYLIRKQEL 237
+ + + +++ ++ L KK + EE+ ++ ER +++ +E+
Sbjct: 2006 FEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREM 2065
Query: 238 TAQINEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESI 297
A+ + + KR+ + ++ + L+ K S+IKE + + + DH + RL +
Sbjct: 2066 IARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLK-RYSEMDDHYECLNRLSLDL 2124
Query: 298 RYWEQEVSELKKDLAI-LEAKLC---FFTDNKEKLDDISNDEKNEF---LNKIKQLV--- 347
E+E+ E +K+L++ ++A L T + EKL + EF + K+K ++
Sbjct: 2125 ---EKEI-EFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYV 2180
Query: 348 --------ETLHAARMEYKDLREKMKTL------ARQYKIVLSEEEKAFLQKQKIHDENQ 393
E+++ M++ D EK K L +Q V S E + Q + +
Sbjct: 2181 TKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIE 2240
Query: 394 KQLTFISQKEY---------FLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSAN 444
+ L S+ E+ LS ++ + +EE L T ++++ + ++ +I N
Sbjct: 2241 EILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVN 2300
Query: 445 LERESQRCVITQWKMACLRKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQE 504
+ R + + ++ A + + + +++++ EK + N + +
Sbjct: 2301 -NFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKL------FKNYQTLKTSL 2353
Query: 505 ISGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQ 564
SG AQ+ TT+ + ++ +++ + E + + KE ++++ +
Sbjct: 2354 ASG--AQVNP-TTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKE 2410
Query: 565 LQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQQL 624
L+V + + K+ E + + ++ +L + + L + Y +ED+K +L ++
Sbjct: 2411 LEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKP---YKEEIEDLKMKLVKI 2467
Query: 625 RDQESKKNKDHFETLKNLENGFYINDQKADLLLLENKKLKEYILYLKNNIEKYREGQE 682
D E KN FE I+ KA + + KE I L+ N+ + ++ Q+
Sbjct: 2468 -DLEKMKNAKEFEK--------EISATKATV-----EYQKEVIRLLRENLRRSQQAQD 2511
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 96.3 bits (238), Expect = 1e-19
Identities = 145/686 (21%), Positives = 301/686 (43%), Gaps = 74/686 (10%)
Query: 98 ELNKLYYLLETLPNSIKRELEECV--RDARRLNLFEINTIKMRITRTENEIELLKKKITD 155
EL + + T R +EE RDA L L+ NTI + +N K + +
Sbjct: 180 ELQRALSAVSTRHKKADRYIEELTKERDALSLELYR-NTITNEELKKKNAELQEKLPLAE 238
Query: 156 LTKYNEALGEKQEELARKHARFVLSLNQTMEKKATTTVYINETYTKINLKREDIALQKKC 215
K L K+ + + A+F+L QT N ++ + E++ Q+K
Sbjct: 239 SEKSEIQLNVKELKRKLERAKFLLPQVQT-----------NTLQEEMWRQEEELREQEKK 287
Query: 216 IQEAEELMEKERAEYLIRKQELTAQINEFENTREVKRMETYQKK-----------KELDK 264
I++ EE M ++ E +R+QE + E + R+ KR+ +K+ KEL +
Sbjct: 288 IRKQEEKMWRQ--EERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELRE 345
Query: 265 LQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFFTDN 324
+ +M + +E + + + ++ R E R WEQE K + E K+ D
Sbjct: 346 QEEQMQEQEEKMWEQEEKMREQEEKMWRQEE--RLWEQE-----KQMREQEQKM---RDQ 395
Query: 325 KEKL--DDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLSEEEKAF 382
+E++ D EK E + + +++ E + R E K ++ KT ++ K + EEE+
Sbjct: 396 EERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEK--MQEEERIR 453
Query: 383 LQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILS 442
+++K+ +E + T Q+E Q EE + +E + + + +Q+ K+
Sbjct: 454 EREKKMREEEE---TMREQEEKMQKQ--------EENMWEQEEKEWQQQRLPEQKEKLWE 502
Query: 443 ANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQ 502
+E + + Q + +R + W + K Q EK++ E + E + ++
Sbjct: 503 QEKMQEQEEKIWEQEEK--IRDQEEMWGQEKKMWRQ---EKMREQEDQMWEQEEKMRDQE 557
Query: 503 QEISGFVAQIEKLTTELKEEEKAFVNKEKMLMKE-LSKYEEIFVKETQINKEKEEELVEY 561
Q++ ++EK T E +E+K + +EKM +E + + E+ +E ++ +E+EE++ E
Sbjct: 558 QKMWDQEERMEKKTQE--QEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQ 615
Query: 562 LPQLQVAEQEYKEKRRKLEELSNIITAQR-----QEEDLLNNHIFLFTRDF---SRYISN 613
++Q E++ E+ K++E + Q QEE + ++ +
Sbjct: 616 EEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQE 675
Query: 614 MEDVKQELQQLRDQESKKNKDHFETLKNLENGFYINDQKADLLLLENKKLKEYILYLKNN 673
E ++++ +++ +QE + K + K + ++ + + KK++E ++
Sbjct: 676 QEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQE---KMREEESMREREKKMREEEEMMREQ 732
Query: 674 IEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEF---QTTVKILVDNGEETLQDINNL 730
EK +E +E + ++ Q Q + +W + + K+ + + I
Sbjct: 733 EEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQ 792
Query: 731 TDKLRERDEKMQHVSTWLRGSLEGLR 756
+K+R+++EKM+ +RG E +R
Sbjct: 793 EEKMRDQEEKMRGQEEKMRGQEEKMR 818
Score = 82.4 bits (202), Expect = 2e-15
Identities = 128/697 (18%), Positives = 299/697 (42%), Gaps = 58/697 (8%)
Query: 88 TIDLLEIESMELNKLYYLLETLPNSIKRELEECVRDARRLNLF----EINTIKMRITRTE 143
T + L+ ++ EL + L E+ + I+ ++E R R + NT++ + R E
Sbjct: 219 TNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQE 278
Query: 144 NEIELLKKKITDLTKYNEALGEKQEELARKHARFVLSLNQTMEKKATTTVYINETYTKIN 203
E+ +KKI K E + ++E L + + + + EK + E ++
Sbjct: 279 EELREQEKKIR---KQEEKMWRQEERLREQEGK----MREQEEKMWRQEKRLREQEKELR 331
Query: 204 LKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVKRMETYQKKKELD 263
+ +++ QK+ ++ E++ E+E + +QE + E + R+ +R+ ++++K++
Sbjct: 332 EQEKELREQKELREQEEQMQEQEEKMW---EQEEKMREQEEKMWRQEERL--WEQEKQMR 386
Query: 264 KLQTKMSKIKETVTVSAAVLSDHNL----------EIARLHESIRYWEQEVSELKKDLAI 313
+ + KM +E + L + ++ ++ E + EQE ++ +
Sbjct: 387 EQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKM 446
Query: 314 LEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKI 373
E + + K + ++ + E+ E + K ++ + + + L E+ + L Q K+
Sbjct: 447 QEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKM 506
Query: 374 VLSEEEKAFLQKQKIHDENQ---------KQLTFISQKEYFLSQKRVDIKNMEEGLITLQ 424
+EEK + Q++KI D+ + +Q Q++ Q+ +++ E+ + +
Sbjct: 507 Q-EQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEE-KMRDQEQKMWDQE 564
Query: 425 E-----LQQATKTVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQA 479
E Q+ K + Q+ K+ RE +R + KM ++ + + ++Q
Sbjct: 565 ERMEKKTQEQEKKTWDQEEKM------REEERMREREKKM----REEEEMMREQEEKMQE 614
Query: 480 ITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSK 539
EK+Q E + E E ++QE + + + E K E+ + ++K + E K
Sbjct: 615 QEEKMQEQEEKMWE--QEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEK 672
Query: 540 YEEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNH 599
+E + Q K E+E +E Q Q + +EK R+ E + R+EE+++
Sbjct: 673 MQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQ 732
Query: 600 IFLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNLENGFYINDQKADLLLLE 659
+ E++ ++ +++ +QE K + + + + Q+ + + +
Sbjct: 733 EEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQ 792
Query: 660 NKKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTTVKILVDN 719
+K+++ ++ EK R +E + + Q Q + +W + + +
Sbjct: 793 EEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEK----MWGQ 848
Query: 720 GEETLQDINNLTDKLRERDEKMQHVSTWLRGSLEGLR 756
E+ + + +K+RE++EKM+ +R E +R
Sbjct: 849 EEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMR 885
Score = 62.0 bits (149), Expect = 2e-09
Identities = 95/481 (19%), Positives = 203/481 (42%), Gaps = 104/481 (21%)
Query: 306 ELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAAR-----MEYKDL 360
ELKK A L+ KL ++ EK+E +K+L L A+ ++ L
Sbjct: 222 ELKKKNAELQEKL-----------PLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTL 270
Query: 361 REKM----KTLARQYKIVLSEEEKAFLQKQKIHDENQK---QLTFISQKEYFLSQKRVDI 413
+E+M + L Q K + +EEK + Q++++ ++ K Q + ++E L ++ ++
Sbjct: 271 QEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKEL 330
Query: 414 KNMEEGLITLQELQQATKTVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKI 473
+ E+ L +EL++ + + +Q+ K+ + Q W R++ W +
Sbjct: 331 REQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQE--EKMW-----RQEERLWEQEK 383
Query: 474 KAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKML 533
+ Q +K+++ E R E + R++E ++E+EK + EKM
Sbjct: 384 QMREQE--QKMRDQEERMWE--QDERLREKE------------ERMREQEKMWEQVEKMR 427
Query: 534 MKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEE 593
++ + +E ++ + ++EE + E +++ E+ +E+ K+ Q+QEE
Sbjct: 428 EEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKM---------QKQEE 478
Query: 594 DLLNNHIFLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNLENGFYINDQK- 652
++ E ++E QQ R E K+ E ++ E + ++K
Sbjct: 479 NM------------------WEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKI 520
Query: 653 --------ADLLLLENKKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKD 704
+ + +K++E + EK R+ ++ + + ++ QE K
Sbjct: 521 RDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQE---KK 577
Query: 705 LWAEFQTTVKILVDNGEETLQDINNLTDKLRERDEKMQHVSTWLRGSLEGLRLLVEQESP 764
W + EE +++ +++RER++KM+ +R E ++ EQE
Sbjct: 578 TWDQ------------EEKMRE----EERMREREKKMREEEEMMREQEEKMQ---EQEEK 618
Query: 765 M 765
M
Sbjct: 619 M 619
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 95.9 bits (237), Expect = 1e-19
Identities = 136/684 (19%), Positives = 292/684 (42%), Gaps = 71/684 (10%)
Query: 131 EINTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFVLSLNQTMEKKAT 190
++ ++ R+T TE E + ++ DL + L + QEE ++ + ++ ME
Sbjct: 1265 QVQKLEERLTDTEAEKSQVHTELQDLQRQ---LSQNQEEKSKWEGKQNSLESELME---- 1317
Query: 191 TTVYINETYTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQINE------- 243
++ET + + LQ+ Q EL++ + + + L A + E
Sbjct: 1318 ----LHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASA 1373
Query: 244 ---FENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYW 300
E R K +E++ + + ++E + A +A L +++
Sbjct: 1374 AGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAER 1433
Query: 301 EQEVSELKKDLAILEAKLCFFTDNKEKLDDISND--EKNEFLNKIKQLVETLHAARMEYK 358
E+EV L+ + LE + K L+ +S D ++N+ ++ ++ ++ L R +
Sbjct: 1434 EEEVETLRGQIQELEKQREM---QKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLE 1490
Query: 359 DLREKMKTLARQYKIVLSEEEKAFLQKQKIHDEN--QKQLTFISQKEYFLSQKRVDIKNM 416
L M R+ K+ + E+ L+K + N + QL + +K+ + +R ++++
Sbjct: 1491 HL--PMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDL 1548
Query: 417 EEGLITLQ----ELQQATKTVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAK 472
++ L+TL+ EL++ + QQ I +RE+QR +T + +
Sbjct: 1549 KKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQ------ 1602
Query: 473 IKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKM 532
E+QA + +I + E L E R QE+ QIE+L + + + +++
Sbjct: 1603 ---ELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQE 1659
Query: 533 LMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQE 592
LM + + + + + T+ K EE+L + L+ +E +R+ ++E + +
Sbjct: 1660 LMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKA 1719
Query: 593 EDLLNNHIFLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNLENGFYINDQK 652
+ H+ L RD + + ++ ELQ+L+DQ L+ G + +
Sbjct: 1720 QRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQ-----------LEQQLQGLHRKVGE 1768
Query: 653 ADLLLLENKKLKEYILYLKNNIEKYREG---QEALMHTSNDLSRQLIAQEAQYKDLWAEF 709
LLL + ++ I+ L+ +++ RE +E + + D +++ +AQ Q + +
Sbjct: 1769 TSLLLSQR---EQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQE 1825
Query: 710 QTTVKILVDNGEETLQDINNLTDK----LRERDEKMQHVSTWLRG-----SLEGLRLLVE 760
Q + + +E + ++ L+ER ++Q R ++EG R+
Sbjct: 1826 QQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQAL 1885
Query: 761 QESPMDLL--SKQQLRALLVTSKE 782
+E DL S++Q +ALL ++
Sbjct: 1886 EEVLGDLRAESREQEKALLALQQQ 1909
Score = 80.1 bits (196), Expect = 8e-15
Identities = 159/803 (19%), Positives = 329/803 (40%), Gaps = 109/803 (13%)
Query: 44 EALEQLFVVEQSLQSDYFKCNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKLY 103
+ L++L +L E K+ + K EE+R+ +++LE E+ L ++
Sbjct: 435 QRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQ-LEVLEQEAWRLRRVN 493
Query: 104 YLLETLPNSIKRELEE-------CVRDARRL-------------NLFEINTIKMRITRTE 143
L+ +S + + EE VR+ RL +L E+ T++ + +
Sbjct: 494 VELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSH 553
Query: 144 NEIELLKKKITDLTKYNEALGEKQEELARKHAR-------------FVLSLNQTMEKKAT 190
E ELL+++ T++T AL ++ +A + + L+ E A
Sbjct: 554 LEGELLRQEQTEVTA---ALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALAL 610
Query: 191 TTVYINETYTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQ-------ELTAQINE 243
V +N+ ++ + + + + + ++A ++ + AE R++ L AQ+ +
Sbjct: 611 DKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQK 670
Query: 244 FENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWEQE 303
E + + ++E +++Q K+S+ + + L + E R E + QE
Sbjct: 671 AEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQE 730
Query: 304 VSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDLREK 363
L ++ A LE +L +++ L E+ + L+ K+L+E ++ E +
Sbjct: 731 KEALVREKAALEVRLQAVERDRQDL-----AEQLQGLSSAKELLE---SSLFEAQQQNSV 782
Query: 364 MKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLITL 423
++ Q ++ + +A K+ I E + + + Q+R + L
Sbjct: 783 IEVTKGQLEVQIQTVTQA---KEVIQGEVRCLKLELDTERSQAEQER------DAAARQL 833
Query: 424 QELQQATKTVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAITEK 483
+ +Q KT +QQ A E+E + LR+K W + Q + +
Sbjct: 834 AQAEQEGKTALEQQ----KAAHEKEVNQ----------LREK---WEKERSWHQQELAKA 876
Query: 484 IQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELK--------EEEKAFVNKEKMLM- 534
+++ E ++EL +Q E+ AQ E+ T+ + E EK V+ + L+
Sbjct: 877 LESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQ 936
Query: 535 --KEL---SKYEEIFVKETQINKEKEEELVEYL-PQLQVAEQEYKEKRRKLEELSNIITA 588
KEL S+ E ++ ++ K KE+E L QLQ A++E KE R + ++
Sbjct: 937 TQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAAR--QHRDDLAAL 994
Query: 589 QRQEEDLLNNHIFL--FTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNLENGF 646
Q + LL + + L D + +D ++ ++Q ++ ++ +++ K LE
Sbjct: 995 QEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELER-- 1052
Query: 647 YINDQKADLLL-LENKKLKEYILYLKNNIEK-----YREGQEALMHTSNDLSRQLIAQEA 700
+KA L L L K+ + +L ++I + R+ + +LS Q+
Sbjct: 1053 ----EKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQ 1108
Query: 701 QYKDLWAEFQTTVKILVDNGEETLQDINNLTDKLRERDEKMQHVSTWLRGSLEGLRLLVE 760
+ K+ A+F L++ E + L L ++ K + LR + L L
Sbjct: 1109 EVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAA 1168
Query: 761 QESPMDLLSKQQLRALLVTSKEE 783
++ P + Q A L ++ ++
Sbjct: 1169 EQQPGNQAQAQAQLASLYSALQQ 1191
Score = 78.2 bits (191), Expect = 3e-14
Identities = 172/850 (20%), Positives = 358/850 (42%), Gaps = 171/850 (20%)
Query: 82 EEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEECVRDARR-LNLFEINTIKMRIT 140
+E+ KA ++ LE E MEL +T +I+ + EE A L ++ T K R++
Sbjct: 871 QELAKA-LESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVS 929
Query: 141 RTENEIELLKKKITDLTKYNEALGE--KQEELARKHARFVLSLNQTMEKKATTTVYINET 198
E ++ +K++ D ++ E L + K ++L + +L QT ++A E
Sbjct: 930 LLETLLQT-QKELADASQQLERLRQDMKVQKLKEQETTGIL---QTQLQEAQ-----REL 980
Query: 199 YTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVKRMETYQK 258
R+D+A +QE + +++ + + ++L +Q+ ++++ + E +K
Sbjct: 981 KEAARQHRDDLA----ALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEK 1036
Query: 259 KKEL---DKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILE 315
+E +++Q ++ + K ++T+S + + L + + +SIR +QE+S L++D+ +
Sbjct: 1037 LRETQEYNRIQKELEREKASLTLSL-MEKEQRLLVLQEADSIR--QQELSALRQDMQEAQ 1093
Query: 316 AKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKM---KTLARQYK 372
+ + E L +++ +FL + QL+E L A+ + + LR + + A Q +
Sbjct: 1094 GEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQ 1153
Query: 373 IVLSEEE---KAFLQKQKIHDENQKQLTFIS------QKEYFLSQKRVDIKNMEEGLITL 423
+ L E +A +Q+ ++ Q Q S Q + + R ++ + ++
Sbjct: 1154 LRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSV 1213
Query: 424 QELQ--------------------------------------QATKTVYQQQIKILSANL 445
L+ Q T+ V + Q++ L L
Sbjct: 1214 WGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERL 1273
Query: 446 -ERESQRCVI------TQWKMACLRKKHARWTAK---IKAEIQAITE-------KIQNAE 488
+ E+++ + Q +++ +++ ++W K +++E+ + E +++ AE
Sbjct: 1274 TDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAE 1333
Query: 489 VRRIELLNETSFRQQEISGFVAQIEKL--------------------------TTELKEE 522
++R+E E Q AQ+E L +LK E
Sbjct: 1334 LQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNE 1393
Query: 523 EKAFVNKEKMLMKELSKYEEIFVKE-----------TQINKEKEEELVEYLPQLQVAEQE 571
E V E+ + L + E+ V + TQ E+EEE+ Q+Q E++
Sbjct: 1394 E---VESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQ 1450
Query: 572 YKEKRRKLEELSNIITAQRQEEDL-------------LNNHIFLFTRDFSRYISNMEDVK 618
+ ++ LE LS + + QE DL + H+ + ++ + ++ +
Sbjct: 1451 REMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQI 1510
Query: 619 QELQQLRDQESKKNKDHFETLKNLENGFYINDQKAD---------------LLLLENKKL 663
+EL+ +D+E+++N + L+ + I Q+ L L EN
Sbjct: 1511 RELE--KDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHK 1568
Query: 664 KEYILYLKNNIEKYREGQE-ALMHTSNDL---SRQLIAQEAQYKDLWAEFQTTVKILVDN 719
E L +E RE Q AL H + DL S++L AQ +Q DL E +TV L
Sbjct: 1569 MECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDL--ESHSTV--LARE 1624
Query: 720 GEETLQDINNLTDKLRERDEKMQHVSTWLRGSLEGLRLLVEQESPMDLLSKQQLRALLVT 779
+E Q++ + +++ E + +H++ L + L L Q+ + +L Q+ R +
Sbjct: 1625 LQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELML---QKERIQVLEDQRTRQTKIL 1681
Query: 780 SKEEKTCQLS 789
++ + +LS
Sbjct: 1682 EEDLEQIKLS 1691
Score = 73.6 bits (179), Expect = 7e-13
Identities = 151/724 (20%), Positives = 293/724 (40%), Gaps = 118/724 (16%)
Query: 47 EQLFVVEQSLQSDYFKCNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLL 106
E L ++ Q+L EE L+ ++K EM+KA ++LL S++L K +
Sbjct: 1421 ENLALLTQTLAE-----REEEVETLRGQIQELEKQREMQKAALELL---SLDLKKRNQEV 1472
Query: 107 ETLPNSIKRELEECVRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEALGEK 166
+ I+ ELE+C L M + E ++ + +++I +L K E
Sbjct: 1473 DLQQEQIQ-ELEKCRSVLEHL--------PMAVQEREQKLTVQREQIRELEKDRET---- 1519
Query: 167 QEELARKHARFVLSLNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKE 226
R VL +Q +E + + ++ +LK++ + L+ ++ E + E
Sbjct: 1520 --------QRNVLE-HQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKME 1570
Query: 227 RAEYLIRKQELTAQINEFENTREVKR-------METYQKKKELDKLQTKMSKIKETVTVS 279
+ LI+ E E RE +R ++ ++ +EL +++ ++ TV
Sbjct: 1571 CQQKLIK---------ELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVL 1621
Query: 280 AAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEF 339
A L + + E+ E I +++ L +DL + +L + + L+D +
Sbjct: 1622 ARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLED-------QR 1674
Query: 340 LNKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFI 399
+ K L E L ++ ++ R + T RQ +EE K + Q+ E+ K +
Sbjct: 1675 TRQTKILEEDLEQIKLSLRE-RGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLI--- 1730
Query: 400 SQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQ---QQIKILSANLERESQRCVITQ 456
L K +++ +E + LQEL+ + Q +++ S L + Q V+ Q
Sbjct: 1731 ------LRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQ 1784
Query: 457 WKMACLRKKHARWTAKIKAE-IQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKL 515
++ + AR ++K + +Q+ ++ Q A +R + L QQ+ G ++++
Sbjct: 1785 QQL-----QEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEK 1839
Query: 516 TTELKEEEKAFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQ----- 570
L+ + + M +KE ++ E+ + Q + +EE VE ++Q E+
Sbjct: 1840 ADALQ----GALEQAHMTLKE--RHGELQDHKEQARRLEEELAVEGR-RVQALEEVLGDL 1892
Query: 571 --EYKEKRRKLEELSNIITAQRQEEDL---------LNNHIFLFTRDFSRYISNMEDVKQ 619
E +E+ + L L Q QE ++ L L RD +E ++
Sbjct: 1893 RAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERD-----QELEALRA 1947
Query: 620 ELQQLRDQESKKNKDHFETLKNLENGFYINDQKADLLLLENKKLKEYILYLKNNIEKYRE 679
E Q R QE + E L+ + Q + LLE +L L+ + +
Sbjct: 1948 ESQSSRHQEEAA-RARAEALQEALGKAHAALQGKEQHLLEQAELSRS---LEASTATLQA 2003
Query: 680 GQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTTVKILVDNGEETLQDINNLTDKLRERDE 739
+A S L L QE + +D +Q +D+ L L +RDE
Sbjct: 2004 SLDACQAHSRQLEEALRIQEGEIQDQDLRYQ--------------EDVQQLQQALAQRDE 2049
Query: 740 KMQH 743
+++H
Sbjct: 2050 ELRH 2053
Score = 56.6 bits (135), Expect = 9e-08
Identities = 129/738 (17%), Positives = 309/738 (41%), Gaps = 99/738 (13%)
Query: 78 VKKLEEMRKATIDLLEIESMELNKLYYLLETLPNSI---KRELE--ECVRDARRLNLFEI 132
+++LE+ R+ ++LE + +EL K ++E+ + K++L EC+ N ++
Sbjct: 1510 IRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKM 1569
Query: 133 NTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFVLSLNQTMEKKATTT 192
+ I E + E + +T LT L E+ +EL + ++ +E +T
Sbjct: 1570 ECQQKLIKELEGQRETQRVALTHLTL---DLEERSQELQAQSSQI-----HDLESHSTVL 1621
Query: 193 VY-INETYTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVK 251
+ E ++ +RE I ++ + + +E+ E +++K+ + Q+ E + TR+ K
Sbjct: 1622 ARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERI--QVLEDQRTRQTK 1679
Query: 252 RMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDH-------------NLEIARL----- 293
+E ++L++++ + + +T ++ + +LE +L
Sbjct: 1680 ILE-----EDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDK 1734
Query: 294 HESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAA 353
+ + ++ + EL++ LE +L + + + + E + +QL E
Sbjct: 1735 EKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQG 1794
Query: 354 RMEYKDLREKMKTLAR-------QYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFL 406
++ + L+ ++ R + + + E+++A Q++++ ++ + Q L
Sbjct: 1795 ELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTL 1854
Query: 407 SQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSANLERESQRCVITQWKMACLRKKH 466
++ ++++ +E L+E + A + Q ++ + +L ES+ + + L+++
Sbjct: 1855 KERHGELQDHKEQARRLEE-ELAVEGRRVQALEEVLGDLRAESRE---QEKALLALQQQC 1910
Query: 467 ARWTAKIKAEIQAITE---------KIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTT 517
A + + E +A+ + K ++ E+ + +++S Q+E + A+ E L
Sbjct: 1911 AEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAAR--ARAEALQE 1968
Query: 518 ELKEEEKAFVNKEKMLMK--ELSKY-----------------------EEIFVKETQINK 552
L + A KE+ L++ ELS+ E + ++E +I
Sbjct: 1969 ALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQD 2028
Query: 553 E--KEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRY 610
+ + +E V+ L Q E +++ E+L AQR +E+++ L
Sbjct: 2029 QDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEE 2088
Query: 611 ISNMEDVKQEL--------QQLRDQESKKNKDHFETLKNLENGFYINDQKADLLLLENKK 662
I + +EL Q++ + + +++ E L + + +Q L LE +
Sbjct: 2089 IRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLE-PR 2147
Query: 663 LKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLW--AEFQTTVKILVDNG 720
L+ + L+ + + + + DL+ L +A L A F + D+
Sbjct: 2148 LQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSE 2207
Query: 721 EETLQDINNLTDKLRERD 738
++ LQD LT + E++
Sbjct: 2208 QQRLQDELELTRRALEKE 2225
Score = 45.1 bits (105), Expect = 3e-04
Identities = 98/540 (18%), Positives = 218/540 (40%), Gaps = 72/540 (13%)
Query: 254 ETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARL----HESIRYWEQEVSELKK 309
+T + +KE + ++ ++K + A L D E++ L + +E+ + L++
Sbjct: 252 KTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRE 311
Query: 310 DLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLAR 369
+ ILE +++ L + +EK IK + + + E+ +A+
Sbjct: 312 TVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQV----------MVEEGDNIAQ 361
Query: 370 QYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLITLQE---L 426
S E + + Q + + K LT + L+++R ++++ + L QE L
Sbjct: 362 GSGHENSLELDSSIFSQFDYQDADKALTLVRS---VLTRRRQAVQDLRQQLAGCQEAVNL 418
Query: 427 QQATKTVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAITEKIQN 486
Q ++++ K L L+ K+ R A T ++ E+ +++++ +
Sbjct: 419 LQQQHDQWEEEGKALRQRLQ-----------KLTGERDTLAGQTVDLQGEVDSLSKEREL 467
Query: 487 AEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSKYEEIFVK 546
+ R EL + +QE ++ ++ EL+ + + +++ +EL + V+
Sbjct: 468 LQKAREELRQQLEVLEQE----AWRLRRVNVELQLQGDSAQGQKEEQQEEL----HLAVR 519
Query: 547 ETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHI--FLFT 604
E E L E L L+ ++ E LS +IT + E L ++H+ L
Sbjct: 520 E-------RERLQEMLMGLEA---------KQSESLSELITLR---EALESSHLEGELLR 560
Query: 605 RDFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNLENGFYINDQKADLLLLENKKLK 664
++ + + + +Q + +L E+ + + +L + L L+ L
Sbjct: 561 QEQTEVTAALARAEQSIAELSSSENTLKTE----VADLRAAAVKLSALNEALALDKVGLN 616
Query: 665 EYILYLKNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTTVKILVDNGEET- 723
+ +L L+ + EA N L L E + + LW E T ++ + EE
Sbjct: 617 QQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALW-EKNTHLEAQLQKAEEAG 675
Query: 724 ------LQDINNLTDKLRERDEKMQHVSTWLRGSLEGLRLLVEQESPMDLLSKQQLRALL 777
L+DI ++++++ + +H LE L +++ + + Q+ AL+
Sbjct: 676 AELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALV 735
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 95.9 bits (237), Expect = 1e-19
Identities = 177/807 (21%), Positives = 336/807 (41%), Gaps = 88/807 (10%)
Query: 40 SVAVEALEQLFVVE-QSLQSDYFKCNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIESME 98
S VE LE V E QSLQ+ C +K +K+ A K +E +R+ + ++I E
Sbjct: 504 SKKVEILENEIVQEKQSLQN----CQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQE 559
Query: 99 LNKLYYLLETLPNSIKRELEECVRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTK 158
L + +L + E V+D + N +IK ++ ++IE K++I +
Sbjct: 560 NEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKL-SKIEFEKRQIKKELE 618
Query: 159 YNEALGEKQEELARKHARFVLSLNQTMEKKATTTVYINETYTKIN-----LKREDIALQK 213
+ + GE+ EEL + + N+ ++KK T E + L+RE+ L+K
Sbjct: 619 HYKEKGERAEELENE-LHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKK 677
Query: 214 -----KCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVKRMETYQKKKELDKLQTK 268
K + E +EKE ++ EL + + +K + + KEL+ + +
Sbjct: 678 TLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLK-CASMKMAQLQLENKELESEKEQ 736
Query: 269 MSKIKETVTVS-------AAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFF 321
+ K E + S ++E RL +++ +++ +L+ +L LE +
Sbjct: 737 LKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTL 796
Query: 322 TDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKIV------- 374
N E+L IS+ + + K L + + K L ++ K L +Q +I
Sbjct: 797 QKNLEELK-ISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEEN 855
Query: 375 ------LSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKR-VDIKNMEEGLITLQELQ 427
L +E K ++ I+ E+ +L + ++ L ++ +DIK L+TL+E
Sbjct: 856 NVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKT----LVTLREDL 911
Query: 428 QATKTVYQQQ---IKILSANLER---ESQRCVITQWKMACLRKK--HARWTAKIKAEIQA 479
+ K QQ ++ L+ LE+ +R + + R K ++ + +K ++
Sbjct: 912 VSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEI 971
Query: 480 ITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSK 539
EKI E R E N +QE+ E L + +++E+ V + E +K
Sbjct: 972 KEEKIAALEARLEESTNYNQQLRQELKTVKKNYEAL--KQRQDEERMVQSSPPISGEDNK 1029
Query: 540 YEEIFVKETQINKEKEEELVEYLPQ---LQVAEQEYKEKRRKLEELSN-----IITAQRQ 591
+E + T+ + ++ L+E LQ +Q K + ++LE +N I+ QRQ
Sbjct: 1030 WERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQ 1089
Query: 592 EEDLLNNHIFLFTRDFSRYISNM-------EDVKQELQQLRDQESKKNKDHF-----ETL 639
L + L T++ + N + Q Q L Q S +N++ E L
Sbjct: 1090 TVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDL 1149
Query: 640 KNLENGFYINDQKADLLLLENKKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIAQE 699
K+L + + +K +LL E ++ ++ + E D QL+ Q+
Sbjct: 1150 KSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQK 1209
Query: 700 AQYKDLWAEFQT-TVKILVDNGEETLQDINNLTDKLRERDEKMQHVSTWLRGSLEGLRLL 758
Q +DL + K+L++N + + + KL ++++ H + L E L+
Sbjct: 1210 GQLEDLEKMLKVEQEKMLLEN--KNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQ-- 1265
Query: 759 VEQESPMDLLSKQQLRALLVTSKEEKT 785
+ L++LL SK E+T
Sbjct: 1266 ---------TDHKNLKSLLNNSKLEQT 1283
Score = 82.0 bits (201), Expect = 2e-15
Identities = 136/640 (21%), Positives = 276/640 (43%), Gaps = 95/640 (14%)
Query: 186 EKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQINEFE 245
E + +V + + KI R+++ + + + + ++ +E+ E +QE +++
Sbjct: 244 ESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDAR 303
Query: 246 NTREVK-RMETYQKKK-ELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWEQE 303
+ R + ++ ++K +DKL++++S+ KE RLH+ I +++
Sbjct: 304 SARMYRDELDALREKAVRVDKLESEVSRYKE-----------------RLHD-IEFYKAR 345
Query: 304 VSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARME------- 356
V ELK+D +L D E S D+ +E + QL LH ME
Sbjct: 346 VEELKEDNQVLLETKTMLEDQLEGTRARS-DKLHELEKENLQLKAKLHDMEMERDMDRKK 404
Query: 357 YKDLREKMKTLARQYKIVLSE------EEKAFLQKQKIHDENQKQLTFISQKEYFLSQKR 410
++L E+ TL K + E E + + ++ + QK L + S +
Sbjct: 405 IEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGH--EVNELTSSRL 462
Query: 411 VDIKNMEEGLI-TLQELQQATKTVYQQQIKILSANLERESQRCV---------ITQWKMA 460
+ ++ + L T++EL+ +V KIL +E+E+QR I Q K +
Sbjct: 463 LKLEMENQSLTKTVEELRTTVDSVEGNASKILK--MEKENQRLSKKVEILENEIVQEKQS 520
Query: 461 CLRKKH-ARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTEL 519
++ ++ K KA+++ E ++ R+I++L + + + + Q +++ E
Sbjct: 521 LQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEA 580
Query: 520 KEEEKAFVNK--EKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRR 577
+ ++ NK + + + SK +I ++ QI KE E YKEK
Sbjct: 581 RVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEH---------------YKEKGE 625
Query: 578 KLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFE 637
+ EEL N + +E +LL I + +E ++QE +L ++E++K K +
Sbjct: 626 RAEELENELHHLEKENELLQKKI----TNLKITCEKIEALEQENSEL-ERENRKLKKTLD 680
Query: 638 TLKNLENGFYINDQKADLLLLENKKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIA 697
+ KNL + + L EN +L E L L+ N+E + + + +++L +
Sbjct: 681 SFKNL-------TFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLE-NKELES 732
Query: 698 QEAQYKD----LWAEFQTTVKILV---------DNGEETLQDINNLTDKLRERDEKMQHV 744
++ Q K L A F+ T ++ V ++TL++ N +L + ++
Sbjct: 733 EKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEME 792
Query: 745 STWLRGSLEGLRLLVEQESPMDLLSKQQLRALLVTSKEEK 784
+ L+ +LE L++ ++ L K+ TS+ EK
Sbjct: 793 NQTLQKNLEELKI---SSKRLEQLEKENKSLEQETSQLEK 829
Score = 74.3 bits (181), Expect = 4e-13
Identities = 165/767 (21%), Positives = 322/767 (41%), Gaps = 120/767 (15%)
Query: 43 VEALEQLFVVEQSLQSDYFKCNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKL 102
++AL + V L+S+ + E L DI ++EE+++ LLE ++M ++L
Sbjct: 312 LDALREKAVRVDKLESEVSRYKER----LHDIEFYKARVEELKEDNQVLLETKTMLEDQL 367
Query: 103 YYLLETLPNSIKRELEECVRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEA 162
E R AR L E+ E E LK K+ D+ +
Sbjct: 368 ----------------EGTR-ARSDKLHEL----------EKENLQLKAKLHDMEMERDM 400
Query: 163 LGEKQEELARKHARFVLSLNQTMEKKATTTVYINETYTKINLKRE-DIALQKKCIQEAEE 221
+K EEL ++ ++ Q+M++ ++++ +I+ E A QK E E
Sbjct: 401 DRKKIEELMEENMTLEMAQKQSMDE----SLHLGWELEQISRTSELSEAPQKSLGHEVNE 456
Query: 222 LMEKERAEYLIRKQELTAQINEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAA 281
L + + Q LT + E T V +E K KM K + ++
Sbjct: 457 LTSSRLLKLEMENQSLTKTVEELRTT--VDSVEGNASK------ILKMEKENQRLSKKVE 508
Query: 282 VLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKE---KLDDISNDEKNE 338
+L + EI + +S++ + +L K+ A LE + +N E K+ + N+ N+
Sbjct: 509 ILEN---EIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQ 565
Query: 339 FLNKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTF 398
++ ++Q + AR+ KD+ ++ K L K S+ K +K++I +K+L
Sbjct: 566 TVSSLRQRSQISAEARV--KDIEKENKILHESIKETSSKLSKIEFEKRQI----KKELEH 619
Query: 399 ISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQ--QQIKILSANLERESQRCVIT- 455
+K + ++ ++E+ LQ+ K + + ++ ++ LERE+++ T
Sbjct: 620 YKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTL 679
Query: 456 ------QWKMACLRKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFV 509
+++ L K++++ + E++ E ++ A ++ +L E + E
Sbjct: 680 DSFKNLTFQLESLEKENSQLDEE-NLELRRNVESLKCASMKMAQLQLENKELESEKEQLK 738
Query: 510 AQIEKLTTELKEEEKAFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAE 569
+E L K+ E+ V+ + + E +++T N K+ + +E +LQ E
Sbjct: 739 KGLELLKASFKKTERLEVSYQGL------DIENQRLQKTLENSNKKIQQLE--SELQDLE 790
Query: 570 QEYKEKRRKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQQLRDQES 629
E + ++ LEEL I+++R E+ + ++E +L++ + Q
Sbjct: 791 MENQTLQKNLEELK--ISSKRLEQ-------------LEKENKSLEQETSQLEKDKKQLE 835
Query: 630 KKNKDHFETLKNLENGFYINDQKADLLLLENKKLKEYILYLKNNIEKYREGQEALMHTSN 689
K+NK + + + N+ K L ENK L + I K + + +E ++
Sbjct: 836 KENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKE------ 889
Query: 690 DLSRQLIAQEAQYKDLWAEFQTTVKILVDNGEETL--QDINNLTDKLRERDEKMQHVSTW 747
+++L+ K + +T V + D E L Q +NN +KL EK+
Sbjct: 890 --NKELV------KRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKI------ 935
Query: 748 LRGSLEGLRLLVEQESPMD---LLSKQQLRALLVTS---KEEKTCQL 788
L RLL +++S D L + +L + L S KEEK L
Sbjct: 936 ---GLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAAL 979
Score = 64.7 bits (156), Expect = 3e-10
Identities = 102/532 (19%), Positives = 225/532 (42%), Gaps = 64/532 (12%)
Query: 65 EEAKIFLKDIAVAVKKLEEMRKATI-DLLEIESM--ELNKLYYLLETLPNSIKREL-EEC 120
+E K +K + +K L +R+ + + L+ + M +L KL + LE + + +R L +E
Sbjct: 888 KENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQ 947
Query: 121 VRDARRLNLFEI---NTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARF 177
D R L E +T+K + E +I L+ ++ + T YN+ L ++ + + + +
Sbjct: 948 STDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYE-- 1005
Query: 178 VLSLNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKER--AEYLIRKQ 235
L Q E+ ++ I+ K +RE ++ ++ + L+E ER A KQ
Sbjct: 1006 ALKQRQDEERMVQSSPPISGEDNK--WERESQETTRELLKVKDRLIEVERNNATLQAEKQ 1063
Query: 236 ELTAQINEFENTRE-------VKRMETYQKKKELDKLQTKMSKIK---ETVTVSAAVLSD 285
L Q+ + E + +T +++ LQT+ +K++ T+ + L +
Sbjct: 1064 ALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMN 1123
Query: 286 HNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQ 345
N ++ S+ + V + ++DL L L + E L + E ++K
Sbjct: 1124 QNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGT 1183
Query: 346 LVETLHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYF 405
L +E++DL ++ L +Q + E+ ++++K+ EN+ T ++ +
Sbjct: 1184 LKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKL 1243
Query: 406 LSQKRVDIKNMEEGLITLQELQQATKTVY--QQQIKILSANLERESQRCVITQWKMACLR 463
+ D N T +L + T+ + + +K L N + E R
Sbjct: 1244 CGEN--DRLNH-----TYSQLLKETEVLQTDHKNLKSLLNNSKLEQTR------------ 1284
Query: 464 KKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEE 523
++AE + E+ Q ++ +L N+ + +L L+EE
Sbjct: 1285 ---------LEAEFSKLKEQYQQLDITSTKLNNQCEL-----------LSQLKGNLEEEN 1324
Query: 524 KAFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEK 575
+ +++ + LM + E ++ + ++ + ++ L +L+ +++ +EK
Sbjct: 1325 RHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEK 1376
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 95.5 bits (236), Expect = 2e-19
Identities = 172/772 (22%), Positives = 325/772 (42%), Gaps = 119/772 (15%)
Query: 32 TLPSTLGSSVAVEALE---QLFVVEQSLQS------DYFKCNEEAKIFLKDIAVAVKKLE 82
TL ++ SS A + L+ Q+ +Q L+ DY K E D + + L+
Sbjct: 250 TLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKE-------DFTMQISFLQ 302
Query: 83 EMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEECVRDARRLNLFEINTIKMRITRT 142
E +++ ME +K + NS K E++E + + E+NT +I
Sbjct: 303 EK-------IKVYEMEQDK------KVENSNKEEIQE-----KETIIEELNT---KIIEE 341
Query: 143 ENEIELLKKKITDLTKYNEALGEKQEELARKHARFV---LSLNQTMEKKATTTVYINETY 199
E + LK K+T K LGE QE++ +K+ L L + +K+ ++ I +
Sbjct: 342 EKKTLELKDKLTTADKL---LGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLM 398
Query: 200 TKIN----------------LKREDIALQKKCIQEAEELMEKERAEYLIRKQELT----A 239
+ ++R + Q+K Q EL E + + KQEL A
Sbjct: 399 GTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMA 458
Query: 240 QINEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRY 299
Q+ E + + + + + + ++ + + L D N + +L E +
Sbjct: 459 QMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGL 518
Query: 300 WEQEVSELKKDLAILEAKLCFFTDNKEKL------DDISNDEKNEFLNKIKQLVETLHAA 353
+E L++ L L +L F + ++ + +E ++ L+ ++ L + +A
Sbjct: 519 ILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSA 578
Query: 354 RMEYKDLREKMKTLARQYKI---VLSEEEKAFLQKQKIHDENQ-----KQLTFISQKEYF 405
K+L K + YKI +L +E+ A L + E + QL F ++E
Sbjct: 579 SESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEE-- 636
Query: 406 LSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSANLERESQRCVITQWKMACLRKK 465
LS+ + D++ E I +++L+ Y+QQI L + SQ+ Q++ L K
Sbjct: 637 LSKLKEDLEI--EHRINIEKLKDNLGIHYKQQIDGLQNEM---SQKIETMQFEKDNLITK 691
Query: 466 HARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKA 525
+ +I ++++ + + + N++ + L +I+ +IE L E E+EK
Sbjct: 692 QNQLILEI-SKLKDLQQSLVNSKSEEMTL---------QINELQKEIEILRQE--EKEKG 739
Query: 526 FVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSNI 585
+ +E ++EL E+ K+ KEKE +L E QL+ K++++ LE++ I
Sbjct: 740 TLEQE---VQELQLKTELLEKQM---KEKENDLQEKFAQLEAENSILKDEKKTLEDMLKI 793
Query: 586 ITAQRQEEDLL-------NNHIFLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFET 638
T QEE L+ + ++ ++ I ED+KQ+ QL ++ K+
Sbjct: 794 HTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFA 853
Query: 639 LKNLENGFY-INDQKADLLLLENKKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIA 697
KN E + + ++ A LL K+K+ + KN E + + ++ L R
Sbjct: 854 EKNFEVNYQELQEEYACLL-----KVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPT 908
Query: 698 QEAQYKDLWAEFQTTVKILVDNGEETLQDINNLTDKL----RERDEKMQHVS 745
++ E +T V ++ GE +D L +KL RE+ E Q +S
Sbjct: 909 TVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLS 960
Score = 77.8 bits (190), Expect = 4e-14
Identities = 142/611 (23%), Positives = 263/611 (43%), Gaps = 113/611 (18%)
Query: 220 EELMEKERAEYLIRKQE-----LTAQINEFENTREVKRMETYQKKKELDKLQTKMSKIKE 274
E L + + E I++++ LTA + + ++ E + ++ KLQ + +++
Sbjct: 188 EGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQA 247
Query: 275 TVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFFT------DNKEKL 328
+ T+ + S ++ + + I +Q++ E L + K FT K K+
Sbjct: 248 SETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKV 307
Query: 329 DDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKI-----VLSEEEKAFL 383
++ D+K E NK + + + K + E+ KTL + K+ +L E ++ +
Sbjct: 308 YEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIV 367
Query: 384 QKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSA 443
QK + + +LT QKE Q +IK + + T++ELQ+ Q + I+
Sbjct: 368 QKNQEIKNMKLELTNSKQKE---RQSSEEIKQL---MGTVEELQKRNHKDSQFETDIVQ- 420
Query: 444 NLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQ 503
+E+E+QR K+ LR AE+ + +Q+
Sbjct: 421 RMEQETQR------KLEQLR-----------------------AELDEMYGQQIVQMKQE 451
Query: 504 EISGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLP 563
I +AQ+E++ T K E + L Y I V E QI + + +
Sbjct: 452 LIRQHMAQMEEMKTRHKGE----------MENALRSYSNITVNEDQI-----KLMNVAIN 496
Query: 564 QLQVAEQEYKEKRRKLEELSNII-----TAQRQEEDLLNNHIFLFTRDFSRYISNMEDVK 618
+L + Q+ ++ KL+E +I QRQ EDL+ FSR E ++
Sbjct: 497 ELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEE------LSFSR-----EQIQ 545
Query: 619 QELQQLRDQESKKNKDH--FETLKNLENGFY-INDQKADLLL-----LENKKLKEYILYL 670
+ Q + +QESK N+ H T+++L+ ++ + +L L + N K+K +L
Sbjct: 546 RARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEK 605
Query: 671 KNN--IEKYREGQEALMHTSNDLSRQLIAQEAQ-----YKDLWAEFQTTVKILVDN-GEE 722
+ N +++ E QEA + L QL+ + +DL E + ++ L DN G
Sbjct: 606 EKNAVLDRMAESQEAELER---LRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIH 662
Query: 723 TLQDINNLTDKLRERDEKMQHVSTWLRGSLEGLRLLVEQESPMDLLSK-QQLRALLVTSK 781
Q I+ L +++ ++ E MQ E L+ +Q + +SK + L+ LV SK
Sbjct: 663 YKQQIDGLQNEMSQKIETMQ---------FEKDNLITKQNQLILEISKLKDLQQSLVNSK 713
Query: 782 -EEKTCQLSDL 791
EE T Q+++L
Sbjct: 714 SEEMTLQINEL 724
Score = 77.8 bits (190), Expect = 4e-14
Identities = 155/751 (20%), Positives = 308/751 (41%), Gaps = 112/751 (14%)
Query: 44 EALE-QLFVVEQSLQSDYFKCNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKL 102
+ALE QL + + L E +F ++I +KLE+ K I + ++
Sbjct: 2056 QALEKQLEKMRKFLDEQAIDREHERDVFQQEI----QKLEQQLKVVPRFQPISEHQTREV 2111
Query: 103 YYLLETLPNSIKRELEECVRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEA 162
E L N +K + ++C L ++ I EIE L+ ++ +L +
Sbjct: 2112 ----EQLANHLKEKTDKCSE-----LLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLV 2162
Query: 163 LGEKQEELA-RKHARFVLSLNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEE 221
+ +++ RKH V + + + + V + I+ K ++I ++ +++ E
Sbjct: 2163 SADTFQKVEDRKHFGAVEA-----KPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFRE 2217
Query: 222 LMEKERAEYLIRKQELTAQINEFENTREVKRMETYQK--KKELDKLQTKMSKIKETVTVS 279
+E + E +++ + +I + E+T ++ +E K K +++KL IKE+ +S
Sbjct: 2218 ELENKNEE--VQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLA---IKESDAMS 2272
Query: 280 AAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEF 339
D ++ + + I+ E E+ +L + + L+ +L TDNK +EKNE
Sbjct: 2273 T---QDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVI------EEKNEL 2323
Query: 340 LNKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFI 399
+ +DL +++ L + V E+ Q ++ ++ Q++L I
Sbjct: 2324 I-----------------RDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANI 2366
Query: 400 SQKE----YFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSANLERESQRCVIT 455
QK + LS++ +K+ + +I A K +QQ++ +AN E + V+
Sbjct: 2367 GQKTSMNAHSLSEEADSLKHQLDVVI-------AEKLALEQQVE--TANEEMTFMKNVLK 2417
Query: 456 QWKMACLRKKHARWTAKIKAE----IQAITEKIQNAEVRRIE-----------------L 494
+ + ++ K + E IQ+I E N + + L
Sbjct: 2418 ETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSL 2477
Query: 495 LNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKML---------MKELSKYEEIFV 545
N+T F+ E +G I L T L + E K+ L M+E ++E +
Sbjct: 2478 ENQTYFKSFEENG-KGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEML 2536
Query: 546 KETQINKEK---EEELVEYLPQLQV-AEQEYKEKRRKLEELS------NIITAQRQEEDL 595
++ +N +K E+ + Q+Q+ A QEY + + + +S NI + ED
Sbjct: 2537 QKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDE 2596
Query: 596 LNNHIFLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNL-ENGFYINDQKAD 654
L + I T S S + ++ L ++Q K+ E K L E + +
Sbjct: 2597 LGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKK 2656
Query: 655 LLLLENKKLKEYILYLKNNIEKYREGQEA-LMHTSNDLSRQLIAQEAQ---YKDLWAEFQ 710
E K+ + + LK E + +E+ + L + +A +A+ YK+ + Q
Sbjct: 2657 QREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQ 2716
Query: 711 TTVKILVDNGEETLQDINNLTDKLRERDEKM 741
+ + N +D++ + D L E EK+
Sbjct: 2717 EELLVKETNMTSLQKDLSQVRDHLAEAKEKL 2747
Score = 63.2 bits (152), Expect = 1e-09
Identities = 148/746 (19%), Positives = 311/746 (41%), Gaps = 84/746 (11%)
Query: 71 LKDIAVAVKKLEEMRKATIDLLEIESMELNKL-YYLLETLPNSIKRELE-----ECVRD- 123
L+++ ++++E R+ E E + LL+ +K +LE E VRD
Sbjct: 1959 LQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDD 2018
Query: 124 -ARRLNLFEINTIKMRITRTENEIELLKKKIT---DLTKYNEALGEKQEELARKHARFVL 179
+++ EI+ ++ +++R IEL ++K T DL + N+AL EKQ E RK
Sbjct: 2019 LQKQVKALEID-VEEQVSRF---IELEQEKNTELMDLRQQNQAL-EKQLEKMRKF----- 2068
Query: 180 SLNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTA 239
++++A + + + + K E Q E +E + +E T
Sbjct: 2069 -----LDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTD 2123
Query: 240 QINEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRY 299
+ +E ++E + + ++ +E++KL+ ++ ++++ + VSA R H
Sbjct: 2124 KCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVE---DRKHFGAVE 2180
Query: 300 WEQEVS---ELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARME 356
+ E+S +L+ + ++ K T+ +E+L+ + E NK +++ + ++
Sbjct: 2181 AKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQF----REELENKNEEVQQLHMQLEIQ 2236
Query: 357 YKDLREKMKTLARQYKIVLSEEEKAFLQ-KQKIHDENQKQLTFISQKEYFLSQKRVDIKN 415
K+ +++ L ++ K+ + EK L K+ Q Q + + +K V+I
Sbjct: 2237 KKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQ 2296
Query: 416 MEEGLITLQELQQATKTVYQQQIKILSAN--LERESQRCVITQWKMACLRKKHARWTAKI 473
+ E Q TK QQQ+KI + N +E +++ + ++ CL
Sbjct: 2297 LNE---------QVTK--LQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNR 2345
Query: 474 KAEIQAITEKIQNAEVRRIELLNETSFR----QQEISGFVAQIEKLTTE--LKEEEKAFV 527
+ EI+ + E I+ + + +TS +E Q++ + E E++
Sbjct: 2346 EEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETA 2405
Query: 528 NKEKMLMKELSKYEEIFVKETQINKE-----KEEELVEYLPQL-----QVAEQEYKEKRR 577
N+E MK + K E K Q+ +E +E E VE + + VA + +
Sbjct: 2406 NEEMTFMKNVLK--ETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKP 2463
Query: 578 KLE---------ELSNIITAQRQEEDLLNNHIFLFTR--DFSRYISNME-DVKQELQQLR 625
+LE L N + EE+ + I L TR +S + ++ Q +Q++
Sbjct: 2464 ELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIK 2523
Query: 626 DQESKKNKDHFETLKNLENGFYINDQKADLLLLENKKL---KEYILYLKNNIEKYREGQE 682
D + + + K + N I ++K L+ +L +EY + ++N E +
Sbjct: 2524 DMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPER 2583
Query: 683 ALMHTSNDLSRQLIAQEAQYKDL-WAEFQTTVKILVDNGEETLQDINNLTDKLRERDEKM 741
+ N L + + L +E ++ V + + + + + E+++K+
Sbjct: 2584 TNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKL 2643
Query: 742 QHVSTWLRGSLEGLRLLVEQESPMDL 767
+ L G+ + R ++ SP D+
Sbjct: 2644 LELQKLLEGNEKKQREKEKKRSPQDV 2669
Score = 57.4 bits (137), Expect = 5e-08
Identities = 123/647 (19%), Positives = 264/647 (40%), Gaps = 71/647 (10%)
Query: 178 VLSLNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQEL 237
VL++++ M K T + + +I++ D + Q +E E M +E L+R+ +
Sbjct: 1545 VLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQE----LVRQYQE 1600
Query: 238 TAQINEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESI 297
Q E +++ME +++++ ++LQ ++ ++ + +++ + NL + E
Sbjct: 1601 HQQATELLRQAHMRQME--RQREDQEQLQEEIKRLNRQLAQRSSI-DNENL----VSERE 1653
Query: 298 RYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLN---KIKQL-------- 346
R +E+ LK+ KLC N N+ + E K K+L
Sbjct: 1654 RVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVP 1713
Query: 347 VETLHAARMEYKDLREKM-KTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYF 405
E L R + ++ K L K + EE I D + K + S +
Sbjct: 1714 PEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQS--SASLIW 1771
Query: 406 LSQKRVDIKNM---EEGLITLQELQQATKT-VYQQQIKILSANLERE---SQRCVITQWK 458
S+ +K+ E +T + + + + + + I + S E SQR V + +
Sbjct: 1772 RSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFA 1831
Query: 459 MACLRKKHARWTAKIKAEIQAITEKI-----------QNAEVRRIELLNETSFRQQEISG 507
+ ++ I + +QA EK+ ++A+V + EL+ E+ ++QE +
Sbjct: 1832 GTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATE 1891
Query: 508 FVAQIEKLTTELKEEEKAFVNKEKMLMKELSK--------------YEEIFVKETQINKE 553
+ E+L L EE +A + L ELSK +E ++T I
Sbjct: 1892 SLKCQEELRERLHEESRA----REQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDR 1947
Query: 554 KEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISN 613
E+EL+ +LQ E E ++ + + E LS A + E + + ++ + +
Sbjct: 1948 LEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLL---QETEKLMKE 2004
Query: 614 MEDVKQELQQLRDQESKKNKDHFETLKNLENGFYINDQKADLLLLENKKLKEYILYLKNN 673
+V+ + +++RD K+ K ++ + F +Q+ + L++ ++ + +
Sbjct: 2005 KLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEK 2064
Query: 674 IEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTTVKILVDNGEETLQDINNLTDK 733
+ K+ + Q D+ +Q I + Q + FQ E +++ L +
Sbjct: 2065 MRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPI-------SEHQTREVEQLANH 2117
Query: 734 LRERDEKMQHVSTWLRGSLEGLRLLVEQESPMDLLSKQQLRALLVTS 780
L+E+ +K + ++ E+ ++ ++ +ALLV++
Sbjct: 2118 LKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSA 2164
Score = 55.1 bits (131), Expect = 3e-07
Identities = 122/660 (18%), Positives = 272/660 (41%), Gaps = 84/660 (12%)
Query: 98 ELNKLYYLLETLPNSIKRELEECVRDARRLNLFEINTIKMRITRTENEIELLKKKITDLT 157
E+ L+ + ++KRE +E + ++ L + I + ++ + E+ +K + T+L
Sbjct: 3093 EIQALHAQMNGRKITLKRE-QESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQ 3151
Query: 158 KYNEALGEKQEELARKHARFVLSLNQTMEKK-------ATTTVYINETYTKINLKREDIA 210
+ + EL + A+ L L T++ + + + + +++L + +A
Sbjct: 3152 EQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLA 3211
Query: 211 LQKKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVKRMETY-------QKKKELD 263
++K +E + +EKE+A+ ++ ++ + + + E ++ Q+K+ L+
Sbjct: 3212 SEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLN 3271
Query: 264 KLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFFTD 323
+ Q K+ + + NLE+ L ES + +E+S L A+L
Sbjct: 3272 ESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDG 3331
Query: 324 NKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLSEE----E 379
+ + ++ + L ++++ +E H+ +E + EK K + Q + + ++
Sbjct: 3332 TGQSRPPLPSE---DLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHR 3388
Query: 380 KAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIK 439
K +Q+ + E QK++ + K L Q++++ K + + L E Q+ + + Q +
Sbjct: 3389 KTLQTEQEANTEGQKKMHELQSKVEDL-QRQLEEKRQQVYKLDL-EGQRLQGIMQEFQKQ 3446
Query: 440 ILSANLERESQRCVI------TQWKMACLRKKHARWTAKIKAE----------------- 476
L +RES+R + T W + R ++ KI+ E
Sbjct: 3447 ELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGT 3506
Query: 477 ------------IQAITEKIQNAEVRRIELLN-ETS------FRQQEISGFVAQIEKLTT 517
+Q + K+Q + E L ET+ + Q+ I + Q++KLT
Sbjct: 3507 GCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTG 3566
Query: 518 ELKEEEKAFVNKE----KMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYK 573
+ + EE + V+ + + L + E+ +Q+ +EK +L + +L+ + Y+
Sbjct: 3567 Q-QGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEK-NDLRNMVMKLEEQIRWYR 3624
Query: 574 E--------KRRKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQQLR 625
+ R L +NI E+++ N + R + + +K EL+
Sbjct: 3625 QTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDS 3684
Query: 626 DQESKKNKDHFETLKNLENGFYINDQKADLLLLENKKLKEYILYLKNNIEKYREGQEALM 685
++ TLK + G Y+ + L+ KK Y+L L ++ + AL+
Sbjct: 3685 LLQTLSPDSEHVTLKRI-YGKYLRAESFRKALIYQKK---YLLLLLGGFQECEDATLALL 3740
Score = 53.5 bits (127), Expect = 8e-07
Identities = 130/619 (21%), Positives = 250/619 (40%), Gaps = 98/619 (15%)
Query: 21 AVSTGPSLELCTLPSTLGSSVAVEALEQLFVVEQSLQSDYFKCNEEAKIFLKDIAVAVKK 80
AVS S L TL S LG ++ ++ DY NE+ + L+D V+
Sbjct: 1194 AVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPE--LQDYRYEVQD 1251
Query: 81 LEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEECVRDARRLNL----FEINTIK 136
+E LL + E NKL L L ++ + + NL E +I
Sbjct: 1252 FQENMHT---LLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIH 1308
Query: 137 MRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFVLSLNQTMEKKATTTVYIN 196
++T E+ K K++ L + K EE ++ + SL Q +++
Sbjct: 1309 SQMTNLEDIDVNHKSKLSSLQDLEKT---KLEEQVQELESLISSLQQQLKE--------- 1356
Query: 197 ETYTKINLKREDIALQKKCIQEAEELM--------------EKERAEY---LIRKQ---- 235
T+ N + E LQK+ +E + + +R Y ++K
Sbjct: 1357 ---TEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGT 1413
Query: 236 -ELTAQINEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLH 294
E + + E T VK +E K+ ++L+ +++K V VS ++ E++R+
Sbjct: 1414 IEFSGEFGVKEETNIVKLLE----KQYQEQLEEEVAK----VIVSMSIAFAQQTELSRIS 1465
Query: 295 ESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDE--------KNEFLNKIKQL 346
++ + K+ A+ + + +F + K D I K EF K+L
Sbjct: 1466 GG----KENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKEL 1521
Query: 347 VETLHAARMEYKDLREKMKTLARQYKIVLSEE----EKAFLQKQKIHDENQKQLTFISQK 402
E + D + ++ + + +SEE +K F+ +Q IHDE + + +
Sbjct: 1522 GEHGKEILLSNSDPHDIPES--KDCVLTISEEMFSKDKTFIVRQSIHDEISVS-SMDASR 1578
Query: 403 EYFLSQKRVDIKNMEEGLI-TLQELQQATKTVYQQQIKILSANLERESQRCVITQWKMAC 461
+ L++++ +++M + L+ QE QQAT+ + Q ++ + E + Q
Sbjct: 1579 QLMLNEEQ--LEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQ----------- 1625
Query: 462 LRKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKE 521
L+++ R ++ A+ +I + +E R+ L + +Q ++G EKL EL+
Sbjct: 1626 LQEEIKRLNRQL-AQRSSIDNENLVSERERVLLEELEALKQLSLAG----REKLCCELRN 1680
Query: 522 EEKAFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEE 581
N + + EE KE +++++ E+ E L + A Q K R L+
Sbjct: 1681 SSTQTQNGN----ENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQ--KANNRLLKI 1734
Query: 582 LSNIITAQRQEEDLLNNHI 600
L ++ E+ + H+
Sbjct: 1735 LLEVVKTTAAVEETIGRHV 1753
Score = 50.4 bits (119), Expect = 7e-06
Identities = 78/336 (23%), Positives = 149/336 (44%), Gaps = 60/336 (17%)
Query: 504 EISG--FVAQIEKLTTELKEEEKAFVNKE------------KMLMKELS-KYEEIFVKET 548
E++G FV + K T L+EEE + +M+ EL+ K EI
Sbjct: 117 EVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEI----E 172
Query: 549 QINKEKEEELVEY----LPQLQVAEQEYKEKRRKLEEL-SNIITAQRQEEDLLNNHIFLF 603
++N+E EE V Y L QLQ E K++ + +L +N+ A+R++++ +
Sbjct: 173 ELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETM------- 225
Query: 604 TRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNL---ENGFYINDQ---KADLLL 657
R+F + ++ + QQL+ E+ +N H T +L + + Q + D LL
Sbjct: 226 -REFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLL 284
Query: 658 LENKKLKE----YILYLKNNIEKYREGQEALMHTSN------------DLSRQLIAQEAQ 701
+ +K KE I +L+ I+ Y Q+ + SN +L+ ++I +E +
Sbjct: 285 EDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKK 344
Query: 702 YKDLWAEFQTTVKILVDNGEETL---QDINNLTDKLRERDEKMQHVS---TWLRGSLEGL 755
+L + T K+L + E+ + Q+I N+ +L +K + S L G++E L
Sbjct: 345 TLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEEL 404
Query: 756 RLLVEQESPMDLLSKQQLRALLVTSKEEKTCQLSDL 791
+ ++S + Q++ E+ +L ++
Sbjct: 405 QKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEM 440
Score = 49.7 bits (117), Expect = 1e-05
Identities = 142/672 (21%), Positives = 271/672 (40%), Gaps = 115/672 (17%)
Query: 76 VAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEE----------CVRDAR 125
+ + + EE K T LE E EL LLE + +L+E ++D +
Sbjct: 728 IEILRQEEKEKGT---LEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEK 784
Query: 126 RLNLFEINTIKMRITRTENEIEL--LKKKITDLT--KYNEALGEKQEELARKHARFVLSL 181
+ L ++ I +++ E I L +K K D K E L E+ E+L ++ + L
Sbjct: 785 K-TLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQ----CIQL 839
Query: 182 NQTMEKKATTTVYINETYTKINLK--REDIALQKKCIQEAEELMEKERAEYLIRKQELTA 239
N+ +EK+ T + + + ++N + +E+ A K + E+ K+ EY + + L
Sbjct: 840 NEEIEKQRNTFSFAEKNF-EVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNE 898
Query: 240 QIN-EFENTREVKRM------------ETYQK----KKELDKLQTKMSKIKETVTVSAAV 282
+++ + N VK ET + +K+ +L K+ K +
Sbjct: 899 ELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQR 958
Query: 283 LSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNK 342
LSD + ++ + H I + +EV LK++ + + +L+ I N + E +
Sbjct: 959 LSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRC-------RELEIIINHNRAENVQS 1011
Query: 343 IKQLVETL------HAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQL 396
V +L +R + + K+ + KI++ E+K + + +E++++
Sbjct: 1012 CDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMV--EDKVSFENMTVGEESKQEQ 1069
Query: 397 TFISQ-----KEYFLS----------QKRVDIKNMEEGLITLQELQQ--ATKTVYQQQIK 439
+ KE L QK +++ E+ + LQ Q VY +
Sbjct: 1070 LILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVD 1129
Query: 440 ILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETS 499
+ +E E K C K+ I A EKI+ E+++I L +
Sbjct: 1130 QVREYMENEKD-------KALCSLKEEL---------IFAQEEKIK--ELQKIHQLELQT 1171
Query: 500 FRQQEISG----FVAQIEKLTTELKEEEKAFVNKEKMLMKELSKYEEIFVKETQINKEKE 555
+ QE I KL + EE F+ + L L +Y +K ++N E +
Sbjct: 1172 MKTQETGDEGKPLHLLIGKLQKAVSEECSYFL---QTLCSVLGEYYTPALK-CEVNAEDK 1227
Query: 556 EELVEYL-----PQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRY 610
E +Y+ P+LQ E ++ + + L N +T + N + L TR +
Sbjct: 1228 ENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEE------YNKLLVLQTRLSKIW 1281
Query: 611 ISNMEDVKQEL--QQLRDQESKKNKDHFETLKNLENGFYINDQK-ADLLLLENKKLKEYI 667
+ +K E + L +E++ H + + NLE+ + K + L LE KL+E +
Sbjct: 1282 GQQTDGMKLEFGEENLPKEETEFLSIHSQ-MTNLEDIDVNHKSKLSSLQDLEKTKLEEQV 1340
Query: 668 LYLKNNIEKYRE 679
L++ I ++
Sbjct: 1341 QELESLISSLQQ 1352
Score = 38.9 bits (89), Expect = 0.020
Identities = 102/518 (19%), Positives = 200/518 (38%), Gaps = 93/518 (17%)
Query: 62 KCNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEECV 121
+ E K L+D+ +++ ++ LLE + LN+ +E+ +L E
Sbjct: 3233 RSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSE-- 3290
Query: 122 RDARRLNL-FEINTIKMRITRTENEIELLKKKITDLTKYN------------EALGEKQE 168
R L L + + K+RI + ++ ++ L + + L E Q+
Sbjct: 3291 EQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQK 3350
Query: 169 ELARKHARFVLSLNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKERA 228
+L KH+R V LN+T + K ++ T+ +++ D + +K +Q +E
Sbjct: 3351 QLEEKHSRIVELLNETEKYK------LDSLQTRQQMEK-DRQVHRKTLQTEQE----ANT 3399
Query: 229 EYLIRKQELTAQINEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNL 288
E + EL +++ + + E KR + Y+ E +LQ M + ++ L
Sbjct: 3400 EGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQK-----------QEL 3448
Query: 289 EIARLHESIRYWEQEVSE-----LKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKI 343
E ES R Q ++E L D T N I + K K+
Sbjct: 3449 EREEKRESRRILYQNLNEPTTWSLTSDR----------TRNWVLQQKIEGETKESNYAKL 3498
Query: 344 KQLVETLHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKE 403
++ E + +R+K++ +A + + VL ++ LQ + DE+ FI +E
Sbjct: 3499 IEMNGGGTGCNHELEMIRQKLQCVASKLQ-VLPQKASERLQFETADDED-----FIWVQE 3552
Query: 404 YFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSANLERESQRCVITQWKMACLR 463
N++E ++ LQ+L + E V L
Sbjct: 3553 -----------NIDEIILQLQKL----------------TGQQGEEPSLVSPSTSCGSLT 3585
Query: 464 KKHARWTAKIKAEIQAITEK---IQNAEVR---RIELLNETSFRQQEISGFVAQIEKLTT 517
++ R A++ I +TE+ ++N ++ +I +T + S F
Sbjct: 3586 ERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIE 3645
Query: 518 ELKEEEKAFVNKEKM-LMKELSKYE-EIFVKETQINKE 553
+ EK N+EK+ L K L + E E++ + ++ +
Sbjct: 3646 AIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRND 3683
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 95.5 bits (236), Expect = 2e-19
Identities = 172/772 (22%), Positives = 325/772 (42%), Gaps = 119/772 (15%)
Query: 32 TLPSTLGSSVAVEALE---QLFVVEQSLQS------DYFKCNEEAKIFLKDIAVAVKKLE 82
TL ++ SS A + L+ Q+ +Q L+ DY K E D + + L+
Sbjct: 250 TLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKE-------DFTMQISFLQ 302
Query: 83 EMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEECVRDARRLNLFEINTIKMRITRT 142
E +++ ME +K + NS K E++E + + E+NT +I
Sbjct: 303 EK-------IKVYEMEQDK------KVENSNKEEIQE-----KETIIEELNT---KIIEE 341
Query: 143 ENEIELLKKKITDLTKYNEALGEKQEELARKHARFV---LSLNQTMEKKATTTVYINETY 199
E + LK K+T K LGE QE++ +K+ L L + +K+ ++ I +
Sbjct: 342 EKKTLELKDKLTTADKL---LGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLM 398
Query: 200 TKIN----------------LKREDIALQKKCIQEAEELMEKERAEYLIRKQELT----A 239
+ ++R + Q+K Q EL E + + KQEL A
Sbjct: 399 GTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMA 458
Query: 240 QINEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRY 299
Q+ E + + + + + + ++ + + L D N + +L E +
Sbjct: 459 QMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGL 518
Query: 300 WEQEVSELKKDLAILEAKLCFFTDNKEKL------DDISNDEKNEFLNKIKQLVETLHAA 353
+E L++ L L +L F + ++ + +E ++ L+ ++ L + +A
Sbjct: 519 ILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSA 578
Query: 354 RMEYKDLREKMKTLARQYKI---VLSEEEKAFLQKQKIHDENQ-----KQLTFISQKEYF 405
K+L K + YKI +L +E+ A L + E + QL F ++E
Sbjct: 579 SESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEE-- 636
Query: 406 LSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSANLERESQRCVITQWKMACLRKK 465
LS+ + D++ E I +++L+ Y+QQI L + SQ+ Q++ L K
Sbjct: 637 LSKLKEDLEI--EHRINIEKLKDNLGIHYKQQIDGLQNEM---SQKIETMQFEKDNLITK 691
Query: 466 HARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKA 525
+ +I ++++ + + + N++ + L +I+ +IE L E E+EK
Sbjct: 692 QNQLILEI-SKLKDLQQSLVNSKSEEMTL---------QINELQKEIEILRQE--EKEKG 739
Query: 526 FVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSNI 585
+ +E ++EL E+ K+ KEKE +L E QL+ K++++ LE++ I
Sbjct: 740 TLEQE---VQELQLKTELLEKQM---KEKENDLQEKFAQLEAENSILKDEKKTLEDMLKI 793
Query: 586 ITAQRQEEDLL-------NNHIFLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFET 638
T QEE L+ + ++ ++ I ED+KQ+ QL ++ K+
Sbjct: 794 HTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFA 853
Query: 639 LKNLENGFY-INDQKADLLLLENKKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIA 697
KN E + + ++ A LL K+K+ + KN E + + ++ L R
Sbjct: 854 EKNFEVNYQELQEEYACLL-----KVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPT 908
Query: 698 QEAQYKDLWAEFQTTVKILVDNGEETLQDINNLTDKL----RERDEKMQHVS 745
++ E +T V ++ GE +D L +KL RE+ E Q +S
Sbjct: 909 TVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLS 960
Score = 79.3 bits (194), Expect = 1e-14
Identities = 156/750 (20%), Positives = 306/750 (40%), Gaps = 118/750 (15%)
Query: 44 EALE-QLFVVEQSLQSDYFKCNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKL 102
+ALE QL + + L E +F ++I +KLE+ K I + ++
Sbjct: 2056 QALEKQLEKMRKFLDEQAIDREHERDVFQQEI----QKLEQQLKVVPRFQPISEHQTREV 2111
Query: 103 YYLLETLPNSIKRELEECVRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEA 162
E L N +K + ++C L ++ I EIE L+ ++ +L +
Sbjct: 2112 ----EQLANHLKEKTDKCSE-----LLLSKEQLQRDIQERNEEIEKLEFRVRELEQ--AL 2160
Query: 163 LGEKQEELARKHARFVLSLNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEEL 222
L E ++ A+ LSL ++ + I+ K ++I ++ +++ E
Sbjct: 2161 LVEDRKHFGAVEAKPELSLEVQLQAERDA----------IDRKEKEITNLEEQLEQFREE 2210
Query: 223 MEKERAEYLIRKQELTAQINEFENTREVKRMETYQK--KKELDKLQTKMSKIKETVTVSA 280
+E + E +++ + +I + E+T ++ +E K K +++KL IKE+ +S
Sbjct: 2211 LENKNEE--VQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLA---IKESDAMST 2265
Query: 281 AVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFL 340
D ++ + + I+ E E+ +L + + L+ +L TDNK +EKNE +
Sbjct: 2266 ---QDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVI------EEKNELI 2316
Query: 341 NKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFIS 400
+DL +++ L + V E+ Q ++ ++ Q++L I
Sbjct: 2317 -----------------RDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIG 2359
Query: 401 QKE----YFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSANLERESQRCVITQ 456
QK + LS++ +K+ + +I A K +QQ++ +AN E + V+ +
Sbjct: 2360 QKTSMNAHSLSEEADSLKHQLDVVI-------AEKLALEQQVE--TANEEMTFMKNVLKE 2410
Query: 457 WKMACLRKKHARWTAKIKAE----IQAITEKIQNAEVRRIE-----------------LL 495
+ ++ K + E IQ+I E N + + L
Sbjct: 2411 TNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLE 2470
Query: 496 NETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKML---------MKELSKYEEIFVK 546
N+T F+ E +G I L T L + E K+ L M+E ++E ++
Sbjct: 2471 NQTYFKSFEENG-KGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQ 2529
Query: 547 ETQINKEK---EEELVEYLPQLQV-AEQEYKEKRRKLEELS------NIITAQRQEEDLL 596
+ +N +K E+ + Q+Q+ A QEY + + + +S NI + ED L
Sbjct: 2530 KKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDEL 2589
Query: 597 NNHIFLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNL-ENGFYINDQKADL 655
+ I T S S + ++ L ++Q K+ E K L E + +
Sbjct: 2590 GSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQ 2649
Query: 656 LLLENKKLKEYILYLKNNIEKYREGQEA-LMHTSNDLSRQLIAQEAQ---YKDLWAEFQT 711
E K+ + + LK E + +E+ + L + +A +A+ YK+ + Q
Sbjct: 2650 REKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQE 2709
Query: 712 TVKILVDNGEETLQDINNLTDKLRERDEKM 741
+ + N +D++ + D L E EK+
Sbjct: 2710 ELLVKETNMTSLQKDLSQVRDHLAEAKEKL 2739
Score = 77.8 bits (190), Expect = 4e-14
Identities = 142/611 (23%), Positives = 263/611 (43%), Gaps = 113/611 (18%)
Query: 220 EELMEKERAEYLIRKQE-----LTAQINEFENTREVKRMETYQKKKELDKLQTKMSKIKE 274
E L + + E I++++ LTA + + ++ E + ++ KLQ + +++
Sbjct: 188 EGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQA 247
Query: 275 TVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFFT------DNKEKL 328
+ T+ + S ++ + + I +Q++ E L + K FT K K+
Sbjct: 248 SETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKV 307
Query: 329 DDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKI-----VLSEEEKAFL 383
++ D+K E NK + + + K + E+ KTL + K+ +L E ++ +
Sbjct: 308 YEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIV 367
Query: 384 QKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSA 443
QK + + +LT QKE Q +IK + + T++ELQ+ Q + I+
Sbjct: 368 QKNQEIKNMKLELTNSKQKE---RQSSEEIKQL---MGTVEELQKRNHKDSQFETDIVQ- 420
Query: 444 NLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQ 503
+E+E+QR K+ LR AE+ + +Q+
Sbjct: 421 RMEQETQR------KLEQLR-----------------------AELDEMYGQQIVQMKQE 451
Query: 504 EISGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLP 563
I +AQ+E++ T K E + L Y I V E QI + + +
Sbjct: 452 LIRQHMAQMEEMKTRHKGE----------MENALRSYSNITVNEDQI-----KLMNVAIN 496
Query: 564 QLQVAEQEYKEKRRKLEELSNII-----TAQRQEEDLLNNHIFLFTRDFSRYISNMEDVK 618
+L + Q+ ++ KL+E +I QRQ EDL+ FSR E ++
Sbjct: 497 ELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEE------LSFSR-----EQIQ 545
Query: 619 QELQQLRDQESKKNKDH--FETLKNLENGFY-INDQKADLLL-----LENKKLKEYILYL 670
+ Q + +QESK N+ H T+++L+ ++ + +L L + N K+K +L
Sbjct: 546 RARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEK 605
Query: 671 KNN--IEKYREGQEALMHTSNDLSRQLIAQEAQ-----YKDLWAEFQTTVKILVDN-GEE 722
+ N +++ E QEA + L QL+ + +DL E + ++ L DN G
Sbjct: 606 EKNAVLDRMAESQEAELER---LRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIH 662
Query: 723 TLQDINNLTDKLRERDEKMQHVSTWLRGSLEGLRLLVEQESPMDLLSK-QQLRALLVTSK 781
Q I+ L +++ ++ E MQ E L+ +Q + +SK + L+ LV SK
Sbjct: 663 YKQQIDGLQNEMSQKIETMQ---------FEKDNLITKQNQLILEISKLKDLQQSLVNSK 713
Query: 782 -EEKTCQLSDL 791
EE T Q+++L
Sbjct: 714 SEEMTLQINEL 724
Score = 73.2 bits (178), Expect = 9e-13
Identities = 137/669 (20%), Positives = 268/669 (40%), Gaps = 118/669 (17%)
Query: 81 LEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEECVRDARRLNLFEINTIKMRIT 140
LE +A D ++ + E+ L LE ++ + EE + +L + + + R+
Sbjct: 2179 LEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTT-RLQ 2237
Query: 141 RTENEIELLKKKITDLTKYNEALGEKQEELARKHARFVLSLNQTMEKKATTTVYINETYT 200
E E +L K D+ K A+ E + Q +++K +NE T
Sbjct: 2238 ELEQENKLFKD---DMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVT 2294
Query: 201 KINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVKRMETYQKKK 260
K+ + + I K I+E EL+ + ++ +++ E + + E Q +
Sbjct: 2295 KLQQQLK-ITTDNKVIEEKNELIRD-------LETQIECLMSDQECVKRNREEEIEQLNE 2346
Query: 261 ELDKLQTKMSKIKETVTVSAAVLSD------HNLEIARLHESIRYWEQEVSELKKDLAIL 314
++KLQ +++ I + +++A LS+ H L++ + E + EQ+V +++ +
Sbjct: 2347 VIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVV-IAEKLAL-EQQVETANEEMTFM 2404
Query: 315 E--AKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEY--KDLREKMKTLARQ 370
+ K F N+ + S + E + KI+ + E +++ KD E
Sbjct: 2405 KNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPE-------- 2456
Query: 371 YKIVLSEEEKAFLQKQ---KIHDENQKQL-----TFISQKEYFLSQKRVDIKNMEEGLIT 422
++VL+E+ L+ Q K +EN K T + Q E +S K +++ + +
Sbjct: 2457 LEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKD 2516
Query: 423 LQELQQATKTVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAITE 482
+QE Q + Q++I L +E + +++Q ++ +++ AK + Q I+
Sbjct: 2517 MQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEY-----AKFCQDNQTIS- 2570
Query: 483 KIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSKYEE 542
+E R + N R+ E+ + I LT + E E V
Sbjct: 2571 ----SEPERTNIQNLNQLREDELG---SDISALTLRISELESQVVEMH------------ 2611
Query: 543 IFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHIFL 602
T + EKE Q+++AE+ EK +KL EL ++ +++
Sbjct: 2612 -----TSLILEKE--------QVEIAEKNVLEKEKKLLELQKLLEGNEKKQ--------- 2649
Query: 603 FTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNLENGFYINDQ-----KADLLL 657
R++E K++ E LK F+ N++ + + L
Sbjct: 2650 ----------------------REKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALR 2687
Query: 658 LENKKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTTVKILV 717
E+ K + K EK +E E L+ +N S Q +Q +D AE + + IL
Sbjct: 2688 AESVATKAELASYKEKAEKLQE--ELLVKETNMTSLQ--KDLSQVRDHLAEAKEKLSILE 2743
Query: 718 DNGEETLQD 726
E +Q+
Sbjct: 2744 KEDETEVQE 2752
Score = 59.3 bits (142), Expect = 1e-08
Identities = 126/578 (21%), Positives = 233/578 (40%), Gaps = 75/578 (12%)
Query: 44 EALEQLFVVEQSLQSDYFKCNEEAKIFLKDIAVAVKKLEE--------MRKATIDLLEIE 95
E LEQ ++ + + + + +I K+ +++LE+ M K + + E +
Sbjct: 2202 EQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESD 2261
Query: 96 SMELNKLYYLLETLPNSIKR---ELEECVRDARRLNLFEINTIKMRITRTENEIELLKKK 152
+M + L I+ E+++ +L +++IT IE +
Sbjct: 2262 AMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQ------QLKITTDNKVIEEKNEL 2315
Query: 153 ITDLTKYNEALGEKQEELARKHARFVLSLNQTMEKKATTTVYINETYTKINLKREDIALQ 212
I DL E L QE + R + LN+ +EK I + K ++ ++
Sbjct: 2316 IRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQ---KTSMNAHSLS-- 2370
Query: 213 KKCIQEAEEL---MEKERAEYLIRKQELTAQINEFENTREVKRMETYQKKKELDKLQTKM 269
+EA+ L ++ AE L +Q++ E + V + ET K +L + +
Sbjct: 2371 ----EEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLK-ETNFKMNQLTQELFSL 2425
Query: 270 SKIKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLD 329
+ +E+V ++ ++++ +A H S E EV + L LE + F + +
Sbjct: 2426 KRERESVEKIQSI-PENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKG 2484
Query: 330 DISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIH 389
I N E ++ QL T+ A +E +++K + Q + +K + QKI
Sbjct: 2485 SIINLE-----TRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIV 2539
Query: 390 DE-------NQKQLTFISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILS 442
+E +Q QL + + F + E +Q L Q + I L+
Sbjct: 2540 EEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPER--TNIQNLNQLREDELGSDISALT 2597
Query: 443 ANL-ERESQ-----RCVITQWKMACLRKKHARWTAKIKAEIQAITE----KIQNAEVRR- 491
+ E ESQ +I + + + +K+ K E+Q + E K + E +R
Sbjct: 2598 LRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRS 2657
Query: 492 ---IELLNETS--FRQQEISGFVAQIEKLTTE---LKEEEKAFVNKEKMLMKELSKYEEI 543
+E+L T+ F E SGF ++E L E K E ++ K + L EE+
Sbjct: 2658 PQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQ------EEL 2711
Query: 544 FVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEE 581
VKET + +++ L Q++ E KEK LE+
Sbjct: 2712 LVKETNMTSLQKD-----LSQVRDHLAEAKEKLSILEK 2744
Score = 57.4 bits (137), Expect = 5e-08
Identities = 123/649 (18%), Positives = 264/649 (40%), Gaps = 71/649 (10%)
Query: 178 VLSLNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQEL 237
VL++++ M K T + + +I++ D + Q +E E M +E L+R+ +
Sbjct: 1545 VLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQE----LVRQYQE 1600
Query: 238 TAQINEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESI 297
Q E +++ME +++++ ++LQ ++ ++ + +++ + NL + E
Sbjct: 1601 HQQATELLRQAHMRQME--RQREDQEQLQEEIKRLNRQLAQRSSI-DNENL----VSERE 1653
Query: 298 RYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLN---KIKQL-------- 346
R +E+ LK+ KLC N N+ + E K K+L
Sbjct: 1654 RVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVP 1713
Query: 347 VETLHAARMEYKDLREKM-KTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYF 405
E L R + ++ K L K + EE I D + K + S +
Sbjct: 1714 PEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQS--SASLIW 1771
Query: 406 LSQKRVDIKNM---EEGLITLQELQQATKT-VYQQQIKILSANLERE---SQRCVITQWK 458
S+ +K+ E +T + + + + + + I + S E SQR V + +
Sbjct: 1772 RSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFA 1831
Query: 459 MACLRKKHARWTAKIKAEIQAITEKI-----------QNAEVRRIELLNETSFRQQEISG 507
+ ++ I + +QA EK+ ++A+V + EL+ E+ ++QE +
Sbjct: 1832 GTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATE 1891
Query: 508 FVAQIEKLTTELKEEEKAFVNKEKMLMKELSK--------------YEEIFVKETQINKE 553
+ E+L L EE +A + L ELSK +E ++T I
Sbjct: 1892 SLKCQEELRERLHEESRA----REQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDR 1947
Query: 554 KEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISN 613
E+EL+ +LQ E E ++ + + E LS A + E + + ++ + +
Sbjct: 1948 LEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLL---QETEKLMKE 2004
Query: 614 MEDVKQELQQLRDQESKKNKDHFETLKNLENGFYINDQKADLLLLENKKLKEYILYLKNN 673
+V+ + +++RD K+ K ++ + F +Q+ + L++ ++ + +
Sbjct: 2005 KLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEK 2064
Query: 674 IEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTTVKILVDNGEETLQDINNLTDK 733
+ K+ + Q D+ +Q I + Q + FQ E +++ L +
Sbjct: 2065 MRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPI-------SEHQTREVEQLANH 2117
Query: 734 LRERDEKMQHVSTWLRGSLEGLRLLVEQESPMDLLSKQQLRALLVTSKE 782
L+E+ +K + ++ E+ ++ ++ +ALLV ++
Sbjct: 2118 LKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRK 2166
Score = 55.1 bits (131), Expect = 3e-07
Identities = 122/660 (18%), Positives = 272/660 (41%), Gaps = 84/660 (12%)
Query: 98 ELNKLYYLLETLPNSIKRELEECVRDARRLNLFEINTIKMRITRTENEIELLKKKITDLT 157
E+ L+ + ++KRE +E + ++ L + I + ++ + E+ +K + T+L
Sbjct: 3085 EIQALHAQMNGRKITLKRE-QESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQ 3143
Query: 158 KYNEALGEKQEELARKHARFVLSLNQTMEKK-------ATTTVYINETYTKINLKREDIA 210
+ + EL + A+ L L T++ + + + + +++L + +A
Sbjct: 3144 EQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLA 3203
Query: 211 LQKKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVKRMETY-------QKKKELD 263
++K +E + +EKE+A+ ++ ++ + + + E ++ Q+K+ L+
Sbjct: 3204 SEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLN 3263
Query: 264 KLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFFTD 323
+ Q K+ + + NLE+ L ES + +E+S L A+L
Sbjct: 3264 ESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDG 3323
Query: 324 NKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLSEE----E 379
+ + ++ + L ++++ +E H+ +E + EK K + Q + + ++
Sbjct: 3324 TGQSRPPLPSE---DLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHR 3380
Query: 380 KAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIK 439
K +Q+ + E QK++ + K L Q++++ K + + L E Q+ + + Q +
Sbjct: 3381 KTLQTEQEANTEGQKKMHELQSKVEDL-QRQLEEKRQQVYKLDL-EGQRLQGIMQEFQKQ 3438
Query: 440 ILSANLERESQRCVI------TQWKMACLRKKHARWTAKIKAE----------------- 476
L +RES+R + T W + R ++ KI+ E
Sbjct: 3439 ELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGT 3498
Query: 477 ------------IQAITEKIQNAEVRRIELLN-ETS------FRQQEISGFVAQIEKLTT 517
+Q + K+Q + E L ET+ + Q+ I + Q++KLT
Sbjct: 3499 GCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTG 3558
Query: 518 ELKEEEKAFVNKE----KMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYK 573
+ + EE + V+ + + L + E+ +Q+ +EK +L + +L+ + Y+
Sbjct: 3559 Q-QGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEK-NDLRNMVMKLEEQIRWYR 3616
Query: 574 E--------KRRKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQQLR 625
+ R L +NI E+++ N + R + + +K EL+
Sbjct: 3617 QTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDS 3676
Query: 626 DQESKKNKDHFETLKNLENGFYINDQKADLLLLENKKLKEYILYLKNNIEKYREGQEALM 685
++ TLK + G Y+ + L+ KK Y+L L ++ + AL+
Sbjct: 3677 LLQTLSPDSEHVTLKRI-YGKYLRAESFRKALIYQKK---YLLLLLGGFQECEDATLALL 3732
Score = 53.5 bits (127), Expect = 8e-07
Identities = 130/619 (21%), Positives = 250/619 (40%), Gaps = 98/619 (15%)
Query: 21 AVSTGPSLELCTLPSTLGSSVAVEALEQLFVVEQSLQSDYFKCNEEAKIFLKDIAVAVKK 80
AVS S L TL S LG ++ ++ DY NE+ + L+D V+
Sbjct: 1194 AVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPE--LQDYRYEVQD 1251
Query: 81 LEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEECVRDARRLNL----FEINTIK 136
+E LL + E NKL L L ++ + + NL E +I
Sbjct: 1252 FQENMHT---LLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIH 1308
Query: 137 MRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFVLSLNQTMEKKATTTVYIN 196
++T E+ K K++ L + K EE ++ + SL Q +++
Sbjct: 1309 SQMTNLEDIDVNHKSKLSSLQDLEKT---KLEEQVQELESLISSLQQQLKE--------- 1356
Query: 197 ETYTKINLKREDIALQKKCIQEAEELM--------------EKERAEY---LIRKQ---- 235
T+ N + E LQK+ +E + + +R Y ++K
Sbjct: 1357 ---TEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGT 1413
Query: 236 -ELTAQINEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLH 294
E + + E T VK +E K+ ++L+ +++K V VS ++ E++R+
Sbjct: 1414 IEFSGEFGVKEETNIVKLLE----KQYQEQLEEEVAK----VIVSMSIAFAQQTELSRIS 1465
Query: 295 ESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDE--------KNEFLNKIKQL 346
++ + K+ A+ + + +F + K D I K EF K+L
Sbjct: 1466 GG----KENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKEL 1521
Query: 347 VETLHAARMEYKDLREKMKTLARQYKIVLSEE----EKAFLQKQKIHDENQKQLTFISQK 402
E + D + ++ + + +SEE +K F+ +Q IHDE + + +
Sbjct: 1522 GEHGKEILLSNSDPHDIPES--KDCVLTISEEMFSKDKTFIVRQSIHDEISVS-SMDASR 1578
Query: 403 EYFLSQKRVDIKNMEEGLI-TLQELQQATKTVYQQQIKILSANLERESQRCVITQWKMAC 461
+ L++++ +++M + L+ QE QQAT+ + Q ++ + E + Q
Sbjct: 1579 QLMLNEEQ--LEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQ----------- 1625
Query: 462 LRKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKE 521
L+++ R ++ A+ +I + +E R+ L + +Q ++G EKL EL+
Sbjct: 1626 LQEEIKRLNRQL-AQRSSIDNENLVSERERVLLEELEALKQLSLAG----REKLCCELRN 1680
Query: 522 EEKAFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEE 581
N + + EE KE +++++ E+ E L + A Q K R L+
Sbjct: 1681 SSTQTQNGN----ENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQ--KANNRLLKI 1734
Query: 582 LSNIITAQRQEEDLLNNHI 600
L ++ E+ + H+
Sbjct: 1735 LLEVVKTTAAVEETIGRHV 1753
Score = 50.4 bits (119), Expect = 7e-06
Identities = 78/336 (23%), Positives = 149/336 (44%), Gaps = 60/336 (17%)
Query: 504 EISG--FVAQIEKLTTELKEEEKAFVNKE------------KMLMKELS-KYEEIFVKET 548
E++G FV + K T L+EEE + +M+ EL+ K EI
Sbjct: 117 EVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEI----E 172
Query: 549 QINKEKEEELVEY----LPQLQVAEQEYKEKRRKLEEL-SNIITAQRQEEDLLNNHIFLF 603
++N+E EE V Y L QLQ E K++ + +L +N+ A+R++++ +
Sbjct: 173 ELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETM------- 225
Query: 604 TRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNL---ENGFYINDQ---KADLLL 657
R+F + ++ + QQL+ E+ +N H T +L + + Q + D LL
Sbjct: 226 -REFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLL 284
Query: 658 LENKKLKE----YILYLKNNIEKYREGQEALMHTSN------------DLSRQLIAQEAQ 701
+ +K KE I +L+ I+ Y Q+ + SN +L+ ++I +E +
Sbjct: 285 EDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKK 344
Query: 702 YKDLWAEFQTTVKILVDNGEETL---QDINNLTDKLRERDEKMQHVS---TWLRGSLEGL 755
+L + T K+L + E+ + Q+I N+ +L +K + S L G++E L
Sbjct: 345 TLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEEL 404
Query: 756 RLLVEQESPMDLLSKQQLRALLVTSKEEKTCQLSDL 791
+ ++S + Q++ E+ +L ++
Sbjct: 405 QKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEM 440
Score = 49.7 bits (117), Expect = 1e-05
Identities = 142/672 (21%), Positives = 271/672 (40%), Gaps = 115/672 (17%)
Query: 76 VAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEE----------CVRDAR 125
+ + + EE K T LE E EL LLE + +L+E ++D +
Sbjct: 728 IEILRQEEKEKGT---LEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEK 784
Query: 126 RLNLFEINTIKMRITRTENEIEL--LKKKITDLT--KYNEALGEKQEELARKHARFVLSL 181
+ L ++ I +++ E I L +K K D K E L E+ E+L ++ + L
Sbjct: 785 K-TLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQ----CIQL 839
Query: 182 NQTMEKKATTTVYINETYTKINLK--REDIALQKKCIQEAEELMEKERAEYLIRKQELTA 239
N+ +EK+ T + + + ++N + +E+ A K + E+ K+ EY + + L
Sbjct: 840 NEEIEKQRNTFSFAEKNF-EVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNE 898
Query: 240 QIN-EFENTREVKRM------------ETYQK----KKELDKLQTKMSKIKETVTVSAAV 282
+++ + N VK ET + +K+ +L K+ K +
Sbjct: 899 ELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQR 958
Query: 283 LSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNK 342
LSD + ++ + H I + +EV LK++ + + +L+ I N + E +
Sbjct: 959 LSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRC-------RELEIIINHNRAENVQS 1011
Query: 343 IKQLVETL------HAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQL 396
V +L +R + + K+ + KI++ E+K + + +E++++
Sbjct: 1012 CDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMV--EDKVSFENMTVGEESKQEQ 1069
Query: 397 TFISQ-----KEYFLS----------QKRVDIKNMEEGLITLQELQQ--ATKTVYQQQIK 439
+ KE L QK +++ E+ + LQ Q VY +
Sbjct: 1070 LILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVD 1129
Query: 440 ILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETS 499
+ +E E K C K+ I A EKI+ E+++I L +
Sbjct: 1130 QVREYMENEKD-------KALCSLKEEL---------IFAQEEKIK--ELQKIHQLELQT 1171
Query: 500 FRQQEISG----FVAQIEKLTTELKEEEKAFVNKEKMLMKELSKYEEIFVKETQINKEKE 555
+ QE I KL + EE F+ + L L +Y +K ++N E +
Sbjct: 1172 MKTQETGDEGKPLHLLIGKLQKAVSEECSYFL---QTLCSVLGEYYTPALK-CEVNAEDK 1227
Query: 556 EELVEYL-----PQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRY 610
E +Y+ P+LQ E ++ + + L N +T + N + L TR +
Sbjct: 1228 ENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEE------YNKLLVLQTRLSKIW 1281
Query: 611 ISNMEDVKQEL--QQLRDQESKKNKDHFETLKNLENGFYINDQK-ADLLLLENKKLKEYI 667
+ +K E + L +E++ H + + NLE+ + K + L LE KL+E +
Sbjct: 1282 GQQTDGMKLEFGEENLPKEETEFLSIHSQ-MTNLEDIDVNHKSKLSSLQDLEKTKLEEQV 1340
Query: 668 LYLKNNIEKYRE 679
L++ I ++
Sbjct: 1341 QELESLISSLQQ 1352
Score = 38.9 bits (89), Expect = 0.020
Identities = 102/518 (19%), Positives = 200/518 (38%), Gaps = 93/518 (17%)
Query: 62 KCNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEECV 121
+ E K L+D+ +++ ++ LLE + LN+ +E+ +L E
Sbjct: 3225 RSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSE-- 3282
Query: 122 RDARRLNL-FEINTIKMRITRTENEIELLKKKITDLTKYN------------EALGEKQE 168
R L L + + K+RI + ++ ++ L + + L E Q+
Sbjct: 3283 EQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQK 3342
Query: 169 ELARKHARFVLSLNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKERA 228
+L KH+R V LN+T + K ++ T+ +++ D + +K +Q +E
Sbjct: 3343 QLEEKHSRIVELLNETEKYK------LDSLQTRQQMEK-DRQVHRKTLQTEQE----ANT 3391
Query: 229 EYLIRKQELTAQINEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNL 288
E + EL +++ + + E KR + Y+ E +LQ M + ++ L
Sbjct: 3392 EGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQK-----------QEL 3440
Query: 289 EIARLHESIRYWEQEVSE-----LKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKI 343
E ES R Q ++E L D T N I + K K+
Sbjct: 3441 EREEKRESRRILYQNLNEPTTWSLTSDR----------TRNWVLQQKIEGETKESNYAKL 3490
Query: 344 KQLVETLHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKE 403
++ E + +R+K++ +A + + VL ++ LQ + DE+ FI +E
Sbjct: 3491 IEMNGGGTGCNHELEMIRQKLQCVASKLQ-VLPQKASERLQFETADDED-----FIWVQE 3544
Query: 404 YFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSANLERESQRCVITQWKMACLR 463
N++E ++ LQ+L + E V L
Sbjct: 3545 -----------NIDEIILQLQKL----------------TGQQGEEPSLVSPSTSCGSLT 3577
Query: 464 KKHARWTAKIKAEIQAITEK---IQNAEVR---RIELLNETSFRQQEISGFVAQIEKLTT 517
++ R A++ I +TE+ ++N ++ +I +T + S F
Sbjct: 3578 ERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIE 3637
Query: 518 ELKEEEKAFVNKEKM-LMKELSKYE-EIFVKETQINKE 553
+ EK N+EK+ L K L + E E++ + ++ +
Sbjct: 3638 AIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRND 3675
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 95.1 bits (235), Expect = 2e-19
Identities = 175/811 (21%), Positives = 336/811 (41%), Gaps = 97/811 (11%)
Query: 40 SVAVEALEQLFVVE-QSLQSDYFKCNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIESME 98
S VE LE V E QSLQ+ C +K +K+ A K +E +R+ + ++I E
Sbjct: 504 SKKVEILENEIVQEKQSLQN----CQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQE 559
Query: 99 LNKLYYLLETLPNSIKRELEECVRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTK 158
L + +L + E V+D + N +IK ++ ++IE K++I +
Sbjct: 560 NEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKL-SKIEFEKRQIKKELE 618
Query: 159 YNEALGEKQEELARKHARFVLSLNQTMEKKATTTVYINETYTKIN-----LKREDIALQK 213
+ + GE+ EEL + + N+ ++KK T E + L+RE+ L+K
Sbjct: 619 HYKEKGERAEELENE-LHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKK 677
Query: 214 -----KCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVKRMETYQKKKELDKLQTK 268
K + E +EKE ++ EL + + +K + + KEL+ + +
Sbjct: 678 TLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLK-CASMKMAQLQLENKELESEKEQ 736
Query: 269 MSKIKETVTVS-------AAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFF 321
+ K E + S ++E RL +++ +++ +L+ +L LE +
Sbjct: 737 LKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTL 796
Query: 322 TDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKIV------- 374
N E+L IS+ + + K L + + K L ++ K L +Q +I
Sbjct: 797 QKNLEELK-ISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEEN 855
Query: 375 ------LSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKR-VDIKNMEEGLITLQELQ 427
L +E K ++ I+ E+ +L + ++ L ++ +DIK L+TL+E
Sbjct: 856 NVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKT----LVTLREDL 911
Query: 428 QATKTVYQQ----------QIKILSANLER--ESQRCVITQWKMACLRKKHARWTAKIKA 475
+ K QQ +++ + N ER ++ ++K+ ++ + +K
Sbjct: 912 VSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLL-----ESKLESTLKK 966
Query: 476 EIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLMK 535
++ EKI E R E N +QE+ E L + +++E+ V +
Sbjct: 967 SLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEAL--KQRQDEERMVQSSPPISG 1024
Query: 536 ELSKYEEIFVKETQINKEKEEELVEYLPQ---LQVAEQEYKEKRRKLEELSN-----IIT 587
E +K+E + T+ + ++ L+E LQ +Q K + ++LE +N I+
Sbjct: 1025 EDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILA 1084
Query: 588 AQRQEEDLLNNHIFLFTRDFSRYISNM-------EDVKQELQQLRDQESKKNKDHF---- 636
QRQ L + L T++ + N + Q Q L Q S +N++
Sbjct: 1085 LQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKE 1144
Query: 637 -ETLKNLENGFYINDQKADLLLLENKKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQL 695
E LK+L + + +K +LL E ++ ++ + E D QL
Sbjct: 1145 REDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQL 1204
Query: 696 IAQEAQYKDLWAEFQT-TVKILVDNGEETLQDINNLTDKLRERDEKMQHVSTWLRGSLEG 754
+ Q+ Q +DL + K+L++N + + + KL ++++ H + L E
Sbjct: 1205 LKQKGQLEDLEKMLKVEQEKMLLEN--KNHETVAAEYKKLCGENDRLNHTYSQLLKETEV 1262
Query: 755 LRLLVEQESPMDLLSKQQLRALLVTSKEEKT 785
L+ + L++LL SK E+T
Sbjct: 1263 LQ-----------TDHKNLKSLLNNSKLEQT 1282
Score = 82.0 bits (201), Expect = 2e-15
Identities = 136/640 (21%), Positives = 276/640 (43%), Gaps = 95/640 (14%)
Query: 186 EKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQINEFE 245
E + +V + + KI R+++ + + + + ++ +E+ E +QE +++
Sbjct: 244 ESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDAR 303
Query: 246 NTREVK-RMETYQKKK-ELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWEQE 303
+ R + ++ ++K +DKL++++S+ KE RLH+ I +++
Sbjct: 304 SARMYRDELDALREKAVRVDKLESEVSRYKE-----------------RLHD-IEFYKAR 345
Query: 304 VSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARME------- 356
V ELK+D +L D E S D+ +E + QL LH ME
Sbjct: 346 VEELKEDNQVLLETKTMLEDQLEGTRARS-DKLHELEKENLQLKAKLHDMEMERDMDRKK 404
Query: 357 YKDLREKMKTLARQYKIVLSE------EEKAFLQKQKIHDENQKQLTFISQKEYFLSQKR 410
++L E+ TL K + E E + + ++ + QK L + S +
Sbjct: 405 IEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGH--EVNELTSSRL 462
Query: 411 VDIKNMEEGLI-TLQELQQATKTVYQQQIKILSANLERESQRCV---------ITQWKMA 460
+ ++ + L T++EL+ +V KIL +E+E+QR I Q K +
Sbjct: 463 LKLEMENQSLTKTVEELRTTVDSVEGNASKILK--MEKENQRLSKKVEILENEIVQEKQS 520
Query: 461 CLRKKH-ARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTEL 519
++ ++ K KA+++ E ++ R+I++L + + + + Q +++ E
Sbjct: 521 LQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEA 580
Query: 520 KEEEKAFVNK--EKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRR 577
+ ++ NK + + + SK +I ++ QI KE E YKEK
Sbjct: 581 RVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEH---------------YKEKGE 625
Query: 578 KLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFE 637
+ EEL N + +E +LL I + +E ++QE +L ++E++K K +
Sbjct: 626 RAEELENELHHLEKENELLQKKI----TNLKITCEKIEALEQENSEL-ERENRKLKKTLD 680
Query: 638 TLKNLENGFYINDQKADLLLLENKKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIA 697
+ KNL + + L EN +L E L L+ N+E + + + +++L +
Sbjct: 681 SFKNL-------TFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLE-NKELES 732
Query: 698 QEAQYKD----LWAEFQTTVKILV---------DNGEETLQDINNLTDKLRERDEKMQHV 744
++ Q K L A F+ T ++ V ++TL++ N +L + ++
Sbjct: 733 EKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEME 792
Query: 745 STWLRGSLEGLRLLVEQESPMDLLSKQQLRALLVTSKEEK 784
+ L+ +LE L++ ++ L K+ TS+ EK
Sbjct: 793 NQTLQKNLEELKI---SSKRLEQLEKENKSLEQETSQLEK 829
Score = 74.7 bits (182), Expect = 3e-13
Identities = 165/766 (21%), Positives = 322/766 (42%), Gaps = 119/766 (15%)
Query: 43 VEALEQLFVVEQSLQSDYFKCNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKL 102
++AL + V L+S+ + E L DI ++EE+++ LLE ++M ++L
Sbjct: 312 LDALREKAVRVDKLESEVSRYKER----LHDIEFYKARVEELKEDNQVLLETKTMLEDQL 367
Query: 103 YYLLETLPNSIKRELEECVRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEA 162
E R AR L E+ E E LK K+ D+ +
Sbjct: 368 ----------------EGTR-ARSDKLHEL----------EKENLQLKAKLHDMEMERDM 400
Query: 163 LGEKQEELARKHARFVLSLNQTMEKKATTTVYINETYTKINLKRE-DIALQKKCIQEAEE 221
+K EEL ++ ++ Q+M++ ++++ +I+ E A QK E E
Sbjct: 401 DRKKIEELMEENMTLEMAQKQSMDE----SLHLGWELEQISRTSELSEAPQKSLGHEVNE 456
Query: 222 LMEKERAEYLIRKQELTAQINEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAA 281
L + + Q LT + E T V +E K KM K + ++
Sbjct: 457 LTSSRLLKLEMENQSLTKTVEELRTT--VDSVEGNASK------ILKMEKENQRLSKKVE 508
Query: 282 VLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKE---KLDDISNDEKNE 338
+L + EI + +S++ + +L K+ A LE + +N E K+ + N+ N+
Sbjct: 509 ILEN---EIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQ 565
Query: 339 FLNKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTF 398
++ ++Q + AR+ KD+ ++ K L K S+ K +K++I +K+L
Sbjct: 566 TVSSLRQRSQISAEARV--KDIEKENKILHESIKETSSKLSKIEFEKRQI----KKELEH 619
Query: 399 ISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQ--QQIKILSANLERESQRCVIT- 455
+K + ++ ++E+ LQ+ K + + ++ ++ LERE+++ T
Sbjct: 620 YKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTL 679
Query: 456 ------QWKMACLRKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFV 509
+++ L K++++ + E++ E ++ A ++ +L E + E
Sbjct: 680 DSFKNLTFQLESLEKENSQLDEE-NLELRRNVESLKCASMKMAQLQLENKELESEKEQLK 738
Query: 510 AQIEKLTTELKEEEKAFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAE 569
+E L K+ E+ V+ + + E +++T N K+ + +E +LQ E
Sbjct: 739 KGLELLKASFKKTERLEVSYQGL------DIENQRLQKTLENSNKKIQQLE--SELQDLE 790
Query: 570 QEYKEKRRKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQQLRDQES 629
E + ++ LEEL I+++R E+ + ++E +L++ + Q
Sbjct: 791 MENQTLQKNLEELK--ISSKRLEQ-------------LEKENKSLEQETSQLEKDKKQLE 835
Query: 630 KKNKDHFETLKNLENGFYINDQKADLLLLENKKLKEYILYLKNNIEKYREGQEALMHTSN 689
K+NK + + + N+ K L ENK L + I K + + +E ++
Sbjct: 836 KENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKE------ 889
Query: 690 DLSRQLIAQEAQYKDLWAEFQTTVKILVDNGEETL--QDINNLTDKLRERDEKMQHVSTW 747
+++L+ K + +T V + D E L Q +NN +KL EK+
Sbjct: 890 --NKELV------KRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKI------ 935
Query: 748 LRGSLEGLRLLVEQESPMD--LLSKQQLRALLVTS---KEEKTCQL 788
L RLL +++S D L + +L + L S KEEK L
Sbjct: 936 ---GLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAAL 978
Score = 63.9 bits (154), Expect = 6e-10
Identities = 100/531 (18%), Positives = 223/531 (41%), Gaps = 63/531 (11%)
Query: 65 EEAKIFLKDIAVAVKKLEEMRKATI-DLLEIESM--ELNKLYYLLETLPNSIKRELEECV 121
+E K +K + +K L +R+ + + L+ + M +L KL + LE + + +R L +
Sbjct: 888 KENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQ 947
Query: 122 RDARRLNLFEI---NTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFV 178
R L E +T+K + E +I L+ ++ + T YN+ L ++ + + + +
Sbjct: 948 STDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYE--A 1005
Query: 179 LSLNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKER--AEYLIRKQE 236
L Q E+ ++ I+ K +RE ++ ++ + L+E ER A KQ
Sbjct: 1006 LKQRQDEERMVQSSPPISGEDNK--WERESQETTRELLKVKDRLIEVERNNATLQAEKQA 1063
Query: 237 LTAQINEFENTRE-------VKRMETYQKKKELDKLQTKMSKIK---ETVTVSAAVLSDH 286
L Q+ + E + +T +++ LQT+ +K++ T+ + L +
Sbjct: 1064 LKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQ 1123
Query: 287 NLEIARLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQL 346
N ++ S+ + V + ++DL L L + E L + E ++K L
Sbjct: 1124 NAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTL 1183
Query: 347 VETLHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFL 406
+E++DL ++ L +Q + E+ ++++K+ EN+ T ++ +
Sbjct: 1184 KSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLC 1243
Query: 407 SQKRVDIKNMEEGLITLQELQQATKTVY--QQQIKILSANLERESQRCVITQWKMACLRK 464
+ D N T +L + T+ + + +K L N + E R
Sbjct: 1244 GEN--DRLNH-----TYSQLLKETEVLQTDHKNLKSLLNNSKLEQTR------------- 1283
Query: 465 KHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEK 524
++AE + E+ Q ++ +L N+ + +L L+EE +
Sbjct: 1284 --------LEAEFSKLKEQYQQLDITSTKLNNQCEL-----------LSQLKGNLEEENR 1324
Query: 525 AFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEK 575
+++ + LM + E ++ + ++ + ++ L +L+ +++ +EK
Sbjct: 1325 HLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEK 1375
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 94.7 bits (234), Expect = 3e-19
Identities = 160/816 (19%), Positives = 344/816 (42%), Gaps = 99/816 (12%)
Query: 25 GPSLELCTLPSTLGSSVAVEALEQLFVVEQSLQSDYFKCNEEAKIFLKDIAVAVKKLEEM 84
G S +L + L + +A E QL E+ LQ+ + EEA +A+KK+ E+
Sbjct: 1055 GDSTDLSDQIAELQAQIA-ELKMQLAKKEEELQAALARVEEEAA----QKNMALKKIREL 1109
Query: 85 RKATIDL---LEIESMELNKLYYLLETLPN---SIKRELEECVRDARRLNLFEINTIKMR 138
+L LE E NK L ++K ELE+ +
Sbjct: 1110 ESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELR------- 1162
Query: 139 ITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFVLSLNQTMEKKATTTVYINET 198
++ E E+ +LKK + + K +EA + +E+ +KH++ V L + +E+ + +
Sbjct: 1163 -SKREQEVNILKKTLEEEAKTHEA---QIQEMRQKHSQAVEELAEQLEQTKRVKANLEKA 1218
Query: 199 YTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVKRMETYQK 258
+ +R ++A + K + + + E +R + + QEL + NE E R +
Sbjct: 1219 KQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRT-------EL 1271
Query: 259 KKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKL 318
++ KLQ ++ + ++ S + S + + L ++ ++ + E + L KL
Sbjct: 1272 ADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKL 1331
Query: 319 CFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMK------TLARQYK 372
D K + +E+ E + +++ + TLHA + D+++KM+ A + K
Sbjct: 1332 KQVEDEKNSFRE-QLEEEEEAKHNLEKQIATLHA---QVADMKKKMEDSVGCLETAEEVK 1387
Query: 373 IVLSEEEKAFLQKQK----IHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLITLQELQQ 428
L ++ + Q+ + +D+ +K T + Q+ L VD+ + + L++ Q+
Sbjct: 1388 RKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQE---LDDLLVDLDHQRQSACNLEKKQK 1444
Query: 429 ATKTVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAITEKIQNAE 488
+ ++ K +SA E R A R+K + + +A +A+ +K AE
Sbjct: 1445 KFDQLLAEE-KTISAKYAEERDRA------EAEAREKETKALSLARALEEAMEQK---AE 1494
Query: 489 VRRI-----------------------ELLNETSFRQQEISGFVAQIEKLTTELKEEEKA 525
+ R+ EL +Q++ Q+E+L EL+ E A
Sbjct: 1495 LERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDA 1554
Query: 526 FVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSNI 585
+ E L +++E + ++EK+++LV + +++ AE E + K+R + +
Sbjct: 1555 KLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREME-AELEDERKQRSMA----V 1609
Query: 586 ITAQRQEEDL--LNNHIFLFTRDFSRYISNMEDVKQELQQ-LRDQESKKNKDHFETLKNL 642
++ E DL L HI ++ I + ++ +++ +R+ + + +
Sbjct: 1610 AARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAK 1669
Query: 643 ENGFYINDQKADLLLLEN-----KKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIA 697
EN + +A+++ L+ ++ K ++ + + + R+L A
Sbjct: 1670 ENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEA 1729
Query: 698 QEAQYKDLWAEFQTTVKILVDNGEETLQDINNLTDKL---RERDEKMQHVSTWLRGSLEG 754
+ AQ ++ E Q +++ D ++ I+ + L R +K ++ L +
Sbjct: 1730 RIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKE 1789
Query: 755 LRLLVEQESPMDLLSKQQLRALLVTSKEEKTCQLSD 790
L++ +++ M+ K + +A +T+ E K QL +
Sbjct: 1790 LKVKLQE---MEGTVKSKYKA-SITALEAKIAQLEE 1821
Score = 86.3 bits (212), Expect = 1e-16
Identities = 140/679 (20%), Positives = 289/679 (42%), Gaps = 102/679 (15%)
Query: 151 KKITDLTKYNEALGEKQEELARKHARFVLSLNQTMEKKATTTVYINETYTKINLKREDIA 210
K + +++ E + K+EEL + + + + N+ E + + + E K+ L+ E +
Sbjct: 835 KPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAE---KLQLQ-EQLQ 890
Query: 211 LQKKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVKRMETYQKKKELDKLQTKMS 270
+ + EAEEL RA +KQEL ++ E E + + E K+Q +
Sbjct: 891 AETELCAEAEEL----RARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQ 946
Query: 271 KIKETVTVSAAVLSDHNLE-------IARLHESIRYWEQEVSELKKDLAILEAKLCFFTD 323
+++E + + LE + +L E E + +L K+ +LE ++ FT
Sbjct: 947 ELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTT 1006
Query: 324 NKEKLDDISNDEKNEFLNKIKQLVETL-----HAARMEYKDLREKMKT----------LA 368
N + +EK++ L K+K E + R E K +E KT L+
Sbjct: 1007 NLTE-----EEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLS 1061
Query: 369 RQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLITLQELQQ 428
Q + ++ + +Q K +E Q L + ++ +QK + +K + E + ELQ+
Sbjct: 1062 DQIAELQAQIAELKMQLAKKEEELQAALARVEEE---AAQKNMALKKIRELESQISELQE 1118
Query: 429 ------ATKTVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAITE 482
A++ ++Q + L LE T A ++ ++ ++ + + E
Sbjct: 1119 DLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEE 1178
Query: 483 KIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSKYEE 542
+ + E + E+ + S +E++ + Q +++ L++ ++ N+ L E+ +
Sbjct: 1179 EAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEV----K 1234
Query: 543 IFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLL------ 596
+ ++ ++ K +++ L +LQV ++ E R EL++ +T + E D +
Sbjct: 1235 VLLQGKGDSEHKRKKVEAQLQELQV---KFNEGERVRTELADKVTKLQVELDNVTGLLSQ 1291
Query: 597 -NNHIFLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNLENGFYINDQKADL 655
++ T+DFS S ++D ++ LQ+ N QK L
Sbjct: 1292 SDSKSSKLTKDFSALESQLQDTQELLQE------------------------ENRQKLSL 1327
Query: 656 LLLENKKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTTVKI 715
+ KLK+ +++ +RE E ++L +Q+ AQ D+ + + +V
Sbjct: 1328 ----STKLKQ----VEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGC 1379
Query: 716 LVDNGEETLQDINNLTDKLRERDE-------KMQHVSTWLRGSLEGLRLLV--EQESPMD 766
L + EE + + + L +R E K++ T L+ L+ L + + +++S +
Sbjct: 1380 L-ETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACN 1438
Query: 767 LLSKQQLRALLVTSKEEKT 785
L KQ+ L+ EEKT
Sbjct: 1439 LEKKQKKFDQLLA--EEKT 1455
Score = 69.3 bits (168), Expect = 1e-11
Identities = 142/709 (20%), Positives = 286/709 (40%), Gaps = 117/709 (16%)
Query: 65 EEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEECV--- 121
EE + + + KK+++ + + LE E KL T +K+ EE +
Sbjct: 925 EEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILE 984
Query: 122 ----RDARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARF 177
+ A+ L E + TE E + K + L +EA+ EE R+ +
Sbjct: 985 DQNCKLAKEKKLLEDRIAEFTTNLTEEEEK--SKSLAKLKNKHEAMITDLEERLRREEKQ 1042
Query: 178 VLSLNQTMEKKATTTVYINETYT---------KINLKREDIALQKKCIQEAEELMEKERA 228
L +T K + +++ K+ L +++ LQ + EE +K A
Sbjct: 1043 RQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMA 1102
Query: 229 EYLIRKQELTAQINEFENTREVKRMETYQKKKEL----DKLQTKMSKIKETVTVSAAVLS 284
IR EL +QI+E + E +R + +K+ ++L+ +++++T+ +AA
Sbjct: 1103 LKKIR--ELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAA--- 1157
Query: 285 DHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDE-KNEFLNKI 343
L R EQEV+ LKK L + + K + E + + +
Sbjct: 1158 QQELRSKR--------EQEVNILKKTL-----------EEEAKTHEAQIQEMRQKHSQAV 1198
Query: 344 KQLVETLHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKE 403
++L E L + +L + +TL + + L+ E K LQ + + +K++ Q+
Sbjct: 1199 EELAEQLEQTKRVKANLEKAKQTLENE-RGELANEVKVLLQGKGDSEHKRKKVEAQLQE- 1256
Query: 404 YFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSANLERESQRCVITQWKMACLR 463
+ +K E + + + TK Q ++ ++ L + +
Sbjct: 1257 -------LQVKFNEGERVRTELADKVTK--LQVELDNVTGLLSQSDSK------------ 1295
Query: 464 KKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIE----KLTTEL 519
++K+ + A+ ++Q+ + ELL E + ++ +S + Q+E +L
Sbjct: 1296 ------SSKLTKDFSALESQLQDTQ----ELLQEENRQKLSLSTKLKQVEDEKNSFREQL 1345
Query: 520 KEEEKAFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKL 579
+EEE+A N EK + ++ ++ K+K E+ V L+ AE+ ++ ++ L
Sbjct: 1346 EEEEEAKHNLEKQIATLHAQVADM--------KKKMEDSVGC---LETAEEVKRKLQKDL 1394
Query: 580 EELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETL 639
E LS QR EE + +E K LQQ D ++
Sbjct: 1395 EGLS-----QRHEEKV-------------AAYDKLEKTKTRLQQELDDLLVDLDHQRQSA 1436
Query: 640 KNLENGFYINDQKADLLLLENKKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIAQE 699
NLE +K D LL E K + ++ E +E + + + Q+
Sbjct: 1437 CNLEK----KQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQK 1492
Query: 700 AQYKDLWAEFQTTVKILVDNGEETLQDINNLTDKLRERDEKMQHVSTWL 748
A+ + L +F+T ++ L+ + ++ + ++ L R +++++ + T L
Sbjct: 1493 AELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQL 1541
Score = 55.8 bits (133), Expect = 2e-07
Identities = 94/488 (19%), Positives = 191/488 (39%), Gaps = 53/488 (10%)
Query: 340 LNKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFI 399
L ++ + E + A E +REK + + + + + +K ++ ++ Q +
Sbjct: 837 LLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELC 896
Query: 400 SQKEYFLSQKRVDIKNMEEGLITLQ----------ELQQATKTVYQQQIKILSANLERES 449
++ E ++ + +EE L+ + QA K QQ I+ L LE E
Sbjct: 897 AEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEE 956
Query: 450 QRCVITQWKMACLRKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFV 509
R+K +A+++ + E+ E + +L E + I+ F
Sbjct: 957 SA-----------RQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFT 1005
Query: 510 AQI------EKLTTELKEEEKAFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLP 563
+ K +LK + +A + + ++ K + K + + +L + +
Sbjct: 1006 TNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIA 1065
Query: 564 QLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQQ 623
+LQ E K + K EE A+ +EE N R+ IS +++ + +
Sbjct: 1066 ELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERA 1125
Query: 624 LRDQESKKNKDHFETLKNLENGFYIN-DQKADLLLLENKKLKEYILYLKNNIEKYREGQE 682
R++ K+ +D E L+ L+ D A L +K+ +E + LK +E+ + E
Sbjct: 1126 SRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQE-VNILKKTLEEEAKTHE 1184
Query: 683 ALMHTSNDLSRQLIAQEAQYKDLWAEFQTTVKILVDNGEETLQDINNLTDKLRERDEKMQ 742
A + Q + + A+ E VK ++ ++TL++ ER E
Sbjct: 1185 AQIQEMRQKHSQAVEELAEQ----LEQTKRVKANLEKAKQTLEN---------ERGELAN 1231
Query: 743 HVSTWLRGSLEGLRLLVEQESPMDLLSKQQLRALLVTSKEEKTCQLSDLVIPNYATNIQL 802
V L+G + + E+ + Q+L+ + +T +L+D V T +Q+
Sbjct: 1232 EVKVLLQGKGDSEHKRKKVEAQL-----QELQVKFNEGERVRT-ELADKV-----TKLQV 1280
Query: 803 NIDTYLGL 810
+D GL
Sbjct: 1281 ELDNVTGL 1288
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 93.6 bits (231), Expect = 7e-19
Identities = 131/646 (20%), Positives = 292/646 (45%), Gaps = 81/646 (12%)
Query: 112 SIKRELEECVRDARRLNLFEINTIKMRITRTENEIELLKKKITDL-TKYNEA---LGEKQ 167
+++RELE V R L + ++M + +++ ++ L+ + DL ++ +++ GE +
Sbjct: 120 ALRRELEAQVHTIRILTC-QKTELQMALYYSQHAVKQLEGEARDLISRLHDSWKFAGELE 178
Query: 168 EELA------RKHARFVLSLNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEE 221
+ L+ +K R++ L T E+ A + T T LK ++ LQ+K +
Sbjct: 179 QALSAVATQKKKADRYIEEL--TKERDALSLELYRNTITDEELKEKNAKLQEKL-----Q 231
Query: 222 LMEKERAEYLIRKQELTAQINEFENTREVKRM--ETYQKKKELDKLQTKMSKIKETVTVS 279
L+E E++E + +EL ++ + +++ E KEL + K+ E +
Sbjct: 232 LVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELW 291
Query: 280 AAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEF 339
+ ++ R E I+ WE+++ E ++ + E K+ + + +++ +++ +
Sbjct: 292 NRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKM 351
Query: 340 LNKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFI 399
+ + + E R + + + EK + + RQ +++ +EEK ++K+H++ + I
Sbjct: 352 RRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEK-----I 406
Query: 400 SQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSANLERESQRCVITQWKM 459
++E +KR + EE + ++ Q+ +++Q+ KI RE + + Q
Sbjct: 407 REQE----EKRQE----EEKIREQEKRQEQEAKMWRQEEKI------REQEEKIREQ--- 449
Query: 460 ACLRKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTEL 519
KK R KI + EKI+ E R+ + E +RQ+E ++
Sbjct: 450 ---EKKMWRQEEKIHEQ-----EKIREEEKRQEQ---EEMWRQEE-------------KI 485
Query: 520 KEEEKAFVNKEKMLMKE--LSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRR 577
E+E+ + KEKM +E + K EE ++ + +E+EE++ E ++ E++ +E+
Sbjct: 486 HEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEE 545
Query: 578 KLEELSNIITAQR-QEEDLLNNHIFLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHF 636
E + ++ EE+ R + E V ++ +++R+QE K+ +
Sbjct: 546 MWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEE 605
Query: 637 ETLKNLENGFYINDQKADLLLLENKKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLI 696
+ K E I +Q+ + + + +K++E ++ E +E +E + + Q
Sbjct: 606 KMWKQEEK---IREQE-EKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEE 661
Query: 697 AQEAQYKDLWAEFQTTVKILVDNGEETLQDINNLTDKLRERDEKMQ 742
+ Q + +W + + E + I +K+RE++E MQ
Sbjct: 662 KMQEQEETMWRQEEKI--------REQEKKIREQEEKIREQEEMMQ 699
Score = 86.7 bits (213), Expect = 8e-17
Identities = 107/554 (19%), Positives = 245/554 (44%), Gaps = 47/554 (8%)
Query: 88 TIDLLEIESMELNKLYYLLETLPNSIKRELEECVRDARRLNLF-EINTIKMRITRTENEI 146
T + L+ ++ +L + L+E+ + I+ ++E R R L ++ E+
Sbjct: 215 TDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKEL 274
Query: 147 ELLKKKITDLTKYNEALGEKQEELARKHARFVLSLNQTMEKKATTTVYINETYTKINLKR 206
+ + K+ + NE ++ K R + + EK I E KI +
Sbjct: 275 QSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQE 334
Query: 207 EDIALQKKCIQEAEELMEK------ERAEYLIRKQELTAQINEFENTREVKRMETYQKKK 260
E + Q++ + E EE M + E+ E + R++E+ + E +E E +K +
Sbjct: 335 EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIR 394
Query: 261 ELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCF 320
EL++ + KI+E + E ++ E + EQE +++ I
Sbjct: 395 ELEEKMHEQEKIREQ--------EEKRQEEEKIREQEKRQEQEAKMWRQEEKI------- 439
Query: 321 FTDNKEKLDDISNDEKNEFLNKIKQLVETLHAA-RMEYKDLREKMKTLARQYKIVLSEEE 379
+E+ + I EK K+ + E +H ++ ++ R++ + + RQ + + E+E
Sbjct: 440 ----REQEEKIREQEK-----KMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKI-HEQE 489
Query: 380 KAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIK 439
+ + QK+K+H++ +K I ++E + ++ I+ EE + +E + ++Q +
Sbjct: 490 EIWRQKEKMHEQEEK----IRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEE 545
Query: 440 ILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAI---TEKIQNAEVRRIELLN 496
+ + Q + + K K R KI+ + + + EKI+ E +R E
Sbjct: 546 MWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEE 605
Query: 497 ETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSKYEEIFVKETQINKEKEE 556
+ ++++I +I++ +++E+E+ +E+M ++ EE ++ + E+EE
Sbjct: 606 KMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQ----EEKMGEQEEKMCEQEE 661
Query: 557 ELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMED 616
++ E + E++ +E+ +K+ E I R++E+++ + E
Sbjct: 662 KMQEQEETMWRQEEKIREQEKKIREQEEKI---REQEEMMQEQEEKMWEQEEKMCEQEEK 718
Query: 617 VKQELQQLRDQESK 630
++++ +++R QE K
Sbjct: 719 MQEQEEKMRRQEEK 732
Score = 74.3 bits (181), Expect = 4e-13
Identities = 119/583 (20%), Positives = 248/583 (42%), Gaps = 86/583 (14%)
Query: 217 QEAEELMEKERAEYLIRKQELTAQINEFENTREVKRMETYQKK-----KELDKLQTKMSK 271
Q A + +E E + + R + E E + + T +KK +EL K + +S
Sbjct: 150 QHAVKQLEGEARDLISRLHDSWKFAGELEQA--LSAVATQKKKADRYIEELTKERDALSL 207
Query: 272 IKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDI 331
T++ L + N A+L E ++ E E SE++ ++ L+ KL K L
Sbjct: 208 ELYRNTITDEELKEKN---AKLQEKLQLVESEKSEIQLNVKELKRKL---ERAKLLLPQQ 261
Query: 332 SNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDE 391
+ + L K Q V A++E +L ++ +EEK + Q++KI +
Sbjct: 262 QLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQ---------QQEEKMWRQEEKIQEW 312
Query: 392 NQKQLTFISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSANLER-ESQ 450
+K I ++E + ++ I+ EE + +E+ + ++Q +++ E+ Q
Sbjct: 313 EEK----IQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQ 368
Query: 451 RCVITQWKMACLRKKHARWTAKIKA----EIQAITEKIQNAEVRRIE--LLNETSFRQQE 504
++ + + R++ W + K E EKI+ E +R E + E RQ++
Sbjct: 369 EEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQ 428
Query: 505 ISGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQ 564
+ Q EK+ ++EEK ++KM +E +E+ ++E + ++++EE+ +
Sbjct: 429 EAKMWRQEEKIR---EQEEKIREQEKKMWRQEEKIHEQEKIREEE-KRQEQEEMWRQEEK 484
Query: 565 LQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQQL 624
+ E+ +++K + E+ I ++QEE + E ++++ +++
Sbjct: 485 IHEQEEIWRQKEKMHEQEEKI---RKQEEKVWRQE---------------EKIREQEEKI 526
Query: 625 RDQESKKNKDHFETLKNLENGFYINDQKADLLLLENKKLKEYILYLKNNIEKYREGQEAL 684
R+QE K + + + E + E +K +E + EK RE +E +
Sbjct: 527 REQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKV 586
Query: 685 MHTSNDLSRQLIAQEAQYKDLWAEFQTTVKILVDNGEETLQDINNLTDKLRERDEKMQHV 744
+ Q ++ Q + +W + +K+RE++EK+Q
Sbjct: 587 WRQEEKIREQEEKRQEQEEKMWKQ----------------------EEKIREQEEKIQEQ 624
Query: 745 STWLRGSLEGLRLLVEQESPMDLLSKQQLRALLVTSKEEKTCQ 787
+R E +R EQE ++ +Q+ + + +EEK C+
Sbjct: 625 EEKIREQEEKIR---EQE---EMTQEQEEK---MGEQEEKMCE 658
Score = 52.0 bits (123), Expect = 2e-06
Identities = 58/311 (18%), Positives = 143/311 (45%), Gaps = 32/311 (10%)
Query: 118 EECVRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARF 177
EE + + ++ E + + R E +I + ++ + E + E++E++ ++ +
Sbjct: 457 EEKIHEQEKIREEEKRQEQEEMWRQEEKIH----EQEEIWRQKEKMHEQEEKIRKQEEKV 512
Query: 178 VLSLNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKERA--------- 228
+ E++ I E K+ + E I Q++ +E E++ E+E+
Sbjct: 513 WRQEEKIREQEEK----IREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQ 568
Query: 229 -EYLIRKQELTAQINEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHN 287
+ + R++E + E +E K E +K++E ++ KM K +E + + +
Sbjct: 569 EDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEE---KMWKQEEKIREQEEKIQEQE 625
Query: 288 LEIARLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLV 347
+I E IR E+ E ++ + E K+C + +EK+ + ++ + +++
Sbjct: 626 EKIREQEEKIREQEEMTQEQEEKMGEQEEKMC---EQEEKMQE----QEETMWRQEEKIR 678
Query: 348 ETLHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLS 407
E R + + +RE+ + + Q + + +EEK Q++K+ ++ +K + ++E +
Sbjct: 679 EQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEK----MRRQEEKMW 734
Query: 408 QKRVDIKNMEE 418
++ V ++ EE
Sbjct: 735 EQEVRLRQQEE 745
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 93.6 bits (231), Expect = 7e-19
Identities = 147/746 (19%), Positives = 322/746 (43%), Gaps = 87/746 (11%)
Query: 79 KKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEECVRDARRLNLFEINTIKMR 138
K L+E + +D L++E ++N L + K +LE+ V D +L + ++M
Sbjct: 999 KALQEAHQQALDDLQVEEDKVNSL--------SKSKVKLEQQVDDLEG-SLEQEKKVRMD 1049
Query: 139 ITRT----ENEIELLKKKITDLTKYNEALGEKQEELARKHARFVLSLNQTMEKKATTTVY 194
+ R E +++L ++ I DL N+ L + EE +K + N +E + +
Sbjct: 1050 LERAKRKLEGDLKLTQESIMDLE--NDKL--QLEEKLKKKEFDINQQNSKIEDEQVLALQ 1105
Query: 195 INETYTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVKRME 254
+ + + + E++ + + + A +EK R++ +E++ ++ E V+
Sbjct: 1106 LQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEM 1165
Query: 255 TYQKKKELDKLQTKMSKIK-ETVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAI 313
+++ E K++ + + + +AA+ H +A L E I ++ +L+K+ +
Sbjct: 1166 NKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKS- 1224
Query: 314 LEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKI 373
+ K +LDD++++ +E + A+ + + ++ A +Y++
Sbjct: 1225 ---------EFKLELDDVTSN------------MEQIIKAKANLEKVSRTLEDQANEYRV 1263
Query: 374 VLSEEEKAF----LQKQKIHDENQKQLTFISQKEYFLSQ----KRVDIKNMEEGLITLQE 425
L E +++ Q+ K+ EN + + +KE +SQ K + ME+ L+E
Sbjct: 1264 KLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEE 1323
Query: 426 LQQATKTVY------QQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQA 479
+A + + +L E E++ Q ++ + A+W K + +
Sbjct: 1324 EGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQ 1383
Query: 480 ITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEE-EKAFVNKEKM------ 532
TE+++ A+ + + L + + ++ + +EK L+ E E V+ E+
Sbjct: 1384 RTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAA 1443
Query: 533 LMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQE-YKEKRRKLEELSNIITAQRQ 591
L K+ +++I + Q +E + EL + + E +K K E L ++ T +R+
Sbjct: 1444 LDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRE 1503
Query: 592 EEDLLNNHIFLFTR--DFSRYISNMEDVKQELQ------QLRDQESKKNKDHFETLKNLE 643
++L L + + + + +E V+++L+ Q +E++ + +H E K L
Sbjct: 1504 NKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEG-KILR 1562
Query: 644 NGFYINDQKADLLLLENKKLKEYILYLKNN---IEKYREGQEALMHTSNDLSR------- 693
N KA++ +K +E +N+ ++ + +A + N++ R
Sbjct: 1563 AQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEG 1622
Query: 694 ---QLIAQEAQYKDLWAEFQTTVKILVDNGEET---LQDINNLTDKLRERDEKMQHVSTW 747
++ Q + + AE Q VK L ++T L D D L+E ++ +
Sbjct: 1623 DLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNL 1682
Query: 748 LRGSLEGLRLLVEQESPMDLLSKQQL 773
L+ LE LR +VEQ L++Q+L
Sbjct: 1683 LQAELEELRAVVEQTERSRKLAEQEL 1708
Score = 67.8 bits (164), Expect = 4e-11
Identities = 160/845 (18%), Positives = 327/845 (38%), Gaps = 172/845 (20%)
Query: 52 VEQSLQSDYFKCNEEAKIFLKDIAVAV---KKLEEMRKATIDLLEIESMELNKLYYLLET 108
+E+ L+ F N++ + +A+ KKL+E +A I+ LE E +E
Sbjct: 1078 LEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKE-NQARIEELEEELEAERTARAKVEK 1136
Query: 109 LPNSIKRELEEC---VRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEALGE 165
L + + RELEE + +A +I K R E E + +++ + + T +EA
Sbjct: 1137 LRSDLSRELEEISERLEEAGGATSVQIEMNKKR----EAEFQKMRRDLEEATLQHEATAA 1192
Query: 166 KQEELARKHARFVLSLNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEK 225
L +KHA V L + ++ + + ++ L+ +D+ + I +A+ +EK
Sbjct: 1193 A---LRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEK 1249
Query: 226 -------ERAEYLIRKQELTAQINEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTV 278
+ EY ++ +E +N+F R + E + ++L++ + +S++
Sbjct: 1250 VSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLS 1309
Query: 279 SAAVLSD----------------HNLEIARLH-ESIRYWEQEVSELKKDLA--------- 312
+ D H L+ AR + +R +E +E K +L
Sbjct: 1310 YTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSE 1369
Query: 313 ILEAKLCFFTDNKEKLDDISNDEKN------------EFLN-KIKQLVETLHAARMEYKD 359
+ + + + TD ++ +++ +K E +N K L +T H + E +D
Sbjct: 1370 VAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIED 1429
Query: 360 LR---EKMKTLA-------RQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQK 409
L E+ A R + +L+E ++ + + Q + +QK+ +S + + L
Sbjct: 1430 LMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNA 1489
Query: 410 -----------RVDIKNMEEGLITLQE-----------------------------LQQA 429
+ + KN++E + L E L++A
Sbjct: 1490 YEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEA 1549
Query: 430 TKTVYQQQIKILSANLERESQRCVITQW------KMACLRKKHARWTAKIKAEIQAITEK 483
++ ++ KIL A LE + I + +M ++ H R ++ + A T
Sbjct: 1550 EASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRS 1609
Query: 484 IQNAEVRRIEL-----LNETSFRQQEISGFVAQIEK---------------------LTT 517
EV R++ LNE + + A+ +K
Sbjct: 1610 --RNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRAND 1667
Query: 518 ELKEEEKAFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRR 577
+LKE + +L EL + + + + K E+EL+E ++Q+ +
Sbjct: 1668 DLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLIN 1727
Query: 578 KLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQQLRD-----QESKKN 632
+ +++ + +T + E + + I++ + +EL++ +D + KKN
Sbjct: 1728 QKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKN 1787
Query: 633 KDHFETLKNLENGFYINDQKADLLLLENK----KLKEYILYLKNNIE-KYREGQEAL--M 685
+ +T+K+L++ D+ + L K KL+ + L+ +E + + E++ M
Sbjct: 1788 ME--QTIKDLQHRL---DEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGM 1842
Query: 686 HTSNDLSRQLIAQEAQYK-------DLWAEFQTTVKILVDNGEETLQDINNLTDKLRERD 738
S ++L Q + K DL + Q VK EE + N K R
Sbjct: 1843 RKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFR--- 1899
Query: 739 EKMQH 743
K+QH
Sbjct: 1900 -KVQH 1903
Score = 66.6 bits (161), Expect = 9e-11
Identities = 119/561 (21%), Positives = 230/561 (40%), Gaps = 72/561 (12%)
Query: 197 ETYTKINLKREDIALQKKCIQEAE---ELMEKERAEYLIRKQELTAQINEFENTREVKRM 253
ET ++ +E+ K+ ++++E + +E++ L K +L Q+ ++
Sbjct: 846 ETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEE 905
Query: 254 ETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAI 313
Q K +L+ K+ ++ E L D A L R E E SELKKD+
Sbjct: 906 RCDQLIKNKIQLEAKVKEMNER-------LEDEEEMNAELTAKKRKLEDECSELKKDIDD 958
Query: 314 LEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKI 373
LE L EK EK+ NK+K L E E L E + L ++ K
Sbjct: 959 LELTLA----KVEK-------EKHATENKVKNLTE-------EMAGLDEIIAKLTKEKKA 1000
Query: 374 VLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTV 433
+ Q+ H + L K LS+ +V ++ + L E ++ +
Sbjct: 1001 L-----------QEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMD 1049
Query: 434 YQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKA---EIQAITEKIQNAEVR 490
++ + L +L+ +TQ + L + K+K +I KI++ +V
Sbjct: 1050 LERAKRKLEGDLK-------LTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVL 1102
Query: 491 RIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKM---LMKELSKYEEIFVK- 546
++L Q+++ A+IE+L EL+ E A EK+ L +EL + E +
Sbjct: 1103 ALQL-------QKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEA 1155
Query: 547 ------ETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEE-DLLNNH 599
+ ++NK++E E + L+ A +++ L + A+ E+ D L
Sbjct: 1156 GGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRV 1215
Query: 600 IFLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNLENGFYINDQKADLLLLE 659
++ S + ++DV ++Q+ ++ K TL++ N + + ++A L +
Sbjct: 1216 KQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVS-RTLEDQANEYRVKLEEAQRSLND 1274
Query: 660 NKKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTTVKILVDN 719
+ + + + E +EAL+ + L+R ++ Q +DL + + K +
Sbjct: 1275 FTTQRAKLQTENGELARQLEEKEALI---SQLTRGKLSYTQQMEDLKRQLEEEGK-AKNA 1330
Query: 720 GEETLQDINNLTDKLRERDEK 740
LQ + D LRE+ E+
Sbjct: 1331 LAHALQSARHDCDLLREQYEE 1351
Score = 59.3 bits (142), Expect = 1e-08
Identities = 105/423 (24%), Positives = 182/423 (43%), Gaps = 57/423 (13%)
Query: 391 ENQKQLTFISQKEYF------LSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSAN 444
E +K++ + KE F L + K +EE +++L LQ+ K Q Q++ N
Sbjct: 846 ETEKEMA--TMKEEFGRIKETLEKSEARRKELEEKMVSL--LQE--KNDLQLQVQAEQDN 899
Query: 445 LERESQRCVITQWKMACLRKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQE 504
L +RC ++ K +++A+++ + E++++ E EL + + E
Sbjct: 900 LNDAEERCD------QLIKNK-----IQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDE 948
Query: 505 ISGFVAQIEKLTTELKEEEK---AFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEY 561
S I+ L L + EK A NK K L +E++ +EI K T+ K +E +
Sbjct: 949 CSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQA 1008
Query: 562 LPQLQVAEQE---YKEKRRKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNME-DV 617
L LQV E + + + KLE+ + + ++E + D R +E D+
Sbjct: 1009 LDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVR-------MDLERAKRKLEGDL 1061
Query: 618 KQELQQLRDQESKKNKDHFETLKNLENGFYINDQKAD------LLLLENKKLKE---YIL 668
K + + D E+ K + E LK E F IN Q + L L KKLKE I
Sbjct: 1062 KLTQESIMDLENDKLQLE-EKLKKKE--FDINQQNSKIEDEQVLALQLQKKLKENQARIE 1118
Query: 669 YLKNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTTVKILVDNGEETLQDIN 728
L+ +E R + + +DLSR+L +E + A T+V+I ++ E +
Sbjct: 1119 ELEEELEAERTARAKVEKLRSDLSREL--EEISERLEEAGGATSVQIEMNKKREA--EFQ 1174
Query: 729 NLTDKLRERDEKMQHVSTWLRGSLEGLRLLVEQESPMDLLSKQQLRALLVTSKEEKTCQL 788
+ L E +QH +T + + E +D L Q+++ L K E +L
Sbjct: 1175 KMRRDLEE--ATLQHEATAAALRKKHADSVAELGEQIDNL--QRVKQKLEKEKSEFKLEL 1230
Query: 789 SDL 791
D+
Sbjct: 1231 DDV 1233
>gi|33946313 ninein isoform 4 [Homo sapiens]
Length = 2096
Score = 93.6 bits (231), Expect = 7e-19
Identities = 166/744 (22%), Positives = 322/744 (43%), Gaps = 123/744 (16%)
Query: 140 TRTE-----NEIELLKKKITDLTKYNEALGEKQEELARKHARFVLSLNQTMEKKATTTVY 194
TRTE N+I L++++ L + EK+++L F +S+ ++KK
Sbjct: 1195 TRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLL-----FDVSV---LKKKLKMLER 1246
Query: 195 INETYTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVKRME 254
I E K L ED++ + C+QE +ME E L +ELTA++ F E+K+ME
Sbjct: 1247 IPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEV--FRLQDELKKME 1304
Query: 255 TYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAIL 314
E+ + + K + V + L N+ + RL I ++ V + + D +
Sbjct: 1305 ------EVTETFLSLEKSYDEVKIENEEL---NVLVLRLQGKIEKLQESVVQ-RCDCCLW 1354
Query: 315 EAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYK----------DLREKM 364
EA L +N E D + + N+ L + V ++H E K L EK+
Sbjct: 1355 EASL----ENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKV 1410
Query: 365 KT--LARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLIT 422
K +A + + + +E+ +Q Q I +EN L F Q ++F Q + I +E
Sbjct: 1411 KAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGF--QDKHF--QHQATIAELELEKTK 1466
Query: 423 LQELQQATK---TVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKAE-IQ 478
LQEL + K T+ +Q +LS + E + ++ ++ C + + ++E +Q
Sbjct: 1467 LQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQ 1526
Query: 479 AITEKIQNAEVRRIELLNE----TSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLM 534
++N I LNE ++ + ++G ++ + T +K+E A + L
Sbjct: 1527 QENSILRN----EITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLK 1582
Query: 535 KELS----KYEEIFVKETQI------NKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSN 584
K++S K +++ ++ T++ N+EK +EL + L ++ + ++E + LEE
Sbjct: 1583 KQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEM-LCQKEKEPGNSALEE--- 1638
Query: 585 IITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQ---QLRDQESKKNKDHFETLKN 641
+ QE+ L + S +S++E E++ + QE+ KD E +K
Sbjct: 1639 ----REQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQ 1694
Query: 642 LENGFYIND--QKADLLLLENKKL---KEYI--------------LYLKNNIEKYREGQE 682
L ++D QK +L N+KL KE + L++ I ++ Q+
Sbjct: 1695 LHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQK 1754
Query: 683 ALMHTSNDLSRQLIAQEAQYKDL----------WAEFQTTVKILVDNGEETLQDINNLTD 732
+ H S L QL+A + + ++L + ++ +++ E Q++ +L
Sbjct: 1755 SWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHK 1814
Query: 733 KLRERDEK--MQHVSTWLRG--------SLEGLRLLVEQESPMDLLSKQQLRALL----- 777
+L+ K ++T G S + L L+ +E + ++L+ ++
Sbjct: 1815 QLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKA 1874
Query: 778 -VTSKEEKTCQLSDLVIPNYATNI 800
+T EK QL ++P + ++
Sbjct: 1875 ELTHSREKVRQLESNLLPKHQKHL 1898
Score = 80.1 bits (196), Expect = 8e-15
Identities = 155/757 (20%), Positives = 315/757 (41%), Gaps = 120/757 (15%)
Query: 66 EAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPNSI--KRELEECVRD 123
+ I L ++ +A++ + K +I + S + ++ +LLE + + K +L +
Sbjct: 340 DGNINLTELTLALENELLVTKNSIHQAALASFKA-EIRHLLERVDQVVREKEKLRSDLDK 398
Query: 124 ARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFV----- 178
A +L + + E E +K+ + +Y E + + EL ++ + +
Sbjct: 399 AEKLKSLMASEVDDHHAAIERRNEYNLRKLDE--EYKERIAALKNELRKEREQILQQAGK 456
Query: 179 --LSLNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKER--------- 227
L L Q +EK T YI + ++LK E+ L+ + ++ AE+L E E
Sbjct: 457 QRLELEQEIEKAKTEENYIRDRLA-LSLK-ENSRLENELLENAEKLAEYENLTNKLQRNL 514
Query: 228 ---------------AEYLIRKQELTAQINEFENTREV---------KRMETYQKKKELD 263
AE+ ++++ LT NE+E V +E Y+ + +
Sbjct: 515 ENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVL 574
Query: 264 KLQTKMSKIKETVTVSAAVLSDHNL---EIARLHESIR---YWEQEVSELKKDLAILEAK 317
+L K S +E S + +H L E L+ SI EQ + +D+ L +
Sbjct: 575 RLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLE 634
Query: 318 LCFFTDNKEK-LDDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLS 376
L + EK LD+ K N ++ H + DL+ ++ L Q ++
Sbjct: 635 LEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKE 694
Query: 377 ---------EEEKAFLQ----KQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLIT- 422
EEEK LQ ++K H + + +L + + L+Q + + EGL +
Sbjct: 695 AHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSS 754
Query: 423 ------LQELQQATKTVYQQQIKIL--SANLERESQRCVITQWKMACLRKKHA------- 467
++ L Q + +Q+Q+ L LE+E R + + L++
Sbjct: 755 AWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECN 814
Query: 468 RWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFV 527
R T++I+A+ Q+ +K+ ++ L E +RQ +++ L + +EE+ +
Sbjct: 815 RRTSQIEAQFQSDCQKVTERCESALQSL-EGRYRQ--------ELKDLQEQQREEKSQWE 865
Query: 528 NKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYK--------EKRRKL 579
++ L +E ++ +E+ +KET + +EK LV + ++ E+ YK E+++ L
Sbjct: 866 FEKDELTQECAEAQEL-LKET-LKREKTTSLV-LTQEREMLEKTYKEHLNSMVVERQQLL 922
Query: 580 EELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDV-----------KQELQQLRDQE 628
++L ++ ++ LL++ I R + E+V Q L++L +
Sbjct: 923 QDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEH 982
Query: 629 SKKNKDHFETLKNLENGFYINDQKADLLLLENKKLKEYILYLKNNIEKYREGQEALMHTS 688
++ ++ L +EN + AD E ++ I L++ I++ ++ L
Sbjct: 983 DQERQEMMSKLLAMENIHKATCETAD---RERAEMSTEISRLQSKIKEMQQATSPLSMLQ 1039
Query: 689 NDLSRQLIAQEAQYKD-LWAEFQTTVKILVDNGEETL 724
+ Q+I +E D + Q ++L +NG+ L
Sbjct: 1040 SGC--QVIGEEEVEGDGALSLLQQGEQLLEENGDVLL 1074
Score = 55.8 bits (133), Expect = 2e-07
Identities = 78/416 (18%), Positives = 186/416 (44%), Gaps = 43/416 (10%)
Query: 65 EEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRE-----LEE 119
EE K + D+ + ++++ ++LL ES +L + +L ++ E L+
Sbjct: 1495 EELKAMMHDLQITCSEMQQK----VELLRYESEKLQQENSILRNEITTLNEEDSISNLKL 1550
Query: 120 CVRDARRLNLFE-INTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHAR-- 176
+ + +++ T+K + +E LKK+I++L N+ L + EL++K+++
Sbjct: 1551 GTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQ 1610
Query: 177 -FVLSLNQTM-------EKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKERA 228
+ LNQ + EK+ + K NLK E ++C ++ L+ A
Sbjct: 1611 EKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEE----LERCKVQSSTLVSSLEA 1666
Query: 229 EYLIRKQELTAQINEFEN---TREVKRMETYQKKKELDKLQTKMSKI----------KET 275
E + + ++ I + EN E+++M+ + +L Q K+S + KE
Sbjct: 1667 E--LSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEA 1724
Query: 276 VTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDE 335
++ D + + L I +QE + A L+++L ++EK+ ++ +
Sbjct: 1725 LSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQL---VASQEKVQNLEDTV 1781
Query: 336 KNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQ 395
+N L ++ ++ L + E + L++++ +L +Q + + + NQ++
Sbjct: 1782 QNVNL-QMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQK 1840
Query: 396 LTFISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSANLERESQR 451
+ ++ +++++ + E L T+ + +A T +++++ L +NL + Q+
Sbjct: 1841 RLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQK 1896
Score = 51.2 bits (121), Expect = 4e-06
Identities = 134/658 (20%), Positives = 264/658 (40%), Gaps = 109/658 (16%)
Query: 202 INLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVKRMETYQKKKE 261
INL +AL+ + + + + A + + L +++ Q +E
Sbjct: 343 INLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVD--------------QVVRE 388
Query: 262 LDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHE-SIRYWEQEVSE----LKKDLAILEA 316
+KL++ + K ++ ++ A+ + DH+ I R +E ++R ++E E LK +L E
Sbjct: 389 KEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELR-KER 447
Query: 317 KLCFFTDNKEKLD-------------------DISNDEKNEFLNKIKQLVETLHAARMEY 357
+ K++L+ +S E + N++ + E L EY
Sbjct: 448 EQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKL----AEY 503
Query: 358 KDLREKMK-----TLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVD 412
++L K++ LA ++ + + FLQ++++ Q+ +++ + Q +VD
Sbjct: 504 ENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERL-----TQMRNEYERQCRVLQDQVD 558
Query: 413 --IKNMEEGLITLQELQQATKTVYQQQIKILSANLERE----SQRC-----------VIT 455
+EE + L+ K ++++ S +E E S+ C VI
Sbjct: 559 ELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIE 618
Query: 456 QWK------MACLR---KKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEIS 506
Q K + CLR + R K E +K Q +R E NET +++IS
Sbjct: 619 QMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHE--NETHTLEKQIS 676
Query: 507 GF---VAQIEKLTTELKE--EEKAFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEY 561
+A+++ LKE E ++E+ ++ EE + ++ + E EL
Sbjct: 677 DLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKAR 736
Query: 562 LPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQEL 621
L Q Q + + +E + + QE L H T ++ E++++EL
Sbjct: 737 LTQAQASFEREREGLQSSAWTEEKVRGLTQE--LEQFHQEQLTSLVEKHTLEKEELRKEL 794
Query: 622 QQLRDQESKKNKDHFETLKN-----LENGFYINDQK------ADLLLLENKKLKEYILYL 670
+ +E ++ ++ ET N +E F + QK + L LE + +E L
Sbjct: 795 LEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQE----L 850
Query: 671 KNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTTVKILVDNGEETLQDI-NN 729
K+ E+ RE + ++L+++ + K+ +TT +L E + +
Sbjct: 851 KDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEH 910
Query: 730 LTDKLRERDEKMQHVSTWLRGSLEGLRLLVEQESPMDLLSKQQLRALLVTSKEEKTCQ 787
L + ER + +Q + S LL +Q + K++LR +EE CQ
Sbjct: 911 LNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELR-----EREEVLCQ 963
>gi|33946321 ninein isoform 5 [Homo sapiens]
Length = 2090
Score = 93.6 bits (231), Expect = 7e-19
Identities = 166/744 (22%), Positives = 322/744 (43%), Gaps = 123/744 (16%)
Query: 140 TRTE-----NEIELLKKKITDLTKYNEALGEKQEELARKHARFVLSLNQTMEKKATTTVY 194
TRTE N+I L++++ L + EK+++L F +S+ ++KK
Sbjct: 1189 TRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLL-----FDVSV---LKKKLKMLER 1240
Query: 195 INETYTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVKRME 254
I E K L ED++ + C+QE +ME E L +ELTA++ F E+K+ME
Sbjct: 1241 IPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEV--FRLQDELKKME 1298
Query: 255 TYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAIL 314
E+ + + K + V + L N+ + RL I ++ V + + D +
Sbjct: 1299 ------EVTETFLSLEKSYDEVKIENEEL---NVLVLRLQGKIEKLQESVVQ-RCDCCLW 1348
Query: 315 EAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYK----------DLREKM 364
EA L +N E D + + N+ L + V ++H E K L EK+
Sbjct: 1349 EASL----ENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKV 1404
Query: 365 KT--LARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLIT 422
K +A + + + +E+ +Q Q I +EN L F Q ++F Q + I +E
Sbjct: 1405 KAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGF--QDKHF--QHQATIAELELEKTK 1460
Query: 423 LQELQQATK---TVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKAE-IQ 478
LQEL + K T+ +Q +LS + E + ++ ++ C + + ++E +Q
Sbjct: 1461 LQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQ 1520
Query: 479 AITEKIQNAEVRRIELLNE----TSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLM 534
++N I LNE ++ + ++G ++ + T +K+E A + L
Sbjct: 1521 QENSILRN----EITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLK 1576
Query: 535 KELS----KYEEIFVKETQI------NKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSN 584
K++S K +++ ++ T++ N+EK +EL + L ++ + ++E + LEE
Sbjct: 1577 KQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEM-LCQKEKEPGNSALEE--- 1632
Query: 585 IITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQ---QLRDQESKKNKDHFETLKN 641
+ QE+ L + S +S++E E++ + QE+ KD E +K
Sbjct: 1633 ----REQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQ 1688
Query: 642 LENGFYIND--QKADLLLLENKKL---KEYI--------------LYLKNNIEKYREGQE 682
L ++D QK +L N+KL KE + L++ I ++ Q+
Sbjct: 1689 LHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQK 1748
Query: 683 ALMHTSNDLSRQLIAQEAQYKDL----------WAEFQTTVKILVDNGEETLQDINNLTD 732
+ H S L QL+A + + ++L + ++ +++ E Q++ +L
Sbjct: 1749 SWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHK 1808
Query: 733 KLRERDEK--MQHVSTWLRG--------SLEGLRLLVEQESPMDLLSKQQLRALL----- 777
+L+ K ++T G S + L L+ +E + ++L+ ++
Sbjct: 1809 QLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKA 1868
Query: 778 -VTSKEEKTCQLSDLVIPNYATNI 800
+T EK QL ++P + ++
Sbjct: 1869 ELTHSREKVRQLESNLLPKHQKHL 1892
Score = 80.1 bits (196), Expect = 8e-15
Identities = 155/757 (20%), Positives = 315/757 (41%), Gaps = 120/757 (15%)
Query: 66 EAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPNSI--KRELEECVRD 123
+ I L ++ +A++ + K +I + S + ++ +LLE + + K +L +
Sbjct: 334 DGNINLTELTLALENELLVTKNSIHQAALASFKA-EIRHLLERVDQVVREKEKLRSDLDK 392
Query: 124 ARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFV----- 178
A +L + + E E +K+ + +Y E + + EL ++ + +
Sbjct: 393 AEKLKSLMASEVDDHHAAIERRNEYNLRKLDE--EYKERIAALKNELRKEREQILQQAGK 450
Query: 179 --LSLNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKER--------- 227
L L Q +EK T YI + ++LK E+ L+ + ++ AE+L E E
Sbjct: 451 QRLELEQEIEKAKTEENYIRDRLA-LSLK-ENSRLENELLENAEKLAEYENLTNKLQRNL 508
Query: 228 ---------------AEYLIRKQELTAQINEFENTREV---------KRMETYQKKKELD 263
AE+ ++++ LT NE+E V +E Y+ + +
Sbjct: 509 ENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVL 568
Query: 264 KLQTKMSKIKETVTVSAAVLSDHNL---EIARLHESIR---YWEQEVSELKKDLAILEAK 317
+L K S +E S + +H L E L+ SI EQ + +D+ L +
Sbjct: 569 RLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLE 628
Query: 318 LCFFTDNKEK-LDDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLS 376
L + EK LD+ K N ++ H + DL+ ++ L Q ++
Sbjct: 629 LEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKE 688
Query: 377 ---------EEEKAFLQ----KQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLIT- 422
EEEK LQ ++K H + + +L + + L+Q + + EGL +
Sbjct: 689 AHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSS 748
Query: 423 ------LQELQQATKTVYQQQIKIL--SANLERESQRCVITQWKMACLRKKHA------- 467
++ L Q + +Q+Q+ L LE+E R + + L++
Sbjct: 749 AWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECN 808
Query: 468 RWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFV 527
R T++I+A+ Q+ +K+ ++ L E +RQ +++ L + +EE+ +
Sbjct: 809 RRTSQIEAQFQSDCQKVTERCESALQSL-EGRYRQ--------ELKDLQEQQREEKSQWE 859
Query: 528 NKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYK--------EKRRKL 579
++ L +E ++ +E+ +KET + +EK LV + ++ E+ YK E+++ L
Sbjct: 860 FEKDELTQECAEAQEL-LKET-LKREKTTSLV-LTQEREMLEKTYKEHLNSMVVERQQLL 916
Query: 580 EELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDV-----------KQELQQLRDQE 628
++L ++ ++ LL++ I R + E+V Q L++L +
Sbjct: 917 QDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEH 976
Query: 629 SKKNKDHFETLKNLENGFYINDQKADLLLLENKKLKEYILYLKNNIEKYREGQEALMHTS 688
++ ++ L +EN + AD E ++ I L++ I++ ++ L
Sbjct: 977 DQERQEMMSKLLAMENIHKATCETAD---RERAEMSTEISRLQSKIKEMQQATSPLSMLQ 1033
Query: 689 NDLSRQLIAQEAQYKD-LWAEFQTTVKILVDNGEETL 724
+ Q+I +E D + Q ++L +NG+ L
Sbjct: 1034 SGC--QVIGEEEVEGDGALSLLQQGEQLLEENGDVLL 1068
Score = 55.8 bits (133), Expect = 2e-07
Identities = 78/416 (18%), Positives = 186/416 (44%), Gaps = 43/416 (10%)
Query: 65 EEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRE-----LEE 119
EE K + D+ + ++++ ++LL ES +L + +L ++ E L+
Sbjct: 1489 EELKAMMHDLQITCSEMQQK----VELLRYESEKLQQENSILRNEITTLNEEDSISNLKL 1544
Query: 120 CVRDARRLNLFE-INTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHAR-- 176
+ + +++ T+K + +E LKK+I++L N+ L + EL++K+++
Sbjct: 1545 GTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQ 1604
Query: 177 -FVLSLNQTM-------EKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKERA 228
+ LNQ + EK+ + K NLK E ++C ++ L+ A
Sbjct: 1605 EKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEE----LERCKVQSSTLVSSLEA 1660
Query: 229 EYLIRKQELTAQINEFEN---TREVKRMETYQKKKELDKLQTKMSKI----------KET 275
E + + ++ I + EN E+++M+ + +L Q K+S + KE
Sbjct: 1661 E--LSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEA 1718
Query: 276 VTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDE 335
++ D + + L I +QE + A L+++L ++EK+ ++ +
Sbjct: 1719 LSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQL---VASQEKVQNLEDTV 1775
Query: 336 KNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQ 395
+N L ++ ++ L + E + L++++ +L +Q + + + NQ++
Sbjct: 1776 QNVNL-QMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQK 1834
Query: 396 LTFISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSANLERESQR 451
+ ++ +++++ + E L T+ + +A T +++++ L +NL + Q+
Sbjct: 1835 RLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQK 1890
Score = 51.2 bits (121), Expect = 4e-06
Identities = 134/658 (20%), Positives = 264/658 (40%), Gaps = 109/658 (16%)
Query: 202 INLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVKRMETYQKKKE 261
INL +AL+ + + + + A + + L +++ Q +E
Sbjct: 337 INLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVD--------------QVVRE 382
Query: 262 LDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHE-SIRYWEQEVSE----LKKDLAILEA 316
+KL++ + K ++ ++ A+ + DH+ I R +E ++R ++E E LK +L E
Sbjct: 383 KEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELR-KER 441
Query: 317 KLCFFTDNKEKLD-------------------DISNDEKNEFLNKIKQLVETLHAARMEY 357
+ K++L+ +S E + N++ + E L EY
Sbjct: 442 EQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKL----AEY 497
Query: 358 KDLREKMK-----TLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVD 412
++L K++ LA ++ + + FLQ++++ Q+ +++ + Q +VD
Sbjct: 498 ENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERL-----TQMRNEYERQCRVLQDQVD 552
Query: 413 --IKNMEEGLITLQELQQATKTVYQQQIKILSANLERE----SQRC-----------VIT 455
+EE + L+ K ++++ S +E E S+ C VI
Sbjct: 553 ELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIE 612
Query: 456 QWK------MACLR---KKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEIS 506
Q K + CLR + R K E +K Q +R E NET +++IS
Sbjct: 613 QMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHE--NETHTLEKQIS 670
Query: 507 GF---VAQIEKLTTELKE--EEKAFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEY 561
+A+++ LKE E ++E+ ++ EE + ++ + E EL
Sbjct: 671 DLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKAR 730
Query: 562 LPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQEL 621
L Q Q + + +E + + QE L H T ++ E++++EL
Sbjct: 731 LTQAQASFEREREGLQSSAWTEEKVRGLTQE--LEQFHQEQLTSLVEKHTLEKEELRKEL 788
Query: 622 QQLRDQESKKNKDHFETLKN-----LENGFYINDQK------ADLLLLENKKLKEYILYL 670
+ +E ++ ++ ET N +E F + QK + L LE + +E L
Sbjct: 789 LEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQE----L 844
Query: 671 KNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTTVKILVDNGEETLQDI-NN 729
K+ E+ RE + ++L+++ + K+ +TT +L E + +
Sbjct: 845 KDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEH 904
Query: 730 LTDKLRERDEKMQHVSTWLRGSLEGLRLLVEQESPMDLLSKQQLRALLVTSKEEKTCQ 787
L + ER + +Q + S LL +Q + K++LR +EE CQ
Sbjct: 905 LNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELR-----EREEVLCQ 957
>gi|148536871 ninein isoform 1 [Homo sapiens]
Length = 2046
Score = 93.6 bits (231), Expect = 7e-19
Identities = 166/744 (22%), Positives = 322/744 (43%), Gaps = 123/744 (16%)
Query: 140 TRTE-----NEIELLKKKITDLTKYNEALGEKQEELARKHARFVLSLNQTMEKKATTTVY 194
TRTE N+I L++++ L + EK+++L F +S+ ++KK
Sbjct: 1189 TRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLL-----FDVSV---LKKKLKMLER 1240
Query: 195 INETYTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVKRME 254
I E K L ED++ + C+QE +ME E L +ELTA++ F E+K+ME
Sbjct: 1241 IPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEV--FRLQDELKKME 1298
Query: 255 TYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAIL 314
E+ + + K + V + L N+ + RL I ++ V + + D +
Sbjct: 1299 ------EVTETFLSLEKSYDEVKIENEEL---NVLVLRLQGKIEKLQESVVQ-RCDCCLW 1348
Query: 315 EAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYK----------DLREKM 364
EA L +N E D + + N+ L + V ++H E K L EK+
Sbjct: 1349 EASL----ENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKV 1404
Query: 365 KT--LARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLIT 422
K +A + + + +E+ +Q Q I +EN L F Q ++F Q + I +E
Sbjct: 1405 KAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGF--QDKHF--QHQATIAELELEKTK 1460
Query: 423 LQELQQATK---TVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKAE-IQ 478
LQEL + K T+ +Q +LS + E + ++ ++ C + + ++E +Q
Sbjct: 1461 LQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQ 1520
Query: 479 AITEKIQNAEVRRIELLNE----TSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLM 534
++N I LNE ++ + ++G ++ + T +K+E A + L
Sbjct: 1521 QENSILRN----EITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLK 1576
Query: 535 KELS----KYEEIFVKETQI------NKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSN 584
K++S K +++ ++ T++ N+EK +EL + L ++ + ++E + LEE
Sbjct: 1577 KQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEM-LCQKEKEPGNSALEE--- 1632
Query: 585 IITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQ---QLRDQESKKNKDHFETLKN 641
+ QE+ L + S +S++E E++ + QE+ KD E +K
Sbjct: 1633 ----REQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQ 1688
Query: 642 LENGFYIND--QKADLLLLENKKL---KEYI--------------LYLKNNIEKYREGQE 682
L ++D QK +L N+KL KE + L++ I ++ Q+
Sbjct: 1689 LHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQK 1748
Query: 683 ALMHTSNDLSRQLIAQEAQYKDL----------WAEFQTTVKILVDNGEETLQDINNLTD 732
+ H S L QL+A + + ++L + ++ +++ E Q++ +L
Sbjct: 1749 SWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHK 1808
Query: 733 KLRERDEK--MQHVSTWLRG--------SLEGLRLLVEQESPMDLLSKQQLRALL----- 777
+L+ K ++T G S + L L+ +E + ++L+ ++
Sbjct: 1809 QLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKA 1868
Query: 778 -VTSKEEKTCQLSDLVIPNYATNI 800
+T EK QL ++P + ++
Sbjct: 1869 ELTHSREKVRQLESNLLPKHQKHL 1892
Score = 80.1 bits (196), Expect = 8e-15
Identities = 155/757 (20%), Positives = 315/757 (41%), Gaps = 120/757 (15%)
Query: 66 EAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPNSI--KRELEECVRD 123
+ I L ++ +A++ + K +I + S + ++ +LLE + + K +L +
Sbjct: 334 DGNINLTELTLALENELLVTKNSIHQAALASFKA-EIRHLLERVDQVVREKEKLRSDLDK 392
Query: 124 ARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFV----- 178
A +L + + E E +K+ + +Y E + + EL ++ + +
Sbjct: 393 AEKLKSLMASEVDDHHAAIERRNEYNLRKLDE--EYKERIAALKNELRKEREQILQQAGK 450
Query: 179 --LSLNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKER--------- 227
L L Q +EK T YI + ++LK E+ L+ + ++ AE+L E E
Sbjct: 451 QRLELEQEIEKAKTEENYIRDRLA-LSLK-ENSRLENELLENAEKLAEYENLTNKLQRNL 508
Query: 228 ---------------AEYLIRKQELTAQINEFENTREV---------KRMETYQKKKELD 263
AE+ ++++ LT NE+E V +E Y+ + +
Sbjct: 509 ENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVL 568
Query: 264 KLQTKMSKIKETVTVSAAVLSDHNL---EIARLHESIR---YWEQEVSELKKDLAILEAK 317
+L K S +E S + +H L E L+ SI EQ + +D+ L +
Sbjct: 569 RLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLE 628
Query: 318 LCFFTDNKEK-LDDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLS 376
L + EK LD+ K N ++ H + DL+ ++ L Q ++
Sbjct: 629 LEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKE 688
Query: 377 ---------EEEKAFLQ----KQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLIT- 422
EEEK LQ ++K H + + +L + + L+Q + + EGL +
Sbjct: 689 AHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSS 748
Query: 423 ------LQELQQATKTVYQQQIKIL--SANLERESQRCVITQWKMACLRKKHA------- 467
++ L Q + +Q+Q+ L LE+E R + + L++
Sbjct: 749 AWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECN 808
Query: 468 RWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFV 527
R T++I+A+ Q+ +K+ ++ L E +RQ +++ L + +EE+ +
Sbjct: 809 RRTSQIEAQFQSDCQKVTERCESALQSL-EGRYRQ--------ELKDLQEQQREEKSQWE 859
Query: 528 NKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYK--------EKRRKL 579
++ L +E ++ +E+ +KET + +EK LV + ++ E+ YK E+++ L
Sbjct: 860 FEKDELTQECAEAQEL-LKET-LKREKTTSLV-LTQEREMLEKTYKEHLNSMVVERQQLL 916
Query: 580 EELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDV-----------KQELQQLRDQE 628
++L ++ ++ LL++ I R + E+V Q L++L +
Sbjct: 917 QDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEH 976
Query: 629 SKKNKDHFETLKNLENGFYINDQKADLLLLENKKLKEYILYLKNNIEKYREGQEALMHTS 688
++ ++ L +EN + AD E ++ I L++ I++ ++ L
Sbjct: 977 DQERQEMMSKLLAMENIHKATCETAD---RERAEMSTEISRLQSKIKEMQQATSPLSMLQ 1033
Query: 689 NDLSRQLIAQEAQYKD-LWAEFQTTVKILVDNGEETL 724
+ Q+I +E D + Q ++L +NG+ L
Sbjct: 1034 SGC--QVIGEEEVEGDGALSLLQQGEQLLEENGDVLL 1068
Score = 55.8 bits (133), Expect = 2e-07
Identities = 78/416 (18%), Positives = 186/416 (44%), Gaps = 43/416 (10%)
Query: 65 EEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRE-----LEE 119
EE K + D+ + ++++ ++LL ES +L + +L ++ E L+
Sbjct: 1489 EELKAMMHDLQITCSEMQQK----VELLRYESEKLQQENSILRNEITTLNEEDSISNLKL 1544
Query: 120 CVRDARRLNLFE-INTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHAR-- 176
+ + +++ T+K + +E LKK+I++L N+ L + EL++K+++
Sbjct: 1545 GTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQ 1604
Query: 177 -FVLSLNQTM-------EKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKERA 228
+ LNQ + EK+ + K NLK E ++C ++ L+ A
Sbjct: 1605 EKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEE----LERCKVQSSTLVSSLEA 1660
Query: 229 EYLIRKQELTAQINEFEN---TREVKRMETYQKKKELDKLQTKMSKI----------KET 275
E + + ++ I + EN E+++M+ + +L Q K+S + KE
Sbjct: 1661 E--LSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEA 1718
Query: 276 VTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDE 335
++ D + + L I +QE + A L+++L ++EK+ ++ +
Sbjct: 1719 LSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQL---VASQEKVQNLEDTV 1775
Query: 336 KNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQ 395
+N L ++ ++ L + E + L++++ +L +Q + + + NQ++
Sbjct: 1776 QNVNL-QMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQK 1834
Query: 396 LTFISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSANLERESQR 451
+ ++ +++++ + E L T+ + +A T +++++ L +NL + Q+
Sbjct: 1835 RLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQK 1890
Score = 51.2 bits (121), Expect = 4e-06
Identities = 134/658 (20%), Positives = 264/658 (40%), Gaps = 109/658 (16%)
Query: 202 INLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVKRMETYQKKKE 261
INL +AL+ + + + + A + + L +++ Q +E
Sbjct: 337 INLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVD--------------QVVRE 382
Query: 262 LDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHE-SIRYWEQEVSE----LKKDLAILEA 316
+KL++ + K ++ ++ A+ + DH+ I R +E ++R ++E E LK +L E
Sbjct: 383 KEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELR-KER 441
Query: 317 KLCFFTDNKEKLD-------------------DISNDEKNEFLNKIKQLVETLHAARMEY 357
+ K++L+ +S E + N++ + E L EY
Sbjct: 442 EQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKL----AEY 497
Query: 358 KDLREKMK-----TLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVD 412
++L K++ LA ++ + + FLQ++++ Q+ +++ + Q +VD
Sbjct: 498 ENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERL-----TQMRNEYERQCRVLQDQVD 552
Query: 413 --IKNMEEGLITLQELQQATKTVYQQQIKILSANLERE----SQRC-----------VIT 455
+EE + L+ K ++++ S +E E S+ C VI
Sbjct: 553 ELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIE 612
Query: 456 QWK------MACLR---KKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEIS 506
Q K + CLR + R K E +K Q +R E NET +++IS
Sbjct: 613 QMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHE--NETHTLEKQIS 670
Query: 507 GF---VAQIEKLTTELKE--EEKAFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEY 561
+A+++ LKE E ++E+ ++ EE + ++ + E EL
Sbjct: 671 DLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKAR 730
Query: 562 LPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQEL 621
L Q Q + + +E + + QE L H T ++ E++++EL
Sbjct: 731 LTQAQASFEREREGLQSSAWTEEKVRGLTQE--LEQFHQEQLTSLVEKHTLEKEELRKEL 788
Query: 622 QQLRDQESKKNKDHFETLKN-----LENGFYINDQK------ADLLLLENKKLKEYILYL 670
+ +E ++ ++ ET N +E F + QK + L LE + +E L
Sbjct: 789 LEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQE----L 844
Query: 671 KNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTTVKILVDNGEETLQDI-NN 729
K+ E+ RE + ++L+++ + K+ +TT +L E + +
Sbjct: 845 KDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEH 904
Query: 730 LTDKLRERDEKMQHVSTWLRGSLEGLRLLVEQESPMDLLSKQQLRALLVTSKEEKTCQ 787
L + ER + +Q + S LL +Q + K++LR +EE CQ
Sbjct: 905 LNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELR-----EREEVLCQ 957
>gi|148536869 ninein isoform 2 [Homo sapiens]
Length = 2133
Score = 93.6 bits (231), Expect = 7e-19
Identities = 166/744 (22%), Positives = 322/744 (43%), Gaps = 123/744 (16%)
Query: 140 TRTE-----NEIELLKKKITDLTKYNEALGEKQEELARKHARFVLSLNQTMEKKATTTVY 194
TRTE N+I L++++ L + EK+++L F +S+ ++KK
Sbjct: 1189 TRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLL-----FDVSV---LKKKLKMLER 1240
Query: 195 INETYTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVKRME 254
I E K L ED++ + C+QE +ME E L +ELTA++ F E+K+ME
Sbjct: 1241 IPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEV--FRLQDELKKME 1298
Query: 255 TYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAIL 314
E+ + + K + V + L N+ + RL I ++ V + + D +
Sbjct: 1299 ------EVTETFLSLEKSYDEVKIENEEL---NVLVLRLQGKIEKLQESVVQ-RCDCCLW 1348
Query: 315 EAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYK----------DLREKM 364
EA L +N E D + + N+ L + V ++H E K L EK+
Sbjct: 1349 EASL----ENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKV 1404
Query: 365 KT--LARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLIT 422
K +A + + + +E+ +Q Q I +EN L F Q ++F Q + I +E
Sbjct: 1405 KAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGF--QDKHF--QHQATIAELELEKTK 1460
Query: 423 LQELQQATK---TVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKAE-IQ 478
LQEL + K T+ +Q +LS + E + ++ ++ C + + ++E +Q
Sbjct: 1461 LQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQ 1520
Query: 479 AITEKIQNAEVRRIELLNE----TSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLM 534
++N I LNE ++ + ++G ++ + T +K+E A + L
Sbjct: 1521 QENSILRN----EITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLK 1576
Query: 535 KELS----KYEEIFVKETQI------NKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSN 584
K++S K +++ ++ T++ N+EK +EL + L ++ + ++E + LEE
Sbjct: 1577 KQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEM-LCQKEKEPGNSALEE--- 1632
Query: 585 IITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQ---QLRDQESKKNKDHFETLKN 641
+ QE+ L + S +S++E E++ + QE+ KD E +K
Sbjct: 1633 ----REQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQ 1688
Query: 642 LENGFYIND--QKADLLLLENKKL---KEYI--------------LYLKNNIEKYREGQE 682
L ++D QK +L N+KL KE + L++ I ++ Q+
Sbjct: 1689 LHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQK 1748
Query: 683 ALMHTSNDLSRQLIAQEAQYKDL----------WAEFQTTVKILVDNGEETLQDINNLTD 732
+ H S L QL+A + + ++L + ++ +++ E Q++ +L
Sbjct: 1749 SWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHK 1808
Query: 733 KLRERDEK--MQHVSTWLRG--------SLEGLRLLVEQESPMDLLSKQQLRALL----- 777
+L+ K ++T G S + L L+ +E + ++L+ ++
Sbjct: 1809 QLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKA 1868
Query: 778 -VTSKEEKTCQLSDLVIPNYATNI 800
+T EK QL ++P + ++
Sbjct: 1869 ELTHSREKVRQLESNLLPKHQKHL 1892
Score = 80.1 bits (196), Expect = 8e-15
Identities = 155/757 (20%), Positives = 315/757 (41%), Gaps = 120/757 (15%)
Query: 66 EAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPNSI--KRELEECVRD 123
+ I L ++ +A++ + K +I + S + ++ +LLE + + K +L +
Sbjct: 334 DGNINLTELTLALENELLVTKNSIHQAALASFKA-EIRHLLERVDQVVREKEKLRSDLDK 392
Query: 124 ARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFV----- 178
A +L + + E E +K+ + +Y E + + EL ++ + +
Sbjct: 393 AEKLKSLMASEVDDHHAAIERRNEYNLRKLDE--EYKERIAALKNELRKEREQILQQAGK 450
Query: 179 --LSLNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKER--------- 227
L L Q +EK T YI + ++LK E+ L+ + ++ AE+L E E
Sbjct: 451 QRLELEQEIEKAKTEENYIRDRLA-LSLK-ENSRLENELLENAEKLAEYENLTNKLQRNL 508
Query: 228 ---------------AEYLIRKQELTAQINEFENTREV---------KRMETYQKKKELD 263
AE+ ++++ LT NE+E V +E Y+ + +
Sbjct: 509 ENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVL 568
Query: 264 KLQTKMSKIKETVTVSAAVLSDHNL---EIARLHESIR---YWEQEVSELKKDLAILEAK 317
+L K S +E S + +H L E L+ SI EQ + +D+ L +
Sbjct: 569 RLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLE 628
Query: 318 LCFFTDNKEK-LDDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLS 376
L + EK LD+ K N ++ H + DL+ ++ L Q ++
Sbjct: 629 LEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKE 688
Query: 377 ---------EEEKAFLQ----KQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLIT- 422
EEEK LQ ++K H + + +L + + L+Q + + EGL +
Sbjct: 689 AHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSS 748
Query: 423 ------LQELQQATKTVYQQQIKIL--SANLERESQRCVITQWKMACLRKKHA------- 467
++ L Q + +Q+Q+ L LE+E R + + L++
Sbjct: 749 AWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECN 808
Query: 468 RWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFV 527
R T++I+A+ Q+ +K+ ++ L E +RQ +++ L + +EE+ +
Sbjct: 809 RRTSQIEAQFQSDCQKVTERCESALQSL-EGRYRQ--------ELKDLQEQQREEKSQWE 859
Query: 528 NKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYK--------EKRRKL 579
++ L +E ++ +E+ +KET + +EK LV + ++ E+ YK E+++ L
Sbjct: 860 FEKDELTQECAEAQEL-LKET-LKREKTTSLV-LTQEREMLEKTYKEHLNSMVVERQQLL 916
Query: 580 EELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDV-----------KQELQQLRDQE 628
++L ++ ++ LL++ I R + E+V Q L++L +
Sbjct: 917 QDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEH 976
Query: 629 SKKNKDHFETLKNLENGFYINDQKADLLLLENKKLKEYILYLKNNIEKYREGQEALMHTS 688
++ ++ L +EN + AD E ++ I L++ I++ ++ L
Sbjct: 977 DQERQEMMSKLLAMENIHKATCETAD---RERAEMSTEISRLQSKIKEMQQATSPLSMLQ 1033
Query: 689 NDLSRQLIAQEAQYKD-LWAEFQTTVKILVDNGEETL 724
+ Q+I +E D + Q ++L +NG+ L
Sbjct: 1034 SGC--QVIGEEEVEGDGALSLLQQGEQLLEENGDVLL 1068
Score = 60.5 bits (145), Expect = 6e-09
Identities = 118/641 (18%), Positives = 253/641 (39%), Gaps = 131/641 (20%)
Query: 65 EEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRE-----LEE 119
EE K + D+ + ++++ ++LL ES +L + +L ++ E L+
Sbjct: 1489 EELKAMMHDLQITCSEMQQK----VELLRYESEKLQQENSILRNEITTLNEEDSISNLKL 1544
Query: 120 CVRDARRLNLFE-INTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHAR-- 176
+ + +++ T+K + +E LKK+I++L N+ L + EL++K+++
Sbjct: 1545 GTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQ 1604
Query: 177 -FVLSLNQTM-------EKKATTTVYINETYTKINLKRE--------------------D 208
+ LNQ + EK+ + K NLK E +
Sbjct: 1605 EKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSE 1664
Query: 209 IALQKKCIQEAEELMEKE--------------------------RAEYLIRKQELTAQIN 242
+ +Q +Q+ L++ E + L K+ L+ ++N
Sbjct: 1665 VKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELN 1724
Query: 243 E----------FENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIAR 292
E+ + E + + L++++ +E V + + NL+++R
Sbjct: 1725 SCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSR 1784
Query: 293 LHESIRYWEQEVSELKKDLAILEAKL-----------------CFFTDNK----EKLDDI 331
+ +R +QE LK+++ L +L K +KLD +
Sbjct: 1785 MKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHL 1844
Query: 332 SNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDE 391
N+E+ + ++L + + E REK++ L +L + +K ++
Sbjct: 1845 MNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESN---LLPKHQKHLNPSGTMNPT 1901
Query: 392 NQKQLTFISQKEYF------LSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSANL 445
Q++L+ + + F ++K + ++E+ L T+ + K ++Q+K+ +
Sbjct: 1902 EQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLK---KKQVKLDEQLM 1958
Query: 446 ERESQRCVIT------QWKMACLRKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETS 499
E + R T W + L+++ + + + ++ AE L E
Sbjct: 1959 EMQHLRSTATPSPSPHAWDLQLLQQQACPMVP--REQFLQLQRQLLQAERINQHLQEELE 2016
Query: 500 FRQQEISGFVAQIEKLTTELKEE----EKAFVNKEKMLMKELSKYEEIFVKETQIN---K 552
R E + E+L T ++E E+ +++L +++++ +E K T+ + K
Sbjct: 2017 NRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQLCKNTKADAMVK 2076
Query: 553 EKEEELVEYLPQLQVAEQEYKEKRRK---LEE----LSNII 586
+ E + L L+V EQ K +K LEE LSNI+
Sbjct: 2077 DLYVENAQLLKALEVTEQRQKTAEKKNYLLEEKIASLSNIV 2117
Score = 51.2 bits (121), Expect = 4e-06
Identities = 134/658 (20%), Positives = 264/658 (40%), Gaps = 109/658 (16%)
Query: 202 INLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVKRMETYQKKKE 261
INL +AL+ + + + + A + + L +++ Q +E
Sbjct: 337 INLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVD--------------QVVRE 382
Query: 262 LDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHE-SIRYWEQEVSE----LKKDLAILEA 316
+KL++ + K ++ ++ A+ + DH+ I R +E ++R ++E E LK +L E
Sbjct: 383 KEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELR-KER 441
Query: 317 KLCFFTDNKEKLD-------------------DISNDEKNEFLNKIKQLVETLHAARMEY 357
+ K++L+ +S E + N++ + E L EY
Sbjct: 442 EQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKL----AEY 497
Query: 358 KDLREKMK-----TLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVD 412
++L K++ LA ++ + + FLQ++++ Q+ +++ + Q +VD
Sbjct: 498 ENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERL-----TQMRNEYERQCRVLQDQVD 552
Query: 413 --IKNMEEGLITLQELQQATKTVYQQQIKILSANLERE----SQRC-----------VIT 455
+EE + L+ K ++++ S +E E S+ C VI
Sbjct: 553 ELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIE 612
Query: 456 QWK------MACLR---KKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEIS 506
Q K + CLR + R K E +K Q +R E NET +++IS
Sbjct: 613 QMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHE--NETHTLEKQIS 670
Query: 507 GF---VAQIEKLTTELKE--EEKAFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEY 561
+A+++ LKE E ++E+ ++ EE + ++ + E EL
Sbjct: 671 DLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKAR 730
Query: 562 LPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQEL 621
L Q Q + + +E + + QE L H T ++ E++++EL
Sbjct: 731 LTQAQASFEREREGLQSSAWTEEKVRGLTQE--LEQFHQEQLTSLVEKHTLEKEELRKEL 788
Query: 622 QQLRDQESKKNKDHFETLKN-----LENGFYINDQK------ADLLLLENKKLKEYILYL 670
+ +E ++ ++ ET N +E F + QK + L LE + +E L
Sbjct: 789 LEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQE----L 844
Query: 671 KNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTTVKILVDNGEETLQDI-NN 729
K+ E+ RE + ++L+++ + K+ +TT +L E + +
Sbjct: 845 KDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEH 904
Query: 730 LTDKLRERDEKMQHVSTWLRGSLEGLRLLVEQESPMDLLSKQQLRALLVTSKEEKTCQ 787
L + ER + +Q + S LL +Q + K++LR +EE CQ
Sbjct: 905 LNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELR-----EREEVLCQ 957
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 92.8 bits (229), Expect = 1e-18
Identities = 151/716 (21%), Positives = 304/716 (42%), Gaps = 81/716 (11%)
Query: 98 ELNKLYYLLETLPNSIKRELEECV--RDARRLNLFEINTIKMRITRTENEIELLKKKITD 155
EL + + T R +EE RDA L L+ NTI + +N K ++ +
Sbjct: 142 ELQRALSAVSTWHKKADRYIEELTKERDALSLELYR-NTITNEELKKKNAELQEKLRLAE 200
Query: 156 LTKYNEALGEKQEELARKHARFVLSLNQT---MEKKATTTVYINETYTKINLKREDIALQ 212
K L K+ + + A+F+L QT E+ + E KI + E + Q
Sbjct: 201 SEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQ 260
Query: 213 KKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVKRMETYQKKKELDKLQTKMSKI 272
++ ++E E M ++ E +R+QE + E E + K + +++K+L + + +M +
Sbjct: 261 EERLREQEGKMREQ--EEKMRRQEKRLREQEKELREQEKEL---REQKKLREQEEQMQEQ 315
Query: 273 KETVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKL--DD 330
+E + + + ++ R E R WEQE K + E K+ D +E++ D
Sbjct: 316 EEKMWEQEEKMREQEEKMWRQEE--RLWEQE-----KQMREQEQKM---RDQEERMWEQD 365
Query: 331 ISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHD 390
EK E + + +++ E + E + +RE+ K + + + + +EEK Q++ + +
Sbjct: 366 ERLREKEERMREQEKMWEQEEKMQEEER-IREREKKMREEEETMREQEEKMQKQEENMWE 424
Query: 391 ENQKQLTFISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSANLERESQ 450
+ +K+ Q+R + +E L +++Q+ + +++Q+ KI +
Sbjct: 425 QEEKEW----------QQQR--LPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQE 472
Query: 451 RCVITQWKMACLRKKHARWTAKIKAEIQAITEKIQNAEVR---RIELLNETSFRQQEISG 507
+ + Q KM ++ W + K Q +K+ + E R + E L E R +E
Sbjct: 473 KKMWRQEKMR--EQEDQMWEQEEKMRDQE--QKMWDQEERMWEQDERLREKEERMREQKK 528
Query: 508 FVAQIEKLTTELKEEEKAFVNKEKML--MKELSKYEEIFVKETQINKEKEEELVEYLPQL 565
Q EK+ EEK +EK +E + EE + + +E+EE + E ++
Sbjct: 529 MWQQEEKM-----REEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKM 583
Query: 566 QVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQQLR 625
Q E++ +E+ K+ E Q QEE + ++ ++ + E++ E ++
Sbjct: 584 QEQEEKMREQEEKMWEQEE--KMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKM 641
Query: 626 DQESKKNKDHFETLKNLENGFYINDQKADLLLLENKKLKEYILYLKNNIEKYREGQEALM 685
++ +K + E ++ E ++K + + +K++E ++ EK RE +E +
Sbjct: 642 QEQEEKMWEQEEKMREQEEKMREQEEK---MQGQEEKMREQEEKMQGQEEKMREQEEKMR 698
Query: 686 HTSNDLSRQLIAQEAQYKDLWAEFQTTVKILVDNGEETLQD-INNLTDKLRERDEK---- 740
+ Q Q + +W + + K EE ++D + ++L E +E+
Sbjct: 699 GQEEKMWGQEEKMWGQEEKMWGQEEMREK------EERIRDQKEKMQERLPEHEERCSEP 752
Query: 741 ----------MQHVSTWLRGSLEGLRLLVEQESPMDLLSKQQLRALLVTSKEEKTC 786
M H GS+E + SP D + Q++ L K + C
Sbjct: 753 CLPPSKVLCNMSHT-----GSVEPAGGEAGEGSPQDNPTAQEIMQLFCGMKNAQQC 803
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 92.4 bits (228), Expect = 2e-18
Identities = 129/653 (19%), Positives = 284/653 (43%), Gaps = 89/653 (13%)
Query: 140 TRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFVLSLNQTMEKKATTTVYINETY 199
T+ E E+ LKK + + TK +EA + +++ ++HA + L++ +E+ + +
Sbjct: 1170 TKREQEVAELKKALEEETKNHEA---QIQDMRQRHATALEELSEQLEQAKRFKANLEKNK 1226
Query: 200 TKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVKRMETYQKK 259
+ +++A + K +Q+ + E +R + + QEL A+++E + R + + +
Sbjct: 1227 QGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQ 1286
Query: 260 KELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLC 319
ELD + T + + E++ + KD A LE++L
Sbjct: 1287 NELDNVSTLLEEA----------------------------EKKGIKFAKDAASLESQL- 1317
Query: 320 FFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLSEEE 379
D +E L + + + N ++I+QL E ++ + + ++ E K L +Q VL+ +
Sbjct: 1318 --QDTQELLQEETRQKLN-LSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQ---VLALQS 1371
Query: 380 KAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIK 439
+ K+K+ D+ + K+ L + +EE + +L++ TK QQ++
Sbjct: 1372 QLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEK-TKNRLQQELD 1430
Query: 440 ILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETS 499
L+ +L+ + Q + L KK ++ ++ AE ++I+ + R E
Sbjct: 1431 DLTVDLDHQRQ-------VASNLEKKQKKFD-QLLAEEKSISARYAEERDRA-----EAE 1477
Query: 500 FRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSKYEEIFVKETQINKEKEEELV 559
R++E + + E E ++ F + K L ++ E++ + + K +
Sbjct: 1478 AREKETKAL--SLARALEEALEAKEEFERQNKQLRADM---EDLMSSKDDVGK----NVH 1528
Query: 560 EYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQ 619
E + EQ+ +E R +LEEL + + A + L ++ F R + ++ +
Sbjct: 1529 ELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNE 1588
Query: 620 E-----LQQLRDQESKKNKDHFE-------------TLKNLENGFYINDQKADLLLLENK 661
E ++Q+R+ E++ + + LK+LE ++ D ++ + +
Sbjct: 1589 EKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLR 1648
Query: 662 KLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTTVKIL--VDN 719
KL+ + + +E+ R ++ + S + ++L + EA+ L E ++ + +
Sbjct: 1649 KLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQ 1708
Query: 720 GEETLQD--INNLTDKLRERDEKMQHVSTWLRGSLEGL-RLLVEQESPMDLLS 769
+ L D N+ + K DEK + L + L L E++S M+LL+
Sbjct: 1709 ERDELADEITNSASGKSALLDEKRR-----LEARIAQLEEELEEEQSNMELLN 1756
Score = 84.3 bits (207), Expect = 4e-16
Identities = 124/670 (18%), Positives = 284/670 (42%), Gaps = 98/670 (14%)
Query: 137 MRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFVLSLNQTMEKKATTTVYIN 196
+++TR E E++ +++ + + + + EE+ RKH Q +E+K
Sbjct: 845 LQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKH-------QQLLEEK-------- 889
Query: 197 ETYTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVKRMETY 256
N+ E + + + EAEE+ RA +KQEL +++ E+ E +
Sbjct: 890 ------NILAEQLQAETELFAEAEEM----RARLAAKKQELEEILHDLESRVEEEEERNQ 939
Query: 257 QKKKELDKLQTKMSKIKETVTVSAAVLSDHNLE-------IARLHESIRYWEQEVSELKK 309
+ E K+Q + ++E + LE I ++ E I E + S+ K
Sbjct: 940 ILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIK 999
Query: 310 DLAILEAKLC----FFTDNKEKLDDIS--NDEKNEFLNKIKQLVETLHAARMEYKDLREK 363
+ ++E ++ + +EK +++ +++ ++ +++ ++ R E + + K
Sbjct: 1000 EKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRK 1059
Query: 364 M----KTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEG 419
+ L Q + ++ ++ LQ K +E Q L + + ++ ++
Sbjct: 1060 LDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQ 1119
Query: 420 LITLQ---ELQQATKTVYQQQIKILSANLE---RESQRCVITQWKMACLRKKHARWTAKI 473
+ LQ E ++A++ ++Q + LS LE E + + T LR K + A++
Sbjct: 1120 IAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAEL 1179
Query: 474 KAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKML 533
K +A+ E+ +N E + ++ + +E+S + Q ++ L++ ++ K L
Sbjct: 1180 K---KALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKEL 1236
Query: 534 MKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQ---EYKEKRRKLE-ELSNIITAQ 589
E+ +++ + K+ + ++ E ++ ++ E EK KL+ EL N+ T
Sbjct: 1237 ACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLL 1296
Query: 590 RQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNLENGFYIN 649
+ E F++ +++E Q+ Q+L +E+++ + ++ LE
Sbjct: 1297 EEAEKK--------GIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEE---- 1344
Query: 650 DQKADLLLLENKKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEF 709
KN++++ +E +E +L +Q++A ++Q D +
Sbjct: 1345 ---------------------KNSLQEQQEEEE---EARKNLEKQVLALQSQLADTKKKV 1380
Query: 710 QT---TVKILVDNGEETLQDINNLTDKLRERD---EKMQHVSTWLRGSLEGLRL-LVEQE 762
T++ L + ++ L+D L+ +L E+ +K++ L+ L+ L + L Q
Sbjct: 1381 DDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQR 1440
Query: 763 SPMDLLSKQQ 772
L K+Q
Sbjct: 1441 QVASNLEKKQ 1450
Score = 51.6 bits (122), Expect = 3e-06
Identities = 66/327 (20%), Positives = 146/327 (44%), Gaps = 52/327 (15%)
Query: 460 ACLRKKHARWT---AKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLT 516
A L+ +H +W K+K +Q +T + + + + ELL + +Q ++ G
Sbjct: 825 AYLKLRHWQWWRVFTKVKPLLQ-VTRQEEELQAKDEELL-KVKEKQTKVEG--------- 873
Query: 517 TELKEEEKAFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKR 576
EL+E E+ K + L++E + E ET++ E EE K+
Sbjct: 874 -ELEEMER----KHQQLLEEKNILAEQLQAETELFAEAEE-----------MRARLAAKK 917
Query: 577 RKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHF 636
++LEE+ + + ++ +EE+ N + + +I ++E +QL ++E + K
Sbjct: 918 QELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLE------EQLDEEEGARQKLQL 971
Query: 637 ETLKNLENGFYINDQKADLLLLENKKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLI 696
E + +A + KK++E IL L++ K+ + ++ + + S QL
Sbjct: 972 EKV----------TAEAKI-----KKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLA 1016
Query: 697 AQEAQYKDLWAEFQTTVKILVDNGEETLQDINNLTDKLRERDEKMQHVSTWLRGSLEGLR 756
+E + K+L A+ + ++++ + EE L+ +L + K+ +T L+ + L+
Sbjct: 1017 EEEEKAKNL-AKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQ 1075
Query: 757 LLVEQESPMDLLSKQQLRALLVTSKEE 783
+++ +++L+ L +E
Sbjct: 1076 AQIDELKLQLAKKEEELQGALARGDDE 1102
Score = 47.4 bits (111), Expect = 6e-05
Identities = 84/421 (19%), Positives = 180/421 (42%), Gaps = 42/421 (9%)
Query: 394 KQLTFISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIK---ILSANLERESQ 450
K L ++++E L K ++ ++E ++ + + +QQ ++ IL+ L+ E++
Sbjct: 842 KPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETE 901
Query: 451 RCVITQWKMACLRKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVA 510
L + A++ A+ Q + E + + E R E Q E A
Sbjct: 902 -----------LFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQA 950
Query: 511 QIEKLTTELKEEEKAFVNKEKMLMKELSKY-------EEIFVKETQINKE-KEEELVEYL 562
I+ L +L EEE A ++K+ +++++ EEI + E Q +K KE++L+E
Sbjct: 951 HIQDLEEQLDEEEGA---RQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDR 1007
Query: 563 P---QLQVAEQEYKEK-----RRKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNM 614
Q+AE+E K K R K E + + + + ++E+ + R +++
Sbjct: 1008 IAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDL 1067
Query: 615 EDVKQELQ----QLRDQESKKNKDHFETLKNLENGFYINDQKADLLLLENKKLKEYILYL 670
+D ELQ +L+ Q +KK ++ L ++ + ++ ++L+ I L
Sbjct: 1068 QDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVV----RELQAQIAEL 1123
Query: 671 KNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTTVKILVDNGEETLQDINNL 730
+ + E + + DLS +L A + + +D ++ +E + L
Sbjct: 1124 QEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKAL 1183
Query: 731 TDKLRERDEKMQHVSTWLRGSLEGLRLLVEQESPMDLLSKQQLRALLVTSKEEKTCQLSD 790
++ + + ++Q + +LE L +EQ + ++ + L T +E C++
Sbjct: 1184 EEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFK-ANLEKNKQGLETDNKELACEVKV 1242
Query: 791 L 791
L
Sbjct: 1243 L 1243
Score = 40.4 bits (93), Expect = 0.007
Identities = 80/389 (20%), Positives = 164/389 (42%), Gaps = 53/389 (13%)
Query: 79 KKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEECVR-------DARRLNLFE 131
+++EEMR ++ LE E LE ++K + E ++ + +RL + +
Sbjct: 1539 QQVEEMR-TQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQ 1597
Query: 132 INTIKMRIT--RTENEIELLKKK-----ITDLTKYNEALGEKQEELARKHARFVLSLNQT 184
+ ++ + R + + + KK + DL EA + ++E+ ++ + +
Sbjct: 1598 VRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDY 1657
Query: 185 MEKKATTTVYINETYTKINLKREDI-ALQKKCIQEAEELMEKERAEYLIRKQ--ELTAQI 241
+ +E + + + + +L+ + +Q EEL ERA ++ EL +I
Sbjct: 1658 QRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEI 1717
Query: 242 NEFENTR-----EVKRMETY--QKKKELDKLQTKMSKI-----KETVTV----------- 278
+ + E +R+E Q ++EL++ Q+ M + K T+ V
Sbjct: 1718 TNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAER 1777
Query: 279 SAAVLSDH-NLEIARLHESIRYWEQEV-----SELKKDLAILEAKLCFFTDNKE---KLD 329
SAA SD+ ++ R ++ ++ QE+ S+ K ++ LEAK+ + E K
Sbjct: 1778 SAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKER 1837
Query: 330 DISNDEKNEFLNKIKQL---VETLHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQ 386
+N K+K++ VE +YK+ EK +Q K L E E+ +
Sbjct: 1838 AAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRAN 1897
Query: 387 KIHDENQKQLTFISQKEYFLSQKRVDIKN 415
+ Q++L ++ LS++ +KN
Sbjct: 1898 ASRRKLQRELDDATEANEGLSREVSTLKN 1926
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 92.0 bits (227), Expect = 2e-18
Identities = 160/679 (23%), Positives = 309/679 (45%), Gaps = 77/679 (11%)
Query: 147 ELLKKKITDLTKYNEALGEKQEELARKHARFVLSLNQTME--KKATTTVYI---NETYTK 201
++++ ++ ++ E + ++EE A+K AR +L L +T KK +++ N T K
Sbjct: 1327 DMIQGVTQEVIRHKEVM-PREEEQAQKKARDMLGLEETQVILKKGKKVIFLEPGNVTMGK 1385
Query: 202 INLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVKRMETYQKKKE 261
K+E+ +K ++ + ++KER I K+E+T + E + + EV+ M T ++K
Sbjct: 1386 EISKKEEKKTFQKSPKQGRKAVQKERKVGKI-KREMTKE--ERDMSEEVEEMATLEEK-- 1440
Query: 262 LDKLQTKMSKIKETVTVSAAVLSDHNLEIARLH-ESIRYWEQEVSELKKDLAILEAKLCF 320
+ K + K+ I+ T + + E ++H E+ + W+ E +K L E KL
Sbjct: 1441 VVKQEGKLVMIERTPSWQDWKKAWD--EWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQ 1498
Query: 321 FTDNKEKLDDISNDEKNEFLNKIKQLVETLHAAR---MEYKDLREKMKTLARQYKIVLSE 377
+ +++ ++K + KQ+ E + +++ +YKD E+ TL + E
Sbjct: 1499 AGEKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKD--EEEVTLEEEVSREGEE 1556
Query: 378 EEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLITLQE--LQQATKTVYQ 435
+E+ ++Q+ H + + + I +K +KR EE + +E L Q + + Q
Sbjct: 1557 KEQQVTEEQR-HIQEEHKWARIHRKRARAEKKRA----QEERKLAQEEEKLAQEERQLAQ 1611
Query: 436 QQIKILSA--NLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAITEKIQNAE----- 488
++ K+ A + ++ + + K A + A+ K+ E + + +K +
Sbjct: 1612 EERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEK 1671
Query: 489 -VRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSK----YEEI 543
R E L + + E+ +AQ EL + E+ +EK L +EL + EE+
Sbjct: 1672 VAREEEKLAKKGGKLAEVKNILAQ---KVEELPQREQNLDWQEKELAQELEELEWDMEEL 1728
Query: 544 FVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHIFLF 603
KE ++N+E E +LVE +L E+ +R KL E T QEE+LL
Sbjct: 1729 SWKEEELNQE-EGKLVEEKKKLAEEEEALAWQREKLSEEE---TKLAQEEELLIQEKEKL 1784
Query: 604 TRDFSRYISNMEDVKQELQQLRDQESK---KNKDHFETLKNLENGFYINDQKADL----- 655
+ + E + ++ +QL +++ K K + +++ L I QK +L
Sbjct: 1785 AQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKK 1844
Query: 656 -LLLENKKL---KEYILYLKNNIEKYREGQEALMHTSNDLS--RQLIAQEAQYKDLWAEF 709
L E +KL KE +LY N E+ ++ L+ N L +++AQ + L E
Sbjct: 1845 NLAQEKEKLAQRKENLLY---NKERLTHSKKQLVQVKNKLGMFNKILAQVEE--KLTQEK 1899
Query: 710 QTTVKILVDNGEETLQDINNLTDKLRERDEKMQHVSTWLRGSLEGLRLLVEQESPMDLLS 769
+T +K + ET + + + D L ++ EK+ + E ++L +E+ +
Sbjct: 1900 ETVIK-KKEKLAETEKKLVQVEDSLAKKQEKL---------AQEKMKLALEKAM---VQG 1946
Query: 770 KQQLRALLVTSKEEKTCQL 788
K++LR L +KEEK L
Sbjct: 1947 KKRLRGELDIAKEEKALNL 1965
Score = 79.0 bits (193), Expect = 2e-14
Identities = 101/467 (21%), Positives = 223/467 (47%), Gaps = 29/467 (6%)
Query: 141 RTENEIELLKKKITDLTKYNEALGEKQEELARKH--ARFVLSLNQTMEKKATTTVYINET 198
+ E E+ L ++ + + + + E+Q + +H AR + +K+A + +
Sbjct: 1539 KDEEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQE 1598
Query: 199 YTKINLKREDIALQKKCIQEA-----EELMEKERAE-YLIRKQELTAQINEFENTREVKR 252
K+ + +A +++ + +A ++ E +AE +K+E AQ E + ++E ++
Sbjct: 1599 EEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGE-KLSQEAEK 1657
Query: 253 METYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLA 312
+ QK+K+L K K+++ +E + L++ +A+ E + EQ + +K+LA
Sbjct: 1658 LA--QKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELA 1715
Query: 313 ILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYK 372
+L + + ++ N E+ + + + K+L E A + + L E+ LA++ +
Sbjct: 1716 QELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEE 1775
Query: 373 IVLSEEEKAFLQKQKIHDENQ---KQLTFISQKEYFLSQKRVD-IKNMEE------GLIT 422
+++ E+EK K+K+ +E + ++ + +K+ L+QKR I +MEE L
Sbjct: 1776 LLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQ 1835
Query: 423 LQELQQATKTVYQQQIKIL--SANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAI 480
+ L Q K + Q++ K+ NL +R ++ ++ ++ K + KI A+++
Sbjct: 1836 KKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKLGMFN-KILAQVEEK 1894
Query: 481 TEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEE---EKAFVNKEKMLMKEL 537
+ + +++ E L ET + ++ +A+ ++ + K + EKA V +K L EL
Sbjct: 1895 LTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGEL 1954
Query: 538 --SKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEEL 582
+K E+ E + E++ LVE L E ++RK+ ++
Sbjct: 1955 DIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQV 2001
Score = 77.0 bits (188), Expect = 7e-14
Identities = 147/764 (19%), Positives = 329/764 (43%), Gaps = 91/764 (11%)
Query: 53 EQSLQSDYFKCNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPNS 112
E++L K ++EA+ + KK E++ + E +L K L + N
Sbjct: 1641 EETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAR--------EEEKLAKKGGKLAEVKNI 1692
Query: 113 IKRELEECVRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELAR 172
+ +++EE + + L+ E + + E ++E L K +L + L E++++LA
Sbjct: 1693 LAQKVEELPQREQNLDWQE-KELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAE 1751
Query: 173 KHARFVLSLNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKERAEYLI 232
+ +L EK + + + + ++E +A K+ + E EE + ++R E LI
Sbjct: 1752 EEE----ALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKR-EQLI 1806
Query: 233 RKQELTAQINEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIAR 292
K+ AQ E R + ME K K + + +++ K+ L+ ++A+
Sbjct: 1807 EKKMKLAQKRE----RWINSMEELTKNKMILYQKKNLAQEKKN-------LAQEKEKLAQ 1855
Query: 293 LHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHA 352
E++ Y ++ ++ KK L ++ KL F ++++ EK + K ++L ET
Sbjct: 1856 RKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKK 1915
Query: 353 ARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVD 412
L +K + LA++ K+ L+ E+ K+++ E +K L KR+
Sbjct: 1916 LVQVEDSLAKKQEKLAQE-KMKLALEKAMVQGKKRLRGELDIAK---EEKALNLEMKRLA 1971
Query: 413 IKNME--EGLITL-----------QELQQATKTVYQQQIKILSANLERESQRCVITQWKM 459
+ M EG TL +++ Q + ++++++ + L E + + + ++
Sbjct: 1972 EEKMRLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEI 2031
Query: 460 ACLRKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTEL 519
A K +T + +Q K+ A + I+ S +++ + ++KLT
Sbjct: 2032 A---KGKLEFTRGQRIFVQG-QRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLT--- 2084
Query: 520 KEEEKAFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKL 579
++E K + +E++ M ++ + +FVKE +++ E+ + L + E ++ EKR +L
Sbjct: 2085 RDERK--LTQEEIKMTKMKR--ALFVKERRLSIEQSK--------LDIKEWDFSEKRSEL 2132
Query: 580 EELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETL 639
+ + R++ L N R + N E+ ++ ++ESK + H E +
Sbjct: 2133 TKDEKKLA--RKQRKLANK---------MRRMINKEE------KMTEEESKLARKHSEVI 2175
Query: 640 KNLENGFYINDQKADLLLLEN----------KKLKEYILYLKNNIEKYREGQEALMHTSN 689
+ E I +++ L K KE + +E E + +
Sbjct: 2176 LDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLD 2235
Query: 690 DLSRQLIAQEAQYKDLWAEFQTTVKILVDNGEETLQDINNLTDKL-RERDEKMQHVSTWL 748
+L +Q + ++ E + + + + EE ++ ++ +E +EK +
Sbjct: 2236 ELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKK 2295
Query: 749 RGSLEGLRLLVEQESPMDLLSKQQLRALLVTSKEEKTCQLSDLV 792
+ ++ + E++ +++S+++ +L +EE++C L + V
Sbjct: 2296 KEEVQEKEEVFEEKE--EIMSEEETESLSDEEEEEESCSLEEEV 2337
Score = 75.1 bits (183), Expect = 2e-13
Identities = 135/675 (20%), Positives = 286/675 (42%), Gaps = 128/675 (18%)
Query: 76 VAVKKLEEM--RKATIDLLEIE-SMELNKLYYLLETLP---NSIKRELEECVRDARRLN- 128
+ +K+EE+ R+ +D E E + EL +L + +E L + +E + V + ++L
Sbjct: 1692 ILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAE 1751
Query: 129 -----LFEINTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFVLSLNQ 183
++ + T+ E ELL ++ L ++ E + E++E L RK + + +
Sbjct: 1752 EEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMK 1811
Query: 184 TMEKKATTTVYINE-TYTKINL-KREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQI 241
+K+ + E T K+ L +++++A +KK + + +E + + + L K+ LT
Sbjct: 1812 LAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSK 1871
Query: 242 NEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWE 301
+ + M K L +++ K+++ KETV L++ ++ ++ +S+ +
Sbjct: 1872 KQLVQVKNKLGMFN----KILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQ 1927
Query: 302 QEVSELKKDLAILEAKLCFFTDNKEKLD---DISNDEKNEFLNKIKQLVE---------- 348
+++++ K LA+ +A + K++L DI+ +EK L ++K+L E
Sbjct: 1928 EKLAQEKMKLALEKAMV----QGKKRLRGELDIAKEEKALNL-EMKRLAEEKMRLVEGKE 1982
Query: 349 TLHAARMEYKDLREKM---------KTLARQYKIVLSEE-------------EKAFLQKQ 386
TL + KM + L+ + KI+L E+ + F + Q
Sbjct: 1983 TLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQ 2042
Query: 387 KIHDENQKQLTFISQKEYFLSQKRVDIKN----MEEGLITLQELQQATKTVYQQQIK--- 439
+I + Q++L S+K L +KR + + + L LQ+L + + + Q++IK
Sbjct: 2043 RIFVQGQRKLAKASRK---LIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTK 2099
Query: 440 ------ILSANLERESQRCVITQW--------------KMACLRKKHARWTAKIKAEIQA 479
+ L E + I +W K+A ++K A ++ + +
Sbjct: 2100 MKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEK 2159
Query: 480 ITEKIQNAEVRRIELL----NETSFRQQEISGFVAQIEKLTTELK--------------- 520
+TE+ + E++ E ++E+ F+ + + E K
Sbjct: 2160 MTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDE 2219
Query: 521 -EEEKAFVNKEKMLMKELSKYEEIF-----------------VKETQINKEKEEELVEYL 562
E E+ F + + L+ EL K E + V+E + +++EEE E
Sbjct: 2220 VESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQ 2279
Query: 563 PQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQ 622
+ + E++ K+K +K EE+ ++E++++ T S E E +
Sbjct: 2280 VEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEE---ETESLSDEEEEEESCSLEEE 2336
Query: 623 QLRDQESKKNKDHFE 637
R++E K + F+
Sbjct: 2337 VDREKEILKKEKQFK 2351
Score = 69.3 bits (168), Expect = 1e-11
Identities = 105/559 (18%), Positives = 258/559 (46%), Gaps = 43/559 (7%)
Query: 113 IKRELEECVRDARRLNLFEINTIK--MRITRTENEIELLKKKITDLTKYNEALGEKQEEL 170
+ +E E+ ++ R+L E + ++IT+ + E+ + K + GEK +
Sbjct: 1595 LAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQE 1654
Query: 171 ARKHARFVLSLNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKERAEY 230
A K A+ L + EK A + + K+ + +A Q+ EEL ++E+
Sbjct: 1655 AEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILA------QKVEELPQREQ-NL 1707
Query: 231 LIRKQELTAQINEFENTREV---KRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHN 287
+++EL ++ E E E K E Q++ +L + + K+++ +E + LS+
Sbjct: 1708 DWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEE 1767
Query: 288 LEIARLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLV 347
++A+ E + ++++++ K+ + E +L + + ++ ++N +++L
Sbjct: 1768 TKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEELT 1827
Query: 348 ETLHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLS 407
+ + K+L ++ K LA++ + + +E K+++ ++KQL + K +
Sbjct: 1828 KN-KMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERL-THSKKQLVQVKNKLGMFN 1885
Query: 408 Q--KRVDIKNMEEGLITLQELQQATKTVYQQQIKILSANLERESQRCVITQWKMACLRKK 465
+ +V+ K +E +++ ++ +T ++++ + +L ++ ++ + K+A L K
Sbjct: 1886 KILAQVEEKLTQEKETVIKKKEKLAET--EKKLVQVEDSLAKKQEKLAQEKMKLA-LEKA 1942
Query: 466 HARWTAKIKAEIQ-AITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEK 524
+ +++ E+ A EK N E++R L E R E +++ E T E + K
Sbjct: 1943 MVQGKKRLRGELDIAKEEKALNLEMKR---LAEEKMRLVEGKETLSKGE--TPETSRQRK 1997
Query: 525 AFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSN 584
++++ ++LS E+I + E +I +E E+ + + ++ + + +RKL + S
Sbjct: 1998 MTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASR 2057
Query: 585 IITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNLEN 644
+ +R+ S+ + + + + LQ+L E K ++ + K ++
Sbjct: 2058 KLIKKRE--------------SLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTK-MKR 2102
Query: 645 GFYINDQKADLLLLENKKL 663
++ +++ L +E KL
Sbjct: 2103 ALFVKERR---LSIEQSKL 2118
Score = 59.3 bits (142), Expect = 1e-08
Identities = 104/551 (18%), Positives = 240/551 (43%), Gaps = 88/551 (15%)
Query: 72 KDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEECVRDARRLNLFE 131
K I K L + +K E + L Y E L +S K + V+ +L +F
Sbjct: 1830 KMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKK----QLVQVKNKLGMFN 1885
Query: 132 --INTIKMRITRTENEIELLKKKITD----LTKYNEALGEKQEELARKHARFVLSLNQTM 185
+ ++ ++T+ + + K+K+ + L + ++L +KQE+LA++ + L
Sbjct: 1886 KILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQ 1945
Query: 186 EKKATT-TVYINETYTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQINE- 243
KK + I + +NL+ + +A +K + E +E + K R++++T E
Sbjct: 1946 GKKRLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQEL 2005
Query: 244 FENTREVKR-----------MET-----------------YQKKKELDKLQTKMSKIKET 275
FE ++ ME Q +++L K K+ K +E+
Sbjct: 2006 FERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRES 2065
Query: 276 VTVSAAVLSDHNLEIARLHESIRYWEQE---VSELKKDLAILEAKLCFFT--------DN 324
++ A L+ + +L R QE ++++K+ L + E +L D
Sbjct: 2066 LSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEWDF 2125
Query: 325 KEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQY-KIVLSEEEKAFL 383
EK +++ DEK + K ++L + + + + E+ LAR++ +++L +EE+ +
Sbjct: 2126 SEKRSELTKDEK-KLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGI 2184
Query: 384 QKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSA 443
+++++ + F+ ++ + + K E+ + E++ ++ + ++++ L
Sbjct: 2185 EEEEV-------IPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVE--SEEHFSEEMESLLD 2235
Query: 444 NLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQ 503
LE++ ++ + ++ R +++ E + E+ + E +++E E +++
Sbjct: 2236 ELEKQES---LSSEEEEEREEEEEREEEEVREEEEERKEE-EEGEEKQVEKEEEEKKKKK 2291
Query: 504 EISGFVAQIEKLTTELKEEEKAFVNKEKMLMKE--------------LSKYEEIFVKETQ 549
+ EK E++E+E+ F KE+++ +E S EE+ ++
Sbjct: 2292 K--------EKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDREKEI 2343
Query: 550 INKEKEEELVE 560
+ KEK+ +L E
Sbjct: 2344 LKKEKQFKLQE 2354
Score = 40.0 bits (92), Expect = 0.009
Identities = 66/331 (19%), Positives = 130/331 (39%), Gaps = 76/331 (22%)
Query: 34 PSTLGSSVAVEALEQLFVVEQSLQSDYFKCNEEAKIFLKDIAVAVKKLEEMRKATIDL-- 91
P T + ++LF + SL+ +E+ + +++ +A KLE R I +
Sbjct: 1990 PETSRQRKMTQVEQELFERKLSLEEKIL-LHEDRILAMEESEIAKGKLEFTRGQRIFVQG 2048
Query: 92 ---LEIESMELNKLYYLLETLP---NSIKRELEECVRDARRLNLFEINTIKMR------- 138
L S +L K L P N I + L++ RD R+L EI KM+
Sbjct: 2049 QRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKE 2108
Query: 139 -----------------------ITRTENEIELLKKKITD----LTKYNEALGEKQEELA 171
+T+ E ++ ++K+ + + E + E++ +LA
Sbjct: 2109 RRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLA 2168
Query: 172 RKHARFVLS---------------LNQTMEK----------KATTTVYINETYTKINLKR 206
RKH+ +L L + K K + ++E ++ +
Sbjct: 2169 RKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSE 2228
Query: 207 E------DIALQKKCIQEAEELMEKE--RAEYLIRKQELTAQINEFENTREVKRMETYQK 258
E ++ Q+ E EE E+E R E +R++E + E ++V++ E +K
Sbjct: 2229 EMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKK 2288
Query: 259 KKELDKLQTKMSKIKETVTVSAAVLSDHNLE 289
KK+ +K + ++ + +E ++S+ E
Sbjct: 2289 KKKKEKKKEEVQEKEEVFEEKEEIMSEEETE 2319
Score = 30.8 bits (68), Expect = 5.4
Identities = 30/128 (23%), Positives = 58/128 (45%), Gaps = 4/128 (3%)
Query: 144 NEIELLKKKITDLTKYNEALGEKQEELARKHARFVLSLNQTMEKKATTTVYINETYTKIN 203
+E+E + ++ + E E++EE R+ + E+K + K
Sbjct: 2235 DELEKQESLSSEEEEEREEEEEREEEEVREEEE-ERKEEEEGEEKQVEKEEEEKKKKKKE 2293
Query: 204 LKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVKRMETYQKKKELD 263
K+E++ +++ +E EE+M +E E L ++E + E EV R + KK++
Sbjct: 2294 KKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEE---EVDREKEILKKEKQF 2350
Query: 264 KLQTKMSK 271
KLQ + K
Sbjct: 2351 KLQEQRRK 2358
>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo
sapiens]
Length = 1116
Score = 91.7 bits (226), Expect = 3e-18
Identities = 160/727 (22%), Positives = 290/727 (39%), Gaps = 128/727 (17%)
Query: 71 LKDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEECVRDARRLNLF 130
L+ ++ K EE + T L E E M ++ L LLE ++E E + F
Sbjct: 316 LQSKGLSAKATEEDHERTRRLAEAE-MHVHHLESLLE------QKEKENSMLREEMHRRF 368
Query: 131 EINTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFVLSLNQTMEKKAT 190
E + + IE+ KI+ + + L + +EE+ + LS + E+
Sbjct: 369 ENAPDSAKTKALQTVIEMKDSKISSMER---GLRDLEEEIQMLKSNGALSTEEREEEMKQ 425
Query: 191 TTVYINETYTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREV 250
VY +++K ++ K Q EEL KE AQ E +
Sbjct: 426 MEVY--RSHSKF--------MKNKVEQLKEELSSKE------------AQWEELKKKAAG 463
Query: 251 KRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKD 310
+ E Q K+EL + T++ ++ + SD I L ES+ EQ + L+ +
Sbjct: 464 LQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTE 523
Query: 311 LAI----LEAKLCFFTDNKEKLDDISND--------------------EKNEFLNKIKQL 346
+ LE K +++ D++ + + N KI+ L
Sbjct: 524 VDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENL 583
Query: 347 VETLHAARMEYKDLREKMKTLARQ----------YKIVLSEEEKAF--LQKQKIHDENQK 394
E L + L+E++K+L + L+E+E+ L++Q+ DE +K
Sbjct: 584 QEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREK 643
Query: 395 QLTFISQKEYF------LSQKRVDIKNMEEGLITLQELQQATKT---VYQQQIKILSANL 445
Q + K+ +S + D+ E L+ L+E + + ++K L L
Sbjct: 644 QEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIAL 703
Query: 446 ERESQRCVITQWKMACLRKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEI 505
E++ + C+ KM KK + +A + ++++IQ+ E +E+S Q E+
Sbjct: 704 EQKKEECL----KMESQLKKAHEAALEARASPE-MSDRIQHLEREITRYKDESSKAQAEV 758
Query: 506 SGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYL--- 562
+ ++++ E +++K E+ + + K + KE Q+ K+K +++E
Sbjct: 759 DRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKE-QVEKKKSAQMLEEARRR 817
Query: 563 -PQLQVAEQEYKEKRRK----LEELSNI------ITAQR-----QEEDLLNNHIFLFTRD 606
L + Q+ ++ RK +EEL ITA+R QEE N +
Sbjct: 818 EDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTN----AEKQ 873
Query: 607 FSRYISNMEDVKQEL-----------QQLRDQESKKNKDHFETLKNLENGFYINDQKADL 655
+ ME VKQEL Q L ++E+ E K+LE + Q+A L
Sbjct: 874 VEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMK-QEALL 932
Query: 656 LLLENKKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTTVKI 715
+ K +L L ++ +K +E AL + L +QL Q Q +K+
Sbjct: 933 AAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQT----------QNRMKL 982
Query: 716 LVDNGEE 722
+ DN E+
Sbjct: 983 MADNYED 989
Score = 78.6 bits (192), Expect = 2e-14
Identities = 135/676 (19%), Positives = 279/676 (41%), Gaps = 132/676 (19%)
Query: 181 LNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQ 240
L+ E++A + +T ++ L+ I QK+ + +E ++K +++ + L+A+
Sbjct: 270 LHAEHERQAKELFLLRKTLEEMELR---IETQKQTLNARDESIKKLLE--MLQSKGLSAK 324
Query: 241 INE--FENTREVKRMETY---------QKKKELDKLQTKMSKIKETVTVSA------AVL 283
E E TR + E + QK+KE L+ +M + E SA V+
Sbjct: 325 ATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVI 384
Query: 284 SDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKI 343
+ +I+ + +R E+E+ LK + A+ + + + K ++ NK+
Sbjct: 385 EMKDSKISSMERGLRDLEEEIQMLKSNGALSTEE----REEEMKQMEVYRSHSKFMKNKV 440
Query: 344 KQLVETLHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKE 403
+QL E L + ++++L++K L + I Q +
Sbjct: 441 EQLKEELSSKEAQWEELKKKAAGLQAE----------------------------IGQVK 472
Query: 404 YFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSANLERESQRCVITQWKMACLR 463
LS+K ++ ++ L TL +K Q I++L +L + QR I Q ++ LR
Sbjct: 473 QELSRKDTELLALQTKLETLTNQFSDSK----QHIEVLKESLTAKEQRAAILQTEVDALR 528
Query: 464 ----KKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTEL 519
+K K K +IQ + E+ +L + ++++++ +IE L +L
Sbjct: 529 LRLEEKETMLNKKTK-QIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQL 587
Query: 520 KEEEK---AFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKR 576
+++EK + + K L + + + + EKE + ++ EQ +++R
Sbjct: 588 RDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIE------RLKEQRDRDER 641
Query: 577 RKLEELSNIITAQRQEEDL--LNNHIFLFTRDFSRYISNMEDVKQELQQLRDQESKKNKD 634
K EE+ N ++DL L + L D S +++ D+K+ L KK+
Sbjct: 642 EKQEEIDNY------KKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDS- 694
Query: 635 HFETLKNLENGFYINDQKADLLLLENK---------------KLKEYILYLKNNIEKYRE 679
LK LE + +K + L +E++ ++ + I +L+ I +Y++
Sbjct: 695 ---RLKTLE--IALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKD 749
Query: 680 GQ--------------EALMHTSNDLSRQLIAQEAQYKD-------LWAEFQTTVKILVD 718
+ + + ND +++ E Q KD L + Q K
Sbjct: 750 ESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQ 809
Query: 719 NGEETLQDINNLTDKL-------RERDEKMQHVSTWLRGSLE---GLRLLVEQESPMDLL 768
EE + +NL D R++D++++ + LR S++ +++ QE
Sbjct: 810 MLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTN 869
Query: 769 SKQQLRALLVTSKEEK 784
+++Q+ LL+ ++ K
Sbjct: 870 AEKQVEELLMAMEKVK 885
Score = 52.0 bits (123), Expect = 2e-06
Identities = 119/540 (22%), Positives = 221/540 (40%), Gaps = 77/540 (14%)
Query: 278 VSAAVLSDHNLEIAR------LHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDI 331
VS A H+L AR L ++ +E L+KD+ + E+KL
Sbjct: 133 VSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKL------------- 179
Query: 332 SNDEKNEFLNKIKQLVET-LHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHD 390
+ +N IK L R KD K+ QY++V E + + Q + D
Sbjct: 180 -----SSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQD 234
Query: 391 E--NQKQLTFISQKEYFLSQKRVDIKNM-EEGLITL--------QELQQATKTVYQQQIK 439
E Q+ L + Q++ + + EE L +EL KT+ + +++
Sbjct: 235 ELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELR 294
Query: 440 I----LSANLERESQRCVITQWKMACLRKK-----HARWTAKIKAEIQA-ITEKIQNAEV 489
I + N ES + ++ + L K H R +AE+ E + +
Sbjct: 295 IETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKE 354
Query: 490 RRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSKYEEIFVKETQ 549
+ +L E R+ E + A+ + L T ++ ++ + E+ L ++L + ++
Sbjct: 355 KENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGL-RDLEEEIQMLKSNGA 413
Query: 550 INKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITA-QRQEEDL------LNNHIFL 602
++ E+ E E + Q++V K + K+E+L +++ + Q E+L L I
Sbjct: 414 LSTEERE---EEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQ 470
Query: 603 FTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNLENGFYINDQKADLLLLENKK 662
++ SR + + ++ +L+ L +Q S +K H E LK +Q+A +L E
Sbjct: 471 VKQELSRKDTELLALQTKLETLTNQFS-DSKQHIEVLK---ESLTAKEQRAAILQTEVDA 526
Query: 663 L------KEYILYLK-NNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTTVKI 715
L KE +L K I+ E + +DL L +E + L +
Sbjct: 527 LRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKK------- 579
Query: 716 LVDNGEETLQDINNLTDKLRERDEKMQHVSTWLRGSLEGL-RLLVEQESPMDLLSKQQLR 774
++N +E L+D L+ER + +Q +T +L L L E+E ++ L +Q+ R
Sbjct: 580 -IENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDR 638
>gi|118498356 kinectin 1 isoform a [Homo sapiens]
Length = 1357
Score = 90.5 bits (223), Expect = 6e-18
Identities = 157/791 (19%), Positives = 327/791 (41%), Gaps = 146/791 (18%)
Query: 44 EALEQLFVVEQSLQSDYFK--CNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNK 101
+ LEQ ++ +Q + + A + +++ + + ++ K T D L E L
Sbjct: 573 DILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTS 632
Query: 102 LYYLLETLPNS---IKRELE--ECVRDARRLNLFEINTIKMRITRTENEIELLKKKITDL 156
L+ + N +K E++ + + + + E+ ++ + +++I LL++++
Sbjct: 633 KEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQL--- 689
Query: 157 TKYNEALGEKQEELARKHARFVLSLNQTMEKKATTTVYINETYTKINLKREDIALQKKCI 216
Q E++ K F + +Q K + V +T ++ + +KCI
Sbjct: 690 ----------QHEISNKMEEFKILNDQN--KALKSEVQKLQTLVSEQPNKDVVEQMEKCI 737
Query: 217 QE-------AEELMEKERAEYLIRKQELTAQINEFEN-TREVKRMETYQKKK-------- 260
QE EEL+E + +++EL A E + T+EV+ ++ Q +
Sbjct: 738 QEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVE 797
Query: 261 ELDK-LQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLC 319
EL K + K KIK + A L L++A ++++ +QE+ LK+++ ++ +
Sbjct: 798 ELKKVIHEKDGKIKSVEELLEAEL----LKVANKEKTVQDLKQEIKALKEEIGNVQLEKA 853
Query: 320 FFTDNKEKLDDISN--DEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLSE 377
K+ ++ N K E +N +K ++E + KDL K L + + E
Sbjct: 854 QQLSITSKVQELQNLLKGKEEQMNTMKAVLEE------KEKDLANTGKWL----QDLQEE 903
Query: 378 EEKAFLQKQKIHDENQKQLTFISQ---KEYFLSQKRVDIKNMEEGLITLQELQQATKTVY 434
E Q++ N K+ + SQ E L +K ++K +E ++ +E ++KT
Sbjct: 904 NESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLE-AMLKERESDLSSKTQL 962
Query: 435 QQQI----KILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAITEKIQNAEVR 490
Q + K+ + +E+ Q+ ++ A H
Sbjct: 963 LQDVQDENKLFKSQIEQLKQQ----NYQQASSFPPHE----------------------- 995
Query: 491 RIELLNETSFRQQEISGFVAQIEKLTTELKEEEK--------------AFVNKEKMLMKE 536
ELL S R++EISG +++ L ++ + K A + EKML +
Sbjct: 996 --ELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDK 1053
Query: 537 LSKYEEIFVKETQ-INKEKEEELVEYLPQLQVAEQ--------EYKEKRRKL------EE 581
++K + ++ + + E +E L + P++ V +++K ++ E
Sbjct: 1054 VNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSE 1113
Query: 582 LSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQQLRDQESKKNK----DHFE 637
++ + +E D ++ + L + ++ E + Q+LQ+ +QE K K + +
Sbjct: 1114 EVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHK 1173
Query: 638 TLKNLENGFYINDQKADLLLLENKKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIA 697
T+K +++ F ++Q+ + L ENK ++ N+ + RE E + + +
Sbjct: 1174 TIKQMQSSFTSSEQELERLRSENKDIE--------NLRREREHLEMELEKAEMERSTYVT 1225
Query: 698 QEAQYKDLWAEFQTTVKILVDNGEETLQ----------DINNLTDKLRERDEKMQHVSTW 747
+ + KDL E Q K L D+ E ++ +N KLR + Q V+
Sbjct: 1226 EVRELKDLLTELQ---KKLDDSYSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKVAGD 1282
Query: 748 LRGSLEGLRLL 758
L + + L L+
Sbjct: 1283 LHKAQQSLELI 1293
Score = 73.9 bits (180), Expect = 6e-13
Identities = 144/714 (20%), Positives = 301/714 (42%), Gaps = 109/714 (15%)
Query: 65 EEAKIFLKDIAVAVKKL---EEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEECV 121
E A++ KD +++K + E+ +DLL+ +S + + L S K EL +
Sbjct: 278 ENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQ------DALKKSSKGELTTLI 331
Query: 122 RDARRLNLFEINTIKMRITRTENEIELLKKKITD--------LTKYNEALGEKQEELARK 173
+ + + +K T++ + L +++ +T+ + +G ++E
Sbjct: 332 HQLQEKDKL-LAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVF 390
Query: 174 HARFVLSLNQTMEKKATTTVYINETYTKI-NLKREDIALQKKCIQEAEELMEKERAEYLI 232
+ +S +T + + + +I +LK+E+ L+ +L K+ AE
Sbjct: 391 QNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNK 450
Query: 233 RKQELTAQINEF-ENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIA 291
+Q+ +NE E T ++++ E +K E Q K+
Sbjct: 451 LRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKV---------------------- 488
Query: 292 RLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLH 351
+L E+ R WE+ S ++K A EA ++ L ++NE + +L +TL
Sbjct: 489 QLQEAERRWEEVQSYIRKRTAEHEAA-------QQDLQSKFVAKENEVQSLHSKLTDTL- 540
Query: 352 AARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRV 411
+ + L +++ L + +++EE +Q Q I ++N+ +Q + F SQ
Sbjct: 541 ---VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNE---ALKAQIQQFHSQ--- 591
Query: 412 DIKNMEEGLITLQELQQATKTVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTA 471
I + +EL + +QIK +L E R + ++ ++ + A
Sbjct: 592 -IAAQTSASVLAEELHKVI-AEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKA 649
Query: 472 KIKAEIQAITEKIQNAEVRRIELLNETSF-RQQEISGFVAQIEKLTTELKEEEKAFVNKE 530
+++ ++QA+ + Q A +E + ++ + + +I Q++ + EE K ++
Sbjct: 650 EVQ-KLQALANE-QAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQN 707
Query: 531 KMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEEL--SNIITA 588
K L E+ K +T ++++ +++VE Q++ QE EK + +EEL + +I
Sbjct: 708 KALKSEVQKL------QTLVSEQPNKDVVE---QMEKCIQEKDEKLKTVEELLETGLIQV 758
Query: 589 QRQEEDLLNNHIFLFTRDFSRYISNME----------DVKQELQQLRDQESKKNKDHFET 638
+EE+L N I ++ + +++ + +EL+++ ++ K K E
Sbjct: 759 ATKEEEL--NAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEEL 816
Query: 639 LKNLENGFYINDQKADLLLLENKK-----LKEYILYLK---NNIEKYREGQEALMHTSND 690
L +A+LL + NK+ LK+ I LK N++ + Q ++ +
Sbjct: 817 L------------EAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQE 864
Query: 691 LSRQLIAQEAQYKDLWAEFQTTVKILVDNGEETLQDINNLTDKLRER-DEKMQH 743
L L +E Q + A + K L + G + LQD+ + L+ E QH
Sbjct: 865 LQNLLKGKEEQMNTMKAVLEEKEKDLANTG-KWLQDLQEENESLKAHVQEVAQH 917
Score = 58.2 bits (139), Expect = 3e-08
Identities = 117/612 (19%), Positives = 253/612 (41%), Gaps = 90/612 (14%)
Query: 52 VEQSLQSDYFKCNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPN 111
VE+ L+++ K + K ++D+ +K L+E EI +++L K L T
Sbjct: 813 VEELLEAELLKVANKEKT-VQDLKQEIKALKE---------EIGNVQLEKAQQLSIT--- 859
Query: 112 SIKRELEECVRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELA 171
S +EL+ ++ ++NT+K + E ++ K + DL + NE+L +E+A
Sbjct: 860 SKVQELQNLLKGKEE----QMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVA 915
Query: 172 RKHARFVLSLNQTMEKKATTTVYINE---TYTKINLKREDIALQKKCIQEAEELMEKERA 228
+ + + S +Q E + NE + + D++ + + +Q+ ++ + ++
Sbjct: 916 QHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKS 975
Query: 229 EYLIRKQELTAQINEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNL 288
+ KQ+ Q + F E+ ++ + +++KE+ L ++ +K+ V +D
Sbjct: 976 QIEQLKQQNYQQASSFPPHEELLKVIS-EREKEISGLWNELDSLKDAVEHQRKKNND--- 1031
Query: 289 EIARLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLV- 347
L E + WE + L +L+ K+ + +++ + E E L K+ V
Sbjct: 1032 ----LRE--KNWE-AMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVS 1084
Query: 348 --------ETLHAARMEYKDL------REKMKTLARQYKIVLSEEEKAFLQKQKIHDENQ 393
E LH + K+ E++K L ++K+ ++E LQ E +
Sbjct: 1085 VPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVL--EHKLKEADEMHTLLQL-----ECE 1137
Query: 394 KQLTFISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSANLERESQRCV 453
K + +++ E L + + ++ E ++ ++ KT+ Q Q S+ E E
Sbjct: 1138 KYKSVLAETEGILQKLQRSVEQEENKWKV--KVDESHKTIKQMQSSFTSSEQELE----- 1190
Query: 454 ITQWKMACLRKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIE 513
+++ + I+N R L E + E S +V ++
Sbjct: 1191 ----------------------RLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVR 1228
Query: 514 KLTTELKEEEKAFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYK 573
+L L E +K + + + + EE+ + + Q+N+ + E + +VA +K
Sbjct: 1229 ELKDLLTELQKKL---DDSYSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKVAGDLHK 1285
Query: 574 EKRRKLEELSNIITAQRQEEDLLNNHIFLFTRD-----FSRYISNMEDVKQELQQLRDQE 628
++ S I+ A + N+ + T S ++ Q+L Q +Q+
Sbjct: 1286 AQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQ 1345
Query: 629 SKKNKDHFETLK 640
K K+H++ L+
Sbjct: 1346 LTKEKEHYQVLE 1357
>gi|33620775 kinectin 1 isoform a [Homo sapiens]
Length = 1357
Score = 90.5 bits (223), Expect = 6e-18
Identities = 157/791 (19%), Positives = 327/791 (41%), Gaps = 146/791 (18%)
Query: 44 EALEQLFVVEQSLQSDYFK--CNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNK 101
+ LEQ ++ +Q + + A + +++ + + ++ K T D L E L
Sbjct: 573 DILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTS 632
Query: 102 LYYLLETLPNS---IKRELE--ECVRDARRLNLFEINTIKMRITRTENEIELLKKKITDL 156
L+ + N +K E++ + + + + E+ ++ + +++I LL++++
Sbjct: 633 KEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQL--- 689
Query: 157 TKYNEALGEKQEELARKHARFVLSLNQTMEKKATTTVYINETYTKINLKREDIALQKKCI 216
Q E++ K F + +Q K + V +T ++ + +KCI
Sbjct: 690 ----------QHEISNKMEEFKILNDQN--KALKSEVQKLQTLVSEQPNKDVVEQMEKCI 737
Query: 217 QE-------AEELMEKERAEYLIRKQELTAQINEFEN-TREVKRMETYQKKK-------- 260
QE EEL+E + +++EL A E + T+EV+ ++ Q +
Sbjct: 738 QEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVE 797
Query: 261 ELDK-LQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLC 319
EL K + K KIK + A L L++A ++++ +QE+ LK+++ ++ +
Sbjct: 798 ELKKVIHEKDGKIKSVEELLEAEL----LKVANKEKTVQDLKQEIKALKEEIGNVQLEKA 853
Query: 320 FFTDNKEKLDDISN--DEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLSE 377
K+ ++ N K E +N +K ++E + KDL K L + + E
Sbjct: 854 QQLSITSKVQELQNLLKGKEEQMNTMKAVLEE------KEKDLANTGKWL----QDLQEE 903
Query: 378 EEKAFLQKQKIHDENQKQLTFISQ---KEYFLSQKRVDIKNMEEGLITLQELQQATKTVY 434
E Q++ N K+ + SQ E L +K ++K +E ++ +E ++KT
Sbjct: 904 NESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLE-AMLKERESDLSSKTQL 962
Query: 435 QQQI----KILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAITEKIQNAEVR 490
Q + K+ + +E+ Q+ ++ A H
Sbjct: 963 LQDVQDENKLFKSQIEQLKQQ----NYQQASSFPPHE----------------------- 995
Query: 491 RIELLNETSFRQQEISGFVAQIEKLTTELKEEEK--------------AFVNKEKMLMKE 536
ELL S R++EISG +++ L ++ + K A + EKML +
Sbjct: 996 --ELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDK 1053
Query: 537 LSKYEEIFVKETQ-INKEKEEELVEYLPQLQVAEQ--------EYKEKRRKL------EE 581
++K + ++ + + E +E L + P++ V +++K ++ E
Sbjct: 1054 VNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSE 1113
Query: 582 LSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQQLRDQESKKNK----DHFE 637
++ + +E D ++ + L + ++ E + Q+LQ+ +QE K K + +
Sbjct: 1114 EVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHK 1173
Query: 638 TLKNLENGFYINDQKADLLLLENKKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIA 697
T+K +++ F ++Q+ + L ENK ++ N+ + RE E + + +
Sbjct: 1174 TIKQMQSSFTSSEQELERLRSENKDIE--------NLRREREHLEMELEKAEMERSTYVT 1225
Query: 698 QEAQYKDLWAEFQTTVKILVDNGEETLQ----------DINNLTDKLRERDEKMQHVSTW 747
+ + KDL E Q K L D+ E ++ +N KLR + Q V+
Sbjct: 1226 EVRELKDLLTELQ---KKLDDSYSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKVAGD 1282
Query: 748 LRGSLEGLRLL 758
L + + L L+
Sbjct: 1283 LHKAQQSLELI 1293
Score = 73.9 bits (180), Expect = 6e-13
Identities = 144/714 (20%), Positives = 301/714 (42%), Gaps = 109/714 (15%)
Query: 65 EEAKIFLKDIAVAVKKL---EEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEECV 121
E A++ KD +++K + E+ +DLL+ +S + + L S K EL +
Sbjct: 278 ENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQ------DALKKSSKGELTTLI 331
Query: 122 RDARRLNLFEINTIKMRITRTENEIELLKKKITD--------LTKYNEALGEKQEELARK 173
+ + + +K T++ + L +++ +T+ + +G ++E
Sbjct: 332 HQLQEKDKL-LAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVF 390
Query: 174 HARFVLSLNQTMEKKATTTVYINETYTKI-NLKREDIALQKKCIQEAEELMEKERAEYLI 232
+ +S +T + + + +I +LK+E+ L+ +L K+ AE
Sbjct: 391 QNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNK 450
Query: 233 RKQELTAQINEF-ENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIA 291
+Q+ +NE E T ++++ E +K E Q K+
Sbjct: 451 LRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKV---------------------- 488
Query: 292 RLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLH 351
+L E+ R WE+ S ++K A EA ++ L ++NE + +L +TL
Sbjct: 489 QLQEAERRWEEVQSYIRKRTAEHEAA-------QQDLQSKFVAKENEVQSLHSKLTDTL- 540
Query: 352 AARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRV 411
+ + L +++ L + +++EE +Q Q I ++N+ +Q + F SQ
Sbjct: 541 ---VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNE---ALKAQIQQFHSQ--- 591
Query: 412 DIKNMEEGLITLQELQQATKTVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTA 471
I + +EL + +QIK +L E R + ++ ++ + A
Sbjct: 592 -IAAQTSASVLAEELHKVI-AEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKA 649
Query: 472 KIKAEIQAITEKIQNAEVRRIELLNETSF-RQQEISGFVAQIEKLTTELKEEEKAFVNKE 530
+++ ++QA+ + Q A +E + ++ + + +I Q++ + EE K ++
Sbjct: 650 EVQ-KLQALANE-QAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQN 707
Query: 531 KMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEEL--SNIITA 588
K L E+ K +T ++++ +++VE Q++ QE EK + +EEL + +I
Sbjct: 708 KALKSEVQKL------QTLVSEQPNKDVVE---QMEKCIQEKDEKLKTVEELLETGLIQV 758
Query: 589 QRQEEDLLNNHIFLFTRDFSRYISNME----------DVKQELQQLRDQESKKNKDHFET 638
+EE+L N I ++ + +++ + +EL+++ ++ K K E
Sbjct: 759 ATKEEEL--NAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEEL 816
Query: 639 LKNLENGFYINDQKADLLLLENKK-----LKEYILYLK---NNIEKYREGQEALMHTSND 690
L +A+LL + NK+ LK+ I LK N++ + Q ++ +
Sbjct: 817 L------------EAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQE 864
Query: 691 LSRQLIAQEAQYKDLWAEFQTTVKILVDNGEETLQDINNLTDKLRER-DEKMQH 743
L L +E Q + A + K L + G + LQD+ + L+ E QH
Sbjct: 865 LQNLLKGKEEQMNTMKAVLEEKEKDLANTG-KWLQDLQEENESLKAHVQEVAQH 917
Score = 58.2 bits (139), Expect = 3e-08
Identities = 117/612 (19%), Positives = 253/612 (41%), Gaps = 90/612 (14%)
Query: 52 VEQSLQSDYFKCNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPN 111
VE+ L+++ K + K ++D+ +K L+E EI +++L K L T
Sbjct: 813 VEELLEAELLKVANKEKT-VQDLKQEIKALKE---------EIGNVQLEKAQQLSIT--- 859
Query: 112 SIKRELEECVRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELA 171
S +EL+ ++ ++NT+K + E ++ K + DL + NE+L +E+A
Sbjct: 860 SKVQELQNLLKGKEE----QMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVA 915
Query: 172 RKHARFVLSLNQTMEKKATTTVYINE---TYTKINLKREDIALQKKCIQEAEELMEKERA 228
+ + + S +Q E + NE + + D++ + + +Q+ ++ + ++
Sbjct: 916 QHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKS 975
Query: 229 EYLIRKQELTAQINEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNL 288
+ KQ+ Q + F E+ ++ + +++KE+ L ++ +K+ V +D
Sbjct: 976 QIEQLKQQNYQQASSFPPHEELLKVIS-EREKEISGLWNELDSLKDAVEHQRKKNND--- 1031
Query: 289 EIARLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLV- 347
L E + WE + L +L+ K+ + +++ + E E L K+ V
Sbjct: 1032 ----LRE--KNWE-AMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVS 1084
Query: 348 --------ETLHAARMEYKDL------REKMKTLARQYKIVLSEEEKAFLQKQKIHDENQ 393
E LH + K+ E++K L ++K+ ++E LQ E +
Sbjct: 1085 VPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVL--EHKLKEADEMHTLLQL-----ECE 1137
Query: 394 KQLTFISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSANLERESQRCV 453
K + +++ E L + + ++ E ++ ++ KT+ Q Q S+ E E
Sbjct: 1138 KYKSVLAETEGILQKLQRSVEQEENKWKV--KVDESHKTIKQMQSSFTSSEQELE----- 1190
Query: 454 ITQWKMACLRKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIE 513
+++ + I+N R L E + E S +V ++
Sbjct: 1191 ----------------------RLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVR 1228
Query: 514 KLTTELKEEEKAFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYK 573
+L L E +K + + + + EE+ + + Q+N+ + E + +VA +K
Sbjct: 1229 ELKDLLTELQKKL---DDSYSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKVAGDLHK 1285
Query: 574 EKRRKLEELSNIITAQRQEEDLLNNHIFLFTRD-----FSRYISNMEDVKQELQQLRDQE 628
++ S I+ A + N+ + T S ++ Q+L Q +Q+
Sbjct: 1286 AQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQ 1345
Query: 629 SKKNKDHFETLK 640
K K+H++ L+
Sbjct: 1346 LTKEKEHYQVLE 1357
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 90.5 bits (223), Expect = 6e-18
Identities = 133/643 (20%), Positives = 279/643 (43%), Gaps = 51/643 (7%)
Query: 92 LEIESMELNKLYYLLETLPNSIKRELEECVRDARRLNLFEINTIKMRITRTENEIELLKK 151
LE E ME N+ LET N+ ++ A++++L + ++ +I R E ++E +
Sbjct: 723 LEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQ 782
Query: 152 KITDLTKYNEALGEKQEELARKHARFVLSLNQTMEKKATTTVYINETYTKINLKREDI-- 209
+ + K L +Q+ + ++H + SL++ + + K N+K+++
Sbjct: 783 QFKEQEKTMSML--QQDIICKQH--HLESLDRLLTES-------KGEMKKENMKKDEALK 831
Query: 210 ALQKKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVKRMETYQKKKELDKLQTKM 269
ALQ + +E ++ + + A I K+EL +N+ E +E + +K +E+ LQ ++
Sbjct: 832 ALQNQVSEETIKVRQLDSA-LEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKEL 890
Query: 270 SKIKE---TVTVSAAVLSDHNLEIARL---HESIRYWEQEVSELKKDLAILEAKLCFFTD 323
KIK T V+ H L+ + E+IR E E ++ K + +
Sbjct: 891 -KIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQV---------- 939
Query: 324 NKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTL---ARQYKIVLSE--E 378
KL+ ++ K++++ E +A E R+K+ L ARQ KI + + E
Sbjct: 940 --SKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKE 997
Query: 379 EKAFLQKQKIH--DENQKQLTFISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQQ 436
E + ++K+ +H + + + +SQ + L Q + +++ + L++LQ +T+T +
Sbjct: 998 ELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTE 1057
Query: 437 QIK---ILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAITEKIQNAEVRRIE 493
++ +L L+ T ++ LR + A++ E + T K AE+R +
Sbjct: 1058 ALQKREVLETELQNAHGELKSTLRQLQELRDVLQK--AQLSLEEKYTTIKDLTAELRECK 1115
Query: 494 LLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSKYEEIFVKETQINKE 553
+ E ++QE+ +++ ELK+ + + + + + E+ +K ++
Sbjct: 1116 M--EIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEK 1173
Query: 554 KEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISN 613
E EL E Q++ + + + +L E I+ QE L I + +
Sbjct: 1174 SELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEI----ERTQQRMKE 1229
Query: 614 MEDVKQELQQLRDQESKKNKDHFETLKNLENGFYINDQKADLLLLENKKLKEYILYLKNN 673
ME V +E +Q + K+ D + L+ + + + + + I L +
Sbjct: 1230 MESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSE 1289
Query: 674 IEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTTVKIL 716
+E ++ + N L+ +L A + + L A Q +K L
Sbjct: 1290 LEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKL 1332
Score = 78.2 bits (191), Expect = 3e-14
Identities = 160/761 (21%), Positives = 318/761 (41%), Gaps = 114/761 (14%)
Query: 131 EINTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFVLSLNQTMEKKAT 190
E++ + EN++E +K + + ++L E +EE + L QT + K
Sbjct: 299 EVSAQDKVLREAENKLEQSQKMVIEK---EQSLQESKEECIKLKVDL---LEQTKQGKRA 352
Query: 191 TTVYINETYTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREV 250
Y L + +KK E +EK +AE I ++ LT E EN R
Sbjct: 353 ERQRNEALYNAEELSKAFQQYKKK----VAEKLEKVQAEEEILERNLTNC--EKENKRLQ 406
Query: 251 KRMETYQKKKELDKLQTKMSKIKETVT---VSAAVLSDHNLEI-ARLHESIRYWEQEVSE 306
+R Y K EL+ L+ K+ ++KE +++ N E+ A+L ES + + SE
Sbjct: 407 ERCGLY--KSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESE 464
Query: 307 LKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKT 366
L+ IL K +N+E ++ +NE L+ +Q +E+ +R+E + L + +
Sbjct: 465 LENKDEILRDKFSLMNENRELKVRVA--AQNERLDLCQQEIES---SRVELRSLEKIISQ 519
Query: 367 LARQYKIVLSEEEKAFLQKQKIHDENQKQ----------LTFISQKEYFLSQKRVDIKNM 416
L + ++ K++L K ++ + K+ IS+ L+ K +I+ +
Sbjct: 520 LPLKRELF---GFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKL 576
Query: 417 E---------EGLITLQELQQATK------------------TVYQQQIKILSANLERES 449
+ LIT + Q+++K +V Q ++ E+E
Sbjct: 577 HANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKER 636
Query: 450 QRCVITQWKMACLRKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFV 509
QR V ++ + + +K + T + Q + +E + +S + E++
Sbjct: 637 QRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKC 696
Query: 510 AQIEKLTTELKEEEKAFVN---KEKMLMKEL-SKYEEIFVKETQINKEKEEELVEYLPQL 565
+Q+ L +L+E+ A+ + K L +EL K E+I ET IN E E+ + +
Sbjct: 697 SQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAK 756
Query: 566 QVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQQLR 625
++ +++KE +++E L + + Q+ + + +D ++E + + L + +
Sbjct: 757 KIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESK 816
Query: 626 DQESKKNKDHFETLKNLENGFYINDQ--------------KADLLLLEN----------- 660
+ K+N E LK L+N ++++ K +L+L N
Sbjct: 817 GEMKKENMKKDEALKALQN--QVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEK 874
Query: 661 --KKLKEYI------LYLKNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTT 712
KK E + L +KN+ + Q ++ + +Q++ QE + QT
Sbjct: 875 QLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTK 934
Query: 713 VKILVDNGEETLQ-DINNLTDKLRERDEKMQ---HVSTWLRGSLEGL-----RLLVEQES 763
++ V E+ LQ + +KLR+ +EK + H + R + L ++ +E +
Sbjct: 935 LEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQ 994
Query: 764 PMDLLSKQQLRAL-LVTSKEEKTCQLS--DLVIPNYATNIQ 801
+ LSK + + L E K LS D+++ T ++
Sbjct: 995 YKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELE 1035
Score = 70.9 bits (172), Expect = 5e-12
Identities = 154/806 (19%), Positives = 331/806 (41%), Gaps = 103/806 (12%)
Query: 44 EALEQLFVVEQSLQSDYFKCNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIES--MELNK 101
E+ + + +E L++ ++ + ++ + V+ + + + EIES +EL
Sbjct: 453 ESRQSILKLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRS 512
Query: 102 LYYLLETLPNSIKRELEECVRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNE 161
L ++ LP +KREL L+ +++++ + R E K I++L
Sbjct: 513 LEKIISQLP--LKREL---FGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISEL---RI 564
Query: 162 ALGEKQEELARKHARFVLSLNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEA-- 219
L K+ E+ + HA L+ NQ + + T E+ +L+ E + L + E+
Sbjct: 565 KLAIKEAEIQKLHAN--LTANQ-LSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVK 621
Query: 220 -------EELMEKERAEYLIRKQELTAQINEFENTR--------------EVKRMETYQK 258
+ EKER + +EL ++ + E ++ + E +K
Sbjct: 622 DQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEK 681
Query: 259 KKELDKLQTKMSK-------IKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDL 311
KL+++M+K +++ + S + A L + + +++ L+ ++
Sbjct: 682 ASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNI 741
Query: 312 AILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQY 371
K+C + +K I ++ E +I++L L ++K+ + M L Q
Sbjct: 742 NTEHEKICLAFEKAKK---IHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSML--QQ 796
Query: 372 KIVLSEEEKAFLQ------KQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLITLQE 425
I+ + L K ++ EN K+ + + +S++ + ++ ++ L
Sbjct: 797 DIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSAL----- 851
Query: 426 LQQATKTVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKAE-IQAITEK- 483
+ K + L N E+ ++ ++ CL+K+ KIK +Q +E+
Sbjct: 852 --EICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKE-----LKIKNHSLQETSEQN 904
Query: 484 --IQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSKYE 541
+Q+ ++ ++L + + R E+ ++EK ++L++E + ++++ +
Sbjct: 905 VILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKC 964
Query: 542 EIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHIF 601
E E + ++K EL Q+++ +YKE+ K+E+ I+ +R E N +
Sbjct: 965 ESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEK--EIMHLKRDGE---NKAMH 1019
Query: 602 LFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNLENGFYINDQKADLLLL--- 658
L D ++ K EL++ + + K T L QK ++L
Sbjct: 1020 LSQLDMI-----LDQTKTELEKKTNAVKELEKLQHSTETELTEAL----QKREVLETELQ 1070
Query: 659 ----ENKKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTTVK 714
E K + L++ ++K + E T DL+ +L + + +D E +
Sbjct: 1071 NAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQ 1130
Query: 715 ILVDNGEETLQ---DINNLTDKLRERDEKMQHVSTWLRGSLEGLRLLVEQ-----ESPMD 766
L + E Q + +L +RE +M+ L G+LE L +++ ES D
Sbjct: 1131 ALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLND 1190
Query: 767 LL--SKQQLR--ALLVTSKEEKTCQL 788
L +K+QLR ++ E++ QL
Sbjct: 1191 KLQNAKEQLREKEFIMLQNEQEISQL 1216
Score = 54.3 bits (129), Expect = 5e-07
Identities = 67/280 (23%), Positives = 131/280 (46%), Gaps = 28/280 (10%)
Query: 356 EYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKN 415
E K LREK+ L +Q ++++ + + IH E + +S E Q+ +
Sbjct: 230 EIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLE-SAQQQAASVPI 288
Query: 416 MEEGLITLQELQQATKTVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKA 475
+EE +I L+ A V ++ + N +SQ+ VI + + K+ K+K
Sbjct: 289 LEEQIINLEAEVSAQDKVLRE-----AENKLEQSQKMVIEKEQSLQESKEEC---IKLKV 340
Query: 476 EIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLMK 535
++ T++ + AE +R NE + +E+S Q +K E E+ +A +E++L +
Sbjct: 341 DLLEQTKQGKRAERQR----NEALYNAEELSKAFQQYKKKVAEKLEKVQA---EEEILER 393
Query: 536 ELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDL 595
L+ E KE NK +E Y +L++ KEK R+L+E +N + + +
Sbjct: 394 NLTNCE----KE---NKRLQERCGLYKSELEI----LKEKLRQLKEENNNGKEKLRIMAV 442
Query: 596 LNNHIFLFTRDFSRYISNME-DVKQELQQLRDQESKKNKD 634
N+ + + + I +E +++ + + LRD+ S N++
Sbjct: 443 KNSEVMAQLTESRQSILKLESELENKDEILRDKFSLMNEN 482
Score = 52.0 bits (123), Expect = 2e-06
Identities = 68/283 (24%), Positives = 132/283 (46%), Gaps = 39/283 (13%)
Query: 436 QQIKILSANLE--RESQRCVITQWK--MACLRKKHARWTAKIKAEIQAITEKIQNAEVRR 491
Q+IK L L R+ C++TQ M H T +A++ + Q A
Sbjct: 229 QEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQS-RAKVSMLESAQQQAA--S 285
Query: 492 IELLNETSFR-QQEISGFVAQIEKLTTELKEEEKAFVNKEKMLM---KELSKYEEIFVKE 547
+ +L E + E+S + + +L++ +K + KE+ L +E K + +++
Sbjct: 286 VPILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQ 345
Query: 548 TQINKEKEEELVEYL---PQLQVAEQEYKEK-RRKLEELSNIITAQRQEEDLLNNHIFLF 603
T+ K E + E L +L A Q+YK+K KLE++ + EE++L ++
Sbjct: 346 TKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKV-------QAEEEILERNLTNC 398
Query: 604 TRDFSR-------YISNMEDVKQELQQLRDQESK-KNKDHFETLKNLENGFYINDQKADL 655
++ R Y S +E +K++L+QL+++ + K K +KN E + + + +
Sbjct: 399 EKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSI 458
Query: 656 LLLENKKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIAQ 698
L LE++ L+N E R+ + +LM+ + +L ++ AQ
Sbjct: 459 LKLESE--------LENKDEILRD-KFSLMNENRELKVRVAAQ 492
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 90.1 bits (222), Expect = 7e-18
Identities = 165/849 (19%), Positives = 338/849 (39%), Gaps = 166/849 (19%)
Query: 47 EQLFVVEQSLQSDYFK----CNEEAKIFLKDIAVAVKK-LEEMRKATIDLLEIESMELNK 101
E+L V++Q Q++ K C +E + LKD + + +EEM + T++ L+++ EL
Sbjct: 629 EKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELES 688
Query: 102 L-----------------YYLLETLPNSIKRELEECVRDARRLNLFEINTIKMRITRTEN 144
L +L+ + +K+ELE + + + + ++++I I E
Sbjct: 689 LSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSI---IKEHEV 745
Query: 145 EIELLKKKITDLTKYNEALGEKQEELARKHARFVLSLNQTMEK------KATTTVYINET 198
I+ +K + D E L +++++ ++H V +L +++ +A+ + + ++
Sbjct: 746 SIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQS 805
Query: 199 YTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQ--ELTAQINEFENTREVKRMETY 256
Y ++ A +++ Q ++L++ E L+ KQ E+ AQ + + +++
Sbjct: 806 YQSATHEQTK-AYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQ 864
Query: 257 QKKKELDKLQTKMS-KIKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSEL----KKDL 311
++L+K ++M K+K V + L D N E + + + E + ++ KK++
Sbjct: 865 DLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEI 924
Query: 312 AILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQY 371
IL KL D+ L++ E+ K K + + + + K+++E +K
Sbjct: 925 EILTQKLSAKEDSIHILNE-------EYETKFKNQEKKMEKVKQKAKEMQETLK------ 971
Query: 372 KIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLITLQELQQATK 431
+K Q+ K+ E + +SQKE + K +++ I+ + +
Sbjct: 972 -------KKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGIS--DAVSRLE 1022
Query: 432 TVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAITEKIQNAEVRR 491
T ++QI+ L+ + R VI+ W EK N +
Sbjct: 1023 TNQKEQIESLT-EVHRRELNDVISIW------------------------EKKLNQQAEE 1057
Query: 492 IELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSKYEEIFVKETQIN 551
++ ++E +++E + ELK++ F +++ + KE++ +E VK+
Sbjct: 1058 LQEIHEIQLQEKE---------QEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTL 1108
Query: 552 KEKEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHIFLF-------T 604
E +E+L + + Q+ + + LE+L + +E L +
Sbjct: 1109 NELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDK 1168
Query: 605 RDFSRYISNMEDVKQELQQLRDQESKKNK---DHFETLKNLENGFYINDQ---KADLLLL 658
R S S ++ +E Q L+ K NK D K L I K LL
Sbjct: 1169 RKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALL 1228
Query: 659 ENK---------------------------KLKEYILY-------LKNNIEKYREGQEAL 684
E K K+KE +L L+ + + E Q L
Sbjct: 1229 EAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTL 1288
Query: 685 MHTSNDLSRQLIAQEAQYKDLWAEFQTTV---------------------KILVDNGEET 723
+ + QL +E Q K + A+ ++ V + +E
Sbjct: 1289 NISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKEL 1348
Query: 724 LQDINNLTDKLRERDEKMQHVSTWLRGSLEGLRLLVEQESPMDLLSKQQLRALLVTSKEE 783
++IN +T E EK +S+ S + L V+ ++ + L K+ + L +E
Sbjct: 1349 SENINAVTLMKEELKEKKVEISSL---SKQLTDLNVQLQNSISLSEKEAAISSLRKQYDE 1405
Query: 784 KTCQLSDLV 792
+ C+L D V
Sbjct: 1406 EKCELLDQV 1414
Score = 81.3 bits (199), Expect = 3e-15
Identities = 124/569 (21%), Positives = 251/569 (44%), Gaps = 88/569 (15%)
Query: 191 TTVYINETYTKINLKREDIALQ--KKCIQEAEELMEKERAEYLIRKQELTAQINEFENTR 248
T+V ET + +KR++ L+ K+ IQ +E +E +++L ++ E E
Sbjct: 276 TSVKTLETLQQ-RVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELE--- 331
Query: 249 EVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSELK 308
++K + +K K + +L+ + I++ V+++ + +HE++ E+E+++L+
Sbjct: 332 KIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQ---MHETLEMKEEEIAQLR 388
Query: 309 KDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLA 368
+ + + + KEK + + +E + L+ + +T A R ++ E++KT+
Sbjct: 389 SRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQ---KTEEARRKLKAEMDEQIKTIE 445
Query: 369 RQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDI--KNMEEGLITLQEL 426
+ SEEE+ LQ++ + Q+ VD+ K+ EE + LQ+L
Sbjct: 446 K-----TSEEERISLQQELSR----------------VKQEVVDVMKKSSEEQIAKLQKL 484
Query: 427 QQATKTVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAITEKIQN 486
+ +Q++ ERE Q Q K+A L K + + + + Q + ++
Sbjct: 485 HEKELARKEQELTKKLQTREREFQE----QMKVA-LEKSQSEYLKISQEKEQQESLALEE 539
Query: 487 AEVRRIELLNETSFR----QQEISGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSKYEE 542
E+++ +L E+ + QQE + +I +L + L++ + N+ K L L +
Sbjct: 540 LELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKN 599
Query: 543 IFVKETQINKEKEEELVEYL---------PQLQVAEQEYKEKRRKLEELSNIITAQRQEE 593
KE + EK + +E L +LQV +Q+Y+ + KL E ++++E
Sbjct: 600 KHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLRE-----KCEQEKE 654
Query: 594 DLLNNHIFLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNLENGFYINDQKA 653
LL + + F +I M + E ++ E E+L + +
Sbjct: 655 TLLKDKEII----FQAHIEEMNEKTLEKLDVKQTE-------LESLSS----------EL 693
Query: 654 DLLLLENKKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTTV 713
+L KL+E + LK+ +K ++ EA M + +Q + ++ K+ Q T
Sbjct: 694 SEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQV--DSIIKEHEVSIQRTE 751
Query: 714 KILVDNGEETLQDINNLTDKLRERDEKMQ 742
K L D IN L L+ERD+ ++
Sbjct: 752 KALKD-------QINQLELLLKERDKHLK 773
Score = 80.9 bits (198), Expect = 5e-15
Identities = 152/771 (19%), Positives = 320/771 (41%), Gaps = 121/771 (15%)
Query: 68 KIFLKDIAVAVKK----LEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEECVRD 123
KI ++D+ ++K +E+ K+ + E + + NK + I E E +
Sbjct: 860 KIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKE----QEQTKQILVEKENMILQ 915
Query: 124 ARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFVLSLNQ 183
R EI + +++ E+ I +L ++ K E EK ++ A++ + +
Sbjct: 916 MREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKE-------MQE 968
Query: 184 TMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQINE 243
T++KK L ++ L+K+ A EL +KE+ ++ + E+ AQ N
Sbjct: 969 TLKKK---------------LLDQEAKLKKELENTALELSQKEK-QFNAKMLEM-AQANS 1011
Query: 244 FENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHE-SIRYWEQ 302
+ V R+ET QK++ + ++ + +++ L+ E+ +HE ++ EQ
Sbjct: 1012 AGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQ 1071
Query: 303 EVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDLRE 362
EV+ELK+ + + EK E +I L E +L+E
Sbjct: 1072 EVAELKQKILLFGC------------------EKEEMNKEITWLKEEGVKQDTTLNELQE 1113
Query: 363 KMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNM-EEGLI 421
++K + + +E K +K+ + K L ++ FL ++ V++K + EE
Sbjct: 1114 QLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSL----KENTFLQEQLVELKMLAEEDKR 1169
Query: 422 TLQELQQATKTVYQQQIKILSAN------LERESQRCVITQWKMA-----CLRKKHARWT 470
+ EL KT ++ + S++ LE +S ++A C +K A
Sbjct: 1170 KVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLE 1229
Query: 471 AKIK-------AEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEE 523
AK ++ AI +I + + R ++ + +S AQ+ +LT E
Sbjct: 1230 AKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLN 1289
Query: 524 KAFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEELS 583
+F L + KE QI K + ++ + + + ++E +++ E
Sbjct: 1290 ISFQQATHQLEE----------KENQI-KSMKADIESLVTEKEALQKEGGNQQQAASEKE 1338
Query: 584 NIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNLE 643
+ IT ++E S I+ + +K+EL++ + + S +K + L+
Sbjct: 1339 SCITQLKKE--------------LSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQ 1384
Query: 644 NGFYINDQKADLLLL------ENKKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIA 697
N +++++A + L E +L + + L ++ + + + + +D S +
Sbjct: 1385 NSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSE 1444
Query: 698 QEAQYKDLWAEFQTTVKILVDNGE-------ETLQDINNLTDKLRERDEKMQHVSTWLRG 750
+ + + + + Q TVK L E E + IN L ++L +++++ L+G
Sbjct: 1445 WKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFD----CLKG 1500
Query: 751 SLEGLRLLVE-QESPMDLLSKQQLRALLVTSKE--EKTCQLSDL--VIPNY 796
+E + +E +ES ++ K Q ++ +KT ++ L V+ NY
Sbjct: 1501 EMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNY 1551
Score = 70.5 bits (171), Expect = 6e-12
Identities = 125/601 (20%), Positives = 262/601 (43%), Gaps = 72/601 (11%)
Query: 44 EALEQLFVVEQSLQSDYFKCNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIESM-ELNKL 102
EA E++ +E + S + E K L+ + ++VK EE KA D LE ES +L +L
Sbjct: 1582 EAEEKILTLENQVYSMKAEL-ETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAEL 1640
Query: 103 YYLLETLPNSIKREL-------EECVRDARRLNLFEINTIKMRITRTENEIELLKKKITD 155
E +IK++L EE + +L E+NT ++ E E+ +L++K+
Sbjct: 1641 KRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNT---KLQEREREVHILEEKLKS 1697
Query: 156 LTKYNEALGEKQEELARKHARFVLSLNQTMEKKATTTVYINETYTKINLKREDIALQKKC 215
+ + + + + A+ V + T +++A + + +TY E I++ ++
Sbjct: 1698 VES-----SQSETLIVPRSAKNVAAY--TEQEEADSQGCVQKTY------EEKISVLQRN 1744
Query: 216 IQEAEELMEK---ERAEYLIRKQELTAQINEFENTREVKRMETYQKKKELDKLQTKMSKI 272
+ E E+L+++ E+ E + E+ Q E E + ++ + + LQ ++ +
Sbjct: 1745 LTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEK 1804
Query: 273 KETVTVSAAVLSD-----HNLEIARLHESIRYWEQEVSELKK-DLAILEAKLCFFTDNKE 326
+ ++ A + +N++ + E++ Q+ + K+ ILE K+
Sbjct: 1805 NKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLV 1864
Query: 327 KLDDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQ 386
+ ++ E E +K ++L ++ D R K L + E+ K+ L +
Sbjct: 1865 RQKEVHRVEMEELTSKYEKL------QALQQMDGRNKPTELLEENT---EEKSKSHLVQP 1915
Query: 387 KIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSANLE 446
K+ + Q + E+ L+ + + + + ++ LQ+ + + +QQ+++IL +
Sbjct: 1916 KLLSNMEAQHNDL---EFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYD 1972
Query: 447 RESQRCVITQWKMACLRKKHARWTAKIKAEIQA-ITEKIQNAEVRRIELLNETSFRQQEI 505
+E + + + + L KH ++ E + +K Q E+ E +N+ + E+
Sbjct: 1973 QEREEKI--KQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAEL 2030
Query: 506 SGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQL 565
+E E + K K+ L + +YEEI +EEE+ + L
Sbjct: 2031 ------LESHQEETNQLLKKIAEKDDDLKRTAKRYEEIL-------DAREEEMTAKVRDL 2077
Query: 566 QVAEQEYKEK-RRKLEELSN-------IITAQRQ--EEDLLNNHIFLFTRDFSRYISNME 615
Q +E ++K ++KLE+ N I+ Q Q ++ L + L ++F I N+E
Sbjct: 2078 QTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLE 2137
Query: 616 D 616
D
Sbjct: 2138 D 2138
Score = 66.6 bits (161), Expect = 9e-11
Identities = 125/581 (21%), Positives = 244/581 (41%), Gaps = 70/581 (12%)
Query: 219 AEELMEKERAEYL-IRKQELTAQINEFENTREVKRMETYQKKKELDKLQTKMSKIKETVT 277
A +++++E+ + I Q + RE +M+ KK ++ + + + ++
Sbjct: 163 AYQMLQREKKKLQGILSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYIS 222
Query: 278 VSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKN 337
V +++ L + +R V LK L LE + FT KE+ + +
Sbjct: 223 VLQT-------QVSLLKQRLRNGPMNVDVLKP-LPQLEPQAEVFT--KEENPESDGEPVV 272
Query: 338 EFLNKIKQLVETLHAARMEYKDLREKMKTLARQYK--IVLSEEEKAFLQKQKIHDENQKQ 395
E +K L ETL ++L ++ K + +K L EK LQ+Q DE ++
Sbjct: 273 EDGTSVKTL-ETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQL--DERLQE 329
Query: 396 LTFISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSANLERESQRCVIT 455
L I K+ +++K I + + +++L+Q V + + + LE + +
Sbjct: 330 LEKI--KDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEE----- 382
Query: 456 QWKMACLRKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKL 515
++A LR + + T + + E++ EK + A +E T+ + +E KL
Sbjct: 383 --EIAQLRSRIKQMTTQGE-ELREQKEKSERAAFEELEKALSTAQKTEEAR------RKL 433
Query: 516 TTELKEE----EKAFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQE 571
E+ E+ EK + L +ELS+ ++ V + K+ EE + L +L
Sbjct: 434 KAEMDEQIKTIEKTSEEERISLQQELSRVKQEVV---DVMKKSSEEQIAKLQKLHE---- 486
Query: 572 YKEKRRKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYIS-NMEDVKQELQQLRDQESK 630
KE RK +EL+ + Q +E + + S Y+ + E +QE L + E +
Sbjct: 487 -KELARKEQELTKKL--QTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQ 543
Query: 631 KNKDHFETLKNLENGFYINDQKADLLLLENKKLKEYILYLKNNIEKYREGQEALMHTSND 690
K E+ L + L E + + IL L++++EK + + + S D
Sbjct: 544 KKAILTESENKLRD-----------LQQEAETYRTRILELESSLEKSLQENK---NQSKD 589
Query: 691 LSRQLIAQEAQYKDLWAEFQTTVKILVDNGEETLQDINNLTDKLRERDEKMQHVSTWLRG 750
L+ L A++ ++ + ++V+ + L+ + + D L EK+Q + +
Sbjct: 590 LAVHLEAEKNKHNK-------EITVMVEKHKTELESLKHQQDALWT--EKLQVLKQQYQT 640
Query: 751 SLEGLRLLVEQESPMDLLSKQQLRALLVTSKEEKTCQLSDL 791
+E LR EQE L K+ + + EKT + D+
Sbjct: 641 EMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDV 681
Score = 56.2 bits (134), Expect = 1e-07
Identities = 90/436 (20%), Positives = 192/436 (44%), Gaps = 55/436 (12%)
Query: 113 IKRELEECVRDARRLNLFEINTIKMRIT-RTENEIELLKKKITDLTKYNEA--LGEKQEE 169
++R L E + +R+ + T+ R + + L+K + + ++ + +G QEE
Sbjct: 1741 LQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEE 1800
Query: 170 LARKHARFVLSLNQTMEKKATTTVYINETYTKINLKR--EDI--ALQKK---C------I 216
L K+ ++ L + Q +EK+ N K NL+ +D+ LQ+K C I
Sbjct: 1801 LEEKNKKYSLIVAQHVEKEGGK----NNIQAKQNLENVFDDVQKTLQEKELTCQILEQKI 1856
Query: 217 QEAEELMEKERAEYLIRKQELTAQINEFENTREVKRMETYQKKKELDKLQTKMSKIKETV 276
+E + + +++ + + +ELT +++E + +++M+ K EL L+ + ++
Sbjct: 1857 KELDSCLVRQKEVHRVEMEELT---SKYEKLQALQQMDGRNKPTEL--LEENTEEKSKSH 1911
Query: 277 TVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFF-TDNKEKLDDISNDE 335
V +LS+ + L + E+E +L K++ L+ L +++++L+ + +
Sbjct: 1912 LVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEY 1971
Query: 336 KNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLS--EEEKAFLQKQKIHDENQ 393
E KIKQ E L +K L R++ L+ E+E K+ I+ +
Sbjct: 1972 DQEREEKIKQEQEDLELKH------NSTLKQLMREFNTQLAQKEQELEMTIKETINKAQE 2025
Query: 394 KQLTFISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSANLERESQRCV 453
+ + + +Q I ++ L K ++ +IL A E + +
Sbjct: 2026 VEAELLESHQEETNQLLKKIAEKDDDL----------KRTAKRYEEILDAREEEMTAKVR 2075
Query: 454 ITQWKMACLRKKHARWTAKIKAEIQAITE-----KIQNAEVRRIELLNETSFRQQEISGF 508
Q ++ L+KK+ + K++ E + ++Q ++ L++++ ++QE F
Sbjct: 2076 DLQTQLEELQKKYQQ---KLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQE---F 2129
Query: 509 VAQIEKLTTELKEEEK 524
QI L LK+ EK
Sbjct: 2130 REQIHNLEDRLKKYEK 2145
Score = 46.2 bits (108), Expect = 1e-04
Identities = 87/460 (18%), Positives = 192/460 (41%), Gaps = 68/460 (14%)
Query: 51 VVEQSLQSDYFKCNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLLETLP 110
+V Q ++ + K N +AK L+++ V+K + ++ T +LE +
Sbjct: 1811 IVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKI-------------- 1856
Query: 111 NSIKRELEECVRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEEL 170
+EL+ C+ + E++ ++M ++ E +++ K E L E EE
Sbjct: 1857 ----KELDSCL-----VRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEK 1907
Query: 171 ARKHARFVLSLNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKERAEY 230
++ H ++ K + N++ + L+ K + AE +K E
Sbjct: 1908 SKSH---------LVQPKLLS-----------NMEAQHNDLEFK-LAGAEREKQKLGKEI 1946
Query: 231 LIRKQELTAQINEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEI 290
+ +++L E + E+ + E Q+++E K + + ++K T+ ++ + N ++
Sbjct: 1947 VRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLK-QLMREFNTQL 2005
Query: 291 ARLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISND--EKNEFLNKIKQLVE 348
A+ + + E + E +EA+L ++E+ + + EK++ L + + E
Sbjct: 2006 AQKEQEL---EMTIKETINKAQEVEAEL--LESHQEETNQLLKKIAEKDDDLKRTAKRYE 2060
Query: 349 TLHAARME-----YKDLREKMKTLARQYKIVLSEEEKA---FLQKQKIHDENQKQLTFIS 400
+ AR E +DL+ +++ L ++Y+ L +EE + ++ + ++ T IS
Sbjct: 2061 EILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLIS 2120
Query: 401 QKEYFLSQKRVDIKNMEEGLITLQELQQATK--------TVYQQQIKILSANLERESQRC 452
+ + R I N+E+ L ++ AT +Y + + E E R
Sbjct: 2121 DSKLKEQEFREQIHNLEDRLKKYEKNVYATTVGTPYKGGNLYHTDVSLFGEPTEFEYLRK 2180
Query: 453 VITQWKMACLRKKHARWTAKIKAEIQAITEKIQNAEVRRI 492
V+ ++ M K A+ + T+KI E R+
Sbjct: 2181 VLFEYMMGRETKTMAKVITTVLKFPDDQTQKILEREDARL 2220
>gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]
Length = 1088
Score = 89.7 bits (221), Expect = 1e-17
Identities = 157/752 (20%), Positives = 301/752 (40%), Gaps = 130/752 (17%)
Query: 52 VEQSLQSDYFKCNEEAKIFLKDIAVAVKKLEEMR---KATIDLLEIESMELNKLYYLLET 108
V + + ++ + + E + K++ + K LEEM + L + KL +L++
Sbjct: 259 VAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQS 318
Query: 109 LPNSIKRELEECVRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEALGEKQE 168
S K E+ R R + E + L+ + K N L E+
Sbjct: 319 KGLSAKATEEDHERTRR-------------LAEAEMHVHHLESLLEQKEKENSMLREEM- 364
Query: 169 ELARKHARFVLSLNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKERA 228
H RF + + + KA TV I +K I+ ++ +++ EE ++ ++
Sbjct: 365 -----HRRFE-NAPDSAKTKALQTV--------IEMKDSKISSMERGLRDLEEEIQMLKS 410
Query: 229 EYLIRKQELTAQINEFENTREVKRM---ETYQKKKELDKLQTKMSKIKETVTVSAAVLSD 285
+ +E ++ + E R + + Q K+EL + T++ ++ + SD
Sbjct: 411 NGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSD 470
Query: 286 HNLEIARLHESIRYWEQEVSELKKDLAI----LEAKLCFFTDNKEKLDDISND------- 334
I L ES+ EQ + L+ ++ LE K +++ D++ +
Sbjct: 471 SKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGE 530
Query: 335 -------------EKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQ----------Y 371
+ N KI+ L E L + L+E++K+L
Sbjct: 531 IHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTL 590
Query: 372 KIVLSEEEKAF--LQKQKIHDENQKQLTFISQKEYF------LSQKRVDIKNMEEGLITL 423
+ L+E+E+ L++Q+ DE +KQ + K+ +S + D+ E L+ L
Sbjct: 591 EEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDL 650
Query: 424 QELQQATKT---VYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAI 480
+E + + ++K L LE++ + C+ KM KK + +A + +
Sbjct: 651 KEHASSLASSGLKKDSRLKTLEIALEQKKEECL----KMESQLKKAHEAALEARASPE-M 705
Query: 481 TEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSKY 540
+++IQ+ E +E+S Q E+ + ++++ E +++K E+ + + K
Sbjct: 706 SDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKV 765
Query: 541 EEIFVKETQINKEKEEELVEYL----PQLQVAEQEYKEKRRK----LEELSNI------I 586
+ KE Q+ K+K +++E L + Q+ ++ RK +EEL I
Sbjct: 766 ANLKHKE-QVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQI 824
Query: 587 TAQR-----QEEDLLNNHIFLFTRDFSRYISNMEDVKQEL-----------QQLRDQESK 630
TA+R QEE N + + ME VKQEL Q L ++E+
Sbjct: 825 TAEREMVLAQEESARTN----AEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETH 880
Query: 631 KNKDHFETLKNLENGFYINDQKADLLLLENKKLKEYILYLKNNIEKYREGQEALMHTSND 690
E K+LE + Q+A L + K +L L ++ +K +E AL +
Sbjct: 881 LTNLRAERRKHLEEVLEMK-QEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDR 939
Query: 691 LSRQLIAQEAQYKDLWAEFQTTVKILVDNGEE 722
L +QL Q Q +K++ DN E+
Sbjct: 940 LVQQLKQQT----------QNRMKLMADNYED 961
Score = 75.1 bits (183), Expect = 2e-13
Identities = 134/705 (19%), Positives = 293/705 (41%), Gaps = 105/705 (14%)
Query: 143 ENEIELLKKKITDLTKYNEALGEKQEELARKHARFVLSLNQTMEKKATTTVYINETYTKI 202
+ E L K + + +T + E QEE +H + + Q ++ + +N+ + +
Sbjct: 195 KKERALRKDEASKITIWKEQYRVVQEE--NQHMQMTI---QALQDELRIQRDLNQLFQQD 249
Query: 203 NLKREDIALQKKCIQE-AEELMEKERAEYLIRKQELTAQINEFENTREVKRMETYQKKKE 261
+ R + C+ E EE ++ AE+ + +EL T E + +K+
Sbjct: 250 SSSRTG----EPCVAELTEENFQRLHAEHERQAKELFL----LRKTLEEMELRIETQKQT 301
Query: 262 LDKLQTKMSKIKETVT---VSAAVLSDHNLEIARLHES---IRYWEQEVSELKKDLAILE 315
L+ + K+ E + +SA + + RL E+ + + E + + +K+ ++L
Sbjct: 302 LNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLR 361
Query: 316 AKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVET-LHAARMEYKDLREKMKTLARQYKIV 374
++ + ++ + K + L + ++ ++ + + +DL E+++ L +
Sbjct: 362 EEM------HRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALS 415
Query: 375 LSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVY 434
E E+ Q + ++ I Q + LS+K ++ ++ L TL +K
Sbjct: 416 TEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSK--- 472
Query: 435 QQQIKILSANLERESQRCVITQWKMACLR----KKHARWTAKIKAEIQAITEKIQNAEVR 490
Q I++L +L + QR I Q ++ LR +K K K +IQ + E+
Sbjct: 473 -QHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTK-QIQDMAEEKGTQAGE 530
Query: 491 RIELLNETSFRQQEISGFVAQIEKLTTELKEEEK---AFVNKEKMLMKELSKYEEIFVKE 547
+L + ++++++ +IE L +L+++EK + + K L + + +
Sbjct: 531 IHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTL 590
Query: 548 TQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDL--LNNHIFLFTR 605
+ EKE + ++ EQ +++R K EE+ N ++DL L + L
Sbjct: 591 EEALAEKERTIE------RLKEQRDRDEREKQEEIDNY------KKDLKDLKEKVSLLQG 638
Query: 606 DFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNLENGFYINDQKADLLLLENK---- 661
D S +++ D+K+ L KK+ LK LE + +K + L +E++
Sbjct: 639 DLSEKEASLLDLKEHASSLASSGLKKDS----RLKTLE--IALEQKKEECLKMESQLKKA 692
Query: 662 -----------KLKEYILYLKNNIEKYREGQ--------------EALMHTSNDLSRQLI 696
++ + I +L+ I +Y++ + + + ND +++
Sbjct: 693 HEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIA 752
Query: 697 AQEAQYKD-------LWAEFQTTVKILVDNGEETLQDINNLTDKL-------RERDEKMQ 742
E Q KD L + Q K EE + +NL D R++D++++
Sbjct: 753 ELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIE 812
Query: 743 HVSTWLRGSLE---GLRLLVEQESPMDLLSKQQLRALLVTSKEEK 784
+ LR S++ +++ QE +++Q+ LL+ ++ K
Sbjct: 813 ELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVK 857
Score = 51.6 bits (122), Expect = 3e-06
Identities = 114/523 (21%), Positives = 208/523 (39%), Gaps = 71/523 (13%)
Query: 278 VSAAVLSDHNLEIAR------LHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDI 331
VS A H+L AR L ++ +E L+KD+ + E+KL
Sbjct: 133 VSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKL------------- 179
Query: 332 SNDEKNEFLNKIKQLVET-LHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHD 390
+ +N IK L R KD K+ QY++V E + + Q + D
Sbjct: 180 -----SSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQD 234
Query: 391 E--NQKQLTFISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIK---ILSANL 445
E Q+ L + Q++ S R + E +E Q +++Q K +L L
Sbjct: 235 ELRIQRDLNQLFQQD---SSSRTGEPCVAE---LTEENFQRLHAEHERQAKELFLLRKTL 288
Query: 446 ERESQRCVITQWKMACLRKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEI 505
E E + + TQ + R + + ++ + + ++ K + R L E +
Sbjct: 289 E-EMELRIETQKQTLNARDESIKKLLEM-LQSKGLSAKATEEDHERTRRLAEAEMHVHHL 346
Query: 506 SGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSKYEEIFVKETQIN------KEKEEELV 559
+ Q EK + L+EE K + I +K+++I+ ++ EEE+
Sbjct: 347 ESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQ 406
Query: 560 EYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQ 619
++ +E +E+ +++E R + N I ++ SR + + ++
Sbjct: 407 MLKSNGALSTEEREEEMKQME-------VYRSHSKFMKNKIGQVKQELSRKDTELLALQT 459
Query: 620 ELQQLRDQESKKNKDHFETLKNLENGFYINDQKADLLLLENKKL------KEYILYLK-N 672
+L+ L +Q S +K H E LK +Q+A +L E L KE +L K
Sbjct: 460 KLETLTNQFS-DSKQHIEVLK---ESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTK 515
Query: 673 NIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTTVKILVDNGEETLQDINNLTD 732
I+ E + +DL L +E + L + ++N +E L+D
Sbjct: 516 QIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKK--------IENLQEQLRDKEKQMS 567
Query: 733 KLRERDEKMQHVSTWLRGSLEGL-RLLVEQESPMDLLSKQQLR 774
L+ER + +Q +T +L L L E+E ++ L +Q+ R
Sbjct: 568 SLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDR 610
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 89.7 bits (221), Expect = 1e-17
Identities = 137/751 (18%), Positives = 305/751 (40%), Gaps = 99/751 (13%)
Query: 79 KKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEECVRDARRLNLFEINTIKMR 138
K L+E + T+D L++E ++N L + L +LE + ++L ++ K +
Sbjct: 1001 KSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTD-DLEGSLEQEKKLRA-DLERAKRK 1058
Query: 139 ITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFVLS-LNQTMEKKATTTVYINE 197
+ E ++++ ++ I DL + + EK K F LS L ++ + ++ +
Sbjct: 1059 L---EGDLKMSQESIMDLENDKQQIEEKL-----KKKEFELSQLQAKIDDEQVHSLQFQK 1110
Query: 198 TYTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVKRMETYQ 257
++ + E++ + + +EK+R++ +E++ ++ E + +
Sbjct: 1111 KIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKK 1170
Query: 258 KKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAK 317
++ E K++ +LE A L E + L+K A A+
Sbjct: 1171 REAEFQKMR-------------------RDLEEATLQH-----EATAATLRKKQADSVAE 1206
Query: 318 LCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLSE 377
L DN +++ EK+E +I + + A ++ +T+ Q+ + ++
Sbjct: 1207 LGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAK 1266
Query: 378 EEKAFLQKQKIHDENQKQLTF----------ISQKEYFLSQ----KRVDIKNMEEGLITL 423
+E+ Q Q IHD N ++ + +KE +SQ K+ + +EE +
Sbjct: 1267 DEQ---QTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQM 1323
Query: 424 QELQQATKTV------YQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEI 477
+E +A + + +L E E + Q ++ + A+W K + +
Sbjct: 1324 EEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDA 1383
Query: 478 QAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLMKEL 537
TE+++ A+ + + L E + + A +EK L+ E + LM++L
Sbjct: 1384 IQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVED-------LMRDL 1436
Query: 538 SKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLN 597
+ + + ++ L E+ ++KL+E + A ++E L+
Sbjct: 1437 ERSHTACATLDKKQRNFDKVLAEW--------------KQKLDESQAELEAAQKESRSLS 1482
Query: 598 NHIFLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNLENG----FYINDQKA 653
+F + + +E +++E + L+++ S + ET KNL+ + +K+
Sbjct: 1483 TELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKS 1542
Query: 654 DLLLLENKKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTTV 713
DL + L+E L++ K Q L ++L R++I ++ + + L Q
Sbjct: 1543 DLQV----ALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQ--- 1595
Query: 714 KILVDNGEETLQDINNLTDKLRERDEKMQHVSTWLRGSLEGLRLLVEQESPMDLLSKQQL 773
E LQ + L ++R R++ ++ + + G L + + + + +++ L
Sbjct: 1596 -----RAAEALQSV--LDAEIRSRNDALR-LKKKMEGDLNEMEIQLGHSNRQMAETQKHL 1647
Query: 774 RALLVTSKEEKTCQLSDLVIPNYATNIQLNI 804
R + K+ + L D + N QL I
Sbjct: 1648 RTVQGQLKDSQ-LHLDDALRSNEDLKEQLAI 1677
Score = 64.3 bits (155), Expect = 4e-10
Identities = 129/724 (17%), Positives = 290/724 (40%), Gaps = 75/724 (10%)
Query: 71 LKDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEEC-VRDARRLNL 129
L+ + ++K + K ID + L+K +E +++ + E +D ++ L
Sbjct: 1214 LQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQL 1273
Query: 130 F-EINTIKMRITRTENE----IELLKKKITDLTKYNEALGEKQEELARKHARFVLSLNQT 184
++N K R+ E +E + I+ LTK +AL ++ EEL R+ + +
Sbjct: 1274 IHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQ-------MEEE 1326
Query: 185 MEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKERAEYLI-RKQELTAQINE 243
+ K + + +L RE +++ E + + K +E R + T I
Sbjct: 1327 TKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQR 1386
Query: 244 FENTREVKRMETYQKKKELDKLQTKMSK---IKETVTVSAAVLSDHNLEIARLHESIRYW 300
E E K+ + ++ + +T SK +++T + D ++ R H +
Sbjct: 1387 TEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATL 1446
Query: 301 EQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKN------EFLNKIKQLVETLHAAR 354
+++ K LA + KL +++ +L+ + ++ + N +++V+ L R
Sbjct: 1447 DKKQRNFDKVLAEWKQKL---DESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLR 1503
Query: 355 MEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIK 414
E K+L+E++ L Q ++A K+ + E + + E L + I
Sbjct: 1504 RENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKIL 1563
Query: 415 NMEEGLITLQELQQATKTVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIK 474
++ L ++ ++I+ L N +R ++ R R K++
Sbjct: 1564 RVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKME 1623
Query: 475 AEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIE---KLTTELKEEEKAFVNKEK 531
++ + ++ ++ + E Q ++ ++ + +LKE+ +
Sbjct: 1624 GDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNG 1683
Query: 532 MLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYK---EKRRKLE-------- 580
+L++EL + + + + + E+EL++ ++Q+ + ++KLE
Sbjct: 1684 LLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQA 1743
Query: 581 ELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQQLRD-----QESKKNKDH 635
E+ N I R E+ + I++ + +EL++ +D + KKN +
Sbjct: 1744 EVENSIQESRNAEE-----------KAKKAITDAAMMAEELKKEQDTSAHLERMKKNLE- 1791
Query: 636 FETLKNLENGFYINDQKADLLLLENK----KLKEYILYLKNNIE-KYREGQEAL--MHTS 688
+T+K+L++ D+ L L K KL+ + L+N ++ + + G EAL H
Sbjct: 1792 -QTVKDLQHRL---DEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKY 1847
Query: 689 NDLSRQLIAQEAQ-------YKDLWAEFQTTVKILVDNGEETLQDINNLTDKLRERDEKM 741
+++ Q + +DL + Q VK EE + N + R ++
Sbjct: 1848 ERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQHEL 1907
Query: 742 QHVS 745
+ +
Sbjct: 1908 EEAA 1911
Score = 60.1 bits (144), Expect = 8e-09
Identities = 127/567 (22%), Positives = 238/567 (41%), Gaps = 85/567 (14%)
Query: 206 REDIALQKKCIQEAEELMEKERAEYLIRKQELTAQI-NEFENTREVK-RMETYQKKKELD 263
+E++A + +E EE M L K +L Q+ +E EN + + R E K K L
Sbjct: 864 KEELARSEARRKELEEKM----VSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSKIL- 918
Query: 264 KLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFFTD 323
L+ K+ ++ E + + S+ L R E + S LK+D+ LE L
Sbjct: 919 -LEAKVKELTERLEEEEEMNSE-------LVAKKRNLEDKCSSLKRDIDDLELTLT---- 966
Query: 324 NKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLS----EEE 379
EK EK+ NK+K L E + A L ++ K+L ++ L EE+
Sbjct: 967 KVEK-------EKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEED 1019
Query: 380 K--------AFLQKQ--KIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLITLQ-ELQQ 428
K A L++Q + +++ + E + D+K +E ++ L+ + QQ
Sbjct: 1020 KVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQ 1079
Query: 429 ATKTVYQQQIKI--LSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAITEKIQN 486
+ + +++ ++ L A ++ E + Q K+ L+ + +I+AE + KI+
Sbjct: 1080 IEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAE-HTLRAKIEK 1138
Query: 487 AEVRRIELLNETSFRQQEISGFV-AQIEKLTTELKEEEKAFVNKEKMLMKELSKYEEIFV 545
L E S R +E SG AQIE K+ E F + L + ++E
Sbjct: 1139 QRSDLARELEEISERLEEASGATSAQIEM----NKKREAEFQKMRRDLEEATLQHEATAA 1194
Query: 546 KETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHIFLFTR 605
+ + EL E + LQ +Q+ ++++ +L + + +D+ +N
Sbjct: 1195 TLRKKQADSVAELGEQIDNLQRVKQKLEKEKSEL---------KMEIDDMASN-----IE 1240
Query: 606 DFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNLENGFYINDQKADLLLLENKKLKE 665
S+ SN+E + ++ + K++ + + +L N QKA L +N +L
Sbjct: 1241 ALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDL------NMQKA-RLQTQNGELSH 1293
Query: 666 YILYLKNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTTVKILVDNGEETLQ 725
+ ++ I + + ++AL +L RQ+ +E + K+ A LQ
Sbjct: 1294 RVEEKESLISQLTKSKQALTQQLEELKRQM-EEETKAKNAMA--------------HALQ 1338
Query: 726 DINNLTDKLRERDEKMQHVSTWLRGSL 752
+ D LRE+ E+ Q L+ +L
Sbjct: 1339 SSRHDCDLLREQYEEEQEAKAELQRAL 1365
Score = 35.8 bits (81), Expect = 0.17
Identities = 48/216 (22%), Positives = 89/216 (41%), Gaps = 29/216 (13%)
Query: 52 VEQSLQSDYFKCNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPN 111
VE S+Q E+AK + D A+ EE++K +E M+ N LE
Sbjct: 1745 VENSIQESR-NAEEKAKKAITDAAMMA---EELKKEQDTSAHLERMKKN-----LEQTVK 1795
Query: 112 SIKRELEECVRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELA 171
++ L+E + A + +I ++ R+ ENE+++ +K+ G + + A
Sbjct: 1796 DLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKR-----------GAEALKGA 1844
Query: 172 RKHARFVLSLNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEE-----LMEKE 226
K+ R V + E+ + + + K+ K + K+ +EAEE L
Sbjct: 1845 HKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAK---VKSYKRQAEEAEEQANTQLSRCR 1901
Query: 227 RAEYLIRKQELTAQINEFE-NTREVKRMETYQKKKE 261
R ++ + + A I E + N K + +K E
Sbjct: 1902 RVQHELEEAAERADIAESQVNKLRAKSRDVGSQKME 1937
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 89.0 bits (219), Expect = 2e-17
Identities = 138/728 (18%), Positives = 288/728 (39%), Gaps = 94/728 (12%)
Query: 79 KKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEECVRDARRLNLFEINTIKMR 138
K L+E + +D L+ E ++N L L ++ +LE + ++L + ++
Sbjct: 998 KALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVE-DLESSLEQEKKLRV----DLERN 1052
Query: 139 ITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFVLSLNQTMEKKATTTVYINET 198
+ E +++L ++ I DL + L E+ L +K + L +E + T + +
Sbjct: 1053 KRKLEGDLKLAQESILDLENDKQQLDER---LKKKDFEYC-QLQSKVEDEQTLGLQFQKK 1108
Query: 199 YTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVKRMETYQK 258
++ + E++ + + + EK+R++Y +EL+ ++ E + K
Sbjct: 1109 IKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQI--ELNK 1166
Query: 259 KKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKL 318
K+E + L+ + L E+ E V+ L+K A A+L
Sbjct: 1167 KREAEFLKLRRD----------------------LEEATLQHEAMVAALRKKHADSVAEL 1204
Query: 319 CFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLSEE 378
DN +++ EK+EF +I L ++ + +L + +TL Q +
Sbjct: 1205 GEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKN 1264
Query: 379 E-------KAFLQKQKIHDENQKQLTFISQKEYFLSQ----KRVDIKNMEEGLITLQELQ 427
E + QK ++ E + + +KE +SQ K+ + EE L+E
Sbjct: 1265 EEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEEN 1324
Query: 428 QATKTV------YQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAIT 481
+A + + +L E E + Q ++ + A+W K + + T
Sbjct: 1325 KAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRT 1384
Query: 482 EKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSKYE 541
E+++ A+ + + L ++ + + ++ A +EK L+ E
Sbjct: 1385 EELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGE------------------- 1425
Query: 542 EIFVKETQINKEKEEELVEYLPQLQ-VAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHI 600
V++ ++ E+ L L + Q ++ E + K EE + A +E L+ +
Sbjct: 1426 ---VEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTEL 1482
Query: 601 FLFTRDFSRYISNMEDVK-------QELQQLRDQESKKNKDHFETLKNLENGFYINDQKA 653
F + + +E VK QE+ L +Q ++ K E K+ + I +KA
Sbjct: 1483 FKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQ---IELEKA 1539
Query: 654 DLLLLENKKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTTV 713
D+ L L+E L++ K Q L +++ R++ ++ + + L +Q TV
Sbjct: 1540 DIQL----ALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTV 1595
Query: 714 KIL-------VDNGEETLQDINNLTDKLRERDEKMQHVSTWLRGSLEGLRLLVEQESPMD 766
+ + V + E ++ + L E + ++ H + +L+ LR + Q
Sbjct: 1596 ETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQ 1655
Query: 767 LLSKQQLR 774
L LR
Sbjct: 1656 LHLDDALR 1663
Score = 62.0 bits (149), Expect = 2e-09
Identities = 136/709 (19%), Positives = 284/709 (40%), Gaps = 100/709 (14%)
Query: 97 MELNKLYYLLETLPNS------IKRELEECVRDARRLN------LFEINTIKMRITRTEN 144
+E++ L +E++ S I R LE+ + +AR N L E+ T K R+
Sbjct: 1227 LEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAG 1286
Query: 145 EI--ELLKKK--ITDLTKYNEALGEKQEELARKHARFVLSLNQTMEKKATTTVYINETYT 200
E+ +L +K+ ++ L++ +A ++ EEL R+ L + + K + +
Sbjct: 1287 ELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQ-------LEEENKAKNALAHALQSSRH 1339
Query: 201 KINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVKRMETYQKKK 260
+L RE +++ E + + K +E AQ T ++R E ++ K
Sbjct: 1340 DCDLLREQYEEEQEGKAELQRALSKANSE--------VAQWRTKYETDAIQRTEELEEAK 1391
Query: 261 ELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCF 320
+ KL ++ +E V N + A L ++ + + EV +L D+ +
Sbjct: 1392 K--KLAQRLQDSEEQVEAV-------NAKCASLEKTKQRLQGEVEDLMVDVERANSLAAA 1442
Query: 321 FTDNKEKLDDI----------SNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQ 370
+ D + S E L + + L L + Y++ ++++T+ R+
Sbjct: 1443 LDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRE 1502
Query: 371 YKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLITLQELQQAT 430
K + E+E A L +Q EN K + + + S+K+++++ + L L++A
Sbjct: 1503 NKNL--EQEIADLTEQIA--ENGKTIHELEK-----SRKQIELEKADIQLA----LEEAE 1549
Query: 431 KTVYQQQIKILSANLERESQRCVITQWKMACLRK--KHARWTAKIKAEIQAITEKIQNAE 488
+ ++ KIL LE +TQ K RK + ++K Q E +Q+A
Sbjct: 1550 AALEHEEAKILRIQLE-------LTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSAL 1602
Query: 489 VRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSKYEEIFVKET 548
+ NE ++++ G + +IE + + + + + +L +
Sbjct: 1603 DAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDAL 1662
Query: 549 QINKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHIFLFTRDFS 608
+ ++ +E+L + + + E +E R LE+ QE N + L +
Sbjct: 1663 RGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNT 1722
Query: 609 RYISNMEDVKQELQQLRDQESKKNKDHFETLKNLENGFYINDQKADLLLLENKKLKEYIL 668
I + ++ +L QL+ + ++D +N E +K K+ I
Sbjct: 1723 SLIHTKKKLETDLMQLQSEVEDASRD----ARNAE-----------------EKAKKAIT 1761
Query: 669 YLKNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTTVKILVDNGEETLQDIN 728
E+ ++ Q+ TS L R E KDL ++ + G++ +Q
Sbjct: 1762 DAAMMAEELKKEQD----TSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQ--- 1814
Query: 729 NLTDKLRERDEKMQHVSTWLRGSLEGLRLLVEQESPMDLLSKQQLRALL 777
L ++RE + +++ S++GLR + + S++ + +L
Sbjct: 1815 KLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVL 1863
Score = 40.0 bits (92), Expect = 0.009
Identities = 59/290 (20%), Positives = 123/290 (42%), Gaps = 34/290 (11%)
Query: 471 AKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKE 530
A +K E Q +++ +E +R EL + QE + Q++ + L + E+ +
Sbjct: 851 ATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEE----RC 906
Query: 531 KMLMKELSKYE-EIFVKETQINKEKEEEL-VEYLPQLQVAEQEYKEKRRKLEELSNIITA 588
L+K +K++ E +KE E EEE+ E + + E E E ++ +++L +
Sbjct: 907 DQLIK--AKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAK 964
Query: 589 QRQEEDLLNNH--------------IFLFTRDFSRYISNMEDVKQELQQLRDQESKKNKD 634
+E+ N I TR+ + +LQ D+ + NK
Sbjct: 965 VEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKT 1024
Query: 635 HFETLKNLENGFYINDQKADLLLLENKKLKEYILYLKNNIE-KYREGQEALMHTSNDLSR 693
+ + +E+ + L + KKL+ + K +E + QE+++ ND +
Sbjct: 1025 KSKLEQQVED--------LESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLEND--K 1074
Query: 694 QLIAQEAQYKDL-WAEFQTTVKILVDNGEETLQDINNLTDKLRERDEKMQ 742
Q + + + KD + + Q+ V+ G + + I L ++ E +E+++
Sbjct: 1075 QQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIE 1124
Score = 39.7 bits (91), Expect = 0.012
Identities = 71/310 (22%), Positives = 117/310 (37%), Gaps = 78/310 (25%)
Query: 47 EQLFVVEQS---LQSDYFKCNEEAKIFLKDIAVAVKKLEEM---RKATIDLLEIESMELN 100
EQL +VE+ LQ++ EE + L+ A K E+ + LL ++ L
Sbjct: 1670 EQLAIVERRANLLQAEV----EELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLI 1725
Query: 101 KLYYLLETLPNSIKRELEECVRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYN 160
LET ++ E+E+ RDAR N E KK ITD
Sbjct: 1726 HTKKKLETDLMQLQSEVEDASRDAR------------------NAEEKAKKAITDAAMMA 1767
Query: 161 EALGEKQEELARKHARFVLSLNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAE 220
E L +K+++ + R +L QT++ LQ + + EAE
Sbjct: 1768 EEL-KKEQDTSAHLERMKKNLEQTVKD-----------------------LQHR-LDEAE 1802
Query: 221 ELMEK------ERAEYLIRKQELTAQINEFENTREVKRMETYQKK-KEL----------- 262
+L K ++ E IR+ E + + +NT VK + Y+++ KEL
Sbjct: 1803 QLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNV 1862
Query: 263 -------DKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILE 315
DKLQ K+ K + + H + + + E+ + + L
Sbjct: 1863 LRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAESQVNKLR 1922
Query: 316 AKLCFFTDNK 325
AK FT ++
Sbjct: 1923 AKTRDFTSSR 1932
Score = 37.4 bits (85), Expect = 0.057
Identities = 48/203 (23%), Positives = 84/203 (41%), Gaps = 27/203 (13%)
Query: 46 LEQLFVVEQSLQSDYFKCNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKLYYL 105
L QL + D E+AK + D A+ EE++K +E M+ N
Sbjct: 1735 LMQLQSEVEDASRDARNAEEKAKKAITDAAMMA---EELKKEQDTSAHLERMKKN----- 1786
Query: 106 LETLPNSIKRELEECVRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEALGE 165
LE ++ L+E + A + +I ++ RI E E+E +KK T+ K
Sbjct: 1787 LEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKG------ 1840
Query: 166 KQEELARKHARFVLSLNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEE---- 221
RK+ R V L E+ + + + K+ +K + K+ +EA+E
Sbjct: 1841 -----LRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVK---VKSYKRQAEEADEQANA 1892
Query: 222 -LMEKERAEYLIRKQELTAQINE 243
L + +A++ + + E A I E
Sbjct: 1893 HLTKFRKAQHELEEAEERADIAE 1915
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.129 0.341
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,396,622
Number of Sequences: 37866
Number of extensions: 1170555
Number of successful extensions: 12973
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 227
Number of HSP's successfully gapped in prelim test: 1082
Number of HSP's that attempted gapping in prelim test: 6029
Number of HSP's gapped (non-prelim): 4123
length of query: 828
length of database: 18,247,518
effective HSP length: 111
effective length of query: 717
effective length of database: 14,044,392
effective search space: 10069829064
effective search space used: 10069829064
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.