Guide to the Human Genome
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Search of human proteins with 16876443

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|16876443 sperm-associated cation channel 2 isoform 1 [Homo
sapiens]
         (528 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|16876443 sperm-associated cation channel 2 isoform 1 [Homo sa...  1028   0.0  
gi|26051223 sperm-associated cation channel 2 isoform 2 [Homo sa...  1023   0.0  
gi|26051227 sperm-associated cation channel 2 isoform 4 [Homo sa...   374   e-103
gi|150417969 voltage-gated sodium channel type V alpha isoform d...   100   4e-21
gi|4502523 calcium channel, voltage-dependent, N type, alpha 1B ...   100   6e-21
gi|20070163 voltage-dependent calcium channel alpha 1G subunit i...    99   7e-21
gi|38505284 voltage-dependent calcium channel alpha 1G subunit i...    99   7e-21
gi|38505282 voltage-dependent calcium channel alpha 1G subunit i...    99   7e-21
gi|38505280 voltage-dependent calcium channel alpha 1G subunit i...    99   7e-21
gi|38505278 voltage-dependent calcium channel alpha 1G subunit i...    99   7e-21
gi|38505270 voltage-dependent calcium channel alpha 1G subunit i...    99   7e-21
gi|62988334 cation channel, sperm associated 4 [Homo sapiens]          98   2e-20
gi|38505292 voltage-dependent calcium channel alpha 1G subunit i...    98   2e-20
gi|38505288 voltage-dependent calcium channel alpha 1G subunit i...    98   2e-20
gi|38505276 voltage-dependent calcium channel alpha 1G subunit i...    98   2e-20
gi|38505274 voltage-dependent calcium channel alpha 1G subunit i...    98   2e-20
gi|38505272 voltage-dependent calcium channel alpha 1G subunit i...    98   2e-20
gi|38505268 voltage-dependent calcium channel alpha 1G subunit i...    98   2e-20
gi|38505290 voltage-dependent calcium channel alpha 1G subunit i...    97   5e-20
gi|38505286 voltage-dependent calcium channel alpha 1G subunit i...    97   5e-20
gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H...    96   1e-19
gi|53832009 calcium channel, voltage-dependent, T type, alpha 1H...    96   1e-19
gi|53832005 calcium channel, voltage-dependent, R type, alpha 1E...    95   1e-19
gi|193788732 calcium channel, voltage-dependent, L type, alpha 1...    94   3e-19
gi|193788730 calcium channel, voltage-dependent, L type, alpha 1...    94   3e-19
gi|193788728 calcium channel, voltage-dependent, L type, alpha 1...    94   3e-19
gi|193788724 calcium channel, voltage-dependent, L type, alpha 1...    94   3e-19
gi|193788720 calcium channel, voltage-dependent, L type, alpha 1...    94   3e-19
gi|120433602 calcium channel, voltage-dependent, L type, alpha 1...    94   3e-19
gi|193788548 calcium channel, voltage-dependent, L type, alpha 1...    94   3e-19

>gi|16876443 sperm-associated cation channel 2 isoform 1 [Homo
           sapiens]
          Length = 528

 Score = 1028 bits (2657), Expect = 0.0
 Identities = 528/528 (100%), Positives = 528/528 (100%)

Query: 1   MAAYQQEEQMQLPRADAIRSRLIDTFSLIEHLQGLSQAVPRHTIRELLDPSRQKKLVLGD 60
           MAAYQQEEQMQLPRADAIRSRLIDTFSLIEHLQGLSQAVPRHTIRELLDPSRQKKLVLGD
Sbjct: 1   MAAYQQEEQMQLPRADAIRSRLIDTFSLIEHLQGLSQAVPRHTIRELLDPSRQKKLVLGD 60

Query: 61  QHQLVRFSIKPQRIEQISHAQRLLSRLHVRCSQRPPLSLWAGWVLECPLFKNFIIFLVFL 120
           QHQLVRFSIKPQRIEQISHAQRLLSRLHVRCSQRPPLSLWAGWVLECPLFKNFIIFLVFL
Sbjct: 61  QHQLVRFSIKPQRIEQISHAQRLLSRLHVRCSQRPPLSLWAGWVLECPLFKNFIIFLVFL 120

Query: 121 NTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWLSNFSVFWKSAWNVF 180
           NTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWLSNFSVFWKSAWNVF
Sbjct: 121 NTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWLSNFSVFWKSAWNVF 180

Query: 181 DFVVTMLSLLPEVVVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKS 240
           DFVVTMLSLLPEVVVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKS
Sbjct: 181 DFVVTMLSLLPEVVVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKS 240

Query: 241 MTFLLMLLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWY 300
           MTFLLMLLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWY
Sbjct: 241 MTFLLMLLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWY 300

Query: 301 ALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREV 360
           ALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREV
Sbjct: 301 ALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREV 360

Query: 361 QLKADMFKRQIIQRRKNMSHEALTSSHSKIEDRGASQQRESLDLSEVSEVESNYGATEED 420
           QLKADMFKRQIIQRRKNMSHEALTSSHSKIEDRGASQQRESLDLSEVSEVESNYGATEED
Sbjct: 361 QLKADMFKRQIIQRRKNMSHEALTSSHSKIEDRGASQQRESLDLSEVSEVESNYGATEED 420

Query: 421 LITSASKTEETLSKKREYQSSSCVSSTSSSYSSSSESRFSESIGRLDWETLVHENLPGLM 480
           LITSASKTEETLSKKREYQSSSCVSSTSSSYSSSSESRFSESIGRLDWETLVHENLPGLM
Sbjct: 421 LITSASKTEETLSKKREYQSSSCVSSTSSSYSSSSESRFSESIGRLDWETLVHENLPGLM 480

Query: 481 EMDQDDRVWPRDSLFRYFELLEKLQYNLEERKKLQEFAVQALMNLEDK 528
           EMDQDDRVWPRDSLFRYFELLEKLQYNLEERKKLQEFAVQALMNLEDK
Sbjct: 481 EMDQDDRVWPRDSLFRYFELLEKLQYNLEERKKLQEFAVQALMNLEDK 528


>gi|26051223 sperm-associated cation channel 2 isoform 2 [Homo
           sapiens]
          Length = 530

 Score = 1023 bits (2644), Expect = 0.0
 Identities = 528/530 (99%), Positives = 528/530 (99%), Gaps = 2/530 (0%)

Query: 1   MAAYQQEEQMQLPRADAIRSRLIDTFSLIEHLQGLSQAVPRHTIRELLDPSRQKKLVLGD 60
           MAAYQQEEQMQLPRADAIRSRLIDTFSLIEHLQGLSQAVPRHTIRELLDPSRQKKLVLGD
Sbjct: 1   MAAYQQEEQMQLPRADAIRSRLIDTFSLIEHLQGLSQAVPRHTIRELLDPSRQKKLVLGD 60

Query: 61  QHQLVRFSIKPQRIEQISHAQRLLSRLHVRCSQRPPLSLWAGWVLECPLFKNFIIFLVFL 120
           QHQLVRFSIKPQRIEQISHAQRLLSRLHVRCSQRPPLSLWAGWVLECPLFKNFIIFLVFL
Sbjct: 61  QHQLVRFSIKPQRIEQISHAQRLLSRLHVRCSQRPPLSLWAGWVLECPLFKNFIIFLVFL 120

Query: 121 NTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWLSNFSVFWKSAWNVF 180
           NTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWLSNFSVFWKSAWNVF
Sbjct: 121 NTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWLSNFSVFWKSAWNVF 180

Query: 181 DFVVTMLSLLPEVVVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKS 240
           DFVVTMLSLLPEVVVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKS
Sbjct: 181 DFVVTMLSLLPEVVVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKS 240

Query: 241 MTFLLMLLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWY 300
           MTFLLMLLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWY
Sbjct: 241 MTFLLMLLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWY 300

Query: 301 ALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREV 360
           ALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREV
Sbjct: 301 ALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREV 360

Query: 361 QLKADMFKRQIIQRRKNMSHEALTSSHSKIED--RGASQQRESLDLSEVSEVESNYGATE 418
           QLKADMFKRQIIQRRKNMSHEALTSSHSKIED  RGASQQRESLDLSEVSEVESNYGATE
Sbjct: 361 QLKADMFKRQIIQRRKNMSHEALTSSHSKIEDSSRGASQQRESLDLSEVSEVESNYGATE 420

Query: 419 EDLITSASKTEETLSKKREYQSSSCVSSTSSSYSSSSESRFSESIGRLDWETLVHENLPG 478
           EDLITSASKTEETLSKKREYQSSSCVSSTSSSYSSSSESRFSESIGRLDWETLVHENLPG
Sbjct: 421 EDLITSASKTEETLSKKREYQSSSCVSSTSSSYSSSSESRFSESIGRLDWETLVHENLPG 480

Query: 479 LMEMDQDDRVWPRDSLFRYFELLEKLQYNLEERKKLQEFAVQALMNLEDK 528
           LMEMDQDDRVWPRDSLFRYFELLEKLQYNLEERKKLQEFAVQALMNLEDK
Sbjct: 481 LMEMDQDDRVWPRDSLFRYFELLEKLQYNLEERKKLQEFAVQALMNLEDK 530


>gi|26051227 sperm-associated cation channel 2 isoform 4 [Homo
           sapiens]
          Length = 199

 Score =  374 bits (959), Expect = e-103
 Identities = 187/187 (100%), Positives = 187/187 (100%)

Query: 1   MAAYQQEEQMQLPRADAIRSRLIDTFSLIEHLQGLSQAVPRHTIRELLDPSRQKKLVLGD 60
           MAAYQQEEQMQLPRADAIRSRLIDTFSLIEHLQGLSQAVPRHTIRELLDPSRQKKLVLGD
Sbjct: 1   MAAYQQEEQMQLPRADAIRSRLIDTFSLIEHLQGLSQAVPRHTIRELLDPSRQKKLVLGD 60

Query: 61  QHQLVRFSIKPQRIEQISHAQRLLSRLHVRCSQRPPLSLWAGWVLECPLFKNFIIFLVFL 120
           QHQLVRFSIKPQRIEQISHAQRLLSRLHVRCSQRPPLSLWAGWVLECPLFKNFIIFLVFL
Sbjct: 61  QHQLVRFSIKPQRIEQISHAQRLLSRLHVRCSQRPPLSLWAGWVLECPLFKNFIIFLVFL 120

Query: 121 NTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWLSNFSVFWKSAWNVF 180
           NTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWLSNFSVFWKSAWNVF
Sbjct: 121 NTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWLSNFSVFWKSAWNVF 180

Query: 181 DFVVTML 187
           DFVVTML
Sbjct: 181 DFVVTML 187


>gi|150417969 voltage-gated sodium channel type V alpha isoform d
            [Homo sapiens]
          Length = 1998

 Score =  100 bits (248), Expect = 4e-21
 Identities = 74/267 (27%), Positives = 141/267 (52%), Gaps = 24/267 (8%)

Query: 104  VLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILL 163
            ++E   F+ FIIF++ L++  L  E   LE   T    +K+ LE A      +F+LE+LL
Sbjct: 1201 IVEHSWFETFIIFMILLSSGALAFEDIYLEERKT----IKVLLEYADKMFTYVFVLEMLL 1256

Query: 164  KWLS-NFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRICRVLRSLKLLA 222
            KW++  F  ++ +AW   DF++  +SL+  V   +G       ++ LR  R LR L+ L+
Sbjct: 1257 KWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGP-IKSLRTLRALRPLRALS 1315

Query: 223  QFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFS-EYTRSPRQ-----DLEY 276
            +F  +++++  LV A+ S+  +L++ LIF+ IF++ GV +F+ ++ R   Q      L Y
Sbjct: 1316 RFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNY 1375

Query: 277  HVFFS-------DLPNSLVTVFILFTLDH----WYALLQDVWKVPEVS-RIFSSIYFILW 324
             +  +       +L   L    +    D+    + ALLQ   + P+    ++  IYF+++
Sbjct: 1376 TIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVYEEQPQWEYNLYMYIYFVIF 1435

Query: 325  LLLGSIIFRSIIVAMMVTNFQNIRKEL 351
            ++ GS    ++ + +++ NF   +K+L
Sbjct: 1436 IIFGSFFTLNLFIGVIIDNFNQQKKKL 1462



 Score = 73.2 bits (178), Expect = 6e-13
 Identities = 69/348 (19%), Positives = 165/348 (47%), Gaps = 41/348 (11%)

Query: 47   LLDPSRQKKLVLGDQHQLVRFSIKPQRIEQISHAQRLLSRLHVRCSQRP---PLSLWAGW 103
            ++D   Q+K  LG Q   +         E+       + +L  +  Q+P   PL+ + G+
Sbjct: 1451 IIDNFNQQKKKLGGQDIFMT--------EEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGF 1502

Query: 104  VLECPLFKNF---IIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILE 160
            + +    + F   I+FL+ LN + +MVE +  + +  K+    +  ++   F+  IF  E
Sbjct: 1503 IFDIVTKQAFDVTIMFLICLNMVTMMVETD--DQSPEKI---NILAKINLLFVA-IFTGE 1556

Query: 161  ILLKWLSNFSVFWKSAWNVFDFVVTMLSLLPEVV--VLVGVTGQSVWLQLLRICRVLRSL 218
             ++K  +    ++ ++WN+FDFVV +LS++  V+  ++          +++R+ R+ R L
Sbjct: 1557 CIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRIL 1616

Query: 219  KLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHV 278
            +L+   + I+ ++  L+ +L ++  + +LL +  +I+++ G+  F+        D  ++ 
Sbjct: 1617 RLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFN- 1675

Query: 279  FFSDLPNSLVTVFILFTLDHWYALLQDVWKV------PEV-----------SRIFSSIYF 321
             F    NS++ +F + T   W  LL  +         P +           S     ++F
Sbjct: 1676 -FQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFF 1734

Query: 322  ILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADMFKR 369
              ++++  +I  ++ +A+++ NF    +E  E ++  +  +  +++++
Sbjct: 1735 TTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEK 1782



 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 93/431 (21%), Positives = 180/431 (41%), Gaps = 78/431 (18%)

Query: 114  IIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWLS-NFSVF 172
            I   + LNT+ + +E   + S   ++      L+V       IF  E+  K ++ +   +
Sbjct: 723  ITMCIVLNTLFMALEHYNMTSEFEEM------LQVGNLVFTGIFTAEMTFKIIALDPYYY 776

Query: 173  WKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQIQIIIL 232
            ++  WN+FD ++ +LSL+      +G++  S  L +LR  R+LR  KL   +  +  +I 
Sbjct: 777  FQQGWNIFDSIIVILSLME-----LGLSRMSN-LSVLRSFRLLRVFKLAKSWPTLNTLIK 830

Query: 233  VLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSE---YTRSPRQDLEYHVFFSDLPNSLVT 289
            ++  ++ ++  L ++L I  +IFAV G+ +F +     R     L       D  ++ + 
Sbjct: 831  IIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLI 890

Query: 290  VFILFTLDHWYALLQDVWKVPEVS-RIFSSIYFILWLLLGSIIFRSIIVAMMVTNF---- 344
            +F +     W   ++ +W   EVS +    + F+L +++G+++  ++ +A+++++F    
Sbjct: 891  IFRIL-CGEW---IETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADN 946

Query: 345  ----QNIRKELNEEMARREVQLKADMFKRQI------IQRRKNMSHEAL----------- 383
                   R+  N ++A   +Q      KR        + R++     AL           
Sbjct: 947  LTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIA 1006

Query: 384  ---------------TSSHSKIEDRGASQQRESLDLSEV----SEVESNYGATEEDLITS 424
                           T   ++ E+     Q    D   V    +  ES+    EED   S
Sbjct: 1007 TPYSPPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENS 1066

Query: 425  ASKTEETLSKKREYQ----------SSSCVSSTSSSYSSSSESRFSESIGRLDWETLVHE 474
               TEE  SK++E Q           S   S  S++ SS +E+  S++  R  W+     
Sbjct: 1067 LG-TEEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWK--AEP 1123

Query: 475  NLPGLMEMDQD 485
              PG  E  +D
Sbjct: 1124 QAPGCGETPED 1134



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 68/271 (25%), Positives = 116/271 (42%), Gaps = 51/271 (18%)

Query: 6   QEEQMQLPRADAIRSRLIDTFSLIEHLQGLSQAVPRHTIRELL---DP--SRQKK-LVLG 59
           QE +  LP  +A R +L       + L  L    P+  I E L   DP  S QK  +VL 
Sbjct: 40  QESREGLPEEEAPRPQL--DLQASKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLN 97

Query: 60  DQHQLVRFSIKPQRIEQISHAQRLLSRLHVRCSQRPPLSLWAGWVLECPLFKNFIIFLVF 119
               + RFS         ++A  +LS  H       P+   A  +L   LF N +I    
Sbjct: 98  KGKTIFRFSA--------TNALYVLSPFH-------PIRRAAVKILVHSLF-NMLIMCTI 141

Query: 120 LNTIILMVE------IELLESTNTKLWPLKLTLEVAA-WFILLIFILEILLKWLSNFSVF 172
           L   + M +       + +E T T ++  +  +++ A  F L  F              F
Sbjct: 142 LTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLHAF-------------TF 188

Query: 173 WKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQIQIIIL 232
            +  WN  DF V +++ + E + L         L  LR  RVLR+LK ++    ++ I+ 
Sbjct: 189 LRDPWNWLDFSVIIMAYVSENIKLGN-------LSALRTFRVLRALKTISVIPGLKTIVG 241

Query: 233 VLVRALKSMTFLLMLLLIFFYIFAVTGVYVF 263
            L++++K +  +++L +    +FA+ G+ +F
Sbjct: 242 ALIQSVKKLADVMVLTVFCLSVFALIGLQLF 272



 Score = 35.0 bits (79), Expect = 0.17
 Identities = 32/135 (23%), Positives = 61/135 (45%), Gaps = 18/135 (13%)

Query: 280 FSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAM 339
           F     + + +F L T D W  L Q   +     +I+  I+F+L + LGS    ++I+A+
Sbjct: 355 FDSFAWAFLALFRLMTQDCWERLYQQTLR--SAGKIYM-IFFMLVIFLGSFYLVNLILAV 411

Query: 340 MVTNFQNIRKELNEEMARREVQLKADMFKRQIIQRRKNMSHEALTSSHSKIEDRGA-SQQ 398
           +   +              E Q +A + + +  ++R   + E L   H  +  RG  +  
Sbjct: 412 VAMAY--------------EEQNQATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVS 457

Query: 399 RESLDLSEVSEVESN 413
           R SL++S ++ V S+
Sbjct: 458 RSSLEMSPLAPVNSH 472


>gi|4502523 calcium channel, voltage-dependent, N type, alpha 1B
            subunit [Homo sapiens]
          Length = 2339

 Score = 99.8 bits (247), Expect = 6e-21
 Identities = 64/254 (25%), Positives = 129/254 (50%), Gaps = 18/254 (7%)

Query: 108  PLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWLS 167
            P F+ FI+ ++ LNT++LM++           +  +L L+        +F +E +LK ++
Sbjct: 1471 PPFEYFIMAMIALNTVVLMMKFY------DAPYEYELMLKCLNIVFTSMFSMECVLKIIA 1524

Query: 168  NFSV--FWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRICRVLRSLKLLAQFR 225
             F V  +++ AWNVFDFV  + S+   +V  +  T   + L  LR+ R  R +KLL Q  
Sbjct: 1525 -FGVLNYFRDAWNVFDFVTVLGSITDILVTEIAETNNFINLSFLRLFRAARLIKLLRQGY 1583

Query: 226  QIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPN 285
             I+I++   V++ K++ ++ +L+ + F+I+A+ G+ VF          +  H  F     
Sbjct: 1584 TIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQ 1643

Query: 286  SLVTVFILFTLDHWYALL---------QDVWKVPEVSRIFSSIYFILWLLLGSIIFRSII 336
            +L+ +F   T + W+ ++          +     E    F+  YF+ ++ L S +  ++ 
Sbjct: 1644 ALMLLFRSATGEAWHEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLCSFLMLNLF 1703

Query: 337  VAMMVTNFQNIRKE 350
            VA+++ NF+ + ++
Sbjct: 1704 VAVIMDNFEYLTRD 1717



 Score = 86.3 bits (212), Expect = 6e-17
 Identities = 67/241 (27%), Positives = 125/241 (51%), Gaps = 11/241 (4%)

Query: 142 LKLTLEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVT 200
           L  TL  A +  L +F+ E+ LK        +++S++N FDF V + S+  EVV      
Sbjct: 510 LTTTLYFAEFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSVF-EVVWAAIKP 568

Query: 201 GQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGV 260
           G S  + +LR  R+LR  K+   +  ++ +++ L+ ++KS+  LL LL +F  +FA+ G+
Sbjct: 569 GSSFGISVLRALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGM 628

Query: 261 YVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALL-QDVWKVPEVSR-IFSS 318
            +F        QD      F   P +++TVF + T + W A++   +     VS+ +FSS
Sbjct: 629 QLFGGQFNF--QDETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVSKGMFSS 686

Query: 319 IYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADMFKRQIIQRRKNM 378
            YFI+  L G+    ++ +A+ V N  N      +E+ + E +++    ++  +Q+ K +
Sbjct: 687 FYFIVLTLFGNYTLLNVFLAIAVDNLANA-----QELTKDEEEMEEAANQKLALQKAKEV 741

Query: 379 S 379
           +
Sbjct: 742 A 742



 Score = 70.1 bits (170), Expect = 5e-12
 Identities = 66/329 (20%), Positives = 146/329 (44%), Gaps = 54/329 (16%)

Query: 103  WVLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEIL 162
            +++    F+  I+ ++ L++I L  E  +   +     P    L+   +    +F  E++
Sbjct: 1145 YIVTMRYFEVVILVVIALSSIALAAEDPVRTDS-----PRNNALKYLDYIFTGVFTFEMV 1199

Query: 163  LKWLS-----NFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV-WLQLLRICRVLR 216
            +K +      +   +++  WN+ DF+V   +L+       G  G+ +  ++ LR+ RVLR
Sbjct: 1200 IKMIDLGLLLHPGAYFRDLWNILDFIVVSGALV--AFAFSGSKGKDINTIKSLRVLRVLR 1257

Query: 217  SLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------------- 263
             LK + +  +++ +   +V +LK++  +L++ ++F +IFAV  V +F             
Sbjct: 1258 PLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKE 1317

Query: 264  --------------SEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKV 309
                           E    PRQ  +Y   + ++  +L+T+F + T + W  +L+     
Sbjct: 1318 LERDCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDA 1377

Query: 310  PEVS-------RIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQ----NIRKELNEEMARR 358
                       R+  SI+++++ ++    F +I VA+++  FQ     +  E + E   R
Sbjct: 1378 TYEEQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKVMSECSLEKNER 1437

Query: 359  ---EVQLKADMFKRQIIQRRKNMSHEALT 384
               +  + A    R + Q R++  ++  T
Sbjct: 1438 ACIDFAISAKPLTRYMPQNRQSFQYKTWT 1466



 Score = 69.7 bits (169), Expect = 6e-12
 Identities = 84/396 (21%), Positives = 162/396 (40%), Gaps = 73/396 (18%)

Query: 100 WAGWVLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFIL 159
           +A  + E P F+  I+  +  N I+L +E  L +   T   P+   L+    + + IF  
Sbjct: 87  YAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKT---PMSERLDDTEPYFIGIFCF 143

Query: 160 EILLKWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRICRV 214
           E  +K ++   VF K +     WNV DFVV +  +L          G    L+ LR  RV
Sbjct: 144 EAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGIL-------ATAGTDFDLRTLRAVRV 196

Query: 215 LRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF----------- 263
           LR LKL++    +Q+++  +++A+  +  + +LL     +FA+ G+  +           
Sbjct: 197 LRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPN 256

Query: 264 ---------------------------SEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTL 296
                                       EY   P   +     F ++  +++TVF   T+
Sbjct: 257 STDAEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGI---TNFDNILFAILTVFQCITM 313

Query: 297 DHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMA 356
           + W  +L +          ++ +YFI  +++GS    ++++ ++   F   R+ +    A
Sbjct: 314 EGWTDILYNT--NDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRA 371

Query: 357 ----RREVQLKADM--FKRQIIQRRKNMSHEALTSSHSK----IEDRGASQQRESLDLSE 406
               RR+ Q++ ++  +   I +  + M  E   ++  K    +  R A+++  + DL  
Sbjct: 372 FLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDRNAEEKSPLDVLKRAATKKSRN-DLIH 430

Query: 407 VSEVESNYGATEEDLITSASKTEETLSKKREYQSSS 442
             E E  +     DL    S       K  + +SSS
Sbjct: 431 AEEGEDRFA----DLCAVGSPFARASLKSGKTESSS 462


>gi|20070163 voltage-dependent calcium channel alpha 1G subunit
            isoform 1 [Homo sapiens]
          Length = 2377

 Score = 99.4 bits (246), Expect = 7e-21
 Identities = 68/321 (21%), Positives = 162/321 (50%), Gaps = 40/321 (12%)

Query: 109  LFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLK---- 164
            +F + ++ ++FLN I + +E   ++  + +    ++ L ++ +    +F+ E+ +K    
Sbjct: 1277 MFDHVVLVIIFLNCITIAMERPKIDPHSAE----RIFLTLSNYIFTAVFLAEMTVKVVAL 1332

Query: 165  -WLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV--WLQLLRICRVLRSLKLL 221
             W      + +S+WNV D ++ ++S++  +V +V  +G  +   L++LR+ R LR L+++
Sbjct: 1333 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1392

Query: 222  AQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------------------ 263
            ++ + +++++  L+ +LK +  ++++   FF IF + GV +F                  
Sbjct: 1393 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNK 1452

Query: 264  SEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRI-------F 316
            S+   +  + + +   F +L  +L+++F+L + D W  ++ D      V +        +
Sbjct: 1453 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1512

Query: 317  SSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADMFKRQIIQRRK 376
              +YFI +LL+ +    ++ V ++V NF   R+   EE ARR  + +     R++ ++R+
Sbjct: 1513 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL----RRLEKKRR 1568

Query: 377  NMSHEALTSSHSKIEDRGASQ 397
            N+  + + +S S       +Q
Sbjct: 1569 NLMLDDVIASGSSASAASEAQ 1589



 Score = 92.8 bits (229), Expect = 7e-19
 Identities = 58/234 (24%), Positives = 123/234 (52%), Gaps = 14/234 (5%)

Query: 146  LEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSL----LPEVVVLVGVT 200
            L++  +   +IF+LE + K ++  F  F++  WN  D  + +LS+    L E+ V   + 
Sbjct: 1643 LKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLP 1702

Query: 201  GQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGV 260
                 ++++R+ R+ R LKLL     ++ ++  +++AL  +  L +L ++ F+IFA  GV
Sbjct: 1703 INPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGV 1762

Query: 261  YVFSEY---TRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPE-----V 312
             +F +       P + L  H  F +   + +T+F + T D+W  +++D  +  +      
Sbjct: 1763 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1822

Query: 313  SRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADM 366
            + + S IYF+ ++L    +  ++++A+++ + +   KE  EE A  E +L+ +M
Sbjct: 1823 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE-AELEAELELEM 1875



 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 76/270 (28%), Positives = 138/270 (51%), Gaps = 21/270 (7%)

Query: 96  PLSLWAGWVLECPLFKNFIIFLVFLNTIILMVEIELLE-STNTKLWPLKLT--LEVAAWF 152
           P S+ A W L C  F+  +    F   I++ + +  L         P +LT  LE++   
Sbjct: 722 PSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIV 781

Query: 153 ILLIFILEILLKWLSNFSV-FWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRI 211
              +F LE+LLK L      + K+ +N+FD V+ ++S    V  +VG  G    L +LR 
Sbjct: 782 FTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVIS----VWEIVGQQGGG--LSVLRT 835

Query: 212 CRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPR 271
            R++R LKL+     +Q  ++VL++ + ++    MLL++F +IF++ G+++F     S R
Sbjct: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASER 895

Query: 272 --QDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGS 329
               L     F  L  ++VTVF + T + W  +L   +     +  ++++YFI  +  G+
Sbjct: 896 DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVL---YNGMASTSSWAALYFIALMTFGN 952

Query: 330 IIFRSIIVAMMVTNFQNIRKELNEEMARRE 359
            +  +++VA++V  FQ       EE+++RE
Sbjct: 953 YVLFNLLVAILVEGFQ------AEEISKRE 976



 Score = 49.3 bits (116), Expect = 9e-06
 Identities = 32/123 (26%), Positives = 63/123 (51%), Gaps = 11/123 (8%)

Query: 152 FILLIFILEILLKWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVVLVGVTGQSVWL 206
           FI   F +E+++K ++   +F K       WN  DF + +  +L   + L     Q+V  
Sbjct: 123 FIFAFFAVEMVVKMVA-LGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDL-----QNVSF 176

Query: 207 QLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEY 266
             +R  RVLR L+ + +   ++I++ +L+  L  +  +L+L    F+IF + GV +++  
Sbjct: 177 SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236

Query: 267 TRS 269
            R+
Sbjct: 237 LRN 239



 Score = 37.0 bits (84), Expect = 0.045
 Identities = 17/82 (20%), Positives = 44/82 (53%), Gaps = 3/82 (3%)

Query: 280 FSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAM 339
           F ++  + + +F + TL+ W  ++   + V +    ++ IYFIL +++GS    ++ + +
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIM---YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVV 393

Query: 340 MVTNFQNIRKELNEEMARREVQ 361
           + T F   ++  ++ M  + V+
Sbjct: 394 IATQFSETKQRESQLMREQRVR 415


>gi|38505284 voltage-dependent calcium channel alpha 1G subunit
            isoform 4 [Homo sapiens]
          Length = 2332

 Score = 99.4 bits (246), Expect = 7e-21
 Identities = 68/321 (21%), Positives = 162/321 (50%), Gaps = 40/321 (12%)

Query: 109  LFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLK---- 164
            +F + ++ ++FLN I + +E   ++  + +    ++ L ++ +    +F+ E+ +K    
Sbjct: 1277 MFDHVVLVIIFLNCITIAMERPKIDPHSAE----RIFLTLSNYIFTAVFLAEMTVKVVAL 1332

Query: 165  -WLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV--WLQLLRICRVLRSLKLL 221
             W      + +S+WNV D ++ ++S++  +V +V  +G  +   L++LR+ R LR L+++
Sbjct: 1333 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1392

Query: 222  AQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------------------ 263
            ++ + +++++  L+ +LK +  ++++   FF IF + GV +F                  
Sbjct: 1393 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNK 1452

Query: 264  SEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRI-------F 316
            S+   +  + + +   F +L  +L+++F+L + D W  ++ D      V +        +
Sbjct: 1453 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1512

Query: 317  SSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADMFKRQIIQRRK 376
              +YFI +LL+ +    ++ V ++V NF   R+   EE ARR  + +     R++ ++R+
Sbjct: 1513 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL----RRLEKKRR 1568

Query: 377  NMSHEALTSSHSKIEDRGASQ 397
            N+  + + +S S       +Q
Sbjct: 1569 NLMLDDVIASGSSASAASEAQ 1589



 Score = 92.8 bits (229), Expect = 7e-19
 Identities = 58/234 (24%), Positives = 123/234 (52%), Gaps = 14/234 (5%)

Query: 146  LEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSL----LPEVVVLVGVT 200
            L++  +   +IF+LE + K ++  F  F++  WN  D  + +LS+    L E+ V   + 
Sbjct: 1643 LKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLP 1702

Query: 201  GQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGV 260
                 ++++R+ R+ R LKLL     ++ ++  +++AL  +  L +L ++ F+IFA  GV
Sbjct: 1703 INPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGV 1762

Query: 261  YVFSEY---TRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPE-----V 312
             +F +       P + L  H  F +   + +T+F + T D+W  +++D  +  +      
Sbjct: 1763 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1822

Query: 313  SRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADM 366
            + + S IYF+ ++L    +  ++++A+++ + +   KE  EE A  E +L+ +M
Sbjct: 1823 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE-AELEAELELEM 1875



 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 76/270 (28%), Positives = 138/270 (51%), Gaps = 21/270 (7%)

Query: 96  PLSLWAGWVLECPLFKNFIIFLVFLNTIILMVEIELLE-STNTKLWPLKLT--LEVAAWF 152
           P S+ A W L C  F+  +    F   I++ + +  L         P +LT  LE++   
Sbjct: 722 PSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIV 781

Query: 153 ILLIFILEILLKWLSNFSV-FWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRI 211
              +F LE+LLK L      + K+ +N+FD V+ ++S    V  +VG  G    L +LR 
Sbjct: 782 FTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVIS----VWEIVGQQGGG--LSVLRT 835

Query: 212 CRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPR 271
            R++R LKL+     +Q  ++VL++ + ++    MLL++F +IF++ G+++F     S R
Sbjct: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASER 895

Query: 272 --QDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGS 329
               L     F  L  ++VTVF + T + W  +L   +     +  ++++YFI  +  G+
Sbjct: 896 DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVL---YNGMASTSSWAALYFIALMTFGN 952

Query: 330 IIFRSIIVAMMVTNFQNIRKELNEEMARRE 359
            +  +++VA++V  FQ       EE+++RE
Sbjct: 953 YVLFNLLVAILVEGFQ------AEEISKRE 976



 Score = 49.3 bits (116), Expect = 9e-06
 Identities = 32/123 (26%), Positives = 63/123 (51%), Gaps = 11/123 (8%)

Query: 152 FILLIFILEILLKWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVVLVGVTGQSVWL 206
           FI   F +E+++K ++   +F K       WN  DF + +  +L   + L     Q+V  
Sbjct: 123 FIFAFFAVEMVVKMVA-LGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDL-----QNVSF 176

Query: 207 QLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEY 266
             +R  RVLR L+ + +   ++I++ +L+  L  +  +L+L    F+IF + GV +++  
Sbjct: 177 SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236

Query: 267 TRS 269
            R+
Sbjct: 237 LRN 239



 Score = 37.0 bits (84), Expect = 0.045
 Identities = 17/82 (20%), Positives = 44/82 (53%), Gaps = 3/82 (3%)

Query: 280 FSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAM 339
           F ++  + + +F + TL+ W  ++   + V +    ++ IYFIL +++GS    ++ + +
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIM---YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVV 393

Query: 340 MVTNFQNIRKELNEEMARREVQ 361
           + T F   ++  ++ M  + V+
Sbjct: 394 IATQFSETKQRESQLMREQRVR 415


>gi|38505282 voltage-dependent calcium channel alpha 1G subunit
            isoform 8 [Homo sapiens]
          Length = 2284

 Score = 99.4 bits (246), Expect = 7e-21
 Identities = 68/321 (21%), Positives = 162/321 (50%), Gaps = 40/321 (12%)

Query: 109  LFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLK---- 164
            +F + ++ ++FLN I + +E   ++  + +    ++ L ++ +    +F+ E+ +K    
Sbjct: 1277 MFDHVVLVIIFLNCITIAMERPKIDPHSAE----RIFLTLSNYIFTAVFLAEMTVKVVAL 1332

Query: 165  -WLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV--WLQLLRICRVLRSLKLL 221
             W      + +S+WNV D ++ ++S++  +V +V  +G  +   L++LR+ R LR L+++
Sbjct: 1333 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1392

Query: 222  AQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------------------ 263
            ++ + +++++  L+ +LK +  ++++   FF IF + GV +F                  
Sbjct: 1393 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNK 1452

Query: 264  SEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRI-------F 316
            S+   +  + + +   F +L  +L+++F+L + D W  ++ D      V +        +
Sbjct: 1453 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1512

Query: 317  SSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADMFKRQIIQRRK 376
              +YFI +LL+ +    ++ V ++V NF   R+   EE ARR  + +     R++ ++R+
Sbjct: 1513 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL----RRLEKKRR 1568

Query: 377  NMSHEALTSSHSKIEDRGASQ 397
            N+  + + +S S       +Q
Sbjct: 1569 NLMLDDVIASGSSASAASEAQ 1589



 Score = 92.8 bits (229), Expect = 7e-19
 Identities = 58/234 (24%), Positives = 123/234 (52%), Gaps = 14/234 (5%)

Query: 146  LEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSL----LPEVVVLVGVT 200
            L++  +   +IF+LE + K ++  F  F++  WN  D  + +LS+    L E+ V   + 
Sbjct: 1643 LKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLP 1702

Query: 201  GQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGV 260
                 ++++R+ R+ R LKLL     ++ ++  +++AL  +  L +L ++ F+IFA  GV
Sbjct: 1703 INPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGV 1762

Query: 261  YVFSEY---TRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPE-----V 312
             +F +       P + L  H  F +   + +T+F + T D+W  +++D  +  +      
Sbjct: 1763 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1822

Query: 313  SRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADM 366
            + + S IYF+ ++L    +  ++++A+++ + +   KE  EE A  E +L+ +M
Sbjct: 1823 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE-AELEAELELEM 1875



 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 76/270 (28%), Positives = 138/270 (51%), Gaps = 21/270 (7%)

Query: 96  PLSLWAGWVLECPLFKNFIIFLVFLNTIILMVEIELLE-STNTKLWPLKLT--LEVAAWF 152
           P S+ A W L C  F+  +    F   I++ + +  L         P +LT  LE++   
Sbjct: 722 PSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIV 781

Query: 153 ILLIFILEILLKWLSNFSV-FWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRI 211
              +F LE+LLK L      + K+ +N+FD V+ ++S    V  +VG  G    L +LR 
Sbjct: 782 FTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVIS----VWEIVGQQGGG--LSVLRT 835

Query: 212 CRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPR 271
            R++R LKL+     +Q  ++VL++ + ++    MLL++F +IF++ G+++F     S R
Sbjct: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASER 895

Query: 272 --QDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGS 329
               L     F  L  ++VTVF + T + W  +L   +     +  ++++YFI  +  G+
Sbjct: 896 DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVL---YNGMASTSSWAALYFIALMTFGN 952

Query: 330 IIFRSIIVAMMVTNFQNIRKELNEEMARRE 359
            +  +++VA++V  FQ       EE+++RE
Sbjct: 953 YVLFNLLVAILVEGFQ------AEEISKRE 976



 Score = 49.3 bits (116), Expect = 9e-06
 Identities = 32/123 (26%), Positives = 63/123 (51%), Gaps = 11/123 (8%)

Query: 152 FILLIFILEILLKWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVVLVGVTGQSVWL 206
           FI   F +E+++K ++   +F K       WN  DF + +  +L   + L     Q+V  
Sbjct: 123 FIFAFFAVEMVVKMVA-LGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDL-----QNVSF 176

Query: 207 QLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEY 266
             +R  RVLR L+ + +   ++I++ +L+  L  +  +L+L    F+IF + GV +++  
Sbjct: 177 SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236

Query: 267 TRS 269
            R+
Sbjct: 237 LRN 239



 Score = 37.0 bits (84), Expect = 0.045
 Identities = 17/82 (20%), Positives = 44/82 (53%), Gaps = 3/82 (3%)

Query: 280 FSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAM 339
           F ++  + + +F + TL+ W  ++   + V +    ++ IYFIL +++GS    ++ + +
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIM---YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVV 393

Query: 340 MVTNFQNIRKELNEEMARREVQ 361
           + T F   ++  ++ M  + V+
Sbjct: 394 IATQFSETKQRESQLMREQRVR 415


>gi|38505280 voltage-dependent calcium channel alpha 1G subunit
            isoform 6 [Homo sapiens]
          Length = 2306

 Score = 99.4 bits (246), Expect = 7e-21
 Identities = 68/321 (21%), Positives = 162/321 (50%), Gaps = 40/321 (12%)

Query: 109  LFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLK---- 164
            +F + ++ ++FLN I + +E   ++  + +    ++ L ++ +    +F+ E+ +K    
Sbjct: 1254 MFDHVVLVIIFLNCITIAMERPKIDPHSAE----RIFLTLSNYIFTAVFLAEMTVKVVAL 1309

Query: 165  -WLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV--WLQLLRICRVLRSLKLL 221
             W      + +S+WNV D ++ ++S++  +V +V  +G  +   L++LR+ R LR L+++
Sbjct: 1310 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1369

Query: 222  AQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------------------ 263
            ++ + +++++  L+ +LK +  ++++   FF IF + GV +F                  
Sbjct: 1370 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNK 1429

Query: 264  SEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRI-------F 316
            S+   +  + + +   F +L  +L+++F+L + D W  ++ D      V +        +
Sbjct: 1430 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1489

Query: 317  SSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADMFKRQIIQRRK 376
              +YFI +LL+ +    ++ V ++V NF   R+   EE ARR  + +     R++ ++R+
Sbjct: 1490 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL----RRLEKKRR 1545

Query: 377  NMSHEALTSSHSKIEDRGASQ 397
            N+  + + +S S       +Q
Sbjct: 1546 NLMLDDVIASGSSASAASEAQ 1566



 Score = 92.8 bits (229), Expect = 7e-19
 Identities = 58/234 (24%), Positives = 123/234 (52%), Gaps = 14/234 (5%)

Query: 146  LEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSL----LPEVVVLVGVT 200
            L++  +   +IF+LE + K ++  F  F++  WN  D  + +LS+    L E+ V   + 
Sbjct: 1620 LKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLP 1679

Query: 201  GQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGV 260
                 ++++R+ R+ R LKLL     ++ ++  +++AL  +  L +L ++ F+IFA  GV
Sbjct: 1680 INPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGV 1739

Query: 261  YVFSEY---TRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPE-----V 312
             +F +       P + L  H  F +   + +T+F + T D+W  +++D  +  +      
Sbjct: 1740 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1799

Query: 313  SRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADM 366
            + + S IYF+ ++L    +  ++++A+++ + +   KE  EE A  E +L+ +M
Sbjct: 1800 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE-AELEAELELEM 1852



 Score = 86.3 bits (212), Expect = 6e-17
 Identities = 72/256 (28%), Positives = 131/256 (51%), Gaps = 15/256 (5%)

Query: 96  PLSLWAGWVLECPLFKNFIIFLVFLNTIILMVEIELLE-STNTKLWPLKLT--LEVAAWF 152
           P S+ A W L C  F+  +    F   I++ + +  L         P +LT  LE++   
Sbjct: 722 PSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIV 781

Query: 153 ILLIFILEILLKWLSNFSV-FWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRI 211
              +F LE+LLK L      + K+ +N+FD V+ ++S    V  +VG  G    L +LR 
Sbjct: 782 FTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVIS----VWEIVGQQGGG--LSVLRT 835

Query: 212 CRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPR 271
            R++R LKL+     +Q  ++VL++ + ++    MLL++F +IF++ G+++F     S R
Sbjct: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASER 895

Query: 272 --QDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGS 329
               L     F  L  ++VTVF + T + W  +L   +     +  ++++YFI  +  G+
Sbjct: 896 DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVL---YNGMASTSSWAALYFIALMTFGN 952

Query: 330 IIFRSIIVAMMVTNFQ 345
            +  +++VA++V  FQ
Sbjct: 953 YVLFNLLVAILVEGFQ 968



 Score = 49.3 bits (116), Expect = 9e-06
 Identities = 32/123 (26%), Positives = 63/123 (51%), Gaps = 11/123 (8%)

Query: 152 FILLIFILEILLKWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVVLVGVTGQSVWL 206
           FI   F +E+++K ++   +F K       WN  DF + +  +L   + L     Q+V  
Sbjct: 123 FIFAFFAVEMVVKMVA-LGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDL-----QNVSF 176

Query: 207 QLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEY 266
             +R  RVLR L+ + +   ++I++ +L+  L  +  +L+L    F+IF + GV +++  
Sbjct: 177 SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236

Query: 267 TRS 269
            R+
Sbjct: 237 LRN 239



 Score = 37.0 bits (84), Expect = 0.045
 Identities = 17/82 (20%), Positives = 44/82 (53%), Gaps = 3/82 (3%)

Query: 280 FSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAM 339
           F ++  + + +F + TL+ W  ++   + V +    ++ IYFIL +++GS    ++ + +
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIM---YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVV 393

Query: 340 MVTNFQNIRKELNEEMARREVQ 361
           + T F   ++  ++ M  + V+
Sbjct: 394 IATQFSETKQRESQLMREQRVR 415


>gi|38505278 voltage-dependent calcium channel alpha 1G subunit
            isoform 11 [Homo sapiens]
          Length = 2261

 Score = 99.4 bits (246), Expect = 7e-21
 Identities = 68/321 (21%), Positives = 162/321 (50%), Gaps = 40/321 (12%)

Query: 109  LFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLK---- 164
            +F + ++ ++FLN I + +E   ++  + +    ++ L ++ +    +F+ E+ +K    
Sbjct: 1254 MFDHVVLVIIFLNCITIAMERPKIDPHSAE----RIFLTLSNYIFTAVFLAEMTVKVVAL 1309

Query: 165  -WLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV--WLQLLRICRVLRSLKLL 221
             W      + +S+WNV D ++ ++S++  +V +V  +G  +   L++LR+ R LR L+++
Sbjct: 1310 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1369

Query: 222  AQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------------------ 263
            ++ + +++++  L+ +LK +  ++++   FF IF + GV +F                  
Sbjct: 1370 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNK 1429

Query: 264  SEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRI-------F 316
            S+   +  + + +   F +L  +L+++F+L + D W  ++ D      V +        +
Sbjct: 1430 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1489

Query: 317  SSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADMFKRQIIQRRK 376
              +YFI +LL+ +    ++ V ++V NF   R+   EE ARR  + +     R++ ++R+
Sbjct: 1490 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL----RRLEKKRR 1545

Query: 377  NMSHEALTSSHSKIEDRGASQ 397
            N+  + + +S S       +Q
Sbjct: 1546 NLMLDDVIASGSSASAASEAQ 1566



 Score = 92.8 bits (229), Expect = 7e-19
 Identities = 58/234 (24%), Positives = 123/234 (52%), Gaps = 14/234 (5%)

Query: 146  LEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSL----LPEVVVLVGVT 200
            L++  +   +IF+LE + K ++  F  F++  WN  D  + +LS+    L E+ V   + 
Sbjct: 1620 LKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLP 1679

Query: 201  GQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGV 260
                 ++++R+ R+ R LKLL     ++ ++  +++AL  +  L +L ++ F+IFA  GV
Sbjct: 1680 INPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGV 1739

Query: 261  YVFSEY---TRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPE-----V 312
             +F +       P + L  H  F +   + +T+F + T D+W  +++D  +  +      
Sbjct: 1740 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1799

Query: 313  SRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADM 366
            + + S IYF+ ++L    +  ++++A+++ + +   KE  EE A  E +L+ +M
Sbjct: 1800 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE-AELEAELELEM 1852



 Score = 86.3 bits (212), Expect = 6e-17
 Identities = 72/256 (28%), Positives = 131/256 (51%), Gaps = 15/256 (5%)

Query: 96  PLSLWAGWVLECPLFKNFIIFLVFLNTIILMVEIELLE-STNTKLWPLKLT--LEVAAWF 152
           P S+ A W L C  F+  +    F   I++ + +  L         P +LT  LE++   
Sbjct: 722 PSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIV 781

Query: 153 ILLIFILEILLKWLSNFSV-FWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRI 211
              +F LE+LLK L      + K+ +N+FD V+ ++S    V  +VG  G    L +LR 
Sbjct: 782 FTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVIS----VWEIVGQQGGG--LSVLRT 835

Query: 212 CRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPR 271
            R++R LKL+     +Q  ++VL++ + ++    MLL++F +IF++ G+++F     S R
Sbjct: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASER 895

Query: 272 --QDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGS 329
               L     F  L  ++VTVF + T + W  +L   +     +  ++++YFI  +  G+
Sbjct: 896 DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVL---YNGMASTSSWAALYFIALMTFGN 952

Query: 330 IIFRSIIVAMMVTNFQ 345
            +  +++VA++V  FQ
Sbjct: 953 YVLFNLLVAILVEGFQ 968



 Score = 49.3 bits (116), Expect = 9e-06
 Identities = 32/123 (26%), Positives = 63/123 (51%), Gaps = 11/123 (8%)

Query: 152 FILLIFILEILLKWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVVLVGVTGQSVWL 206
           FI   F +E+++K ++   +F K       WN  DF + +  +L   + L     Q+V  
Sbjct: 123 FIFAFFAVEMVVKMVA-LGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDL-----QNVSF 176

Query: 207 QLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEY 266
             +R  RVLR L+ + +   ++I++ +L+  L  +  +L+L    F+IF + GV +++  
Sbjct: 177 SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236

Query: 267 TRS 269
            R+
Sbjct: 237 LRN 239



 Score = 37.0 bits (84), Expect = 0.045
 Identities = 17/82 (20%), Positives = 44/82 (53%), Gaps = 3/82 (3%)

Query: 280 FSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAM 339
           F ++  + + +F + TL+ W  ++   + V +    ++ IYFIL +++GS    ++ + +
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIM---YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVV 393

Query: 340 MVTNFQNIRKELNEEMARREVQ 361
           + T F   ++  ++ M  + V+
Sbjct: 394 IATQFSETKQRESQLMREQRVR 415


>gi|38505270 voltage-dependent calcium channel alpha 1G subunit
            isoform 2 [Homo sapiens]
          Length = 2354

 Score = 99.4 bits (246), Expect = 7e-21
 Identities = 68/321 (21%), Positives = 162/321 (50%), Gaps = 40/321 (12%)

Query: 109  LFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLK---- 164
            +F + ++ ++FLN I + +E   ++  + +    ++ L ++ +    +F+ E+ +K    
Sbjct: 1254 MFDHVVLVIIFLNCITIAMERPKIDPHSAE----RIFLTLSNYIFTAVFLAEMTVKVVAL 1309

Query: 165  -WLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV--WLQLLRICRVLRSLKLL 221
             W      + +S+WNV D ++ ++S++  +V +V  +G  +   L++LR+ R LR L+++
Sbjct: 1310 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1369

Query: 222  AQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------------------ 263
            ++ + +++++  L+ +LK +  ++++   FF IF + GV +F                  
Sbjct: 1370 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNK 1429

Query: 264  SEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRI-------F 316
            S+   +  + + +   F +L  +L+++F+L + D W  ++ D      V +        +
Sbjct: 1430 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1489

Query: 317  SSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADMFKRQIIQRRK 376
              +YFI +LL+ +    ++ V ++V NF   R+   EE ARR  + +     R++ ++R+
Sbjct: 1490 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL----RRLEKKRR 1545

Query: 377  NMSHEALTSSHSKIEDRGASQ 397
            N+  + + +S S       +Q
Sbjct: 1546 NLMLDDVIASGSSASAASEAQ 1566



 Score = 92.8 bits (229), Expect = 7e-19
 Identities = 58/234 (24%), Positives = 123/234 (52%), Gaps = 14/234 (5%)

Query: 146  LEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSL----LPEVVVLVGVT 200
            L++  +   +IF+LE + K ++  F  F++  WN  D  + +LS+    L E+ V   + 
Sbjct: 1620 LKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLP 1679

Query: 201  GQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGV 260
                 ++++R+ R+ R LKLL     ++ ++  +++AL  +  L +L ++ F+IFA  GV
Sbjct: 1680 INPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGV 1739

Query: 261  YVFSEY---TRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPE-----V 312
             +F +       P + L  H  F +   + +T+F + T D+W  +++D  +  +      
Sbjct: 1740 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1799

Query: 313  SRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADM 366
            + + S IYF+ ++L    +  ++++A+++ + +   KE  EE A  E +L+ +M
Sbjct: 1800 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE-AELEAELELEM 1852



 Score = 86.3 bits (212), Expect = 6e-17
 Identities = 72/256 (28%), Positives = 131/256 (51%), Gaps = 15/256 (5%)

Query: 96  PLSLWAGWVLECPLFKNFIIFLVFLNTIILMVEIELLE-STNTKLWPLKLT--LEVAAWF 152
           P S+ A W L C  F+  +    F   I++ + +  L         P +LT  LE++   
Sbjct: 722 PSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIV 781

Query: 153 ILLIFILEILLKWLSNFSV-FWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRI 211
              +F LE+LLK L      + K+ +N+FD V+ ++S    V  +VG  G    L +LR 
Sbjct: 782 FTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVIS----VWEIVGQQGGG--LSVLRT 835

Query: 212 CRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPR 271
            R++R LKL+     +Q  ++VL++ + ++    MLL++F +IF++ G+++F     S R
Sbjct: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASER 895

Query: 272 --QDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGS 329
               L     F  L  ++VTVF + T + W  +L   +     +  ++++YFI  +  G+
Sbjct: 896 DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVL---YNGMASTSSWAALYFIALMTFGN 952

Query: 330 IIFRSIIVAMMVTNFQ 345
            +  +++VA++V  FQ
Sbjct: 953 YVLFNLLVAILVEGFQ 968



 Score = 49.3 bits (116), Expect = 9e-06
 Identities = 32/123 (26%), Positives = 63/123 (51%), Gaps = 11/123 (8%)

Query: 152 FILLIFILEILLKWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVVLVGVTGQSVWL 206
           FI   F +E+++K ++   +F K       WN  DF + +  +L   + L     Q+V  
Sbjct: 123 FIFAFFAVEMVVKMVA-LGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDL-----QNVSF 176

Query: 207 QLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEY 266
             +R  RVLR L+ + +   ++I++ +L+  L  +  +L+L    F+IF + GV +++  
Sbjct: 177 SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236

Query: 267 TRS 269
            R+
Sbjct: 237 LRN 239



 Score = 37.0 bits (84), Expect = 0.045
 Identities = 17/82 (20%), Positives = 44/82 (53%), Gaps = 3/82 (3%)

Query: 280 FSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAM 339
           F ++  + + +F + TL+ W  ++   + V +    ++ IYFIL +++GS    ++ + +
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIM---YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVV 393

Query: 340 MVTNFQNIRKELNEEMARREVQ 361
           + T F   ++  ++ M  + V+
Sbjct: 394 IATQFSETKQRESQLMREQRVR 415


>gi|62988334 cation channel, sperm associated 4 [Homo sapiens]
          Length = 472

 Score = 98.2 bits (243), Expect = 2e-20
 Identities = 64/248 (25%), Positives = 126/248 (50%), Gaps = 22/248 (8%)

Query: 104 VLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILL 163
           +L  P F+  +  L+ +N I + +        + K + L  T++     +L I + E+LL
Sbjct: 88  LLRHPAFQLLLALLLVINAITIALRTN--SYLDQKHYELFSTIDD---IVLTILLCEVLL 142

Query: 164 KWLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRICRVLRSLKLLAQ 223
            WL+ F +FWK  WN+ +F++  + LL   +  + +   +  L+ LR+  V  +++ LA+
Sbjct: 143 GWLNGFWIFWKDGWNILNFIIVFILLLRFFINEINIPSINYTLRALRLVHVCMAVEPLAR 202

Query: 224 FRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHVFFSDL 283
                 II V+++++  M  +++L+L F  +F+V GV +F  +   P+        F ++
Sbjct: 203 ------IIRVILQSVPDMANIMVLILFFMLVFSVFGVTLFGAFV--PKH-------FQNI 247

Query: 284 PNSLVTVFILFTLDHWYALLQD--VWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMV 341
             +L T+FI  T D W  +  D    K      I  +IYF +++ +G+ I  ++ V ++ 
Sbjct: 248 QVALYTLFICITQDGWVDIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGINLFVIVVT 307

Query: 342 TNFQNIRK 349
           TN + + K
Sbjct: 308 TNLEQMMK 315


>gi|38505292 voltage-dependent calcium channel alpha 1G subunit
            isoform 3 [Homo sapiens]
          Length = 2343

 Score = 97.8 bits (242), Expect = 2e-20
 Identities = 64/303 (21%), Positives = 153/303 (50%), Gaps = 36/303 (11%)

Query: 109  LFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLK---- 164
            +F + ++ ++FLN I + +E   ++  + +    ++ L ++ +    +F+ E+ +K    
Sbjct: 1254 MFDHVVLVIIFLNCITIAMERPKIDPHSAE----RIFLTLSNYIFTAVFLAEMTVKVVAL 1309

Query: 165  -WLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV--WLQLLRICRVLRSLKLL 221
             W      + +S+WNV D ++ ++S++  +V +V  +G  +   L++LR+ R LR L+++
Sbjct: 1310 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1369

Query: 222  AQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------------------ 263
            ++ + +++++  L+ +LK +  ++++   FF IF + GV +F                  
Sbjct: 1370 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNK 1429

Query: 264  SEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRI-------F 316
            S+   +  + + +   F +L  +L+++F+L + D W  ++ D      V +        +
Sbjct: 1430 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1489

Query: 317  SSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADMFKRQIIQRRK 376
              +YFI +LL+ +    ++ V ++V NF   R+   EE ARR  + +    +++   + K
Sbjct: 1490 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRSKEK 1549

Query: 377  NMS 379
             M+
Sbjct: 1550 QMA 1552



 Score = 92.8 bits (229), Expect = 7e-19
 Identities = 58/234 (24%), Positives = 123/234 (52%), Gaps = 14/234 (5%)

Query: 146  LEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSL----LPEVVVLVGVT 200
            L++  +   +IF+LE + K ++  F  F++  WN  D  + +LS+    L E+ V   + 
Sbjct: 1609 LKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLP 1668

Query: 201  GQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGV 260
                 ++++R+ R+ R LKLL     ++ ++  +++AL  +  L +L ++ F+IFA  GV
Sbjct: 1669 INPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGV 1728

Query: 261  YVFSEY---TRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPE-----V 312
             +F +       P + L  H  F +   + +T+F + T D+W  +++D  +  +      
Sbjct: 1729 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1788

Query: 313  SRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADM 366
            + + S IYF+ ++L    +  ++++A+++ + +   KE  EE A  E +L+ +M
Sbjct: 1789 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE-AELEAELELEM 1841



 Score = 86.3 bits (212), Expect = 6e-17
 Identities = 72/256 (28%), Positives = 131/256 (51%), Gaps = 15/256 (5%)

Query: 96  PLSLWAGWVLECPLFKNFIIFLVFLNTIILMVEIELLE-STNTKLWPLKLT--LEVAAWF 152
           P S+ A W L C  F+  +    F   I++ + +  L         P +LT  LE++   
Sbjct: 722 PSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIV 781

Query: 153 ILLIFILEILLKWLSNFSV-FWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRI 211
              +F LE+LLK L      + K+ +N+FD V+ ++S    V  +VG  G    L +LR 
Sbjct: 782 FTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVIS----VWEIVGQQGGG--LSVLRT 835

Query: 212 CRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPR 271
            R++R LKL+     +Q  ++VL++ + ++    MLL++F +IF++ G+++F     S R
Sbjct: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASER 895

Query: 272 --QDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGS 329
               L     F  L  ++VTVF + T + W  +L   +     +  ++++YFI  +  G+
Sbjct: 896 DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVL---YNGMASTSSWAALYFIALMTFGN 952

Query: 330 IIFRSIIVAMMVTNFQ 345
            +  +++VA++V  FQ
Sbjct: 953 YVLFNLLVAILVEGFQ 968



 Score = 49.3 bits (116), Expect = 9e-06
 Identities = 32/123 (26%), Positives = 63/123 (51%), Gaps = 11/123 (8%)

Query: 152 FILLIFILEILLKWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVVLVGVTGQSVWL 206
           FI   F +E+++K ++   +F K       WN  DF + +  +L   + L     Q+V  
Sbjct: 123 FIFAFFAVEMVVKMVA-LGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDL-----QNVSF 176

Query: 207 QLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEY 266
             +R  RVLR L+ + +   ++I++ +L+  L  +  +L+L    F+IF + GV +++  
Sbjct: 177 SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236

Query: 267 TRS 269
            R+
Sbjct: 237 LRN 239



 Score = 37.0 bits (84), Expect = 0.045
 Identities = 17/82 (20%), Positives = 44/82 (53%), Gaps = 3/82 (3%)

Query: 280 FSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAM 339
           F ++  + + +F + TL+ W  ++   + V +    ++ IYFIL +++GS    ++ + +
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIM---YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVV 393

Query: 340 MVTNFQNIRKELNEEMARREVQ 361
           + T F   ++  ++ M  + V+
Sbjct: 394 IATQFSETKQRESQLMREQRVR 415


>gi|38505288 voltage-dependent calcium channel alpha 1G subunit
            isoform 12 [Homo sapiens]
          Length = 2250

 Score = 97.8 bits (242), Expect = 2e-20
 Identities = 64/303 (21%), Positives = 153/303 (50%), Gaps = 36/303 (11%)

Query: 109  LFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLK---- 164
            +F + ++ ++FLN I + +E   ++  + +    ++ L ++ +    +F+ E+ +K    
Sbjct: 1254 MFDHVVLVIIFLNCITIAMERPKIDPHSAE----RIFLTLSNYIFTAVFLAEMTVKVVAL 1309

Query: 165  -WLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV--WLQLLRICRVLRSLKLL 221
             W      + +S+WNV D ++ ++S++  +V +V  +G  +   L++LR+ R LR L+++
Sbjct: 1310 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1369

Query: 222  AQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------------------ 263
            ++ + +++++  L+ +LK +  ++++   FF IF + GV +F                  
Sbjct: 1370 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNK 1429

Query: 264  SEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRI-------F 316
            S+   +  + + +   F +L  +L+++F+L + D W  ++ D      V +        +
Sbjct: 1430 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1489

Query: 317  SSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADMFKRQIIQRRK 376
              +YFI +LL+ +    ++ V ++V NF   R+   EE ARR  + +    +++   + K
Sbjct: 1490 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRSKEK 1549

Query: 377  NMS 379
             M+
Sbjct: 1550 QMA 1552



 Score = 92.8 bits (229), Expect = 7e-19
 Identities = 58/234 (24%), Positives = 123/234 (52%), Gaps = 14/234 (5%)

Query: 146  LEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSL----LPEVVVLVGVT 200
            L++  +   +IF+LE + K ++  F  F++  WN  D  + +LS+    L E+ V   + 
Sbjct: 1609 LKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLP 1668

Query: 201  GQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGV 260
                 ++++R+ R+ R LKLL     ++ ++  +++AL  +  L +L ++ F+IFA  GV
Sbjct: 1669 INPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGV 1728

Query: 261  YVFSEY---TRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPE-----V 312
             +F +       P + L  H  F +   + +T+F + T D+W  +++D  +  +      
Sbjct: 1729 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1788

Query: 313  SRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADM 366
            + + S IYF+ ++L    +  ++++A+++ + +   KE  EE A  E +L+ +M
Sbjct: 1789 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE-AELEAELELEM 1841



 Score = 86.3 bits (212), Expect = 6e-17
 Identities = 72/256 (28%), Positives = 131/256 (51%), Gaps = 15/256 (5%)

Query: 96  PLSLWAGWVLECPLFKNFIIFLVFLNTIILMVEIELLE-STNTKLWPLKLT--LEVAAWF 152
           P S+ A W L C  F+  +    F   I++ + +  L         P +LT  LE++   
Sbjct: 722 PSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIV 781

Query: 153 ILLIFILEILLKWLSNFSV-FWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRI 211
              +F LE+LLK L      + K+ +N+FD V+ ++S    V  +VG  G    L +LR 
Sbjct: 782 FTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVIS----VWEIVGQQGGG--LSVLRT 835

Query: 212 CRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPR 271
            R++R LKL+     +Q  ++VL++ + ++    MLL++F +IF++ G+++F     S R
Sbjct: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASER 895

Query: 272 --QDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGS 329
               L     F  L  ++VTVF + T + W  +L   +     +  ++++YFI  +  G+
Sbjct: 896 DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVL---YNGMASTSSWAALYFIALMTFGN 952

Query: 330 IIFRSIIVAMMVTNFQ 345
            +  +++VA++V  FQ
Sbjct: 953 YVLFNLLVAILVEGFQ 968



 Score = 49.3 bits (116), Expect = 9e-06
 Identities = 32/123 (26%), Positives = 63/123 (51%), Gaps = 11/123 (8%)

Query: 152 FILLIFILEILLKWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVVLVGVTGQSVWL 206
           FI   F +E+++K ++   +F K       WN  DF + +  +L   + L     Q+V  
Sbjct: 123 FIFAFFAVEMVVKMVA-LGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDL-----QNVSF 176

Query: 207 QLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEY 266
             +R  RVLR L+ + +   ++I++ +L+  L  +  +L+L    F+IF + GV +++  
Sbjct: 177 SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236

Query: 267 TRS 269
            R+
Sbjct: 237 LRN 239



 Score = 37.0 bits (84), Expect = 0.045
 Identities = 17/82 (20%), Positives = 44/82 (53%), Gaps = 3/82 (3%)

Query: 280 FSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAM 339
           F ++  + + +F + TL+ W  ++   + V +    ++ IYFIL +++GS    ++ + +
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIM---YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVV 393

Query: 340 MVTNFQNIRKELNEEMARREVQ 361
           + T F   ++  ++ M  + V+
Sbjct: 394 IATQFSETKQRESQLMREQRVR 415


>gi|38505276 voltage-dependent calcium channel alpha 1G subunit
            isoform 5 [Homo sapiens]
          Length = 2321

 Score = 97.8 bits (242), Expect = 2e-20
 Identities = 64/303 (21%), Positives = 153/303 (50%), Gaps = 36/303 (11%)

Query: 109  LFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLK---- 164
            +F + ++ ++FLN I + +E   ++  + +    ++ L ++ +    +F+ E+ +K    
Sbjct: 1277 MFDHVVLVIIFLNCITIAMERPKIDPHSAE----RIFLTLSNYIFTAVFLAEMTVKVVAL 1332

Query: 165  -WLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV--WLQLLRICRVLRSLKLL 221
             W      + +S+WNV D ++ ++S++  +V +V  +G  +   L++LR+ R LR L+++
Sbjct: 1333 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1392

Query: 222  AQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------------------ 263
            ++ + +++++  L+ +LK +  ++++   FF IF + GV +F                  
Sbjct: 1393 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNK 1452

Query: 264  SEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRI-------F 316
            S+   +  + + +   F +L  +L+++F+L + D W  ++ D      V +        +
Sbjct: 1453 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1512

Query: 317  SSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADMFKRQIIQRRK 376
              +YFI +LL+ +    ++ V ++V NF   R+   EE ARR  + +    +++   + K
Sbjct: 1513 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRSKEK 1572

Query: 377  NMS 379
             M+
Sbjct: 1573 QMA 1575



 Score = 92.8 bits (229), Expect = 7e-19
 Identities = 58/234 (24%), Positives = 123/234 (52%), Gaps = 14/234 (5%)

Query: 146  LEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSL----LPEVVVLVGVT 200
            L++  +   +IF+LE + K ++  F  F++  WN  D  + +LS+    L E+ V   + 
Sbjct: 1632 LKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLP 1691

Query: 201  GQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGV 260
                 ++++R+ R+ R LKLL     ++ ++  +++AL  +  L +L ++ F+IFA  GV
Sbjct: 1692 INPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGV 1751

Query: 261  YVFSEY---TRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPE-----V 312
             +F +       P + L  H  F +   + +T+F + T D+W  +++D  +  +      
Sbjct: 1752 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1811

Query: 313  SRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADM 366
            + + S IYF+ ++L    +  ++++A+++ + +   KE  EE A  E +L+ +M
Sbjct: 1812 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE-AELEAELELEM 1864



 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 76/270 (28%), Positives = 138/270 (51%), Gaps = 21/270 (7%)

Query: 96  PLSLWAGWVLECPLFKNFIIFLVFLNTIILMVEIELLE-STNTKLWPLKLT--LEVAAWF 152
           P S+ A W L C  F+  +    F   I++ + +  L         P +LT  LE++   
Sbjct: 722 PSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIV 781

Query: 153 ILLIFILEILLKWLSNFSV-FWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRI 211
              +F LE+LLK L      + K+ +N+FD V+ ++S    V  +VG  G    L +LR 
Sbjct: 782 FTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVIS----VWEIVGQQGGG--LSVLRT 835

Query: 212 CRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPR 271
            R++R LKL+     +Q  ++VL++ + ++    MLL++F +IF++ G+++F     S R
Sbjct: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASER 895

Query: 272 --QDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGS 329
               L     F  L  ++VTVF + T + W  +L   +     +  ++++YFI  +  G+
Sbjct: 896 DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVL---YNGMASTSSWAALYFIALMTFGN 952

Query: 330 IIFRSIIVAMMVTNFQNIRKELNEEMARRE 359
            +  +++VA++V  FQ       EE+++RE
Sbjct: 953 YVLFNLLVAILVEGFQ------AEEISKRE 976



 Score = 49.3 bits (116), Expect = 9e-06
 Identities = 32/123 (26%), Positives = 63/123 (51%), Gaps = 11/123 (8%)

Query: 152 FILLIFILEILLKWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVVLVGVTGQSVWL 206
           FI   F +E+++K ++   +F K       WN  DF + +  +L   + L     Q+V  
Sbjct: 123 FIFAFFAVEMVVKMVA-LGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDL-----QNVSF 176

Query: 207 QLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEY 266
             +R  RVLR L+ + +   ++I++ +L+  L  +  +L+L    F+IF + GV +++  
Sbjct: 177 SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236

Query: 267 TRS 269
            R+
Sbjct: 237 LRN 239



 Score = 37.0 bits (84), Expect = 0.045
 Identities = 17/82 (20%), Positives = 44/82 (53%), Gaps = 3/82 (3%)

Query: 280 FSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAM 339
           F ++  + + +F + TL+ W  ++   + V +    ++ IYFIL +++GS    ++ + +
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIM---YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVV 393

Query: 340 MVTNFQNIRKELNEEMARREVQ 361
           + T F   ++  ++ M  + V+
Sbjct: 394 IATQFSETKQRESQLMREQRVR 415


>gi|38505274 voltage-dependent calcium channel alpha 1G subunit
            isoform 7 [Homo sapiens]
          Length = 2298

 Score = 97.8 bits (242), Expect = 2e-20
 Identities = 64/303 (21%), Positives = 153/303 (50%), Gaps = 36/303 (11%)

Query: 109  LFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLK---- 164
            +F + ++ ++FLN I + +E   ++  + +    ++ L ++ +    +F+ E+ +K    
Sbjct: 1254 MFDHVVLVIIFLNCITIAMERPKIDPHSAE----RIFLTLSNYIFTAVFLAEMTVKVVAL 1309

Query: 165  -WLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV--WLQLLRICRVLRSLKLL 221
             W      + +S+WNV D ++ ++S++  +V +V  +G  +   L++LR+ R LR L+++
Sbjct: 1310 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1369

Query: 222  AQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------------------ 263
            ++ + +++++  L+ +LK +  ++++   FF IF + GV +F                  
Sbjct: 1370 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNK 1429

Query: 264  SEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRI-------F 316
            S+   +  + + +   F +L  +L+++F+L + D W  ++ D      V +        +
Sbjct: 1430 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1489

Query: 317  SSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADMFKRQIIQRRK 376
              +YFI +LL+ +    ++ V ++V NF   R+   EE ARR  + +    +++   + K
Sbjct: 1490 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRSKEK 1549

Query: 377  NMS 379
             M+
Sbjct: 1550 QMA 1552



 Score = 92.8 bits (229), Expect = 7e-19
 Identities = 58/234 (24%), Positives = 123/234 (52%), Gaps = 14/234 (5%)

Query: 146  LEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSL----LPEVVVLVGVT 200
            L++  +   +IF+LE + K ++  F  F++  WN  D  + +LS+    L E+ V   + 
Sbjct: 1609 LKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLP 1668

Query: 201  GQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGV 260
                 ++++R+ R+ R LKLL     ++ ++  +++AL  +  L +L ++ F+IFA  GV
Sbjct: 1669 INPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGV 1728

Query: 261  YVFSEY---TRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPE-----V 312
             +F +       P + L  H  F +   + +T+F + T D+W  +++D  +  +      
Sbjct: 1729 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1788

Query: 313  SRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADM 366
            + + S IYF+ ++L    +  ++++A+++ + +   KE  EE A  E +L+ +M
Sbjct: 1789 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE-AELEAELELEM 1841



 Score = 86.3 bits (212), Expect = 6e-17
 Identities = 72/256 (28%), Positives = 131/256 (51%), Gaps = 15/256 (5%)

Query: 96  PLSLWAGWVLECPLFKNFIIFLVFLNTIILMVEIELLE-STNTKLWPLKLT--LEVAAWF 152
           P S+ A W L C  F+  +    F   I++ + +  L         P +LT  LE++   
Sbjct: 722 PSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIV 781

Query: 153 ILLIFILEILLKWLSNFSV-FWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRI 211
              +F LE+LLK L      + K+ +N+FD V+ ++S    V  +VG  G    L +LR 
Sbjct: 782 FTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVIS----VWEIVGQQGGG--LSVLRT 835

Query: 212 CRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPR 271
            R++R LKL+     +Q  ++VL++ + ++    MLL++F +IF++ G+++F     S R
Sbjct: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASER 895

Query: 272 --QDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGS 329
               L     F  L  ++VTVF + T + W  +L   +     +  ++++YFI  +  G+
Sbjct: 896 DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVL---YNGMASTSSWAALYFIALMTFGN 952

Query: 330 IIFRSIIVAMMVTNFQ 345
            +  +++VA++V  FQ
Sbjct: 953 YVLFNLLVAILVEGFQ 968



 Score = 49.3 bits (116), Expect = 9e-06
 Identities = 32/123 (26%), Positives = 63/123 (51%), Gaps = 11/123 (8%)

Query: 152 FILLIFILEILLKWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVVLVGVTGQSVWL 206
           FI   F +E+++K ++   +F K       WN  DF + +  +L   + L     Q+V  
Sbjct: 123 FIFAFFAVEMVVKMVA-LGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDL-----QNVSF 176

Query: 207 QLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEY 266
             +R  RVLR L+ + +   ++I++ +L+  L  +  +L+L    F+IF + GV +++  
Sbjct: 177 SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236

Query: 267 TRS 269
            R+
Sbjct: 237 LRN 239



 Score = 37.0 bits (84), Expect = 0.045
 Identities = 17/82 (20%), Positives = 44/82 (53%), Gaps = 3/82 (3%)

Query: 280 FSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAM 339
           F ++  + + +F + TL+ W  ++   + V +    ++ IYFIL +++GS    ++ + +
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIM---YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVV 393

Query: 340 MVTNFQNIRKELNEEMARREVQ 361
           + T F   ++  ++ M  + V+
Sbjct: 394 IATQFSETKQRESQLMREQRVR 415


>gi|38505272 voltage-dependent calcium channel alpha 1G subunit
            isoform 9 [Homo sapiens]
          Length = 2273

 Score = 97.8 bits (242), Expect = 2e-20
 Identities = 64/303 (21%), Positives = 153/303 (50%), Gaps = 36/303 (11%)

Query: 109  LFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLK---- 164
            +F + ++ ++FLN I + +E   ++  + +    ++ L ++ +    +F+ E+ +K    
Sbjct: 1277 MFDHVVLVIIFLNCITIAMERPKIDPHSAE----RIFLTLSNYIFTAVFLAEMTVKVVAL 1332

Query: 165  -WLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV--WLQLLRICRVLRSLKLL 221
             W      + +S+WNV D ++ ++S++  +V +V  +G  +   L++LR+ R LR L+++
Sbjct: 1333 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1392

Query: 222  AQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------------------ 263
            ++ + +++++  L+ +LK +  ++++   FF IF + GV +F                  
Sbjct: 1393 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNK 1452

Query: 264  SEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRI-------F 316
            S+   +  + + +   F +L  +L+++F+L + D W  ++ D      V +        +
Sbjct: 1453 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1512

Query: 317  SSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADMFKRQIIQRRK 376
              +YFI +LL+ +    ++ V ++V NF   R+   EE ARR  + +    +++   + K
Sbjct: 1513 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRSKEK 1572

Query: 377  NMS 379
             M+
Sbjct: 1573 QMA 1575



 Score = 92.8 bits (229), Expect = 7e-19
 Identities = 58/234 (24%), Positives = 123/234 (52%), Gaps = 14/234 (5%)

Query: 146  LEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSL----LPEVVVLVGVT 200
            L++  +   +IF+LE + K ++  F  F++  WN  D  + +LS+    L E+ V   + 
Sbjct: 1632 LKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLP 1691

Query: 201  GQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGV 260
                 ++++R+ R+ R LKLL     ++ ++  +++AL  +  L +L ++ F+IFA  GV
Sbjct: 1692 INPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGV 1751

Query: 261  YVFSEY---TRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPE-----V 312
             +F +       P + L  H  F +   + +T+F + T D+W  +++D  +  +      
Sbjct: 1752 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1811

Query: 313  SRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADM 366
            + + S IYF+ ++L    +  ++++A+++ + +   KE  EE A  E +L+ +M
Sbjct: 1812 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE-AELEAELELEM 1864



 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 76/270 (28%), Positives = 138/270 (51%), Gaps = 21/270 (7%)

Query: 96  PLSLWAGWVLECPLFKNFIIFLVFLNTIILMVEIELLE-STNTKLWPLKLT--LEVAAWF 152
           P S+ A W L C  F+  +    F   I++ + +  L         P +LT  LE++   
Sbjct: 722 PSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIV 781

Query: 153 ILLIFILEILLKWLSNFSV-FWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRI 211
              +F LE+LLK L      + K+ +N+FD V+ ++S    V  +VG  G    L +LR 
Sbjct: 782 FTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVIS----VWEIVGQQGGG--LSVLRT 835

Query: 212 CRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPR 271
            R++R LKL+     +Q  ++VL++ + ++    MLL++F +IF++ G+++F     S R
Sbjct: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASER 895

Query: 272 --QDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGS 329
               L     F  L  ++VTVF + T + W  +L   +     +  ++++YFI  +  G+
Sbjct: 896 DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVL---YNGMASTSSWAALYFIALMTFGN 952

Query: 330 IIFRSIIVAMMVTNFQNIRKELNEEMARRE 359
            +  +++VA++V  FQ       EE+++RE
Sbjct: 953 YVLFNLLVAILVEGFQ------AEEISKRE 976



 Score = 49.3 bits (116), Expect = 9e-06
 Identities = 32/123 (26%), Positives = 63/123 (51%), Gaps = 11/123 (8%)

Query: 152 FILLIFILEILLKWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVVLVGVTGQSVWL 206
           FI   F +E+++K ++   +F K       WN  DF + +  +L   + L     Q+V  
Sbjct: 123 FIFAFFAVEMVVKMVA-LGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDL-----QNVSF 176

Query: 207 QLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEY 266
             +R  RVLR L+ + +   ++I++ +L+  L  +  +L+L    F+IF + GV +++  
Sbjct: 177 SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236

Query: 267 TRS 269
            R+
Sbjct: 237 LRN 239



 Score = 37.0 bits (84), Expect = 0.045
 Identities = 17/82 (20%), Positives = 44/82 (53%), Gaps = 3/82 (3%)

Query: 280 FSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAM 339
           F ++  + + +F + TL+ W  ++   + V +    ++ IYFIL +++GS    ++ + +
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIM---YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVV 393

Query: 340 MVTNFQNIRKELNEEMARREVQ 361
           + T F   ++  ++ M  + V+
Sbjct: 394 IATQFSETKQRESQLMREQRVR 415


>gi|38505268 voltage-dependent calcium channel alpha 1G subunit
            isoform 14 [Homo sapiens]
          Length = 2171

 Score = 97.8 bits (242), Expect = 2e-20
 Identities = 64/303 (21%), Positives = 153/303 (50%), Gaps = 36/303 (11%)

Query: 109  LFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLK---- 164
            +F + ++ ++FLN I + +E   ++  + +    ++ L ++ +    +F+ E+ +K    
Sbjct: 1254 MFDHVVLVIIFLNCITIAMERPKIDPHSAE----RIFLTLSNYIFTAVFLAEMTVKVVAL 1309

Query: 165  -WLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV--WLQLLRICRVLRSLKLL 221
             W      + +S+WNV D ++ ++S++  +V +V  +G  +   L++LR+ R LR L+++
Sbjct: 1310 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1369

Query: 222  AQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------------------ 263
            ++ + +++++  L+ +LK +  ++++   FF IF + GV +F                  
Sbjct: 1370 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNK 1429

Query: 264  SEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRI-------F 316
            S+   +  + + +   F +L  +L+++F+L + D W  ++ D      V +        +
Sbjct: 1430 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1489

Query: 317  SSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADMFKRQIIQRRK 376
              +YFI +LL+ +    ++ V ++V NF   R+   EE ARR  + +    +++   + K
Sbjct: 1490 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRSKEK 1549

Query: 377  NMS 379
             M+
Sbjct: 1550 QMA 1552



 Score = 92.8 bits (229), Expect = 7e-19
 Identities = 58/234 (24%), Positives = 123/234 (52%), Gaps = 14/234 (5%)

Query: 146  LEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSL----LPEVVVLVGVT 200
            L++  +   +IF+LE + K ++  F  F++  WN  D  + +LS+    L E+ V   + 
Sbjct: 1609 LKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLP 1668

Query: 201  GQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGV 260
                 ++++R+ R+ R LKLL     ++ ++  +++AL  +  L +L ++ F+IFA  GV
Sbjct: 1669 INPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGV 1728

Query: 261  YVFSEY---TRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPE-----V 312
             +F +       P + L  H  F +   + +T+F + T D+W  +++D  +  +      
Sbjct: 1729 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1788

Query: 313  SRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADM 366
            + + S IYF+ ++L    +  ++++A+++ + +   KE  EE A  E +L+ +M
Sbjct: 1789 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE-AELEAELELEM 1841



 Score = 86.3 bits (212), Expect = 6e-17
 Identities = 72/256 (28%), Positives = 131/256 (51%), Gaps = 15/256 (5%)

Query: 96  PLSLWAGWVLECPLFKNFIIFLVFLNTIILMVEIELLE-STNTKLWPLKLT--LEVAAWF 152
           P S+ A W L C  F+  +    F   I++ + +  L         P +LT  LE++   
Sbjct: 722 PSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIV 781

Query: 153 ILLIFILEILLKWLSNFSV-FWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRI 211
              +F LE+LLK L      + K+ +N+FD V+ ++S    V  +VG  G    L +LR 
Sbjct: 782 FTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVIS----VWEIVGQQGGG--LSVLRT 835

Query: 212 CRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPR 271
            R++R LKL+     +Q  ++VL++ + ++    MLL++F +IF++ G+++F     S R
Sbjct: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASER 895

Query: 272 --QDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGS 329
               L     F  L  ++VTVF + T + W  +L   +     +  ++++YFI  +  G+
Sbjct: 896 DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVL---YNGMASTSSWAALYFIALMTFGN 952

Query: 330 IIFRSIIVAMMVTNFQ 345
            +  +++VA++V  FQ
Sbjct: 953 YVLFNLLVAILVEGFQ 968



 Score = 49.3 bits (116), Expect = 9e-06
 Identities = 32/123 (26%), Positives = 63/123 (51%), Gaps = 11/123 (8%)

Query: 152 FILLIFILEILLKWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVVLVGVTGQSVWL 206
           FI   F +E+++K ++   +F K       WN  DF + +  +L   + L     Q+V  
Sbjct: 123 FIFAFFAVEMVVKMVA-LGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDL-----QNVSF 176

Query: 207 QLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEY 266
             +R  RVLR L+ + +   ++I++ +L+  L  +  +L+L    F+IF + GV +++  
Sbjct: 177 SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236

Query: 267 TRS 269
            R+
Sbjct: 237 LRN 239



 Score = 37.0 bits (84), Expect = 0.045
 Identities = 17/82 (20%), Positives = 44/82 (53%), Gaps = 3/82 (3%)

Query: 280 FSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAM 339
           F ++  + + +F + TL+ W  ++   + V +    ++ IYFIL +++GS    ++ + +
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIM---YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVV 393

Query: 340 MVTNFQNIRKELNEEMARREVQ 361
           + T F   ++  ++ M  + V+
Sbjct: 394 IATQFSETKQRESQLMREQRVR 415


>gi|38505290 voltage-dependent calcium channel alpha 1G subunit
            isoform 13 [Homo sapiens]
          Length = 2243

 Score = 96.7 bits (239), Expect = 5e-20
 Identities = 66/313 (21%), Positives = 158/313 (50%), Gaps = 40/313 (12%)

Query: 109  LFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLK---- 164
            +F + ++ ++FLN I + +E   ++  + +    ++ L ++ +    +F+ E+ +K    
Sbjct: 1254 MFDHVVLVIIFLNCITIAMERPKIDPHSAE----RIFLTLSNYIFTAVFLAEMTVKVVAL 1309

Query: 165  -WLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV--WLQLLRICRVLRSLKLL 221
             W      + +S+WNV D ++ ++S++  +V +V  +G  +   L++LR+ R LR L+++
Sbjct: 1310 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1369

Query: 222  AQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------------------ 263
            ++ + +++++  L+ +LK +  ++++   FF IF + GV +F                  
Sbjct: 1370 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNK 1429

Query: 264  SEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRI-------F 316
            S+   +  + + +   F +L  +L+++F+L + D W  ++ D      V +        +
Sbjct: 1430 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1489

Query: 317  SSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADMFKRQIIQRRK 376
              +YFI +LL+ +    ++ V ++V NF   R+   EE ARR  + +     R++ ++R+
Sbjct: 1490 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL----RRLEKKRR 1545

Query: 377  NMSHEALTSSHSK 389
                +   S +S+
Sbjct: 1546 KAQCKPYYSDYSR 1558



 Score = 92.8 bits (229), Expect = 7e-19
 Identities = 58/234 (24%), Positives = 123/234 (52%), Gaps = 14/234 (5%)

Query: 146  LEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSL----LPEVVVLVGVT 200
            L++  +   +IF+LE + K ++  F  F++  WN  D  + +LS+    L E+ V   + 
Sbjct: 1602 LKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLP 1661

Query: 201  GQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGV 260
                 ++++R+ R+ R LKLL     ++ ++  +++AL  +  L +L ++ F+IFA  GV
Sbjct: 1662 INPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGV 1721

Query: 261  YVFSEY---TRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPE-----V 312
             +F +       P + L  H  F +   + +T+F + T D+W  +++D  +  +      
Sbjct: 1722 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1781

Query: 313  SRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADM 366
            + + S IYF+ ++L    +  ++++A+++ + +   KE  EE A  E +L+ +M
Sbjct: 1782 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE-AELEAELELEM 1834



 Score = 86.3 bits (212), Expect = 6e-17
 Identities = 72/256 (28%), Positives = 131/256 (51%), Gaps = 15/256 (5%)

Query: 96  PLSLWAGWVLECPLFKNFIIFLVFLNTIILMVEIELLE-STNTKLWPLKLT--LEVAAWF 152
           P S+ A W L C  F+  +    F   I++ + +  L         P +LT  LE++   
Sbjct: 722 PSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIV 781

Query: 153 ILLIFILEILLKWLSNFSV-FWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRI 211
              +F LE+LLK L      + K+ +N+FD V+ ++S    V  +VG  G    L +LR 
Sbjct: 782 FTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVIS----VWEIVGQQGGG--LSVLRT 835

Query: 212 CRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPR 271
            R++R LKL+     +Q  ++VL++ + ++    MLL++F +IF++ G+++F     S R
Sbjct: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASER 895

Query: 272 --QDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGS 329
               L     F  L  ++VTVF + T + W  +L   +     +  ++++YFI  +  G+
Sbjct: 896 DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVL---YNGMASTSSWAALYFIALMTFGN 952

Query: 330 IIFRSIIVAMMVTNFQ 345
            +  +++VA++V  FQ
Sbjct: 953 YVLFNLLVAILVEGFQ 968



 Score = 49.3 bits (116), Expect = 9e-06
 Identities = 32/123 (26%), Positives = 63/123 (51%), Gaps = 11/123 (8%)

Query: 152 FILLIFILEILLKWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVVLVGVTGQSVWL 206
           FI   F +E+++K ++   +F K       WN  DF + +  +L   + L     Q+V  
Sbjct: 123 FIFAFFAVEMVVKMVA-LGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDL-----QNVSF 176

Query: 207 QLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEY 266
             +R  RVLR L+ + +   ++I++ +L+  L  +  +L+L    F+IF + GV +++  
Sbjct: 177 SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236

Query: 267 TRS 269
            R+
Sbjct: 237 LRN 239



 Score = 37.0 bits (84), Expect = 0.045
 Identities = 17/82 (20%), Positives = 44/82 (53%), Gaps = 3/82 (3%)

Query: 280 FSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAM 339
           F ++  + + +F + TL+ W  ++   + V +    ++ IYFIL +++GS    ++ + +
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIM---YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVV 393

Query: 340 MVTNFQNIRKELNEEMARREVQ 361
           + T F   ++  ++ M  + V+
Sbjct: 394 IATQFSETKQRESQLMREQRVR 415


>gi|38505286 voltage-dependent calcium channel alpha 1G subunit
            isoform 10 [Homo sapiens]
          Length = 2266

 Score = 96.7 bits (239), Expect = 5e-20
 Identities = 66/313 (21%), Positives = 158/313 (50%), Gaps = 40/313 (12%)

Query: 109  LFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLK---- 164
            +F + ++ ++FLN I + +E   ++  + +    ++ L ++ +    +F+ E+ +K    
Sbjct: 1277 MFDHVVLVIIFLNCITIAMERPKIDPHSAE----RIFLTLSNYIFTAVFLAEMTVKVVAL 1332

Query: 165  -WLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV--WLQLLRICRVLRSLKLL 221
             W      + +S+WNV D ++ ++S++  +V +V  +G  +   L++LR+ R LR L+++
Sbjct: 1333 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1392

Query: 222  AQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------------------ 263
            ++ + +++++  L+ +LK +  ++++   FF IF + GV +F                  
Sbjct: 1393 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNK 1452

Query: 264  SEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRI-------F 316
            S+   +  + + +   F +L  +L+++F+L + D W  ++ D      V +        +
Sbjct: 1453 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1512

Query: 317  SSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADMFKRQIIQRRK 376
              +YFI +LL+ +    ++ V ++V NF   R+   EE ARR  + +     R++ ++R+
Sbjct: 1513 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL----RRLEKKRR 1568

Query: 377  NMSHEALTSSHSK 389
                +   S +S+
Sbjct: 1569 KAQCKPYYSDYSR 1581



 Score = 92.8 bits (229), Expect = 7e-19
 Identities = 58/234 (24%), Positives = 123/234 (52%), Gaps = 14/234 (5%)

Query: 146  LEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSL----LPEVVVLVGVT 200
            L++  +   +IF+LE + K ++  F  F++  WN  D  + +LS+    L E+ V   + 
Sbjct: 1625 LKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLP 1684

Query: 201  GQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGV 260
                 ++++R+ R+ R LKLL     ++ ++  +++AL  +  L +L ++ F+IFA  GV
Sbjct: 1685 INPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGV 1744

Query: 261  YVFSEY---TRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPE-----V 312
             +F +       P + L  H  F +   + +T+F + T D+W  +++D  +  +      
Sbjct: 1745 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1804

Query: 313  SRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADM 366
            + + S IYF+ ++L    +  ++++A+++ + +   KE  EE A  E +L+ +M
Sbjct: 1805 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE-AELEAELELEM 1857



 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 76/270 (28%), Positives = 138/270 (51%), Gaps = 21/270 (7%)

Query: 96  PLSLWAGWVLECPLFKNFIIFLVFLNTIILMVEIELLE-STNTKLWPLKLT--LEVAAWF 152
           P S+ A W L C  F+  +    F   I++ + +  L         P +LT  LE++   
Sbjct: 722 PSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIV 781

Query: 153 ILLIFILEILLKWLSNFSV-FWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRI 211
              +F LE+LLK L      + K+ +N+FD V+ ++S    V  +VG  G    L +LR 
Sbjct: 782 FTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVIS----VWEIVGQQGGG--LSVLRT 835

Query: 212 CRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPR 271
            R++R LKL+     +Q  ++VL++ + ++    MLL++F +IF++ G+++F     S R
Sbjct: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASER 895

Query: 272 --QDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGS 329
               L     F  L  ++VTVF + T + W  +L   +     +  ++++YFI  +  G+
Sbjct: 896 DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVL---YNGMASTSSWAALYFIALMTFGN 952

Query: 330 IIFRSIIVAMMVTNFQNIRKELNEEMARRE 359
            +  +++VA++V  FQ       EE+++RE
Sbjct: 953 YVLFNLLVAILVEGFQ------AEEISKRE 976



 Score = 49.3 bits (116), Expect = 9e-06
 Identities = 32/123 (26%), Positives = 63/123 (51%), Gaps = 11/123 (8%)

Query: 152 FILLIFILEILLKWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVVLVGVTGQSVWL 206
           FI   F +E+++K ++   +F K       WN  DF + +  +L   + L     Q+V  
Sbjct: 123 FIFAFFAVEMVVKMVA-LGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDL-----QNVSF 176

Query: 207 QLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEY 266
             +R  RVLR L+ + +   ++I++ +L+  L  +  +L+L    F+IF + GV +++  
Sbjct: 177 SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236

Query: 267 TRS 269
            R+
Sbjct: 237 LRN 239



 Score = 37.0 bits (84), Expect = 0.045
 Identities = 17/82 (20%), Positives = 44/82 (53%), Gaps = 3/82 (3%)

Query: 280 FSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAM 339
           F ++  + + +F + TL+ W  ++   + V +    ++ IYFIL +++GS    ++ + +
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIM---YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVV 393

Query: 340 MVTNFQNIRKELNEEMARREVQ 361
           + T F   ++  ++ M  + V+
Sbjct: 394 IATQFSETKQRESQLMREQRVR 415


>gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H
            subunit isoform b [Homo sapiens]
          Length = 2347

 Score = 95.5 bits (236), Expect = 1e-19
 Identities = 67/272 (24%), Positives = 136/272 (50%), Gaps = 27/272 (9%)

Query: 113  FIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWLS-NFSV 171
            FI F++ +N I + +E      +      L   L+   +   ++F+ E  LK ++  F  
Sbjct: 1616 FITFIICVNVITMSMEHYNQPKS------LDEALKYCNYVFTIVFVFEAALKLVAFGFRR 1669

Query: 172  FWKSAWNVFDFVVTMLSL----LPEVVVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQI 227
            F+K  WN  D  + +LSL    L E+ +   +      ++++R+ R+ R LKLL     +
Sbjct: 1670 FFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGM 1729

Query: 228  QIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRS---PRQDLEYHVFFSDLP 284
            + ++  +V+AL  +  L +L ++ F+I+A  GV +F     S   P + L  H  FS+  
Sbjct: 1730 RALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFG 1789

Query: 285  NSLVTVFILFTLDHWYALLQDVWKVPEVSR----------IFSSIYFILWLLLGSIIFRS 334
             + +T+F + T D+W  +++D  +  E SR            S +YF+ ++L+   +  +
Sbjct: 1790 MAFLTLFRVSTGDNWNGIMKDTLR--ECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVN 1847

Query: 335  IIVAMMVTNFQNIRKELNEEMARREVQLKADM 366
            ++VA+++ + +   KE  E+ A  + +++ +M
Sbjct: 1848 VVVAVLMKHLEESNKEARED-AELDAEIELEM 1878



 Score = 93.6 bits (231), Expect = 4e-19
 Identities = 72/306 (23%), Positives = 153/306 (50%), Gaps = 38/306 (12%)

Query: 104  VLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILL 163
            V+   +F + ++  +FLN + + +E   ++  +T+    ++ L V+ +    IF+ E+++
Sbjct: 1290 VITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTE----RVFLSVSNYIFTAIFVAEMMV 1345

Query: 164  K-----WLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVW--LQLLRICRVLR 216
            K      LS    + +S+WN+ D ++ ++SL+  VV +    G  +   L++LR+ R LR
Sbjct: 1346 KVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLR 1405

Query: 217  SLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEY---------- 266
             L+++++   +++++  L+ +L+ +  ++++   FF IF + GV +F             
Sbjct: 1406 PLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTR 1465

Query: 267  ---TRSPRQDLEYHVF-----FSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRI--- 315
               T++  +   Y        F +L  +L+++F+L + D W  ++ D      V +    
Sbjct: 1466 NISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQ 1525

Query: 316  ----FSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARR--EVQLKADMFKR 369
                +  +YFI +LL+ S    ++ V ++V NF   R+    E ARR  E +L+    +R
Sbjct: 1526 NHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLERRR 1585

Query: 370  QIIQRR 375
            +  QRR
Sbjct: 1586 RKAQRR 1591



 Score = 76.6 bits (187), Expect = 5e-14
 Identities = 67/301 (22%), Positives = 145/301 (48%), Gaps = 27/301 (8%)

Query: 104  VLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILL 163
            +++   F   I+  + +NT+ + VE        T        LE++      +F LE+LL
Sbjct: 789  IVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTN------ALEISNIVFTSMFALEMLL 842

Query: 164  KWLSNFSV-FWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVW-LQLLRICRVLRSLKLL 221
            K L+   + + ++ +N+FD ++ ++S+         + GQ+   L +LR  R+LR LKL+
Sbjct: 843  KLLACGPLGYIRNPYNIFDGIIVVISVWE-------IVGQADGGLSVLRTFRLLRVLKLV 895

Query: 222  AQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFS---EYTRSPRQDLEYHV 278
                 ++  ++VLV+ + ++     LL++F +IF++ G+++F             +    
Sbjct: 896  RFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRK 955

Query: 279  FFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVA 338
             F  L  ++VTVF + T + W  +L   +     +  ++++YF+  +  G+ +  +++VA
Sbjct: 956  NFDSLLWAIVTVFQILTQEDWNVVL---YNGMASTSSWAALYFVALMTFGNYVLFNLLVA 1012

Query: 339  MMVTNFQ----NIRKELNEEMARREVQLKADMFKRQIIQRRKNMSHEALTSSHSKIEDRG 394
            ++V  FQ      R + +E+  +  V  + D  K + +Q  +        + +  +E RG
Sbjct: 1013 ILVEGFQAEGDANRSDTDED--KTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLEGRG 1070

Query: 395  A 395
            +
Sbjct: 1071 S 1071



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 31/128 (24%), Positives = 63/128 (49%), Gaps = 9/128 (7%)

Query: 146 LEVAAWFILLIFILEILLKWLS----NFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTG 201
           LE    FI   F +E+++K ++        +    WN  DF + +  ++        + G
Sbjct: 136 LEAFDAFIFAFFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMME-----YSLDG 190

Query: 202 QSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVY 261
            +V L  +R  RVLR L+ + +   ++I++ +L+  L  +  +L+L    F+IF + GV 
Sbjct: 191 HNVSLSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQ 250

Query: 262 VFSEYTRS 269
           +++   R+
Sbjct: 251 LWAGLLRN 258



 Score = 38.9 bits (89), Expect = 0.012
 Identities = 25/110 (22%), Positives = 56/110 (50%), Gaps = 18/110 (16%)

Query: 280 FSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAM 339
           F ++  + + +F + TL+ W  ++   + V +    ++ IYFIL +++GS    ++ + +
Sbjct: 361 FDNIGYAWIAIFQVITLEGWVDIM---YYVMDAHSFYNFIYFILLIIVGSFFMINLCLVV 417

Query: 340 MVTNFQNIRKELNEEMARREVQLKADMFKRQIIQRRKNMSHEALTSSHSK 389
           + T F         E  +RE QL  +       QR +++S+++  +S S+
Sbjct: 418 IATQF--------SETKQRESQLMRE-------QRARHLSNDSTLASFSE 452


>gi|53832009 calcium channel, voltage-dependent, T type, alpha 1H
            subunit isoform a [Homo sapiens]
          Length = 2353

 Score = 95.5 bits (236), Expect = 1e-19
 Identities = 67/272 (24%), Positives = 136/272 (50%), Gaps = 27/272 (9%)

Query: 113  FIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWLS-NFSV 171
            FI F++ +N I + +E      +      L   L+   +   ++F+ E  LK ++  F  
Sbjct: 1622 FITFIICVNVITMSMEHYNQPKS------LDEALKYCNYVFTIVFVFEAALKLVAFGFRR 1675

Query: 172  FWKSAWNVFDFVVTMLSL----LPEVVVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQI 227
            F+K  WN  D  + +LSL    L E+ +   +      ++++R+ R+ R LKLL     +
Sbjct: 1676 FFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGM 1735

Query: 228  QIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRS---PRQDLEYHVFFSDLP 284
            + ++  +V+AL  +  L +L ++ F+I+A  GV +F     S   P + L  H  FS+  
Sbjct: 1736 RALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFG 1795

Query: 285  NSLVTVFILFTLDHWYALLQDVWKVPEVSR----------IFSSIYFILWLLLGSIIFRS 334
             + +T+F + T D+W  +++D  +  E SR            S +YF+ ++L+   +  +
Sbjct: 1796 MAFLTLFRVSTGDNWNGIMKDTLR--ECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVN 1853

Query: 335  IIVAMMVTNFQNIRKELNEEMARREVQLKADM 366
            ++VA+++ + +   KE  E+ A  + +++ +M
Sbjct: 1854 VVVAVLMKHLEESNKEARED-AELDAEIELEM 1884



 Score = 92.4 bits (228), Expect = 9e-19
 Identities = 67/299 (22%), Positives = 148/299 (49%), Gaps = 36/299 (12%)

Query: 104  VLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILL 163
            V+   +F + ++  +FLN + + +E   ++  +T+    ++ L V+ +    IF+ E+++
Sbjct: 1290 VITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTE----RVFLSVSNYIFTAIFVAEMMV 1345

Query: 164  K-----WLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVW--LQLLRICRVLR 216
            K      LS    + +S+WN+ D ++ ++SL+  VV +    G  +   L++LR+ R LR
Sbjct: 1346 KVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLR 1405

Query: 217  SLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEY---------- 266
             L+++++   +++++  L+ +L+ +  ++++   FF IF + GV +F             
Sbjct: 1406 PLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTR 1465

Query: 267  ---TRSPRQDLEYHVF-----FSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRI--- 315
               T++  +   Y        F +L  +L+++F+L + D W  ++ D      V +    
Sbjct: 1466 NISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQ 1525

Query: 316  ----FSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADMFKRQ 370
                +  +YFI +LL+ S    ++ V ++V NF   R+    E ARR  + +    +R+
Sbjct: 1526 NHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLERR 1584



 Score = 76.6 bits (187), Expect = 5e-14
 Identities = 67/301 (22%), Positives = 145/301 (48%), Gaps = 27/301 (8%)

Query: 104  VLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILL 163
            +++   F   I+  + +NT+ + VE        T        LE++      +F LE+LL
Sbjct: 789  IVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTN------ALEISNIVFTSMFALEMLL 842

Query: 164  KWLSNFSV-FWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVW-LQLLRICRVLRSLKLL 221
            K L+   + + ++ +N+FD ++ ++S+         + GQ+   L +LR  R+LR LKL+
Sbjct: 843  KLLACGPLGYIRNPYNIFDGIIVVISVWE-------IVGQADGGLSVLRTFRLLRVLKLV 895

Query: 222  AQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFS---EYTRSPRQDLEYHV 278
                 ++  ++VLV+ + ++     LL++F +IF++ G+++F             +    
Sbjct: 896  RFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRK 955

Query: 279  FFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVA 338
             F  L  ++VTVF + T + W  +L   +     +  ++++YF+  +  G+ +  +++VA
Sbjct: 956  NFDSLLWAIVTVFQILTQEDWNVVL---YNGMASTSSWAALYFVALMTFGNYVLFNLLVA 1012

Query: 339  MMVTNFQ----NIRKELNEEMARREVQLKADMFKRQIIQRRKNMSHEALTSSHSKIEDRG 394
            ++V  FQ      R + +E+  +  V  + D  K + +Q  +        + +  +E RG
Sbjct: 1013 ILVEGFQAEGDANRSDTDED--KTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLEGRG 1070

Query: 395  A 395
            +
Sbjct: 1071 S 1071



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 31/128 (24%), Positives = 63/128 (49%), Gaps = 9/128 (7%)

Query: 146 LEVAAWFILLIFILEILLKWLS----NFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTG 201
           LE    FI   F +E+++K ++        +    WN  DF + +  ++        + G
Sbjct: 136 LEAFDAFIFAFFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMME-----YSLDG 190

Query: 202 QSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVY 261
            +V L  +R  RVLR L+ + +   ++I++ +L+  L  +  +L+L    F+IF + GV 
Sbjct: 191 HNVSLSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQ 250

Query: 262 VFSEYTRS 269
           +++   R+
Sbjct: 251 LWAGLLRN 258



 Score = 38.9 bits (89), Expect = 0.012
 Identities = 25/110 (22%), Positives = 56/110 (50%), Gaps = 18/110 (16%)

Query: 280 FSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAM 339
           F ++  + + +F + TL+ W  ++   + V +    ++ IYFIL +++GS    ++ + +
Sbjct: 361 FDNIGYAWIAIFQVITLEGWVDIM---YYVMDAHSFYNFIYFILLIIVGSFFMINLCLVV 417

Query: 340 MVTNFQNIRKELNEEMARREVQLKADMFKRQIIQRRKNMSHEALTSSHSK 389
           + T F         E  +RE QL  +       QR +++S+++  +S S+
Sbjct: 418 IATQF--------SETKQRESQLMRE-------QRARHLSNDSTLASFSE 452


>gi|53832005 calcium channel, voltage-dependent, R type, alpha 1E
           subunit [Homo sapiens]
          Length = 2270

 Score = 95.1 bits (235), Expect = 1e-19
 Identities = 89/336 (26%), Positives = 163/336 (48%), Gaps = 33/336 (9%)

Query: 64  LVRFSIKPQRIEQIS---HAQRLLSRLHVRCSQRPPLSLWAGWVLECPLFKNFIIFLVFL 120
           L R SIK  +++ +S   H +RLL R+ +R   +  +  W             ++ LV L
Sbjct: 442 LARASIKSAKVDGVSYFRHKERLL-RISIRHMVKSQVFYW------------IVLSLVAL 488

Query: 121 NTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNV 179
           NT  + +        N   W   L L  A +  L +F+LE+ LK       +++ S++N 
Sbjct: 489 NTACVAIVHH-----NQPQWLTHL-LYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFNC 542

Query: 180 FDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALK 239
           FDF VT+ S+  EVV  +   G S  + +LR  R+LR  K+   +  ++ +++ L+ ++K
Sbjct: 543 FDFGVTVGSIF-EVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSMK 601

Query: 240 SMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHW 299
           S+  LL LL +F  +FA+ G+ +F    R    D      F   P +++TVF + T + W
Sbjct: 602 SIISLLFLLFLFIVVFALLGMQLFG--GRFNFNDGTPSANFDTFPAAIMTVFQILTGEDW 659

Query: 300 YALLQDVWKVP--EVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMAR 357
             ++ +  +      S ++S+IYFI+  L G+    ++ +A+ V N  N      +E+ +
Sbjct: 660 NEVMYNGIRSQGGVSSGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANA-----QELTK 714

Query: 358 REVQLKADMFKRQIIQRRKNMSHEALTSSHSKIEDR 393
            E + +    ++  +Q+ K +S  +  +  S   DR
Sbjct: 715 DEQEEEEAFNQKHALQKAKEVSPMSAPNMPSIERDR 750



 Score = 85.9 bits (211), Expect = 8e-17
 Identities = 61/264 (23%), Positives = 132/264 (50%), Gaps = 30/264 (11%)

Query: 108  PLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWLS 167
            P F+  I+ ++ LNT++LM++      T       +L L+       ++F LE +LK ++
Sbjct: 1478 PSFEYTIMAMIALNTVVLMMKYYSAPCT------YELALKYLNIAFTMVFSLECVLKVIA 1531

Query: 168  -NFSVFWKSAWNVFDFVVTMLSLLPEVVV----LVGVTGQSVWLQLLRICRVLRSLKLLA 222
              F  +++  WN+FDF+ T++  + E+++    LV  +G +  +  L++ R  R +KLL 
Sbjct: 1532 FGFLNYFRDTWNIFDFI-TVIGSITEIILTDSKLVNTSGFN--MSFLKLFRAARLIKLLR 1588

Query: 223  QFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHVFFSD 282
            Q   I+I++   V++ K++ ++ +L+ + F+I+A+ G+ VF          +  H  F  
Sbjct: 1589 QGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLDEESHINRHNNFRS 1648

Query: 283  LPNSLVTVFILFTLDHWYAL----LQDVWKVPEVSRI------------FSSIYFILWLL 326
               SL+ +F   T + W  +    L +    P+ +               + +YF+ ++ 
Sbjct: 1649 FFGSLMLLFRSATGEAWQEIMLSCLGEKGCEPDTTAPSGQNENERCGTDLAYVYFVSFIF 1708

Query: 327  LGSIIFRSIIVAMMVTNFQNIRKE 350
              S +  ++ VA+++ NF+ + ++
Sbjct: 1709 FCSFLMLNLFVAVIMDNFEYLTRD 1732



 Score = 67.4 bits (163), Expect = 3e-11
 Identities = 66/311 (21%), Positives = 133/311 (42%), Gaps = 55/311 (17%)

Query: 100 WAGWVLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFIL 159
           +A  +++ P F+  I+  +  N I+L +E  L E   T   P+   LE    + + IF  
Sbjct: 81  YAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKT---PMSRRLEKTEPYFIGIFCF 137

Query: 160 EILLKWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRICRV 214
           E  +K ++   +F K +     WNV DF+V +  +L             V L+ LR  RV
Sbjct: 138 EAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNT---HVDLRTLRAVRV 194

Query: 215 LRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTR------ 268
           LR LKL++    +QI++  +++A+  +  + +LL     +FA+ G+  +S          
Sbjct: 195 LRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMN 254

Query: 269 -----------------------------SPRQDLEYHVFFSDLPNSLVTVFILFTLDHW 299
                                         P   +     F ++  +++TVF   T++ W
Sbjct: 255 NSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQ---FDNILFAVLTVFQCITMEGW 311

Query: 300 YALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMA--- 356
             +L +      +   ++ +YFI  +++GS    ++++ ++   F   R+ +    A   
Sbjct: 312 TTVLYNT--NDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERERVENRRAFMK 369

Query: 357 -RREVQLKADM 366
            RR+ Q++ ++
Sbjct: 370 LRRQQQIEREL 380



 Score = 65.9 bits (159), Expect = 9e-11
 Identities = 61/301 (20%), Positives = 135/301 (44%), Gaps = 47/301 (15%)

Query: 96   PLSLWAGWVLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILL 155
            P+     +++    F+  I+ ++  ++I L  E  +L ++          L    +    
Sbjct: 1141 PIRRACHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNK-----VLRYFDYVFTG 1195

Query: 156  IFILEILLKWLSNFSV-----FWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQS---VWLQ 207
            +F  E+++K +    +     +++  WN+ DFVV + +L+   +     T +      ++
Sbjct: 1196 VFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIK 1255

Query: 208  LLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSE-- 265
             LR+ RVLR LK + +  +++ +   +V +LK++  +L++  +F +IFAV  V +F    
Sbjct: 1256 SLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKF 1315

Query: 266  -YTRSPRQDLE------------------------YHVFFSDLPNSLVTVFILFTLDHWY 300
             Y     +D E                        +   + ++  +L+T+F + T + W 
Sbjct: 1316 FYCTDSSKDTEKECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWP 1375

Query: 301  ALLQDVWKVPE-------VSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNE 353
             +LQ    V E        +R+  SI+++++ ++    F +I VA+++  FQ    ++ E
Sbjct: 1376 QVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMME 1435

Query: 354  E 354
            E
Sbjct: 1436 E 1436


>gi|193788732 calcium channel, voltage-dependent, L type, alpha 1C
           subunit isoform 5 [Homo sapiens]
          Length = 2166

 Score = 94.0 bits (232), Expect = 3e-19
 Identities = 86/344 (25%), Positives = 154/344 (44%), Gaps = 32/344 (9%)

Query: 85  SRLHVRCSQRPPLSLWAGWVLECP----------LFKNFIIFLVFLNTIILMVEIELLES 134
           +RL  R S+      W  W   C           +F   +IFLVFLNT+ +  E      
Sbjct: 491 ARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASE-----H 545

Query: 135 TNTKLWPLKLTLEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSLLPEV 193
            N   W L    + A   +L +F  E+LLK  S     ++ S +N FD  V    +L  +
Sbjct: 546 YNQPNW-LTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETI 604

Query: 194 VVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFY 253
           +V   +    + + +LR  R+LR  K+   +  +  ++  L+ +++S+  LL+LL +F  
Sbjct: 605 LVETKIMSP-LGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFII 663

Query: 254 IFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQD---VWKVP 310
           IF++ G+ +F               F  + P SL+TVF + T + W +++ D    +  P
Sbjct: 664 IFSLLGMQLFGGKFNFDEMQTRRSTF-DNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGP 722

Query: 311 EVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTN------FQNIRKELNEEMARREVQLKA 364
               +   IYFI+  + G+ I  ++ +A+ V N        + +KE  EE  R+++   A
Sbjct: 723 SFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTA 782

Query: 365 DMFKRQIIQRRKNMSHEALTSSHSKIEDRGASQQRESLDLSEVS 408
              K+Q +  +  +      S   KIE +  +   ES   ++++
Sbjct: 783 SPEKKQELVEKPAVGE----SKEEKIELKSITADGESPPATKIN 822



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 60/300 (20%), Positives = 136/300 (45%), Gaps = 52/300 (17%)

Query: 103  WVLECPLFKNFIIFLVFLNTIILMVE-----------IELLESTNTKLWPLKLTLEVAAW 151
            +V+    F+  +  L+ LNTI L ++           + +L    T L+ +++ L++ A+
Sbjct: 1214 YVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAF 1273

Query: 152  ------------FILLIFILEILLKWLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGV 199
                        F  LI I  I+   LS  + ++  AWN FD ++ + S++   +  V  
Sbjct: 1274 KPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNP 1333

Query: 200  TGQS-------------VWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLM 246
               +             + +   R+ RV+R +KLL++   I+ ++   +++ +++ ++ +
Sbjct: 1334 AEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVAL 1393

Query: 247  LLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHW----YAL 302
            L+++ F+I+AV G+ VF +   +   ++  +  F   P +++ +F   T + W     A 
Sbjct: 1394 LIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLAC 1453

Query: 303  LQDVWKVPE------------VSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKE 350
            +      PE                F+  YFI + +L + +  ++ VA+++ NF  + ++
Sbjct: 1454 MPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRD 1513



 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 69/320 (21%), Positives = 138/320 (43%), Gaps = 62/320 (19%)

Query: 104 VLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILL 163
           ++E   F+  I+  +F N + L + I   E  +         LE   +  L+IF +E  L
Sbjct: 120 IVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNAT---NSNLERVEYLFLIIFTVEAFL 176

Query: 164 KWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVV---------LVGVTGQSVWLQLL 209
           K ++   +F  +A     WN+ DF++ ++ L   ++           +G  G    ++ L
Sbjct: 177 KVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKAL 236

Query: 210 RICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------ 263
           R  RVLR L+L++    +Q+++  +++A+  +  + +L+L    I+A+ G+ +F      
Sbjct: 237 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296

Query: 264 ------------SEYTRSP--------RQ-----------DLEYH--VFFSDLPNSLVTV 290
                       +E   SP        RQ           D   H    F +   +++TV
Sbjct: 297 TCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTV 356

Query: 291 FILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKE 350
           F   T++ W  +L   W    V R +  IYF+  +++GS    ++++ ++   F   R++
Sbjct: 357 FQCITMEGWTDVL--YWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREK 414

Query: 351 LNE----EMARREVQLKADM 366
                  +  R + QL+ D+
Sbjct: 415 AKARGDFQKLREKQQLEEDL 434



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 57/283 (20%), Positives = 125/283 (44%), Gaps = 59/283 (20%)

Query: 109  LFKNFIIFLVFLNTIILMVE--IELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWL 166
            +F N I+F + L++I L  E  ++     N  L+   +           IF +EI LK  
Sbjct: 901  IFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTT-------IFTIEIALKMT 953

Query: 167  S-----NFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV-WLQLLRICRVLRSLKL 220
            +     +   F ++ +N+ D +V  +SL+       G+   ++  +++LR+ RVLR L+ 
Sbjct: 954  AYGAFLHKGSFCRNYFNILDLLVVSVSLIS-----FGIQSSAINVVKILRVLRVLRPLRA 1008

Query: 221  LAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSE--YTRS--------- 269
            + + + ++ ++  +  A++++  ++++  +  ++FA  GV +F    YT S         
Sbjct: 1009 INRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAE 1068

Query: 270  -------------------PRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALL------- 303
                               PR        F ++  +++ +F + T + W  LL       
Sbjct: 1069 CKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSH 1128

Query: 304  -QDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQ 345
             +D   +    R+  SI+FI+++++ +    +I V  ++  FQ
Sbjct: 1129 TEDKGPIYNY-RVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQ 1170


>gi|193788730 calcium channel, voltage-dependent, L type, alpha 1C
           subunit isoform 4 [Homo sapiens]
          Length = 2173

 Score = 94.0 bits (232), Expect = 3e-19
 Identities = 86/344 (25%), Positives = 154/344 (44%), Gaps = 32/344 (9%)

Query: 85  SRLHVRCSQRPPLSLWAGWVLECP----------LFKNFIIFLVFLNTIILMVEIELLES 134
           +RL  R S+      W  W   C           +F   +IFLVFLNT+ +  E      
Sbjct: 491 ARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASE-----H 545

Query: 135 TNTKLWPLKLTLEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSLLPEV 193
            N   W L    + A   +L +F  E+LLK  S     ++ S +N FD  V    +L  +
Sbjct: 546 YNQPNW-LTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETI 604

Query: 194 VVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFY 253
           +V   +    + + +LR  R+LR  K+   +  +  ++  L+ +++S+  LL+LL +F  
Sbjct: 605 LVETKIMSP-LGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFII 663

Query: 254 IFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQD---VWKVP 310
           IF++ G+ +F               F  + P SL+TVF + T + W +++ D    +  P
Sbjct: 664 IFSLLGMQLFGGKFNFDEMQTRRSTF-DNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGP 722

Query: 311 EVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTN------FQNIRKELNEEMARREVQLKA 364
               +   IYFI+  + G+ I  ++ +A+ V N        + +KE  EE  R+++   A
Sbjct: 723 SFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTA 782

Query: 365 DMFKRQIIQRRKNMSHEALTSSHSKIEDRGASQQRESLDLSEVS 408
              K+Q +  +  +      S   KIE +  +   ES   ++++
Sbjct: 783 SPEKKQELVEKPAVGE----SKEEKIELKSITADGESPPATKIN 822



 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 69/320 (21%), Positives = 138/320 (43%), Gaps = 62/320 (19%)

Query: 104 VLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILL 163
           ++E   F+  I+  +F N + L + I   E  +         LE   +  L+IF +E  L
Sbjct: 120 IVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNAT---NSNLERVEYLFLIIFTVEAFL 176

Query: 164 KWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVV---------LVGVTGQSVWLQLL 209
           K ++   +F  +A     WN+ DF++ ++ L   ++           +G  G    ++ L
Sbjct: 177 KVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKAL 236

Query: 210 RICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------ 263
           R  RVLR L+L++    +Q+++  +++A+  +  + +L+L    I+A+ G+ +F      
Sbjct: 237 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296

Query: 264 ------------SEYTRSP--------RQ-----------DLEYH--VFFSDLPNSLVTV 290
                       +E   SP        RQ           D   H    F +   +++TV
Sbjct: 297 TCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTV 356

Query: 291 FILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKE 350
           F   T++ W  +L   W    V R +  IYF+  +++GS    ++++ ++   F   R++
Sbjct: 357 FQCITMEGWTDVL--YWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREK 414

Query: 351 LNE----EMARREVQLKADM 366
                  +  R + QL+ D+
Sbjct: 415 AKARGDFQKLREKQQLEEDL 434



 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 53/278 (19%), Positives = 128/278 (46%), Gaps = 36/278 (12%)

Query: 103  WVLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEIL 162
            +V+    F+  +  L+ LNTI L ++         +    K+ + +       +F +E++
Sbjct: 1214 YVVNSTYFEYLMFVLILLNTICLAMQ------HYGQSCLFKIAMNILNMLFTGLFTVEMI 1267

Query: 163  LKWLS-NFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQS-------------VWLQL 208
            LK ++     ++  AWN FD ++ + S++   +  V     +             + +  
Sbjct: 1268 LKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITF 1327

Query: 209  LRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTR 268
             R+ RV+R +KLL++   I+ ++   +++ +++ ++ +L+++ F+I+AV G+ VF +   
Sbjct: 1328 FRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIAL 1387

Query: 269  SPRQDLEYHVFFSDLPNSLVTVFILFTLDHW----YALLQDVWKVPE------------V 312
            +   ++  +  F   P +++ +F   T + W     A +      PE             
Sbjct: 1388 NDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPC 1447

Query: 313  SRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKE 350
               F+  YFI + +L + +  ++ VA+++ NF  + ++
Sbjct: 1448 GSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRD 1485



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 59/281 (20%), Positives = 129/281 (45%), Gaps = 55/281 (19%)

Query: 109  LFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWLS- 167
            +F N I+F + L++I L  E + ++ T+ +       L  A +    IF LEI+LK  + 
Sbjct: 901  IFTNLILFFILLSSISLAAE-DPVQHTSFR----NHILGNADYVFTSIFTLEIILKMTAY 955

Query: 168  ----NFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV-WLQLLRICRVLRSLKLLA 222
                +   F ++ +N+ D +V  +SL+       G+   ++  +++LR+ RVLR L+ + 
Sbjct: 956  GAFLHKGSFCRNYFNILDLLVVSVSLIS-----FGIQSSAINVVKILRVLRVLRPLRAIN 1010

Query: 223  QFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSE--YTRS----------- 269
            + + ++ ++  +  A++++  ++++  +  ++FA  GV +F    YT S           
Sbjct: 1011 RAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECK 1070

Query: 270  -----------------PRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALL--------Q 304
                             PR        F ++  +++ +F + T + W  LL        +
Sbjct: 1071 GNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTE 1130

Query: 305  DVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQ 345
            D   +    R+  SI+FI+++++ +    +I V  ++  FQ
Sbjct: 1131 DKGPIYNY-RVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQ 1170


>gi|193788728 calcium channel, voltage-dependent, L type, alpha 1C
           subunit isoform 3 [Homo sapiens]
          Length = 2179

 Score = 94.0 bits (232), Expect = 3e-19
 Identities = 86/344 (25%), Positives = 154/344 (44%), Gaps = 32/344 (9%)

Query: 85  SRLHVRCSQRPPLSLWAGWVLECP----------LFKNFIIFLVFLNTIILMVEIELLES 134
           +RL  R S+      W  W   C           +F   +IFLVFLNT+ +  E      
Sbjct: 491 ARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASE-----H 545

Query: 135 TNTKLWPLKLTLEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSLLPEV 193
            N   W L    + A   +L +F  E+LLK  S     ++ S +N FD  V    +L  +
Sbjct: 546 YNQPNW-LTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETI 604

Query: 194 VVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFY 253
           +V   +    + + +LR  R+LR  K+   +  +  ++  L+ +++S+  LL+LL +F  
Sbjct: 605 LVETKIMSP-LGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFII 663

Query: 254 IFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQD---VWKVP 310
           IF++ G+ +F               F  + P SL+TVF + T + W +++ D    +  P
Sbjct: 664 IFSLLGMQLFGGKFNFDEMQTRRSTF-DNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGP 722

Query: 311 EVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTN------FQNIRKELNEEMARREVQLKA 364
               +   IYFI+  + G+ I  ++ +A+ V N        + +KE  EE  R+++   A
Sbjct: 723 SFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTA 782

Query: 365 DMFKRQIIQRRKNMSHEALTSSHSKIEDRGASQQRESLDLSEVS 408
              K+Q +  +  +      S   KIE +  +   ES   ++++
Sbjct: 783 SPEKKQELVEKPAVGE----SKEEKIELKSITADGESPPATKIN 822



 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 69/320 (21%), Positives = 138/320 (43%), Gaps = 62/320 (19%)

Query: 104 VLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILL 163
           ++E   F+  I+  +F N + L + I   E  +         LE   +  L+IF +E  L
Sbjct: 120 IVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNAT---NSNLERVEYLFLIIFTVEAFL 176

Query: 164 KWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVV---------LVGVTGQSVWLQLL 209
           K ++   +F  +A     WN+ DF++ ++ L   ++           +G  G    ++ L
Sbjct: 177 KVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKAL 236

Query: 210 RICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------ 263
           R  RVLR L+L++    +Q+++  +++A+  +  + +L+L    I+A+ G+ +F      
Sbjct: 237 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296

Query: 264 ------------SEYTRSP--------RQ-----------DLEYH--VFFSDLPNSLVTV 290
                       +E   SP        RQ           D   H    F +   +++TV
Sbjct: 297 TCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTV 356

Query: 291 FILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKE 350
           F   T++ W  +L   W    V R +  IYF+  +++GS    ++++ ++   F   R++
Sbjct: 357 FQCITMEGWTDVL--YWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREK 414

Query: 351 LNE----EMARREVQLKADM 366
                  +  R + QL+ D+
Sbjct: 415 AKARGDFQKLREKQQLEEDL 434



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 55/300 (18%), Positives = 129/300 (43%), Gaps = 58/300 (19%)

Query: 103  WVLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEIL 162
            +V+    F+  +  L+ LNTI L ++         +    K+ + +       +F +E++
Sbjct: 1214 YVVNSTYFEYLMFVLILLNTICLAMQ------HYGQSCLFKIAMNILNMLFTGLFTVEMI 1267

Query: 163  LKWLS-NFSVFWKSAWNVFDFVVTMLSLL-------------------------PEVVVL 196
            LK ++     ++  AWN FD ++ + S++                         P + VL
Sbjct: 1268 LKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMGPSCSHPPLAVL 1327

Query: 197  VGVT----------GQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLM 246
                             + +   R+ RV+R +KLL++   I+ ++   +++ +++ ++ +
Sbjct: 1328 TAPPVADGFQNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVAL 1387

Query: 247  LLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHW----YAL 302
            L+++ F+I+AV G+ VF +   +   ++  +  F   P +++ +F   T + W     A 
Sbjct: 1388 LIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLAC 1447

Query: 303  LQDVWKVPE------------VSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKE 350
            +      PE                F+  YFI + +L + +  ++ VA+++ NF  + ++
Sbjct: 1448 MPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRD 1507



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 57/283 (20%), Positives = 125/283 (44%), Gaps = 59/283 (20%)

Query: 109  LFKNFIIFLVFLNTIILMVE--IELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWL 166
            +F N I+F + L++I L  E  ++     N  L+   +           IF +EI LK  
Sbjct: 901  IFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTT-------IFTIEIALKMT 953

Query: 167  S-----NFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV-WLQLLRICRVLRSLKL 220
            +     +   F ++ +N+ D +V  +SL+       G+   ++  +++LR+ RVLR L+ 
Sbjct: 954  AYGAFLHKGSFCRNYFNILDLLVVSVSLIS-----FGIQSSAINVVKILRVLRVLRPLRA 1008

Query: 221  LAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSE--YTRS--------- 269
            + + + ++ ++  +  A++++  ++++  +  ++FA  GV +F    YT S         
Sbjct: 1009 INRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAE 1068

Query: 270  -------------------PRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALL------- 303
                               PR        F ++  +++ +F + T + W  LL       
Sbjct: 1069 CKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSH 1128

Query: 304  -QDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQ 345
             +D   +    R+  SI+FI+++++ +    +I V  ++  FQ
Sbjct: 1129 TEDKGPIYNY-RVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQ 1170


>gi|193788724 calcium channel, voltage-dependent, L type, alpha 1C
           subunit isoform 2 [Homo sapiens]
          Length = 2186

 Score = 94.0 bits (232), Expect = 3e-19
 Identities = 86/344 (25%), Positives = 154/344 (44%), Gaps = 32/344 (9%)

Query: 85  SRLHVRCSQRPPLSLWAGWVLECP----------LFKNFIIFLVFLNTIILMVEIELLES 134
           +RL  R S+      W  W   C           +F   +IFLVFLNT+ +  E      
Sbjct: 491 ARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASE-----H 545

Query: 135 TNTKLWPLKLTLEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSLLPEV 193
            N   W L    + A   +L +F  E+LLK  S     ++ S +N FD  V    +L  +
Sbjct: 546 YNQPNW-LTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETI 604

Query: 194 VVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFY 253
           +V   +    + + +LR  R+LR  K+   +  +  ++  L+ +++S+  LL+LL +F  
Sbjct: 605 LVETKIMSP-LGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFII 663

Query: 254 IFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQD---VWKVP 310
           IF++ G+ +F               F  + P SL+TVF + T + W +++ D    +  P
Sbjct: 664 IFSLLGMQLFGGKFNFDEMQTRRSTF-DNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGP 722

Query: 311 EVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTN------FQNIRKELNEEMARREVQLKA 364
               +   IYFI+  + G+ I  ++ +A+ V N        + +KE  EE  R+++   A
Sbjct: 723 SFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTA 782

Query: 365 DMFKRQIIQRRKNMSHEALTSSHSKIEDRGASQQRESLDLSEVS 408
              K+Q +  +  +      S   KIE +  +   ES   ++++
Sbjct: 783 SPEKKQELVEKPAVGE----SKEEKIELKSITADGESPPATKIN 822



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 60/300 (20%), Positives = 136/300 (45%), Gaps = 52/300 (17%)

Query: 103  WVLECPLFKNFIIFLVFLNTIILMVE-----------IELLESTNTKLWPLKLTLEVAAW 151
            +V+    F+  +  L+ LNTI L ++           + +L    T L+ +++ L++ A+
Sbjct: 1234 YVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAF 1293

Query: 152  ------------FILLIFILEILLKWLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGV 199
                        F  LI I  I+   LS  + ++  AWN FD ++ + S++   +  V  
Sbjct: 1294 KPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNP 1353

Query: 200  TGQS-------------VWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLM 246
               +             + +   R+ RV+R +KLL++   I+ ++   +++ +++ ++ +
Sbjct: 1354 AEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVAL 1413

Query: 247  LLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHW----YAL 302
            L+++ F+I+AV G+ VF +   +   ++  +  F   P +++ +F   T + W     A 
Sbjct: 1414 LIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLAC 1473

Query: 303  LQDVWKVPE------------VSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKE 350
            +      PE                F+  YFI + +L + +  ++ VA+++ NF  + ++
Sbjct: 1474 MPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRD 1533



 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 69/320 (21%), Positives = 138/320 (43%), Gaps = 62/320 (19%)

Query: 104 VLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILL 163
           ++E   F+  I+  +F N + L + I   E  +         LE   +  L+IF +E  L
Sbjct: 120 IVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNAT---NSNLERVEYLFLIIFTVEAFL 176

Query: 164 KWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVV---------LVGVTGQSVWLQLL 209
           K ++   +F  +A     WN+ DF++ ++ L   ++           +G  G    ++ L
Sbjct: 177 KVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKAL 236

Query: 210 RICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------ 263
           R  RVLR L+L++    +Q+++  +++A+  +  + +L+L    I+A+ G+ +F      
Sbjct: 237 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296

Query: 264 ------------SEYTRSP--------RQ-----------DLEYH--VFFSDLPNSLVTV 290
                       +E   SP        RQ           D   H    F +   +++TV
Sbjct: 297 TCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTV 356

Query: 291 FILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKE 350
           F   T++ W  +L   W    V R +  IYF+  +++GS    ++++ ++   F   R++
Sbjct: 357 FQCITMEGWTDVL--YWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREK 414

Query: 351 LNE----EMARREVQLKADM 366
                  +  R + QL+ D+
Sbjct: 415 AKARGDFQKLREKQQLEEDL 434



 Score = 55.8 bits (133), Expect = 9e-08
 Identities = 59/296 (19%), Positives = 133/296 (44%), Gaps = 65/296 (21%)

Query: 109  LFKNFIIFLVFLNTIILMVE------------IELLESTNTKLWPLKLTLEV---AAWFI 153
            +F N I+F + L++I L  E            +   +   T ++ +++ L++   A +  
Sbjct: 901  IFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKILGNADYVF 960

Query: 154  LLIFILEILLKWLS-----NFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV-WLQ 207
              IF LEI+LK  +     +   F ++ +N+ D +V  +SL+       G+   ++  ++
Sbjct: 961  TSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLIS-----FGIQSSAINVVK 1015

Query: 208  LLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSE-- 265
            +LR+ RVLR L+ + + + ++ ++  +  A++++  ++++  +  ++FA  GV +F    
Sbjct: 1016 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1075

Query: 266  YTRS----------------------------PRQDLEYHVFFSDLPNSLVTVFILFTLD 297
            YT S                            PR        F ++  +++ +F + T +
Sbjct: 1076 YTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFE 1135

Query: 298  HWYALL--------QDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQ 345
             W  LL        +D   +    R+  SI+FI+++++ +    +I V  ++  FQ
Sbjct: 1136 GWPELLYRSIDSHTEDKGPIYNY-RVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQ 1190


>gi|193788720 calcium channel, voltage-dependent, L type, alpha 1C
           subunit isoform 1 [Homo sapiens]
          Length = 2221

 Score = 94.0 bits (232), Expect = 3e-19
 Identities = 86/344 (25%), Positives = 154/344 (44%), Gaps = 32/344 (9%)

Query: 85  SRLHVRCSQRPPLSLWAGWVLECP----------LFKNFIIFLVFLNTIILMVEIELLES 134
           +RL  R S+      W  W   C           +F   +IFLVFLNT+ +  E      
Sbjct: 491 ARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASE-----H 545

Query: 135 TNTKLWPLKLTLEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSLLPEV 193
            N   W L    + A   +L +F  E+LLK  S     ++ S +N FD  V    +L  +
Sbjct: 546 YNQPNW-LTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETI 604

Query: 194 VVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFY 253
           +V   +    + + +LR  R+LR  K+   +  +  ++  L+ +++S+  LL+LL +F  
Sbjct: 605 LVETKIMSP-LGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFII 663

Query: 254 IFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQD---VWKVP 310
           IF++ G+ +F               F  + P SL+TVF + T + W +++ D    +  P
Sbjct: 664 IFSLLGMQLFGGKFNFDEMQTRRSTF-DNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGP 722

Query: 311 EVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTN------FQNIRKELNEEMARREVQLKA 364
               +   IYFI+  + G+ I  ++ +A+ V N        + +KE  EE  R+++   A
Sbjct: 723 SFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTA 782

Query: 365 DMFKRQIIQRRKNMSHEALTSSHSKIEDRGASQQRESLDLSEVS 408
              K+Q +  +  +      S   KIE +  +   ES   ++++
Sbjct: 783 SPEKKQELVEKPAVGE----SKEEKIELKSITADGESPPATKIN 822



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 60/300 (20%), Positives = 136/300 (45%), Gaps = 52/300 (17%)

Query: 103  WVLECPLFKNFIIFLVFLNTIILMVE-----------IELLESTNTKLWPLKLTLEVAAW 151
            +V+    F+  +  L+ LNTI L ++           + +L    T L+ +++ L++ A+
Sbjct: 1234 YVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAF 1293

Query: 152  ------------FILLIFILEILLKWLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGV 199
                        F  LI I  I+   LS  + ++  AWN FD ++ + S++   +  V  
Sbjct: 1294 KPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNP 1353

Query: 200  TGQS-------------VWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLM 246
               +             + +   R+ RV+R +KLL++   I+ ++   +++ +++ ++ +
Sbjct: 1354 AEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVAL 1413

Query: 247  LLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHW----YAL 302
            L+++ F+I+AV G+ VF +   +   ++  +  F   P +++ +F   T + W     A 
Sbjct: 1414 LIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLAC 1473

Query: 303  LQDVWKVPE------------VSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKE 350
            +      PE                F+  YFI + +L + +  ++ VA+++ NF  + ++
Sbjct: 1474 MPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRD 1533



 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 69/320 (21%), Positives = 138/320 (43%), Gaps = 62/320 (19%)

Query: 104 VLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILL 163
           ++E   F+  I+  +F N + L + I   E  +         LE   +  L+IF +E  L
Sbjct: 120 IVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNAT---NSNLERVEYLFLIIFTVEAFL 176

Query: 164 KWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVV---------LVGVTGQSVWLQLL 209
           K ++   +F  +A     WN+ DF++ ++ L   ++           +G  G    ++ L
Sbjct: 177 KVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKAL 236

Query: 210 RICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------ 263
           R  RVLR L+L++    +Q+++  +++A+  +  + +L+L    I+A+ G+ +F      
Sbjct: 237 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296

Query: 264 ------------SEYTRSP--------RQ-----------DLEYH--VFFSDLPNSLVTV 290
                       +E   SP        RQ           D   H    F +   +++TV
Sbjct: 297 TCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTV 356

Query: 291 FILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKE 350
           F   T++ W  +L   W    V R +  IYF+  +++GS    ++++ ++   F   R++
Sbjct: 357 FQCITMEGWTDVL--YWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREK 414

Query: 351 LNE----EMARREVQLKADM 366
                  +  R + QL+ D+
Sbjct: 415 AKARGDFQKLREKQQLEEDL 434



 Score = 55.8 bits (133), Expect = 9e-08
 Identities = 59/296 (19%), Positives = 133/296 (44%), Gaps = 65/296 (21%)

Query: 109  LFKNFIIFLVFLNTIILMVE------------IELLESTNTKLWPLKLTLEV---AAWFI 153
            +F N I+F + L++I L  E            +   +   T ++ +++ L++   A +  
Sbjct: 901  IFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKILGNADYVF 960

Query: 154  LLIFILEILLKWLS-----NFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV-WLQ 207
              IF LEI+LK  +     +   F ++ +N+ D +V  +SL+       G+   ++  ++
Sbjct: 961  TSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLIS-----FGIQSSAINVVK 1015

Query: 208  LLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSE-- 265
            +LR+ RVLR L+ + + + ++ ++  +  A++++  ++++  +  ++FA  GV +F    
Sbjct: 1016 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1075

Query: 266  YTRS----------------------------PRQDLEYHVFFSDLPNSLVTVFILFTLD 297
            YT S                            PR        F ++  +++ +F + T +
Sbjct: 1076 YTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFE 1135

Query: 298  HWYALL--------QDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQ 345
             W  LL        +D   +    R+  SI+FI+++++ +    +I V  ++  FQ
Sbjct: 1136 GWPELLYRSIDSHTEDKGPIYNY-RVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQ 1190


>gi|120433602 calcium channel, voltage-dependent, L type, alpha 1C
           subunit isoform 18 [Homo sapiens]
          Length = 2138

 Score = 94.0 bits (232), Expect = 3e-19
 Identities = 86/344 (25%), Positives = 154/344 (44%), Gaps = 32/344 (9%)

Query: 85  SRLHVRCSQRPPLSLWAGWVLECP----------LFKNFIIFLVFLNTIILMVEIELLES 134
           +RL  R S+      W  W   C           +F   +IFLVFLNT+ +  E      
Sbjct: 491 ARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASE-----H 545

Query: 135 TNTKLWPLKLTLEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSLLPEV 193
            N   W L    + A   +L +F  E+LLK  S     ++ S +N FD  V    +L  +
Sbjct: 546 YNQPNW-LTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETI 604

Query: 194 VVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFY 253
           +V   +    + + +LR  R+LR  K+   +  +  ++  L+ +++S+  LL+LL +F  
Sbjct: 605 LVETKIMSP-LGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFII 663

Query: 254 IFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQD---VWKVP 310
           IF++ G+ +F               F  + P SL+TVF + T + W +++ D    +  P
Sbjct: 664 IFSLLGMQLFGGKFNFDEMQTRRSTF-DNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGP 722

Query: 311 EVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTN------FQNIRKELNEEMARREVQLKA 364
               +   IYFI+  + G+ I  ++ +A+ V N        + +KE  EE  R+++   A
Sbjct: 723 SFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTA 782

Query: 365 DMFKRQIIQRRKNMSHEALTSSHSKIEDRGASQQRESLDLSEVS 408
              K+Q +  +  +      S   KIE +  +   ES   ++++
Sbjct: 783 SPEKKQELVEKPAVGE----SKEEKIELKSITADGESPPATKIN 822



 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 69/320 (21%), Positives = 138/320 (43%), Gaps = 62/320 (19%)

Query: 104 VLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILL 163
           ++E   F+  I+  +F N + L + I   E  +         LE   +  L+IF +E  L
Sbjct: 120 IVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNAT---NSNLERVEYLFLIIFTVEAFL 176

Query: 164 KWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVV---------LVGVTGQSVWLQLL 209
           K ++   +F  +A     WN+ DF++ ++ L   ++           +G  G    ++ L
Sbjct: 177 KVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKAL 236

Query: 210 RICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------ 263
           R  RVLR L+L++    +Q+++  +++A+  +  + +L+L    I+A+ G+ +F      
Sbjct: 237 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296

Query: 264 ------------SEYTRSP--------RQ-----------DLEYH--VFFSDLPNSLVTV 290
                       +E   SP        RQ           D   H    F +   +++TV
Sbjct: 297 TCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTV 356

Query: 291 FILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKE 350
           F   T++ W  +L   W    V R +  IYF+  +++GS    ++++ ++   F   R++
Sbjct: 357 FQCITMEGWTDVL--YWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREK 414

Query: 351 LNE----EMARREVQLKADM 366
                  +  R + QL+ D+
Sbjct: 415 AKARGDFQKLREKQQLEEDL 434



 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 53/278 (19%), Positives = 128/278 (46%), Gaps = 36/278 (12%)

Query: 103  WVLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEIL 162
            +V+    F+  +  L+ LNTI L ++         +    K+ + +       +F +E++
Sbjct: 1214 YVVNSTYFEYLMFVLILLNTICLAMQ------HYGQSCLFKIAMNILNMLFTGLFTVEMI 1267

Query: 163  LKWLS-NFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQS-------------VWLQL 208
            LK ++     ++  AWN FD ++ + S++   +  V     +             + +  
Sbjct: 1268 LKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITF 1327

Query: 209  LRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTR 268
             R+ RV+R +KLL++   I+ ++   +++ +++ ++ +L+++ F+I+AV G+ VF +   
Sbjct: 1328 FRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIAL 1387

Query: 269  SPRQDLEYHVFFSDLPNSLVTVFILFTLDHW----YALLQDVWKVPE------------V 312
            +   ++  +  F   P +++ +F   T + W     A +      PE             
Sbjct: 1388 NDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPC 1447

Query: 313  SRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKE 350
               F+  YFI + +L + +  ++ VA+++ NF  + ++
Sbjct: 1448 GSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRD 1485



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 57/283 (20%), Positives = 125/283 (44%), Gaps = 59/283 (20%)

Query: 109  LFKNFIIFLVFLNTIILMVE--IELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWL 166
            +F N I+F + L++I L  E  ++     N  L+   +           IF +EI LK  
Sbjct: 901  IFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTT-------IFTIEIALKMT 953

Query: 167  S-----NFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV-WLQLLRICRVLRSLKL 220
            +     +   F ++ +N+ D +V  +SL+       G+   ++  +++LR+ RVLR L+ 
Sbjct: 954  AYGAFLHKGSFCRNYFNILDLLVVSVSLIS-----FGIQSSAINVVKILRVLRVLRPLRA 1008

Query: 221  LAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSE--YTRS--------- 269
            + + + ++ ++  +  A++++  ++++  +  ++FA  GV +F    YT S         
Sbjct: 1009 INRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAE 1068

Query: 270  -------------------PRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALL------- 303
                               PR        F ++  +++ +F + T + W  LL       
Sbjct: 1069 CKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSH 1128

Query: 304  -QDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQ 345
             +D   +    R+  SI+FI+++++ +    +I V  ++  FQ
Sbjct: 1129 TEDKGPIYNY-RVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQ 1170


>gi|193788548 calcium channel, voltage-dependent, L type, alpha 1C
           subunit isoform 20 [Homo sapiens]
          Length = 2127

 Score = 94.0 bits (232), Expect = 3e-19
 Identities = 86/344 (25%), Positives = 154/344 (44%), Gaps = 32/344 (9%)

Query: 85  SRLHVRCSQRPPLSLWAGWVLECP----------LFKNFIIFLVFLNTIILMVEIELLES 134
           +RL  R S+      W  W   C           +F   +IFLVFLNT+ +  E      
Sbjct: 491 ARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASE-----H 545

Query: 135 TNTKLWPLKLTLEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSLLPEV 193
            N   W L    + A   +L +F  E+LLK  S     ++ S +N FD  V    +L  +
Sbjct: 546 YNQPNW-LTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETI 604

Query: 194 VVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFY 253
           +V   +    + + +LR  R+LR  K+   +  +  ++  L+ +++S+  LL+LL +F  
Sbjct: 605 LVETKIMSP-LGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFII 663

Query: 254 IFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQD---VWKVP 310
           IF++ G+ +F               F  + P SL+TVF + T + W +++ D    +  P
Sbjct: 664 IFSLLGMQLFGGKFNFDEMQTRRSTF-DNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGP 722

Query: 311 EVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTN------FQNIRKELNEEMARREVQLKA 364
               +   IYFI+  + G+ I  ++ +A+ V N        + +KE  EE  R+++   A
Sbjct: 723 SFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTA 782

Query: 365 DMFKRQIIQRRKNMSHEALTSSHSKIEDRGASQQRESLDLSEVS 408
              K+Q +  +  +      S   KIE +  +   ES   ++++
Sbjct: 783 SPEKKQELVEKPAVGE----SKEEKIELKSITADGESPPATKIN 822



 Score = 73.6 bits (179), Expect = 4e-13
 Identities = 53/267 (19%), Positives = 129/267 (48%), Gaps = 25/267 (9%)

Query: 103  WVLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEIL 162
            +V+    F+  +  L+ LNTI L ++         +    K+ + +       +F +E++
Sbjct: 1214 YVVNSTYFEYLMFVLILLNTICLAMQ------HYGQSCLFKIAMNILNMLFTGLFTVEMI 1267

Query: 163  LKWLS-NFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQS--VWLQLLRICRVLRSLK 219
            LK ++     ++  AWN FD ++ + S++   +  V    ++  + +   R+ RV+R +K
Sbjct: 1268 LKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRLVK 1327

Query: 220  LLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHVF 279
            LL++   I+ ++   +++ +++ ++ +L+++ F+I+AV G+ VF +   +   ++  +  
Sbjct: 1328 LLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNN 1387

Query: 280  FSDLPNSLVTVFILFTLDHW----YALLQDVWKVPE------------VSRIFSSIYFIL 323
            F   P +++ +F   T + W     A +      PE                F+  YFI 
Sbjct: 1388 FQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFIS 1447

Query: 324  WLLLGSIIFRSIIVAMMVTNFQNIRKE 350
            + +L + +  ++ VA+++ NF  + ++
Sbjct: 1448 FYMLCAFLIINLFVAVIMDNFDYLTRD 1474



 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 69/320 (21%), Positives = 138/320 (43%), Gaps = 62/320 (19%)

Query: 104 VLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILL 163
           ++E   F+  I+  +F N + L + I   E  +         LE   +  L+IF +E  L
Sbjct: 120 IVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNAT---NSNLERVEYLFLIIFTVEAFL 176

Query: 164 KWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVV---------LVGVTGQSVWLQLL 209
           K ++   +F  +A     WN+ DF++ ++ L   ++           +G  G    ++ L
Sbjct: 177 KVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKAL 236

Query: 210 RICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------ 263
           R  RVLR L+L++    +Q+++  +++A+  +  + +L+L    I+A+ G+ +F      
Sbjct: 237 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296

Query: 264 ------------SEYTRSP--------RQ-----------DLEYH--VFFSDLPNSLVTV 290
                       +E   SP        RQ           D   H    F +   +++TV
Sbjct: 297 TCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTV 356

Query: 291 FILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKE 350
           F   T++ W  +L   W    V R +  IYF+  +++GS    ++++ ++   F   R++
Sbjct: 357 FQCITMEGWTDVL--YWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREK 414

Query: 351 LNE----EMARREVQLKADM 366
                  +  R + QL+ D+
Sbjct: 415 AKARGDFQKLREKQQLEEDL 434



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 59/281 (20%), Positives = 129/281 (45%), Gaps = 55/281 (19%)

Query: 109  LFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWLS- 167
            +F N I+F + L++I L  E + ++ T+ +       L  A +    IF LEI+LK  + 
Sbjct: 901  IFTNLILFFILLSSISLAAE-DPVQHTSFR----NHILGNADYVFTSIFTLEIILKMTAY 955

Query: 168  ----NFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV-WLQLLRICRVLRSLKLLA 222
                +   F ++ +N+ D +V  +SL+       G+   ++  +++LR+ RVLR L+ + 
Sbjct: 956  GAFLHKGSFCRNYFNILDLLVVSVSLIS-----FGIQSSAINVVKILRVLRVLRPLRAIN 1010

Query: 223  QFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSE--YTRS----------- 269
            + + ++ ++  +  A++++  ++++  +  ++FA  GV +F    YT S           
Sbjct: 1011 RAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECK 1070

Query: 270  -----------------PRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALL--------Q 304
                             PR        F ++  +++ +F + T + W  LL        +
Sbjct: 1071 GNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTE 1130

Query: 305  DVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQ 345
            D   +    R+  SI+FI+++++ +    +I V  ++  FQ
Sbjct: 1131 DKGPIYNY-RVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQ 1170


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.325    0.136    0.397 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,898,573
Number of Sequences: 37866
Number of extensions: 670700
Number of successful extensions: 5834
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 115
Number of HSP's successfully gapped in prelim test: 138
Number of HSP's that attempted gapping in prelim test: 4352
Number of HSP's gapped (non-prelim): 842
length of query: 528
length of database: 18,247,518
effective HSP length: 107
effective length of query: 421
effective length of database: 14,195,856
effective search space: 5976455376
effective search space used: 5976455376
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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