Search of human proteins with 161333837

Search of human proteins with 161333837

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|161333837 activin A receptor, type IC isoform 3 [Homo
sapiens]
         (413 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|161333837 activin A receptor, type IC isoform 3 [Homo sapiens]     847   0.0  
gi|161333835 activin A receptor, type IC isoform 2 [Homo sapiens]     639   0.0  
gi|161333833 activin A receptor, type IC isoform 1 [Homo sapiens]     639   0.0  
gi|195963412 transforming growth factor, beta receptor I isoform...   589   e-168
gi|4759226 transforming growth factor, beta receptor I isoform 1...   537   e-153
gi|4757720 activin A receptor, type IB isoform a precursor [Homo...   533   e-151
gi|161333839 activin A receptor, type IC isoform 4 [Homo sapiens]     482   e-136
gi|33598910 activin A receptor, type IB isoform b precursor [Hom...   465   e-131
gi|4502431 bone morphogenetic protein receptor, type IB precurso...   422   e-118
gi|166235898 activin A receptor, type I precursor [Homo sapiens]      412   e-115
gi|4501895 activin A receptor, type I precursor [Homo sapiens]        412   e-115
gi|41349437 bone morphogenetic protein receptor, type IA precurs...   412   e-115
gi|33598912 activin A receptor, type IB isoform c precursor [Hom...   388   e-108
gi|116734714 activin A receptor type II-like 1 [Homo sapiens]         385   e-107
gi|116734712 activin A receptor type II-like 1 [Homo sapiens]         385   e-107
gi|4501897 activin A receptor, type IIA precursor [Homo sapiens]      229   3e-60
gi|67782324 transforming growth factor, beta receptor II isoform...   223   3e-58
gi|67782326 transforming growth factor, beta receptor II isoform...   223   3e-58
gi|116734708 activin A receptor, type IIB precursor [Homo sapiens]    223   3e-58
gi|15451916 bone morphogenetic protein receptor type II precurso...   187   2e-47
gi|10198656 anti-Mullerian hormone receptor, type II [Homo sapiens]   159   3e-39
gi|187475373 c-src tyrosine kinase [Homo sapiens]                      89   7e-18
gi|4758078 c-src tyrosine kinase [Homo sapiens]                        89   7e-18
gi|19526767 MLK-related kinase isoform 2 [Homo sapiens]                82   9e-16
gi|82880648 MLK-related kinase isoform 1 [Homo sapiens]                82   9e-16
gi|4506401 v-raf-1 murine leukemia viral oncogene homolog 1 [Hom...    81   2e-15
gi|21735566 mitogen-activated protein kinase kinase kinase 7 iso...    80   3e-15
gi|21735564 mitogen-activated protein kinase kinase kinase 7 iso...    80   3e-15
gi|21735562 mitogen-activated protein kinase kinase kinase 7 iso...    80   3e-15
gi|4507361 mitogen-activated protein kinase kinase kinase 7 isof...    80   3e-15

>gi|161333837 activin A receptor, type IC isoform 3 [Homo sapiens]
          Length = 413

 Score =  847 bits (2187), Expect = 0.0
 Identities = 413/413 (100%), Positives = 413/413 (100%)

Query: 1   MTRALCSALRQALLLLAAAAELSPGLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVI 60
           MTRALCSALRQALLLLAAAAELSPGLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVI
Sbjct: 1   MTRALCSALRQALLLLAAAAELSPGLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVI 60

Query: 61  KSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPTGLPLLVQRTIARTIVLQEI 120
           KSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPTGLPLLVQRTIARTIVLQEI
Sbjct: 61  KSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPTGLPLLVQRTIARTIVLQEI 120

Query: 121 VGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADNKDN 180
           VGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADNKDN
Sbjct: 121 VGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADNKDN 180

Query: 181 GTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQGKPAIA 240
           GTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQGKPAIA
Sbjct: 181 GTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQGKPAIA 240

Query: 241 HRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDDTMNV 300
           HRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDDTMNV
Sbjct: 241 HRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDDTMNV 300

Query: 301 NIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQKF 360
           NIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQKF
Sbjct: 301 NIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQKF 360

Query: 361 RPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQLCVKEDCKA 413
           RPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQLCVKEDCKA
Sbjct: 361 RPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQLCVKEDCKA 413


>gi|161333835 activin A receptor, type IC isoform 2 [Homo sapiens]
          Length = 443

 Score =  639 bits (1647), Expect = 0.0
 Identities = 312/313 (99%), Positives = 313/313 (100%)

Query: 101 TGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQ 160
           +GLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQ
Sbjct: 131 SGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQ 190

Query: 161 TVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIA 220
           TVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIA
Sbjct: 191 TVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIA 250

Query: 221 SGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQN 280
           SGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQN
Sbjct: 251 SGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQN 310

Query: 281 PKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYD 340
           PKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYD
Sbjct: 311 PKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYD 370

Query: 341 MVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKK 400
           MVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKK
Sbjct: 371 MVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKK 430

Query: 401 TISQLCVKEDCKA 413
           TISQLCVKEDCKA
Sbjct: 431 TISQLCVKEDCKA 443



 Score =  114 bits (285), Expect = 2e-25
 Identities = 52/54 (96%), Positives = 52/54 (96%)

Query: 51  MLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPTGLP 104
           MLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPT  P
Sbjct: 1   MLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPTASP 54


>gi|161333833 activin A receptor, type IC isoform 1 [Homo sapiens]
          Length = 493

 Score =  639 bits (1647), Expect = 0.0
 Identities = 312/313 (99%), Positives = 313/313 (100%)

Query: 101 TGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQ 160
           +GLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQ
Sbjct: 181 SGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQ 240

Query: 161 TVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIA 220
           TVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIA
Sbjct: 241 TVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIA 300

Query: 221 SGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQN 280
           SGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQN
Sbjct: 301 SGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQN 360

Query: 281 PKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYD 340
           PKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYD
Sbjct: 361 PKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYD 420

Query: 341 MVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKK 400
           MVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKK
Sbjct: 421 MVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKK 480

Query: 401 TISQLCVKEDCKA 413
           TISQLCVKEDCKA
Sbjct: 481 TISQLCVKEDCKA 493



 Score =  214 bits (546), Expect = 9e-56
 Identities = 102/104 (98%), Positives = 102/104 (98%)

Query: 1   MTRALCSALRQALLLLAAAAELSPGLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVI 60
           MTRALCSALRQALLLLAAAAELSPGLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVI
Sbjct: 1   MTRALCSALRQALLLLAAAAELSPGLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVI 60

Query: 61  KSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPTGLP 104
           KSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPT  P
Sbjct: 61  KSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPTASP 104


>gi|195963412 transforming growth factor, beta receptor I isoform 2
           precursor [Homo sapiens]
          Length = 426

 Score =  589 bits (1519), Expect = e-168
 Identities = 305/424 (71%), Positives = 340/424 (80%), Gaps = 16/424 (3%)

Query: 4   ALCSALRQALLLL------AAAAELSPG---LKCVCLLCDSSNFTCQTEGACWASVMLTN 54
           A  +A R  LLLL      AAAA L PG   L+C C LC   NFTC T+G C+ SV  T 
Sbjct: 3   AAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETT 62

Query: 55  GKEQVIKSCVS----LPELNAQVFCHSSN--NVTKTECCFTDFCNNITLHLPTGLPLLVQ 108
            K      C++    +P     V   SS   +VT T CC  D CN I L   TGLPLLVQ
Sbjct: 63  DKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPT-TGLPLLVQ 121

Query: 109 RTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHEN 168
           RTIARTIVLQE +GKGRFGEVW G+W GE+VAVKIFSSR+ERSWFREAEIYQTVMLRHEN
Sbjct: 122 RTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHEN 181

Query: 169 ILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHM 228
           ILGFIAADNKDNGTWTQLWLVS+YHE GSL+DYLNR  VTV GMIKLALS ASGLAHLHM
Sbjct: 182 ILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHM 241

Query: 229 EIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRY 288
           EIVGTQGKPAIAHRD+KSKNILVKK  TC IADLGLAV+HDS  +TIDI  N +VGTKRY
Sbjct: 242 EIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRY 301

Query: 289 MAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSI 348
           MAPE+LDD++N+  FESFKRADIY++GLV+WEIARRCS+GGI E+YQLPYYD+VPSDPS+
Sbjct: 302 MAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSV 361

Query: 349 EEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQLCVK 408
           EEMRKVVC+QK RP+IPN+WQSCEALRVM +IMRECWYANGAARLTALRIKKT+SQL  +
Sbjct: 362 EEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQ 421

Query: 409 EDCK 412
           E  K
Sbjct: 422 EGIK 425


>gi|4759226 transforming growth factor, beta receptor I isoform 1
           precursor [Homo sapiens]
          Length = 503

 Score =  537 bits (1383), Expect = e-153
 Identities = 259/312 (83%), Positives = 287/312 (91%)

Query: 101 TGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQ 160
           +GLPLLVQRTIARTIVLQE +GKGRFGEVW G+W GE+VAVKIFSSR+ERSWFREAEIYQ
Sbjct: 191 SGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQ 250

Query: 161 TVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIA 220
           TVMLRHENILGFIAADNKDNGTWTQLWLVS+YHE GSL+DYLNR  VTV GMIKLALS A
Sbjct: 251 TVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTA 310

Query: 221 SGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQN 280
           SGLAHLHMEIVGTQGKPAIAHRD+KSKNILVKK  TC IADLGLAV+HDS  +TIDI  N
Sbjct: 311 SGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPN 370

Query: 281 PKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYD 340
            +VGTKRYMAPE+LDD++N+  FESFKRADIY++GLV+WEIARRCS+GGI E+YQLPYYD
Sbjct: 371 HRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYD 430

Query: 341 MVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKK 400
           +VPSDPS+EEMRKVVC+QK RP+IPN+WQSCEALRVM +IMRECWYANGAARLTALRIKK
Sbjct: 431 LVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKK 490

Query: 401 TISQLCVKEDCK 412
           T+SQL  +E  K
Sbjct: 491 TLSQLSQQEGIK 502



 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 45/109 (41%), Positives = 53/109 (48%), Gaps = 15/109 (13%)

Query: 4   ALCSALRQALLLL------AAAAELSPG---LKCVCLLCDSSNFTCQTEGACWASVMLTN 54
           A  +A R  LLLL      AAAA L PG   L+C C LC   NFTC T+G C+ SV  T 
Sbjct: 3   AAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETT 62

Query: 55  GKEQVIKSCVS----LPELNAQVFCHSS--NNVTKTECCFTDFCNNITL 97
            K      C++    +P     V   SS   +VT T CC  D CN I L
Sbjct: 63  DKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIEL 111


>gi|4757720 activin A receptor, type IB isoform a precursor [Homo
           sapiens]
          Length = 505

 Score =  533 bits (1373), Expect = e-151
 Identities = 257/312 (82%), Positives = 285/312 (91%)

Query: 101 TGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQ 160
           +GLPL VQRT+ARTIVLQEI+GKGRFGEVW GRW G DVAVKIFSSR+ERSWFREAEIYQ
Sbjct: 193 SGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQ 252

Query: 161 TVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIA 220
           TVMLRHENILGFIAADNKDNGTWTQLWLVS+YHE GSL+DYLNR  VT+ GMIKLALS A
Sbjct: 253 TVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAA 312

Query: 221 SGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQN 280
           SGLAHLHMEIVGTQGKP IAHRD+KSKNILVKK   CAIADLGLAV+HD++ +TIDI  N
Sbjct: 313 SGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPN 372

Query: 281 PKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYD 340
            +VGTKRYMAPE+LD+T+N+  F+SFK ADIY++GLVYWEIARRC+ GG+ EEYQLPYYD
Sbjct: 373 QRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYD 432

Query: 341 MVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKK 400
           +VPSDPSIEEMRKVVCDQK RP+IPN WQS EALRVMG++MRECWYANGAARLTALRIKK
Sbjct: 433 LVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKK 492

Query: 401 TISQLCVKEDCK 412
           T+SQL V+ED K
Sbjct: 493 TLSQLSVQEDVK 504



 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 36/97 (37%), Positives = 55/97 (56%), Gaps = 7/97 (7%)

Query: 13  LLLLAAAAELSP----GLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVIKSCVSLPE 68
           +LLLA +    P     L C C  C  +N+TC+T+GAC  S+   +G E  +++C+   E
Sbjct: 15  VLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLDGMEHHVRTCIPKVE 74

Query: 69  L---NAQVFCHSSNNVTKTECCFTDFCNNITLHLPTG 102
           L       +C SS ++  T CC+TD+CN I L +P+G
Sbjct: 75  LVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSG 111


>gi|161333839 activin A receptor, type IC isoform 4 [Homo sapiens]
          Length = 336

 Score =  482 bits (1241), Expect = e-136
 Identities = 235/235 (100%), Positives = 235/235 (100%)

Query: 179 DNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQGKPA 238
           DNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQGKPA
Sbjct: 102 DNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQGKPA 161

Query: 239 IAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDDTM 298
           IAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDDTM
Sbjct: 162 IAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDDTM 221

Query: 299 NVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQ 358
           NVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQ
Sbjct: 222 NVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQ 281

Query: 359 KFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQLCVKEDCKA 413
           KFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQLCVKEDCKA
Sbjct: 282 KFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQLCVKEDCKA 336



 Score =  213 bits (541), Expect = 3e-55
 Identities = 101/101 (100%), Positives = 101/101 (100%)

Query: 1   MTRALCSALRQALLLLAAAAELSPGLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVI 60
           MTRALCSALRQALLLLAAAAELSPGLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVI
Sbjct: 1   MTRALCSALRQALLLLAAAAELSPGLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVI 60

Query: 61  KSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPT 101
           KSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPT
Sbjct: 61  KSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPT 101


>gi|33598910 activin A receptor, type IB isoform b precursor [Homo
           sapiens]
          Length = 476

 Score =  465 bits (1196), Expect = e-131
 Identities = 223/272 (81%), Positives = 247/272 (90%)

Query: 101 TGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQ 160
           +GLPL VQRT+ARTIVLQEI+GKGRFGEVW GRW G DVAVKIFSSR+ERSWFREAEIYQ
Sbjct: 193 SGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQ 252

Query: 161 TVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIA 220
           TVMLRHENILGFIAADNKDNGTWTQLWLVS+YHE GSL+DYLNR  VT+ GMIKLALS A
Sbjct: 253 TVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAA 312

Query: 221 SGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQN 280
           SGLAHLHMEIVGTQGKP IAHRD+KSKNILVKK   CAIADLGLAV+HD++ +TIDI  N
Sbjct: 313 SGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPN 372

Query: 281 PKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYD 340
            +VGTKRYMAPE+LD+T+N+  F+SFK ADIY++GLVYWEIARRC+ GG+ EEYQLPYYD
Sbjct: 373 QRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYD 432

Query: 341 MVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCE 372
           +VPSDPSIEEMRKVVCDQK RP+IPN WQS E
Sbjct: 433 LVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYE 464



 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 36/97 (37%), Positives = 55/97 (56%), Gaps = 7/97 (7%)

Query: 13  LLLLAAAAELSP----GLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVIKSCVSLPE 68
           +LLLA +    P     L C C  C  +N+TC+T+GAC  S+   +G E  +++C+   E
Sbjct: 15  VLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLDGMEHHVRTCIPKVE 74

Query: 69  L---NAQVFCHSSNNVTKTECCFTDFCNNITLHLPTG 102
           L       +C SS ++  T CC+TD+CN I L +P+G
Sbjct: 75  LVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSG 111


>gi|4502431 bone morphogenetic protein receptor, type IB precursor
           [Homo sapiens]
          Length = 502

 Score =  422 bits (1084), Expect = e-118
 Identities = 200/312 (64%), Positives = 247/312 (79%)

Query: 101 TGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQ 160
           +GLPLLVQRTIA+ I + + +GKGR+GEVW G+W GE VAVK+F + +E SWFRE EIYQ
Sbjct: 190 SGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQ 249

Query: 161 TVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIA 220
           TV++RHENILGFIAAD K  G+WTQL+L+++YHE GSLYDYL    +    M+KLA S  
Sbjct: 250 TVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSV 309

Query: 221 SGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQN 280
           SGL HLH EI  TQGKPAIAHRD+KSKNILVKK  TC IADLGLAVK  S  N +DIP N
Sbjct: 310 SGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPN 369

Query: 281 PKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYD 340
            +VGTKRYM PE+LD+++N N F+S+  AD+YS GL+ WE+ARRC  GGIVEEYQLPY+D
Sbjct: 370 TRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHD 429

Query: 341 MVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKK 400
           +VPSDPS E+MR++VC +K RPS PN+W S E LR MG++M ECW  N A+RLTALR+KK
Sbjct: 430 LVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKK 489

Query: 401 TISQLCVKEDCK 412
           T++++   +D K
Sbjct: 490 TLAKMSESQDIK 501


>gi|166235898 activin A receptor, type I precursor [Homo sapiens]
          Length = 509

 Score =  412 bits (1060), Expect = e-115
 Identities = 198/316 (62%), Positives = 245/316 (77%), Gaps = 5/316 (1%)

Query: 101 TGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQ 160
           +GLP LVQRT+AR I L E VGKGR+GEVW G W GE+VAVKIFSSRDE+SWFRE E+Y 
Sbjct: 194 SGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYN 253

Query: 161 TVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIA 220
           TVMLRHENILGFIA+D     + TQLWL++ YHE GSLYDYL    +     +++ LSIA
Sbjct: 254 TVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIA 313

Query: 221 SGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQN 280
           SGLAHLH+EI GTQGKPAIAHRD+KSKNILVKK   C IADLGLAV H    N +D+  N
Sbjct: 314 SGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNN 373

Query: 281 PKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYD 340
           P+VGTKRYMAPE+LD+T+ V+ F+S+KR DI++ GLV WE+ARR    GIVE+Y+ P+YD
Sbjct: 374 PRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYD 433

Query: 341 MVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKK 400
           +VP+DPS E+MRKVVC  + RP+IPN+W S   L  + ++M+ECWY N +ARLTALRIKK
Sbjct: 434 VVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKK 493

Query: 401 TISQL-----CVKEDC 411
           T++++      +K DC
Sbjct: 494 TLTKIDNSLDKLKTDC 509


>gi|4501895 activin A receptor, type I precursor [Homo sapiens]
          Length = 509

 Score =  412 bits (1060), Expect = e-115
 Identities = 198/316 (62%), Positives = 245/316 (77%), Gaps = 5/316 (1%)

Query: 101 TGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQ 160
           +GLP LVQRT+AR I L E VGKGR+GEVW G W GE+VAVKIFSSRDE+SWFRE E+Y 
Sbjct: 194 SGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYN 253

Query: 161 TVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIA 220
           TVMLRHENILGFIA+D     + TQLWL++ YHE GSLYDYL    +     +++ LSIA
Sbjct: 254 TVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIA 313

Query: 221 SGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQN 280
           SGLAHLH+EI GTQGKPAIAHRD+KSKNILVKK   C IADLGLAV H    N +D+  N
Sbjct: 314 SGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNN 373

Query: 281 PKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYD 340
           P+VGTKRYMAPE+LD+T+ V+ F+S+KR DI++ GLV WE+ARR    GIVE+Y+ P+YD
Sbjct: 374 PRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYD 433

Query: 341 MVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKK 400
           +VP+DPS E+MRKVVC  + RP+IPN+W S   L  + ++M+ECWY N +ARLTALRIKK
Sbjct: 434 VVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKK 493

Query: 401 TISQL-----CVKEDC 411
           T++++      +K DC
Sbjct: 494 TLTKIDNSLDKLKTDC 509


>gi|41349437 bone morphogenetic protein receptor, type IA precursor
           [Homo sapiens]
          Length = 532

 Score =  412 bits (1059), Expect = e-115
 Identities = 196/312 (62%), Positives = 246/312 (78%)

Query: 101 TGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQ 160
           +GLPLLVQRTIA+ I +   VGKGR+GEVW G+W GE VAVK+F + +E SWFRE EIYQ
Sbjct: 220 SGLPLLVQRTIAKQIQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQ 279

Query: 161 TVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIA 220
           TV++RHENILGFIAAD K  G+WTQL+L+++YHE GSLYD+L    +    ++KLA S A
Sbjct: 280 TVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAA 339

Query: 221 SGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQN 280
            GL HLH EI GTQGKPAIAHRD+KSKNIL+KK  +C IADLGLAVK +S  N +D+P N
Sbjct: 340 CGLCHLHTEIYGTQGKPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLN 399

Query: 281 PKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYD 340
            +VGTKRYMAPE+LD+++N N F+ +  ADIYS GL+ WE+ARRC  GGIVEEYQLPYY+
Sbjct: 400 TRVGTKRYMAPEVLDESLNKNHFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYN 459

Query: 341 MVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKK 400
           MVPSDPS E+MR+VVC ++ RP + N+W S E LR + ++M ECW  N A+RLTALRIKK
Sbjct: 460 MVPSDPSYEDMREVVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKK 519

Query: 401 TISQLCVKEDCK 412
           T++++   +D K
Sbjct: 520 TLAKMVESQDVK 531



 Score = 33.5 bits (75), Expect = 0.36
 Identities = 29/95 (30%), Positives = 43/95 (45%), Gaps = 8/95 (8%)

Query: 18  AAAELSPGLKCVCL-LC--DSSNFTCQTEGACWASVMLTN-GKEQVIKSCVSLPELNAQV 73
           A  +  P LKC C   C  D+ N TC T G C+A +   + G+  +   C+     + Q 
Sbjct: 51  APEDTLPFLKCYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQC 110

Query: 74  FCHSSNNVTKT-ECCFTDFCNNITLHLPTGLPLLV 107
                  + +T ECC T+ CN    +L   LP +V
Sbjct: 111 KDSPKAQLRRTIECCRTNLCNQ---YLQPTLPPVV 142


>gi|33598912 activin A receptor, type IB isoform c precursor [Homo
           sapiens]
          Length = 487

 Score =  388 bits (996), Expect = e-108
 Identities = 187/229 (81%), Positives = 208/229 (90%)

Query: 101 TGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQ 160
           +GLPL VQRT+ARTIVLQEI+GKGRFGEVW GRW G DVAVKIFSSR+ERSWFREAEIYQ
Sbjct: 193 SGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQ 252

Query: 161 TVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIA 220
           TVMLRHENILGFIAADNKDNGTWTQLWLVS+YHE GSL+DYLNR  VT+ GMIKLALS A
Sbjct: 253 TVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAA 312

Query: 221 SGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQN 280
           SGLAHLHMEIVGTQGKP IAHRD+KSKNILVKK   CAIADLGLAV+HD++ +TIDI  N
Sbjct: 313 SGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPN 372

Query: 281 PKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGG 329
            +VGTKRYMAPE+LD+T+N+  F+SFK ADIY++GLVYWEIARRC+ GG
Sbjct: 373 QRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSGG 421



 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 36/97 (37%), Positives = 55/97 (56%), Gaps = 7/97 (7%)

Query: 13  LLLLAAAAELSP----GLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVIKSCVSLPE 68
           +LLLA +    P     L C C  C  +N+TC+T+GAC  S+   +G E  +++C+   E
Sbjct: 15  VLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLDGMEHHVRTCIPKVE 74

Query: 69  L---NAQVFCHSSNNVTKTECCFTDFCNNITLHLPTG 102
           L       +C SS ++  T CC+TD+CN I L +P+G
Sbjct: 75  LVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSG 111


>gi|116734714 activin A receptor type II-like 1 [Homo sapiens]
          Length = 503

 Score =  385 bits (989), Expect = e-107
 Identities = 186/305 (60%), Positives = 233/305 (76%)

Query: 101 TGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQ 160
           +GLP LVQRT+AR + L E VGKGR+GEVW G W GE VAVKIFSSRDE+SWFRE EIY 
Sbjct: 188 SGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYN 247

Query: 161 TVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIA 220
           TV+LRH+NILGFIA+D     + TQLWL++ YHE GSLYD+L R  +     ++LA+S A
Sbjct: 248 TVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAA 307

Query: 221 SGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQN 280
            GLAHLH+EI GTQGKPAIAHRD KS+N+LVK    C IADLGLAV H    + +DI  N
Sbjct: 308 CGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNN 367

Query: 281 PKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYD 340
           P+VGTKRYMAPE+LD+ +  + FES+K  DI++ GLV WEIARR  V GIVE+Y+ P+YD
Sbjct: 368 PRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYD 427

Query: 341 MVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKK 400
           +VP+DPS E+M+KVVC  +  P+IPN+  +   L  + ++MRECWY N +ARLTALRIKK
Sbjct: 428 VVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKK 487

Query: 401 TISQL 405
           T+ ++
Sbjct: 488 TLQKI 492


>gi|116734712 activin A receptor type II-like 1 [Homo sapiens]
          Length = 503

 Score =  385 bits (989), Expect = e-107
 Identities = 186/305 (60%), Positives = 233/305 (76%)

Query: 101 TGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQ 160
           +GLP LVQRT+AR + L E VGKGR+GEVW G W GE VAVKIFSSRDE+SWFRE EIY 
Sbjct: 188 SGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYN 247

Query: 161 TVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIA 220
           TV+LRH+NILGFIA+D     + TQLWL++ YHE GSLYD+L R  +     ++LA+S A
Sbjct: 248 TVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAA 307

Query: 221 SGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQN 280
            GLAHLH+EI GTQGKPAIAHRD KS+N+LVK    C IADLGLAV H    + +DI  N
Sbjct: 308 CGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNN 367

Query: 281 PKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYD 340
           P+VGTKRYMAPE+LD+ +  + FES+K  DI++ GLV WEIARR  V GIVE+Y+ P+YD
Sbjct: 368 PRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYD 427

Query: 341 MVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKK 400
           +VP+DPS E+M+KVVC  +  P+IPN+  +   L  + ++MRECWY N +ARLTALRIKK
Sbjct: 428 VVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKK 487

Query: 401 TISQL 405
           T+ ++
Sbjct: 488 TLQKI 492


>gi|4501897 activin A receptor, type IIA precursor [Homo sapiens]
          Length = 513

 Score =  229 bits (585), Expect = 3e-60
 Identities = 122/296 (41%), Positives = 190/296 (64%), Gaps = 6/296 (2%)

Query: 113 RTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGF 172
           + + L E+  +GRFG VW  +   E VAVKIF  +D++SW  E E+Y    ++HENIL F
Sbjct: 190 KPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQF 249

Query: 173 IAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVG 232
           I A+ +       LWL++ +HE+GSL D+L  N+V+   +  +A ++A GLA+LH +I G
Sbjct: 250 IGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPG 309

Query: 233 TQG--KPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMA 290
            +   KPAI+HRDIKSKN+L+K   T  IAD GLA+K ++  +  D   + +VGT+RYMA
Sbjct: 310 LKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGD--THGQVGTRRYMA 367

Query: 291 PEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVG-GIVEEYQLPYYDMVPSDPSIE 349
           PE+L+  +N    ++F R D+Y++GLV WE+A RC+   G V+EY LP+ + +   PS+E
Sbjct: 368 PEVLEGAINFQ-RDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLE 426

Query: 350 EMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQL 405
           +M++VV  +K RP + + WQ    + ++   + ECW  +  ARL+A  + + I+Q+
Sbjct: 427 DMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERITQM 482


>gi|67782324 transforming growth factor, beta receptor II isoform B
           precursor [Homo sapiens]
          Length = 567

 Score =  223 bits (567), Expect = 3e-58
 Identities = 117/299 (39%), Positives = 179/299 (59%), Gaps = 9/299 (3%)

Query: 115 IVLQEIVGKGRFGEVWHGRWCG------EDVAVKIFSSRDERSWFREAEIYQTVMLRHEN 168
           I L  +VGKGRF EV+  +         E VAVKIF   +  SW  E +I+  + L+HEN
Sbjct: 244 IELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHEN 303

Query: 169 ILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHM 228
           IL F+ A+ +      Q WL++ +H +G+L +YL R++++   + KL  S+A G+AHLH 
Sbjct: 304 ILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHS 363

Query: 229 EIVGTQGKPA--IAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTK 286
           +     G+P   I HRD+KS NILVK   TC + D GL+++ D  L+  D+  + +VGT 
Sbjct: 364 DHTPC-GRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTA 422

Query: 287 RYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDP 346
           RYMAPE+L+  MN+   ESFK+ D+YS+ LV WE+  RC+  G V++Y+ P+   V   P
Sbjct: 423 RYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHP 482

Query: 347 SIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQL 405
            +E M+  V   + RP IP+ W + + ++++   + ECW  +  ARLTA  + +  S+L
Sbjct: 483 CVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSEL 541


>gi|67782326 transforming growth factor, beta receptor II isoform A
           precursor [Homo sapiens]
          Length = 592

 Score =  223 bits (567), Expect = 3e-58
 Identities = 117/299 (39%), Positives = 179/299 (59%), Gaps = 9/299 (3%)

Query: 115 IVLQEIVGKGRFGEVWHGRWCG------EDVAVKIFSSRDERSWFREAEIYQTVMLRHEN 168
           I L  +VGKGRF EV+  +         E VAVKIF   +  SW  E +I+  + L+HEN
Sbjct: 269 IELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHEN 328

Query: 169 ILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHM 228
           IL F+ A+ +      Q WL++ +H +G+L +YL R++++   + KL  S+A G+AHLH 
Sbjct: 329 ILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHS 388

Query: 229 EIVGTQGKPA--IAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTK 286
           +     G+P   I HRD+KS NILVK   TC + D GL+++ D  L+  D+  + +VGT 
Sbjct: 389 DHTPC-GRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTA 447

Query: 287 RYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDP 346
           RYMAPE+L+  MN+   ESFK+ D+YS+ LV WE+  RC+  G V++Y+ P+   V   P
Sbjct: 448 RYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHP 507

Query: 347 SIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQL 405
            +E M+  V   + RP IP+ W + + ++++   + ECW  +  ARLTA  + +  S+L
Sbjct: 508 CVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSEL 566


>gi|116734708 activin A receptor, type IIB precursor [Homo sapiens]
          Length = 512

 Score =  223 bits (567), Expect = 3e-58
 Identities = 121/314 (38%), Positives = 194/314 (61%), Gaps = 7/314 (2%)

Query: 94  NITLHLPTGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWF 153
           ++ +H   G P        + + L EI  +GRFG VW  +   + VAVKIF  +D++SW 
Sbjct: 169 HVDIHEDPGPPPPSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQ 228

Query: 154 REAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMI 213
            E EI+ T  ++HEN+L FIAA+ + +    +LWL++ +H++GSL DYL  NI+T   + 
Sbjct: 229 SEREIFSTPGMKHENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELC 288

Query: 214 KLALSIASGLAHLHMEIVGTQG---KPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDS 270
            +A +++ GL++LH ++   +G   KP+IAHRD KSKN+L+K   T  +AD GLAV+ + 
Sbjct: 289 HVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEP 348

Query: 271 ILNTIDIPQNPKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRC-SVGG 329
                D   + +VGT+RYMAPE+L+  +N    ++F R D+Y++GLV WE+  RC +  G
Sbjct: 349 GKPPGD--THGQVGTRRYMAPEVLEGAINFQ-RDAFLRIDMYAMGLVLWELVSRCKAADG 405

Query: 330 IVEEYQLPYYDMVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANG 389
            V+EY LP+ + +   PS+EE+++VV  +K RP+I + W     L  +   + ECW  + 
Sbjct: 406 PVDEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDA 465

Query: 390 AARLTALRIKKTIS 403
            ARL+A  +++ +S
Sbjct: 466 EARLSAGCVEERVS 479



 Score = 28.9 bits (63), Expect = 8.9
 Identities = 18/63 (28%), Positives = 27/63 (42%), Gaps = 12/63 (19%)

Query: 46  CWASVMLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTE--------CCFTDFCNNITL 97
           C+AS   ++G  +++K    L + N    C+       TE        CC  +FCN    
Sbjct: 59  CYASWRNSSGTIELVKKGCWLDDFN----CYDRQECVATEENPQVYFCCCEGNFCNERFT 114

Query: 98  HLP 100
           HLP
Sbjct: 115 HLP 117


>gi|15451916 bone morphogenetic protein receptor type II precursor
           [Homo sapiens]
          Length = 1038

 Score =  187 bits (474), Expect = 2e-47
 Identities = 111/302 (36%), Positives = 174/302 (57%), Gaps = 15/302 (4%)

Query: 117 LQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAAD 176
           L E++G+GR+G V+ G      VAVK+FS  + +++  E  IY+  ++ H+NI  FI  D
Sbjct: 205 LLELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIVGD 264

Query: 177 NKDNGTW-TQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIV-GTQ 234
            +       +  LV EY+  GSL  YL+ +        +LA S+  GLA+LH E+  G  
Sbjct: 265 ERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRGDH 324

Query: 235 GKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQN------PKVGTKRY 288
            KPAI+HRD+ S+N+LVK   TC I+D GL+++     N +  P         +VGT RY
Sbjct: 325 YKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTG--NRLVRPGEEDNAAISEVGTIRY 382

Query: 289 MAPEMLDDTMNVNIFES-FKRADIYSVGLVYWEIARRCS---VGGIVEEYQLPYYDMVPS 344
           MAPE+L+  +N+   ES  K+ D+Y++GL+YWEI  RC+    G  V EYQ+ +   V +
Sbjct: 383 MAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEYQMAFQTEVGN 442

Query: 345 DPSIEEMRKVVCDQKFRPSIPNQW-QSCEALRVMGRIMRECWYANGAARLTALRIKKTIS 403
            P+ E+M+ +V  +K RP  P  W ++  A+R +   + +CW  +  ARLTA   ++ ++
Sbjct: 443 HPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETIEDCWDQDAEARLTAQCAEERMA 502

Query: 404 QL 405
           +L
Sbjct: 503 EL 504


>gi|10198656 anti-Mullerian hormone receptor, type II [Homo sapiens]
          Length = 573

 Score =  159 bits (403), Expect = 3e-39
 Identities = 106/307 (34%), Positives = 167/307 (54%), Gaps = 17/307 (5%)

Query: 115 IVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIA 174
           +   +++ +G    VW G+  G+ VA+K F  R    +  E  +Y+   L+H++I+ FI 
Sbjct: 203 LCFSQVIREGGHAVVWAGQLQGKLVAIKAFPPRSVAQFQAERALYELPGLQHDHIVRFIT 262

Query: 175 ADNKDNGTWTQ-LWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEI-VG 232
           A     G       LV E H +GSL  YL +        +++ALS+A GLA LH E    
Sbjct: 263 ASRGGPGRLLSGPLLVLELHPKGSLCHYLTQYTSDWGSSLRMALSLAQGLAFLHEERWQN 322

Query: 233 TQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILN----TIDIPQNP----KVG 284
            Q KP IAHRD+ S+N+L+++  +CAI DLGLA+    +      T   PQ P    + G
Sbjct: 323 GQYKPGIAHRDLSSQNVLIREDGSCAIGDLGLALVLPGLTQPPAWTPTQPQGPAAIMEAG 382

Query: 285 TKRYMAPEMLDDTMNVNIF-ESFKRADIYSVGLVYWEIARRC---SVGGIVEEYQLPYYD 340
           T+RYMAPE+LD T+++  +  + +RADIYS+ L+ WEI  RC           +QL Y  
Sbjct: 383 TQRYMAPELLDKTLDLQDWGMALRRADIYSLALLLWEILSRCPDLRPDSSPPPFQLAYEA 442

Query: 341 MVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMG--RIMRECWYANGAARLTALRI 398
            + + P+ +E+  +   ++ RP IP+ W+ C A    G   ++ +CW A+  ARLTA  +
Sbjct: 443 ELGNTPTSDELWALAVQERRRPYIPSTWR-CFATDPDGLRELLEDCWDADPEARLTAECV 501

Query: 399 KKTISQL 405
           ++ ++ L
Sbjct: 502 QQRLAAL 508


>gi|187475373 c-src tyrosine kinase [Homo sapiens]
          Length = 450

 Score = 89.0 bits (219), Expect = 7e-18
 Identities = 75/301 (24%), Positives = 143/301 (47%), Gaps = 50/301 (16%)

Query: 113 RTIVLQEIVGKGRFGEVWHGRWCGEDVAVK-IFSSRDERSWFREAEIYQTVMLRHENILG 171
           + + L + +GKG FG+V  G + G  VAVK I +    +++  EA +     LRH N++ 
Sbjct: 193 KELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVM--TQLRHSNLVQ 250

Query: 172 FIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAG---MIKLALSIASGLAHLHM 228
            +    ++ G    L++V+EY  +GSL DYL     +V G   ++K +L +   + +L  
Sbjct: 251 LLGVIVEEKGG---LYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL-- 305

Query: 229 EIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRY 288
                +G   + HRD+ ++N+LV +     ++D GL  +  S  +T  +P        ++
Sbjct: 306 -----EGNNFV-HRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLP-------VKW 352

Query: 289 MAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSI 348
            APE L +       +   ++D++S G++ WEI       G V   ++P  D+V   P +
Sbjct: 353 TAPEALREK------KFSTKSDVWSFGILLWEIYS----FGRVPYPRIPLKDVV---PRV 399

Query: 349 EEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQLCVK 408
           E+  K+       P++               +M+ CW+ + A R + L++++ +  +   
Sbjct: 400 EKGYKMDAPDGCPPAV-------------YEVMKNCWHLDAAMRPSFLQLREQLEHIKTH 446

Query: 409 E 409
           E
Sbjct: 447 E 447


>gi|4758078 c-src tyrosine kinase [Homo sapiens]
          Length = 450

 Score = 89.0 bits (219), Expect = 7e-18
 Identities = 75/301 (24%), Positives = 143/301 (47%), Gaps = 50/301 (16%)

Query: 113 RTIVLQEIVGKGRFGEVWHGRWCGEDVAVK-IFSSRDERSWFREAEIYQTVMLRHENILG 171
           + + L + +GKG FG+V  G + G  VAVK I +    +++  EA +     LRH N++ 
Sbjct: 193 KELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVM--TQLRHSNLVQ 250

Query: 172 FIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAG---MIKLALSIASGLAHLHM 228
            +    ++ G    L++V+EY  +GSL DYL     +V G   ++K +L +   + +L  
Sbjct: 251 LLGVIVEEKGG---LYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL-- 305

Query: 229 EIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRY 288
                +G   + HRD+ ++N+LV +     ++D GL  +  S  +T  +P        ++
Sbjct: 306 -----EGNNFV-HRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLP-------VKW 352

Query: 289 MAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSI 348
            APE L +       +   ++D++S G++ WEI       G V   ++P  D+V   P +
Sbjct: 353 TAPEALREK------KFSTKSDVWSFGILLWEIYS----FGRVPYPRIPLKDVV---PRV 399

Query: 349 EEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQLCVK 408
           E+  K+       P++               +M+ CW+ + A R + L++++ +  +   
Sbjct: 400 EKGYKMDAPDGCPPAV-------------YEVMKNCWHLDAAMRPSFLQLREQLEHIKTH 446

Query: 409 E 409
           E
Sbjct: 447 E 447


>gi|19526767 MLK-related kinase isoform 2 [Homo sapiens]
          Length = 455

 Score = 82.0 bits (201), Expect = 9e-16
 Identities = 78/281 (27%), Positives = 131/281 (46%), Gaps = 57/281 (20%)

Query: 119 EIVGKGRFGEVWHGRWCGED--VAVKIFSSRDERSWFREAEIYQTVMLRHENILGF--IA 174
           E  G G FG V+  +W  +D  VAVK     +     +EAEI    +L H NI+ F  + 
Sbjct: 20  ENCGGGSFGSVYRAKWISQDKEVAVKKLLKIE-----KEAEILS--VLSHRNIIQFYGVI 72

Query: 175 ADNKDNGTWTQLWLVSEYHEQGSLYDYLNRN---IVTVAGMIKLALSIASGLAHLHMEIV 231
            +  + G      +V+EY   GSLYDY+N N    + +  ++  A  +A G+ +LHME  
Sbjct: 73  LEPPNYG------IVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHME-- 124

Query: 232 GTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAP 291
                  + HRD+KS+N+++       I D G +  H+   +         VGT  +MAP
Sbjct: 125 ---APVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHM------SLVGTFPWMAP 175

Query: 292 EMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSIEEM 351
           E++    ++ + E+    D YS G+V WE+  R          ++P+  +        ++
Sbjct: 176 EVI---QSLPVSET---CDTYSYGVVLWEMLTR----------EVPFKGLEGL-----QV 214

Query: 352 RKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAAR 392
             +V ++  R +IP+   SC   R    ++ +CW A+   R
Sbjct: 215 AWLVVEKNERLTIPS---SCP--RSFAELLHQCWEADAKKR 250


>gi|82880648 MLK-related kinase isoform 1 [Homo sapiens]
          Length = 800

 Score = 82.0 bits (201), Expect = 9e-16
 Identities = 78/281 (27%), Positives = 131/281 (46%), Gaps = 57/281 (20%)

Query: 119 EIVGKGRFGEVWHGRWCGED--VAVKIFSSRDERSWFREAEIYQTVMLRHENILGF--IA 174
           E  G G FG V+  +W  +D  VAVK     +     +EAEI    +L H NI+ F  + 
Sbjct: 20  ENCGGGSFGSVYRAKWISQDKEVAVKKLLKIE-----KEAEILS--VLSHRNIIQFYGVI 72

Query: 175 ADNKDNGTWTQLWLVSEYHEQGSLYDYLNRN---IVTVAGMIKLALSIASGLAHLHMEIV 231
            +  + G      +V+EY   GSLYDY+N N    + +  ++  A  +A G+ +LHME  
Sbjct: 73  LEPPNYG------IVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHME-- 124

Query: 232 GTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAP 291
                  + HRD+KS+N+++       I D G +  H+   +         VGT  +MAP
Sbjct: 125 ---APVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHM------SLVGTFPWMAP 175

Query: 292 EMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSIEEM 351
           E++    ++ + E+    D YS G+V WE+  R          ++P+  +        ++
Sbjct: 176 EVI---QSLPVSET---CDTYSYGVVLWEMLTR----------EVPFKGLEGL-----QV 214

Query: 352 RKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAAR 392
             +V ++  R +IP+   SC   R    ++ +CW A+   R
Sbjct: 215 AWLVVEKNERLTIPS---SCP--RSFAELLHQCWEADAKKR 250


>gi|4506401 v-raf-1 murine leukemia viral oncogene homolog 1 [Homo
           sapiens]
          Length = 648

 Score = 80.9 bits (198), Expect = 2e-15
 Identities = 71/215 (33%), Positives = 107/215 (49%), Gaps = 24/215 (11%)

Query: 112 ARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLR---HEN 168
           A  ++L   +G G FG V+ G+W G DVAVKI    D      +A   +  +LR   H N
Sbjct: 346 ASEVMLSTRIGSGSFGTVYKGKWHG-DVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVN 404

Query: 169 ILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLN--RNIVTVAGMIKLALSIASGLAHL 226
           IL F+    KDN     L +V+++ E  SLY +L+       +  +I +A   A G+ +L
Sbjct: 405 ILLFMGYMTKDN-----LAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYL 459

Query: 227 HMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTK 286
           H +         I HRD+KS NI + +  T  I D GLA        +  + Q    G+ 
Sbjct: 460 HAK--------NIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQ--PTGSV 509

Query: 287 RYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEI 321
            +MAPE++   M  N   SF ++D+YS G+V +E+
Sbjct: 510 LWMAPEVI--RMQDNNPFSF-QSDVYSYGIVLYEL 541


>gi|21735566 mitogen-activated protein kinase kinase kinase 7
           isoform D [Homo sapiens]
          Length = 491

 Score = 80.5 bits (197), Expect = 3e-15
 Identities = 64/217 (29%), Positives = 99/217 (45%), Gaps = 30/217 (13%)

Query: 113 RTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGF 172
           + I ++E+VG+G FG V   +W  +DVA+K   S  ER  F   E+ Q   + H NI+  
Sbjct: 34  KEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAF-IVELRQLSRVNHPNIVKL 92

Query: 173 IAADNKDNGTWTQLWLVSEYHEQGSLYDYLN----RNIVTVAGMIKLALSIASGLAHLHM 228
             A          + LV EY E GSLY+ L+        T A  +   L  + G+A+LH 
Sbjct: 93  YGA------CLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLH- 145

Query: 229 EIVGTQGKPAIAHRDIKSKNILVKKCET-CAIADLGLAVKHDSILNTIDIPQNPKVGTKR 287
               +    A+ HRD+K  N+L+    T   I D G A         I        G+  
Sbjct: 146 ----SMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC-------DIQTHMTNNKGSAA 194

Query: 288 YMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARR 324
           +MAPE+ + +         ++ D++S G++ WE+  R
Sbjct: 195 WMAPEVFEGS------NYSEKCDVFSWGIILWEVITR 225


>gi|21735564 mitogen-activated protein kinase kinase kinase 7
           isoform C [Homo sapiens]
          Length = 518

 Score = 80.5 bits (197), Expect = 3e-15
 Identities = 64/217 (29%), Positives = 99/217 (45%), Gaps = 30/217 (13%)

Query: 113 RTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGF 172
           + I ++E+VG+G FG V   +W  +DVA+K   S  ER  F   E+ Q   + H NI+  
Sbjct: 34  KEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAF-IVELRQLSRVNHPNIVKL 92

Query: 173 IAADNKDNGTWTQLWLVSEYHEQGSLYDYLN----RNIVTVAGMIKLALSIASGLAHLHM 228
             A          + LV EY E GSLY+ L+        T A  +   L  + G+A+LH 
Sbjct: 93  YGA------CLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLH- 145

Query: 229 EIVGTQGKPAIAHRDIKSKNILVKKCET-CAIADLGLAVKHDSILNTIDIPQNPKVGTKR 287
               +    A+ HRD+K  N+L+    T   I D G A         I        G+  
Sbjct: 146 ----SMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC-------DIQTHMTNNKGSAA 194

Query: 288 YMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARR 324
           +MAPE+ + +         ++ D++S G++ WE+  R
Sbjct: 195 WMAPEVFEGS------NYSEKCDVFSWGIILWEVITR 225


>gi|21735562 mitogen-activated protein kinase kinase kinase 7
           isoform B [Homo sapiens]
          Length = 606

 Score = 80.5 bits (197), Expect = 3e-15
 Identities = 64/217 (29%), Positives = 99/217 (45%), Gaps = 30/217 (13%)

Query: 113 RTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGF 172
           + I ++E+VG+G FG V   +W  +DVA+K   S  ER  F   E+ Q   + H NI+  
Sbjct: 34  KEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAF-IVELRQLSRVNHPNIVKL 92

Query: 173 IAADNKDNGTWTQLWLVSEYHEQGSLYDYLN----RNIVTVAGMIKLALSIASGLAHLHM 228
             A          + LV EY E GSLY+ L+        T A  +   L  + G+A+LH 
Sbjct: 93  YGA------CLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLH- 145

Query: 229 EIVGTQGKPAIAHRDIKSKNILVKKCET-CAIADLGLAVKHDSILNTIDIPQNPKVGTKR 287
               +    A+ HRD+K  N+L+    T   I D G A         I        G+  
Sbjct: 146 ----SMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC-------DIQTHMTNNKGSAA 194

Query: 288 YMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARR 324
           +MAPE+ + +         ++ D++S G++ WE+  R
Sbjct: 195 WMAPEVFEGS------NYSEKCDVFSWGIILWEVITR 225


>gi|4507361 mitogen-activated protein kinase kinase kinase 7 isoform
           A [Homo sapiens]
          Length = 579

 Score = 80.5 bits (197), Expect = 3e-15
 Identities = 64/217 (29%), Positives = 99/217 (45%), Gaps = 30/217 (13%)

Query: 113 RTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGF 172
           + I ++E+VG+G FG V   +W  +DVA+K   S  ER  F   E+ Q   + H NI+  
Sbjct: 34  KEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAF-IVELRQLSRVNHPNIVKL 92

Query: 173 IAADNKDNGTWTQLWLVSEYHEQGSLYDYLN----RNIVTVAGMIKLALSIASGLAHLHM 228
             A          + LV EY E GSLY+ L+        T A  +   L  + G+A+LH 
Sbjct: 93  YGA------CLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLH- 145

Query: 229 EIVGTQGKPAIAHRDIKSKNILVKKCET-CAIADLGLAVKHDSILNTIDIPQNPKVGTKR 287
               +    A+ HRD+K  N+L+    T   I D G A         I        G+  
Sbjct: 146 ----SMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC-------DIQTHMTNNKGSAA 194

Query: 288 YMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARR 324
           +MAPE+ + +         ++ D++S G++ WE+  R
Sbjct: 195 WMAPEVFEGS------NYSEKCDVFSWGIILWEVITR 225


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.135    0.423 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,477,022
Number of Sequences: 37866
Number of extensions: 657720
Number of successful extensions: 2619
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 190
Number of HSP's successfully gapped in prelim test: 482
Number of HSP's that attempted gapping in prelim test: 1721
Number of HSP's gapped (non-prelim): 747
length of query: 413
length of database: 18,247,518
effective HSP length: 105
effective length of query: 308
effective length of database: 14,271,588
effective search space: 4395649104
effective search space used: 4395649104
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.