Guide to the Human Genome
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Search of human proteins with 169207319

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|169207319 PREDICTED: hypothetical protein [Homo sapiens]
         (828 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|169207319 PREDICTED: hypothetical protein [Homo sapiens]          1596   0.0  
gi|169207756 PREDICTED: hypothetical protein [Homo sapiens]          1594   0.0  
gi|169207046 PREDICTED: hypothetical protein [Homo sapiens]          1594   0.0  
gi|55770834 centromere protein F [Homo sapiens]                       105   2e-22
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]    99   2e-20
gi|71061468 centromere protein E [Homo sapiens]                        98   4e-20
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li...    96   1e-19
gi|21735548 centrosomal protein 2 [Homo sapiens]                       96   1e-19
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa...    96   1e-19
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]         96   2e-19
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]         96   2e-19
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s...    95   2e-19
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]     95   3e-19
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa...    94   7e-19
gi|156104908 myosin heavy chain 6 [Homo sapiens]                       94   7e-19
gi|33946313 ninein isoform 4 [Homo sapiens]                            94   7e-19
gi|33946321 ninein isoform 5 [Homo sapiens]                            94   7e-19
gi|148536871 ninein isoform 1 [Homo sapiens]                           94   7e-19
gi|148536869 ninein isoform 2 [Homo sapiens]                           94   7e-19
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li...    93   1e-18
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]    92   2e-18
gi|221219020 NYD-SP11 protein [Homo sapiens]                           92   2e-18
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap...    92   3e-18
gi|118498356 kinectin 1 isoform a [Homo sapiens]                       91   6e-18
gi|33620775 kinectin 1 isoform a [Homo sapiens]                        91   6e-18
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]                   91   6e-18
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]     90   7e-18
gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]    90   1e-17
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo...    90   1e-17
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H...    89   2e-17

>gi|169207319 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 828

 Score = 1596 bits (4132), Expect = 0.0
 Identities = 828/828 (100%), Positives = 828/828 (100%)

Query: 1   MALSPWTPGLGAGEKLVQAAAVSTGPSLELCTLPSTLGSSVAVEALEQLFVVEQSLQSDY 60
           MALSPWTPGLGAGEKLVQAAAVSTGPSLELCTLPSTLGSSVAVEALEQLFVVEQSLQSDY
Sbjct: 1   MALSPWTPGLGAGEKLVQAAAVSTGPSLELCTLPSTLGSSVAVEALEQLFVVEQSLQSDY 60

Query: 61  FKCNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEEC 120
           FKCNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEEC
Sbjct: 61  FKCNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEEC 120

Query: 121 VRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFVLS 180
           VRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFVLS
Sbjct: 121 VRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFVLS 180

Query: 181 LNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQ 240
           LNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQ
Sbjct: 181 LNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQ 240

Query: 241 INEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYW 300
           INEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYW
Sbjct: 241 INEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYW 300

Query: 301 EQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDL 360
           EQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDL
Sbjct: 301 EQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDL 360

Query: 361 REKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGL 420
           REKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGL
Sbjct: 361 REKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGL 420

Query: 421 ITLQELQQATKTVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAI 480
           ITLQELQQATKTVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAI
Sbjct: 421 ITLQELQQATKTVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAI 480

Query: 481 TEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSKY 540
           TEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSKY
Sbjct: 481 TEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSKY 540

Query: 541 EEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHI 600
           EEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHI
Sbjct: 541 EEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHI 600

Query: 601 FLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNLENGFYINDQKADLLLLEN 660
           FLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNLENGFYINDQKADLLLLEN
Sbjct: 601 FLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNLENGFYINDQKADLLLLEN 660

Query: 661 KKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTTVKILVDNG 720
           KKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTTVKILVDNG
Sbjct: 661 KKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTTVKILVDNG 720

Query: 721 EETLQDINNLTDKLRERDEKMQHVSTWLRGSLEGLRLLVEQESPMDLLSKQQLRALLVTS 780
           EETLQDINNLTDKLRERDEKMQHVSTWLRGSLEGLRLLVEQESPMDLLSKQQLRALLVTS
Sbjct: 721 EETLQDINNLTDKLRERDEKMQHVSTWLRGSLEGLRLLVEQESPMDLLSKQQLRALLVTS 780

Query: 781 KEEKTCQLSDLVIPNYATNIQLNIDTYLGLNTLVVLSNSAFHLREFSR 828
           KEEKTCQLSDLVIPNYATNIQLNIDTYLGLNTLVVLSNSAFHLREFSR
Sbjct: 781 KEEKTCQLSDLVIPNYATNIQLNIDTYLGLNTLVVLSNSAFHLREFSR 828


>gi|169207756 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 828

 Score = 1594 bits (4127), Expect = 0.0
 Identities = 827/828 (99%), Positives = 828/828 (100%)

Query: 1   MALSPWTPGLGAGEKLVQAAAVSTGPSLELCTLPSTLGSSVAVEALEQLFVVEQSLQSDY 60
           MALSPWTPGLGAGEKLVQAAAVSTGPSLELCTLPSTLGSSVAVEALEQLFVVEQSLQSDY
Sbjct: 1   MALSPWTPGLGAGEKLVQAAAVSTGPSLELCTLPSTLGSSVAVEALEQLFVVEQSLQSDY 60

Query: 61  FKCNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEEC 120
           FKCNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEEC
Sbjct: 61  FKCNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEEC 120

Query: 121 VRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFVLS 180
           VRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFVLS
Sbjct: 121 VRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFVLS 180

Query: 181 LNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQ 240
           LNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQ
Sbjct: 181 LNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQ 240

Query: 241 INEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYW 300
           INEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYW
Sbjct: 241 INEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYW 300

Query: 301 EQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDL 360
           EQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDL
Sbjct: 301 EQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDL 360

Query: 361 REKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGL 420
           REKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGL
Sbjct: 361 REKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGL 420

Query: 421 ITLQELQQATKTVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAI 480
           ITLQELQQATKTVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAI
Sbjct: 421 ITLQELQQATKTVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAI 480

Query: 481 TEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSKY 540
           TEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSKY
Sbjct: 481 TEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSKY 540

Query: 541 EEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHI 600
           EEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHI
Sbjct: 541 EEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHI 600

Query: 601 FLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNLENGFYINDQKADLLLLEN 660
           FLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNLENGFYINDQKADLLLLEN
Sbjct: 601 FLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNLENGFYINDQKADLLLLEN 660

Query: 661 KKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTTVKILVDNG 720
           KKLKEYILYLKNNIEKYREGQEALMHTS+DLSRQLIAQEAQYKDLWAEFQTTVKILVDNG
Sbjct: 661 KKLKEYILYLKNNIEKYREGQEALMHTSSDLSRQLIAQEAQYKDLWAEFQTTVKILVDNG 720

Query: 721 EETLQDINNLTDKLRERDEKMQHVSTWLRGSLEGLRLLVEQESPMDLLSKQQLRALLVTS 780
           EETLQDINNLTDKLRERDEKMQHVSTWLRGSLEGLRLLVEQESPMDLLSKQQLRALLVTS
Sbjct: 721 EETLQDINNLTDKLRERDEKMQHVSTWLRGSLEGLRLLVEQESPMDLLSKQQLRALLVTS 780

Query: 781 KEEKTCQLSDLVIPNYATNIQLNIDTYLGLNTLVVLSNSAFHLREFSR 828
           KEEKTCQLSDLVIPNYATNIQLNIDTYLGLNTLVVLSNSAFHLREFSR
Sbjct: 781 KEEKTCQLSDLVIPNYATNIQLNIDTYLGLNTLVVLSNSAFHLREFSR 828


>gi|169207046 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 828

 Score = 1594 bits (4127), Expect = 0.0
 Identities = 827/828 (99%), Positives = 828/828 (100%)

Query: 1   MALSPWTPGLGAGEKLVQAAAVSTGPSLELCTLPSTLGSSVAVEALEQLFVVEQSLQSDY 60
           MALSPWTPGLGAGEKLVQAAAVSTGPSLELCTLPSTLGSSVAVEALEQLFVVEQSLQSDY
Sbjct: 1   MALSPWTPGLGAGEKLVQAAAVSTGPSLELCTLPSTLGSSVAVEALEQLFVVEQSLQSDY 60

Query: 61  FKCNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEEC 120
           FKCNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEEC
Sbjct: 61  FKCNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEEC 120

Query: 121 VRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFVLS 180
           VRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFVLS
Sbjct: 121 VRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFVLS 180

Query: 181 LNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQ 240
           LNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQ
Sbjct: 181 LNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQ 240

Query: 241 INEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYW 300
           INEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYW
Sbjct: 241 INEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYW 300

Query: 301 EQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDL 360
           EQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDL
Sbjct: 301 EQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDL 360

Query: 361 REKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGL 420
           REKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGL
Sbjct: 361 REKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGL 420

Query: 421 ITLQELQQATKTVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAI 480
           ITLQELQQATKTVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAI
Sbjct: 421 ITLQELQQATKTVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAI 480

Query: 481 TEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSKY 540
           TEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSKY
Sbjct: 481 TEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSKY 540

Query: 541 EEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHI 600
           EEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHI
Sbjct: 541 EEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHI 600

Query: 601 FLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNLENGFYINDQKADLLLLEN 660
           FLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNLENGFYINDQKADLLLLEN
Sbjct: 601 FLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNLENGFYINDQKADLLLLEN 660

Query: 661 KKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTTVKILVDNG 720
           KKLKEYILYLKNNIEKYREGQEALMHTS+DLSRQLIAQEAQYKDLWAEFQTTVKILVDNG
Sbjct: 661 KKLKEYILYLKNNIEKYREGQEALMHTSSDLSRQLIAQEAQYKDLWAEFQTTVKILVDNG 720

Query: 721 EETLQDINNLTDKLRERDEKMQHVSTWLRGSLEGLRLLVEQESPMDLLSKQQLRALLVTS 780
           EETLQDINNLTDKLRERDEKMQHVSTWLRGSLEGLRLLVEQESPMDLLSKQQLRALLVTS
Sbjct: 721 EETLQDINNLTDKLRERDEKMQHVSTWLRGSLEGLRLLVEQESPMDLLSKQQLRALLVTS 780

Query: 781 KEEKTCQLSDLVIPNYATNIQLNIDTYLGLNTLVVLSNSAFHLREFSR 828
           KEEKTCQLSDLVIPNYATNIQLNIDTYLGLNTLVVLSNSAFHLREFSR
Sbjct: 781 KEEKTCQLSDLVIPNYATNIQLNIDTYLGLNTLVVLSNSAFHLREFSR 828


>gi|55770834 centromere protein F [Homo sapiens]
          Length = 3114

 Score =  105 bits (262), Expect = 2e-22
 Identities = 160/740 (21%), Positives = 320/740 (43%), Gaps = 87/740 (11%)

Query: 79   KKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEECVRDARRLNLFEINTIKMR 138
            ++LE  +   +  +++   E+ +   LL+TL + +   L++      +L   E ++  + 
Sbjct: 1989 QELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALS 2048

Query: 139  ITRTE--NEIELLKKKITDLTKYNEALGEKQEELARKHARFVLSLNQTMEKKATTTVYIN 196
            +T+ E  N+I  L K+   L K +E+L  +  E   +      +L   + +K    + ++
Sbjct: 2049 LTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLS 2108

Query: 197  ETYTKINLKREDI--------ALQKKCIQEAEELMEKERAEYLIRK--QELTAQINEFEN 246
             T  +++  R  I        A +KK +  AE+L E+ER    ++   + L  ++   E 
Sbjct: 2109 STQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEE 2168

Query: 247  TREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSE 306
             +E+  ++    K E++ L+T++ ++  ++ V    L     E   L + I+  + ++SE
Sbjct: 2169 NQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSE 2228

Query: 307  LKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKT 366
            L K L+  ++ L    + KE+ +    +E        K  VE L   + + K+L E +  
Sbjct: 2229 LDKLLSSFKSLL----EEKEQAEIQIKEES-------KTAVEML---QNQLKELNEAVAA 2274

Query: 367  LARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLITLQEL 426
            L    +I+ + E+        I +E+Q + +     E   ++   D K     L  LQ+L
Sbjct: 2275 LCGDQEIMKATEQSL---DPPIEEEHQLRNSI----EKLRARLEADEKKQ---LCVLQQL 2324

Query: 427  QQATKTVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAITEKIQN 486
            +++    +   +K    NLERE +     Q   A   +        +KA+I+ +T+ ++ 
Sbjct: 2325 KESEH--HADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRG 2382

Query: 487  AEV-------RRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSK 539
             E+        +  L NE    Q+ IS            L+E+E+     EK+ MKE S 
Sbjct: 2383 LELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQ-----EKVQMKEKSS 2437

Query: 540  YEEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQE-----ED 594
               + + +TQ+     +EL E +  L   ++  K K + L      +  ++ +     ++
Sbjct: 2438 -TAMEMLQTQL-----KELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDE 2491

Query: 595  LLNNHIFLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNLENGFYINDQKAD 654
              NN+I L +   +  I  +ED KQ+L++ +D+E  + K+  +  + L +       K  
Sbjct: 2492 AKNNYIVLQS-SVNGLIQEVEDGKQKLEK-KDEEISRLKNQIQDQEQLVS-------KLS 2542

Query: 655  LLLLENKKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTT-- 712
             +  E++  KE  L L+N   +  +  + L   +  L   L   ++ YK+L  E + T  
Sbjct: 2543 QVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKM 2602

Query: 713  --------VKILVDNGEETLQDINNLTDKLRERDEKMQHVSTWLRGSLEGLRLLVEQESP 764
                    V  +     E  ++++ +  K  E  E++      L G L+   LL+E+   
Sbjct: 2603 DKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQ---LLLEEIKS 2659

Query: 765  MDLLSKQQLRALLVTSKEEK 784
                SK QL+ L + + E K
Sbjct: 2660 ----SKDQLKELTLENSELK 2675



 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 103/528 (19%), Positives = 243/528 (46%), Gaps = 71/528 (13%)

Query: 71   LKDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEECVR------DA 124
            L+ + + V  +   ++   + L+ E   +++L  +  +  N ++ + +E V+       A
Sbjct: 2380 LRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTA 2439

Query: 125  RRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELAR-----KHARFVL 179
              +   ++  +  R+    N+ E  K K  +L+   E L  ++ +L +     K+   VL
Sbjct: 2440 MEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVL 2499

Query: 180  --SLNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQEL 237
              S+N  +++       + +   K+  K E+I+  K  IQ+ E+L+ K      + + E 
Sbjct: 2500 QSSVNGLIQE-------VEDGKQKLEKKDEEISRLKNQIQDQEQLVSK------LSQVEG 2546

Query: 238  TAQINEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTV--SAAVLSDHNLEIARLHE 295
              Q+ + +N  E++ + T + ++++  LQ+K + +++T+ V  S+    ++ LE+ ++ +
Sbjct: 2547 EHQLWKEQNL-ELRNL-TVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDK 2604

Query: 296  SIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARM 355
                + ++V+++      L+ ++        +L +  + EKN    +++ L+E + +++ 
Sbjct: 2605 MS--FVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKD 2662

Query: 356  EYKDL---------------------REKMKTLARQYKIVLSEEEKA----FLQKQKIHD 390
            + K+L                       K++    +Y++ L E EK      L   K ++
Sbjct: 2663 QLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYE 2722

Query: 391  -ENQKQLTFISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSANLERES 449
             E Q     ++ KE  LS ++++I  ++     L    +AT  + ++  K    NL+  +
Sbjct: 2723 VEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVN 2782

Query: 450  QRCVITQWKMACLRKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFV 509
            Q           L+K++ R   K+K  I++  +  +  E+ + EL    + ++++ +G V
Sbjct: 2783 Q-----------LKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTV 2831

Query: 510  --AQIEKLTTELKEEEKAFVNKEKMLMKELSKYEEIFVKETQINKEKE 555
               ++++LTTE+KE ++    K K   + L KY  + +   ++ K KE
Sbjct: 2832 MDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKE 2879



 Score = 77.0 bits (188), Expect = 7e-14
 Identities = 140/724 (19%), Positives = 301/724 (41%), Gaps = 104/724 (14%)

Query: 44   EALEQLFVVEQSLQSDYFKCNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKLY 103
            E L +    +Q   S+  K     K  L++   A  +++E  K  +++L+ +  ELN+  
Sbjct: 2213 ENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAV 2272

Query: 104  YLL---ETLPNSIKRELEECVRDARRLNLFEINTIKMRITRTENE----IELLKKKI--T 154
              L   + +  + ++ L+  + +  +L    I  ++ R+   E +    ++ LK+     
Sbjct: 2273 AALCGDQEIMKATEQSLDPPIEEEHQLRN-SIEKLRARLEADEKKQLCVLQQLKESEHHA 2331

Query: 155  DLTKYNEALGEKQEELARKHARFVLSLNQTMEKKATTTVYINETYTKINLKREDIALQKK 214
            DL K      E++ E+AR +        +  + +  T     E  T+       + L   
Sbjct: 2332 DLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQ---SLRGLELDVV 2388

Query: 215  CIQEAEELMEKERAEYLIRKQELTAQINEFENTREVKRMETYQKKKE----LDKLQTKMS 270
             I+  +E +  E  +   R  EL    + FEN  + K  E  Q K++    ++ LQT++ 
Sbjct: 2389 TIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLK 2448

Query: 271  KIKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDD 330
            ++ E V   AA+ +D         E+ +  EQ +S   + L + +A+L    D       
Sbjct: 2449 ELNERV---AALHNDQ--------EACKAKEQNLSSQVECLELEKAQLLQGLD------- 2490

Query: 331  ISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHD 390
               + KN ++     L  +++    E +D ++K++           ++E+    K +I D
Sbjct: 2491 ---EAKNNYI----VLQSSVNGLIQEVEDGKQKLE----------KKDEEISRLKNQIQD 2533

Query: 391  ENQ--KQLTFISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSANLERE 448
            + Q   +L+ +  +     ++ ++++N+   L    ++ Q+     Q  +++L ++ +  
Sbjct: 2534 QEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNL 2593

Query: 449  SQRCVITQWKMACLRKKHARWTAK---IKAEIQAITEKIQNAEVR----RIELLNETSFR 501
                 +T+       +K  + TAK   ++ E+  + +K    +      +  L  E    
Sbjct: 2594 ENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLL 2653

Query: 502  QQEISGFVAQIEKLTTELKEEEKAF-------VNKEKMLMKELSKYEEIFVKETQINKEK 554
             +EI     Q+++LT E  E +K+        V KE  + +E+++Y+   ++  +  K+ 
Sbjct: 2654 LEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQ---LRLHEAEKKH 2710

Query: 555  EEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLL-------NNHIFLFTR-- 605
            +  L++   Q +V  Q Y+EK    EE    +++Q+ E DLL       NN +   T+  
Sbjct: 2711 QALLLDTNKQYEVEIQTYREKLTSKEEC---LSSQKLEIDLLKSSKEELNNSLKATTQIL 2767

Query: 606  --------DFSRYISNMEDVKQELQ-----------QLRDQES--KKNKDHFETLKNLEN 644
                    D  +Y++ ++   +  Q           QL +++   +K     +  +  + 
Sbjct: 2768 EELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQK 2827

Query: 645  GFYINDQKADLLLLENKKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKD 704
               + D K D L  E K+LKE +       ++Y +   +L+ +   L +     E Q   
Sbjct: 2828 TGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAH 2887

Query: 705  LWAE 708
            L ++
Sbjct: 2888 LCSQ 2891



 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 145/771 (18%), Positives = 310/771 (40%), Gaps = 115/771 (14%)

Query: 44  EALEQLFVVEQSLQSDYFKCNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKLY 103
           +A   +F  +Q     +   N +     +D + +    E+    +   L+I   + N  +
Sbjct: 211 QASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSF 270

Query: 104 YLLETLPNSIKRELEECVRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEAL 163
           +   + P+ +  +L+   ++ R     +IN +++R+   E E   +K ++    +    L
Sbjct: 271 FDNSSSPHLLD-QLKAQNQELRN----KINELELRLQGHEKE---MKGQVNKFQELQLQL 322

Query: 164 GEKQEELARKHARFVLSLNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELM 223
            + + EL  K       LN+  ++   TT   ++  TK        AL++K  +  E+L 
Sbjct: 323 EKAKVELIEKEK----VLNKCRDELVRTTAQYDQASTKYT------ALEQKLKKLTEDL- 371

Query: 224 EKERAEYLIRKQELTAQINEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVL 283
                         + Q    E+ R     +  +K+KE  +  ++  +  +T+      +
Sbjct: 372 --------------SCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQM 417

Query: 284 SDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKI 343
                  ARL        QE+ + K    +L+A+L   T  K++L++       EF  K+
Sbjct: 418 K------ARL-------TQELQQAKNMHNVLQAELDKLTSVKQQLEN----NLEEFKQKL 460

Query: 344 KQLVETLHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKE 403
            +  +   A++++  +LR  M+ + ++  ++ S  E+   +   +  E +     ++Q +
Sbjct: 461 CRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQ 520

Query: 404 YFLSQKRVDIKNMEEGLITLQE-LQQATKTVYQQQIKILSANLERESQRCVITQWKMACL 462
            F  + +    + E  L  LQE + Q   ++  +++K+  A+LE++             L
Sbjct: 521 NFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQ------RDCSQDLL 574

Query: 463 RKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEE 522
           +K+        +  I+ + +K+   E     LL+    +++E             ELKEE
Sbjct: 575 KKR--------EHHIEQLNDKLSKTEKESKALLSALELKKKEYE-----------ELKEE 615

Query: 523 EKAF----VNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRK 578
           +  F       EK+L +  S+ E +        + K   L   L   Q+   EY E+ R 
Sbjct: 616 KTLFSCWKSENEKLLTQMESEKENL--------QSKINHLETCLKTQQIKSHEYNERVRT 667

Query: 579 LEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFET 638
           LE     +  +    ++ N H  L ++  S  +   +    ELQQ  +   +K++   E 
Sbjct: 668 LE-----MDRENLSVEIRNLHNVLDSK--SVEVETQKLAYMELQQKAEFSDQKHQKEIEN 720

Query: 639 --LKNLENGFYINDQKADLLLLENKKLKEYILY--LKNNIEKYRE---GQEALMHTSNDL 691
             LK  +    + D +  L LL N+ + +   Y  L    E  R+    ++A + T+ D 
Sbjct: 721 MCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDH 780

Query: 692 SRQLIAQEAQ------YKDLWAE------FQTTVKILVDNGEETLQDINNLTDKLRERDE 739
            R L+A + Q      + ++  E       ++  ++  D   +    + N  D L    E
Sbjct: 781 QRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLE 840

Query: 740 KMQHVSTWLRGSLEGLRLLVEQESPMDLLSKQQLRALLVTSKEEKTCQLSD 790
             + +++ L+   E L + ++ E   +L+  +Q+    V    ++  +L +
Sbjct: 841 SQKQMNSDLQKQCEEL-VQIKGEIEENLMKAEQMHQSFVAETSQRISKLQE 890



 Score = 71.2 bits (173), Expect = 4e-12
 Identities = 93/544 (17%), Positives = 238/544 (43%), Gaps = 38/544 (6%)

Query: 112  SIKRELEECVRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELA 171
            ++K ++E   +  R L L ++ TI+       NE++  +++I++L   N +     +E  
Sbjct: 2368 TLKAKIEGMTQSLRGLEL-DVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKE 2426

Query: 172  RKHARFVLSLNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKERAEYL 231
            ++  +     +  ME   T    +NE    ++  +E    +++ +    E +E E+A+ L
Sbjct: 2427 QEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLL 2486

Query: 232  IRKQELTAQINEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIA 291
                E        +++      E    K++L+K   ++S++K  +     ++S    +++
Sbjct: 2487 QGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVS----KLS 2542

Query: 292  RLHESIRYWEQE-------VSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEF-LNKI 343
            ++    + W+++         EL++ + +L++K     D  E L     + +NE  L K+
Sbjct: 2543 QVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKM 2602

Query: 344  KQL--VETLHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQ 401
             ++  VE ++    +  +L+ +M  +A++       +E+   +K ++  E Q  L  I  
Sbjct: 2603 DKMSFVEKVNKMTAKETELQREMHEMAQK---TAELQEELSGEKNRLAGELQLLLEEIKS 2659

Query: 402  KEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSANLERESQRCVITQWKMAC 461
             +  L +  ++   +++ L  + + Q   +   +++I      L    ++        A 
Sbjct: 2660 SKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKK------HQAL 2713

Query: 462  LRKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKE 521
            L   + ++  +I+   + +T K +    +++E+ +     ++E++  +    ++  ELK+
Sbjct: 2714 LLDTNKQYEVEIQTYREKLTSKEECLSSQKLEI-DLLKSSKEELNNSLKATTQILEELKK 2772

Query: 522  EEKAFVNKEKMLMKELSKYE---EIFVKETQINKEKEEELVEYLPQLQVAEQEYK----- 573
             +   +     L KE  + +   ++ +K  +  +E++E L + L QLQ A+++ K     
Sbjct: 2773 TKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVM 2832

Query: 574  -----EKRRKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQQLRDQE 628
                 E   +++EL   +  + +E D   +          +     E ++ ++  L  Q+
Sbjct: 2833 DTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHLCSQQ 2892

Query: 629  SKKN 632
            SK++
Sbjct: 2893 SKQD 2896



 Score = 66.6 bits (161), Expect = 9e-11
 Identities = 160/807 (19%), Positives = 315/807 (39%), Gaps = 129/807 (15%)

Query: 96   SMELNKLYYLLETLPNSIKRELEECVRDARRLNLFEINTIKMRITRTENEIELLKKKITD 155
            S E  +L +++E     ++  L E      +L+L E+  +    T+ E  IEL +K + +
Sbjct: 1780 SNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLM----TKIEACIEL-EKIVGE 1834

Query: 156  LTKYNEALGEKQEELARKHARFVL------SLNQTMEKKA--TTTVYINETYTKIN---- 203
            L K N  L EK E  +  H   +        LN  +E  A  ++   I +   K+N    
Sbjct: 1835 LKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWK 1894

Query: 204  ------------LKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQ--INEFENTRE 249
                        ++ E  +++ + +    +L   +  +  + K     Q  I   E    
Sbjct: 1895 ERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELS 1954

Query: 250  VKRMETYQKKKELD---KLQTKMSKIKETVTVSAAVLSDHN-----------LEIARLHE 295
            V   E  Q + ELD   K  T + ++ E +      L  H             E+    E
Sbjct: 1955 VVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTE 2014

Query: 296  SIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEF--LNKIKQLV----ET 349
             ++    +VSEL KD   L+ KL     + + L     + +N+   LNK K+L+    E+
Sbjct: 2015 LLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESES 2074

Query: 350  LHA--ARMEYKDLREKMKTLAR-----QYKIVLSEEEKAFLQ--------KQKIHDENQK 394
            L A  +  +Y+ L       A      ++ + LS  ++   Q        + +I  + +K
Sbjct: 2075 LQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKK 2134

Query: 395  QLTFISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSANLERESQRCVI 454
            QL  I++K     ++   +K+  E L   +ELQ + +    Q++ IL A   +     + 
Sbjct: 2135 QL-HIAEKLKERERENDSLKDKVENLE--RELQMSEEN---QELVILDAENSKAEVETLK 2188

Query: 455  TQWK-MACLRKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIE 513
            TQ + MA   K        +++E + +T++IQ  + +    L+E           + + E
Sbjct: 2189 TQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQ----LSELDKLLSSFKSLLEEKE 2244

Query: 514  KLTTELKEEEKAFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYK 573
            +   ++KEE K  V   +  +KEL++       + +I K  E+ L   + +        +
Sbjct: 2245 QAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIE 2304

Query: 574  EKRRKLE--ELSNIITAQRQEE-----DLLNNHIFLFTRDFSRYISNM-------EDVKQ 619
            + R +LE  E   +   Q+ +E     DLL   +    R+     +N        E+ K 
Sbjct: 2305 KLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKG 2364

Query: 620  ELQQLR---------------------------DQESKKNKDHFETLKNLENGF--YIND 650
            E++ L+                             E +K ++    L+ + + F   + +
Sbjct: 2365 EVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQE 2424

Query: 651  QKADLLLLENKK------LKEYILYLKNNIEKYREGQEALMHTSNDLSRQ---LIAQEAQ 701
            ++ + + ++ K       L+  +  L   +      QEA      +LS Q   L  ++AQ
Sbjct: 2425 KEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQ 2484

Query: 702  YKDLWAEFQTTVKILVDNGEETLQDINNLTDKLRERDEKMQHVSTWLRGSLEGLRLLVEQ 761
                  E +    +L  +    +Q++ +   KL ++DE++  +   ++   + +  L + 
Sbjct: 2485 LLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQV 2544

Query: 762  ESPMDLLSKQQLRALLVTSKEEKTCQL 788
            E    L  +Q L    +T + E+  Q+
Sbjct: 2545 EGEHQLWKEQNLELRNLTVELEQKIQV 2571



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 106/527 (20%), Positives = 215/527 (40%), Gaps = 48/527 (9%)

Query: 223  MEKERAEYLIRKQELTAQINEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAV 282
            ++K+  E +  K E+   + + E   +    ET Q+   + KLQ   S  +  V  + + 
Sbjct: 849  LQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQR---ISKLQEDTSAHQNVVAETLSA 905

Query: 283  LSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNK 342
            L +   E+  L++ +   + E+ ELKK   +LE  L       + L +  + EK      
Sbjct: 906  LENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSL----KELQLLSETLSLEK------ 955

Query: 343  IKQLVETLHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQK 402
             K++   +   + E ++L ++  TL ++    L++E+   +QK      ++    +I ++
Sbjct: 956  -KEMSSIISLNKREIEELTQENGTL-KEINASLNQEKMNLIQK------SESFANYIDER 1007

Query: 403  EYFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSANLERESQRCVITQWKMACL 462
            E  +S+     K  +E LI LQ  ++          K  +A  +     C++ +    C 
Sbjct: 1008 EKSISELSDQYK--QEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCE 1065

Query: 463  RKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEE 522
             +K+         E++ + E          E L + +F ++     + ++E +   L+ E
Sbjct: 1066 NRKN---------ELEQLKEAFAK---EHQEFLTKLAFAEERNQNLMLELETVQQALRSE 1113

Query: 523  EKAFVNKEKMLMKELSKYEEIFVKETQ--INKEKEEELVEYLPQLQVAEQEYKEKRRKLE 580
                 N  K     L K E + +KE Q  + KE  + L E    ++V + +++ +  + E
Sbjct: 1114 MTDNQNNSKSEAGGL-KQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESE 1172

Query: 581  ELSNIITAQRQEEDLLN--NHIFLFTRDFSRYISNMEDVKQEL----QQLRDQESKKNKD 634
             + N +  +  E +  N    + L  ++ S    N + V+ E     ++L+ QES+K K+
Sbjct: 1173 PIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKE 1232

Query: 635  HFETLKNLENGFYINDQKADLLLLENKKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQ 694
              +       G        D+   E   LK+  +  +   EKY  G   L  + ND +  
Sbjct: 1233 CLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAE---EKYISGPHELSTSQNDNAHL 1289

Query: 695  LIAQEAQYKDLWAEFQTTVKILVDNGEETLQDINNLTDKLRERDEKM 741
              + +     L  E +   +IL     E + ++N+   +      KM
Sbjct: 1290 QCSLQTTMNKL-NELEKICEILQAEKYELVTELNDSRSECITATRKM 1335



 Score = 57.0 bits (136), Expect = 7e-08
 Identities = 134/718 (18%), Positives = 297/718 (41%), Gaps = 62/718 (8%)

Query: 99   LNKLYYLLETLPNSIKRELEECVRDARRLNLFEINTIKMRITRTENEIELLKKK-ITDLT 157
            + +L  L E    S+++ LEE +     +   EI  ++  ++    E++ L+K+ +++  
Sbjct: 1549 VEELESLCEVYRQSLEK-LEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENE 1607

Query: 158  KYNEALGEKQEELARKHARFVLSLNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQ 217
            ++ + L     E+  K A          EKK T  + +     ++ L+  D++ +     
Sbjct: 1608 QWQQKLTSVTLEMESKLAA---------EKKQTEQLSLELEVARLQLQGLDLSSRSLLGI 1658

Query: 218  EAEELMEKERAEYLIRKQELTAQINEFENTREVKRMETYQKKKELD---KLQTKMSKIKE 274
            + E+ ++       I K+  T++  E     +V ++     +++L+   +  T+   +K 
Sbjct: 1659 DTEDAIQGRNESCDISKEH-TSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKP 1717

Query: 275  TVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISND 334
            T   S     D N E     ++     Q  SE   +L+          D     +DI N 
Sbjct: 1718 TGECSGEQSPDTNYEPPGEDKT-----QGSSECISELSFSGPNALVPMDFLGNQEDIHNL 1772

Query: 335  EKN--EFLNKIKQLVETLHAARMEYKDLREKMKTLARQY---KIVLSEEEKAFLQKQKIH 389
            +    E  N+  +L+  +     + + L  +MK L  +    ++ L  + +A ++ +KI 
Sbjct: 1773 QLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIV 1832

Query: 390  DENQKQLTFISQK-EYFLSQKRVDIKNME--EGLITLQELQQATKTVYQQQIKILSANLE 446
             E +K+ + +S+K EYF    +  ++ +E  EGL +  E+     +       +   N +
Sbjct: 1833 GELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVN-D 1891

Query: 447  RESQRCVITQWKMACLRKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEIS 506
               +R +  + +++ +R + A     I+ E   +   ++  +  ++ L  +   +Q+ I 
Sbjct: 1892 SWKERFLDVENELSRIRSEKA----SIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIV 1947

Query: 507  GFVAQIEKLTTELKEEEKAFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQ 566
                ++  +T+E  +       +   + K+ +  +++  K  +  +E E    E L  +Q
Sbjct: 1948 CLEEELSVVTSERNQLR----GELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQ 2003

Query: 567  VAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQQLRD 626
            VAE E KEK   L+ LS+ ++   +++  L   +    +D         +++ ++ QL  
Sbjct: 2004 VAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNK 2063

Query: 627  QESKKNKDHFETLKNLENGFY--INDQKA-DLLLLEN-------KKLKEYILYLKNNIEK 676
            ++    K+       L    Y  +N  KA +  L+E           +E +  L+  IEK
Sbjct: 2064 EKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEK 2123

Query: 677  YREGQEALMHTSNDLSRQLIAQEAQ---YKDLWAEFQTTVKILVDNGEETLQDINNLTDK 733
             R   EA       ++ +L  +E +    KD     +  +++  +N E  + D  N    
Sbjct: 2124 LRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAEN---- 2179

Query: 734  LRERDEKMQHVSTWLRGSLEGLRLLVEQESPMDLLSKQQLRALLVTSKEEKTCQLSDL 791
                  +++ + T +      L++       +DL++ +  +  L    +EK  QLS+L
Sbjct: 2180 ---SKAEVETLKTQIEEMARSLKVF-----ELDLVTLRSEKENLTKQIQEKQGQLSEL 2229



 Score = 38.1 bits (87), Expect = 0.034
 Identities = 107/605 (17%), Positives = 233/605 (38%), Gaps = 117/605 (19%)

Query: 128  NLFEINTIKMRITRTEN-EIELLKKKITDLTKYNE-ALGEKQEELARKHARFVLSLN--- 182
            N +E  + K +  + +N ++E L  + T L +  +  L + +E  A++H  F+  L    
Sbjct: 1034 NAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAE 1093

Query: 183  ----------QTMEKKATTTVYINETYTK----------INLKREDIALQKKC---IQEA 219
                      +T+++   + +  N+  +K          + LK E   +QK+    +QE 
Sbjct: 1094 ERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQEN 1153

Query: 220  EELMEKERAEYLIRKQELTAQINEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVS 279
            E+LM+  + ++  +  E     N  +     +    ++ + +L+  +  +      +   
Sbjct: 1154 EQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQL 1213

Query: 280  AAVLSDHNLEIARLHESIRYWEQEVSELKKDL-----------AILEAKLC------FFT 322
             A+L +  L++    +     + E+  ++ DL            I   K C       + 
Sbjct: 1214 EAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYI 1273

Query: 323  DNKEKLDDISNDEKN---------EFLNKIKQLVETLHAAR----MEYKDLREKMKTLAR 369
                +L    ND  +           LN+++++ E L A +     E  D R +  T  R
Sbjct: 1274 SGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATR 1333

Query: 370  QY---------KIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGL 420
            +          ++ +  ++   L  + + D    +      +++ +S   +D  N  E L
Sbjct: 1334 KMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHL 1393

Query: 421  -ITLQELQQATKTVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQA 479
             ++ +E+Q     + ++ + + S +     Q C ++  KM+ L+     +   +KAE   
Sbjct: 1394 TLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSS-KMSELQ----TYVDSLKAENLV 1448

Query: 480  ITEKIQNAE---VRRIELLNETSFRQQEISGFVAQIEKLTT-----------ELKEEEKA 525
            ++  ++N +   V+ ++L  E        S  V     L++           E   +   
Sbjct: 1449 LSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSL 1508

Query: 526  FVNKEKMLMKELSKYEEIFV----------KETQINKEKEEELVE-----YLPQLQVAEQ 570
              N E  +       +E+F           KET     K  E +E     Y   L+  E+
Sbjct: 1509 LSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEE 1568

Query: 571  EYKE----KRRKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQQLR- 625
            + +     K ++++EL  +++++RQE D L            +Y+S  E  +Q+L  +  
Sbjct: 1569 KMESQGIMKNKEIQELEQLLSSERQELDCLR----------KQYLSENEQWQQKLTSVTL 1618

Query: 626  DQESK 630
            + ESK
Sbjct: 1619 EMESK 1623


>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
          Length = 1684

 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 179/803 (22%), Positives = 342/803 (42%), Gaps = 100/803 (12%)

Query: 29  ELCTLPSTLGSSVAVEALEQ---LFVVEQ--------SLQSDYFKCNEEAKIFLKDIAVA 77
           EL + P T G+   ++AL +     ++E+        SL+ +  K  +E +  +  +  A
Sbjct: 57  ELRSKPVTEGTGDIIKALTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDA 116

Query: 78  VKKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEECVRDARRLN--LFEINTI 135
            K+LE+     +  +E    EL  +         +++++LEE +     L+  L   N  
Sbjct: 117 HKELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNS 176

Query: 136 KMRITRTENEIELLK----KKITDLTKYNEALGEKQEELARKHARFVLSLNQTMEKKATT 191
           +  + + + EIE ++    ++I  L K  +A  ++++E   +    + + +Q  +K    
Sbjct: 177 EDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKN--- 233

Query: 192 TVYINETYTKINLKREDIALQKKCI--QEAEELMEKERAEYLIRKQELTAQINEFENTRE 249
                     IN  +E++ LQ K I  +E +ELM +  A      +E  A+IN+    +E
Sbjct: 234 ----------INSLQEEL-LQLKAIHQEEVKELMCQIEAS----AKEHEAEINKLNELKE 278

Query: 250 --VKRMETYQK---KK---ELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWE 301
             VK+ E  +K   KK   EL+ L+   S   +   + + +L ++      ++E +++ E
Sbjct: 279 NLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLE 338

Query: 302 QEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQL---VETLHAARMEYK 358
             + EL+   +IL+ ++ +  + K KL+  +   K+EF ++ + L   +  L  A+ E  
Sbjct: 339 DTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQG 398

Query: 359 DLREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEE 418
            + EK+K+            E A L KQ  +   Q      S KE    Q + +I  + E
Sbjct: 399 CVIEKLKS------------ELAGLNKQFCYTVEQHNREVQSLKE----QHQKEISELNE 442

Query: 419 GLITLQELQQATKTVYQQQIKILSANLERESQRCVITQWK----MACLRKKHARWTAKIK 474
             ++  E ++ T     Q +K    NL++E Q  ++        M  L+ +      KI 
Sbjct: 443 TFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKIS 502

Query: 475 AEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLM 534
            E +++ ++ Q ++V  ++    T+F +++     A +E +     E EK    +E  L+
Sbjct: 503 QEFESMKQQ-QASDVHELQQKLRTAFTEKD-----ALLETVNRLQGENEKLLSQQE--LV 554

Query: 535 KELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKL----EELSNIITAQR 590
            EL         E  I   +E+  V YL  L   +   KE   K+    EE  + I   +
Sbjct: 555 PEL---------ENTIKNLQEKNGV-YLLSLSQRDTMLKELEGKINSLTEEKDDFINKLK 604

Query: 591 QEEDLLNNHIFLFTRDFSRYISNMEDVKQELQQLRDQESKKNK---DHFETLKNLENGFY 647
              + ++N      R+    +   + V+Q +Q   + E K N+      ETLK  +    
Sbjct: 605 NSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQ--- 661

Query: 648 INDQKADLLLLENKKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWA 707
            NDQK + L+++ K L E    L   ++   E    L      LSR L    +Q +D+  
Sbjct: 662 -NDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVIL 720

Query: 708 EFQTTVKILVDNGEETLQDINNLTDKLRERDEKMQHVSTWLRGSLEGLRLLVEQES-PMD 766
           +   T   L    +  +++ +NL   L     +   V T L G L+ +   V ++S   D
Sbjct: 721 KEHITQ--LEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKD 778

Query: 767 LLSKQQLRALLVTSKEEKTCQLS 789
           +++  Q     +    E+ C L+
Sbjct: 779 VVNVLQAVGESLAKINEEKCNLA 801



 Score = 93.2 bits (230), Expect = 9e-19
 Identities = 145/691 (20%), Positives = 305/691 (44%), Gaps = 76/691 (10%)

Query: 78   VKKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEECVRDARR-LNLFEINTIK 136
            ++KL    K   +  E+ S E+  LY       N +  E ++  RD    L+  E   +K
Sbjct: 666  LEKLMVQMKVLSEDKEVLSAEVKSLY----EENNKLSSEKKQLSRDLEVFLSQKEDVILK 721

Query: 137  MRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFVL------SLNQTMEKKAT 190
              IT+ E +++L+ ++  +L K  E   E+ ++L  K   +         +++  E+K  
Sbjct: 722  EHITQLEKKLQLMVEEQDNLNKLLE--NEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDV 779

Query: 191  TTVY--INETYTKINLKREDIALQK-KCIQEAEELMEKERAEYLIRKQELTAQINEFENT 247
              V   + E+  KIN ++ ++A Q+ + + E E+ ++  + E +++ +EL + + ++E  
Sbjct: 780  VNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQE 839

Query: 248  REVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEI-----------ARLH-E 295
            + + R E  + + E + LQ+ + ++K     +   L + NL I           + +H E
Sbjct: 840  KVLLRKELEEIQSEKEALQSDLLEMKNANEKTR--LENQNLLIQVEEVSQTCSKSEIHNE 897

Query: 296  SIRYWEQEVSELK-----KDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETL 350
              + + +E   LK     K+L    A+L    D+  K   + ND     L+ +K+L E +
Sbjct: 898  KEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDP----LSSVKELEEKI 953

Query: 351  HAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFI-SQKEYFLSQK 409
                 E K+  EK+  +    K+V  + +K     +K     +++L  + S+K+   +  
Sbjct: 954  ENLEKECKEKEEKINKI----KLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASM 1009

Query: 410  RVDIKNMEEGLITLQELQQATKTV---------YQQQIKILSANLERESQRC--VITQWK 458
            R  I+  E     L E ++ ++ +         ++ +I+ L+  L   + +C  + +  +
Sbjct: 1010 RDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNE 1069

Query: 459  MACLRKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTE 518
                R +  +  AK+  E+Q +  +   A V + EL  E   ++Q+I      + +L   
Sbjct: 1070 DLLARIETLQSNAKL-LEVQILEVQRAKAMVDK-ELEAEKLQKEQKIKEHATTVNEL--- 1124

Query: 519  LKEEEKAFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRK 578
              EE +  + KEK  +++  +  E+  K+ Q       E+ +Y   ++   Q+   K  K
Sbjct: 1125 --EELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNK 1182

Query: 579  LEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQQLRDQ--ESKK-NKDH 635
            +E+L   I  Q+Q+++ L   I        +Y      +KQ L + + +  +SK+   DH
Sbjct: 1183 IEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDH 1242

Query: 636  FETLKNLENGFYINDQKADL-------LLLENKKLKEYILYLKNNIEKYREGQEALMHTS 688
                 +L+     + Q+ ++       +  E  K+ E   +LK + E+++    A     
Sbjct: 1243 LILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHE---HLKTSAEQHQRTLSAYQQRV 1299

Query: 689  NDLSRQLIAQEAQYKDLWAEFQTTVKILVDN 719
              L  +  A +A+   + +EF+ + K+ V N
Sbjct: 1300 TALQEECRAAKAEQATVTSEFE-SYKVRVHN 1329



 Score = 35.4 bits (80), Expect = 0.22
 Identities = 89/517 (17%), Positives = 218/517 (42%), Gaps = 82/517 (15%)

Query: 79   KKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEECVRDARRLNLFEINTIKMR 138
            K+ +E  +  I  L+    +  +    ++ L    K+EL +  + A   +L    ++K  
Sbjct: 1194 KQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADS-KQAETDHLILQASLKGE 1252

Query: 139  ITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFVLSLNQTMEKKATTTVYINET 198
            +  ++ ++E+ K ++ ++T     + E  +  A +H R + +  Q +             
Sbjct: 1253 LEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVT------------ 1300

Query: 199  YTKINLKREDIALQKKC--IQEAEELMEKERAEYLIRKQELTAQINEFENTREVKRMETY 256
                       ALQ++C   +  +  +  E   Y +R   +  Q    +  + + + ET 
Sbjct: 1301 -----------ALQEECRAAKAEQATVTSEFESYKVRVHNVLKQ----QKNKSMSQAETE 1345

Query: 257  QKKKE-------LDKLQTKMSKIKETVTVSAAVL----SDHNLEIARLHESIRYWEQEVS 305
              K+E       +D+L+ K+   +  + ++ + L    S+H+  + R ++ ++    + +
Sbjct: 1346 GAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEA 1405

Query: 306  ELKKDLAILEAK-LCFFTDNKEKLDDISNDE---KNEFLNKIKQLVETLHAARMEYKDLR 361
            EL++ L  ++++ +   +++ + +  +++     +N F ++++ L E          + R
Sbjct: 1406 ELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQE----------EHR 1455

Query: 362  EKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLI 421
            + ++TL +Q    LS+ E A L + K     +  ++     +    ++  D+  ++   +
Sbjct: 1456 KTVETLQQQ----LSKME-AQLFQLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTV 1510

Query: 422  TLQELQQATKTVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKAE--IQA 479
            T +E  +  +T   + +   S   +   Q     + K+     +   W A+   E  +Q 
Sbjct: 1511 TREE-GEGMETTDTESVSSASTYTQSLEQLLNSPETKL-----EPPLWHAEFTKEELVQK 1564

Query: 480  ITEKIQNAE-----VRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLM 534
            ++   ++A+     +R  E  N  +   ++I    ++I +L    +E EK+  N E  L 
Sbjct: 1565 LSSTTKSADHLNGLLRETEATN--AILMEQIKLLKSEIRRLERN-QEREKSAANLE-YLK 1620

Query: 535  KELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQE 571
              L ++  IF+K      E+E  L      LQ++ +E
Sbjct: 1621 NVLLQF--IFLKP---GSERERLLPVINTMLQLSPEE 1652


>gi|71061468 centromere protein E [Homo sapiens]
          Length = 2701

 Score = 97.8 bits (242), Expect = 4e-20
 Identities = 158/757 (20%), Positives = 323/757 (42%), Gaps = 105/757 (13%)

Query: 72   KDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKREL---EECVRDARRLN 128
            +D+  +  KL+E     I +L  E   L  +  + ET     + EL   +   +D+  L 
Sbjct: 1269 QDLEKSHTKLQE----EIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLA 1324

Query: 129  LFEINTIKM--RITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFVLSLNQTME 186
              E+  +++  +   ++ EI+ L K+  +L    EAL  K ++L ++H R  L+  Q  +
Sbjct: 1325 RIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQL-KEHIRETLAKIQESQ 1383

Query: 187  KKATTTVYI----NETYTKINLKREDIALQKKCIQEAEELM---EKERAEYLIRKQELTA 239
             K   ++ +    NET TKI  + E    +   +   E  M    K   E     + +  
Sbjct: 1384 SKQEQSLNMKEKDNET-TKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAK 1442

Query: 240  QINEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRY 299
            + ++ +  +EV + E+ Q K+ + ++  K  + +E + V+   L +    I  L  ++  
Sbjct: 1443 EKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSE 1502

Query: 300  WEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKD 359
             E E+S ++K L  +  KL      + K+ +I   E+   + +I ++ E ++  + ++K+
Sbjct: 1503 KETEISTIQKQLEAINDKL------QNKIQEIYEKEEQFNIKQISEVQEKVNELK-QFKE 1555

Query: 360  LREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEG 419
             R K K  A Q     S E K      ++ +  ++    I +KE        ++K ++E 
Sbjct: 1556 HR-KAKDSALQ-----SIESKMLELTNRLQESQEEIQIMIKEKE--------EMKRVQEA 1601

Query: 420  L-ITLQELQQATKTVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTA----KIK 474
            L I   +L++ TK +  +          +ESQ       KM  + +   +       K +
Sbjct: 1602 LQIERDQLKENTKEIVAKM---------KESQEKEYQFLKMTAVNETQEKMCEIEHLKEQ 1652

Query: 475  AEIQAIT-EKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELK-EEEKAFVNKEKM 532
             E Q +  E I+   +R  ++L+E     + ++     +  +   LK E ++   N  + 
Sbjct: 1653 FETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRET 1712

Query: 533  LMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQ--R 590
            + ++L K EE+ +    + KE +E + +    +     E    ++ LE  ++ + AQ  +
Sbjct: 1713 ITRDLEKQEELKIVHMHL-KEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLK 1771

Query: 591  QEEDLLNNHIFLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNLENGFYIND 650
             +E+L   H+ L            ++ ++ + +LR   S+K        K+LEN      
Sbjct: 1772 IQEELRIAHMHL------------KEQQETIDKLRGIVSEKTDKLSNMQKDLENS----- 1814

Query: 651  QKADLLLLENKKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQ 710
                     N KL+E I  LK N  +       L    N+  +++   E   K +  +  
Sbjct: 1815 ---------NAKLQEKIQELKANEHQLI----TLKKDVNETQKKVSEMEQLKKQIKDQSL 1861

Query: 711  TTVKILVDN---GEETLQDINNLTDKLRERDEKMQHVSTWLRGSLEGLRLLVEQESPMDL 767
            T  K+ ++N    ++  +++  +   ++ERD  ++ V   L+   + L+  +++    DL
Sbjct: 1862 TLSKLEIENLNLAQKLHENLEEMKSVMKERDN-LRRVEETLKLERDQLKESLQETKARDL 1920

Query: 768  LSKQQLRALLVTSKE-------------EKTCQLSDL 791
              +Q+L+   + SKE             EKT Q+SD+
Sbjct: 1921 EIQQELKTARMLSKEHKETVDKLREKISEKTIQISDI 1957



 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 166/792 (20%), Positives = 333/792 (42%), Gaps = 110/792 (13%)

Query: 78   VKKLEEMRKATIDLLEIESMELNKLYYLLETL--PNSIKREL---EECVRDARRLNLF-- 130
            +KKL+E     ID  ++E+++++ L Y LE++  P  +K+ L   E    DA+R + F  
Sbjct: 591  IKKLQEY----IDSQKLENIKMD-LSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLR 645

Query: 131  --------EINTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFVLSLN 182
                    ++  +     + EN+I+L + ++    K    L ++ +    +  +    ++
Sbjct: 646  SENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLID 705

Query: 183  QTMEKKATTTVYINETYTKINLK-----REDIALQKKCIQEAEELMEKERAEYLIRK-QE 236
              + K     + +    T +  +      E+ AL+++ I  +E        E L ++ Q+
Sbjct: 706  GKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQD 765

Query: 237  LTAQINEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIA----- 291
             + +++   + ++    E   K+  +  L  ++ K K+ +  + +     + E       
Sbjct: 766  KSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTL 825

Query: 292  ----------------RLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDE 335
                            R+++ I    +E  +    L  L+ +L + T   ++       E
Sbjct: 826  HMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQE----KTRE 881

Query: 336  KNEFLNKIKQLVE-------TLHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKI 388
              E LN+++QL E       TL     E   + EK++    + K  L++E+    Q Q+ 
Sbjct: 882  VQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVK-TLTQEKDDLKQLQES 940

Query: 389  HDENQKQLTFISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKI---LSANL 445
                + QL     K        ++I   E+    L+ L+Q  +T+   + KI   +S NL
Sbjct: 941  LQIERDQL-----KSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNL 995

Query: 446  ERESQRCVIT---QWKMACLRKKH---ARWTAKIKAEIQAITEKIQNAEVRRIELLNETS 499
              E          Q KM  + KK    A+ T  + A+++    +I   + +   L+ E +
Sbjct: 996  HMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVK--DNEIIEQQRKIFSLIQEKN 1053

Query: 500  FRQQEISGFVAQIEKLTTELKEE-EKAFVNKE--KMLMKELSKYEEIFVKETQINKEKEE 556
              QQ +   +A+ E+L T+LKE  E    N+E  ++L  EL K +EI  +E     +KE 
Sbjct: 1054 ELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEG 1113

Query: 557  ELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMED 616
            EL     +L   E++ KEK ++L+E    +   ++E   +   I     +    + N E 
Sbjct: 1114 ELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEI-ENLKNELKNKEL 1172

Query: 617  VKQELQQLRDQESKKNKDHFETLKNLENGFYINDQKADLLLLENKKLKEYILYLK-NNIE 675
              + ++  R + ++K  +++E +K++     +  +       E   L+ YI  ++   ++
Sbjct: 1173 TLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQ 1232

Query: 676  KYREGQEALMH------TSNDLSRQLIAQEAQY---KDL---WAEFQTTVKIL------- 716
               E + A +H      T ++L R +  + AQ    +DL     + Q  + +L       
Sbjct: 1233 TKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELL 1292

Query: 717  -----VDNGEETLQDINNLTDKLRERDEKMQHVSTWLRGSLEGLRLLVE-QESPMDLLSK 770
                 V   +ET+ ++  LT++   +D      +T  R  +E LRL  + QES  ++ S 
Sbjct: 1293 PNVKEVSETQETMNELELLTEQSTTKDS-----TTLARIEMERLRLNEKFQESQEEIKSL 1347

Query: 771  QQLRALLVTSKE 782
             + R  L T KE
Sbjct: 1348 TKERDNLKTIKE 1359



 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 168/810 (20%), Positives = 355/810 (43%), Gaps = 118/810 (14%)

Query: 47   EQLFVVEQSLQSDYF---KCNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIE-SMELNKL 102
            E L +    L+SD       N + +  L++   ++K+ +E    TI+ L+ + S E+++ 
Sbjct: 939  ESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQE----TINTLKSKISEEVSRN 994

Query: 103  YYLLETLPNSIKRELEECVRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEA 162
             ++ E    +     ++ V   ++ +L   NT  +     +NEI   ++KI  L +    
Sbjct: 995  LHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNE 1054

Query: 163  LGEKQEELARKHARFVLSLNQTMEKKATTTVYINETYTKINLKREDIA------------ 210
            L +  E +  +  +    L + +E        +     ++  ++E +A            
Sbjct: 1055 LQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGE 1114

Query: 211  LQKKC--IQEAEELMEKERAEYLIRKQ-----------ELTAQINEFENTREVKRMETYQ 257
            L + C  + E EE + KE+++ L  KQ           E+  +INE EN +     E   
Sbjct: 1115 LSRTCDRLAEVEEKL-KEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKN----ELKN 1169

Query: 258  KKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAK 317
            K+  L+ ++T+  ++ + +  +   +     E   L E  + +E E   L+  +  +EA 
Sbjct: 1170 KELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEA- 1228

Query: 318  LCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLSE 377
                T  + K+  I   E  E ++++++ V    A  +  +DL EK  T  ++   VL E
Sbjct: 1229 TGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDL-EKSHTKLQEEIPVLHE 1287

Query: 378  EEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQ 437
            E++     +++ +  +         E   ++    +  +E   + L E  Q +    Q++
Sbjct: 1288 EQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQES----QEE 1343

Query: 438  IKILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNE 497
            IK L+   ER++ + +        L  KH     ++K  I+    KIQ ++ ++ + LN 
Sbjct: 1344 IKSLTK--ERDNLKTI-----KEALEVKH----DQLKEHIRETLAKIQESQSKQEQSLNM 1392

Query: 498  TSFRQQEISGFVAQIEK-----------------LTTELKE--EEKAFVNKEKMLMKELS 538
               +  E +  V+++E+                 L+  L+E  +E   V KEK    +L 
Sbjct: 1393 KE-KDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEK---DDLQ 1448

Query: 539  KYEEIFVKETQINKEKEEELV----EYLPQLQVAEQEYKEKRRKLEEL--------SNII 586
            + +E+   E+   KE  +E+V    E   +L+VA    KE+   + EL        + I 
Sbjct: 1449 RLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEIS 1508

Query: 587  TAQRQEE---DLLNNHI-FLFTRDFSRYISNMEDVKQELQQLRD-QESKKNKDHFETLKN 641
            T Q+Q E   D L N I  ++ ++    I  + +V++++ +L+  +E +K KD    L++
Sbjct: 1509 TIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKD--SALQS 1566

Query: 642  LENGFYINDQKADLLLLENK--KLKEYILYLKNNIEKYREGQEALMHTSNDL---SRQLI 696
            +E         + +L L N+  + +E I  +    E+ +  QEAL    + L   +++++
Sbjct: 1567 IE---------SKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIV 1617

Query: 697  AQEAQYKDLWAEFQTTVKILVDNGEETLQDINNLTDKLRERDEKMQHVSTWLRGSLEGLR 756
            A+  + ++   E+Q      V+  +E + +I +L ++   +   ++++ T    ++   +
Sbjct: 1618 AKMKESQE--KEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIET---ENIRLTQ 1672

Query: 757  LLVEQESPMDLLSKQQ--LRALLVTSKEEK 784
            +L E    M  ++K++  LR++  T K E+
Sbjct: 1673 ILHENLEEMRSVTKERDDLRSVEETLKVER 1702



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 140/718 (19%), Positives = 302/718 (42%), Gaps = 129/718 (17%)

Query: 62   KCNEEAKIFLK-DIAVAVKKLEEMRKA---------TIDLLEIESMEL-NKLYYLLETLP 110
            K NE   I LK D+    KK+ EM +          T+  LEIE++ L  KL+  LE + 
Sbjct: 1826 KANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMK 1885

Query: 111  NSIKR----------------ELEECVRDARRLNLF---EINTIKMRITRTENEIELLKK 151
            + +K                 +L+E +++ +  +L    E+ T +M     +  ++ L++
Sbjct: 1886 SVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLRE 1945

Query: 152  KIT-----------DLTKYNEALGEKQEELARKHARFV-------LSLNQTMEKKATTTV 193
            KI+           DL K  + L +K +EL +K  + +       +S  +  E +     
Sbjct: 1946 KISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQ 2005

Query: 194  YINETYTKINLKREDIALQKKCIQEAEEL----------------MEKERAEYLIRKQEL 237
            +  +  +  +++ ++  L KK  +  EE+                ++ ER +++   +E+
Sbjct: 2006 FEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREM 2065

Query: 238  TAQINEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESI 297
             A+  +    +  KR+ +  ++   + L+ K S+IKE +    + + DH   + RL   +
Sbjct: 2066 IARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLK-RYSEMDDHYECLNRLSLDL 2124

Query: 298  RYWEQEVSELKKDLAI-LEAKLC---FFTDNKEKLDDISNDEKNEF---LNKIKQLV--- 347
               E+E+ E +K+L++ ++A L      T + EKL   +     EF   + K+K ++   
Sbjct: 2125 ---EKEI-EFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYV 2180

Query: 348  --------ETLHAARMEYKDLREKMKTL------ARQYKIVLSEEEKAFLQKQKIHDENQ 393
                    E+++   M++ D  EK K L       +Q   V S E +     Q +    +
Sbjct: 2181 TKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIE 2240

Query: 394  KQLTFISQKEY---------FLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSAN 444
            + L   S+ E+          LS ++   + +EE L T  ++++    + ++  +I   N
Sbjct: 2241 EILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVN 2300

Query: 445  LERESQRCVITQWKMACLRKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQE 504
                + R +    +     ++ A  + + + +++++ EK +          N  + +   
Sbjct: 2301 -NFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKL------FKNYQTLKTSL 2353

Query: 505  ISGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQ 564
             SG  AQ+   TT+  +         ++  +++ + E    +  +    KE ++++   +
Sbjct: 2354 ASG--AQVNP-TTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKE 2410

Query: 565  LQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQQL 624
            L+V      + + K+ E +  +   ++   +L + + L  +    Y   +ED+K +L ++
Sbjct: 2411 LEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKP---YKEEIEDLKMKLVKI 2467

Query: 625  RDQESKKNKDHFETLKNLENGFYINDQKADLLLLENKKLKEYILYLKNNIEKYREGQE 682
             D E  KN   FE          I+  KA +     +  KE I  L+ N+ + ++ Q+
Sbjct: 2468 -DLEKMKNAKEFEK--------EISATKATV-----EYQKEVIRLLRENLRRSQQAQD 2511


>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 899

 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 145/686 (21%), Positives = 301/686 (43%), Gaps = 74/686 (10%)

Query: 98  ELNKLYYLLETLPNSIKRELEECV--RDARRLNLFEINTIKMRITRTENEIELLKKKITD 155
           EL +    + T      R +EE    RDA  L L+  NTI     + +N     K  + +
Sbjct: 180 ELQRALSAVSTRHKKADRYIEELTKERDALSLELYR-NTITNEELKKKNAELQEKLPLAE 238

Query: 156 LTKYNEALGEKQEELARKHARFVLSLNQTMEKKATTTVYINETYTKINLKREDIALQKKC 215
             K    L  K+ +   + A+F+L   QT           N    ++  + E++  Q+K 
Sbjct: 239 SEKSEIQLNVKELKRKLERAKFLLPQVQT-----------NTLQEEMWRQEEELREQEKK 287

Query: 216 IQEAEELMEKERAEYLIRKQELTAQINEFENTREVKRMETYQKK-----------KELDK 264
           I++ EE M ++  E  +R+QE   +  E +  R+ KR+   +K+           KEL +
Sbjct: 288 IRKQEEKMWRQ--EERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELRE 345

Query: 265 LQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFFTDN 324
            + +M + +E +      + +   ++ R  E  R WEQE     K +   E K+    D 
Sbjct: 346 QEEQMQEQEEKMWEQEEKMREQEEKMWRQEE--RLWEQE-----KQMREQEQKM---RDQ 395

Query: 325 KEKL--DDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLSEEEKAF 382
           +E++   D    EK E + + +++ E +   R E K   ++ KT  ++ K  + EEE+  
Sbjct: 396 EERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEK--MQEEERIR 453

Query: 383 LQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILS 442
            +++K+ +E +   T   Q+E    Q        EE +   +E +   + + +Q+ K+  
Sbjct: 454 EREKKMREEEE---TMREQEEKMQKQ--------EENMWEQEEKEWQQQRLPEQKEKLWE 502

Query: 443 ANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQ 502
               +E +  +  Q +   +R +   W  + K   Q   EK++  E +  E   +   ++
Sbjct: 503 QEKMQEQEEKIWEQEEK--IRDQEEMWGQEKKMWRQ---EKMREQEDQMWEQEEKMRDQE 557

Query: 503 QEISGFVAQIEKLTTELKEEEKAFVNKEKMLMKE-LSKYEEIFVKETQINKEKEEELVEY 561
           Q++     ++EK T E  +E+K +  +EKM  +E + + E+   +E ++ +E+EE++ E 
Sbjct: 558 QKMWDQEERMEKKTQE--QEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQ 615

Query: 562 LPQLQVAEQEYKEKRRKLEELSNIITAQR-----QEEDLLNNHIFLFTRDF---SRYISN 613
             ++Q  E++  E+  K++E    +  Q      QEE +         ++       +  
Sbjct: 616 EEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQE 675

Query: 614 MEDVKQELQQLRDQESKKNKDHFETLKNLENGFYINDQKADLLLLENKKLKEYILYLKNN 673
            E ++++ +++ +QE  + K   +  K  +       ++ + +    KK++E    ++  
Sbjct: 676 QEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQE---KMREEESMREREKKMREEEEMMREQ 732

Query: 674 IEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEF---QTTVKILVDNGEETLQDINNL 730
            EK +E +E +     ++  Q      Q + +W +    +   K+      +  + I   
Sbjct: 733 EEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQ 792

Query: 731 TDKLRERDEKMQHVSTWLRGSLEGLR 756
            +K+R+++EKM+     +RG  E +R
Sbjct: 793 EEKMRDQEEKMRGQEEKMRGQEEKMR 818



 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 128/697 (18%), Positives = 299/697 (42%), Gaps = 58/697 (8%)

Query: 88  TIDLLEIESMELNKLYYLLETLPNSIKRELEECVRDARRLNLF----EINTIKMRITRTE 143
           T + L+ ++ EL +   L E+  + I+  ++E  R   R        + NT++  + R E
Sbjct: 219 TNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQE 278

Query: 144 NEIELLKKKITDLTKYNEALGEKQEELARKHARFVLSLNQTMEKKATTTVYINETYTKIN 203
            E+   +KKI    K  E +  ++E L  +  +    + +  EK       + E   ++ 
Sbjct: 279 EELREQEKKIR---KQEEKMWRQEERLREQEGK----MREQEEKMWRQEKRLREQEKELR 331

Query: 204 LKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVKRMETYQKKKELD 263
            + +++  QK+  ++ E++ E+E   +   +QE   +  E +  R+ +R+  ++++K++ 
Sbjct: 332 EQEKELREQKELREQEEQMQEQEEKMW---EQEEKMREQEEKMWRQEERL--WEQEKQMR 386

Query: 264 KLQTKMSKIKETVTVSAAVLSDHNL----------EIARLHESIRYWEQEVSELKKDLAI 313
           + + KM   +E +      L +             ++ ++ E  +  EQE     ++  +
Sbjct: 387 EQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKM 446

Query: 314 LEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKI 373
            E +     + K + ++ +  E+ E + K ++ +        + + L E+ + L  Q K+
Sbjct: 447 QEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKM 506

Query: 374 VLSEEEKAFLQKQKIHDENQ---------KQLTFISQKEYFLSQKRVDIKNMEEGLITLQ 424
              +EEK + Q++KI D+ +         +Q     Q++    Q+   +++ E+ +   +
Sbjct: 507 Q-EQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEE-KMRDQEQKMWDQE 564

Query: 425 E-----LQQATKTVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQA 479
           E      Q+  K  + Q+ K+      RE +R    + KM    ++      + + ++Q 
Sbjct: 565 ERMEKKTQEQEKKTWDQEEKM------REEERMREREKKM----REEEEMMREQEEKMQE 614

Query: 480 ITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSK 539
             EK+Q  E +  E   E   ++QE   +  + +    E K  E+  + ++K  + E  K
Sbjct: 615 QEEKMQEQEEKMWE--QEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEK 672

Query: 540 YEEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNH 599
            +E    + Q  K  E+E +E   Q Q  +   +EK R+ E +       R+EE+++   
Sbjct: 673 MQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQ 732

Query: 600 IFLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNLENGFYINDQKADLLLLE 659
                    +     E++ ++ +++ +QE K  +      +  +   +   Q+ + +  +
Sbjct: 733 EEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQ 792

Query: 660 NKKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTTVKILVDN 719
            +K+++    ++   EK R  +E +      +  Q      Q + +W + +     +   
Sbjct: 793 EEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEK----MWGQ 848

Query: 720 GEETLQDINNLTDKLRERDEKMQHVSTWLRGSLEGLR 756
            E+  + +    +K+RE++EKM+     +R   E +R
Sbjct: 849 EEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMR 885



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 95/481 (19%), Positives = 203/481 (42%), Gaps = 104/481 (21%)

Query: 306 ELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAAR-----MEYKDL 360
           ELKK  A L+ KL            ++  EK+E    +K+L   L  A+     ++   L
Sbjct: 222 ELKKKNAELQEKL-----------PLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTL 270

Query: 361 REKM----KTLARQYKIVLSEEEKAFLQKQKIHDENQK---QLTFISQKEYFLSQKRVDI 413
           +E+M    + L  Q K +  +EEK + Q++++ ++  K   Q   + ++E  L ++  ++
Sbjct: 271 QEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKEL 330

Query: 414 KNMEEGLITLQELQQATKTVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKI 473
           +  E+ L   +EL++  + + +Q+ K+     +   Q      W     R++   W  + 
Sbjct: 331 REQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQE--EKMW-----RQEERLWEQEK 383

Query: 474 KAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKML 533
           +   Q   +K+++ E R  E   +   R++E              ++E+EK +   EKM 
Sbjct: 384 QMREQE--QKMRDQEERMWE--QDERLREKE------------ERMREQEKMWEQVEKMR 427

Query: 534 MKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEE 593
            ++  + +E   ++ +   ++EE + E   +++  E+  +E+  K+         Q+QEE
Sbjct: 428 EEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKM---------QKQEE 478

Query: 594 DLLNNHIFLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNLENGFYINDQK- 652
           ++                   E  ++E QQ R  E K+     E ++  E   +  ++K 
Sbjct: 479 NM------------------WEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKI 520

Query: 653 --------ADLLLLENKKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKD 704
                    +  +   +K++E    +    EK R+ ++ +      + ++   QE   K 
Sbjct: 521 RDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQE---KK 577

Query: 705 LWAEFQTTVKILVDNGEETLQDINNLTDKLRERDEKMQHVSTWLRGSLEGLRLLVEQESP 764
            W +            EE +++     +++RER++KM+     +R   E ++   EQE  
Sbjct: 578 TWDQ------------EEKMRE----EERMREREKKMREEEEMMREQEEKMQ---EQEEK 618

Query: 765 M 765
           M
Sbjct: 619 M 619


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score = 95.9 bits (237), Expect = 1e-19
 Identities = 136/684 (19%), Positives = 292/684 (42%), Gaps = 71/684 (10%)

Query: 131  EINTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFVLSLNQTMEKKAT 190
            ++  ++ R+T TE E   +  ++ DL +    L + QEE ++   +     ++ ME    
Sbjct: 1265 QVQKLEERLTDTEAEKSQVHTELQDLQRQ---LSQNQEEKSKWEGKQNSLESELME---- 1317

Query: 191  TTVYINETYTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQINE------- 243
                ++ET   +  +     LQ+   Q   EL++  +     + + L A + E       
Sbjct: 1318 ----LHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASA 1373

Query: 244  ---FENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYW 300
                E      R     K +E++  + +   ++E   +  A        +A L +++   
Sbjct: 1374 AGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAER 1433

Query: 301  EQEVSELKKDLAILEAKLCFFTDNKEKLDDISND--EKNEFLNKIKQLVETLHAARMEYK 358
            E+EV  L+  +  LE +       K  L+ +S D  ++N+ ++  ++ ++ L   R   +
Sbjct: 1434 EEEVETLRGQIQELEKQREM---QKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLE 1490

Query: 359  DLREKMKTLARQYKIVLSEEEKAFLQKQKIHDEN--QKQLTFISQKEYFLSQKRVDIKNM 416
             L   M    R+ K+ +  E+   L+K +    N  + QL  + +K+  +  +R  ++++
Sbjct: 1491 HL--PMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDL 1548

Query: 417  EEGLITLQ----ELQQATKTVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAK 472
            ++ L+TL+    EL++    +  QQ  I     +RE+QR  +T   +    +        
Sbjct: 1549 KKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQ------ 1602

Query: 473  IKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKM 532
               E+QA + +I + E     L  E   R QE+     QIE+L  + +   +    +++ 
Sbjct: 1603 ---ELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQE 1659

Query: 533  LMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQE 592
            LM +  + + +  + T+  K  EE+L +    L+   +E   +R+ ++E +       + 
Sbjct: 1660 LMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKA 1719

Query: 593  EDLLNNHIFLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNLENGFYINDQK 652
            +     H+ L  RD  + +   ++   ELQ+L+DQ           L+    G +    +
Sbjct: 1720 QRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQ-----------LEQQLQGLHRKVGE 1768

Query: 653  ADLLLLENKKLKEYILYLKNNIEKYREG---QEALMHTSNDLSRQLIAQEAQYKDLWAEF 709
              LLL +    ++ I+ L+  +++ RE    +E  + +  D +++ +AQ  Q  +   + 
Sbjct: 1769 TSLLLSQR---EQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQE 1825

Query: 710  QTTVKILVDNGEETLQDINNLTDK----LRERDEKMQHVSTWLRG-----SLEGLRLLVE 760
            Q   +   +  +E    +    ++    L+ER  ++Q      R      ++EG R+   
Sbjct: 1826 QQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQAL 1885

Query: 761  QESPMDLL--SKQQLRALLVTSKE 782
            +E   DL   S++Q +ALL   ++
Sbjct: 1886 EEVLGDLRAESREQEKALLALQQQ 1909



 Score = 80.1 bits (196), Expect = 8e-15
 Identities = 159/803 (19%), Positives = 329/803 (40%), Gaps = 109/803 (13%)

Query: 44   EALEQLFVVEQSLQSDYFKCNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKLY 103
            + L++L     +L         E     K+  +  K  EE+R+  +++LE E+  L ++ 
Sbjct: 435  QRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQ-LEVLEQEAWRLRRVN 493

Query: 104  YLLETLPNSIKRELEE-------CVRDARRL-------------NLFEINTIKMRITRTE 143
              L+   +S + + EE        VR+  RL             +L E+ T++  +  + 
Sbjct: 494  VELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSH 553

Query: 144  NEIELLKKKITDLTKYNEALGEKQEELARKHAR-------------FVLSLNQTMEKKAT 190
             E ELL+++ T++T    AL   ++ +A   +                + L+   E  A 
Sbjct: 554  LEGELLRQEQTEVTA---ALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALAL 610

Query: 191  TTVYINETYTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQ-------ELTAQINE 243
              V +N+   ++  + + +  + +  ++A   ++ + AE   R++        L AQ+ +
Sbjct: 611  DKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQK 670

Query: 244  FENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWEQE 303
             E      + +    ++E +++Q K+S+ +     +   L   + E  R  E +    QE
Sbjct: 671  AEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQE 730

Query: 304  VSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDLREK 363
               L ++ A LE +L     +++ L      E+ + L+  K+L+E   ++  E +     
Sbjct: 731  KEALVREKAALEVRLQAVERDRQDL-----AEQLQGLSSAKELLE---SSLFEAQQQNSV 782

Query: 364  MKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLITL 423
            ++    Q ++ +    +A   K+ I  E +     +  +     Q+R      +     L
Sbjct: 783  IEVTKGQLEVQIQTVTQA---KEVIQGEVRCLKLELDTERSQAEQER------DAAARQL 833

Query: 424  QELQQATKTVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAITEK 483
             + +Q  KT  +QQ     A  E+E  +          LR+K   W  +     Q + + 
Sbjct: 834  AQAEQEGKTALEQQ----KAAHEKEVNQ----------LREK---WEKERSWHQQELAKA 876

Query: 484  IQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELK--------EEEKAFVNKEKMLM- 534
            +++ E  ++EL      +Q E+    AQ E+  T+ +        E EK  V+  + L+ 
Sbjct: 877  LESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQ 936

Query: 535  --KEL---SKYEEIFVKETQINKEKEEELVEYL-PQLQVAEQEYKEKRRKLEELSNIITA 588
              KEL   S+  E   ++ ++ K KE+E    L  QLQ A++E KE  R  +   ++   
Sbjct: 937  TQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAAR--QHRDDLAAL 994

Query: 589  QRQEEDLLNNHIFL--FTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNLENGF 646
            Q +   LL + + L     D    +   +D ++ ++Q   ++ ++ +++    K LE   
Sbjct: 995  QEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELER-- 1052

Query: 647  YINDQKADLLL-LENKKLKEYILYLKNNIEK-----YREGQEALMHTSNDLSRQLIAQEA 700
                +KA L L L  K+ +  +L   ++I +      R+  +       +LS Q+     
Sbjct: 1053 ----EKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQ 1108

Query: 701  QYKDLWAEFQTTVKILVDNGEETLQDINNLTDKLRERDEKMQHVSTWLRGSLEGLRLLVE 760
            + K+  A+F      L++  E +      L   L  ++ K   +   LR +   L  L  
Sbjct: 1109 EVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAA 1168

Query: 761  QESPMDLLSKQQLRALLVTSKEE 783
            ++ P +    Q   A L ++ ++
Sbjct: 1169 EQQPGNQAQAQAQLASLYSALQQ 1191



 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 172/850 (20%), Positives = 358/850 (42%), Gaps = 171/850 (20%)

Query: 82   EEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEECVRDARR-LNLFEINTIKMRIT 140
            +E+ KA ++ LE E MEL       +T   +I+ + EE    A   L   ++ T K R++
Sbjct: 871  QELAKA-LESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVS 929

Query: 141  RTENEIELLKKKITDLTKYNEALGE--KQEELARKHARFVLSLNQTMEKKATTTVYINET 198
              E  ++  +K++ D ++  E L +  K ++L  +    +L   QT  ++A       E 
Sbjct: 930  LLETLLQT-QKELADASQQLERLRQDMKVQKLKEQETTGIL---QTQLQEAQ-----REL 980

Query: 199  YTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVKRMETYQK 258
                   R+D+A     +QE    + +++ +   + ++L +Q+   ++++ +   E  +K
Sbjct: 981  KEAARQHRDDLA----ALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEK 1036

Query: 259  KKEL---DKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILE 315
             +E    +++Q ++ + K ++T+S  +  +  L + +  +SIR  +QE+S L++D+   +
Sbjct: 1037 LRETQEYNRIQKELEREKASLTLSL-MEKEQRLLVLQEADSIR--QQELSALRQDMQEAQ 1093

Query: 316  AKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKM---KTLARQYK 372
             +    +   E L     +++ +FL +  QL+E L A+ +  + LR  +   +  A Q +
Sbjct: 1094 GEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQ 1153

Query: 373  IVLSEEE---KAFLQKQKIHDENQKQLTFIS------QKEYFLSQKRVDIKNMEEGLITL 423
            + L   E   +A   +Q+  ++ Q Q    S      Q    + + R ++    +   ++
Sbjct: 1154 LRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSV 1213

Query: 424  QELQ--------------------------------------QATKTVYQQQIKILSANL 445
              L+                                      Q T+ V + Q++ L   L
Sbjct: 1214 WGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERL 1273

Query: 446  -ERESQRCVI------TQWKMACLRKKHARWTAK---IKAEIQAITE-------KIQNAE 488
             + E+++  +       Q +++  +++ ++W  K   +++E+  + E       +++ AE
Sbjct: 1274 TDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAE 1333

Query: 489  VRRIELLNETSFRQQEISGFVAQIEKL--------------------------TTELKEE 522
            ++R+E   E    Q       AQ+E L                            +LK E
Sbjct: 1334 LQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNE 1393

Query: 523  EKAFVNKEKMLMKELSKYEEIFVKE-----------TQINKEKEEELVEYLPQLQVAEQE 571
            E   V  E+   + L +  E+ V +           TQ   E+EEE+     Q+Q  E++
Sbjct: 1394 E---VESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQ 1450

Query: 572  YKEKRRKLEELSNIITAQRQEEDL-------------LNNHIFLFTRDFSRYISNMEDVK 618
             + ++  LE LS  +  + QE DL             +  H+ +  ++  + ++   +  
Sbjct: 1451 REMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQI 1510

Query: 619  QELQQLRDQESKKNKDHFETLKNLENGFYINDQKAD---------------LLLLENKKL 663
            +EL+  +D+E+++N    + L+  +    I  Q+                 L L EN   
Sbjct: 1511 RELE--KDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHK 1568

Query: 664  KEYILYLKNNIEKYREGQE-ALMHTSNDL---SRQLIAQEAQYKDLWAEFQTTVKILVDN 719
             E    L   +E  RE Q  AL H + DL   S++L AQ +Q  DL  E  +TV  L   
Sbjct: 1569 MECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDL--ESHSTV--LARE 1624

Query: 720  GEETLQDINNLTDKLRERDEKMQHVSTWLRGSLEGLRLLVEQESPMDLLSKQQLRALLVT 779
             +E  Q++ +  +++ E   + +H++  L    + L L   Q+  + +L  Q+ R   + 
Sbjct: 1625 LQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELML---QKERIQVLEDQRTRQTKIL 1681

Query: 780  SKEEKTCQLS 789
             ++ +  +LS
Sbjct: 1682 EEDLEQIKLS 1691



 Score = 73.6 bits (179), Expect = 7e-13
 Identities = 151/724 (20%), Positives = 293/724 (40%), Gaps = 118/724 (16%)

Query: 47   EQLFVVEQSLQSDYFKCNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLL 106
            E L ++ Q+L        EE    L+     ++K  EM+KA ++LL   S++L K    +
Sbjct: 1421 ENLALLTQTLAE-----REEEVETLRGQIQELEKQREMQKAALELL---SLDLKKRNQEV 1472

Query: 107  ETLPNSIKRELEECVRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEALGEK 166
            +     I+ ELE+C      L         M +   E ++ + +++I +L K  E     
Sbjct: 1473 DLQQEQIQ-ELEKCRSVLEHL--------PMAVQEREQKLTVQREQIRELEKDRET---- 1519

Query: 167  QEELARKHARFVLSLNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKE 226
                     R VL  +Q +E +    +  ++     +LK++ + L+   ++  E   + E
Sbjct: 1520 --------QRNVLE-HQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKME 1570

Query: 227  RAEYLIRKQELTAQINEFENTREVKR-------METYQKKKELDKLQTKMSKIKETVTVS 279
              + LI+         E E  RE +R       ++  ++ +EL    +++  ++   TV 
Sbjct: 1571 CQQKLIK---------ELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVL 1621

Query: 280  AAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEF 339
            A  L + + E+    E I   +++   L +DL   + +L    +  + L+D       + 
Sbjct: 1622 ARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLED-------QR 1674

Query: 340  LNKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFI 399
              + K L E L   ++  ++ R +  T  RQ     +EE K   + Q+   E+ K +   
Sbjct: 1675 TRQTKILEEDLEQIKLSLRE-RGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLI--- 1730

Query: 400  SQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQ---QQIKILSANLERESQRCVITQ 456
                  L  K  +++  +E +  LQEL+   +   Q   +++   S  L +  Q  V+ Q
Sbjct: 1731 ------LRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQ 1784

Query: 457  WKMACLRKKHARWTAKIKAE-IQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKL 515
             ++     + AR   ++K + +Q+  ++ Q A  +R + L      QQ+  G   ++++ 
Sbjct: 1785 QQL-----QEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEK 1839

Query: 516  TTELKEEEKAFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQ----- 570
               L+      + +  M +KE  ++ E+   + Q  + +EE  VE   ++Q  E+     
Sbjct: 1840 ADALQ----GALEQAHMTLKE--RHGELQDHKEQARRLEEELAVEGR-RVQALEEVLGDL 1892

Query: 571  --EYKEKRRKLEELSNIITAQRQEEDL---------LNNHIFLFTRDFSRYISNMEDVKQ 619
              E +E+ + L  L      Q QE ++         L     L  RD       +E ++ 
Sbjct: 1893 RAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERD-----QELEALRA 1947

Query: 620  ELQQLRDQESKKNKDHFETLKNLENGFYINDQKADLLLLENKKLKEYILYLKNNIEKYRE 679
            E Q  R QE    +   E L+      +   Q  +  LLE  +L      L+ +    + 
Sbjct: 1948 ESQSSRHQEEAA-RARAEALQEALGKAHAALQGKEQHLLEQAELSRS---LEASTATLQA 2003

Query: 680  GQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTTVKILVDNGEETLQDINNLTDKLRERDE 739
              +A    S  L   L  QE + +D    +Q              +D+  L   L +RDE
Sbjct: 2004 SLDACQAHSRQLEEALRIQEGEIQDQDLRYQ--------------EDVQQLQQALAQRDE 2049

Query: 740  KMQH 743
            +++H
Sbjct: 2050 ELRH 2053



 Score = 56.6 bits (135), Expect = 9e-08
 Identities = 129/738 (17%), Positives = 309/738 (41%), Gaps = 99/738 (13%)

Query: 78   VKKLEEMRKATIDLLEIESMELNKLYYLLETLPNSI---KRELE--ECVRDARRLNLFEI 132
            +++LE+ R+   ++LE + +EL K   ++E+    +   K++L   EC+      N  ++
Sbjct: 1510 IRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKM 1569

Query: 133  NTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFVLSLNQTMEKKATTT 192
               +  I   E + E  +  +T LT     L E+ +EL  + ++        +E  +T  
Sbjct: 1570 ECQQKLIKELEGQRETQRVALTHLTL---DLEERSQELQAQSSQI-----HDLESHSTVL 1621

Query: 193  VY-INETYTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVK 251
               + E   ++  +RE I   ++  +   + +E+   E +++K+ +  Q+ E + TR+ K
Sbjct: 1622 ARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERI--QVLEDQRTRQTK 1679

Query: 252  RMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDH-------------NLEIARL----- 293
             +E     ++L++++  + +    +T    ++ +              +LE  +L     
Sbjct: 1680 ILE-----EDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDK 1734

Query: 294  HESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAA 353
             + +   ++ + EL++    LE +L        +   + +  + E +   +QL E     
Sbjct: 1735 EKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQG 1794

Query: 354  RMEYKDLREKMKTLAR-------QYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFL 406
             ++ + L+ ++    R       + + +  E+++A  Q++++ ++       + Q    L
Sbjct: 1795 ELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTL 1854

Query: 407  SQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSANLERESQRCVITQWKMACLRKKH 466
             ++  ++++ +E    L+E + A +    Q ++ +  +L  ES+     +  +  L+++ 
Sbjct: 1855 KERHGELQDHKEQARRLEE-ELAVEGRRVQALEEVLGDLRAESRE---QEKALLALQQQC 1910

Query: 467  ARWTAKIKAEIQAITE---------KIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTT 517
            A    + + E +A+ +         K ++ E+  +   +++S  Q+E +   A+ E L  
Sbjct: 1911 AEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAAR--ARAEALQE 1968

Query: 518  ELKEEEKAFVNKEKMLMK--ELSKY-----------------------EEIFVKETQINK 552
             L +   A   KE+ L++  ELS+                        E + ++E +I  
Sbjct: 1969 ALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQD 2028

Query: 553  E--KEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRY 610
            +  + +E V+ L Q      E    +++ E+L     AQR +E+++     L        
Sbjct: 2029 QDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEE 2088

Query: 611  ISNMEDVKQEL--------QQLRDQESKKNKDHFETLKNLENGFYINDQKADLLLLENKK 662
            I  +    +EL        Q++ +    + +++ E L +      + +Q   L  LE  +
Sbjct: 2089 IRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLE-PR 2147

Query: 663  LKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLW--AEFQTTVKILVDNG 720
            L+  +  L+  + +    +      + DL+  L   +A    L   A F     +  D+ 
Sbjct: 2148 LQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSE 2207

Query: 721  EETLQDINNLTDKLRERD 738
            ++ LQD   LT +  E++
Sbjct: 2208 QQRLQDELELTRRALEKE 2225



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 98/540 (18%), Positives = 218/540 (40%), Gaps = 72/540 (13%)

Query: 254 ETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARL----HESIRYWEQEVSELKK 309
           +T + +KE  +   ++ ++K    +  A L D   E++ L     +    +E+ +  L++
Sbjct: 252 KTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRE 311

Query: 310 DLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLAR 369
            + ILE       +++  L   + +EK      IK + +           + E+   +A+
Sbjct: 312 TVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQV----------MVEEGDNIAQ 361

Query: 370 QYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLITLQE---L 426
                 S E  + +  Q  + +  K LT +      L+++R  ++++ + L   QE   L
Sbjct: 362 GSGHENSLELDSSIFSQFDYQDADKALTLVRS---VLTRRRQAVQDLRQQLAGCQEAVNL 418

Query: 427 QQATKTVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAITEKIQN 486
            Q     ++++ K L   L+           K+   R   A  T  ++ E+ +++++ + 
Sbjct: 419 LQQQHDQWEEEGKALRQRLQ-----------KLTGERDTLAGQTVDLQGEVDSLSKEREL 467

Query: 487 AEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSKYEEIFVK 546
            +  R EL  +    +QE      ++ ++  EL+ +  +   +++   +EL     + V+
Sbjct: 468 LQKAREELRQQLEVLEQE----AWRLRRVNVELQLQGDSAQGQKEEQQEEL----HLAVR 519

Query: 547 ETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHI--FLFT 604
           E        E L E L  L+          ++ E LS +IT +   E L ++H+   L  
Sbjct: 520 E-------RERLQEMLMGLEA---------KQSESLSELITLR---EALESSHLEGELLR 560

Query: 605 RDFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNLENGFYINDQKADLLLLENKKLK 664
           ++ +   + +   +Q + +L   E+    +    + +L           + L L+   L 
Sbjct: 561 QEQTEVTAALARAEQSIAELSSSENTLKTE----VADLRAAAVKLSALNEALALDKVGLN 616

Query: 665 EYILYLKNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTTVKILVDNGEET- 723
           + +L L+   +      EA     N L   L   E + + LW E  T ++  +   EE  
Sbjct: 617 QQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALW-EKNTHLEAQLQKAEEAG 675

Query: 724 ------LQDINNLTDKLRERDEKMQHVSTWLRGSLEGLRLLVEQESPMDLLSKQQLRALL 777
                 L+DI    ++++++  + +H        LE L    +++  +   + Q+  AL+
Sbjct: 676 AELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALV 735


>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
            sapiens]
          Length = 1843

 Score = 95.9 bits (237), Expect = 1e-19
 Identities = 177/807 (21%), Positives = 336/807 (41%), Gaps = 88/807 (10%)

Query: 40   SVAVEALEQLFVVE-QSLQSDYFKCNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIESME 98
            S  VE LE   V E QSLQ+    C   +K  +K+ A   K +E +R+ +   ++I   E
Sbjct: 504  SKKVEILENEIVQEKQSLQN----CQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQE 559

Query: 99   LNKLYYLLETLPNSIKRELEECVRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTK 158
               L   + +L    +   E  V+D  + N     +IK   ++  ++IE  K++I    +
Sbjct: 560  NEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKL-SKIEFEKRQIKKELE 618

Query: 159  YNEALGEKQEELARKHARFVLSLNQTMEKKATTTVYINETYTKIN-----LKREDIALQK 213
            + +  GE+ EEL  +    +   N+ ++KK T      E    +      L+RE+  L+K
Sbjct: 619  HYKEKGERAEELENE-LHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKK 677

Query: 214  -----KCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVKRMETYQKKKELDKLQTK 268
                 K +    E +EKE ++      EL   +   +    +K  +   + KEL+  + +
Sbjct: 678  TLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLK-CASMKMAQLQLENKELESEKEQ 736

Query: 269  MSKIKETVTVS-------AAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFF 321
            + K  E +  S              ++E  RL +++    +++ +L+ +L  LE +    
Sbjct: 737  LKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTL 796

Query: 322  TDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKIV------- 374
              N E+L  IS+    +   + K L +       + K L ++ K L +Q +I        
Sbjct: 797  QKNLEELK-ISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEEN 855

Query: 375  ------LSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKR-VDIKNMEEGLITLQELQ 427
                  L +E K   ++  I+ E+  +L  + ++   L ++  +DIK     L+TL+E  
Sbjct: 856  NVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKT----LVTLREDL 911

Query: 428  QATKTVYQQQ---IKILSANLER---ESQRCVITQWKMACLRKK--HARWTAKIKAEIQA 479
             + K   QQ    ++ L+  LE+     +R +  +      R K   ++  + +K  ++ 
Sbjct: 912  VSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEI 971

Query: 480  ITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSK 539
              EKI   E R  E  N     +QE+       E L  + +++E+  V     +  E +K
Sbjct: 972  KEEKIAALEARLEESTNYNQQLRQELKTVKKNYEAL--KQRQDEERMVQSSPPISGEDNK 1029

Query: 540  YEEIFVKETQINKEKEEELVEYLPQ---LQVAEQEYKEKRRKLEELSN-----IITAQRQ 591
            +E    + T+   + ++ L+E       LQ  +Q  K + ++LE  +N     I+  QRQ
Sbjct: 1030 WERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQ 1089

Query: 592  EEDLLNNHIFLFTRDFSRYISNM-------EDVKQELQQLRDQESKKNKDHF-----ETL 639
               L   +  L T++    + N          + Q  Q L  Q S +N++       E L
Sbjct: 1090 TVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDL 1149

Query: 640  KNLENGFYINDQKADLLLLENKKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIAQE 699
            K+L +    + +K +LL        E ++     ++   +  E       D   QL+ Q+
Sbjct: 1150 KSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQK 1209

Query: 700  AQYKDLWAEFQT-TVKILVDNGEETLQDINNLTDKLRERDEKMQHVSTWLRGSLEGLRLL 758
             Q +DL    +    K+L++N  +  + +     KL   ++++ H  + L    E L+  
Sbjct: 1210 GQLEDLEKMLKVEQEKMLLEN--KNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQ-- 1265

Query: 759  VEQESPMDLLSKQQLRALLVTSKEEKT 785
                        + L++LL  SK E+T
Sbjct: 1266 ---------TDHKNLKSLLNNSKLEQT 1283



 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 136/640 (21%), Positives = 276/640 (43%), Gaps = 95/640 (14%)

Query: 186 EKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQINEFE 245
           E +   +V + +   KI   R+++  + + + + ++ +E+   E    +QE    +++  
Sbjct: 244 ESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDAR 303

Query: 246 NTREVK-RMETYQKKK-ELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWEQE 303
           + R  +  ++  ++K   +DKL++++S+ KE                 RLH+ I +++  
Sbjct: 304 SARMYRDELDALREKAVRVDKLESEVSRYKE-----------------RLHD-IEFYKAR 345

Query: 304 VSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARME------- 356
           V ELK+D  +L        D  E     S D+ +E   +  QL   LH   ME       
Sbjct: 346 VEELKEDNQVLLETKTMLEDQLEGTRARS-DKLHELEKENLQLKAKLHDMEMERDMDRKK 404

Query: 357 YKDLREKMKTLARQYKIVLSE------EEKAFLQKQKIHDENQKQLTFISQKEYFLSQKR 410
            ++L E+  TL    K  + E      E +   +  ++ +  QK L    +     S + 
Sbjct: 405 IEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGH--EVNELTSSRL 462

Query: 411 VDIKNMEEGLI-TLQELQQATKTVYQQQIKILSANLERESQRCV---------ITQWKMA 460
           + ++   + L  T++EL+    +V     KIL   +E+E+QR           I Q K +
Sbjct: 463 LKLEMENQSLTKTVEELRTTVDSVEGNASKILK--MEKENQRLSKKVEILENEIVQEKQS 520

Query: 461 CLRKKH-ARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTEL 519
               ++ ++   K KA+++   E ++    R+I++L + +    +    + Q  +++ E 
Sbjct: 521 LQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEA 580

Query: 520 KEEEKAFVNK--EKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRR 577
           + ++    NK   + + +  SK  +I  ++ QI KE E                YKEK  
Sbjct: 581 RVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEH---------------YKEKGE 625

Query: 578 KLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFE 637
           + EEL N +    +E +LL   I     +       +E ++QE  +L ++E++K K   +
Sbjct: 626 RAEELENELHHLEKENELLQKKI----TNLKITCEKIEALEQENSEL-ERENRKLKKTLD 680

Query: 638 TLKNLENGFYINDQKADLLLLENKKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIA 697
           + KNL         + + L  EN +L E  L L+ N+E  +     +     + +++L +
Sbjct: 681 SFKNL-------TFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLE-NKELES 732

Query: 698 QEAQYKD----LWAEFQTTVKILV---------DNGEETLQDINNLTDKLRERDEKMQHV 744
           ++ Q K     L A F+ T ++ V            ++TL++ N    +L    + ++  
Sbjct: 733 EKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEME 792

Query: 745 STWLRGSLEGLRLLVEQESPMDLLSKQQLRALLVTSKEEK 784
           +  L+ +LE L++       ++ L K+       TS+ EK
Sbjct: 793 NQTLQKNLEELKI---SSKRLEQLEKENKSLEQETSQLEK 829



 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 165/767 (21%), Positives = 322/767 (41%), Gaps = 120/767 (15%)

Query: 43  VEALEQLFVVEQSLQSDYFKCNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKL 102
           ++AL +  V    L+S+  +  E     L DI     ++EE+++    LLE ++M  ++L
Sbjct: 312 LDALREKAVRVDKLESEVSRYKER----LHDIEFYKARVEELKEDNQVLLETKTMLEDQL 367

Query: 103 YYLLETLPNSIKRELEECVRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEA 162
                           E  R AR   L E+          E E   LK K+ D+    + 
Sbjct: 368 ----------------EGTR-ARSDKLHEL----------EKENLQLKAKLHDMEMERDM 400

Query: 163 LGEKQEELARKHARFVLSLNQTMEKKATTTVYINETYTKINLKRE-DIALQKKCIQEAEE 221
             +K EEL  ++    ++  Q+M++    ++++     +I+   E   A QK    E  E
Sbjct: 401 DRKKIEELMEENMTLEMAQKQSMDE----SLHLGWELEQISRTSELSEAPQKSLGHEVNE 456

Query: 222 LMEKERAEYLIRKQELTAQINEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAA 281
           L      +  +  Q LT  + E   T  V  +E    K        KM K  + ++    
Sbjct: 457 LTSSRLLKLEMENQSLTKTVEELRTT--VDSVEGNASK------ILKMEKENQRLSKKVE 508

Query: 282 VLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKE---KLDDISNDEKNE 338
           +L +   EI +  +S++  +    +L K+ A LE  +    +N E   K+ +  N+  N+
Sbjct: 509 ILEN---EIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQ 565

Query: 339 FLNKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTF 398
            ++ ++Q  +    AR+  KD+ ++ K L    K   S+  K   +K++I    +K+L  
Sbjct: 566 TVSSLRQRSQISAEARV--KDIEKENKILHESIKETSSKLSKIEFEKRQI----KKELEH 619

Query: 399 ISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQ--QQIKILSANLERESQRCVIT- 455
             +K     +   ++ ++E+    LQ+     K   +  + ++  ++ LERE+++   T 
Sbjct: 620 YKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTL 679

Query: 456 ------QWKMACLRKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFV 509
                  +++  L K++++   +   E++   E ++ A ++  +L  E    + E     
Sbjct: 680 DSFKNLTFQLESLEKENSQLDEE-NLELRRNVESLKCASMKMAQLQLENKELESEKEQLK 738

Query: 510 AQIEKLTTELKEEEKAFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAE 569
             +E L    K+ E+  V+ + +        E   +++T  N  K+ + +E   +LQ  E
Sbjct: 739 KGLELLKASFKKTERLEVSYQGL------DIENQRLQKTLENSNKKIQQLE--SELQDLE 790

Query: 570 QEYKEKRRKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQQLRDQES 629
            E +  ++ LEEL   I+++R E+               +   ++E    +L++ + Q  
Sbjct: 791 MENQTLQKNLEELK--ISSKRLEQ-------------LEKENKSLEQETSQLEKDKKQLE 835

Query: 630 KKNKDHFETLKNLENGFYINDQKADLLLLENKKLKEYILYLKNNIEKYREGQEALMHTSN 689
           K+NK   +  +  +     N+ K   L  ENK L + I   K +  + +E ++       
Sbjct: 836 KENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKE------ 889

Query: 690 DLSRQLIAQEAQYKDLWAEFQTTVKILVDNGEETL--QDINNLTDKLRERDEKMQHVSTW 747
             +++L+      K    + +T V +  D   E L  Q +NN  +KL    EK+      
Sbjct: 890 --NKELV------KRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKI------ 935

Query: 748 LRGSLEGLRLLVEQESPMD---LLSKQQLRALLVTS---KEEKTCQL 788
               L   RLL +++S  D    L + +L + L  S   KEEK   L
Sbjct: 936 ---GLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAAL 979



 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 102/532 (19%), Positives = 225/532 (42%), Gaps = 64/532 (12%)

Query: 65   EEAKIFLKDIAVAVKKLEEMRKATI-DLLEIESM--ELNKLYYLLETLPNSIKREL-EEC 120
            +E K  +K   + +K L  +R+  + + L+ + M  +L KL + LE +  + +R L +E 
Sbjct: 888  KENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQ 947

Query: 121  VRDARRLNLFEI---NTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARF 177
              D  R  L E    +T+K  +   E +I  L+ ++ + T YN+ L ++ + + + +   
Sbjct: 948  STDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYE-- 1005

Query: 178  VLSLNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKER--AEYLIRKQ 235
             L   Q  E+   ++  I+    K   +RE     ++ ++  + L+E ER  A     KQ
Sbjct: 1006 ALKQRQDEERMVQSSPPISGEDNK--WERESQETTRELLKVKDRLIEVERNNATLQAEKQ 1063

Query: 236  ELTAQINEFENTRE-------VKRMETYQKKKELDKLQTKMSKIK---ETVTVSAAVLSD 285
             L  Q+ + E             + +T   +++   LQT+ +K++    T+   +  L +
Sbjct: 1064 ALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMN 1123

Query: 286  HNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQ 345
             N ++     S+    + V + ++DL  L   L    +  E L +    E    ++K   
Sbjct: 1124 QNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGT 1183

Query: 346  LVETLHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYF 405
            L        +E++DL ++   L +Q   +   E+   ++++K+  EN+   T  ++ +  
Sbjct: 1184 LKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKL 1243

Query: 406  LSQKRVDIKNMEEGLITLQELQQATKTVY--QQQIKILSANLERESQRCVITQWKMACLR 463
              +   D  N      T  +L + T+ +    + +K L  N + E  R            
Sbjct: 1244 CGEN--DRLNH-----TYSQLLKETEVLQTDHKNLKSLLNNSKLEQTR------------ 1284

Query: 464  KKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEE 523
                     ++AE   + E+ Q  ++   +L N+              + +L   L+EE 
Sbjct: 1285 ---------LEAEFSKLKEQYQQLDITSTKLNNQCEL-----------LSQLKGNLEEEN 1324

Query: 524  KAFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEK 575
            +  +++ + LM +     E  ++   +   ++ + ++ L +L+  +++ +EK
Sbjct: 1325 RHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEK 1376


>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
          Length = 3907

 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 172/772 (22%), Positives = 325/772 (42%), Gaps = 119/772 (15%)

Query: 32  TLPSTLGSSVAVEALE---QLFVVEQSLQS------DYFKCNEEAKIFLKDIAVAVKKLE 82
           TL ++  SS A + L+   Q+   +Q L+       DY K  E       D  + +  L+
Sbjct: 250 TLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKE-------DFTMQISFLQ 302

Query: 83  EMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEECVRDARRLNLFEINTIKMRITRT 142
           E        +++  ME +K       + NS K E++E     +   + E+NT   +I   
Sbjct: 303 EK-------IKVYEMEQDK------KVENSNKEEIQE-----KETIIEELNT---KIIEE 341

Query: 143 ENEIELLKKKITDLTKYNEALGEKQEELARKHARFV---LSLNQTMEKKATTTVYINETY 199
           E +   LK K+T   K    LGE QE++ +K+       L L  + +K+  ++  I +  
Sbjct: 342 EKKTLELKDKLTTADKL---LGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLM 398

Query: 200 TKIN----------------LKREDIALQKKCIQEAEELMEKERAEYLIRKQELT----A 239
             +                 ++R +   Q+K  Q   EL E    + +  KQEL     A
Sbjct: 399 GTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMA 458

Query: 240 QINEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRY 299
           Q+ E +   + +     +    +   + ++  +   +      L D N +  +L E +  
Sbjct: 459 QMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGL 518

Query: 300 WEQEVSELKKDLAILEAKLCFFTDNKEKL------DDISNDEKNEFLNKIKQLVETLHAA 353
             +E   L++ L  L  +L F  +  ++        +   +E ++ L+ ++ L   + +A
Sbjct: 519 ILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSA 578

Query: 354 RMEYKDLREKMKTLARQYKI---VLSEEEKAFLQKQKIHDENQ-----KQLTFISQKEYF 405
               K+L  K +     YKI   +L +E+ A L +     E +      QL F  ++E  
Sbjct: 579 SESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEE-- 636

Query: 406 LSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSANLERESQRCVITQWKMACLRKK 465
           LS+ + D++   E  I +++L+      Y+QQI  L   +   SQ+    Q++   L  K
Sbjct: 637 LSKLKEDLEI--EHRINIEKLKDNLGIHYKQQIDGLQNEM---SQKIETMQFEKDNLITK 691

Query: 466 HARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKA 525
             +   +I ++++ + + + N++   + L         +I+    +IE L  E  E+EK 
Sbjct: 692 QNQLILEI-SKLKDLQQSLVNSKSEEMTL---------QINELQKEIEILRQE--EKEKG 739

Query: 526 FVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSNI 585
            + +E   ++EL    E+  K+    KEKE +L E   QL+      K++++ LE++  I
Sbjct: 740 TLEQE---VQELQLKTELLEKQM---KEKENDLQEKFAQLEAENSILKDEKKTLEDMLKI 793

Query: 586 ITAQRQEEDLL-------NNHIFLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFET 638
            T   QEE L+        +   ++ ++    I   ED+KQ+  QL ++  K+       
Sbjct: 794 HTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFA 853

Query: 639 LKNLENGFY-INDQKADLLLLENKKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIA 697
            KN E  +  + ++ A LL     K+K+ +   KN  E   + +   ++    L R    
Sbjct: 854 EKNFEVNYQELQEEYACLL-----KVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPT 908

Query: 698 QEAQYKDLWAEFQTTVKILVDNGEETLQDINNLTDKL----RERDEKMQHVS 745
                  ++ E +T V   ++ GE   +D   L +KL    RE+ E  Q +S
Sbjct: 909 TVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLS 960



 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 142/611 (23%), Positives = 263/611 (43%), Gaps = 113/611 (18%)

Query: 220 EELMEKERAEYLIRKQE-----LTAQINEFENTREVKRMETYQKKKELDKLQTKMSKIKE 274
           E L + +  E  I++++     LTA + +    ++    E  +  ++  KLQ +  +++ 
Sbjct: 188 EGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQA 247

Query: 275 TVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFFT------DNKEKL 328
           + T+  +  S    ++ +  + I   +Q++ E    L   + K   FT        K K+
Sbjct: 248 SETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKV 307

Query: 329 DDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKI-----VLSEEEKAFL 383
            ++  D+K E  NK +   +      +  K + E+ KTL  + K+     +L E ++  +
Sbjct: 308 YEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIV 367

Query: 384 QKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSA 443
           QK +     + +LT   QKE    Q   +IK +   + T++ELQ+      Q +  I+  
Sbjct: 368 QKNQEIKNMKLELTNSKQKE---RQSSEEIKQL---MGTVEELQKRNHKDSQFETDIVQ- 420

Query: 444 NLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQ 503
            +E+E+QR      K+  LR                       AE+  +        +Q+
Sbjct: 421 RMEQETQR------KLEQLR-----------------------AELDEMYGQQIVQMKQE 451

Query: 504 EISGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLP 563
            I   +AQ+E++ T  K E          +   L  Y  I V E QI     + +   + 
Sbjct: 452 LIRQHMAQMEEMKTRHKGE----------MENALRSYSNITVNEDQI-----KLMNVAIN 496

Query: 564 QLQVAEQEYKEKRRKLEELSNII-----TAQRQEEDLLNNHIFLFTRDFSRYISNMEDVK 618
           +L +  Q+   ++ KL+E   +I       QRQ EDL+          FSR     E ++
Sbjct: 497 ELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEE------LSFSR-----EQIQ 545

Query: 619 QELQQLRDQESKKNKDH--FETLKNLENGFY-INDQKADLLL-----LENKKLKEYILYL 670
           +  Q + +QESK N+ H    T+++L+      ++ + +L L     + N K+K  +L  
Sbjct: 546 RARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEK 605

Query: 671 KNN--IEKYREGQEALMHTSNDLSRQLIAQEAQ-----YKDLWAEFQTTVKILVDN-GEE 722
           + N  +++  E QEA +     L  QL+    +      +DL  E +  ++ L DN G  
Sbjct: 606 EKNAVLDRMAESQEAELER---LRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIH 662

Query: 723 TLQDINNLTDKLRERDEKMQHVSTWLRGSLEGLRLLVEQESPMDLLSK-QQLRALLVTSK 781
             Q I+ L +++ ++ E MQ          E   L+ +Q   +  +SK + L+  LV SK
Sbjct: 663 YKQQIDGLQNEMSQKIETMQ---------FEKDNLITKQNQLILEISKLKDLQQSLVNSK 713

Query: 782 -EEKTCQLSDL 791
            EE T Q+++L
Sbjct: 714 SEEMTLQINEL 724



 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 155/751 (20%), Positives = 308/751 (41%), Gaps = 112/751 (14%)

Query: 44   EALE-QLFVVEQSLQSDYFKCNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKL 102
            +ALE QL  + + L         E  +F ++I    +KLE+  K       I   +  ++
Sbjct: 2056 QALEKQLEKMRKFLDEQAIDREHERDVFQQEI----QKLEQQLKVVPRFQPISEHQTREV 2111

Query: 103  YYLLETLPNSIKRELEECVRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEA 162
                E L N +K + ++C        L     ++  I     EIE L+ ++ +L +    
Sbjct: 2112 ----EQLANHLKEKTDKCSE-----LLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLV 2162

Query: 163  LGEKQEELA-RKHARFVLSLNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEE 221
              +  +++  RKH   V +     + + +  V +      I+ K ++I   ++ +++  E
Sbjct: 2163 SADTFQKVEDRKHFGAVEA-----KPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFRE 2217

Query: 222  LMEKERAEYLIRKQELTAQINEFENTREVKRMETYQK--KKELDKLQTKMSKIKETVTVS 279
             +E +  E  +++  +  +I + E+T  ++ +E   K  K +++KL      IKE+  +S
Sbjct: 2218 ELENKNEE--VQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLA---IKESDAMS 2272

Query: 280  AAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEF 339
                 D ++   +  + I+  E E+ +L + +  L+ +L   TDNK        +EKNE 
Sbjct: 2273 T---QDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVI------EEKNEL 2323

Query: 340  LNKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFI 399
            +                 +DL  +++ L    + V    E+   Q  ++ ++ Q++L  I
Sbjct: 2324 I-----------------RDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANI 2366

Query: 400  SQKE----YFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSANLERESQRCVIT 455
             QK     + LS++   +K+  + +I       A K   +QQ++  +AN E    + V+ 
Sbjct: 2367 GQKTSMNAHSLSEEADSLKHQLDVVI-------AEKLALEQQVE--TANEEMTFMKNVLK 2417

Query: 456  QWKMACLRKKHARWTAKIKAE----IQAITEKIQNAEVRRIE-----------------L 494
            +      +     ++ K + E    IQ+I E   N  +  +                  L
Sbjct: 2418 ETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSL 2477

Query: 495  LNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKML---------MKELSKYEEIFV 545
             N+T F+  E +G    I  L T L + E     K+  L         M+E  ++E   +
Sbjct: 2478 ENQTYFKSFEENG-KGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEML 2536

Query: 546  KETQINKEK---EEELVEYLPQLQV-AEQEYKEKRRKLEELS------NIITAQRQEEDL 595
            ++  +N +K   E+     + Q+Q+ A QEY +  +  + +S      NI    +  ED 
Sbjct: 2537 QKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDE 2596

Query: 596  LNNHIFLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNL-ENGFYINDQKAD 654
            L + I   T   S   S + ++   L   ++Q     K+  E  K L E    +   +  
Sbjct: 2597 LGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKK 2656

Query: 655  LLLLENKKLKEYILYLKNNIEKYREGQEA-LMHTSNDLSRQLIAQEAQ---YKDLWAEFQ 710
                E K+  + +  LK   E +   +E+   +    L  + +A +A+   YK+   + Q
Sbjct: 2657 QREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQ 2716

Query: 711  TTVKILVDNGEETLQDINNLTDKLRERDEKM 741
              + +   N     +D++ + D L E  EK+
Sbjct: 2717 EELLVKETNMTSLQKDLSQVRDHLAEAKEKL 2747



 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 148/746 (19%), Positives = 311/746 (41%), Gaps = 84/746 (11%)

Query: 71   LKDIAVAVKKLEEMRKATIDLLEIESMELNKL-YYLLETLPNSIKRELE-----ECVRD- 123
            L+++    ++++E R+      E    E   +   LL+     +K +LE     E VRD 
Sbjct: 1959 LQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDD 2018

Query: 124  -ARRLNLFEINTIKMRITRTENEIELLKKKIT---DLTKYNEALGEKQEELARKHARFVL 179
              +++   EI+ ++ +++R    IEL ++K T   DL + N+AL EKQ E  RK      
Sbjct: 2019 LQKQVKALEID-VEEQVSRF---IELEQEKNTELMDLRQQNQAL-EKQLEKMRKF----- 2068

Query: 180  SLNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTA 239
                 ++++A    +  + + +   K E         Q   E   +E  +     +E T 
Sbjct: 2069 -----LDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTD 2123

Query: 240  QINEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRY 299
            + +E   ++E  + +  ++ +E++KL+ ++ ++++ + VSA           R H     
Sbjct: 2124 KCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVE---DRKHFGAVE 2180

Query: 300  WEQEVS---ELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARME 356
             + E+S   +L+ +   ++ K    T+ +E+L+      + E  NK +++ +      ++
Sbjct: 2181 AKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQF----REELENKNEEVQQLHMQLEIQ 2236

Query: 357  YKDLREKMKTLARQYKIVLSEEEKAFLQ-KQKIHDENQKQLTFISQKEYFLSQKRVDIKN 415
             K+   +++ L ++ K+   + EK  L  K+      Q Q     +    + +K V+I  
Sbjct: 2237 KKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQ 2296

Query: 416  MEEGLITLQELQQATKTVYQQQIKILSAN--LERESQRCVITQWKMACLRKKHARWTAKI 473
            + E         Q TK   QQQ+KI + N  +E +++     + ++ CL           
Sbjct: 2297 LNE---------QVTK--LQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNR 2345

Query: 474  KAEIQAITEKIQNAEVRRIELLNETSFR----QQEISGFVAQIEKLTTE--LKEEEKAFV 527
            + EI+ + E I+  +     +  +TS       +E      Q++ +  E    E++    
Sbjct: 2346 EEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETA 2405

Query: 528  NKEKMLMKELSKYEEIFVKETQINKE-----KEEELVEYLPQL-----QVAEQEYKEKRR 577
            N+E   MK + K  E   K  Q+ +E     +E E VE +  +      VA     + + 
Sbjct: 2406 NEEMTFMKNVLK--ETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKP 2463

Query: 578  KLE---------ELSNIITAQRQEEDLLNNHIFLFTR--DFSRYISNME-DVKQELQQLR 625
            +LE          L N    +  EE+   + I L TR       +S  + ++ Q  +Q++
Sbjct: 2464 ELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIK 2523

Query: 626  DQESKKNKDHFETLKNLENGFYINDQKADLLLLENKKL---KEYILYLKNNIEKYREGQE 682
            D + +   +     K + N   I ++K    L+   +L   +EY  + ++N     E + 
Sbjct: 2524 DMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPER 2583

Query: 683  ALMHTSNDLSRQLIAQEAQYKDL-WAEFQTTVKILVDNGEETLQDINNLTDKLRERDEKM 741
              +   N L    +  +     L  +E ++ V  +  +     + +      + E+++K+
Sbjct: 2584 TNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKL 2643

Query: 742  QHVSTWLRGSLEGLRLLVEQESPMDL 767
              +   L G+ +  R   ++ SP D+
Sbjct: 2644 LELQKLLEGNEKKQREKEKKRSPQDV 2669



 Score = 57.4 bits (137), Expect = 5e-08
 Identities = 123/647 (19%), Positives = 264/647 (40%), Gaps = 71/647 (10%)

Query: 178  VLSLNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQEL 237
            VL++++ M  K  T +     + +I++   D + Q    +E  E M +E    L+R+ + 
Sbjct: 1545 VLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQE----LVRQYQE 1600

Query: 238  TAQINEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESI 297
              Q  E      +++ME  +++++ ++LQ ++ ++   +   +++  + NL    + E  
Sbjct: 1601 HQQATELLRQAHMRQME--RQREDQEQLQEEIKRLNRQLAQRSSI-DNENL----VSERE 1653

Query: 298  RYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLN---KIKQL-------- 346
            R   +E+  LK+       KLC    N        N+ + E      K K+L        
Sbjct: 1654 RVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVP 1713

Query: 347  VETLHAARMEYKDLREKM-KTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYF 405
             E L   R   +    ++ K L    K   + EE        I D + K  +  S    +
Sbjct: 1714 PEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQS--SASLIW 1771

Query: 406  LSQKRVDIKNM---EEGLITLQELQQATKT-VYQQQIKILSANLERE---SQRCVITQWK 458
             S+    +K+    E   +T + +   + + + +  I + S   E     SQR V + + 
Sbjct: 1772 RSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFA 1831

Query: 459  MACLRKKHARWTAKIKAEIQAITEKI-----------QNAEVRRIELLNETSFRQQEISG 507
               +  ++      I + +QA  EK+           ++A+V + EL+ E+  ++QE + 
Sbjct: 1832 GTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATE 1891

Query: 508  FVAQIEKLTTELKEEEKAFVNKEKMLMKELSK--------------YEEIFVKETQINKE 553
             +   E+L   L EE +A     + L  ELSK              +E    ++T I   
Sbjct: 1892 SLKCQEELRERLHEESRA----REQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDR 1947

Query: 554  KEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISN 613
             E+EL+    +LQ  E E ++ + + E LS    A + E   +   +    ++  + +  
Sbjct: 1948 LEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLL---QETEKLMKE 2004

Query: 614  MEDVKQELQQLRDQESKKNKDHFETLKNLENGFYINDQKADLLLLENKKLKEYILYLKNN 673
              +V+ + +++RD   K+ K     ++   + F   +Q+ +  L++ ++  + +      
Sbjct: 2005 KLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEK 2064

Query: 674  IEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTTVKILVDNGEETLQDINNLTDK 733
            + K+ + Q        D+ +Q I +  Q   +   FQ          E   +++  L + 
Sbjct: 2065 MRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPI-------SEHQTREVEQLANH 2117

Query: 734  LRERDEKMQHVSTWLRGSLEGLRLLVEQESPMDLLSKQQLRALLVTS 780
            L+E+ +K   +          ++   E+   ++   ++  +ALLV++
Sbjct: 2118 LKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSA 2164



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 122/660 (18%), Positives = 272/660 (41%), Gaps = 84/660 (12%)

Query: 98   ELNKLYYLLETLPNSIKRELEECVRDARRLNLFEINTIKMRITRTENEIELLKKKITDLT 157
            E+  L+  +     ++KRE +E  + ++ L  + I   + ++   + E+  +K + T+L 
Sbjct: 3093 EIQALHAQMNGRKITLKRE-QESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQ 3151

Query: 158  KYNEALGEKQEELARKHARFVLSLNQTMEKK-------ATTTVYINETYTKINLKREDIA 210
            +   +      EL  + A+  L L  T++ +           + + +   +++L  + +A
Sbjct: 3152 EQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLA 3211

Query: 211  LQKKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVKRMETY-------QKKKELD 263
             ++K  +E +  +EKE+A+    ++    ++ + + + E ++           Q+K+ L+
Sbjct: 3212 SEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLN 3271

Query: 264  KLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFFTD 323
            + Q K+   +       +     NLE+  L ES +   +E+S        L A+L     
Sbjct: 3272 ESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDG 3331

Query: 324  NKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLSEE----E 379
              +    + ++   + L ++++ +E  H+  +E  +  EK K  + Q +  + ++     
Sbjct: 3332 TGQSRPPLPSE---DLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHR 3388

Query: 380  KAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIK 439
            K    +Q+ + E QK++  +  K   L Q++++ K  +   + L E Q+    + + Q +
Sbjct: 3389 KTLQTEQEANTEGQKKMHELQSKVEDL-QRQLEEKRQQVYKLDL-EGQRLQGIMQEFQKQ 3446

Query: 440  ILSANLERESQRCVI------TQWKMACLRKKHARWTAKIKAE----------------- 476
             L    +RES+R +       T W +   R ++     KI+ E                 
Sbjct: 3447 ELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGT 3506

Query: 477  ------------IQAITEKIQNAEVRRIELLN-ETS------FRQQEISGFVAQIEKLTT 517
                        +Q +  K+Q    +  E L  ET+      + Q+ I   + Q++KLT 
Sbjct: 3507 GCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTG 3566

Query: 518  ELKEEEKAFVNKE----KMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYK 573
            + + EE + V+       +  + L +  E+    +Q+ +EK  +L   + +L+   + Y+
Sbjct: 3567 Q-QGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEK-NDLRNMVMKLEEQIRWYR 3624

Query: 574  E--------KRRKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQQLR 625
            +         R  L   +NI      E+++ N       +   R  + +  +K EL+   
Sbjct: 3625 QTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDS 3684

Query: 626  DQESKKNKDHFETLKNLENGFYINDQKADLLLLENKKLKEYILYLKNNIEKYREGQEALM 685
              ++        TLK +  G Y+  +     L+  KK   Y+L L    ++  +   AL+
Sbjct: 3685 LLQTLSPDSEHVTLKRI-YGKYLRAESFRKALIYQKK---YLLLLLGGFQECEDATLALL 3740



 Score = 53.5 bits (127), Expect = 8e-07
 Identities = 130/619 (21%), Positives = 250/619 (40%), Gaps = 98/619 (15%)

Query: 21   AVSTGPSLELCTLPSTLGSSVAVEALEQLFVVEQSLQSDYFKCNEEAKIFLKDIAVAVKK 80
            AVS   S  L TL S LG         ++   ++    DY   NE+ +  L+D    V+ 
Sbjct: 1194 AVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPE--LQDYRYEVQD 1251

Query: 81   LEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEECVRDARRLNL----FEINTIK 136
             +E       LL   + E NKL  L   L     ++ +    +    NL     E  +I 
Sbjct: 1252 FQENMHT---LLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIH 1308

Query: 137  MRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFVLSLNQTMEKKATTTVYIN 196
             ++T  E+     K K++ L    +    K EE  ++    + SL Q +++         
Sbjct: 1309 SQMTNLEDIDVNHKSKLSSLQDLEKT---KLEEQVQELESLISSLQQQLKE--------- 1356

Query: 197  ETYTKINLKREDIALQKKCIQEAEELM--------------EKERAEY---LIRKQ---- 235
               T+ N + E   LQK+    +E  +              + +R  Y    ++K     
Sbjct: 1357 ---TEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGT 1413

Query: 236  -ELTAQINEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLH 294
             E + +    E T  VK +E    K+  ++L+ +++K    V VS ++      E++R+ 
Sbjct: 1414 IEFSGEFGVKEETNIVKLLE----KQYQEQLEEEVAK----VIVSMSIAFAQQTELSRIS 1465

Query: 295  ESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDE--------KNEFLNKIKQL 346
                  ++  +  K+  A+ + +  +F + K   D I            K EF    K+L
Sbjct: 1466 GG----KENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKEL 1521

Query: 347  VETLHAARMEYKDLREKMKTLARQYKIVLSEE----EKAFLQKQKIHDENQKQLTFISQK 402
             E      +   D  +  ++  +   + +SEE    +K F+ +Q IHDE     +  + +
Sbjct: 1522 GEHGKEILLSNSDPHDIPES--KDCVLTISEEMFSKDKTFIVRQSIHDEISVS-SMDASR 1578

Query: 403  EYFLSQKRVDIKNMEEGLI-TLQELQQATKTVYQQQIKILSANLERESQRCVITQWKMAC 461
            +  L++++  +++M + L+   QE QQAT+ + Q  ++ +    E + Q           
Sbjct: 1579 QLMLNEEQ--LEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQ----------- 1625

Query: 462  LRKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKE 521
            L+++  R   ++ A+  +I  +   +E  R+ L    + +Q  ++G     EKL  EL+ 
Sbjct: 1626 LQEEIKRLNRQL-AQRSSIDNENLVSERERVLLEELEALKQLSLAG----REKLCCELRN 1680

Query: 522  EEKAFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEE 581
                  N      +   + EE   KE +++++ E+   E L   + A Q  K   R L+ 
Sbjct: 1681 SSTQTQNGN----ENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQ--KANNRLLKI 1734

Query: 582  LSNIITAQRQEEDLLNNHI 600
            L  ++      E+ +  H+
Sbjct: 1735 LLEVVKTTAAVEETIGRHV 1753



 Score = 50.4 bits (119), Expect = 7e-06
 Identities = 78/336 (23%), Positives = 149/336 (44%), Gaps = 60/336 (17%)

Query: 504 EISG--FVAQIEKLTTELKEEEKAFVNKE------------KMLMKELS-KYEEIFVKET 548
           E++G  FV +  K T  L+EEE    +              +M+  EL+ K  EI     
Sbjct: 117 EVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEI----E 172

Query: 549 QINKEKEEELVEY----LPQLQVAEQEYKEKRRKLEEL-SNIITAQRQEEDLLNNHIFLF 603
           ++N+E EE  V Y    L QLQ  E   K++   + +L +N+  A+R++++ +       
Sbjct: 173 ELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETM------- 225

Query: 604 TRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNL---ENGFYINDQ---KADLLL 657
            R+F       + ++ + QQL+  E+ +N  H  T  +L   +     + Q   + D LL
Sbjct: 226 -REFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLL 284

Query: 658 LENKKLKE----YILYLKNNIEKYREGQEALMHTSN------------DLSRQLIAQEAQ 701
            + +K KE     I +L+  I+ Y   Q+  +  SN            +L+ ++I +E +
Sbjct: 285 EDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKK 344

Query: 702 YKDLWAEFQTTVKILVDNGEETL---QDINNLTDKLRERDEKMQHVS---TWLRGSLEGL 755
             +L  +  T  K+L +  E+ +   Q+I N+  +L    +K +  S     L G++E L
Sbjct: 345 TLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEEL 404

Query: 756 RLLVEQESPMDLLSKQQLRALLVTSKEEKTCQLSDL 791
           +    ++S  +    Q++        E+   +L ++
Sbjct: 405 QKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEM 440



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 142/672 (21%), Positives = 271/672 (40%), Gaps = 115/672 (17%)

Query: 76   VAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEE----------CVRDAR 125
            + + + EE  K T   LE E  EL     LLE      + +L+E           ++D +
Sbjct: 728  IEILRQEEKEKGT---LEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEK 784

Query: 126  RLNLFEINTIKMRITRTENEIEL--LKKKITDLT--KYNEALGEKQEELARKHARFVLSL 181
            +  L ++  I   +++ E  I L  +K K  D    K  E L E+ E+L ++     + L
Sbjct: 785  K-TLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQ----CIQL 839

Query: 182  NQTMEKKATTTVYINETYTKINLK--REDIALQKKCIQEAEELMEKERAEYLIRKQELTA 239
            N+ +EK+  T  +  + + ++N +  +E+ A   K   + E+   K+  EY  + + L  
Sbjct: 840  NEEIEKQRNTFSFAEKNF-EVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNE 898

Query: 240  QIN-EFENTREVKRM------------ETYQK----KKELDKLQTKMSKIKETVTVSAAV 282
            +++ +  N   VK              ET +     +K+  +L  K+   K      +  
Sbjct: 899  ELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQR 958

Query: 283  LSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNK 342
            LSD + ++ + H  I +  +EV  LK++   +  +         +L+ I N  + E +  
Sbjct: 959  LSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRC-------RELEIIINHNRAENVQS 1011

Query: 343  IKQLVETL------HAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQL 396
                V +L        +R     + +  K+   + KI++  E+K   +   + +E++++ 
Sbjct: 1012 CDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMV--EDKVSFENMTVGEESKQEQ 1069

Query: 397  TFISQ-----KEYFLS----------QKRVDIKNMEEGLITLQELQQ--ATKTVYQQQIK 439
              +       KE  L           QK +++   E+  + LQ   Q      VY   + 
Sbjct: 1070 LILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVD 1129

Query: 440  ILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETS 499
             +   +E E         K  C  K+           I A  EKI+  E+++I  L   +
Sbjct: 1130 QVREYMENEKD-------KALCSLKEEL---------IFAQEEKIK--ELQKIHQLELQT 1171

Query: 500  FRQQEISG----FVAQIEKLTTELKEEEKAFVNKEKMLMKELSKYEEIFVKETQINKEKE 555
             + QE           I KL   + EE   F+   + L   L +Y    +K  ++N E +
Sbjct: 1172 MKTQETGDEGKPLHLLIGKLQKAVSEECSYFL---QTLCSVLGEYYTPALK-CEVNAEDK 1227

Query: 556  EELVEYL-----PQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRY 610
            E   +Y+     P+LQ    E ++ +  +  L N +T +       N  + L TR    +
Sbjct: 1228 ENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEE------YNKLLVLQTRLSKIW 1281

Query: 611  ISNMEDVKQEL--QQLRDQESKKNKDHFETLKNLENGFYINDQK-ADLLLLENKKLKEYI 667
                + +K E   + L  +E++    H + + NLE+    +  K + L  LE  KL+E +
Sbjct: 1282 GQQTDGMKLEFGEENLPKEETEFLSIHSQ-MTNLEDIDVNHKSKLSSLQDLEKTKLEEQV 1340

Query: 668  LYLKNNIEKYRE 679
              L++ I   ++
Sbjct: 1341 QELESLISSLQQ 1352



 Score = 38.9 bits (89), Expect = 0.020
 Identities = 102/518 (19%), Positives = 200/518 (38%), Gaps = 93/518 (17%)

Query: 62   KCNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEECV 121
            +  E  K  L+D+  +++  ++       LLE +   LN+    +E+       +L E  
Sbjct: 3233 RSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSE-- 3290

Query: 122  RDARRLNL-FEINTIKMRITRTENEIELLKKKITDLTKYN------------EALGEKQE 168
               R L L   + + K+RI    + ++  ++    L   +            + L E Q+
Sbjct: 3291 EQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQK 3350

Query: 169  ELARKHARFVLSLNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKERA 228
            +L  KH+R V  LN+T + K      ++   T+  +++ D  + +K +Q  +E       
Sbjct: 3351 QLEEKHSRIVELLNETEKYK------LDSLQTRQQMEK-DRQVHRKTLQTEQE----ANT 3399

Query: 229  EYLIRKQELTAQINEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNL 288
            E   +  EL +++ + +   E KR + Y+   E  +LQ  M + ++             L
Sbjct: 3400 EGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQK-----------QEL 3448

Query: 289  EIARLHESIRYWEQEVSE-----LKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKI 343
            E     ES R   Q ++E     L  D           T N      I  + K     K+
Sbjct: 3449 EREEKRESRRILYQNLNEPTTWSLTSDR----------TRNWVLQQKIEGETKESNYAKL 3498

Query: 344  KQLVETLHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKE 403
             ++         E + +R+K++ +A + + VL ++    LQ +   DE+     FI  +E
Sbjct: 3499 IEMNGGGTGCNHELEMIRQKLQCVASKLQ-VLPQKASERLQFETADDED-----FIWVQE 3552

Query: 404  YFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSANLERESQRCVITQWKMACLR 463
                       N++E ++ LQ+L                   + E    V        L 
Sbjct: 3553 -----------NIDEIILQLQKL----------------TGQQGEEPSLVSPSTSCGSLT 3585

Query: 464  KKHARWTAKIKAEIQAITEK---IQNAEVR---RIELLNETSFRQQEISGFVAQIEKLTT 517
            ++  R  A++   I  +TE+   ++N  ++   +I    +T   +   S F         
Sbjct: 3586 ERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIE 3645

Query: 518  ELKEEEKAFVNKEKM-LMKELSKYE-EIFVKETQINKE 553
             +   EK   N+EK+ L K L + E E++  + ++  +
Sbjct: 3646 AIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRND 3683


>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
          Length = 3899

 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 172/772 (22%), Positives = 325/772 (42%), Gaps = 119/772 (15%)

Query: 32  TLPSTLGSSVAVEALE---QLFVVEQSLQS------DYFKCNEEAKIFLKDIAVAVKKLE 82
           TL ++  SS A + L+   Q+   +Q L+       DY K  E       D  + +  L+
Sbjct: 250 TLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKE-------DFTMQISFLQ 302

Query: 83  EMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEECVRDARRLNLFEINTIKMRITRT 142
           E        +++  ME +K       + NS K E++E     +   + E+NT   +I   
Sbjct: 303 EK-------IKVYEMEQDK------KVENSNKEEIQE-----KETIIEELNT---KIIEE 341

Query: 143 ENEIELLKKKITDLTKYNEALGEKQEELARKHARFV---LSLNQTMEKKATTTVYINETY 199
           E +   LK K+T   K    LGE QE++ +K+       L L  + +K+  ++  I +  
Sbjct: 342 EKKTLELKDKLTTADKL---LGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLM 398

Query: 200 TKIN----------------LKREDIALQKKCIQEAEELMEKERAEYLIRKQELT----A 239
             +                 ++R +   Q+K  Q   EL E    + +  KQEL     A
Sbjct: 399 GTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMA 458

Query: 240 QINEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRY 299
           Q+ E +   + +     +    +   + ++  +   +      L D N +  +L E +  
Sbjct: 459 QMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGL 518

Query: 300 WEQEVSELKKDLAILEAKLCFFTDNKEKL------DDISNDEKNEFLNKIKQLVETLHAA 353
             +E   L++ L  L  +L F  +  ++        +   +E ++ L+ ++ L   + +A
Sbjct: 519 ILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSA 578

Query: 354 RMEYKDLREKMKTLARQYKI---VLSEEEKAFLQKQKIHDENQ-----KQLTFISQKEYF 405
               K+L  K +     YKI   +L +E+ A L +     E +      QL F  ++E  
Sbjct: 579 SESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEE-- 636

Query: 406 LSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSANLERESQRCVITQWKMACLRKK 465
           LS+ + D++   E  I +++L+      Y+QQI  L   +   SQ+    Q++   L  K
Sbjct: 637 LSKLKEDLEI--EHRINIEKLKDNLGIHYKQQIDGLQNEM---SQKIETMQFEKDNLITK 691

Query: 466 HARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKA 525
             +   +I ++++ + + + N++   + L         +I+    +IE L  E  E+EK 
Sbjct: 692 QNQLILEI-SKLKDLQQSLVNSKSEEMTL---------QINELQKEIEILRQE--EKEKG 739

Query: 526 FVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSNI 585
            + +E   ++EL    E+  K+    KEKE +L E   QL+      K++++ LE++  I
Sbjct: 740 TLEQE---VQELQLKTELLEKQM---KEKENDLQEKFAQLEAENSILKDEKKTLEDMLKI 793

Query: 586 ITAQRQEEDLL-------NNHIFLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFET 638
            T   QEE L+        +   ++ ++    I   ED+KQ+  QL ++  K+       
Sbjct: 794 HTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFA 853

Query: 639 LKNLENGFY-INDQKADLLLLENKKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIA 697
            KN E  +  + ++ A LL     K+K+ +   KN  E   + +   ++    L R    
Sbjct: 854 EKNFEVNYQELQEEYACLL-----KVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPT 908

Query: 698 QEAQYKDLWAEFQTTVKILVDNGEETLQDINNLTDKL----RERDEKMQHVS 745
                  ++ E +T V   ++ GE   +D   L +KL    RE+ E  Q +S
Sbjct: 909 TVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLS 960



 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 156/750 (20%), Positives = 306/750 (40%), Gaps = 118/750 (15%)

Query: 44   EALE-QLFVVEQSLQSDYFKCNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKL 102
            +ALE QL  + + L         E  +F ++I    +KLE+  K       I   +  ++
Sbjct: 2056 QALEKQLEKMRKFLDEQAIDREHERDVFQQEI----QKLEQQLKVVPRFQPISEHQTREV 2111

Query: 103  YYLLETLPNSIKRELEECVRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEA 162
                E L N +K + ++C        L     ++  I     EIE L+ ++ +L +    
Sbjct: 2112 ----EQLANHLKEKTDKCSE-----LLLSKEQLQRDIQERNEEIEKLEFRVRELEQ--AL 2160

Query: 163  LGEKQEELARKHARFVLSLNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEEL 222
            L E ++      A+  LSL   ++ +             I+ K ++I   ++ +++  E 
Sbjct: 2161 LVEDRKHFGAVEAKPELSLEVQLQAERDA----------IDRKEKEITNLEEQLEQFREE 2210

Query: 223  MEKERAEYLIRKQELTAQINEFENTREVKRMETYQK--KKELDKLQTKMSKIKETVTVSA 280
            +E +  E  +++  +  +I + E+T  ++ +E   K  K +++KL      IKE+  +S 
Sbjct: 2211 LENKNEE--VQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLA---IKESDAMST 2265

Query: 281  AVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFL 340
                D ++   +  + I+  E E+ +L + +  L+ +L   TDNK        +EKNE +
Sbjct: 2266 ---QDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVI------EEKNELI 2316

Query: 341  NKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFIS 400
                             +DL  +++ L    + V    E+   Q  ++ ++ Q++L  I 
Sbjct: 2317 -----------------RDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIG 2359

Query: 401  QKE----YFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSANLERESQRCVITQ 456
            QK     + LS++   +K+  + +I       A K   +QQ++  +AN E    + V+ +
Sbjct: 2360 QKTSMNAHSLSEEADSLKHQLDVVI-------AEKLALEQQVE--TANEEMTFMKNVLKE 2410

Query: 457  WKMACLRKKHARWTAKIKAE----IQAITEKIQNAEVRRIE-----------------LL 495
                  +     ++ K + E    IQ+I E   N  +  +                  L 
Sbjct: 2411 TNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLE 2470

Query: 496  NETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKML---------MKELSKYEEIFVK 546
            N+T F+  E +G    I  L T L + E     K+  L         M+E  ++E   ++
Sbjct: 2471 NQTYFKSFEENG-KGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQ 2529

Query: 547  ETQINKEK---EEELVEYLPQLQV-AEQEYKEKRRKLEELS------NIITAQRQEEDLL 596
            +  +N +K   E+     + Q+Q+ A QEY +  +  + +S      NI    +  ED L
Sbjct: 2530 KKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDEL 2589

Query: 597  NNHIFLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNL-ENGFYINDQKADL 655
             + I   T   S   S + ++   L   ++Q     K+  E  K L E    +   +   
Sbjct: 2590 GSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQ 2649

Query: 656  LLLENKKLKEYILYLKNNIEKYREGQEA-LMHTSNDLSRQLIAQEAQ---YKDLWAEFQT 711
               E K+  + +  LK   E +   +E+   +    L  + +A +A+   YK+   + Q 
Sbjct: 2650 REKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQE 2709

Query: 712  TVKILVDNGEETLQDINNLTDKLRERDEKM 741
             + +   N     +D++ + D L E  EK+
Sbjct: 2710 ELLVKETNMTSLQKDLSQVRDHLAEAKEKL 2739



 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 142/611 (23%), Positives = 263/611 (43%), Gaps = 113/611 (18%)

Query: 220 EELMEKERAEYLIRKQE-----LTAQINEFENTREVKRMETYQKKKELDKLQTKMSKIKE 274
           E L + +  E  I++++     LTA + +    ++    E  +  ++  KLQ +  +++ 
Sbjct: 188 EGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQA 247

Query: 275 TVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFFT------DNKEKL 328
           + T+  +  S    ++ +  + I   +Q++ E    L   + K   FT        K K+
Sbjct: 248 SETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKV 307

Query: 329 DDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKI-----VLSEEEKAFL 383
            ++  D+K E  NK +   +      +  K + E+ KTL  + K+     +L E ++  +
Sbjct: 308 YEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIV 367

Query: 384 QKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSA 443
           QK +     + +LT   QKE    Q   +IK +   + T++ELQ+      Q +  I+  
Sbjct: 368 QKNQEIKNMKLELTNSKQKE---RQSSEEIKQL---MGTVEELQKRNHKDSQFETDIVQ- 420

Query: 444 NLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQ 503
            +E+E+QR      K+  LR                       AE+  +        +Q+
Sbjct: 421 RMEQETQR------KLEQLR-----------------------AELDEMYGQQIVQMKQE 451

Query: 504 EISGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLP 563
            I   +AQ+E++ T  K E          +   L  Y  I V E QI     + +   + 
Sbjct: 452 LIRQHMAQMEEMKTRHKGE----------MENALRSYSNITVNEDQI-----KLMNVAIN 496

Query: 564 QLQVAEQEYKEKRRKLEELSNII-----TAQRQEEDLLNNHIFLFTRDFSRYISNMEDVK 618
           +L +  Q+   ++ KL+E   +I       QRQ EDL+          FSR     E ++
Sbjct: 497 ELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEE------LSFSR-----EQIQ 545

Query: 619 QELQQLRDQESKKNKDH--FETLKNLENGFY-INDQKADLLL-----LENKKLKEYILYL 670
           +  Q + +QESK N+ H    T+++L+      ++ + +L L     + N K+K  +L  
Sbjct: 546 RARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEK 605

Query: 671 KNN--IEKYREGQEALMHTSNDLSRQLIAQEAQ-----YKDLWAEFQTTVKILVDN-GEE 722
           + N  +++  E QEA +     L  QL+    +      +DL  E +  ++ L DN G  
Sbjct: 606 EKNAVLDRMAESQEAELER---LRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIH 662

Query: 723 TLQDINNLTDKLRERDEKMQHVSTWLRGSLEGLRLLVEQESPMDLLSK-QQLRALLVTSK 781
             Q I+ L +++ ++ E MQ          E   L+ +Q   +  +SK + L+  LV SK
Sbjct: 663 YKQQIDGLQNEMSQKIETMQ---------FEKDNLITKQNQLILEISKLKDLQQSLVNSK 713

Query: 782 -EEKTCQLSDL 791
            EE T Q+++L
Sbjct: 714 SEEMTLQINEL 724



 Score = 73.2 bits (178), Expect = 9e-13
 Identities = 137/669 (20%), Positives = 268/669 (40%), Gaps = 118/669 (17%)

Query: 81   LEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEECVRDARRLNLFEINTIKMRIT 140
            LE   +A  D ++ +  E+  L   LE     ++ + EE  +   +L + +  +   R+ 
Sbjct: 2179 LEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTT-RLQ 2237

Query: 141  RTENEIELLKKKITDLTKYNEALGEKQEELARKHARFVLSLNQTMEKKATTTVYINETYT 200
              E E +L K    D+ K   A+ E      +          Q +++K      +NE  T
Sbjct: 2238 ELEQENKLFKD---DMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVT 2294

Query: 201  KINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVKRMETYQKKK 260
            K+  + + I    K I+E  EL+          + ++   +++ E  +  +  E  Q  +
Sbjct: 2295 KLQQQLK-ITTDNKVIEEKNELIRD-------LETQIECLMSDQECVKRNREEEIEQLNE 2346

Query: 261  ELDKLQTKMSKIKETVTVSAAVLSD------HNLEIARLHESIRYWEQEVSELKKDLAIL 314
             ++KLQ +++ I +  +++A  LS+      H L++  + E +   EQ+V    +++  +
Sbjct: 2347 VIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVV-IAEKLAL-EQQVETANEEMTFM 2404

Query: 315  E--AKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEY--KDLREKMKTLARQ 370
            +   K   F  N+   +  S   + E + KI+ + E      +++  KD  E        
Sbjct: 2405 KNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPE-------- 2456

Query: 371  YKIVLSEEEKAFLQKQ---KIHDENQKQL-----TFISQKEYFLSQKRVDIKNMEEGLIT 422
             ++VL+E+    L+ Q   K  +EN K       T + Q E  +S K +++    + +  
Sbjct: 2457 LEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKD 2516

Query: 423  LQELQQATKTVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAITE 482
            +QE  Q    + Q++I  L   +E +    +++Q ++  +++      AK   + Q I+ 
Sbjct: 2517 MQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEY-----AKFCQDNQTIS- 2570

Query: 483  KIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSKYEE 542
                +E  R  + N    R+ E+    + I  LT  + E E   V               
Sbjct: 2571 ----SEPERTNIQNLNQLREDELG---SDISALTLRISELESQVVEMH------------ 2611

Query: 543  IFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHIFL 602
                 T +  EKE        Q+++AE+   EK +KL EL  ++    +++         
Sbjct: 2612 -----TSLILEKE--------QVEIAEKNVLEKEKKLLELQKLLEGNEKKQ--------- 2649

Query: 603  FTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNLENGFYINDQ-----KADLLL 657
                                  R++E K++    E LK     F+ N++     + + L 
Sbjct: 2650 ----------------------REKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALR 2687

Query: 658  LENKKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTTVKILV 717
             E+   K  +   K   EK +E  E L+  +N  S Q     +Q +D  AE +  + IL 
Sbjct: 2688 AESVATKAELASYKEKAEKLQE--ELLVKETNMTSLQ--KDLSQVRDHLAEAKEKLSILE 2743

Query: 718  DNGEETLQD 726
               E  +Q+
Sbjct: 2744 KEDETEVQE 2752



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 126/578 (21%), Positives = 233/578 (40%), Gaps = 75/578 (12%)

Query: 44   EALEQLFVVEQSLQSDYFKCNEEAKIFLKDIAVAVKKLEE--------MRKATIDLLEIE 95
            E LEQ     ++   +  + + + +I  K+    +++LE+        M K  + + E +
Sbjct: 2202 EQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESD 2261

Query: 96   SMELNKLYYLLETLPNSIKR---ELEECVRDARRLNLFEINTIKMRITRTENEIELLKKK 152
            +M     + L       I+    E+++      +L        +++IT     IE   + 
Sbjct: 2262 AMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQ------QLKITTDNKVIEEKNEL 2315

Query: 153  ITDLTKYNEALGEKQEELARKHARFVLSLNQTMEKKATTTVYINETYTKINLKREDIALQ 212
            I DL    E L   QE + R     +  LN+ +EK       I +   K ++    ++  
Sbjct: 2316 IRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQ---KTSMNAHSLS-- 2370

Query: 213  KKCIQEAEEL---MEKERAEYLIRKQELTAQINEFENTREVKRMETYQKKKELDKLQTKM 269
                +EA+ L   ++   AE L  +Q++     E    + V + ET  K  +L +    +
Sbjct: 2371 ----EEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLK-ETNFKMNQLTQELFSL 2425

Query: 270  SKIKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLD 329
             + +E+V    ++  ++++ +A  H S    E EV   +  L  LE +  F +  +    
Sbjct: 2426 KRERESVEKIQSI-PENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKG 2484

Query: 330  DISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIH 389
             I N E      ++ QL  T+ A  +E     +++K +  Q +      +K  +  QKI 
Sbjct: 2485 SIINLE-----TRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIV 2539

Query: 390  DE-------NQKQLTFISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILS 442
            +E       +Q QL  + +   F    +      E     +Q L Q  +      I  L+
Sbjct: 2540 EEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPER--TNIQNLNQLREDELGSDISALT 2597

Query: 443  ANL-ERESQ-----RCVITQWKMACLRKKHARWTAKIKAEIQAITE----KIQNAEVRR- 491
              + E ESQ       +I + +   + +K+     K   E+Q + E    K +  E +R 
Sbjct: 2598 LRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRS 2657

Query: 492  ---IELLNETS--FRQQEISGFVAQIEKLTTE---LKEEEKAFVNKEKMLMKELSKYEEI 543
               +E+L  T+  F   E SGF  ++E L  E    K E  ++  K + L       EE+
Sbjct: 2658 PQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQ------EEL 2711

Query: 544  FVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEE 581
             VKET +   +++     L Q++    E KEK   LE+
Sbjct: 2712 LVKETNMTSLQKD-----LSQVRDHLAEAKEKLSILEK 2744



 Score = 57.4 bits (137), Expect = 5e-08
 Identities = 123/649 (18%), Positives = 264/649 (40%), Gaps = 71/649 (10%)

Query: 178  VLSLNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQEL 237
            VL++++ M  K  T +     + +I++   D + Q    +E  E M +E    L+R+ + 
Sbjct: 1545 VLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQE----LVRQYQE 1600

Query: 238  TAQINEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESI 297
              Q  E      +++ME  +++++ ++LQ ++ ++   +   +++  + NL    + E  
Sbjct: 1601 HQQATELLRQAHMRQME--RQREDQEQLQEEIKRLNRQLAQRSSI-DNENL----VSERE 1653

Query: 298  RYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLN---KIKQL-------- 346
            R   +E+  LK+       KLC    N        N+ + E      K K+L        
Sbjct: 1654 RVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVP 1713

Query: 347  VETLHAARMEYKDLREKM-KTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYF 405
             E L   R   +    ++ K L    K   + EE        I D + K  +  S    +
Sbjct: 1714 PEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQS--SASLIW 1771

Query: 406  LSQKRVDIKNM---EEGLITLQELQQATKT-VYQQQIKILSANLERE---SQRCVITQWK 458
             S+    +K+    E   +T + +   + + + +  I + S   E     SQR V + + 
Sbjct: 1772 RSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFA 1831

Query: 459  MACLRKKHARWTAKIKAEIQAITEKI-----------QNAEVRRIELLNETSFRQQEISG 507
               +  ++      I + +QA  EK+           ++A+V + EL+ E+  ++QE + 
Sbjct: 1832 GTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATE 1891

Query: 508  FVAQIEKLTTELKEEEKAFVNKEKMLMKELSK--------------YEEIFVKETQINKE 553
             +   E+L   L EE +A     + L  ELSK              +E    ++T I   
Sbjct: 1892 SLKCQEELRERLHEESRA----REQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDR 1947

Query: 554  KEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISN 613
             E+EL+    +LQ  E E ++ + + E LS    A + E   +   +    ++  + +  
Sbjct: 1948 LEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLL---QETEKLMKE 2004

Query: 614  MEDVKQELQQLRDQESKKNKDHFETLKNLENGFYINDQKADLLLLENKKLKEYILYLKNN 673
              +V+ + +++RD   K+ K     ++   + F   +Q+ +  L++ ++  + +      
Sbjct: 2005 KLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEK 2064

Query: 674  IEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTTVKILVDNGEETLQDINNLTDK 733
            + K+ + Q        D+ +Q I +  Q   +   FQ          E   +++  L + 
Sbjct: 2065 MRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPI-------SEHQTREVEQLANH 2117

Query: 734  LRERDEKMQHVSTWLRGSLEGLRLLVEQESPMDLLSKQQLRALLVTSKE 782
            L+E+ +K   +          ++   E+   ++   ++  +ALLV  ++
Sbjct: 2118 LKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRK 2166



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 122/660 (18%), Positives = 272/660 (41%), Gaps = 84/660 (12%)

Query: 98   ELNKLYYLLETLPNSIKRELEECVRDARRLNLFEINTIKMRITRTENEIELLKKKITDLT 157
            E+  L+  +     ++KRE +E  + ++ L  + I   + ++   + E+  +K + T+L 
Sbjct: 3085 EIQALHAQMNGRKITLKRE-QESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQ 3143

Query: 158  KYNEALGEKQEELARKHARFVLSLNQTMEKK-------ATTTVYINETYTKINLKREDIA 210
            +   +      EL  + A+  L L  T++ +           + + +   +++L  + +A
Sbjct: 3144 EQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLA 3203

Query: 211  LQKKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVKRMETY-------QKKKELD 263
             ++K  +E +  +EKE+A+    ++    ++ + + + E ++           Q+K+ L+
Sbjct: 3204 SEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLN 3263

Query: 264  KLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFFTD 323
            + Q K+   +       +     NLE+  L ES +   +E+S        L A+L     
Sbjct: 3264 ESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDG 3323

Query: 324  NKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLSEE----E 379
              +    + ++   + L ++++ +E  H+  +E  +  EK K  + Q +  + ++     
Sbjct: 3324 TGQSRPPLPSE---DLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHR 3380

Query: 380  KAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIK 439
            K    +Q+ + E QK++  +  K   L Q++++ K  +   + L E Q+    + + Q +
Sbjct: 3381 KTLQTEQEANTEGQKKMHELQSKVEDL-QRQLEEKRQQVYKLDL-EGQRLQGIMQEFQKQ 3438

Query: 440  ILSANLERESQRCVI------TQWKMACLRKKHARWTAKIKAE----------------- 476
             L    +RES+R +       T W +   R ++     KI+ E                 
Sbjct: 3439 ELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGT 3498

Query: 477  ------------IQAITEKIQNAEVRRIELLN-ETS------FRQQEISGFVAQIEKLTT 517
                        +Q +  K+Q    +  E L  ET+      + Q+ I   + Q++KLT 
Sbjct: 3499 GCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTG 3558

Query: 518  ELKEEEKAFVNKE----KMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYK 573
            + + EE + V+       +  + L +  E+    +Q+ +EK  +L   + +L+   + Y+
Sbjct: 3559 Q-QGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEK-NDLRNMVMKLEEQIRWYR 3616

Query: 574  E--------KRRKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQQLR 625
            +         R  L   +NI      E+++ N       +   R  + +  +K EL+   
Sbjct: 3617 QTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDS 3676

Query: 626  DQESKKNKDHFETLKNLENGFYINDQKADLLLLENKKLKEYILYLKNNIEKYREGQEALM 685
              ++        TLK +  G Y+  +     L+  KK   Y+L L    ++  +   AL+
Sbjct: 3677 LLQTLSPDSEHVTLKRI-YGKYLRAESFRKALIYQKK---YLLLLLGGFQECEDATLALL 3732



 Score = 53.5 bits (127), Expect = 8e-07
 Identities = 130/619 (21%), Positives = 250/619 (40%), Gaps = 98/619 (15%)

Query: 21   AVSTGPSLELCTLPSTLGSSVAVEALEQLFVVEQSLQSDYFKCNEEAKIFLKDIAVAVKK 80
            AVS   S  L TL S LG         ++   ++    DY   NE+ +  L+D    V+ 
Sbjct: 1194 AVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPE--LQDYRYEVQD 1251

Query: 81   LEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEECVRDARRLNL----FEINTIK 136
             +E       LL   + E NKL  L   L     ++ +    +    NL     E  +I 
Sbjct: 1252 FQENMHT---LLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIH 1308

Query: 137  MRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFVLSLNQTMEKKATTTVYIN 196
             ++T  E+     K K++ L    +    K EE  ++    + SL Q +++         
Sbjct: 1309 SQMTNLEDIDVNHKSKLSSLQDLEKT---KLEEQVQELESLISSLQQQLKE--------- 1356

Query: 197  ETYTKINLKREDIALQKKCIQEAEELM--------------EKERAEY---LIRKQ---- 235
               T+ N + E   LQK+    +E  +              + +R  Y    ++K     
Sbjct: 1357 ---TEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGT 1413

Query: 236  -ELTAQINEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLH 294
             E + +    E T  VK +E    K+  ++L+ +++K    V VS ++      E++R+ 
Sbjct: 1414 IEFSGEFGVKEETNIVKLLE----KQYQEQLEEEVAK----VIVSMSIAFAQQTELSRIS 1465

Query: 295  ESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDE--------KNEFLNKIKQL 346
                  ++  +  K+  A+ + +  +F + K   D I            K EF    K+L
Sbjct: 1466 GG----KENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKEL 1521

Query: 347  VETLHAARMEYKDLREKMKTLARQYKIVLSEE----EKAFLQKQKIHDENQKQLTFISQK 402
             E      +   D  +  ++  +   + +SEE    +K F+ +Q IHDE     +  + +
Sbjct: 1522 GEHGKEILLSNSDPHDIPES--KDCVLTISEEMFSKDKTFIVRQSIHDEISVS-SMDASR 1578

Query: 403  EYFLSQKRVDIKNMEEGLI-TLQELQQATKTVYQQQIKILSANLERESQRCVITQWKMAC 461
            +  L++++  +++M + L+   QE QQAT+ + Q  ++ +    E + Q           
Sbjct: 1579 QLMLNEEQ--LEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQ----------- 1625

Query: 462  LRKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKE 521
            L+++  R   ++ A+  +I  +   +E  R+ L    + +Q  ++G     EKL  EL+ 
Sbjct: 1626 LQEEIKRLNRQL-AQRSSIDNENLVSERERVLLEELEALKQLSLAG----REKLCCELRN 1680

Query: 522  EEKAFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEE 581
                  N      +   + EE   KE +++++ E+   E L   + A Q  K   R L+ 
Sbjct: 1681 SSTQTQNGN----ENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQ--KANNRLLKI 1734

Query: 582  LSNIITAQRQEEDLLNNHI 600
            L  ++      E+ +  H+
Sbjct: 1735 LLEVVKTTAAVEETIGRHV 1753



 Score = 50.4 bits (119), Expect = 7e-06
 Identities = 78/336 (23%), Positives = 149/336 (44%), Gaps = 60/336 (17%)

Query: 504 EISG--FVAQIEKLTTELKEEEKAFVNKE------------KMLMKELS-KYEEIFVKET 548
           E++G  FV +  K T  L+EEE    +              +M+  EL+ K  EI     
Sbjct: 117 EVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEI----E 172

Query: 549 QINKEKEEELVEY----LPQLQVAEQEYKEKRRKLEEL-SNIITAQRQEEDLLNNHIFLF 603
           ++N+E EE  V Y    L QLQ  E   K++   + +L +N+  A+R++++ +       
Sbjct: 173 ELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETM------- 225

Query: 604 TRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNL---ENGFYINDQ---KADLLL 657
            R+F       + ++ + QQL+  E+ +N  H  T  +L   +     + Q   + D LL
Sbjct: 226 -REFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLL 284

Query: 658 LENKKLKE----YILYLKNNIEKYREGQEALMHTSN------------DLSRQLIAQEAQ 701
            + +K KE     I +L+  I+ Y   Q+  +  SN            +L+ ++I +E +
Sbjct: 285 EDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKK 344

Query: 702 YKDLWAEFQTTVKILVDNGEETL---QDINNLTDKLRERDEKMQHVS---TWLRGSLEGL 755
             +L  +  T  K+L +  E+ +   Q+I N+  +L    +K +  S     L G++E L
Sbjct: 345 TLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEEL 404

Query: 756 RLLVEQESPMDLLSKQQLRALLVTSKEEKTCQLSDL 791
           +    ++S  +    Q++        E+   +L ++
Sbjct: 405 QKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEM 440



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 142/672 (21%), Positives = 271/672 (40%), Gaps = 115/672 (17%)

Query: 76   VAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEE----------CVRDAR 125
            + + + EE  K T   LE E  EL     LLE      + +L+E           ++D +
Sbjct: 728  IEILRQEEKEKGT---LEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEK 784

Query: 126  RLNLFEINTIKMRITRTENEIEL--LKKKITDLT--KYNEALGEKQEELARKHARFVLSL 181
            +  L ++  I   +++ E  I L  +K K  D    K  E L E+ E+L ++     + L
Sbjct: 785  K-TLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQ----CIQL 839

Query: 182  NQTMEKKATTTVYINETYTKINLK--REDIALQKKCIQEAEELMEKERAEYLIRKQELTA 239
            N+ +EK+  T  +  + + ++N +  +E+ A   K   + E+   K+  EY  + + L  
Sbjct: 840  NEEIEKQRNTFSFAEKNF-EVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNE 898

Query: 240  QIN-EFENTREVKRM------------ETYQK----KKELDKLQTKMSKIKETVTVSAAV 282
            +++ +  N   VK              ET +     +K+  +L  K+   K      +  
Sbjct: 899  ELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQR 958

Query: 283  LSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNK 342
            LSD + ++ + H  I +  +EV  LK++   +  +         +L+ I N  + E +  
Sbjct: 959  LSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRC-------RELEIIINHNRAENVQS 1011

Query: 343  IKQLVETL------HAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQL 396
                V +L        +R     + +  K+   + KI++  E+K   +   + +E++++ 
Sbjct: 1012 CDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMV--EDKVSFENMTVGEESKQEQ 1069

Query: 397  TFISQ-----KEYFLS----------QKRVDIKNMEEGLITLQELQQ--ATKTVYQQQIK 439
              +       KE  L           QK +++   E+  + LQ   Q      VY   + 
Sbjct: 1070 LILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVD 1129

Query: 440  ILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETS 499
             +   +E E         K  C  K+           I A  EKI+  E+++I  L   +
Sbjct: 1130 QVREYMENEKD-------KALCSLKEEL---------IFAQEEKIK--ELQKIHQLELQT 1171

Query: 500  FRQQEISG----FVAQIEKLTTELKEEEKAFVNKEKMLMKELSKYEEIFVKETQINKEKE 555
             + QE           I KL   + EE   F+   + L   L +Y    +K  ++N E +
Sbjct: 1172 MKTQETGDEGKPLHLLIGKLQKAVSEECSYFL---QTLCSVLGEYYTPALK-CEVNAEDK 1227

Query: 556  EELVEYL-----PQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRY 610
            E   +Y+     P+LQ    E ++ +  +  L N +T +       N  + L TR    +
Sbjct: 1228 ENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEE------YNKLLVLQTRLSKIW 1281

Query: 611  ISNMEDVKQEL--QQLRDQESKKNKDHFETLKNLENGFYINDQK-ADLLLLENKKLKEYI 667
                + +K E   + L  +E++    H + + NLE+    +  K + L  LE  KL+E +
Sbjct: 1282 GQQTDGMKLEFGEENLPKEETEFLSIHSQ-MTNLEDIDVNHKSKLSSLQDLEKTKLEEQV 1340

Query: 668  LYLKNNIEKYRE 679
              L++ I   ++
Sbjct: 1341 QELESLISSLQQ 1352



 Score = 38.9 bits (89), Expect = 0.020
 Identities = 102/518 (19%), Positives = 200/518 (38%), Gaps = 93/518 (17%)

Query: 62   KCNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEECV 121
            +  E  K  L+D+  +++  ++       LLE +   LN+    +E+       +L E  
Sbjct: 3225 RSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSE-- 3282

Query: 122  RDARRLNL-FEINTIKMRITRTENEIELLKKKITDLTKYN------------EALGEKQE 168
               R L L   + + K+RI    + ++  ++    L   +            + L E Q+
Sbjct: 3283 EQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQK 3342

Query: 169  ELARKHARFVLSLNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKERA 228
            +L  KH+R V  LN+T + K      ++   T+  +++ D  + +K +Q  +E       
Sbjct: 3343 QLEEKHSRIVELLNETEKYK------LDSLQTRQQMEK-DRQVHRKTLQTEQE----ANT 3391

Query: 229  EYLIRKQELTAQINEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNL 288
            E   +  EL +++ + +   E KR + Y+   E  +LQ  M + ++             L
Sbjct: 3392 EGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQK-----------QEL 3440

Query: 289  EIARLHESIRYWEQEVSE-----LKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKI 343
            E     ES R   Q ++E     L  D           T N      I  + K     K+
Sbjct: 3441 EREEKRESRRILYQNLNEPTTWSLTSDR----------TRNWVLQQKIEGETKESNYAKL 3490

Query: 344  KQLVETLHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKE 403
             ++         E + +R+K++ +A + + VL ++    LQ +   DE+     FI  +E
Sbjct: 3491 IEMNGGGTGCNHELEMIRQKLQCVASKLQ-VLPQKASERLQFETADDED-----FIWVQE 3544

Query: 404  YFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSANLERESQRCVITQWKMACLR 463
                       N++E ++ LQ+L                   + E    V        L 
Sbjct: 3545 -----------NIDEIILQLQKL----------------TGQQGEEPSLVSPSTSCGSLT 3577

Query: 464  KKHARWTAKIKAEIQAITEK---IQNAEVR---RIELLNETSFRQQEISGFVAQIEKLTT 517
            ++  R  A++   I  +TE+   ++N  ++   +I    +T   +   S F         
Sbjct: 3578 ERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIE 3637

Query: 518  ELKEEEKAFVNKEKM-LMKELSKYE-EIFVKETQINKE 553
             +   EK   N+EK+ L K L + E E++  + ++  +
Sbjct: 3638 AIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRND 3675


>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
            sapiens]
          Length = 1870

 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 175/811 (21%), Positives = 336/811 (41%), Gaps = 97/811 (11%)

Query: 40   SVAVEALEQLFVVE-QSLQSDYFKCNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIESME 98
            S  VE LE   V E QSLQ+    C   +K  +K+ A   K +E +R+ +   ++I   E
Sbjct: 504  SKKVEILENEIVQEKQSLQN----CQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQE 559

Query: 99   LNKLYYLLETLPNSIKRELEECVRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTK 158
               L   + +L    +   E  V+D  + N     +IK   ++  ++IE  K++I    +
Sbjct: 560  NEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKL-SKIEFEKRQIKKELE 618

Query: 159  YNEALGEKQEELARKHARFVLSLNQTMEKKATTTVYINETYTKIN-----LKREDIALQK 213
            + +  GE+ EEL  +    +   N+ ++KK T      E    +      L+RE+  L+K
Sbjct: 619  HYKEKGERAEELENE-LHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKK 677

Query: 214  -----KCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVKRMETYQKKKELDKLQTK 268
                 K +    E +EKE ++      EL   +   +    +K  +   + KEL+  + +
Sbjct: 678  TLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLK-CASMKMAQLQLENKELESEKEQ 736

Query: 269  MSKIKETVTVS-------AAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFF 321
            + K  E +  S              ++E  RL +++    +++ +L+ +L  LE +    
Sbjct: 737  LKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTL 796

Query: 322  TDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKIV------- 374
              N E+L  IS+    +   + K L +       + K L ++ K L +Q +I        
Sbjct: 797  QKNLEELK-ISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEEN 855

Query: 375  ------LSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKR-VDIKNMEEGLITLQELQ 427
                  L +E K   ++  I+ E+  +L  + ++   L ++  +DIK     L+TL+E  
Sbjct: 856  NVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKT----LVTLREDL 911

Query: 428  QATKTVYQQ----------QIKILSANLER--ESQRCVITQWKMACLRKKHARWTAKIKA 475
             + K   QQ          +++ +  N ER    ++    ++K+       ++  + +K 
Sbjct: 912  VSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLL-----ESKLESTLKK 966

Query: 476  EIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLMK 535
             ++   EKI   E R  E  N     +QE+       E L  + +++E+  V     +  
Sbjct: 967  SLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEAL--KQRQDEERMVQSSPPISG 1024

Query: 536  ELSKYEEIFVKETQINKEKEEELVEYLPQ---LQVAEQEYKEKRRKLEELSN-----IIT 587
            E +K+E    + T+   + ++ L+E       LQ  +Q  K + ++LE  +N     I+ 
Sbjct: 1025 EDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILA 1084

Query: 588  AQRQEEDLLNNHIFLFTRDFSRYISNM-------EDVKQELQQLRDQESKKNKDHF---- 636
             QRQ   L   +  L T++    + N          + Q  Q L  Q S +N++      
Sbjct: 1085 LQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKE 1144

Query: 637  -ETLKNLENGFYINDQKADLLLLENKKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQL 695
             E LK+L +    + +K +LL        E ++     ++   +  E       D   QL
Sbjct: 1145 REDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQL 1204

Query: 696  IAQEAQYKDLWAEFQT-TVKILVDNGEETLQDINNLTDKLRERDEKMQHVSTWLRGSLEG 754
            + Q+ Q +DL    +    K+L++N  +  + +     KL   ++++ H  + L    E 
Sbjct: 1205 LKQKGQLEDLEKMLKVEQEKMLLEN--KNHETVAAEYKKLCGENDRLNHTYSQLLKETEV 1262

Query: 755  LRLLVEQESPMDLLSKQQLRALLVTSKEEKT 785
            L+              + L++LL  SK E+T
Sbjct: 1263 LQ-----------TDHKNLKSLLNNSKLEQT 1282



 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 136/640 (21%), Positives = 276/640 (43%), Gaps = 95/640 (14%)

Query: 186 EKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQINEFE 245
           E +   +V + +   KI   R+++  + + + + ++ +E+   E    +QE    +++  
Sbjct: 244 ESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDAR 303

Query: 246 NTREVK-RMETYQKKK-ELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWEQE 303
           + R  +  ++  ++K   +DKL++++S+ KE                 RLH+ I +++  
Sbjct: 304 SARMYRDELDALREKAVRVDKLESEVSRYKE-----------------RLHD-IEFYKAR 345

Query: 304 VSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARME------- 356
           V ELK+D  +L        D  E     S D+ +E   +  QL   LH   ME       
Sbjct: 346 VEELKEDNQVLLETKTMLEDQLEGTRARS-DKLHELEKENLQLKAKLHDMEMERDMDRKK 404

Query: 357 YKDLREKMKTLARQYKIVLSE------EEKAFLQKQKIHDENQKQLTFISQKEYFLSQKR 410
            ++L E+  TL    K  + E      E +   +  ++ +  QK L    +     S + 
Sbjct: 405 IEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGH--EVNELTSSRL 462

Query: 411 VDIKNMEEGLI-TLQELQQATKTVYQQQIKILSANLERESQRCV---------ITQWKMA 460
           + ++   + L  T++EL+    +V     KIL   +E+E+QR           I Q K +
Sbjct: 463 LKLEMENQSLTKTVEELRTTVDSVEGNASKILK--MEKENQRLSKKVEILENEIVQEKQS 520

Query: 461 CLRKKH-ARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTEL 519
               ++ ++   K KA+++   E ++    R+I++L + +    +    + Q  +++ E 
Sbjct: 521 LQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEA 580

Query: 520 KEEEKAFVNK--EKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRR 577
           + ++    NK   + + +  SK  +I  ++ QI KE E                YKEK  
Sbjct: 581 RVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEH---------------YKEKGE 625

Query: 578 KLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFE 637
           + EEL N +    +E +LL   I     +       +E ++QE  +L ++E++K K   +
Sbjct: 626 RAEELENELHHLEKENELLQKKI----TNLKITCEKIEALEQENSEL-ERENRKLKKTLD 680

Query: 638 TLKNLENGFYINDQKADLLLLENKKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIA 697
           + KNL         + + L  EN +L E  L L+ N+E  +     +     + +++L +
Sbjct: 681 SFKNL-------TFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLE-NKELES 732

Query: 698 QEAQYKD----LWAEFQTTVKILV---------DNGEETLQDINNLTDKLRERDEKMQHV 744
           ++ Q K     L A F+ T ++ V            ++TL++ N    +L    + ++  
Sbjct: 733 EKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEME 792

Query: 745 STWLRGSLEGLRLLVEQESPMDLLSKQQLRALLVTSKEEK 784
           +  L+ +LE L++       ++ L K+       TS+ EK
Sbjct: 793 NQTLQKNLEELKI---SSKRLEQLEKENKSLEQETSQLEK 829



 Score = 74.7 bits (182), Expect = 3e-13
 Identities = 165/766 (21%), Positives = 322/766 (42%), Gaps = 119/766 (15%)

Query: 43  VEALEQLFVVEQSLQSDYFKCNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKL 102
           ++AL +  V    L+S+  +  E     L DI     ++EE+++    LLE ++M  ++L
Sbjct: 312 LDALREKAVRVDKLESEVSRYKER----LHDIEFYKARVEELKEDNQVLLETKTMLEDQL 367

Query: 103 YYLLETLPNSIKRELEECVRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEA 162
                           E  R AR   L E+          E E   LK K+ D+    + 
Sbjct: 368 ----------------EGTR-ARSDKLHEL----------EKENLQLKAKLHDMEMERDM 400

Query: 163 LGEKQEELARKHARFVLSLNQTMEKKATTTVYINETYTKINLKRE-DIALQKKCIQEAEE 221
             +K EEL  ++    ++  Q+M++    ++++     +I+   E   A QK    E  E
Sbjct: 401 DRKKIEELMEENMTLEMAQKQSMDE----SLHLGWELEQISRTSELSEAPQKSLGHEVNE 456

Query: 222 LMEKERAEYLIRKQELTAQINEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAA 281
           L      +  +  Q LT  + E   T  V  +E    K        KM K  + ++    
Sbjct: 457 LTSSRLLKLEMENQSLTKTVEELRTT--VDSVEGNASK------ILKMEKENQRLSKKVE 508

Query: 282 VLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKE---KLDDISNDEKNE 338
           +L +   EI +  +S++  +    +L K+ A LE  +    +N E   K+ +  N+  N+
Sbjct: 509 ILEN---EIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQ 565

Query: 339 FLNKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTF 398
            ++ ++Q  +    AR+  KD+ ++ K L    K   S+  K   +K++I    +K+L  
Sbjct: 566 TVSSLRQRSQISAEARV--KDIEKENKILHESIKETSSKLSKIEFEKRQI----KKELEH 619

Query: 399 ISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQ--QQIKILSANLERESQRCVIT- 455
             +K     +   ++ ++E+    LQ+     K   +  + ++  ++ LERE+++   T 
Sbjct: 620 YKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTL 679

Query: 456 ------QWKMACLRKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFV 509
                  +++  L K++++   +   E++   E ++ A ++  +L  E    + E     
Sbjct: 680 DSFKNLTFQLESLEKENSQLDEE-NLELRRNVESLKCASMKMAQLQLENKELESEKEQLK 738

Query: 510 AQIEKLTTELKEEEKAFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAE 569
             +E L    K+ E+  V+ + +        E   +++T  N  K+ + +E   +LQ  E
Sbjct: 739 KGLELLKASFKKTERLEVSYQGL------DIENQRLQKTLENSNKKIQQLE--SELQDLE 790

Query: 570 QEYKEKRRKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQQLRDQES 629
            E +  ++ LEEL   I+++R E+               +   ++E    +L++ + Q  
Sbjct: 791 MENQTLQKNLEELK--ISSKRLEQ-------------LEKENKSLEQETSQLEKDKKQLE 835

Query: 630 KKNKDHFETLKNLENGFYINDQKADLLLLENKKLKEYILYLKNNIEKYREGQEALMHTSN 689
           K+NK   +  +  +     N+ K   L  ENK L + I   K +  + +E ++       
Sbjct: 836 KENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKE------ 889

Query: 690 DLSRQLIAQEAQYKDLWAEFQTTVKILVDNGEETL--QDINNLTDKLRERDEKMQHVSTW 747
             +++L+      K    + +T V +  D   E L  Q +NN  +KL    EK+      
Sbjct: 890 --NKELV------KRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKI------ 935

Query: 748 LRGSLEGLRLLVEQESPMD--LLSKQQLRALLVTS---KEEKTCQL 788
               L   RLL +++S  D   L + +L + L  S   KEEK   L
Sbjct: 936 ---GLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAAL 978



 Score = 63.9 bits (154), Expect = 6e-10
 Identities = 100/531 (18%), Positives = 223/531 (41%), Gaps = 63/531 (11%)

Query: 65   EEAKIFLKDIAVAVKKLEEMRKATI-DLLEIESM--ELNKLYYLLETLPNSIKRELEECV 121
            +E K  +K   + +K L  +R+  + + L+ + M  +L KL + LE +  + +R L +  
Sbjct: 888  KENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQ 947

Query: 122  RDARRLNLFEI---NTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFV 178
                R  L E    +T+K  +   E +I  L+ ++ + T YN+ L ++ + + + +    
Sbjct: 948  STDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYE--A 1005

Query: 179  LSLNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKER--AEYLIRKQE 236
            L   Q  E+   ++  I+    K   +RE     ++ ++  + L+E ER  A     KQ 
Sbjct: 1006 LKQRQDEERMVQSSPPISGEDNK--WERESQETTRELLKVKDRLIEVERNNATLQAEKQA 1063

Query: 237  LTAQINEFENTRE-------VKRMETYQKKKELDKLQTKMSKIK---ETVTVSAAVLSDH 286
            L  Q+ + E             + +T   +++   LQT+ +K++    T+   +  L + 
Sbjct: 1064 LKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQ 1123

Query: 287  NLEIARLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQL 346
            N ++     S+    + V + ++DL  L   L    +  E L +    E    ++K   L
Sbjct: 1124 NAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTL 1183

Query: 347  VETLHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFL 406
                    +E++DL ++   L +Q   +   E+   ++++K+  EN+   T  ++ +   
Sbjct: 1184 KSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLC 1243

Query: 407  SQKRVDIKNMEEGLITLQELQQATKTVY--QQQIKILSANLERESQRCVITQWKMACLRK 464
             +   D  N      T  +L + T+ +    + +K L  N + E  R             
Sbjct: 1244 GEN--DRLNH-----TYSQLLKETEVLQTDHKNLKSLLNNSKLEQTR------------- 1283

Query: 465  KHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEK 524
                    ++AE   + E+ Q  ++   +L N+              + +L   L+EE +
Sbjct: 1284 --------LEAEFSKLKEQYQQLDITSTKLNNQCEL-----------LSQLKGNLEEENR 1324

Query: 525  AFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEK 575
              +++ + LM +     E  ++   +   ++ + ++ L +L+  +++ +EK
Sbjct: 1325 HLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEK 1375


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score = 94.7 bits (234), Expect = 3e-19
 Identities = 160/816 (19%), Positives = 344/816 (42%), Gaps = 99/816 (12%)

Query: 25   GPSLELCTLPSTLGSSVAVEALEQLFVVEQSLQSDYFKCNEEAKIFLKDIAVAVKKLEEM 84
            G S +L    + L + +A E   QL   E+ LQ+   +  EEA        +A+KK+ E+
Sbjct: 1055 GDSTDLSDQIAELQAQIA-ELKMQLAKKEEELQAALARVEEEAA----QKNMALKKIREL 1109

Query: 85   RKATIDL---LEIESMELNKLYYLLETLPN---SIKRELEECVRDARRLNLFEINTIKMR 138
                 +L   LE E    NK       L     ++K ELE+ +                 
Sbjct: 1110 ESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELR------- 1162

Query: 139  ITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFVLSLNQTMEKKATTTVYINET 198
             ++ E E+ +LKK + +  K +EA   + +E+ +KH++ V  L + +E+       + + 
Sbjct: 1163 -SKREQEVNILKKTLEEEAKTHEA---QIQEMRQKHSQAVEELAEQLEQTKRVKANLEKA 1218

Query: 199  YTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVKRMETYQK 258
               +  +R ++A + K + + +   E +R +   + QEL  + NE E  R        + 
Sbjct: 1219 KQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRT-------EL 1271

Query: 259  KKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKL 318
              ++ KLQ ++  +   ++ S +  S    + + L   ++  ++ + E  +    L  KL
Sbjct: 1272 ADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKL 1331

Query: 319  CFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMK------TLARQYK 372
                D K    +   +E+ E  + +++ + TLHA   +  D+++KM+        A + K
Sbjct: 1332 KQVEDEKNSFRE-QLEEEEEAKHNLEKQIATLHA---QVADMKKKMEDSVGCLETAEEVK 1387

Query: 373  IVLSEEEKAFLQKQK----IHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLITLQELQQ 428
              L ++ +   Q+ +     +D+ +K  T + Q+   L    VD+ +  +    L++ Q+
Sbjct: 1388 RKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQE---LDDLLVDLDHQRQSACNLEKKQK 1444

Query: 429  ATKTVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAITEKIQNAE 488
                +  ++ K +SA    E  R        A  R+K  +  +  +A  +A+ +K   AE
Sbjct: 1445 KFDQLLAEE-KTISAKYAEERDRA------EAEAREKETKALSLARALEEAMEQK---AE 1494

Query: 489  VRRI-----------------------ELLNETSFRQQEISGFVAQIEKLTTELKEEEKA 525
            + R+                       EL       +Q++     Q+E+L  EL+  E A
Sbjct: 1495 LERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDA 1554

Query: 526  FVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSNI 585
             +  E  L    +++E       + ++EK+++LV  + +++ AE E + K+R +     +
Sbjct: 1555 KLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREME-AELEDERKQRSMA----V 1609

Query: 586  ITAQRQEEDL--LNNHIFLFTRDFSRYISNMEDVKQELQQ-LRDQESKKNKDHFETLKNL 642
               ++ E DL  L  HI    ++    I  +  ++ +++  +R+ +  +        +  
Sbjct: 1610 AARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAK 1669

Query: 643  ENGFYINDQKADLLLLEN-----KKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIA 697
            EN   +   +A+++ L+      ++ K      ++ +             + +  R+L A
Sbjct: 1670 ENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEA 1729

Query: 698  QEAQYKDLWAEFQTTVKILVDNGEETLQDINNLTDKL---RERDEKMQHVSTWLRGSLEG 754
            + AQ ++   E Q   +++ D  ++    I+ +   L   R   +K ++    L    + 
Sbjct: 1730 RIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKE 1789

Query: 755  LRLLVEQESPMDLLSKQQLRALLVTSKEEKTCQLSD 790
            L++ +++   M+   K + +A  +T+ E K  QL +
Sbjct: 1790 LKVKLQE---MEGTVKSKYKA-SITALEAKIAQLEE 1821



 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 140/679 (20%), Positives = 289/679 (42%), Gaps = 102/679 (15%)

Query: 151  KKITDLTKYNEALGEKQEELARKHARFVLSLNQTMEKKATTTVYINETYTKINLKREDIA 210
            K +  +++  E +  K+EEL +   + + + N+  E +   +  + E   K+ L+ E + 
Sbjct: 835  KPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAE---KLQLQ-EQLQ 890

Query: 211  LQKKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVKRMETYQKKKELDKLQTKMS 270
             + +   EAEEL    RA    +KQEL    ++ E   E +       + E  K+Q  + 
Sbjct: 891  AETELCAEAEEL----RARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQ 946

Query: 271  KIKETVTVSAAVLSDHNLE-------IARLHESIRYWEQEVSELKKDLAILEAKLCFFTD 323
            +++E +    +      LE       + +L E     E +  +L K+  +LE ++  FT 
Sbjct: 947  ELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTT 1006

Query: 324  NKEKLDDISNDEKNEFLNKIKQLVETL-----HAARMEYKDLREKMKT----------LA 368
            N  +      +EK++ L K+K   E +        R E K  +E  KT          L+
Sbjct: 1007 NLTE-----EEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLS 1061

Query: 369  RQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLITLQELQQ 428
             Q   + ++  +  +Q  K  +E Q  L  + ++    +QK + +K + E    + ELQ+
Sbjct: 1062 DQIAELQAQIAELKMQLAKKEEELQAALARVEEE---AAQKNMALKKIRELESQISELQE 1118

Query: 429  ------ATKTVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAITE 482
                  A++   ++Q + L   LE        T    A  ++  ++   ++    + + E
Sbjct: 1119 DLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEE 1178

Query: 483  KIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSKYEE 542
            + +  E +  E+  + S   +E++  + Q +++   L++ ++   N+   L  E+    +
Sbjct: 1179 EAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEV----K 1234

Query: 543  IFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLL------ 596
            + ++    ++ K +++   L +LQV   ++ E  R   EL++ +T  + E D +      
Sbjct: 1235 VLLQGKGDSEHKRKKVEAQLQELQV---KFNEGERVRTELADKVTKLQVELDNVTGLLSQ 1291

Query: 597  -NNHIFLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNLENGFYINDQKADL 655
             ++     T+DFS   S ++D ++ LQ+                         N QK  L
Sbjct: 1292 SDSKSSKLTKDFSALESQLQDTQELLQE------------------------ENRQKLSL 1327

Query: 656  LLLENKKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTTVKI 715
                + KLK+    +++    +RE  E      ++L +Q+    AQ  D+  + + +V  
Sbjct: 1328 ----STKLKQ----VEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGC 1379

Query: 716  LVDNGEETLQDINNLTDKLRERDE-------KMQHVSTWLRGSLEGLRLLV--EQESPMD 766
            L +  EE  + +    + L +R E       K++   T L+  L+ L + +  +++S  +
Sbjct: 1380 L-ETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACN 1438

Query: 767  LLSKQQLRALLVTSKEEKT 785
            L  KQ+    L+   EEKT
Sbjct: 1439 LEKKQKKFDQLLA--EEKT 1455



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 142/709 (20%), Positives = 286/709 (40%), Gaps = 117/709 (16%)

Query: 65   EEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEECV--- 121
            EE +   + +    KK+++  +   + LE E     KL     T    +K+  EE +   
Sbjct: 925  EEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILE 984

Query: 122  ----RDARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARF 177
                + A+   L E    +     TE E +   K +  L   +EA+    EE  R+  + 
Sbjct: 985  DQNCKLAKEKKLLEDRIAEFTTNLTEEEEK--SKSLAKLKNKHEAMITDLEERLRREEKQ 1042

Query: 178  VLSLNQTMEKKATTTVYINETYT---------KINLKREDIALQKKCIQEAEELMEKERA 228
               L +T  K    +  +++            K+ L +++  LQ    +  EE  +K  A
Sbjct: 1043 RQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMA 1102

Query: 229  EYLIRKQELTAQINEFENTREVKRMETYQKKKEL----DKLQTKMSKIKETVTVSAAVLS 284
               IR  EL +QI+E +   E +R    + +K+     ++L+   +++++T+  +AA   
Sbjct: 1103 LKKIR--ELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAA--- 1157

Query: 285  DHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDE-KNEFLNKI 343
               L   R        EQEV+ LKK L           + + K  +    E + +    +
Sbjct: 1158 QQELRSKR--------EQEVNILKKTL-----------EEEAKTHEAQIQEMRQKHSQAV 1198

Query: 344  KQLVETLHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKE 403
            ++L E L   +    +L +  +TL  + +  L+ E K  LQ +   +  +K++    Q+ 
Sbjct: 1199 EELAEQLEQTKRVKANLEKAKQTLENE-RGELANEVKVLLQGKGDSEHKRKKVEAQLQE- 1256

Query: 404  YFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSANLERESQRCVITQWKMACLR 463
                   + +K  E   +  +   + TK   Q ++  ++  L +   +            
Sbjct: 1257 -------LQVKFNEGERVRTELADKVTK--LQVELDNVTGLLSQSDSK------------ 1295

Query: 464  KKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIE----KLTTEL 519
                  ++K+  +  A+  ++Q+ +    ELL E + ++  +S  + Q+E        +L
Sbjct: 1296 ------SSKLTKDFSALESQLQDTQ----ELLQEENRQKLSLSTKLKQVEDEKNSFREQL 1345

Query: 520  KEEEKAFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKL 579
            +EEE+A  N EK +    ++  ++        K+K E+ V     L+ AE+  ++ ++ L
Sbjct: 1346 EEEEEAKHNLEKQIATLHAQVADM--------KKKMEDSVGC---LETAEEVKRKLQKDL 1394

Query: 580  EELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETL 639
            E LS     QR EE +                  +E  K  LQQ  D          ++ 
Sbjct: 1395 EGLS-----QRHEEKV-------------AAYDKLEKTKTRLQQELDDLLVDLDHQRQSA 1436

Query: 640  KNLENGFYINDQKADLLLLENKKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIAQE 699
             NLE       +K D LL E K +       ++  E     +E    +      + + Q+
Sbjct: 1437 CNLEK----KQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQK 1492

Query: 700  AQYKDLWAEFQTTVKILVDNGEETLQDINNLTDKLRERDEKMQHVSTWL 748
            A+ + L  +F+T ++ L+ + ++  + ++ L    R  +++++ + T L
Sbjct: 1493 AELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQL 1541



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 94/488 (19%), Positives = 191/488 (39%), Gaps = 53/488 (10%)

Query: 340  LNKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFI 399
            L ++ +  E + A   E   +REK      +   + + + +   +K ++ ++ Q +    
Sbjct: 837  LLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELC 896

Query: 400  SQKEYFLSQKRVDIKNMEEGLITLQ----------ELQQATKTVYQQQIKILSANLERES 449
            ++ E   ++     + +EE    L+          +  QA K   QQ I+ L   LE E 
Sbjct: 897  AEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEE 956

Query: 450  QRCVITQWKMACLRKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFV 509
                         R+K        +A+++ + E+    E +  +L  E    +  I+ F 
Sbjct: 957  SA-----------RQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFT 1005

Query: 510  AQI------EKLTTELKEEEKAFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLP 563
              +       K   +LK + +A +   +  ++   K  +   K  +  +    +L + + 
Sbjct: 1006 TNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIA 1065

Query: 564  QLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQQ 623
            +LQ    E K +  K EE      A+ +EE    N      R+    IS +++  +  + 
Sbjct: 1066 ELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERA 1125

Query: 624  LRDQESKKNKDHFETLKNLENGFYIN-DQKADLLLLENKKLKEYILYLKNNIEKYREGQE 682
             R++  K+ +D  E L+ L+       D  A    L +K+ +E +  LK  +E+  +  E
Sbjct: 1126 SRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQE-VNILKKTLEEEAKTHE 1184

Query: 683  ALMHTSNDLSRQLIAQEAQYKDLWAEFQTTVKILVDNGEETLQDINNLTDKLRERDEKMQ 742
            A +        Q + + A+      E    VK  ++  ++TL++         ER E   
Sbjct: 1185 AQIQEMRQKHSQAVEELAEQ----LEQTKRVKANLEKAKQTLEN---------ERGELAN 1231

Query: 743  HVSTWLRGSLEGLRLLVEQESPMDLLSKQQLRALLVTSKEEKTCQLSDLVIPNYATNIQL 802
             V   L+G  +      + E+ +     Q+L+      +  +T +L+D V     T +Q+
Sbjct: 1232 EVKVLLQGKGDSEHKRKKVEAQL-----QELQVKFNEGERVRT-ELADKV-----TKLQV 1280

Query: 803  NIDTYLGL 810
             +D   GL
Sbjct: 1281 ELDNVTGL 1288


>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 750

 Score = 93.6 bits (231), Expect = 7e-19
 Identities = 131/646 (20%), Positives = 292/646 (45%), Gaps = 81/646 (12%)

Query: 112 SIKRELEECVRDARRLNLFEINTIKMRITRTENEIELLKKKITDL-TKYNEA---LGEKQ 167
           +++RELE  V   R L   +   ++M +  +++ ++ L+ +  DL ++ +++    GE +
Sbjct: 120 ALRRELEAQVHTIRILTC-QKTELQMALYYSQHAVKQLEGEARDLISRLHDSWKFAGELE 178

Query: 168 EELA------RKHARFVLSLNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEE 221
           + L+      +K  R++  L  T E+ A +      T T   LK ++  LQ+K      +
Sbjct: 179 QALSAVATQKKKADRYIEEL--TKERDALSLELYRNTITDEELKEKNAKLQEKL-----Q 231

Query: 222 LMEKERAEYLIRKQELTAQINEFENTREVKRM--ETYQKKKELDKLQTKMSKIKETVTVS 279
           L+E E++E  +  +EL  ++   +     +++  E     KEL  +  K+    E   + 
Sbjct: 232 LVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELW 291

Query: 280 AAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEF 339
             +      ++ R  E I+ WE+++ E ++ +   E K+    +   + +++  +++ + 
Sbjct: 292 NRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKM 351

Query: 340 LNKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFI 399
             + + + E     R + + + EK + + RQ +++  +EEK    ++K+H++ +     I
Sbjct: 352 RRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEK-----I 406

Query: 400 SQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSANLERESQRCVITQWKM 459
            ++E    +KR +    EE +   ++ Q+    +++Q+ KI      RE +  +  Q   
Sbjct: 407 REQE----EKRQE----EEKIREQEKRQEQEAKMWRQEEKI------REQEEKIREQ--- 449

Query: 460 ACLRKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTEL 519
               KK  R   KI  +     EKI+  E R+ +   E  +RQ+E             ++
Sbjct: 450 ---EKKMWRQEEKIHEQ-----EKIREEEKRQEQ---EEMWRQEE-------------KI 485

Query: 520 KEEEKAFVNKEKMLMKE--LSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRR 577
            E+E+ +  KEKM  +E  + K EE   ++ +  +E+EE++ E   ++   E++ +E+  
Sbjct: 486 HEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEE 545

Query: 578 KLEELSNIITAQR-QEEDLLNNHIFLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHF 636
              E   +   ++  EE+          R   +     E V ++ +++R+QE K+ +   
Sbjct: 546 MWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEE 605

Query: 637 ETLKNLENGFYINDQKADLLLLENKKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLI 696
           +  K  E    I +Q+ + +  + +K++E    ++   E  +E +E +      +  Q  
Sbjct: 606 KMWKQEEK---IREQE-EKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEE 661

Query: 697 AQEAQYKDLWAEFQTTVKILVDNGEETLQDINNLTDKLRERDEKMQ 742
             + Q + +W + +           E  + I    +K+RE++E MQ
Sbjct: 662 KMQEQEETMWRQEEKI--------REQEKKIREQEEKIREQEEMMQ 699



 Score = 86.7 bits (213), Expect = 8e-17
 Identities = 107/554 (19%), Positives = 245/554 (44%), Gaps = 47/554 (8%)

Query: 88  TIDLLEIESMELNKLYYLLETLPNSIKRELEECVRDARRLNLF-EINTIKMRITRTENEI 146
           T + L+ ++ +L +   L+E+  + I+  ++E  R   R  L      ++        E+
Sbjct: 215 TDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKEL 274

Query: 147 ELLKKKITDLTKYNEALGEKQEELARKHARFVLSLNQTMEKKATTTVYINETYTKINLKR 206
           + +  K+    + NE      ++   K  R    + +  EK       I E   KI  + 
Sbjct: 275 QSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQE 334

Query: 207 EDIALQKKCIQEAEELMEK------ERAEYLIRKQELTAQINEFENTREVKRMETYQKKK 260
           E +  Q++ + E EE M +      E+ E + R++E+  +  E    +E    E  +K +
Sbjct: 335 EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIR 394

Query: 261 ELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCF 320
           EL++   +  KI+E          +   E  ++ E  +  EQE    +++  I       
Sbjct: 395 ELEEKMHEQEKIREQ--------EEKRQEEEKIREQEKRQEQEAKMWRQEEKI------- 439

Query: 321 FTDNKEKLDDISNDEKNEFLNKIKQLVETLHAA-RMEYKDLREKMKTLARQYKIVLSEEE 379
               +E+ + I   EK     K+ +  E +H   ++  ++ R++ + + RQ + +  E+E
Sbjct: 440 ----REQEEKIREQEK-----KMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKI-HEQE 489

Query: 380 KAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIK 439
           + + QK+K+H++ +K    I ++E  + ++   I+  EE +   +E     +   ++Q +
Sbjct: 490 EIWRQKEKMHEQEEK----IRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEE 545

Query: 440 ILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAI---TEKIQNAEVRRIELLN 496
           +     +   Q  +  + K      K  R   KI+ + + +    EKI+  E +R E   
Sbjct: 546 MWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEE 605

Query: 497 ETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSKYEEIFVKETQINKEKEE 556
           +   ++++I     +I++   +++E+E+    +E+M  ++    EE   ++ +   E+EE
Sbjct: 606 KMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQ----EEKMGEQEEKMCEQEE 661

Query: 557 ELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMED 616
           ++ E    +   E++ +E+ +K+ E    I   R++E+++            +     E 
Sbjct: 662 KMQEQEETMWRQEEKIREQEKKIREQEEKI---REQEEMMQEQEEKMWEQEEKMCEQEEK 718

Query: 617 VKQELQQLRDQESK 630
           ++++ +++R QE K
Sbjct: 719 MQEQEEKMRRQEEK 732



 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 119/583 (20%), Positives = 248/583 (42%), Gaps = 86/583 (14%)

Query: 217 QEAEELMEKERAEYLIRKQELTAQINEFENTREVKRMETYQKK-----KELDKLQTKMSK 271
           Q A + +E E  + + R  +      E E    +  + T +KK     +EL K +  +S 
Sbjct: 150 QHAVKQLEGEARDLISRLHDSWKFAGELEQA--LSAVATQKKKADRYIEELTKERDALSL 207

Query: 272 IKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDI 331
                T++   L + N   A+L E ++  E E SE++ ++  L+ KL      K  L   
Sbjct: 208 ELYRNTITDEELKEKN---AKLQEKLQLVESEKSEIQLNVKELKRKL---ERAKLLLPQQ 261

Query: 332 SNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDE 391
               + + L K  Q V     A++E  +L  ++            +EEK + Q++KI + 
Sbjct: 262 QLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQ---------QQEEKMWRQEEKIQEW 312

Query: 392 NQKQLTFISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSANLER-ESQ 450
            +K    I ++E  + ++   I+  EE +   +E+    +   ++Q +++    E+   Q
Sbjct: 313 EEK----IQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQ 368

Query: 451 RCVITQWKMACLRKKHARWTAKIKA----EIQAITEKIQNAEVRRIE--LLNETSFRQQE 504
             ++ + +    R++   W  + K     E     EKI+  E +R E   + E   RQ++
Sbjct: 369 EEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQ 428

Query: 505 ISGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQ 564
            +    Q EK+    ++EEK    ++KM  +E   +E+  ++E +  ++++EE+     +
Sbjct: 429 EAKMWRQEEKIR---EQEEKIREQEKKMWRQEEKIHEQEKIREEE-KRQEQEEMWRQEEK 484

Query: 565 LQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQQL 624
           +   E+ +++K +  E+   I   ++QEE +                   E ++++ +++
Sbjct: 485 IHEQEEIWRQKEKMHEQEEKI---RKQEEKVWRQE---------------EKIREQEEKI 526

Query: 625 RDQESKKNKDHFETLKNLENGFYINDQKADLLLLENKKLKEYILYLKNNIEKYREGQEAL 684
           R+QE K  +   +  +  E             + E +K +E    +    EK RE +E +
Sbjct: 527 REQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKV 586

Query: 685 MHTSNDLSRQLIAQEAQYKDLWAEFQTTVKILVDNGEETLQDINNLTDKLRERDEKMQHV 744
                 +  Q   ++ Q + +W +                       +K+RE++EK+Q  
Sbjct: 587 WRQEEKIREQEEKRQEQEEKMWKQ----------------------EEKIREQEEKIQEQ 624

Query: 745 STWLRGSLEGLRLLVEQESPMDLLSKQQLRALLVTSKEEKTCQ 787
              +R   E +R   EQE   ++  +Q+ +   +  +EEK C+
Sbjct: 625 EEKIREQEEKIR---EQE---EMTQEQEEK---MGEQEEKMCE 658



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 58/311 (18%), Positives = 143/311 (45%), Gaps = 32/311 (10%)

Query: 118 EECVRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARF 177
           EE + +  ++   E    +  + R E +I     +  ++ +  E + E++E++ ++  + 
Sbjct: 457 EEKIHEQEKIREEEKRQEQEEMWRQEEKIH----EQEEIWRQKEKMHEQEEKIRKQEEKV 512

Query: 178 VLSLNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKERA--------- 228
                +  E++      I E   K+  + E I  Q++  +E E++ E+E+          
Sbjct: 513 WRQEEKIREQEEK----IREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQ 568

Query: 229 -EYLIRKQELTAQINEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHN 287
            + + R++E   +  E    +E K  E  +K++E ++   KM K +E +      + +  
Sbjct: 569 EDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEE---KMWKQEEKIREQEEKIQEQE 625

Query: 288 LEIARLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLV 347
            +I    E IR  E+   E ++ +   E K+C   + +EK+ +    ++     + +++ 
Sbjct: 626 EKIREQEEKIREQEEMTQEQEEKMGEQEEKMC---EQEEKMQE----QEETMWRQEEKIR 678

Query: 348 ETLHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLS 407
           E     R + + +RE+ + +  Q + +  +EEK   Q++K+ ++ +K    + ++E  + 
Sbjct: 679 EQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEK----MRRQEEKMW 734

Query: 408 QKRVDIKNMEE 418
           ++ V ++  EE
Sbjct: 735 EQEVRLRQQEE 745


>gi|156104908 myosin heavy chain 6 [Homo sapiens]
          Length = 1939

 Score = 93.6 bits (231), Expect = 7e-19
 Identities = 147/746 (19%), Positives = 322/746 (43%), Gaps = 87/746 (11%)

Query: 79   KKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEECVRDARRLNLFEINTIKMR 138
            K L+E  +  +D L++E  ++N L        +  K +LE+ V D    +L +   ++M 
Sbjct: 999  KALQEAHQQALDDLQVEEDKVNSL--------SKSKVKLEQQVDDLEG-SLEQEKKVRMD 1049

Query: 139  ITRT----ENEIELLKKKITDLTKYNEALGEKQEELARKHARFVLSLNQTMEKKATTTVY 194
            + R     E +++L ++ I DL   N+ L  + EE  +K    +   N  +E +    + 
Sbjct: 1050 LERAKRKLEGDLKLTQESIMDLE--NDKL--QLEEKLKKKEFDINQQNSKIEDEQVLALQ 1105

Query: 195  INETYTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVKRME 254
            + +   +   + E++  + +  + A   +EK R++     +E++ ++ E      V+   
Sbjct: 1106 LQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEM 1165

Query: 255  TYQKKKELDKLQTKMSKIK-ETVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAI 313
              +++ E  K++  + +   +    +AA+   H   +A L E I   ++   +L+K+ + 
Sbjct: 1166 NKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKS- 1224

Query: 314  LEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKI 373
                     + K +LDD++++            +E +  A+   + +   ++  A +Y++
Sbjct: 1225 ---------EFKLELDDVTSN------------MEQIIKAKANLEKVSRTLEDQANEYRV 1263

Query: 374  VLSEEEKAF----LQKQKIHDENQKQLTFISQKEYFLSQ----KRVDIKNMEEGLITLQE 425
             L E +++      Q+ K+  EN +    + +KE  +SQ    K    + ME+    L+E
Sbjct: 1264 KLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEE 1323

Query: 426  LQQATKTVY------QQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQA 479
              +A   +       +    +L    E E++     Q  ++    + A+W  K + +   
Sbjct: 1324 EGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQ 1383

Query: 480  ITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEE-EKAFVNKEKM------ 532
             TE+++ A+ +  + L +     + ++   + +EK    L+ E E   V+ E+       
Sbjct: 1384 RTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAA 1443

Query: 533  LMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQE-YKEKRRKLEELSNIITAQRQ 591
            L K+   +++I  +  Q  +E + EL     + +    E +K K    E L ++ T +R+
Sbjct: 1444 LDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRE 1503

Query: 592  EEDLLNNHIFLFTR--DFSRYISNMEDVKQELQ------QLRDQESKKNKDHFETLKNLE 643
             ++L      L  +  +  + +  +E V+++L+      Q   +E++ + +H E  K L 
Sbjct: 1504 NKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEG-KILR 1562

Query: 644  NGFYINDQKADLLLLENKKLKEYILYLKNN---IEKYREGQEALMHTSNDLSR------- 693
                 N  KA++     +K +E     +N+   ++  +   +A   + N++ R       
Sbjct: 1563 AQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEG 1622

Query: 694  ---QLIAQEAQYKDLWAEFQTTVKILVDNGEET---LQDINNLTDKLRERDEKMQHVSTW 747
               ++  Q +    + AE Q  VK L    ++T   L D     D L+E    ++  +  
Sbjct: 1623 DLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNL 1682

Query: 748  LRGSLEGLRLLVEQESPMDLLSKQQL 773
            L+  LE LR +VEQ      L++Q+L
Sbjct: 1683 LQAELEELRAVVEQTERSRKLAEQEL 1708



 Score = 67.8 bits (164), Expect = 4e-11
 Identities = 160/845 (18%), Positives = 327/845 (38%), Gaps = 172/845 (20%)

Query: 52   VEQSLQSDYFKCNEEAKIFLKDIAVAV---KKLEEMRKATIDLLEIESMELNKLYYLLET 108
            +E+ L+   F  N++      +  +A+   KKL+E  +A I+ LE E          +E 
Sbjct: 1078 LEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKE-NQARIEELEEELEAERTARAKVEK 1136

Query: 109  LPNSIKRELEEC---VRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEALGE 165
            L + + RELEE    + +A      +I   K R    E E + +++ + + T  +EA   
Sbjct: 1137 LRSDLSRELEEISERLEEAGGATSVQIEMNKKR----EAEFQKMRRDLEEATLQHEATAA 1192

Query: 166  KQEELARKHARFVLSLNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEK 225
                L +KHA  V  L + ++        + +  ++  L+ +D+    + I +A+  +EK
Sbjct: 1193 A---LRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEK 1249

Query: 226  -------ERAEYLIRKQELTAQINEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTV 278
                   +  EY ++ +E    +N+F   R   + E  +  ++L++ +  +S++      
Sbjct: 1250 VSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLS 1309

Query: 279  SAAVLSD----------------HNLEIARLH-ESIRYWEQEVSELKKDLA--------- 312
                + D                H L+ AR   + +R   +E +E K +L          
Sbjct: 1310 YTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSE 1369

Query: 313  ILEAKLCFFTDNKEKLDDISNDEKN------------EFLN-KIKQLVETLHAARMEYKD 359
            + + +  + TD  ++ +++   +K             E +N K   L +T H  + E +D
Sbjct: 1370 VAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIED 1429

Query: 360  LR---EKMKTLA-------RQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQK 409
            L    E+    A       R +  +L+E ++ + + Q   + +QK+   +S + + L   
Sbjct: 1430 LMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNA 1489

Query: 410  -----------RVDIKNMEEGLITLQE-----------------------------LQQA 429
                       + + KN++E +  L E                             L++A
Sbjct: 1490 YEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEA 1549

Query: 430  TKTVYQQQIKILSANLERESQRCVITQW------KMACLRKKHARWTAKIKAEIQAITEK 483
              ++  ++ KIL A LE    +  I +       +M   ++ H R    ++  + A T  
Sbjct: 1550 EASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRS 1609

Query: 484  IQNAEVRRIEL-----LNETSFRQQEISGFVAQIEK---------------------LTT 517
                EV R++      LNE   +    +   A+ +K                        
Sbjct: 1610 --RNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRAND 1667

Query: 518  ELKEEEKAFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRR 577
            +LKE       +  +L  EL +   +  +  +  K  E+EL+E   ++Q+   +      
Sbjct: 1668 DLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLIN 1727

Query: 578  KLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQQLRD-----QESKKN 632
            + +++ + +T  + E +              + I++   + +EL++ +D     +  KKN
Sbjct: 1728 QKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKN 1787

Query: 633  KDHFETLKNLENGFYINDQKADLLLLENK----KLKEYILYLKNNIE-KYREGQEAL--M 685
             +  +T+K+L++     D+   + L   K    KL+  +  L+  +E + +   E++  M
Sbjct: 1788 ME--QTIKDLQHRL---DEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGM 1842

Query: 686  HTSNDLSRQLIAQEAQYK-------DLWAEFQTTVKILVDNGEETLQDINNLTDKLRERD 738
              S    ++L  Q  + K       DL  + Q  VK      EE  +  N    K R   
Sbjct: 1843 RKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFR--- 1899

Query: 739  EKMQH 743
             K+QH
Sbjct: 1900 -KVQH 1903



 Score = 66.6 bits (161), Expect = 9e-11
 Identities = 119/561 (21%), Positives = 230/561 (40%), Gaps = 72/561 (12%)

Query: 197  ETYTKINLKREDIALQKKCIQEAE---ELMEKERAEYLIRKQELTAQINEFENTREVKRM 253
            ET  ++   +E+    K+ ++++E   + +E++    L  K +L  Q+   ++       
Sbjct: 846  ETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEE 905

Query: 254  ETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAI 313
               Q  K   +L+ K+ ++ E        L D     A L    R  E E SELKKD+  
Sbjct: 906  RCDQLIKNKIQLEAKVKEMNER-------LEDEEEMNAELTAKKRKLEDECSELKKDIDD 958

Query: 314  LEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKI 373
            LE  L       EK       EK+   NK+K L E       E   L E +  L ++ K 
Sbjct: 959  LELTLA----KVEK-------EKHATENKVKNLTE-------EMAGLDEIIAKLTKEKKA 1000

Query: 374  VLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTV 433
            +           Q+ H +    L     K   LS+ +V ++   + L    E ++  +  
Sbjct: 1001 L-----------QEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMD 1049

Query: 434  YQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKA---EIQAITEKIQNAEVR 490
             ++  + L  +L+       +TQ  +  L     +   K+K    +I     KI++ +V 
Sbjct: 1050 LERAKRKLEGDLK-------LTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVL 1102

Query: 491  RIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKM---LMKELSKYEEIFVK- 546
             ++L       Q+++    A+IE+L  EL+ E  A    EK+   L +EL +  E   + 
Sbjct: 1103 ALQL-------QKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEA 1155

Query: 547  ------ETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEE-DLLNNH 599
                  + ++NK++E E  +    L+ A  +++     L +      A+  E+ D L   
Sbjct: 1156 GGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRV 1215

Query: 600  IFLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNLENGFYINDQKADLLLLE 659
                 ++ S +   ++DV   ++Q+   ++   K    TL++  N + +  ++A   L +
Sbjct: 1216 KQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVS-RTLEDQANEYRVKLEEAQRSLND 1274

Query: 660  NKKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTTVKILVDN 719
                +  +      + +  E +EAL+   + L+R  ++   Q +DL  + +   K   + 
Sbjct: 1275 FTTQRAKLQTENGELARQLEEKEALI---SQLTRGKLSYTQQMEDLKRQLEEEGK-AKNA 1330

Query: 720  GEETLQDINNLTDKLRERDEK 740
                LQ   +  D LRE+ E+
Sbjct: 1331 LAHALQSARHDCDLLREQYEE 1351



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 105/423 (24%), Positives = 182/423 (43%), Gaps = 57/423 (13%)

Query: 391  ENQKQLTFISQKEYF------LSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSAN 444
            E +K++   + KE F      L +     K +EE +++L  LQ+  K   Q Q++    N
Sbjct: 846  ETEKEMA--TMKEEFGRIKETLEKSEARRKELEEKMVSL--LQE--KNDLQLQVQAEQDN 899

Query: 445  LERESQRCVITQWKMACLRKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQE 504
            L    +RC         ++ K      +++A+++ + E++++ E    EL  +    + E
Sbjct: 900  LNDAEERCD------QLIKNK-----IQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDE 948

Query: 505  ISGFVAQIEKLTTELKEEEK---AFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEY 561
             S     I+ L   L + EK   A  NK K L +E++  +EI  K T+  K  +E   + 
Sbjct: 949  CSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQA 1008

Query: 562  LPQLQVAEQE---YKEKRRKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNME-DV 617
            L  LQV E +     + + KLE+  + +    ++E  +         D  R    +E D+
Sbjct: 1009 LDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVR-------MDLERAKRKLEGDL 1061

Query: 618  KQELQQLRDQESKKNKDHFETLKNLENGFYINDQKAD------LLLLENKKLKE---YIL 668
            K   + + D E+ K +   E LK  E  F IN Q +       L L   KKLKE    I 
Sbjct: 1062 KLTQESIMDLENDKLQLE-EKLKKKE--FDINQQNSKIEDEQVLALQLQKKLKENQARIE 1118

Query: 669  YLKNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTTVKILVDNGEETLQDIN 728
             L+  +E  R  +  +    +DLSR+L  +E   +   A   T+V+I ++   E   +  
Sbjct: 1119 ELEEELEAERTARAKVEKLRSDLSREL--EEISERLEEAGGATSVQIEMNKKREA--EFQ 1174

Query: 729  NLTDKLRERDEKMQHVSTWLRGSLEGLRLLVEQESPMDLLSKQQLRALLVTSKEEKTCQL 788
             +   L E    +QH +T      +    + E    +D L  Q+++  L   K E   +L
Sbjct: 1175 KMRRDLEE--ATLQHEATAAALRKKHADSVAELGEQIDNL--QRVKQKLEKEKSEFKLEL 1230

Query: 789  SDL 791
             D+
Sbjct: 1231 DDV 1233


>gi|33946313 ninein isoform 4 [Homo sapiens]
          Length = 2096

 Score = 93.6 bits (231), Expect = 7e-19
 Identities = 166/744 (22%), Positives = 322/744 (43%), Gaps = 123/744 (16%)

Query: 140  TRTE-----NEIELLKKKITDLTKYNEALGEKQEELARKHARFVLSLNQTMEKKATTTVY 194
            TRTE     N+I  L++++  L    +   EK+++L      F +S+   ++KK      
Sbjct: 1195 TRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLL-----FDVSV---LKKKLKMLER 1246

Query: 195  INETYTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVKRME 254
            I E   K  L  ED++ +  C+QE   +ME    E L   +ELTA++  F    E+K+ME
Sbjct: 1247 IPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEV--FRLQDELKKME 1304

Query: 255  TYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAIL 314
                  E+ +    + K  + V +    L   N+ + RL   I   ++ V + + D  + 
Sbjct: 1305 ------EVTETFLSLEKSYDEVKIENEEL---NVLVLRLQGKIEKLQESVVQ-RCDCCLW 1354

Query: 315  EAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYK----------DLREKM 364
            EA L    +N E   D +  + N+ L +    V ++H    E K           L EK+
Sbjct: 1355 EASL----ENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKV 1410

Query: 365  KT--LARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLIT 422
            K   +A  +  + + +E+  +Q Q I +EN   L F  Q ++F  Q +  I  +E     
Sbjct: 1411 KAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGF--QDKHF--QHQATIAELELEKTK 1466

Query: 423  LQELQQATK---TVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKAE-IQ 478
            LQEL +  K   T+  +Q  +LS   + E  + ++   ++ C   +      + ++E +Q
Sbjct: 1467 LQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQ 1526

Query: 479  AITEKIQNAEVRRIELLNE----TSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLM 534
                 ++N     I  LNE    ++ +   ++G   ++ + T  +K+E  A     + L 
Sbjct: 1527 QENSILRN----EITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLK 1582

Query: 535  KELS----KYEEIFVKETQI------NKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSN 584
            K++S    K +++ ++ T++      N+EK +EL + L ++ + ++E +     LEE   
Sbjct: 1583 KQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEM-LCQKEKEPGNSALEE--- 1638

Query: 585  IITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQ---QLRDQESKKNKDHFETLKN 641
                + QE+  L   +       S  +S++E    E++    +  QE+   KD  E +K 
Sbjct: 1639 ----REQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQ 1694

Query: 642  LENGFYIND--QKADLLLLENKKL---KEYI--------------LYLKNNIEKYREGQE 682
            L     ++D  QK   +L  N+KL   KE +                L++ I   ++ Q+
Sbjct: 1695 LHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQK 1754

Query: 683  ALMHTSNDLSRQLIAQEAQYKDL----------WAEFQTTVKILVDNGEETLQDINNLTD 732
            +  H S  L  QL+A + + ++L           +  ++ +++     E   Q++ +L  
Sbjct: 1755 SWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHK 1814

Query: 733  KLRERDEK--MQHVSTWLRG--------SLEGLRLLVEQESPMDLLSKQQLRALL----- 777
            +L+    K     ++T   G        S + L  L+ +E  +     ++L+ ++     
Sbjct: 1815 QLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKA 1874

Query: 778  -VTSKEEKTCQLSDLVIPNYATNI 800
             +T   EK  QL   ++P +  ++
Sbjct: 1875 ELTHSREKVRQLESNLLPKHQKHL 1898



 Score = 80.1 bits (196), Expect = 8e-15
 Identities = 155/757 (20%), Positives = 315/757 (41%), Gaps = 120/757 (15%)

Query: 66   EAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPNSI--KRELEECVRD 123
            +  I L ++ +A++    + K +I    + S +  ++ +LLE +   +  K +L   +  
Sbjct: 340  DGNINLTELTLALENELLVTKNSIHQAALASFKA-EIRHLLERVDQVVREKEKLRSDLDK 398

Query: 124  ARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFV----- 178
            A +L     + +       E   E   +K+ +  +Y E +   + EL ++  + +     
Sbjct: 399  AEKLKSLMASEVDDHHAAIERRNEYNLRKLDE--EYKERIAALKNELRKEREQILQQAGK 456

Query: 179  --LSLNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKER--------- 227
              L L Q +EK  T   YI +    ++LK E+  L+ + ++ AE+L E E          
Sbjct: 457  QRLELEQEIEKAKTEENYIRDRLA-LSLK-ENSRLENELLENAEKLAEYENLTNKLQRNL 514

Query: 228  ---------------AEYLIRKQELTAQINEFENTREV---------KRMETYQKKKELD 263
                           AE+ ++++ LT   NE+E    V           +E Y+ +  + 
Sbjct: 515  ENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVL 574

Query: 264  KLQTKMSKIKETVTVSAAVLSDHNL---EIARLHESIR---YWEQEVSELKKDLAILEAK 317
            +L  K S  +E    S  +  +H L   E   L+ SI      EQ   +  +D+  L  +
Sbjct: 575  RLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLE 634

Query: 318  LCFFTDNKEK-LDDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLS 376
            L     + EK LD+     K    N  ++     H    +  DL+ ++  L  Q  ++  
Sbjct: 635  LEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKE 694

Query: 377  ---------EEEKAFLQ----KQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLIT- 422
                     EEEK  LQ    ++K H + + +L    + +  L+Q +   +   EGL + 
Sbjct: 695  AHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSS 754

Query: 423  ------LQELQQATKTVYQQQIKIL--SANLERESQRCVITQWKMACLRKKHA------- 467
                  ++ L Q  +  +Q+Q+  L     LE+E  R  + +     L++          
Sbjct: 755  AWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECN 814

Query: 468  RWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFV 527
            R T++I+A+ Q+  +K+       ++ L E  +RQ        +++ L  + +EE+  + 
Sbjct: 815  RRTSQIEAQFQSDCQKVTERCESALQSL-EGRYRQ--------ELKDLQEQQREEKSQWE 865

Query: 528  NKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYK--------EKRRKL 579
             ++  L +E ++ +E+ +KET + +EK   LV    + ++ E+ YK        E+++ L
Sbjct: 866  FEKDELTQECAEAQEL-LKET-LKREKTTSLV-LTQEREMLEKTYKEHLNSMVVERQQLL 922

Query: 580  EELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDV-----------KQELQQLRDQE 628
            ++L ++      ++ LL++ I        R +   E+V            Q L++L  + 
Sbjct: 923  QDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEH 982

Query: 629  SKKNKDHFETLKNLENGFYINDQKADLLLLENKKLKEYILYLKNNIEKYREGQEALMHTS 688
             ++ ++    L  +EN      + AD    E  ++   I  L++ I++ ++    L    
Sbjct: 983  DQERQEMMSKLLAMENIHKATCETAD---RERAEMSTEISRLQSKIKEMQQATSPLSMLQ 1039

Query: 689  NDLSRQLIAQEAQYKD-LWAEFQTTVKILVDNGEETL 724
            +    Q+I +E    D   +  Q   ++L +NG+  L
Sbjct: 1040 SGC--QVIGEEEVEGDGALSLLQQGEQLLEENGDVLL 1074



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 78/416 (18%), Positives = 186/416 (44%), Gaps = 43/416 (10%)

Query: 65   EEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRE-----LEE 119
            EE K  + D+ +   ++++     ++LL  ES +L +   +L     ++  E     L+ 
Sbjct: 1495 EELKAMMHDLQITCSEMQQK----VELLRYESEKLQQENSILRNEITTLNEEDSISNLKL 1550

Query: 120  CVRDARRLNLFE-INTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHAR-- 176
               +  +  +++   T+K      +  +E LKK+I++L   N+ L  +  EL++K+++  
Sbjct: 1551 GTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQ 1610

Query: 177  -FVLSLNQTM-------EKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKERA 228
              +  LNQ +       EK+   +        K NLK E     ++C  ++  L+    A
Sbjct: 1611 EKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEE----LERCKVQSSTLVSSLEA 1666

Query: 229  EYLIRKQELTAQINEFEN---TREVKRMETYQKKKELDKLQTKMSKI----------KET 275
            E  + + ++   I + EN     E+++M+   +  +L   Q K+S +          KE 
Sbjct: 1667 E--LSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEA 1724

Query: 276  VTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDE 335
            ++       D   + + L   I   +QE    +   A L+++L     ++EK+ ++ +  
Sbjct: 1725 LSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQL---VASQEKVQNLEDTV 1781

Query: 336  KNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQ 395
            +N  L ++ ++   L   + E + L++++ +L +Q +    +     +        NQ++
Sbjct: 1782 QNVNL-QMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQK 1840

Query: 396  LTFISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSANLERESQR 451
                 + ++ +++++  +    E L T+ +  +A  T  +++++ L +NL  + Q+
Sbjct: 1841 RLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQK 1896



 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 134/658 (20%), Positives = 264/658 (40%), Gaps = 109/658 (16%)

Query: 202 INLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVKRMETYQKKKE 261
           INL    +AL+ + +     + +   A +    + L  +++              Q  +E
Sbjct: 343 INLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVD--------------QVVRE 388

Query: 262 LDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHE-SIRYWEQEVSE----LKKDLAILEA 316
            +KL++ + K ++  ++ A+ + DH+  I R +E ++R  ++E  E    LK +L   E 
Sbjct: 389 KEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELR-KER 447

Query: 317 KLCFFTDNKEKLD-------------------DISNDEKNEFLNKIKQLVETLHAARMEY 357
           +       K++L+                    +S  E +   N++ +  E L     EY
Sbjct: 448 EQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKL----AEY 503

Query: 358 KDLREKMK-----TLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVD 412
           ++L  K++      LA ++  +     + FLQ++++      Q+    +++  + Q +VD
Sbjct: 504 ENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERL-----TQMRNEYERQCRVLQDQVD 558

Query: 413 --IKNMEEGLITLQELQQATKTVYQQQIKILSANLERE----SQRC-----------VIT 455
                +EE     + L+   K    ++++  S  +E E    S+ C           VI 
Sbjct: 559 ELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIE 618

Query: 456 QWK------MACLR---KKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEIS 506
           Q K      + CLR   +   R   K   E     +K Q    +R E  NET   +++IS
Sbjct: 619 QMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHE--NETHTLEKQIS 676

Query: 507 GF---VAQIEKLTTELKE--EEKAFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEY 561
                +A+++     LKE   E    ++E+    ++   EE    + ++  + E EL   
Sbjct: 677 DLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKAR 736

Query: 562 LPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQEL 621
           L Q Q + +  +E  +        +    QE  L   H    T    ++    E++++EL
Sbjct: 737 LTQAQASFEREREGLQSSAWTEEKVRGLTQE--LEQFHQEQLTSLVEKHTLEKEELRKEL 794

Query: 622 QQLRDQESKKNKDHFETLKN-----LENGFYINDQK------ADLLLLENKKLKEYILYL 670
            +   +E ++ ++  ET  N     +E  F  + QK      + L  LE +  +E    L
Sbjct: 795 LEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQE----L 850

Query: 671 KNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTTVKILVDNGEETLQDI-NN 729
           K+  E+ RE +       ++L+++    +   K+     +TT  +L    E   +    +
Sbjct: 851 KDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEH 910

Query: 730 LTDKLRERDEKMQHVSTWLRGSLEGLRLLVEQESPMDLLSKQQLRALLVTSKEEKTCQ 787
           L   + ER + +Q +      S     LL +Q   +    K++LR      +EE  CQ
Sbjct: 911 LNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELR-----EREEVLCQ 963


>gi|33946321 ninein isoform 5 [Homo sapiens]
          Length = 2090

 Score = 93.6 bits (231), Expect = 7e-19
 Identities = 166/744 (22%), Positives = 322/744 (43%), Gaps = 123/744 (16%)

Query: 140  TRTE-----NEIELLKKKITDLTKYNEALGEKQEELARKHARFVLSLNQTMEKKATTTVY 194
            TRTE     N+I  L++++  L    +   EK+++L      F +S+   ++KK      
Sbjct: 1189 TRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLL-----FDVSV---LKKKLKMLER 1240

Query: 195  INETYTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVKRME 254
            I E   K  L  ED++ +  C+QE   +ME    E L   +ELTA++  F    E+K+ME
Sbjct: 1241 IPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEV--FRLQDELKKME 1298

Query: 255  TYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAIL 314
                  E+ +    + K  + V +    L   N+ + RL   I   ++ V + + D  + 
Sbjct: 1299 ------EVTETFLSLEKSYDEVKIENEEL---NVLVLRLQGKIEKLQESVVQ-RCDCCLW 1348

Query: 315  EAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYK----------DLREKM 364
            EA L    +N E   D +  + N+ L +    V ++H    E K           L EK+
Sbjct: 1349 EASL----ENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKV 1404

Query: 365  KT--LARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLIT 422
            K   +A  +  + + +E+  +Q Q I +EN   L F  Q ++F  Q +  I  +E     
Sbjct: 1405 KAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGF--QDKHF--QHQATIAELELEKTK 1460

Query: 423  LQELQQATK---TVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKAE-IQ 478
            LQEL +  K   T+  +Q  +LS   + E  + ++   ++ C   +      + ++E +Q
Sbjct: 1461 LQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQ 1520

Query: 479  AITEKIQNAEVRRIELLNE----TSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLM 534
                 ++N     I  LNE    ++ +   ++G   ++ + T  +K+E  A     + L 
Sbjct: 1521 QENSILRN----EITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLK 1576

Query: 535  KELS----KYEEIFVKETQI------NKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSN 584
            K++S    K +++ ++ T++      N+EK +EL + L ++ + ++E +     LEE   
Sbjct: 1577 KQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEM-LCQKEKEPGNSALEE--- 1632

Query: 585  IITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQ---QLRDQESKKNKDHFETLKN 641
                + QE+  L   +       S  +S++E    E++    +  QE+   KD  E +K 
Sbjct: 1633 ----REQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQ 1688

Query: 642  LENGFYIND--QKADLLLLENKKL---KEYI--------------LYLKNNIEKYREGQE 682
            L     ++D  QK   +L  N+KL   KE +                L++ I   ++ Q+
Sbjct: 1689 LHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQK 1748

Query: 683  ALMHTSNDLSRQLIAQEAQYKDL----------WAEFQTTVKILVDNGEETLQDINNLTD 732
            +  H S  L  QL+A + + ++L           +  ++ +++     E   Q++ +L  
Sbjct: 1749 SWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHK 1808

Query: 733  KLRERDEK--MQHVSTWLRG--------SLEGLRLLVEQESPMDLLSKQQLRALL----- 777
            +L+    K     ++T   G        S + L  L+ +E  +     ++L+ ++     
Sbjct: 1809 QLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKA 1868

Query: 778  -VTSKEEKTCQLSDLVIPNYATNI 800
             +T   EK  QL   ++P +  ++
Sbjct: 1869 ELTHSREKVRQLESNLLPKHQKHL 1892



 Score = 80.1 bits (196), Expect = 8e-15
 Identities = 155/757 (20%), Positives = 315/757 (41%), Gaps = 120/757 (15%)

Query: 66   EAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPNSI--KRELEECVRD 123
            +  I L ++ +A++    + K +I    + S +  ++ +LLE +   +  K +L   +  
Sbjct: 334  DGNINLTELTLALENELLVTKNSIHQAALASFKA-EIRHLLERVDQVVREKEKLRSDLDK 392

Query: 124  ARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFV----- 178
            A +L     + +       E   E   +K+ +  +Y E +   + EL ++  + +     
Sbjct: 393  AEKLKSLMASEVDDHHAAIERRNEYNLRKLDE--EYKERIAALKNELRKEREQILQQAGK 450

Query: 179  --LSLNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKER--------- 227
              L L Q +EK  T   YI +    ++LK E+  L+ + ++ AE+L E E          
Sbjct: 451  QRLELEQEIEKAKTEENYIRDRLA-LSLK-ENSRLENELLENAEKLAEYENLTNKLQRNL 508

Query: 228  ---------------AEYLIRKQELTAQINEFENTREV---------KRMETYQKKKELD 263
                           AE+ ++++ LT   NE+E    V           +E Y+ +  + 
Sbjct: 509  ENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVL 568

Query: 264  KLQTKMSKIKETVTVSAAVLSDHNL---EIARLHESIR---YWEQEVSELKKDLAILEAK 317
            +L  K S  +E    S  +  +H L   E   L+ SI      EQ   +  +D+  L  +
Sbjct: 569  RLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLE 628

Query: 318  LCFFTDNKEK-LDDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLS 376
            L     + EK LD+     K    N  ++     H    +  DL+ ++  L  Q  ++  
Sbjct: 629  LEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKE 688

Query: 377  ---------EEEKAFLQ----KQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLIT- 422
                     EEEK  LQ    ++K H + + +L    + +  L+Q +   +   EGL + 
Sbjct: 689  AHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSS 748

Query: 423  ------LQELQQATKTVYQQQIKIL--SANLERESQRCVITQWKMACLRKKHA------- 467
                  ++ L Q  +  +Q+Q+  L     LE+E  R  + +     L++          
Sbjct: 749  AWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECN 808

Query: 468  RWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFV 527
            R T++I+A+ Q+  +K+       ++ L E  +RQ        +++ L  + +EE+  + 
Sbjct: 809  RRTSQIEAQFQSDCQKVTERCESALQSL-EGRYRQ--------ELKDLQEQQREEKSQWE 859

Query: 528  NKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYK--------EKRRKL 579
             ++  L +E ++ +E+ +KET + +EK   LV    + ++ E+ YK        E+++ L
Sbjct: 860  FEKDELTQECAEAQEL-LKET-LKREKTTSLV-LTQEREMLEKTYKEHLNSMVVERQQLL 916

Query: 580  EELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDV-----------KQELQQLRDQE 628
            ++L ++      ++ LL++ I        R +   E+V            Q L++L  + 
Sbjct: 917  QDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEH 976

Query: 629  SKKNKDHFETLKNLENGFYINDQKADLLLLENKKLKEYILYLKNNIEKYREGQEALMHTS 688
             ++ ++    L  +EN      + AD    E  ++   I  L++ I++ ++    L    
Sbjct: 977  DQERQEMMSKLLAMENIHKATCETAD---RERAEMSTEISRLQSKIKEMQQATSPLSMLQ 1033

Query: 689  NDLSRQLIAQEAQYKD-LWAEFQTTVKILVDNGEETL 724
            +    Q+I +E    D   +  Q   ++L +NG+  L
Sbjct: 1034 SGC--QVIGEEEVEGDGALSLLQQGEQLLEENGDVLL 1068



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 78/416 (18%), Positives = 186/416 (44%), Gaps = 43/416 (10%)

Query: 65   EEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRE-----LEE 119
            EE K  + D+ +   ++++     ++LL  ES +L +   +L     ++  E     L+ 
Sbjct: 1489 EELKAMMHDLQITCSEMQQK----VELLRYESEKLQQENSILRNEITTLNEEDSISNLKL 1544

Query: 120  CVRDARRLNLFE-INTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHAR-- 176
               +  +  +++   T+K      +  +E LKK+I++L   N+ L  +  EL++K+++  
Sbjct: 1545 GTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQ 1604

Query: 177  -FVLSLNQTM-------EKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKERA 228
              +  LNQ +       EK+   +        K NLK E     ++C  ++  L+    A
Sbjct: 1605 EKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEE----LERCKVQSSTLVSSLEA 1660

Query: 229  EYLIRKQELTAQINEFEN---TREVKRMETYQKKKELDKLQTKMSKI----------KET 275
            E  + + ++   I + EN     E+++M+   +  +L   Q K+S +          KE 
Sbjct: 1661 E--LSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEA 1718

Query: 276  VTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDE 335
            ++       D   + + L   I   +QE    +   A L+++L     ++EK+ ++ +  
Sbjct: 1719 LSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQL---VASQEKVQNLEDTV 1775

Query: 336  KNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQ 395
            +N  L ++ ++   L   + E + L++++ +L +Q +    +     +        NQ++
Sbjct: 1776 QNVNL-QMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQK 1834

Query: 396  LTFISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSANLERESQR 451
                 + ++ +++++  +    E L T+ +  +A  T  +++++ L +NL  + Q+
Sbjct: 1835 RLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQK 1890



 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 134/658 (20%), Positives = 264/658 (40%), Gaps = 109/658 (16%)

Query: 202 INLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVKRMETYQKKKE 261
           INL    +AL+ + +     + +   A +    + L  +++              Q  +E
Sbjct: 337 INLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVD--------------QVVRE 382

Query: 262 LDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHE-SIRYWEQEVSE----LKKDLAILEA 316
            +KL++ + K ++  ++ A+ + DH+  I R +E ++R  ++E  E    LK +L   E 
Sbjct: 383 KEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELR-KER 441

Query: 317 KLCFFTDNKEKLD-------------------DISNDEKNEFLNKIKQLVETLHAARMEY 357
           +       K++L+                    +S  E +   N++ +  E L     EY
Sbjct: 442 EQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKL----AEY 497

Query: 358 KDLREKMK-----TLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVD 412
           ++L  K++      LA ++  +     + FLQ++++      Q+    +++  + Q +VD
Sbjct: 498 ENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERL-----TQMRNEYERQCRVLQDQVD 552

Query: 413 --IKNMEEGLITLQELQQATKTVYQQQIKILSANLERE----SQRC-----------VIT 455
                +EE     + L+   K    ++++  S  +E E    S+ C           VI 
Sbjct: 553 ELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIE 612

Query: 456 QWK------MACLR---KKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEIS 506
           Q K      + CLR   +   R   K   E     +K Q    +R E  NET   +++IS
Sbjct: 613 QMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHE--NETHTLEKQIS 670

Query: 507 GF---VAQIEKLTTELKE--EEKAFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEY 561
                +A+++     LKE   E    ++E+    ++   EE    + ++  + E EL   
Sbjct: 671 DLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKAR 730

Query: 562 LPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQEL 621
           L Q Q + +  +E  +        +    QE  L   H    T    ++    E++++EL
Sbjct: 731 LTQAQASFEREREGLQSSAWTEEKVRGLTQE--LEQFHQEQLTSLVEKHTLEKEELRKEL 788

Query: 622 QQLRDQESKKNKDHFETLKN-----LENGFYINDQK------ADLLLLENKKLKEYILYL 670
            +   +E ++ ++  ET  N     +E  F  + QK      + L  LE +  +E    L
Sbjct: 789 LEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQE----L 844

Query: 671 KNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTTVKILVDNGEETLQDI-NN 729
           K+  E+ RE +       ++L+++    +   K+     +TT  +L    E   +    +
Sbjct: 845 KDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEH 904

Query: 730 LTDKLRERDEKMQHVSTWLRGSLEGLRLLVEQESPMDLLSKQQLRALLVTSKEEKTCQ 787
           L   + ER + +Q +      S     LL +Q   +    K++LR      +EE  CQ
Sbjct: 905 LNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELR-----EREEVLCQ 957


>gi|148536871 ninein isoform 1 [Homo sapiens]
          Length = 2046

 Score = 93.6 bits (231), Expect = 7e-19
 Identities = 166/744 (22%), Positives = 322/744 (43%), Gaps = 123/744 (16%)

Query: 140  TRTE-----NEIELLKKKITDLTKYNEALGEKQEELARKHARFVLSLNQTMEKKATTTVY 194
            TRTE     N+I  L++++  L    +   EK+++L      F +S+   ++KK      
Sbjct: 1189 TRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLL-----FDVSV---LKKKLKMLER 1240

Query: 195  INETYTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVKRME 254
            I E   K  L  ED++ +  C+QE   +ME    E L   +ELTA++  F    E+K+ME
Sbjct: 1241 IPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEV--FRLQDELKKME 1298

Query: 255  TYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAIL 314
                  E+ +    + K  + V +    L   N+ + RL   I   ++ V + + D  + 
Sbjct: 1299 ------EVTETFLSLEKSYDEVKIENEEL---NVLVLRLQGKIEKLQESVVQ-RCDCCLW 1348

Query: 315  EAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYK----------DLREKM 364
            EA L    +N E   D +  + N+ L +    V ++H    E K           L EK+
Sbjct: 1349 EASL----ENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKV 1404

Query: 365  KT--LARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLIT 422
            K   +A  +  + + +E+  +Q Q I +EN   L F  Q ++F  Q +  I  +E     
Sbjct: 1405 KAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGF--QDKHF--QHQATIAELELEKTK 1460

Query: 423  LQELQQATK---TVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKAE-IQ 478
            LQEL +  K   T+  +Q  +LS   + E  + ++   ++ C   +      + ++E +Q
Sbjct: 1461 LQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQ 1520

Query: 479  AITEKIQNAEVRRIELLNE----TSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLM 534
                 ++N     I  LNE    ++ +   ++G   ++ + T  +K+E  A     + L 
Sbjct: 1521 QENSILRN----EITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLK 1576

Query: 535  KELS----KYEEIFVKETQI------NKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSN 584
            K++S    K +++ ++ T++      N+EK +EL + L ++ + ++E +     LEE   
Sbjct: 1577 KQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEM-LCQKEKEPGNSALEE--- 1632

Query: 585  IITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQ---QLRDQESKKNKDHFETLKN 641
                + QE+  L   +       S  +S++E    E++    +  QE+   KD  E +K 
Sbjct: 1633 ----REQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQ 1688

Query: 642  LENGFYIND--QKADLLLLENKKL---KEYI--------------LYLKNNIEKYREGQE 682
            L     ++D  QK   +L  N+KL   KE +                L++ I   ++ Q+
Sbjct: 1689 LHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQK 1748

Query: 683  ALMHTSNDLSRQLIAQEAQYKDL----------WAEFQTTVKILVDNGEETLQDINNLTD 732
            +  H S  L  QL+A + + ++L           +  ++ +++     E   Q++ +L  
Sbjct: 1749 SWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHK 1808

Query: 733  KLRERDEK--MQHVSTWLRG--------SLEGLRLLVEQESPMDLLSKQQLRALL----- 777
            +L+    K     ++T   G        S + L  L+ +E  +     ++L+ ++     
Sbjct: 1809 QLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKA 1868

Query: 778  -VTSKEEKTCQLSDLVIPNYATNI 800
             +T   EK  QL   ++P +  ++
Sbjct: 1869 ELTHSREKVRQLESNLLPKHQKHL 1892



 Score = 80.1 bits (196), Expect = 8e-15
 Identities = 155/757 (20%), Positives = 315/757 (41%), Gaps = 120/757 (15%)

Query: 66   EAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPNSI--KRELEECVRD 123
            +  I L ++ +A++    + K +I    + S +  ++ +LLE +   +  K +L   +  
Sbjct: 334  DGNINLTELTLALENELLVTKNSIHQAALASFKA-EIRHLLERVDQVVREKEKLRSDLDK 392

Query: 124  ARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFV----- 178
            A +L     + +       E   E   +K+ +  +Y E +   + EL ++  + +     
Sbjct: 393  AEKLKSLMASEVDDHHAAIERRNEYNLRKLDE--EYKERIAALKNELRKEREQILQQAGK 450

Query: 179  --LSLNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKER--------- 227
              L L Q +EK  T   YI +    ++LK E+  L+ + ++ AE+L E E          
Sbjct: 451  QRLELEQEIEKAKTEENYIRDRLA-LSLK-ENSRLENELLENAEKLAEYENLTNKLQRNL 508

Query: 228  ---------------AEYLIRKQELTAQINEFENTREV---------KRMETYQKKKELD 263
                           AE+ ++++ LT   NE+E    V           +E Y+ +  + 
Sbjct: 509  ENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVL 568

Query: 264  KLQTKMSKIKETVTVSAAVLSDHNL---EIARLHESIR---YWEQEVSELKKDLAILEAK 317
            +L  K S  +E    S  +  +H L   E   L+ SI      EQ   +  +D+  L  +
Sbjct: 569  RLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLE 628

Query: 318  LCFFTDNKEK-LDDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLS 376
            L     + EK LD+     K    N  ++     H    +  DL+ ++  L  Q  ++  
Sbjct: 629  LEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKE 688

Query: 377  ---------EEEKAFLQ----KQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLIT- 422
                     EEEK  LQ    ++K H + + +L    + +  L+Q +   +   EGL + 
Sbjct: 689  AHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSS 748

Query: 423  ------LQELQQATKTVYQQQIKIL--SANLERESQRCVITQWKMACLRKKHA------- 467
                  ++ L Q  +  +Q+Q+  L     LE+E  R  + +     L++          
Sbjct: 749  AWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECN 808

Query: 468  RWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFV 527
            R T++I+A+ Q+  +K+       ++ L E  +RQ        +++ L  + +EE+  + 
Sbjct: 809  RRTSQIEAQFQSDCQKVTERCESALQSL-EGRYRQ--------ELKDLQEQQREEKSQWE 859

Query: 528  NKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYK--------EKRRKL 579
             ++  L +E ++ +E+ +KET + +EK   LV    + ++ E+ YK        E+++ L
Sbjct: 860  FEKDELTQECAEAQEL-LKET-LKREKTTSLV-LTQEREMLEKTYKEHLNSMVVERQQLL 916

Query: 580  EELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDV-----------KQELQQLRDQE 628
            ++L ++      ++ LL++ I        R +   E+V            Q L++L  + 
Sbjct: 917  QDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEH 976

Query: 629  SKKNKDHFETLKNLENGFYINDQKADLLLLENKKLKEYILYLKNNIEKYREGQEALMHTS 688
             ++ ++    L  +EN      + AD    E  ++   I  L++ I++ ++    L    
Sbjct: 977  DQERQEMMSKLLAMENIHKATCETAD---RERAEMSTEISRLQSKIKEMQQATSPLSMLQ 1033

Query: 689  NDLSRQLIAQEAQYKD-LWAEFQTTVKILVDNGEETL 724
            +    Q+I +E    D   +  Q   ++L +NG+  L
Sbjct: 1034 SGC--QVIGEEEVEGDGALSLLQQGEQLLEENGDVLL 1068



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 78/416 (18%), Positives = 186/416 (44%), Gaps = 43/416 (10%)

Query: 65   EEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRE-----LEE 119
            EE K  + D+ +   ++++     ++LL  ES +L +   +L     ++  E     L+ 
Sbjct: 1489 EELKAMMHDLQITCSEMQQK----VELLRYESEKLQQENSILRNEITTLNEEDSISNLKL 1544

Query: 120  CVRDARRLNLFE-INTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHAR-- 176
               +  +  +++   T+K      +  +E LKK+I++L   N+ L  +  EL++K+++  
Sbjct: 1545 GTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQ 1604

Query: 177  -FVLSLNQTM-------EKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKERA 228
              +  LNQ +       EK+   +        K NLK E     ++C  ++  L+    A
Sbjct: 1605 EKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEE----LERCKVQSSTLVSSLEA 1660

Query: 229  EYLIRKQELTAQINEFEN---TREVKRMETYQKKKELDKLQTKMSKI----------KET 275
            E  + + ++   I + EN     E+++M+   +  +L   Q K+S +          KE 
Sbjct: 1661 E--LSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEA 1718

Query: 276  VTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDE 335
            ++       D   + + L   I   +QE    +   A L+++L     ++EK+ ++ +  
Sbjct: 1719 LSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQL---VASQEKVQNLEDTV 1775

Query: 336  KNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQ 395
            +N  L ++ ++   L   + E + L++++ +L +Q +    +     +        NQ++
Sbjct: 1776 QNVNL-QMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQK 1834

Query: 396  LTFISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSANLERESQR 451
                 + ++ +++++  +    E L T+ +  +A  T  +++++ L +NL  + Q+
Sbjct: 1835 RLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQK 1890



 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 134/658 (20%), Positives = 264/658 (40%), Gaps = 109/658 (16%)

Query: 202 INLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVKRMETYQKKKE 261
           INL    +AL+ + +     + +   A +    + L  +++              Q  +E
Sbjct: 337 INLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVD--------------QVVRE 382

Query: 262 LDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHE-SIRYWEQEVSE----LKKDLAILEA 316
            +KL++ + K ++  ++ A+ + DH+  I R +E ++R  ++E  E    LK +L   E 
Sbjct: 383 KEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELR-KER 441

Query: 317 KLCFFTDNKEKLD-------------------DISNDEKNEFLNKIKQLVETLHAARMEY 357
           +       K++L+                    +S  E +   N++ +  E L     EY
Sbjct: 442 EQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKL----AEY 497

Query: 358 KDLREKMK-----TLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVD 412
           ++L  K++      LA ++  +     + FLQ++++      Q+    +++  + Q +VD
Sbjct: 498 ENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERL-----TQMRNEYERQCRVLQDQVD 552

Query: 413 --IKNMEEGLITLQELQQATKTVYQQQIKILSANLERE----SQRC-----------VIT 455
                +EE     + L+   K    ++++  S  +E E    S+ C           VI 
Sbjct: 553 ELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIE 612

Query: 456 QWK------MACLR---KKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEIS 506
           Q K      + CLR   +   R   K   E     +K Q    +R E  NET   +++IS
Sbjct: 613 QMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHE--NETHTLEKQIS 670

Query: 507 GF---VAQIEKLTTELKE--EEKAFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEY 561
                +A+++     LKE   E    ++E+    ++   EE    + ++  + E EL   
Sbjct: 671 DLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKAR 730

Query: 562 LPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQEL 621
           L Q Q + +  +E  +        +    QE  L   H    T    ++    E++++EL
Sbjct: 731 LTQAQASFEREREGLQSSAWTEEKVRGLTQE--LEQFHQEQLTSLVEKHTLEKEELRKEL 788

Query: 622 QQLRDQESKKNKDHFETLKN-----LENGFYINDQK------ADLLLLENKKLKEYILYL 670
            +   +E ++ ++  ET  N     +E  F  + QK      + L  LE +  +E    L
Sbjct: 789 LEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQE----L 844

Query: 671 KNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTTVKILVDNGEETLQDI-NN 729
           K+  E+ RE +       ++L+++    +   K+     +TT  +L    E   +    +
Sbjct: 845 KDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEH 904

Query: 730 LTDKLRERDEKMQHVSTWLRGSLEGLRLLVEQESPMDLLSKQQLRALLVTSKEEKTCQ 787
           L   + ER + +Q +      S     LL +Q   +    K++LR      +EE  CQ
Sbjct: 905 LNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELR-----EREEVLCQ 957


>gi|148536869 ninein isoform 2 [Homo sapiens]
          Length = 2133

 Score = 93.6 bits (231), Expect = 7e-19
 Identities = 166/744 (22%), Positives = 322/744 (43%), Gaps = 123/744 (16%)

Query: 140  TRTE-----NEIELLKKKITDLTKYNEALGEKQEELARKHARFVLSLNQTMEKKATTTVY 194
            TRTE     N+I  L++++  L    +   EK+++L      F +S+   ++KK      
Sbjct: 1189 TRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLL-----FDVSV---LKKKLKMLER 1240

Query: 195  INETYTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVKRME 254
            I E   K  L  ED++ +  C+QE   +ME    E L   +ELTA++  F    E+K+ME
Sbjct: 1241 IPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEV--FRLQDELKKME 1298

Query: 255  TYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAIL 314
                  E+ +    + K  + V +    L   N+ + RL   I   ++ V + + D  + 
Sbjct: 1299 ------EVTETFLSLEKSYDEVKIENEEL---NVLVLRLQGKIEKLQESVVQ-RCDCCLW 1348

Query: 315  EAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYK----------DLREKM 364
            EA L    +N E   D +  + N+ L +    V ++H    E K           L EK+
Sbjct: 1349 EASL----ENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKV 1404

Query: 365  KT--LARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLIT 422
            K   +A  +  + + +E+  +Q Q I +EN   L F  Q ++F  Q +  I  +E     
Sbjct: 1405 KAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGF--QDKHF--QHQATIAELELEKTK 1460

Query: 423  LQELQQATK---TVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKAE-IQ 478
            LQEL +  K   T+  +Q  +LS   + E  + ++   ++ C   +      + ++E +Q
Sbjct: 1461 LQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQ 1520

Query: 479  AITEKIQNAEVRRIELLNE----TSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLM 534
                 ++N     I  LNE    ++ +   ++G   ++ + T  +K+E  A     + L 
Sbjct: 1521 QENSILRN----EITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLK 1576

Query: 535  KELS----KYEEIFVKETQI------NKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSN 584
            K++S    K +++ ++ T++      N+EK +EL + L ++ + ++E +     LEE   
Sbjct: 1577 KQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEM-LCQKEKEPGNSALEE--- 1632

Query: 585  IITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQ---QLRDQESKKNKDHFETLKN 641
                + QE+  L   +       S  +S++E    E++    +  QE+   KD  E +K 
Sbjct: 1633 ----REQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQ 1688

Query: 642  LENGFYIND--QKADLLLLENKKL---KEYI--------------LYLKNNIEKYREGQE 682
            L     ++D  QK   +L  N+KL   KE +                L++ I   ++ Q+
Sbjct: 1689 LHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQK 1748

Query: 683  ALMHTSNDLSRQLIAQEAQYKDL----------WAEFQTTVKILVDNGEETLQDINNLTD 732
            +  H S  L  QL+A + + ++L           +  ++ +++     E   Q++ +L  
Sbjct: 1749 SWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHK 1808

Query: 733  KLRERDEK--MQHVSTWLRG--------SLEGLRLLVEQESPMDLLSKQQLRALL----- 777
            +L+    K     ++T   G        S + L  L+ +E  +     ++L+ ++     
Sbjct: 1809 QLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKA 1868

Query: 778  -VTSKEEKTCQLSDLVIPNYATNI 800
             +T   EK  QL   ++P +  ++
Sbjct: 1869 ELTHSREKVRQLESNLLPKHQKHL 1892



 Score = 80.1 bits (196), Expect = 8e-15
 Identities = 155/757 (20%), Positives = 315/757 (41%), Gaps = 120/757 (15%)

Query: 66   EAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPNSI--KRELEECVRD 123
            +  I L ++ +A++    + K +I    + S +  ++ +LLE +   +  K +L   +  
Sbjct: 334  DGNINLTELTLALENELLVTKNSIHQAALASFKA-EIRHLLERVDQVVREKEKLRSDLDK 392

Query: 124  ARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFV----- 178
            A +L     + +       E   E   +K+ +  +Y E +   + EL ++  + +     
Sbjct: 393  AEKLKSLMASEVDDHHAAIERRNEYNLRKLDE--EYKERIAALKNELRKEREQILQQAGK 450

Query: 179  --LSLNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKER--------- 227
              L L Q +EK  T   YI +    ++LK E+  L+ + ++ AE+L E E          
Sbjct: 451  QRLELEQEIEKAKTEENYIRDRLA-LSLK-ENSRLENELLENAEKLAEYENLTNKLQRNL 508

Query: 228  ---------------AEYLIRKQELTAQINEFENTREV---------KRMETYQKKKELD 263
                           AE+ ++++ LT   NE+E    V           +E Y+ +  + 
Sbjct: 509  ENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVL 568

Query: 264  KLQTKMSKIKETVTVSAAVLSDHNL---EIARLHESIR---YWEQEVSELKKDLAILEAK 317
            +L  K S  +E    S  +  +H L   E   L+ SI      EQ   +  +D+  L  +
Sbjct: 569  RLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLE 628

Query: 318  LCFFTDNKEK-LDDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLS 376
            L     + EK LD+     K    N  ++     H    +  DL+ ++  L  Q  ++  
Sbjct: 629  LEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKE 688

Query: 377  ---------EEEKAFLQ----KQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLIT- 422
                     EEEK  LQ    ++K H + + +L    + +  L+Q +   +   EGL + 
Sbjct: 689  AHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSS 748

Query: 423  ------LQELQQATKTVYQQQIKIL--SANLERESQRCVITQWKMACLRKKHA------- 467
                  ++ L Q  +  +Q+Q+  L     LE+E  R  + +     L++          
Sbjct: 749  AWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECN 808

Query: 468  RWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFV 527
            R T++I+A+ Q+  +K+       ++ L E  +RQ        +++ L  + +EE+  + 
Sbjct: 809  RRTSQIEAQFQSDCQKVTERCESALQSL-EGRYRQ--------ELKDLQEQQREEKSQWE 859

Query: 528  NKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYK--------EKRRKL 579
             ++  L +E ++ +E+ +KET + +EK   LV    + ++ E+ YK        E+++ L
Sbjct: 860  FEKDELTQECAEAQEL-LKET-LKREKTTSLV-LTQEREMLEKTYKEHLNSMVVERQQLL 916

Query: 580  EELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDV-----------KQELQQLRDQE 628
            ++L ++      ++ LL++ I        R +   E+V            Q L++L  + 
Sbjct: 917  QDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEH 976

Query: 629  SKKNKDHFETLKNLENGFYINDQKADLLLLENKKLKEYILYLKNNIEKYREGQEALMHTS 688
             ++ ++    L  +EN      + AD    E  ++   I  L++ I++ ++    L    
Sbjct: 977  DQERQEMMSKLLAMENIHKATCETAD---RERAEMSTEISRLQSKIKEMQQATSPLSMLQ 1033

Query: 689  NDLSRQLIAQEAQYKD-LWAEFQTTVKILVDNGEETL 724
            +    Q+I +E    D   +  Q   ++L +NG+  L
Sbjct: 1034 SGC--QVIGEEEVEGDGALSLLQQGEQLLEENGDVLL 1068



 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 118/641 (18%), Positives = 253/641 (39%), Gaps = 131/641 (20%)

Query: 65   EEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRE-----LEE 119
            EE K  + D+ +   ++++     ++LL  ES +L +   +L     ++  E     L+ 
Sbjct: 1489 EELKAMMHDLQITCSEMQQK----VELLRYESEKLQQENSILRNEITTLNEEDSISNLKL 1544

Query: 120  CVRDARRLNLFE-INTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHAR-- 176
               +  +  +++   T+K      +  +E LKK+I++L   N+ L  +  EL++K+++  
Sbjct: 1545 GTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQ 1604

Query: 177  -FVLSLNQTM-------EKKATTTVYINETYTKINLKRE--------------------D 208
              +  LNQ +       EK+   +        K NLK E                    +
Sbjct: 1605 EKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSE 1664

Query: 209  IALQKKCIQEAEELMEKE--------------------------RAEYLIRKQELTAQIN 242
            + +Q   +Q+   L++ E                            + L  K+ L+ ++N
Sbjct: 1665 VKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELN 1724

Query: 243  E----------FENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIAR 292
                        E+     + E    + +   L++++   +E V      + + NL+++R
Sbjct: 1725 SCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSR 1784

Query: 293  LHESIRYWEQEVSELKKDLAILEAKL-----------------CFFTDNK----EKLDDI 331
            +   +R  +QE   LK+++  L  +L                       K    +KLD +
Sbjct: 1785 MKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHL 1844

Query: 332  SNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDE 391
             N+E+     + ++L   +   + E    REK++ L      +L + +K       ++  
Sbjct: 1845 MNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESN---LLPKHQKHLNPSGTMNPT 1901

Query: 392  NQKQLTFISQKEYF------LSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSANL 445
             Q++L+   + + F       ++K   + ++E+ L T+    +  K   ++Q+K+    +
Sbjct: 1902 EQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLK---KKQVKLDEQLM 1958

Query: 446  ERESQRCVIT------QWKMACLRKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETS 499
            E +  R   T       W +  L+++        + +   +  ++  AE     L  E  
Sbjct: 1959 EMQHLRSTATPSPSPHAWDLQLLQQQACPMVP--REQFLQLQRQLLQAERINQHLQEELE 2016

Query: 500  FRQQEISGFVAQIEKLTTELKEE----EKAFVNKEKMLMKELSKYEEIFVKETQIN---K 552
             R  E +      E+L T ++E     E+     +++L +++++ +E   K T+ +   K
Sbjct: 2017 NRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQLCKNTKADAMVK 2076

Query: 553  EKEEELVEYLPQLQVAEQEYKEKRRK---LEE----LSNII 586
            +   E  + L  L+V EQ  K   +K   LEE    LSNI+
Sbjct: 2077 DLYVENAQLLKALEVTEQRQKTAEKKNYLLEEKIASLSNIV 2117



 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 134/658 (20%), Positives = 264/658 (40%), Gaps = 109/658 (16%)

Query: 202 INLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVKRMETYQKKKE 261
           INL    +AL+ + +     + +   A +    + L  +++              Q  +E
Sbjct: 337 INLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVD--------------QVVRE 382

Query: 262 LDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHE-SIRYWEQEVSE----LKKDLAILEA 316
            +KL++ + K ++  ++ A+ + DH+  I R +E ++R  ++E  E    LK +L   E 
Sbjct: 383 KEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELR-KER 441

Query: 317 KLCFFTDNKEKLD-------------------DISNDEKNEFLNKIKQLVETLHAARMEY 357
           +       K++L+                    +S  E +   N++ +  E L     EY
Sbjct: 442 EQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKL----AEY 497

Query: 358 KDLREKMK-----TLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVD 412
           ++L  K++      LA ++  +     + FLQ++++      Q+    +++  + Q +VD
Sbjct: 498 ENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERL-----TQMRNEYERQCRVLQDQVD 552

Query: 413 --IKNMEEGLITLQELQQATKTVYQQQIKILSANLERE----SQRC-----------VIT 455
                +EE     + L+   K    ++++  S  +E E    S+ C           VI 
Sbjct: 553 ELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIE 612

Query: 456 QWK------MACLR---KKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEIS 506
           Q K      + CLR   +   R   K   E     +K Q    +R E  NET   +++IS
Sbjct: 613 QMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHE--NETHTLEKQIS 670

Query: 507 GF---VAQIEKLTTELKE--EEKAFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEY 561
                +A+++     LKE   E    ++E+    ++   EE    + ++  + E EL   
Sbjct: 671 DLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKAR 730

Query: 562 LPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQEL 621
           L Q Q + +  +E  +        +    QE  L   H    T    ++    E++++EL
Sbjct: 731 LTQAQASFEREREGLQSSAWTEEKVRGLTQE--LEQFHQEQLTSLVEKHTLEKEELRKEL 788

Query: 622 QQLRDQESKKNKDHFETLKN-----LENGFYINDQK------ADLLLLENKKLKEYILYL 670
            +   +E ++ ++  ET  N     +E  F  + QK      + L  LE +  +E    L
Sbjct: 789 LEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQE----L 844

Query: 671 KNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTTVKILVDNGEETLQDI-NN 729
           K+  E+ RE +       ++L+++    +   K+     +TT  +L    E   +    +
Sbjct: 845 KDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEH 904

Query: 730 LTDKLRERDEKMQHVSTWLRGSLEGLRLLVEQESPMDLLSKQQLRALLVTSKEEKTCQ 787
           L   + ER + +Q +      S     LL +Q   +    K++LR      +EE  CQ
Sbjct: 905 LNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELR-----EREEVLCQ 957


>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 828

 Score = 92.8 bits (229), Expect = 1e-18
 Identities = 151/716 (21%), Positives = 304/716 (42%), Gaps = 81/716 (11%)

Query: 98  ELNKLYYLLETLPNSIKRELEECV--RDARRLNLFEINTIKMRITRTENEIELLKKKITD 155
           EL +    + T      R +EE    RDA  L L+  NTI     + +N     K ++ +
Sbjct: 142 ELQRALSAVSTWHKKADRYIEELTKERDALSLELYR-NTITNEELKKKNAELQEKLRLAE 200

Query: 156 LTKYNEALGEKQEELARKHARFVLSLNQT---MEKKATTTVYINETYTKINLKREDIALQ 212
             K    L  K+ +   + A+F+L   QT    E+       + E   KI  + E +  Q
Sbjct: 201 SEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQ 260

Query: 213 KKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVKRMETYQKKKELDKLQTKMSKI 272
           ++ ++E E  M ++  E  +R+QE   +  E E   + K +   +++K+L + + +M + 
Sbjct: 261 EERLREQEGKMREQ--EEKMRRQEKRLREQEKELREQEKEL---REQKKLREQEEQMQEQ 315

Query: 273 KETVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKL--DD 330
           +E +      + +   ++ R  E  R WEQE     K +   E K+    D +E++   D
Sbjct: 316 EEKMWEQEEKMREQEEKMWRQEE--RLWEQE-----KQMREQEQKM---RDQEERMWEQD 365

Query: 331 ISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHD 390
               EK E + + +++ E     + E + +RE+ K +  + + +  +EEK   Q++ + +
Sbjct: 366 ERLREKEERMREQEKMWEQEEKMQEEER-IREREKKMREEEETMREQEEKMQKQEENMWE 424

Query: 391 ENQKQLTFISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSANLERESQ 450
           + +K+            Q+R  +   +E L   +++Q+  + +++Q+ KI         +
Sbjct: 425 QEEKEW----------QQQR--LPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQE 472

Query: 451 RCVITQWKMACLRKKHARWTAKIKAEIQAITEKIQNAEVR---RIELLNETSFRQQEISG 507
           + +  Q KM    ++   W  + K   Q   +K+ + E R   + E L E   R +E   
Sbjct: 473 KKMWRQEKMR--EQEDQMWEQEEKMRDQE--QKMWDQEERMWEQDERLREKEERMREQKK 528

Query: 508 FVAQIEKLTTELKEEEKAFVNKEKML--MKELSKYEEIFVKETQINKEKEEELVEYLPQL 565
              Q EK+      EEK    +EK     +E  + EE   +  +  +E+EE + E   ++
Sbjct: 529 MWQQEEKM-----REEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKM 583

Query: 566 QVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQQLR 625
           Q  E++ +E+  K+ E       Q QEE +      ++ ++    +   E++  E ++  
Sbjct: 584 QEQEEKMREQEEKMWEQEE--KMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKM 641

Query: 626 DQESKKNKDHFETLKNLENGFYINDQKADLLLLENKKLKEYILYLKNNIEKYREGQEALM 685
            ++ +K  +  E ++  E      ++K   +  + +K++E    ++   EK RE +E + 
Sbjct: 642 QEQEEKMWEQEEKMREQEEKMREQEEK---MQGQEEKMREQEEKMQGQEEKMREQEEKMR 698

Query: 686 HTSNDLSRQLIAQEAQYKDLWAEFQTTVKILVDNGEETLQD-INNLTDKLRERDEK---- 740
                +  Q      Q + +W + +   K      EE ++D    + ++L E +E+    
Sbjct: 699 GQEEKMWGQEEKMWGQEEKMWGQEEMREK------EERIRDQKEKMQERLPEHEERCSEP 752

Query: 741 ----------MQHVSTWLRGSLEGLRLLVEQESPMDLLSKQQLRALLVTSKEEKTC 786
                     M H      GS+E       + SP D  + Q++  L    K  + C
Sbjct: 753 CLPPSKVLCNMSHT-----GSVEPAGGEAGEGSPQDNPTAQEIMQLFCGMKNAQQC 803


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 129/653 (19%), Positives = 284/653 (43%), Gaps = 89/653 (13%)

Query: 140  TRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFVLSLNQTMEKKATTTVYINETY 199
            T+ E E+  LKK + + TK +EA   + +++ ++HA  +  L++ +E+       + +  
Sbjct: 1170 TKREQEVAELKKALEEETKNHEA---QIQDMRQRHATALEELSEQLEQAKRFKANLEKNK 1226

Query: 200  TKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVKRMETYQKK 259
              +    +++A + K +Q+ +   E +R +   + QEL A+++E +  R     +  + +
Sbjct: 1227 QGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQ 1286

Query: 260  KELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLC 319
             ELD + T + +                             E++  +  KD A LE++L 
Sbjct: 1287 NELDNVSTLLEEA----------------------------EKKGIKFAKDAASLESQL- 1317

Query: 320  FFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLSEEE 379
               D +E L + +  + N   ++I+QL E  ++ + + ++  E  K L +Q   VL+ + 
Sbjct: 1318 --QDTQELLQEETRQKLN-LSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQ---VLALQS 1371

Query: 380  KAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIK 439
            +    K+K+ D+     +    K+  L       + +EE  +   +L++ TK   QQ++ 
Sbjct: 1372 QLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEK-TKNRLQQELD 1430

Query: 440  ILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETS 499
             L+ +L+ + Q         + L KK  ++  ++ AE ++I+ +      R      E  
Sbjct: 1431 DLTVDLDHQRQ-------VASNLEKKQKKFD-QLLAEEKSISARYAEERDRA-----EAE 1477

Query: 500  FRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSKYEEIFVKETQINKEKEEELV 559
             R++E       + +   E  E ++ F  + K L  ++   E++   +  + K     + 
Sbjct: 1478 AREKETKAL--SLARALEEALEAKEEFERQNKQLRADM---EDLMSSKDDVGK----NVH 1528

Query: 560  EYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQ 619
            E     +  EQ+ +E R +LEEL + + A    +  L  ++      F R +   ++  +
Sbjct: 1529 ELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNE 1588

Query: 620  E-----LQQLRDQESKKNKDHFE-------------TLKNLENGFYINDQKADLLLLENK 661
            E     ++Q+R+ E++   +  +              LK+LE      ++  D ++ + +
Sbjct: 1589 EKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLR 1648

Query: 662  KLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTTVKIL--VDN 719
            KL+  +   +  +E+ R  ++ +   S +  ++L + EA+   L  E  ++ +     + 
Sbjct: 1649 KLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQ 1708

Query: 720  GEETLQD--INNLTDKLRERDEKMQHVSTWLRGSLEGL-RLLVEQESPMDLLS 769
              + L D   N+ + K    DEK +     L   +  L   L E++S M+LL+
Sbjct: 1709 ERDELADEITNSASGKSALLDEKRR-----LEARIAQLEEELEEEQSNMELLN 1756



 Score = 84.3 bits (207), Expect = 4e-16
 Identities = 124/670 (18%), Positives = 284/670 (42%), Gaps = 98/670 (14%)

Query: 137  MRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFVLSLNQTMEKKATTTVYIN 196
            +++TR E E++   +++  + +    +  + EE+ RKH        Q +E+K        
Sbjct: 845  LQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKH-------QQLLEEK-------- 889

Query: 197  ETYTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVKRMETY 256
                  N+  E +  + +   EAEE+    RA    +KQEL   +++ E+  E +     
Sbjct: 890  ------NILAEQLQAETELFAEAEEM----RARLAAKKQELEEILHDLESRVEEEEERNQ 939

Query: 257  QKKKELDKLQTKMSKIKETVTVSAAVLSDHNLE-------IARLHESIRYWEQEVSELKK 309
              + E  K+Q  +  ++E +           LE       I ++ E I   E + S+  K
Sbjct: 940  ILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIK 999

Query: 310  DLAILEAKLC----FFTDNKEKLDDIS--NDEKNEFLNKIKQLVETLHAARMEYKDLREK 363
            +  ++E ++        + +EK  +++   +++   ++ +++ ++     R E +  + K
Sbjct: 1000 EKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRK 1059

Query: 364  M----KTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEG 419
            +      L  Q   + ++ ++  LQ  K  +E Q  L     +    +     ++ ++  
Sbjct: 1060 LDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQ 1119

Query: 420  LITLQ---ELQQATKTVYQQQIKILSANLE---RESQRCVITQWKMACLRKKHARWTAKI 473
            +  LQ   E ++A++   ++Q + LS  LE    E +  + T      LR K  +  A++
Sbjct: 1120 IAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAEL 1179

Query: 474  KAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKML 533
            K   +A+ E+ +N E +  ++    +   +E+S  + Q ++    L++ ++      K L
Sbjct: 1180 K---KALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKEL 1236

Query: 534  MKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQ---EYKEKRRKLE-ELSNIITAQ 589
              E+   +++  +     K+ + ++ E   ++   ++   E  EK  KL+ EL N+ T  
Sbjct: 1237 ACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLL 1296

Query: 590  RQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNLENGFYIN 649
             + E             F++  +++E   Q+ Q+L  +E+++  +    ++ LE      
Sbjct: 1297 EEAEKK--------GIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEE---- 1344

Query: 650  DQKADLLLLENKKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEF 709
                                 KN++++ +E +E       +L +Q++A ++Q  D   + 
Sbjct: 1345 ---------------------KNSLQEQQEEEE---EARKNLEKQVLALQSQLADTKKKV 1380

Query: 710  QT---TVKILVDNGEETLQDINNLTDKLRERD---EKMQHVSTWLRGSLEGLRL-LVEQE 762
                 T++ L +  ++ L+D   L+ +L E+    +K++     L+  L+ L + L  Q 
Sbjct: 1381 DDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQR 1440

Query: 763  SPMDLLSKQQ 772
                 L K+Q
Sbjct: 1441 QVASNLEKKQ 1450



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 66/327 (20%), Positives = 146/327 (44%), Gaps = 52/327 (15%)

Query: 460  ACLRKKHARWT---AKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLT 516
            A L+ +H +W     K+K  +Q +T + +  + +  ELL +   +Q ++ G         
Sbjct: 825  AYLKLRHWQWWRVFTKVKPLLQ-VTRQEEELQAKDEELL-KVKEKQTKVEG--------- 873

Query: 517  TELKEEEKAFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKR 576
             EL+E E+    K + L++E +   E    ET++  E EE                  K+
Sbjct: 874  -ELEEMER----KHQQLLEEKNILAEQLQAETELFAEAEE-----------MRARLAAKK 917

Query: 577  RKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHF 636
            ++LEE+ + + ++ +EE+  N  +    +    +I ++E      +QL ++E  + K   
Sbjct: 918  QELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLE------EQLDEEEGARQKLQL 971

Query: 637  ETLKNLENGFYINDQKADLLLLENKKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLI 696
            E +            +A +     KK++E IL L++   K+ + ++ +     + S QL 
Sbjct: 972  EKV----------TAEAKI-----KKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLA 1016

Query: 697  AQEAQYKDLWAEFQTTVKILVDNGEETLQDINNLTDKLRERDEKMQHVSTWLRGSLEGLR 756
             +E + K+L A+ +   ++++ + EE L+       +L +   K+   +T L+  +  L+
Sbjct: 1017 EEEEKAKNL-AKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQ 1075

Query: 757  LLVEQESPMDLLSKQQLRALLVTSKEE 783
              +++        +++L+  L    +E
Sbjct: 1076 AQIDELKLQLAKKEEELQGALARGDDE 1102



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 84/421 (19%), Positives = 180/421 (42%), Gaps = 42/421 (9%)

Query: 394  KQLTFISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIK---ILSANLERESQ 450
            K L  ++++E  L  K  ++  ++E    ++   +  +  +QQ ++   IL+  L+ E++
Sbjct: 842  KPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETE 901

Query: 451  RCVITQWKMACLRKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVA 510
                       L  +     A++ A+ Q + E + + E R  E        Q E     A
Sbjct: 902  -----------LFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQA 950

Query: 511  QIEKLTTELKEEEKAFVNKEKMLMKELSKY-------EEIFVKETQINKE-KEEELVEYL 562
             I+ L  +L EEE A   ++K+ +++++         EEI + E Q +K  KE++L+E  
Sbjct: 951  HIQDLEEQLDEEEGA---RQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDR 1007

Query: 563  P---QLQVAEQEYKEK-----RRKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNM 614
                  Q+AE+E K K     R K E + + +  + ++E+     +    R      +++
Sbjct: 1008 IAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDL 1067

Query: 615  EDVKQELQ----QLRDQESKKNKDHFETLKNLENGFYINDQKADLLLLENKKLKEYILYL 670
            +D   ELQ    +L+ Q +KK ++    L   ++     +    ++    ++L+  I  L
Sbjct: 1068 QDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVV----RELQAQIAEL 1123

Query: 671  KNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTTVKILVDNGEETLQDINNL 730
            + + E  +  +        DLS +L A + + +D         ++     +E  +    L
Sbjct: 1124 QEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKAL 1183

Query: 731  TDKLRERDEKMQHVSTWLRGSLEGLRLLVEQESPMDLLSKQQLRALLVTSKEEKTCQLSD 790
             ++ +  + ++Q +      +LE L   +EQ       + ++ +  L T  +E  C++  
Sbjct: 1184 EEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFK-ANLEKNKQGLETDNKELACEVKV 1242

Query: 791  L 791
            L
Sbjct: 1243 L 1243



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 80/389 (20%), Positives = 164/389 (42%), Gaps = 53/389 (13%)

Query: 79   KKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEECVR-------DARRLNLFE 131
            +++EEMR   ++ LE E          LE    ++K + E  ++       + +RL + +
Sbjct: 1539 QQVEEMR-TQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQ 1597

Query: 132  INTIKMRIT--RTENEIELLKKK-----ITDLTKYNEALGEKQEELARKHARFVLSLNQT 184
            +  ++  +   R +  + +  KK     + DL    EA  + ++E+ ++  +    +   
Sbjct: 1598 VRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDY 1657

Query: 185  MEKKATTTVYINETYTKINLKREDI-ALQKKCIQEAEELMEKERAEYLIRKQ--ELTAQI 241
              +        +E + +     + + +L+ + +Q  EEL   ERA     ++  EL  +I
Sbjct: 1658 QRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEI 1717

Query: 242  NEFENTR-----EVKRMETY--QKKKELDKLQTKMSKI-----KETVTV----------- 278
                + +     E +R+E    Q ++EL++ Q+ M  +     K T+ V           
Sbjct: 1718 TNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAER 1777

Query: 279  SAAVLSDH-NLEIARLHESIRYWEQEV-----SELKKDLAILEAKLCFFTDNKE---KLD 329
            SAA  SD+   ++ R ++ ++   QE+     S+ K  ++ LEAK+    +  E   K  
Sbjct: 1778 SAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKER 1837

Query: 330  DISNDEKNEFLNKIKQL---VETLHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQ 386
              +N        K+K++   VE       +YK+  EK     +Q K  L E E+   +  
Sbjct: 1838 AAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRAN 1897

Query: 387  KIHDENQKQLTFISQKEYFLSQKRVDIKN 415
                + Q++L   ++    LS++   +KN
Sbjct: 1898 ASRRKLQRELDDATEANEGLSREVSTLKN 1926


>gi|221219020 NYD-SP11 protein [Homo sapiens]
          Length = 2873

 Score = 92.0 bits (227), Expect = 2e-18
 Identities = 160/679 (23%), Positives = 309/679 (45%), Gaps = 77/679 (11%)

Query: 147  ELLKKKITDLTKYNEALGEKQEELARKHARFVLSLNQTME--KKATTTVYI---NETYTK 201
            ++++    ++ ++ E +  ++EE A+K AR +L L +T    KK    +++   N T  K
Sbjct: 1327 DMIQGVTQEVIRHKEVM-PREEEQAQKKARDMLGLEETQVILKKGKKVIFLEPGNVTMGK 1385

Query: 202  INLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVKRMETYQKKKE 261
               K+E+    +K  ++  + ++KER    I K+E+T +  E + + EV+ M T ++K  
Sbjct: 1386 EISKKEEKKTFQKSPKQGRKAVQKERKVGKI-KREMTKE--ERDMSEEVEEMATLEEK-- 1440

Query: 262  LDKLQTKMSKIKETVTVSAAVLSDHNLEIARLH-ESIRYWEQEVSELKKDLAILEAKLCF 320
            + K + K+  I+ T +      +    E  ++H E+ + W+    E +K L   E KL  
Sbjct: 1441 VVKQEGKLVMIERTPSWQDWKKAWD--EWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQ 1498

Query: 321  FTDNKEKLDDISNDEKNEFLNKIKQLVETLHAAR---MEYKDLREKMKTLARQYKIVLSE 377
              +     +++  ++K     + KQ+ E + +++    +YKD  E+  TL  +      E
Sbjct: 1499 AGEKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKD--EEEVTLEEEVSREGEE 1556

Query: 378  EEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLITLQE--LQQATKTVYQ 435
            +E+   ++Q+ H + + +   I +K     +KR      EE  +  +E  L Q  + + Q
Sbjct: 1557 KEQQVTEEQR-HIQEEHKWARIHRKRARAEKKRA----QEERKLAQEEEKLAQEERQLAQ 1611

Query: 436  QQIKILSA--NLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAITEKIQNAE----- 488
            ++ K+  A   + ++ +     + K A   +  A+   K+  E + + +K +        
Sbjct: 1612 EERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEK 1671

Query: 489  -VRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSK----YEEI 543
              R  E L +   +  E+   +AQ      EL + E+    +EK L +EL +     EE+
Sbjct: 1672 VAREEEKLAKKGGKLAEVKNILAQ---KVEELPQREQNLDWQEKELAQELEELEWDMEEL 1728

Query: 544  FVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHIFLF 603
              KE ++N+E E +LVE   +L   E+    +R KL E     T   QEE+LL       
Sbjct: 1729 SWKEEELNQE-EGKLVEEKKKLAEEEEALAWQREKLSEEE---TKLAQEEELLIQEKEKL 1784

Query: 604  TRDFSRYISNMEDVKQELQQLRDQESK---KNKDHFETLKNLENGFYINDQKADL----- 655
             +   +     E + ++ +QL +++ K   K +    +++ L     I  QK +L     
Sbjct: 1785 AQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKK 1844

Query: 656  -LLLENKKL---KEYILYLKNNIEKYREGQEALMHTSNDLS--RQLIAQEAQYKDLWAEF 709
             L  E +KL   KE +LY   N E+    ++ L+   N L    +++AQ  +   L  E 
Sbjct: 1845 NLAQEKEKLAQRKENLLY---NKERLTHSKKQLVQVKNKLGMFNKILAQVEE--KLTQEK 1899

Query: 710  QTTVKILVDNGEETLQDINNLTDKLRERDEKMQHVSTWLRGSLEGLRLLVEQESPMDLLS 769
            +T +K   +   ET + +  + D L ++ EK+         + E ++L +E+     +  
Sbjct: 1900 ETVIK-KKEKLAETEKKLVQVEDSLAKKQEKL---------AQEKMKLALEKAM---VQG 1946

Query: 770  KQQLRALLVTSKEEKTCQL 788
            K++LR  L  +KEEK   L
Sbjct: 1947 KKRLRGELDIAKEEKALNL 1965



 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 101/467 (21%), Positives = 223/467 (47%), Gaps = 29/467 (6%)

Query: 141  RTENEIELLKKKITDLTKYNEALGEKQEELARKH--ARFVLSLNQTMEKKATTTVYINET 198
            + E E+ L ++   +  +  + + E+Q  +  +H  AR      +  +K+A     + + 
Sbjct: 1539 KDEEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQE 1598

Query: 199  YTKINLKREDIALQKKCIQEA-----EELMEKERAE-YLIRKQELTAQINEFENTREVKR 252
              K+  +   +A +++ + +A     ++  E  +AE    +K+E  AQ  E + ++E ++
Sbjct: 1599 EEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGE-KLSQEAEK 1657

Query: 253  METYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLA 312
            +   QK+K+L K   K+++ +E +      L++    +A+  E +   EQ +   +K+LA
Sbjct: 1658 LA--QKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELA 1715

Query: 313  ILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYK 372
                +L +  +     ++  N E+ + + + K+L E   A   + + L E+   LA++ +
Sbjct: 1716 QELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEE 1775

Query: 373  IVLSEEEKAFLQKQKIHDENQ---KQLTFISQKEYFLSQKRVD-IKNMEE------GLIT 422
            +++ E+EK    K+K+ +E +   ++   + +K+  L+QKR   I +MEE       L  
Sbjct: 1776 LLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQ 1835

Query: 423  LQELQQATKTVYQQQIKIL--SANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAI 480
             + L Q  K + Q++ K+     NL    +R   ++ ++  ++ K   +  KI A+++  
Sbjct: 1836 KKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKLGMFN-KILAQVEEK 1894

Query: 481  TEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEE---EKAFVNKEKMLMKEL 537
              + +   +++ E L ET  +  ++   +A+ ++   + K +   EKA V  +K L  EL
Sbjct: 1895 LTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGEL 1954

Query: 538  --SKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEEL 582
              +K E+    E +   E++  LVE    L   E     ++RK+ ++
Sbjct: 1955 DIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQV 2001



 Score = 77.0 bits (188), Expect = 7e-14
 Identities = 147/764 (19%), Positives = 329/764 (43%), Gaps = 91/764 (11%)

Query: 53   EQSLQSDYFKCNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPNS 112
            E++L     K ++EA+   +      KK E++ +        E  +L K    L  + N 
Sbjct: 1641 EETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAR--------EEEKLAKKGGKLAEVKNI 1692

Query: 113  IKRELEECVRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELAR 172
            + +++EE  +  + L+  E   +   +   E ++E L  K  +L +    L E++++LA 
Sbjct: 1693 LAQKVEELPQREQNLDWQE-KELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAE 1751

Query: 173  KHARFVLSLNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKERAEYLI 232
            +      +L    EK +     + +    +  ++E +A  K+ + E EE + ++R E LI
Sbjct: 1752 EEE----ALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKR-EQLI 1806

Query: 233  RKQELTAQINEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIAR 292
             K+   AQ  E    R +  ME   K K +   +  +++ K+        L+    ++A+
Sbjct: 1807 EKKMKLAQKRE----RWINSMEELTKNKMILYQKKNLAQEKKN-------LAQEKEKLAQ 1855

Query: 293  LHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHA 352
              E++ Y ++ ++  KK L  ++ KL  F     ++++    EK   + K ++L ET   
Sbjct: 1856 RKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKK 1915

Query: 353  ARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVD 412
                   L +K + LA++ K+ L+ E+     K+++  E         +K   L  KR+ 
Sbjct: 1916 LVQVEDSLAKKQEKLAQE-KMKLALEKAMVQGKKRLRGELDIAK---EEKALNLEMKRLA 1971

Query: 413  IKNME--EGLITL-----------QELQQATKTVYQQQIKILSANLERESQRCVITQWKM 459
             + M   EG  TL           +++ Q  + ++++++ +    L  E +   + + ++
Sbjct: 1972 EEKMRLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEI 2031

Query: 460  ACLRKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTEL 519
            A   K    +T   +  +Q    K+  A  + I+     S    +++  +  ++KLT   
Sbjct: 2032 A---KGKLEFTRGQRIFVQG-QRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLT--- 2084

Query: 520  KEEEKAFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKL 579
            ++E K  + +E++ M ++ +   +FVKE +++ E+ +        L + E ++ EKR +L
Sbjct: 2085 RDERK--LTQEEIKMTKMKR--ALFVKERRLSIEQSK--------LDIKEWDFSEKRSEL 2132

Query: 580  EELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETL 639
             +    +   R++  L N           R + N E+      ++ ++ESK  + H E +
Sbjct: 2133 TKDEKKLA--RKQRKLANK---------MRRMINKEE------KMTEEESKLARKHSEVI 2175

Query: 640  KNLENGFYINDQKADLLLLEN----------KKLKEYILYLKNNIEKYREGQEALMHTSN 689
             + E    I +++    L              K KE      + +E      E +    +
Sbjct: 2176 LDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLD 2235

Query: 690  DLSRQLIAQEAQYKDLWAEFQTTVKILVDNGEETLQDINNLTDKL-RERDEKMQHVSTWL 748
            +L +Q      + ++   E +   + + +  EE  ++      ++ +E +EK +      
Sbjct: 2236 ELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKK 2295

Query: 749  RGSLEGLRLLVEQESPMDLLSKQQLRALLVTSKEEKTCQLSDLV 792
            +  ++    + E++   +++S+++  +L    +EE++C L + V
Sbjct: 2296 KEEVQEKEEVFEEKE--EIMSEEETESLSDEEEEEESCSLEEEV 2337



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 135/675 (20%), Positives = 286/675 (42%), Gaps = 128/675 (18%)

Query: 76   VAVKKLEEM--RKATIDLLEIE-SMELNKLYYLLETLP---NSIKRELEECVRDARRLN- 128
            +  +K+EE+  R+  +D  E E + EL +L + +E L      + +E  + V + ++L  
Sbjct: 1692 ILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAE 1751

Query: 129  -----LFEINTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFVLSLNQ 183
                  ++   +    T+   E ELL ++   L ++ E + E++E L RK  + +    +
Sbjct: 1752 EEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMK 1811

Query: 184  TMEKKATTTVYINE-TYTKINL-KREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQI 241
              +K+      + E T  K+ L +++++A +KK + + +E + + +   L  K+ LT   
Sbjct: 1812 LAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSK 1871

Query: 242  NEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWE 301
             +    +    M      K L +++ K+++ KETV      L++   ++ ++ +S+   +
Sbjct: 1872 KQLVQVKNKLGMFN----KILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQ 1927

Query: 302  QEVSELKKDLAILEAKLCFFTDNKEKLD---DISNDEKNEFLNKIKQLVE---------- 348
            +++++ K  LA+ +A +      K++L    DI+ +EK   L ++K+L E          
Sbjct: 1928 EKLAQEKMKLALEKAMV----QGKKRLRGELDIAKEEKALNL-EMKRLAEEKMRLVEGKE 1982

Query: 349  TLHAARMEYKDLREKM---------KTLARQYKIVLSEE-------------EKAFLQKQ 386
            TL          + KM         + L+ + KI+L E+             +  F + Q
Sbjct: 1983 TLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQ 2042

Query: 387  KIHDENQKQLTFISQKEYFLSQKRVDIKN----MEEGLITLQELQQATKTVYQQQIK--- 439
            +I  + Q++L   S+K   L +KR  +      + + L  LQ+L +  + + Q++IK   
Sbjct: 2043 RIFVQGQRKLAKASRK---LIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTK 2099

Query: 440  ------ILSANLERESQRCVITQW--------------KMACLRKKHARWTAKIKAEIQA 479
                  +    L  E  +  I +W              K+A  ++K A    ++  + + 
Sbjct: 2100 MKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEK 2159

Query: 480  ITEKIQNAEVRRIELL----NETSFRQQEISGFVAQIEKLTTELK--------------- 520
            +TE+      +  E++     E    ++E+  F+ +  +   E K               
Sbjct: 2160 MTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDE 2219

Query: 521  -EEEKAFVNKEKMLMKELSKYEEIF-----------------VKETQINKEKEEELVEYL 562
             E E+ F  + + L+ EL K E +                  V+E +  +++EEE  E  
Sbjct: 2220 VESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQ 2279

Query: 563  PQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQ 622
             + +  E++ K+K +K EE+        ++E++++      T   S      E    E +
Sbjct: 2280 VEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEE---ETESLSDEEEEEESCSLEEE 2336

Query: 623  QLRDQESKKNKDHFE 637
              R++E  K +  F+
Sbjct: 2337 VDREKEILKKEKQFK 2351



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 105/559 (18%), Positives = 258/559 (46%), Gaps = 43/559 (7%)

Query: 113  IKRELEECVRDARRLNLFEINTIK--MRITRTENEIELLKKKITDLTKYNEALGEKQEEL 170
            + +E E+  ++ R+L   E    +  ++IT+ + E+   + K     +     GEK  + 
Sbjct: 1595 LAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQE 1654

Query: 171  ARKHARFVLSLNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKERAEY 230
            A K A+    L +  EK A     + +   K+   +  +A      Q+ EEL ++E+   
Sbjct: 1655 AEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILA------QKVEELPQREQ-NL 1707

Query: 231  LIRKQELTAQINEFENTREV---KRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHN 287
              +++EL  ++ E E   E    K  E  Q++ +L + + K+++ +E +      LS+  
Sbjct: 1708 DWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEE 1767

Query: 288  LEIARLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLV 347
             ++A+  E +   ++++++ K+ +   E +L    +   +       ++  ++N +++L 
Sbjct: 1768 TKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEELT 1827

Query: 348  ETLHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLS 407
            +       + K+L ++ K LA++ + +   +E     K+++   ++KQL  +  K    +
Sbjct: 1828 KN-KMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERL-THSKKQLVQVKNKLGMFN 1885

Query: 408  Q--KRVDIKNMEEGLITLQELQQATKTVYQQQIKILSANLERESQRCVITQWKMACLRKK 465
            +   +V+ K  +E    +++ ++  +T  ++++  +  +L ++ ++    + K+A L K 
Sbjct: 1886 KILAQVEEKLTQEKETVIKKKEKLAET--EKKLVQVEDSLAKKQEKLAQEKMKLA-LEKA 1942

Query: 466  HARWTAKIKAEIQ-AITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEK 524
              +   +++ E+  A  EK  N E++R   L E   R  E    +++ E  T E   + K
Sbjct: 1943 MVQGKKRLRGELDIAKEEKALNLEMKR---LAEEKMRLVEGKETLSKGE--TPETSRQRK 1997

Query: 525  AFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSN 584
                ++++  ++LS  E+I + E +I   +E E+ +   +    ++ + + +RKL + S 
Sbjct: 1998 MTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASR 2057

Query: 585  IITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNLEN 644
             +  +R+                S+  + +  + + LQ+L   E K  ++  +  K ++ 
Sbjct: 2058 KLIKKRE--------------SLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTK-MKR 2102

Query: 645  GFYINDQKADLLLLENKKL 663
              ++ +++   L +E  KL
Sbjct: 2103 ALFVKERR---LSIEQSKL 2118



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 104/551 (18%), Positives = 240/551 (43%), Gaps = 88/551 (15%)

Query: 72   KDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEECVRDARRLNLFE 131
            K I    K L + +K      E  +     L Y  E L +S K    + V+   +L +F 
Sbjct: 1830 KMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKK----QLVQVKNKLGMFN 1885

Query: 132  --INTIKMRITRTENEIELLKKKITD----LTKYNEALGEKQEELARKHARFVLSLNQTM 185
              +  ++ ++T+ +  +   K+K+ +    L +  ++L +KQE+LA++  +  L      
Sbjct: 1886 KILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQ 1945

Query: 186  EKKATT-TVYINETYTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQINE- 243
             KK     + I +    +NL+ + +A +K  + E +E + K       R++++T    E 
Sbjct: 1946 GKKRLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQEL 2005

Query: 244  FENTREVKR-----------MET-----------------YQKKKELDKLQTKMSKIKET 275
            FE    ++            ME                   Q +++L K   K+ K +E+
Sbjct: 2006 FERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRES 2065

Query: 276  VTVSAAVLSDHNLEIARLHESIRYWEQE---VSELKKDLAILEAKLCFFT--------DN 324
            ++   A L+     + +L    R   QE   ++++K+ L + E +L            D 
Sbjct: 2066 LSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEWDF 2125

Query: 325  KEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQY-KIVLSEEEKAFL 383
             EK  +++ DEK +   K ++L   +     + + + E+   LAR++ +++L +EE+  +
Sbjct: 2126 SEKRSELTKDEK-KLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGI 2184

Query: 384  QKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSA 443
            +++++       + F+ ++     + +   K  E+    + E++  ++  + ++++ L  
Sbjct: 2185 EEEEV-------IPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVE--SEEHFSEEMESLLD 2235

Query: 444  NLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQ 503
             LE++     ++  +     ++  R   +++ E +   E+ +  E +++E   E   +++
Sbjct: 2236 ELEKQES---LSSEEEEEREEEEEREEEEVREEEEERKEE-EEGEEKQVEKEEEEKKKKK 2291

Query: 504  EISGFVAQIEKLTTELKEEEKAFVNKEKMLMKE--------------LSKYEEIFVKETQ 549
            +        EK   E++E+E+ F  KE+++ +E               S  EE+  ++  
Sbjct: 2292 K--------EKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDREKEI 2343

Query: 550  INKEKEEELVE 560
            + KEK+ +L E
Sbjct: 2344 LKKEKQFKLQE 2354



 Score = 40.0 bits (92), Expect = 0.009
 Identities = 66/331 (19%), Positives = 130/331 (39%), Gaps = 76/331 (22%)

Query: 34   PSTLGSSVAVEALEQLFVVEQSLQSDYFKCNEEAKIFLKDIAVAVKKLEEMRKATIDL-- 91
            P T       +  ++LF  + SL+      +E+  + +++  +A  KLE  R   I +  
Sbjct: 1990 PETSRQRKMTQVEQELFERKLSLEEKIL-LHEDRILAMEESEIAKGKLEFTRGQRIFVQG 2048

Query: 92   ---LEIESMELNKLYYLLETLP---NSIKRELEECVRDARRLNLFEINTIKMR------- 138
               L   S +L K    L   P   N I + L++  RD R+L   EI   KM+       
Sbjct: 2049 QRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKE 2108

Query: 139  -----------------------ITRTENEIELLKKKITD----LTKYNEALGEKQEELA 171
                                   +T+ E ++   ++K+ +    +    E + E++ +LA
Sbjct: 2109 RRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLA 2168

Query: 172  RKHARFVLS---------------LNQTMEK----------KATTTVYINETYTKINLKR 206
            RKH+  +L                L +   K          K   +  ++E  ++ +   
Sbjct: 2169 RKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSE 2228

Query: 207  E------DIALQKKCIQEAEELMEKE--RAEYLIRKQELTAQINEFENTREVKRMETYQK 258
            E      ++  Q+    E EE  E+E  R E  +R++E   +  E    ++V++ E  +K
Sbjct: 2229 EMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKK 2288

Query: 259  KKELDKLQTKMSKIKETVTVSAAVLSDHNLE 289
            KK+ +K + ++ + +E       ++S+   E
Sbjct: 2289 KKKKEKKKEEVQEKEEVFEEKEEIMSEEETE 2319



 Score = 30.8 bits (68), Expect = 5.4
 Identities = 30/128 (23%), Positives = 58/128 (45%), Gaps = 4/128 (3%)

Query: 144  NEIELLKKKITDLTKYNEALGEKQEELARKHARFVLSLNQTMEKKATTTVYINETYTKIN 203
            +E+E  +   ++  +  E   E++EE  R+         +  E+K        +   K  
Sbjct: 2235 DELEKQESLSSEEEEEREEEEEREEEEVREEEE-ERKEEEEGEEKQVEKEEEEKKKKKKE 2293

Query: 204  LKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVKRMETYQKKKELD 263
             K+E++  +++  +E EE+M +E  E L  ++E     +  E   EV R +   KK++  
Sbjct: 2294 KKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEE---EVDREKEILKKEKQF 2350

Query: 264  KLQTKMSK 271
            KLQ +  K
Sbjct: 2351 KLQEQRRK 2358


>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo
           sapiens]
          Length = 1116

 Score = 91.7 bits (226), Expect = 3e-18
 Identities = 160/727 (22%), Positives = 290/727 (39%), Gaps = 128/727 (17%)

Query: 71  LKDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEECVRDARRLNLF 130
           L+   ++ K  EE  + T  L E E M ++ L  LLE      ++E E  +        F
Sbjct: 316 LQSKGLSAKATEEDHERTRRLAEAE-MHVHHLESLLE------QKEKENSMLREEMHRRF 368

Query: 131 EINTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFVLSLNQTMEKKAT 190
           E      +    +  IE+   KI+ + +    L + +EE+    +   LS  +  E+   
Sbjct: 369 ENAPDSAKTKALQTVIEMKDSKISSMER---GLRDLEEEIQMLKSNGALSTEEREEEMKQ 425

Query: 191 TTVYINETYTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREV 250
             VY   +++K         ++ K  Q  EEL  KE            AQ  E +     
Sbjct: 426 MEVY--RSHSKF--------MKNKVEQLKEELSSKE------------AQWEELKKKAAG 463

Query: 251 KRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKD 310
            + E  Q K+EL +  T++  ++  +       SD    I  L ES+   EQ  + L+ +
Sbjct: 464 LQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTE 523

Query: 311 LAI----LEAKLCFFTDNKEKLDDISND--------------------EKNEFLNKIKQL 346
           +      LE K        +++ D++ +                    + N    KI+ L
Sbjct: 524 VDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENL 583

Query: 347 VETLHAARMEYKDLREKMKTLARQ----------YKIVLSEEEKAF--LQKQKIHDENQK 394
            E L     +   L+E++K+L              +  L+E+E+    L++Q+  DE +K
Sbjct: 584 QEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREK 643

Query: 395 QLTFISQKEYF------LSQKRVDIKNMEEGLITLQELQQATKT---VYQQQIKILSANL 445
           Q    + K+        +S  + D+   E  L+ L+E   +  +       ++K L   L
Sbjct: 644 QEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIAL 703

Query: 446 ERESQRCVITQWKMACLRKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEI 505
           E++ + C+    KM    KK      + +A  + ++++IQ+ E       +E+S  Q E+
Sbjct: 704 EQKKEECL----KMESQLKKAHEAALEARASPE-MSDRIQHLEREITRYKDESSKAQAEV 758

Query: 506 SGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYL--- 562
              +  ++++  E  +++K     E+ +  +  K   +  KE Q+ K+K  +++E     
Sbjct: 759 DRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKE-QVEKKKSAQMLEEARRR 817

Query: 563 -PQLQVAEQEYKEKRRK----LEELSNI------ITAQR-----QEEDLLNNHIFLFTRD 606
              L  + Q+ ++  RK    +EEL         ITA+R     QEE    N      + 
Sbjct: 818 EDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTN----AEKQ 873

Query: 607 FSRYISNMEDVKQEL-----------QQLRDQESKKNKDHFETLKNLENGFYINDQKADL 655
               +  ME VKQEL           Q L ++E+       E  K+LE    +  Q+A L
Sbjct: 874 VEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMK-QEALL 932

Query: 656 LLLENKKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTTVKI 715
             +  K     +L L ++ +K +E   AL    + L +QL  Q           Q  +K+
Sbjct: 933 AAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQT----------QNRMKL 982

Query: 716 LVDNGEE 722
           + DN E+
Sbjct: 983 MADNYED 989



 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 135/676 (19%), Positives = 279/676 (41%), Gaps = 132/676 (19%)

Query: 181 LNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQ 240
           L+   E++A     + +T  ++ L+   I  QK+ +   +E ++K     +++ + L+A+
Sbjct: 270 LHAEHERQAKELFLLRKTLEEMELR---IETQKQTLNARDESIKKLLE--MLQSKGLSAK 324

Query: 241 INE--FENTREVKRMETY---------QKKKELDKLQTKMSKIKETVTVSA------AVL 283
             E   E TR +   E +         QK+KE   L+ +M +  E    SA       V+
Sbjct: 325 ATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVI 384

Query: 284 SDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKI 343
              + +I+ +   +R  E+E+  LK + A+   +     + + K  ++         NK+
Sbjct: 385 EMKDSKISSMERGLRDLEEEIQMLKSNGALSTEE----REEEMKQMEVYRSHSKFMKNKV 440

Query: 344 KQLVETLHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKE 403
           +QL E L +   ++++L++K   L  +                            I Q +
Sbjct: 441 EQLKEELSSKEAQWEELKKKAAGLQAE----------------------------IGQVK 472

Query: 404 YFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSANLERESQRCVITQWKMACLR 463
             LS+K  ++  ++  L TL      +K    Q I++L  +L  + QR  I Q ++  LR
Sbjct: 473 QELSRKDTELLALQTKLETLTNQFSDSK----QHIEVLKESLTAKEQRAAILQTEVDALR 528

Query: 464 ----KKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTEL 519
               +K      K K +IQ + E+         +L +    ++++++    +IE L  +L
Sbjct: 529 LRLEEKETMLNKKTK-QIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQL 587

Query: 520 KEEEK---AFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKR 576
           +++EK   +   + K L  + +  +       +   EKE  +       ++ EQ  +++R
Sbjct: 588 RDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIE------RLKEQRDRDER 641

Query: 577 RKLEELSNIITAQRQEEDL--LNNHIFLFTRDFSRYISNMEDVKQELQQLRDQESKKNKD 634
            K EE+ N       ++DL  L   + L   D S   +++ D+K+    L     KK+  
Sbjct: 642 EKQEEIDNY------KKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDS- 694

Query: 635 HFETLKNLENGFYINDQKADLLLLENK---------------KLKEYILYLKNNIEKYRE 679
               LK LE    +  +K + L +E++               ++ + I +L+  I +Y++
Sbjct: 695 ---RLKTLE--IALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKD 749

Query: 680 GQ--------------EALMHTSNDLSRQLIAQEAQYKD-------LWAEFQTTVKILVD 718
                           + + +  ND  +++   E Q KD       L  + Q   K    
Sbjct: 750 ESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQ 809

Query: 719 NGEETLQDINNLTDKL-------RERDEKMQHVSTWLRGSLE---GLRLLVEQESPMDLL 768
             EE  +  +NL D         R++D++++ +   LR S++      +++ QE      
Sbjct: 810 MLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTN 869

Query: 769 SKQQLRALLVTSKEEK 784
           +++Q+  LL+  ++ K
Sbjct: 870 AEKQVEELLMAMEKVK 885



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 119/540 (22%), Positives = 221/540 (40%), Gaps = 77/540 (14%)

Query: 278 VSAAVLSDHNLEIAR------LHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDI 331
           VS A    H+L  AR      L   ++   +E   L+KD+ + E+KL             
Sbjct: 133 VSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKL------------- 179

Query: 332 SNDEKNEFLNKIKQLVET-LHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHD 390
                +  +N IK      L   R   KD   K+     QY++V  E +   +  Q + D
Sbjct: 180 -----SSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQD 234

Query: 391 E--NQKQLTFISQKEYFLSQKRVDIKNM-EEGLITL--------QELQQATKTVYQQQIK 439
           E   Q+ L  + Q++         +  + EE    L        +EL    KT+ + +++
Sbjct: 235 ELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELR 294

Query: 440 I----LSANLERESQRCVITQWKMACLRKK-----HARWTAKIKAEIQA-ITEKIQNAEV 489
           I     + N   ES + ++   +   L  K     H R     +AE+     E +   + 
Sbjct: 295 IETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKE 354

Query: 490 RRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSKYEEIFVKETQ 549
           +   +L E   R+ E +   A+ + L T ++ ++    + E+ L ++L +  ++      
Sbjct: 355 KENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGL-RDLEEEIQMLKSNGA 413

Query: 550 INKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITA-QRQEEDL------LNNHIFL 602
           ++ E+ E   E + Q++V     K  + K+E+L   +++ + Q E+L      L   I  
Sbjct: 414 LSTEERE---EEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQ 470

Query: 603 FTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNLENGFYINDQKADLLLLENKK 662
             ++ SR  + +  ++ +L+ L +Q S  +K H E LK         +Q+A +L  E   
Sbjct: 471 VKQELSRKDTELLALQTKLETLTNQFS-DSKQHIEVLK---ESLTAKEQRAAILQTEVDA 526

Query: 663 L------KEYILYLK-NNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTTVKI 715
           L      KE +L  K   I+   E +       +DL   L  +E +   L  +       
Sbjct: 527 LRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKK------- 579

Query: 716 LVDNGEETLQDINNLTDKLRERDEKMQHVSTWLRGSLEGL-RLLVEQESPMDLLSKQQLR 774
            ++N +E L+D       L+ER + +Q  +T    +L  L   L E+E  ++ L +Q+ R
Sbjct: 580 -IENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDR 638


>gi|118498356 kinectin 1 isoform a [Homo sapiens]
          Length = 1357

 Score = 90.5 bits (223), Expect = 6e-18
 Identities = 157/791 (19%), Positives = 327/791 (41%), Gaps = 146/791 (18%)

Query: 44   EALEQLFVVEQSLQSDYFK--CNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNK 101
            + LEQ   ++  +Q  + +      A +  +++   + + ++  K T D L  E   L  
Sbjct: 573  DILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTS 632

Query: 102  LYYLLETLPNS---IKRELE--ECVRDARRLNLFEINTIKMRITRTENEIELLKKKITDL 156
                L+ + N    +K E++  + + + +     E+  ++  +   +++I LL++++   
Sbjct: 633  KEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQL--- 689

Query: 157  TKYNEALGEKQEELARKHARFVLSLNQTMEKKATTTVYINETYTKINLKREDIALQKKCI 216
                      Q E++ K   F +  +Q   K   + V   +T       ++ +   +KCI
Sbjct: 690  ----------QHEISNKMEEFKILNDQN--KALKSEVQKLQTLVSEQPNKDVVEQMEKCI 737

Query: 217  QE-------AEELMEKERAEYLIRKQELTAQINEFEN-TREVKRMETYQKKK-------- 260
            QE        EEL+E    +   +++EL A   E  + T+EV+ ++  Q  +        
Sbjct: 738  QEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVE 797

Query: 261  ELDK-LQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLC 319
            EL K +  K  KIK    +  A L    L++A   ++++  +QE+  LK+++  ++ +  
Sbjct: 798  ELKKVIHEKDGKIKSVEELLEAEL----LKVANKEKTVQDLKQEIKALKEEIGNVQLEKA 853

Query: 320  FFTDNKEKLDDISN--DEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLSE 377
                   K+ ++ N    K E +N +K ++E       + KDL    K L    + +  E
Sbjct: 854  QQLSITSKVQELQNLLKGKEEQMNTMKAVLEE------KEKDLANTGKWL----QDLQEE 903

Query: 378  EEKAFLQKQKIHDENQKQLTFISQ---KEYFLSQKRVDIKNMEEGLITLQELQQATKTVY 434
             E      Q++   N K+ +  SQ    E  L +K  ++K +E  ++  +E   ++KT  
Sbjct: 904  NESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLE-AMLKERESDLSSKTQL 962

Query: 435  QQQI----KILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAITEKIQNAEVR 490
             Q +    K+  + +E+  Q+     ++ A     H                        
Sbjct: 963  LQDVQDENKLFKSQIEQLKQQ----NYQQASSFPPHE----------------------- 995

Query: 491  RIELLNETSFRQQEISGFVAQIEKLTTELKEEEK--------------AFVNKEKMLMKE 536
              ELL   S R++EISG   +++ L   ++ + K              A  + EKML  +
Sbjct: 996  --ELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDK 1053

Query: 537  LSKYEEIFVKETQ-INKEKEEELVEYLPQLQVAEQ--------EYKEKRRKL------EE 581
            ++K  +   ++ + +  E +E L +  P++ V            +++K ++        E
Sbjct: 1054 VNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSE 1113

Query: 582  LSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQQLRDQESKKNK----DHFE 637
               ++  + +E D ++  + L    +   ++  E + Q+LQ+  +QE  K K    +  +
Sbjct: 1114 EVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHK 1173

Query: 638  TLKNLENGFYINDQKADLLLLENKKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIA 697
            T+K +++ F  ++Q+ + L  ENK ++        N+ + RE  E  +  +       + 
Sbjct: 1174 TIKQMQSSFTSSEQELERLRSENKDIE--------NLRREREHLEMELEKAEMERSTYVT 1225

Query: 698  QEAQYKDLWAEFQTTVKILVDNGEETLQ----------DINNLTDKLRERDEKMQHVSTW 747
            +  + KDL  E Q   K L D+  E ++           +N    KLR    + Q V+  
Sbjct: 1226 EVRELKDLLTELQ---KKLDDSYSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKVAGD 1282

Query: 748  LRGSLEGLRLL 758
            L  + + L L+
Sbjct: 1283 LHKAQQSLELI 1293



 Score = 73.9 bits (180), Expect = 6e-13
 Identities = 144/714 (20%), Positives = 301/714 (42%), Gaps = 109/714 (15%)

Query: 65  EEAKIFLKDIAVAVKKL---EEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEECV 121
           E A++  KD  +++K +   E+     +DLL+ +S  +       + L  S K EL   +
Sbjct: 278 ENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQ------DALKKSSKGELTTLI 331

Query: 122 RDARRLNLFEINTIKMRITRTENEIELLKKKITD--------LTKYNEALGEKQEELARK 173
              +  +   +  +K     T++  + L +++          +T+  + +G  ++E    
Sbjct: 332 HQLQEKDKL-LAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVF 390

Query: 174 HARFVLSLNQTMEKKATTTVYINETYTKI-NLKREDIALQKKCIQEAEELMEKERAEYLI 232
             +  +S  +T + +        +   +I +LK+E+  L+        +L  K+ AE   
Sbjct: 391 QNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNK 450

Query: 233 RKQELTAQINEF-ENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIA 291
            +Q+    +NE  E T ++++ E  +K  E    Q K+                      
Sbjct: 451 LRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKV---------------------- 488

Query: 292 RLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLH 351
           +L E+ R WE+  S ++K  A  EA        ++ L      ++NE  +   +L +TL 
Sbjct: 489 QLQEAERRWEEVQSYIRKRTAEHEAA-------QQDLQSKFVAKENEVQSLHSKLTDTL- 540

Query: 352 AARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRV 411
              +  + L +++  L    +  +++EE   +Q Q I ++N+      +Q + F SQ   
Sbjct: 541 ---VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNE---ALKAQIQQFHSQ--- 591

Query: 412 DIKNMEEGLITLQELQQATKTVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTA 471
            I       +  +EL +       +QIK    +L  E  R    + ++  ++  +    A
Sbjct: 592 -IAAQTSASVLAEELHKVI-AEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKA 649

Query: 472 KIKAEIQAITEKIQNAEVRRIELLNETSF-RQQEISGFVAQIEKLTTELKEEEKAFVNKE 530
           +++ ++QA+  + Q A    +E + ++ + +  +I     Q++   +   EE K   ++ 
Sbjct: 650 EVQ-KLQALANE-QAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQN 707

Query: 531 KMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEEL--SNIITA 588
           K L  E+ K       +T ++++  +++VE   Q++   QE  EK + +EEL  + +I  
Sbjct: 708 KALKSEVQKL------QTLVSEQPNKDVVE---QMEKCIQEKDEKLKTVEELLETGLIQV 758

Query: 589 QRQEEDLLNNHIFLFTRDFSRYISNME----------DVKQELQQLRDQESKKNKDHFET 638
             +EE+L  N I       ++ + +++           + +EL+++  ++  K K   E 
Sbjct: 759 ATKEEEL--NAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEEL 816

Query: 639 LKNLENGFYINDQKADLLLLENKK-----LKEYILYLK---NNIEKYREGQEALMHTSND 690
           L            +A+LL + NK+     LK+ I  LK    N++  +  Q ++     +
Sbjct: 817 L------------EAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQE 864

Query: 691 LSRQLIAQEAQYKDLWAEFQTTVKILVDNGEETLQDINNLTDKLRER-DEKMQH 743
           L   L  +E Q   + A  +   K L + G + LQD+    + L+    E  QH
Sbjct: 865 LQNLLKGKEEQMNTMKAVLEEKEKDLANTG-KWLQDLQEENESLKAHVQEVAQH 917



 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 117/612 (19%), Positives = 253/612 (41%), Gaps = 90/612 (14%)

Query: 52   VEQSLQSDYFKCNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPN 111
            VE+ L+++  K   + K  ++D+   +K L+E         EI +++L K   L  T   
Sbjct: 813  VEELLEAELLKVANKEKT-VQDLKQEIKALKE---------EIGNVQLEKAQQLSIT--- 859

Query: 112  SIKRELEECVRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELA 171
            S  +EL+  ++        ++NT+K  +   E ++    K + DL + NE+L    +E+A
Sbjct: 860  SKVQELQNLLKGKEE----QMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVA 915

Query: 172  RKHARFVLSLNQTMEKKATTTVYINE---TYTKINLKREDIALQKKCIQEAEELMEKERA 228
            + + +   S +Q  E +       NE       +  +  D++ + + +Q+ ++  +  ++
Sbjct: 916  QHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKS 975

Query: 229  EYLIRKQELTAQINEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNL 288
            +    KQ+   Q + F    E+ ++ + +++KE+  L  ++  +K+ V       +D   
Sbjct: 976  QIEQLKQQNYQQASSFPPHEELLKVIS-EREKEISGLWNELDSLKDAVEHQRKKNND--- 1031

Query: 289  EIARLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLV- 347
                L E  + WE  +  L     +L+ K+   +  +++  +    E  E L K+   V 
Sbjct: 1032 ----LRE--KNWE-AMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVS 1084

Query: 348  --------ETLHAARMEYKDL------REKMKTLARQYKIVLSEEEKAFLQKQKIHDENQ 393
                    E LH    + K+        E++K L  ++K+  ++E    LQ      E +
Sbjct: 1085 VPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVL--EHKLKEADEMHTLLQL-----ECE 1137

Query: 394  KQLTFISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSANLERESQRCV 453
            K  + +++ E  L + +  ++  E       ++ ++ KT+ Q Q    S+  E E     
Sbjct: 1138 KYKSVLAETEGILQKLQRSVEQEENKWKV--KVDESHKTIKQMQSSFTSSEQELE----- 1190

Query: 454  ITQWKMACLRKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIE 513
                                   +++  + I+N    R  L  E    + E S +V ++ 
Sbjct: 1191 ----------------------RLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVR 1228

Query: 514  KLTTELKEEEKAFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYK 573
            +L   L E +K     +    + + + EE+ + + Q+N+   +   E   + +VA   +K
Sbjct: 1229 ELKDLLTELQKKL---DDSYSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKVAGDLHK 1285

Query: 574  EKRRKLEELSNIITAQRQEEDLLNNHIFLFTRD-----FSRYISNMEDVKQELQQLRDQE 628
             ++      S I+ A      + N+ +   T        S  ++      Q+L Q  +Q+
Sbjct: 1286 AQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQ 1345

Query: 629  SKKNKDHFETLK 640
              K K+H++ L+
Sbjct: 1346 LTKEKEHYQVLE 1357


>gi|33620775 kinectin 1 isoform a [Homo sapiens]
          Length = 1357

 Score = 90.5 bits (223), Expect = 6e-18
 Identities = 157/791 (19%), Positives = 327/791 (41%), Gaps = 146/791 (18%)

Query: 44   EALEQLFVVEQSLQSDYFK--CNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNK 101
            + LEQ   ++  +Q  + +      A +  +++   + + ++  K T D L  E   L  
Sbjct: 573  DILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTS 632

Query: 102  LYYLLETLPNS---IKRELE--ECVRDARRLNLFEINTIKMRITRTENEIELLKKKITDL 156
                L+ + N    +K E++  + + + +     E+  ++  +   +++I LL++++   
Sbjct: 633  KEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQL--- 689

Query: 157  TKYNEALGEKQEELARKHARFVLSLNQTMEKKATTTVYINETYTKINLKREDIALQKKCI 216
                      Q E++ K   F +  +Q   K   + V   +T       ++ +   +KCI
Sbjct: 690  ----------QHEISNKMEEFKILNDQN--KALKSEVQKLQTLVSEQPNKDVVEQMEKCI 737

Query: 217  QE-------AEELMEKERAEYLIRKQELTAQINEFEN-TREVKRMETYQKKK-------- 260
            QE        EEL+E    +   +++EL A   E  + T+EV+ ++  Q  +        
Sbjct: 738  QEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVE 797

Query: 261  ELDK-LQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLC 319
            EL K +  K  KIK    +  A L    L++A   ++++  +QE+  LK+++  ++ +  
Sbjct: 798  ELKKVIHEKDGKIKSVEELLEAEL----LKVANKEKTVQDLKQEIKALKEEIGNVQLEKA 853

Query: 320  FFTDNKEKLDDISN--DEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLSE 377
                   K+ ++ N    K E +N +K ++E       + KDL    K L    + +  E
Sbjct: 854  QQLSITSKVQELQNLLKGKEEQMNTMKAVLEE------KEKDLANTGKWL----QDLQEE 903

Query: 378  EEKAFLQKQKIHDENQKQLTFISQ---KEYFLSQKRVDIKNMEEGLITLQELQQATKTVY 434
             E      Q++   N K+ +  SQ    E  L +K  ++K +E  ++  +E   ++KT  
Sbjct: 904  NESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLE-AMLKERESDLSSKTQL 962

Query: 435  QQQI----KILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAITEKIQNAEVR 490
             Q +    K+  + +E+  Q+     ++ A     H                        
Sbjct: 963  LQDVQDENKLFKSQIEQLKQQ----NYQQASSFPPHE----------------------- 995

Query: 491  RIELLNETSFRQQEISGFVAQIEKLTTELKEEEK--------------AFVNKEKMLMKE 536
              ELL   S R++EISG   +++ L   ++ + K              A  + EKML  +
Sbjct: 996  --ELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDK 1053

Query: 537  LSKYEEIFVKETQ-INKEKEEELVEYLPQLQVAEQ--------EYKEKRRKL------EE 581
            ++K  +   ++ + +  E +E L +  P++ V            +++K ++        E
Sbjct: 1054 VNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSE 1113

Query: 582  LSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQQLRDQESKKNK----DHFE 637
               ++  + +E D ++  + L    +   ++  E + Q+LQ+  +QE  K K    +  +
Sbjct: 1114 EVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHK 1173

Query: 638  TLKNLENGFYINDQKADLLLLENKKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIA 697
            T+K +++ F  ++Q+ + L  ENK ++        N+ + RE  E  +  +       + 
Sbjct: 1174 TIKQMQSSFTSSEQELERLRSENKDIE--------NLRREREHLEMELEKAEMERSTYVT 1225

Query: 698  QEAQYKDLWAEFQTTVKILVDNGEETLQ----------DINNLTDKLRERDEKMQHVSTW 747
            +  + KDL  E Q   K L D+  E ++           +N    KLR    + Q V+  
Sbjct: 1226 EVRELKDLLTELQ---KKLDDSYSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKVAGD 1282

Query: 748  LRGSLEGLRLL 758
            L  + + L L+
Sbjct: 1283 LHKAQQSLELI 1293



 Score = 73.9 bits (180), Expect = 6e-13
 Identities = 144/714 (20%), Positives = 301/714 (42%), Gaps = 109/714 (15%)

Query: 65  EEAKIFLKDIAVAVKKL---EEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEECV 121
           E A++  KD  +++K +   E+     +DLL+ +S  +       + L  S K EL   +
Sbjct: 278 ENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQ------DALKKSSKGELTTLI 331

Query: 122 RDARRLNLFEINTIKMRITRTENEIELLKKKITD--------LTKYNEALGEKQEELARK 173
              +  +   +  +K     T++  + L +++          +T+  + +G  ++E    
Sbjct: 332 HQLQEKDKL-LAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVF 390

Query: 174 HARFVLSLNQTMEKKATTTVYINETYTKI-NLKREDIALQKKCIQEAEELMEKERAEYLI 232
             +  +S  +T + +        +   +I +LK+E+  L+        +L  K+ AE   
Sbjct: 391 QNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNK 450

Query: 233 RKQELTAQINEF-ENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIA 291
            +Q+    +NE  E T ++++ E  +K  E    Q K+                      
Sbjct: 451 LRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKV---------------------- 488

Query: 292 RLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLH 351
           +L E+ R WE+  S ++K  A  EA        ++ L      ++NE  +   +L +TL 
Sbjct: 489 QLQEAERRWEEVQSYIRKRTAEHEAA-------QQDLQSKFVAKENEVQSLHSKLTDTL- 540

Query: 352 AARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRV 411
              +  + L +++  L    +  +++EE   +Q Q I ++N+      +Q + F SQ   
Sbjct: 541 ---VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNE---ALKAQIQQFHSQ--- 591

Query: 412 DIKNMEEGLITLQELQQATKTVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTA 471
            I       +  +EL +       +QIK    +L  E  R    + ++  ++  +    A
Sbjct: 592 -IAAQTSASVLAEELHKVI-AEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKA 649

Query: 472 KIKAEIQAITEKIQNAEVRRIELLNETSF-RQQEISGFVAQIEKLTTELKEEEKAFVNKE 530
           +++ ++QA+  + Q A    +E + ++ + +  +I     Q++   +   EE K   ++ 
Sbjct: 650 EVQ-KLQALANE-QAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQN 707

Query: 531 KMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEEL--SNIITA 588
           K L  E+ K       +T ++++  +++VE   Q++   QE  EK + +EEL  + +I  
Sbjct: 708 KALKSEVQKL------QTLVSEQPNKDVVE---QMEKCIQEKDEKLKTVEELLETGLIQV 758

Query: 589 QRQEEDLLNNHIFLFTRDFSRYISNME----------DVKQELQQLRDQESKKNKDHFET 638
             +EE+L  N I       ++ + +++           + +EL+++  ++  K K   E 
Sbjct: 759 ATKEEEL--NAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEEL 816

Query: 639 LKNLENGFYINDQKADLLLLENKK-----LKEYILYLK---NNIEKYREGQEALMHTSND 690
           L            +A+LL + NK+     LK+ I  LK    N++  +  Q ++     +
Sbjct: 817 L------------EAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQE 864

Query: 691 LSRQLIAQEAQYKDLWAEFQTTVKILVDNGEETLQDINNLTDKLRER-DEKMQH 743
           L   L  +E Q   + A  +   K L + G + LQD+    + L+    E  QH
Sbjct: 865 LQNLLKGKEEQMNTMKAVLEEKEKDLANTG-KWLQDLQEENESLKAHVQEVAQH 917



 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 117/612 (19%), Positives = 253/612 (41%), Gaps = 90/612 (14%)

Query: 52   VEQSLQSDYFKCNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPN 111
            VE+ L+++  K   + K  ++D+   +K L+E         EI +++L K   L  T   
Sbjct: 813  VEELLEAELLKVANKEKT-VQDLKQEIKALKE---------EIGNVQLEKAQQLSIT--- 859

Query: 112  SIKRELEECVRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELA 171
            S  +EL+  ++        ++NT+K  +   E ++    K + DL + NE+L    +E+A
Sbjct: 860  SKVQELQNLLKGKEE----QMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVA 915

Query: 172  RKHARFVLSLNQTMEKKATTTVYINE---TYTKINLKREDIALQKKCIQEAEELMEKERA 228
            + + +   S +Q  E +       NE       +  +  D++ + + +Q+ ++  +  ++
Sbjct: 916  QHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKS 975

Query: 229  EYLIRKQELTAQINEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNL 288
            +    KQ+   Q + F    E+ ++ + +++KE+  L  ++  +K+ V       +D   
Sbjct: 976  QIEQLKQQNYQQASSFPPHEELLKVIS-EREKEISGLWNELDSLKDAVEHQRKKNND--- 1031

Query: 289  EIARLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLV- 347
                L E  + WE  +  L     +L+ K+   +  +++  +    E  E L K+   V 
Sbjct: 1032 ----LRE--KNWE-AMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVS 1084

Query: 348  --------ETLHAARMEYKDL------REKMKTLARQYKIVLSEEEKAFLQKQKIHDENQ 393
                    E LH    + K+        E++K L  ++K+  ++E    LQ      E +
Sbjct: 1085 VPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVL--EHKLKEADEMHTLLQL-----ECE 1137

Query: 394  KQLTFISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSANLERESQRCV 453
            K  + +++ E  L + +  ++  E       ++ ++ KT+ Q Q    S+  E E     
Sbjct: 1138 KYKSVLAETEGILQKLQRSVEQEENKWKV--KVDESHKTIKQMQSSFTSSEQELE----- 1190

Query: 454  ITQWKMACLRKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIE 513
                                   +++  + I+N    R  L  E    + E S +V ++ 
Sbjct: 1191 ----------------------RLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVR 1228

Query: 514  KLTTELKEEEKAFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYK 573
            +L   L E +K     +    + + + EE+ + + Q+N+   +   E   + +VA   +K
Sbjct: 1229 ELKDLLTELQKKL---DDSYSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKVAGDLHK 1285

Query: 574  EKRRKLEELSNIITAQRQEEDLLNNHIFLFTRD-----FSRYISNMEDVKQELQQLRDQE 628
             ++      S I+ A      + N+ +   T        S  ++      Q+L Q  +Q+
Sbjct: 1286 AQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQ 1345

Query: 629  SKKNKDHFETLK 640
              K K+H++ L+
Sbjct: 1346 LTKEKEHYQVLE 1357


>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
          Length = 1417

 Score = 90.5 bits (223), Expect = 6e-18
 Identities = 133/643 (20%), Positives = 279/643 (43%), Gaps = 51/643 (7%)

Query: 92   LEIESMELNKLYYLLETLPNSIKRELEECVRDARRLNLFEINTIKMRITRTENEIELLKK 151
            LE E ME N+    LET  N+   ++      A++++L +   ++ +I R E ++E   +
Sbjct: 723  LEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQ 782

Query: 152  KITDLTKYNEALGEKQEELARKHARFVLSLNQTMEKKATTTVYINETYTKINLKREDI-- 209
            +  +  K    L  +Q+ + ++H   + SL++ + +             K N+K+++   
Sbjct: 783  QFKEQEKTMSML--QQDIICKQH--HLESLDRLLTES-------KGEMKKENMKKDEALK 831

Query: 210  ALQKKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVKRMETYQKKKELDKLQTKM 269
            ALQ +  +E  ++ + + A   I K+EL   +N+ E  +E    +  +K +E+  LQ ++
Sbjct: 832  ALQNQVSEETIKVRQLDSA-LEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKEL 890

Query: 270  SKIKE---TVTVSAAVLSDHNLEIARL---HESIRYWEQEVSELKKDLAILEAKLCFFTD 323
             KIK      T    V+  H L+  +     E+IR  E E ++ K +  +          
Sbjct: 891  -KIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQV---------- 939

Query: 324  NKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTL---ARQYKIVLSE--E 378
               KL+     ++     K++++ E   +A  E    R+K+  L   ARQ KI + +  E
Sbjct: 940  --SKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKE 997

Query: 379  EKAFLQKQKIH--DENQKQLTFISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQQ 436
            E + ++K+ +H   + + +   +SQ +  L Q + +++     +  L++LQ +T+T   +
Sbjct: 998  ELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTE 1057

Query: 437  QIK---ILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAITEKIQNAEVRRIE 493
             ++   +L   L+        T  ++  LR    +  A++  E +  T K   AE+R  +
Sbjct: 1058 ALQKREVLETELQNAHGELKSTLRQLQELRDVLQK--AQLSLEEKYTTIKDLTAELRECK 1115

Query: 494  LLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSKYEEIFVKETQINKE 553
            +  E   ++QE+      +++   ELK+      + +  + +   + E+  +K     ++
Sbjct: 1116 M--EIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEK 1173

Query: 554  KEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISN 613
             E EL E   Q++    + +  + +L E   I+    QE   L   I        + +  
Sbjct: 1174 SELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEI----ERTQQRMKE 1229

Query: 614  MEDVKQELQQLRDQESKKNKDHFETLKNLENGFYINDQKADLLLLENKKLKEYILYLKNN 673
            ME V +E +Q    + K+  D  + L+        +  +      +  + +  I  L + 
Sbjct: 1230 MESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSE 1289

Query: 674  IEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTTVKIL 716
            +E  ++  +      N L+ +L A + +   L A  Q  +K L
Sbjct: 1290 LEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKL 1332



 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 160/761 (21%), Positives = 318/761 (41%), Gaps = 114/761 (14%)

Query: 131  EINTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFVLSLNQTMEKKAT 190
            E++     +   EN++E  +K + +     ++L E +EE  +        L QT + K  
Sbjct: 299  EVSAQDKVLREAENKLEQSQKMVIEK---EQSLQESKEECIKLKVDL---LEQTKQGKRA 352

Query: 191  TTVYINETYTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREV 250
                    Y    L +     +KK      E +EK +AE  I ++ LT    E EN R  
Sbjct: 353  ERQRNEALYNAEELSKAFQQYKKK----VAEKLEKVQAEEEILERNLTNC--EKENKRLQ 406

Query: 251  KRMETYQKKKELDKLQTKMSKIKETVT---VSAAVLSDHNLEI-ARLHESIRYWEQEVSE 306
            +R   Y  K EL+ L+ K+ ++KE          +++  N E+ A+L ES +   +  SE
Sbjct: 407  ERCGLY--KSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESE 464

Query: 307  LKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKT 366
            L+    IL  K     +N+E    ++   +NE L+  +Q +E+   +R+E + L + +  
Sbjct: 465  LENKDEILRDKFSLMNENRELKVRVA--AQNERLDLCQQEIES---SRVELRSLEKIISQ 519

Query: 367  LARQYKIVLSEEEKAFLQKQKIHDENQKQ----------LTFISQKEYFLSQKRVDIKNM 416
            L  + ++      K++L K ++   + K+             IS+    L+ K  +I+ +
Sbjct: 520  LPLKRELF---GFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKL 576

Query: 417  E---------EGLITLQELQQATK------------------TVYQQQIKILSANLERES 449
                      + LIT  + Q+++K                  +V  Q    ++   E+E 
Sbjct: 577  HANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKER 636

Query: 450  QRCVITQWKMACLRKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFV 509
            QR V    ++     +     + +K  +   T + Q  +   +E  + +S  + E++   
Sbjct: 637  QRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKC 696

Query: 510  AQIEKLTTELKEEEKAFVN---KEKMLMKEL-SKYEEIFVKETQINKEKEEELVEYLPQL 565
            +Q+  L  +L+E+  A+ +   K   L +EL  K E+I   ET IN E E+  + +    
Sbjct: 697  SQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAK 756

Query: 566  QVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQQLR 625
            ++  +++KE  +++E L   +  + Q+       + +  +D      ++E + + L + +
Sbjct: 757  KIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESK 816

Query: 626  DQESKKNKDHFETLKNLENGFYINDQ--------------KADLLLLEN----------- 660
             +  K+N    E LK L+N   ++++              K +L+L  N           
Sbjct: 817  GEMKKENMKKDEALKALQN--QVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEK 874

Query: 661  --KKLKEYI------LYLKNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTT 712
              KK  E +      L +KN+  +    Q  ++  +    +Q++ QE        + QT 
Sbjct: 875  QLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTK 934

Query: 713  VKILVDNGEETLQ-DINNLTDKLRERDEKMQ---HVSTWLRGSLEGL-----RLLVEQES 763
            ++  V   E+ LQ    +  +KLR+ +EK +   H +   R  +  L     ++ +E + 
Sbjct: 935  LEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQ 994

Query: 764  PMDLLSKQQLRAL-LVTSKEEKTCQLS--DLVIPNYATNIQ 801
              + LSK +   + L    E K   LS  D+++    T ++
Sbjct: 995  YKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELE 1035



 Score = 70.9 bits (172), Expect = 5e-12
 Identities = 154/806 (19%), Positives = 331/806 (41%), Gaps = 103/806 (12%)

Query: 44   EALEQLFVVEQSLQSDYFKCNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIES--MELNK 101
            E+ + +  +E  L++      ++  +  ++  + V+   +  +  +   EIES  +EL  
Sbjct: 453  ESRQSILKLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRS 512

Query: 102  LYYLLETLPNSIKRELEECVRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNE 161
            L  ++  LP  +KREL         L+ +++++   +  R     E  K  I++L     
Sbjct: 513  LEKIISQLP--LKREL---FGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISEL---RI 564

Query: 162  ALGEKQEELARKHARFVLSLNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEA-- 219
             L  K+ E+ + HA   L+ NQ + +   T     E+    +L+ E + L    + E+  
Sbjct: 565  KLAIKEAEIQKLHAN--LTANQ-LSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVK 621

Query: 220  -------EELMEKERAEYLIRKQELTAQINEFENTR--------------EVKRMETYQK 258
                    +  EKER   +   +EL  ++ + E                 ++ + E  +K
Sbjct: 622  DQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEK 681

Query: 259  KKELDKLQTKMSK-------IKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDL 311
                 KL+++M+K       +++ +       S    + A L + +    +++  L+ ++
Sbjct: 682  ASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNI 741

Query: 312  AILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQY 371
                 K+C   +  +K   I  ++  E   +I++L   L     ++K+  + M  L  Q 
Sbjct: 742  NTEHEKICLAFEKAKK---IHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSML--QQ 796

Query: 372  KIVLSEEEKAFLQ------KQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLITLQE 425
             I+  +     L       K ++  EN K+   +   +  +S++ + ++ ++  L     
Sbjct: 797  DIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSAL----- 851

Query: 426  LQQATKTVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKAE-IQAITEK- 483
              +  K      +  L  N E+  ++      ++ CL+K+      KIK   +Q  +E+ 
Sbjct: 852  --EICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKE-----LKIKNHSLQETSEQN 904

Query: 484  --IQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSKYE 541
              +Q+   ++ ++L + + R  E+     ++EK  ++L++E +         ++++ +  
Sbjct: 905  VILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKC 964

Query: 542  EIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHIF 601
            E    E  + ++K  EL     Q+++   +YKE+  K+E+   I+  +R  E   N  + 
Sbjct: 965  ESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEK--EIMHLKRDGE---NKAMH 1019

Query: 602  LFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNLENGFYINDQKADLLLL--- 658
            L   D       ++  K EL++  +   +  K    T   L        QK ++L     
Sbjct: 1020 LSQLDMI-----LDQTKTELEKKTNAVKELEKLQHSTETELTEAL----QKREVLETELQ 1070

Query: 659  ----ENKKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTTVK 714
                E K     +  L++ ++K +   E    T  DL+ +L   + + +D   E     +
Sbjct: 1071 NAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQ 1130

Query: 715  ILVDNGEETLQ---DINNLTDKLRERDEKMQHVSTWLRGSLEGLRLLVEQ-----ESPMD 766
             L +   E  Q    + +L   +RE   +M+     L G+LE   L +++     ES  D
Sbjct: 1131 ALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLND 1190

Query: 767  LL--SKQQLR--ALLVTSKEEKTCQL 788
             L  +K+QLR    ++   E++  QL
Sbjct: 1191 KLQNAKEQLREKEFIMLQNEQEISQL 1216



 Score = 54.3 bits (129), Expect = 5e-07
 Identities = 67/280 (23%), Positives = 131/280 (46%), Gaps = 28/280 (10%)

Query: 356 EYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKN 415
           E K LREK+  L +Q   ++++      + + IH E  +    +S  E    Q+   +  
Sbjct: 230 EIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLE-SAQQQAASVPI 288

Query: 416 MEEGLITLQELQQATKTVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKA 475
           +EE +I L+    A   V ++     + N   +SQ+ VI + +     K+      K+K 
Sbjct: 289 LEEQIINLEAEVSAQDKVLRE-----AENKLEQSQKMVIEKEQSLQESKEEC---IKLKV 340

Query: 476 EIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLMK 535
           ++   T++ + AE +R    NE  +  +E+S    Q +K   E  E+ +A   +E++L +
Sbjct: 341 DLLEQTKQGKRAERQR----NEALYNAEELSKAFQQYKKKVAEKLEKVQA---EEEILER 393

Query: 536 ELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDL 595
            L+  E    KE   NK  +E    Y  +L++     KEK R+L+E +N    + +   +
Sbjct: 394 NLTNCE----KE---NKRLQERCGLYKSELEI----LKEKLRQLKEENNNGKEKLRIMAV 442

Query: 596 LNNHIFLFTRDFSRYISNME-DVKQELQQLRDQESKKNKD 634
            N+ +     +  + I  +E +++ + + LRD+ S  N++
Sbjct: 443 KNSEVMAQLTESRQSILKLESELENKDEILRDKFSLMNEN 482



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 68/283 (24%), Positives = 132/283 (46%), Gaps = 39/283 (13%)

Query: 436 QQIKILSANLE--RESQRCVITQWK--MACLRKKHARWTAKIKAEIQAITEKIQNAEVRR 491
           Q+IK L   L   R+   C++TQ    M      H   T   +A++  +    Q A    
Sbjct: 229 QEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQS-RAKVSMLESAQQQAA--S 285

Query: 492 IELLNETSFR-QQEISGFVAQIEKLTTELKEEEKAFVNKEKMLM---KELSKYEEIFVKE 547
           + +L E     + E+S     + +   +L++ +K  + KE+ L    +E  K +   +++
Sbjct: 286 VPILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQ 345

Query: 548 TQINKEKEEELVEYL---PQLQVAEQEYKEK-RRKLEELSNIITAQRQEEDLLNNHIFLF 603
           T+  K  E +  E L    +L  A Q+YK+K   KLE++       + EE++L  ++   
Sbjct: 346 TKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKV-------QAEEEILERNLTNC 398

Query: 604 TRDFSR-------YISNMEDVKQELQQLRDQESK-KNKDHFETLKNLENGFYINDQKADL 655
            ++  R       Y S +E +K++L+QL+++ +  K K     +KN E    + + +  +
Sbjct: 399 EKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSI 458

Query: 656 LLLENKKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIAQ 698
           L LE++        L+N  E  R+ + +LM+ + +L  ++ AQ
Sbjct: 459 LKLESE--------LENKDEILRD-KFSLMNENRELKVRVAAQ 492


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score = 90.1 bits (222), Expect = 7e-18
 Identities = 165/849 (19%), Positives = 338/849 (39%), Gaps = 166/849 (19%)

Query: 47   EQLFVVEQSLQSDYFK----CNEEAKIFLKDIAVAVKK-LEEMRKATIDLLEIESMELNK 101
            E+L V++Q  Q++  K    C +E +  LKD  +  +  +EEM + T++ L+++  EL  
Sbjct: 629  EKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELES 688

Query: 102  L-----------------YYLLETLPNSIKRELEECVRDARRLNLFEINTIKMRITRTEN 144
            L                   +L+   + +K+ELE  + + +  +  ++++I   I   E 
Sbjct: 689  LSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSI---IKEHEV 745

Query: 145  EIELLKKKITDLTKYNEALGEKQEELARKHARFVLSLNQTMEK------KATTTVYINET 198
             I+  +K + D     E L +++++  ++H   V +L   +++      +A+  + + ++
Sbjct: 746  SIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQS 805

Query: 199  YTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQ--ELTAQINEFENTREVKRMETY 256
            Y     ++   A +++  Q  ++L++ E    L+ KQ  E+ AQ  +     +  +++  
Sbjct: 806  YQSATHEQTK-AYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQ 864

Query: 257  QKKKELDKLQTKMS-KIKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSEL----KKDL 311
               ++L+K  ++M  K+K    V  + L D N E  +  + +   E  + ++    KK++
Sbjct: 865  DLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEI 924

Query: 312  AILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQY 371
             IL  KL    D+   L++       E+  K K   + +   + + K+++E +K      
Sbjct: 925  EILTQKLSAKEDSIHILNE-------EYETKFKNQEKKMEKVKQKAKEMQETLK------ 971

Query: 372  KIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLITLQELQQATK 431
                   +K   Q+ K+  E +     +SQKE   + K +++       I+  +     +
Sbjct: 972  -------KKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGIS--DAVSRLE 1022

Query: 432  TVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAITEKIQNAEVRR 491
            T  ++QI+ L+  + R     VI+ W                        EK  N +   
Sbjct: 1023 TNQKEQIESLT-EVHRRELNDVISIW------------------------EKKLNQQAEE 1057

Query: 492  IELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSKYEEIFVKETQIN 551
            ++ ++E   +++E         +   ELK++   F  +++ + KE++  +E  VK+    
Sbjct: 1058 LQEIHEIQLQEKE---------QEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTL 1108

Query: 552  KEKEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHIFLF-------T 604
             E +E+L +    +    Q+  + +  LE+L   +    +E   L   +           
Sbjct: 1109 NELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDK 1168

Query: 605  RDFSRYISNMEDVKQELQQLRDQESKKNK---DHFETLKNLENGFYINDQ---KADLLLL 658
            R  S   S ++   +E Q L+    K NK   D     K L     I      K    LL
Sbjct: 1169 RKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALL 1228

Query: 659  ENK---------------------------KLKEYILY-------LKNNIEKYREGQEAL 684
            E K                           K+KE +L        L+  + +  E Q  L
Sbjct: 1229 EAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTL 1288

Query: 685  MHTSNDLSRQLIAQEAQYKDLWAEFQTTV---------------------KILVDNGEET 723
              +    + QL  +E Q K + A+ ++ V                       +    +E 
Sbjct: 1289 NISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKEL 1348

Query: 724  LQDINNLTDKLRERDEKMQHVSTWLRGSLEGLRLLVEQESPMDLLSKQQLRALLVTSKEE 783
             ++IN +T    E  EK   +S+    S +   L V+ ++ + L  K+   + L    +E
Sbjct: 1349 SENINAVTLMKEELKEKKVEISSL---SKQLTDLNVQLQNSISLSEKEAAISSLRKQYDE 1405

Query: 784  KTCQLSDLV 792
            + C+L D V
Sbjct: 1406 EKCELLDQV 1414



 Score = 81.3 bits (199), Expect = 3e-15
 Identities = 124/569 (21%), Positives = 251/569 (44%), Gaps = 88/569 (15%)

Query: 191 TTVYINETYTKINLKREDIALQ--KKCIQEAEELMEKERAEYLIRKQELTAQINEFENTR 248
           T+V   ET  +  +KR++  L+  K+ IQ  +E      +E    +++L  ++ E E   
Sbjct: 276 TSVKTLETLQQ-RVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELE--- 331

Query: 249 EVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSELK 308
           ++K +   +K K + +L+   + I++       V+++   +   +HE++   E+E+++L+
Sbjct: 332 KIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQ---MHETLEMKEEEIAQLR 388

Query: 309 KDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLA 368
             +  +  +     + KEK +  + +E  + L+  +   +T  A R    ++ E++KT+ 
Sbjct: 389 SRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQ---KTEEARRKLKAEMDEQIKTIE 445

Query: 369 RQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDI--KNMEEGLITLQEL 426
           +      SEEE+  LQ++                   + Q+ VD+  K+ EE +  LQ+L
Sbjct: 446 K-----TSEEERISLQQELSR----------------VKQEVVDVMKKSSEEQIAKLQKL 484

Query: 427 QQATKTVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAITEKIQN 486
            +      +Q++       ERE Q     Q K+A L K  + +    + + Q  +  ++ 
Sbjct: 485 HEKELARKEQELTKKLQTREREFQE----QMKVA-LEKSQSEYLKISQEKEQQESLALEE 539

Query: 487 AEVRRIELLNETSFR----QQEISGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSKYEE 542
            E+++  +L E+  +    QQE   +  +I +L + L++  +   N+ K L   L   + 
Sbjct: 540 LELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKN 599

Query: 543 IFVKETQINKEKEEELVEYL---------PQLQVAEQEYKEKRRKLEELSNIITAQRQEE 593
              KE  +  EK +  +E L          +LQV +Q+Y+ +  KL E       ++++E
Sbjct: 600 KHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLRE-----KCEQEKE 654

Query: 594 DLLNNHIFLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNLENGFYINDQKA 653
            LL +   +    F  +I  M +   E   ++  E        E+L +          + 
Sbjct: 655 TLLKDKEII----FQAHIEEMNEKTLEKLDVKQTE-------LESLSS----------EL 693

Query: 654 DLLLLENKKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTTV 713
             +L    KL+E +  LK+  +K ++  EA M    +  +Q +  ++  K+     Q T 
Sbjct: 694 SEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQV--DSIIKEHEVSIQRTE 751

Query: 714 KILVDNGEETLQDINNLTDKLRERDEKMQ 742
           K L D        IN L   L+ERD+ ++
Sbjct: 752 KALKD-------QINQLELLLKERDKHLK 773



 Score = 80.9 bits (198), Expect = 5e-15
 Identities = 152/771 (19%), Positives = 320/771 (41%), Gaps = 121/771 (15%)

Query: 68   KIFLKDIAVAVKK----LEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEECVRD 123
            KI ++D+   ++K    +E+  K+   + E +  + NK     +     I  E E  +  
Sbjct: 860  KIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKE----QEQTKQILVEKENMILQ 915

Query: 124  ARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFVLSLNQ 183
             R     EI  +  +++  E+ I +L ++     K  E   EK ++ A++       + +
Sbjct: 916  MREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKE-------MQE 968

Query: 184  TMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQINE 243
            T++KK               L  ++  L+K+    A EL +KE+ ++  +  E+ AQ N 
Sbjct: 969  TLKKK---------------LLDQEAKLKKELENTALELSQKEK-QFNAKMLEM-AQANS 1011

Query: 244  FENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHE-SIRYWEQ 302
               +  V R+ET QK++     +    ++ + +++    L+    E+  +HE  ++  EQ
Sbjct: 1012 AGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQ 1071

Query: 303  EVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDLRE 362
            EV+ELK+ + +                     EK E   +I  L E          +L+E
Sbjct: 1072 EVAELKQKILLFGC------------------EKEEMNKEITWLKEEGVKQDTTLNELQE 1113

Query: 363  KMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNM-EEGLI 421
            ++K  +     +  +E K     +K+  +  K L    ++  FL ++ V++K + EE   
Sbjct: 1114 QLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSL----KENTFLQEQLVELKMLAEEDKR 1169

Query: 422  TLQELQQATKTVYQQQIKILSAN------LERESQRCVITQWKMA-----CLRKKHARWT 470
             + EL    KT  ++   + S++      LE +S        ++A     C +K  A   
Sbjct: 1170 KVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLE 1229

Query: 471  AKIK-------AEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEE 523
            AK         ++  AI  +I + + R  ++      +   +S   AQ+ +LT E     
Sbjct: 1230 AKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLN 1289

Query: 524  KAFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEELS 583
             +F      L +          KE QI K  + ++   + + +  ++E   +++   E  
Sbjct: 1290 ISFQQATHQLEE----------KENQI-KSMKADIESLVTEKEALQKEGGNQQQAASEKE 1338

Query: 584  NIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNLE 643
            + IT  ++E               S  I+ +  +K+EL++ + + S  +K   +    L+
Sbjct: 1339 SCITQLKKE--------------LSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQ 1384

Query: 644  NGFYINDQKADLLLL------ENKKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIA 697
            N   +++++A +  L      E  +L + +  L   ++   + + + +   +D S +   
Sbjct: 1385 NSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSE 1444

Query: 698  QEAQYKDLWAEFQTTVKILVDNGE-------ETLQDINNLTDKLRERDEKMQHVSTWLRG 750
             + + +  + + Q TVK L    E       E  + IN L ++L +++++       L+G
Sbjct: 1445 WKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFD----CLKG 1500

Query: 751  SLEGLRLLVE-QESPMDLLSKQQLRALLVTSKE--EKTCQLSDL--VIPNY 796
             +E  +  +E +ES ++   K Q   ++       +KT ++  L  V+ NY
Sbjct: 1501 EMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNY 1551



 Score = 70.5 bits (171), Expect = 6e-12
 Identities = 125/601 (20%), Positives = 262/601 (43%), Gaps = 72/601 (11%)

Query: 44   EALEQLFVVEQSLQSDYFKCNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIESM-ELNKL 102
            EA E++  +E  + S   +  E  K  L+ + ++VK  EE  KA  D LE ES  +L +L
Sbjct: 1582 EAEEKILTLENQVYSMKAEL-ETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAEL 1640

Query: 103  YYLLETLPNSIKREL-------EECVRDARRLNLFEINTIKMRITRTENEIELLKKKITD 155
                E    +IK++L       EE  +     +L E+NT   ++   E E+ +L++K+  
Sbjct: 1641 KRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNT---KLQEREREVHILEEKLKS 1697

Query: 156  LTKYNEALGEKQEELARKHARFVLSLNQTMEKKATTTVYINETYTKINLKREDIALQKKC 215
            +        + +  +  + A+ V +   T +++A +   + +TY       E I++ ++ 
Sbjct: 1698 VES-----SQSETLIVPRSAKNVAAY--TEQEEADSQGCVQKTY------EEKISVLQRN 1744

Query: 216  IQEAEELMEK---ERAEYLIRKQELTAQINEFENTREVKRMETYQKKKELDKLQTKMSKI 272
            + E E+L+++   E+ E +    E+  Q  E     E    + ++ +  +  LQ ++ + 
Sbjct: 1745 LTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEK 1804

Query: 273  KETVTVSAAVLSD-----HNLEIARLHESIRYWEQEVSELKK-DLAILEAKLCFFTDNKE 326
             +  ++  A   +     +N++  +  E++    Q+  + K+    ILE K+        
Sbjct: 1805 NKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLV 1864

Query: 327  KLDDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQ 386
            +  ++   E  E  +K ++L        ++  D R K   L  +      E+ K+ L + 
Sbjct: 1865 RQKEVHRVEMEELTSKYEKL------QALQQMDGRNKPTELLEENT---EEKSKSHLVQP 1915

Query: 387  KIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSANLE 446
            K+    + Q   +   E+ L+    + + + + ++ LQ+  +  +  +QQ+++IL    +
Sbjct: 1916 KLLSNMEAQHNDL---EFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYD 1972

Query: 447  RESQRCVITQWKMACLRKKHARWTAKIKAEIQA-ITEKIQNAEVRRIELLNETSFRQQEI 505
            +E +  +  + +   L  KH     ++  E    + +K Q  E+   E +N+    + E+
Sbjct: 1973 QEREEKI--KQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAEL 2030

Query: 506  SGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQL 565
                  +E    E  +  K    K+  L +   +YEEI          +EEE+   +  L
Sbjct: 2031 ------LESHQEETNQLLKKIAEKDDDLKRTAKRYEEIL-------DAREEEMTAKVRDL 2077

Query: 566  QVAEQEYKEK-RRKLEELSN-------IITAQRQ--EEDLLNNHIFLFTRDFSRYISNME 615
            Q   +E ++K ++KLE+  N       I+  Q Q  ++  L +   L  ++F   I N+E
Sbjct: 2078 QTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLE 2137

Query: 616  D 616
            D
Sbjct: 2138 D 2138



 Score = 66.6 bits (161), Expect = 9e-11
 Identities = 125/581 (21%), Positives = 244/581 (41%), Gaps = 70/581 (12%)

Query: 219 AEELMEKERAEYL-IRKQELTAQINEFENTREVKRMETYQKKKELDKLQTKMSKIKETVT 277
           A +++++E+ +   I  Q     +      RE  +M+   KK   ++    + +  + ++
Sbjct: 163 AYQMLQREKKKLQGILSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYIS 222

Query: 278 VSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKN 337
           V          +++ L + +R     V  LK  L  LE +   FT  KE+  +   +   
Sbjct: 223 VLQT-------QVSLLKQRLRNGPMNVDVLKP-LPQLEPQAEVFT--KEENPESDGEPVV 272

Query: 338 EFLNKIKQLVETLHAARMEYKDLREKMKTLARQYK--IVLSEEEKAFLQKQKIHDENQKQ 395
           E    +K L ETL       ++L ++ K   + +K    L   EK  LQ+Q   DE  ++
Sbjct: 273 EDGTSVKTL-ETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQL--DERLQE 329

Query: 396 LTFISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSANLERESQRCVIT 455
           L  I  K+  +++K   I  + +    +++L+Q    V  +  + +   LE + +     
Sbjct: 330 LEKI--KDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEE----- 382

Query: 456 QWKMACLRKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKL 515
             ++A LR +  + T + + E++   EK + A    +E    T+ + +E         KL
Sbjct: 383 --EIAQLRSRIKQMTTQGE-ELREQKEKSERAAFEELEKALSTAQKTEEAR------RKL 433

Query: 516 TTELKEE----EKAFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQE 571
             E+ E+    EK    +   L +ELS+ ++  V    + K+  EE +  L +L      
Sbjct: 434 KAEMDEQIKTIEKTSEEERISLQQELSRVKQEVV---DVMKKSSEEQIAKLQKLHE---- 486

Query: 572 YKEKRRKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYIS-NMEDVKQELQQLRDQESK 630
            KE  RK +EL+  +  Q +E +          +  S Y+  + E  +QE   L + E +
Sbjct: 487 -KELARKEQELTKKL--QTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQ 543

Query: 631 KNKDHFETLKNLENGFYINDQKADLLLLENKKLKEYILYLKNNIEKYREGQEALMHTSND 690
           K     E+   L +           L  E +  +  IL L++++EK  +  +   + S D
Sbjct: 544 KKAILTESENKLRD-----------LQQEAETYRTRILELESSLEKSLQENK---NQSKD 589

Query: 691 LSRQLIAQEAQYKDLWAEFQTTVKILVDNGEETLQDINNLTDKLRERDEKMQHVSTWLRG 750
           L+  L A++ ++          + ++V+  +  L+ + +  D L    EK+Q +    + 
Sbjct: 590 LAVHLEAEKNKHNK-------EITVMVEKHKTELESLKHQQDALWT--EKLQVLKQQYQT 640

Query: 751 SLEGLRLLVEQESPMDLLSKQQLRALLVTSKEEKTCQLSDL 791
            +E LR   EQE    L  K+ +    +    EKT +  D+
Sbjct: 641 EMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDV 681



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 90/436 (20%), Positives = 192/436 (44%), Gaps = 55/436 (12%)

Query: 113  IKRELEECVRDARRLNLFEINTIKMRIT-RTENEIELLKKKITDLTKYNEA--LGEKQEE 169
            ++R L E  +  +R+   +  T+      R + +  L+K +  +  ++ +   +G  QEE
Sbjct: 1741 LQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEE 1800

Query: 170  LARKHARFVLSLNQTMEKKATTTVYINETYTKINLKR--EDI--ALQKK---C------I 216
            L  K+ ++ L + Q +EK+       N    K NL+   +D+   LQ+K   C      I
Sbjct: 1801 LEEKNKKYSLIVAQHVEKEGGK----NNIQAKQNLENVFDDVQKTLQEKELTCQILEQKI 1856

Query: 217  QEAEELMEKERAEYLIRKQELTAQINEFENTREVKRMETYQKKKELDKLQTKMSKIKETV 276
            +E +  + +++  + +  +ELT   +++E  + +++M+   K  EL  L+    +  ++ 
Sbjct: 1857 KELDSCLVRQKEVHRVEMEELT---SKYEKLQALQQMDGRNKPTEL--LEENTEEKSKSH 1911

Query: 277  TVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFF-TDNKEKLDDISNDE 335
             V   +LS+   +   L   +   E+E  +L K++  L+  L     +++++L+ +  + 
Sbjct: 1912 LVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEY 1971

Query: 336  KNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLS--EEEKAFLQKQKIHDENQ 393
              E   KIKQ  E L             +K L R++   L+  E+E     K+ I+   +
Sbjct: 1972 DQEREEKIKQEQEDLELKH------NSTLKQLMREFNTQLAQKEQELEMTIKETINKAQE 2025

Query: 394  KQLTFISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSANLERESQRCV 453
             +   +   +   +Q    I   ++ L          K   ++  +IL A  E  + +  
Sbjct: 2026 VEAELLESHQEETNQLLKKIAEKDDDL----------KRTAKRYEEILDAREEEMTAKVR 2075

Query: 454  ITQWKMACLRKKHARWTAKIKAEIQAITE-----KIQNAEVRRIELLNETSFRQQEISGF 508
              Q ++  L+KK+ +   K++ E     +     ++Q    ++  L++++  ++QE   F
Sbjct: 2076 DLQTQLEELQKKYQQ---KLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQE---F 2129

Query: 509  VAQIEKLTTELKEEEK 524
              QI  L   LK+ EK
Sbjct: 2130 REQIHNLEDRLKKYEK 2145



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 87/460 (18%), Positives = 192/460 (41%), Gaps = 68/460 (14%)

Query: 51   VVEQSLQSDYFKCNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLLETLP 110
            +V Q ++ +  K N +AK  L+++   V+K  + ++ T  +LE +               
Sbjct: 1811 IVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKI-------------- 1856

Query: 111  NSIKRELEECVRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEEL 170
                +EL+ C+     +   E++ ++M    ++ E     +++    K  E L E  EE 
Sbjct: 1857 ----KELDSCL-----VRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEK 1907

Query: 171  ARKHARFVLSLNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKERAEY 230
            ++ H          ++ K  +           N++ +   L+ K +  AE   +K   E 
Sbjct: 1908 SKSH---------LVQPKLLS-----------NMEAQHNDLEFK-LAGAEREKQKLGKEI 1946

Query: 231  LIRKQELTAQINEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEI 290
            +  +++L     E +   E+ + E  Q+++E  K + +  ++K   T+   ++ + N ++
Sbjct: 1947 VRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLK-QLMREFNTQL 2005

Query: 291  ARLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISND--EKNEFLNKIKQLVE 348
            A+  + +   E  + E       +EA+L     ++E+ + +     EK++ L +  +  E
Sbjct: 2006 AQKEQEL---EMTIKETINKAQEVEAEL--LESHQEETNQLLKKIAEKDDDLKRTAKRYE 2060

Query: 349  TLHAARME-----YKDLREKMKTLARQYKIVLSEEEKA---FLQKQKIHDENQKQLTFIS 400
             +  AR E      +DL+ +++ L ++Y+  L +EE      +   ++  +  ++ T IS
Sbjct: 2061 EILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLIS 2120

Query: 401  QKEYFLSQKRVDIKNMEEGLITLQELQQATK--------TVYQQQIKILSANLERESQRC 452
              +    + R  I N+E+ L   ++   AT          +Y   + +     E E  R 
Sbjct: 2121 DSKLKEQEFREQIHNLEDRLKKYEKNVYATTVGTPYKGGNLYHTDVSLFGEPTEFEYLRK 2180

Query: 453  VITQWKMACLRKKHARWTAKIKAEIQAITEKIQNAEVRRI 492
            V+ ++ M    K  A+    +       T+KI   E  R+
Sbjct: 2181 VLFEYMMGRETKTMAKVITTVLKFPDDQTQKILEREDARL 2220


>gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]
          Length = 1088

 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 157/752 (20%), Positives = 301/752 (40%), Gaps = 130/752 (17%)

Query: 52  VEQSLQSDYFKCNEEAKIFLKDIAVAVKKLEEMR---KATIDLLEIESMELNKLYYLLET 108
           V +  + ++ + + E +   K++ +  K LEEM    +     L      + KL  +L++
Sbjct: 259 VAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQS 318

Query: 109 LPNSIKRELEECVRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEALGEKQE 168
              S K   E+  R  R             +   E  +  L+  +    K N  L E+  
Sbjct: 319 KGLSAKATEEDHERTRR-------------LAEAEMHVHHLESLLEQKEKENSMLREEM- 364

Query: 169 ELARKHARFVLSLNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKERA 228
                H RF  +   + + KA  TV        I +K   I+  ++ +++ EE ++  ++
Sbjct: 365 -----HRRFE-NAPDSAKTKALQTV--------IEMKDSKISSMERGLRDLEEEIQMLKS 410

Query: 229 EYLIRKQELTAQINEFENTREVKRM---ETYQKKKELDKLQTKMSKIKETVTVSAAVLSD 285
              +  +E   ++ + E  R   +    +  Q K+EL +  T++  ++  +       SD
Sbjct: 411 NGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSD 470

Query: 286 HNLEIARLHESIRYWEQEVSELKKDLAI----LEAKLCFFTDNKEKLDDISND------- 334
               I  L ES+   EQ  + L+ ++      LE K        +++ D++ +       
Sbjct: 471 SKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGE 530

Query: 335 -------------EKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQ----------Y 371
                        + N    KI+ L E L     +   L+E++K+L              
Sbjct: 531 IHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTL 590

Query: 372 KIVLSEEEKAF--LQKQKIHDENQKQLTFISQKEYF------LSQKRVDIKNMEEGLITL 423
           +  L+E+E+    L++Q+  DE +KQ    + K+        +S  + D+   E  L+ L
Sbjct: 591 EEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDL 650

Query: 424 QELQQATKT---VYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAI 480
           +E   +  +       ++K L   LE++ + C+    KM    KK      + +A  + +
Sbjct: 651 KEHASSLASSGLKKDSRLKTLEIALEQKKEECL----KMESQLKKAHEAALEARASPE-M 705

Query: 481 TEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSKY 540
           +++IQ+ E       +E+S  Q E+   +  ++++  E  +++K     E+ +  +  K 
Sbjct: 706 SDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKV 765

Query: 541 EEIFVKETQINKEKEEELVEYL----PQLQVAEQEYKEKRRK----LEELSNI------I 586
             +  KE Q+ K+K  +++E        L  + Q+ ++  RK    +EEL         I
Sbjct: 766 ANLKHKE-QVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQI 824

Query: 587 TAQR-----QEEDLLNNHIFLFTRDFSRYISNMEDVKQEL-----------QQLRDQESK 630
           TA+R     QEE    N      +     +  ME VKQEL           Q L ++E+ 
Sbjct: 825 TAEREMVLAQEESARTN----AEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETH 880

Query: 631 KNKDHFETLKNLENGFYINDQKADLLLLENKKLKEYILYLKNNIEKYREGQEALMHTSND 690
                 E  K+LE    +  Q+A L  +  K     +L L ++ +K +E   AL    + 
Sbjct: 881 LTNLRAERRKHLEEVLEMK-QEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDR 939

Query: 691 LSRQLIAQEAQYKDLWAEFQTTVKILVDNGEE 722
           L +QL  Q           Q  +K++ DN E+
Sbjct: 940 LVQQLKQQT----------QNRMKLMADNYED 961



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 134/705 (19%), Positives = 293/705 (41%), Gaps = 105/705 (14%)

Query: 143 ENEIELLKKKITDLTKYNEALGEKQEELARKHARFVLSLNQTMEKKATTTVYINETYTKI 202
           + E  L K + + +T + E     QEE   +H +  +   Q ++ +      +N+ + + 
Sbjct: 195 KKERALRKDEASKITIWKEQYRVVQEE--NQHMQMTI---QALQDELRIQRDLNQLFQQD 249

Query: 203 NLKREDIALQKKCIQE-AEELMEKERAEYLIRKQELTAQINEFENTREVKRMETYQKKKE 261
           +  R      + C+ E  EE  ++  AE+  + +EL         T E   +    +K+ 
Sbjct: 250 SSSRTG----EPCVAELTEENFQRLHAEHERQAKELFL----LRKTLEEMELRIETQKQT 301

Query: 262 LDKLQTKMSKIKETVT---VSAAVLSDHNLEIARLHES---IRYWEQEVSELKKDLAILE 315
           L+     + K+ E +    +SA    + +    RL E+   + + E  + + +K+ ++L 
Sbjct: 302 LNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLR 361

Query: 316 AKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVET-LHAARMEYKDLREKMKTLARQYKIV 374
            ++        + ++  +  K + L  + ++ ++ + +     +DL E+++ L     + 
Sbjct: 362 EEM------HRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALS 415

Query: 375 LSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVY 434
             E E+   Q +     ++     I Q +  LS+K  ++  ++  L TL      +K   
Sbjct: 416 TEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSK--- 472

Query: 435 QQQIKILSANLERESQRCVITQWKMACLR----KKHARWTAKIKAEIQAITEKIQNAEVR 490
            Q I++L  +L  + QR  I Q ++  LR    +K      K K +IQ + E+       
Sbjct: 473 -QHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTK-QIQDMAEEKGTQAGE 530

Query: 491 RIELLNETSFRQQEISGFVAQIEKLTTELKEEEK---AFVNKEKMLMKELSKYEEIFVKE 547
             +L +    ++++++    +IE L  +L+++EK   +   + K L  + +  +      
Sbjct: 531 IHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTL 590

Query: 548 TQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDL--LNNHIFLFTR 605
            +   EKE  +       ++ EQ  +++R K EE+ N       ++DL  L   + L   
Sbjct: 591 EEALAEKERTIE------RLKEQRDRDEREKQEEIDNY------KKDLKDLKEKVSLLQG 638

Query: 606 DFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNLENGFYINDQKADLLLLENK---- 661
           D S   +++ D+K+    L     KK+      LK LE    +  +K + L +E++    
Sbjct: 639 DLSEKEASLLDLKEHASSLASSGLKKDS----RLKTLE--IALEQKKEECLKMESQLKKA 692

Query: 662 -----------KLKEYILYLKNNIEKYREGQ--------------EALMHTSNDLSRQLI 696
                      ++ + I +L+  I +Y++                + + +  ND  +++ 
Sbjct: 693 HEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIA 752

Query: 697 AQEAQYKD-------LWAEFQTTVKILVDNGEETLQDINNLTDKL-------RERDEKMQ 742
             E Q KD       L  + Q   K      EE  +  +NL D         R++D++++
Sbjct: 753 ELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIE 812

Query: 743 HVSTWLRGSLE---GLRLLVEQESPMDLLSKQQLRALLVTSKEEK 784
            +   LR S++      +++ QE      +++Q+  LL+  ++ K
Sbjct: 813 ELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVK 857



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 114/523 (21%), Positives = 208/523 (39%), Gaps = 71/523 (13%)

Query: 278 VSAAVLSDHNLEIAR------LHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDI 331
           VS A    H+L  AR      L   ++   +E   L+KD+ + E+KL             
Sbjct: 133 VSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKL------------- 179

Query: 332 SNDEKNEFLNKIKQLVET-LHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHD 390
                +  +N IK      L   R   KD   K+     QY++V  E +   +  Q + D
Sbjct: 180 -----SSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQD 234

Query: 391 E--NQKQLTFISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIK---ILSANL 445
           E   Q+ L  + Q++   S  R     + E     +E  Q     +++Q K   +L   L
Sbjct: 235 ELRIQRDLNQLFQQD---SSSRTGEPCVAE---LTEENFQRLHAEHERQAKELFLLRKTL 288

Query: 446 ERESQRCVITQWKMACLRKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEI 505
           E E +  + TQ +    R +  +   ++  + + ++ K    +  R   L E       +
Sbjct: 289 E-EMELRIETQKQTLNARDESIKKLLEM-LQSKGLSAKATEEDHERTRRLAEAEMHVHHL 346

Query: 506 SGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSKYEEIFVKETQIN------KEKEEELV 559
              + Q EK  + L+EE            K  +    I +K+++I+      ++ EEE+ 
Sbjct: 347 ESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQ 406

Query: 560 EYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQ 619
                  ++ +E +E+ +++E         R     + N I    ++ SR  + +  ++ 
Sbjct: 407 MLKSNGALSTEEREEEMKQME-------VYRSHSKFMKNKIGQVKQELSRKDTELLALQT 459

Query: 620 ELQQLRDQESKKNKDHFETLKNLENGFYINDQKADLLLLENKKL------KEYILYLK-N 672
           +L+ L +Q S  +K H E LK         +Q+A +L  E   L      KE +L  K  
Sbjct: 460 KLETLTNQFS-DSKQHIEVLK---ESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTK 515

Query: 673 NIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTTVKILVDNGEETLQDINNLTD 732
            I+   E +       +DL   L  +E +   L  +        ++N +E L+D      
Sbjct: 516 QIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKK--------IENLQEQLRDKEKQMS 567

Query: 733 KLRERDEKMQHVSTWLRGSLEGL-RLLVEQESPMDLLSKQQLR 774
            L+ER + +Q  +T    +L  L   L E+E  ++ L +Q+ R
Sbjct: 568 SLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDR 610


>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
            sapiens]
          Length = 1938

 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 137/751 (18%), Positives = 305/751 (40%), Gaps = 99/751 (13%)

Query: 79   KKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEECVRDARRLNLFEINTIKMR 138
            K L+E  + T+D L++E  ++N L  +   L      +LE  +   ++L   ++   K +
Sbjct: 1001 KSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTD-DLEGSLEQEKKLRA-DLERAKRK 1058

Query: 139  ITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFVLS-LNQTMEKKATTTVYINE 197
            +   E ++++ ++ I DL    + + EK      K   F LS L   ++ +   ++   +
Sbjct: 1059 L---EGDLKMSQESIMDLENDKQQIEEKL-----KKKEFELSQLQAKIDDEQVHSLQFQK 1110

Query: 198  TYTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVKRMETYQ 257
               ++  + E++  + +        +EK+R++     +E++ ++ E       +     +
Sbjct: 1111 KIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKK 1170

Query: 258  KKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAK 317
            ++ E  K++                    +LE A L       E   + L+K  A   A+
Sbjct: 1171 REAEFQKMR-------------------RDLEEATLQH-----EATAATLRKKQADSVAE 1206

Query: 318  LCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLSE 377
            L    DN +++      EK+E   +I  +   + A      ++    +T+  Q+  + ++
Sbjct: 1207 LGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAK 1266

Query: 378  EEKAFLQKQKIHDENQKQLTF----------ISQKEYFLSQ----KRVDIKNMEEGLITL 423
            +E+   Q Q IHD N ++             + +KE  +SQ    K+   + +EE    +
Sbjct: 1267 DEQ---QTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQM 1323

Query: 424  QELQQATKTV------YQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEI 477
            +E  +A   +       +    +L    E E +     Q  ++    + A+W  K + + 
Sbjct: 1324 EEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDA 1383

Query: 478  QAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLMKEL 537
               TE+++ A+ +  + L E     +  +   A +EK    L+ E +        LM++L
Sbjct: 1384 IQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVED-------LMRDL 1436

Query: 538  SKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLN 597
             +         +  +  ++ L E+              ++KL+E    + A ++E   L+
Sbjct: 1437 ERSHTACATLDKKQRNFDKVLAEW--------------KQKLDESQAELEAAQKESRSLS 1482

Query: 598  NHIFLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNLENG----FYINDQKA 653
              +F     +   +  +E +++E + L+++ S   +   ET KNL+        +  +K+
Sbjct: 1483 TELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKS 1542

Query: 654  DLLLLENKKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTTV 713
            DL +     L+E    L++   K    Q  L    ++L R++I ++ + + L    Q   
Sbjct: 1543 DLQV----ALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQ--- 1595

Query: 714  KILVDNGEETLQDINNLTDKLRERDEKMQHVSTWLRGSLEGLRLLVEQESPMDLLSKQQL 773
                    E LQ +  L  ++R R++ ++ +   + G L  + + +   +     +++ L
Sbjct: 1596 -----RAAEALQSV--LDAEIRSRNDALR-LKKKMEGDLNEMEIQLGHSNRQMAETQKHL 1647

Query: 774  RALLVTSKEEKTCQLSDLVIPNYATNIQLNI 804
            R +    K+ +   L D +  N     QL I
Sbjct: 1648 RTVQGQLKDSQ-LHLDDALRSNEDLKEQLAI 1677



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 129/724 (17%), Positives = 290/724 (40%), Gaps = 75/724 (10%)

Query: 71   LKDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEEC-VRDARRLNL 129
            L+ +   ++K +   K  ID +      L+K    +E    +++ +  E   +D ++  L
Sbjct: 1214 LQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQL 1273

Query: 130  F-EINTIKMRITRTENE----IELLKKKITDLTKYNEALGEKQEELARKHARFVLSLNQT 184
              ++N  K R+     E    +E  +  I+ LTK  +AL ++ EEL R+       + + 
Sbjct: 1274 IHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQ-------MEEE 1326

Query: 185  MEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKERAEYLI-RKQELTAQINE 243
             + K      +  +    +L RE    +++   E +  + K  +E    R +  T  I  
Sbjct: 1327 TKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQR 1386

Query: 244  FENTREVKRMETYQKKKELDKLQTKMSK---IKETVTVSAAVLSDHNLEIARLHESIRYW 300
             E   E K+    + ++  +  +T  SK   +++T       + D   ++ R H +    
Sbjct: 1387 TEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATL 1446

Query: 301  EQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKN------EFLNKIKQLVETLHAAR 354
            +++     K LA  + KL    +++ +L+    + ++      +  N  +++V+ L   R
Sbjct: 1447 DKKQRNFDKVLAEWKQKL---DESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLR 1503

Query: 355  MEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIK 414
             E K+L+E++  L  Q        ++A   K+ +  E       + + E  L  +   I 
Sbjct: 1504 RENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKIL 1563

Query: 415  NMEEGLITLQELQQATKTVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIK 474
             ++  L  ++           ++I+ L  N +R ++            R    R   K++
Sbjct: 1564 RVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKME 1623

Query: 475  AEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIE---KLTTELKEEEKAFVNKEK 531
             ++  +  ++ ++  +  E        Q ++      ++   +   +LKE+      +  
Sbjct: 1624 GDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNG 1683

Query: 532  MLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYK---EKRRKLE-------- 580
            +L++EL + +    +  +  +  E+EL++   ++Q+   +       ++KLE        
Sbjct: 1684 LLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQA 1743

Query: 581  ELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQQLRD-----QESKKNKDH 635
            E+ N I   R  E+              + I++   + +EL++ +D     +  KKN + 
Sbjct: 1744 EVENSIQESRNAEE-----------KAKKAITDAAMMAEELKKEQDTSAHLERMKKNLE- 1791

Query: 636  FETLKNLENGFYINDQKADLLLLENK----KLKEYILYLKNNIE-KYREGQEAL--MHTS 688
             +T+K+L++     D+   L L   K    KL+  +  L+N ++ + + G EAL   H  
Sbjct: 1792 -QTVKDLQHRL---DEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKY 1847

Query: 689  NDLSRQLIAQEAQ-------YKDLWAEFQTTVKILVDNGEETLQDINNLTDKLRERDEKM 741
                +++  Q  +        +DL  + Q  VK      EE  +  N    + R    ++
Sbjct: 1848 ERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQHEL 1907

Query: 742  QHVS 745
            +  +
Sbjct: 1908 EEAA 1911



 Score = 60.1 bits (144), Expect = 8e-09
 Identities = 127/567 (22%), Positives = 238/567 (41%), Gaps = 85/567 (14%)

Query: 206  REDIALQKKCIQEAEELMEKERAEYLIRKQELTAQI-NEFENTREVK-RMETYQKKKELD 263
            +E++A  +   +E EE M       L  K +L  Q+ +E EN  + + R E   K K L 
Sbjct: 864  KEELARSEARRKELEEKM----VSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSKIL- 918

Query: 264  KLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFFTD 323
             L+ K+ ++ E +     + S+       L    R  E + S LK+D+  LE  L     
Sbjct: 919  -LEAKVKELTERLEEEEEMNSE-------LVAKKRNLEDKCSSLKRDIDDLELTLT---- 966

Query: 324  NKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLS----EEE 379
              EK       EK+   NK+K L E + A       L ++ K+L   ++  L     EE+
Sbjct: 967  KVEK-------EKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEED 1019

Query: 380  K--------AFLQKQ--KIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLITLQ-ELQQ 428
            K        A L++Q   +    +++    +  E    +   D+K  +E ++ L+ + QQ
Sbjct: 1020 KVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQ 1079

Query: 429  ATKTVYQQQIKI--LSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAITEKIQN 486
              + + +++ ++  L A ++ E    +  Q K+  L+ +      +I+AE   +  KI+ 
Sbjct: 1080 IEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAE-HTLRAKIEK 1138

Query: 487  AEVRRIELLNETSFRQQEISGFV-AQIEKLTTELKEEEKAFVNKEKMLMKELSKYEEIFV 545
                    L E S R +E SG   AQIE      K+ E  F    + L +   ++E    
Sbjct: 1139 QRSDLARELEEISERLEEASGATSAQIEM----NKKREAEFQKMRRDLEEATLQHEATAA 1194

Query: 546  KETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHIFLFTR 605
               +   +   EL E +  LQ  +Q+ ++++ +L         + + +D+ +N       
Sbjct: 1195 TLRKKQADSVAELGEQIDNLQRVKQKLEKEKSEL---------KMEIDDMASN-----IE 1240

Query: 606  DFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNLENGFYINDQKADLLLLENKKLKE 665
              S+  SN+E   + ++    +   K++   + + +L      N QKA  L  +N +L  
Sbjct: 1241 ALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDL------NMQKA-RLQTQNGELSH 1293

Query: 666  YILYLKNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTTVKILVDNGEETLQ 725
             +   ++ I +  + ++AL     +L RQ+  +E + K+  A                LQ
Sbjct: 1294 RVEEKESLISQLTKSKQALTQQLEELKRQM-EEETKAKNAMA--------------HALQ 1338

Query: 726  DINNLTDKLRERDEKMQHVSTWLRGSL 752
               +  D LRE+ E+ Q     L+ +L
Sbjct: 1339 SSRHDCDLLREQYEEEQEAKAELQRAL 1365



 Score = 35.8 bits (81), Expect = 0.17
 Identities = 48/216 (22%), Positives = 89/216 (41%), Gaps = 29/216 (13%)

Query: 52   VEQSLQSDYFKCNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPN 111
            VE S+Q       E+AK  + D A+     EE++K       +E M+ N     LE    
Sbjct: 1745 VENSIQESR-NAEEKAKKAITDAAMMA---EELKKEQDTSAHLERMKKN-----LEQTVK 1795

Query: 112  SIKRELEECVRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELA 171
             ++  L+E  + A +    +I  ++ R+   ENE+++ +K+           G +  + A
Sbjct: 1796 DLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKR-----------GAEALKGA 1844

Query: 172  RKHARFVLSLNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEE-----LMEKE 226
             K+ R V  +    E+     + + +   K+  K   +   K+  +EAEE     L    
Sbjct: 1845 HKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAK---VKSYKRQAEEAEEQANTQLSRCR 1901

Query: 227  RAEYLIRKQELTAQINEFE-NTREVKRMETYQKKKE 261
            R ++ + +    A I E + N    K  +   +K E
Sbjct: 1902 RVQHELEEAAERADIAESQVNKLRAKSRDVGSQKME 1937


>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
            sapiens]
          Length = 1940

 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 138/728 (18%), Positives = 288/728 (39%), Gaps = 94/728 (12%)

Query: 79   KKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEECVRDARRLNLFEINTIKMR 138
            K L+E  +  +D L+ E  ++N L      L   ++ +LE  +   ++L +     ++  
Sbjct: 998  KALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVE-DLESSLEQEKKLRV----DLERN 1052

Query: 139  ITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFVLSLNQTMEKKATTTVYINET 198
              + E +++L ++ I DL    + L E+   L +K   +   L   +E + T  +   + 
Sbjct: 1053 KRKLEGDLKLAQESILDLENDKQQLDER---LKKKDFEYC-QLQSKVEDEQTLGLQFQKK 1108

Query: 199  YTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVKRMETYQK 258
              ++  + E++  + +  +      EK+R++Y    +EL+ ++ E       +      K
Sbjct: 1109 IKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQI--ELNK 1166

Query: 259  KKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKL 318
            K+E + L+ +                        L E+    E  V+ L+K  A   A+L
Sbjct: 1167 KREAEFLKLRRD----------------------LEEATLQHEAMVAALRKKHADSVAEL 1204

Query: 319  CFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLSEE 378
                DN +++      EK+EF  +I  L  ++ +      +L +  +TL  Q      + 
Sbjct: 1205 GEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKN 1264

Query: 379  E-------KAFLQKQKIHDENQKQLTFISQKEYFLSQ----KRVDIKNMEEGLITLQELQ 427
            E       +   QK ++  E  +    + +KE  +SQ    K+   +  EE    L+E  
Sbjct: 1265 EEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEEN 1324

Query: 428  QATKTV------YQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAIT 481
            +A   +       +    +L    E E +     Q  ++    + A+W  K + +    T
Sbjct: 1325 KAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRT 1384

Query: 482  EKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSKYE 541
            E+++ A+ +  + L ++  + + ++   A +EK    L+ E                   
Sbjct: 1385 EELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGE------------------- 1425

Query: 542  EIFVKETQINKEKEEELVEYLPQLQ-VAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHI 600
               V++  ++ E+   L   L + Q   ++   E + K EE    + A  +E   L+  +
Sbjct: 1426 ---VEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTEL 1482

Query: 601  FLFTRDFSRYISNMEDVK-------QELQQLRDQESKKNKDHFETLKNLENGFYINDQKA 653
            F     +   +  +E VK       QE+  L +Q ++  K   E  K+ +    I  +KA
Sbjct: 1483 FKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQ---IELEKA 1539

Query: 654  DLLLLENKKLKEYILYLKNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTTV 713
            D+ L     L+E    L++   K    Q  L    +++ R++  ++ + + L   +Q TV
Sbjct: 1540 DIQL----ALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTV 1595

Query: 714  KIL-------VDNGEETLQDINNLTDKLRERDEKMQHVSTWLRGSLEGLRLLVEQESPMD 766
            + +       V +  E ++    +   L E + ++ H +     +L+ LR +  Q     
Sbjct: 1596 ETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQ 1655

Query: 767  LLSKQQLR 774
            L     LR
Sbjct: 1656 LHLDDALR 1663



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 136/709 (19%), Positives = 284/709 (40%), Gaps = 100/709 (14%)

Query: 97   MELNKLYYLLETLPNS------IKRELEECVRDARRLN------LFEINTIKMRITRTEN 144
            +E++ L   +E++  S      I R LE+ + +AR  N      L E+ T K R+     
Sbjct: 1227 LEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAG 1286

Query: 145  EI--ELLKKK--ITDLTKYNEALGEKQEELARKHARFVLSLNQTMEKKATTTVYINETYT 200
            E+  +L +K+  ++ L++  +A  ++ EEL R+       L +  + K      +  +  
Sbjct: 1287 ELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQ-------LEEENKAKNALAHALQSSRH 1339

Query: 201  KINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVKRMETYQKKK 260
              +L RE    +++   E +  + K  +E         AQ      T  ++R E  ++ K
Sbjct: 1340 DCDLLREQYEEEQEGKAELQRALSKANSE--------VAQWRTKYETDAIQRTEELEEAK 1391

Query: 261  ELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCF 320
            +  KL  ++   +E V          N + A L ++ +  + EV +L  D+    +    
Sbjct: 1392 K--KLAQRLQDSEEQVEAV-------NAKCASLEKTKQRLQGEVEDLMVDVERANSLAAA 1442

Query: 321  FTDNKEKLDDI----------SNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQ 370
                +   D +          S  E    L + + L   L   +  Y++  ++++T+ R+
Sbjct: 1443 LDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRE 1502

Query: 371  YKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLITLQELQQAT 430
             K +  E+E A L +Q    EN K +  + +     S+K+++++  +  L     L++A 
Sbjct: 1503 NKNL--EQEIADLTEQIA--ENGKTIHELEK-----SRKQIELEKADIQLA----LEEAE 1549

Query: 431  KTVYQQQIKILSANLERESQRCVITQWKMACLRK--KHARWTAKIKAEIQAITEKIQNAE 488
              +  ++ KIL   LE       +TQ K    RK  +      ++K   Q   E +Q+A 
Sbjct: 1550 AALEHEEAKILRIQLE-------LTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSAL 1602

Query: 489  VRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSKYEEIFVKET 548
               +   NE    ++++ G + +IE   +    +    +   + +  +L   +       
Sbjct: 1603 DAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDAL 1662

Query: 549  QINKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHIFLFTRDFS 608
            +  ++ +E+L     +  + + E +E R  LE+         QE    N  + L     +
Sbjct: 1663 RGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNT 1722

Query: 609  RYISNMEDVKQELQQLRDQESKKNKDHFETLKNLENGFYINDQKADLLLLENKKLKEYIL 668
              I   + ++ +L QL+ +    ++D     +N E                 +K K+ I 
Sbjct: 1723 SLIHTKKKLETDLMQLQSEVEDASRD----ARNAE-----------------EKAKKAIT 1761

Query: 669  YLKNNIEKYREGQEALMHTSNDLSRQLIAQEAQYKDLWAEFQTTVKILVDNGEETLQDIN 728
                  E+ ++ Q+    TS  L R     E   KDL        ++ +  G++ +Q   
Sbjct: 1762 DAAMMAEELKKEQD----TSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQ--- 1814

Query: 729  NLTDKLRERDEKMQHVSTWLRGSLEGLRLLVEQESPMDLLSKQQLRALL 777
             L  ++RE + +++        S++GLR    +   +   S++  + +L
Sbjct: 1815 KLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVL 1863



 Score = 40.0 bits (92), Expect = 0.009
 Identities = 59/290 (20%), Positives = 123/290 (42%), Gaps = 34/290 (11%)

Query: 471  AKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKE 530
            A +K E Q   +++  +E +R EL  +     QE +    Q++  +  L + E+    + 
Sbjct: 851  ATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEE----RC 906

Query: 531  KMLMKELSKYE-EIFVKETQINKEKEEEL-VEYLPQLQVAEQEYKEKRRKLEELSNIITA 588
              L+K  +K++ E  +KE     E EEE+  E   + +  E E  E ++ +++L   +  
Sbjct: 907  DQLIK--AKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAK 964

Query: 589  QRQEEDLLNNH--------------IFLFTRDFSRYISNMEDVKQELQQLRDQESKKNKD 634
              +E+    N               I   TR+        +    +LQ   D+ +  NK 
Sbjct: 965  VEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKT 1024

Query: 635  HFETLKNLENGFYINDQKADLLLLENKKLKEYILYLKNNIE-KYREGQEALMHTSNDLSR 693
              +  + +E+         +  L + KKL+  +   K  +E   +  QE+++   ND  +
Sbjct: 1025 KSKLEQQVED--------LESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLEND--K 1074

Query: 694  QLIAQEAQYKDL-WAEFQTTVKILVDNGEETLQDINNLTDKLRERDEKMQ 742
            Q + +  + KD  + + Q+ V+     G +  + I  L  ++ E +E+++
Sbjct: 1075 QQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIE 1124



 Score = 39.7 bits (91), Expect = 0.012
 Identities = 71/310 (22%), Positives = 117/310 (37%), Gaps = 78/310 (25%)

Query: 47   EQLFVVEQS---LQSDYFKCNEEAKIFLKDIAVAVKKLEEM---RKATIDLLEIESMELN 100
            EQL +VE+    LQ++     EE +  L+    A K  E+        + LL  ++  L 
Sbjct: 1670 EQLAIVERRANLLQAEV----EELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLI 1725

Query: 101  KLYYLLETLPNSIKRELEECVRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYN 160
                 LET    ++ E+E+  RDAR                  N  E  KK ITD     
Sbjct: 1726 HTKKKLETDLMQLQSEVEDASRDAR------------------NAEEKAKKAITDAAMMA 1767

Query: 161  EALGEKQEELARKHARFVLSLNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAE 220
            E L +K+++ +    R   +L QT++                        LQ + + EAE
Sbjct: 1768 EEL-KKEQDTSAHLERMKKNLEQTVKD-----------------------LQHR-LDEAE 1802

Query: 221  ELMEK------ERAEYLIRKQELTAQINEFENTREVKRMETYQKK-KEL----------- 262
            +L  K      ++ E  IR+ E   +  + +NT  VK +  Y+++ KEL           
Sbjct: 1803 QLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNV 1862

Query: 263  -------DKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILE 315
                   DKLQ K+   K     +    + H  +  +    +   E+     +  +  L 
Sbjct: 1863 LRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAESQVNKLR 1922

Query: 316  AKLCFFTDNK 325
            AK   FT ++
Sbjct: 1923 AKTRDFTSSR 1932



 Score = 37.4 bits (85), Expect = 0.057
 Identities = 48/203 (23%), Positives = 84/203 (41%), Gaps = 27/203 (13%)

Query: 46   LEQLFVVEQSLQSDYFKCNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKLYYL 105
            L QL    +    D     E+AK  + D A+     EE++K       +E M+ N     
Sbjct: 1735 LMQLQSEVEDASRDARNAEEKAKKAITDAAMMA---EELKKEQDTSAHLERMKKN----- 1786

Query: 106  LETLPNSIKRELEECVRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEALGE 165
            LE     ++  L+E  + A +    +I  ++ RI   E E+E  +KK T+  K       
Sbjct: 1787 LEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKG------ 1840

Query: 166  KQEELARKHARFVLSLNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEE---- 221
                  RK+ R V  L    E+     + + +   K+ +K   +   K+  +EA+E    
Sbjct: 1841 -----LRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVK---VKSYKRQAEEADEQANA 1892

Query: 222  -LMEKERAEYLIRKQELTAQINE 243
             L +  +A++ + + E  A I E
Sbjct: 1893 HLTKFRKAQHELEEAEERADIAE 1915


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.129    0.341 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,396,622
Number of Sequences: 37866
Number of extensions: 1170555
Number of successful extensions: 12973
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 227
Number of HSP's successfully gapped in prelim test: 1082
Number of HSP's that attempted gapping in prelim test: 6029
Number of HSP's gapped (non-prelim): 4123
length of query: 828
length of database: 18,247,518
effective HSP length: 111
effective length of query: 717
effective length of database: 14,044,392
effective search space: 10069829064
effective search space used: 10069829064
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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