Search of human proteins with 166295200

Search of human proteins with 166295200

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|166295200 cytochrome P450, family 7, subfamily A,
polypeptide 1 [Homo sapiens]
         (504 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|166295200 cytochrome P450, family 7, subfamily A, polypeptide...  1032   0.0  
gi|4758104 cytochrome P450, family 7, subfamily B, polypeptide 1...   349   3e-96
gi|166362724 cytochrome P450, family 8, subfamily B, polypeptide...   302   4e-82
gi|13699859 prostaglandin I2 (prostacyclin) synthase [Homo sapiens]   258   7e-69
gi|32313587 cytochrome P450, family 39, subfamily A, polypeptide...   121   2e-27
gi|4503243 cytochrome P450, family 51, subfamily A, polypeptide ...    85   2e-16
gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide...    81   2e-15
gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide ...    67   3e-11
gi|9845285 cytochrome P450, family 26, subfamily b, polypeptide ...    67   3e-11
gi|225903399 cytochrome P450, family 51, subfamily A, polypeptid...    66   8e-11
gi|61743918 cytochrome P450, family 11, subfamily B, polypeptide...    64   3e-10
gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7...    63   7e-10
gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11...    63   7e-10
gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11...    63   7e-10
gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide...    62   1e-09
gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5...    62   2e-09
gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide ...    60   5e-09
gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide ...    59   1e-08
gi|30023836 cytochrome P450 4Z1 [Homo sapiens]                         59   1e-08
gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide ...    57   3e-08
gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8...    57   5e-08
gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide ...    57   5e-08
gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1 ...    56   9e-08
gi|119829183 cytochrome P450, family 11, subfamily B, polypeptid...    56   9e-08
gi|13449277 cytochrome P450, family 2, subfamily S, polypeptide ...    55   1e-07
gi|29837648 cytochrome P450, family 4, subfamily X, polypeptide ...    55   1e-07
gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide ...    54   3e-07
gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide ...    54   3e-07
gi|167466231 cytochrome P450, family 27, subfamily C, polypeptid...    53   6e-07
gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide ...    53   7e-07

>gi|166295200 cytochrome P450, family 7, subfamily A, polypeptide 1
           [Homo sapiens]
          Length = 504

 Score = 1032 bits (2668), Expect = 0.0
 Identities = 504/504 (100%), Positives = 504/504 (100%)

Query: 1   MMTTSLIWGIAIAACCCLWLILGIRRRQTGEPPLENGLIPYLGCALQFGANPLEFLRANQ 60
           MMTTSLIWGIAIAACCCLWLILGIRRRQTGEPPLENGLIPYLGCALQFGANPLEFLRANQ
Sbjct: 1   MMTTSLIWGIAIAACCCLWLILGIRRRQTGEPPLENGLIPYLGCALQFGANPLEFLRANQ 60

Query: 61  RKHGHVFTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDGN 120
           RKHGHVFTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDGN
Sbjct: 61  RKHGHVFTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDGN 120

Query: 121 TTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMF 180
           TTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMF
Sbjct: 121 TTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMF 180

Query: 181 EAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAE 240
           EAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAE
Sbjct: 181 EAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAE 240

Query: 241 SLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQ 300
           SLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQ
Sbjct: 241 SLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQ 300

Query: 301 MIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSAS 360
           MIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSAS
Sbjct: 301 MIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSAS 360

Query: 361 LNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTK 420
           LNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTK
Sbjct: 361 LNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTK 420

Query: 421 TTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLD 480
           TTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLD
Sbjct: 421 TTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLD 480

Query: 481 QSRAGLGILPPLNDIEFKYKFKHL 504
           QSRAGLGILPPLNDIEFKYKFKHL
Sbjct: 481 QSRAGLGILPPLNDIEFKYKFKHL 504


>gi|4758104 cytochrome P450, family 7, subfamily B, polypeptide 1
           [Homo sapiens]
          Length = 506

 Score =  349 bits (896), Expect = 3e-96
 Identities = 205/499 (41%), Positives = 299/499 (59%), Gaps = 19/499 (3%)

Query: 9   GIAIAACCCLW-LILGIRR-RQTGEPPLENGLIPYLGCALQFGANPLEFLRANQRKHGHV 66
           G+A+AA   L  L L +RR R+ GEPPL  G +PYLG  L    +PL F++  Q++HG  
Sbjct: 21  GLALAAALLLLALCLLVRRTRRPGEPPLIKGWLPYLGVVLNLRKDPLRFMKTLQKQHGDT 80

Query: 67  FTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDGNTTENIN 126
           FT  L GKY+ FI +P  Y  V+ + K   ++ F      KAF   SI  +  N   ++N
Sbjct: 81  FTVLLGGKYITFILDPFQYQLVIKNHKQLSFRVFSNKLLEKAF---SISQLQKN--HDMN 135

Query: 127 DTF---IKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAG 183
           D      + LQG +L+ L ESMM+NL+++  P +    KT +W T  +Y FC  ++FE  
Sbjct: 136 DELHLCYQFLQGKSLDILLESMMQNLKQVFEPQLL---KTTSWDTAELYPFCSSIIFEIT 192

Query: 184 YLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLR 243
           + TI+G+ +   + +    L   D+F +FD  F  LV+ +PI +     + REK+ +   
Sbjct: 193 FTTIYGKVIVCDNNKFISELR--DDFLKFDDKFAYLVSNIPIELLGNVKSIREKIIKCFS 250

Query: 244 HENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIR 303
            E L K +  SE+   R  + +     +DLE    HL  LWAS ANTIP  FW+++ ++R
Sbjct: 251 SEKLAKMQGWSEVFQSRQDVLEKYYVHEDLEIGAHHLGFLWASVANTIPTMFWAMYYLLR 310

Query: 304 NPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNI 363
           +PEAM A  +E+ R L++ GQK    G PI L++ +L+ L  L+S I E+LRLSS S  I
Sbjct: 311 HPEAMAAVRDEIDRLLQSTGQKKG-SGFPIHLTREQLDSLICLESSIFEALRLSSYSTTI 369

Query: 364 RTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTF 423
           R  +ED TL  E G Y +RK D++A++P ++H DPEI+  P  F+YDR++ E+GK KTTF
Sbjct: 370 RFVEEDLTLSSETGDYCVRKGDLVAIFPPVLHGDPEIFEAPEEFRYDRFI-EDGKKKTTF 428

Query: 424 YCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSR 483
           +  G KLK Y MPFG+G + CPGR FA+ EIKQ L+++L+YF+LE+I+   K   L+ SR
Sbjct: 429 FKRGKKLKCYLMPFGTGTSKCPGRFFALMEIKQLLVILLTYFDLEIIDD--KPIGLNYSR 486

Query: 484 AGLGILPPLNDIEFKYKFK 502
              GI  P +D+ F+YK K
Sbjct: 487 LLFGIQYPDSDVLFRYKVK 505


>gi|166362724 cytochrome P450, family 8, subfamily B, polypeptide 1
           [Homo sapiens]
          Length = 501

 Score =  302 bits (774), Expect = 4e-82
 Identities = 178/509 (34%), Positives = 284/509 (55%), Gaps = 28/509 (5%)

Query: 6   LIWG-------IAIAACCCLWLILGIRRRQTGEPPLENGLIPYLGCALQFGANPLEFLRA 58
           ++WG       + IA   CL  +L  R+R+  EPPL+ G +P+LG A+ F  N  EFL+ 
Sbjct: 2   VLWGPVLGALLVVIAGYLCLPGML--RQRRPWEPPLDKGTVPWLGHAMAFRKNMFEFLKR 59

Query: 59  NQRKHGHVFTCKLMGKYVHFITNPLSYHKVLCHG-KYFDWKKFHFATSAKAFGHRSIDPM 117
            + KHG VFT +L G+Y  F+ +PLS+  +L    +  D+ ++      K FG+RS+   
Sbjct: 60  MRTKHGDVFTVQLGGQYFTFVMDPLSFGSILKDTQRKLDFGQYAKKLVLKVFGYRSVQ-- 117

Query: 118 DGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYR 177
                E I+    K L+G  L  L E+M+++L  +M      +   + W  + ++ FCY 
Sbjct: 118 --GDHEMIHSASTKHLRGDGLKDLNETMLDSLSFVMLTSKGWSLDASCWHEDSLFRFCYY 175

Query: 178 VMFEAGYLTIFGRDLTR-RDTQKAHILNNLDNFKQFDKVFPALVAGL--PIHMFRTAHNA 234
           ++F AGYL++FG    + +D  +A  L     F++FD +FP  V  L  P          
Sbjct: 176 ILFTAGYLSLFGYTKDKEQDLLQAGEL--FMEFRKFDLLFPRFVYSLLWPREWLEVGRLQ 233

Query: 235 REKLAESLRHENLQKRESISELI-SLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPA 293
           R    + L   + Q++E IS  + ++  FL +         + K + ++LWASQ NT P 
Sbjct: 234 R-LFHKMLSVSHSQEKEGISNWLGNMLQFLRE--QGVPSAMQDKFNFMMLWASQGNTGPT 290

Query: 294 TFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKES 353
           +FW+L  ++++PEA++A  EE  + L  A  +              L   PVLDS+++E+
Sbjct: 291 SFWALLYLLKHPEAIRAVREEATQVLGEARLETK---QSFAFKLGALQHTPVLDSVVEET 347

Query: 354 LRLSSASLNIRTAKEDFTLHLEDGS-YNIRKDDIIALYPQL-MHLDPEIYPDPLTFKYDR 411
           LRL +A   +R   ED+TL +  G  Y  R  DI+AL+P L +H+DP+I+P+P  FKYDR
Sbjct: 348 LRLRAAPTLLRLVHEDYTLKMSSGQEYLFRHGDILALFPYLSVHMDPDIHPEPTVFKYDR 407

Query: 412 YLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIE 471
           +L+ NG  K  F+  G K+ +Y MP+GSG +ICPGR FA+ E+K F++LM+++F+LEL++
Sbjct: 408 FLNPNGSRKVDFFKTGKKIHHYTMPWGSGVSICPGRFFALSEVKLFILLMVTHFDLELVD 467

Query: 472 GQAKCPPLDQSRAGLGILPPLNDIEFKYK 500
                P +D  R G G + P +D+ F+Y+
Sbjct: 468 PDTPLPHVDPQRWGFGTMQPSHDVRFRYR 496


>gi|13699859 prostaglandin I2 (prostacyclin) synthase [Homo sapiens]
          Length = 500

 Score =  258 bits (660), Expect = 7e-69
 Identities = 166/509 (32%), Positives = 264/509 (51%), Gaps = 22/509 (4%)

Query: 6   LIWGIAIAACCCLWLILGIRRRQT---GEPPLENGLIPYLGCALQFGANPLEFLRANQRK 62
           + W   +     L L+L + RR+T   GEPPL+ G IP+LG AL FG +   FL   + K
Sbjct: 1   MAWAALLGLLAALLLLLLLSRRRTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEK 60

Query: 63  HGHVFTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDGNTT 122
           HG +FT  + G+YV  + +P SY  V+   +     +  F   A     R  D    + +
Sbjct: 61  HGDIFTILVGGRYVTVLLDPHSYDAVVWEPR----TRLDFHAYAIFLMERIFDVQLPHYS 116

Query: 123 ENINDTFIK-TLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFE 181
            +     +K TL    L +LTE+M  NL  ++    +     + W   G+  F Y  +  
Sbjct: 117 PSDEKARMKLTLLHRELQALTEAMYTNLHAVLLGDATEAG--SGWHEMGLLDFSYSFLLR 174

Query: 182 AGYLTIFGRDLTRRDTQ-----KAHILNNLDNFKQFDKVFPALVAG-LPIHMFRTAHNAR 235
           AGYLT++G +   R  +     + H  +    F+Q D++ P L  G L +       + +
Sbjct: 175 AGYLTLYGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVK 234

Query: 236 EKLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATF 295
            +L + L    L +R   S+ +   +   + +   ++++ A+  ++ LWA+Q N  PA F
Sbjct: 235 SRLWKLLSPARLARRAHRSKWLESYLLHLEEMGVSEEMQ-ARALVLQLWATQGNMGPAAF 293

Query: 296 WSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLR 355
           W L  +++NPEA+ A   E++  L  A Q VS       L Q  L+  PVLDS++ ESLR
Sbjct: 294 WLLLFLLKNPEALAAVRGELESILWQAEQPVS---QTTTLPQKVLDSTPVLDSVLSESLR 350

Query: 356 LSSASLNIRTAKEDFTLHLEDG-SYNIRKDDIIALYPQLM-HLDPEIYPDPLTFKYDRYL 413
           L++A    R    D  + + DG  +N+R+ D + L+P L    DPEIY DP  FKY+R+L
Sbjct: 351 LTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFL 410

Query: 414 DENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQ 473
           + +G  K  FY +G +LK Y MP+G+G   C GR +A++ IKQF+ L+L + +LELI   
Sbjct: 411 NPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINAD 470

Query: 474 AKCPPLDQSRAGLGILPPLNDIEFKYKFK 502
            + P  D SR G G++ P +D+  +Y+ +
Sbjct: 471 VEIPEFDLSRYGFGLMQPEHDVPVRYRIR 499


>gi|32313587 cytochrome P450, family 39, subfamily A, polypeptide 1
           [Homo sapiens]
          Length = 469

 Score =  121 bits (303), Expect = 2e-27
 Identities = 117/497 (23%), Positives = 214/497 (43%), Gaps = 57/497 (11%)

Query: 17  CLWLILGIRRRQTGEPPLENGLIPYLGCALQFGANPLEFLRANQRKHGHVFTCKLMGKYV 76
           CL L L ++R+    PP   G IP++G   +FG  PLEF+   + K+G +FT   MG  +
Sbjct: 14  CLALFLLLQRKNLRRPPCIKGWIPWIGVGFEFGKAPLEFIEKARIKYGPIFTVFAMGNRM 73

Query: 77  HFITNPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDGNTTENINDTFIKTLQGH 136
            F+T     +  L        KK  F  + +   +R+   +  N    +++     L+G 
Sbjct: 74  TFVTEEEGINVFLKS------KKVDFELAVQNIVYRTAS-IPKNVFLALHEKLYIMLKGK 126

Query: 137 A--------LNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIF 188
                       LTE + E L+ +               T  + +    +++      +F
Sbjct: 127 MGTVNLHQFTGQLTEELHEQLENL-----------GTHGTMDLNNLVRHLLYPVTVNMLF 175

Query: 189 GRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHENLQ 248
            + L    T K  I      F+ +D+ F    + LP  + R    +++   E L  +N+ 
Sbjct: 176 NKSLF--STNKKKIKEFHQYFQVYDEDFE-YGSQLPECLLRNWSKSKKWFLE-LFEKNIP 231

Query: 249 KRESISELISLRMFLNDTLSTFDDLEKAKTH-----LVVLWASQANTIPATFWSLFQMIR 303
             ++        M L        + E +K +     L++LWAS +N +P  FW+L  ++ 
Sbjct: 232 DIKACKSAKDNSMTLLQATLDIVETETSKENSPNYGLLLLWASLSNAVPVAFWTLAYVLS 291

Query: 304 NPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNI 363
           +P+  KA  E +      AG+      + I +S+ +L +L ++   + E++RL +  +  
Sbjct: 292 HPDIHKAIMEGISSVFGKAGK------DKIKVSEDDLENLLLIKWCVLETIRLKAPGVIT 345

Query: 364 RTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTF 423
           R   +     +E  +Y I   D++ L P  +H +P+ +P+P  FK +R+   N +  +  
Sbjct: 346 RKVVKP----VEILNYIIPSGDLLMLSPFWLHRNPKYFPEPELFKPERWKKANLEKHSFL 401

Query: 424 YCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSR 483
            C        +M FGSG   CP R FA+ E++  +IL+L  ++  L++   K   L    
Sbjct: 402 DC--------FMAFGSGKFQCPARWFALLEVQMCIILILYKYDCSLLDPLPKQSYLHL-- 451

Query: 484 AGLGILPPLNDIEFKYK 500
             +G+  P      +YK
Sbjct: 452 --VGVPQPEGQCRIEYK 466


>gi|4503243 cytochrome P450, family 51, subfamily A, polypeptide 1
           isoform 1 [Homo sapiens]
          Length = 509

 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 122/485 (25%), Positives = 200/485 (41%), Gaps = 59/485 (12%)

Query: 3   TTSLIWGIAIAACCCLWLILGIRRRQTGEPPLENGLIPYLGCALQFGANPLEFLRANQRK 62
           T SL++ I +AA   + L  G++      PP     IP+LG A+ FG +P+EFL     K
Sbjct: 43  TLSLVYLIRLAAGHLVQLPAGVK-----SPPYIFSPIPFLGHAIAFGKSPIEFLENAYEK 97

Query: 63  HGHVFTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDGNTT 122
           +G VF+  ++GK   ++        +L + K  D        +A+    R   P+ G   
Sbjct: 98  YGPVFSFTMVGKTFTYLLGS-DAAALLFNSKNED-------LNAEDVYSRLTTPVFGKGV 149

Query: 123 --ENINDTFI--KTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRV 178
             +  N  F+  K +    LN     +    Q +      +     +W   G  +  +  
Sbjct: 150 AYDVPNPVFLEQKKMLKSGLN-----IAHFKQHVSIIEKETKEYFESWGESGEKNV-FEA 203

Query: 179 MFEAGYLT----IFGRDLTRRDTQK-AHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHN 233
           + E   LT    + G+++  +  +K A +  +LD    F      L   LP+  FR    
Sbjct: 204 LSELIILTASHCLHGKEIRSQLNEKVAQLYADLDG--GFSHAAWLLPGWLPLPSFRRRDR 261

Query: 234 AREKLAESLRHENLQKRESISELIS--LRMFLNDTLST---FDDLEKAKTHLVVLWASQA 288
           A  ++ + + ++ +QKR    E I   L+  L+ T        D E A   + +L A Q 
Sbjct: 262 AHREIKD-IFYKAIQKRRQSQEKIDDILQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQH 320

Query: 289 NTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDS 348
            +   + W  F + R+    K    E         QK     N   L+  +L DL +LD 
Sbjct: 321 TSSTTSAWMGFFLARDKTLQKKCYLE---------QKTVCGENLPPLTYDQLKDLNLLDR 371

Query: 349 IIKESLRLSSA-SLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTF 407
            IKE+LRL     + +R A+   T+      Y I     + + P +     + + + L F
Sbjct: 372 CIKETLRLRPPIMIMMRMARTPQTV----AGYTIPPGHQVCVSPTVNQRLKDSWVERLDF 427

Query: 408 KYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFEL 467
             DRYL +N  +           K+ Y+PFG+G   C G  FA  +IK     ML  +E 
Sbjct: 428 NPDRYLQDNPASGE---------KFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEF 478

Query: 468 ELIEG 472
           +LI+G
Sbjct: 479 DLIDG 483


>gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide 2
           [Homo sapiens]
          Length = 525

 Score = 81.3 bits (199), Expect = 2e-15
 Identities = 72/254 (28%), Positives = 107/254 (42%), Gaps = 45/254 (17%)

Query: 260 RMFLNDTLSTFDDLEKAKTHLVV-------LWASQANTIPATFWSLFQMIRNPEAMKAAT 312
           R FL+  LS  DD     +H  +       ++     T  A  WSL+ +  NPE  K   
Sbjct: 297 RAFLDLLLSVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVD 356

Query: 313 EEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRL-SSASLNIRTAKEDFT 371
            E+      + +  ++E         +L  L  L+ +IKE+LRL  S  L  R+  ED  
Sbjct: 357 HELDDVFGKSDRPATVE---------DLKKLRYLECVIKETLRLFPSVPLFARSVSED-- 405

Query: 372 LHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLK 431
              E   Y + K     + P  +H DP  +P+P  F+ +R+  EN + +           
Sbjct: 406 --CEVAGYRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENAQGRH---------P 454

Query: 432 YYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGLG---- 487
           Y Y+PF +G   C G+ FA+ E K  L  +L +F +E           +Q R  LG    
Sbjct: 455 YAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHFWIE----------SNQKREELGLEGQ 504

Query: 488 -ILPPLNDIEFKYK 500
            IL P N I  K K
Sbjct: 505 LILRPSNGIWIKLK 518


>gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide 1
           [Homo sapiens]
          Length = 508

 Score = 67.4 bits (163), Expect = 3e-11
 Identities = 55/184 (29%), Positives = 86/184 (46%), Gaps = 23/184 (12%)

Query: 296 WSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLR 355
           W+L+++ R+PE   A   E+   L          G+    S   L+ LP+L +++KE LR
Sbjct: 328 WALYELSRHPEVQTALHSEITAALS--------PGSSAYPSATVLSQLPLLKAVVKEVLR 379

Query: 356 LSSASL-NIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLD 414
           L      N R   +D  +H+  G Y I K+ ++ L       DP  +P+P +F+  R+L 
Sbjct: 380 LYPVVPGNSRVPDKD--IHV--GDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLG 435

Query: 415 ENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQA 474
           E G T   F           +PFG G   C GR  A  E++  L  +L++FE++   G A
Sbjct: 436 E-GPTPHPFAS---------LPFGFGKRSCMGRRLAELELQMALAQILTHFEVQPEPGAA 485

Query: 475 KCPP 478
              P
Sbjct: 486 PVRP 489


>gi|9845285 cytochrome P450, family 26, subfamily b, polypeptide 1
           [Homo sapiens]
          Length = 512

 Score = 67.4 bits (163), Expect = 3e-11
 Identities = 96/429 (22%), Positives = 173/429 (40%), Gaps = 48/429 (11%)

Query: 55  FLRANQRKHGHVFTCKLMGKYVHFITNPLSYHKVLC---HGKYFDWKKFHFATSAKAFGH 111
           F  + + K+G+VF   L+G+ +  +T   +  K+L    H    +W +    ++    G 
Sbjct: 72  FQSSRREKYGNVFKTHLLGRPLIRVTGAENVRKILMGEHHLVSTEWPR----STRMLLGP 127

Query: 112 RSIDPMDGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGM 171
            ++    G+   N    F K     AL    ES +  +Q +++  + + S     +   +
Sbjct: 128 NTVSNSIGDIHRNKRKVFSKIFSHEAL----ESYLPKIQLVIQDTLRAWSSHPEAIN--V 181

Query: 172 YSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTA 231
           Y    ++ F      + G  +   D    H+      F   D VF +L   LP   +R  
Sbjct: 182 YQEAQKLTFRMAIRVLLGFSIPEEDL--GHLFEVYQQF--VDNVF-SLPVDLPFSGYRRG 236

Query: 232 HNAREKLAESLR---HENLQKRESISELISLRMFLNDTLS-----TFDDLEKAKTHLVVL 283
             AR+ L + L     E LQ  +    L +L + +  +       T  +L+     L+  
Sbjct: 237 IQARQILQKGLEKAIREKLQCTQGKDYLDALDLLIESSKEHGKEMTMQELKDGTLELI-- 294

Query: 284 WASQANTIPATFWSLFQMIRNPEAMKAATEEVKR--TLENAGQKVSLEGNPICLSQAELN 341
           +A+ A T  A+   + Q++++P  ++   +E++    L + G     EG    L    L+
Sbjct: 295 FAAYATTASASTSLIMQLLKHPTVLEKLRDELRAHGILHSGG--CPCEGT---LRLDTLS 349

Query: 342 DLPVLDSIIKESLRL-SSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEI 400
            L  LD +IKE +RL +  S   RT  + F L   DG + I K   +    +  H    +
Sbjct: 350 GLRYLDCVIKEVMRLFTPISGGYRTVLQTFEL---DG-FQIPKGWSVMYSIRDTHDTAPV 405

Query: 401 YPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLIL 460
           + D   F  DR+     + K          +++Y+PFG G   C G+  A   +K   + 
Sbjct: 406 FKDVNVFDPDRFSQARSEDKDG--------RFHYLPFGGGVRTCLGKHLAKLFLKVLAVE 457

Query: 461 MLSYFELEL 469
           + S    EL
Sbjct: 458 LASTSRFEL 466


>gi|225903399 cytochrome P450, family 51, subfamily A, polypeptide 1
           isoform 2 [Homo sapiens]
          Length = 404

 Score = 65.9 bits (159), Expect = 8e-11
 Identities = 70/256 (27%), Positives = 109/256 (42%), Gaps = 29/256 (11%)

Query: 223 LPIHMFRTAHNAREKLAESLRHENLQKRESISELIS--LRMFLNDTLST---FDDLEKAK 277
           LP+  FR    A  ++ + + ++ +QKR    E I   L+  L+ T        D E A 
Sbjct: 146 LPLPSFRRRDRAHREIKD-IFYKAIQKRRQSQEKIDDILQTLLDATYKDGRPLTDDEVAG 204

Query: 278 THLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQ 337
             + +L A Q  +   + W  F + R+    K    E         QK     N   L+ 
Sbjct: 205 MLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLE---------QKTVCGENLPPLTY 255

Query: 338 AELNDLPVLDSIIKESLRLSSA-SLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHL 396
            +L DL +LD  IKE+LRL     + +R A+   T+      Y I     + + P +   
Sbjct: 256 DQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTV----AGYTIPPGHQVCVSPTVNQR 311

Query: 397 DPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQ 456
             + + + L F  DRYL +N  +           K+ Y+PFG+G   C G  FA  +IK 
Sbjct: 312 LKDSWVERLDFNPDRYLQDNPASGE---------KFAYVPFGAGRHRCIGENFAYVQIKT 362

Query: 457 FLILMLSYFELELIEG 472
               ML  +E +LI+G
Sbjct: 363 IWSTMLRLYEFDLIDG 378


>gi|61743918 cytochrome P450, family 11, subfamily B, polypeptide 1
           isoform 1 precursor [Homo sapiens]
          Length = 503

 Score = 63.9 bits (154), Expect = 3e-10
 Identities = 61/245 (24%), Positives = 108/245 (44%), Gaps = 32/245 (13%)

Query: 227 MFRTAHNAREKLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWAS 286
           +F+   N  +K+ + L     Q+  SI       + LN  LS   D  KA + + +   S
Sbjct: 263 IFQYGDNCIQKIYQELAFSRPQQYTSIVA----ELLLNAELSP--DAIKANS-MELTAGS 315

Query: 287 QANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVL 346
              T+     +LF++ RNP   +A  +E      +     S+  +P    Q    +LP+L
Sbjct: 316 VDTTVFPLLMTLFELARNPNVQQALRQE------SLAAAASISEHP----QKATTELPLL 365

Query: 347 DSIIKESLRLSSASLNI-RTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPL 405
            + +KE+LRL    L + R A  D  L     +Y+I    ++ ++   +  +P ++P P 
Sbjct: 366 RAALKETLRLYPVGLFLERVASSDLVLQ----NYHIPAGTLVRVFLYSLGRNPALFPRPE 421

Query: 406 TFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYF 465
            +   R+LD  G  +           +Y++PFG G   C GR  A  E+   L  +L + 
Sbjct: 422 RYNPQRWLDIRGSGRN----------FYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHL 471

Query: 466 ELELI 470
           ++E +
Sbjct: 472 QVETL 476


>gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7
           [Homo sapiens]
          Length = 503

 Score = 62.8 bits (151), Expect = 7e-10
 Identities = 62/284 (21%), Positives = 115/284 (40%), Gaps = 34/284 (11%)

Query: 196 DTQKAHILNNLDNFKQFDKVFPAL--------VAGLPIHMFRTAHNAREKLAESLRHENL 247
           +T+K    N LD F    KVFP L        +   P  +      + +++ E    E  
Sbjct: 206 NTKKLLRFNPLDPFVLSIKVFPFLTPILEALNITVFPRKVISFLTKSVKQIKEGRLKETQ 265

Query: 248 QKRESISELI--SLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNP 305
           + R    +L+  S     ++T     DLE     ++ ++A    T     + ++++  +P
Sbjct: 266 KHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHP 325

Query: 306 EAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNI-R 364
           +  +   +E+   L N              +   +  L  LD ++ E+LRL   ++ + R
Sbjct: 326 DVQQKVQKEIDTVLPNKAPP----------TYDTVLQLEYLDMVVNETLRLFPVAMRLER 375

Query: 365 TAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFY 424
             K+D    +E     I K  ++ +   ++H DP+ + +P  F  +R+  +N        
Sbjct: 376 VCKKD----VEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDP-- 429

Query: 425 CNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELE 468
                  Y Y PFGSG   C G  FA+  +K  L+ +L  F  +
Sbjct: 430 -------YIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFK 466


>gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11
           [Homo sapiens]
          Length = 524

 Score = 62.8 bits (151), Expect = 7e-10
 Identities = 51/173 (29%), Positives = 81/173 (46%), Gaps = 21/173 (12%)

Query: 296 WSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLR 355
           W L+ + ++PE  +   +EV+  L++          PI +   +L  LP L   IKESLR
Sbjct: 339 WVLYHLAKHPEYQEQCRQEVQELLKDR--------EPIEIEWDDLAQLPFLTMCIKESLR 390

Query: 356 LSSASLNI-RTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLD 414
           L      I R   +DF L   DG   I K  +  +    +H +P ++PDP  +   R+  
Sbjct: 391 LHPPVPVISRCCTQDFVL--PDGRV-IPKGIVCLINIIGIHYNPTVWPDPEVYDPFRFDQ 447

Query: 415 ENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFEL 467
           EN K ++            ++PF +G   C G+ FA+ E+K  L L L +F +
Sbjct: 448 ENIKERSPLA---------FIPFSAGPRNCIGQAFAMAEMKVVLALTLLHFRI 491


>gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11
           [Homo sapiens]
          Length = 524

 Score = 62.8 bits (151), Expect = 7e-10
 Identities = 51/173 (29%), Positives = 81/173 (46%), Gaps = 21/173 (12%)

Query: 296 WSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLR 355
           W L+ + ++PE  +   +EV+  L++          PI +   +L  LP L   IKESLR
Sbjct: 339 WVLYHLAKHPEYQEQCRQEVQELLKDR--------EPIEIEWDDLAQLPFLTMCIKESLR 390

Query: 356 LSSASLNI-RTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLD 414
           L      I R   +DF L   DG   I K  +  +    +H +P ++PDP  +   R+  
Sbjct: 391 LHPPVPVISRCCTQDFVL--PDGRV-IPKGIVCLINIIGIHYNPTVWPDPEVYDPFRFDQ 447

Query: 415 ENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFEL 467
           EN K ++            ++PF +G   C G+ FA+ E+K  L L L +F +
Sbjct: 448 ENIKERSPLA---------FIPFSAGPRNCIGQAFAMAEMKVVLALTLLHFRI 491


>gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide 12
           [Homo sapiens]
          Length = 524

 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 58/216 (26%), Positives = 97/216 (44%), Gaps = 26/216 (12%)

Query: 283 LWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELND 342
           ++     T     W L+ + R+PE  +   +EV+  L++   K         +   +L  
Sbjct: 326 MFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKE--------IEWDDLAQ 377

Query: 343 LPVLDSIIKESLRLSSASLNI-RTAKEDFTLHLEDGSYNIRKDDIIALYPQL-MHLDPEI 400
           LP L   +KESLRL   +  I R   +D  L   DG   +    I  L   + +H +P +
Sbjct: 378 LPFLTMCVKESLRLHPPAPFISRCCTQDIVL--PDG--RVIPKGITCLIDIIGVHHNPTV 433

Query: 401 YPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLIL 460
           +PDP  +   R+  EN K ++            ++PF +G   C G+ FA+ E+K  L L
Sbjct: 434 WPDPEVYDPFRFDPENSKGRSPLA---------FIPFSAGPRNCIGQAFAMAEMKVVLAL 484

Query: 461 MLSYFEL--ELIEGQAKCPPLDQSRAGLGI-LPPLN 493
           ML +F    +  E + K   + ++  GL + + PLN
Sbjct: 485 MLLHFRFLPDHTEPRRKLELIMRAEGGLWLRVEPLN 520


>gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5
           [Homo sapiens]
          Length = 502

 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 45/198 (22%), Positives = 86/198 (43%), Gaps = 25/198 (12%)

Query: 272 DLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGN 331
           DLE A   ++ ++A    T     ++L+++  +P+  +   +E+   L N          
Sbjct: 292 DLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPP------ 345

Query: 332 PICLSQAELNDLPVLDSIIKESLRLSSASLNI-RTAKEDFTLHLEDGSYNIRKDDIIALY 390
               +   +  +  LD ++ E+LRL   ++ + RT K+D    +E     I K  ++ + 
Sbjct: 346 ----TYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKD----VEINGVFIPKGSMVVIP 397

Query: 391 PQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFA 450
              +H DP+ + +P  F+ +R+  +                Y Y PFG+G   C G  FA
Sbjct: 398 TYALHHDPKYWTEPEEFRPERFSKKKDSIDP----------YIYTPFGTGPRNCIGMRFA 447

Query: 451 IHEIKQFLILMLSYFELE 468
           +  +K  LI +L  F  +
Sbjct: 448 LMNMKLALIRVLQNFSFK 465


>gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide 4
           [Homo sapiens]
          Length = 503

 Score = 60.1 bits (144), Expect = 5e-09
 Identities = 62/284 (21%), Positives = 114/284 (40%), Gaps = 34/284 (11%)

Query: 196 DTQKAHILNNLDNFKQFDKVFPALVAGL--------PIHMFRTAHNAREKLAESLRHENL 247
           +T+K    + LD F     VFP L+  L        P  +      + +++ ES   +  
Sbjct: 206 NTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQ 265

Query: 248 QKRESISELISLRMFLNDTLS--TFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNP 305
           + R    +L+       +T S     DLE     ++ ++A    T     + ++++  +P
Sbjct: 266 KHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHP 325

Query: 306 EAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNI-R 364
           +  +   EE+   L N              +   +  +  LD ++ E+LRL   ++ + R
Sbjct: 326 DVQQKLQEEIDAVLPNKAPP----------TYDTVLQMEYLDMVVNETLRLFPIAMRLER 375

Query: 365 TAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFY 424
             K+D    +E     I K  ++ +    +H DP+ + +P  F  +R+  +N        
Sbjct: 376 VCKKD----VEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDP-- 429

Query: 425 CNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELE 468
                  Y Y PFGSG   C G  FA+  +K  LI +L  F  +
Sbjct: 430 -------YIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFK 466


>gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 2 [Homo sapiens]
          Length = 503

 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 66/303 (21%), Positives = 120/303 (39%), Gaps = 43/303 (14%)

Query: 186 TIFGRDLTRRDTQKAHILNNLDNFKQFD----------------KVFPALVAGL-PIHMF 228
           T+FG +L   +  +   L N+    + D                 VF AL  GL P  + 
Sbjct: 187 TLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVT 246

Query: 229 RTAHNAREKLAESLRHENLQKRESISELISLRMFLNDTLS--TFDDLEKAKTHLVVLWAS 286
               N+ E++ ES   +  + R    + +       +T S     DLE     +++++A+
Sbjct: 247 HFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAA 306

Query: 287 QANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVL 346
              T     + ++++  +P+  +   EE+   L N             ++   L  +  L
Sbjct: 307 YDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAP----------VTYDALVQMEYL 356

Query: 347 DSIIKESLRLSSASLNI-RTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPL 405
           D ++ E+LRL      + R  K+D    +E     I K   + +    +H DP+ + +P 
Sbjct: 357 DMVVNETLRLFPVVSRVTRVCKKD----IEINGVFIPKGLAVMVPIYALHHDPKYWTEPE 412

Query: 406 TFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYF 465
            F  +R+  +N  +            Y Y+PFG+G   C G  FA+  IK  +I  L  F
Sbjct: 413 KFCPERFSKKNKDSIDL---------YRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNF 463

Query: 466 ELE 468
             +
Sbjct: 464 SFK 466


>gi|30023836 cytochrome P450 4Z1 [Homo sapiens]
          Length = 505

 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 60/247 (24%), Positives = 104/247 (42%), Gaps = 28/247 (11%)

Query: 225 IHMF--RTAHNAREKLAESLRHENLQKR--ESISELISLRMFLNDTLSTFDDLEKAKTHL 280
           +H F  +   + +E L + L+ +  QKR  + +  L+S +       S  D   + KT +
Sbjct: 253 LHQFTEKVIQDRKESLKDKLKQDTTQKRRWDFLDILLSAKSENTKDFSEADLQAEVKTFM 312

Query: 281 VVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAEL 340
              +A    T  A  W L+ + + PE  +   +E++  L          G+   ++   L
Sbjct: 313 ---FAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELL----------GDGSSITWEHL 359

Query: 341 NDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEI 400
           + +P     IKE LRL +  +NI     D  +   DG  ++     + +    +H +P  
Sbjct: 360 SQMPYTTMCIKECLRLYAPVVNISRLL-DKPITFPDGR-SLPAGITVFINIWALHHNPYF 417

Query: 401 YPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLIL 460
           + DP  F   R+  EN +             Y ++PF +G   C G+ FAI E K  + L
Sbjct: 418 WEDPQVFNPLRFSRENSEKIHP---------YAFIPFSAGLRNCIGQHFAIIECKVAVAL 468

Query: 461 MLSYFEL 467
            L  F+L
Sbjct: 469 TLLRFKL 475


>gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 1 [Homo sapiens]
          Length = 504

 Score = 57.4 bits (137), Expect = 3e-08
 Identities = 65/303 (21%), Positives = 117/303 (38%), Gaps = 42/303 (13%)

Query: 186 TIFGRDLTRRDTQKAHILNNLDNFKQFD----------------KVFPALVAGL-PIHMF 228
           T+FG +L   +  +   L N+    + D                 VF AL  GL P  + 
Sbjct: 187 TLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVT 246

Query: 229 RTAHNAREKLAESLRHENLQKRESISELISLRMFLNDTLS--TFDDLEKAKTHLVVLWAS 286
               N+ E++ ES   +  + R    + +       +T S     DLE     +++++A+
Sbjct: 247 HFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAA 306

Query: 287 QANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVL 346
              T     + ++++  +P+  +   EE+   L N             ++   L  +  L
Sbjct: 307 YDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAP----------VTYDALVQMEYL 356

Query: 347 DSIIKESLRLSSASLNI-RTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPL 405
           D ++ E+LRL      + R  K+D    +E     I K   + +    +H DP+ + +P 
Sbjct: 357 DMVVNETLRLFPVVSRVTRVCKKD----IEINGVFIPKGLAVMVPIYALHHDPKYWTEPE 412

Query: 406 TFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYF 465
            F  +    +  K     Y         Y+PFG+G   C G  FA+  IK  +I  L  F
Sbjct: 413 KFCPESRFSKKNKDSIDLY--------RYIPFGAGPRNCIGMRFALTNIKLAVIRALQNF 464

Query: 466 ELE 468
             +
Sbjct: 465 SFK 467


>gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8
           [Homo sapiens]
          Length = 520

 Score = 56.6 bits (135), Expect = 5e-08
 Identities = 47/186 (25%), Positives = 80/186 (43%), Gaps = 21/186 (11%)

Query: 283 LWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELND 342
           ++     T     W L+ + R+PE  +   +EV+  L++   K         +   +L  
Sbjct: 326 MFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDREPKE--------IEWDDLAQ 377

Query: 343 LPVLDSIIKESLRLSSASLNI-RTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIY 401
           LP L   +KESLRL        R   +D  L     S  I K ++  +    +H +P ++
Sbjct: 378 LPFLTMCLKESLRLHPPIPTFARGCTQDVVL---PDSRVIPKGNVCNINIFAIHHNPSVW 434

Query: 402 PDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILM 461
           PDP  +   R+  EN + ++            ++PF +G   C G+ FA+ E+K  L L 
Sbjct: 435 PDPEVYDPFRFDPENAQKRSPMA---------FIPFSAGPRNCIGQKFAMAEMKVVLALT 485

Query: 462 LSYFEL 467
           L  F +
Sbjct: 486 LLRFRI 491


>gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide 1
           [Homo sapiens]
          Length = 544

 Score = 56.6 bits (135), Expect = 5e-08
 Identities = 70/286 (24%), Positives = 116/286 (40%), Gaps = 41/286 (14%)

Query: 223 LPIHMFRTAHNAREKLAESLR-----HENLQKRESISELISLRMF------LNDTLSTFD 271
           LP   F+      + +   L+     H+    RE+  + I + +        N++ S+FD
Sbjct: 279 LPFGPFKELRQIEKDITSFLKKIIKDHQESLDRENPQDFIDMYLLHMEEERKNNSNSSFD 338

Query: 272 DLEKAKTHLV--VLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLE 329
             E+   +++  +  A    T  +  W L  M  NP+  +   EE++R +  A +  SL 
Sbjct: 339 --EEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVI-GANRAPSL- 394

Query: 330 GNPICLSQAELNDLPVLDSIIKESLRLSSA-SLNIRTAKEDFTLHLEDGSYNIRKDDIIA 388
                    +   +P  ++ I E  RL+    L I     + T+      Y I K  +I 
Sbjct: 395 --------TDKAQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQ---GYTIPKGTLIL 443

Query: 389 LYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRL 448
                +H DP I+  P  F  +R+LD+ G+         L  K  ++PFG G  +C G  
Sbjct: 444 PNLWSVHRDPAIWEKPEDFYPNRFLDDQGQ---------LIKKETFIPFGIGKRVCMGEQ 494

Query: 449 FAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGLGILP-PLN 493
            A  E+    + ++  F   L E   K  PL   R GL + P P N
Sbjct: 495 LAKMELFLMFVSLMQSFAFALPEDSKK--PLLTGRFGLTLAPHPFN 538


>gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1
           isoform 1 precursor [Homo sapiens]
          Length = 514

 Score = 55.8 bits (133), Expect = 9e-08
 Identities = 43/191 (22%), Positives = 85/191 (44%), Gaps = 27/191 (14%)

Query: 285 ASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTL-ENAGQKVSLEGNPICLSQAELNDL 343
           A+   T  +  W L+ + RNP+  +   +E++  L EN   +             +L ++
Sbjct: 326 AAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAE-----------DLRNM 374

Query: 344 PVLDSIIKESLRLS-SASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYP 402
           P L + +KES+RL+ S     RT  +   L    G Y + K  ++ L  Q++    + + 
Sbjct: 375 PYLKACLKESMRLTPSVPFTTRTLDKATVL----GEYALPKGTVLMLNTQVLGSSEDNFE 430

Query: 403 DPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILML 462
           D   F+ +R+L E  K             + ++PFG G  +C GR  A  ++   L  ++
Sbjct: 431 DSSQFRPERWLQEKEKIN----------PFAHLPFGVGKRMCIGRRLAELQLHLALCWIV 480

Query: 463 SYFELELIEGQ 473
             ++++  + +
Sbjct: 481 RKYDIQATDNE 491


>gi|119829183 cytochrome P450, family 11, subfamily B, polypeptide 2
           precursor [Homo sapiens]
          Length = 503

 Score = 55.8 bits (133), Expect = 9e-08
 Identities = 56/246 (22%), Positives = 104/246 (42%), Gaps = 34/246 (13%)

Query: 227 MFRTAHNAREKLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWAS 286
           +F+   N  +K+ + L     Q    I   + L+  L+        LE  K + + L A 
Sbjct: 263 IFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELS--------LEAIKANSMELTAG 314

Query: 287 QANTIP-ATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPV 345
             +T       +LF++ RNP+  +   +E      +     S+  +P    Q    +LP+
Sbjct: 315 SVDTTAFPLLMTLFELARNPDVQQILRQE------SLAAAASISEHP----QKATTELPL 364

Query: 346 LDSIIKESLRLSSASLNI-RTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDP 404
           L + +KE+LRL    L + R    D  L     +Y+I    ++ ++   +  +  ++P P
Sbjct: 365 LRAALKETLRLYPVGLFLERVVSSDLVLQ----NYHIPAGTLVQVFLYSLGRNAALFPRP 420

Query: 405 LTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSY 464
             +   R+LD  G  +           ++++PFG G   C GR  A  E+   L  +L +
Sbjct: 421 ERYNPQRWLDIRGSGRN----------FHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKH 470

Query: 465 FELELI 470
           F +E +
Sbjct: 471 FLVETL 476


>gi|13449277 cytochrome P450, family 2, subfamily S, polypeptide 1
           [Homo sapiens]
          Length = 504

 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 58/240 (24%), Positives = 98/240 (40%), Gaps = 44/240 (18%)

Query: 270 FDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLE 329
           F +     T + +L+A          ++L  +++ P   K   EE+ R L  AGQ  SL 
Sbjct: 287 FTNKNMLMTVIYLLFAGTMTVSTTVGYTLLLLMKYPHVQKWVREELNREL-GAGQAPSL- 344

Query: 330 GNPICLSQAELNDLPVLDSIIKESLRLSSA-------SLNIRTAKEDFTLHLEDGSYNIR 382
                    +   LP  D+++ E+ RL +        +L   T    +TL         +
Sbjct: 345 --------GDRTRLPYTDAVLHEAQRLLALVPMGIPRTLMRTTRFRGYTLP--------Q 388

Query: 383 KDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGAT 442
             ++  L   ++H DP I+  P  F  DR+LD +G+          +    ++PF  G  
Sbjct: 389 GTEVFPLLGSILH-DPNIFKHPEEFNPDRFLDADGR---------FRKHEAFLPFSLGKR 438

Query: 443 ICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPP----LDQSRAGLGILPPLNDIEFK 498
           +C G   A  E+  F   +L  F LE     + CPP    L  + +GL  +PP   ++ +
Sbjct: 439 VCLGEGLAKAELFLFFTTILQAFSLE-----SPCPPDTLSLKPTVSGLFNIPPAFQLQVR 493


>gi|29837648 cytochrome P450, family 4, subfamily X, polypeptide 1
           [Homo sapiens]
          Length = 509

 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 54/234 (23%), Positives = 100/234 (42%), Gaps = 23/234 (9%)

Query: 235 REKLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPAT 294
           ++ L   ++ +N  KR+    L  +    +++ S+F D++        L A       + 
Sbjct: 266 KKSLQAGVKQDNTPKRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAGHDTLAASI 325

Query: 295 FWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESL 354
            W L+ +  NPE  +   EEV+  L          G+   ++  +L ++      IKE+ 
Sbjct: 326 SWILYCLALNPEHQERCREEVRGIL----------GDGSSITWDQLGEMSYTTMCIKETC 375

Query: 355 RLSSASLNI-RTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYL 413
           RL  A  +I R   +  T    DG   +     + L    +H +P ++ +P  F   R+ 
Sbjct: 376 RLIPAVPSISRDLSKPLTF--PDGC-TLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFS 432

Query: 414 DENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFEL 467
            EN   +           Y Y+PF +G+  C G+ FA+ E+K  + L+L +F +
Sbjct: 433 QENSDQRHP---------YAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRV 477


>gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide 9
           [Homo sapiens]
          Length = 490

 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 108/521 (20%), Positives = 191/521 (36%), Gaps = 90/521 (17%)

Query: 10  IAIAACCCLWLILGIRRRQTGEPPLENGL--IPYLGCALQFGANPLEFLRANQRK-HGHV 66
           + +  C    L+L + R+ +G   L  G   +P +G  LQ G   +     N  K +G V
Sbjct: 5   VVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPV 64

Query: 67  FTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPM--------- 117
           FT       ++F   P+    V+ HG  ++  K       + F  R I P+         
Sbjct: 65  FT-------LYFGLKPI----VVLHG--YEAVKEALIDLGEEFSGRGIFPLAERANRGFG 111

Query: 118 ----DGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYS 173
               +G   + I    + TL+   +     S+ + +Q   R  V    KT A   +  + 
Sbjct: 112 IVFSNGKKWKEIRRFSLMTLRNFGMGK--RSIEDRVQEEARCLVEELRKTKASPCDPTFI 169

Query: 174 F----CYRVMFEAGYLTIFGRDLTRRDTQKAHILNNL-DNFKQFDKVFPALVAGLP--IH 226
                C  +        IF +    +D Q  +++  L +N K     +  +       I 
Sbjct: 170 LGCAPCNVICS-----IIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIID 224

Query: 227 MFRTAHNAREKLAESLRHENLQKRESISELISLRM---FLNDTLSTFDD----------L 273
            F   HN   K    ++   L+K +   E + +     F++  L   +           +
Sbjct: 225 YFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTI 284

Query: 274 EKAKTHLVVLWASQANTIPATF-WSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNP 332
           E  +   V L+ +   T   T  ++L  ++++PE      EE++R +          G  
Sbjct: 285 ESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVI----------GRN 334

Query: 333 ICLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQ 392
                 + + +P  D+++ E  R     L   +     T  ++  +Y I K   I +   
Sbjct: 335 RSPCMQDRSHMPYTDAVVHEVQRY--IDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLT 392

Query: 393 LMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIH 452
            +  D + +P+P  F    +LDE G  K +          Y+MPF +G  IC G   A  
Sbjct: 393 SVLHDNKEFPNPEMFDPHHFLDEGGNFKKS---------KYFMPFSAGKRICVGEALAGM 443

Query: 453 EIKQFLILMLSYFELE------------LIEGQAKCPPLDQ 481
           E+  FL  +L  F L+            ++ G A  PP  Q
Sbjct: 444 ELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQ 484


>gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide 8
           [Homo sapiens]
          Length = 490

 Score = 53.9 bits (128), Expect = 3e-07
 Identities = 109/524 (20%), Positives = 193/524 (36%), Gaps = 77/524 (14%)

Query: 10  IAIAACCCLWLILGIRRRQTGEPPLENGL--IPYLGCALQFGANPLEFLRANQRK-HGHV 66
           + +  C    L+  + R+      L  G   +P +G  LQ     +     N  K +G V
Sbjct: 5   VVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPV 64

Query: 67  FTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDGNTTENI- 125
           FT       V+F  NP+    V+ HG  ++  K     + + F  R   P+    T+ + 
Sbjct: 65  FT-------VYFGMNPI----VVFHG--YEAVKEALIDNGEEFSGRGNSPISQRITKGLG 111

Query: 126 ----NDTFIKTLQGHALNSL-----------------TESMMENLQRIMRPPVSSNSKTA 164
               N    K ++  +L +L                    ++E L++    P        
Sbjct: 112 IISSNGKRWKEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILG 171

Query: 165 AWVTEGMYSFCYRVMFE---AGYLTIFGRDLTRRDTQKAHILNN-----LDNFKQFDKVF 216
                 + S  ++  F+     +LT     L +R  +   ILN+      +NF      F
Sbjct: 172 CAPCNVICSVVFQKRFDYKDQNFLT-----LMKRFNENFRILNSPWIQVCNNFPLLIDCF 226

Query: 217 PALVAGLPIHMFRTAHNAREKLAESLRHENLQKRESISELISLRMFLN-DTLSTFDDLEK 275
           P     +  ++  T    REK+ E     ++       +   ++M    D   +  ++E 
Sbjct: 227 PGTHNKVLKNVALTRSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIEN 286

Query: 276 AKTHLVVLWASQANTIPATF-WSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPIC 334
               +  L+ +   T   T  + L  ++++PE      EE+   +          G    
Sbjct: 287 LVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVI----------GRHRS 336

Query: 335 LSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDD-IIALYPQL 393
               + + +P  D+++ E  R S   L         T   +  +Y I K   I+AL   +
Sbjct: 337 PCMQDRSHMPYTDAVVHEIQRYSD--LVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSV 394

Query: 394 MHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHE 453
           +H D E +P+P  F    +LD+NG  K + Y         +MPF +G  IC G   A  E
Sbjct: 395 LHDDKE-FPNPNIFDPGHFLDKNGNFKKSDY---------FMPFSAGKRICAGEGLARME 444

Query: 454 IKQFLILMLSYFELELIEGQAKCPPLDQSRAGLGILPPLNDIEF 497
           +  FL  +L  F L+ ++          ++ G+  LPP   I F
Sbjct: 445 LFLFLTTILQNFNLKSVDDLKNLNTTAVTK-GIVSLPPSYQICF 487


>gi|167466231 cytochrome P450, family 27, subfamily C, polypeptide 1
           [Homo sapiens]
          Length = 372

 Score = 53.1 bits (126), Expect = 6e-07
 Identities = 75/353 (21%), Positives = 144/353 (40%), Gaps = 54/353 (15%)

Query: 118 DGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYR 177
           DG T  N+ND F K         L ES +  L+  + P ++     A    E M+S  ++
Sbjct: 42  DGETVTNVNDLFFKYSMEGVATILYESRLGCLENSI-PQLTVEYIEAL---ELMFSM-FK 96

Query: 178 VMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREK 237
               AG +  + R    +             +++F + +  L     IH+     + + +
Sbjct: 97  TSMYAGAIPRWLRPFIPKP------------WREFCRSWDGLFKFSQIHVDNKLRDIQYQ 144

Query: 238 LAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATF-W 296
           +    R         +S  +   +FL+  L+    L++   ++  +  +  +T   T  W
Sbjct: 145 MDRGRR---------VSGGLLTYLFLSQALT----LQEIYANVTEMLLAGVDTTSFTLSW 191

Query: 297 SLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRL 356
           +++ + R+PE  +    E+ + L          G     + A++  +P++ +++KE+LRL
Sbjct: 192 TVYLLARHPEVQQTVYREIVKNL----------GERHVPTAADVPKVPLVRALLKETLRL 241

Query: 357 SSASL-NIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDE 415
                 N R  +ED  +    G Y I K   +AL         E +P    F+ +R+L +
Sbjct: 242 FPVLPGNGRVTQEDLVI----GGYLIPKGTQLALCHYATSYQDENFPRAKEFRPERWLRK 297

Query: 416 NGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELE 468
               +   + +        +PFG G   C GR  A  EI   +I +L +FE++
Sbjct: 298 GDLDRVDNFGS--------IPFGHGVRSCIGRRIAELEIHLVVIQLLQHFEIK 342


>gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide 1
           [Homo sapiens]
          Length = 493

 Score = 52.8 bits (125), Expect = 7e-07
 Identities = 48/210 (22%), Positives = 84/210 (40%), Gaps = 22/210 (10%)

Query: 282 VLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELN 341
           + +A    T     + L  +++ PE  +   EE+ R +          G     +  +  
Sbjct: 296 LFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVI----------GPSRIPAIKDRQ 345

Query: 342 DLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIY 401
           ++P +D+++ E  R    +L       + T       Y I K  ++      +  D + +
Sbjct: 346 EMPYMDAVVHEIQRF--ITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEF 403

Query: 402 PDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILM 461
           PDP  FK + +L+ENGK          K   Y+ PF +G  +C G   A  E+   L  +
Sbjct: 404 PDPEKFKPEHFLNENGK---------FKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAI 454

Query: 462 LSYFELELIEGQAKCPPLDQSRAGLGILPP 491
           L +F L+ +    K   L     G G +PP
Sbjct: 455 LQHFNLKPLV-DPKDIDLSPIHIGFGCIPP 483


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.138    0.421 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,641,675
Number of Sequences: 37866
Number of extensions: 789194
Number of successful extensions: 2027
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 39
Number of HSP's successfully gapped in prelim test: 38
Number of HSP's that attempted gapping in prelim test: 1886
Number of HSP's gapped (non-prelim): 90
length of query: 504
length of database: 18,247,518
effective HSP length: 107
effective length of query: 397
effective length of database: 14,195,856
effective search space: 5635754832
effective search space used: 5635754832
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.