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Search of human proteins with 161333835
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|161333835 activin A receptor, type IC isoform 2 [Homo
sapiens]
(443 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|161333835 activin A receptor, type IC isoform 2 [Homo sapiens] 905 0.0
gi|161333833 activin A receptor, type IC isoform 1 [Homo sapiens] 905 0.0
gi|161333837 activin A receptor, type IC isoform 3 [Homo sapiens] 639 0.0
gi|4759226 transforming growth factor, beta receptor I isoform 1... 623 e-179
gi|4757720 activin A receptor, type IB isoform a precursor [Homo... 613 e-176
gi|33598910 activin A receptor, type IB isoform b precursor [Hom... 545 e-155
gi|195963412 transforming growth factor, beta receptor I isoform... 537 e-153
gi|161333839 activin A receptor, type IC isoform 4 [Homo sapiens] 482 e-136
gi|33598912 activin A receptor, type IB isoform c precursor [Hom... 468 e-132
gi|4502431 bone morphogenetic protein receptor, type IB precurso... 449 e-126
gi|41349437 bone morphogenetic protein receptor, type IA precurs... 446 e-125
gi|166235898 activin A receptor, type I precursor [Homo sapiens] 445 e-125
gi|4501895 activin A receptor, type I precursor [Homo sapiens] 445 e-125
gi|116734714 activin A receptor type II-like 1 [Homo sapiens] 414 e-116
gi|116734712 activin A receptor type II-like 1 [Homo sapiens] 414 e-116
gi|4501897 activin A receptor, type IIA precursor [Homo sapiens] 235 5e-62
gi|116734708 activin A receptor, type IIB precursor [Homo sapiens] 233 3e-61
gi|67782324 transforming growth factor, beta receptor II isoform... 223 4e-58
gi|67782326 transforming growth factor, beta receptor II isoform... 223 4e-58
gi|15451916 bone morphogenetic protein receptor type II precurso... 197 2e-50
gi|10198656 anti-Mullerian hormone receptor, type II [Homo sapiens] 168 8e-42
gi|187475373 c-src tyrosine kinase [Homo sapiens] 89 8e-18
gi|4758078 c-src tyrosine kinase [Homo sapiens] 89 8e-18
gi|19526767 MLK-related kinase isoform 2 [Homo sapiens] 82 1e-15
gi|82880648 MLK-related kinase isoform 1 [Homo sapiens] 82 1e-15
gi|4506401 v-raf-1 murine leukemia viral oncogene homolog 1 [Hom... 81 2e-15
gi|21735566 mitogen-activated protein kinase kinase kinase 7 iso... 80 3e-15
gi|21735564 mitogen-activated protein kinase kinase kinase 7 iso... 80 3e-15
gi|21735562 mitogen-activated protein kinase kinase kinase 7 iso... 80 3e-15
gi|4507361 mitogen-activated protein kinase kinase kinase 7 isof... 80 3e-15
>gi|161333835 activin A receptor, type IC isoform 2 [Homo sapiens]
Length = 443
Score = 905 bits (2340), Expect = 0.0
Identities = 443/443 (100%), Positives = 443/443 (100%)
Query: 1 MLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPTASPNAPKLG 60
MLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPTASPNAPKLG
Sbjct: 1 MLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPTASPNAPKLG 60
Query: 61 PMELAIIITVPVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKTLKDL 120
PMELAIIITVPVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKTLKDL
Sbjct: 61 PMELAIIITVPVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKTLKDL 120
Query: 121 IYDVTASGSGSGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDER 180
IYDVTASGSGSGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDER
Sbjct: 121 IYDVTASGSGSGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDER 180
Query: 181 SWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVA 240
SWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVA
Sbjct: 181 SWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVA 240
Query: 241 GMIKLALSIASGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDS 300
GMIKLALSIASGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDS
Sbjct: 241 GMIKLALSIASGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDS 300
Query: 301 ILNTIDIPQNPKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGI 360
ILNTIDIPQNPKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGI
Sbjct: 301 ILNTIDIPQNPKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGI 360
Query: 361 VEEYQLPYYDMVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGA 420
VEEYQLPYYDMVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGA
Sbjct: 361 VEEYQLPYYDMVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGA 420
Query: 421 ARLTALRIKKTISQLCVKEDCKA 443
ARLTALRIKKTISQLCVKEDCKA
Sbjct: 421 ARLTALRIKKTISQLCVKEDCKA 443
>gi|161333833 activin A receptor, type IC isoform 1 [Homo sapiens]
Length = 493
Score = 905 bits (2340), Expect = 0.0
Identities = 443/443 (100%), Positives = 443/443 (100%)
Query: 1 MLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPTASPNAPKLG 60
MLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPTASPNAPKLG
Sbjct: 51 MLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPTASPNAPKLG 110
Query: 61 PMELAIIITVPVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKTLKDL 120
PMELAIIITVPVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKTLKDL
Sbjct: 111 PMELAIIITVPVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKTLKDL 170
Query: 121 IYDVTASGSGSGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDER 180
IYDVTASGSGSGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDER
Sbjct: 171 IYDVTASGSGSGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDER 230
Query: 181 SWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVA 240
SWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVA
Sbjct: 231 SWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVA 290
Query: 241 GMIKLALSIASGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDS 300
GMIKLALSIASGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDS
Sbjct: 291 GMIKLALSIASGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDS 350
Query: 301 ILNTIDIPQNPKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGI 360
ILNTIDIPQNPKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGI
Sbjct: 351 ILNTIDIPQNPKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGI 410
Query: 361 VEEYQLPYYDMVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGA 420
VEEYQLPYYDMVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGA
Sbjct: 411 VEEYQLPYYDMVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGA 470
Query: 421 ARLTALRIKKTISQLCVKEDCKA 443
ARLTALRIKKTISQLCVKEDCKA
Sbjct: 471 ARLTALRIKKTISQLCVKEDCKA 493
>gi|161333837 activin A receptor, type IC isoform 3 [Homo sapiens]
Length = 413
Score = 639 bits (1647), Expect = 0.0
Identities = 312/313 (99%), Positives = 313/313 (100%)
Query: 131 SGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQ 190
+GLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQ
Sbjct: 101 TGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQ 160
Query: 191 TVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIA 250
TVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIA
Sbjct: 161 TVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIA 220
Query: 251 SGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQN 310
SGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQN
Sbjct: 221 SGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQN 280
Query: 311 PKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYD 370
PKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYD
Sbjct: 281 PKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYD 340
Query: 371 MVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKK 430
MVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKK
Sbjct: 341 MVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKK 400
Query: 431 TISQLCVKEDCKA 443
TISQLCVKEDCKA
Sbjct: 401 TISQLCVKEDCKA 413
Score = 114 bits (285), Expect = 2e-25
Identities = 52/54 (96%), Positives = 52/54 (96%)
Query: 1 MLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPTASP 54
MLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPT P
Sbjct: 51 MLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPTGLP 104
>gi|4759226 transforming growth factor, beta receptor I isoform 1
precursor [Homo sapiens]
Length = 503
Score = 623 bits (1607), Expect = e-179
Identities = 307/415 (73%), Positives = 350/415 (84%), Gaps = 4/415 (0%)
Query: 28 SNNVTKTECCFTDFCNNITLHLPTASPNAPKLGPMELAIIITVPVCLLSIAAMLTVWACQ 87
+ +VT T CC D CN I LPT ++P LGP+ELA +I PVC + I+ ML V+ C
Sbjct: 92 TGSVTTTYCCNQDHCNKI--ELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICH 149
Query: 88 GRQCSYRKKKRPNVEEPLSECNLVNAGKTLKDLIYDVTASGSGSGLPLLVQRTIARTIVL 147
R + + PN E+P + ++ G TLKDLIYD+T SGSGSGLPLLVQRTIARTIVL
Sbjct: 150 NRTVIHHRV--PNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVL 207
Query: 148 QEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADN 207
QE +GKGRFGEVW G+W GE+VAVKIFSSR+ERSWFREAEIYQTVMLRHENILGFIAADN
Sbjct: 208 QESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADN 267
Query: 208 KDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQGKP 267
KDNGTWTQLWLVS+YHE GSL+DYLNR VTV GMIKLALS ASGLAHLHMEIVGTQGKP
Sbjct: 268 KDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKP 327
Query: 268 AIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDDT 327
AIAHRD+KSKNILVKK TC IADLGLAV+HDS +TIDI N +VGTKRYMAPE+LDD+
Sbjct: 328 AIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDS 387
Query: 328 MNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCD 387
+N+ FESFKRADIY++GLV+WEIARRCS+GGI E+YQLPYYD+VPSDPS+EEMRKVVC+
Sbjct: 388 INMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCE 447
Query: 388 QKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQLCVKEDCK 442
QK RP+IPN+WQSCEALRVM +IMRECWYANGAARLTALRIKKT+SQL +E K
Sbjct: 448 QKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIK 502
>gi|4757720 activin A receptor, type IB isoform a precursor [Homo
sapiens]
Length = 505
Score = 613 bits (1581), Expect = e-176
Identities = 306/446 (68%), Positives = 360/446 (80%), Gaps = 8/446 (1%)
Query: 4 NGKEQVIKSCVSLPEL---NAQVFCHSSNNVTKTECCFTDFCNNITLHLPTA---SPNAP 57
+G E +++C+ EL +C SS ++ T CC+TD+CN I L +P+ P P
Sbjct: 60 DGMEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHP 119
Query: 58 KL-GPMELAIIITVPVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKT 116
+ GP+EL II PV LL + ++ Q Y ++R ++E+P E L + KT
Sbjct: 120 SMWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCL-SKDKT 178
Query: 117 LKDLIYDVTASGSGSGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSS 176
L+DL+YD++ SGSGSGLPL VQRT+ARTIVLQEI+GKGRFGEVW GRW G DVAVKIFSS
Sbjct: 179 LQDLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSS 238
Query: 177 RDERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNI 236
R+ERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVS+YHE GSL+DYLNR
Sbjct: 239 REERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYT 298
Query: 237 VTVAGMIKLALSIASGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAV 296
VT+ GMIKLALS ASGLAHLHMEIVGTQGKP IAHRD+KSKNILVKK CAIADLGLAV
Sbjct: 299 VTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAV 358
Query: 297 KHDSILNTIDIPQNPKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCS 356
+HD++ +TIDI N +VGTKRYMAPE+LD+T+N+ F+SFK ADIY++GLVYWEIARRC+
Sbjct: 359 RHDAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCN 418
Query: 357 VGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWY 416
GG+ EEYQLPYYD+VPSDPSIEEMRKVVCDQK RP+IPN WQS EALRVMG++MRECWY
Sbjct: 419 SGGVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWY 478
Query: 417 ANGAARLTALRIKKTISQLCVKEDCK 442
ANGAARLTALRIKKT+SQL V+ED K
Sbjct: 479 ANGAARLTALRIKKTLSQLSVQEDVK 504
>gi|33598910 activin A receptor, type IB isoform b precursor [Homo
sapiens]
Length = 476
Score = 545 bits (1404), Expect = e-155
Identities = 272/406 (66%), Positives = 322/406 (79%), Gaps = 8/406 (1%)
Query: 4 NGKEQVIKSCVSLPEL---NAQVFCHSSNNVTKTECCFTDFCNNITLHLPTA---SPNAP 57
+G E +++C+ EL +C SS ++ T CC+TD+CN I L +P+ P P
Sbjct: 60 DGMEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHP 119
Query: 58 KL-GPMELAIIITVPVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKT 116
+ GP+EL II PV LL + ++ Q Y ++R ++E+P E L + KT
Sbjct: 120 SMWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCL-SKDKT 178
Query: 117 LKDLIYDVTASGSGSGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSS 176
L+DL+YD++ SGSGSGLPL VQRT+ARTIVLQEI+GKGRFGEVW GRW G DVAVKIFSS
Sbjct: 179 LQDLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSS 238
Query: 177 RDERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNI 236
R+ERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVS+YHE GSL+DYLNR
Sbjct: 239 REERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYT 298
Query: 237 VTVAGMIKLALSIASGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAV 296
VT+ GMIKLALS ASGLAHLHMEIVGTQGKP IAHRD+KSKNILVKK CAIADLGLAV
Sbjct: 299 VTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAV 358
Query: 297 KHDSILNTIDIPQNPKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCS 356
+HD++ +TIDI N +VGTKRYMAPE+LD+T+N+ F+SFK ADIY++GLVYWEIARRC+
Sbjct: 359 RHDAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCN 418
Query: 357 VGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCE 402
GG+ EEYQLPYYD+VPSDPSIEEMRKVVCDQK RP+IPN WQS E
Sbjct: 419 SGGVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYE 464
>gi|195963412 transforming growth factor, beta receptor I isoform 2
precursor [Homo sapiens]
Length = 426
Score = 537 bits (1383), Expect = e-153
Identities = 259/312 (83%), Positives = 287/312 (91%)
Query: 131 SGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQ 190
+GLPLLVQRTIARTIVLQE +GKGRFGEVW G+W GE+VAVKIFSSR+ERSWFREAEIYQ
Sbjct: 114 TGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQ 173
Query: 191 TVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIA 250
TVMLRHENILGFIAADNKDNGTWTQLWLVS+YHE GSL+DYLNR VTV GMIKLALS A
Sbjct: 174 TVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTA 233
Query: 251 SGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQN 310
SGLAHLHMEIVGTQGKPAIAHRD+KSKNILVKK TC IADLGLAV+HDS +TIDI N
Sbjct: 234 SGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPN 293
Query: 311 PKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYD 370
+VGTKRYMAPE+LDD++N+ FESFKRADIY++GLV+WEIARRCS+GGI E+YQLPYYD
Sbjct: 294 HRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYD 353
Query: 371 MVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKK 430
+VPSDPS+EEMRKVVC+QK RP+IPN+WQSCEALRVM +IMRECWYANGAARLTALRIKK
Sbjct: 354 LVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKK 413
Query: 431 TISQLCVKEDCK 442
T+SQL +E K
Sbjct: 414 TLSQLSQQEGIK 425
>gi|161333839 activin A receptor, type IC isoform 4 [Homo sapiens]
Length = 336
Score = 482 bits (1241), Expect = e-136
Identities = 235/235 (100%), Positives = 235/235 (100%)
Query: 209 DNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQGKPA 268
DNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQGKPA
Sbjct: 102 DNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQGKPA 161
Query: 269 IAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDDTM 328
IAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDDTM
Sbjct: 162 IAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDDTM 221
Query: 329 NVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQ 388
NVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQ
Sbjct: 222 NVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQ 281
Query: 389 KFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQLCVKEDCKA 443
KFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQLCVKEDCKA
Sbjct: 282 KFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQLCVKEDCKA 336
Score = 112 bits (280), Expect = 7e-25
Identities = 51/51 (100%), Positives = 51/51 (100%)
Query: 1 MLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPT 51
MLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPT
Sbjct: 51 MLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPT 101
>gi|33598912 activin A receptor, type IB isoform c precursor [Homo
sapiens]
Length = 487
Score = 468 bits (1204), Expect = e-132
Identities = 236/363 (65%), Positives = 283/363 (77%), Gaps = 8/363 (2%)
Query: 4 NGKEQVIKSCVSLPEL---NAQVFCHSSNNVTKTECCFTDFCNNITLHLPTA---SPNAP 57
+G E +++C+ EL +C SS ++ T CC+TD+CN I L +P+ P P
Sbjct: 60 DGMEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHP 119
Query: 58 KL-GPMELAIIITVPVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKT 116
+ GP+EL II PV LL + ++ Q Y ++R ++E+P E L + KT
Sbjct: 120 SMWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCL-SKDKT 178
Query: 117 LKDLIYDVTASGSGSGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSS 176
L+DL+YD++ SGSGSGLPL VQRT+ARTIVLQEI+GKGRFGEVW GRW G DVAVKIFSS
Sbjct: 179 LQDLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSS 238
Query: 177 RDERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNI 236
R+ERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVS+YHE GSL+DYLNR
Sbjct: 239 REERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYT 298
Query: 237 VTVAGMIKLALSIASGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAV 296
VT+ GMIKLALS ASGLAHLHMEIVGTQGKP IAHRD+KSKNILVKK CAIADLGLAV
Sbjct: 299 VTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAV 358
Query: 297 KHDSILNTIDIPQNPKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCS 356
+HD++ +TIDI N +VGTKRYMAPE+LD+T+N+ F+SFK ADIY++GLVYWEIARRC+
Sbjct: 359 RHDAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCN 418
Query: 357 VGG 359
GG
Sbjct: 419 SGG 421
>gi|4502431 bone morphogenetic protein receptor, type IB precursor
[Homo sapiens]
Length = 502
Score = 449 bits (1155), Expect = e-126
Identities = 234/413 (56%), Positives = 296/413 (71%), Gaps = 10/413 (2%)
Query: 35 ECCFTDFCNNITLHLPTASPNAPKL---GPME-LAIIITVPVCLLSIAAMLTVWACQGRQ 90
ECC N LH PT P + GP+ A++I+V VC S+ +L + C R
Sbjct: 94 ECCTERNECNKDLH-PTLPPLKNRDFVDGPIHHRALLISVTVC--SLLLVLIILFCYFRY 150
Query: 91 CSYRKKKRPNVEEPLSECNL-VNAGKTLKDLIYDVTASGSGSGLPLLVQRTIARTIVLQE 149
R++ RP L + + G++L+DLI +SGSGSGLPLLVQRTIA+ I + +
Sbjct: 151 --KRQETRPRYSIGLEQDETYIPPGESLRDLIEQSQSSGSGSGLPLLVQRTIAKQIQMVK 208
Query: 150 IVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADNKD 209
+GKGR+GEVW G+W GE VAVK+F + +E SWFRE EIYQTV++RHENILGFIAAD K
Sbjct: 209 QIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKG 268
Query: 210 NGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQGKPAI 269
G+WTQL+L+++YHE GSLYDYL + M+KLA S SGL HLH EI TQGKPAI
Sbjct: 269 TGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAI 328
Query: 270 AHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDDTMN 329
AHRD+KSKNILVKK TC IADLGLAVK S N +DIP N +VGTKRYM PE+LD+++N
Sbjct: 329 AHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPEVLDESLN 388
Query: 330 VNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQK 389
N F+S+ AD+YS GL+ WE+ARRC GGIVEEYQLPY+D+VPSDPS E+MR++VC +K
Sbjct: 389 RNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPSYEDMREIVCIKK 448
Query: 390 FRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQLCVKEDCK 442
RPS PN+W S E LR MG++M ECW N A+RLTALR+KKT++++ +D K
Sbjct: 449 LRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTLAKMSESQDIK 501
>gi|41349437 bone morphogenetic protein receptor, type IA precursor
[Homo sapiens]
Length = 532
Score = 446 bits (1148), Expect = e-125
Identities = 228/415 (54%), Positives = 296/415 (71%), Gaps = 13/415 (3%)
Query: 35 ECCFTDFCNNITLHLPTASPNAPKLGPME------LAIIITVPVCLLSIAAMLTVWACQG 88
ECC T+ CN PT P +GP L ++I++ VC++++ + + C
Sbjct: 123 ECCRTNLCNQYLQ--PTLPPVV--IGPFFDGSIRWLVLLISMAVCIIAMIIFSSCF-CYK 177
Query: 89 RQC-SYRKKKRPNVEEPLSECNLVNAGKTLKDLIYDVTASGSGSGLPLLVQRTIARTIVL 147
C S ++R N + E + G++LKDLI +SGSGSGLPLLVQRTIA+ I +
Sbjct: 178 HYCKSISSRRRYNRDLEQDEA-FIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQM 236
Query: 148 QEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADN 207
VGKGR+GEVW G+W GE VAVK+F + +E SWFRE EIYQTV++RHENILGFIAAD
Sbjct: 237 VRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADI 296
Query: 208 KDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQGKP 267
K G+WTQL+L+++YHE GSLYD+L + ++KLA S A GL HLH EI GTQGKP
Sbjct: 297 KGTGSWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQGKP 356
Query: 268 AIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDDT 327
AIAHRD+KSKNIL+KK +C IADLGLAVK +S N +D+P N +VGTKRYMAPE+LD++
Sbjct: 357 AIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEVLDES 416
Query: 328 MNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCD 387
+N N F+ + ADIYS GL+ WE+ARRC GGIVEEYQLPYY+MVPSDPS E+MR+VVC
Sbjct: 417 LNKNHFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREVVCV 476
Query: 388 QKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQLCVKEDCK 442
++ RP + N+W S E LR + ++M ECW N A+RLTALRIKKT++++ +D K
Sbjct: 477 KRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTLAKMVESQDVK 531
>gi|166235898 activin A receptor, type I precursor [Homo sapiens]
Length = 509
Score = 445 bits (1144), Expect = e-125
Identities = 227/418 (54%), Positives = 289/418 (69%), Gaps = 11/418 (2%)
Query: 35 ECCFTDFCN-NITLHLPTASPNAPKLGPMELAIIITVPVCLLSIAAMLTVWACQGRQCSY 93
ECC D+CN NIT LPT + P L + + + + ++ + + R+
Sbjct: 92 ECCQGDWCNRNITAQLPTKGKSFPGTQNFHLEVGLIILSVVFAVCLLACLLGVALRKFKR 151
Query: 94 RKKKRPNVEE----PLSECNLVNAG-KTLKDLIYDVTASGSGSGLPLLVQRTIARTIVLQ 148
R ++R N + + N G TL DL+ SGSGSGLP LVQRT+AR I L
Sbjct: 152 RNQERLNPRDVEYGTIEGLITTNVGDSTLADLLDHSCTSGSGSGLPFLVQRTVARQITLL 211
Query: 149 EIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADNK 208
E VGKGR+GEVW G W GE+VAVKIFSSRDE+SWFRE E+Y TVMLRHENILGFIA+D
Sbjct: 212 ECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMT 271
Query: 209 DNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQGKPA 268
+ TQLWL++ YHE GSLYDYL + +++ LSIASGLAHLH+EI GTQGKPA
Sbjct: 272 SRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPA 331
Query: 269 IAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDDTM 328
IAHRD+KSKNILVKK C IADLGLAV H N +D+ NP+VGTKRYMAPE+LD+T+
Sbjct: 332 IAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETI 391
Query: 329 NVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQ 388
V+ F+S+KR DI++ GLV WE+ARR GIVE+Y+ P+YD+VP+DPS E+MRKVVC
Sbjct: 392 QVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVD 451
Query: 389 KFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQL-----CVKEDC 441
+ RP+IPN+W S L + ++M+ECWY N +ARLTALRIKKT++++ +K DC
Sbjct: 452 QQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNSLDKLKTDC 509
>gi|4501895 activin A receptor, type I precursor [Homo sapiens]
Length = 509
Score = 445 bits (1144), Expect = e-125
Identities = 227/418 (54%), Positives = 289/418 (69%), Gaps = 11/418 (2%)
Query: 35 ECCFTDFCN-NITLHLPTASPNAPKLGPMELAIIITVPVCLLSIAAMLTVWACQGRQCSY 93
ECC D+CN NIT LPT + P L + + + + ++ + + R+
Sbjct: 92 ECCQGDWCNRNITAQLPTKGKSFPGTQNFHLEVGLIILSVVFAVCLLACLLGVALRKFKR 151
Query: 94 RKKKRPNVEE----PLSECNLVNAG-KTLKDLIYDVTASGSGSGLPLLVQRTIARTIVLQ 148
R ++R N + + N G TL DL+ SGSGSGLP LVQRT+AR I L
Sbjct: 152 RNQERLNPRDVEYGTIEGLITTNVGDSTLADLLDHSCTSGSGSGLPFLVQRTVARQITLL 211
Query: 149 EIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADNK 208
E VGKGR+GEVW G W GE+VAVKIFSSRDE+SWFRE E+Y TVMLRHENILGFIA+D
Sbjct: 212 ECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMT 271
Query: 209 DNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQGKPA 268
+ TQLWL++ YHE GSLYDYL + +++ LSIASGLAHLH+EI GTQGKPA
Sbjct: 272 SRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPA 331
Query: 269 IAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDDTM 328
IAHRD+KSKNILVKK C IADLGLAV H N +D+ NP+VGTKRYMAPE+LD+T+
Sbjct: 332 IAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETI 391
Query: 329 NVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQ 388
V+ F+S+KR DI++ GLV WE+ARR GIVE+Y+ P+YD+VP+DPS E+MRKVVC
Sbjct: 392 QVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVD 451
Query: 389 KFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQL-----CVKEDC 441
+ RP+IPN+W S L + ++M+ECWY N +ARLTALRIKKT++++ +K DC
Sbjct: 452 QQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNSLDKLKTDC 509
>gi|116734714 activin A receptor type II-like 1 [Homo sapiens]
Length = 503
Score = 414 bits (1065), Expect = e-116
Identities = 216/409 (52%), Positives = 283/409 (69%), Gaps = 14/409 (3%)
Query: 36 CCFTDFCN-NITLHLPTASPNAPKLGPM-ELAIIITVPVCLLSIAAM--LTVWACQGRQC 91
CC + CN N++L L P + + G +LA+I+ + LL++ A+ L +W + RQ
Sbjct: 89 CCDSHLCNHNVSLVLEATQPPSEQPGTDGQLALILGPVLALLALVALGVLGLWHVRRRQ- 147
Query: 92 SYRKKKRPNVEEPLSECNLV-----NAGKTLKDLIYDVTASGSGSGLPLLVQRTIARTIV 146
+K+ + L E +L+ L DL+ +GSGSGLP LVQRT+AR +
Sbjct: 148 ----EKQRGLHSELGESSLILKASEQGDSMLGDLLDSDCTTGSGSGLPFLVQRTVARQVA 203
Query: 147 LQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAAD 206
L E VGKGR+GEVW G W GE VAVKIFSSRDE+SWFRE EIY TV+LRH+NILGFIA+D
Sbjct: 204 LVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASD 263
Query: 207 NKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQGK 266
+ TQLWL++ YHE GSLYD+L R + ++LA+S A GLAHLH+EI GTQGK
Sbjct: 264 MTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFGTQGK 323
Query: 267 PAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDD 326
PAIAHRD KS+N+LVK C IADLGLAV H + +DI NP+VGTKRYMAPE+LD+
Sbjct: 324 PAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLDE 383
Query: 327 TMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSIEEMRKVVC 386
+ + FES+K DI++ GLV WEIARR V GIVE+Y+ P+YD+VP+DPS E+M+KVVC
Sbjct: 384 QIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVC 443
Query: 387 DQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQL 435
+ P+IPN+ + L + ++MRECWY N +ARLTALRIKKT+ ++
Sbjct: 444 VDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKI 492
>gi|116734712 activin A receptor type II-like 1 [Homo sapiens]
Length = 503
Score = 414 bits (1065), Expect = e-116
Identities = 216/409 (52%), Positives = 283/409 (69%), Gaps = 14/409 (3%)
Query: 36 CCFTDFCN-NITLHLPTASPNAPKLGPM-ELAIIITVPVCLLSIAAM--LTVWACQGRQC 91
CC + CN N++L L P + + G +LA+I+ + LL++ A+ L +W + RQ
Sbjct: 89 CCDSHLCNHNVSLVLEATQPPSEQPGTDGQLALILGPVLALLALVALGVLGLWHVRRRQ- 147
Query: 92 SYRKKKRPNVEEPLSECNLV-----NAGKTLKDLIYDVTASGSGSGLPLLVQRTIARTIV 146
+K+ + L E +L+ L DL+ +GSGSGLP LVQRT+AR +
Sbjct: 148 ----EKQRGLHSELGESSLILKASEQGDSMLGDLLDSDCTTGSGSGLPFLVQRTVARQVA 203
Query: 147 LQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAAD 206
L E VGKGR+GEVW G W GE VAVKIFSSRDE+SWFRE EIY TV+LRH+NILGFIA+D
Sbjct: 204 LVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASD 263
Query: 207 NKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQGK 266
+ TQLWL++ YHE GSLYD+L R + ++LA+S A GLAHLH+EI GTQGK
Sbjct: 264 MTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFGTQGK 323
Query: 267 PAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDD 326
PAIAHRD KS+N+LVK C IADLGLAV H + +DI NP+VGTKRYMAPE+LD+
Sbjct: 324 PAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLDE 383
Query: 327 TMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSIEEMRKVVC 386
+ + FES+K DI++ GLV WEIARR V GIVE+Y+ P+YD+VP+DPS E+M+KVVC
Sbjct: 384 QIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVC 443
Query: 387 DQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQL 435
+ P+IPN+ + L + ++MRECWY N +ARLTALRIKKT+ ++
Sbjct: 444 VDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKI 492
>gi|4501897 activin A receptor, type IIA precursor [Homo sapiens]
Length = 513
Score = 235 bits (600), Expect = 5e-62
Identities = 143/410 (34%), Positives = 226/410 (55%), Gaps = 41/410 (10%)
Query: 36 CCFTDFCNN-------ITLHLPTASPNAPKLGPMELAIIITVPVCLLSIAAMLTVWACQG 88
CC + CN + + PT++P PK + + VP+ L++ + W +
Sbjct: 104 CCEGNMCNEKFSYFPEMEVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRH 163
Query: 89 RQCSYRKKKRPNVEEPLSECNLVNAGKTLKDLIYDVTASGSGSGLPLLVQRTIARTIVLQ 148
+ +Y P V P + G PLL + + L
Sbjct: 164 HKMAY-----PPVLVPTQD-------------------PGPPPPSPLLGLKPLQ----LL 195
Query: 149 EIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADNK 208
E+ +GRFG VW + E VAVKIF +D++SW E E+Y ++HENIL FI A+ +
Sbjct: 196 EVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKR 255
Query: 209 DNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQG--K 266
LWL++ +HE+GSL D+L N+V+ + +A ++A GLA+LH +I G + K
Sbjct: 256 GTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHK 315
Query: 267 PAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDD 326
PAI+HRDIKSKN+L+K T IAD GLA+K ++ + D + +VGT+RYMAPE+L+
Sbjct: 316 PAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGD--THGQVGTRRYMAPEVLEG 373
Query: 327 TMNVNIFESFKRADIYSVGLVYWEIARRCSVG-GIVEEYQLPYYDMVPSDPSIEEMRKVV 385
+N ++F R D+Y++GLV WE+A RC+ G V+EY LP+ + + PS+E+M++VV
Sbjct: 374 AINFQ-RDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVV 432
Query: 386 CDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQL 435
+K RP + + WQ + ++ + ECW + ARL+A + + I+Q+
Sbjct: 433 VHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERITQM 482
>gi|116734708 activin A receptor, type IIB precursor [Homo sapiens]
Length = 512
Score = 233 bits (593), Expect = 3e-61
Identities = 148/436 (33%), Positives = 229/436 (52%), Gaps = 57/436 (13%)
Query: 11 KSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPTAS---------PNAPKLGP 61
+ CV+ E FC CC +FCN HLP A P AP L
Sbjct: 88 QECVATEENPQVYFC----------CCEGNFCNERFTHLPEAGGPEVTYEPPPTAPTL-- 135
Query: 62 MELAIIITVPVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKTLKDLI 121
+ + +P+ LS+ +L W YR +K P + E
Sbjct: 136 LTVLAYSLLPIGGLSLIVLLAFWM-------YRHRKPPYGHVDIHE-------------- 174
Query: 122 YDVTASGSGSGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERS 181
G P + + L EI +GRFG VW + + VAVKIF +D++S
Sbjct: 175 --------DPGPPPPSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQS 226
Query: 182 WFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAG 241
W E EI+ T ++HEN+L FIAA+ + + +LWL++ +H++GSL DYL NI+T
Sbjct: 227 WQSEREIFSTPGMKHENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNE 286
Query: 242 MIKLALSIASGLAHLHMEIVGTQG---KPAIAHRDIKSKNILVKKCETCAIADLGLAVKH 298
+ +A +++ GL++LH ++ +G KP+IAHRD KSKN+L+K T +AD GLAV+
Sbjct: 287 LCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRF 346
Query: 299 DSILNTIDIPQNPKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRC-SV 357
+ D + +VGT+RYMAPE+L+ +N ++F R D+Y++GLV WE+ RC +
Sbjct: 347 EPGKPPGD--THGQVGTRRYMAPEVLEGAINFQ-RDAFLRIDMYAMGLVLWELVSRCKAA 403
Query: 358 GGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYA 417
G V+EY LP+ + + PS+EE+++VV +K RP+I + W L + + ECW
Sbjct: 404 DGPVDEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDH 463
Query: 418 NGAARLTALRIKKTIS 433
+ ARL+A +++ +S
Sbjct: 464 DAEARLSAGCVEERVS 479
>gi|67782324 transforming growth factor, beta receptor II isoform B
precursor [Homo sapiens]
Length = 567
Score = 223 bits (567), Expect = 4e-58
Identities = 117/299 (39%), Positives = 179/299 (59%), Gaps = 9/299 (3%)
Query: 145 IVLQEIVGKGRFGEVWHGRWCG------EDVAVKIFSSRDERSWFREAEIYQTVMLRHEN 198
I L +VGKGRF EV+ + E VAVKIF + SW E +I+ + L+HEN
Sbjct: 244 IELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHEN 303
Query: 199 ILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHM 258
IL F+ A+ + Q WL++ +H +G+L +YL R++++ + KL S+A G+AHLH
Sbjct: 304 ILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHS 363
Query: 259 EIVGTQGKPA--IAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTK 316
+ G+P I HRD+KS NILVK TC + D GL+++ D L+ D+ + +VGT
Sbjct: 364 DHTPC-GRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTA 422
Query: 317 RYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDP 376
RYMAPE+L+ MN+ ESFK+ D+YS+ LV WE+ RC+ G V++Y+ P+ V P
Sbjct: 423 RYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHP 482
Query: 377 SIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQL 435
+E M+ V + RP IP+ W + + ++++ + ECW + ARLTA + + S+L
Sbjct: 483 CVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSEL 541
>gi|67782326 transforming growth factor, beta receptor II isoform A
precursor [Homo sapiens]
Length = 592
Score = 223 bits (567), Expect = 4e-58
Identities = 117/299 (39%), Positives = 179/299 (59%), Gaps = 9/299 (3%)
Query: 145 IVLQEIVGKGRFGEVWHGRWCG------EDVAVKIFSSRDERSWFREAEIYQTVMLRHEN 198
I L +VGKGRF EV+ + E VAVKIF + SW E +I+ + L+HEN
Sbjct: 269 IELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHEN 328
Query: 199 ILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHM 258
IL F+ A+ + Q WL++ +H +G+L +YL R++++ + KL S+A G+AHLH
Sbjct: 329 ILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHS 388
Query: 259 EIVGTQGKPA--IAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTK 316
+ G+P I HRD+KS NILVK TC + D GL+++ D L+ D+ + +VGT
Sbjct: 389 DHTPC-GRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTA 447
Query: 317 RYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDP 376
RYMAPE+L+ MN+ ESFK+ D+YS+ LV WE+ RC+ G V++Y+ P+ V P
Sbjct: 448 RYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHP 507
Query: 377 SIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQL 435
+E M+ V + RP IP+ W + + ++++ + ECW + ARLTA + + S+L
Sbjct: 508 CVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSEL 566
>gi|15451916 bone morphogenetic protein receptor type II precursor
[Homo sapiens]
Length = 1038
Score = 197 bits (500), Expect = 2e-50
Identities = 136/417 (32%), Positives = 213/417 (51%), Gaps = 46/417 (11%)
Query: 36 CCFTDFCN-NITLHLPTASPNAPKLGP---MELAIIITVPVCLLSIAAMLTVWACQGRQC 91
CC TD CN N T + P P+ L P I + + +S+ A+L V C G +
Sbjct: 117 CCSTDLCNVNFTENFPP--PDTTPLSPPHSFNRDETIIIALASVSVLAVLIVALCFGYRM 174
Query: 92 SYRKKKRPNVEEPLSECNLVNAGKTLKDLIYDVTASGSGSGLPLLVQRTIARTIVLQEIV 151
+K + L N++ A + L D + L E++
Sbjct: 175 LTGDRK-----QGLHSMNMMEAAASEPSLDLD--------------------NLKLLELI 209
Query: 152 GKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADNKDNG 211
G+GR+G V+ G VAVK+FS + +++ E IY+ ++ H+NI FI D +
Sbjct: 210 GRGRYGAVYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIVGDERVTA 269
Query: 212 TW-TQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIV-GTQGKPAI 269
+ LV EY+ GSL YL+ + +LA S+ GLA+LH E+ G KPAI
Sbjct: 270 DGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRGDHYKPAI 329
Query: 270 AHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQN------PKVGTKRYMAPEM 323
+HRD+ S+N+LVK TC I+D GL+++ N + P +VGT RYMAPE+
Sbjct: 330 SHRDLNSRNVLVKNDGTCVISDFGLSMRLTG--NRLVRPGEEDNAAISEVGTIRYMAPEV 387
Query: 324 LDDTMNVNIFES-FKRADIYSVGLVYWEIARRCS---VGGIVEEYQLPYYDMVPSDPSIE 379
L+ +N+ ES K+ D+Y++GL+YWEI RC+ G V EYQ+ + V + P+ E
Sbjct: 388 LEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEYQMAFQTEVGNHPTFE 447
Query: 380 EMRKVVCDQKFRPSIPNQW-QSCEALRVMGRIMRECWYANGAARLTALRIKKTISQL 435
+M+ +V +K RP P W ++ A+R + + +CW + ARLTA ++ +++L
Sbjct: 448 DMQVLVSREKQRPKFPEAWKENSLAVRSLKETIEDCWDQDAEARLTAQCAEERMAEL 504
>gi|10198656 anti-Mullerian hormone receptor, type II [Homo sapiens]
Length = 573
Score = 168 bits (426), Expect = 8e-42
Identities = 137/436 (31%), Positives = 210/436 (48%), Gaps = 52/436 (11%)
Query: 26 HSSNNVTKTEC-CFTDFCNNITLHLP------TASPNAPKLGPME---LAIIITVPVCLL 75
H S T C C TDFCN HLP T P+ P E +A+++ LL
Sbjct: 99 HPSPGSTLFTCSCGTDFCNANYSHLPPPGSPGTPGSQGPQAAPGESIWMALVLLGLFLLL 158
Query: 76 SIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKTLKDLIYDVTASGSGSGLPL 135
+ + A R+ +YR + P V EP + SG
Sbjct: 159 LLLLGSIILALLQRK-NYRVRGEP-VPEPRPD-----------------------SGRDW 193
Query: 136 LVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLR 195
V+ + +++ +G VW G+ G+ VA+K F R + E +Y+ L+
Sbjct: 194 SVELQELPELCFSQVIREGGHAVVWAGQLQGKLVAIKAFPPRSVAQFQAERALYELPGLQ 253
Query: 196 HENILGFIAADNKDNGTWTQ-LWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLA 254
H++I+ FI A G LV E H +GSL YL + +++ALS+A GLA
Sbjct: 254 HDHIVRFITASRGGPGRLLSGPLLVLELHPKGSLCHYLTQYTSDWGSSLRMALSLAQGLA 313
Query: 255 HLHMEI-VGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILN----TIDIPQ 309
LH E Q KP IAHRD+ S+N+L+++ +CAI DLGLA+ + T PQ
Sbjct: 314 FLHEERWQNGQYKPGIAHRDLSSQNVLIREDGSCAIGDLGLALVLPGLTQPPAWTPTQPQ 373
Query: 310 NP----KVGTKRYMAPEMLDDTMNVNIF-ESFKRADIYSVGLVYWEIARRC---SVGGIV 361
P + GT+RYMAPE+LD T+++ + + +RADIYS+ L+ WEI RC
Sbjct: 374 GPAAIMEAGTQRYMAPELLDKTLDLQDWGMALRRADIYSLALLLWEILSRCPDLRPDSSP 433
Query: 362 EEYQLPYYDMVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMG--RIMRECWYANG 419
+QL Y + + P+ +E+ + ++ RP IP+ W+ C A G ++ +CW A+
Sbjct: 434 PPFQLAYEAELGNTPTSDELWALAVQERRRPYIPSTWR-CFATDPDGLRELLEDCWDADP 492
Query: 420 AARLTALRIKKTISQL 435
ARLTA +++ ++ L
Sbjct: 493 EARLTAECVQQRLAAL 508
>gi|187475373 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 89.0 bits (219), Expect = 8e-18
Identities = 75/301 (24%), Positives = 143/301 (47%), Gaps = 50/301 (16%)
Query: 143 RTIVLQEIVGKGRFGEVWHGRWCGEDVAVK-IFSSRDERSWFREAEIYQTVMLRHENILG 201
+ + L + +GKG FG+V G + G VAVK I + +++ EA + LRH N++
Sbjct: 193 KELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVM--TQLRHSNLVQ 250
Query: 202 FIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAG---MIKLALSIASGLAHLHM 258
+ ++ G L++V+EY +GSL DYL +V G ++K +L + + +L
Sbjct: 251 LLGVIVEEKGG---LYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL-- 305
Query: 259 EIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRY 318
+G + HRD+ ++N+LV + ++D GL + S +T +P ++
Sbjct: 306 -----EGNNFV-HRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLP-------VKW 352
Query: 319 MAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSI 378
APE L + + ++D++S G++ WEI G V ++P D+V P +
Sbjct: 353 TAPEALREK------KFSTKSDVWSFGILLWEIYS----FGRVPYPRIPLKDVV---PRV 399
Query: 379 EEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQLCVK 438
E+ K+ P++ +M+ CW+ + A R + L++++ + +
Sbjct: 400 EKGYKMDAPDGCPPAV-------------YEVMKNCWHLDAAMRPSFLQLREQLEHIKTH 446
Query: 439 E 439
E
Sbjct: 447 E 447
>gi|4758078 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 89.0 bits (219), Expect = 8e-18
Identities = 75/301 (24%), Positives = 143/301 (47%), Gaps = 50/301 (16%)
Query: 143 RTIVLQEIVGKGRFGEVWHGRWCGEDVAVK-IFSSRDERSWFREAEIYQTVMLRHENILG 201
+ + L + +GKG FG+V G + G VAVK I + +++ EA + LRH N++
Sbjct: 193 KELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVM--TQLRHSNLVQ 250
Query: 202 FIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAG---MIKLALSIASGLAHLHM 258
+ ++ G L++V+EY +GSL DYL +V G ++K +L + + +L
Sbjct: 251 LLGVIVEEKGG---LYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL-- 305
Query: 259 EIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRY 318
+G + HRD+ ++N+LV + ++D GL + S +T +P ++
Sbjct: 306 -----EGNNFV-HRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLP-------VKW 352
Query: 319 MAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSI 378
APE L + + ++D++S G++ WEI G V ++P D+V P +
Sbjct: 353 TAPEALREK------KFSTKSDVWSFGILLWEIYS----FGRVPYPRIPLKDVV---PRV 399
Query: 379 EEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQLCVK 438
E+ K+ P++ +M+ CW+ + A R + L++++ + +
Sbjct: 400 EKGYKMDAPDGCPPAV-------------YEVMKNCWHLDAAMRPSFLQLREQLEHIKTH 446
Query: 439 E 439
E
Sbjct: 447 E 447
>gi|19526767 MLK-related kinase isoform 2 [Homo sapiens]
Length = 455
Score = 82.0 bits (201), Expect = 1e-15
Identities = 78/281 (27%), Positives = 131/281 (46%), Gaps = 57/281 (20%)
Query: 149 EIVGKGRFGEVWHGRWCGED--VAVKIFSSRDERSWFREAEIYQTVMLRHENILGF--IA 204
E G G FG V+ +W +D VAVK + +EAEI +L H NI+ F +
Sbjct: 20 ENCGGGSFGSVYRAKWISQDKEVAVKKLLKIE-----KEAEILS--VLSHRNIIQFYGVI 72
Query: 205 ADNKDNGTWTQLWLVSEYHEQGSLYDYLNRN---IVTVAGMIKLALSIASGLAHLHMEIV 261
+ + G +V+EY GSLYDY+N N + + ++ A +A G+ +LHME
Sbjct: 73 LEPPNYG------IVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHME-- 124
Query: 262 GTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAP 321
+ HRD+KS+N+++ I D G + H+ + VGT +MAP
Sbjct: 125 ---APVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHM------SLVGTFPWMAP 175
Query: 322 EMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSIEEM 381
E++ ++ + E+ D YS G+V WE+ R ++P+ + ++
Sbjct: 176 EVI---QSLPVSET---CDTYSYGVVLWEMLTR----------EVPFKGLEGL-----QV 214
Query: 382 RKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAAR 422
+V ++ R +IP+ SC R ++ +CW A+ R
Sbjct: 215 AWLVVEKNERLTIPS---SCP--RSFAELLHQCWEADAKKR 250
>gi|82880648 MLK-related kinase isoform 1 [Homo sapiens]
Length = 800
Score = 82.0 bits (201), Expect = 1e-15
Identities = 78/281 (27%), Positives = 131/281 (46%), Gaps = 57/281 (20%)
Query: 149 EIVGKGRFGEVWHGRWCGED--VAVKIFSSRDERSWFREAEIYQTVMLRHENILGF--IA 204
E G G FG V+ +W +D VAVK + +EAEI +L H NI+ F +
Sbjct: 20 ENCGGGSFGSVYRAKWISQDKEVAVKKLLKIE-----KEAEILS--VLSHRNIIQFYGVI 72
Query: 205 ADNKDNGTWTQLWLVSEYHEQGSLYDYLNRN---IVTVAGMIKLALSIASGLAHLHMEIV 261
+ + G +V+EY GSLYDY+N N + + ++ A +A G+ +LHME
Sbjct: 73 LEPPNYG------IVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHME-- 124
Query: 262 GTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAP 321
+ HRD+KS+N+++ I D G + H+ + VGT +MAP
Sbjct: 125 ---APVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHM------SLVGTFPWMAP 175
Query: 322 EMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSIEEM 381
E++ ++ + E+ D YS G+V WE+ R ++P+ + ++
Sbjct: 176 EVI---QSLPVSET---CDTYSYGVVLWEMLTR----------EVPFKGLEGL-----QV 214
Query: 382 RKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAAR 422
+V ++ R +IP+ SC R ++ +CW A+ R
Sbjct: 215 AWLVVEKNERLTIPS---SCP--RSFAELLHQCWEADAKKR 250
>gi|4506401 v-raf-1 murine leukemia viral oncogene homolog 1 [Homo
sapiens]
Length = 648
Score = 80.9 bits (198), Expect = 2e-15
Identities = 71/215 (33%), Positives = 107/215 (49%), Gaps = 24/215 (11%)
Query: 142 ARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLR---HEN 198
A ++L +G G FG V+ G+W G DVAVKI D +A + +LR H N
Sbjct: 346 ASEVMLSTRIGSGSFGTVYKGKWHG-DVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVN 404
Query: 199 ILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLN--RNIVTVAGMIKLALSIASGLAHL 256
IL F+ KDN L +V+++ E SLY +L+ + +I +A A G+ +L
Sbjct: 405 ILLFMGYMTKDN-----LAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYL 459
Query: 257 HMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTK 316
H + I HRD+KS NI + + T I D GLA + + Q G+
Sbjct: 460 HAK--------NIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQ--PTGSV 509
Query: 317 RYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEI 351
+MAPE++ M N SF ++D+YS G+V +E+
Sbjct: 510 LWMAPEVI--RMQDNNPFSF-QSDVYSYGIVLYEL 541
>gi|21735566 mitogen-activated protein kinase kinase kinase 7
isoform D [Homo sapiens]
Length = 491
Score = 80.5 bits (197), Expect = 3e-15
Identities = 64/217 (29%), Positives = 99/217 (45%), Gaps = 30/217 (13%)
Query: 143 RTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGF 202
+ I ++E+VG+G FG V +W +DVA+K S ER F E+ Q + H NI+
Sbjct: 34 KEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAF-IVELRQLSRVNHPNIVKL 92
Query: 203 IAADNKDNGTWTQLWLVSEYHEQGSLYDYLN----RNIVTVAGMIKLALSIASGLAHLHM 258
A + LV EY E GSLY+ L+ T A + L + G+A+LH
Sbjct: 93 YGA------CLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLH- 145
Query: 259 EIVGTQGKPAIAHRDIKSKNILVKKCET-CAIADLGLAVKHDSILNTIDIPQNPKVGTKR 317
+ A+ HRD+K N+L+ T I D G A I G+
Sbjct: 146 ----SMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC-------DIQTHMTNNKGSAA 194
Query: 318 YMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARR 354
+MAPE+ + + ++ D++S G++ WE+ R
Sbjct: 195 WMAPEVFEGS------NYSEKCDVFSWGIILWEVITR 225
>gi|21735564 mitogen-activated protein kinase kinase kinase 7
isoform C [Homo sapiens]
Length = 518
Score = 80.5 bits (197), Expect = 3e-15
Identities = 64/217 (29%), Positives = 99/217 (45%), Gaps = 30/217 (13%)
Query: 143 RTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGF 202
+ I ++E+VG+G FG V +W +DVA+K S ER F E+ Q + H NI+
Sbjct: 34 KEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAF-IVELRQLSRVNHPNIVKL 92
Query: 203 IAADNKDNGTWTQLWLVSEYHEQGSLYDYLN----RNIVTVAGMIKLALSIASGLAHLHM 258
A + LV EY E GSLY+ L+ T A + L + G+A+LH
Sbjct: 93 YGA------CLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLH- 145
Query: 259 EIVGTQGKPAIAHRDIKSKNILVKKCET-CAIADLGLAVKHDSILNTIDIPQNPKVGTKR 317
+ A+ HRD+K N+L+ T I D G A I G+
Sbjct: 146 ----SMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC-------DIQTHMTNNKGSAA 194
Query: 318 YMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARR 354
+MAPE+ + + ++ D++S G++ WE+ R
Sbjct: 195 WMAPEVFEGS------NYSEKCDVFSWGIILWEVITR 225
>gi|21735562 mitogen-activated protein kinase kinase kinase 7
isoform B [Homo sapiens]
Length = 606
Score = 80.5 bits (197), Expect = 3e-15
Identities = 64/217 (29%), Positives = 99/217 (45%), Gaps = 30/217 (13%)
Query: 143 RTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGF 202
+ I ++E+VG+G FG V +W +DVA+K S ER F E+ Q + H NI+
Sbjct: 34 KEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAF-IVELRQLSRVNHPNIVKL 92
Query: 203 IAADNKDNGTWTQLWLVSEYHEQGSLYDYLN----RNIVTVAGMIKLALSIASGLAHLHM 258
A + LV EY E GSLY+ L+ T A + L + G+A+LH
Sbjct: 93 YGA------CLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLH- 145
Query: 259 EIVGTQGKPAIAHRDIKSKNILVKKCET-CAIADLGLAVKHDSILNTIDIPQNPKVGTKR 317
+ A+ HRD+K N+L+ T I D G A I G+
Sbjct: 146 ----SMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC-------DIQTHMTNNKGSAA 194
Query: 318 YMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARR 354
+MAPE+ + + ++ D++S G++ WE+ R
Sbjct: 195 WMAPEVFEGS------NYSEKCDVFSWGIILWEVITR 225
>gi|4507361 mitogen-activated protein kinase kinase kinase 7 isoform
A [Homo sapiens]
Length = 579
Score = 80.5 bits (197), Expect = 3e-15
Identities = 64/217 (29%), Positives = 99/217 (45%), Gaps = 30/217 (13%)
Query: 143 RTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGF 202
+ I ++E+VG+G FG V +W +DVA+K S ER F E+ Q + H NI+
Sbjct: 34 KEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAF-IVELRQLSRVNHPNIVKL 92
Query: 203 IAADNKDNGTWTQLWLVSEYHEQGSLYDYLN----RNIVTVAGMIKLALSIASGLAHLHM 258
A + LV EY E GSLY+ L+ T A + L + G+A+LH
Sbjct: 93 YGA------CLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLH- 145
Query: 259 EIVGTQGKPAIAHRDIKSKNILVKKCET-CAIADLGLAVKHDSILNTIDIPQNPKVGTKR 317
+ A+ HRD+K N+L+ T I D G A I G+
Sbjct: 146 ----SMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC-------DIQTHMTNNKGSAA 194
Query: 318 YMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARR 354
+MAPE+ + + ++ D++S G++ WE+ R
Sbjct: 195 WMAPEVFEGS------NYSEKCDVFSWGIILWEVITR 225
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.135 0.418
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,968,472
Number of Sequences: 37866
Number of extensions: 737193
Number of successful extensions: 2816
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 192
Number of HSP's successfully gapped in prelim test: 486
Number of HSP's that attempted gapping in prelim test: 1917
Number of HSP's gapped (non-prelim): 741
length of query: 443
length of database: 18,247,518
effective HSP length: 105
effective length of query: 338
effective length of database: 14,271,588
effective search space: 4823796744
effective search space used: 4823796744
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.