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Search of human proteins with 110735439
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|110735439 Werner syndrome protein [Homo sapiens]
(1432 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|110735439 Werner syndrome protein [Homo sapiens] 2868 0.0
gi|169218196 PREDICTED: similar to Werner syndrome ATP-dependent... 2285 0.0
gi|14591902 RecQ protein-like [Homo sapiens] 248 2e-65
gi|14591904 RecQ protein-like [Homo sapiens] 248 2e-65
gi|4557365 Bloom syndrome protein [Homo sapiens] 221 4e-57
gi|148612816 RecQ protein-like 5 isoform 1 [Homo sapiens] 214 4e-55
gi|51242943 RecQ protein-like 5 isoform 3 [Homo sapiens] 212 2e-54
gi|51242947 RecQ protein-like 5 isoform 2 [Homo sapiens] 212 2e-54
gi|116812616 RecQ protein-like 4 [Homo sapiens] 167 9e-41
gi|145279204 exonuclease 3'-5' domain containing 3 [Homo sapiens] 64 1e-09
gi|41327773 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 [Homo sapi... 64 1e-09
gi|8922631 exonuclease 3'-5' domain containing 2 [Homo sapiens] 61 9e-09
gi|87196351 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3 [Homo... 60 2e-08
gi|148613856 DEAD box polypeptide 17 isoform 3 [Homo sapiens] 59 3e-08
gi|38201710 DEAD box polypeptide 17 isoform 1 [Homo sapiens] 59 3e-08
gi|169881239 DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked ... 56 2e-07
gi|13514809 DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked [... 56 2e-07
gi|45446747 DEAD box polypeptide 42 protein [Homo sapiens] 56 3e-07
gi|45446743 DEAD box polypeptide 42 protein [Homo sapiens] 56 3e-07
gi|13129006 nucleolar protein GU2 [Homo sapiens] 55 4e-07
gi|7661920 eukaryotic translation initiation factor 4A, isoform ... 55 5e-07
gi|4758138 DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 [Homo sapiens] 55 6e-07
gi|222352149 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 [Homo sap... 52 3e-06
gi|38569503 ATP-dependent RNA helicase ROK1 isoform b [Homo sapi... 52 4e-06
gi|38569505 ATP-dependent RNA helicase ROK1 isoform a [Homo sapi... 52 4e-06
gi|164664518 DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 [Homo sapi... 52 5e-06
gi|188035877 DEAD (Asp-Glu-Ala-Asp) box polypeptide 59 [Homo sap... 51 7e-06
gi|4503529 eukaryotic translation initiation factor 4A isoform 1... 50 1e-05
gi|41327771 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 [Homo sapi... 50 2e-05
gi|9966805 DEAD (Asp-Glu-Ala-Asp) box polypeptide 24 [Homo sapiens] 50 2e-05
>gi|110735439 Werner syndrome protein [Homo sapiens]
Length = 1432
Score = 2868 bits (7436), Expect = 0.0
Identities = 1432/1432 (100%), Positives = 1432/1432 (100%)
Query: 1 MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDAS 60
MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDAS
Sbjct: 1 MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDAS 60
Query: 61 DCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVF 120
DCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVF
Sbjct: 61 DCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVF 120
Query: 121 PQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSL 180
PQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSL
Sbjct: 121 PQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSL 180
Query: 181 VKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAIN 240
VKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAIN
Sbjct: 181 VKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAIN 240
Query: 241 KEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMII 300
KEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMII
Sbjct: 241 KEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMII 300
Query: 301 GSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGE 360
GSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGE
Sbjct: 301 GSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGE 360
Query: 361 DVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYK 420
DVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYK
Sbjct: 361 DVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYK 420
Query: 421 STEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLE 480
STEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLE
Sbjct: 421 STEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLE 480
Query: 481 NLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCL 540
NLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCL
Sbjct: 481 NLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCL 540
Query: 541 KMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLIS 600
KMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLIS
Sbjct: 541 KMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLIS 600
Query: 601 LMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADI 660
LMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADI
Sbjct: 601 LMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADI 660
Query: 661 GITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNL 720
GITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNL
Sbjct: 661 GITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNL 720
Query: 721 RNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQV 780
RNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQV
Sbjct: 721 RNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQV 780
Query: 781 TGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYG 840
TGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYG
Sbjct: 781 TGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYG 840
Query: 841 APKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKME 900
APKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKME
Sbjct: 841 APKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKME 900
Query: 901 KYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFG 960
KYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFG
Sbjct: 901 KYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFG 960
Query: 961 PQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSR 1020
PQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSR
Sbjct: 961 PQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSR 1020
Query: 1021 QLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSK 1080
QLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSK
Sbjct: 1021 QLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSK 1080
Query: 1081 TVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSS 1140
TVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSS
Sbjct: 1081 TVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSS 1140
Query: 1141 SQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKR 1200
SQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKR
Sbjct: 1141 SQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKR 1200
Query: 1201 IDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMA 1260
IDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMA
Sbjct: 1201 IDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMA 1260
Query: 1261 ITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVI 1320
ITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVI
Sbjct: 1261 ITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVI 1320
Query: 1321 RNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEE 1380
RNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEE
Sbjct: 1321 RNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEE 1380
Query: 1381 ICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS 1432
ICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS
Sbjct: 1381 ICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS 1432
>gi|169218196 PREDICTED: similar to Werner syndrome ATP-dependent
helicase, partial [Homo sapiens]
Length = 1140
Score = 2285 bits (5922), Expect = 0.0
Identities = 1139/1140 (99%), Positives = 1139/1140 (99%)
Query: 293 YSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLD 352
YSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLD
Sbjct: 1 YSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLD 60
Query: 353 HLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEE 412
HLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEE
Sbjct: 61 HLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEE 120
Query: 413 YLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLE 472
YLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLE
Sbjct: 121 YLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLE 180
Query: 473 MEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAP 532
MEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAP
Sbjct: 181 MEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAP 240
Query: 533 NEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIG 592
NEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIG
Sbjct: 241 NEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIG 300
Query: 593 LVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGL 652
LVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGL
Sbjct: 301 LVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGL 360
Query: 653 LQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIRE 712
LQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIRE
Sbjct: 361 LQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIRE 420
Query: 713 DIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCP 772
DIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCP
Sbjct: 421 DIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCP 480
Query: 773 SRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKAD 832
SRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKAD
Sbjct: 481 SRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKAD 540
Query: 833 IRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYK 892
IRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYK
Sbjct: 541 IRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYK 600
Query: 893 LKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDS 952
LKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDS
Sbjct: 601 LKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDS 660
Query: 953 EDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTE 1012
EDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTE
Sbjct: 661 EDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTE 720
Query: 1013 SWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPK 1072
SWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPK
Sbjct: 721 SWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPK 780
Query: 1073 KLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQ 1132
K LLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQ
Sbjct: 781 KFLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQ 840
Query: 1133 SPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRP 1192
SPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRP
Sbjct: 841 SPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRP 900
Query: 1193 TTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKI 1252
TTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKI
Sbjct: 901 TTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKI 960
Query: 1253 CTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEV 1312
CTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEV
Sbjct: 961 CTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEV 1020
Query: 1313 QKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKR 1372
QKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKR
Sbjct: 1021 QKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKR 1080
Query: 1373 RCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS 1432
RCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS
Sbjct: 1081 RCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS 1140
>gi|14591902 RecQ protein-like [Homo sapiens]
Length = 649
Score = 248 bits (634), Expect = 2e-65
Identities = 159/481 (33%), Positives = 249/481 (51%), Gaps = 35/481 (7%)
Query: 509 EEDDENEANEGEED----DDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEER 564
E+ D +NE + + +DF W ++ L+ F F+P+Q + I+ V
Sbjct: 51 EDSDAGASNEYDSSPAAWNKEDFPWSGKVKD---ILQNVFKLEKFRPLQLETIN-VTMAG 106
Query: 565 RDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQS 624
++ VM TG GKSLC+Q P + LVI PLISLMEDQ++ LK I A L ++ S
Sbjct: 107 KEVFLVMPTGGGKSLCYQLPALCSDGFTLVICPLISLMEDQLMVLKQLGISATMLNASSS 166
Query: 625 ENVLTDI------KLGKYRIVYVTPEYCSGNMGLLQQLEADIG---ITLIAVDEAHCISE 675
+ + + K + +++YVTPE + + + +LE T IAVDE HC S+
Sbjct: 167 KEHVKWVHAEMVNKNSELKLIYVTPEKIAKSKMFMSRLEKAYEARRFTRIAVDEVHCCSQ 226
Query: 676 WGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNL 735
WGHDFR ++ LG LK P ++ LTATA++ + D + L + F+RPNL
Sbjct: 227 WGHDFRPDYKALGILKRQFPNASLIGLTATATNHVLTDAQKILCIEKCFTFTASFNRPNL 286
Query: 736 YLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYH 795
Y EVR+K N ++ + + ++ + IIYC S+K ++QVT L+ L + G YH
Sbjct: 287 YYEVRQKPSNTEDFIEDIVKLINGRYKGQSG-IIYCFSQKDSEQVTVSLQNLGIHAGAYH 345
Query: 796 AGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRA 855
A + + +H ++ +EIQ V+AT+AFGMGI+K D+R VIH+ K ME+YYQE GRA
Sbjct: 346 ANLEPEDKTTVHRKWSANEIQVVVATVAFGMGIDKPDVRFVIHHSMSKSMENYYQESGRA 405
Query: 856 GRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILS 915
GRD +++ C + + DI ++ + +LY++ + + S+CRR ++
Sbjct: 406 GRDDMKADCILYYGFGDIFRISSMVVMENVGQQKLYEMVSYCQ-----NISKCRRVLMAQ 460
Query: 916 HFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGE 975
HF++ +A K CDNC C ++ K+L + L E
Sbjct: 461 HFDEVWNSEA------CNKMCDNC------CKDSAFERKNITEYCRDLIKILKQAEELNE 508
Query: 976 K 976
K
Sbjct: 509 K 509
>gi|14591904 RecQ protein-like [Homo sapiens]
Length = 649
Score = 248 bits (634), Expect = 2e-65
Identities = 159/481 (33%), Positives = 249/481 (51%), Gaps = 35/481 (7%)
Query: 509 EEDDENEANEGEED----DDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEER 564
E+ D +NE + + +DF W ++ L+ F F+P+Q + I+ V
Sbjct: 51 EDSDAGASNEYDSSPAAWNKEDFPWSGKVKD---ILQNVFKLEKFRPLQLETIN-VTMAG 106
Query: 565 RDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQS 624
++ VM TG GKSLC+Q P + LVI PLISLMEDQ++ LK I A L ++ S
Sbjct: 107 KEVFLVMPTGGGKSLCYQLPALCSDGFTLVICPLISLMEDQLMVLKQLGISATMLNASSS 166
Query: 625 ENVLTDI------KLGKYRIVYVTPEYCSGNMGLLQQLEADIG---ITLIAVDEAHCISE 675
+ + + K + +++YVTPE + + + +LE T IAVDE HC S+
Sbjct: 167 KEHVKWVHAEMVNKNSELKLIYVTPEKIAKSKMFMSRLEKAYEARRFTRIAVDEVHCCSQ 226
Query: 676 WGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNL 735
WGHDFR ++ LG LK P ++ LTATA++ + D + L + F+RPNL
Sbjct: 227 WGHDFRPDYKALGILKRQFPNASLIGLTATATNHVLTDAQKILCIEKCFTFTASFNRPNL 286
Query: 736 YLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYH 795
Y EVR+K N ++ + + ++ + IIYC S+K ++QVT L+ L + G YH
Sbjct: 287 YYEVRQKPSNTEDFIEDIVKLINGRYKGQSG-IIYCFSQKDSEQVTVSLQNLGIHAGAYH 345
Query: 796 AGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRA 855
A + + +H ++ +EIQ V+AT+AFGMGI+K D+R VIH+ K ME+YYQE GRA
Sbjct: 346 ANLEPEDKTTVHRKWSANEIQVVVATVAFGMGIDKPDVRFVIHHSMSKSMENYYQESGRA 405
Query: 856 GRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILS 915
GRD +++ C + + DI ++ + +LY++ + + S+CRR ++
Sbjct: 406 GRDDMKADCILYYGFGDIFRISSMVVMENVGQQKLYEMVSYCQ-----NISKCRRVLMAQ 460
Query: 916 HFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGE 975
HF++ +A K CDNC C ++ K+L + L E
Sbjct: 461 HFDEVWNSEA------CNKMCDNC------CKDSAFERKNITEYCRDLIKILKQAEELNE 508
Query: 976 K 976
K
Sbjct: 509 K 509
>gi|4557365 Bloom syndrome protein [Homo sapiens]
Length = 1417
Score = 221 bits (563), Expect = 4e-57
Identities = 147/426 (34%), Positives = 230/426 (53%), Gaps = 20/426 (4%)
Query: 534 EEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGL 593
+E + FG +F+ Q + I++ L D +M TG GKSLC+Q P + +
Sbjct: 653 KEMMKIFHKKFGLHNFRTNQLEAINAALLGE-DCFILMPTGGGKSLCYQLPACVSPGVTV 711
Query: 594 VISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDI--KLGK----YRIVYVTPEYCS 647
VISPL SL+ DQV +L +IPA +L ++++ T+I +L K +++YVTPE
Sbjct: 712 VISPLRSLIVDQVQKLTSLDIPATYLTGDKTDSEATNIYLQLSKKDPIIKLLYVTPEKIC 771
Query: 648 GNMGLLQQLEADIGITLIA---VDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTA 704
+ L+ LE L+A +DEAHC+S+WGHDFR ++++ L+ P VP++ALTA
Sbjct: 772 ASNRLISTLENLYERKLLARFVIDEAHCVSQWGHDFRQDYKRMNMLRQKFPSVPVMALTA 831
Query: 705 TASSSIREDIVRCLNLRNPQITCTGFDRPNL-YLEVRRKTGNILQDLQPFLVKTSSHWEF 763
TA+ +++DI+ L + PQ+ F+R NL Y + +K + D ++ K H +
Sbjct: 832 TANPRVQKDILTQLKILRPQVFSMSFNRHNLKYYVLPKKPKKVAFDCLEWIRK---HHPY 888
Query: 764 EGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFV-RDEIQCVIATI 822
+ IIYC SR+ + L++ L+ YHAG+S S R ++ +++ +D Q + ATI
Sbjct: 889 DS-GIIYCLSRRECDTMADTLQRDGLAALAYHAGLSDSARDEVQQKWINQDGCQVICATI 947
Query: 823 AFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTE 882
AFGMGI+K D+R VIH PK +E YYQE GRAGRDG S C + + D+ + L+
Sbjct: 948 AFGMGIDKPDVRFVIHASLPKSVEGYYQESGRAGRDGEISHCLLFYTYHDVTRLKRLIMM 1007
Query: 883 IR--NEKFRLYKLKMMAKMEKYLHS-SRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNC 939
+ N R + M Y + + CRR +L++F + + CDNC
Sbjct: 1008 EKDGNHHTRETHFNNLYSMVHYCENITECRRIQLLAYFGENGF-NPDFCKKHPDVSCDNC 1066
Query: 940 RSRLDH 945
D+
Sbjct: 1067 CKTKDY 1072
>gi|148612816 RecQ protein-like 5 isoform 1 [Homo sapiens]
Length = 991
Score = 214 bits (546), Expect = 4e-55
Identities = 144/437 (32%), Positives = 237/437 (54%), Gaps = 39/437 (8%)
Query: 532 PNEEQVTCLKMYFGHSSFK-PVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGK 590
P + LK FG SFK P+Q +V++ +D M TG GKSLC+Q P +
Sbjct: 12 PERRVRSTLKKVFGFDSFKTPLQESATMAVVKGNKDVFVCMPTGAGKSLCYQLPALLAKG 71
Query: 591 IGLVISPLISLMEDQV-----LQLKMSNIPACFLGSAQSENVLTDIKLGK--YRIVYVTP 643
I +V+SPLI+L++DQV L++++S++ + L + + + +L D++ K +I+Y+TP
Sbjct: 72 ITIVVSPLIALIQDQVDHLLTLKVRVSSLNSK-LSAQERKELLADLEREKPQTKILYITP 130
Query: 644 EYCSGN--MGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVA 701
E + + L L + ++ + VDEAHC+S+WGHDFR + +LG+L++ L P VA
Sbjct: 131 EMAASSSFQPTLNSLVSRHLLSYLVVDEAHCVSQWGHDFRPDYLRLGALRSRLGHAPCVA 190
Query: 702 LTATASSSIREDIVRCLNLRNP-QITCTGFDRPNLYLEVRRKT--GNILQDLQPFLVKTS 758
LTATA+ ++ED+ L+L+ P I T R NL+ +V+ K + +L+ F +K
Sbjct: 191 LTATATPQVQEDVFAALHLKKPVAIFKTPCFRANLFYDVQFKELISDPYGNLKDFCLKAL 250
Query: 759 SHWEFEGPT---IIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEI 815
+G + I+YC +R+ +Q+ EL ++ YHAG+ S R + + ++ +++
Sbjct: 251 GQEADKGLSGCGIVYCRTREACEQLAIELSCRGVNAKAYHAGLKASERTLVQNDWMEEKV 310
Query: 816 QCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINL 875
++ATI+FGMG++KA++R V H+ K M YYQE GRAGRDG S C + ++ D +
Sbjct: 311 PVIVATISFGMGVDKANVRFVAHWNIAKSMAGYYQESGRAGRDGKPSWCRLYYSRNDRDQ 370
Query: 876 NRHLLTEIRNEKFRLY---------KLKMMA--KMEKYLHSSRCRRQIILSHFEDKQVQK 924
L IR E +L K +MA + + CR I +F D
Sbjct: 371 VSFL---IRKEVAKLQEKRGNKASDKATIMAFDALVTFCEELGCRHAAIAKYFGD----- 422
Query: 925 ASLGIMGTEKCCDNCRS 941
+ K CD+C++
Sbjct: 423 ---ALPACAKGCDHCQN 436
>gi|51242943 RecQ protein-like 5 isoform 3 [Homo sapiens]
Length = 410
Score = 212 bits (539), Expect = 2e-54
Identities = 127/357 (35%), Positives = 210/357 (58%), Gaps = 17/357 (4%)
Query: 532 PNEEQVTCLKMYFGHSSFK-PVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGK 590
P + LK FG SFK P+Q +V++ +D M TG GKSLC+Q P +
Sbjct: 12 PERRVRSTLKKVFGFDSFKTPLQESATMAVVKGNKDVFVCMPTGAGKSLCYQLPALLAKG 71
Query: 591 IGLVISPLISLMEDQV-----LQLKMSNIPACFLGSAQSENVLTDIKLGK--YRIVYVTP 643
I +V+SPLI+L++DQV L++++S++ + L + + + +L D++ K +I+Y+TP
Sbjct: 72 ITIVVSPLIALIQDQVDHLLTLKVRVSSLNSK-LSAQERKELLADLEREKPQTKILYITP 130
Query: 644 EYCSGN--MGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVA 701
E + + L L + ++ + VDEAHC+S+WGHDFR + +LG+L++ L P VA
Sbjct: 131 EMAASSSFQPTLNSLVSRHLLSYLVVDEAHCVSQWGHDFRPDYLRLGALRSRLGHAPCVA 190
Query: 702 LTATASSSIREDIVRCLNLRNP-QITCTGFDRPNLYLEVRRKT--GNILQDLQPFLVKTS 758
LTATA+ ++ED+ L+L+ P I T R NL+ +V+ K + +L+ F +K
Sbjct: 191 LTATATPQVQEDVFAALHLKKPVAIFKTPCFRANLFYDVQFKELISDPYGNLKDFCLKAL 250
Query: 759 SHWEFEGPT---IIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEI 815
+G + I+YC +R+ +Q+ EL ++ YHAG+ S R + + ++ +++
Sbjct: 251 GQEADKGLSGCGIVYCRTREACEQLAIELSCRGVNAKAYHAGLKASERTLVQNDWMEEKV 310
Query: 816 QCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPAD 872
++ATI+FGMG++KA++R V H+ K M YYQE GRAGRDG S C + ++ D
Sbjct: 311 PVIVATISFGMGVDKANVRFVAHWNIAKSMAGYYQESGRAGRDGKPSWCRLYYSRND 367
>gi|51242947 RecQ protein-like 5 isoform 2 [Homo sapiens]
Length = 435
Score = 212 bits (539), Expect = 2e-54
Identities = 127/357 (35%), Positives = 210/357 (58%), Gaps = 17/357 (4%)
Query: 532 PNEEQVTCLKMYFGHSSFK-PVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGK 590
P + LK FG SFK P+Q +V++ +D M TG GKSLC+Q P +
Sbjct: 12 PERRVRSTLKKVFGFDSFKTPLQESATMAVVKGNKDVFVCMPTGAGKSLCYQLPALLAKG 71
Query: 591 IGLVISPLISLMEDQV-----LQLKMSNIPACFLGSAQSENVLTDIKLGK--YRIVYVTP 643
I +V+SPLI+L++DQV L++++S++ + L + + + +L D++ K +I+Y+TP
Sbjct: 72 ITIVVSPLIALIQDQVDHLLTLKVRVSSLNSK-LSAQERKELLADLEREKPQTKILYITP 130
Query: 644 EYCSGN--MGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVA 701
E + + L L + ++ + VDEAHC+S+WGHDFR + +LG+L++ L P VA
Sbjct: 131 EMAASSSFQPTLNSLVSRHLLSYLVVDEAHCVSQWGHDFRPDYLRLGALRSRLGHAPCVA 190
Query: 702 LTATASSSIREDIVRCLNLRNP-QITCTGFDRPNLYLEVRRKT--GNILQDLQPFLVKTS 758
LTATA+ ++ED+ L+L+ P I T R NL+ +V+ K + +L+ F +K
Sbjct: 191 LTATATPQVQEDVFAALHLKKPVAIFKTPCFRANLFYDVQFKELISDPYGNLKDFCLKAL 250
Query: 759 SHWEFEGPT---IIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEI 815
+G + I+YC +R+ +Q+ EL ++ YHAG+ S R + + ++ +++
Sbjct: 251 GQEADKGLSGCGIVYCRTREACEQLAIELSCRGVNAKAYHAGLKASERTLVQNDWMEEKV 310
Query: 816 QCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPAD 872
++ATI+FGMG++KA++R V H+ K M YYQE GRAGRDG S C + ++ D
Sbjct: 311 PVIVATISFGMGVDKANVRFVAHWNIAKSMAGYYQESGRAGRDGKPSWCRLYYSRND 367
>gi|116812616 RecQ protein-like 4 [Homo sapiens]
Length = 1208
Score = 167 bits (422), Expect = 9e-41
Identities = 110/351 (31%), Positives = 177/351 (50%), Gaps = 32/351 (9%)
Query: 545 GHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGK----IGLVISPLIS 600
GH +F+P Q + + +L + V+ TG GKSLC+Q P + + + LV+SPL+S
Sbjct: 477 GHQAFRPGQERAVMRILSGI-STLLVLPTGAGKSLCYQLPALLYSRRSPCLTLVVSPLLS 535
Query: 601 LMEDQVLQLKMSNIPACF---LGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLE 657
LM+DQV L AC + Q E+VL I+ + ++ +TPE G GL +
Sbjct: 536 LMDDQVSGLPPCLKAACIHSGMTRKQRESVLQKIRAAQVHVLMLTPEALVGAGGLPPAAQ 595
Query: 658 ADIGITLIAVDEAHCISEWGHDFRDSFRKLGS-LKTALPMVPIVALTATASSSIREDIVR 716
+ +DEAHC+S+W H+FR + ++ L+ + + + LTATA+ D+ +
Sbjct: 596 LP-PVAFACIDEAHCLSQWSHNFRPCYLRVCKVLRERMGVHCFLGLTATATRRTASDVAQ 654
Query: 717 CLNL-RNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEG--PTIIYCPS 773
L + P + NL+L V ++ +D L+ F+ IIYC
Sbjct: 655 HLAVAEEPDLHGPAPVPTNLHLSV-----SMDRDTDQALLTLLQGKRFQNLDSIIIYCNR 709
Query: 774 RKMTQQVTGELRKL--------------NLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVI 819
R+ T+++ LR + YHAGM R+ + F++ +++ V+
Sbjct: 710 REDTERIAALLRTCLHAAWVPGSGGRAPKTTAEAYHAGMCSRERRRVQRAFMQGQLRVVV 769
Query: 820 ATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAP 870
AT+AFGMG+++ D+R V+H G P ESY Q +GRAGRDG + CH+ P
Sbjct: 770 ATVAFGMGLDRPDVRAVLHLGLPPSFESYVQAVGRAGRDGQPAHCHLFLQP 820
>gi|145279204 exonuclease 3'-5' domain containing 3 [Homo sapiens]
Length = 876
Score = 63.5 bits (153), Expect = 1e-09
Identities = 52/175 (29%), Positives = 85/175 (48%), Gaps = 28/175 (16%)
Query: 78 VVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQG---------LKMLL 128
VVG D+EW P++ G + +L+Q+ V E +L V ++S P G + LL
Sbjct: 395 VVGVDVEWTPVFVAGGRPRPSLLQVAV-EGHVFLLDVLALSQPPTGQGAQAFSRLVAQLL 453
Query: 129 ENKAVKKAGVGIEGDQWKL------LRDFDIKLKNFVELTDVANKKL----------KCT 172
+ ++ K G G+ GD KL L + ++ ++L V + +
Sbjct: 454 SDPSITKLGYGMVGDLQKLGTSCPALAHVEKQILGGMDLLLVHRQMRVASVPAPAVDRAR 513
Query: 173 ETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNL 227
E L+ LV+ +LG L DK+ + SNW + PL E+Q +YAA DAY +++ L
Sbjct: 514 ELRGLSLLVQQVLGTAL--DKTQQLSNWDRRPLCEEQVIYAAADAYCLLEVHQAL 566
>gi|41327773 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 [Homo
sapiens]
Length = 1031
Score = 63.5 bits (153), Expect = 1e-09
Identities = 89/444 (20%), Positives = 172/444 (38%), Gaps = 57/444 (12%)
Query: 458 ENDTSYVIESDEDLEMEMLKSLENLNSGT---VEPTHSKCLKME---RNLGLPTKEEEED 511
END + S E+ E+++ +L + +EP ++ E +N + E +
Sbjct: 286 ENDQDAMEYSSEEEEVDLQTALTGYQTKQRKLLEPVDHGKIEYEPFRKNFYVEVPELAKM 345
Query: 512 DENEAN----EGEEDDDKDFLWPAPNEEQVTC---------LKMYFGHSSFKPVQWKVIH 558
+ E N E E K P P + V C LK + G+ P+Q + I
Sbjct: 346 SQEEVNVFRLEMEGITVKGKGCPKPIKSWVQCGISMKILNSLKKH-GYEKPTPIQTQAIP 404
Query: 559 SVLEERRDNVAVMATGYGKSLCFQYPPVY-----------VGKIGLVISPLISLMEDQVL 607
+++ R D + + TG GK++ F P G I ++++P L
Sbjct: 405 AIMSGR-DLIGIAKTGSGKTIAFLLPMFRHIMDQRSLEEGEGPIAVIMTPTRELALQITK 463
Query: 608 QLKMSNIP-----ACFLGSAQSENVLTDIKLGKYRIVYVTP----EYCSGNMGLLQQLEA 658
+ K + C G + ++K G I+ TP + + N G + L
Sbjct: 464 ECKKFSKTLGLRVVCVYGGTGISEQIAELKRGA-EIIVCTPGRMIDMLAANSGRVTNLRR 522
Query: 659 DIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRC- 717
+T + +DEA + + G + R + +++ V A A ++ I+
Sbjct: 523 ---VTYVVLDEADRMFDMGFE-PQVMRIVDNVRPDRQTVMFSATFPRAMEALARRILSKP 578
Query: 718 --LNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRK 775
+ + + C+ ++ + +E +K +L+ L H++ G II+ ++
Sbjct: 579 IEVQVGGRSVVCSDVEQQVIVIEEEKKFLKLLELL--------GHYQESGSVIIFVDKQE 630
Query: 776 MTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQ 835
+ +L + + C + H G+ R I + F + ++AT G++ +
Sbjct: 631 HADGLLKDLMRASYPCMSLHGGIDQYDRDSIINDFKNGTCKLLVATSVAARGLDVKHLIL 690
Query: 836 VIHYGAPKDMESYYQEIGRAGRDG 859
V++Y P E Y GR GR G
Sbjct: 691 VVNYSCPNHYEDYVHRAGRTGRAG 714
>gi|8922631 exonuclease 3'-5' domain containing 2 [Homo sapiens]
Length = 496
Score = 60.8 bits (146), Expect = 9e-09
Identities = 39/110 (35%), Positives = 60/110 (54%), Gaps = 4/110 (3%)
Query: 121 PQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKK---LKCTETWSL 177
P+ L +L + + K GVG D KLL+D+ + ++ ++L +A ++ L C SL
Sbjct: 24 PRTLLDILADGTILKVGVGCSEDASKLLQDYGLVVRGCLDLRYLAMRQRNNLLCNGL-SL 82
Query: 178 NSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNL 227
SL + +L L K +RCSNW LTEDQ +YAA DA ++ +L
Sbjct: 83 KSLAETVLNFPLDKSLLLRCSNWDAETLTEDQVIYAARDAQISVALFLHL 132
>gi|87196351 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3 [Homo
sapiens]
Length = 662
Score = 59.7 bits (143), Expect = 2e-08
Identities = 93/404 (23%), Positives = 160/404 (39%), Gaps = 66/404 (16%)
Query: 551 PVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYP---PVYVG------------------ 589
PVQ I +++E+RD +A TG GK+ F P +Y
Sbjct: 205 PVQKHAI-PIIKEKRDLMACAQTGSGKTAAFLLPILSQIYSDGPGEALRAMKENGRYGRR 263
Query: 590 ---KIGLVISPLISLM-----EDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYV 641
I LV++P L E + + P G A + D++ G + +V
Sbjct: 264 KQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVVYGGADIGQQIRDLERGCHLLV-A 322
Query: 642 TPEYCSGNMGLLQQLE-ADIGITL---IAVDEAHCISEWGHDFRDSFRKLGSLKTALPMV 697
TP L+ +E IG+ + +DEA + + G F R++ T P
Sbjct: 323 TPGR------LVDMMERGKIGLDFCKYLVLDEADRMLDMG--FEPQIRRIVEQDTMPPKG 374
Query: 698 PIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRR---KTGNILQ------ 748
V T S++ ++I Q+ F ++L V R + NI Q
Sbjct: 375 --VRHTMMFSATFPKEI---------QMLARDFLDEYIFLAVGRVGSTSENITQKVVWVE 423
Query: 749 --DLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDI 806
D + FL+ + + T+++ ++K + L +C + H S R++
Sbjct: 424 ESDKRSFLLDLLNATGKDSLTLVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDREEA 483
Query: 807 HHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHV 866
H+F + ++AT G++ ++++ VI++ P D+E Y IGR GR G
Sbjct: 484 LHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGLATS 543
Query: 867 LWAPADINLNRHLLTEIRNEKFRLYK-LKMMAKMEKYLHSSRCR 909
+ +IN+ + LL + K + L+ MA Y SSR R
Sbjct: 544 FFNERNINITKDLLDLLVEAKQEVPSWLENMAYEHHYKGSSRGR 587
>gi|148613856 DEAD box polypeptide 17 isoform 3 [Homo sapiens]
Length = 731
Score = 59.3 bits (142), Expect = 3e-08
Identities = 85/351 (24%), Positives = 137/351 (39%), Gaps = 60/351 (17%)
Query: 565 RDNVAVMATGYGKSLCFQYPPV-------YV----GKIGLVISPLISLMEDQVLQL---- 609
RD V + TG GK+L + P + Y+ G I LV++P L + QV Q+
Sbjct: 209 RDMVGIAQTGSGKTLAYLLPAIVHINHQPYLERGDGPICLVLAPTRELAQ-QVQQVADDY 267
Query: 610 -KMSNIPA-CFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMG-LLQQLEADIG----I 662
K S + + C G A + D++ G E C G L+ LE+
Sbjct: 268 GKCSRLKSTCIYGGAPKGPQIRDLERGV--------EICIATPGRLIDFLESGKTNLRRC 319
Query: 663 TLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIR---EDIVRCLN 719
T + +DEA + + G F RK+ + P + +AT +R ED +R
Sbjct: 320 TYLVLDEADRMLDMG--FEPQIRKI--VDQIRPDRQTLMWSATWPKEVRQLAEDFLR--- 372
Query: 720 LRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHW----------EFEGPTII 769
T + NL L NILQ + + H E E TII
Sbjct: 373 ------DYTQINVGNLELSANH---NILQIVDVCMESEKDHKLIQLMEEIMAEKENKTII 423
Query: 770 YCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGIN 829
+ +++ +T +R+ H S R + + F + +IAT G++
Sbjct: 424 FVETKRRCDDLTRRMRRDGWPAMCIHGDKSQPERDWVLNEFRSGKAPILIATDVASRGLD 483
Query: 830 KADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLL 880
D++ VI+Y P E Y IGR R + + + + P ++ R L+
Sbjct: 484 VEDVKFVINYDYPNSSEDYVHRIGRTARSTNKGTAYTFFTPGNLKQARELI 534
>gi|38201710 DEAD box polypeptide 17 isoform 1 [Homo sapiens]
Length = 729
Score = 59.3 bits (142), Expect = 3e-08
Identities = 85/351 (24%), Positives = 137/351 (39%), Gaps = 60/351 (17%)
Query: 565 RDNVAVMATGYGKSLCFQYPPV-------YV----GKIGLVISPLISLMEDQVLQL---- 609
RD V + TG GK+L + P + Y+ G I LV++P L + QV Q+
Sbjct: 209 RDMVGIAQTGSGKTLAYLLPAIVHINHQPYLERGDGPICLVLAPTRELAQ-QVQQVADDY 267
Query: 610 -KMSNIPA-CFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMG-LLQQLEADIG----I 662
K S + + C G A + D++ G E C G L+ LE+
Sbjct: 268 GKCSRLKSTCIYGGAPKGPQIRDLERGV--------EICIATPGRLIDFLESGKTNLRRC 319
Query: 663 TLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIR---EDIVRCLN 719
T + +DEA + + G F RK+ + P + +AT +R ED +R
Sbjct: 320 TYLVLDEADRMLDMG--FEPQIRKI--VDQIRPDRQTLMWSATWPKEVRQLAEDFLR--- 372
Query: 720 LRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHW----------EFEGPTII 769
T + NL L NILQ + + H E E TII
Sbjct: 373 ------DYTQINVGNLELSANH---NILQIVDVCMESEKDHKLIQLMEEIMAEKENKTII 423
Query: 770 YCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGIN 829
+ +++ +T +R+ H S R + + F + +IAT G++
Sbjct: 424 FVETKRRCDDLTRRMRRDGWPAMCIHGDKSQPERDWVLNEFRSGKAPILIATDVASRGLD 483
Query: 830 KADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLL 880
D++ VI+Y P E Y IGR R + + + + P ++ R L+
Sbjct: 484 VEDVKFVINYDYPNSSEDYVHRIGRTARSTNKGTAYTFFTPGNLKQARELI 534
>gi|169881239 DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
[Homo sapiens]
Length = 660
Score = 56.2 bits (134), Expect = 2e-07
Identities = 91/404 (22%), Positives = 157/404 (38%), Gaps = 66/404 (16%)
Query: 551 PVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYP---PVYVG------------------ 589
PVQ I +++ +RD +A TG GK+ F P +Y
Sbjct: 203 PVQKHAI-PIIKGKRDLMACAQTGSGKTAAFLLPILSQIYTDGPGEALKAVKENGRYGRR 261
Query: 590 ---KIGLVISPLISLM-----EDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYV 641
I LV++P L E + + P G A + D++ G + +V
Sbjct: 262 KQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVVYGGADIGQQIRDLERGCHLLV-A 320
Query: 642 TPEYCSGNMGLLQQLE-ADIGITL---IAVDEAHCISEWGHDFRDSFRKLGSLKTALPMV 697
TP L+ +E IG+ + +DEA + + G F R++ T P
Sbjct: 321 TPGR------LVDMMERGKIGLDFCKYLVLDEADRMLDMG--FEPQIRRIVEQDTMPPKG 372
Query: 698 PIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRR---KTGNILQ------ 748
V T S++ ++I Q+ F ++L V R + NI Q
Sbjct: 373 --VRHTMMFSATFPKEI---------QMLARDFLDEYIFLAVGRVGSTSENITQKVVWVE 421
Query: 749 --DLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDI 806
D + FL+ + T+++ ++K + L +C + H S R++
Sbjct: 422 DLDKRSFLLDILGATGSDSLTLVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDREEA 481
Query: 807 HHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHV 866
H+F + ++AT G++ +++R VI++ P D+E Y IGR GR G
Sbjct: 482 LHQFRSGKSPILVATAVAARGLDISNVRHVINFDLPSDIEEYVHRIGRTGRVGNLGLATS 541
Query: 867 LWAPADINLNRHLLTEIRNEKFRLYK-LKMMAKMEKYLHSSRCR 909
+ ++N+ + LL + K + L+ MA Y SR R
Sbjct: 542 FFNEKNMNITKDLLDLLVEAKQEVPSWLENMAYEHHYKGGSRGR 585
>gi|13514809 DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
[Homo sapiens]
Length = 660
Score = 56.2 bits (134), Expect = 2e-07
Identities = 91/404 (22%), Positives = 157/404 (38%), Gaps = 66/404 (16%)
Query: 551 PVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYP---PVYVG------------------ 589
PVQ I +++ +RD +A TG GK+ F P +Y
Sbjct: 203 PVQKHAI-PIIKGKRDLMACAQTGSGKTAAFLLPILSQIYTDGPGEALKAVKENGRYGRR 261
Query: 590 ---KIGLVISPLISLM-----EDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYV 641
I LV++P L E + + P G A + D++ G + +V
Sbjct: 262 KQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVVYGGADIGQQIRDLERGCHLLV-A 320
Query: 642 TPEYCSGNMGLLQQLE-ADIGITL---IAVDEAHCISEWGHDFRDSFRKLGSLKTALPMV 697
TP L+ +E IG+ + +DEA + + G F R++ T P
Sbjct: 321 TPGR------LVDMMERGKIGLDFCKYLVLDEADRMLDMG--FEPQIRRIVEQDTMPPKG 372
Query: 698 PIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRR---KTGNILQ------ 748
V T S++ ++I Q+ F ++L V R + NI Q
Sbjct: 373 --VRHTMMFSATFPKEI---------QMLARDFLDEYIFLAVGRVGSTSENITQKVVWVE 421
Query: 749 --DLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDI 806
D + FL+ + T+++ ++K + L +C + H S R++
Sbjct: 422 DLDKRSFLLDILGATGSDSLTLVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDREEA 481
Query: 807 HHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHV 866
H+F + ++AT G++ +++R VI++ P D+E Y IGR GR G
Sbjct: 482 LHQFRSGKSPILVATAVAARGLDISNVRHVINFDLPSDIEEYVHRIGRTGRVGNLGLATS 541
Query: 867 LWAPADINLNRHLLTEIRNEKFRLYK-LKMMAKMEKYLHSSRCR 909
+ ++N+ + LL + K + L+ MA Y SR R
Sbjct: 542 FFNEKNMNITKDLLDLLVEAKQEVPSWLENMAYEHHYKGGSRGR 585
>gi|45446747 DEAD box polypeptide 42 protein [Homo sapiens]
Length = 938
Score = 55.8 bits (133), Expect = 3e-07
Identities = 33/144 (22%), Positives = 64/144 (44%), Gaps = 1/144 (0%)
Query: 765 GPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAF 824
G +++ + +++ L++ + G H M S R + F + +I ++AT
Sbjct: 499 GSVLLFVTKKANAEELANNLKQEGHNLGLLHGDMDQSERNKVISDFKKKDIPVLVATDVA 558
Query: 825 GMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIR 884
G++ I+ VI+Y +D++++ IGR GR G + + L P D N L+ +
Sbjct: 559 ARGLDIPSIKTVINYDVARDIDTHTHRIGRTGRAGEKGVAYTLLTPKDSNFAGDLVRNLE 618
Query: 885 NEKFRLYK-LKMMAKMEKYLHSSR 907
+ K L +A + SR
Sbjct: 619 GANQHVSKELLDLAMQNAWFRKSR 642
>gi|45446743 DEAD box polypeptide 42 protein [Homo sapiens]
Length = 938
Score = 55.8 bits (133), Expect = 3e-07
Identities = 33/144 (22%), Positives = 64/144 (44%), Gaps = 1/144 (0%)
Query: 765 GPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAF 824
G +++ + +++ L++ + G H M S R + F + +I ++AT
Sbjct: 499 GSVLLFVTKKANAEELANNLKQEGHNLGLLHGDMDQSERNKVISDFKKKDIPVLVATDVA 558
Query: 825 GMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIR 884
G++ I+ VI+Y +D++++ IGR GR G + + L P D N L+ +
Sbjct: 559 ARGLDIPSIKTVINYDVARDIDTHTHRIGRTGRAGEKGVAYTLLTPKDSNFAGDLVRNLE 618
Query: 885 NEKFRLYK-LKMMAKMEKYLHSSR 907
+ K L +A + SR
Sbjct: 619 GANQHVSKELLDLAMQNAWFRKSR 642
>gi|13129006 nucleolar protein GU2 [Homo sapiens]
Length = 737
Score = 55.5 bits (132), Expect = 4e-07
Identities = 120/518 (23%), Positives = 198/518 (38%), Gaps = 71/518 (13%)
Query: 396 DITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPN 455
DI E E + E +SQ++ + + H +D +++T +D DL+ K
Sbjct: 9 DIMELEAPLEESESQKKERQKSDRRKSRHHYDSDEKSETRENGVTD-DLDAPKAKKSKMK 67
Query: 456 DNEN-DTSYVIESDEDLEMEMLKS----LENLNSGTVEPTHSKCLKMERNLGLPTKEEEE 510
+ N DT E L E KS ++L +G ++ K ++ +L T + +
Sbjct: 68 EKLNGDTE---EGFNRLSDEFSKSHKSRRKDLPNGDIDEYEKKSKRVS-SLDTSTHKSSD 123
Query: 511 DDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAV 570
+ E E+ + +P +EE + LK G + P+Q K V E + D +A
Sbjct: 124 NKLEETLTREQKEGAFSNFPI-SEETIKLLKGR-GVTYLFPIQVKTFGPVYEGK-DLIAQ 180
Query: 571 MATGYGKSLCFQYPPVYVGKIG------------LVISPLISLMEDQVLQLK---MSNIP 615
TG GK+ F P + + LV++P L K
Sbjct: 181 ARTGTGKTFSFAIPLIERLQRNQETIKKSRSPKVLVLAPTRELANQVAKDFKDITRKLSV 240
Query: 616 ACFLGSAQSENVLTDIKLGKYRIVYVTP-----EYCSGNMGL-------LQQLEA--DIG 661
ACF G ++ + I+ G I+ TP SG + L L +++ D+G
Sbjct: 241 ACFYGGTSYQSQINHIRNG-IDILVGTPGRIKDHLQSGRLDLSKLRHVVLDEVDQMLDLG 299
Query: 662 ITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIV------ 715
D H + D D+ + L T V VA S + D+V
Sbjct: 300 FAEQVEDIIH--ESYKTDSEDNPQTLLFSATCPQWVYKVAKKYMKSRYEQVDLVGKMTQK 357
Query: 716 RCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRK 775
+ + I C RP + G++LQ V + S EG II+C ++K
Sbjct: 358 AATTVEHLAIQCHWSQRPAVI-------GDVLQ------VYSGS----EGRAIIFCETKK 400
Query: 776 -MTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIR 834
+T+ K N C H ++ S R+ F + ++AT G++ ++
Sbjct: 401 NVTEMAMNPHIKQNAQC--LHGDIAQSQREITLKGFREGSFKVLVATNVAARGLDIPEVD 458
Query: 835 QVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPAD 872
VI P+D+ESY GR GR G C + P +
Sbjct: 459 LVIQSSPPQDVESYIHRSGRTGRAGRTGICICFYQPRE 496
>gi|7661920 eukaryotic translation initiation factor 4A, isoform 3
[Homo sapiens]
Length = 411
Score = 55.1 bits (131), Expect = 5e-07
Identities = 41/172 (23%), Positives = 77/172 (44%), Gaps = 16/172 (9%)
Query: 695 PMVPIVALTATASSSIRE-------DIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNIL 747
P +V ++AT I E D +R L ++ ++T G + + +E + L
Sbjct: 210 PATQVVLISATLPHEILEMTNKFMTDPIRIL-VKRDELTLEGIKQFFVAVEREEWKFDTL 268
Query: 748 QDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIH 807
DL L T + +I+C +++ +T ++R+ N + + H M R+ I
Sbjct: 269 CDLYDTLTITQA--------VIFCNTKRKVDWLTEKMREANFTVSSMHGDMPQKERESIM 320
Query: 808 HRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDG 859
F + +I+T + G++ + +I+Y P + E Y IGR+GR G
Sbjct: 321 KEFRSGASRVLISTDVWARGLDVPQVSLIINYDLPNNRELYIHRIGRSGRYG 372
>gi|4758138 DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 [Homo sapiens]
Length = 614
Score = 54.7 bits (130), Expect = 6e-07
Identities = 77/344 (22%), Positives = 135/344 (39%), Gaps = 40/344 (11%)
Query: 566 DNVAVMATGYGKSLCFQYPPVYV-----------GKIGLVISPLISLMEDQVLQLKMSNI 614
D V V TG GK+L + P + G I LV++P L + QV Q+
Sbjct: 133 DMVGVAQTGSGKTLSYLLPAIVHINHQPFLERGDGPICLVLAPTRELAQ-QVQQVAAEYC 191
Query: 615 PACFL------GSAQSENVLTDIKLGKYRIVYVTPEYCSGNMG-LLQQLEADIG----IT 663
AC L G A + D++ G E C G L+ LE T
Sbjct: 192 RACRLKSTCIYGGAPKGPQIRDLERGV--------EICIATPGRLIDFLECGKTNLRRTT 243
Query: 664 LIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIR---EDIVRCLNL 720
+ +DEA + + G F RK+ + P + +AT +R ED ++ +
Sbjct: 244 YLVLDEADRMLDMG--FEPQIRKI--VDQIRPDRQTLMWSATWPKEVRQLAEDFLK--DY 297
Query: 721 RNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQV 780
+ I + L++ ++ +D + + E E TI++ +++ ++
Sbjct: 298 IHINIGALELSANHNILQIVDVCHDVEKDEKLIRLMEEIMSEKENKTIVFVETKRRCDEL 357
Query: 781 TGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYG 840
T ++R+ H S R + + F + +IAT G++ D++ VI+Y
Sbjct: 358 TRKMRRDGWPAMGIHGDKSQQERDWVLNEFKHGKAPILIATDVASRGLDVEDVKFVINYD 417
Query: 841 APKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIR 884
P E Y IGR R + + + P +I L++ +R
Sbjct: 418 YPNSSEDYIHRIGRTARSTKTGTAYTFFTPNNIKQVSDLISVLR 461
>gi|222352149 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 [Homo
sapiens]
Length = 648
Score = 52.4 bits (124), Expect = 3e-06
Identities = 73/327 (22%), Positives = 125/327 (38%), Gaps = 58/327 (17%)
Query: 566 DNVAVMATGYGKSLCFQYPPVYVGKIGLVISP----------LISLMEDQVLQLKMSNI- 614
D + V TG GK+LC+ P G I LV+ P ++ L + L L++
Sbjct: 281 DLIGVAQTGTGKTLCYLMP----GFIHLVLQPSLKGQRNRPGMLVLTPTRELALQVEGEC 336
Query: 615 ---------PACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADI----- 660
C G + + ++K G I+ TP G L L+
Sbjct: 337 CKYSYKGLRSVCVYGGGNRDEQIEELKKG-VDIIIATP-------GRLNDLQMSNFVNLK 388
Query: 661 GITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNL 720
IT + +DEA + + G F K+ L P V +AT S+ + L
Sbjct: 389 NITYLVLDEADKMLDMG--FEPQIMKI--LLDVRPDRQTVMTSATWPHSVHR--LAQSYL 442
Query: 721 RNPQITCTGF--------DRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCP 772
+ P I G + N+ + + + +Q FL SS I++
Sbjct: 443 KEPMIVYVGTLDLVAVSSVKQNIIVTTEEEKWS---HMQTFLQSMSS----TDKVIVFVS 495
Query: 773 SRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKAD 832
+ + ++ +L N+S + H R+ F +++ +IAT G++ D
Sbjct: 496 RKAVADHLSSDLILGNISVESLHGDREQRDREKALENFKTGKVRILIATDLASRGLDVHD 555
Query: 833 IRQVIHYGAPKDMESYYQEIGRAGRDG 859
+ V ++ P+++E Y IGR GR G
Sbjct: 556 VTHVYNFDFPRNIEEYVHRIGRTGRAG 582
>gi|38569503 ATP-dependent RNA helicase ROK1 isoform b [Homo
sapiens]
Length = 491
Score = 52.0 bits (123), Expect = 4e-06
Identities = 86/358 (24%), Positives = 137/358 (38%), Gaps = 39/358 (10%)
Query: 551 PVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYP-------PVYVGKIGLVISPLISLME 603
P+Q + I V+ R+ +A TG GK+L F P P G L+ISP L
Sbjct: 82 PIQMQAI-PVMLHGRELLASAPTGSGKTLAFSIPILMQLKQPANKGFRALIISPTRELAS 140
Query: 604 DQVLQLKMSNIPACFLGSAQSENVLTDIKLG-----KYRIVYVTPEYCSGNMGLLQQLEA 658
+L + F + + K G K+ I+ TP + LL+Q
Sbjct: 141 QIHRELIKISEGTGFRIHMIHKAAVAAKKFGPKSSKKFDILVTTPNRL---IYLLKQDPP 197
Query: 659 DIGITLI---AVDEAHCISEWGHD-FRDSFRKLGSLKTALPMVPIVALTATASSSIREDI 714
I + + VDE+ + E G FRD +L S+ A + A S++ D+
Sbjct: 198 GIDLASVEWLVVDESDKLFEDGKTGFRD---QLASIFLACTSHKV--RRAMFSATFAYDV 252
Query: 715 VRCLNLRNPQITCTGFDRPNLYLE--------VRRKTGNILQDLQPFLVKTSSHWEFEGP 766
+ L + N +E V +TG +L + LVK F P
Sbjct: 253 EQWCKLNLDNVISVSIGARNSAVETVEQELLFVGSETGKLLAMRE--LVKKG----FNPP 306
Query: 767 TIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGM 826
+++ S + +++ EL ++ HA + R + H F +I +I T
Sbjct: 307 VLVFVQSIERAKELFHELIYEGINVDVIHAERTQQQRDNTVHSFRAGKIWVLICTALLAR 366
Query: 827 GINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIR 884
GI+ + VI+Y P Y IGR GR G + + D L R + I+
Sbjct: 367 GIDFKGVNLVINYDFPTSSVEYIHRIGRTGRAGNKGKAITFFTEDDKPLLRSVANVIQ 424
>gi|38569505 ATP-dependent RNA helicase ROK1 isoform a [Homo
sapiens]
Length = 599
Score = 52.0 bits (123), Expect = 4e-06
Identities = 86/358 (24%), Positives = 137/358 (38%), Gaps = 39/358 (10%)
Query: 551 PVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYP-------PVYVGKIGLVISPLISLME 603
P+Q + I V+ R+ +A TG GK+L F P P G L+ISP L
Sbjct: 190 PIQMQAI-PVMLHGRELLASAPTGSGKTLAFSIPILMQLKQPANKGFRALIISPTRELAS 248
Query: 604 DQVLQLKMSNIPACFLGSAQSENVLTDIKLG-----KYRIVYVTPEYCSGNMGLLQQLEA 658
+L + F + + K G K+ I+ TP + LL+Q
Sbjct: 249 QIHRELIKISEGTGFRIHMIHKAAVAAKKFGPKSSKKFDILVTTPNRL---IYLLKQDPP 305
Query: 659 DIGITLI---AVDEAHCISEWGHD-FRDSFRKLGSLKTALPMVPIVALTATASSSIREDI 714
I + + VDE+ + E G FRD +L S+ A + A S++ D+
Sbjct: 306 GIDLASVEWLVVDESDKLFEDGKTGFRD---QLASIFLACTSHKV--RRAMFSATFAYDV 360
Query: 715 VRCLNLRNPQITCTGFDRPNLYLE--------VRRKTGNILQDLQPFLVKTSSHWEFEGP 766
+ L + N +E V +TG +L + LVK F P
Sbjct: 361 EQWCKLNLDNVISVSIGARNSAVETVEQELLFVGSETGKLLAMRE--LVKKG----FNPP 414
Query: 767 TIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGM 826
+++ S + +++ EL ++ HA + R + H F +I +I T
Sbjct: 415 VLVFVQSIERAKELFHELIYEGINVDVIHAERTQQQRDNTVHSFRAGKIWVLICTALLAR 474
Query: 827 GINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIR 884
GI+ + VI+Y P Y IGR GR G + + D L R + I+
Sbjct: 475 GIDFKGVNLVINYDFPTSSVEYIHRIGRTGRAGNKGKAITFFTEDDKPLLRSVANVIQ 532
>gi|164664518 DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 [Homo
sapiens]
Length = 483
Score = 51.6 bits (122), Expect = 5e-06
Identities = 29/93 (31%), Positives = 47/93 (50%)
Query: 767 TIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGM 826
+II+C S + + + ++ +L SC HA M R + H F + ++ T F
Sbjct: 337 SIIFCNSSQRVELLAKKISQLGYSCFYIHAKMRQEHRNRVFHDFRNGLCRNLVCTDLFTR 396
Query: 827 GINKADIRQVIHYGAPKDMESYYQEIGRAGRDG 859
GI+ + VI++ PK E+Y IGR+GR G
Sbjct: 397 GIDIQAVNVVINFDFPKLAETYLHRIGRSGRFG 429
>gi|188035877 DEAD (Asp-Glu-Ala-Asp) box polypeptide 59 [Homo
sapiens]
Length = 619
Score = 51.2 bits (121), Expect = 7e-06
Identities = 74/343 (21%), Positives = 144/343 (41%), Gaps = 52/343 (15%)
Query: 545 GHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKI------GLVISPL 598
G+ P+Q ++I L R D +A TG GK+ F P + L+++P
Sbjct: 222 GYEVPTPIQMQMIPVGLLGR-DILASADTGSGKTAAFLLPVIMRALFESKTPSALILTPT 280
Query: 599 ISL---MEDQVLQLKMSNIP----ACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMG 651
L +E Q +L MS +P +G L ++ +++ TP +
Sbjct: 281 RELAIQIERQAKEL-MSGLPRMKTVLLVGGLPLPPQLYRLQQ-HVKVIIATPGRL---LD 335
Query: 652 LLQQLEADI-GITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPM---VPIVALTATAS 707
+++Q ++ G+ ++ VDEA D+ K+G + L + +P T S
Sbjct: 336 IIKQSSVELCGVKIVVVDEA-----------DTMLKMGFQQQVLDILENIPNDCQTILVS 384
Query: 708 SSIREDIVRCLN--LRNP--------QITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKT 757
++I I + + L NP + C + L++E K + + L +
Sbjct: 385 ATIPTSIEQLASQLLHNPVRIITGEKNLPCANVRQIILWVEDPAKKKKLFEILNDKKL-- 442
Query: 758 SSHWEFEGPTIIYCPSRKMTQQVTGELRKLN-LSCGTYHAGMSFSTRKDIHHRFVRDEIQ 816
F+ P +++ + ++ ++K+ L + H+ S RK+I + + +
Sbjct: 443 -----FKPPVLVFVDCKLGADLLSEAVQKITGLKSISIHSEKSQIERKNILKGLLEGDYE 497
Query: 817 CVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDG 859
V++T G G++ +R V+++ P M+ Y +IGR GR G
Sbjct: 498 VVVSTGVLGRGLDLISVRLVVNFDMPSSMDEYVHQIGRVGRLG 540
>gi|4503529 eukaryotic translation initiation factor 4A isoform 1
[Homo sapiens]
Length = 406
Score = 50.4 bits (119), Expect = 1e-05
Identities = 53/209 (25%), Positives = 86/209 (41%), Gaps = 28/209 (13%)
Query: 662 ITLIAVDEAHCISEWGH--DFRDSFRKLGSLKTALPMVPIVALTATASSSIRE------- 712
I + +DEA + G D F+KL S +V L+AT S + E
Sbjct: 176 IKMFVLDEADEMLSRGFKDQIYDIFQKLNS------NTQVVLLSATMPSDVLEVTKKFMR 229
Query: 713 DIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNI--LQDLQPFLVKTSSHWEFEGPTIIY 770
D +R L ++ ++T G + Y+ V R+ + L DL L T + +I+
Sbjct: 230 DPIRIL-VKKEELTLEGIRQ--FYINVEREEWKLDTLCDLYETLTITQA--------VIF 278
Query: 771 CPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINK 830
+R+ +T ++ + + H M R I F + +I T GI+
Sbjct: 279 INTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDV 338
Query: 831 ADIRQVIHYGAPKDMESYYQEIGRAGRDG 859
+ VI+Y P + E+Y IGR GR G
Sbjct: 339 QQVSLVINYDLPTNRENYIHRIGRGGRFG 367
>gi|41327771 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 [Homo
sapiens]
Length = 820
Score = 50.1 bits (118), Expect = 2e-05
Identities = 28/97 (28%), Positives = 43/97 (44%)
Query: 763 FEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATI 822
F+ P II+ +K + L K+ + T H G R+ ++AT
Sbjct: 663 FDPPIIIFVNQKKGCDVLAKSLEKMGYNACTLHGGKGQEQREFALSNLKAGAKDILVATD 722
Query: 823 AFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDG 859
G GI+ D+ V++Y K++E Y IGR GR G
Sbjct: 723 VAGRGIDIQDVSMVVNYDMAKNIEDYIHRIGRTGRAG 759
>gi|9966805 DEAD (Asp-Glu-Ala-Asp) box polypeptide 24 [Homo sapiens]
Length = 859
Score = 49.7 bits (117), Expect = 2e-05
Identities = 41/161 (25%), Positives = 73/161 (45%), Gaps = 2/161 (1%)
Query: 762 EFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIAT 821
++ G ++++ S ++++G L+ L++ T HA M R +F R E ++AT
Sbjct: 585 QYPGRSLVFANSISCIKRLSGLLKVLDIMPLTLHACMHQKQRLRNLEQFARLEDCVLLAT 644
Query: 822 IAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPAD-INLNRHLL 880
G++ ++ VIHY P+ E Y GR R + +L P D IN +
Sbjct: 645 DVAARGLDIPKVQHVIHYQVPRTSEIYVHRSGRTARATNEGLSLMLIGPEDVINFKKIYK 704
Query: 881 TEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQ 921
T ++E L+ ++ M+ R RQI S + + Q
Sbjct: 705 TLKKDEDIPLFPVQ-TKYMDVVKERIRLARQIEKSEYRNFQ 744
Score = 34.7 bits (78), Expect = 0.68
Identities = 40/214 (18%), Positives = 81/214 (37%), Gaps = 10/214 (4%)
Query: 374 FEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNEND 433
FE+ + + + L S + + + Q + ++ +EE + K L + N
Sbjct: 50 FEELTDYQLVSPAKNPSSLFSKEAPKRKAQAVSEEEEEEEGKSSSPKKKIKLKKSKNVAT 109
Query: 434 TSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSK 493
+ + +++ L+ + +D + E+L K +N +EP+ S
Sbjct: 110 EGTSTQKEFEVKDPELEAQGDDMVCDDPEAGEMTSENLVQTAPKKKKNKGKKGLEPSQST 169
Query: 494 CLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQ 553
K+ P K + E + + KD P P V + G S+ P+Q
Sbjct: 170 AAKV------PKKAKTWIPEVHDQKADVSAWKDLFVPRP----VLRALSFLGFSAPTPIQ 219
Query: 554 WKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVY 587
+ + ++ D + TG GK+L F P ++
Sbjct: 220 ALTLAPAIRDKLDILGAAETGSGKTLAFAIPMIH 253
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.132 0.384
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 53,093,510
Number of Sequences: 37866
Number of extensions: 2417618
Number of successful extensions: 12533
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 101
Number of HSP's successfully gapped in prelim test: 199
Number of HSP's that attempted gapping in prelim test: 10867
Number of HSP's gapped (non-prelim): 1260
length of query: 1432
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1317
effective length of database: 13,892,928
effective search space: 18296986176
effective search space used: 18296986176
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.