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Search of human proteins with 16876443
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|16876443 sperm-associated cation channel 2 isoform 1 [Homo
sapiens]
(528 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|16876443 sperm-associated cation channel 2 isoform 1 [Homo sa... 1028 0.0
gi|26051223 sperm-associated cation channel 2 isoform 2 [Homo sa... 1023 0.0
gi|26051227 sperm-associated cation channel 2 isoform 4 [Homo sa... 374 e-103
gi|150417969 voltage-gated sodium channel type V alpha isoform d... 100 4e-21
gi|4502523 calcium channel, voltage-dependent, N type, alpha 1B ... 100 6e-21
gi|20070163 voltage-dependent calcium channel alpha 1G subunit i... 99 7e-21
gi|38505284 voltage-dependent calcium channel alpha 1G subunit i... 99 7e-21
gi|38505282 voltage-dependent calcium channel alpha 1G subunit i... 99 7e-21
gi|38505280 voltage-dependent calcium channel alpha 1G subunit i... 99 7e-21
gi|38505278 voltage-dependent calcium channel alpha 1G subunit i... 99 7e-21
gi|38505270 voltage-dependent calcium channel alpha 1G subunit i... 99 7e-21
gi|62988334 cation channel, sperm associated 4 [Homo sapiens] 98 2e-20
gi|38505292 voltage-dependent calcium channel alpha 1G subunit i... 98 2e-20
gi|38505288 voltage-dependent calcium channel alpha 1G subunit i... 98 2e-20
gi|38505276 voltage-dependent calcium channel alpha 1G subunit i... 98 2e-20
gi|38505274 voltage-dependent calcium channel alpha 1G subunit i... 98 2e-20
gi|38505272 voltage-dependent calcium channel alpha 1G subunit i... 98 2e-20
gi|38505268 voltage-dependent calcium channel alpha 1G subunit i... 98 2e-20
gi|38505290 voltage-dependent calcium channel alpha 1G subunit i... 97 5e-20
gi|38505286 voltage-dependent calcium channel alpha 1G subunit i... 97 5e-20
gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H... 96 1e-19
gi|53832009 calcium channel, voltage-dependent, T type, alpha 1H... 96 1e-19
gi|53832005 calcium channel, voltage-dependent, R type, alpha 1E... 95 1e-19
gi|193788732 calcium channel, voltage-dependent, L type, alpha 1... 94 3e-19
gi|193788730 calcium channel, voltage-dependent, L type, alpha 1... 94 3e-19
gi|193788728 calcium channel, voltage-dependent, L type, alpha 1... 94 3e-19
gi|193788724 calcium channel, voltage-dependent, L type, alpha 1... 94 3e-19
gi|193788720 calcium channel, voltage-dependent, L type, alpha 1... 94 3e-19
gi|120433602 calcium channel, voltage-dependent, L type, alpha 1... 94 3e-19
gi|193788548 calcium channel, voltage-dependent, L type, alpha 1... 94 3e-19
>gi|16876443 sperm-associated cation channel 2 isoform 1 [Homo
sapiens]
Length = 528
Score = 1028 bits (2657), Expect = 0.0
Identities = 528/528 (100%), Positives = 528/528 (100%)
Query: 1 MAAYQQEEQMQLPRADAIRSRLIDTFSLIEHLQGLSQAVPRHTIRELLDPSRQKKLVLGD 60
MAAYQQEEQMQLPRADAIRSRLIDTFSLIEHLQGLSQAVPRHTIRELLDPSRQKKLVLGD
Sbjct: 1 MAAYQQEEQMQLPRADAIRSRLIDTFSLIEHLQGLSQAVPRHTIRELLDPSRQKKLVLGD 60
Query: 61 QHQLVRFSIKPQRIEQISHAQRLLSRLHVRCSQRPPLSLWAGWVLECPLFKNFIIFLVFL 120
QHQLVRFSIKPQRIEQISHAQRLLSRLHVRCSQRPPLSLWAGWVLECPLFKNFIIFLVFL
Sbjct: 61 QHQLVRFSIKPQRIEQISHAQRLLSRLHVRCSQRPPLSLWAGWVLECPLFKNFIIFLVFL 120
Query: 121 NTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWLSNFSVFWKSAWNVF 180
NTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWLSNFSVFWKSAWNVF
Sbjct: 121 NTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWLSNFSVFWKSAWNVF 180
Query: 181 DFVVTMLSLLPEVVVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKS 240
DFVVTMLSLLPEVVVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKS
Sbjct: 181 DFVVTMLSLLPEVVVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKS 240
Query: 241 MTFLLMLLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWY 300
MTFLLMLLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWY
Sbjct: 241 MTFLLMLLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWY 300
Query: 301 ALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREV 360
ALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREV
Sbjct: 301 ALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREV 360
Query: 361 QLKADMFKRQIIQRRKNMSHEALTSSHSKIEDRGASQQRESLDLSEVSEVESNYGATEED 420
QLKADMFKRQIIQRRKNMSHEALTSSHSKIEDRGASQQRESLDLSEVSEVESNYGATEED
Sbjct: 361 QLKADMFKRQIIQRRKNMSHEALTSSHSKIEDRGASQQRESLDLSEVSEVESNYGATEED 420
Query: 421 LITSASKTEETLSKKREYQSSSCVSSTSSSYSSSSESRFSESIGRLDWETLVHENLPGLM 480
LITSASKTEETLSKKREYQSSSCVSSTSSSYSSSSESRFSESIGRLDWETLVHENLPGLM
Sbjct: 421 LITSASKTEETLSKKREYQSSSCVSSTSSSYSSSSESRFSESIGRLDWETLVHENLPGLM 480
Query: 481 EMDQDDRVWPRDSLFRYFELLEKLQYNLEERKKLQEFAVQALMNLEDK 528
EMDQDDRVWPRDSLFRYFELLEKLQYNLEERKKLQEFAVQALMNLEDK
Sbjct: 481 EMDQDDRVWPRDSLFRYFELLEKLQYNLEERKKLQEFAVQALMNLEDK 528
>gi|26051223 sperm-associated cation channel 2 isoform 2 [Homo
sapiens]
Length = 530
Score = 1023 bits (2644), Expect = 0.0
Identities = 528/530 (99%), Positives = 528/530 (99%), Gaps = 2/530 (0%)
Query: 1 MAAYQQEEQMQLPRADAIRSRLIDTFSLIEHLQGLSQAVPRHTIRELLDPSRQKKLVLGD 60
MAAYQQEEQMQLPRADAIRSRLIDTFSLIEHLQGLSQAVPRHTIRELLDPSRQKKLVLGD
Sbjct: 1 MAAYQQEEQMQLPRADAIRSRLIDTFSLIEHLQGLSQAVPRHTIRELLDPSRQKKLVLGD 60
Query: 61 QHQLVRFSIKPQRIEQISHAQRLLSRLHVRCSQRPPLSLWAGWVLECPLFKNFIIFLVFL 120
QHQLVRFSIKPQRIEQISHAQRLLSRLHVRCSQRPPLSLWAGWVLECPLFKNFIIFLVFL
Sbjct: 61 QHQLVRFSIKPQRIEQISHAQRLLSRLHVRCSQRPPLSLWAGWVLECPLFKNFIIFLVFL 120
Query: 121 NTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWLSNFSVFWKSAWNVF 180
NTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWLSNFSVFWKSAWNVF
Sbjct: 121 NTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWLSNFSVFWKSAWNVF 180
Query: 181 DFVVTMLSLLPEVVVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKS 240
DFVVTMLSLLPEVVVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKS
Sbjct: 181 DFVVTMLSLLPEVVVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKS 240
Query: 241 MTFLLMLLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWY 300
MTFLLMLLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWY
Sbjct: 241 MTFLLMLLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWY 300
Query: 301 ALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREV 360
ALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREV
Sbjct: 301 ALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREV 360
Query: 361 QLKADMFKRQIIQRRKNMSHEALTSSHSKIED--RGASQQRESLDLSEVSEVESNYGATE 418
QLKADMFKRQIIQRRKNMSHEALTSSHSKIED RGASQQRESLDLSEVSEVESNYGATE
Sbjct: 361 QLKADMFKRQIIQRRKNMSHEALTSSHSKIEDSSRGASQQRESLDLSEVSEVESNYGATE 420
Query: 419 EDLITSASKTEETLSKKREYQSSSCVSSTSSSYSSSSESRFSESIGRLDWETLVHENLPG 478
EDLITSASKTEETLSKKREYQSSSCVSSTSSSYSSSSESRFSESIGRLDWETLVHENLPG
Sbjct: 421 EDLITSASKTEETLSKKREYQSSSCVSSTSSSYSSSSESRFSESIGRLDWETLVHENLPG 480
Query: 479 LMEMDQDDRVWPRDSLFRYFELLEKLQYNLEERKKLQEFAVQALMNLEDK 528
LMEMDQDDRVWPRDSLFRYFELLEKLQYNLEERKKLQEFAVQALMNLEDK
Sbjct: 481 LMEMDQDDRVWPRDSLFRYFELLEKLQYNLEERKKLQEFAVQALMNLEDK 530
>gi|26051227 sperm-associated cation channel 2 isoform 4 [Homo
sapiens]
Length = 199
Score = 374 bits (959), Expect = e-103
Identities = 187/187 (100%), Positives = 187/187 (100%)
Query: 1 MAAYQQEEQMQLPRADAIRSRLIDTFSLIEHLQGLSQAVPRHTIRELLDPSRQKKLVLGD 60
MAAYQQEEQMQLPRADAIRSRLIDTFSLIEHLQGLSQAVPRHTIRELLDPSRQKKLVLGD
Sbjct: 1 MAAYQQEEQMQLPRADAIRSRLIDTFSLIEHLQGLSQAVPRHTIRELLDPSRQKKLVLGD 60
Query: 61 QHQLVRFSIKPQRIEQISHAQRLLSRLHVRCSQRPPLSLWAGWVLECPLFKNFIIFLVFL 120
QHQLVRFSIKPQRIEQISHAQRLLSRLHVRCSQRPPLSLWAGWVLECPLFKNFIIFLVFL
Sbjct: 61 QHQLVRFSIKPQRIEQISHAQRLLSRLHVRCSQRPPLSLWAGWVLECPLFKNFIIFLVFL 120
Query: 121 NTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWLSNFSVFWKSAWNVF 180
NTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWLSNFSVFWKSAWNVF
Sbjct: 121 NTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWLSNFSVFWKSAWNVF 180
Query: 181 DFVVTML 187
DFVVTML
Sbjct: 181 DFVVTML 187
>gi|150417969 voltage-gated sodium channel type V alpha isoform d
[Homo sapiens]
Length = 1998
Score = 100 bits (248), Expect = 4e-21
Identities = 74/267 (27%), Positives = 141/267 (52%), Gaps = 24/267 (8%)
Query: 104 VLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILL 163
++E F+ FIIF++ L++ L E LE T +K+ LE A +F+LE+LL
Sbjct: 1201 IVEHSWFETFIIFMILLSSGALAFEDIYLEERKT----IKVLLEYADKMFTYVFVLEMLL 1256
Query: 164 KWLS-NFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRICRVLRSLKLLA 222
KW++ F ++ +AW DF++ +SL+ V +G ++ LR R LR L+ L+
Sbjct: 1257 KWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGP-IKSLRTLRALRPLRALS 1315
Query: 223 QFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFS-EYTRSPRQ-----DLEY 276
+F +++++ LV A+ S+ +L++ LIF+ IF++ GV +F+ ++ R Q L Y
Sbjct: 1316 RFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNY 1375
Query: 277 HVFFS-------DLPNSLVTVFILFTLDH----WYALLQDVWKVPEVS-RIFSSIYFILW 324
+ + +L L + D+ + ALLQ + P+ ++ IYF+++
Sbjct: 1376 TIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVYEEQPQWEYNLYMYIYFVIF 1435
Query: 325 LLLGSIIFRSIIVAMMVTNFQNIRKEL 351
++ GS ++ + +++ NF +K+L
Sbjct: 1436 IIFGSFFTLNLFIGVIIDNFNQQKKKL 1462
Score = 73.2 bits (178), Expect = 6e-13
Identities = 69/348 (19%), Positives = 165/348 (47%), Gaps = 41/348 (11%)
Query: 47 LLDPSRQKKLVLGDQHQLVRFSIKPQRIEQISHAQRLLSRLHVRCSQRP---PLSLWAGW 103
++D Q+K LG Q + E+ + +L + Q+P PL+ + G+
Sbjct: 1451 IIDNFNQQKKKLGGQDIFMT--------EEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGF 1502
Query: 104 VLECPLFKNF---IIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILE 160
+ + + F I+FL+ LN + +MVE + + + K+ + ++ F+ IF E
Sbjct: 1503 IFDIVTKQAFDVTIMFLICLNMVTMMVETD--DQSPEKI---NILAKINLLFVA-IFTGE 1556
Query: 161 ILLKWLSNFSVFWKSAWNVFDFVVTMLSLLPEVV--VLVGVTGQSVWLQLLRICRVLRSL 218
++K + ++ ++WN+FDFVV +LS++ V+ ++ +++R+ R+ R L
Sbjct: 1557 CIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRIL 1616
Query: 219 KLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHV 278
+L+ + I+ ++ L+ +L ++ + +LL + +I+++ G+ F+ D ++
Sbjct: 1617 RLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFN- 1675
Query: 279 FFSDLPNSLVTVFILFTLDHWYALLQDVWKV------PEV-----------SRIFSSIYF 321
F NS++ +F + T W LL + P + S ++F
Sbjct: 1676 -FQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFF 1734
Query: 322 ILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADMFKR 369
++++ +I ++ +A+++ NF +E E ++ + + +++++
Sbjct: 1735 TTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEK 1782
Score = 61.2 bits (147), Expect = 2e-09
Identities = 93/431 (21%), Positives = 180/431 (41%), Gaps = 78/431 (18%)
Query: 114 IIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWLS-NFSVF 172
I + LNT+ + +E + S ++ L+V IF E+ K ++ + +
Sbjct: 723 ITMCIVLNTLFMALEHYNMTSEFEEM------LQVGNLVFTGIFTAEMTFKIIALDPYYY 776
Query: 173 WKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQIQIIIL 232
++ WN+FD ++ +LSL+ +G++ S L +LR R+LR KL + + +I
Sbjct: 777 FQQGWNIFDSIIVILSLME-----LGLSRMSN-LSVLRSFRLLRVFKLAKSWPTLNTLIK 830
Query: 233 VLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSE---YTRSPRQDLEYHVFFSDLPNSLVT 289
++ ++ ++ L ++L I +IFAV G+ +F + R L D ++ +
Sbjct: 831 IIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLI 890
Query: 290 VFILFTLDHWYALLQDVWKVPEVS-RIFSSIYFILWLLLGSIIFRSIIVAMMVTNF---- 344
+F + W ++ +W EVS + + F+L +++G+++ ++ +A+++++F
Sbjct: 891 IFRIL-CGEW---IETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADN 946
Query: 345 ----QNIRKELNEEMARREVQLKADMFKRQI------IQRRKNMSHEAL----------- 383
R+ N ++A +Q KR + R++ AL
Sbjct: 947 LTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIA 1006
Query: 384 ---------------TSSHSKIEDRGASQQRESLDLSEV----SEVESNYGATEEDLITS 424
T ++ E+ Q D V + ES+ EED S
Sbjct: 1007 TPYSPPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENS 1066
Query: 425 ASKTEETLSKKREYQ----------SSSCVSSTSSSYSSSSESRFSESIGRLDWETLVHE 474
TEE SK++E Q S S S++ SS +E+ S++ R W+
Sbjct: 1067 LG-TEEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWK--AEP 1123
Query: 475 NLPGLMEMDQD 485
PG E +D
Sbjct: 1124 QAPGCGETPED 1134
Score = 47.8 bits (112), Expect = 3e-05
Identities = 68/271 (25%), Positives = 116/271 (42%), Gaps = 51/271 (18%)
Query: 6 QEEQMQLPRADAIRSRLIDTFSLIEHLQGLSQAVPRHTIRELL---DP--SRQKK-LVLG 59
QE + LP +A R +L + L L P+ I E L DP S QK +VL
Sbjct: 40 QESREGLPEEEAPRPQL--DLQASKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLN 97
Query: 60 DQHQLVRFSIKPQRIEQISHAQRLLSRLHVRCSQRPPLSLWAGWVLECPLFKNFIIFLVF 119
+ RFS ++A +LS H P+ A +L LF N +I
Sbjct: 98 KGKTIFRFSA--------TNALYVLSPFH-------PIRRAAVKILVHSLF-NMLIMCTI 141
Query: 120 LNTIILMVE------IELLESTNTKLWPLKLTLEVAA-WFILLIFILEILLKWLSNFSVF 172
L + M + + +E T T ++ + +++ A F L F F
Sbjct: 142 LTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLHAF-------------TF 188
Query: 173 WKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQIQIIIL 232
+ WN DF V +++ + E + L L LR RVLR+LK ++ ++ I+
Sbjct: 189 LRDPWNWLDFSVIIMAYVSENIKLGN-------LSALRTFRVLRALKTISVIPGLKTIVG 241
Query: 233 VLVRALKSMTFLLMLLLIFFYIFAVTGVYVF 263
L++++K + +++L + +FA+ G+ +F
Sbjct: 242 ALIQSVKKLADVMVLTVFCLSVFALIGLQLF 272
Score = 35.0 bits (79), Expect = 0.17
Identities = 32/135 (23%), Positives = 61/135 (45%), Gaps = 18/135 (13%)
Query: 280 FSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAM 339
F + + +F L T D W L Q + +I+ I+F+L + LGS ++I+A+
Sbjct: 355 FDSFAWAFLALFRLMTQDCWERLYQQTLR--SAGKIYM-IFFMLVIFLGSFYLVNLILAV 411
Query: 340 MVTNFQNIRKELNEEMARREVQLKADMFKRQIIQRRKNMSHEALTSSHSKIEDRGA-SQQ 398
+ + E Q +A + + + ++R + E L H + RG +
Sbjct: 412 VAMAY--------------EEQNQATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVS 457
Query: 399 RESLDLSEVSEVESN 413
R SL++S ++ V S+
Sbjct: 458 RSSLEMSPLAPVNSH 472
>gi|4502523 calcium channel, voltage-dependent, N type, alpha 1B
subunit [Homo sapiens]
Length = 2339
Score = 99.8 bits (247), Expect = 6e-21
Identities = 64/254 (25%), Positives = 129/254 (50%), Gaps = 18/254 (7%)
Query: 108 PLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWLS 167
P F+ FI+ ++ LNT++LM++ + +L L+ +F +E +LK ++
Sbjct: 1471 PPFEYFIMAMIALNTVVLMMKFY------DAPYEYELMLKCLNIVFTSMFSMECVLKIIA 1524
Query: 168 NFSV--FWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRICRVLRSLKLLAQFR 225
F V +++ AWNVFDFV + S+ +V + T + L LR+ R R +KLL Q
Sbjct: 1525 -FGVLNYFRDAWNVFDFVTVLGSITDILVTEIAETNNFINLSFLRLFRAARLIKLLRQGY 1583
Query: 226 QIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPN 285
I+I++ V++ K++ ++ +L+ + F+I+A+ G+ VF + H F
Sbjct: 1584 TIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQ 1643
Query: 286 SLVTVFILFTLDHWYALL---------QDVWKVPEVSRIFSSIYFILWLLLGSIIFRSII 336
+L+ +F T + W+ ++ + E F+ YF+ ++ L S + ++
Sbjct: 1644 ALMLLFRSATGEAWHEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLCSFLMLNLF 1703
Query: 337 VAMMVTNFQNIRKE 350
VA+++ NF+ + ++
Sbjct: 1704 VAVIMDNFEYLTRD 1717
Score = 86.3 bits (212), Expect = 6e-17
Identities = 67/241 (27%), Positives = 125/241 (51%), Gaps = 11/241 (4%)
Query: 142 LKLTLEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVT 200
L TL A + L +F+ E+ LK +++S++N FDF V + S+ EVV
Sbjct: 510 LTTTLYFAEFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSVF-EVVWAAIKP 568
Query: 201 GQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGV 260
G S + +LR R+LR K+ + ++ +++ L+ ++KS+ LL LL +F +FA+ G+
Sbjct: 569 GSSFGISVLRALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGM 628
Query: 261 YVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALL-QDVWKVPEVSR-IFSS 318
+F QD F P +++TVF + T + W A++ + VS+ +FSS
Sbjct: 629 QLFGGQFNF--QDETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVSKGMFSS 686
Query: 319 IYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADMFKRQIIQRRKNM 378
YFI+ L G+ ++ +A+ V N N +E+ + E +++ ++ +Q+ K +
Sbjct: 687 FYFIVLTLFGNYTLLNVFLAIAVDNLANA-----QELTKDEEEMEEAANQKLALQKAKEV 741
Query: 379 S 379
+
Sbjct: 742 A 742
Score = 70.1 bits (170), Expect = 5e-12
Identities = 66/329 (20%), Positives = 146/329 (44%), Gaps = 54/329 (16%)
Query: 103 WVLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEIL 162
+++ F+ I+ ++ L++I L E + + P L+ + +F E++
Sbjct: 1145 YIVTMRYFEVVILVVIALSSIALAAEDPVRTDS-----PRNNALKYLDYIFTGVFTFEMV 1199
Query: 163 LKWLS-----NFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV-WLQLLRICRVLR 216
+K + + +++ WN+ DF+V +L+ G G+ + ++ LR+ RVLR
Sbjct: 1200 IKMIDLGLLLHPGAYFRDLWNILDFIVVSGALV--AFAFSGSKGKDINTIKSLRVLRVLR 1257
Query: 217 SLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------------- 263
LK + + +++ + +V +LK++ +L++ ++F +IFAV V +F
Sbjct: 1258 PLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKE 1317
Query: 264 --------------SEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKV 309
E PRQ +Y + ++ +L+T+F + T + W +L+
Sbjct: 1318 LERDCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDA 1377
Query: 310 PEVS-------RIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQ----NIRKELNEEMARR 358
R+ SI+++++ ++ F +I VA+++ FQ + E + E R
Sbjct: 1378 TYEEQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKVMSECSLEKNER 1437
Query: 359 ---EVQLKADMFKRQIIQRRKNMSHEALT 384
+ + A R + Q R++ ++ T
Sbjct: 1438 ACIDFAISAKPLTRYMPQNRQSFQYKTWT 1466
Score = 69.7 bits (169), Expect = 6e-12
Identities = 84/396 (21%), Positives = 162/396 (40%), Gaps = 73/396 (18%)
Query: 100 WAGWVLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFIL 159
+A + E P F+ I+ + N I+L +E L + T P+ L+ + + IF
Sbjct: 87 YAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKT---PMSERLDDTEPYFIGIFCF 143
Query: 160 EILLKWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRICRV 214
E +K ++ VF K + WNV DFVV + +L G L+ LR RV
Sbjct: 144 EAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGIL-------ATAGTDFDLRTLRAVRV 196
Query: 215 LRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF----------- 263
LR LKL++ +Q+++ +++A+ + + +LL +FA+ G+ +
Sbjct: 197 LRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPN 256
Query: 264 ---------------------------SEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTL 296
EY P + F ++ +++TVF T+
Sbjct: 257 STDAEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGI---TNFDNILFAILTVFQCITM 313
Query: 297 DHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMA 356
+ W +L + ++ +YFI +++GS ++++ ++ F R+ + A
Sbjct: 314 EGWTDILYNT--NDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRA 371
Query: 357 ----RREVQLKADM--FKRQIIQRRKNMSHEALTSSHSK----IEDRGASQQRESLDLSE 406
RR+ Q++ ++ + I + + M E ++ K + R A+++ + DL
Sbjct: 372 FLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDRNAEEKSPLDVLKRAATKKSRN-DLIH 430
Query: 407 VSEVESNYGATEEDLITSASKTEETLSKKREYQSSS 442
E E + DL S K + +SSS
Sbjct: 431 AEEGEDRFA----DLCAVGSPFARASLKSGKTESSS 462
>gi|20070163 voltage-dependent calcium channel alpha 1G subunit
isoform 1 [Homo sapiens]
Length = 2377
Score = 99.4 bits (246), Expect = 7e-21
Identities = 68/321 (21%), Positives = 162/321 (50%), Gaps = 40/321 (12%)
Query: 109 LFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLK---- 164
+F + ++ ++FLN I + +E ++ + + ++ L ++ + +F+ E+ +K
Sbjct: 1277 MFDHVVLVIIFLNCITIAMERPKIDPHSAE----RIFLTLSNYIFTAVFLAEMTVKVVAL 1332
Query: 165 -WLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV--WLQLLRICRVLRSLKLL 221
W + +S+WNV D ++ ++S++ +V +V +G + L++LR+ R LR L+++
Sbjct: 1333 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1392
Query: 222 AQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------------------ 263
++ + +++++ L+ +LK + ++++ FF IF + GV +F
Sbjct: 1393 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNK 1452
Query: 264 SEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRI-------F 316
S+ + + + + F +L +L+++F+L + D W ++ D V + +
Sbjct: 1453 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1512
Query: 317 SSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADMFKRQIIQRRK 376
+YFI +LL+ + ++ V ++V NF R+ EE ARR + + R++ ++R+
Sbjct: 1513 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL----RRLEKKRR 1568
Query: 377 NMSHEALTSSHSKIEDRGASQ 397
N+ + + +S S +Q
Sbjct: 1569 NLMLDDVIASGSSASAASEAQ 1589
Score = 92.8 bits (229), Expect = 7e-19
Identities = 58/234 (24%), Positives = 123/234 (52%), Gaps = 14/234 (5%)
Query: 146 LEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSL----LPEVVVLVGVT 200
L++ + +IF+LE + K ++ F F++ WN D + +LS+ L E+ V +
Sbjct: 1643 LKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLP 1702
Query: 201 GQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGV 260
++++R+ R+ R LKLL ++ ++ +++AL + L +L ++ F+IFA GV
Sbjct: 1703 INPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGV 1762
Query: 261 YVFSEY---TRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPE-----V 312
+F + P + L H F + + +T+F + T D+W +++D + +
Sbjct: 1763 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1822
Query: 313 SRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADM 366
+ + S IYF+ ++L + ++++A+++ + + KE EE A E +L+ +M
Sbjct: 1823 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE-AELEAELELEM 1875
Score = 88.2 bits (217), Expect = 2e-17
Identities = 76/270 (28%), Positives = 138/270 (51%), Gaps = 21/270 (7%)
Query: 96 PLSLWAGWVLECPLFKNFIIFLVFLNTIILMVEIELLE-STNTKLWPLKLT--LEVAAWF 152
P S+ A W L C F+ + F I++ + + L P +LT LE++
Sbjct: 722 PSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIV 781
Query: 153 ILLIFILEILLKWLSNFSV-FWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRI 211
+F LE+LLK L + K+ +N+FD V+ ++S V +VG G L +LR
Sbjct: 782 FTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVIS----VWEIVGQQGGG--LSVLRT 835
Query: 212 CRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPR 271
R++R LKL+ +Q ++VL++ + ++ MLL++F +IF++ G+++F S R
Sbjct: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASER 895
Query: 272 --QDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGS 329
L F L ++VTVF + T + W +L + + ++++YFI + G+
Sbjct: 896 DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVL---YNGMASTSSWAALYFIALMTFGN 952
Query: 330 IIFRSIIVAMMVTNFQNIRKELNEEMARRE 359
+ +++VA++V FQ EE+++RE
Sbjct: 953 YVLFNLLVAILVEGFQ------AEEISKRE 976
Score = 49.3 bits (116), Expect = 9e-06
Identities = 32/123 (26%), Positives = 63/123 (51%), Gaps = 11/123 (8%)
Query: 152 FILLIFILEILLKWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVVLVGVTGQSVWL 206
FI F +E+++K ++ +F K WN DF + + +L + L Q+V
Sbjct: 123 FIFAFFAVEMVVKMVA-LGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDL-----QNVSF 176
Query: 207 QLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEY 266
+R RVLR L+ + + ++I++ +L+ L + +L+L F+IF + GV +++
Sbjct: 177 SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236
Query: 267 TRS 269
R+
Sbjct: 237 LRN 239
Score = 37.0 bits (84), Expect = 0.045
Identities = 17/82 (20%), Positives = 44/82 (53%), Gaps = 3/82 (3%)
Query: 280 FSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAM 339
F ++ + + +F + TL+ W ++ + V + ++ IYFIL +++GS ++ + +
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIM---YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVV 393
Query: 340 MVTNFQNIRKELNEEMARREVQ 361
+ T F ++ ++ M + V+
Sbjct: 394 IATQFSETKQRESQLMREQRVR 415
>gi|38505284 voltage-dependent calcium channel alpha 1G subunit
isoform 4 [Homo sapiens]
Length = 2332
Score = 99.4 bits (246), Expect = 7e-21
Identities = 68/321 (21%), Positives = 162/321 (50%), Gaps = 40/321 (12%)
Query: 109 LFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLK---- 164
+F + ++ ++FLN I + +E ++ + + ++ L ++ + +F+ E+ +K
Sbjct: 1277 MFDHVVLVIIFLNCITIAMERPKIDPHSAE----RIFLTLSNYIFTAVFLAEMTVKVVAL 1332
Query: 165 -WLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV--WLQLLRICRVLRSLKLL 221
W + +S+WNV D ++ ++S++ +V +V +G + L++LR+ R LR L+++
Sbjct: 1333 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1392
Query: 222 AQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------------------ 263
++ + +++++ L+ +LK + ++++ FF IF + GV +F
Sbjct: 1393 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNK 1452
Query: 264 SEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRI-------F 316
S+ + + + + F +L +L+++F+L + D W ++ D V + +
Sbjct: 1453 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1512
Query: 317 SSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADMFKRQIIQRRK 376
+YFI +LL+ + ++ V ++V NF R+ EE ARR + + R++ ++R+
Sbjct: 1513 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL----RRLEKKRR 1568
Query: 377 NMSHEALTSSHSKIEDRGASQ 397
N+ + + +S S +Q
Sbjct: 1569 NLMLDDVIASGSSASAASEAQ 1589
Score = 92.8 bits (229), Expect = 7e-19
Identities = 58/234 (24%), Positives = 123/234 (52%), Gaps = 14/234 (5%)
Query: 146 LEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSL----LPEVVVLVGVT 200
L++ + +IF+LE + K ++ F F++ WN D + +LS+ L E+ V +
Sbjct: 1643 LKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLP 1702
Query: 201 GQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGV 260
++++R+ R+ R LKLL ++ ++ +++AL + L +L ++ F+IFA GV
Sbjct: 1703 INPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGV 1762
Query: 261 YVFSEY---TRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPE-----V 312
+F + P + L H F + + +T+F + T D+W +++D + +
Sbjct: 1763 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1822
Query: 313 SRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADM 366
+ + S IYF+ ++L + ++++A+++ + + KE EE A E +L+ +M
Sbjct: 1823 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE-AELEAELELEM 1875
Score = 88.2 bits (217), Expect = 2e-17
Identities = 76/270 (28%), Positives = 138/270 (51%), Gaps = 21/270 (7%)
Query: 96 PLSLWAGWVLECPLFKNFIIFLVFLNTIILMVEIELLE-STNTKLWPLKLT--LEVAAWF 152
P S+ A W L C F+ + F I++ + + L P +LT LE++
Sbjct: 722 PSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIV 781
Query: 153 ILLIFILEILLKWLSNFSV-FWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRI 211
+F LE+LLK L + K+ +N+FD V+ ++S V +VG G L +LR
Sbjct: 782 FTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVIS----VWEIVGQQGGG--LSVLRT 835
Query: 212 CRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPR 271
R++R LKL+ +Q ++VL++ + ++ MLL++F +IF++ G+++F S R
Sbjct: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASER 895
Query: 272 --QDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGS 329
L F L ++VTVF + T + W +L + + ++++YFI + G+
Sbjct: 896 DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVL---YNGMASTSSWAALYFIALMTFGN 952
Query: 330 IIFRSIIVAMMVTNFQNIRKELNEEMARRE 359
+ +++VA++V FQ EE+++RE
Sbjct: 953 YVLFNLLVAILVEGFQ------AEEISKRE 976
Score = 49.3 bits (116), Expect = 9e-06
Identities = 32/123 (26%), Positives = 63/123 (51%), Gaps = 11/123 (8%)
Query: 152 FILLIFILEILLKWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVVLVGVTGQSVWL 206
FI F +E+++K ++ +F K WN DF + + +L + L Q+V
Sbjct: 123 FIFAFFAVEMVVKMVA-LGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDL-----QNVSF 176
Query: 207 QLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEY 266
+R RVLR L+ + + ++I++ +L+ L + +L+L F+IF + GV +++
Sbjct: 177 SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236
Query: 267 TRS 269
R+
Sbjct: 237 LRN 239
Score = 37.0 bits (84), Expect = 0.045
Identities = 17/82 (20%), Positives = 44/82 (53%), Gaps = 3/82 (3%)
Query: 280 FSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAM 339
F ++ + + +F + TL+ W ++ + V + ++ IYFIL +++GS ++ + +
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIM---YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVV 393
Query: 340 MVTNFQNIRKELNEEMARREVQ 361
+ T F ++ ++ M + V+
Sbjct: 394 IATQFSETKQRESQLMREQRVR 415
>gi|38505282 voltage-dependent calcium channel alpha 1G subunit
isoform 8 [Homo sapiens]
Length = 2284
Score = 99.4 bits (246), Expect = 7e-21
Identities = 68/321 (21%), Positives = 162/321 (50%), Gaps = 40/321 (12%)
Query: 109 LFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLK---- 164
+F + ++ ++FLN I + +E ++ + + ++ L ++ + +F+ E+ +K
Sbjct: 1277 MFDHVVLVIIFLNCITIAMERPKIDPHSAE----RIFLTLSNYIFTAVFLAEMTVKVVAL 1332
Query: 165 -WLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV--WLQLLRICRVLRSLKLL 221
W + +S+WNV D ++ ++S++ +V +V +G + L++LR+ R LR L+++
Sbjct: 1333 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1392
Query: 222 AQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------------------ 263
++ + +++++ L+ +LK + ++++ FF IF + GV +F
Sbjct: 1393 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNK 1452
Query: 264 SEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRI-------F 316
S+ + + + + F +L +L+++F+L + D W ++ D V + +
Sbjct: 1453 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1512
Query: 317 SSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADMFKRQIIQRRK 376
+YFI +LL+ + ++ V ++V NF R+ EE ARR + + R++ ++R+
Sbjct: 1513 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL----RRLEKKRR 1568
Query: 377 NMSHEALTSSHSKIEDRGASQ 397
N+ + + +S S +Q
Sbjct: 1569 NLMLDDVIASGSSASAASEAQ 1589
Score = 92.8 bits (229), Expect = 7e-19
Identities = 58/234 (24%), Positives = 123/234 (52%), Gaps = 14/234 (5%)
Query: 146 LEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSL----LPEVVVLVGVT 200
L++ + +IF+LE + K ++ F F++ WN D + +LS+ L E+ V +
Sbjct: 1643 LKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLP 1702
Query: 201 GQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGV 260
++++R+ R+ R LKLL ++ ++ +++AL + L +L ++ F+IFA GV
Sbjct: 1703 INPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGV 1762
Query: 261 YVFSEY---TRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPE-----V 312
+F + P + L H F + + +T+F + T D+W +++D + +
Sbjct: 1763 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1822
Query: 313 SRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADM 366
+ + S IYF+ ++L + ++++A+++ + + KE EE A E +L+ +M
Sbjct: 1823 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE-AELEAELELEM 1875
Score = 88.2 bits (217), Expect = 2e-17
Identities = 76/270 (28%), Positives = 138/270 (51%), Gaps = 21/270 (7%)
Query: 96 PLSLWAGWVLECPLFKNFIIFLVFLNTIILMVEIELLE-STNTKLWPLKLT--LEVAAWF 152
P S+ A W L C F+ + F I++ + + L P +LT LE++
Sbjct: 722 PSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIV 781
Query: 153 ILLIFILEILLKWLSNFSV-FWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRI 211
+F LE+LLK L + K+ +N+FD V+ ++S V +VG G L +LR
Sbjct: 782 FTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVIS----VWEIVGQQGGG--LSVLRT 835
Query: 212 CRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPR 271
R++R LKL+ +Q ++VL++ + ++ MLL++F +IF++ G+++F S R
Sbjct: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASER 895
Query: 272 --QDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGS 329
L F L ++VTVF + T + W +L + + ++++YFI + G+
Sbjct: 896 DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVL---YNGMASTSSWAALYFIALMTFGN 952
Query: 330 IIFRSIIVAMMVTNFQNIRKELNEEMARRE 359
+ +++VA++V FQ EE+++RE
Sbjct: 953 YVLFNLLVAILVEGFQ------AEEISKRE 976
Score = 49.3 bits (116), Expect = 9e-06
Identities = 32/123 (26%), Positives = 63/123 (51%), Gaps = 11/123 (8%)
Query: 152 FILLIFILEILLKWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVVLVGVTGQSVWL 206
FI F +E+++K ++ +F K WN DF + + +L + L Q+V
Sbjct: 123 FIFAFFAVEMVVKMVA-LGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDL-----QNVSF 176
Query: 207 QLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEY 266
+R RVLR L+ + + ++I++ +L+ L + +L+L F+IF + GV +++
Sbjct: 177 SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236
Query: 267 TRS 269
R+
Sbjct: 237 LRN 239
Score = 37.0 bits (84), Expect = 0.045
Identities = 17/82 (20%), Positives = 44/82 (53%), Gaps = 3/82 (3%)
Query: 280 FSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAM 339
F ++ + + +F + TL+ W ++ + V + ++ IYFIL +++GS ++ + +
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIM---YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVV 393
Query: 340 MVTNFQNIRKELNEEMARREVQ 361
+ T F ++ ++ M + V+
Sbjct: 394 IATQFSETKQRESQLMREQRVR 415
>gi|38505280 voltage-dependent calcium channel alpha 1G subunit
isoform 6 [Homo sapiens]
Length = 2306
Score = 99.4 bits (246), Expect = 7e-21
Identities = 68/321 (21%), Positives = 162/321 (50%), Gaps = 40/321 (12%)
Query: 109 LFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLK---- 164
+F + ++ ++FLN I + +E ++ + + ++ L ++ + +F+ E+ +K
Sbjct: 1254 MFDHVVLVIIFLNCITIAMERPKIDPHSAE----RIFLTLSNYIFTAVFLAEMTVKVVAL 1309
Query: 165 -WLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV--WLQLLRICRVLRSLKLL 221
W + +S+WNV D ++ ++S++ +V +V +G + L++LR+ R LR L+++
Sbjct: 1310 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1369
Query: 222 AQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------------------ 263
++ + +++++ L+ +LK + ++++ FF IF + GV +F
Sbjct: 1370 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNK 1429
Query: 264 SEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRI-------F 316
S+ + + + + F +L +L+++F+L + D W ++ D V + +
Sbjct: 1430 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1489
Query: 317 SSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADMFKRQIIQRRK 376
+YFI +LL+ + ++ V ++V NF R+ EE ARR + + R++ ++R+
Sbjct: 1490 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL----RRLEKKRR 1545
Query: 377 NMSHEALTSSHSKIEDRGASQ 397
N+ + + +S S +Q
Sbjct: 1546 NLMLDDVIASGSSASAASEAQ 1566
Score = 92.8 bits (229), Expect = 7e-19
Identities = 58/234 (24%), Positives = 123/234 (52%), Gaps = 14/234 (5%)
Query: 146 LEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSL----LPEVVVLVGVT 200
L++ + +IF+LE + K ++ F F++ WN D + +LS+ L E+ V +
Sbjct: 1620 LKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLP 1679
Query: 201 GQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGV 260
++++R+ R+ R LKLL ++ ++ +++AL + L +L ++ F+IFA GV
Sbjct: 1680 INPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGV 1739
Query: 261 YVFSEY---TRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPE-----V 312
+F + P + L H F + + +T+F + T D+W +++D + +
Sbjct: 1740 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1799
Query: 313 SRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADM 366
+ + S IYF+ ++L + ++++A+++ + + KE EE A E +L+ +M
Sbjct: 1800 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE-AELEAELELEM 1852
Score = 86.3 bits (212), Expect = 6e-17
Identities = 72/256 (28%), Positives = 131/256 (51%), Gaps = 15/256 (5%)
Query: 96 PLSLWAGWVLECPLFKNFIIFLVFLNTIILMVEIELLE-STNTKLWPLKLT--LEVAAWF 152
P S+ A W L C F+ + F I++ + + L P +LT LE++
Sbjct: 722 PSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIV 781
Query: 153 ILLIFILEILLKWLSNFSV-FWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRI 211
+F LE+LLK L + K+ +N+FD V+ ++S V +VG G L +LR
Sbjct: 782 FTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVIS----VWEIVGQQGGG--LSVLRT 835
Query: 212 CRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPR 271
R++R LKL+ +Q ++VL++ + ++ MLL++F +IF++ G+++F S R
Sbjct: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASER 895
Query: 272 --QDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGS 329
L F L ++VTVF + T + W +L + + ++++YFI + G+
Sbjct: 896 DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVL---YNGMASTSSWAALYFIALMTFGN 952
Query: 330 IIFRSIIVAMMVTNFQ 345
+ +++VA++V FQ
Sbjct: 953 YVLFNLLVAILVEGFQ 968
Score = 49.3 bits (116), Expect = 9e-06
Identities = 32/123 (26%), Positives = 63/123 (51%), Gaps = 11/123 (8%)
Query: 152 FILLIFILEILLKWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVVLVGVTGQSVWL 206
FI F +E+++K ++ +F K WN DF + + +L + L Q+V
Sbjct: 123 FIFAFFAVEMVVKMVA-LGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDL-----QNVSF 176
Query: 207 QLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEY 266
+R RVLR L+ + + ++I++ +L+ L + +L+L F+IF + GV +++
Sbjct: 177 SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236
Query: 267 TRS 269
R+
Sbjct: 237 LRN 239
Score = 37.0 bits (84), Expect = 0.045
Identities = 17/82 (20%), Positives = 44/82 (53%), Gaps = 3/82 (3%)
Query: 280 FSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAM 339
F ++ + + +F + TL+ W ++ + V + ++ IYFIL +++GS ++ + +
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIM---YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVV 393
Query: 340 MVTNFQNIRKELNEEMARREVQ 361
+ T F ++ ++ M + V+
Sbjct: 394 IATQFSETKQRESQLMREQRVR 415
>gi|38505278 voltage-dependent calcium channel alpha 1G subunit
isoform 11 [Homo sapiens]
Length = 2261
Score = 99.4 bits (246), Expect = 7e-21
Identities = 68/321 (21%), Positives = 162/321 (50%), Gaps = 40/321 (12%)
Query: 109 LFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLK---- 164
+F + ++ ++FLN I + +E ++ + + ++ L ++ + +F+ E+ +K
Sbjct: 1254 MFDHVVLVIIFLNCITIAMERPKIDPHSAE----RIFLTLSNYIFTAVFLAEMTVKVVAL 1309
Query: 165 -WLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV--WLQLLRICRVLRSLKLL 221
W + +S+WNV D ++ ++S++ +V +V +G + L++LR+ R LR L+++
Sbjct: 1310 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1369
Query: 222 AQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------------------ 263
++ + +++++ L+ +LK + ++++ FF IF + GV +F
Sbjct: 1370 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNK 1429
Query: 264 SEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRI-------F 316
S+ + + + + F +L +L+++F+L + D W ++ D V + +
Sbjct: 1430 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1489
Query: 317 SSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADMFKRQIIQRRK 376
+YFI +LL+ + ++ V ++V NF R+ EE ARR + + R++ ++R+
Sbjct: 1490 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL----RRLEKKRR 1545
Query: 377 NMSHEALTSSHSKIEDRGASQ 397
N+ + + +S S +Q
Sbjct: 1546 NLMLDDVIASGSSASAASEAQ 1566
Score = 92.8 bits (229), Expect = 7e-19
Identities = 58/234 (24%), Positives = 123/234 (52%), Gaps = 14/234 (5%)
Query: 146 LEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSL----LPEVVVLVGVT 200
L++ + +IF+LE + K ++ F F++ WN D + +LS+ L E+ V +
Sbjct: 1620 LKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLP 1679
Query: 201 GQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGV 260
++++R+ R+ R LKLL ++ ++ +++AL + L +L ++ F+IFA GV
Sbjct: 1680 INPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGV 1739
Query: 261 YVFSEY---TRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPE-----V 312
+F + P + L H F + + +T+F + T D+W +++D + +
Sbjct: 1740 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1799
Query: 313 SRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADM 366
+ + S IYF+ ++L + ++++A+++ + + KE EE A E +L+ +M
Sbjct: 1800 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE-AELEAELELEM 1852
Score = 86.3 bits (212), Expect = 6e-17
Identities = 72/256 (28%), Positives = 131/256 (51%), Gaps = 15/256 (5%)
Query: 96 PLSLWAGWVLECPLFKNFIIFLVFLNTIILMVEIELLE-STNTKLWPLKLT--LEVAAWF 152
P S+ A W L C F+ + F I++ + + L P +LT LE++
Sbjct: 722 PSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIV 781
Query: 153 ILLIFILEILLKWLSNFSV-FWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRI 211
+F LE+LLK L + K+ +N+FD V+ ++S V +VG G L +LR
Sbjct: 782 FTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVIS----VWEIVGQQGGG--LSVLRT 835
Query: 212 CRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPR 271
R++R LKL+ +Q ++VL++ + ++ MLL++F +IF++ G+++F S R
Sbjct: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASER 895
Query: 272 --QDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGS 329
L F L ++VTVF + T + W +L + + ++++YFI + G+
Sbjct: 896 DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVL---YNGMASTSSWAALYFIALMTFGN 952
Query: 330 IIFRSIIVAMMVTNFQ 345
+ +++VA++V FQ
Sbjct: 953 YVLFNLLVAILVEGFQ 968
Score = 49.3 bits (116), Expect = 9e-06
Identities = 32/123 (26%), Positives = 63/123 (51%), Gaps = 11/123 (8%)
Query: 152 FILLIFILEILLKWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVVLVGVTGQSVWL 206
FI F +E+++K ++ +F K WN DF + + +L + L Q+V
Sbjct: 123 FIFAFFAVEMVVKMVA-LGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDL-----QNVSF 176
Query: 207 QLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEY 266
+R RVLR L+ + + ++I++ +L+ L + +L+L F+IF + GV +++
Sbjct: 177 SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236
Query: 267 TRS 269
R+
Sbjct: 237 LRN 239
Score = 37.0 bits (84), Expect = 0.045
Identities = 17/82 (20%), Positives = 44/82 (53%), Gaps = 3/82 (3%)
Query: 280 FSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAM 339
F ++ + + +F + TL+ W ++ + V + ++ IYFIL +++GS ++ + +
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIM---YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVV 393
Query: 340 MVTNFQNIRKELNEEMARREVQ 361
+ T F ++ ++ M + V+
Sbjct: 394 IATQFSETKQRESQLMREQRVR 415
>gi|38505270 voltage-dependent calcium channel alpha 1G subunit
isoform 2 [Homo sapiens]
Length = 2354
Score = 99.4 bits (246), Expect = 7e-21
Identities = 68/321 (21%), Positives = 162/321 (50%), Gaps = 40/321 (12%)
Query: 109 LFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLK---- 164
+F + ++ ++FLN I + +E ++ + + ++ L ++ + +F+ E+ +K
Sbjct: 1254 MFDHVVLVIIFLNCITIAMERPKIDPHSAE----RIFLTLSNYIFTAVFLAEMTVKVVAL 1309
Query: 165 -WLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV--WLQLLRICRVLRSLKLL 221
W + +S+WNV D ++ ++S++ +V +V +G + L++LR+ R LR L+++
Sbjct: 1310 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1369
Query: 222 AQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------------------ 263
++ + +++++ L+ +LK + ++++ FF IF + GV +F
Sbjct: 1370 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNK 1429
Query: 264 SEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRI-------F 316
S+ + + + + F +L +L+++F+L + D W ++ D V + +
Sbjct: 1430 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1489
Query: 317 SSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADMFKRQIIQRRK 376
+YFI +LL+ + ++ V ++V NF R+ EE ARR + + R++ ++R+
Sbjct: 1490 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL----RRLEKKRR 1545
Query: 377 NMSHEALTSSHSKIEDRGASQ 397
N+ + + +S S +Q
Sbjct: 1546 NLMLDDVIASGSSASAASEAQ 1566
Score = 92.8 bits (229), Expect = 7e-19
Identities = 58/234 (24%), Positives = 123/234 (52%), Gaps = 14/234 (5%)
Query: 146 LEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSL----LPEVVVLVGVT 200
L++ + +IF+LE + K ++ F F++ WN D + +LS+ L E+ V +
Sbjct: 1620 LKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLP 1679
Query: 201 GQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGV 260
++++R+ R+ R LKLL ++ ++ +++AL + L +L ++ F+IFA GV
Sbjct: 1680 INPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGV 1739
Query: 261 YVFSEY---TRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPE-----V 312
+F + P + L H F + + +T+F + T D+W +++D + +
Sbjct: 1740 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1799
Query: 313 SRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADM 366
+ + S IYF+ ++L + ++++A+++ + + KE EE A E +L+ +M
Sbjct: 1800 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE-AELEAELELEM 1852
Score = 86.3 bits (212), Expect = 6e-17
Identities = 72/256 (28%), Positives = 131/256 (51%), Gaps = 15/256 (5%)
Query: 96 PLSLWAGWVLECPLFKNFIIFLVFLNTIILMVEIELLE-STNTKLWPLKLT--LEVAAWF 152
P S+ A W L C F+ + F I++ + + L P +LT LE++
Sbjct: 722 PSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIV 781
Query: 153 ILLIFILEILLKWLSNFSV-FWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRI 211
+F LE+LLK L + K+ +N+FD V+ ++S V +VG G L +LR
Sbjct: 782 FTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVIS----VWEIVGQQGGG--LSVLRT 835
Query: 212 CRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPR 271
R++R LKL+ +Q ++VL++ + ++ MLL++F +IF++ G+++F S R
Sbjct: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASER 895
Query: 272 --QDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGS 329
L F L ++VTVF + T + W +L + + ++++YFI + G+
Sbjct: 896 DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVL---YNGMASTSSWAALYFIALMTFGN 952
Query: 330 IIFRSIIVAMMVTNFQ 345
+ +++VA++V FQ
Sbjct: 953 YVLFNLLVAILVEGFQ 968
Score = 49.3 bits (116), Expect = 9e-06
Identities = 32/123 (26%), Positives = 63/123 (51%), Gaps = 11/123 (8%)
Query: 152 FILLIFILEILLKWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVVLVGVTGQSVWL 206
FI F +E+++K ++ +F K WN DF + + +L + L Q+V
Sbjct: 123 FIFAFFAVEMVVKMVA-LGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDL-----QNVSF 176
Query: 207 QLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEY 266
+R RVLR L+ + + ++I++ +L+ L + +L+L F+IF + GV +++
Sbjct: 177 SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236
Query: 267 TRS 269
R+
Sbjct: 237 LRN 239
Score = 37.0 bits (84), Expect = 0.045
Identities = 17/82 (20%), Positives = 44/82 (53%), Gaps = 3/82 (3%)
Query: 280 FSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAM 339
F ++ + + +F + TL+ W ++ + V + ++ IYFIL +++GS ++ + +
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIM---YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVV 393
Query: 340 MVTNFQNIRKELNEEMARREVQ 361
+ T F ++ ++ M + V+
Sbjct: 394 IATQFSETKQRESQLMREQRVR 415
>gi|62988334 cation channel, sperm associated 4 [Homo sapiens]
Length = 472
Score = 98.2 bits (243), Expect = 2e-20
Identities = 64/248 (25%), Positives = 126/248 (50%), Gaps = 22/248 (8%)
Query: 104 VLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILL 163
+L P F+ + L+ +N I + + + K + L T++ +L I + E+LL
Sbjct: 88 LLRHPAFQLLLALLLVINAITIALRTN--SYLDQKHYELFSTIDD---IVLTILLCEVLL 142
Query: 164 KWLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRICRVLRSLKLLAQ 223
WL+ F +FWK WN+ +F++ + LL + + + + L+ LR+ V +++ LA+
Sbjct: 143 GWLNGFWIFWKDGWNILNFIIVFILLLRFFINEINIPSINYTLRALRLVHVCMAVEPLAR 202
Query: 224 FRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHVFFSDL 283
II V+++++ M +++L+L F +F+V GV +F + P+ F ++
Sbjct: 203 ------IIRVILQSVPDMANIMVLILFFMLVFSVFGVTLFGAFV--PKH-------FQNI 247
Query: 284 PNSLVTVFILFTLDHWYALLQD--VWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMV 341
+L T+FI T D W + D K I +IYF +++ +G+ I ++ V ++
Sbjct: 248 QVALYTLFICITQDGWVDIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGINLFVIVVT 307
Query: 342 TNFQNIRK 349
TN + + K
Sbjct: 308 TNLEQMMK 315
>gi|38505292 voltage-dependent calcium channel alpha 1G subunit
isoform 3 [Homo sapiens]
Length = 2343
Score = 97.8 bits (242), Expect = 2e-20
Identities = 64/303 (21%), Positives = 153/303 (50%), Gaps = 36/303 (11%)
Query: 109 LFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLK---- 164
+F + ++ ++FLN I + +E ++ + + ++ L ++ + +F+ E+ +K
Sbjct: 1254 MFDHVVLVIIFLNCITIAMERPKIDPHSAE----RIFLTLSNYIFTAVFLAEMTVKVVAL 1309
Query: 165 -WLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV--WLQLLRICRVLRSLKLL 221
W + +S+WNV D ++ ++S++ +V +V +G + L++LR+ R LR L+++
Sbjct: 1310 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1369
Query: 222 AQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------------------ 263
++ + +++++ L+ +LK + ++++ FF IF + GV +F
Sbjct: 1370 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNK 1429
Query: 264 SEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRI-------F 316
S+ + + + + F +L +L+++F+L + D W ++ D V + +
Sbjct: 1430 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1489
Query: 317 SSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADMFKRQIIQRRK 376
+YFI +LL+ + ++ V ++V NF R+ EE ARR + + +++ + K
Sbjct: 1490 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRSKEK 1549
Query: 377 NMS 379
M+
Sbjct: 1550 QMA 1552
Score = 92.8 bits (229), Expect = 7e-19
Identities = 58/234 (24%), Positives = 123/234 (52%), Gaps = 14/234 (5%)
Query: 146 LEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSL----LPEVVVLVGVT 200
L++ + +IF+LE + K ++ F F++ WN D + +LS+ L E+ V +
Sbjct: 1609 LKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLP 1668
Query: 201 GQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGV 260
++++R+ R+ R LKLL ++ ++ +++AL + L +L ++ F+IFA GV
Sbjct: 1669 INPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGV 1728
Query: 261 YVFSEY---TRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPE-----V 312
+F + P + L H F + + +T+F + T D+W +++D + +
Sbjct: 1729 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1788
Query: 313 SRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADM 366
+ + S IYF+ ++L + ++++A+++ + + KE EE A E +L+ +M
Sbjct: 1789 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE-AELEAELELEM 1841
Score = 86.3 bits (212), Expect = 6e-17
Identities = 72/256 (28%), Positives = 131/256 (51%), Gaps = 15/256 (5%)
Query: 96 PLSLWAGWVLECPLFKNFIIFLVFLNTIILMVEIELLE-STNTKLWPLKLT--LEVAAWF 152
P S+ A W L C F+ + F I++ + + L P +LT LE++
Sbjct: 722 PSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIV 781
Query: 153 ILLIFILEILLKWLSNFSV-FWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRI 211
+F LE+LLK L + K+ +N+FD V+ ++S V +VG G L +LR
Sbjct: 782 FTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVIS----VWEIVGQQGGG--LSVLRT 835
Query: 212 CRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPR 271
R++R LKL+ +Q ++VL++ + ++ MLL++F +IF++ G+++F S R
Sbjct: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASER 895
Query: 272 --QDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGS 329
L F L ++VTVF + T + W +L + + ++++YFI + G+
Sbjct: 896 DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVL---YNGMASTSSWAALYFIALMTFGN 952
Query: 330 IIFRSIIVAMMVTNFQ 345
+ +++VA++V FQ
Sbjct: 953 YVLFNLLVAILVEGFQ 968
Score = 49.3 bits (116), Expect = 9e-06
Identities = 32/123 (26%), Positives = 63/123 (51%), Gaps = 11/123 (8%)
Query: 152 FILLIFILEILLKWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVVLVGVTGQSVWL 206
FI F +E+++K ++ +F K WN DF + + +L + L Q+V
Sbjct: 123 FIFAFFAVEMVVKMVA-LGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDL-----QNVSF 176
Query: 207 QLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEY 266
+R RVLR L+ + + ++I++ +L+ L + +L+L F+IF + GV +++
Sbjct: 177 SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236
Query: 267 TRS 269
R+
Sbjct: 237 LRN 239
Score = 37.0 bits (84), Expect = 0.045
Identities = 17/82 (20%), Positives = 44/82 (53%), Gaps = 3/82 (3%)
Query: 280 FSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAM 339
F ++ + + +F + TL+ W ++ + V + ++ IYFIL +++GS ++ + +
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIM---YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVV 393
Query: 340 MVTNFQNIRKELNEEMARREVQ 361
+ T F ++ ++ M + V+
Sbjct: 394 IATQFSETKQRESQLMREQRVR 415
>gi|38505288 voltage-dependent calcium channel alpha 1G subunit
isoform 12 [Homo sapiens]
Length = 2250
Score = 97.8 bits (242), Expect = 2e-20
Identities = 64/303 (21%), Positives = 153/303 (50%), Gaps = 36/303 (11%)
Query: 109 LFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLK---- 164
+F + ++ ++FLN I + +E ++ + + ++ L ++ + +F+ E+ +K
Sbjct: 1254 MFDHVVLVIIFLNCITIAMERPKIDPHSAE----RIFLTLSNYIFTAVFLAEMTVKVVAL 1309
Query: 165 -WLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV--WLQLLRICRVLRSLKLL 221
W + +S+WNV D ++ ++S++ +V +V +G + L++LR+ R LR L+++
Sbjct: 1310 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1369
Query: 222 AQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------------------ 263
++ + +++++ L+ +LK + ++++ FF IF + GV +F
Sbjct: 1370 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNK 1429
Query: 264 SEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRI-------F 316
S+ + + + + F +L +L+++F+L + D W ++ D V + +
Sbjct: 1430 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1489
Query: 317 SSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADMFKRQIIQRRK 376
+YFI +LL+ + ++ V ++V NF R+ EE ARR + + +++ + K
Sbjct: 1490 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRSKEK 1549
Query: 377 NMS 379
M+
Sbjct: 1550 QMA 1552
Score = 92.8 bits (229), Expect = 7e-19
Identities = 58/234 (24%), Positives = 123/234 (52%), Gaps = 14/234 (5%)
Query: 146 LEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSL----LPEVVVLVGVT 200
L++ + +IF+LE + K ++ F F++ WN D + +LS+ L E+ V +
Sbjct: 1609 LKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLP 1668
Query: 201 GQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGV 260
++++R+ R+ R LKLL ++ ++ +++AL + L +L ++ F+IFA GV
Sbjct: 1669 INPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGV 1728
Query: 261 YVFSEY---TRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPE-----V 312
+F + P + L H F + + +T+F + T D+W +++D + +
Sbjct: 1729 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1788
Query: 313 SRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADM 366
+ + S IYF+ ++L + ++++A+++ + + KE EE A E +L+ +M
Sbjct: 1789 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE-AELEAELELEM 1841
Score = 86.3 bits (212), Expect = 6e-17
Identities = 72/256 (28%), Positives = 131/256 (51%), Gaps = 15/256 (5%)
Query: 96 PLSLWAGWVLECPLFKNFIIFLVFLNTIILMVEIELLE-STNTKLWPLKLT--LEVAAWF 152
P S+ A W L C F+ + F I++ + + L P +LT LE++
Sbjct: 722 PSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIV 781
Query: 153 ILLIFILEILLKWLSNFSV-FWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRI 211
+F LE+LLK L + K+ +N+FD V+ ++S V +VG G L +LR
Sbjct: 782 FTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVIS----VWEIVGQQGGG--LSVLRT 835
Query: 212 CRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPR 271
R++R LKL+ +Q ++VL++ + ++ MLL++F +IF++ G+++F S R
Sbjct: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASER 895
Query: 272 --QDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGS 329
L F L ++VTVF + T + W +L + + ++++YFI + G+
Sbjct: 896 DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVL---YNGMASTSSWAALYFIALMTFGN 952
Query: 330 IIFRSIIVAMMVTNFQ 345
+ +++VA++V FQ
Sbjct: 953 YVLFNLLVAILVEGFQ 968
Score = 49.3 bits (116), Expect = 9e-06
Identities = 32/123 (26%), Positives = 63/123 (51%), Gaps = 11/123 (8%)
Query: 152 FILLIFILEILLKWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVVLVGVTGQSVWL 206
FI F +E+++K ++ +F K WN DF + + +L + L Q+V
Sbjct: 123 FIFAFFAVEMVVKMVA-LGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDL-----QNVSF 176
Query: 207 QLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEY 266
+R RVLR L+ + + ++I++ +L+ L + +L+L F+IF + GV +++
Sbjct: 177 SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236
Query: 267 TRS 269
R+
Sbjct: 237 LRN 239
Score = 37.0 bits (84), Expect = 0.045
Identities = 17/82 (20%), Positives = 44/82 (53%), Gaps = 3/82 (3%)
Query: 280 FSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAM 339
F ++ + + +F + TL+ W ++ + V + ++ IYFIL +++GS ++ + +
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIM---YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVV 393
Query: 340 MVTNFQNIRKELNEEMARREVQ 361
+ T F ++ ++ M + V+
Sbjct: 394 IATQFSETKQRESQLMREQRVR 415
>gi|38505276 voltage-dependent calcium channel alpha 1G subunit
isoform 5 [Homo sapiens]
Length = 2321
Score = 97.8 bits (242), Expect = 2e-20
Identities = 64/303 (21%), Positives = 153/303 (50%), Gaps = 36/303 (11%)
Query: 109 LFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLK---- 164
+F + ++ ++FLN I + +E ++ + + ++ L ++ + +F+ E+ +K
Sbjct: 1277 MFDHVVLVIIFLNCITIAMERPKIDPHSAE----RIFLTLSNYIFTAVFLAEMTVKVVAL 1332
Query: 165 -WLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV--WLQLLRICRVLRSLKLL 221
W + +S+WNV D ++ ++S++ +V +V +G + L++LR+ R LR L+++
Sbjct: 1333 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1392
Query: 222 AQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------------------ 263
++ + +++++ L+ +LK + ++++ FF IF + GV +F
Sbjct: 1393 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNK 1452
Query: 264 SEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRI-------F 316
S+ + + + + F +L +L+++F+L + D W ++ D V + +
Sbjct: 1453 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1512
Query: 317 SSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADMFKRQIIQRRK 376
+YFI +LL+ + ++ V ++V NF R+ EE ARR + + +++ + K
Sbjct: 1513 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRSKEK 1572
Query: 377 NMS 379
M+
Sbjct: 1573 QMA 1575
Score = 92.8 bits (229), Expect = 7e-19
Identities = 58/234 (24%), Positives = 123/234 (52%), Gaps = 14/234 (5%)
Query: 146 LEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSL----LPEVVVLVGVT 200
L++ + +IF+LE + K ++ F F++ WN D + +LS+ L E+ V +
Sbjct: 1632 LKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLP 1691
Query: 201 GQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGV 260
++++R+ R+ R LKLL ++ ++ +++AL + L +L ++ F+IFA GV
Sbjct: 1692 INPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGV 1751
Query: 261 YVFSEY---TRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPE-----V 312
+F + P + L H F + + +T+F + T D+W +++D + +
Sbjct: 1752 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1811
Query: 313 SRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADM 366
+ + S IYF+ ++L + ++++A+++ + + KE EE A E +L+ +M
Sbjct: 1812 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE-AELEAELELEM 1864
Score = 88.2 bits (217), Expect = 2e-17
Identities = 76/270 (28%), Positives = 138/270 (51%), Gaps = 21/270 (7%)
Query: 96 PLSLWAGWVLECPLFKNFIIFLVFLNTIILMVEIELLE-STNTKLWPLKLT--LEVAAWF 152
P S+ A W L C F+ + F I++ + + L P +LT LE++
Sbjct: 722 PSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIV 781
Query: 153 ILLIFILEILLKWLSNFSV-FWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRI 211
+F LE+LLK L + K+ +N+FD V+ ++S V +VG G L +LR
Sbjct: 782 FTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVIS----VWEIVGQQGGG--LSVLRT 835
Query: 212 CRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPR 271
R++R LKL+ +Q ++VL++ + ++ MLL++F +IF++ G+++F S R
Sbjct: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASER 895
Query: 272 --QDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGS 329
L F L ++VTVF + T + W +L + + ++++YFI + G+
Sbjct: 896 DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVL---YNGMASTSSWAALYFIALMTFGN 952
Query: 330 IIFRSIIVAMMVTNFQNIRKELNEEMARRE 359
+ +++VA++V FQ EE+++RE
Sbjct: 953 YVLFNLLVAILVEGFQ------AEEISKRE 976
Score = 49.3 bits (116), Expect = 9e-06
Identities = 32/123 (26%), Positives = 63/123 (51%), Gaps = 11/123 (8%)
Query: 152 FILLIFILEILLKWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVVLVGVTGQSVWL 206
FI F +E+++K ++ +F K WN DF + + +L + L Q+V
Sbjct: 123 FIFAFFAVEMVVKMVA-LGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDL-----QNVSF 176
Query: 207 QLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEY 266
+R RVLR L+ + + ++I++ +L+ L + +L+L F+IF + GV +++
Sbjct: 177 SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236
Query: 267 TRS 269
R+
Sbjct: 237 LRN 239
Score = 37.0 bits (84), Expect = 0.045
Identities = 17/82 (20%), Positives = 44/82 (53%), Gaps = 3/82 (3%)
Query: 280 FSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAM 339
F ++ + + +F + TL+ W ++ + V + ++ IYFIL +++GS ++ + +
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIM---YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVV 393
Query: 340 MVTNFQNIRKELNEEMARREVQ 361
+ T F ++ ++ M + V+
Sbjct: 394 IATQFSETKQRESQLMREQRVR 415
>gi|38505274 voltage-dependent calcium channel alpha 1G subunit
isoform 7 [Homo sapiens]
Length = 2298
Score = 97.8 bits (242), Expect = 2e-20
Identities = 64/303 (21%), Positives = 153/303 (50%), Gaps = 36/303 (11%)
Query: 109 LFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLK---- 164
+F + ++ ++FLN I + +E ++ + + ++ L ++ + +F+ E+ +K
Sbjct: 1254 MFDHVVLVIIFLNCITIAMERPKIDPHSAE----RIFLTLSNYIFTAVFLAEMTVKVVAL 1309
Query: 165 -WLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV--WLQLLRICRVLRSLKLL 221
W + +S+WNV D ++ ++S++ +V +V +G + L++LR+ R LR L+++
Sbjct: 1310 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1369
Query: 222 AQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------------------ 263
++ + +++++ L+ +LK + ++++ FF IF + GV +F
Sbjct: 1370 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNK 1429
Query: 264 SEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRI-------F 316
S+ + + + + F +L +L+++F+L + D W ++ D V + +
Sbjct: 1430 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1489
Query: 317 SSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADMFKRQIIQRRK 376
+YFI +LL+ + ++ V ++V NF R+ EE ARR + + +++ + K
Sbjct: 1490 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRSKEK 1549
Query: 377 NMS 379
M+
Sbjct: 1550 QMA 1552
Score = 92.8 bits (229), Expect = 7e-19
Identities = 58/234 (24%), Positives = 123/234 (52%), Gaps = 14/234 (5%)
Query: 146 LEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSL----LPEVVVLVGVT 200
L++ + +IF+LE + K ++ F F++ WN D + +LS+ L E+ V +
Sbjct: 1609 LKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLP 1668
Query: 201 GQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGV 260
++++R+ R+ R LKLL ++ ++ +++AL + L +L ++ F+IFA GV
Sbjct: 1669 INPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGV 1728
Query: 261 YVFSEY---TRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPE-----V 312
+F + P + L H F + + +T+F + T D+W +++D + +
Sbjct: 1729 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1788
Query: 313 SRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADM 366
+ + S IYF+ ++L + ++++A+++ + + KE EE A E +L+ +M
Sbjct: 1789 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE-AELEAELELEM 1841
Score = 86.3 bits (212), Expect = 6e-17
Identities = 72/256 (28%), Positives = 131/256 (51%), Gaps = 15/256 (5%)
Query: 96 PLSLWAGWVLECPLFKNFIIFLVFLNTIILMVEIELLE-STNTKLWPLKLT--LEVAAWF 152
P S+ A W L C F+ + F I++ + + L P +LT LE++
Sbjct: 722 PSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIV 781
Query: 153 ILLIFILEILLKWLSNFSV-FWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRI 211
+F LE+LLK L + K+ +N+FD V+ ++S V +VG G L +LR
Sbjct: 782 FTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVIS----VWEIVGQQGGG--LSVLRT 835
Query: 212 CRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPR 271
R++R LKL+ +Q ++VL++ + ++ MLL++F +IF++ G+++F S R
Sbjct: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASER 895
Query: 272 --QDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGS 329
L F L ++VTVF + T + W +L + + ++++YFI + G+
Sbjct: 896 DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVL---YNGMASTSSWAALYFIALMTFGN 952
Query: 330 IIFRSIIVAMMVTNFQ 345
+ +++VA++V FQ
Sbjct: 953 YVLFNLLVAILVEGFQ 968
Score = 49.3 bits (116), Expect = 9e-06
Identities = 32/123 (26%), Positives = 63/123 (51%), Gaps = 11/123 (8%)
Query: 152 FILLIFILEILLKWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVVLVGVTGQSVWL 206
FI F +E+++K ++ +F K WN DF + + +L + L Q+V
Sbjct: 123 FIFAFFAVEMVVKMVA-LGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDL-----QNVSF 176
Query: 207 QLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEY 266
+R RVLR L+ + + ++I++ +L+ L + +L+L F+IF + GV +++
Sbjct: 177 SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236
Query: 267 TRS 269
R+
Sbjct: 237 LRN 239
Score = 37.0 bits (84), Expect = 0.045
Identities = 17/82 (20%), Positives = 44/82 (53%), Gaps = 3/82 (3%)
Query: 280 FSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAM 339
F ++ + + +F + TL+ W ++ + V + ++ IYFIL +++GS ++ + +
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIM---YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVV 393
Query: 340 MVTNFQNIRKELNEEMARREVQ 361
+ T F ++ ++ M + V+
Sbjct: 394 IATQFSETKQRESQLMREQRVR 415
>gi|38505272 voltage-dependent calcium channel alpha 1G subunit
isoform 9 [Homo sapiens]
Length = 2273
Score = 97.8 bits (242), Expect = 2e-20
Identities = 64/303 (21%), Positives = 153/303 (50%), Gaps = 36/303 (11%)
Query: 109 LFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLK---- 164
+F + ++ ++FLN I + +E ++ + + ++ L ++ + +F+ E+ +K
Sbjct: 1277 MFDHVVLVIIFLNCITIAMERPKIDPHSAE----RIFLTLSNYIFTAVFLAEMTVKVVAL 1332
Query: 165 -WLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV--WLQLLRICRVLRSLKLL 221
W + +S+WNV D ++ ++S++ +V +V +G + L++LR+ R LR L+++
Sbjct: 1333 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1392
Query: 222 AQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------------------ 263
++ + +++++ L+ +LK + ++++ FF IF + GV +F
Sbjct: 1393 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNK 1452
Query: 264 SEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRI-------F 316
S+ + + + + F +L +L+++F+L + D W ++ D V + +
Sbjct: 1453 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1512
Query: 317 SSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADMFKRQIIQRRK 376
+YFI +LL+ + ++ V ++V NF R+ EE ARR + + +++ + K
Sbjct: 1513 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRSKEK 1572
Query: 377 NMS 379
M+
Sbjct: 1573 QMA 1575
Score = 92.8 bits (229), Expect = 7e-19
Identities = 58/234 (24%), Positives = 123/234 (52%), Gaps = 14/234 (5%)
Query: 146 LEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSL----LPEVVVLVGVT 200
L++ + +IF+LE + K ++ F F++ WN D + +LS+ L E+ V +
Sbjct: 1632 LKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLP 1691
Query: 201 GQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGV 260
++++R+ R+ R LKLL ++ ++ +++AL + L +L ++ F+IFA GV
Sbjct: 1692 INPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGV 1751
Query: 261 YVFSEY---TRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPE-----V 312
+F + P + L H F + + +T+F + T D+W +++D + +
Sbjct: 1752 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1811
Query: 313 SRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADM 366
+ + S IYF+ ++L + ++++A+++ + + KE EE A E +L+ +M
Sbjct: 1812 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE-AELEAELELEM 1864
Score = 88.2 bits (217), Expect = 2e-17
Identities = 76/270 (28%), Positives = 138/270 (51%), Gaps = 21/270 (7%)
Query: 96 PLSLWAGWVLECPLFKNFIIFLVFLNTIILMVEIELLE-STNTKLWPLKLT--LEVAAWF 152
P S+ A W L C F+ + F I++ + + L P +LT LE++
Sbjct: 722 PSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIV 781
Query: 153 ILLIFILEILLKWLSNFSV-FWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRI 211
+F LE+LLK L + K+ +N+FD V+ ++S V +VG G L +LR
Sbjct: 782 FTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVIS----VWEIVGQQGGG--LSVLRT 835
Query: 212 CRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPR 271
R++R LKL+ +Q ++VL++ + ++ MLL++F +IF++ G+++F S R
Sbjct: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASER 895
Query: 272 --QDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGS 329
L F L ++VTVF + T + W +L + + ++++YFI + G+
Sbjct: 896 DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVL---YNGMASTSSWAALYFIALMTFGN 952
Query: 330 IIFRSIIVAMMVTNFQNIRKELNEEMARRE 359
+ +++VA++V FQ EE+++RE
Sbjct: 953 YVLFNLLVAILVEGFQ------AEEISKRE 976
Score = 49.3 bits (116), Expect = 9e-06
Identities = 32/123 (26%), Positives = 63/123 (51%), Gaps = 11/123 (8%)
Query: 152 FILLIFILEILLKWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVVLVGVTGQSVWL 206
FI F +E+++K ++ +F K WN DF + + +L + L Q+V
Sbjct: 123 FIFAFFAVEMVVKMVA-LGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDL-----QNVSF 176
Query: 207 QLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEY 266
+R RVLR L+ + + ++I++ +L+ L + +L+L F+IF + GV +++
Sbjct: 177 SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236
Query: 267 TRS 269
R+
Sbjct: 237 LRN 239
Score = 37.0 bits (84), Expect = 0.045
Identities = 17/82 (20%), Positives = 44/82 (53%), Gaps = 3/82 (3%)
Query: 280 FSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAM 339
F ++ + + +F + TL+ W ++ + V + ++ IYFIL +++GS ++ + +
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIM---YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVV 393
Query: 340 MVTNFQNIRKELNEEMARREVQ 361
+ T F ++ ++ M + V+
Sbjct: 394 IATQFSETKQRESQLMREQRVR 415
>gi|38505268 voltage-dependent calcium channel alpha 1G subunit
isoform 14 [Homo sapiens]
Length = 2171
Score = 97.8 bits (242), Expect = 2e-20
Identities = 64/303 (21%), Positives = 153/303 (50%), Gaps = 36/303 (11%)
Query: 109 LFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLK---- 164
+F + ++ ++FLN I + +E ++ + + ++ L ++ + +F+ E+ +K
Sbjct: 1254 MFDHVVLVIIFLNCITIAMERPKIDPHSAE----RIFLTLSNYIFTAVFLAEMTVKVVAL 1309
Query: 165 -WLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV--WLQLLRICRVLRSLKLL 221
W + +S+WNV D ++ ++S++ +V +V +G + L++LR+ R LR L+++
Sbjct: 1310 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1369
Query: 222 AQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------------------ 263
++ + +++++ L+ +LK + ++++ FF IF + GV +F
Sbjct: 1370 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNK 1429
Query: 264 SEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRI-------F 316
S+ + + + + F +L +L+++F+L + D W ++ D V + +
Sbjct: 1430 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1489
Query: 317 SSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADMFKRQIIQRRK 376
+YFI +LL+ + ++ V ++V NF R+ EE ARR + + +++ + K
Sbjct: 1490 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRSKEK 1549
Query: 377 NMS 379
M+
Sbjct: 1550 QMA 1552
Score = 92.8 bits (229), Expect = 7e-19
Identities = 58/234 (24%), Positives = 123/234 (52%), Gaps = 14/234 (5%)
Query: 146 LEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSL----LPEVVVLVGVT 200
L++ + +IF+LE + K ++ F F++ WN D + +LS+ L E+ V +
Sbjct: 1609 LKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLP 1668
Query: 201 GQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGV 260
++++R+ R+ R LKLL ++ ++ +++AL + L +L ++ F+IFA GV
Sbjct: 1669 INPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGV 1728
Query: 261 YVFSEY---TRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPE-----V 312
+F + P + L H F + + +T+F + T D+W +++D + +
Sbjct: 1729 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1788
Query: 313 SRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADM 366
+ + S IYF+ ++L + ++++A+++ + + KE EE A E +L+ +M
Sbjct: 1789 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE-AELEAELELEM 1841
Score = 86.3 bits (212), Expect = 6e-17
Identities = 72/256 (28%), Positives = 131/256 (51%), Gaps = 15/256 (5%)
Query: 96 PLSLWAGWVLECPLFKNFIIFLVFLNTIILMVEIELLE-STNTKLWPLKLT--LEVAAWF 152
P S+ A W L C F+ + F I++ + + L P +LT LE++
Sbjct: 722 PSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIV 781
Query: 153 ILLIFILEILLKWLSNFSV-FWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRI 211
+F LE+LLK L + K+ +N+FD V+ ++S V +VG G L +LR
Sbjct: 782 FTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVIS----VWEIVGQQGGG--LSVLRT 835
Query: 212 CRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPR 271
R++R LKL+ +Q ++VL++ + ++ MLL++F +IF++ G+++F S R
Sbjct: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASER 895
Query: 272 --QDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGS 329
L F L ++VTVF + T + W +L + + ++++YFI + G+
Sbjct: 896 DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVL---YNGMASTSSWAALYFIALMTFGN 952
Query: 330 IIFRSIIVAMMVTNFQ 345
+ +++VA++V FQ
Sbjct: 953 YVLFNLLVAILVEGFQ 968
Score = 49.3 bits (116), Expect = 9e-06
Identities = 32/123 (26%), Positives = 63/123 (51%), Gaps = 11/123 (8%)
Query: 152 FILLIFILEILLKWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVVLVGVTGQSVWL 206
FI F +E+++K ++ +F K WN DF + + +L + L Q+V
Sbjct: 123 FIFAFFAVEMVVKMVA-LGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDL-----QNVSF 176
Query: 207 QLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEY 266
+R RVLR L+ + + ++I++ +L+ L + +L+L F+IF + GV +++
Sbjct: 177 SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236
Query: 267 TRS 269
R+
Sbjct: 237 LRN 239
Score = 37.0 bits (84), Expect = 0.045
Identities = 17/82 (20%), Positives = 44/82 (53%), Gaps = 3/82 (3%)
Query: 280 FSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAM 339
F ++ + + +F + TL+ W ++ + V + ++ IYFIL +++GS ++ + +
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIM---YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVV 393
Query: 340 MVTNFQNIRKELNEEMARREVQ 361
+ T F ++ ++ M + V+
Sbjct: 394 IATQFSETKQRESQLMREQRVR 415
>gi|38505290 voltage-dependent calcium channel alpha 1G subunit
isoform 13 [Homo sapiens]
Length = 2243
Score = 96.7 bits (239), Expect = 5e-20
Identities = 66/313 (21%), Positives = 158/313 (50%), Gaps = 40/313 (12%)
Query: 109 LFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLK---- 164
+F + ++ ++FLN I + +E ++ + + ++ L ++ + +F+ E+ +K
Sbjct: 1254 MFDHVVLVIIFLNCITIAMERPKIDPHSAE----RIFLTLSNYIFTAVFLAEMTVKVVAL 1309
Query: 165 -WLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV--WLQLLRICRVLRSLKLL 221
W + +S+WNV D ++ ++S++ +V +V +G + L++LR+ R LR L+++
Sbjct: 1310 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1369
Query: 222 AQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------------------ 263
++ + +++++ L+ +LK + ++++ FF IF + GV +F
Sbjct: 1370 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNK 1429
Query: 264 SEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRI-------F 316
S+ + + + + F +L +L+++F+L + D W ++ D V + +
Sbjct: 1430 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1489
Query: 317 SSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADMFKRQIIQRRK 376
+YFI +LL+ + ++ V ++V NF R+ EE ARR + + R++ ++R+
Sbjct: 1490 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL----RRLEKKRR 1545
Query: 377 NMSHEALTSSHSK 389
+ S +S+
Sbjct: 1546 KAQCKPYYSDYSR 1558
Score = 92.8 bits (229), Expect = 7e-19
Identities = 58/234 (24%), Positives = 123/234 (52%), Gaps = 14/234 (5%)
Query: 146 LEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSL----LPEVVVLVGVT 200
L++ + +IF+LE + K ++ F F++ WN D + +LS+ L E+ V +
Sbjct: 1602 LKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLP 1661
Query: 201 GQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGV 260
++++R+ R+ R LKLL ++ ++ +++AL + L +L ++ F+IFA GV
Sbjct: 1662 INPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGV 1721
Query: 261 YVFSEY---TRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPE-----V 312
+F + P + L H F + + +T+F + T D+W +++D + +
Sbjct: 1722 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1781
Query: 313 SRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADM 366
+ + S IYF+ ++L + ++++A+++ + + KE EE A E +L+ +M
Sbjct: 1782 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE-AELEAELELEM 1834
Score = 86.3 bits (212), Expect = 6e-17
Identities = 72/256 (28%), Positives = 131/256 (51%), Gaps = 15/256 (5%)
Query: 96 PLSLWAGWVLECPLFKNFIIFLVFLNTIILMVEIELLE-STNTKLWPLKLT--LEVAAWF 152
P S+ A W L C F+ + F I++ + + L P +LT LE++
Sbjct: 722 PSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIV 781
Query: 153 ILLIFILEILLKWLSNFSV-FWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRI 211
+F LE+LLK L + K+ +N+FD V+ ++S V +VG G L +LR
Sbjct: 782 FTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVIS----VWEIVGQQGGG--LSVLRT 835
Query: 212 CRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPR 271
R++R LKL+ +Q ++VL++ + ++ MLL++F +IF++ G+++F S R
Sbjct: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASER 895
Query: 272 --QDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGS 329
L F L ++VTVF + T + W +L + + ++++YFI + G+
Sbjct: 896 DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVL---YNGMASTSSWAALYFIALMTFGN 952
Query: 330 IIFRSIIVAMMVTNFQ 345
+ +++VA++V FQ
Sbjct: 953 YVLFNLLVAILVEGFQ 968
Score = 49.3 bits (116), Expect = 9e-06
Identities = 32/123 (26%), Positives = 63/123 (51%), Gaps = 11/123 (8%)
Query: 152 FILLIFILEILLKWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVVLVGVTGQSVWL 206
FI F +E+++K ++ +F K WN DF + + +L + L Q+V
Sbjct: 123 FIFAFFAVEMVVKMVA-LGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDL-----QNVSF 176
Query: 207 QLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEY 266
+R RVLR L+ + + ++I++ +L+ L + +L+L F+IF + GV +++
Sbjct: 177 SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236
Query: 267 TRS 269
R+
Sbjct: 237 LRN 239
Score = 37.0 bits (84), Expect = 0.045
Identities = 17/82 (20%), Positives = 44/82 (53%), Gaps = 3/82 (3%)
Query: 280 FSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAM 339
F ++ + + +F + TL+ W ++ + V + ++ IYFIL +++GS ++ + +
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIM---YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVV 393
Query: 340 MVTNFQNIRKELNEEMARREVQ 361
+ T F ++ ++ M + V+
Sbjct: 394 IATQFSETKQRESQLMREQRVR 415
>gi|38505286 voltage-dependent calcium channel alpha 1G subunit
isoform 10 [Homo sapiens]
Length = 2266
Score = 96.7 bits (239), Expect = 5e-20
Identities = 66/313 (21%), Positives = 158/313 (50%), Gaps = 40/313 (12%)
Query: 109 LFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLK---- 164
+F + ++ ++FLN I + +E ++ + + ++ L ++ + +F+ E+ +K
Sbjct: 1277 MFDHVVLVIIFLNCITIAMERPKIDPHSAE----RIFLTLSNYIFTAVFLAEMTVKVVAL 1332
Query: 165 -WLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV--WLQLLRICRVLRSLKLL 221
W + +S+WNV D ++ ++S++ +V +V +G + L++LR+ R LR L+++
Sbjct: 1333 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1392
Query: 222 AQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------------------ 263
++ + +++++ L+ +LK + ++++ FF IF + GV +F
Sbjct: 1393 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNK 1452
Query: 264 SEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRI-------F 316
S+ + + + + F +L +L+++F+L + D W ++ D V + +
Sbjct: 1453 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1512
Query: 317 SSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADMFKRQIIQRRK 376
+YFI +LL+ + ++ V ++V NF R+ EE ARR + + R++ ++R+
Sbjct: 1513 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL----RRLEKKRR 1568
Query: 377 NMSHEALTSSHSK 389
+ S +S+
Sbjct: 1569 KAQCKPYYSDYSR 1581
Score = 92.8 bits (229), Expect = 7e-19
Identities = 58/234 (24%), Positives = 123/234 (52%), Gaps = 14/234 (5%)
Query: 146 LEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSL----LPEVVVLVGVT 200
L++ + +IF+LE + K ++ F F++ WN D + +LS+ L E+ V +
Sbjct: 1625 LKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLP 1684
Query: 201 GQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGV 260
++++R+ R+ R LKLL ++ ++ +++AL + L +L ++ F+IFA GV
Sbjct: 1685 INPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGV 1744
Query: 261 YVFSEY---TRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPE-----V 312
+F + P + L H F + + +T+F + T D+W +++D + +
Sbjct: 1745 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1804
Query: 313 SRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADM 366
+ + S IYF+ ++L + ++++A+++ + + KE EE A E +L+ +M
Sbjct: 1805 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE-AELEAELELEM 1857
Score = 88.2 bits (217), Expect = 2e-17
Identities = 76/270 (28%), Positives = 138/270 (51%), Gaps = 21/270 (7%)
Query: 96 PLSLWAGWVLECPLFKNFIIFLVFLNTIILMVEIELLE-STNTKLWPLKLT--LEVAAWF 152
P S+ A W L C F+ + F I++ + + L P +LT LE++
Sbjct: 722 PSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIV 781
Query: 153 ILLIFILEILLKWLSNFSV-FWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRI 211
+F LE+LLK L + K+ +N+FD V+ ++S V +VG G L +LR
Sbjct: 782 FTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVIS----VWEIVGQQGGG--LSVLRT 835
Query: 212 CRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPR 271
R++R LKL+ +Q ++VL++ + ++ MLL++F +IF++ G+++F S R
Sbjct: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASER 895
Query: 272 --QDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGS 329
L F L ++VTVF + T + W +L + + ++++YFI + G+
Sbjct: 896 DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVL---YNGMASTSSWAALYFIALMTFGN 952
Query: 330 IIFRSIIVAMMVTNFQNIRKELNEEMARRE 359
+ +++VA++V FQ EE+++RE
Sbjct: 953 YVLFNLLVAILVEGFQ------AEEISKRE 976
Score = 49.3 bits (116), Expect = 9e-06
Identities = 32/123 (26%), Positives = 63/123 (51%), Gaps = 11/123 (8%)
Query: 152 FILLIFILEILLKWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVVLVGVTGQSVWL 206
FI F +E+++K ++ +F K WN DF + + +L + L Q+V
Sbjct: 123 FIFAFFAVEMVVKMVA-LGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDL-----QNVSF 176
Query: 207 QLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEY 266
+R RVLR L+ + + ++I++ +L+ L + +L+L F+IF + GV +++
Sbjct: 177 SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236
Query: 267 TRS 269
R+
Sbjct: 237 LRN 239
Score = 37.0 bits (84), Expect = 0.045
Identities = 17/82 (20%), Positives = 44/82 (53%), Gaps = 3/82 (3%)
Query: 280 FSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAM 339
F ++ + + +F + TL+ W ++ + V + ++ IYFIL +++GS ++ + +
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIM---YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVV 393
Query: 340 MVTNFQNIRKELNEEMARREVQ 361
+ T F ++ ++ M + V+
Sbjct: 394 IATQFSETKQRESQLMREQRVR 415
>gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H
subunit isoform b [Homo sapiens]
Length = 2347
Score = 95.5 bits (236), Expect = 1e-19
Identities = 67/272 (24%), Positives = 136/272 (50%), Gaps = 27/272 (9%)
Query: 113 FIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWLS-NFSV 171
FI F++ +N I + +E + L L+ + ++F+ E LK ++ F
Sbjct: 1616 FITFIICVNVITMSMEHYNQPKS------LDEALKYCNYVFTIVFVFEAALKLVAFGFRR 1669
Query: 172 FWKSAWNVFDFVVTMLSL----LPEVVVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQI 227
F+K WN D + +LSL L E+ + + ++++R+ R+ R LKLL +
Sbjct: 1670 FFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGM 1729
Query: 228 QIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRS---PRQDLEYHVFFSDLP 284
+ ++ +V+AL + L +L ++ F+I+A GV +F S P + L H FS+
Sbjct: 1730 RALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFG 1789
Query: 285 NSLVTVFILFTLDHWYALLQDVWKVPEVSR----------IFSSIYFILWLLLGSIIFRS 334
+ +T+F + T D+W +++D + E SR S +YF+ ++L+ + +
Sbjct: 1790 MAFLTLFRVSTGDNWNGIMKDTLR--ECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVN 1847
Query: 335 IIVAMMVTNFQNIRKELNEEMARREVQLKADM 366
++VA+++ + + KE E+ A + +++ +M
Sbjct: 1848 VVVAVLMKHLEESNKEARED-AELDAEIELEM 1878
Score = 93.6 bits (231), Expect = 4e-19
Identities = 72/306 (23%), Positives = 153/306 (50%), Gaps = 38/306 (12%)
Query: 104 VLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILL 163
V+ +F + ++ +FLN + + +E ++ +T+ ++ L V+ + IF+ E+++
Sbjct: 1290 VITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTE----RVFLSVSNYIFTAIFVAEMMV 1345
Query: 164 K-----WLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVW--LQLLRICRVLR 216
K LS + +S+WN+ D ++ ++SL+ VV + G + L++LR+ R LR
Sbjct: 1346 KVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLR 1405
Query: 217 SLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEY---------- 266
L+++++ +++++ L+ +L+ + ++++ FF IF + GV +F
Sbjct: 1406 PLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTR 1465
Query: 267 ---TRSPRQDLEYHVF-----FSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRI--- 315
T++ + Y F +L +L+++F+L + D W ++ D V +
Sbjct: 1466 NISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQ 1525
Query: 316 ----FSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARR--EVQLKADMFKR 369
+ +YFI +LL+ S ++ V ++V NF R+ E ARR E +L+ +R
Sbjct: 1526 NHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLERRR 1585
Query: 370 QIIQRR 375
+ QRR
Sbjct: 1586 RKAQRR 1591
Score = 76.6 bits (187), Expect = 5e-14
Identities = 67/301 (22%), Positives = 145/301 (48%), Gaps = 27/301 (8%)
Query: 104 VLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILL 163
+++ F I+ + +NT+ + VE T LE++ +F LE+LL
Sbjct: 789 IVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTN------ALEISNIVFTSMFALEMLL 842
Query: 164 KWLSNFSV-FWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVW-LQLLRICRVLRSLKLL 221
K L+ + + ++ +N+FD ++ ++S+ + GQ+ L +LR R+LR LKL+
Sbjct: 843 KLLACGPLGYIRNPYNIFDGIIVVISVWE-------IVGQADGGLSVLRTFRLLRVLKLV 895
Query: 222 AQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFS---EYTRSPRQDLEYHV 278
++ ++VLV+ + ++ LL++F +IF++ G+++F +
Sbjct: 896 RFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRK 955
Query: 279 FFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVA 338
F L ++VTVF + T + W +L + + ++++YF+ + G+ + +++VA
Sbjct: 956 NFDSLLWAIVTVFQILTQEDWNVVL---YNGMASTSSWAALYFVALMTFGNYVLFNLLVA 1012
Query: 339 MMVTNFQ----NIRKELNEEMARREVQLKADMFKRQIIQRRKNMSHEALTSSHSKIEDRG 394
++V FQ R + +E+ + V + D K + +Q + + + +E RG
Sbjct: 1013 ILVEGFQAEGDANRSDTDED--KTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLEGRG 1070
Query: 395 A 395
+
Sbjct: 1071 S 1071
Score = 50.8 bits (120), Expect = 3e-06
Identities = 31/128 (24%), Positives = 63/128 (49%), Gaps = 9/128 (7%)
Query: 146 LEVAAWFILLIFILEILLKWLS----NFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTG 201
LE FI F +E+++K ++ + WN DF + + ++ + G
Sbjct: 136 LEAFDAFIFAFFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMME-----YSLDG 190
Query: 202 QSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVY 261
+V L +R RVLR L+ + + ++I++ +L+ L + +L+L F+IF + GV
Sbjct: 191 HNVSLSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQ 250
Query: 262 VFSEYTRS 269
+++ R+
Sbjct: 251 LWAGLLRN 258
Score = 38.9 bits (89), Expect = 0.012
Identities = 25/110 (22%), Positives = 56/110 (50%), Gaps = 18/110 (16%)
Query: 280 FSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAM 339
F ++ + + +F + TL+ W ++ + V + ++ IYFIL +++GS ++ + +
Sbjct: 361 FDNIGYAWIAIFQVITLEGWVDIM---YYVMDAHSFYNFIYFILLIIVGSFFMINLCLVV 417
Query: 340 MVTNFQNIRKELNEEMARREVQLKADMFKRQIIQRRKNMSHEALTSSHSK 389
+ T F E +RE QL + QR +++S+++ +S S+
Sbjct: 418 IATQF--------SETKQRESQLMRE-------QRARHLSNDSTLASFSE 452
>gi|53832009 calcium channel, voltage-dependent, T type, alpha 1H
subunit isoform a [Homo sapiens]
Length = 2353
Score = 95.5 bits (236), Expect = 1e-19
Identities = 67/272 (24%), Positives = 136/272 (50%), Gaps = 27/272 (9%)
Query: 113 FIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWLS-NFSV 171
FI F++ +N I + +E + L L+ + ++F+ E LK ++ F
Sbjct: 1622 FITFIICVNVITMSMEHYNQPKS------LDEALKYCNYVFTIVFVFEAALKLVAFGFRR 1675
Query: 172 FWKSAWNVFDFVVTMLSL----LPEVVVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQI 227
F+K WN D + +LSL L E+ + + ++++R+ R+ R LKLL +
Sbjct: 1676 FFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGM 1735
Query: 228 QIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRS---PRQDLEYHVFFSDLP 284
+ ++ +V+AL + L +L ++ F+I+A GV +F S P + L H FS+
Sbjct: 1736 RALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFG 1795
Query: 285 NSLVTVFILFTLDHWYALLQDVWKVPEVSR----------IFSSIYFILWLLLGSIIFRS 334
+ +T+F + T D+W +++D + E SR S +YF+ ++L+ + +
Sbjct: 1796 MAFLTLFRVSTGDNWNGIMKDTLR--ECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVN 1853
Query: 335 IIVAMMVTNFQNIRKELNEEMARREVQLKADM 366
++VA+++ + + KE E+ A + +++ +M
Sbjct: 1854 VVVAVLMKHLEESNKEARED-AELDAEIELEM 1884
Score = 92.4 bits (228), Expect = 9e-19
Identities = 67/299 (22%), Positives = 148/299 (49%), Gaps = 36/299 (12%)
Query: 104 VLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILL 163
V+ +F + ++ +FLN + + +E ++ +T+ ++ L V+ + IF+ E+++
Sbjct: 1290 VITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTE----RVFLSVSNYIFTAIFVAEMMV 1345
Query: 164 K-----WLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVW--LQLLRICRVLR 216
K LS + +S+WN+ D ++ ++SL+ VV + G + L++LR+ R LR
Sbjct: 1346 KVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLR 1405
Query: 217 SLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEY---------- 266
L+++++ +++++ L+ +L+ + ++++ FF IF + GV +F
Sbjct: 1406 PLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTR 1465
Query: 267 ---TRSPRQDLEYHVF-----FSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRI--- 315
T++ + Y F +L +L+++F+L + D W ++ D V +
Sbjct: 1466 NISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQ 1525
Query: 316 ----FSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADMFKRQ 370
+ +YFI +LL+ S ++ V ++V NF R+ E ARR + + +R+
Sbjct: 1526 NHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLERR 1584
Score = 76.6 bits (187), Expect = 5e-14
Identities = 67/301 (22%), Positives = 145/301 (48%), Gaps = 27/301 (8%)
Query: 104 VLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILL 163
+++ F I+ + +NT+ + VE T LE++ +F LE+LL
Sbjct: 789 IVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTN------ALEISNIVFTSMFALEMLL 842
Query: 164 KWLSNFSV-FWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVW-LQLLRICRVLRSLKLL 221
K L+ + + ++ +N+FD ++ ++S+ + GQ+ L +LR R+LR LKL+
Sbjct: 843 KLLACGPLGYIRNPYNIFDGIIVVISVWE-------IVGQADGGLSVLRTFRLLRVLKLV 895
Query: 222 AQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFS---EYTRSPRQDLEYHV 278
++ ++VLV+ + ++ LL++F +IF++ G+++F +
Sbjct: 896 RFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRK 955
Query: 279 FFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVA 338
F L ++VTVF + T + W +L + + ++++YF+ + G+ + +++VA
Sbjct: 956 NFDSLLWAIVTVFQILTQEDWNVVL---YNGMASTSSWAALYFVALMTFGNYVLFNLLVA 1012
Query: 339 MMVTNFQ----NIRKELNEEMARREVQLKADMFKRQIIQRRKNMSHEALTSSHSKIEDRG 394
++V FQ R + +E+ + V + D K + +Q + + + +E RG
Sbjct: 1013 ILVEGFQAEGDANRSDTDED--KTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLEGRG 1070
Query: 395 A 395
+
Sbjct: 1071 S 1071
Score = 50.8 bits (120), Expect = 3e-06
Identities = 31/128 (24%), Positives = 63/128 (49%), Gaps = 9/128 (7%)
Query: 146 LEVAAWFILLIFILEILLKWLS----NFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTG 201
LE FI F +E+++K ++ + WN DF + + ++ + G
Sbjct: 136 LEAFDAFIFAFFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMME-----YSLDG 190
Query: 202 QSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVY 261
+V L +R RVLR L+ + + ++I++ +L+ L + +L+L F+IF + GV
Sbjct: 191 HNVSLSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQ 250
Query: 262 VFSEYTRS 269
+++ R+
Sbjct: 251 LWAGLLRN 258
Score = 38.9 bits (89), Expect = 0.012
Identities = 25/110 (22%), Positives = 56/110 (50%), Gaps = 18/110 (16%)
Query: 280 FSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAM 339
F ++ + + +F + TL+ W ++ + V + ++ IYFIL +++GS ++ + +
Sbjct: 361 FDNIGYAWIAIFQVITLEGWVDIM---YYVMDAHSFYNFIYFILLIIVGSFFMINLCLVV 417
Query: 340 MVTNFQNIRKELNEEMARREVQLKADMFKRQIIQRRKNMSHEALTSSHSK 389
+ T F E +RE QL + QR +++S+++ +S S+
Sbjct: 418 IATQF--------SETKQRESQLMRE-------QRARHLSNDSTLASFSE 452
>gi|53832005 calcium channel, voltage-dependent, R type, alpha 1E
subunit [Homo sapiens]
Length = 2270
Score = 95.1 bits (235), Expect = 1e-19
Identities = 89/336 (26%), Positives = 163/336 (48%), Gaps = 33/336 (9%)
Query: 64 LVRFSIKPQRIEQIS---HAQRLLSRLHVRCSQRPPLSLWAGWVLECPLFKNFIIFLVFL 120
L R SIK +++ +S H +RLL R+ +R + + W ++ LV L
Sbjct: 442 LARASIKSAKVDGVSYFRHKERLL-RISIRHMVKSQVFYW------------IVLSLVAL 488
Query: 121 NTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNV 179
NT + + N W L L A + L +F+LE+ LK +++ S++N
Sbjct: 489 NTACVAIVHH-----NQPQWLTHL-LYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFNC 542
Query: 180 FDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALK 239
FDF VT+ S+ EVV + G S + +LR R+LR K+ + ++ +++ L+ ++K
Sbjct: 543 FDFGVTVGSIF-EVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSMK 601
Query: 240 SMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHW 299
S+ LL LL +F +FA+ G+ +F R D F P +++TVF + T + W
Sbjct: 602 SIISLLFLLFLFIVVFALLGMQLFG--GRFNFNDGTPSANFDTFPAAIMTVFQILTGEDW 659
Query: 300 YALLQDVWKVP--EVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMAR 357
++ + + S ++S+IYFI+ L G+ ++ +A+ V N N +E+ +
Sbjct: 660 NEVMYNGIRSQGGVSSGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANA-----QELTK 714
Query: 358 REVQLKADMFKRQIIQRRKNMSHEALTSSHSKIEDR 393
E + + ++ +Q+ K +S + + S DR
Sbjct: 715 DEQEEEEAFNQKHALQKAKEVSPMSAPNMPSIERDR 750
Score = 85.9 bits (211), Expect = 8e-17
Identities = 61/264 (23%), Positives = 132/264 (50%), Gaps = 30/264 (11%)
Query: 108 PLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWLS 167
P F+ I+ ++ LNT++LM++ T +L L+ ++F LE +LK ++
Sbjct: 1478 PSFEYTIMAMIALNTVVLMMKYYSAPCT------YELALKYLNIAFTMVFSLECVLKVIA 1531
Query: 168 -NFSVFWKSAWNVFDFVVTMLSLLPEVVV----LVGVTGQSVWLQLLRICRVLRSLKLLA 222
F +++ WN+FDF+ T++ + E+++ LV +G + + L++ R R +KLL
Sbjct: 1532 FGFLNYFRDTWNIFDFI-TVIGSITEIILTDSKLVNTSGFN--MSFLKLFRAARLIKLLR 1588
Query: 223 QFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHVFFSD 282
Q I+I++ V++ K++ ++ +L+ + F+I+A+ G+ VF + H F
Sbjct: 1589 QGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLDEESHINRHNNFRS 1648
Query: 283 LPNSLVTVFILFTLDHWYAL----LQDVWKVPEVSRI------------FSSIYFILWLL 326
SL+ +F T + W + L + P+ + + +YF+ ++
Sbjct: 1649 FFGSLMLLFRSATGEAWQEIMLSCLGEKGCEPDTTAPSGQNENERCGTDLAYVYFVSFIF 1708
Query: 327 LGSIIFRSIIVAMMVTNFQNIRKE 350
S + ++ VA+++ NF+ + ++
Sbjct: 1709 FCSFLMLNLFVAVIMDNFEYLTRD 1732
Score = 67.4 bits (163), Expect = 3e-11
Identities = 66/311 (21%), Positives = 133/311 (42%), Gaps = 55/311 (17%)
Query: 100 WAGWVLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFIL 159
+A +++ P F+ I+ + N I+L +E L E T P+ LE + + IF
Sbjct: 81 YAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKT---PMSRRLEKTEPYFIGIFCF 137
Query: 160 EILLKWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRICRV 214
E +K ++ +F K + WNV DF+V + +L V L+ LR RV
Sbjct: 138 EAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNT---HVDLRTLRAVRV 194
Query: 215 LRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTR------ 268
LR LKL++ +QI++ +++A+ + + +LL +FA+ G+ +S
Sbjct: 195 LRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMN 254
Query: 269 -----------------------------SPRQDLEYHVFFSDLPNSLVTVFILFTLDHW 299
P + F ++ +++TVF T++ W
Sbjct: 255 NSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQ---FDNILFAVLTVFQCITMEGW 311
Query: 300 YALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMA--- 356
+L + + ++ +YFI +++GS ++++ ++ F R+ + A
Sbjct: 312 TTVLYNT--NDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERERVENRRAFMK 369
Query: 357 -RREVQLKADM 366
RR+ Q++ ++
Sbjct: 370 LRRQQQIEREL 380
Score = 65.9 bits (159), Expect = 9e-11
Identities = 61/301 (20%), Positives = 135/301 (44%), Gaps = 47/301 (15%)
Query: 96 PLSLWAGWVLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILL 155
P+ +++ F+ I+ ++ ++I L E +L ++ L +
Sbjct: 1141 PIRRACHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNK-----VLRYFDYVFTG 1195
Query: 156 IFILEILLKWLSNFSV-----FWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQS---VWLQ 207
+F E+++K + + +++ WN+ DFVV + +L+ + T + ++
Sbjct: 1196 VFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIK 1255
Query: 208 LLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSE-- 265
LR+ RVLR LK + + +++ + +V +LK++ +L++ +F +IFAV V +F
Sbjct: 1256 SLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKF 1315
Query: 266 -YTRSPRQDLE------------------------YHVFFSDLPNSLVTVFILFTLDHWY 300
Y +D E + + ++ +L+T+F + T + W
Sbjct: 1316 FYCTDSSKDTEKECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWP 1375
Query: 301 ALLQDVWKVPE-------VSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNE 353
+LQ V E +R+ SI+++++ ++ F +I VA+++ FQ ++ E
Sbjct: 1376 QVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMME 1435
Query: 354 E 354
E
Sbjct: 1436 E 1436
>gi|193788732 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 5 [Homo sapiens]
Length = 2166
Score = 94.0 bits (232), Expect = 3e-19
Identities = 86/344 (25%), Positives = 154/344 (44%), Gaps = 32/344 (9%)
Query: 85 SRLHVRCSQRPPLSLWAGWVLECP----------LFKNFIIFLVFLNTIILMVEIELLES 134
+RL R S+ W W C +F +IFLVFLNT+ + E
Sbjct: 491 ARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASE-----H 545
Query: 135 TNTKLWPLKLTLEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSLLPEV 193
N W L + A +L +F E+LLK S ++ S +N FD V +L +
Sbjct: 546 YNQPNW-LTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETI 604
Query: 194 VVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFY 253
+V + + + +LR R+LR K+ + + ++ L+ +++S+ LL+LL +F
Sbjct: 605 LVETKIMSP-LGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFII 663
Query: 254 IFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQD---VWKVP 310
IF++ G+ +F F + P SL+TVF + T + W +++ D + P
Sbjct: 664 IFSLLGMQLFGGKFNFDEMQTRRSTF-DNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGP 722
Query: 311 EVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTN------FQNIRKELNEEMARREVQLKA 364
+ IYFI+ + G+ I ++ +A+ V N + +KE EE R+++ A
Sbjct: 723 SFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTA 782
Query: 365 DMFKRQIIQRRKNMSHEALTSSHSKIEDRGASQQRESLDLSEVS 408
K+Q + + + S KIE + + ES ++++
Sbjct: 783 SPEKKQELVEKPAVGE----SKEEKIELKSITADGESPPATKIN 822
Score = 71.6 bits (174), Expect = 2e-12
Identities = 60/300 (20%), Positives = 136/300 (45%), Gaps = 52/300 (17%)
Query: 103 WVLECPLFKNFIIFLVFLNTIILMVE-----------IELLESTNTKLWPLKLTLEVAAW 151
+V+ F+ + L+ LNTI L ++ + +L T L+ +++ L++ A+
Sbjct: 1214 YVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAF 1273
Query: 152 ------------FILLIFILEILLKWLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGV 199
F LI I I+ LS + ++ AWN FD ++ + S++ + V
Sbjct: 1274 KPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNP 1333
Query: 200 TGQS-------------VWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLM 246
+ + + R+ RV+R +KLL++ I+ ++ +++ +++ ++ +
Sbjct: 1334 AEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVAL 1393
Query: 247 LLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHW----YAL 302
L+++ F+I+AV G+ VF + + ++ + F P +++ +F T + W A
Sbjct: 1394 LIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLAC 1453
Query: 303 LQDVWKVPE------------VSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKE 350
+ PE F+ YFI + +L + + ++ VA+++ NF + ++
Sbjct: 1454 MPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRD 1513
Score = 70.9 bits (172), Expect = 3e-12
Identities = 69/320 (21%), Positives = 138/320 (43%), Gaps = 62/320 (19%)
Query: 104 VLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILL 163
++E F+ I+ +F N + L + I E + LE + L+IF +E L
Sbjct: 120 IVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNAT---NSNLERVEYLFLIIFTVEAFL 176
Query: 164 KWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVV---------LVGVTGQSVWLQLL 209
K ++ +F +A WN+ DF++ ++ L ++ +G G ++ L
Sbjct: 177 KVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKAL 236
Query: 210 RICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------ 263
R RVLR L+L++ +Q+++ +++A+ + + +L+L I+A+ G+ +F
Sbjct: 237 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296
Query: 264 ------------SEYTRSP--------RQ-----------DLEYH--VFFSDLPNSLVTV 290
+E SP RQ D H F + +++TV
Sbjct: 297 TCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTV 356
Query: 291 FILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKE 350
F T++ W +L W V R + IYF+ +++GS ++++ ++ F R++
Sbjct: 357 FQCITMEGWTDVL--YWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREK 414
Query: 351 LNE----EMARREVQLKADM 366
+ R + QL+ D+
Sbjct: 415 AKARGDFQKLREKQQLEEDL 434
Score = 51.2 bits (121), Expect = 2e-06
Identities = 57/283 (20%), Positives = 125/283 (44%), Gaps = 59/283 (20%)
Query: 109 LFKNFIIFLVFLNTIILMVE--IELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWL 166
+F N I+F + L++I L E ++ N L+ + IF +EI LK
Sbjct: 901 IFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTT-------IFTIEIALKMT 953
Query: 167 S-----NFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV-WLQLLRICRVLRSLKL 220
+ + F ++ +N+ D +V +SL+ G+ ++ +++LR+ RVLR L+
Sbjct: 954 AYGAFLHKGSFCRNYFNILDLLVVSVSLIS-----FGIQSSAINVVKILRVLRVLRPLRA 1008
Query: 221 LAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSE--YTRS--------- 269
+ + + ++ ++ + A++++ ++++ + ++FA GV +F YT S
Sbjct: 1009 INRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAE 1068
Query: 270 -------------------PRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALL------- 303
PR F ++ +++ +F + T + W LL
Sbjct: 1069 CKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSH 1128
Query: 304 -QDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQ 345
+D + R+ SI+FI+++++ + +I V ++ FQ
Sbjct: 1129 TEDKGPIYNY-RVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQ 1170
>gi|193788730 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 4 [Homo sapiens]
Length = 2173
Score = 94.0 bits (232), Expect = 3e-19
Identities = 86/344 (25%), Positives = 154/344 (44%), Gaps = 32/344 (9%)
Query: 85 SRLHVRCSQRPPLSLWAGWVLECP----------LFKNFIIFLVFLNTIILMVEIELLES 134
+RL R S+ W W C +F +IFLVFLNT+ + E
Sbjct: 491 ARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASE-----H 545
Query: 135 TNTKLWPLKLTLEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSLLPEV 193
N W L + A +L +F E+LLK S ++ S +N FD V +L +
Sbjct: 546 YNQPNW-LTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETI 604
Query: 194 VVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFY 253
+V + + + +LR R+LR K+ + + ++ L+ +++S+ LL+LL +F
Sbjct: 605 LVETKIMSP-LGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFII 663
Query: 254 IFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQD---VWKVP 310
IF++ G+ +F F + P SL+TVF + T + W +++ D + P
Sbjct: 664 IFSLLGMQLFGGKFNFDEMQTRRSTF-DNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGP 722
Query: 311 EVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTN------FQNIRKELNEEMARREVQLKA 364
+ IYFI+ + G+ I ++ +A+ V N + +KE EE R+++ A
Sbjct: 723 SFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTA 782
Query: 365 DMFKRQIIQRRKNMSHEALTSSHSKIEDRGASQQRESLDLSEVS 408
K+Q + + + S KIE + + ES ++++
Sbjct: 783 SPEKKQELVEKPAVGE----SKEEKIELKSITADGESPPATKIN 822
Score = 70.9 bits (172), Expect = 3e-12
Identities = 69/320 (21%), Positives = 138/320 (43%), Gaps = 62/320 (19%)
Query: 104 VLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILL 163
++E F+ I+ +F N + L + I E + LE + L+IF +E L
Sbjct: 120 IVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNAT---NSNLERVEYLFLIIFTVEAFL 176
Query: 164 KWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVV---------LVGVTGQSVWLQLL 209
K ++ +F +A WN+ DF++ ++ L ++ +G G ++ L
Sbjct: 177 KVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKAL 236
Query: 210 RICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------ 263
R RVLR L+L++ +Q+++ +++A+ + + +L+L I+A+ G+ +F
Sbjct: 237 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296
Query: 264 ------------SEYTRSP--------RQ-----------DLEYH--VFFSDLPNSLVTV 290
+E SP RQ D H F + +++TV
Sbjct: 297 TCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTV 356
Query: 291 FILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKE 350
F T++ W +L W V R + IYF+ +++GS ++++ ++ F R++
Sbjct: 357 FQCITMEGWTDVL--YWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREK 414
Query: 351 LNE----EMARREVQLKADM 366
+ R + QL+ D+
Sbjct: 415 AKARGDFQKLREKQQLEEDL 434
Score = 68.9 bits (167), Expect = 1e-11
Identities = 53/278 (19%), Positives = 128/278 (46%), Gaps = 36/278 (12%)
Query: 103 WVLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEIL 162
+V+ F+ + L+ LNTI L ++ + K+ + + +F +E++
Sbjct: 1214 YVVNSTYFEYLMFVLILLNTICLAMQ------HYGQSCLFKIAMNILNMLFTGLFTVEMI 1267
Query: 163 LKWLS-NFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQS-------------VWLQL 208
LK ++ ++ AWN FD ++ + S++ + V + + +
Sbjct: 1268 LKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITF 1327
Query: 209 LRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTR 268
R+ RV+R +KLL++ I+ ++ +++ +++ ++ +L+++ F+I+AV G+ VF +
Sbjct: 1328 FRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIAL 1387
Query: 269 SPRQDLEYHVFFSDLPNSLVTVFILFTLDHW----YALLQDVWKVPE------------V 312
+ ++ + F P +++ +F T + W A + PE
Sbjct: 1388 NDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPC 1447
Query: 313 SRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKE 350
F+ YFI + +L + + ++ VA+++ NF + ++
Sbjct: 1448 GSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRD 1485
Score = 55.1 bits (131), Expect = 2e-07
Identities = 59/281 (20%), Positives = 129/281 (45%), Gaps = 55/281 (19%)
Query: 109 LFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWLS- 167
+F N I+F + L++I L E + ++ T+ + L A + IF LEI+LK +
Sbjct: 901 IFTNLILFFILLSSISLAAE-DPVQHTSFR----NHILGNADYVFTSIFTLEIILKMTAY 955
Query: 168 ----NFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV-WLQLLRICRVLRSLKLLA 222
+ F ++ +N+ D +V +SL+ G+ ++ +++LR+ RVLR L+ +
Sbjct: 956 GAFLHKGSFCRNYFNILDLLVVSVSLIS-----FGIQSSAINVVKILRVLRVLRPLRAIN 1010
Query: 223 QFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSE--YTRS----------- 269
+ + ++ ++ + A++++ ++++ + ++FA GV +F YT S
Sbjct: 1011 RAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECK 1070
Query: 270 -----------------PRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALL--------Q 304
PR F ++ +++ +F + T + W LL +
Sbjct: 1071 GNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTE 1130
Query: 305 DVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQ 345
D + R+ SI+FI+++++ + +I V ++ FQ
Sbjct: 1131 DKGPIYNY-RVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQ 1170
>gi|193788728 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 3 [Homo sapiens]
Length = 2179
Score = 94.0 bits (232), Expect = 3e-19
Identities = 86/344 (25%), Positives = 154/344 (44%), Gaps = 32/344 (9%)
Query: 85 SRLHVRCSQRPPLSLWAGWVLECP----------LFKNFIIFLVFLNTIILMVEIELLES 134
+RL R S+ W W C +F +IFLVFLNT+ + E
Sbjct: 491 ARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASE-----H 545
Query: 135 TNTKLWPLKLTLEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSLLPEV 193
N W L + A +L +F E+LLK S ++ S +N FD V +L +
Sbjct: 546 YNQPNW-LTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETI 604
Query: 194 VVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFY 253
+V + + + +LR R+LR K+ + + ++ L+ +++S+ LL+LL +F
Sbjct: 605 LVETKIMSP-LGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFII 663
Query: 254 IFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQD---VWKVP 310
IF++ G+ +F F + P SL+TVF + T + W +++ D + P
Sbjct: 664 IFSLLGMQLFGGKFNFDEMQTRRSTF-DNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGP 722
Query: 311 EVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTN------FQNIRKELNEEMARREVQLKA 364
+ IYFI+ + G+ I ++ +A+ V N + +KE EE R+++ A
Sbjct: 723 SFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTA 782
Query: 365 DMFKRQIIQRRKNMSHEALTSSHSKIEDRGASQQRESLDLSEVS 408
K+Q + + + S KIE + + ES ++++
Sbjct: 783 SPEKKQELVEKPAVGE----SKEEKIELKSITADGESPPATKIN 822
Score = 70.9 bits (172), Expect = 3e-12
Identities = 69/320 (21%), Positives = 138/320 (43%), Gaps = 62/320 (19%)
Query: 104 VLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILL 163
++E F+ I+ +F N + L + I E + LE + L+IF +E L
Sbjct: 120 IVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNAT---NSNLERVEYLFLIIFTVEAFL 176
Query: 164 KWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVV---------LVGVTGQSVWLQLL 209
K ++ +F +A WN+ DF++ ++ L ++ +G G ++ L
Sbjct: 177 KVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKAL 236
Query: 210 RICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------ 263
R RVLR L+L++ +Q+++ +++A+ + + +L+L I+A+ G+ +F
Sbjct: 237 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296
Query: 264 ------------SEYTRSP--------RQ-----------DLEYH--VFFSDLPNSLVTV 290
+E SP RQ D H F + +++TV
Sbjct: 297 TCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTV 356
Query: 291 FILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKE 350
F T++ W +L W V R + IYF+ +++GS ++++ ++ F R++
Sbjct: 357 FQCITMEGWTDVL--YWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREK 414
Query: 351 LNE----EMARREVQLKADM 366
+ R + QL+ D+
Sbjct: 415 AKARGDFQKLREKQQLEEDL 434
Score = 61.6 bits (148), Expect = 2e-09
Identities = 55/300 (18%), Positives = 129/300 (43%), Gaps = 58/300 (19%)
Query: 103 WVLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEIL 162
+V+ F+ + L+ LNTI L ++ + K+ + + +F +E++
Sbjct: 1214 YVVNSTYFEYLMFVLILLNTICLAMQ------HYGQSCLFKIAMNILNMLFTGLFTVEMI 1267
Query: 163 LKWLS-NFSVFWKSAWNVFDFVVTMLSLL-------------------------PEVVVL 196
LK ++ ++ AWN FD ++ + S++ P + VL
Sbjct: 1268 LKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMGPSCSHPPLAVL 1327
Query: 197 VGVT----------GQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLM 246
+ + R+ RV+R +KLL++ I+ ++ +++ +++ ++ +
Sbjct: 1328 TAPPVADGFQNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVAL 1387
Query: 247 LLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHW----YAL 302
L+++ F+I+AV G+ VF + + ++ + F P +++ +F T + W A
Sbjct: 1388 LIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLAC 1447
Query: 303 LQDVWKVPE------------VSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKE 350
+ PE F+ YFI + +L + + ++ VA+++ NF + ++
Sbjct: 1448 MPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRD 1507
Score = 51.2 bits (121), Expect = 2e-06
Identities = 57/283 (20%), Positives = 125/283 (44%), Gaps = 59/283 (20%)
Query: 109 LFKNFIIFLVFLNTIILMVE--IELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWL 166
+F N I+F + L++I L E ++ N L+ + IF +EI LK
Sbjct: 901 IFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTT-------IFTIEIALKMT 953
Query: 167 S-----NFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV-WLQLLRICRVLRSLKL 220
+ + F ++ +N+ D +V +SL+ G+ ++ +++LR+ RVLR L+
Sbjct: 954 AYGAFLHKGSFCRNYFNILDLLVVSVSLIS-----FGIQSSAINVVKILRVLRVLRPLRA 1008
Query: 221 LAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSE--YTRS--------- 269
+ + + ++ ++ + A++++ ++++ + ++FA GV +F YT S
Sbjct: 1009 INRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAE 1068
Query: 270 -------------------PRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALL------- 303
PR F ++ +++ +F + T + W LL
Sbjct: 1069 CKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSH 1128
Query: 304 -QDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQ 345
+D + R+ SI+FI+++++ + +I V ++ FQ
Sbjct: 1129 TEDKGPIYNY-RVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQ 1170
>gi|193788724 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 2 [Homo sapiens]
Length = 2186
Score = 94.0 bits (232), Expect = 3e-19
Identities = 86/344 (25%), Positives = 154/344 (44%), Gaps = 32/344 (9%)
Query: 85 SRLHVRCSQRPPLSLWAGWVLECP----------LFKNFIIFLVFLNTIILMVEIELLES 134
+RL R S+ W W C +F +IFLVFLNT+ + E
Sbjct: 491 ARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASE-----H 545
Query: 135 TNTKLWPLKLTLEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSLLPEV 193
N W L + A +L +F E+LLK S ++ S +N FD V +L +
Sbjct: 546 YNQPNW-LTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETI 604
Query: 194 VVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFY 253
+V + + + +LR R+LR K+ + + ++ L+ +++S+ LL+LL +F
Sbjct: 605 LVETKIMSP-LGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFII 663
Query: 254 IFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQD---VWKVP 310
IF++ G+ +F F + P SL+TVF + T + W +++ D + P
Sbjct: 664 IFSLLGMQLFGGKFNFDEMQTRRSTF-DNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGP 722
Query: 311 EVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTN------FQNIRKELNEEMARREVQLKA 364
+ IYFI+ + G+ I ++ +A+ V N + +KE EE R+++ A
Sbjct: 723 SFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTA 782
Query: 365 DMFKRQIIQRRKNMSHEALTSSHSKIEDRGASQQRESLDLSEVS 408
K+Q + + + S KIE + + ES ++++
Sbjct: 783 SPEKKQELVEKPAVGE----SKEEKIELKSITADGESPPATKIN 822
Score = 71.6 bits (174), Expect = 2e-12
Identities = 60/300 (20%), Positives = 136/300 (45%), Gaps = 52/300 (17%)
Query: 103 WVLECPLFKNFIIFLVFLNTIILMVE-----------IELLESTNTKLWPLKLTLEVAAW 151
+V+ F+ + L+ LNTI L ++ + +L T L+ +++ L++ A+
Sbjct: 1234 YVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAF 1293
Query: 152 ------------FILLIFILEILLKWLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGV 199
F LI I I+ LS + ++ AWN FD ++ + S++ + V
Sbjct: 1294 KPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNP 1353
Query: 200 TGQS-------------VWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLM 246
+ + + R+ RV+R +KLL++ I+ ++ +++ +++ ++ +
Sbjct: 1354 AEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVAL 1413
Query: 247 LLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHW----YAL 302
L+++ F+I+AV G+ VF + + ++ + F P +++ +F T + W A
Sbjct: 1414 LIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLAC 1473
Query: 303 LQDVWKVPE------------VSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKE 350
+ PE F+ YFI + +L + + ++ VA+++ NF + ++
Sbjct: 1474 MPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRD 1533
Score = 70.9 bits (172), Expect = 3e-12
Identities = 69/320 (21%), Positives = 138/320 (43%), Gaps = 62/320 (19%)
Query: 104 VLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILL 163
++E F+ I+ +F N + L + I E + LE + L+IF +E L
Sbjct: 120 IVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNAT---NSNLERVEYLFLIIFTVEAFL 176
Query: 164 KWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVV---------LVGVTGQSVWLQLL 209
K ++ +F +A WN+ DF++ ++ L ++ +G G ++ L
Sbjct: 177 KVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKAL 236
Query: 210 RICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------ 263
R RVLR L+L++ +Q+++ +++A+ + + +L+L I+A+ G+ +F
Sbjct: 237 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296
Query: 264 ------------SEYTRSP--------RQ-----------DLEYH--VFFSDLPNSLVTV 290
+E SP RQ D H F + +++TV
Sbjct: 297 TCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTV 356
Query: 291 FILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKE 350
F T++ W +L W V R + IYF+ +++GS ++++ ++ F R++
Sbjct: 357 FQCITMEGWTDVL--YWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREK 414
Query: 351 LNE----EMARREVQLKADM 366
+ R + QL+ D+
Sbjct: 415 AKARGDFQKLREKQQLEEDL 434
Score = 55.8 bits (133), Expect = 9e-08
Identities = 59/296 (19%), Positives = 133/296 (44%), Gaps = 65/296 (21%)
Query: 109 LFKNFIIFLVFLNTIILMVE------------IELLESTNTKLWPLKLTLEV---AAWFI 153
+F N I+F + L++I L E + + T ++ +++ L++ A +
Sbjct: 901 IFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKILGNADYVF 960
Query: 154 LLIFILEILLKWLS-----NFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV-WLQ 207
IF LEI+LK + + F ++ +N+ D +V +SL+ G+ ++ ++
Sbjct: 961 TSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLIS-----FGIQSSAINVVK 1015
Query: 208 LLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSE-- 265
+LR+ RVLR L+ + + + ++ ++ + A++++ ++++ + ++FA GV +F
Sbjct: 1016 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1075
Query: 266 YTRS----------------------------PRQDLEYHVFFSDLPNSLVTVFILFTLD 297
YT S PR F ++ +++ +F + T +
Sbjct: 1076 YTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFE 1135
Query: 298 HWYALL--------QDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQ 345
W LL +D + R+ SI+FI+++++ + +I V ++ FQ
Sbjct: 1136 GWPELLYRSIDSHTEDKGPIYNY-RVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQ 1190
>gi|193788720 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 1 [Homo sapiens]
Length = 2221
Score = 94.0 bits (232), Expect = 3e-19
Identities = 86/344 (25%), Positives = 154/344 (44%), Gaps = 32/344 (9%)
Query: 85 SRLHVRCSQRPPLSLWAGWVLECP----------LFKNFIIFLVFLNTIILMVEIELLES 134
+RL R S+ W W C +F +IFLVFLNT+ + E
Sbjct: 491 ARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASE-----H 545
Query: 135 TNTKLWPLKLTLEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSLLPEV 193
N W L + A +L +F E+LLK S ++ S +N FD V +L +
Sbjct: 546 YNQPNW-LTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETI 604
Query: 194 VVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFY 253
+V + + + +LR R+LR K+ + + ++ L+ +++S+ LL+LL +F
Sbjct: 605 LVETKIMSP-LGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFII 663
Query: 254 IFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQD---VWKVP 310
IF++ G+ +F F + P SL+TVF + T + W +++ D + P
Sbjct: 664 IFSLLGMQLFGGKFNFDEMQTRRSTF-DNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGP 722
Query: 311 EVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTN------FQNIRKELNEEMARREVQLKA 364
+ IYFI+ + G+ I ++ +A+ V N + +KE EE R+++ A
Sbjct: 723 SFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTA 782
Query: 365 DMFKRQIIQRRKNMSHEALTSSHSKIEDRGASQQRESLDLSEVS 408
K+Q + + + S KIE + + ES ++++
Sbjct: 783 SPEKKQELVEKPAVGE----SKEEKIELKSITADGESPPATKIN 822
Score = 71.6 bits (174), Expect = 2e-12
Identities = 60/300 (20%), Positives = 136/300 (45%), Gaps = 52/300 (17%)
Query: 103 WVLECPLFKNFIIFLVFLNTIILMVE-----------IELLESTNTKLWPLKLTLEVAAW 151
+V+ F+ + L+ LNTI L ++ + +L T L+ +++ L++ A+
Sbjct: 1234 YVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAF 1293
Query: 152 ------------FILLIFILEILLKWLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGV 199
F LI I I+ LS + ++ AWN FD ++ + S++ + V
Sbjct: 1294 KPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNP 1353
Query: 200 TGQS-------------VWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLM 246
+ + + R+ RV+R +KLL++ I+ ++ +++ +++ ++ +
Sbjct: 1354 AEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVAL 1413
Query: 247 LLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHW----YAL 302
L+++ F+I+AV G+ VF + + ++ + F P +++ +F T + W A
Sbjct: 1414 LIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLAC 1473
Query: 303 LQDVWKVPE------------VSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKE 350
+ PE F+ YFI + +L + + ++ VA+++ NF + ++
Sbjct: 1474 MPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRD 1533
Score = 70.9 bits (172), Expect = 3e-12
Identities = 69/320 (21%), Positives = 138/320 (43%), Gaps = 62/320 (19%)
Query: 104 VLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILL 163
++E F+ I+ +F N + L + I E + LE + L+IF +E L
Sbjct: 120 IVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNAT---NSNLERVEYLFLIIFTVEAFL 176
Query: 164 KWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVV---------LVGVTGQSVWLQLL 209
K ++ +F +A WN+ DF++ ++ L ++ +G G ++ L
Sbjct: 177 KVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKAL 236
Query: 210 RICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------ 263
R RVLR L+L++ +Q+++ +++A+ + + +L+L I+A+ G+ +F
Sbjct: 237 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296
Query: 264 ------------SEYTRSP--------RQ-----------DLEYH--VFFSDLPNSLVTV 290
+E SP RQ D H F + +++TV
Sbjct: 297 TCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTV 356
Query: 291 FILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKE 350
F T++ W +L W V R + IYF+ +++GS ++++ ++ F R++
Sbjct: 357 FQCITMEGWTDVL--YWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREK 414
Query: 351 LNE----EMARREVQLKADM 366
+ R + QL+ D+
Sbjct: 415 AKARGDFQKLREKQQLEEDL 434
Score = 55.8 bits (133), Expect = 9e-08
Identities = 59/296 (19%), Positives = 133/296 (44%), Gaps = 65/296 (21%)
Query: 109 LFKNFIIFLVFLNTIILMVE------------IELLESTNTKLWPLKLTLEV---AAWFI 153
+F N I+F + L++I L E + + T ++ +++ L++ A +
Sbjct: 901 IFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKILGNADYVF 960
Query: 154 LLIFILEILLKWLS-----NFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV-WLQ 207
IF LEI+LK + + F ++ +N+ D +V +SL+ G+ ++ ++
Sbjct: 961 TSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLIS-----FGIQSSAINVVK 1015
Query: 208 LLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSE-- 265
+LR+ RVLR L+ + + + ++ ++ + A++++ ++++ + ++FA GV +F
Sbjct: 1016 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1075
Query: 266 YTRS----------------------------PRQDLEYHVFFSDLPNSLVTVFILFTLD 297
YT S PR F ++ +++ +F + T +
Sbjct: 1076 YTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFE 1135
Query: 298 HWYALL--------QDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQ 345
W LL +D + R+ SI+FI+++++ + +I V ++ FQ
Sbjct: 1136 GWPELLYRSIDSHTEDKGPIYNY-RVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQ 1190
>gi|120433602 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 18 [Homo sapiens]
Length = 2138
Score = 94.0 bits (232), Expect = 3e-19
Identities = 86/344 (25%), Positives = 154/344 (44%), Gaps = 32/344 (9%)
Query: 85 SRLHVRCSQRPPLSLWAGWVLECP----------LFKNFIIFLVFLNTIILMVEIELLES 134
+RL R S+ W W C +F +IFLVFLNT+ + E
Sbjct: 491 ARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASE-----H 545
Query: 135 TNTKLWPLKLTLEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSLLPEV 193
N W L + A +L +F E+LLK S ++ S +N FD V +L +
Sbjct: 546 YNQPNW-LTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETI 604
Query: 194 VVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFY 253
+V + + + +LR R+LR K+ + + ++ L+ +++S+ LL+LL +F
Sbjct: 605 LVETKIMSP-LGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFII 663
Query: 254 IFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQD---VWKVP 310
IF++ G+ +F F + P SL+TVF + T + W +++ D + P
Sbjct: 664 IFSLLGMQLFGGKFNFDEMQTRRSTF-DNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGP 722
Query: 311 EVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTN------FQNIRKELNEEMARREVQLKA 364
+ IYFI+ + G+ I ++ +A+ V N + +KE EE R+++ A
Sbjct: 723 SFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTA 782
Query: 365 DMFKRQIIQRRKNMSHEALTSSHSKIEDRGASQQRESLDLSEVS 408
K+Q + + + S KIE + + ES ++++
Sbjct: 783 SPEKKQELVEKPAVGE----SKEEKIELKSITADGESPPATKIN 822
Score = 70.9 bits (172), Expect = 3e-12
Identities = 69/320 (21%), Positives = 138/320 (43%), Gaps = 62/320 (19%)
Query: 104 VLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILL 163
++E F+ I+ +F N + L + I E + LE + L+IF +E L
Sbjct: 120 IVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNAT---NSNLERVEYLFLIIFTVEAFL 176
Query: 164 KWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVV---------LVGVTGQSVWLQLL 209
K ++ +F +A WN+ DF++ ++ L ++ +G G ++ L
Sbjct: 177 KVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKAL 236
Query: 210 RICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------ 263
R RVLR L+L++ +Q+++ +++A+ + + +L+L I+A+ G+ +F
Sbjct: 237 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296
Query: 264 ------------SEYTRSP--------RQ-----------DLEYH--VFFSDLPNSLVTV 290
+E SP RQ D H F + +++TV
Sbjct: 297 TCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTV 356
Query: 291 FILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKE 350
F T++ W +L W V R + IYF+ +++GS ++++ ++ F R++
Sbjct: 357 FQCITMEGWTDVL--YWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREK 414
Query: 351 LNE----EMARREVQLKADM 366
+ R + QL+ D+
Sbjct: 415 AKARGDFQKLREKQQLEEDL 434
Score = 68.9 bits (167), Expect = 1e-11
Identities = 53/278 (19%), Positives = 128/278 (46%), Gaps = 36/278 (12%)
Query: 103 WVLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEIL 162
+V+ F+ + L+ LNTI L ++ + K+ + + +F +E++
Sbjct: 1214 YVVNSTYFEYLMFVLILLNTICLAMQ------HYGQSCLFKIAMNILNMLFTGLFTVEMI 1267
Query: 163 LKWLS-NFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQS-------------VWLQL 208
LK ++ ++ AWN FD ++ + S++ + V + + +
Sbjct: 1268 LKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITF 1327
Query: 209 LRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTR 268
R+ RV+R +KLL++ I+ ++ +++ +++ ++ +L+++ F+I+AV G+ VF +
Sbjct: 1328 FRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIAL 1387
Query: 269 SPRQDLEYHVFFSDLPNSLVTVFILFTLDHW----YALLQDVWKVPE------------V 312
+ ++ + F P +++ +F T + W A + PE
Sbjct: 1388 NDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPC 1447
Query: 313 SRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKE 350
F+ YFI + +L + + ++ VA+++ NF + ++
Sbjct: 1448 GSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRD 1485
Score = 51.2 bits (121), Expect = 2e-06
Identities = 57/283 (20%), Positives = 125/283 (44%), Gaps = 59/283 (20%)
Query: 109 LFKNFIIFLVFLNTIILMVE--IELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWL 166
+F N I+F + L++I L E ++ N L+ + IF +EI LK
Sbjct: 901 IFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTT-------IFTIEIALKMT 953
Query: 167 S-----NFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV-WLQLLRICRVLRSLKL 220
+ + F ++ +N+ D +V +SL+ G+ ++ +++LR+ RVLR L+
Sbjct: 954 AYGAFLHKGSFCRNYFNILDLLVVSVSLIS-----FGIQSSAINVVKILRVLRVLRPLRA 1008
Query: 221 LAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSE--YTRS--------- 269
+ + + ++ ++ + A++++ ++++ + ++FA GV +F YT S
Sbjct: 1009 INRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAE 1068
Query: 270 -------------------PRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALL------- 303
PR F ++ +++ +F + T + W LL
Sbjct: 1069 CKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSH 1128
Query: 304 -QDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQ 345
+D + R+ SI+FI+++++ + +I V ++ FQ
Sbjct: 1129 TEDKGPIYNY-RVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQ 1170
>gi|193788548 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 20 [Homo sapiens]
Length = 2127
Score = 94.0 bits (232), Expect = 3e-19
Identities = 86/344 (25%), Positives = 154/344 (44%), Gaps = 32/344 (9%)
Query: 85 SRLHVRCSQRPPLSLWAGWVLECP----------LFKNFIIFLVFLNTIILMVEIELLES 134
+RL R S+ W W C +F +IFLVFLNT+ + E
Sbjct: 491 ARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASE-----H 545
Query: 135 TNTKLWPLKLTLEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSLLPEV 193
N W L + A +L +F E+LLK S ++ S +N FD V +L +
Sbjct: 546 YNQPNW-LTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETI 604
Query: 194 VVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFY 253
+V + + + +LR R+LR K+ + + ++ L+ +++S+ LL+LL +F
Sbjct: 605 LVETKIMSP-LGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFII 663
Query: 254 IFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQD---VWKVP 310
IF++ G+ +F F + P SL+TVF + T + W +++ D + P
Sbjct: 664 IFSLLGMQLFGGKFNFDEMQTRRSTF-DNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGP 722
Query: 311 EVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTN------FQNIRKELNEEMARREVQLKA 364
+ IYFI+ + G+ I ++ +A+ V N + +KE EE R+++ A
Sbjct: 723 SFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTA 782
Query: 365 DMFKRQIIQRRKNMSHEALTSSHSKIEDRGASQQRESLDLSEVS 408
K+Q + + + S KIE + + ES ++++
Sbjct: 783 SPEKKQELVEKPAVGE----SKEEKIELKSITADGESPPATKIN 822
Score = 73.6 bits (179), Expect = 4e-13
Identities = 53/267 (19%), Positives = 129/267 (48%), Gaps = 25/267 (9%)
Query: 103 WVLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEIL 162
+V+ F+ + L+ LNTI L ++ + K+ + + +F +E++
Sbjct: 1214 YVVNSTYFEYLMFVLILLNTICLAMQ------HYGQSCLFKIAMNILNMLFTGLFTVEMI 1267
Query: 163 LKWLS-NFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQS--VWLQLLRICRVLRSLK 219
LK ++ ++ AWN FD ++ + S++ + V ++ + + R+ RV+R +K
Sbjct: 1268 LKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRLVK 1327
Query: 220 LLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHVF 279
LL++ I+ ++ +++ +++ ++ +L+++ F+I+AV G+ VF + + ++ +
Sbjct: 1328 LLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNN 1387
Query: 280 FSDLPNSLVTVFILFTLDHW----YALLQDVWKVPE------------VSRIFSSIYFIL 323
F P +++ +F T + W A + PE F+ YFI
Sbjct: 1388 FQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFIS 1447
Query: 324 WLLLGSIIFRSIIVAMMVTNFQNIRKE 350
+ +L + + ++ VA+++ NF + ++
Sbjct: 1448 FYMLCAFLIINLFVAVIMDNFDYLTRD 1474
Score = 70.9 bits (172), Expect = 3e-12
Identities = 69/320 (21%), Positives = 138/320 (43%), Gaps = 62/320 (19%)
Query: 104 VLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILL 163
++E F+ I+ +F N + L + I E + LE + L+IF +E L
Sbjct: 120 IVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNAT---NSNLERVEYLFLIIFTVEAFL 176
Query: 164 KWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVV---------LVGVTGQSVWLQLL 209
K ++ +F +A WN+ DF++ ++ L ++ +G G ++ L
Sbjct: 177 KVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKAL 236
Query: 210 RICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------ 263
R RVLR L+L++ +Q+++ +++A+ + + +L+L I+A+ G+ +F
Sbjct: 237 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296
Query: 264 ------------SEYTRSP--------RQ-----------DLEYH--VFFSDLPNSLVTV 290
+E SP RQ D H F + +++TV
Sbjct: 297 TCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTV 356
Query: 291 FILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKE 350
F T++ W +L W V R + IYF+ +++GS ++++ ++ F R++
Sbjct: 357 FQCITMEGWTDVL--YWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREK 414
Query: 351 LNE----EMARREVQLKADM 366
+ R + QL+ D+
Sbjct: 415 AKARGDFQKLREKQQLEEDL 434
Score = 55.1 bits (131), Expect = 2e-07
Identities = 59/281 (20%), Positives = 129/281 (45%), Gaps = 55/281 (19%)
Query: 109 LFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWLS- 167
+F N I+F + L++I L E + ++ T+ + L A + IF LEI+LK +
Sbjct: 901 IFTNLILFFILLSSISLAAE-DPVQHTSFR----NHILGNADYVFTSIFTLEIILKMTAY 955
Query: 168 ----NFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV-WLQLLRICRVLRSLKLLA 222
+ F ++ +N+ D +V +SL+ G+ ++ +++LR+ RVLR L+ +
Sbjct: 956 GAFLHKGSFCRNYFNILDLLVVSVSLIS-----FGIQSSAINVVKILRVLRVLRPLRAIN 1010
Query: 223 QFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSE--YTRS----------- 269
+ + ++ ++ + A++++ ++++ + ++FA GV +F YT S
Sbjct: 1011 RAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECK 1070
Query: 270 -----------------PRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALL--------Q 304
PR F ++ +++ +F + T + W LL +
Sbjct: 1071 GNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTE 1130
Query: 305 DVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQ 345
D + R+ SI+FI+++++ + +I V ++ FQ
Sbjct: 1131 DKGPIYNY-RVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQ 1170
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.325 0.136 0.397
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,898,573
Number of Sequences: 37866
Number of extensions: 670700
Number of successful extensions: 5834
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 115
Number of HSP's successfully gapped in prelim test: 138
Number of HSP's that attempted gapping in prelim test: 4352
Number of HSP's gapped (non-prelim): 842
length of query: 528
length of database: 18,247,518
effective HSP length: 107
effective length of query: 421
effective length of database: 14,195,856
effective search space: 5976455376
effective search space used: 5976455376
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.