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Search of human proteins with 161333833
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|161333833 activin A receptor, type IC isoform 1 [Homo
sapiens]
(493 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|161333833 activin A receptor, type IC isoform 1 [Homo sapiens] 1006 0.0
gi|161333835 activin A receptor, type IC isoform 2 [Homo sapiens] 905 0.0
gi|4759226 transforming growth factor, beta receptor I isoform 1... 659 0.0
gi|4757720 activin A receptor, type IB isoform a precursor [Homo... 645 0.0
gi|161333837 activin A receptor, type IC isoform 3 [Homo sapiens] 639 0.0
gi|33598910 activin A receptor, type IB isoform b precursor [Hom... 577 e-164
gi|195963412 transforming growth factor, beta receptor I isoform... 537 e-152
gi|33598912 activin A receptor, type IB isoform c precursor [Hom... 499 e-141
gi|161333839 activin A receptor, type IC isoform 4 [Homo sapiens] 482 e-136
gi|41349437 bone morphogenetic protein receptor, type IA precurs... 459 e-129
gi|4502431 bone morphogenetic protein receptor, type IB precurso... 457 e-128
gi|166235898 activin A receptor, type I precursor [Homo sapiens] 452 e-127
gi|4501895 activin A receptor, type I precursor [Homo sapiens] 452 e-127
gi|116734714 activin A receptor type II-like 1 [Homo sapiens] 417 e-116
gi|116734712 activin A receptor type II-like 1 [Homo sapiens] 417 e-116
gi|4501897 activin A receptor, type IIA precursor [Homo sapiens] 238 9e-63
gi|116734708 activin A receptor, type IIB precursor [Homo sapiens] 237 2e-62
gi|67782324 transforming growth factor, beta receptor II isoform... 227 2e-59
gi|67782326 transforming growth factor, beta receptor II isoform... 227 2e-59
gi|15451916 bone morphogenetic protein receptor type II precurso... 197 2e-50
gi|10198656 anti-Mullerian hormone receptor, type II [Homo sapiens] 170 3e-42
gi|187475373 c-src tyrosine kinase [Homo sapiens] 89 9e-18
gi|4758078 c-src tyrosine kinase [Homo sapiens] 89 9e-18
gi|19526767 MLK-related kinase isoform 2 [Homo sapiens] 82 1e-15
gi|82880648 MLK-related kinase isoform 1 [Homo sapiens] 82 1e-15
gi|4506401 v-raf-1 murine leukemia viral oncogene homolog 1 [Hom... 81 2e-15
gi|21735566 mitogen-activated protein kinase kinase kinase 7 iso... 80 3e-15
gi|21735564 mitogen-activated protein kinase kinase kinase 7 iso... 80 3e-15
gi|21735562 mitogen-activated protein kinase kinase kinase 7 iso... 80 3e-15
gi|4507361 mitogen-activated protein kinase kinase kinase 7 isof... 80 3e-15
>gi|161333833 activin A receptor, type IC isoform 1 [Homo sapiens]
Length = 493
Score = 1006 bits (2601), Expect = 0.0
Identities = 493/493 (100%), Positives = 493/493 (100%)
Query: 1 MTRALCSALRQALLLLAAAAELSPGLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVI 60
MTRALCSALRQALLLLAAAAELSPGLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVI
Sbjct: 1 MTRALCSALRQALLLLAAAAELSPGLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVI 60
Query: 61 KSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPTASPNAPKLGPMELAIIITV 120
KSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPTASPNAPKLGPMELAIIITV
Sbjct: 61 KSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPTASPNAPKLGPMELAIIITV 120
Query: 121 PVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKTLKDLIYDVTASGSG 180
PVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKTLKDLIYDVTASGSG
Sbjct: 121 PVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKTLKDLIYDVTASGSG 180
Query: 181 SGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQ 240
SGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQ
Sbjct: 181 SGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQ 240
Query: 241 TVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIA 300
TVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIA
Sbjct: 241 TVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIA 300
Query: 301 SGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQN 360
SGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQN
Sbjct: 301 SGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQN 360
Query: 361 PKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYD 420
PKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYD
Sbjct: 361 PKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYD 420
Query: 421 MVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKK 480
MVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKK
Sbjct: 421 MVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKK 480
Query: 481 TISQLCVKEDCKA 493
TISQLCVKEDCKA
Sbjct: 481 TISQLCVKEDCKA 493
>gi|161333835 activin A receptor, type IC isoform 2 [Homo sapiens]
Length = 443
Score = 905 bits (2340), Expect = 0.0
Identities = 443/443 (100%), Positives = 443/443 (100%)
Query: 51 MLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPTASPNAPKLG 110
MLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPTASPNAPKLG
Sbjct: 1 MLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPTASPNAPKLG 60
Query: 111 PMELAIIITVPVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKTLKDL 170
PMELAIIITVPVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKTLKDL
Sbjct: 61 PMELAIIITVPVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKTLKDL 120
Query: 171 IYDVTASGSGSGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDER 230
IYDVTASGSGSGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDER
Sbjct: 121 IYDVTASGSGSGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDER 180
Query: 231 SWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVA 290
SWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVA
Sbjct: 181 SWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVA 240
Query: 291 GMIKLALSIASGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDS 350
GMIKLALSIASGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDS
Sbjct: 241 GMIKLALSIASGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDS 300
Query: 351 ILNTIDIPQNPKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGI 410
ILNTIDIPQNPKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGI
Sbjct: 301 ILNTIDIPQNPKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGI 360
Query: 411 VEEYQLPYYDMVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGA 470
VEEYQLPYYDMVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGA
Sbjct: 361 VEEYQLPYYDMVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGA 420
Query: 471 ARLTALRIKKTISQLCVKEDCKA 493
ARLTALRIKKTISQLCVKEDCKA
Sbjct: 421 ARLTALRIKKTISQLCVKEDCKA 443
>gi|4759226 transforming growth factor, beta receptor I isoform 1
precursor [Homo sapiens]
Length = 503
Score = 659 bits (1700), Expect = 0.0
Identities = 342/504 (67%), Positives = 391/504 (77%), Gaps = 19/504 (3%)
Query: 4 ALCSALRQALLLL------AAAAELSPG---LKCVCLLCDSSNFTCQTEGACWASVMLTN 54
A +A R LLLL AAAA L PG L+C C LC NFTC T+G C+ SV T
Sbjct: 3 AAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETT 62
Query: 55 GKEQVIKSCVS----LPELNAQVFCHSS--NNVTKTECCFTDFCNNITLHLPTASPNAPK 108
K C++ +P V SS +VT T CC D CN I LPT ++P
Sbjct: 63 DKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKI--ELPTTVKSSPG 120
Query: 109 LGPMELAIIITVPVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKTLK 168
LGP+ELA +I PVC + I+ ML V+ C R + + PN E+P + ++ G TLK
Sbjct: 121 LGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRV--PNEEDPSLDRPFISEGTTLK 178
Query: 169 DLIYDVTASGSGSGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRD 228
DLIYD+T SGSGSGLPLLVQRTIARTIVLQE +GKGRFGEVW G+W GE+VAVKIFSSR+
Sbjct: 179 DLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSRE 238
Query: 229 ERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVT 288
ERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVS+YHE GSL+DYLNR VT
Sbjct: 239 ERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVT 298
Query: 289 VAGMIKLALSIASGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKH 348
V GMIKLALS ASGLAHLHMEIVGTQGKPAIAHRD+KSKNILVKK TC IADLGLAV+H
Sbjct: 299 VEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRH 358
Query: 349 DSILNTIDIPQNPKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVG 408
DS +TIDI N +VGTKRYMAPE+LDD++N+ FESFKRADIY++GLV+WEIARRCS+G
Sbjct: 359 DSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIG 418
Query: 409 GIVEEYQLPYYDMVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYAN 468
GI E+YQLPYYD+VPSDPS+EEMRKVVC+QK RP+IPN+WQSCEALRVM +IMRECWYAN
Sbjct: 419 GIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYAN 478
Query: 469 GAARLTALRIKKTISQLCVKEDCK 492
GAARLTALRIKKT+SQL +E K
Sbjct: 479 GAARLTALRIKKTLSQLSQQEGIK 502
>gi|4757720 activin A receptor, type IB isoform a precursor [Homo
sapiens]
Length = 505
Score = 645 bits (1663), Expect = 0.0
Identities = 323/491 (65%), Positives = 384/491 (78%), Gaps = 12/491 (2%)
Query: 13 LLLLAAAAELSP----GLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVIKSCVSLPE 68
+LLLA + P L C C C +N+TC+T+GAC S+ +G E +++C+ E
Sbjct: 15 VLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLDGMEHHVRTCIPKVE 74
Query: 69 L---NAQVFCHSSNNVTKTECCFTDFCNNITLHLPTA---SPNAPKL-GPMELAIIITVP 121
L +C SS ++ T CC+TD+CN I L +P+ P P + GP+EL II P
Sbjct: 75 LVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPSMWGPVELVGIIAGP 134
Query: 122 VCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKTLKDLIYDVTASGSGS 181
V LL + ++ Q Y ++R ++E+P E L + KTL+DL+YD++ SGSGS
Sbjct: 135 VFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCL-SKDKTLQDLVYDLSTSGSGS 193
Query: 182 GLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQT 241
GLPL VQRT+ARTIVLQEI+GKGRFGEVW GRW G DVAVKIFSSR+ERSWFREAEIYQT
Sbjct: 194 GLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQT 253
Query: 242 VMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIAS 301
VMLRHENILGFIAADNKDNGTWTQLWLVS+YHE GSL+DYLNR VT+ GMIKLALS AS
Sbjct: 254 VMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAAS 313
Query: 302 GLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNP 361
GLAHLHMEIVGTQGKP IAHRD+KSKNILVKK CAIADLGLAV+HD++ +TIDI N
Sbjct: 314 GLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQ 373
Query: 362 KVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDM 421
+VGTKRYMAPE+LD+T+N+ F+SFK ADIY++GLVYWEIARRC+ GG+ EEYQLPYYD+
Sbjct: 374 RVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYDL 433
Query: 422 VPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKT 481
VPSDPSIEEMRKVVCDQK RP+IPN WQS EALRVMG++MRECWYANGAARLTALRIKKT
Sbjct: 434 VPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKT 493
Query: 482 ISQLCVKEDCK 492
+SQL V+ED K
Sbjct: 494 LSQLSVQEDVK 504
>gi|161333837 activin A receptor, type IC isoform 3 [Homo sapiens]
Length = 413
Score = 639 bits (1647), Expect = 0.0
Identities = 312/313 (99%), Positives = 313/313 (100%)
Query: 181 SGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQ 240
+GLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQ
Sbjct: 101 TGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQ 160
Query: 241 TVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIA 300
TVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIA
Sbjct: 161 TVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIA 220
Query: 301 SGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQN 360
SGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQN
Sbjct: 221 SGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQN 280
Query: 361 PKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYD 420
PKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYD
Sbjct: 281 PKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYD 340
Query: 421 MVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKK 480
MVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKK
Sbjct: 341 MVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKK 400
Query: 481 TISQLCVKEDCKA 493
TISQLCVKEDCKA
Sbjct: 401 TISQLCVKEDCKA 413
Score = 214 bits (546), Expect = 1e-55
Identities = 102/104 (98%), Positives = 102/104 (98%)
Query: 1 MTRALCSALRQALLLLAAAAELSPGLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVI 60
MTRALCSALRQALLLLAAAAELSPGLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVI
Sbjct: 1 MTRALCSALRQALLLLAAAAELSPGLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVI 60
Query: 61 KSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPTASP 104
KSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPT P
Sbjct: 61 KSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPTGLP 104
>gi|33598910 activin A receptor, type IB isoform b precursor [Homo
sapiens]
Length = 476
Score = 577 bits (1486), Expect = e-164
Identities = 289/451 (64%), Positives = 346/451 (76%), Gaps = 12/451 (2%)
Query: 13 LLLLAAAAELSP----GLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVIKSCVSLPE 68
+LLLA + P L C C C +N+TC+T+GAC S+ +G E +++C+ E
Sbjct: 15 VLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLDGMEHHVRTCIPKVE 74
Query: 69 L---NAQVFCHSSNNVTKTECCFTDFCNNITLHLPTA---SPNAPKL-GPMELAIIITVP 121
L +C SS ++ T CC+TD+CN I L +P+ P P + GP+EL II P
Sbjct: 75 LVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPSMWGPVELVGIIAGP 134
Query: 122 VCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKTLKDLIYDVTASGSGS 181
V LL + ++ Q Y ++R ++E+P E L + KTL+DL+YD++ SGSGS
Sbjct: 135 VFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCL-SKDKTLQDLVYDLSTSGSGS 193
Query: 182 GLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQT 241
GLPL VQRT+ARTIVLQEI+GKGRFGEVW GRW G DVAVKIFSSR+ERSWFREAEIYQT
Sbjct: 194 GLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQT 253
Query: 242 VMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIAS 301
VMLRHENILGFIAADNKDNGTWTQLWLVS+YHE GSL+DYLNR VT+ GMIKLALS AS
Sbjct: 254 VMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAAS 313
Query: 302 GLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNP 361
GLAHLHMEIVGTQGKP IAHRD+KSKNILVKK CAIADLGLAV+HD++ +TIDI N
Sbjct: 314 GLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQ 373
Query: 362 KVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDM 421
+VGTKRYMAPE+LD+T+N+ F+SFK ADIY++GLVYWEIARRC+ GG+ EEYQLPYYD+
Sbjct: 374 RVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYDL 433
Query: 422 VPSDPSIEEMRKVVCDQKFRPSIPNQWQSCE 452
VPSDPSIEEMRKVVCDQK RP+IPN WQS E
Sbjct: 434 VPSDPSIEEMRKVVCDQKLRPNIPNWWQSYE 464
>gi|195963412 transforming growth factor, beta receptor I isoform 2
precursor [Homo sapiens]
Length = 426
Score = 537 bits (1383), Expect = e-152
Identities = 259/312 (83%), Positives = 287/312 (91%)
Query: 181 SGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQ 240
+GLPLLVQRTIARTIVLQE +GKGRFGEVW G+W GE+VAVKIFSSR+ERSWFREAEIYQ
Sbjct: 114 TGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQ 173
Query: 241 TVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIA 300
TVMLRHENILGFIAADNKDNGTWTQLWLVS+YHE GSL+DYLNR VTV GMIKLALS A
Sbjct: 174 TVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTA 233
Query: 301 SGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQN 360
SGLAHLHMEIVGTQGKPAIAHRD+KSKNILVKK TC IADLGLAV+HDS +TIDI N
Sbjct: 234 SGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPN 293
Query: 361 PKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYD 420
+VGTKRYMAPE+LDD++N+ FESFKRADIY++GLV+WEIARRCS+GGI E+YQLPYYD
Sbjct: 294 HRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYD 353
Query: 421 MVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKK 480
+VPSDPS+EEMRKVVC+QK RP+IPN+WQSCEALRVM +IMRECWYANGAARLTALRIKK
Sbjct: 354 LVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKK 413
Query: 481 TISQLCVKEDCK 492
T+SQL +E K
Sbjct: 414 TLSQLSQQEGIK 425
Score = 61.2 bits (147), Expect = 2e-09
Identities = 45/109 (41%), Positives = 53/109 (48%), Gaps = 15/109 (13%)
Query: 4 ALCSALRQALLLL------AAAAELSPG---LKCVCLLCDSSNFTCQTEGACWASVMLTN 54
A +A R LLLL AAAA L PG L+C C LC NFTC T+G C+ SV T
Sbjct: 3 AAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETT 62
Query: 55 GKEQVIKSCVS----LPELNAQVFCHSS--NNVTKTECCFTDFCNNITL 97
K C++ +P V SS +VT T CC D CN I L
Sbjct: 63 DKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIEL 111
>gi|33598912 activin A receptor, type IB isoform c precursor [Homo
sapiens]
Length = 487
Score = 499 bits (1286), Expect = e-141
Identities = 253/408 (62%), Positives = 307/408 (75%), Gaps = 12/408 (2%)
Query: 13 LLLLAAAAELSP----GLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVIKSCVSLPE 68
+LLLA + P L C C C +N+TC+T+GAC S+ +G E +++C+ E
Sbjct: 15 VLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLDGMEHHVRTCIPKVE 74
Query: 69 L---NAQVFCHSSNNVTKTECCFTDFCNNITLHLPTA---SPNAPKL-GPMELAIIITVP 121
L +C SS ++ T CC+TD+CN I L +P+ P P + GP+EL II P
Sbjct: 75 LVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPSMWGPVELVGIIAGP 134
Query: 122 VCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKTLKDLIYDVTASGSGS 181
V LL + ++ Q Y ++R ++E+P E L + KTL+DL+YD++ SGSGS
Sbjct: 135 VFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCL-SKDKTLQDLVYDLSTSGSGS 193
Query: 182 GLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQT 241
GLPL VQRT+ARTIVLQEI+GKGRFGEVW GRW G DVAVKIFSSR+ERSWFREAEIYQT
Sbjct: 194 GLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQT 253
Query: 242 VMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIAS 301
VMLRHENILGFIAADNKDNGTWTQLWLVS+YHE GSL+DYLNR VT+ GMIKLALS AS
Sbjct: 254 VMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAAS 313
Query: 302 GLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNP 361
GLAHLHMEIVGTQGKP IAHRD+KSKNILVKK CAIADLGLAV+HD++ +TIDI N
Sbjct: 314 GLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQ 373
Query: 362 KVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGG 409
+VGTKRYMAPE+LD+T+N+ F+SFK ADIY++GLVYWEIARRC+ GG
Sbjct: 374 RVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSGG 421
>gi|161333839 activin A receptor, type IC isoform 4 [Homo sapiens]
Length = 336
Score = 482 bits (1241), Expect = e-136
Identities = 235/235 (100%), Positives = 235/235 (100%)
Query: 259 DNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQGKPA 318
DNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQGKPA
Sbjct: 102 DNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQGKPA 161
Query: 319 IAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDDTM 378
IAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDDTM
Sbjct: 162 IAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDDTM 221
Query: 379 NVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQ 438
NVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQ
Sbjct: 222 NVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQ 281
Query: 439 KFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQLCVKEDCKA 493
KFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQLCVKEDCKA
Sbjct: 282 KFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQLCVKEDCKA 336
Score = 213 bits (541), Expect = 4e-55
Identities = 101/101 (100%), Positives = 101/101 (100%)
Query: 1 MTRALCSALRQALLLLAAAAELSPGLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVI 60
MTRALCSALRQALLLLAAAAELSPGLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVI
Sbjct: 1 MTRALCSALRQALLLLAAAAELSPGLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVI 60
Query: 61 KSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPT 101
KSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPT
Sbjct: 61 KSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPT 101
>gi|41349437 bone morphogenetic protein receptor, type IA precursor
[Homo sapiens]
Length = 532
Score = 459 bits (1181), Expect = e-129
Identities = 248/487 (50%), Positives = 326/487 (66%), Gaps = 18/487 (3%)
Query: 18 AAAELSPGLKCVCL-LC--DSSNFTCQTEGACWASVMLTNGKEQVIKS-CVSLPELNAQV 73
A + P LKC C C D+ N TC T G C+A + + E + S C+ + Q
Sbjct: 51 APEDTLPFLKCYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQC 110
Query: 74 FCHSSNNVTKT-ECCFTDFCNNITLHLPTASPNAPKLGPME------LAIIITVPVCLLS 126
+ +T ECC T+ CN PT P +GP L ++I++ VC+++
Sbjct: 111 KDSPKAQLRRTIECCRTNLCNQYLQ--PTLPPVV--IGPFFDGSIRWLVLLISMAVCIIA 166
Query: 127 IAAMLTVWACQGRQC-SYRKKKRPNVEEPLSECNLVNAGKTLKDLIYDVTASGSGSGLPL 185
+ + + C C S ++R N + E + G++LKDLI +SGSGSGLPL
Sbjct: 167 MIIFSSCF-CYKHYCKSISSRRRYNRDLEQDEA-FIPVGESLKDLIDQSQSSGSGSGLPL 224
Query: 186 LVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLR 245
LVQRTIA+ I + VGKGR+GEVW G+W GE VAVK+F + +E SWFRE EIYQTV++R
Sbjct: 225 LVQRTIAKQIQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMR 284
Query: 246 HENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAH 305
HENILGFIAAD K G+WTQL+L+++YHE GSLYD+L + ++KLA S A GL H
Sbjct: 285 HENILGFIAADIKGTGSWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCH 344
Query: 306 LHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGT 365
LH EI GTQGKPAIAHRD+KSKNIL+KK +C IADLGLAVK +S N +D+P N +VGT
Sbjct: 345 LHTEIYGTQGKPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGT 404
Query: 366 KRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSD 425
KRYMAPE+LD+++N N F+ + ADIYS GL+ WE+ARRC GGIVEEYQLPYY+MVPSD
Sbjct: 405 KRYMAPEVLDESLNKNHFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSD 464
Query: 426 PSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQL 485
PS E+MR+VVC ++ RP + N+W S E LR + ++M ECW N A+RLTALRIKKT++++
Sbjct: 465 PSYEDMREVVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTLAKM 524
Query: 486 CVKEDCK 492
+D K
Sbjct: 525 VESQDVK 531
>gi|4502431 bone morphogenetic protein receptor, type IB precursor
[Homo sapiens]
Length = 502
Score = 457 bits (1176), Expect = e-128
Identities = 247/468 (52%), Positives = 318/468 (67%), Gaps = 16/468 (3%)
Query: 34 DSSNFTCQTEGACWASVMLTNGKEQVIKS-CVSLPELNAQVFCHSS---NNVTKTECCFT 89
DS N C T+G C+ + + V+ S C+ L + Q C + + ECC
Sbjct: 41 DSVNNICSTDGYCFTMIEEDDSGLPVVTSGCLGLEGSDFQ--CRDTPIPHQRRSIECCTE 98
Query: 90 DFCNNITLHLPTASPNAPKL---GPME-LAIIITVPVCLLSIAAMLTVWACQGRQCSYRK 145
N LH PT P + GP+ A++I+V VC S+ +L + C R R+
Sbjct: 99 RNECNKDLH-PTLPPLKNRDFVDGPIHHRALLISVTVC--SLLLVLIILFCYFRY--KRQ 153
Query: 146 KKRPNVEEPLSECNL-VNAGKTLKDLIYDVTASGSGSGLPLLVQRTIARTIVLQEIVGKG 204
+ RP L + + G++L+DLI +SGSGSGLPLLVQRTIA+ I + + +GKG
Sbjct: 154 ETRPRYSIGLEQDETYIPPGESLRDLIEQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKG 213
Query: 205 RFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWT 264
R+GEVW G+W GE VAVK+F + +E SWFRE EIYQTV++RHENILGFIAAD K G+WT
Sbjct: 214 RYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWT 273
Query: 265 QLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQGKPAIAHRDI 324
QL+L+++YHE GSLYDYL + M+KLA S SGL HLH EI TQGKPAIAHRD+
Sbjct: 274 QLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDL 333
Query: 325 KSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDDTMNVNIFE 384
KSKNILVKK TC IADLGLAVK S N +DIP N +VGTKRYM PE+LD+++N N F+
Sbjct: 334 KSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQ 393
Query: 385 SFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQKFRPSI 444
S+ AD+YS GL+ WE+ARRC GGIVEEYQLPY+D+VPSDPS E+MR++VC +K RPS
Sbjct: 394 SYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSF 453
Query: 445 PNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQLCVKEDCK 492
PN+W S E LR MG++M ECW N A+RLTALR+KKT++++ +D K
Sbjct: 454 PNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTLAKMSESQDIK 501
>gi|166235898 activin A receptor, type I precursor [Homo sapiens]
Length = 509
Score = 452 bits (1163), Expect = e-127
Identities = 239/477 (50%), Positives = 312/477 (65%), Gaps = 15/477 (3%)
Query: 28 CVC--LLCDSSNFTCQTEGACWASVMLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTE 85
CVC L C + + C+ + C++S+ + +G K C + E + E
Sbjct: 35 CVCEGLSCGNEDH-CEGQ-QCFSSLSINDGFHVYQKGCFQVYEQGKMTCKTPPSPGQAVE 92
Query: 86 CCFTDFCN-NITLHLPTASPNAPKLGPMELAIIITVPVCLLSIAAMLTVWACQGRQCSYR 144
CC D+CN NIT LPT + P L + + + + ++ + + R+ R
Sbjct: 93 CCQGDWCNRNITAQLPTKGKSFPGTQNFHLEVGLIILSVVFAVCLLACLLGVALRKFKRR 152
Query: 145 KKKRPNVEE----PLSECNLVNAG-KTLKDLIYDVTASGSGSGLPLLVQRTIARTIVLQE 199
++R N + + N G TL DL+ SGSGSGLP LVQRT+AR I L E
Sbjct: 153 NQERLNPRDVEYGTIEGLITTNVGDSTLADLLDHSCTSGSGSGLPFLVQRTVARQITLLE 212
Query: 200 IVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADNKD 259
VGKGR+GEVW G W GE+VAVKIFSSRDE+SWFRE E+Y TVMLRHENILGFIA+D
Sbjct: 213 CVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTS 272
Query: 260 NGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQGKPAI 319
+ TQLWL++ YHE GSLYDYL + +++ LSIASGLAHLH+EI GTQGKPAI
Sbjct: 273 RHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAI 332
Query: 320 AHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDDTMN 379
AHRD+KSKNILVKK C IADLGLAV H N +D+ NP+VGTKRYMAPE+LD+T+
Sbjct: 333 AHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQ 392
Query: 380 VNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQK 439
V+ F+S+KR DI++ GLV WE+ARR GIVE+Y+ P+YD+VP+DPS E+MRKVVC +
Sbjct: 393 VDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQ 452
Query: 440 FRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQL-----CVKEDC 491
RP+IPN+W S L + ++M+ECWY N +ARLTALRIKKT++++ +K DC
Sbjct: 453 QRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNSLDKLKTDC 509
>gi|4501895 activin A receptor, type I precursor [Homo sapiens]
Length = 509
Score = 452 bits (1163), Expect = e-127
Identities = 239/477 (50%), Positives = 312/477 (65%), Gaps = 15/477 (3%)
Query: 28 CVC--LLCDSSNFTCQTEGACWASVMLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTE 85
CVC L C + + C+ + C++S+ + +G K C + E + E
Sbjct: 35 CVCEGLSCGNEDH-CEGQ-QCFSSLSINDGFHVYQKGCFQVYEQGKMTCKTPPSPGQAVE 92
Query: 86 CCFTDFCN-NITLHLPTASPNAPKLGPMELAIIITVPVCLLSIAAMLTVWACQGRQCSYR 144
CC D+CN NIT LPT + P L + + + + ++ + + R+ R
Sbjct: 93 CCQGDWCNRNITAQLPTKGKSFPGTQNFHLEVGLIILSVVFAVCLLACLLGVALRKFKRR 152
Query: 145 KKKRPNVEE----PLSECNLVNAG-KTLKDLIYDVTASGSGSGLPLLVQRTIARTIVLQE 199
++R N + + N G TL DL+ SGSGSGLP LVQRT+AR I L E
Sbjct: 153 NQERLNPRDVEYGTIEGLITTNVGDSTLADLLDHSCTSGSGSGLPFLVQRTVARQITLLE 212
Query: 200 IVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADNKD 259
VGKGR+GEVW G W GE+VAVKIFSSRDE+SWFRE E+Y TVMLRHENILGFIA+D
Sbjct: 213 CVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTS 272
Query: 260 NGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQGKPAI 319
+ TQLWL++ YHE GSLYDYL + +++ LSIASGLAHLH+EI GTQGKPAI
Sbjct: 273 RHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAI 332
Query: 320 AHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDDTMN 379
AHRD+KSKNILVKK C IADLGLAV H N +D+ NP+VGTKRYMAPE+LD+T+
Sbjct: 333 AHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQ 392
Query: 380 VNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQK 439
V+ F+S+KR DI++ GLV WE+ARR GIVE+Y+ P+YD+VP+DPS E+MRKVVC +
Sbjct: 393 VDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQ 452
Query: 440 FRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQL-----CVKEDC 491
RP+IPN+W S L + ++M+ECWY N +ARLTALRIKKT++++ +K DC
Sbjct: 453 QRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNSLDKLKTDC 509
>gi|116734714 activin A receptor type II-like 1 [Homo sapiens]
Length = 503
Score = 417 bits (1071), Expect = e-116
Identities = 224/466 (48%), Positives = 301/466 (64%), Gaps = 14/466 (3%)
Query: 29 VCLLCDSSNFTCQTEGACWASVMLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTECCF 88
V C+S + T W +V+L + + + L+ ++ CC
Sbjct: 32 VTCTCESPHCKGPTCRGAWCTVVLVREEGRHPQEHRGCGNLHRELCRGRPTEFVNHYCCD 91
Query: 89 TDFCN-NITLHLPTASPNAPKLGPM-ELAIIITVPVCLLSIAAM--LTVWACQGRQCSYR 144
+ CN N++L L P + + G +LA+I+ + LL++ A+ L +W + RQ
Sbjct: 92 SHLCNHNVSLVLEATQPPSEQPGTDGQLALILGPVLALLALVALGVLGLWHVRRRQ---- 147
Query: 145 KKKRPNVEEPLSECNLV-----NAGKTLKDLIYDVTASGSGSGLPLLVQRTIARTIVLQE 199
+K+ + L E +L+ L DL+ +GSGSGLP LVQRT+AR + L E
Sbjct: 148 -EKQRGLHSELGESSLILKASEQGDSMLGDLLDSDCTTGSGSGLPFLVQRTVARQVALVE 206
Query: 200 IVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADNKD 259
VGKGR+GEVW G W GE VAVKIFSSRDE+SWFRE EIY TV+LRH+NILGFIA+D
Sbjct: 207 CVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTS 266
Query: 260 NGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQGKPAI 319
+ TQLWL++ YHE GSLYD+L R + ++LA+S A GLAHLH+EI GTQGKPAI
Sbjct: 267 RNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFGTQGKPAI 326
Query: 320 AHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDDTMN 379
AHRD KS+N+LVK C IADLGLAV H + +DI NP+VGTKRYMAPE+LD+ +
Sbjct: 327 AHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLDEQIR 386
Query: 380 VNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQK 439
+ FES+K DI++ GLV WEIARR V GIVE+Y+ P+YD+VP+DPS E+M+KVVC +
Sbjct: 387 TDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVCVDQ 446
Query: 440 FRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQL 485
P+IPN+ + L + ++MRECWY N +ARLTALRIKKT+ ++
Sbjct: 447 QTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKI 492
>gi|116734712 activin A receptor type II-like 1 [Homo sapiens]
Length = 503
Score = 417 bits (1071), Expect = e-116
Identities = 224/466 (48%), Positives = 301/466 (64%), Gaps = 14/466 (3%)
Query: 29 VCLLCDSSNFTCQTEGACWASVMLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTECCF 88
V C+S + T W +V+L + + + L+ ++ CC
Sbjct: 32 VTCTCESPHCKGPTCRGAWCTVVLVREEGRHPQEHRGCGNLHRELCRGRPTEFVNHYCCD 91
Query: 89 TDFCN-NITLHLPTASPNAPKLGPM-ELAIIITVPVCLLSIAAM--LTVWACQGRQCSYR 144
+ CN N++L L P + + G +LA+I+ + LL++ A+ L +W + RQ
Sbjct: 92 SHLCNHNVSLVLEATQPPSEQPGTDGQLALILGPVLALLALVALGVLGLWHVRRRQ---- 147
Query: 145 KKKRPNVEEPLSECNLV-----NAGKTLKDLIYDVTASGSGSGLPLLVQRTIARTIVLQE 199
+K+ + L E +L+ L DL+ +GSGSGLP LVQRT+AR + L E
Sbjct: 148 -EKQRGLHSELGESSLILKASEQGDSMLGDLLDSDCTTGSGSGLPFLVQRTVARQVALVE 206
Query: 200 IVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADNKD 259
VGKGR+GEVW G W GE VAVKIFSSRDE+SWFRE EIY TV+LRH+NILGFIA+D
Sbjct: 207 CVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTS 266
Query: 260 NGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQGKPAI 319
+ TQLWL++ YHE GSLYD+L R + ++LA+S A GLAHLH+EI GTQGKPAI
Sbjct: 267 RNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFGTQGKPAI 326
Query: 320 AHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDDTMN 379
AHRD KS+N+LVK C IADLGLAV H + +DI NP+VGTKRYMAPE+LD+ +
Sbjct: 327 AHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLDEQIR 386
Query: 380 VNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQK 439
+ FES+K DI++ GLV WEIARR V GIVE+Y+ P+YD+VP+DPS E+M+KVVC +
Sbjct: 387 TDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVCVDQ 446
Query: 440 FRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQL 485
P+IPN+ + L + ++MRECWY N +ARLTALRIKKT+ ++
Sbjct: 447 QTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKI 492
>gi|4501897 activin A receptor, type IIA precursor [Homo sapiens]
Length = 513
Score = 238 bits (607), Expect = 9e-63
Identities = 150/458 (32%), Positives = 245/458 (53%), Gaps = 53/458 (11%)
Query: 46 CWASVMLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTE--------CCFTDFCNN--- 94
C+A+ +G +++K L ++N C+ + + + CC + CN
Sbjct: 60 CFATWKNISGSIEIVKQGCWLDDIN----CYDRTDCVEKKDSPEVYFCCCEGNMCNEKFS 115
Query: 95 ----ITLHLPTASPNAPKLGPMELAIIITVPVCLLSIAAMLTVWACQGRQCSYRKKKRPN 150
+ + PT++P PK + + VP+ L++ + W + + +Y P
Sbjct: 116 YFPEMEVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHKMAY-----PP 170
Query: 151 VEEPLSECNLVNAGKTLKDLIYDVTASGSGSGLPLLVQRTIARTIVLQEIVGKGRFGEVW 210
V P + G PLL + + L E+ +GRFG VW
Sbjct: 171 VLVPTQD-------------------PGPPPPSPLLGLKPLQ----LLEVKARGRFGCVW 207
Query: 211 HGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVS 270
+ E VAVKIF +D++SW E E+Y ++HENIL FI A+ + LWL++
Sbjct: 208 KAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGTSVDVDLWLIT 267
Query: 271 EYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQG--KPAIAHRDIKSKN 328
+HE+GSL D+L N+V+ + +A ++A GLA+LH +I G + KPAI+HRDIKSKN
Sbjct: 268 AFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKN 327
Query: 329 ILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDDTMNVNIFESFKR 388
+L+K T IAD GLA+K ++ + D + +VGT+RYMAPE+L+ +N ++F R
Sbjct: 328 VLLKNNLTACIADFGLALKFEAGKSAGD--THGQVGTRRYMAPEVLEGAINFQ-RDAFLR 384
Query: 389 ADIYSVGLVYWEIARRCSVG-GIVEEYQLPYYDMVPSDPSIEEMRKVVCDQKFRPSIPNQ 447
D+Y++GLV WE+A RC+ G V+EY LP+ + + PS+E+M++VV +K RP + +
Sbjct: 385 IDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDY 444
Query: 448 WQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQL 485
WQ + ++ + ECW + ARL+A + + I+Q+
Sbjct: 445 WQKHAGMAMLCETIEECWDHDAEARLSAGCVGERITQM 482
>gi|116734708 activin A receptor, type IIB precursor [Homo sapiens]
Length = 512
Score = 237 bits (605), Expect = 2e-62
Identities = 153/459 (33%), Positives = 240/459 (52%), Gaps = 59/459 (12%)
Query: 46 CWASVMLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTE--------CCFTDFCNNITL 97
C+AS ++G +++K L + N C+ TE CC +FCN
Sbjct: 59 CYASWRNSSGTIELVKKGCWLDDFN----CYDRQECVATEENPQVYFCCCEGNFCNERFT 114
Query: 98 HLPTAS---------PNAPKLGPMELAIIITVPVCLLSIAAMLTVWACQGRQCSYRKKKR 148
HLP A P AP L + + +P+ LS+ +L W YR +K
Sbjct: 115 HLPEAGGPEVTYEPPPTAPTL--LTVLAYSLLPIGGLSLIVLLAFWM-------YRHRKP 165
Query: 149 PNVEEPLSECNLVNAGKTLKDLIYDVTASGSGSGLPLLVQRTIARTIVLQEIVGKGRFGE 208
P + E G P + + L EI +GRFG
Sbjct: 166 PYGHVDIHE----------------------DPGPPPPSPLVGLKPLQLLEIKARGRFGC 203
Query: 209 VWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWL 268
VW + + VAVKIF +D++SW E EI+ T ++HEN+L FIAA+ + + +LWL
Sbjct: 204 VWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFIAAEKRGSNLEVELWL 263
Query: 269 VSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQG---KPAIAHRDIK 325
++ +H++GSL DYL NI+T + +A +++ GL++LH ++ +G KP+IAHRD K
Sbjct: 264 ITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFK 323
Query: 326 SKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDDTMNVNIFES 385
SKN+L+K T +AD GLAV+ + D + +VGT+RYMAPE+L+ +N ++
Sbjct: 324 SKNVLLKSDLTAVLADFGLAVRFEPGKPPGD--THGQVGTRRYMAPEVLEGAINFQ-RDA 380
Query: 386 FKRADIYSVGLVYWEIARRC-SVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQKFRPSI 444
F R D+Y++GLV WE+ RC + G V+EY LP+ + + PS+EE+++VV +K RP+I
Sbjct: 381 FLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTI 440
Query: 445 PNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTIS 483
+ W L + + ECW + ARL+A +++ +S
Sbjct: 441 KDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVS 479
>gi|67782324 transforming growth factor, beta receptor II isoform B
precursor [Homo sapiens]
Length = 567
Score = 227 bits (579), Expect = 2e-59
Identities = 146/497 (29%), Positives = 248/497 (49%), Gaps = 45/497 (9%)
Query: 29 VCLLCDSSNFTCQTEGACWASVMLTNGKEQVIKSCVSL-----PELNAQVFCHSSN---- 79
+C CD TC + +C ++ +T+ E+ + CV++ + + CH
Sbjct: 50 LCKFCDVRFSTCDNQKSCMSNCSITSICEKPQEVCVAVWRKNDENITLETVCHDPKLPYH 109
Query: 80 -----NVTKTEC----------------CFTDFCNNITLHLPTASPNAPKLGPMELAI-- 116
+ +C C +D CN+ + + + P L + +
Sbjct: 110 DFILEDAASPKCIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNTSNPDLLLVIFQVTG 169
Query: 117 IITVPVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKTLKDLIYDVTA 176
I +P ++I+ ++ + + R++K + E L+ + ++ D +
Sbjct: 170 ISLLPPLGVAISVIIIFYCYRVN----RQQKLSSTWETGKTRKLMEFSEHCAIILEDDRS 225
Query: 177 SGSGSGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCG------EDVAVKIFSSRDER 230
S + + T I L +VGKGRF EV+ + E VAVKIF +
Sbjct: 226 DISSTCANNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYA 285
Query: 231 SWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVA 290
SW E +I+ + L+HENIL F+ A+ + Q WL++ +H +G+L +YL R++++
Sbjct: 286 SWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWE 345
Query: 291 GMIKLALSIASGLAHLHMEIVGTQGKPA--IAHRDIKSKNILVKKCETCAIADLGLAVKH 348
+ KL S+A G+AHLH + G+P I HRD+KS NILVK TC + D GL+++
Sbjct: 346 DLRKLGSSLARGIAHLHSDHTPC-GRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRL 404
Query: 349 DSILNTIDIPQNPKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVG 408
D L+ D+ + +VGT RYMAPE+L+ MN+ ESFK+ D+YS+ LV WE+ RC+
Sbjct: 405 DPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAV 464
Query: 409 GIVEEYQLPYYDMVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYAN 468
G V++Y+ P+ V P +E M+ V + RP IP+ W + + ++++ + ECW +
Sbjct: 465 GEVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHD 524
Query: 469 GAARLTALRIKKTISQL 485
ARLTA + + S+L
Sbjct: 525 PEARLTAQCVAERFSEL 541
>gi|67782326 transforming growth factor, beta receptor II isoform A
precursor [Homo sapiens]
Length = 592
Score = 227 bits (579), Expect = 2e-59
Identities = 146/497 (29%), Positives = 248/497 (49%), Gaps = 45/497 (9%)
Query: 29 VCLLCDSSNFTCQTEGACWASVMLTNGKEQVIKSCVSL-----PELNAQVFCHSSN---- 79
+C CD TC + +C ++ +T+ E+ + CV++ + + CH
Sbjct: 75 LCKFCDVRFSTCDNQKSCMSNCSITSICEKPQEVCVAVWRKNDENITLETVCHDPKLPYH 134
Query: 80 -----NVTKTEC----------------CFTDFCNNITLHLPTASPNAPKLGPMELAI-- 116
+ +C C +D CN+ + + + P L + +
Sbjct: 135 DFILEDAASPKCIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNTSNPDLLLVIFQVTG 194
Query: 117 IITVPVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKTLKDLIYDVTA 176
I +P ++I+ ++ + + R++K + E L+ + ++ D +
Sbjct: 195 ISLLPPLGVAISVIIIFYCYRVN----RQQKLSSTWETGKTRKLMEFSEHCAIILEDDRS 250
Query: 177 SGSGSGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCG------EDVAVKIFSSRDER 230
S + + T I L +VGKGRF EV+ + E VAVKIF +
Sbjct: 251 DISSTCANNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYA 310
Query: 231 SWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVA 290
SW E +I+ + L+HENIL F+ A+ + Q WL++ +H +G+L +YL R++++
Sbjct: 311 SWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWE 370
Query: 291 GMIKLALSIASGLAHLHMEIVGTQGKPA--IAHRDIKSKNILVKKCETCAIADLGLAVKH 348
+ KL S+A G+AHLH + G+P I HRD+KS NILVK TC + D GL+++
Sbjct: 371 DLRKLGSSLARGIAHLHSDHTPC-GRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRL 429
Query: 349 DSILNTIDIPQNPKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVG 408
D L+ D+ + +VGT RYMAPE+L+ MN+ ESFK+ D+YS+ LV WE+ RC+
Sbjct: 430 DPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAV 489
Query: 409 GIVEEYQLPYYDMVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYAN 468
G V++Y+ P+ V P +E M+ V + RP IP+ W + + ++++ + ECW +
Sbjct: 490 GEVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHD 549
Query: 469 GAARLTALRIKKTISQL 485
ARLTA + + S+L
Sbjct: 550 PEARLTAQCVAERFSEL 566
>gi|15451916 bone morphogenetic protein receptor type II precursor
[Homo sapiens]
Length = 1038
Score = 197 bits (500), Expect = 2e-50
Identities = 136/417 (32%), Positives = 213/417 (51%), Gaps = 46/417 (11%)
Query: 86 CCFTDFCN-NITLHLPTASPNAPKLGP---MELAIIITVPVCLLSIAAMLTVWACQGRQC 141
CC TD CN N T + P P+ L P I + + +S+ A+L V C G +
Sbjct: 117 CCSTDLCNVNFTENFPP--PDTTPLSPPHSFNRDETIIIALASVSVLAVLIVALCFGYRM 174
Query: 142 SYRKKKRPNVEEPLSECNLVNAGKTLKDLIYDVTASGSGSGLPLLVQRTIARTIVLQEIV 201
+K + L N++ A + L D + L E++
Sbjct: 175 LTGDRK-----QGLHSMNMMEAAASEPSLDLD--------------------NLKLLELI 209
Query: 202 GKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADNKDNG 261
G+GR+G V+ G VAVK+FS + +++ E IY+ ++ H+NI FI D +
Sbjct: 210 GRGRYGAVYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIVGDERVTA 269
Query: 262 TW-TQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIV-GTQGKPAI 319
+ LV EY+ GSL YL+ + +LA S+ GLA+LH E+ G KPAI
Sbjct: 270 DGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRGDHYKPAI 329
Query: 320 AHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQN------PKVGTKRYMAPEM 373
+HRD+ S+N+LVK TC I+D GL+++ N + P +VGT RYMAPE+
Sbjct: 330 SHRDLNSRNVLVKNDGTCVISDFGLSMRLTG--NRLVRPGEEDNAAISEVGTIRYMAPEV 387
Query: 374 LDDTMNVNIFES-FKRADIYSVGLVYWEIARRCS---VGGIVEEYQLPYYDMVPSDPSIE 429
L+ +N+ ES K+ D+Y++GL+YWEI RC+ G V EYQ+ + V + P+ E
Sbjct: 388 LEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEYQMAFQTEVGNHPTFE 447
Query: 430 EMRKVVCDQKFRPSIPNQW-QSCEALRVMGRIMRECWYANGAARLTALRIKKTISQL 485
+M+ +V +K RP P W ++ A+R + + +CW + ARLTA ++ +++L
Sbjct: 448 DMQVLVSREKQRPKFPEAWKENSLAVRSLKETIEDCWDQDAEARLTAQCAEERMAEL 504
>gi|10198656 anti-Mullerian hormone receptor, type II [Homo sapiens]
Length = 573
Score = 170 bits (430), Expect = 3e-42
Identities = 150/505 (29%), Positives = 231/505 (45%), Gaps = 72/505 (14%)
Query: 15 LLAAAAELSPGLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQV-IKSCVSLPELNAQV 73
LL EL ++C+ C C+ LT + QV ++ C E +
Sbjct: 42 LLDTGTELPRAIRCLYSRC------------CFGIWNLTQDRAQVEMQGCRDSDEPGCES 89
Query: 74 F-------CHSSNNVTKTEC-CFTDFCNNITLHLP------TASPNAPKLGPME---LAI 116
H S T C C TDFCN HLP T P+ P E +A+
Sbjct: 90 LHCDPSPRAHPSPGSTLFTCSCGTDFCNANYSHLPPPGSPGTPGSQGPQAAPGESIWMAL 149
Query: 117 IITVPVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKTLKDLIYDVTA 176
++ LL + + A R+ +YR + P V EP +
Sbjct: 150 VLLGLFLLLLLLLGSIILALLQRK-NYRVRGEP-VPEPRPD------------------- 188
Query: 177 SGSGSGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREA 236
SG V+ + +++ +G VW G+ G+ VA+K F R + E
Sbjct: 189 ----SGRDWSVELQELPELCFSQVIREGGHAVVWAGQLQGKLVAIKAFPPRSVAQFQAER 244
Query: 237 EIYQTVMLRHENILGFIAADNKDNGTWTQ-LWLVSEYHEQGSLYDYLNRNIVTVAGMIKL 295
+Y+ L+H++I+ FI A G LV E H +GSL YL + +++
Sbjct: 245 ALYELPGLQHDHIVRFITASRGGPGRLLSGPLLVLELHPKGSLCHYLTQYTSDWGSSLRM 304
Query: 296 ALSIASGLAHLHMEI-VGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILN- 353
ALS+A GLA LH E Q KP IAHRD+ S+N+L+++ +CAI DLGLA+ +
Sbjct: 305 ALSLAQGLAFLHEERWQNGQYKPGIAHRDLSSQNVLIREDGSCAIGDLGLALVLPGLTQP 364
Query: 354 ---TIDIPQNP----KVGTKRYMAPEMLDDTMNVNIF-ESFKRADIYSVGLVYWEIARRC 405
T PQ P + GT+RYMAPE+LD T+++ + + +RADIYS+ L+ WEI RC
Sbjct: 365 PAWTPTQPQGPAAIMEAGTQRYMAPELLDKTLDLQDWGMALRRADIYSLALLLWEILSRC 424
Query: 406 ---SVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMG--RI 460
+QL Y + + P+ +E+ + ++ RP IP+ W+ C A G +
Sbjct: 425 PDLRPDSSPPPFQLAYEAELGNTPTSDELWALAVQERRRPYIPSTWR-CFATDPDGLREL 483
Query: 461 MRECWYANGAARLTALRIKKTISQL 485
+ +CW A+ ARLTA +++ ++ L
Sbjct: 484 LEDCWDADPEARLTAECVQQRLAAL 508
>gi|187475373 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 89.0 bits (219), Expect = 9e-18
Identities = 75/301 (24%), Positives = 143/301 (47%), Gaps = 50/301 (16%)
Query: 193 RTIVLQEIVGKGRFGEVWHGRWCGEDVAVK-IFSSRDERSWFREAEIYQTVMLRHENILG 251
+ + L + +GKG FG+V G + G VAVK I + +++ EA + LRH N++
Sbjct: 193 KELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVM--TQLRHSNLVQ 250
Query: 252 FIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAG---MIKLALSIASGLAHLHM 308
+ ++ G L++V+EY +GSL DYL +V G ++K +L + + +L
Sbjct: 251 LLGVIVEEKGG---LYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL-- 305
Query: 309 EIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRY 368
+G + HRD+ ++N+LV + ++D GL + S +T +P ++
Sbjct: 306 -----EGNNFV-HRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLP-------VKW 352
Query: 369 MAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSI 428
APE L + + ++D++S G++ WEI G V ++P D+V P +
Sbjct: 353 TAPEALREK------KFSTKSDVWSFGILLWEIYS----FGRVPYPRIPLKDVV---PRV 399
Query: 429 EEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQLCVK 488
E+ K+ P++ +M+ CW+ + A R + L++++ + +
Sbjct: 400 EKGYKMDAPDGCPPAV-------------YEVMKNCWHLDAAMRPSFLQLREQLEHIKTH 446
Query: 489 E 489
E
Sbjct: 447 E 447
>gi|4758078 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 89.0 bits (219), Expect = 9e-18
Identities = 75/301 (24%), Positives = 143/301 (47%), Gaps = 50/301 (16%)
Query: 193 RTIVLQEIVGKGRFGEVWHGRWCGEDVAVK-IFSSRDERSWFREAEIYQTVMLRHENILG 251
+ + L + +GKG FG+V G + G VAVK I + +++ EA + LRH N++
Sbjct: 193 KELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVM--TQLRHSNLVQ 250
Query: 252 FIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAG---MIKLALSIASGLAHLHM 308
+ ++ G L++V+EY +GSL DYL +V G ++K +L + + +L
Sbjct: 251 LLGVIVEEKGG---LYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL-- 305
Query: 309 EIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRY 368
+G + HRD+ ++N+LV + ++D GL + S +T +P ++
Sbjct: 306 -----EGNNFV-HRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLP-------VKW 352
Query: 369 MAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSI 428
APE L + + ++D++S G++ WEI G V ++P D+V P +
Sbjct: 353 TAPEALREK------KFSTKSDVWSFGILLWEIYS----FGRVPYPRIPLKDVV---PRV 399
Query: 429 EEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQLCVK 488
E+ K+ P++ +M+ CW+ + A R + L++++ + +
Sbjct: 400 EKGYKMDAPDGCPPAV-------------YEVMKNCWHLDAAMRPSFLQLREQLEHIKTH 446
Query: 489 E 489
E
Sbjct: 447 E 447
>gi|19526767 MLK-related kinase isoform 2 [Homo sapiens]
Length = 455
Score = 82.0 bits (201), Expect = 1e-15
Identities = 78/281 (27%), Positives = 131/281 (46%), Gaps = 57/281 (20%)
Query: 199 EIVGKGRFGEVWHGRWCGED--VAVKIFSSRDERSWFREAEIYQTVMLRHENILGF--IA 254
E G G FG V+ +W +D VAVK + +EAEI +L H NI+ F +
Sbjct: 20 ENCGGGSFGSVYRAKWISQDKEVAVKKLLKIE-----KEAEILS--VLSHRNIIQFYGVI 72
Query: 255 ADNKDNGTWTQLWLVSEYHEQGSLYDYLNRN---IVTVAGMIKLALSIASGLAHLHMEIV 311
+ + G +V+EY GSLYDY+N N + + ++ A +A G+ +LHME
Sbjct: 73 LEPPNYG------IVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHME-- 124
Query: 312 GTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAP 371
+ HRD+KS+N+++ I D G + H+ + VGT +MAP
Sbjct: 125 ---APVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHM------SLVGTFPWMAP 175
Query: 372 EMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSIEEM 431
E++ ++ + E+ D YS G+V WE+ R ++P+ + ++
Sbjct: 176 EVI---QSLPVSET---CDTYSYGVVLWEMLTR----------EVPFKGLEGL-----QV 214
Query: 432 RKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAAR 472
+V ++ R +IP+ SC R ++ +CW A+ R
Sbjct: 215 AWLVVEKNERLTIPS---SCP--RSFAELLHQCWEADAKKR 250
>gi|82880648 MLK-related kinase isoform 1 [Homo sapiens]
Length = 800
Score = 82.0 bits (201), Expect = 1e-15
Identities = 78/281 (27%), Positives = 131/281 (46%), Gaps = 57/281 (20%)
Query: 199 EIVGKGRFGEVWHGRWCGED--VAVKIFSSRDERSWFREAEIYQTVMLRHENILGF--IA 254
E G G FG V+ +W +D VAVK + +EAEI +L H NI+ F +
Sbjct: 20 ENCGGGSFGSVYRAKWISQDKEVAVKKLLKIE-----KEAEILS--VLSHRNIIQFYGVI 72
Query: 255 ADNKDNGTWTQLWLVSEYHEQGSLYDYLNRN---IVTVAGMIKLALSIASGLAHLHMEIV 311
+ + G +V+EY GSLYDY+N N + + ++ A +A G+ +LHME
Sbjct: 73 LEPPNYG------IVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHME-- 124
Query: 312 GTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAP 371
+ HRD+KS+N+++ I D G + H+ + VGT +MAP
Sbjct: 125 ---APVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHM------SLVGTFPWMAP 175
Query: 372 EMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSIEEM 431
E++ ++ + E+ D YS G+V WE+ R ++P+ + ++
Sbjct: 176 EVI---QSLPVSET---CDTYSYGVVLWEMLTR----------EVPFKGLEGL-----QV 214
Query: 432 RKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAAR 472
+V ++ R +IP+ SC R ++ +CW A+ R
Sbjct: 215 AWLVVEKNERLTIPS---SCP--RSFAELLHQCWEADAKKR 250
>gi|4506401 v-raf-1 murine leukemia viral oncogene homolog 1 [Homo
sapiens]
Length = 648
Score = 80.9 bits (198), Expect = 2e-15
Identities = 71/215 (33%), Positives = 107/215 (49%), Gaps = 24/215 (11%)
Query: 192 ARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLR---HEN 248
A ++L +G G FG V+ G+W G DVAVKI D +A + +LR H N
Sbjct: 346 ASEVMLSTRIGSGSFGTVYKGKWHG-DVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVN 404
Query: 249 ILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLN--RNIVTVAGMIKLALSIASGLAHL 306
IL F+ KDN L +V+++ E SLY +L+ + +I +A A G+ +L
Sbjct: 405 ILLFMGYMTKDN-----LAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYL 459
Query: 307 HMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTK 366
H + I HRD+KS NI + + T I D GLA + + Q G+
Sbjct: 460 HAK--------NIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQ--PTGSV 509
Query: 367 RYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEI 401
+MAPE++ M N SF ++D+YS G+V +E+
Sbjct: 510 LWMAPEVI--RMQDNNPFSF-QSDVYSYGIVLYEL 541
>gi|21735566 mitogen-activated protein kinase kinase kinase 7
isoform D [Homo sapiens]
Length = 491
Score = 80.5 bits (197), Expect = 3e-15
Identities = 64/217 (29%), Positives = 99/217 (45%), Gaps = 30/217 (13%)
Query: 193 RTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGF 252
+ I ++E+VG+G FG V +W +DVA+K S ER F E+ Q + H NI+
Sbjct: 34 KEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAF-IVELRQLSRVNHPNIVKL 92
Query: 253 IAADNKDNGTWTQLWLVSEYHEQGSLYDYLN----RNIVTVAGMIKLALSIASGLAHLHM 308
A + LV EY E GSLY+ L+ T A + L + G+A+LH
Sbjct: 93 YGA------CLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLH- 145
Query: 309 EIVGTQGKPAIAHRDIKSKNILVKKCET-CAIADLGLAVKHDSILNTIDIPQNPKVGTKR 367
+ A+ HRD+K N+L+ T I D G A I G+
Sbjct: 146 ----SMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC-------DIQTHMTNNKGSAA 194
Query: 368 YMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARR 404
+MAPE+ + + ++ D++S G++ WE+ R
Sbjct: 195 WMAPEVFEGS------NYSEKCDVFSWGIILWEVITR 225
>gi|21735564 mitogen-activated protein kinase kinase kinase 7
isoform C [Homo sapiens]
Length = 518
Score = 80.5 bits (197), Expect = 3e-15
Identities = 64/217 (29%), Positives = 99/217 (45%), Gaps = 30/217 (13%)
Query: 193 RTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGF 252
+ I ++E+VG+G FG V +W +DVA+K S ER F E+ Q + H NI+
Sbjct: 34 KEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAF-IVELRQLSRVNHPNIVKL 92
Query: 253 IAADNKDNGTWTQLWLVSEYHEQGSLYDYLN----RNIVTVAGMIKLALSIASGLAHLHM 308
A + LV EY E GSLY+ L+ T A + L + G+A+LH
Sbjct: 93 YGA------CLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLH- 145
Query: 309 EIVGTQGKPAIAHRDIKSKNILVKKCET-CAIADLGLAVKHDSILNTIDIPQNPKVGTKR 367
+ A+ HRD+K N+L+ T I D G A I G+
Sbjct: 146 ----SMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC-------DIQTHMTNNKGSAA 194
Query: 368 YMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARR 404
+MAPE+ + + ++ D++S G++ WE+ R
Sbjct: 195 WMAPEVFEGS------NYSEKCDVFSWGIILWEVITR 225
>gi|21735562 mitogen-activated protein kinase kinase kinase 7
isoform B [Homo sapiens]
Length = 606
Score = 80.5 bits (197), Expect = 3e-15
Identities = 64/217 (29%), Positives = 99/217 (45%), Gaps = 30/217 (13%)
Query: 193 RTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGF 252
+ I ++E+VG+G FG V +W +DVA+K S ER F E+ Q + H NI+
Sbjct: 34 KEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAF-IVELRQLSRVNHPNIVKL 92
Query: 253 IAADNKDNGTWTQLWLVSEYHEQGSLYDYLN----RNIVTVAGMIKLALSIASGLAHLHM 308
A + LV EY E GSLY+ L+ T A + L + G+A+LH
Sbjct: 93 YGA------CLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLH- 145
Query: 309 EIVGTQGKPAIAHRDIKSKNILVKKCET-CAIADLGLAVKHDSILNTIDIPQNPKVGTKR 367
+ A+ HRD+K N+L+ T I D G A I G+
Sbjct: 146 ----SMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC-------DIQTHMTNNKGSAA 194
Query: 368 YMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARR 404
+MAPE+ + + ++ D++S G++ WE+ R
Sbjct: 195 WMAPEVFEGS------NYSEKCDVFSWGIILWEVITR 225
>gi|4507361 mitogen-activated protein kinase kinase kinase 7 isoform
A [Homo sapiens]
Length = 579
Score = 80.5 bits (197), Expect = 3e-15
Identities = 64/217 (29%), Positives = 99/217 (45%), Gaps = 30/217 (13%)
Query: 193 RTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGF 252
+ I ++E+VG+G FG V +W +DVA+K S ER F E+ Q + H NI+
Sbjct: 34 KEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAF-IVELRQLSRVNHPNIVKL 92
Query: 253 IAADNKDNGTWTQLWLVSEYHEQGSLYDYLN----RNIVTVAGMIKLALSIASGLAHLHM 308
A + LV EY E GSLY+ L+ T A + L + G+A+LH
Sbjct: 93 YGA------CLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLH- 145
Query: 309 EIVGTQGKPAIAHRDIKSKNILVKKCET-CAIADLGLAVKHDSILNTIDIPQNPKVGTKR 367
+ A+ HRD+K N+L+ T I D G A I G+
Sbjct: 146 ----SMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC-------DIQTHMTNNKGSAA 194
Query: 368 YMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARR 404
+MAPE+ + + ++ D++S G++ WE+ R
Sbjct: 195 WMAPEVFEGS------NYSEKCDVFSWGIILWEVITR 225
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.135 0.419
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,905,518
Number of Sequences: 37866
Number of extensions: 825795
Number of successful extensions: 3059
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 151
Number of HSP's successfully gapped in prelim test: 528
Number of HSP's that attempted gapping in prelim test: 2184
Number of HSP's gapped (non-prelim): 752
length of query: 493
length of database: 18,247,518
effective HSP length: 106
effective length of query: 387
effective length of database: 14,233,722
effective search space: 5508450414
effective search space used: 5508450414
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.