Guide to the Human Genome
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Search of human proteins with 163914373

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|163914373 solute carrier family 8 (sodium/calcium
exchanger), member 1 isoform D [Homo sapiens]
         (937 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|163914373 solute carrier family 8 (sodium/calcium exchanger),...  1872   0.0  
gi|163914371 solute carrier family 8 (sodium/calcium exchanger),...  1859   0.0  
gi|163914369 solute carrier family 8 (sodium/calcium exchanger),...  1810   0.0  
gi|10863913 solute carrier family 8 (sodium/calcium exchanger), ...  1808   0.0  
gi|33946311 solute carrier family 8 (sodium/calcium exchanger), ...  1326   0.0  
gi|33946304 solute carrier family 8 (sodium/calcium exchanger), ...  1324   0.0  
gi|17865805 solute carrier family 8 (sodium/calcium exchanger), ...  1323   0.0  
gi|15147254 solute carrier family 8 (sodium/calcium exchanger), ...  1306   0.0  
gi|57163987 solute carrier family 8 member 2 [Homo sapiens]          1216   0.0  
gi|194354001 solute carrier family 8 (sodium/calcium exchanger),...   475   e-134
gi|33946308 solute carrier family 8 (sodium/calcium exchanger), ...   471   e-132
gi|113722120 G protein-coupled receptor 98 precursor [Homo sapiens]    84   5e-16
gi|169167211 PREDICTED: FRAS1 related extracellular matrix 3 [Ho...    74   5e-13
gi|169166904 PREDICTED: FRAS1 related extracellular matrix 3 [Ho...    74   5e-13
gi|169166334 PREDICTED: FRAS1 related extracellular matrix 3 [Ho...    74   5e-13
gi|79749430 FRAS1-related extracellular matrix protein 2 precurs...    70   9e-12
gi|108773804 Fraser syndrome 1 [Homo sapiens]                          69   2e-11
gi|31563526 solute carrier family 24 (sodium/potassium/calcium e...    68   3e-11
gi|29788987 solute carrier family 24 member 4 isoform 3 [Homo sa...    65   2e-10
gi|29788985 solute carrier family 24 member 4 isoform 2 precurso...    65   2e-10
gi|24111228 solute carrier family 24 member 4 isoform 1 precurso...    65   2e-10
gi|45504369 solute carrier family 24, member 5 [Homo sapiens]          64   9e-10
gi|9966787 solute carrier family 24 (sodium/potassium/calcium ex...    59   3e-08
gi|54607027 integrin beta 4 isoform 2 precursor [Homo sapiens]         51   6e-06
gi|54607035 integrin beta 4 isoform 1 precursor [Homo sapiens]         51   6e-06
gi|54607033 integrin beta 4 isoform 3 precursor [Homo sapiens]         51   6e-06
gi|4759128 solute carrier family 24 (sodium/potassium/calcium ex...    51   6e-06
gi|122056683 FRAS1 related extracellular matrix 1 [Homo sapiens]       45   3e-04
gi|39995086 solute carrier family 24 member 6 [Homo sapiens]           37   0.11 
gi|209862785 anoctamin 2 [Homo sapiens]                                36   0.15 

>gi|163914373 solute carrier family 8 (sodium/calcium exchanger),
           member 1 isoform D [Homo sapiens]
          Length = 937

 Score = 1872 bits (4849), Expect = 0.0
 Identities = 937/937 (100%), Positives = 937/937 (100%)

Query: 1   MYNMRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIAETEMEGEGNETGECTGSYYCKKGVI 60
           MYNMRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIAETEMEGEGNETGECTGSYYCKKGVI
Sbjct: 1   MYNMRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIAETEMEGEGNETGECTGSYYCKKGVI 60

Query: 61  LPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPNG 120
           LPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPNG
Sbjct: 61  LPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPNG 120

Query: 121 ETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMF 180
           ETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMF
Sbjct: 121 ETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMF 180

Query: 181 IIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFF 240
           IIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFF
Sbjct: 181 IIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFF 240

Query: 241 FFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHV 300
           FFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHV
Sbjct: 241 FFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHV 300

Query: 301 ENFLDGALVLEVDERDQDDEEARREMARILKELKQKHPDKEIEQLIELANYQVLSQQQKS 360
           ENFLDGALVLEVDERDQDDEEARREMARILKELKQKHPDKEIEQLIELANYQVLSQQQKS
Sbjct: 301 ENFLDGALVLEVDERDQDDEEARREMARILKELKQKHPDKEIEQLIELANYQVLSQQQKS 360

Query: 361 RAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVTENDPVSKIFFEQGTYQCLE 420
           RAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVTENDPVSKIFFEQGTYQCLE
Sbjct: 361 RAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVTENDPVSKIFFEQGTYQCLE 420

Query: 421 NCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGII 480
           NCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGII
Sbjct: 421 NCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGII 480

Query: 481 DDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHAGIF 540
           DDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHAGIF
Sbjct: 481 DDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHAGIF 540

Query: 541 TFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQND 600
           TFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQND
Sbjct: 541 TFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQND 600

Query: 601 EIVKIITIRIFDREEYEKECSFSLVLEEPKWIRRGMKGGFTITDEYDDKQPLTSKEEEER 660
           EIVKIITIRIFDREEYEKECSFSLVLEEPKWIRRGMKGGFTITDEYDDKQPLTSKEEEER
Sbjct: 601 EIVKIITIRIFDREEYEKECSFSLVLEEPKWIRRGMKGGFTITDEYDDKQPLTSKEEEER 660

Query: 661 RIAEMGRPILGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTNSWREQFIEAITVSA 720
           RIAEMGRPILGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTNSWREQFIEAITVSA
Sbjct: 661 RIAEMGRPILGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTNSWREQFIEAITVSA 720

Query: 721 GEDDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWNGWACFIVSILMIGLLTA 780
           GEDDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWNGWACFIVSILMIGLLTA
Sbjct: 721 GEDDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWNGWACFIVSILMIGLLTA 780

Query: 781 FIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAV 840
           FIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAV
Sbjct: 781 FIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAV 840

Query: 841 NVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGE 900
           NVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGE
Sbjct: 841 NVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGE 900

Query: 901 LGGPRTAKLLTSCLFVLLWLLYIFFSSLEAYCHIKGF 937
           LGGPRTAKLLTSCLFVLLWLLYIFFSSLEAYCHIKGF
Sbjct: 901 LGGPRTAKLLTSCLFVLLWLLYIFFSSLEAYCHIKGF 937


>gi|163914371 solute carrier family 8 (sodium/calcium exchanger),
           member 1 isoform C [Homo sapiens]
          Length = 960

 Score = 1859 bits (4815), Expect = 0.0
 Identities = 937/960 (97%), Positives = 937/960 (97%), Gaps = 23/960 (2%)

Query: 1   MYNMRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIAETEMEGEGNETGECTGSYYCKKGVI 60
           MYNMRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIAETEMEGEGNETGECTGSYYCKKGVI
Sbjct: 1   MYNMRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIAETEMEGEGNETGECTGSYYCKKGVI 60

Query: 61  LPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPNG 120
           LPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPNG
Sbjct: 61  LPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPNG 120

Query: 121 ETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMF 180
           ETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMF
Sbjct: 121 ETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMF 180

Query: 181 IIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFF 240
           IIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFF
Sbjct: 181 IIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFF 240

Query: 241 FFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHV 300
           FFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHV
Sbjct: 241 FFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHV 300

Query: 301 ENFLDGALVLEVDERDQDDEEARREMARILKELKQKHPDKEIEQLIELANYQVLSQQQKS 360
           ENFLDGALVLEVDERDQDDEEARREMARILKELKQKHPDKEIEQLIELANYQVLSQQQKS
Sbjct: 301 ENFLDGALVLEVDERDQDDEEARREMARILKELKQKHPDKEIEQLIELANYQVLSQQQKS 360

Query: 361 RAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVTENDPVSKIFFEQGTYQCLE 420
           RAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVTENDPVSKIFFEQGTYQCLE
Sbjct: 361 RAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVTENDPVSKIFFEQGTYQCLE 420

Query: 421 NCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGII 480
           NCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGII
Sbjct: 421 NCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGII 480

Query: 481 DDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHAGIF 540
           DDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHAGIF
Sbjct: 481 DDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHAGIF 540

Query: 541 TFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQND 600
           TFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQND
Sbjct: 541 TFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQND 600

Query: 601 EIVKIITIRIFDREEYEKECSFSLVLEEPKWIRRGMKGGFTIT----------------- 643
           EIVKIITIRIFDREEYEKECSFSLVLEEPKWIRRGMKGGFTIT                 
Sbjct: 601 EIVKIITIRIFDREEYEKECSFSLVLEEPKWIRRGMKGGFTITGQPVFRKVHAREHPILS 660

Query: 644 ------DEYDDKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIEESYEFKSTVDKLIKKT 697
                 DEYDDKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIEESYEFKSTVDKLIKKT
Sbjct: 661 TVITIADEYDDKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIEESYEFKSTVDKLIKKT 720

Query: 698 NLALVVGTNSWREQFIEAITVSAGEDDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVP 757
           NLALVVGTNSWREQFIEAITVSAGEDDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVP
Sbjct: 721 NLALVVGTNSWREQFIEAITVSAGEDDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVP 780

Query: 758 PTEYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFAS 817
           PTEYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFAS
Sbjct: 781 PTEYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFAS 840

Query: 818 KVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTL 877
           KVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTL
Sbjct: 841 KVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTL 900

Query: 878 FTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWLLYIFFSSLEAYCHIKGF 937
           FTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWLLYIFFSSLEAYCHIKGF
Sbjct: 901 FTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWLLYIFFSSLEAYCHIKGF 960


>gi|163914369 solute carrier family 8 (sodium/calcium exchanger),
           member 1 isoform B [Homo sapiens]
          Length = 968

 Score = 1810 bits (4687), Expect = 0.0
 Identities = 916/968 (94%), Positives = 924/968 (95%), Gaps = 31/968 (3%)

Query: 1   MYNMRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIAETEMEGEGNETGECTGSYYCKKGVI 60
           MYNMRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIAETEMEGEGNETGECTGSYYCKKGVI
Sbjct: 1   MYNMRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIAETEMEGEGNETGECTGSYYCKKGVI 60

Query: 61  LPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPNG 120
           LPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPNG
Sbjct: 61  LPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPNG 120

Query: 121 ETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMF 180
           ETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMF
Sbjct: 121 ETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMF 180

Query: 181 IIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFF 240
           IIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFF
Sbjct: 181 IIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFF 240

Query: 241 FFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHV 300
           FFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHV
Sbjct: 241 FFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHV 300

Query: 301 ENFLDGALVLEVDERDQDDEEARREMARILKELKQKHPDKEIEQLIELANYQVLSQQQKS 360
           ENFLDGALVLEVDERDQDDEEARREMARILKELKQKHPDKEIEQLIELANYQVLSQQQKS
Sbjct: 301 ENFLDGALVLEVDERDQDDEEARREMARILKELKQKHPDKEIEQLIELANYQVLSQQQKS 360

Query: 361 RAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVTENDPVSKIFFEQGTYQCLE 420
           RAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVTENDPVSKIFFEQGTYQCLE
Sbjct: 361 RAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVTENDPVSKIFFEQGTYQCLE 420

Query: 421 NCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGII 480
           NCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGII
Sbjct: 421 NCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGII 480

Query: 481 DDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHAGIF 540
           DDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHAGIF
Sbjct: 481 DDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHAGIF 540

Query: 541 TFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQND 600
           TFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQND
Sbjct: 541 TFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQND 600

Query: 601 EIVKIITIRIFDREEYEKECSFSLVLEEPKWIRRGMK--------GGFTIT--------- 643
           EIVK I++++ D EEYEK  +F L + EP+ +    K        GGFTIT         
Sbjct: 601 EIVKTISVKVIDDEEYEKNKTFFLEIGEPRLVEMSEKKALLLNELGGFTITGQPVFRKVH 660

Query: 644 --------------DEYDDKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIEESYEFKST 689
                         DEYDDKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIEESYEFKST
Sbjct: 661 AREHPILSTVITIADEYDDKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIEESYEFKST 720

Query: 690 VDKLIKKTNLALVVGTNSWREQFIEAITVSAGEDDDDDECGEEKLPSCFDYVMHFLTVFW 749
           VDKLIKKTNLALVVGTNSWREQFIEAITVSAGEDDDDDECGEEKLPSCFDYVMHFLTVFW
Sbjct: 721 VDKLIKKTNLALVVGTNSWREQFIEAITVSAGEDDDDDECGEEKLPSCFDYVMHFLTVFW 780

Query: 750 KVLFAFVPPTEYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGT 809
           KVLFAFVPPTEYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGT
Sbjct: 781 KVLFAFVPPTEYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGT 840

Query: 810 SVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPG 869
           SVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPG
Sbjct: 841 SVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPG 900

Query: 870 TLAFSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWLLYIFFSSLE 929
           TLAFSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWLLYIFFSSLE
Sbjct: 901 TLAFSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWLLYIFFSSLE 960

Query: 930 AYCHIKGF 937
           AYCHIKGF
Sbjct: 961 AYCHIKGF 968


>gi|10863913 solute carrier family 8 (sodium/calcium exchanger),
           member 1 isoform A [Homo sapiens]
          Length = 973

 Score = 1808 bits (4682), Expect = 0.0
 Identities = 916/973 (94%), Positives = 924/973 (94%), Gaps = 36/973 (3%)

Query: 1   MYNMRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIAETEMEGEGNETGECTGSYYCKKGVI 60
           MYNMRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIAETEMEGEGNETGECTGSYYCKKGVI
Sbjct: 1   MYNMRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIAETEMEGEGNETGECTGSYYCKKGVI 60

Query: 61  LPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPNG 120
           LPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPNG
Sbjct: 61  LPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPNG 120

Query: 121 ETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMF 180
           ETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMF
Sbjct: 121 ETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMF 180

Query: 181 IIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFF 240
           IIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFF
Sbjct: 181 IIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFF 240

Query: 241 FFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHV 300
           FFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHV
Sbjct: 241 FFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHV 300

Query: 301 ENFLDGALVLEVDERDQDDEEARREMARILKELKQKHPDKEIEQLIELANYQVLSQQQKS 360
           ENFLDGALVLEVDERDQDDEEARREMARILKELKQKHPDKEIEQLIELANYQVLSQQQKS
Sbjct: 301 ENFLDGALVLEVDERDQDDEEARREMARILKELKQKHPDKEIEQLIELANYQVLSQQQKS 360

Query: 361 RAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVTENDPVSKIFFEQGTYQCLE 420
           RAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVTENDPVSKIFFEQGTYQCLE
Sbjct: 361 RAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVTENDPVSKIFFEQGTYQCLE 420

Query: 421 NCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGII 480
           NCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGII
Sbjct: 421 NCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGII 480

Query: 481 DDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHAGIF 540
           DDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHAGIF
Sbjct: 481 DDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHAGIF 540

Query: 541 TFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQND 600
           TFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQND
Sbjct: 541 TFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQND 600

Query: 601 EIVKIITIRIFDREEYEKECSFSLVLEEPKWIRRGMK--------GGFTIT--------- 643
           EIVK I++++ D EEYEK  +F L + EP+ +    K        GGFTIT         
Sbjct: 601 EIVKTISVKVIDDEEYEKNKTFFLEIGEPRLVEMSEKKALLLNELGGFTITGKYLFGQPV 660

Query: 644 -------------------DEYDDKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIEESY 684
                              DEYDDKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIEESY
Sbjct: 661 FRKVHAREHPILSTVITIADEYDDKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIEESY 720

Query: 685 EFKSTVDKLIKKTNLALVVGTNSWREQFIEAITVSAGEDDDDDECGEEKLPSCFDYVMHF 744
           EFKSTVDKLIKKTNLALVVGTNSWREQFIEAITVSAGEDDDDDECGEEKLPSCFDYVMHF
Sbjct: 721 EFKSTVDKLIKKTNLALVVGTNSWREQFIEAITVSAGEDDDDDECGEEKLPSCFDYVMHF 780

Query: 745 LTVFWKVLFAFVPPTEYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVF 804
           LTVFWKVLFAFVPPTEYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVF
Sbjct: 781 LTVFWKVLFAFVPPTEYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVF 840

Query: 805 VALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQF 864
           VALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQF
Sbjct: 841 VALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQF 900

Query: 865 KVSPGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWLLYIF 924
           KVSPGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWLLYIF
Sbjct: 901 KVSPGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWLLYIF 960

Query: 925 FSSLEAYCHIKGF 937
           FSSLEAYCHIKGF
Sbjct: 961 FSSLEAYCHIKGF 973


>gi|33946311 solute carrier family 8 (sodium/calcium exchanger),
           member 3 isoform C precursor [Homo sapiens]
          Length = 927

 Score = 1326 bits (3431), Expect = 0.0
 Identities = 673/942 (71%), Positives = 782/942 (83%), Gaps = 23/942 (2%)

Query: 4   MRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIAETEMEGEGNETGE----CTGSYYCKKGV 59
           M  L L P  S   H  +   +LF  ++ + AE    G+   TG+    C+GS  CK+GV
Sbjct: 1   MAWLRLQPLTSAFLHFGLVTFVLF--LNGLRAEAGGSGDVPSTGQNNESCSGSSDCKEGV 58

Query: 60  ILPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPN 119
           ILPIW P++PS GDKIAR  VYFVA++YMFLGVSIIADRFM+SIEVITSQE+E+TIKKPN
Sbjct: 59  ILPIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPN 118

Query: 120 GETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNM 179
           GET+ TT+R+WNETVSNLTLMALGSSAPEILLS+IEVCGH F AGDLGPSTIVGSAAFNM
Sbjct: 119 GETSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNM 178

Query: 180 FIIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTF 239
           FIII +CVYV+PDGETRKIKHLRVFF+TAAWSIFAY WLY+IL+V SPGVV+VWEGLLT 
Sbjct: 179 FIIIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTL 238

Query: 240 FFFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSH 299
           FFFP+CV+ AWVAD+RLLFYKY++K+YR  K RG+IIE EGD P     IEMDGK++NSH
Sbjct: 239 FFFPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKG---IEMDGKMMNSH 295

Query: 300 VENFLDGALV-LEVDERDQDDEEARREMARILKELKQKHPDKEIEQLIELANYQVLSQQQ 358
              FLDG LV LE  E D    E+RREM RILK+LKQKHP+K+++QL+E+ANY  LS QQ
Sbjct: 296 ---FLDGNLVPLEGKEVD----ESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQ 348

Query: 359 KSRAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVTENDPVSKIFFEQGTYQC 418
           KSRAFYRIQATR+MTGAGNILK+HAA+QA+KA SM EV+T+  E D +SK+FF+  +YQC
Sbjct: 349 KSRAFYRIQATRMMTGAGNILKKHAAEQAKKASSMSEVHTDEPE-DFISKVFFDPCSYQC 407

Query: 419 LENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVG 478
           LENCG V LT++R+GGD++ T++VD++TEDG+ANAG+DYEFTEGTVV KPG+TQKE  VG
Sbjct: 408 LENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVG 467

Query: 479 IIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVST---LACLGSPSTATVTIFDDD 535
           IIDDDIFEEDE+F V LSNV++  E  E+G+  A   S     A L SP  ATVTI DDD
Sbjct: 468 IIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDD 527

Query: 536 HAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGEL 595
           HAGIFTFE    HVSESIG+MEVKVLRTSGARG VIVP++T+EGTA+GGGEDFEDT GEL
Sbjct: 528 HAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGEL 587

Query: 596 EFQNDEIVKIITIRIFDREEYEKECSFSLVLEEPKWIRRGMKGGFTITDEYDDKQPLTSK 655
           EF+NDE VK I ++I D EEYE++ +F + L EPKW+ RG+       D  D K  LT +
Sbjct: 588 EFKNDETVKTIRVKIVDEEEYERQENFFIALGEPKWMERGISALLLSPDVTDRK--LTME 645

Query: 656 EEEERRIAEMGRPILGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTNSWREQFIEA 715
           EEE +RIAEMG+P+LGEH KLEVIIEESYEFK+TVDKLIKKTNLALVVGT+SWR+QF+EA
Sbjct: 646 EEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFMEA 705

Query: 716 ITVSAGEDDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWNGWACFIVSILMI 775
           ITVSA  D+D+DE GEE+LPSCFDYVMHFLTVFWKVLFA VPPTEY +GWACF VSIL+I
Sbjct: 706 ITVSAAGDEDEDESGEERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSILII 765

Query: 776 GLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVT 835
           G+LTA IGDLASHFGCTIGLKDSVTAVVFVA GTSVPDTFASK AA QD YADASIGNVT
Sbjct: 766 GMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVT 825

Query: 836 GSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTLFTIFAFINVGVLLYRRRP 895
           GSNAVNVFLGIG+AWS+AAIY A  G++F VS GTLAFSVTLFTIFAF+ + VLLYRRRP
Sbjct: 826 GSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRRP 885

Query: 896 EIGGELGGPRTAKLLTSCLFVLLWLLYIFFSSLEAYCHIKGF 937
            +GGELGGPR  KL T+ LFV LWLLYI F++LEAYC+IKGF
Sbjct: 886 HLGGELGGPRGCKLATTWLFVSLWLLYILFATLEAYCYIKGF 927


>gi|33946304 solute carrier family 8 (sodium/calcium exchanger),
           member 3 isoform D precursor [Homo sapiens]
          Length = 921

 Score = 1324 bits (3426), Expect = 0.0
 Identities = 674/942 (71%), Positives = 783/942 (83%), Gaps = 29/942 (3%)

Query: 4   MRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIAETEMEGEGNETGE----CTGSYYCKKGV 59
           M  L L P  S   H  +   +LF  ++ + AE    G+   TG+    C+GS  CK+GV
Sbjct: 1   MAWLRLQPLTSAFLHFGLVTFVLF--LNGLRAEAGGSGDVPSTGQNNESCSGSSDCKEGV 58

Query: 60  ILPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPN 119
           ILPIW P++PS GDKIAR  VYFVA++YMFLGVSIIADRFM+SIEVITSQE+E+TIKKPN
Sbjct: 59  ILPIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPN 118

Query: 120 GETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNM 179
           GET+ TT+R+WNETVSNLTLMALGSSAPEILLS+IEVCGH F AGDLGPSTIVGSAAFNM
Sbjct: 119 GETSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNM 178

Query: 180 FIIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTF 239
           FIII +CVYV+PDGETRKIKHLRVFF+TAAWSIFAY WLY+IL+V SPGVV+VWEGLLT 
Sbjct: 179 FIIIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTL 238

Query: 240 FFFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSH 299
           FFFP+CV+ AWVAD+RLLFYKY++K+YR  K RG+IIE EGD P     IEMDGK++NSH
Sbjct: 239 FFFPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKG---IEMDGKMMNSH 295

Query: 300 VENFLDGALV-LEVDERDQDDEEARREMARILKELKQKHPDKEIEQLIELANYQVLSQQQ 358
              FLDG LV LE  E D    E+RREM RILK+LKQKHP+K+++QL+E+ANY  LS QQ
Sbjct: 296 ---FLDGNLVPLEGKEVD----ESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQ 348

Query: 359 KSRAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVTENDPVSKIFFEQGTYQC 418
           KSRAFYRIQATR+MTGAGNILK+HAA+QA+KA SM EV+T+  E D +SK+FF+  +YQC
Sbjct: 349 KSRAFYRIQATRMMTGAGNILKKHAAEQAKKASSMSEVHTDEPE-DFISKVFFDPCSYQC 407

Query: 419 LENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVG 478
           LENCG V LT++R+GGD++ T++VD++TEDG+ANAG+DYEFTEGTVV KPG+TQKE  VG
Sbjct: 408 LENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVG 467

Query: 479 IIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVST---LACLGSPSTATVTIFDDD 535
           IIDDDIFEEDE+F V LSNV++  E  E+G+  A   S     A L SP  ATVTI DDD
Sbjct: 468 IIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDD 527

Query: 536 HAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGEL 595
           HAGIFTFE    HVSESIG+MEVKVLRTSGARG VIVP++T+EGTA+GGGEDFEDT GEL
Sbjct: 528 HAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGEL 587

Query: 596 EFQNDEIVKIITIRIFDREEYEKECSFSLVLEEPKWIRRGMKGGFTITDEYDDKQPLTSK 655
           EF+NDE VK I ++I D EEYE++ +F + L EPKW+ RG      I+D  D K  LT +
Sbjct: 588 EFKNDETVKTIRVKIVDEEEYERQENFFIALGEPKWMERG------ISDVTDRK--LTME 639

Query: 656 EEEERRIAEMGRPILGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTNSWREQFIEA 715
           EEE +RIAEMG+P+LGEH KLEVIIEESYEFK+TVDKLIKKTNLALVVGT+SWR+QF+EA
Sbjct: 640 EEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFMEA 699

Query: 716 ITVSAGEDDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWNGWACFIVSILMI 775
           ITVSA  D+D+DE GEE+LPSCFDYVMHFLTVFWKVLFA VPPTEY +GWACF VSIL+I
Sbjct: 700 ITVSAAGDEDEDESGEERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSILII 759

Query: 776 GLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVT 835
           G+LTA IGDLASHFGCTIGLKDSVTAVVFVA GTSVPDTFASK AA QD YADASIGNVT
Sbjct: 760 GMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVT 819

Query: 836 GSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTLFTIFAFINVGVLLYRRRP 895
           GSNAVNVFLGIG+AWS+AAIY A  G++F VS GTLAFSVTLFTIFAF+ + VLLYRRRP
Sbjct: 820 GSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRRP 879

Query: 896 EIGGELGGPRTAKLLTSCLFVLLWLLYIFFSSLEAYCHIKGF 937
            +GGELGGPR  KL T+ LFV LWLLYI F++LEAYC+IKGF
Sbjct: 880 HLGGELGGPRGCKLATTWLFVSLWLLYILFATLEAYCYIKGF 921


>gi|17865805 solute carrier family 8 (sodium/calcium exchanger),
           member 3 isoform B precursor [Homo sapiens]
          Length = 924

 Score = 1323 bits (3423), Expect = 0.0
 Identities = 671/942 (71%), Positives = 781/942 (82%), Gaps = 26/942 (2%)

Query: 4   MRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIAETEMEGEGNETGE----CTGSYYCKKGV 59
           M  L L P  S   H  +   +LF  ++ + AE    G+   TG+    C+GS  CK+GV
Sbjct: 1   MAWLRLQPLTSAFLHFGLVTFVLF--LNGLRAEAGGSGDVPSTGQNNESCSGSSDCKEGV 58

Query: 60  ILPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPN 119
           ILPIW P++PS GDKIAR  VYFVA++YMFLGVSIIADRFM+SIEVITSQE+E+TIKKPN
Sbjct: 59  ILPIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPN 118

Query: 120 GETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNM 179
           GET+ TT+R+WNETVSNLTLMALGSSAPEILLS+IEVCGH F AGDLGPSTIVGSAAFNM
Sbjct: 119 GETSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNM 178

Query: 180 FIIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTF 239
           FIII +CVYV+PDGETRKIKHLRVFF+TAAWSIFAY WLY+IL+V SPGVV+VWEGLLT 
Sbjct: 179 FIIIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTL 238

Query: 240 FFFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSH 299
           FFFP+CV+ AWVAD+RLLFYKY++K+YR  K RG+IIE EGD P     IEMDGK++NSH
Sbjct: 239 FFFPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKG---IEMDGKMMNSH 295

Query: 300 VENFLDGALV-LEVDERDQDDEEARREMARILKELKQKHPDKEIEQLIELANYQVLSQQQ 358
              FLDG LV LE  E D    E+RREM RILK+LKQKHP+K+++QL+E+ANY  LS QQ
Sbjct: 296 ---FLDGNLVPLEGKEVD----ESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQ 348

Query: 359 KSRAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVTENDPVSKIFFEQGTYQC 418
           KSRAFYRIQATR+MTGAGNILK+HAA+QA+KA SM EV+T+  E D +SK+FF+  +YQC
Sbjct: 349 KSRAFYRIQATRMMTGAGNILKKHAAEQAKKASSMSEVHTDEPE-DFISKVFFDPCSYQC 407

Query: 419 LENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVG 478
           LENCG V LT++R+GGD++ T++VD++TEDG+ANAG+DYEFTEGTVV KPG+TQKE  VG
Sbjct: 408 LENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVG 467

Query: 479 IIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVST---LACLGSPSTATVTIFDDD 535
           IIDDDIFEEDE+F V LSNV++  E  E+G+  A   S     A L SP  ATVTI DDD
Sbjct: 468 IIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDD 527

Query: 536 HAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGEL 595
           HAGIFTFE    HVSESIG+MEVKVLRTSGARG VIVP++T+EGTA+GGGEDFEDT GEL
Sbjct: 528 HAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGEL 587

Query: 596 EFQNDEIVKIITIRIFDREEYEKECSFSLVLEEPKWIRRGMKGGFTITDEYDDKQPLTSK 655
           EF+NDE VK I ++I D EEYE++ +F + L EPKW+ RG+       D     + LT +
Sbjct: 588 EFKNDETVKTIRVKIVDEEEYERQENFFIALGEPKWMERGISALLLSPD-----RKLTME 642

Query: 656 EEEERRIAEMGRPILGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTNSWREQFIEA 715
           EEE +RIAEMG+P+LGEH KLEVIIEESYEFK+TVDKLIKKTNLALVVGT+SWR+QF+EA
Sbjct: 643 EEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFMEA 702

Query: 716 ITVSAGEDDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWNGWACFIVSILMI 775
           ITVSA  D+D+DE GEE+LPSCFDYVMHFLTVFWKVLFA VPPTEY +GWACF VSIL+I
Sbjct: 703 ITVSAAGDEDEDESGEERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSILII 762

Query: 776 GLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVT 835
           G+LTA IGDLASHFGCTIGLKDSVTAVVFVA GTSVPDTFASK AA QD YADASIGNVT
Sbjct: 763 GMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVT 822

Query: 836 GSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTLFTIFAFINVGVLLYRRRP 895
           GSNAVNVFLGIG+AWS+AAIY A  G++F VS GTLAFSVTLFTIFAF+ + VLLYRRRP
Sbjct: 823 GSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRRP 882

Query: 896 EIGGELGGPRTAKLLTSCLFVLLWLLYIFFSSLEAYCHIKGF 937
            +GGELGGPR  KL T+ LFV LWLLYI F++LEAYC+IKGF
Sbjct: 883 HLGGELGGPRGCKLATTWLFVSLWLLYILFATLEAYCYIKGF 924


>gi|15147254 solute carrier family 8 (sodium/calcium exchanger),
           member 3 isoform A precursor [Homo sapiens]
          Length = 925

 Score = 1306 bits (3380), Expect = 0.0
 Identities = 663/942 (70%), Positives = 777/942 (82%), Gaps = 25/942 (2%)

Query: 4   MRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIAETEMEGEGNETGE----CTGSYYCKKGV 59
           M  L L P  S   H  +   +LF  ++ + AE    G+   TG+    C+GS  CK+GV
Sbjct: 1   MAWLRLQPLTSAFLHFGLVTFVLF--LNGLRAEAGGSGDVPSTGQNNESCSGSSDCKEGV 58

Query: 60  ILPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPN 119
           ILPIW P++PS GDKIAR  VYFVA++YMFLGVSIIADRFM+SIEVITSQE+E+TIKKPN
Sbjct: 59  ILPIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPN 118

Query: 120 GETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNM 179
           GET+ TT+R+WNETVSNLTLMALGSSAPEILLS+IEVCGH F AGDLGPSTIVGSAAFNM
Sbjct: 119 GETSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNM 178

Query: 180 FIIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTF 239
           FIII +CVYV+PDGETRKIKHLRVFF+TAAWSIFAY WLY+IL+V SPGVV+VWEGLLT 
Sbjct: 179 FIIIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTL 238

Query: 240 FFFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSH 299
           FFFP+CV+ AWVAD+RLLFYKY++K+YR  K RG+IIE EGD P     IEMDGK++NSH
Sbjct: 239 FFFPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKG---IEMDGKMMNSH 295

Query: 300 VENFLDGALV-LEVDERDQDDEEARREMARILKELKQKHPDKEIEQLIELANYQVLSQQQ 358
              FLDG LV LE  E D    E+RREM RILK+LKQKHP+K+++QL+E+ANY  LS QQ
Sbjct: 296 ---FLDGNLVPLEGKEVD----ESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQ 348

Query: 359 KSRAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVTENDPVSKIFFEQGTYQC 418
           KSRAFYRIQATR+MTGAGNILK+HAA+QA+KA SM EV+T+  E D +SK+FF+  +YQC
Sbjct: 349 KSRAFYRIQATRMMTGAGNILKKHAAEQAKKASSMSEVHTDEPE-DFISKVFFDPCSYQC 407

Query: 419 LENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVG 478
           LENCG V LT++R+GGD++ T++VD++TEDG+ANAG+DYEFTEGTVV KPG+TQKE  VG
Sbjct: 408 LENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVG 467

Query: 479 IIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVST---LACLGSPSTATVTIFDDD 535
           IIDDDIFEEDE+F V LSNV++  E  E+G+  A   S     A L SP  ATVTI DDD
Sbjct: 468 IIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDD 527

Query: 536 HAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGEL 595
           HAGIFTFE    HVSESIG+MEVKVLRTSGARG VIVP++T+EGTA+GGGEDFEDT GEL
Sbjct: 528 HAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGEL 587

Query: 596 EFQNDEIVKIITIRIFDREEYEKECSFSLVLEEPKWIRRGMKGGFTITDEYDDKQPLTSK 655
           EF+NDE VK I I++ D E YEK  ++ + +  P+ +    +    ++ +    + LT +
Sbjct: 588 EFKNDETVKTIHIKVIDDEAYEKNKNYFIEMMGPRMVDMSFQKALLLSPD----RKLTME 643

Query: 656 EEEERRIAEMGRPILGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTNSWREQFIEA 715
           EEE +RIAEMG+P+LGEH KLEVIIEESYEFK+TVDKLIKKTNLALVVGT+SWR+QF+EA
Sbjct: 644 EEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFMEA 703

Query: 716 ITVSAGEDDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWNGWACFIVSILMI 775
           ITVSA  D+D+DE GEE+LPSCFDYVMHFLTVFWKVLFA VPPTEY +GWACF VSIL+I
Sbjct: 704 ITVSAAGDEDEDESGEERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSILII 763

Query: 776 GLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVT 835
           G+LTA IGDLASHFGCTIGLKDSVTAVVFVA GTSVPDTFASK AA QD YADASIGNVT
Sbjct: 764 GMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVT 823

Query: 836 GSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTLFTIFAFINVGVLLYRRRP 895
           GSNAVNVFLGIG+AWS+AAIY A  G++F VS GTLAFSVTLFTIFAF+ + VLLYRRRP
Sbjct: 824 GSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRRP 883

Query: 896 EIGGELGGPRTAKLLTSCLFVLLWLLYIFFSSLEAYCHIKGF 937
            +GGELGGPR  KL T+ LFV LWLLYI F++LEAYC+IKGF
Sbjct: 884 HLGGELGGPRGCKLATTWLFVSLWLLYILFATLEAYCYIKGF 925


>gi|57163987 solute carrier family 8 member 2 [Homo sapiens]
          Length = 921

 Score = 1216 bits (3146), Expect = 0.0
 Identities = 605/894 (67%), Positives = 731/894 (81%), Gaps = 14/894 (1%)

Query: 46  TGECTGSYYCKKGVILPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEV 105
           TG C GSY C+ GV+LP+WEP DPS GDK ARA VYFVAMVYMFLGVSIIADRFM++IEV
Sbjct: 40  TGGCQGSYRCQPGVLLPVWEPDDPSLGDKAARAVVYFVAMVYMFLGVSIIADRFMAAIEV 99

Query: 106 ITSQEKEITIKKPNGETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGD 165
           ITS+EKEITI K NGET+  TVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNF AG+
Sbjct: 100 ITSKEKEITITKANGETSVGTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFQAGE 159

Query: 166 LGPSTIVGSAAFNMFIIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVI 225
           LGP TIVGSAAFNMF++IA+C+YV+P GE+RKIKHLRVFFVTA+WSIFAY WLY+IL+V 
Sbjct: 160 LGPGTIVGSAAFNMFVVIAVCIYVIPAGESRKIKHLRVFFVTASWSIFAYVWLYLILAVF 219

Query: 226 SPGVVEVWEGLLTFFFFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSS 285
           SPGVV+VWE LLT  FFP+CVVFAW+AD+RLLFYKYVYKRYR   + G+II  EGD P S
Sbjct: 220 SPGVVQVWEALLTLVFFPVCVVFAWMADKRLLFYKYVYKRYRTDPRSGIIIGAEGDPPKS 279

Query: 286 KTEIEMDGKVVNSHVENFLDGALVLEVDERDQDDEEARREMARILKELKQKHPDKEIEQL 345
              IE+DG  V +     L G      + R+ D   +RRE+ +ILK+LKQKHPDK++EQL
Sbjct: 280 ---IELDGTFVGAEAPGELGGLGPGPAEARELD--ASRREVIQILKDLKQKHPDKDLEQL 334

Query: 346 IELANYQVLSQQQKSRAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVTENDP 405
           + +ANY  L  QQKSRAFYRIQATRLMTGAGN+L+RHAAD +R+A        +  E+D 
Sbjct: 335 VGIANYYALLHQQKSRAFYRIQATRLMTGAGNVLRRHAADASRRAAPAEGAGED--EDDG 392

Query: 406 VSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVV 465
            S+IFFE   Y CLENCG+V L++  +GG+  +T +VD+RTEDG+A AGSDYE++EGT+V
Sbjct: 393 ASRIFFEPSLYHCLENCGSVLLSVTCQGGEGNSTFYVDYRTEDGSAKAGSDYEYSEGTLV 452

Query: 466 FKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVS-TLACLGSP 524
           FKPG+TQKE+R+GIIDDDIFEEDE+F V L N++V       G+ E +        L +P
Sbjct: 453 FKPGETQKELRIGIIDDDIFEEDEHFFVRLLNLRV---GDAQGMFEPDGGGRPKGRLVAP 509

Query: 525 STATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGG 584
             ATVTI DDDHAGIF+F++ + HVSE +G ++V+V+R+SGARG V +PY+T++GTARGG
Sbjct: 510 LLATVTILDDDHAGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTVRLPYRTVDGTARGG 569

Query: 585 GEDFEDTCGELEFQNDEIVKIITIRIFDREEYEKECSFSLVLEEPKWIRRGMKGGFTITD 644
           G  +ED CGELEF +DE +K + ++I D EEYEK+ +F + L +P+W++RG+     + +
Sbjct: 570 GVHYEDACGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIELGQPQWLKRGISA--LLLN 627

Query: 645 EYDDKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVG 704
           + D  + LT++EEE RRIAEMG+P+LGE+ +LEVIIEESY+FK+TVDKLIKKTNLALV+G
Sbjct: 628 QGDGDRKLTAEEEEARRIAEMGKPVLGENCRLEVIIEESYDFKNTVDKLIKKTNLALVIG 687

Query: 705 TNSWREQFIEAITVSAG-EDDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWN 763
           T+SWREQF+EAITVSAG E++++D   EE+LPSCFDYVMHFLTVFWKVLFA VPPTEY +
Sbjct: 688 THSWREQFLEAITVSAGDEEEEEDGSREERLPSCFDYVMHFLTVFWKVLFACVPPTEYCH 747

Query: 764 GWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQ 823
           GWACF VSIL+IGLLTA IGDLASHFGCT+GLKDSV AVVFVALGTS+PDTFASKVAA Q
Sbjct: 748 GWACFGVSILVIGLLTALIGDLASHFGCTVGLKDSVNAVVFVALGTSIPDTFASKVAALQ 807

Query: 824 DQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTLFTIFAF 883
           DQ ADASIGNVTGSNAVNVFLG+GVAWS+AA+Y A  G  F+V  GTLAFSVTLFT+FAF
Sbjct: 808 DQCADASIGNVTGSNAVNVFLGLGVAWSVAAVYWAVQGRPFEVRTGTLAFSVTLFTVFAF 867

Query: 884 INVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWLLYIFFSSLEAYCHIKGF 937
           + + VLLYRRRP IGGELGGPR  KL T+ LF+ LWLLYI F+SLEAYCHI+GF
Sbjct: 868 VGIAVLLYRRRPHIGGELGGPRGPKLATTALFLGLWLLYILFASLEAYCHIRGF 921


>gi|194354001 solute carrier family 8 (sodium/calcium exchanger),
           member 3 isoform G [Homo sapiens]
          Length = 298

 Score =  475 bits (1223), Expect = e-134
 Identities = 237/296 (80%), Positives = 263/296 (88%), Gaps = 2/296 (0%)

Query: 642 ITDEYDDKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIEESYEFKSTVDKLIKKTNLAL 701
           I+D  D K  LT +EEE +RIAEMG+P+LGEH KLEVIIEESYEFK+TVDKLIKKTNLAL
Sbjct: 5   ISDVTDRK--LTMEEEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKTTVDKLIKKTNLAL 62

Query: 702 VVGTNSWREQFIEAITVSAGEDDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEY 761
           VVGT+SWR+QF+EAITVSA  D+D+DE GEE+LPSCFDYVMHFLTVFWKVLFA VPPTEY
Sbjct: 63  VVGTHSWRDQFMEAITVSAAGDEDEDESGEERLPSCFDYVMHFLTVFWKVLFACVPPTEY 122

Query: 762 WNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAA 821
            +GWACF VSIL+IG+LTA IGDLASHFGCTIGLKDSVTAVVFVA GTSVPDTFASK AA
Sbjct: 123 CHGWACFAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAA 182

Query: 822 TQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTLFTIF 881
            QD YADASIGNVTGSNAVNVFLGIG+AWS+AAIY A  G++F VS GTLAFSVTLFTIF
Sbjct: 183 LQDVYADASIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIF 242

Query: 882 AFINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWLLYIFFSSLEAYCHIKGF 937
           AF+ + VLLYRRRP +GGELGGPR  KL T+ LFV LWLLYI F++LEAYC+IKGF
Sbjct: 243 AFVCISVLLYRRRPHLGGELGGPRGCKLATTWLFVSLWLLYILFATLEAYCYIKGF 298


>gi|33946308 solute carrier family 8 (sodium/calcium exchanger),
           member 3 isoform F [Homo sapiens]
          Length = 284

 Score =  471 bits (1212), Expect = e-132
 Identities = 231/283 (81%), Positives = 256/283 (90%)

Query: 655 KEEEERRIAEMGRPILGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTNSWREQFIE 714
           +EEE +RIAEMG+P+LGEH KLEVIIEESYEFK+TVDKLIKKTNLALVVGT+SWR+QF+E
Sbjct: 2   EEEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFME 61

Query: 715 AITVSAGEDDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWNGWACFIVSILM 774
           AITVSA  D+D+DE GEE+LPSCFDYVMHFLTVFWKVLFA VPPTEY +GWACF VSIL+
Sbjct: 62  AITVSAAGDEDEDESGEERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSILI 121

Query: 775 IGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNV 834
           IG+LTA IGDLASHFGCTIGLKDSVTAVVFVA GTSVPDTFASK AA QD YADASIGNV
Sbjct: 122 IGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNV 181

Query: 835 TGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTLFTIFAFINVGVLLYRRR 894
           TGSNAVNVFLGIG+AWS+AAIY A  G++F VS GTLAFSVTLFTIFAF+ + VLLYRRR
Sbjct: 182 TGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRR 241

Query: 895 PEIGGELGGPRTAKLLTSCLFVLLWLLYIFFSSLEAYCHIKGF 937
           P +GGELGGPR  KL T+ LFV LWLLYI F++LEAYC+IKGF
Sbjct: 242 PHLGGELGGPRGCKLATTWLFVSLWLLYILFATLEAYCYIKGF 284


>gi|113722120 G protein-coupled receptor 98 precursor [Homo sapiens]
          Length = 6306

 Score = 84.3 bits (207), Expect = 5e-16
 Identities = 66/233 (28%), Positives = 110/233 (47%), Gaps = 6/233 (2%)

Query: 398  TEVTENDPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDY 457
            T V  + P  +  F     +  E    V +TIIR  GD  + V + ++T  GTA AG D+
Sbjct: 4258 TVVASDSPYGRFAFSHEQLRVSE-AQRVNITIIRSSGDFGH-VRLWYKTMSGTAEAGLDF 4315

Query: 458  EFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEAN-HVS 516
                G ++F+ G+ +K + V I+DDD  E  E F + ++ V++     +  I E    + 
Sbjct: 4316 VPAAGELLFEAGEMRKSLHVEILDDDYPEGPEEFSLTITKVELQGRGYDFTIQENGLQID 4375

Query: 517  TLACLGSPSTATVTIFDDDHA-GIFTFEEPVT--HVSESIGIMEVKVLRTSGARGNVIVP 573
                +G+ S   + I  +D+A GI  F+   T   V E +G++ + V+R  G  G V   
Sbjct: 4376 QPPEIGNISIVRIIIMKNDNAEGIIEFDPKYTAFEVEEDVGLIMIPVVRLHGTYGYVTAD 4435

Query: 574  YKTIEGTARGGGEDFEDTCGELEFQNDEIVKIITIRIFDREEYEKECSFSLVL 626
            + +   +A  GG D+      + FQ+ + +  I I I D  E E E    ++L
Sbjct: 4436 FISQSSSASPGGVDYILHGSTVTFQHGQNLSFINISIIDDNESEFEEPIEILL 4488



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 67/221 (30%), Positives = 100/221 (45%), Gaps = 21/221 (9%)

Query: 420  ENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGI 479
            E  G + L +IR  G L   V  +FRT   TA +  DY+   GT+ F+PG+  K I + I
Sbjct: 1734 EEDGEIRLLVIRAQG-LLGRVTAEFRTVSLTAFSPEDYQNVAGTLEFQPGERYKYIFINI 1792

Query: 480  IDDDIFEEDENFLVHLSNV--------KVSSEASEDGILE--ANHVSTLACLGSPSTATV 529
             D+ I E +++F V L N+        +V    S DG +E     +   A LG  S   V
Sbjct: 1793 TDNSIPELEKSFKVELLNLEGGVAELFRVDGSGSGDGDMEFFLPTIHKRASLGVASQILV 1852

Query: 530  TIFDDDHA-GIFTFEEPVTHVS-----ESIGIMEVKVLRTSGARGNVIVPYKTIEGTARG 583
            TI   DHA G+F F      VS     +    + + V+R  G    V + +  I+    G
Sbjct: 1853 TIAASDHAHGVFEFSPESLFVSGTEPEDGYSTVTLNVIRHHGTLSPVTLHW-NIDSDPDG 1911

Query: 584  GGEDFEDTCGELEFQNDEIVKIITIRIFDREEYEKECSFSL 624
               D   T G + F+  +    IT+ I   E+ E + +FS+
Sbjct: 1912 ---DLAFTSGNITFEIGQTSANITVEILPDEDPELDKAFSV 1949



 Score = 69.3 bits (168), Expect = 2e-11
 Identities = 70/261 (26%), Positives = 105/261 (40%), Gaps = 34/261 (13%)

Query: 410 FFEQGTYQCLENCGTVALTIIRRGGDLTN-TVFVDFRTEDGTANAGSDYEFTEGTVVFKP 468
           F  Q  +   E   TV   II R G+  N T  V    ED       D+  T        
Sbjct: 35  FTGQTEFVVNETSTTVIRLIIERIGEPANVTAIVSLYGEDA-----GDFFDTYAAAFIPA 89

Query: 469 GDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTAT 528
           G+T + + + + DDD+ E DE F+ HL+  K S+                  LG P T T
Sbjct: 90  GETNRTVYIAVCDDDLPEPDETFIFHLTLQKPSANVK---------------LGWPRTVT 134

Query: 529 VTIFDDDHA-GIFTFEE-PVTHVSESIG---IMEVKVLRTSGARGNVIVPYKTIEGTARG 583
           VTI  +D+A GI +F   P   VSE  G    M + ++R  G  G V+V ++ +EG    
Sbjct: 135 VTILSNDNAFGIISFNMLPSIAVSEPKGRNESMPLTLIREKGTYGMVMVTFE-VEGGPNP 193

Query: 584 GGEDFEDTCGELEFQNDEIVKIITIRIFDREEYEKECSFSLVLEEPKWIRRGMKGGFTIT 643
             ED     G + F       I  + + D E  E +  F + L       + ++GG  I 
Sbjct: 194 PDEDLSPVKGNITFPPGRATVIYNLTVLDDEVPENDEIFLIQL-------KSVEGGAEIN 246

Query: 644 DEYDDKQPLTSKEEEERRIAE 664
              +  + +  K +   R  +
Sbjct: 247 TSRNSIEIIIKKNDSPVRFLQ 267



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 66/230 (28%), Positives = 101/230 (43%), Gaps = 40/230 (17%)

Query: 420  ENCGTVALTIIRRGGDLTNTVFVDFRTE-------DGTANAGSDYEFTEGTVVFKPGDTQ 472
            EN  T+ L I R  G L   + +  R +       D  A    DY   E  ++ K    +
Sbjct: 3793 ENTTTLQLQIARDKG-LLGDIAIHLRAQPNFLLHVDNQATENEDYVLQETIIIMKENIKE 3851

Query: 473  KEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPST------ 526
                V I+ DD+ E +E F+V               I E N V++    G PS       
Sbjct: 3852 AHAEVSILPDDLPELEEGFIV--------------TITEVNLVNSDFSTGQPSVRRPGME 3897

Query: 527  -ATVTIFD-DDHAGIFTFE------EPVT--HVSESIGIMEVKVLRTSGARGNVIVPYKT 576
             A + I + DD  GIF F       E +T   V   + +++V V+R +G+ G V V +K 
Sbjct: 3898 IAEIMIEENDDPRGIFMFHVTRGAGEVITAYEVPPPLNVLQVPVVRLAGSFGAVNVYWKA 3957

Query: 577  IEGTARGGGEDFEDTCGELEFQNDEIVKIITIRIFDREEYEKECSFSLVL 626
               +A  G EDF+ + G LEF + ++  +I I I D  E+E   +F++ L
Sbjct: 3958 SPDSA--GLEDFKPSHGILEFADKQVTAMIEITIIDDAEFELTETFNISL 4005



 Score = 64.3 bits (155), Expect = 5e-10
 Identities = 63/228 (27%), Positives = 92/228 (40%), Gaps = 27/228 (11%)

Query: 420  ENCGTVALTIIRRGG--DLTNTVFVDFRTE-DGTANAGSDYEFTEGTVVFKPGDTQKEIR 476
            E   T++  + R  G  D  +  +   + E DG      D+    GT+ F P    + + 
Sbjct: 1587 EEGSTISCVVERTRGALDYVHVFYTISQIETDGINYLVDDFANASGTITFLPWQRSEVLN 1646

Query: 477  VGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDH 536
            + ++DDDI E +E F      V + S    DG L +   S  +      T  +TI   DH
Sbjct: 1647 IYVLDDDIPELNEYF-----RVTLVSAIPGDGKLGSTPTSGASIDPEKETTDITIKASDH 1701

Query: 537  A-GIFTFEE-----------------PVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIE 578
              G+  F                   P   V E  G + + V+R  G  G V   ++T+ 
Sbjct: 1702 PYGLLQFSTGLPPQPKDAMTLPASSVPHITVEEEDGEIRLLVIRAQGLLGRVTAEFRTVS 1761

Query: 579  GTARGGGEDFEDTCGELEFQNDEIVKIITIRIFDREEYEKECSFSLVL 626
             TA    ED+++  G LEFQ  E  K I I I D    E E SF + L
Sbjct: 1762 LTA-FSPEDYQNVAGTLEFQPGERYKYIFINITDNSIPELEKSFKVEL 1808



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 61/199 (30%), Positives = 85/199 (42%), Gaps = 33/199 (16%)

Query: 449  GTANAGSDYE-FTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFL-----VHLSNVKVSS 502
            G A AGSDYE  T    + + GD    + V I+ DD  E DE+FL     VHL N+  S 
Sbjct: 2495 GQAVAGSDYEPVTRQWAIMQEGDEFANLTVSILPDDFPEMDESFLISLLEVHLMNISAS- 2553

Query: 503  EASEDGILEANHVSTLACLGSPSTATVTI-FDDDHAGIFTFEEPVTHVSES--------- 552
                        +     +G P+ +TV I  + D  G+F       + SE          
Sbjct: 2554 ------------LKNQPTIGQPNISTVVIALNGDAFGVFVIYNISPNTSEDGLFVEVQEQ 2601

Query: 553  -IGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKIITIRIF 611
               ++E+ + RT G+ G V V ++ + GTA   G DF      L F   E  K + + I 
Sbjct: 2602 PQTLVELMIHRTGGSLGQVAVEWRVVGGTAT-EGLDFIGAGEILTFAEGETKKTVILTIL 2660

Query: 612  DREEYEKECSF--SLVLEE 628
            D  E E + S   SLV  E
Sbjct: 2661 DDSEPEDDESIIVSLVYTE 2679



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 63/223 (28%), Positives = 102/223 (45%), Gaps = 25/223 (11%)

Query: 423  GTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDD 482
            GT  ++++R G  +   V V +R    +     ++  T G +  +   +   + +  ++D
Sbjct: 4171 GTAIISLVR-GPGILGEVTVFWRIFPPSVG---EFAETSGKLTMRDEQSAVIVVIQALND 4226

Query: 483  DIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHA-GIFT 541
            DI EE   +   L+ V      SE G+L            S STA +T+   D   G F 
Sbjct: 4227 DIPEEKSFYEFQLTAV------SEGGVLSE----------SSSTANITVVASDSPYGRFA 4270

Query: 542  FEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDE 601
            F      VSE+  +  + ++R+SG  G+V + YKT+ GTA  G  DF    GEL F+  E
Sbjct: 4271 FSHEQLRVSEAQRV-NITIIRSSGDFGHVRLWYKTMSGTAEAG-LDFVPAAGELLFEAGE 4328

Query: 602  IVKIITIRIFDREEYEKECSFSLVLEEPKWIRRGMKGGFTITD 644
            + K + + I D +  E    FSL + + +   RG    FTI +
Sbjct: 4329 MRKSLHVEILDDDYPEGPEEFSLTITKVELQGRGY--DFTIQE 4369



 Score = 60.8 bits (146), Expect = 6e-09
 Identities = 58/204 (28%), Positives = 92/204 (45%), Gaps = 22/204 (10%)

Query: 425  VALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDI 484
            V L I R GG L   V V++R   GTA  G D+      + F  G+T+K + + I+DD  
Sbjct: 2606 VELMIHRTGGSL-GQVAVEWRVVGGTATEGLDFIGAGEILTFAEGETKKTVILTILDDSE 2664

Query: 485  FEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDH-AGIFTFE 543
             E+DE+ +V L   +  S                  L S  T  V I  +D+ AGI +F+
Sbjct: 2665 PEDDESIIVSLVYTEGGSR----------------ILPSSDTVRVNILANDNVAGIVSFQ 2708

Query: 544  EPVTHVSESIG-IMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEI 602
                 V    G I++  V+RT   RGNV V +K I    +    +F +  G+L F    +
Sbjct: 2709 TASRSVIGHEGEILQFHVIRTFPGRGNVTVNWKII---GQNLELNFANFSGQLFFPEGSL 2765

Query: 603  VKIITIRIFDREEYEKECSFSLVL 626
               + + + D    E++  + ++L
Sbjct: 2766 NTTLFVHLLDDNIPEEKEVYQVIL 2789



 Score = 60.5 bits (145), Expect = 7e-09
 Identities = 65/247 (26%), Positives = 98/247 (39%), Gaps = 27/247 (10%)

Query: 398  TEVTENDPVSKIFFEQGT--YQCLENCGTVALTIIRRGGDLTNTVFVDFRTED------- 448
            T +  +DP     F +     +  E    + L+IIR  G L   V V + T D       
Sbjct: 1968 TVLASDDPYGIFIFSEKNRPVKVEEATQNITLSIIRLKG-LMGKVLVSYATLDDMEKPPY 2026

Query: 449  -----GTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSN----VK 499
                   A  G DY    G  +F    ++  I + I+DDD  E  E+  + L N     K
Sbjct: 2027 FPPNLARATQGRDYIPASGFALFGANQSEATIAISILDDDEPERSESVFIELLNSTLVAK 2086

Query: 500  VSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVK 559
            V S +  +       V T+A L       + I +DD  G      P+  V+E+     + 
Sbjct: 2087 VQSRSIPNSPRLGPKVETIAQL-------IIIANDDAFGTLQLSAPIVRVAENHVGPIIN 2139

Query: 560  VLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKIITIRIFDREEYEKE 619
            V RT GA  +V V +K +  TA   GED+     ++     E  K + I + +    E E
Sbjct: 2140 VTRTGGAFADVSVKFKAVPITAI-AGEDYSIASSDVVLLEGETSKAVPIYVINDIYPELE 2198

Query: 620  CSFSLVL 626
             SF + L
Sbjct: 2199 ESFLVQL 2205



 Score = 57.4 bits (137), Expect = 6e-08
 Identities = 60/218 (27%), Positives = 92/218 (42%), Gaps = 38/218 (17%)

Query: 424  TVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDD 483
            TV L +IR  G L+  V + +  +   ++   D  FT G + F+ G T   I V I+ D+
Sbjct: 1884 TVTLNVIRHHGTLS-PVTLHWNID---SDPDGDLAFTSGNITFEIGQTSANITVEILPDE 1939

Query: 484  IFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIF-DDDHAGIFTF 542
              E D+ F V + +V   S                  LG+   AT+T+   DD  GIF F
Sbjct: 1940 DPELDKAFSVSVLSVSSGS------------------LGAHINATLTVLASDDPYGIFIF 1981

Query: 543  EE---PVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTAR-----------GGGEDF 588
             E   PV  V E+   + + ++R  G  G V+V Y T++   +             G D+
Sbjct: 1982 SEKNRPV-KVEEATQNITLSIIRLKGLMGKVLVSYATLDDMEKPPYFPPNLARATQGRDY 2040

Query: 589  EDTCGELEFQNDEIVKIITIRIFDREEYEKECSFSLVL 626
                G   F  ++    I I I D +E E+  S  + L
Sbjct: 2041 IPASGFALFGANQSEATIAISILDDDEPERSESVFIEL 2078



 Score = 57.4 bits (137), Expect = 6e-08
 Identities = 54/190 (28%), Positives = 82/190 (43%), Gaps = 26/190 (13%)

Query: 427  LTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDIFE 486
            + + R GG   + V V F+    TA AG DY      VV   G+T K + + +I+D   E
Sbjct: 2138 INVTRTGGAFAD-VSVKFKAVPITAIAGEDYSIASSDVVLLEGETSKAVPIYVINDIYPE 2196

Query: 487  EDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTI-FDDDHAGIFTFEEP 545
             +E+FLV L N                     A LG+ + A + I   DD  G+F F+  
Sbjct: 2197 LEESFLVQLMNETTGG----------------ARLGALTEAVIIIEASDDPYGLFGFQIT 2240

Query: 546  VTHVSE----SIGIMEVKVLRTSGARGNVIVPY-KTIEGTARGGGEDFEDTCGELEFQND 600
               V E    S+ +  + ++R SG  GNV V +  TI G    G  D     G + F   
Sbjct: 2241 KLIVEEPEFNSVKV-NLPIIRNSGTLGNVTVQWVATINGQLATG--DLRVVSGNVTFAPG 2297

Query: 601  EIVKIITIRI 610
            E ++ + + +
Sbjct: 2298 ETIQTLLLEV 2307



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 55/194 (28%), Positives = 86/194 (44%), Gaps = 23/194 (11%)

Query: 423  GTVALTIIRRGGDLTNTVFVDFRTEDGTANAGS-DYEFTE--GTVVFKPGDTQKEIRVGI 479
            G  A   + R G +  T  V + T+DG A A   D+   E   T++F+ G  Q+ I + +
Sbjct: 1017 GETANFTVLRNGSVDVTCMVQYATKDGKATARERDFIPVEKGETLIFEVGSRQQSISIFV 1076

Query: 480  IDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTI-FDDDHAG 538
             +D I E DE F + L N    +   + G+                 ATV I  +DD  G
Sbjct: 1077 NEDGIPETDEPFYIILLNSTGDTVVYQYGV-----------------ATVIIEANDDPNG 1119

Query: 539  IFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEG-TARGGGEDFEDTCGELEF 597
            IF+  EP+    E        +LR  G  G+V V ++  +  +A   G++F +T G + F
Sbjct: 1120 IFSL-EPIDKAVEEGKTNAFWILRHRGYFGSVSVSWQLFQNDSALQPGQEFYETSGTVNF 1178

Query: 598  QNDEIVKIITIRIF 611
             + E  K I +  F
Sbjct: 1179 MDGEEAKPIILHAF 1192



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 44/161 (27%), Positives = 72/161 (44%), Gaps = 27/161 (16%)

Query: 455  SDYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANH 514
            SD+  + G ++F+PG+ +  I V I+DD + E++E+F V L N K  +E           
Sbjct: 3585 SDFIPSSGELIFEPGEREATIAVNILDDTVPEKEESFKVQLKNPKGGAE----------- 3633

Query: 515  VSTLACLGSPSTATVTIFDDDHA-GIFTFEEPVTHVS----ESIGIMEVKVLRTSGARGN 569
                  +G   + T+TI  +D A GI  F +   +      E   ++ + V R  G  G 
Sbjct: 3634 ------IGINDSVTITILSNDDAYGIVAFAQNSLYKQVEEMEQDSLVTLNVERLKGTYGR 3687

Query: 570  VIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKIITIRI 610
            +     TI   A G   D   T G + F   +++  IT+ I
Sbjct: 3688 I-----TIAWEADGSISDIFPTSGVILFTEGQVLSTITLTI 3723



 Score = 54.3 bits (129), Expect = 5e-07
 Identities = 52/221 (23%), Positives = 90/221 (40%), Gaps = 8/221 (3%)

Query: 409  IFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKP 468
            I ++Q  ++  E  G++ L + +R  +    V +    ++  A  G DY FT   + F  
Sbjct: 2962 IEWQQSRFEVNETHGSLTL-VAQRSREPLGHVSLFVYAQNLEAQVGLDYIFTPMILHFAD 3020

Query: 469  GDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTAT 528
            G+  K + + I+DDDI E DE F + L+N     E      L  N ++ +  L +     
Sbjct: 3021 GERYKNVNIMILDDDIPEGDEKFQLILTNPSPGLE------LGKNTIALIIVLANDDGPG 3074

Query: 529  VTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDF 588
            V  F++     F  E    +V ES+ ++ +      G  G V V +   E  +    +D 
Sbjct: 3075 VLSFNNSE-HFFLREPTALYVQESVAVLYIVREPAQGLFGTVTVQFIVTEVNSSNESKDL 3133

Query: 589  EDTCGELEFQNDEIVKIITIRIFDREEYEKECSFSLVLEEP 629
              + G +  +     K + I      E E +  F   L  P
Sbjct: 3134 TPSKGYIVLEEGVRFKALQISAILDTEPEMDEYFVCTLFNP 3174



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 44/170 (25%), Positives = 75/170 (44%), Gaps = 12/170 (7%)

Query: 462  GTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACL 521
            G ++ + G+T   I + I++DD+ E +E FLV+L+ V         G+  A   S    L
Sbjct: 2891 GFLILEEGETAAAINITILEDDVPELEEYFLVNLTYV---------GLTMAASTSFPPRL 2941

Query: 522  GSPSTATVTIFD--DDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEG 579
             S       I D  D   G+  +++    V+E+ G + +   R+    G+V + +   + 
Sbjct: 2942 DSEGLTAQVIIDANDGARGVIEWQQSRFEVNETHGSLTLVAQRSREPLGHVSL-FVYAQN 3000

Query: 580  TARGGGEDFEDTCGELEFQNDEIVKIITIRIFDREEYEKECSFSLVLEEP 629
                 G D+  T   L F + E  K + I I D +  E +  F L+L  P
Sbjct: 3001 LEAQVGLDYIFTPMILHFADGERYKNVNIMILDDDIPEGDEKFQLILTNP 3050



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 42/174 (24%), Positives = 74/174 (42%), Gaps = 24/174 (13%)

Query: 406  VSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVV 465
            ++K+  E+  +  ++    V L IIR  G L N       T +G    G D     G V 
Sbjct: 2239 ITKLIVEEPEFNSVK----VNLPIIRNSGTLGNVTVQWVATINGQLATG-DLRVVSGNVT 2293

Query: 466  FKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPS 525
            F PG+T + + + ++ DD+ E +E   V L      ++AS  G +  + ++ +       
Sbjct: 2294 FAPGETIQTLLLEVLADDVPEIEEVIQVQL------TDASGGGTIGLDRIANI------- 2340

Query: 526  TATVTIFDDDHAGIFTFEEPVTHVSESI---GIMEVKVLRTSGARGNVIVPYKT 576
               +   +DD  G   F + V  V E +       + V R+ G  G +++ Y T
Sbjct: 2341 ---IIPANDDPYGTVAFAQMVYRVQEPLERSSCANITVRRSGGHFGRLLLFYST 2391



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 55/243 (22%), Positives = 93/243 (38%), Gaps = 39/243 (16%)

Query: 400  VTENDPVSKIFFEQGT---------YQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGT 450
            + END    IF    T         Y+       + + ++R  G     V V ++    +
Sbjct: 3903 IEENDDPRGIFMFHVTRGAGEVITAYEVPPPLNVLQVPVVRLAGSF-GAVNVYWKASPDS 3961

Query: 451  ANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGIL 510
            A    D++ + G + F        I + IIDD  FE  E F + L +V       +D ++
Sbjct: 3962 AGL-EDFKPSHGILEFADKQVTAMIEITIIDDAEFELTETFNISLISVAGGGRLGDDVVV 4020

Query: 511  EANHVSTLACLGSPSTATVTIFDDDHA-GIFTFEEPVTHVSESI------GIMEVKVLRT 563
                             TV I  +D   G+F FEE    + ES+        + + V+R+
Sbjct: 4021 -----------------TVVIPQNDSPFGVFGFEEKTVMIDESLSSDDPDSYVTLTVVRS 4063

Query: 564  SGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKIITIRIFDREEYEKECSFS 623
             G +G V + + TI+  A+    +     G L F   E  K I +        E++  F+
Sbjct: 4064 PGGKGTVRLEW-TIDEKAK---HNLSPLNGTLHFDETESQKTIVLHTLQDTVLEEDRRFT 4119

Query: 624  LVL 626
            + L
Sbjct: 4120 IQL 4122



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 62/266 (23%), Positives = 104/266 (39%), Gaps = 40/266 (15%)

Query: 392 SMHEVNTEVTENDPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVD-------- 443
           S + +   + +ND  S + F Q  Y   E    + + ++R   +  N +  D        
Sbjct: 248 SRNSIEIIIKKND--SPVRFLQSIYLVPEEDHILIIPVVRGKDNNGNLIGSDEYEVSISY 305

Query: 444 -FRTEDGTANAGSDYEFTE----GTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNV 498
              T + TA+A  + +F +     TVVF P   +  ++  I+DD I E  E+F + L   
Sbjct: 306 AVTTGNSTAHAQQNLDFIDLQPNTTVVFPPFIHESHLKFQIVDDTIPEIAESFHIMLLKD 365

Query: 499 KVSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHA-GIFT-----FEEPVTHVSES 552
            +  +               A L SPS   VTI  +D   G+ +     FE  V    + 
Sbjct: 366 TLQGD---------------AVLISPSVVQVTIKPNDKPYGVLSFNSVLFERTVIIDEDR 410

Query: 553 IG-IMEVKVLRTSGARGNVIVPYKTIEGTARGG--GEDFEDTCGELEFQNDEIVKIITIR 609
           I    E+ V+R  G  GNV   +     +        D   + G L F   +++  I + 
Sbjct: 411 ISRYEEITVVRNGGTHGNVSANWVLTRNSTDPSPVTADIRPSSGVLHFAQGQMLATIPLT 470

Query: 610 IFDREEYEKECSFSLVLEEPKWIRRG 635
           + D ++  +E    L+   P  IR G
Sbjct: 471 VVD-DDLPEEAEAYLLQILPHTIRGG 495



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 64/238 (26%), Positives = 98/238 (41%), Gaps = 36/238 (15%)

Query: 400 VTENDPVSKIF----FEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGS 455
           + END    +F      +G Y   E   +V L IIR  G L    F+ +R E   +N   
Sbjct: 766 ILENDDPGGVFEFSPASRGPYVIKEG-ESVELHIIRSRGSLVKQ-FLHYRVEPRDSN--- 820

Query: 456 DYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHV 515
           ++    G + FKPG+ +  I +    D I E DE++ V LS                +H 
Sbjct: 821 EFYGNTGVLEFKPGEREIVITLLARLDGIPELDEHYWVVLS----------------SHG 864

Query: 516 STLACLGSPSTATVTIF-DDDHAGIFTF--EEPVTHVSESIG----IMEVKVLRTSGARG 568
              + LGS +   +TI  +DD  GI  F  +  +  ++ES G         V+R  G  G
Sbjct: 865 ERESKLGSATIVNITILKNDDPHGIIEFVSDGLIVMINESKGDAIYSAVYDVVRNRGNFG 924

Query: 569 NVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKIITIRIFDREEYEKECSFSLVL 626
           +V V +           +D     G + F + E  K ITI     E  E+   F+++L
Sbjct: 925 DVSVSWVVSPDFT----QDVFPVQGTVVFGDQEFSKNITIYSLPDEIPEEMEEFTVIL 978



 Score = 40.4 bits (93), Expect = 0.008
 Identities = 56/225 (24%), Positives = 85/225 (37%), Gaps = 37/225 (16%)

Query: 453  AGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEA 512
            AG D  F E TV      T   +           +    L   + V + +EA+    +  
Sbjct: 5131 AGMDISFPETTVAVAVDTTLIPVETESTTYLSTSKTTTILQPTNVVAIVTEATGVSAIPE 5190

Query: 513  NHVS---TLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESI-----GIMEVKVLRTS 564
              V+   T A    P  ATVT     H G F+    + ++ E +        EV + RT 
Sbjct: 5191 KLVTLHGTPAVSEKPDVATVTANVSIH-GTFSLGPSIVYIEEEMKNGTFNTAEVLIRRTG 5249

Query: 565  GARGNVIV-----------------PYKTIEG----TARGGGEDFEDTCGELEFQNDEIV 603
            G  GNV +                 P++ I G    T     EDFE+    L F + E  
Sbjct: 5250 GFTGNVSITVKTFGERCAQMEPNALPFRGIYGISNLTWAVEEEDFEEQTLTLIFLDGERE 5309

Query: 604  KIITIRIFDREEYEKECSFSLVLEEPKWIRRGMKGGFTITDEYDD 648
            + ++++I D +E E +  F + L  P       +GG  I +E DD
Sbjct: 5310 RKVSVQILDDDEPEGQEFFYVFLTNP-------QGGAQIVEEKDD 5347



 Score = 40.0 bits (92), Expect = 0.010
 Identities = 47/180 (26%), Positives = 76/180 (42%), Gaps = 23/180 (12%)

Query: 453  AGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEA 512
            A SD     G + F+ G+T K   +   DD+  E +E F++ L +V   +  SE+     
Sbjct: 1503 AKSDLHPISGYLEFRQGETNKSFIISARDDNDEEGEELFILKLVSVYGGARISEEN---- 1558

Query: 513  NHVSTLACLGSPSTATVTIFDDDHA-GIFTFEEP-VTHVSESIGIMEVKVLRTSGARGNV 570
                        +TA +TI   D+A G+F F    +  ++E    +   V RT GA   V
Sbjct: 1559 ------------TTARLTIQKSDNANGLFGFTGACIPEIAEEGSTISCVVERTRGALDYV 1606

Query: 571  IVPYKTIEGTARGG----GEDFEDTCGELEFQNDEIVKIITIRIFDREEYEKECSFSLVL 626
             V Y TI      G     +DF +  G + F   +  +++ I + D +  E    F + L
Sbjct: 1607 HVFY-TISQIETDGINYLVDDFANASGTITFLPWQRSEVLNIYVLDDDIPELNEYFRVTL 1665



 Score = 38.5 bits (88), Expect = 0.030
 Identities = 45/186 (24%), Positives = 75/186 (40%), Gaps = 18/186 (9%)

Query: 425 VALTIIRRGGDLTNTVFVDFRTEDGTANAGS--DYEFTEGTVVFKPGDTQKEIRVGIIDD 482
           V + + R G D   TV+   +     + A +  D     G+V+F  G +   I + I  D
Sbjct: 673 VYIPLHRDGTDGQATVYWSLKPSGFNSKAVTPDDIGPFNGSVLFLSGQSDTTINITIKGD 732

Query: 483 DIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHAGIFTF 542
           DI E +E   + L  V V ++  + G                S   + + +DD  G+F F
Sbjct: 733 DIPEMNETVTLSLDRVNVENQVLKSGY--------------TSRDLIILENDDPGGVFEF 778

Query: 543 EEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEI 602
             P +     I   E   L    +RG+++  +       R   E + +T G LEF+  E 
Sbjct: 779 -SPASRGPYVIKEGESVELHIIRSRGSLVKQFLHYRVEPRDSNEFYGNT-GVLEFKPGER 836

Query: 603 VKIITI 608
             +IT+
Sbjct: 837 EIVITL 842



 Score = 37.7 bits (86), Expect = 0.051
 Identities = 52/238 (21%), Positives = 101/238 (42%), Gaps = 34/238 (14%)

Query: 396  VNTEVTENDPVSKIF-FEQGTYQCLENCGT------VALTIIRRGGDLTNTVFVDFRTED 448
            V   + +ND    +F FE+ T    E+  +      V LT++R  G    TV +++  ++
Sbjct: 4020 VTVVIPQNDSPFGVFGFEEKTVMIDESLSSDDPDSYVTLTVVRSPGG-KGTVRLEWTIDE 4078

Query: 449  GTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENF---LVHLSNVKVSSEAS 505
                A  +     GT+ F   ++QK I +  + D + EED  F   L+ +  V++S    
Sbjct: 4079 ---KAKHNLSPLNGTLHFDETESQKTIVLHTLQDTVLEEDRRFTIQLISIDEVEISPVKG 4135

Query: 506  EDGILEANHVSTLACLG-SPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTS 564
               I+          +G +PS+  + I            EP    +   G   + ++R  
Sbjct: 4136 SASIIIRGDKRASGEVGIAPSSRHILI-----------GEPSAKYN---GTAIISLVRGP 4181

Query: 565  GARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKIITIRIFDREEYEKECSF 622
            G  G V V ++    +      +F +T G+L  ++++   I+ I+  + ++  +E SF
Sbjct: 4182 GILGEVTVFWRIFPPSV----GEFAETSGKLTMRDEQSAVIVVIQALN-DDIPEEKSF 4234



 Score = 35.4 bits (80), Expect = 0.25
 Identities = 37/128 (28%), Positives = 52/128 (40%), Gaps = 19/128 (14%)

Query: 461  EGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLAC 520
            +GTVVF   +  K I +  + D+I EE E F V L N    ++                 
Sbjct: 944  QGTVVFGDQEFSKNITIYSLPDEIPEEMEEFTVILLNGTGGAK----------------- 986

Query: 521  LGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGT 580
            +G+ +TAT+ I  +D   I+  E  V  V E        VLR        +V Y T +G 
Sbjct: 987  VGNRTTATLRIRRNDDP-IYFAEPRVVRVQEG-ETANFTVLRNGSVDVTCMVQYATKDGK 1044

Query: 581  ARGGGEDF 588
            A     DF
Sbjct: 1045 ATARERDF 1052



 Score = 34.3 bits (77), Expect = 0.56
 Identities = 37/159 (23%), Positives = 63/159 (39%), Gaps = 25/159 (15%)

Query: 427 LTIIRRGGDLTNTV--FVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDI 484
           +T++R GG   N    +V  R     +   +D   + G + F  G     I + ++DDD+
Sbjct: 417 ITVVRNGGTHGNVSANWVLTRNSTDPSPVTADIRPSSGVLHFAQGQMLATIPLTVVDDDL 476

Query: 485 FEEDENFLVHL--SNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFD-DDHAGIFT 541
            EE E +L+ +    ++  +E SE                 P+     I D DD  G+ T
Sbjct: 477 PEEAEAYLLQILPHTIRGGAEVSE-----------------PAELLFYIQDSDDVYGLIT 519

Query: 542 F---EEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTI 577
           F   E      S     + +   R  G +G+V + Y  +
Sbjct: 520 FFPMENQKIESSPGERYLSLSFTRLGGTKGDVRLLYSVL 558



 Score = 32.0 bits (71), Expect = 2.8
 Identities = 39/166 (23%), Positives = 67/166 (40%), Gaps = 5/166 (3%)

Query: 480  IDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHAGI 539
            ID  I+E  ++   +  +V  ++         A+ ++ +  +G   +A      + +   
Sbjct: 3481 IDIFIWEMGQSSFRYFQSVDFAAVNRIHSFTPASGIAHILLIGQDMSALYCWNSERNQFS 3540

Query: 540  FTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTAR-GGGEDFEDTCGELEFQ 598
            F  E P  +    +  + VK L +S     ++  +  I   A      DF  + GEL F+
Sbjct: 3541 FVLEVPSAY---DVASVTVKSLNSSKNLIALVGAHSHIYELAYISSHSDFIPSSGELIFE 3597

Query: 599  NDEIVKIITIRIFDREEYEKECSFSLVLEEPK-WIRRGMKGGFTIT 643
              E    I + I D    EKE SF + L+ PK     G+    TIT
Sbjct: 3598 PGEREATIAVNILDDTVPEKEESFKVQLKNPKGGAEIGINDSVTIT 3643


>gi|169167211 PREDICTED: FRAS1 related extracellular matrix 3 [Homo
            sapiens]
          Length = 2139

 Score = 74.3 bits (181), Expect = 5e-13
 Identities = 78/274 (28%), Positives = 112/274 (40%), Gaps = 36/274 (13%)

Query: 409  IFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEF-TEGTVVFK 467
            I  E+  Y   E+   + +T+ RRG  L  T F+   T+D TA    D+++ T   + F 
Sbjct: 1775 ICLEKEYYIVDEDSTFLEVTLTRRGY-LGETSFISIGTKDETAKKDKDFKWKTNKQIQFN 1833

Query: 468  PGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTA 527
            PG T    RV II D+ +E  E F + LS                     +A L  P  A
Sbjct: 1834 PGQTTATWRVRIIPDNEYETSETFQIILSE------------------PLMAVLEFPEMA 1875

Query: 528  TVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGG--- 584
            TV I D          E    + E IG + + V R+  A   +IV   T +G+A G    
Sbjct: 1876 TVEIVDPGDESTVYIPEAEYKIEEDIGELLIPVRRSGDASQELIVICSTRQGSATGTISS 1935

Query: 585  ---GEDF----EDTCGELEFQNDEIVKIITIRIFDREEYEKECSFSLVLEEPKWIRRGMK 637
                 D+    ED    L F  +E  K   + I D   YE+E SFS+ L  P   + G +
Sbjct: 1936 TVLFSDYISRPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESFSVSLRLPVGGQLGAR 1995

Query: 638  GGFT----ITDEYDDKQPLTSKEEEERRIAEMGR 667
               T    + D YD  +P+    + E  + E  R
Sbjct: 1996 FPTTKVTILADRYD--EPVLHFGDAEYHVNESAR 2027



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 60/248 (24%), Positives = 98/248 (39%), Gaps = 34/248 (13%)

Query: 399  EVTENDPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAG---- 454
            E+ +    S ++  +  Y+  E+ G + + + RR GD +  + V   T  G+A       
Sbjct: 1878 EIVDPGDESTVYIPEAEYKIEEDIGELLIPV-RRSGDASQELIVICSTRQGSATGTISST 1936

Query: 455  ---SDY----EFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASED 507
               SDY    E     + F   +TQK  +V IIDD ++EE+E+F        VS      
Sbjct: 1937 VLFSDYISRPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESF-------SVSLRLPVG 1989

Query: 508  GILEANHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTS--- 564
            G L A           P+T    + D     +  F +   HV+ES   +EV V R     
Sbjct: 1990 GQLGARF---------PTTKVTILADRYDEPVLHFGDAEYHVNESARYVEVCVWRRGTDL 2040

Query: 565  GARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKIITIRIFD---REEYEKECS 621
                ++ V  +  E  +   G D+      L+F     ++   + I D   +   E    
Sbjct: 2041 SQPSSIAVRSRKSEQESAEAGTDYVGISRNLDFAPGVRMQTFQVTILDDLGQPTLEGPEK 2100

Query: 622  FSLVLEEP 629
            F L+L+ P
Sbjct: 2101 FELLLQMP 2108


>gi|169166904 PREDICTED: FRAS1 related extracellular matrix 3 [Homo
            sapiens]
          Length = 2139

 Score = 74.3 bits (181), Expect = 5e-13
 Identities = 78/274 (28%), Positives = 112/274 (40%), Gaps = 36/274 (13%)

Query: 409  IFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEF-TEGTVVFK 467
            I  E+  Y   E+   + +T+ RRG  L  T F+   T+D TA    D+++ T   + F 
Sbjct: 1775 ICLEKEYYIVDEDSTFLEVTLTRRGY-LGETSFISIGTKDETAKKDKDFKWKTNKQIQFN 1833

Query: 468  PGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTA 527
            PG T    RV II D+ +E  E F + LS                     +A L  P  A
Sbjct: 1834 PGQTTATWRVRIIPDNEYETSETFQIILSE------------------PLMAVLEFPEMA 1875

Query: 528  TVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGG--- 584
            TV I D          E    + E IG + + V R+  A   +IV   T +G+A G    
Sbjct: 1876 TVEIVDPGDESTVYIPEAEYKIEEDIGELLIPVRRSGDASQELIVICSTRQGSATGTISS 1935

Query: 585  ---GEDF----EDTCGELEFQNDEIVKIITIRIFDREEYEKECSFSLVLEEPKWIRRGMK 637
                 D+    ED    L F  +E  K   + I D   YE+E SFS+ L  P   + G +
Sbjct: 1936 TVLFSDYISRPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESFSVSLRLPVGGQLGAR 1995

Query: 638  GGFT----ITDEYDDKQPLTSKEEEERRIAEMGR 667
               T    + D YD  +P+    + E  + E  R
Sbjct: 1996 FPTTKVTILADRYD--EPVLHFGDAEYHVNESAR 2027



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 60/248 (24%), Positives = 98/248 (39%), Gaps = 34/248 (13%)

Query: 399  EVTENDPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAG---- 454
            E+ +    S ++  +  Y+  E+ G + + + RR GD +  + V   T  G+A       
Sbjct: 1878 EIVDPGDESTVYIPEAEYKIEEDIGELLIPV-RRSGDASQELIVICSTRQGSATGTISST 1936

Query: 455  ---SDY----EFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASED 507
               SDY    E     + F   +TQK  +V IIDD ++EE+E+F        VS      
Sbjct: 1937 VLFSDYISRPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESF-------SVSLRLPVG 1989

Query: 508  GILEANHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTS--- 564
            G L A           P+T    + D     +  F +   HV+ES   +EV V R     
Sbjct: 1990 GQLGARF---------PTTKVTILADRYDEPVLHFGDAEYHVNESARYVEVCVWRRGTDL 2040

Query: 565  GARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKIITIRIFD---REEYEKECS 621
                ++ V  +  E  +   G D+      L+F     ++   + I D   +   E    
Sbjct: 2041 SQPSSIAVRSRKSEQESAEAGTDYVGISRNLDFAPGVRMQTFQVTILDDLGQPTLEGPEK 2100

Query: 622  FSLVLEEP 629
            F L+L+ P
Sbjct: 2101 FELLLQMP 2108


>gi|169166334 PREDICTED: FRAS1 related extracellular matrix 3 [Homo
            sapiens]
          Length = 2139

 Score = 74.3 bits (181), Expect = 5e-13
 Identities = 78/274 (28%), Positives = 112/274 (40%), Gaps = 36/274 (13%)

Query: 409  IFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEF-TEGTVVFK 467
            I  E+  Y   E+   + +T+ RRG  L  T F+   T+D TA    D+++ T   + F 
Sbjct: 1775 ICLEKEYYIVDEDSTFLEVTLTRRGY-LGETSFISIGTKDETAKKDKDFKWKTNKQIQFN 1833

Query: 468  PGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTA 527
            PG T    RV II D+ +E  E F + LS                     +A L  P  A
Sbjct: 1834 PGQTTATWRVRIIPDNEYETSETFQIILSE------------------PLMAVLEFPEMA 1875

Query: 528  TVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGG--- 584
            TV I D          E    + E IG + + V R+  A   +IV   T +G+A G    
Sbjct: 1876 TVEIVDPGDESTVYIPEAEYKIEEDIGELLIPVRRSGDASQELIVICSTRQGSATGTISS 1935

Query: 585  ---GEDF----EDTCGELEFQNDEIVKIITIRIFDREEYEKECSFSLVLEEPKWIRRGMK 637
                 D+    ED    L F  +E  K   + I D   YE+E SFS+ L  P   + G +
Sbjct: 1936 TVLFSDYISRPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESFSVSLRLPVGGQLGAR 1995

Query: 638  GGFT----ITDEYDDKQPLTSKEEEERRIAEMGR 667
               T    + D YD  +P+    + E  + E  R
Sbjct: 1996 FPTTKVTILADRYD--EPVLHFGDAEYHVNESAR 2027



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 60/248 (24%), Positives = 98/248 (39%), Gaps = 34/248 (13%)

Query: 399  EVTENDPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAG---- 454
            E+ +    S ++  +  Y+  E+ G + + + RR GD +  + V   T  G+A       
Sbjct: 1878 EIVDPGDESTVYIPEAEYKIEEDIGELLIPV-RRSGDASQELIVICSTRQGSATGTISST 1936

Query: 455  ---SDY----EFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASED 507
               SDY    E     + F   +TQK  +V IIDD ++EE+E+F        VS      
Sbjct: 1937 VLFSDYISRPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESF-------SVSLRLPVG 1989

Query: 508  GILEANHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTS--- 564
            G L A           P+T    + D     +  F +   HV+ES   +EV V R     
Sbjct: 1990 GQLGARF---------PTTKVTILADRYDEPVLHFGDAEYHVNESARYVEVCVWRRGTDL 2040

Query: 565  GARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKIITIRIFD---REEYEKECS 621
                ++ V  +  E  +   G D+      L+F     ++   + I D   +   E    
Sbjct: 2041 SQPSSIAVRSRKSEQESAEAGTDYVGISRNLDFAPGVRMQTFQVTILDDLGQPTLEGPEK 2100

Query: 622  FSLVLEEP 629
            F L+L+ P
Sbjct: 2101 FELLLQMP 2108


>gi|79749430 FRAS1-related extracellular matrix protein 2 precursor
            [Homo sapiens]
          Length = 3169

 Score = 70.1 bits (170), Expect = 9e-12
 Identities = 66/236 (27%), Positives = 96/236 (40%), Gaps = 33/236 (13%)

Query: 429  IIRRGGDLTNTVFVDFRTEDGTANAGSDYEF-TEGTVVFKPGDTQKEIRVGIIDDDIFEE 487
            +++R G L  T F+   T D TA    D++   +  V F PG T+   RV I+ D   E+
Sbjct: 1790 VLKRRGYLGETSFISIGTRDRTAEKDKDFKGKAQKQVQFNPGQTRATWRVRILSDGEHEQ 1849

Query: 488  DENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVT 547
             E F V LS                     LA L  P+ ATV I D          +   
Sbjct: 1850 SETFQVVLSE------------------PVLAALEFPTVATVEIVDPGDEPTVFIPQSKY 1891

Query: 548  HVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARG-------GGEDF----EDTCGELE 596
             V E +G + + + R+      ++V   T +GTA G          D+    ED    + 
Sbjct: 1892 SVEEDVGELFIPIRRSGDVSQELMVVCYTQQGTATGTVPTSVLSYSDYISRPEDHTSVVR 1951

Query: 597  FQNDEIVKIITIRIFDREEYEKECSFSLVLEEPKWIRRGMK---GGFTITDEYDDK 649
            F  DE  K+  I I D   YE+E +F ++L  P   R G +      TI  + DD+
Sbjct: 1952 FDKDEREKLCRIVIIDDSLYEEEETFHVLLSMPMGGRIGSEFPGAQVTIVPDKDDE 2007



 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 73/278 (26%), Positives = 107/278 (38%), Gaps = 37/278 (13%)

Query: 399  EVTENDPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAG---- 454
            E+ +      +F  Q  Y   E+ G + + I RR GD++  + V   T+ GTA       
Sbjct: 1874 EIVDPGDEPTVFIPQSKYSVEEDVGELFIPI-RRSGDVSQELMVVCYTQQGTATGTVPTS 1932

Query: 455  ----SDY----EFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASE 506
                SDY    E     V F   + +K  R+ IIDD ++EE+E F V LS        SE
Sbjct: 1933 VLSYSDYISRPEDHTSVVRFDKDEREKLCRIVIIDDSLYEEEETFHVLLSMPMGGRIGSE 1992

Query: 507  DGILEANHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTS-- 564
                             P      + D D   IF F +    V ES G +EV+V RT   
Sbjct: 1993 ----------------FPGAQVTIVPDKDDEPIFYFGDVEYSVDESAGYVEVQVWRTGTD 2036

Query: 565  -GARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQ---NDEIVKIITIRIFDREEYEKEC 620
                 +V V  +  +  +   G D+      L+F    N + V+++ +    +   E   
Sbjct: 2037 LSKSSSVTVRSRKTDPPSADAGTDYVGISRNLDFAPGVNMQPVRVVILDDLGQPALEGIE 2096

Query: 621  SFSLVLEEPKWIRRG--MKGGFTITDEYDDKQPLTSKE 656
             F LVL  P     G   K   +I D   D   +  KE
Sbjct: 2097 KFELVLRMPMNAALGEPSKATVSINDSVSDLPKMQFKE 2134



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 59/218 (27%), Positives = 99/218 (45%), Gaps = 17/218 (7%)

Query: 400  VTENDPVS---KIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSD 456
            V+ ND VS   K+ F++  Y   E+ G + +T+I R GD+     V   T  G+A    D
Sbjct: 2118 VSINDSVSDLPKMQFKERIYTGSESDGQI-VTMIHRTGDVQYRSSVRCYTRQGSAQVMMD 2176

Query: 457  YEFTEGT----VVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEA 512
            +E    T    + F PG+T+K   + ++DD ++EE E   + L   + +S     G    
Sbjct: 2177 FEERPNTDTSIITFLPGETEKPCILELMDDVLYEEVEELRLVLGTPQSNSPF---GAAVG 2233

Query: 513  NHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIV 572
                TL  +   +  TV  F +    +   +EP     ES+ ++ + V+R        IV
Sbjct: 2234 EQNETLIRIRDDADKTVIKFGETKFSVTEPKEP----GESV-VIRIPVIRQGDTSKVSIV 2288

Query: 573  PYKTIEGTARGGGEDFEDTCGELEFQNDEIVKIITIRI 610
               T +G+A   GED+     E+EF+  E   ++ I +
Sbjct: 2289 RVHTKDGSAT-SGEDYHPVSEEIEFKEGETQHVVEIEV 2325



 Score = 54.3 bits (129), Expect = 5e-07
 Identities = 66/244 (27%), Positives = 101/244 (41%), Gaps = 30/244 (12%)

Query: 398  TEVTENDPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFR---TEDGTANAG 454
            T V + D     +F    Y   E+ G V + + R G DL+ +  V  R   T+  +A+AG
Sbjct: 1999 TIVPDKDDEPIFYFGDVEYSVDESAGYVEVQVWRTGTDLSKSSSVTVRSRKTDPPSADAG 2058

Query: 455  SDYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANH 514
            +DY      + F PG   + +RV I+DD                    + + +GI +   
Sbjct: 2059 TDYVGISRNLDFAPGVNMQPVRVVILDD------------------LGQPALEGIEKFEL 2100

Query: 515  VSTL---ACLGSPSTATVTIFDD-DHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNV 570
            V  +   A LG PS ATV+I D         F+E +   SES G +   + RT   +   
Sbjct: 2101 VLRMPMNAALGEPSKATVSINDSVSDLPKMQFKERIYTGSESDGQIVTMIHRTGDVQYRS 2160

Query: 571  IVPYKTIEGTARGGGEDFED----TCGELEFQNDEIVKIITIRIFDREEYEKECSFSLVL 626
             V   T +G+A+    DFE+        + F   E  K   + + D   YE+     LVL
Sbjct: 2161 SVRCYTRQGSAQ-VMMDFEERPNTDTSIITFLPGETEKPCILELMDDVLYEEVEELRLVL 2219

Query: 627  EEPK 630
              P+
Sbjct: 2220 GTPQ 2223



 Score = 47.8 bits (112), Expect = 5e-05
 Identities = 31/115 (26%), Positives = 56/115 (48%), Gaps = 6/115 (5%)

Query: 425  VALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDI 484
            + + +IR+G D +    V   T+DG+A +G DY      + FK G+TQ  + + +  D +
Sbjct: 2272 IRIPVIRQG-DTSKVSIVRVHTKDGSATSGEDYHPVSEEIEFKEGETQHVVEIEVTFDGV 2330

Query: 485  FEEDENFLVHL--SNVKVSSEASEDGILEANHVSTLACLGSPST---ATVTIFDD 534
             E  E F VHL      ++       I+    +S++A +  PS     ++ ++DD
Sbjct: 2331 REMREAFTVHLKPDENMIAEMQLTKAIVYIEEMSSMADVTFPSVPQIVSLLMYDD 2385


>gi|108773804 Fraser syndrome 1 [Homo sapiens]
          Length = 4011

 Score = 69.3 bits (168), Expect = 2e-11
 Identities = 65/242 (26%), Positives = 98/242 (40%), Gaps = 39/242 (16%)

Query: 407  SKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGS---------DY 457
            S I F+  +Y   E  G+V++T+ +R G+L     V  RTE GTA++ S         DY
Sbjct: 2552 SLISFKYTSYNVSEKAGSVSVTV-QRTGNLNQYAIVLCRTEQGTASSSSRVSSQPGQQDY 2610

Query: 458  EFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVST 517
                G V F   +  K   + I DDD+FE  E+F V LS                  +  
Sbjct: 2611 VEYAGQVQFDEREDTKSCTIVINDDDVFENVESFTVELS------------------MPA 2652

Query: 518  LACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTI 577
             A LG  + A V I D +      F++ +  V+ES G +   + R   A   V     T+
Sbjct: 2653 YALLGEFTQAKVIINDTEDEPTLEFDKKIYWVNESAGFLFAPIERKGDASSIVSAICYTV 2712

Query: 578  EGTARG-------GGEDFE----DTCGELEFQNDEIVKIITIRIFDREEYEKECSFSLVL 626
              +A G        G DF+         + F     +    + + D  EYE+E  F + L
Sbjct: 2713 PKSAMGSSLYALESGSDFKSRGMSAASRVIFGPGVTMSTCDVMLIDDSEYEEEEEFEIAL 2772

Query: 627  EE 628
             +
Sbjct: 2773 AD 2774



 Score = 67.4 bits (163), Expect = 6e-11
 Identities = 63/206 (30%), Positives = 89/206 (43%), Gaps = 23/206 (11%)

Query: 430  IRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGT----VVFKPGDTQKEIRVGIIDDDIF 485
            I R GDL+    V   T+  +A    D+E  +      + F  GD  K   V I DD +F
Sbjct: 2940 ITRSGDLSYESSVRCYTQSHSAQVMEDFEERQNADSSRITFLKGDKVKNCTVYIHDDSMF 2999

Query: 486  EEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHAGIFTFEEP 545
            E +E F V+L            G+   NH S  A +G  + AT+TI +D+ A    FEE 
Sbjct: 3000 EPEEQFRVYL------------GLPLGNHWSG-ARIGKNNMATITISNDEDAPTIEFEEA 3046

Query: 546  VTHVSE-----SIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQND 600
               V E     +I I+ +KV+R         V   T +G+A+  G D+      L+F   
Sbjct: 3047 AYQVREPAGPDAIAILNIKVIRRGDQNRTSKVRCSTRDGSAQ-SGVDYYPKSRVLKFSPG 3105

Query: 601  EIVKIITIRIFDREEYEKECSFSLVL 626
                   + I   E+ E   SFSLVL
Sbjct: 3106 VDHIFFKVEILSNEDREWHESFSLVL 3131



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 45/150 (30%), Positives = 64/150 (42%), Gaps = 20/150 (13%)

Query: 400  VTENDPVSKIFFEQGTYQCLENCGTVALTIIR----RGGDLTNTVFVDFRTEDGTANAGS 455
            ++ ++    I FE+  YQ  E  G  A+ I+     R GD   T  V   T DG+A +G 
Sbjct: 3032 ISNDEDAPTIEFEEAAYQVREPAGPDAIAILNIKVIRRGDQNRTSKVRCSTRDGSAQSGV 3091

Query: 456  DYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHV 515
            DY      + F PG      +V I+ ++  E  E+F + L           D  +E    
Sbjct: 3092 DYYPKSRVLKFSPGVDHIFFKVEILSNEDREWHESFSLVL---------GPDDPVE---- 3138

Query: 516  STLACLGSPSTATVTIFDDDHAGIFTFEEP 545
               A LG  +TATVTI D + AG      P
Sbjct: 3139 ---AVLGDVTTATVTILDQEAAGSLILPAP 3165



 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 56/231 (24%), Positives = 96/231 (41%), Gaps = 35/231 (15%)

Query: 401  TENDPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFT 460
            TE++P  +  F++  Y   E+ G +   I R+G D ++ V     T   +A   S Y   
Sbjct: 2669 TEDEPTLE--FDKKIYWVNESAGFLFAPIERKG-DASSIVSAICYTVPKSAMGSSLYALE 2725

Query: 461  EGT------------VVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDG 508
             G+            V+F PG T     V +IDD  +EE+E F + L+      +AS++ 
Sbjct: 2726 SGSDFKSRGMSAASRVIFGPGVTMSTCDVMLIDDSEYEEEEEFEIALA------DASDN- 2778

Query: 509  ILEANHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTS---G 565
                      A +G  +TA V I   + A   +       VSE  G +++ V+R      
Sbjct: 2779 ----------ARIGRVATAKVLISGPNDASTVSLGNTAFTVSEDAGTVKIPVIRHGTDLS 2828

Query: 566  ARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKIITIRIFDREEY 616
               +V    +  +  +   G D+  +  ++EF    I +  T+ I D  +Y
Sbjct: 2829 TFASVWCATRPSDPASATPGVDYVPSSRKVEFGPGVIEQYCTLTILDDTQY 2879



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 57/256 (22%), Positives = 105/256 (41%), Gaps = 31/256 (12%)

Query: 395  EVNTEVTENDPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVD--FRTEDGTAN 452
            E+ T   +   V  +  + GT + + N G   L  +   G  TN +        +  T +
Sbjct: 2418 EIMTAAPQPFRVDILPVDDGTPRIVTNLGLQWLEYM--DGKATNLITKKELLTMDPDTED 2475

Query: 453  AGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDEN-----FLVHLSNVKVSSEASED 507
            A   YE T G    K G  + +++ G       +ED N     +++H   ++   ++ + 
Sbjct: 2476 AQLVYEITTGP---KHGFVENKLQPGRAAATFTQEDVNLGLIRYVLHKEKIREMMDSFQF 2532

Query: 508  GILEANHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGAR 567
             + ++           P+  +  +F    + + +F+    +VSE  G + V V RT    
Sbjct: 2533 LVKDSK----------PNVVSDNVFHIQWS-LISFKYTSYNVSEKAGSVSVTVQRTGNLN 2581

Query: 568  GNVIVPYKTIEGTARG--------GGEDFEDTCGELEFQNDEIVKIITIRIFDREEYEKE 619
               IV  +T +GTA          G +D+ +  G+++F   E  K  TI I D + +E  
Sbjct: 2582 QYAIVLCRTEQGTASSSSRVSSQPGQQDYVEYAGQVQFDEREDTKSCTIVINDDDVFENV 2641

Query: 620  CSFSLVLEEPKWIRRG 635
             SF++ L  P +   G
Sbjct: 2642 ESFTVELSMPAYALLG 2657


>gi|31563526 solute carrier family 24 (sodium/potassium/calcium
           exchanger), member 3 [Homo sapiens]
          Length = 644

 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 51/177 (28%), Positives = 83/177 (46%), Gaps = 14/177 (7%)

Query: 722 EDDDDDECGEEKLPSCFDYVMHFL-TVFWK-------VLFAFVPPTEY--WNGW--ACFI 769
           E++++DE  +E   + FD     L TV W        VL+  VP      W  W    F 
Sbjct: 422 EEEEEDEDDDEGPYTPFDTPSGKLETVKWAFTWPLSFVLYFTVPNCNKPRWEKWFMVTFA 481

Query: 770 VSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADA 829
            S L I   +  +  + +  G T+G+ D +  + F+A GTSVPD  AS + A Q    D 
Sbjct: 482 SSTLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGM-GDM 540

Query: 830 SIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTLFTIFAFINV 886
           ++ N  GSN  ++ +G+G+ W++  +     G   +++   L +SV L     F+ V
Sbjct: 541 AVSNSIGSNVFDILIGLGLPWALQTL-AVDYGSYIRLNSRGLIYSVGLLLASVFVTV 596



 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 65/243 (26%), Positives = 100/243 (41%), Gaps = 48/243 (19%)

Query: 80  VYFVAMVYMFLGVSIIADRF-MSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLT 138
           ++ +  +YMF  ++I+ D F + S+E I  +                     +E V+  T
Sbjct: 112 LHVLCAIYMFYALAIVCDDFFVPSLEKICERLH------------------LSEDVAGAT 153

Query: 139 LMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKI 198
            MA GSSAPE+  SVI V     T GD+G  TIVGSA FN+  II +C            
Sbjct: 154 FMAAGSSAPELFTSVIGVF---ITKGDVGVGTIVGSAVFNILCIIGVCGLFAGQ------ 204

Query: 199 KHLRVFFVTAAWSIFAYTWLYIILSVISPGV------VEVWEGLLTFFFFPICVVFAWVA 252
                    ++W +   + +Y  LSVI+  V      V  WE L+    + I +V     
Sbjct: 205 -----VVALSSWCLLRDS-IYYTLSVIALIVFIYDEKVSWWESLVLVLMYLIYIVI---- 254

Query: 253 DRRLLFYKYVYKRY-RAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHVENFLDGALVLE 311
              + +   +++ + R  K  G ++    +          D  VV     NF   A V+ 
Sbjct: 255 ---MKYNACIHQCFERRTKGAGNMVNGLANNAEIDDSSNCDATVVLLKKANFHRKASVIM 311

Query: 312 VDE 314
           VDE
Sbjct: 312 VDE 314



 Score = 35.4 bits (80), Expect = 0.25
 Identities = 33/139 (23%), Positives = 54/139 (38%), Gaps = 21/139 (15%)

Query: 795 LKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAA 854
           L + V    F+A G+S P+ F S +     +  D  +G + GS   N+   IGV    A 
Sbjct: 145 LSEDVAGATFMAAGSSAPELFTSVIGVFITK-GDVGVGTIVGSAVFNILCIIGVCGLFA- 202

Query: 855 IYHAANGEQFKVSPGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCL 914
                 G+   +S   L      +T+ + I + V +Y  +                 S +
Sbjct: 203 ------GQVVALSSWCLLRDSIYYTL-SVIALIVFIYDEK------------VSWWESLV 243

Query: 915 FVLLWLLYIFFSSLEAYCH 933
            VL++L+YI      A  H
Sbjct: 244 LVLMYLIYIVIMKYNACIH 262


>gi|29788987 solute carrier family 24 member 4 isoform 3 [Homo
           sapiens]
          Length = 558

 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 36/110 (32%), Positives = 58/110 (52%), Gaps = 2/110 (1%)

Query: 768 FIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYA 827
           FI + L I + +  +  L +  G T+G+ D +  + F+A GTSVPD  AS + A Q    
Sbjct: 393 FITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQG-LG 451

Query: 828 DASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTL 877
           D ++ N  GSN  ++ +G+GV W +  +     G   K++   L +SV L
Sbjct: 452 DMAVSNTIGSNVFDILVGLGVPWGLQTMV-VNYGSTVKINSRGLVYSVVL 500



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 45/164 (27%), Positives = 75/164 (45%), Gaps = 28/164 (17%)

Query: 80  VYFVAMVYMFLGVSIIADRF-MSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLT 138
           ++ +  +YMF  ++I+ D F + S+E I  +                     +E V+  T
Sbjct: 38  LHILGALYMFYALAIVCDDFFVPSLEKICERLH------------------LSEDVAGAT 79

Query: 139 LMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKI 198
            MA GSS PE+  SVI V     T GD+G  TIVGSA FN+  II +C      G+  ++
Sbjct: 80  FMAAGSSTPELFASVIGVF---ITHGDVGVGTIVGSAVFNILCIIGVCGLFA--GQVVRL 134

Query: 199 KHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFFFF 242
                ++     S++    + +++  I    +  WEGL+    +
Sbjct: 135 ----TWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILY 174



 Score = 36.6 bits (83), Expect = 0.11
 Identities = 23/90 (25%), Positives = 40/90 (44%), Gaps = 3/90 (3%)

Query: 795 LKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAA 854
           L + V    F+A G+S P+ FAS V      + D  +G + GS   N+   IGV    A 
Sbjct: 71  LSEDVAGATFMAAGSSTPELFAS-VIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAG 129

Query: 855 IYHAANGEQFKVSPGTLAFSVTLFTIFAFI 884
                    + V   ++ +++++  +  FI
Sbjct: 130 --QVVRLTWWAVCRDSVYYTISVIVLIVFI 157


>gi|29788985 solute carrier family 24 member 4 isoform 2 precursor
           [Homo sapiens]
          Length = 586

 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 36/110 (32%), Positives = 58/110 (52%), Gaps = 2/110 (1%)

Query: 768 FIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYA 827
           FI + L I + +  +  L +  G T+G+ D +  + F+A GTSVPD  AS + A Q    
Sbjct: 421 FITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQG-LG 479

Query: 828 DASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTL 877
           D ++ N  GSN  ++ +G+GV W +  +     G   K++   L +SV L
Sbjct: 480 DMAVSNTIGSNVFDILVGLGVPWGLQTMV-VNYGSTVKINSRGLVYSVVL 528



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 54/226 (23%), Positives = 96/226 (42%), Gaps = 29/226 (12%)

Query: 80  VYFVAMVYMFLGVSIIADRF-MSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLT 138
           ++ +  +YMF  ++I+ D F + S+E I  +                     +E V+  T
Sbjct: 85  LHILGALYMFYALAIVCDDFFVPSLEKICERLH------------------LSEDVAGAT 126

Query: 139 LMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKI 198
            MA GSS PE+  SVI V     T GD+G  TIVGSA FN+  II +C      G+  ++
Sbjct: 127 FMAAGSSTPELFASVIGVF---ITHGDVGVGTIVGSAVFNILCIIGVCGLFA--GQVVRL 181

Query: 199 KHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFFFFPICVVFAWVADRRLLF 258
                ++     S++    + +++  I    +  WEGL+    +   ++      +   F
Sbjct: 182 ----TWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIMKYNVKMQAF 237

Query: 259 YKYVYKRYRAGKQRGMIIEHEGDRPS-SKTEIEMDGKVVNSHVENF 303
           +    K    G      +E   ++P   K  + M  ++++S    F
Sbjct: 238 FTVKQKSIANGNPVNSELEAVKEKPQYGKNPVVMVDEIMSSSPPKF 283



 Score = 36.6 bits (83), Expect = 0.11
 Identities = 23/90 (25%), Positives = 40/90 (44%), Gaps = 3/90 (3%)

Query: 795 LKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAA 854
           L + V    F+A G+S P+ FAS V      + D  +G + GS   N+   IGV    A 
Sbjct: 118 LSEDVAGATFMAAGSSTPELFAS-VIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAG 176

Query: 855 IYHAANGEQFKVSPGTLAFSVTLFTIFAFI 884
                    + V   ++ +++++  +  FI
Sbjct: 177 --QVVRLTWWAVCRDSVYYTISVIVLIVFI 204


>gi|24111228 solute carrier family 24 member 4 isoform 1 precursor
           [Homo sapiens]
          Length = 605

 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 36/110 (32%), Positives = 58/110 (52%), Gaps = 2/110 (1%)

Query: 768 FIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYA 827
           FI + L I + +  +  L +  G T+G+ D +  + F+A GTSVPD  AS + A Q    
Sbjct: 440 FITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQG-LG 498

Query: 828 DASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTL 877
           D ++ N  GSN  ++ +G+GV W +  +     G   K++   L +SV L
Sbjct: 499 DMAVSNTIGSNVFDILVGLGVPWGLQTMV-VNYGSTVKINSRGLVYSVVL 547



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 45/164 (27%), Positives = 75/164 (45%), Gaps = 28/164 (17%)

Query: 80  VYFVAMVYMFLGVSIIADRF-MSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLT 138
           ++ +  +YMF  ++I+ D F + S+E I  +                     +E V+  T
Sbjct: 85  LHILGALYMFYALAIVCDDFFVPSLEKICERLH------------------LSEDVAGAT 126

Query: 139 LMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKI 198
            MA GSS PE+  SVI V     T GD+G  TIVGSA FN+  II +C      G+  ++
Sbjct: 127 FMAAGSSTPELFASVIGVF---ITHGDVGVGTIVGSAVFNILCIIGVCGLFA--GQVVRL 181

Query: 199 KHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFFFF 242
                ++     S++    + +++  I    +  WEGL+    +
Sbjct: 182 ----TWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILY 221



 Score = 36.6 bits (83), Expect = 0.11
 Identities = 23/90 (25%), Positives = 40/90 (44%), Gaps = 3/90 (3%)

Query: 795 LKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAA 854
           L + V    F+A G+S P+ FAS V      + D  +G + GS   N+   IGV    A 
Sbjct: 118 LSEDVAGATFMAAGSSTPELFAS-VIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAG 176

Query: 855 IYHAANGEQFKVSPGTLAFSVTLFTIFAFI 884
                    + V   ++ +++++  +  FI
Sbjct: 177 --QVVRLTWWAVCRDSVYYTISVIVLIVFI 204


>gi|45504369 solute carrier family 24, member 5 [Homo sapiens]
          Length = 500

 Score = 63.5 bits (153), Expect = 9e-10
 Identities = 50/169 (29%), Positives = 82/169 (48%), Gaps = 28/169 (16%)

Query: 80  VYFVAMVYMFLGVSIIADR-FMSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLT 138
           +YF+ +VYMF+ +SI+ D  F+ S+E+I+                       ++ V+  T
Sbjct: 71  IYFLIIVYMFMAISIVCDEYFLPSLEIISESLG------------------LSQDVAGTT 112

Query: 139 LMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKI 198
            MA GSSAPE++ + + V     T GD+G STI+GSA +N+  I A C  +        +
Sbjct: 113 FMAAGSSAPELVTAFLGVF---ITKGDIGISTILGSAIYNLLGICAACGLL--SNTVSTL 167

Query: 199 KHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFFFFPICVV 247
               +F   AA++I A      +L +I    V  +EG L    + + V+
Sbjct: 168 SCWPLFRDCAAYTISAAA----VLGIIYDNQVYWYEGALLLLIYGLYVL 212



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 42/153 (27%), Positives = 73/153 (47%), Gaps = 15/153 (9%)

Query: 747 VFW-------KVLFAFVPPT--EYWNGW--ACFIVSILMIGLLTAFIGDLASHFGCTIGL 795
           +FW        +LF   P    ++W  +    F +S + I   T  +  + +  G T+ +
Sbjct: 306 IFWVLSLPIITLLFLTTPDCRKKFWKNYFVITFFMSAIWISAFTYILVWMVTITGETLEI 365

Query: 796 KDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSI--A 853
            D+V  +  +A GTS+PDT AS + A + +  D ++ N+ GSN  ++ L +G+ W I  A
Sbjct: 366 PDTVMGLTLLAAGTSIPDTIASVLVARKGK-GDMAMSNIVGSNVFDM-LCLGIPWFIKTA 423

Query: 854 AIYHAANGEQFKVSPGTLAFSVTLFTIFAFINV 886
            I  +A  E        +  S+ +  IF F+ V
Sbjct: 424 FINGSAPAEVNSRGLTYITISLNISIIFLFLAV 456



 Score = 35.8 bits (81), Expect = 0.19
 Identities = 27/84 (32%), Positives = 41/84 (48%), Gaps = 8/84 (9%)

Query: 99  FMSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCG 158
           FMS+I +       + +    GET +       +TV  LTL+A G+S P+ + SV+    
Sbjct: 339 FMSAIWISAFTYILVWMVTITGETLEIP-----DTVMGLTLLAAGTSIPDTIASVLVA-- 391

Query: 159 HNFTAGDLGPSTIVGSAAFNMFII 182
                GD+  S IVGS  F+M  +
Sbjct: 392 -RKGKGDMAMSNIVGSNVFDMLCL 414


>gi|9966787 solute carrier family 24 (sodium/potassium/calcium
           exchanger), member 2 [Homo sapiens]
          Length = 661

 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 50/175 (28%), Positives = 81/175 (46%), Gaps = 38/175 (21%)

Query: 80  VYFVAMVYMFLGVSIIADRF-MSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLT 138
           ++ + M+YMF+ ++I+ D F + S+ VIT   +++ I               ++ V+  T
Sbjct: 137 LHVIGMIYMFIALAIVCDEFFVPSLTVIT---EKLGI---------------SDDVAGAT 178

Query: 139 LMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKI 198
            MA G SAPE+  S+I V        ++G  TIVGSA FN+  +I +C        +R+I
Sbjct: 179 FMAAGGSAPELFTSLIGVF---IAHSNVGIGTIVGSAVFNILFVIGMCALF-----SREI 230

Query: 199 KHLRVFFVTAAWSIFAYTWLYII-----LSVISPGVVEVWEGLLTFFFFPICVVF 248
            +L        W +F     YI+     +      V+  WE LL    +   VVF
Sbjct: 231 LNL------TWWPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYFCYVVF 279



 Score = 50.4 bits (119), Expect = 8e-06
 Identities = 32/127 (25%), Positives = 58/127 (45%), Gaps = 2/127 (1%)

Query: 768 FIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYA 827
           F  SI  I + +  +   A   G TIG+ + +  +  +A GTS+PD   S + A +    
Sbjct: 503 FFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKG-LG 561

Query: 828 DASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTLFTIFAFINVG 887
           D ++ +  GSN  ++ +G+ + W +  + H         S G     V LF +  F+ + 
Sbjct: 562 DMAVSSSVGSNIFDITVGLPLPWLLYTVIHRFQPVAVS-SNGLFCAIVLLFIMLLFVILS 620

Query: 888 VLLYRRR 894
           + L + R
Sbjct: 621 IALCKWR 627



 Score = 35.4 bits (80), Expect = 0.25
 Identities = 17/56 (30%), Positives = 28/56 (50%), Gaps = 1/56 (1%)

Query: 793 IGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGV 848
           +G+ D V    F+A G S P+ F S +      +++  IG + GS   N+   IG+
Sbjct: 168 LGISDDVAGATFMAAGGSAPELFTSLIGVF-IAHSNVGIGTIVGSAVFNILFVIGM 222



 Score = 32.0 bits (71), Expect = 2.8
 Identities = 18/55 (32%), Positives = 32/55 (58%), Gaps = 3/55 (5%)

Query: 131 NETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIAL 185
           +E +  LT++A G+S P+++ SVI         GD+  S+ VGS  F++ + + L
Sbjct: 531 SEEIMGLTILAAGTSIPDLITSVIVA---RKGLGDMAVSSSVGSNIFDITVGLPL 582


>gi|54607027 integrin beta 4 isoform 2 precursor [Homo sapiens]
          Length = 1805

 Score = 50.8 bits (120), Expect = 6e-06
 Identities = 41/146 (28%), Positives = 63/146 (43%), Gaps = 24/146 (16%)

Query: 396  VNTEVTENDPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGS 455
            VN  + +      + FEQ  +          + +IRR  D   +  V +RT+DGTA    
Sbjct: 979  VNITIIKEQARDVVSFEQPEFSVSRGDQVARIPVIRRVLDGGKSQ-VSYRTQDGTAQGNR 1037

Query: 456  DYEFTEGTVVFKPGDTQKEIRVGIID----DDIF--EEDENFLVHLSNVKVSSEASEDGI 509
            DY   EG ++F+PG+  KE++V +++    D +    +   F V LSN K          
Sbjct: 1038 DYIPVEGELLFQPGEAWKELQVKLLELQEVDSLLRGRQVRRFHVQLSNPKFG-------- 1089

Query: 510  LEANHVSTLACLGSPSTATVTIFDDD 535
                     A LG P + T+ I D D
Sbjct: 1090 ---------AHLGQPHSTTIIIRDPD 1106



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 42/177 (23%), Positives = 74/177 (41%), Gaps = 19/177 (10%)

Query: 441  FVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKV 500
            F D +   G     +D +   G V F+ G    ++RV +      ++++  LV   +V  
Sbjct: 911  FHDLKVAPGYYTLTADQD-ARGMVEFQEGVELVDVRVPLFIRPEDDDEKQLLVEAIDVPA 969

Query: 501  SSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKV 560
             +                A LG      +TI  +    + +FE+P   VS    +  + V
Sbjct: 970  GT----------------ATLGR-RLVNITIIKEQARDVVSFEQPEFSVSRGDQVARIPV 1012

Query: 561  LRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKIITIRIFDREEYE 617
            +R     G   V Y+T +GTA+ G  D+    GEL FQ  E  K + +++ + +E +
Sbjct: 1013 IRRVLDGGKSQVSYRTQDGTAQ-GNRDYIPVEGELLFQPGEAWKELQVKLLELQEVD 1068


>gi|54607035 integrin beta 4 isoform 1 precursor [Homo sapiens]
          Length = 1822

 Score = 50.8 bits (120), Expect = 6e-06
 Identities = 41/146 (28%), Positives = 63/146 (43%), Gaps = 24/146 (16%)

Query: 396  VNTEVTENDPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGS 455
            VN  + +      + FEQ  +          + +IRR  D   +  V +RT+DGTA    
Sbjct: 979  VNITIIKEQARDVVSFEQPEFSVSRGDQVARIPVIRRVLDGGKSQ-VSYRTQDGTAQGNR 1037

Query: 456  DYEFTEGTVVFKPGDTQKEIRVGIID----DDIF--EEDENFLVHLSNVKVSSEASEDGI 509
            DY   EG ++F+PG+  KE++V +++    D +    +   F V LSN K          
Sbjct: 1038 DYIPVEGELLFQPGEAWKELQVKLLELQEVDSLLRGRQVRRFHVQLSNPKFG-------- 1089

Query: 510  LEANHVSTLACLGSPSTATVTIFDDD 535
                     A LG P + T+ I D D
Sbjct: 1090 ---------AHLGQPHSTTIIIRDPD 1106



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 42/177 (23%), Positives = 74/177 (41%), Gaps = 19/177 (10%)

Query: 441  FVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKV 500
            F D +   G     +D +   G V F+ G    ++RV +      ++++  LV   +V  
Sbjct: 911  FHDLKVAPGYYTLTADQD-ARGMVEFQEGVELVDVRVPLFIRPEDDDEKQLLVEAIDVPA 969

Query: 501  SSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKV 560
             +                A LG      +TI  +    + +FE+P   VS    +  + V
Sbjct: 970  GT----------------ATLGR-RLVNITIIKEQARDVVSFEQPEFSVSRGDQVARIPV 1012

Query: 561  LRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKIITIRIFDREEYE 617
            +R     G   V Y+T +GTA+ G  D+    GEL FQ  E  K + +++ + +E +
Sbjct: 1013 IRRVLDGGKSQVSYRTQDGTAQ-GNRDYIPVEGELLFQPGEAWKELQVKLLELQEVD 1068


>gi|54607033 integrin beta 4 isoform 3 precursor [Homo sapiens]
          Length = 1752

 Score = 50.8 bits (120), Expect = 6e-06
 Identities = 41/146 (28%), Positives = 63/146 (43%), Gaps = 24/146 (16%)

Query: 396  VNTEVTENDPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGS 455
            VN  + +      + FEQ  +          + +IRR  D   +  V +RT+DGTA    
Sbjct: 979  VNITIIKEQARDVVSFEQPEFSVSRGDQVARIPVIRRVLDGGKSQ-VSYRTQDGTAQGNR 1037

Query: 456  DYEFTEGTVVFKPGDTQKEIRVGIID----DDIF--EEDENFLVHLSNVKVSSEASEDGI 509
            DY   EG ++F+PG+  KE++V +++    D +    +   F V LSN K          
Sbjct: 1038 DYIPVEGELLFQPGEAWKELQVKLLELQEVDSLLRGRQVRRFHVQLSNPKFG-------- 1089

Query: 510  LEANHVSTLACLGSPSTATVTIFDDD 535
                     A LG P + T+ I D D
Sbjct: 1090 ---------AHLGQPHSTTIIIRDPD 1106



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 42/177 (23%), Positives = 74/177 (41%), Gaps = 19/177 (10%)

Query: 441  FVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKV 500
            F D +   G     +D +   G V F+ G    ++RV +      ++++  LV   +V  
Sbjct: 911  FHDLKVAPGYYTLTADQD-ARGMVEFQEGVELVDVRVPLFIRPEDDDEKQLLVEAIDVPA 969

Query: 501  SSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKV 560
             +                A LG      +TI  +    + +FE+P   VS    +  + V
Sbjct: 970  GT----------------ATLGR-RLVNITIIKEQARDVVSFEQPEFSVSRGDQVARIPV 1012

Query: 561  LRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKIITIRIFDREEYE 617
            +R     G   V Y+T +GTA+ G  D+    GEL FQ  E  K + +++ + +E +
Sbjct: 1013 IRRVLDGGKSQVSYRTQDGTAQ-GNRDYIPVEGELLFQPGEAWKELQVKLLELQEVD 1068


>gi|4759128 solute carrier family 24 (sodium/potassium/calcium
           exchanger), member 1 [Homo sapiens]
          Length = 1099

 Score = 50.8 bits (120), Expect = 6e-06
 Identities = 44/168 (26%), Positives = 78/168 (46%), Gaps = 28/168 (16%)

Query: 80  VYFVAMVYMFLGVSIIADR-FMSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLT 138
           ++   M+Y+F+ ++I+ D  F+ ++ VIT + +                   +E V+  T
Sbjct: 457 LHVFGMMYVFVALAIVCDEYFVPALGVITDKLQI------------------SEDVAGAT 498

Query: 139 LMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKI 198
            MA G SAPE+  S+I V     +  ++G  TIVGSA FN+  +I  C        +R+I
Sbjct: 499 FMAAGGSAPELFTSLIGVF---ISHSNVGIGTIVGSAVFNILFVIGTCSLF-----SREI 550

Query: 199 KHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFFFFPICV 246
            +L  + +    S +    + +IL  +   ++  WE LL    +   V
Sbjct: 551 LNLTWWPLFRDVSFYILDLIMLILFFLD-SLIAWWESLLLLLAYAFYV 597



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 30/117 (25%), Positives = 56/117 (47%), Gaps = 2/117 (1%)

Query: 768  FIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYA 827
            F+ SI+ I + +  +   A   G TIG+ + +  +  +A GTS+PD   S + A +    
Sbjct: 941  FLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKG-LG 999

Query: 828  DASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTLFTIFAFI 884
            D ++ +  GSN  ++ +G+ V W + ++ +         S G     V LF +  F+
Sbjct: 1000 DMAVSSSVGSNIFDITVGLPVPWLLFSLINGLQPVPVS-SNGLFCAIVLLFLMLLFV 1055



 Score = 31.6 bits (70), Expect = 3.6
 Identities = 17/51 (33%), Positives = 30/51 (58%), Gaps = 3/51 (5%)

Query: 131  NETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFI 181
            +E +  LT++A G+S P+++ SVI         GD+  S+ VGS  F++ +
Sbjct: 969  SEEIMGLTILAAGTSIPDLITSVIVA---RKGLGDMAVSSSVGSNIFDITV 1016



 Score = 30.8 bits (68), Expect = 6.2
 Identities = 15/53 (28%), Positives = 25/53 (47%), Gaps = 1/53 (1%)

Query: 795 LKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIG 847
           + + V    F+A G S P+ F S +      +++  IG + GS   N+   IG
Sbjct: 490 ISEDVAGATFMAAGGSAPELFTSLIGVF-ISHSNVGIGTIVGSAVFNILFVIG 541


>gi|122056683 FRAS1 related extracellular matrix 1 [Homo sapiens]
          Length = 2179

 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 30/92 (32%), Positives = 47/92 (51%), Gaps = 2/92 (2%)

Query: 407  SKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVV- 465
            S I + Q  Y+  EN G + L IIRRG  + ++ FV  +    +A  G D+      ++ 
Sbjct: 1741 SHIEWSQTEYEVCENVGLLPLEIIRRGYSM-DSAFVGIKVNQVSAAVGKDFTVIPSKLIQ 1799

Query: 466  FKPGDTQKEIRVGIIDDDIFEEDENFLVHLSN 497
            F PG + K   + I  D + E+DE F V L++
Sbjct: 1800 FDPGMSTKMWNIAITYDGLEEDDEVFEVILNS 1831


>gi|39995086 solute carrier family 24 member 6 [Homo sapiens]
          Length = 584

 Score = 36.6 bits (83), Expect = 0.11
 Identities = 37/157 (23%), Positives = 68/157 (43%), Gaps = 17/157 (10%)

Query: 752 LFAFVPPT------EYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFV 805
           +F   PP+        +  W  ++  IL +     F  +L++    T+ L  +V  V F+
Sbjct: 87  IFCHFPPSLLPLAVTLYVSWLLYLFLILGVTAAKFFCPNLSA-ISTTLKLSHNVAGVTFL 145

Query: 806 ALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFK 865
           A G   PD F++ VA +    A  ++G + G+  V V   +    +I   + AA+   F+
Sbjct: 146 AFGNGAPDIFSALVAFSDPHTAGLALGALFGA-GVLVTTVVAGGITILHPFMAASRPFFR 204

Query: 866 VSPGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGELG 902
                + + V +F  F      ++L+R R  +   LG
Sbjct: 205 ---DIVFYMVAVFLTF------LMLFRGRVTLAWALG 232


>gi|209862785 anoctamin 2 [Homo sapiens]
          Length = 998

 Score = 36.2 bits (82), Expect = 0.15
 Identities = 29/105 (27%), Positives = 49/105 (46%), Gaps = 27/105 (25%)

Query: 652 LTSKEEEERRIAEMGRPILGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTNSWREQ 711
           LT  EEEE R  E  RP               YE K   +K++K++N + V        Q
Sbjct: 467 LTGIEEEEERAQEHSRP--------------EYETK-VREKMLKESNQSAV--------Q 503

Query: 712 FIEAITVSAGEDDDDDE-CGEEKLPSCFDYVMHFLTVFWKVLFAF 755
            +E  T   G++DD+D+   +++ P    Y+M+F ++ + +   F
Sbjct: 504 KLETNTTECGDEDDEDKLTWKDRFPG---YLMNFASILFMIALTF 545


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.137    0.407 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,029,005
Number of Sequences: 37866
Number of extensions: 1505426
Number of successful extensions: 4573
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 28
Number of HSP's successfully gapped in prelim test: 23
Number of HSP's that attempted gapping in prelim test: 4349
Number of HSP's gapped (non-prelim): 136
length of query: 937
length of database: 18,247,518
effective HSP length: 112
effective length of query: 825
effective length of database: 14,006,526
effective search space: 11555383950
effective search space used: 11555383950
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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