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Search of human proteins with 11139299
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|11139299 membrane-spanning 4-domains, subfamily A, member 7
isoform 1 [Homo sapiens]
(240 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|11139299 membrane-spanning 4-domains, subfamily A, member 7 i... 478 e-135
gi|46249357 membrane-spanning 4-domains, subfamily A, member 7 i... 478 e-135
gi|46249347 membrane-spanning 4-domains, subfamily A, member 7 i... 365 e-101
gi|46249359 membrane-spanning 4-domains, subfamily A, member 7 i... 365 e-101
gi|23238238 membrane-spanning 4-domains, subfamily A, member 6A ... 134 9e-32
gi|23238234 membrane-spanning 4-domains, subfamily A, member 6A ... 133 2e-31
gi|23238236 membrane-spanning 4-domains, subfamily A, member 6A ... 90 2e-18
gi|20070328 membrane-spanning 4-domains, subfamily A, member 4 i... 64 1e-10
gi|23110995 membrane-spanning 4-domains, subfamily A, member 4 i... 64 1e-10
gi|4503677 membrane-spanning 4-domains, subfamily A, member 2 is... 63 3e-10
gi|239755562 PREDICTED: membrane-spanning 4-domains, subfamily A... 60 2e-09
gi|239750062 PREDICTED: membrane-spanning 4-domains, subfamily A... 60 2e-09
gi|239744375 PREDICTED: membrane-spanning 4-domains, subfamily A... 60 2e-09
gi|73486649 membrane-spanning 4-domains, subfamily A, member 3 i... 60 2e-09
gi|214831008 membrane-spanning 4-domains, subfamily A, member 2 ... 59 4e-09
gi|23110997 membrane-spanning 4-domains, subfamily A, member 5 [... 59 4e-09
gi|8923206 membrane-spanning 4-domains, subfamily A, member 12 [... 57 1e-08
gi|21264311 membrane-spanning 4-domains, subfamily A, member 6E ... 55 7e-08
gi|149588599 membrane-spanning 4-domains, subfamily A, member 15... 52 4e-07
gi|119226217 membrane-spanning 4-domains, subfamily A, member 14... 49 4e-06
gi|13899295 membrane-spanning 4-domains, subfamily A, member 8B ... 48 9e-06
gi|169202868 PREDICTED: similar to membrane-spanning 4-domains, ... 47 1e-05
gi|169203526 PREDICTED: similar to membrane-spanning 4-domains, ... 47 1e-05
gi|169202217 PREDICTED: similar to membrane-spanning 4-domains, ... 47 1e-05
gi|23110987 membrane-spanning 4-domains, subfamily A, member 1 [... 42 4e-04
gi|23110989 membrane-spanning 4-domains, subfamily A, member 1 [... 42 4e-04
gi|119226220 membrane-spanning 4-domains, subfamily A, member 14... 41 0.001
gi|22749421 membrane-spanning 4-domains, subfamily A, member 15 ... 40 0.002
gi|167466260 membrane-spanning 4-domains, subfamily A, member 10... 39 0.004
gi|73486653 membrane-spanning 4-domains, subfamily A, member 3 i... 30 1.4
>gi|11139299 membrane-spanning 4-domains, subfamily A, member 7
isoform 1 [Homo sapiens]
Length = 240
Score = 478 bits (1230), Expect = e-135
Identities = 240/240 (100%), Positives = 240/240 (100%)
Query: 1 MLLQSQTMGVSHSFTPKGITIPQREKPGHMYQNEDYLQNGLPTETTVLGTVQILCCLLIS 60
MLLQSQTMGVSHSFTPKGITIPQREKPGHMYQNEDYLQNGLPTETTVLGTVQILCCLLIS
Sbjct: 1 MLLQSQTMGVSHSFTPKGITIPQREKPGHMYQNEDYLQNGLPTETTVLGTVQILCCLLIS 60
Query: 61 SLGAILVFAPYPSHFNPAISTTLMSGYPFLGALCFGITGSLSIISGKQSTKPFDLSSLTS 120
SLGAILVFAPYPSHFNPAISTTLMSGYPFLGALCFGITGSLSIISGKQSTKPFDLSSLTS
Sbjct: 61 SLGAILVFAPYPSHFNPAISTTLMSGYPFLGALCFGITGSLSIISGKQSTKPFDLSSLTS 120
Query: 121 NAVSSVTAGAGLFLLADSMVALRTASQHCGSEMDYLSSLPYSEYYYPIYEIKDCLLTSVS 180
NAVSSVTAGAGLFLLADSMVALRTASQHCGSEMDYLSSLPYSEYYYPIYEIKDCLLTSVS
Sbjct: 121 NAVSSVTAGAGLFLLADSMVALRTASQHCGSEMDYLSSLPYSEYYYPIYEIKDCLLTSVS 180
Query: 181 LTGVLVVMLIFTVLELLLAAYSSVFWWKQLYSNNPGSSFSSTQSQDHIQQVKKSSSRSWI 240
LTGVLVVMLIFTVLELLLAAYSSVFWWKQLYSNNPGSSFSSTQSQDHIQQVKKSSSRSWI
Sbjct: 181 LTGVLVVMLIFTVLELLLAAYSSVFWWKQLYSNNPGSSFSSTQSQDHIQQVKKSSSRSWI 240
>gi|46249357 membrane-spanning 4-domains, subfamily A, member 7
isoform 1 [Homo sapiens]
Length = 240
Score = 478 bits (1230), Expect = e-135
Identities = 240/240 (100%), Positives = 240/240 (100%)
Query: 1 MLLQSQTMGVSHSFTPKGITIPQREKPGHMYQNEDYLQNGLPTETTVLGTVQILCCLLIS 60
MLLQSQTMGVSHSFTPKGITIPQREKPGHMYQNEDYLQNGLPTETTVLGTVQILCCLLIS
Sbjct: 1 MLLQSQTMGVSHSFTPKGITIPQREKPGHMYQNEDYLQNGLPTETTVLGTVQILCCLLIS 60
Query: 61 SLGAILVFAPYPSHFNPAISTTLMSGYPFLGALCFGITGSLSIISGKQSTKPFDLSSLTS 120
SLGAILVFAPYPSHFNPAISTTLMSGYPFLGALCFGITGSLSIISGKQSTKPFDLSSLTS
Sbjct: 61 SLGAILVFAPYPSHFNPAISTTLMSGYPFLGALCFGITGSLSIISGKQSTKPFDLSSLTS 120
Query: 121 NAVSSVTAGAGLFLLADSMVALRTASQHCGSEMDYLSSLPYSEYYYPIYEIKDCLLTSVS 180
NAVSSVTAGAGLFLLADSMVALRTASQHCGSEMDYLSSLPYSEYYYPIYEIKDCLLTSVS
Sbjct: 121 NAVSSVTAGAGLFLLADSMVALRTASQHCGSEMDYLSSLPYSEYYYPIYEIKDCLLTSVS 180
Query: 181 LTGVLVVMLIFTVLELLLAAYSSVFWWKQLYSNNPGSSFSSTQSQDHIQQVKKSSSRSWI 240
LTGVLVVMLIFTVLELLLAAYSSVFWWKQLYSNNPGSSFSSTQSQDHIQQVKKSSSRSWI
Sbjct: 181 LTGVLVVMLIFTVLELLLAAYSSVFWWKQLYSNNPGSSFSSTQSQDHIQQVKKSSSRSWI 240
>gi|46249347 membrane-spanning 4-domains, subfamily A, member 7
isoform 2 [Homo sapiens]
Length = 195
Score = 365 bits (938), Expect = e-101
Identities = 195/240 (81%), Positives = 195/240 (81%), Gaps = 45/240 (18%)
Query: 1 MLLQSQTMGVSHSFTPKGITIPQREKPGHMYQNEDYLQNGLPTETTVLGTVQILCCLLIS 60
MLLQSQTMGVSHSFTPKGITIPQREKPGHMYQNEDYLQNGLPTETTVLG
Sbjct: 1 MLLQSQTMGVSHSFTPKGITIPQREKPGHMYQNEDYLQNGLPTETTVLG----------- 49
Query: 61 SLGAILVFAPYPSHFNPAISTTLMSGYPFLGALCFGITGSLSIISGKQSTKPFDLSSLTS 120
FGITGSLSIISGKQSTKPFDLSSLTS
Sbjct: 50 ----------------------------------FGITGSLSIISGKQSTKPFDLSSLTS 75
Query: 121 NAVSSVTAGAGLFLLADSMVALRTASQHCGSEMDYLSSLPYSEYYYPIYEIKDCLLTSVS 180
NAVSSVTAGAGLFLLADSMVALRTASQHCGSEMDYLSSLPYSEYYYPIYEIKDCLLTSVS
Sbjct: 76 NAVSSVTAGAGLFLLADSMVALRTASQHCGSEMDYLSSLPYSEYYYPIYEIKDCLLTSVS 135
Query: 181 LTGVLVVMLIFTVLELLLAAYSSVFWWKQLYSNNPGSSFSSTQSQDHIQQVKKSSSRSWI 240
LTGVLVVMLIFTVLELLLAAYSSVFWWKQLYSNNPGSSFSSTQSQDHIQQVKKSSSRSWI
Sbjct: 136 LTGVLVVMLIFTVLELLLAAYSSVFWWKQLYSNNPGSSFSSTQSQDHIQQVKKSSSRSWI 195
>gi|46249359 membrane-spanning 4-domains, subfamily A, member 7
isoform 2 [Homo sapiens]
Length = 195
Score = 365 bits (938), Expect = e-101
Identities = 195/240 (81%), Positives = 195/240 (81%), Gaps = 45/240 (18%)
Query: 1 MLLQSQTMGVSHSFTPKGITIPQREKPGHMYQNEDYLQNGLPTETTVLGTVQILCCLLIS 60
MLLQSQTMGVSHSFTPKGITIPQREKPGHMYQNEDYLQNGLPTETTVLG
Sbjct: 1 MLLQSQTMGVSHSFTPKGITIPQREKPGHMYQNEDYLQNGLPTETTVLG----------- 49
Query: 61 SLGAILVFAPYPSHFNPAISTTLMSGYPFLGALCFGITGSLSIISGKQSTKPFDLSSLTS 120
FGITGSLSIISGKQSTKPFDLSSLTS
Sbjct: 50 ----------------------------------FGITGSLSIISGKQSTKPFDLSSLTS 75
Query: 121 NAVSSVTAGAGLFLLADSMVALRTASQHCGSEMDYLSSLPYSEYYYPIYEIKDCLLTSVS 180
NAVSSVTAGAGLFLLADSMVALRTASQHCGSEMDYLSSLPYSEYYYPIYEIKDCLLTSVS
Sbjct: 76 NAVSSVTAGAGLFLLADSMVALRTASQHCGSEMDYLSSLPYSEYYYPIYEIKDCLLTSVS 135
Query: 181 LTGVLVVMLIFTVLELLLAAYSSVFWWKQLYSNNPGSSFSSTQSQDHIQQVKKSSSRSWI 240
LTGVLVVMLIFTVLELLLAAYSSVFWWKQLYSNNPGSSFSSTQSQDHIQQVKKSSSRSWI
Sbjct: 136 LTGVLVVMLIFTVLELLLAAYSSVFWWKQLYSNNPGSSFSSTQSQDHIQQVKKSSSRSWI 195
>gi|23238238 membrane-spanning 4-domains, subfamily A, member 6A
isoform 1 [Homo sapiens]
Length = 248
Score = 134 bits (336), Expect = 9e-32
Identities = 80/201 (39%), Positives = 111/201 (55%), Gaps = 3/201 (1%)
Query: 19 ITIPQREKPGHMYQNEDYLQNGLPTETTVLGTVQILCCLLISSLGAILVFAPYPSHFNPA 78
I Q EKP Q +D L+ L E V+GT+QILC +++ SLG IL A + +F
Sbjct: 19 INFSQAEKPEPTNQGQDSLKKHLHAEIKVIGTIQILCGMMVLSLGIILASASFSPNFTQV 78
Query: 79 ISTTLMSGYPFLGALCFGITGSLSIISGKQSTKPFDLSSLTSNAVSSVTAGAGLFLLADS 138
ST L S YPF+G F I+GSLSI + K+ TK SSL + +S+++A G +L+
Sbjct: 79 TSTLLNSAYPFIGPFFFIISGSLSIATEKRLTKLLVHSSLVGSILSALSALVGFIILSVK 138
Query: 139 MVALRTASQHCGSEMDYLSSLPYSEYYY--PIYEIKDCLLTSVSLTGVLVVMLIFTVLEL 196
L AS C + + + + Y Y+Y +Y DC SL G L +MLI T+LE
Sbjct: 139 QATLNPASLQCELDKNNIPTRSYVSYFYHDSLY-TTDCYTAKASLAGTLSLMLICTLLEF 197
Query: 197 LLAAYSSVFWWKQLYSNNPGS 217
LA ++V WKQ YS+ PGS
Sbjct: 198 CLAVLTAVLRWKQAYSDFPGS 218
>gi|23238234 membrane-spanning 4-domains, subfamily A, member 6A
isoform 2 [Homo sapiens]
Length = 225
Score = 133 bits (334), Expect = 2e-31
Identities = 80/202 (39%), Positives = 111/202 (54%), Gaps = 3/202 (1%)
Query: 19 ITIPQREKPGHMYQNEDYLQNGLPTETTVLGTVQILCCLLISSLGAILVFAPYPSHFNPA 78
I Q EKP Q +D L+ L E V+GT+QILC +++ SLG IL A + +F
Sbjct: 19 INFSQAEKPEPTNQGQDSLKKHLHAEIKVIGTIQILCGMMVLSLGIILASASFSPNFTQV 78
Query: 79 ISTTLMSGYPFLGALCFGITGSLSIISGKQSTKPFDLSSLTSNAVSSVTAGAGLFLLADS 138
ST L S YPF+G F I+GSLSI + K+ TK SSL + +S+++A G +L+
Sbjct: 79 TSTLLNSAYPFIGPFFFIISGSLSIATEKRLTKLLVHSSLVGSILSALSALVGFIILSVK 138
Query: 139 MVALRTASQHCGSEMDYLSSLPYSEYYY--PIYEIKDCLLTSVSLTGVLVVMLIFTVLEL 196
L AS C + + + + Y Y+Y +Y DC SL G L +MLI T+LE
Sbjct: 139 QATLNPASLQCELDKNNIPTRSYVSYFYHDSLY-TTDCYTAKASLAGTLSLMLICTLLEF 197
Query: 197 LLAAYSSVFWWKQLYSNNPGSS 218
LA ++V WKQ YS+ PG S
Sbjct: 198 CLAVLTAVLRWKQAYSDFPGVS 219
>gi|23238236 membrane-spanning 4-domains, subfamily A, member 6A
isoform 3 [Homo sapiens]
Length = 178
Score = 90.1 bits (222), Expect = 2e-18
Identities = 54/136 (39%), Positives = 74/136 (54%)
Query: 19 ITIPQREKPGHMYQNEDYLQNGLPTETTVLGTVQILCCLLISSLGAILVFAPYPSHFNPA 78
I Q EKP Q +D L+ L E V+GT+QILC +++ SLG IL A + +F
Sbjct: 19 INFSQAEKPEPTNQGQDSLKKHLHAEIKVIGTIQILCGMMVLSLGIILASASFSPNFTQV 78
Query: 79 ISTTLMSGYPFLGALCFGITGSLSIISGKQSTKPFDLSSLTSNAVSSVTAGAGLFLLADS 138
ST L S YPF+G F I+GSLSI + K+ TK SSL + +S+++A G +L+
Sbjct: 79 TSTLLNSAYPFIGPFFFIISGSLSIATEKRLTKLLVHSSLVGSILSALSALVGFIILSVK 138
Query: 139 MVALRTASQHCGSEMD 154
L AS S D
Sbjct: 139 QATLNPASLQWNSLSD 154
>gi|20070328 membrane-spanning 4-domains, subfamily A, member 4
isoform a [Homo sapiens]
Length = 220
Score = 63.9 bits (154), Expect = 1e-10
Identities = 66/227 (29%), Positives = 98/227 (43%), Gaps = 27/227 (11%)
Query: 9 GVSHSFTPKGITIPQREKPGHMYQNEDYLQNGLPT-----ETTVLGTVQILCCLLISSLG 63
G+ + G +PQ G+M +L GL E VLG VQIL L+ S+G
Sbjct: 6 GMEQAMPGAGPGVPQL---GNMAVIHSHLWKGLQEKFLKGEPKVLGVVQILTALMSLSMG 62
Query: 64 AILVFAPYPSHFNPAISTTLMSGYPFLGALCFGITGSLSIISGKQSTKPFDLSSLTSNAV 123
++ ++ + IS + GY G++ F I+GSLSI +G ++TK SL N
Sbjct: 63 ITMMCMASNTYGSNPISVYI--GYTIWGSVMFIISGSLSIAAGIRTTKGLVRGSLGMNIT 120
Query: 124 SSVTAGAGLFLLADSMVALRTASQHCGSEMDYLSSLPYSEYYYPIYEIKDCLLTSVSLTG 183
SSV A +G+ + S+ Y PY YY +C T L G
Sbjct: 121 SSVLAASGILINTFSLAF-------------YSFHHPYCNYY---GNSNNCHGTMSILMG 164
Query: 184 VLVVMLIFTVLELLLAAYSSVFWWKQLYSNNPGSSFSSTQSQDHIQQ 230
+ ++L+ +VLE +A S F K L PG S H+ +
Sbjct: 165 LDGMVLLLSVLEFCIAVSLSAFGCKVLCC-TPGGVVLILPSHSHMAE 210
>gi|23110995 membrane-spanning 4-domains, subfamily A, member 4
isoform b [Homo sapiens]
Length = 239
Score = 63.9 bits (154), Expect = 1e-10
Identities = 66/227 (29%), Positives = 98/227 (43%), Gaps = 27/227 (11%)
Query: 9 GVSHSFTPKGITIPQREKPGHMYQNEDYLQNGLPT-----ETTVLGTVQILCCLLISSLG 63
G+ + G +PQ G+M +L GL E VLG VQIL L+ S+G
Sbjct: 25 GMEQAMPGAGPGVPQL---GNMAVIHSHLWKGLQEKFLKGEPKVLGVVQILTALMSLSMG 81
Query: 64 AILVFAPYPSHFNPAISTTLMSGYPFLGALCFGITGSLSIISGKQSTKPFDLSSLTSNAV 123
++ ++ + IS + GY G++ F I+GSLSI +G ++TK SL N
Sbjct: 82 ITMMCMASNTYGSNPISVYI--GYTIWGSVMFIISGSLSIAAGIRTTKGLVRGSLGMNIT 139
Query: 124 SSVTAGAGLFLLADSMVALRTASQHCGSEMDYLSSLPYSEYYYPIYEIKDCLLTSVSLTG 183
SSV A +G+ + S+ Y PY YY +C T L G
Sbjct: 140 SSVLAASGILINTFSLAF-------------YSFHHPYCNYY---GNSNNCHGTMSILMG 183
Query: 184 VLVVMLIFTVLELLLAAYSSVFWWKQLYSNNPGSSFSSTQSQDHIQQ 230
+ ++L+ +VLE +A S F K L PG S H+ +
Sbjct: 184 LDGMVLLLSVLEFCIAVSLSAFGCKVLCC-TPGGVVLILPSHSHMAE 229
>gi|4503677 membrane-spanning 4-domains, subfamily A, member 2
isoform 1 [Homo sapiens]
Length = 244
Score = 62.8 bits (151), Expect = 3e-10
Identities = 48/158 (30%), Positives = 73/158 (46%), Gaps = 20/158 (12%)
Query: 41 LPTETTVLGTVQILCCLLISSLGAILVFAPYPSHFNPAISTTLMSGYPFLGALCFGITGS 100
L E LG QIL ++ G ++ SH I ++ +GYPF GA+ F I+G
Sbjct: 54 LKKEQEFLGVTQILTAMICLCFGTVVCSVLDISHIEGDIFSSFKAGYPFWGAIFFSISGM 113
Query: 101 LSIISGKQSTKPFDLSSLTSNAVSSVTAGAGLFLLADSMVALRTASQHCGSEMDYLSSLP 160
LSIIS +++ SL +N SS+ G G+ +L ++ SL
Sbjct: 114 LSIISERRNATYLVRGSLGANTASSIAGGTGITILI----------------INLKKSLA 157
Query: 161 YSEYY--YPIYEIKDCLLTSVSLTGVLVVMLIFTVLEL 196
Y + +E K C + S S T ++V+ML T+L L
Sbjct: 158 YIHIHSCQKFFETK-CFMASFS-TEIVVMMLFLTILGL 193
>gi|239755562 PREDICTED: membrane-spanning 4-domains, subfamily A,
member 4E isoform 1 [Homo sapiens]
Length = 243
Score = 60.1 bits (144), Expect = 2e-09
Identities = 56/203 (27%), Positives = 90/203 (44%), Gaps = 19/203 (9%)
Query: 29 HMYQNEDYLQNGLPTETTVLGTVQILCCLLISSLGAILVFAPYPSHFNPAISTTLMSGYP 88
H Y + + + VLG V+IL L+ S+G I++ + S+ I + Y
Sbjct: 51 HSYLCKGLQEKFFKRKPKVLGVVRILIALMSLSMGIIMMCVAFSSYEEHPIFVYV--AYT 108
Query: 89 FLGALCFGITGSLSIISGKQSTKPFDLSSLTSNAVSSVTAGAGLFLLADSMVALRTASQH 148
G++ F I+ SLS+ +G ++TK SL N SSV A +G+ + A S+ +
Sbjct: 109 IWGSVMFIISVSLSVAAGIRTTKGLVGGSLGKNITSSVLAISGILINAISLTFYSFRYHY 168
Query: 149 CGSEMDYLSSLPYSEYYYPIYEIKDCLLTSVSLTGVLVVMLIFTVLELLLAAYSSVFWWK 208
C D LSS +C +T L G ++L+ +VLE +A S F K
Sbjct: 169 CNH--DQLSS--------------NCYMTMSILMGTDGMVLLLSVLEFCIAVSLSAFGCK 212
Query: 209 QLYSNNPGSSFSSTQSQDHIQQV 231
L +P T S H+ ++
Sbjct: 213 VLCC-SPSEVVLITPSNSHMAEI 234
>gi|239750062 PREDICTED: membrane-spanning 4-domains, subfamily A,
member 4E isoform 3 [Homo sapiens]
Length = 243
Score = 60.1 bits (144), Expect = 2e-09
Identities = 56/203 (27%), Positives = 90/203 (44%), Gaps = 19/203 (9%)
Query: 29 HMYQNEDYLQNGLPTETTVLGTVQILCCLLISSLGAILVFAPYPSHFNPAISTTLMSGYP 88
H Y + + + VLG V+IL L+ S+G I++ + S+ I + Y
Sbjct: 51 HSYLCKGLQEKFFKRKPKVLGVVRILIALMSLSMGIIMMCVAFSSYEEHPIFVYV--AYT 108
Query: 89 FLGALCFGITGSLSIISGKQSTKPFDLSSLTSNAVSSVTAGAGLFLLADSMVALRTASQH 148
G++ F I+ SLS+ +G ++TK SL N SSV A +G+ + A S+ +
Sbjct: 109 IWGSVMFIISVSLSVAAGIRTTKGLVGGSLGKNITSSVLAISGILINAISLTFYSFRYHY 168
Query: 149 CGSEMDYLSSLPYSEYYYPIYEIKDCLLTSVSLTGVLVVMLIFTVLELLLAAYSSVFWWK 208
C D LSS +C +T L G ++L+ +VLE +A S F K
Sbjct: 169 CNH--DQLSS--------------NCYMTMSILMGTDGMVLLLSVLEFCIAVSLSAFGCK 212
Query: 209 QLYSNNPGSSFSSTQSQDHIQQV 231
L +P T S H+ ++
Sbjct: 213 VLCC-SPSEVVLITPSNSHMAEI 234
>gi|239744375 PREDICTED: membrane-spanning 4-domains, subfamily A,
member 4E isoform 3 [Homo sapiens]
Length = 243
Score = 60.1 bits (144), Expect = 2e-09
Identities = 56/203 (27%), Positives = 90/203 (44%), Gaps = 19/203 (9%)
Query: 29 HMYQNEDYLQNGLPTETTVLGTVQILCCLLISSLGAILVFAPYPSHFNPAISTTLMSGYP 88
H Y + + + VLG V+IL L+ S+G I++ + S+ I + Y
Sbjct: 51 HSYLCKGLQEKFFKRKPKVLGVVRILIALMSLSMGIIMMCVAFSSYEEHPIFVYV--AYT 108
Query: 89 FLGALCFGITGSLSIISGKQSTKPFDLSSLTSNAVSSVTAGAGLFLLADSMVALRTASQH 148
G++ F I+ SLS+ +G ++TK SL N SSV A +G+ + A S+ +
Sbjct: 109 IWGSVMFIISVSLSVAAGIRTTKGLVGGSLGKNITSSVLAISGILINAISLTFYSFRYHY 168
Query: 149 CGSEMDYLSSLPYSEYYYPIYEIKDCLLTSVSLTGVLVVMLIFTVLELLLAAYSSVFWWK 208
C D LSS +C +T L G ++L+ +VLE +A S F K
Sbjct: 169 CNH--DQLSS--------------NCYMTMSILMGTDGMVLLLSVLEFCIAVALSAFGCK 212
Query: 209 QLYSNNPGSSFSSTQSQDHIQQV 231
L +P T S H+ ++
Sbjct: 213 VLCC-SPSEVVLITPSNSHMAEI 234
>gi|73486649 membrane-spanning 4-domains, subfamily A, member 3
isoform a [Homo sapiens]
Length = 214
Score = 59.7 bits (143), Expect = 2e-09
Identities = 48/178 (26%), Positives = 81/178 (45%), Gaps = 16/178 (8%)
Query: 30 MYQNEDYLQNGLPTETTVLGTVQILCCLLISSLGAILVFAPYPSHFNPAIST-TLMSGYP 88
+YQ D + + VLG +QIL +I +LG L YP HF T +GYP
Sbjct: 33 VYQPIDGSPDYQKAKLQVLGAIQILNAAMILALGVFLGSLQYPYHFQKHFFFFTFYTGYP 92
Query: 89 FLGALCFGITGSLSIISGKQSTKPFDLSSLTSNAVSSVTAGAGLFLLADSMVALRTASQH 148
GA+ F +G+LS+++G + T+ + +S N S+ A G L+ ++ + +
Sbjct: 93 IWGAVFFCSSGTLSVVAGIKPTRTWIQNSFGMNIASATIALVGTAFLSLNIAVNIQSLRS 152
Query: 149 CGSEMDYLSSLPYSEYYYPIYEIKDCLLTSVSLTGVLVVMLIFTVLELLLAAYSSVFW 206
C S + Y + S+S G++ ++LI T+LEL + + W
Sbjct: 153 CHSSSESPDLCNY--------------MGSIS-NGMVSLLLILTLLELCVTISTIAMW 195
>gi|214831008 membrane-spanning 4-domains, subfamily A, member 2
isoform 2 [Homo sapiens]
Length = 195
Score = 58.9 bits (141), Expect = 4e-09
Identities = 33/95 (34%), Positives = 49/95 (51%)
Query: 41 LPTETTVLGTVQILCCLLISSLGAILVFAPYPSHFNPAISTTLMSGYPFLGALCFGITGS 100
L E LG QIL ++ G ++ SH I ++ +GYPF GA+ F I+G
Sbjct: 54 LKKEQEFLGVTQILTAMICLCFGTVVCSVLDISHIEGDIFSSFKAGYPFWGAIFFSISGM 113
Query: 101 LSIISGKQSTKPFDLSSLTSNAVSSVTAGAGLFLL 135
LSIIS +++ SL +N SS+ G G+ +L
Sbjct: 114 LSIISERRNATYLVRGSLGANTASSIAGGTGITIL 148
>gi|23110997 membrane-spanning 4-domains, subfamily A, member 5
[Homo sapiens]
Length = 200
Score = 58.9 bits (141), Expect = 4e-09
Identities = 46/177 (25%), Positives = 85/177 (48%), Gaps = 26/177 (14%)
Query: 31 YQNEDYLQNGLPTETTVLGTVQILCCLLISSLGAILVFA---PYPSHFNPAISTTLMSGY 87
+ + LQ + +LGT+QIL ++ S G I +F PYP P I +SGY
Sbjct: 33 FSTQSPLQKLFARKMKILGTIQILFGIMTFSFGVIFLFTLLKPYPRF--PFI---FLSGY 87
Query: 88 PFLGALCFGITGSLSIISGKQSTKPFDLSSLTSNAVSSVTAGAGLFLLADSMVALRTASQ 147
PF G++ F +G+ I +++T+ + S N +S++ A AG+ LL +
Sbjct: 88 PFWGSVLFINSGAFLIAVKRKTTETLIILSRIMNFLSALGAIAGIILLTFGFIL------ 141
Query: 148 HCGSEMDYLSSLPYSEYYYPIYEIKDCLLTSVSLTGVLVVMLIFTVLELLLAAYSSV 204
+ +Y+ YS ++ C +V G+L+ ++ F+++EL ++ S+
Sbjct: 142 ----DQNYICG--YS------HQNSQCKAVTVLFLGILITLMTFSIIELFISLPFSI 186
>gi|8923206 membrane-spanning 4-domains, subfamily A, member 12
[Homo sapiens]
Length = 267
Score = 57.0 bits (136), Expect = 1e-08
Identities = 60/216 (27%), Positives = 91/216 (42%), Gaps = 44/216 (20%)
Query: 3 LQSQTMGVSHSFTPKGITIP---QREKPGHMYQNEDYLQNGLPT-------ETTVLGTVQ 52
L++Q G + P GIT P +PG N + + T E LG +Q
Sbjct: 39 LENQAQGAQRA-QPYGITSPGIFASSQPGQ--GNIQMINPSVGTAVMNFKEEAKALGVIQ 95
Query: 53 ILCCLLISSLGAILVFAPYPSHFNPAI---STTLMSGYPFLGALCFGITGSLSIISGKQS 109
I+ L+ G +L + F + ST ++ GYPF G L F I+GSLS+ + K+
Sbjct: 96 IMVGLMHIGFGIVLCLISFS--FREVLGFASTAVIGGYPFWGGLSFIISGSLSVSASKEL 153
Query: 110 TKPFDLSSLTSNAVSSVTAGAGLFLLADSMVALRTASQHCGSEMDYLSSLPYSEYYYPIY 169
++ SL N VSS+ A G+ LL M A Q DY + L
Sbjct: 154 SRCLVKGSLGMNIVSSILAFIGVILLLVDMCINGVAGQ------DYWAVL---------- 197
Query: 170 EIKDCLLTSVSLTGVLVVMLIFTVLELLLAAYSSVF 205
S G+ ++IF++LE +A ++ F
Sbjct: 198 ----------SGKGISATLMIFSLLEFFVACATAHF 223
>gi|21264311 membrane-spanning 4-domains, subfamily A, member 6E
[Homo sapiens]
Length = 147
Score = 54.7 bits (130), Expect = 7e-08
Identities = 37/95 (38%), Positives = 51/95 (53%), Gaps = 2/95 (2%)
Query: 116 SSLTSNAVSSVTAGAGLFLLADSMVALRTASQHCG-SEMDYLSSLPYSEYYYPIYEIKDC 174
SSL + +S+++A G LL+ + AL AS C E D + L S Y+ Y + DC
Sbjct: 52 SSLAGSILSALSALVGFILLSVNPAALNPASLQCKLDEKDIPTRLLLSYDYHSPYTM-DC 110
Query: 175 LLTSVSLTGVLVVMLIFTVLELLLAAYSSVFWWKQ 209
SL G L +ML+ TVLE LA ++V WKQ
Sbjct: 111 HRAKASLAGTLSLMLVSTVLEFCLAVLTAVLQWKQ 145
Score = 31.2 bits (69), Expect = 0.84
Identities = 20/63 (31%), Positives = 31/63 (49%), Gaps = 3/63 (4%)
Query: 19 ITIPQREKPGHMYQNEDYLQNGLPTETTVLGTVQILCCLLISSLGAILVF---APYPSHF 75
I Q EKP Q +D L+ L + V+G L ++S+L A++ F + P+
Sbjct: 19 INFSQAEKPEPTNQGQDSLKKRLQAKVKVIGVHSSLAGSILSALSALVGFILLSVNPAAL 78
Query: 76 NPA 78
NPA
Sbjct: 79 NPA 81
>gi|149588599 membrane-spanning 4-domains, subfamily A, member 15
isoform 1 [Homo sapiens]
Length = 240
Score = 52.4 bits (124), Expect = 4e-07
Identities = 41/120 (34%), Positives = 57/120 (47%), Gaps = 8/120 (6%)
Query: 16 PKGITIPQREKPGHMYQNEDYLQNGLPTETTVLGTVQILCCLLISSLGAILVFAPYPSHF 75
P G P+ +P + E +L E VLGTVQIL L+ G++L+ H
Sbjct: 46 PLGAQTPRATQPPDLRPVETFLTG----EPKVLGTVQILIGLIHLGFGSVLLMVRR-GHV 100
Query: 76 NPAISTTLMSGYPFLGALCFGITGSLSIISGKQSTKPFDLSSLTSNAVSSVTAGAGLFLL 135
+ G PF G CF I+GSLS+ + K T SSL +N +S + A AG +L
Sbjct: 101 GIFF---IEGGVPFWGGACFIISGSLSVAAEKNHTSCLVRSSLGTNILSVMAAFAGTAIL 157
>gi|119226217 membrane-spanning 4-domains, subfamily A, member 14
isoform 1 [Homo sapiens]
Length = 679
Score = 48.9 bits (115), Expect = 4e-06
Identities = 36/119 (30%), Positives = 59/119 (49%), Gaps = 7/119 (5%)
Query: 31 YQNEDYLQNGLPTETTVLGTVQILCCLLISSLGAILVFAPYPSHFNPAISTTLMSGYPFL 90
Y+ L + L E VLG QIL L+I G I FA F+ + +++GYPF
Sbjct: 28 YRPHSSLLDFLKGEPRVLGATQILLALIIVGFGTI--FALNYIGFSQRLPLVVLTGYPFW 85
Query: 91 GALCFGITGSLSIISGKQSTKPFDLSSLTSNAVSSVTAGAGLFLLADSMVALRTASQHC 149
GAL F +TG L++ K ++ + N +SS+ A G+ ++++ R ++C
Sbjct: 86 GALIFILTGYLTVTDKKSKLLGQGVTGM--NVISSLVAITGITF---TILSYRHQDKYC 139
>gi|13899295 membrane-spanning 4-domains, subfamily A, member 8B
[Homo sapiens]
Length = 250
Score = 47.8 bits (112), Expect = 9e-06
Identities = 48/173 (27%), Positives = 76/173 (43%), Gaps = 31/173 (17%)
Query: 39 NGLPTETTV-----LGTVQILCCLLISSLGAILVFAPYPSHFNPAISTTLMSGYPFLGAL 93
NG P + + LG +QI+ L LG+I+ + +S + G+PF G L
Sbjct: 58 NGQPVQKALKEGKTLGAIQIIIGLAHIGLGSIMATVLVGEY----LSISFYGGFPFWGGL 113
Query: 94 CFGITGSLSIISGKQSTKPFDLS-SLTSNAVSSVTAGAGLFLLADSMVALRTASQHCGSE 152
F I+GSLS+ + Q LS SL N VS++ + G+ L +
Sbjct: 114 WFIISGSLSVAAENQPYSYCLLSGSLGLNIVSAICSAVGVILFITDL------------- 160
Query: 153 MDYLSSLPYSEYYYPIYEIKDCLLTSVSLTGVLVVMLIFTVLELLLAAYSSVF 205
S+P+ Y Y + ++++GVL L+F +LE +A SS F
Sbjct: 161 -----SIPHPYAYPDYYPYAWGVNPGMAISGVL---LVFCLLEFGIACASSHF 205
>gi|169202868 PREDICTED: similar to membrane-spanning 4-domains,
subfamily A, member 8B [Homo sapiens]
Length = 391
Score = 47.0 bits (110), Expect = 1e-05
Identities = 36/120 (30%), Positives = 60/120 (50%), Gaps = 13/120 (10%)
Query: 19 ITIPQREKPGHMYQNEDYLQNGLPTETTVLGT-VQILCCL--LISSLGAILVFAPYPSHF 75
+ + Q G Q Y Q P T L T +QIL L + S++ +L + P+
Sbjct: 120 LVVNQNSAAGVQSQPIGY-QRQYPVGTASLQTAIQILIGLTHIFSAINPVLYYYPF---- 174
Query: 76 NPAISTTLMSGYPFLGALCFGITGSLSIISGKQSTKPFDLSSLTSNAVSSVTAGAGLFLL 135
T +SGYP G L + ++GSLS+ + K + SS++ N +S++ A AG+F++
Sbjct: 175 -----VTWLSGYPLWGGLSYIVSGSLSVWAAKDPSPCVVNSSISFNIISALFAFAGIFII 229
>gi|169203526 PREDICTED: similar to membrane-spanning 4-domains,
subfamily A, member 8B [Homo sapiens]
Length = 391
Score = 47.0 bits (110), Expect = 1e-05
Identities = 36/120 (30%), Positives = 60/120 (50%), Gaps = 13/120 (10%)
Query: 19 ITIPQREKPGHMYQNEDYLQNGLPTETTVLGT-VQILCCL--LISSLGAILVFAPYPSHF 75
+ + Q G Q Y Q P T L T +QIL L + S++ +L + P+
Sbjct: 120 LVVNQNSAAGVQSQPIGY-QRQYPVGTASLQTAIQILIGLTHIFSAINPVLYYYPF---- 174
Query: 76 NPAISTTLMSGYPFLGALCFGITGSLSIISGKQSTKPFDLSSLTSNAVSSVTAGAGLFLL 135
T +SGYP G L + ++GSLS+ + K + SS++ N +S++ A AG+F++
Sbjct: 175 -----VTWLSGYPLWGGLSYIVSGSLSVWAAKDPSPCVVNSSISFNIISALFAFAGIFII 229
>gi|169202217 PREDICTED: similar to membrane-spanning 4-domains,
subfamily A, member 8B [Homo sapiens]
Length = 391
Score = 47.0 bits (110), Expect = 1e-05
Identities = 36/120 (30%), Positives = 60/120 (50%), Gaps = 13/120 (10%)
Query: 19 ITIPQREKPGHMYQNEDYLQNGLPTETTVLGT-VQILCCL--LISSLGAILVFAPYPSHF 75
+ + Q G Q Y Q P T L T +QIL L + S++ +L + P+
Sbjct: 120 LVVNQNSAAGVQSQPIGY-QRQYPVGTASLQTAIQILIGLTHIFSAINPVLYYYPF---- 174
Query: 76 NPAISTTLMSGYPFLGALCFGITGSLSIISGKQSTKPFDLSSLTSNAVSSVTAGAGLFLL 135
T +SGYP G L + ++GSLS+ + K + SS++ N +S++ A AG+F++
Sbjct: 175 -----VTWLSGYPLWGGLSYIVSGSLSVWAAKDPSPCVVNSSISFNIISALFAFAGIFII 229
>gi|23110987 membrane-spanning 4-domains, subfamily A, member 1
[Homo sapiens]
Length = 297
Score = 42.4 bits (98), Expect = 4e-04
Identities = 51/206 (24%), Positives = 85/206 (41%), Gaps = 34/206 (16%)
Query: 44 ETTVLGTVQILCCLLISSLGAILVFAPYPSHFNPAISTTLMSGYPFLGALCFGITGSLSI 103
E+ LG VQI+ L +LG +L+ P+ I T+ YP G + + I+GSL
Sbjct: 48 ESKTLGAVQIMNGLFHIALGGLLMI---PAGIYAPICVTVW--YPLWGGIMYIISGSLLA 102
Query: 104 ISGKQSTKPFDLSSLTSNAVSSVTAGAGL--------------FLLADSMVALRTASQH- 148
+ K S K + N++S A +G+ FL +S+ +R + +
Sbjct: 103 ATEKNSRKCLVKGKMIMNSLSLFAAISGMILSIMDILNIKISHFLKMESLNFIRAHTPYI 162
Query: 149 ----CGSEMDYLSSLPYSEYYYPIYEIKDCLLTSVSLTGVLVVMLIFTVLELLLAAYSSV 204
C + P ++Y Y I + G+L VMLIF + L+ A
Sbjct: 163 NIYNCEPANPSEKNSPSTQYCYSIQSL---------FLGILSVMLIFAFFQELVIAGIVE 213
Query: 205 FWWKQLYSNNPGSSFSSTQSQDHIQQ 230
WK+ S P S+ +++ +Q
Sbjct: 214 NEWKRTCS-RPKSNIVLLSAEEKKEQ 238
>gi|23110989 membrane-spanning 4-domains, subfamily A, member 1
[Homo sapiens]
Length = 297
Score = 42.4 bits (98), Expect = 4e-04
Identities = 51/206 (24%), Positives = 85/206 (41%), Gaps = 34/206 (16%)
Query: 44 ETTVLGTVQILCCLLISSLGAILVFAPYPSHFNPAISTTLMSGYPFLGALCFGITGSLSI 103
E+ LG VQI+ L +LG +L+ P+ I T+ YP G + + I+GSL
Sbjct: 48 ESKTLGAVQIMNGLFHIALGGLLMI---PAGIYAPICVTVW--YPLWGGIMYIISGSLLA 102
Query: 104 ISGKQSTKPFDLSSLTSNAVSSVTAGAGL--------------FLLADSMVALRTASQH- 148
+ K S K + N++S A +G+ FL +S+ +R + +
Sbjct: 103 ATEKNSRKCLVKGKMIMNSLSLFAAISGMILSIMDILNIKISHFLKMESLNFIRAHTPYI 162
Query: 149 ----CGSEMDYLSSLPYSEYYYPIYEIKDCLLTSVSLTGVLVVMLIFTVLELLLAAYSSV 204
C + P ++Y Y I + G+L VMLIF + L+ A
Sbjct: 163 NIYNCEPANPSEKNSPSTQYCYSIQSL---------FLGILSVMLIFAFFQELVIAGIVE 213
Query: 205 FWWKQLYSNNPGSSFSSTQSQDHIQQ 230
WK+ S P S+ +++ +Q
Sbjct: 214 NEWKRTCS-RPKSNIVLLSAEEKKEQ 238
>gi|119226220 membrane-spanning 4-domains, subfamily A, member 14
isoform 2 [Homo sapiens]
Length = 662
Score = 40.8 bits (94), Expect = 0.001
Identities = 42/148 (28%), Positives = 61/148 (41%), Gaps = 18/148 (12%)
Query: 31 YQNEDYLQNGLPTETTVLGTVQILCCLLISSLGAILVFAPYPSHFNPAISTTLMSGYPFL 90
Y+ L + L E VLG QIL L+I G I FA F+ + +++GYPF
Sbjct: 28 YRPHSSLLDFLKGEPRVLGATQILLALIIVGFGTI--FALNYIGFSQRLPLVVLTGYPFW 85
Query: 91 GALC-FGITG-------------SLSIISGKQSTKPFDLSSLTSNAVSSVTAGAGLFLLA 136
GAL G+TG + +I+S + K + S V S T LF L
Sbjct: 86 GALIGQGVTGMNVISSLVAITGITFTILSYRHQDKYCQMPSFEEICVFSRTLFIVLFFLP 145
Query: 137 DSMVALRTASQHCGSEMDYLSSLPYSEY 164
+ + + Q E D L + E+
Sbjct: 146 SDVT--QNSEQPAPEENDQLQFVLQEEF 171
>gi|22749421 membrane-spanning 4-domains, subfamily A, member 15
isoform 2 [Homo sapiens]
Length = 147
Score = 39.7 bits (91), Expect = 0.002
Identities = 22/50 (44%), Positives = 29/50 (58%)
Query: 86 GYPFLGALCFGITGSLSIISGKQSTKPFDLSSLTSNAVSSVTAGAGLFLL 135
G PF G CF I+GSLS+ + K T SSL +N +S + A AG +L
Sbjct: 15 GVPFWGGACFIISGSLSVAAEKNHTSCLVRSSLGTNILSVMAAFAGTAIL 64
>gi|167466260 membrane-spanning 4-domains, subfamily A, member 10
[Homo sapiens]
Length = 267
Score = 38.9 bits (89), Expect = 0.004
Identities = 42/161 (26%), Positives = 65/161 (40%), Gaps = 26/161 (16%)
Query: 48 LGTVQILCCLLISSLGAILVFAPYPSHFNPAISTTLMSGYPFLGALCFGITGSLSIISGK 107
LG I LL G L H L S YPF GA F I+G L+I
Sbjct: 60 LGAFHITIALLHLVFGGYLASIVKNLHL-----VVLKSWYPFWGAASFLISGILAITMKT 114
Query: 108 QSTKPFDLSSLTSNAVSSVTAGAGLFLLADSMVALRTASQHCGSEMDYLSSLPYSEYYYP 167
S + L +N +S +GLF+++ + +L S P+ +
Sbjct: 115 FSKTYLKMLCLMTNLISLFCVLSGLFVISKDL---------------FLES-PFESPIWR 158
Query: 168 IYEIKDCLLTSVSLTGVLVVMLIFTVLELLLAAYSSVFWWK 208
+Y ++V + + + +L FTVLEL L ++V W+
Sbjct: 159 MYP-----NSTVHIQRLELALLCFTVLELFLPVPTAVTAWR 194
>gi|73486653 membrane-spanning 4-domains, subfamily A, member 3
isoform b [Homo sapiens]
Length = 168
Score = 30.4 bits (67), Expect = 1.4
Identities = 27/117 (23%), Positives = 52/117 (44%), Gaps = 15/117 (12%)
Query: 90 LGALCFGITGSLSIISGKQSTKPFDLSSLTSNAVSSVTAGAGLFLLADSMVALRTASQHC 149
L L F +G+LS+++G + T+ + +S N S+ A G L+ ++ + + C
Sbjct: 48 LQVLGFCSSGTLSVVAGIKPTRTWIQNSFGMNIASATIALVGTAFLSLNIAVNIQSLRSC 107
Query: 150 GSEMDYLSSLPYSEYYYPIYEIKDCLLTSVSLTGVLVVMLIFTVLELLLAAYSSVFW 206
S + Y + S+S G++ ++LI T+LEL + + W
Sbjct: 108 HSSSESPDLCNY--------------MGSIS-NGMVSLLLILTLLELCVTISTIAMW 149
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.132 0.388
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 8,368,822
Number of Sequences: 37866
Number of extensions: 332801
Number of successful extensions: 860
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 28
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 805
Number of HSP's gapped (non-prelim): 43
length of query: 240
length of database: 18,247,518
effective HSP length: 99
effective length of query: 141
effective length of database: 14,498,784
effective search space: 2044328544
effective search space used: 2044328544
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.