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Search of human proteins with 160420295
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|160420295 hypothetical protein LOC85459 [Homo sapiens]
(2601 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|160420295 hypothetical protein LOC85459 [Homo sapiens] 5067 0.0
gi|239751461 PREDICTED: hypothetical protein XP_002347871 [Homo ... 215 4e-55
gi|71061468 centromere protein E [Homo sapiens] 104 1e-21
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 89 4e-17
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 84 2e-15
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 82 9e-15
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 81 1e-14
gi|148536869 ninein isoform 2 [Homo sapiens] 80 2e-14
gi|148536871 ninein isoform 1 [Homo sapiens] 80 3e-14
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 79 4e-14
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 79 4e-14
gi|109255234 centrosomal protein 290kDa [Homo sapiens] 79 6e-14
gi|148746195 trichohyalin [Homo sapiens] 78 1e-13
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 74 2e-12
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 74 2e-12
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 74 2e-12
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 74 2e-12
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 74 2e-12
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 74 2e-12
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 74 2e-12
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 74 2e-12
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 74 2e-12
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens] 73 3e-12
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 70 3e-11
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 70 4e-11
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 69 5e-11
gi|4506751 restin isoform a [Homo sapiens] 68 1e-10
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 67 2e-10
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 65 7e-10
gi|52145312 hypothetical protein LOC118611 [Homo sapiens] 64 2e-09
>gi|160420295 hypothetical protein LOC85459 [Homo sapiens]
Length = 2601
Score = 5067 bits (13143), Expect = 0.0
Identities = 2601/2601 (100%), Positives = 2601/2601 (100%)
Query: 1 MKRKVVNTHKLRLSPNEEAFILKEDYERRRKLRLLQVREQERDIALQIREDIKQRRNQQF 60
MKRKVVNTHKLRLSPNEEAFILKEDYERRRKLRLLQVREQERDIALQIREDIKQRRNQQF
Sbjct: 1 MKRKVVNTHKLRLSPNEEAFILKEDYERRRKLRLLQVREQERDIALQIREDIKQRRNQQF 60
Query: 61 TRLAEELRAEWEESQTQKIQNLEKLYLASLRSMGEGHRQAKENEPDLDALAQRAAERKRK 120
TRLAEELRAEWEESQTQKIQNLEKLYLASLRSMGEGHRQAKENEPDLDALAQRAAERKRK
Sbjct: 61 TRLAEELRAEWEESQTQKIQNLEKLYLASLRSMGEGHRQAKENEPDLDALAQRAAERKRK 120
Query: 121 ADLRHKEALKVQKNQKEILLKQKTWHIKARKEALLVEKERSAKITSLPPPPPTLFENIEV 180
ADLRHKEALKVQKNQKEILLKQKTWHIKARKEALLVEKERSAKITSLPPPPPTLFENIEV
Sbjct: 121 ADLRHKEALKVQKNQKEILLKQKTWHIKARKEALLVEKERSAKITSLPPPPPTLFENIEV 180
Query: 181 KRISAVKTNSSTYHHLHTFVNRETDTKRPDARLAAEEEAKRLEELQKQAAQERMERFEKA 240
KRISAVKTNSSTYHHLHTFVNRETDTKRPDARLAAEEEAKRLEELQKQAAQERMERFEKA
Sbjct: 181 KRISAVKTNSSTYHHLHTFVNRETDTKRPDARLAAEEEAKRLEELQKQAAQERMERFEKA 240
Query: 241 HVRGFQAMKKIHLAQNQEKLMKELKQLQQEDLARRRQTVAQMPPQLVELPYKRSEMKEDW 300
HVRGFQAMKKIHLAQNQEKLMKELKQLQQEDLARRRQTVAQMPPQLVELPYKRSEMKEDW
Sbjct: 241 HVRGFQAMKKIHLAQNQEKLMKELKQLQQEDLARRRQTVAQMPPQLVELPYKRSEMKEDW 300
Query: 301 QRELEFAFEDMYNADRKVKGNLILHLEPEPLPTVTNQIQDEELDLSMEQENLGAAEDLPV 360
QRELEFAFEDMYNADRKVKGNLILHLEPEPLPTVTNQIQDEELDLSMEQENLGAAEDLPV
Sbjct: 301 QRELEFAFEDMYNADRKVKGNLILHLEPEPLPTVTNQIQDEELDLSMEQENLGAAEDLPV 360
Query: 361 TEAEICSSETDVPLVMKTQQIPSKVLFKKLLNKIRSQKSLWTIKSMSEDESEMITTVSEI 420
TEAEICSSETDVPLVMKTQQIPSKVLFKKLLNKIRSQKSLWTIKSMSEDESEMITTVSEI
Sbjct: 361 TEAEICSSETDVPLVMKTQQIPSKVLFKKLLNKIRSQKSLWTIKSMSEDESEMITTVSEI 420
Query: 421 ESKAPTVESGTIASKERTLSSGQEQVVESDTLTIESGPLASEDKPLSCGTNSGKEQEINE 480
ESKAPTVESGTIASKERTLSSGQEQVVESDTLTIESGPLASEDKPLSCGTNSGKEQEINE
Sbjct: 421 ESKAPTVESGTIASKERTLSSGQEQVVESDTLTIESGPLASEDKPLSCGTNSGKEQEINE 480
Query: 481 TLPITTVAQSSVLLHPQEAAARIRMSARQKQIMEIEEQKQKQLELLEQIEQQKLRLETDC 540
TLPITTVAQSSVLLHPQEAAARIRMSARQKQIMEIEEQKQKQLELLEQIEQQKLRLETDC
Sbjct: 481 TLPITTVAQSSVLLHPQEAAARIRMSARQKQIMEIEEQKQKQLELLEQIEQQKLRLETDC 540
Query: 541 FRAQLEEEKRKKTQPTGVGIAPASCPVISDEDSHRQMIRNYQHQLLQQNRLHRQSVETAR 600
FRAQLEEEKRKKTQPTGVGIAPASCPVISDEDSHRQMIRNYQHQLLQQNRLHRQSVETAR
Sbjct: 541 FRAQLEEEKRKKTQPTGVGIAPASCPVISDEDSHRQMIRNYQHQLLQQNRLHRQSVETAR 600
Query: 601 KQLLEYQTMLKGRCPSVSAPSLITDSVISVPSWKSERPTAISEHWDQGQRLKLSPNKYQP 660
KQLLEYQTMLKGRCPSVSAPSLITDSVISVPSWKSERPTAISEHWDQGQRLKLSPNKYQP
Sbjct: 601 KQLLEYQTMLKGRCPSVSAPSLITDSVISVPSWKSERPTAISEHWDQGQRLKLSPNKYQP 660
Query: 661 IQPIQTSKLEQDHFQVARQNHFPQRQVETTETLRASDILTNQALESQEHLRQFSQTETQQ 720
IQPIQTSKLEQDHFQVARQNHFPQRQVETTETLRASDILTNQALESQEHLRQFSQTETQQ
Sbjct: 661 IQPIQTSKLEQDHFQVARQNHFPQRQVETTETLRASDILTNQALESQEHLRQFSQTETQQ 720
Query: 721 RDYKLVPKDSETLSRALSHDRQLISQDARKISETFGATTFQSLESQQLFSENSENISYHL 780
RDYKLVPKDSETLSRALSHDRQLISQDARKISETFGATTFQSLESQQLFSENSENISYHL
Sbjct: 721 RDYKLVPKDSETLSRALSHDRQLISQDARKISETFGATTFQSLESQQLFSENSENISYHL 780
Query: 781 TEPSSFVPLVPQHSFSSLPVKVESGKIQEPFSAMSKSTVSTSHSIISQMHDRPLLPSENI 840
TEPSSFVPLVPQHSFSSLPVKVESGKIQEPFSAMSKSTVSTSHSIISQMHDRPLLPSENI
Sbjct: 781 TEPSSFVPLVPQHSFSSLPVKVESGKIQEPFSAMSKSTVSTSHSIISQMHDRPLLPSENI 840
Query: 841 TAQQGNMKALQEQLDLQKKVLQATQEAQEQLLLCKQKEVEQQTGLSVFLPLVTPDSSALL 900
TAQQGNMKALQEQLDLQKKVLQATQEAQEQLLLCKQKEVEQQTGLSVFLPLVTPDSSALL
Sbjct: 841 TAQQGNMKALQEQLDLQKKVLQATQEAQEQLLLCKQKEVEQQTGLSVFLPLVTPDSSALL 900
Query: 901 PSAKADLGRIQESSPTKNNIAVSSDHHVISQLQDKRLSLSQPILSQQNNFKFLQEQLNIQ 960
PSAKADLGRIQESSPTKNNIAVSSDHHVISQLQDKRLSLSQPILSQQNNFKFLQEQLNIQ
Sbjct: 901 PSAKADLGRIQESSPTKNNIAVSSDHHVISQLQDKRLSLSQPILSQQNNFKFLQEQLNIQ 960
Query: 961 KDSLQARREAQEVLYVHKQSELDRRVCSEQAEPSFPFQVAQHTFTSLPSADTKSGKIQEQ 1020
KDSLQARREAQEVLYVHKQSELDRRVCSEQAEPSFPFQVAQHTFTSLPSADTKSGKIQEQ
Sbjct: 961 KDSLQARREAQEVLYVHKQSELDRRVCSEQAEPSFPFQVAQHTFTSLPSADTKSGKIQEQ 1020
Query: 1021 HSSKSEKGLVSCQSDIPISQDGSLSFLQQFLPLHDSLKLLQEQLTKQRDTLQARHEAQVE 1080
HSSKSEKGLVSCQSDIPISQDGSLSFLQQFLPLHDSLKLLQEQLTKQRDTLQARHEAQVE
Sbjct: 1021 HSSKSEKGLVSCQSDIPISQDGSLSFLQQFLPLHDSLKLLQEQLTKQRDTLQARHEAQVE 1080
Query: 1081 LLLHRQRDLGDSKSGLVSSSSSPVVVQHSVASQASAKAEPRRIQELYLSEKENVGPSCHL 1140
LLLHRQRDLGDSKSGLVSSSSSPVVVQHSVASQASAKAEPRRIQELYLSEKENVGPSCHL
Sbjct: 1081 LLLHRQRDLGDSKSGLVSSSSSPVVVQHSVASQASAKAEPRRIQELYLSEKENVGPSCHL 1140
Query: 1141 IIPTFQDKSLSFPQHSLAQQENLTILQEQSQIQRVILGAKEGTQEFVHTESELEKRISSE 1200
IIPTFQDKSLSFPQHSLAQQENLTILQEQSQIQRVILGAKEGTQEFVHTESELEKRISSE
Sbjct: 1141 IIPTFQDKSLSFPQHSLAQQENLTILQEQSQIQRVILGAKEGTQEFVHTESELEKRISSE 1200
Query: 1201 QTGTSSSLSQVDESERFQECISIKSDSTIPLSHPKIPRCQERLLRVSQHMLPLQDNLEEH 1260
QTGTSSSLSQVDESERFQECISIKSDSTIPLSHPKIPRCQERLLRVSQHMLPLQDNLEEH
Sbjct: 1201 QTGTSSSLSQVDESERFQECISIKSDSTIPLSHPKIPRCQERLLRVSQHMLPLQDNLEEH 1260
Query: 1261 QAWLDTEKEAFHFSQKTQENTSSEQTGSSSFIPQLVQLSFTSLASAESGTILEPLFTESE 1320
QAWLDTEKEAFHFSQKTQENTSSEQTGSSSFIPQLVQLSFTSLASAESGTILEPLFTESE
Sbjct: 1261 QAWLDTEKEAFHFSQKTQENTSSEQTGSSSFIPQLVQLSFTSLASAESGTILEPLFTESE 1320
Query: 1321 SKIFSSHLQIPQLQDRLLRISQLIQPQQDNLKALQEQLATQREAIILARQEAREELLLHQ 1380
SKIFSSHLQIPQLQDRLLRISQLIQPQQDNLKALQEQLATQREAIILARQEAREELLLHQ
Sbjct: 1321 SKIFSSHLQIPQLQDRLLRISQLIQPQQDNLKALQEQLATQREAIILARQEAREELLLHQ 1380
Query: 1381 SEWEGRISPEQVDTSSLPLVPQHSFASLPLNESERNQEPCSINSDNIVSSGHSEIPTLPD 1440
SEWEGRISPEQVDTSSLPLVPQHSFASLPLNESERNQEPCSINSDNIVSSGHSEIPTLPD
Sbjct: 1381 SEWEGRISPEQVDTSSLPLVPQHSFASLPLNESERNQEPCSINSDNIVSSGHSEIPTLPD 1440
Query: 1441 GLLGLSHLVLPQQDNLIALEEHLHAQTDFLPSIEKTQKELVLSKPCKFEEKVSSEHFIQS 1500
GLLGLSHLVLPQQDNLIALEEHLHAQTDFLPSIEKTQKELVLSKPCKFEEKVSSEHFIQS
Sbjct: 1441 GLLGLSHLVLPQQDNLIALEEHLHAQTDFLPSIEKTQKELVLSKPCKFEEKVSSEHFIQS 1500
Query: 1501 HHGDLQALQQQLDTQKKAIRSIQEVQEELLLQRLSELEKRVSSEQVCSSSFVSQVPVADS 1560
HHGDLQALQQQLDTQKKAIRSIQEVQEELLLQRLSELEKRVSSEQVCSSSFVSQVPVADS
Sbjct: 1501 HHGDLQALQQQLDTQKKAIRSIQEVQEELLLQRLSELEKRVSSEQVCSSSFVSQVPVADS 1560
Query: 1561 ERTQKSFPTKSNDTLPSSHREIPRLQDRLLSLSKPILPQQDNMTAQLDAQREVMYSYEKP 1620
ERTQKSFPTKSNDTLPSSHREIPRLQDRLLSLSKPILPQQDNMTAQLDAQREVMYSYEKP
Sbjct: 1561 ERTQKSFPTKSNDTLPSSHREIPRLQDRLLSLSKPILPQQDNMTAQLDAQREVMYSYEKP 1620
Query: 1621 QEELSLNKQRKLNKSESAEHTIPSLFLPKETEHSFIPLPFAEAKPKSTCELYSSQNEHAA 1680
QEELSLNKQRKLNKSESAEHTIPSLFLPKETEHSFIPLPFAEAKPKSTCELYSSQNEHAA
Sbjct: 1621 QEELSLNKQRKLNKSESAEHTIPSLFLPKETEHSFIPLPFAEAKPKSTCELYSSQNEHAA 1680
Query: 1681 PPSNPVIPGFQDRLLSFSQSVLTQQDNLGLQKQLDLQREVLHYSQKAQEKLLVQRQTALQ 1740
PPSNPVIPGFQDRLLSFSQSVLTQQDNLGLQKQLDLQREVLHYSQKAQEKLLVQRQTALQ
Sbjct: 1681 PPSNPVIPGFQDRLLSFSQSVLTQQDNLGLQKQLDLQREVLHYSQKAQEKLLVQRQTALQ 1740
Query: 1741 QQIQKHEETLKDFFKDSQISKPTVENDLKTQKMGQLRDWFPNTQDLAGNDQENIRHADRN 1800
QQIQKHEETLKDFFKDSQISKPTVENDLKTQKMGQLRDWFPNTQDLAGNDQENIRHADRN
Sbjct: 1741 QQIQKHEETLKDFFKDSQISKPTVENDLKTQKMGQLRDWFPNTQDLAGNDQENIRHADRN 1800
Query: 1801 NSDDNHLASEDTSAKQSGEHLEKDLGRRSSKPPVAKVKCGLDLNQHELSAIQEVESPAIG 1860
NSDDNHLASEDTSAKQSGEHLEKDLGRRSSKPPVAKVKCGLDLNQHELSAIQEVESPAIG
Sbjct: 1801 NSDDNHLASEDTSAKQSGEHLEKDLGRRSSKPPVAKVKCGLDLNQHELSAIQEVESPAIG 1860
Query: 1861 RTSILGKPGIYEDRDPLRVSISREQSFFGSPLAHDPFSCLQLVGQENVCGDDYDEAVKLK 1920
RTSILGKPGIYEDRDPLRVSISREQSFFGSPLAHDPFSCLQLVGQENVCGDDYDEAVKLK
Sbjct: 1861 RTSILGKPGIYEDRDPLRVSISREQSFFGSPLAHDPFSCLQLVGQENVCGDDYDEAVKLK 1920
Query: 1921 ESVVENHAVLSYAVEEEHAYLGPTVKPDDKAKTLSYEPLSSATVSTGSLLSYENTDLSLT 1980
ESVVENHAVLSYAVEEEHAYLGPTVKPDDKAKTLSYEPLSSATVSTGSLLSYENTDLSLT
Sbjct: 1921 ESVVENHAVLSYAVEEEHAYLGPTVKPDDKAKTLSYEPLSSATVSTGSLLSYENTDLSLT 1980
Query: 1981 DPESFSEHMDDSKQESTTSKEEETNIISSIVPSTQDIYQRQNSSDVHKSLLPAVDETTCG 2040
DPESFSEHMDDSKQESTTSKEEETNIISSIVPSTQDIYQRQNSSDVHKSLLPAVDETTCG
Sbjct: 1981 DPESFSEHMDDSKQESTTSKEEETNIISSIVPSTQDIYQRQNSSDVHKSLLPAVDETTCG 2040
Query: 2041 HTHFQQMIDKYINEANLIPEKTDLQELEHIFPNLHHQLFKPLEPHPDFDLSSSSSGISPD 2100
HTHFQQMIDKYINEANLIPEKTDLQELEHIFPNLHHQLFKPLEPHPDFDLSSSSSGISPD
Sbjct: 2041 HTHFQQMIDKYINEANLIPEKTDLQELEHIFPNLHHQLFKPLEPHPDFDLSSSSSGISPD 2100
Query: 2101 NRDFYQRSDSSSESHCATGLSKSTVYFTALRRTSMHSSLNTSPNQQPDTNLAHVGAHSFA 2160
NRDFYQRSDSSSESHCATGLSKSTVYFTALRRTSMHSSLNTSPNQQPDTNLAHVGAHSFA
Sbjct: 2101 NRDFYQRSDSSSESHCATGLSKSTVYFTALRRTSMHSSLNTSPNQQPDTNLAHVGAHSFA 2160
Query: 2161 TENIIGGSEQCFEQLQPEYSSQEESQHADLPSIFSIEARDSSQGMKNQNYPSEEHTEILQ 2220
TENIIGGSEQCFEQLQPEYSSQEESQHADLPSIFSIEARDSSQGMKNQNYPSEEHTEILQ
Sbjct: 2161 TENIIGGSEQCFEQLQPEYSSQEESQHADLPSIFSIEARDSSQGMKNQNYPSEEHTEILQ 2220
Query: 2221 NKKKIVHFQLSIGNLSSVYSSSDEANVFDQLNVQHSTPCGSNSSECSTKHQLESRKESMG 2280
NKKKIVHFQLSIGNLSSVYSSSDEANVFDQLNVQHSTPCGSNSSECSTKHQLESRKESMG
Sbjct: 2221 NKKKIVHFQLSIGNLSSVYSSSDEANVFDQLNVQHSTPCGSNSSECSTKHQLESRKESMG 2280
Query: 2281 FEELSKRGVVTMLQSQGLIEDNKNETCRVLDINPQVEETDSRLCVRTVEMGTSIQAPYSL 2340
FEELSKRGVVTMLQSQGLIEDNKNETCRVLDINPQVEETDSRLCVRTVEMGTSIQAPYSL
Sbjct: 2281 FEELSKRGVVTMLQSQGLIEDNKNETCRVLDINPQVEETDSRLCVRTVEMGTSIQAPYSL 2340
Query: 2341 TTQNEKYFENSAETDIPKITKKLSQLGESELFASSGSFSLQSSIPVWETETGHGIMEEPE 2400
TTQNEKYFENSAETDIPKITKKLSQLGESELFASSGSFSLQSSIPVWETETGHGIMEEPE
Sbjct: 2341 TTQNEKYFENSAETDIPKITKKLSQLGESELFASSGSFSLQSSIPVWETETGHGIMEEPE 2400
Query: 2401 LTLISTTDTSIAEMDFANLTLEEKSENEAKCFFQVSEFLPLVSATEASDYPAVSELSIEK 2460
LTLISTTDTSIAEMDFANLTLEEKSENEAKCFFQVSEFLPLVSATEASDYPAVSELSIEK
Sbjct: 2401 LTLISTTDTSIAEMDFANLTLEEKSENEAKCFFQVSEFLPLVSATEASDYPAVSELSIEK 2460
Query: 2461 PRTASTETPRRLTPVPGSLQEAFIKRKKSFMERSHQRQKEIRNKIHVSENSQIKTVKEKP 2520
PRTASTETPRRLTPVPGSLQEAFIKRKKSFMERSHQRQKEIRNKIHVSENSQIKTVKEKP
Sbjct: 2461 PRTASTETPRRLTPVPGSLQEAFIKRKKSFMERSHQRQKEIRNKIHVSENSQIKTVKEKP 2520
Query: 2521 SISSSVSRLKGVNKVRASFPEDRKTTQALRHQRGLRLYNQLAEVKQQKEEKTKQEAYAQN 2580
SISSSVSRLKGVNKVRASFPEDRKTTQALRHQRGLRLYNQLAEVKQQKEEKTKQEAYAQN
Sbjct: 2521 SISSSVSRLKGVNKVRASFPEDRKTTQALRHQRGLRLYNQLAEVKQQKEEKTKQEAYAQN 2580
Query: 2581 RARAKEFHKKTLEKLRAKNTC 2601
RARAKEFHKKTLEKLRAKNTC
Sbjct: 2581 RARAKEFHKKTLEKLRAKNTC 2601
>gi|239751461 PREDICTED: hypothetical protein XP_002347871 [Homo
sapiens]
Length = 559
Score = 215 bits (548), Expect = 4e-55
Identities = 189/619 (30%), Positives = 297/619 (47%), Gaps = 103/619 (16%)
Query: 24 EDYERRRKLRLLQVREQERDIALQIREDIKQRRNQQFTRLAEELRAEWEESQTQKIQNLE 83
ED R+K +LLQ R + D+ALQ R D K +N Q RLAEELR ++E+Q + L+
Sbjct: 10 EDLLWRKKHKLLQARGKG-DLALQRRADAKLWKNYQLQRLAEELRRGYQEAQHLHVGGLD 68
Query: 84 KLYLASLRSMGEGHRQAKENEPDLDALAQRAAERKRKADLRHKEALKVQKNQKEILLKQK 143
+L S R +G G +A+ENEPD QR + R +A +H+ AL +++ +E L +Q
Sbjct: 69 RLQ--SARLLGWGGGRARENEPDSQGPIQRRSARPPRAKEKHRAALSEERSCREELGQQH 126
Query: 144 TWHIKARKEALLVEKERSAKITS-----LPPPPPTLFENIEVKRISAVKTNSSTYHHLHT 198
H + RK A EK ++ K T L PP E + + + K+ +H
Sbjct: 127 PRHSRPRKTAASPEKPQTTKATGRMNSHLAPP-----EKRKGRPEPSTKSGGGRC-AIHP 180
Query: 199 FVNRETDTKRPDARLAAEEEAKRLEELQKQAAQERMERFEKAHVRGFQAMKKIHLAQNQE 258
++ D +R + +AA E +EE +K A+ + K V A+ Q+ E
Sbjct: 181 RRSKGADLERSNPLVAAVGEIGLVEEKEKGTARAGRRQLGKGAVCFVPALTSRSQGQSLE 240
Query: 259 KLMKELKQLQQEDLARRRQTVAQMPPQLVELPYKRSEMKEDWQRELEFAFEDMYNADRKV 318
+++L QL D + RR+ V+ P L K WQ+ELE AFE+++N +RK+
Sbjct: 241 GKLRDLGQLWPADSSCRREAVS--PASQCTL-----REKNKWQKELELAFEELFNINRKL 293
Query: 319 KGNLILHLEPEPLPTVTNQIQDEELDLSMEQENLGAAEDLPVTEAEIC-SSETDVPLVMK 377
K +L L+L + P + + + M++ G + + E+ + E P +
Sbjct: 294 KKHLCLYLALK--PRMDQRPGEGHAFSEMQECGAGTPRGKKMADPEMLPAGEPRSPAEEE 351
Query: 378 TQQIPSKVLFKKLLNKIRSQKSLWTIKSMSEDESEMITTVSEIESKAPTVESGTIASKER 437
QQ SK K + K ++QK T+K PT +G
Sbjct: 352 AQQAASKTDLKTFMGKAQNQKYQGTVK--------------------PTFRNG------- 384
Query: 438 TLSSGQEQVVESDTLTIESGPLASEDKPLSCGTNSGKEQEINETLPITTVAQSSVLLHPQ 497
S TL+ E+G +++ L T SG+ ET + T+A+ S+ LH Q
Sbjct: 385 -----------SQTLSPEAGIFINKEDSLLYSTESGQ-----ETPKLGTLAEGSLQLHLQ 428
Query: 498 EAAARIRMSA-RQKQIMEIEEQKQKQLELLEQIEQQKLRLETDCFRAQLEEEKRKK---- 552
+ A R+ +A RQ+Q E+E+++QKQLE LEQ+E + LE ++A+LE+E+R++
Sbjct: 429 DQADRVGSTASRQRQKAEMEQRRQKQLESLEQMEHPDMSLEIH-YKAELEKERREQRRAR 487
Query: 553 ----------------------TQPTGVGIAPASCPVISDEDSHRQMIRNYQHQLLQQNR 590
T P+G +A D+D H QMIR+ Q Q+LQQNR
Sbjct: 488 LAHLKSSSTRAQERERGSELSTTSPSGTSLA--------DDDRHSQMIRDQQQQILQQNR 539
Query: 591 LHRQSVETARKQLLEYQTM 609
LH+Q +E ARK L E+Q +
Sbjct: 540 LHKQFLEEARKCLREFQNI 558
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 104 bits (260), Expect = 1e-21
Identities = 359/1967 (18%), Positives = 781/1967 (39%), Gaps = 344/1967 (17%)
Query: 16 NEEAFILKEDYERRRKLRLLQVREQERDIALQIREDIKQRRNQQFTRLAEELRAEWEESQ 75
++E ++ E + ++ +V Q+ + L + ++ + + Q +L E +
Sbjct: 547 DQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYI-------D 599
Query: 76 TQKIQNLEKLYLASLRSMGEGHRQAKENEPDLDALA---QRAAERKRKADLRHKEALK-- 130
+QK++N++ SL S+ E +Q K+ D + +A +R + R +L KE +K
Sbjct: 600 SQKLENIKMDLSYSLESI-EDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKEL 658
Query: 131 ---VQKNQKEILLKQKTWHIKARKEALLVEKERSA-----KITSL--PPPPPTLFENIEV 180
++ + +I L Q K + + L ++ +SA K+TSL P L N+E+
Sbjct: 659 ATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLEL 718
Query: 181 KRISAVKTNSSTYHHLHTFVNRETDTKRPDARLAAEEEAKRLEELQ------KQAAQERM 234
+ L +N+E + A EE L EL+ ++ +E
Sbjct: 719 E---------GKITDLQKELNKEVEENE-----ALREEVILLSELKSLPSEVERLRKEIQ 764
Query: 235 ERFEKAHVRGFQAMKK----IHLAQNQEKLMKELKQLQQEDLARRRQTVAQMPPQLVELP 290
++ E+ H+ + K +H + L++E+ + + +DLA + +
Sbjct: 765 DKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTK-DDLATTQSNYKSTDQEFQNFK 823
Query: 291 YKRSEMKEDWQ---RELEFAFEDMYNADRKV-KGNLILHLEPEPLPTVTNQIQDEELDLS 346
+ ++ ++ E E +++ N ++ K + L L T ++Q++ ++
Sbjct: 824 TLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREV- 882
Query: 347 MEQENLGAAEDLPVTEAEICSSETDVPLVMKTQQIPSKVLFKKLLNKIRSQKSLWTIKSM 406
QE L E L + ++ + ++ + V + + + ++ L Q++L +K++
Sbjct: 883 --QERLNEMEQL---KEQLENRDSTLQTVEREKTLITEKL----------QQTLEEVKTL 927
Query: 407 SEDESEMITTVSEIESKAPTVESG-------TIASKERTLSSGQEQVVESDTLTIESGPL 459
++++ ++ ++ + ++S I ++E+ ++ + +T+ +
Sbjct: 928 TQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKI 987
Query: 460 ASE-DKPLSCGTNSGK-EQEINETLPITTVAQSSVLLHPQEAAARIR---MSARQKQIME 514
+ E + L N+G+ + E + + Q + Q A ++ + +Q++I
Sbjct: 988 SEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFS 1047
Query: 515 IEEQKQKQLELLEQIEQQKLRLETDC-FRAQLEEEKRKKTQPTGVGIAPASCPVISDEDS 573
+ ++K + ++LE + +K +L+TD ++ E +++ + G + +++ E +
Sbjct: 1048 LIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQ-EIVAQEKN 1106
Query: 574 HR-----QMIRNYQHQLLQQNRLHR--QSVETARKQLLEYQTMLKGRCPSV----SAPSL 622
H ++ R + +L Q ++ ++QLL Q + + + +
Sbjct: 1107 HAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNE 1166
Query: 623 ITDSVISVPSWKSERPTAISEHWDQGQRLKLSPNKYQPIQPIQTS-KLEQDHFQVARQNH 681
+ + +++ ++ER + + + +K + + ++ +Q S + E+DH +
Sbjct: 1167 LKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLR-GYIRE 1225
Query: 682 FPQRQVETTETLRASDILTNQALESQEHLRQ-FSQTETQQRDYKLVPKDSETLSRALS-- 738
++T E L+ + I + E+ + LR+ S+ Q + + + K L +
Sbjct: 1226 IEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVL 1285
Query: 739 HDRQLISQDARKISETFGATTFQSLESQQLFSENSENISYHLTEPSSFVPLVPQHSFSSL 798
H+ Q + + +++SET T LE LTE S+ + S +
Sbjct: 1286 HEEQELLPNVKEVSET--QETMNELEL--------------LTEQST-----TKDSTTLA 1324
Query: 799 PVKVESGKIQEPFSAMSKSTVSTSHSIISQMHDRPLLPSENITAQQGNMKALQEQLDLQK 858
+++E ++ E F + +++T ++ N+K ++E L+++
Sbjct: 1325 RIEMERLRLNEKFQESQEEI-------------------KSLTKERDNLKTIKEALEVKH 1365
Query: 859 KVL-----------QATQEAQEQLLLCKQKEVEQQTGLSVFLPLVTPDSSALLPSAKADL 907
L Q +Q QEQ L K+K+ + T + + P SALL L
Sbjct: 1366 DQLKEHIRETLAKIQESQSKQEQSLNMKEKD-NETTKIVSEMEQFKPKDSALLRIEIEML 1424
Query: 908 G---RIQESSPTKNNIAVSSDHHVISQLQDKRLSLSQPILSQQNNFKFLQEQLNIQKDSL 964
G R+QES ++A ++++ + LQE L Q +S
Sbjct: 1425 GLSKRLQESHDEMKSVA-----------------------KEKDDLQRLQEVL--QSESD 1459
Query: 965 QARREAQEVLYVHKQSELDRRV---CSEQAEPSFPFQVAQHTFTSLPSADTKSGKIQEQH 1021
Q + +E++ H ++E + +V C ++ E + +L +T+ IQ+Q
Sbjct: 1460 QLKENIKEIVAKHLETEEELKVAHCCLKEQE-----ETINELRVNLSEKETEISTIQKQL 1514
Query: 1022 SSKSEKGLVSCQSDIPISQDGSLSFLQQFLPLHDSLKLLQEQLTKQRDTLQARHEAQVEL 1081
+ ++K Q + ++ + + + LK +E + LQ+ +EL
Sbjct: 1515 EAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLEL 1574
Query: 1082 LLHRQRDLGDSKSGLVSSSSSPVVVQHSVASQASAKAEPRRIQELYLSEKENVGPSCHLI 1141
Q Q + K E +R+QE E++ + + I
Sbjct: 1575 TNRLQES------------------QEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEI 1616
Query: 1142 IPTF---QDKSLSFPQHSLAQQE-----NLTILQEQSQIQRVILGAKEGTQEFVHTESEL 1193
+ Q+K F + + + + L+EQ + Q++ L E + TE+
Sbjct: 1617 VAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNL-------ENIETENIR 1669
Query: 1194 EKRISSEQTGTSSSLS-QVDESERFQECISIKSDSTIPLSHPKIPRCQERLLRVSQHMLP 1252
+I E S++ + D+ +E + ++ D I R E+ + +
Sbjct: 1670 LTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEK----QEELKI 1725
Query: 1253 LQDNLEEHQAWLDTEKEAFHFSQKTQENTSSEQTGSSSFIPQLVQLSFTSLASAESGTIL 1312
+ +L+EHQ +D K S+KT E ++ ++ L +
Sbjct: 1726 VHMHLKEHQETID--KLRGIVSEKTNEISNMQK----------------DLEHSNDALKA 1767
Query: 1313 EPLFTESESKIFSSHLQIPQLQDRLLRISQLIQPQQDNLKALQEQLATQREAIILARQEA 1372
+ L + E +I +H+ + + Q+ + ++ ++ + D L +Q+ L + QE
Sbjct: 1768 QDLKIQEELRI--AHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKL----QEK 1821
Query: 1373 REELLLHQSE---WEGRISPEQVDTSSL-PLVPQHSFASLPLNESERNQEPCSINSDNIV 1428
+EL ++ + + ++ Q S + L Q SL L++ E I + N+
Sbjct: 1822 IQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLE-------IENLNLA 1874
Query: 1429 SSGHSEIPTLPDGLLGLSHLVLPQQDNLIALEEHLHAQTDFL-PSIEKTQ-KELVLSKPC 1486
H + + V+ ++DNL +EE L + D L S+++T+ ++L + +
Sbjct: 1875 QKLHENLEEMKS--------VMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQEL 1926
Query: 1487 KFEEKVSSEH---------FIQSHHGDLQALQQQLDTQKKAI-RSIQEVQ-EELLLQRLS 1535
K +S EH I + +Q+ LD K + + IQE+Q +EL L R+
Sbjct: 1927 KTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVK 1986
Query: 1536 E----LEKRVSSEQVCSSSFVSQVPVADSERTQKSFPTKSNDTLPSSHREIPRLQDRLLS 1591
E K+++ + F +Q S R TK R + + +D L
Sbjct: 1987 EDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRR 2046
Query: 1592 LSKPILPQQDNMTAQLDAQ--REVMYSYEKPQEELSLNKQRKLNK--------------- 1634
+ + + ++D A L R+ KP++ L + Q+ L +
Sbjct: 2047 IKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKR 2106
Query: 1635 -SESAEH----TIPSLFLPKETE---------HSFIPLPFAEAKPKSTCELYSSQNEHAA 1680
SE +H SL L KE E + + LP+ + K E + N+ +
Sbjct: 2107 YSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTK---HIEKLFTANQRCS 2163
Query: 1681 PPSNPVIPGFQDRLLSFSQSVLTQQDNLG---------LQKQLDLQREVLHYSQKAQEKL 1731
+ ++ + L ++ Q +++ ++KQ +L ++ H Q
Sbjct: 2164 MEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPS 2223
Query: 1732 LVQRQTALQQQIQKH-EETLKDFFKDSQISKPTVENDLK-----TQKMGQ-LRDWFPNTQ 1784
R L Q + H EE LKDF S+ P+++ + + ++M Q L +W
Sbjct: 2224 RELRDLKLNQNMDLHIEEILKDF---SESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRF 2280
Query: 1785 DLA----GNDQENIRHADRNNSDDNH---LASEDTSAKQSGEHLEKD 1824
D+ G +EN R NN +N + +E T ++ + K+
Sbjct: 2281 DIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKE 2327
Score = 65.1 bits (157), Expect = 9e-10
Identities = 229/1187 (19%), Positives = 475/1187 (40%), Gaps = 192/1187 (16%)
Query: 8 THKLRLSPNEEAFILKEDYERRRKLRLLQV-----REQERDIALQIREDIKQRRNQQFTR 62
T++L+ S E ++KE E +R LQ+ +E ++I +++E Q + QF +
Sbjct: 1575 TNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKE--SQEKEYQFLK 1632
Query: 63 LAE---------ELRAEWEESQTQKIQNLEKLYLASLRSMGEGHRQAKENEPDLDALAQR 113
+ E+ E+ +TQK+ NLE + ++R H + L +
Sbjct: 1633 MTAVNETQEKMCEIEHLKEQFETQKL-NLENIETENIRLTQILH----------ENLEEM 1681
Query: 114 AAERKRKADLRH-KEALKVQKNQ-KEILLKQKTWHIKARKEALLVE---KERSAKITSLP 168
+ K + DLR +E LKV+++Q KE L + T ++ ++E +V KE I L
Sbjct: 1682 RSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKL- 1740
Query: 169 PPPPTLFENIEVKRISAVKTNSSTYHHLHTFVNRETDTKRPDARLAAE----EEAKRLEE 224
+ I + KTN + N + D + + L A+ +E R+
Sbjct: 1741 ------------RGIVSEKTNEIS--------NMQKDLEHSNDALKAQDLKIQEELRIAH 1780
Query: 225 LQKQAAQERMERFEKAHVRGFQAMKKIHLAQNQEKLMKELKQLQQ--EDLARRRQTVAQM 282
+ + QE +++ +RG + K L+ Q+ L +LQ+ ++L + +
Sbjct: 1781 MHLKEQQETIDK-----LRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITL 1835
Query: 283 PPQLVELPYKRSEM----KEDWQRELEFAFEDMYNADRKVKGNLILHLEPEPLPTVTNQ- 337
+ E K SEM K+ + L + ++ N + K LH E + +V +
Sbjct: 1836 KKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQK----LHENLEEMKSVMKER 1891
Query: 338 --IQDEELDLSMEQENLGAAEDLPVTEAEICSSETDVPLVMKTQQIPSKVLFKKLLNKIR 395
++ E L +E++ L E L T+A + ++ +KT ++ SK K+ ++K+R
Sbjct: 1892 DNLRRVEETLKLERDQL--KESLQETKAR----DLEIQQELKTARMLSKE-HKETVDKLR 1944
Query: 396 SQKSLWTIKSMSEDESEMITTVSEIESKAPTVESGTIASKERTLSSGQEQVVESDTLTIE 455
+ S TI+ +S+ + ++ + E++ K ++ KE L +E V S E
Sbjct: 1945 EKISEKTIQ-ISDIQKDLDKSKDELQKKIQELQ-----KKELQLLRVKEDVNMSHKKINE 1998
Query: 456 SGPLASEDKPLSCGTNSGKEQEINETLPITTVAQSSVLLHPQEAAARIRMSARQKQIMEI 515
+++ + ++ SV + + ++ S + +I+
Sbjct: 1999 M-------------------EQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAK 2039
Query: 516 EEQKQKQLELLEQIEQQKLRLETDCFRAQLEEEKRKKTQPTGVGIAPASCPVISDEDSH- 574
E + +++ ++ L++E D F A L E + Q V ++SD H
Sbjct: 2040 ERDELRRI-------KESLKMERDQFIATLREMIARDRQNHQV---KPEKRLLSDGQQHL 2089
Query: 575 -----------RQMIRNYQHQLLQQNRLHRQSVETARKQLLEYQTMLKGRC-PSVSAPSL 622
+++++ Y L+R S++ ++ +E+Q L R ++S P L
Sbjct: 2090 TESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKE--IEFQKELSMRVKANLSLPYL 2147
Query: 623 ITDSVISVPSWKSERPTAISEHWDQGQRLKLSPNKYQPIQPIQTSKLEQDHF-QVARQ-- 679
T + + + + + + K + Q +K E D +V +Q
Sbjct: 2148 QTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKE 2207
Query: 680 -----NHFPQRQVETTETLRASDILTNQALESQEHLRQFSQTE--TQQRDYKLVPKDSET 732
H Q + LR + N L +E L+ FS++E + + +++ V + +
Sbjct: 2208 LLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKE 2267
Query: 733 LSRALSHDRQLISQ-DARKISETFGATTFQSLESQQLFSEN---SENISYHLTEPSSFVP 788
+++ L + L ++ D K+ + + F+ N S E S+ +
Sbjct: 2268 MTQFL--EEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATIS 2325
Query: 789 LVPQHSFSSLPVKVESGKIQEPFSAMSKSTVSTSH-SIISQMHDRPLLPSENITAQQGNM 847
+ SL K E K+ + + + S S + + +Q + P + S +
Sbjct: 2326 KEWEQDLKSLKEKNE--KLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKI 2383
Query: 848 KALQEQLDLQKKVLQATQEAQEQLLLCKQKEVEQQTGLSVFLPLVTPDSSALLPSAKADL 907
+ L+ L K+ + +E ++ QKE+E + L +S+ L K +
Sbjct: 2384 RELENSLHEAKE----SAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETI 2439
Query: 908 GRIQESSPTKNNIAVSSDHHVISQLQDKRLSLSQPILSQQNNFKFLQEQLNIQKDSLQAR 967
+Q+ +A+ + + +++D ++ L + L + N K +++++ K +++ +
Sbjct: 2440 QVLQD------KVALGAKPYK-EEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQ 2492
Query: 968 REAQEVLYVH---KQSELDRRVCSEQAEPSFPFQVAQHTFTSLPSADTKSGKIQEQHSSK 1024
+E +L + Q D V SE +P Q + T SG +Q
Sbjct: 2493 KEVIRLLRENLRRSQQAQDTSVISEHTDP----QPSNKPLT----CGGGSGIVQ------ 2538
Query: 1025 SEKGLVSCQSDIPISQDGSLSFLQQFLPLHDSLKLLQEQLTKQRDTLQARHE-AQVELLL 1083
+ K L+ I + ++ S LK EQL KQ++ L + ++ E+
Sbjct: 2539 NTKALILKSEHIRLEKEIS------------KLKQQNEQLIKQKNELLSNNQHLSNEVKT 2586
Query: 1084 HRQRDLGDSKSGLVSSSSSPVVVQHSVASQASAKAEPRRIQELYLSE 1130
++R L V+ +SP + + + + P + +E L +
Sbjct: 2587 WKERTLKREAHKQVTCENSPKSPKVTGTASKKKQITPSQCKERNLQD 2633
Score = 62.4 bits (150), Expect = 6e-09
Identities = 232/1301 (17%), Positives = 508/1301 (39%), Gaps = 226/1301 (17%)
Query: 703 ALESQEHLRQFSQTETQQRDYKLVPKDSETLSRALSHDRQLISQDARKISETFGATTFQS 762
+LES E +Q QT D + V D++ S L + + + +++ ATT++
Sbjct: 613 SLESIEDPKQMKQTLF---DAETVALDAKRESAFLRSENLELKEKMKEL-----ATTYKQ 664
Query: 763 LESQ-QLFSENSENISYHLTEPSSFVPLVPQHSFSSLPVKVESGKIQEPFSAMSKSTVST 821
+E+ QL+ E + + V +E ++Q F+ ++K T
Sbjct: 665 MENDIQLYQSQLE-------------------AKKKMQVDLEK-ELQSAFNEITKLT--- 701
Query: 822 SHSIISQMHDRPLLPSENITAQQGNMKALQEQLDLQKKVLQATQEAQEQLLLCKQKEVEQ 881
S+I + LL + + +G + LQ++L+ + + +A +E E +LL + K +
Sbjct: 702 --SLIDGKVPKDLLCNLEL---EGKITDLQKELNKEVEENEALRE--EVILLSELKSLPS 754
Query: 882 QT--------GLSVFLPLVTPDSSALLPSAKADLGRIQ----ESSPTKNNIAVSSDHHVI 929
+ S L ++T + L R+Q E TK+++A + ++
Sbjct: 755 EVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKS 814
Query: 930 SQLQDKRLSLSQPILSQQNNFKFLQEQLNIQKDSLQARREAQEVLYVHKQSELDRRVCSE 989
+ + + Q+ L+E + ++ + +EAQ+ D + +
Sbjct: 815 TDQEFQNFKTLHMDFEQKYKM-VLEENERMNQEIVNLSKEAQK---------FDSSLGAL 864
Query: 990 QAEPSFPFQVAQHTFTSLPSADTKSGKIQEQHSSKSEKGLVSCQSDIPISQDGSLSFLQQ 1049
+ E S+ Q Q + + +++EQ ++ + L + + + + + L++
Sbjct: 865 KTELSYKTQELQEKTREVQERLNEMEQLKEQLENR-DSTLQTVEREKTLITEKLQQTLEE 923
Query: 1050 FLPL---HDSLKLLQEQLTKQRDTLQARHEAQVELLLHRQRDLGDSKSGLVSSSSSPVVV 1106
L D LK LQE L +RD L++ V + + Q L ++ L + +
Sbjct: 924 VKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTL 983
Query: 1107 QHSVASQAS----AKAEPRRIQELYLSEKENVGPSCHLIIPTFQDKSLSFPQHSLAQQEN 1162
+ ++ + S + ++ + + + L Q + + + +Q+
Sbjct: 984 KSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQR 1043
Query: 1163 --LTILQEQSQIQRV---ILGAKEGTQEFVHTESELEKRISSEQTGTSSSLSQVDESERF 1217
+++QE++++Q++ ++ KE + + E+ E L + E
Sbjct: 1044 KIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQ 1103
Query: 1218 QECISIKSDSTIPLSHPKIPRCQERLLRVS-------QHMLPLQDNLEEHQAWLD----- 1265
++ +IK + + + ++ +E+L S Q +L +Q+ + E Q ++
Sbjct: 1104 EKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENL 1163
Query: 1266 -------------TEKEAFHFSQKTQENTSSEQ--TGSSSFIPQLVQLSFTSLASAESGT 1310
E E +QK EN + T + +L Q SF + G
Sbjct: 1164 KNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKEL-QKSFETERDHLRGY 1222
Query: 1311 ILE----PLFTESESKIFSSHL------------------------------------QI 1330
I E L T+ E KI HL +I
Sbjct: 1223 IREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEI 1282
Query: 1331 PQL---QDRLLRISQLIQPQQ--DNLKALQEQLATQREAIILAR------------QEAR 1373
P L Q+ L + ++ + Q+ + L+ L EQ +T +++ LAR QE++
Sbjct: 1283 PVLHEEQELLPNVKEVSETQETMNELELLTEQ-STTKDSTTLARIEMERLRLNEKFQESQ 1341
Query: 1374 EELLLHQSEWEGRIS------------PEQVDTSSLPLVPQHSFASLPLNESERNQEPCS 1421
EE+ E + + E + + + S LN E++ E
Sbjct: 1342 EEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTK 1401
Query: 1422 INSD-NIVSSGHSEIPTLPDGLLGLS----------HLVLPQQDNLIALEEHLHAQTDFL 1470
I S+ S + + +LGLS V ++D+L L+E L +++D
Sbjct: 1402 IVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESD-- 1459
Query: 1471 PSIEKTQKELVLSKPCKFEEKVSSEH-FIQSHHGDLQALQQQLDTQKKAIRSIQEVQEEL 1529
+++ KE+V +K + EE++ H ++ + L+ L ++ I +IQ+ E +
Sbjct: 1460 -QLKENIKEIV-AKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAI 1517
Query: 1530 LLQRLSELEKRVSSEQVCSSSFVSQVPVADSERTQKSFPTKSNDTLPSSHREIPRLQDRL 1589
+ +++++ E+ + +S+V +E Q K+ D+ S ++ ++
Sbjct: 1518 NDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQS------IESKM 1571
Query: 1590 LSLSKPILPQQDNMTAQLDAQREVMYSYEKPQEELSLNKQRKLNKSESAEHTIPSLFLPK 1649
L L+ + Q+ + + + E+ ++ QE L + + + E+ + + + +
Sbjct: 1572 LELTNRLQESQEEIQIMIKEKEEM----KRVQEALQIERDQ---LKENTKEIVAKMKESQ 1624
Query: 1650 ETEHSFIPLPFAEAKPKSTCEL------YSSQ--NEHAAPPSNPVIPGFQDRLLSFSQSV 1701
E E+ F+ + + CE+ + +Q N N + L +SV
Sbjct: 1625 EKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSV 1684
Query: 1702 LTQQDNL-GLQKQLDLQREVLHYSQKAQEKLLVQRQTALQ---QQIQKHEETLKDFFKDS 1757
++D+L +++ L ++R+ L + + +++Q L+ +++H+ET+
Sbjct: 1685 TKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKL--RG 1742
Query: 1758 QISKPTVENDLKTQKMGQLRDWFPNTQDLAGNDQENIRHADRNNSDD-----NHLASEDT 1812
+S+ T E + + D QDL ++ I H + + SE T
Sbjct: 1743 IVSEKTNEISNMQKDLEHSNDAL-KAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKT 1801
Query: 1813 SAKQSGEHLEKDLGRRSSKPPVAKVKCGLDLNQHELSAIQE 1853
+++KDL ++K + + L N+H+L +++
Sbjct: 1802 DKL---SNMQKDLENSNAK--LQEKIQELKANEHQLITLKK 1837
Score = 62.4 bits (150), Expect = 6e-09
Identities = 200/982 (20%), Positives = 388/982 (39%), Gaps = 164/982 (16%)
Query: 6 VNTHKLRLSPNEEAFILKEDYERRRKLRLLQVREQERDIALQIREDIKQRRNQQFTRLAE 65
+ T +RL+ IL E+ E R + +ERD + E +K R+Q L E
Sbjct: 1663 IETENIRLTQ-----ILHENLEEMRSVT------KERDDLRSVEETLKVERDQ----LKE 1707
Query: 66 ELRAEWEESQTQKIQNLEKLYLASLRSMGEGHRQAKENEPDLDALAQRAAER-----KRK 120
LR E+ T+ ++ E+L + H KE++ +D L +E+ +
Sbjct: 1708 NLR----ETITRDLEKQEELKIV--------HMHLKEHQETIDKLRGIVSEKTNEISNMQ 1755
Query: 121 ADLRH-KEALKVQKNQKEILLKQKTWHIKARKEAL----LVEKERSAKITSLPPPPPTLF 175
DL H +ALK Q + + L+ H+K ++E + + E++ K++++
Sbjct: 1756 KDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKD----L 1811
Query: 176 ENIEVKRISAVKTNSSTYHHLHTFVNRETDTKRPDARLAAEEEAKRLEELQKQAAQERME 235
EN K ++ + H L T +T +++ +E+L+KQ + +
Sbjct: 1812 ENSNAKLQEKIQELKANEHQLITLKKDVNET---------QKKVSEMEQLKKQIKDQSL- 1861
Query: 236 RFEKAHVRGFQAMKKIHLAQNQEKLMKELKQLQQEDLARRRQTVAQMPPQLVELPYKRSE 295
K + +K+H +N E++ +K ++++L R +T+ QL E +
Sbjct: 1862 TLSKLEIENLNLAQKLH--ENLEEMKSVMK--ERDNLRRVEETLKLERDQLKESLQETKA 1917
Query: 296 MKEDWQRELEFA-------FEDMYNADRKVKGNLI--------LHLEPEPLPTVTNQIQD 340
+ Q+EL+ A E + K+ I L + L ++Q
Sbjct: 1918 RDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQK 1977
Query: 341 EELDLSMEQENLGAAEDLPVTEAEICSSETDVP-LVMKTQQIPSKVLFKKL---LNKIR- 395
+EL L +E++ + + E E + + L M++ ++ + L KKL L +IR
Sbjct: 1978 KELQLLRVKEDVNMSHK-KINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRI 2036
Query: 396 ---SQKSLWTIK-SMSEDESEMITTVSEIESKAPTVESGTIASKERTLSSGQEQVVES-- 449
+ L IK S+ + + I T+ E+ ++ ++ + ++R LS GQ+ + ES
Sbjct: 2037 VAKERDELRRIKESLKMERDQFIATLREMIAR--DRQNHQVKPEKRLLSDGQQHLTESLR 2094
Query: 450 ---DTLTIESGPLASEDKPLSC----GTNSGKEQEINETLPITTVAQSSVLLHPQEAAAR 502
+ + D C + KE E + L + A S L + Q
Sbjct: 2095 EKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLS-LPYLQTKHIE 2153
Query: 503 IRMSARQKQIMEI------------------EEQKQK----QLELLEQIEQQK------L 534
+A Q+ ME EEQ + +++ ++++E+QK
Sbjct: 2154 KLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQ 2213
Query: 535 RLETDCFRAQLEEEKRKKTQPTGVGIAPASCPVISD-EDSHRQMIRNYQHQLLQQNRLHR 593
L+ DC E K Q + I ++ D +S I+ Q+L +
Sbjct: 2214 HLQQDCDVPSRELRDLKLNQNMDLHIE----EILKDFSESEFPSIKTEFQQVLSNRKEMT 2269
Query: 594 QSVETARKQLLEYQTMLKG------RCPSVSAPSLITDSVISVPSWKS---ERPTAISEH 644
Q +E + + + G R V+ + + +I++ + + ER IS+
Sbjct: 2270 QFLEEWLNTRFDIEKLKNGIQKENDRICQVN--NFFNNRIIAIMNESTEFEERSATISKE 2327
Query: 645 WDQGQRLKLSPNK--YQPIQPIQTSKLEQDHFQVARQN----HFPQRQVE-TTETLRASD 697
W+Q + N+ ++ Q ++TS Q+ H R + TTE +R +
Sbjct: 2328 WEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELE 2387
Query: 698 ILTNQALESQEHLRQFSQTETQQRDYKLVPKDSETLSRALSHDRQLISQDARKISETFGA 757
++A ES H + S+ Q++ + V D +A H+ ++ K ET
Sbjct: 2388 NSLHEAKESAMH--KESKIIKMQKELE-VTNDIIAKLQAKVHES---NKCLEKTKETIQV 2441
Query: 758 TTFQSLESQQLFSENSEN-----ISYHLTEPSSFVPLVPQHSFSSLPVKVESGKIQEPFS 812
+ + + E E+ + L + + + S + V+ + I+
Sbjct: 2442 LQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRE 2501
Query: 813 AMSKSTVSTSHSIISQMHDRPLLPSENITAQQG-----NMKAL---QEQLDLQKKVLQAT 864
+ +S + S+IS+ H P ++ +T G N KAL E + L+K++ +
Sbjct: 2502 NLRRSQQAQDTSVISE-HTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLK 2560
Query: 865 QEAQEQLLLCKQKEVEQQTGLS 886
Q+ EQL+ K + + LS
Sbjct: 2561 QQ-NEQLIKQKNELLSNNQHLS 2581
Score = 32.3 bits (72), Expect = 6.3
Identities = 34/159 (21%), Positives = 75/159 (47%), Gaps = 18/159 (11%)
Query: 2457 SIEKPRTASTETPRRLTPVPGSLQEAFIKRKKSFME---RSHQR---QKEIRN-KIHVSE 2509
+I+K R +E +L+ + L+ + K ++ E HQ +K++ + VSE
Sbjct: 1789 TIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSE 1848
Query: 2510 NSQIKTVKEKPSISSSVSRLKGVNKVRASFPEDRKTTQALRHQRGLRLYNQLAEVKQQKE 2569
Q+K + S++ S ++ +N + + ++ + LR + ++++ +
Sbjct: 1849 MEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQL 1908
Query: 2570 EKTKQEAYAQN----------RARAKEFHKKTLEKLRAK 2598
+++ QE A++ R +KE HK+T++KLR K
Sbjct: 1909 KESLQETKARDLEIQQELKTARMLSKE-HKETVDKLREK 1946
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 89.4 bits (220), Expect = 4e-17
Identities = 386/2000 (19%), Positives = 789/2000 (39%), Gaps = 264/2000 (13%)
Query: 31 KLRLLQVREQERDIALQIREDIKQ--RRNQQFTRLAEELRAEWEESQTQKIQNLE-KLYL 87
K +L ++ ++ ++ L++ + +++++ +L E++ + E ++ K + E +++
Sbjct: 1308 KAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHA 1367
Query: 88 ASLRSMGE-------GHRQAKENEPDLDALAQRAAERKR-----KADLRHKEALKVQKNQ 135
SL+ E G +E +P LD L + ++++ L KEA + K Q
Sbjct: 1368 ESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAA-LTKIQ 1426
Query: 136 KEILLKQ---KTWHIKARKEALLVEKERSAKITSLPPPPPTLFENIEVKRISAVKTNSST 192
EI+ ++ K H + +A KE +I L E E+K+ S
Sbjct: 1427 TEIIEQEDLIKALHTQLEMQA----KEHDERIKQLQ------VELCEMKQKPEEIGEESR 1476
Query: 193 YHHLHTFVNRETDTKRPDARLAAEEEAKRLEELQKQAAQER--MERFEKAHVRGFQAMKK 250
++ K A ++ +E K + LQ++ + R +ER K+ ++
Sbjct: 1477 -------AKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKS----LADVES 1525
Query: 251 IHLAQNQEK--LMKELKQLQQEDLARRRQTVAQMPPQLVELPYKRSEMKEDWQRELEFAF 308
AQN+EK ++ L LQ+E R + + +M L+E S E + LE
Sbjct: 1526 QVSAQNKEKDTVLGRLALLQEE----RDKLITEMDRSLLE-NQSLSSSCESLKLALEGLT 1580
Query: 309 EDMYNADRKVKGNLILHLEPEPLPTVTNQIQDEELDLSMEQENLGAAEDLPVTEAEICSS 368
ED ++++ L+ + T + Q++ +L E E L + + EAE
Sbjct: 1581 EDKEKLVKEIES-----LKSSKIAEST-EWQEKHKELQKEYEILLQSYENVSNEAE---- 1630
Query: 369 ETDVPLVMKTQQIPSKVLFKKLLNKIRSQKSLWTIKSMSEDESEMITTVSEIESKAPTVE 428
+ V++ + + L+ KL + ++K T K + E E EM ++ A + +
Sbjct: 1631 --RIQHVVEAVRQEKQELYGKLRSTEANKKE--TEKQLQEAEQEMEEMKEKMRKFAKSKQ 1686
Query: 429 SGTIASKERTLSSGQEQVVESDTLTIE---SGPLASEDKPLSCGTNSGKEQEINET-LPI 484
+ +E E+D L E +G A E +N+ ++E+ +
Sbjct: 1687 QKILELEE-----------ENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEY 1735
Query: 485 TTVAQSSVLLHPQEAAARIRMSARQKQIMEIEEQKQKQLELLEQIEQQKLRLE--TDCFR 542
T+++ L ++ + + + QI E KQ LE E+ + Q E T
Sbjct: 1736 ETLSKKFQSLMSEKDSLSEEVQDLKHQI-EGNVSKQANLEATEKHDNQTNVTEEGTQSIP 1794
Query: 543 AQLEEEKR--KKTQPT---GVGIAPASCPVISDEDSHRQMIRNYQHQL------------ 585
+ EE+ T+PT V A ++ P +S + S I NY Q+
Sbjct: 1795 GETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEE 1854
Query: 586 -LQQNRLHRQSVETARKQLLEYQTMLKGRCP----SVSAPSLITDSVISVPSWKSE-RPT 639
Q+N+ Q++E + LL + G V+ +L+ + S ++ + T
Sbjct: 1855 EKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKET 1914
Query: 640 AISEHWDQGQRL-----KLSPNKYQPIQPIQTSKLEQDHFQVARQNHFP-------QRQV 687
A E D +RL +L+ + Q + ++++ + + +N ++Q
Sbjct: 1915 AEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQ 1974
Query: 688 ETTETLRASDILTNQALESQEHLRQFSQTETQQRDYKLVPKDSETLSRALSHDRQLISQD 747
E + + + LE + ++ ++ ++ + + K+ + + L D +
Sbjct: 1975 LVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEK 2034
Query: 748 ARKISETFGATTFQSLESQQLFSENSENISYHL-------TEPSSFVPLVPQHSFSSLPV 800
+ T A F ESQ+ EN++ + E +SF L+ + V
Sbjct: 2035 ISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARV 2094
Query: 801 KVESGKIQEPFSAMSKSTVSTSHSIISQMHDRPLLPSENITAQQGNMKALQEQLDLQKKV 860
++ K+++ + +S S + R E ++ NM+ + L +K
Sbjct: 2095 LADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVH 2154
Query: 861 LQATQEAQEQLLLCKQKEVEQQ--------TGLSVF---LPLVTPDSSALLPSAKADLGR 909
L+ T + L K KEV+Q T L+ F + + D ++ AK +
Sbjct: 2155 LEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERK 2214
Query: 910 IQESSPTKNN-IAVSSDHHVISQLQDKRLSLSQPILSQQNNFKFLQEQLNIQKDSLQARR 968
++ +K I + D+ S L+D+ +S + + N L+ I + Q
Sbjct: 2215 FSDAIQSKEEEIRLKEDN--CSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEV 2272
Query: 969 EAQEVLYVHKQSELDRRVCSEQAEPSFPFQVAQHTFTSLPSADTKSGKIQEQHSS----- 1023
+ Q+ + Q E ++ + S+ E + +Q+ L S + KS K Q S
Sbjct: 2273 QLQQKVCDTLQGE-NKELLSQLEETRHLYHSSQNELAKLES-ELKSLKDQLTDLSNSLEK 2330
Query: 1024 -KSEKG-----LVSCQSDIPISQDGSLSFLQQFLPLHDSLKL---LQEQLTKQRD---TL 1071
K +KG + ++DI Q+ S+ Q L S +L L E++ + +L
Sbjct: 2331 CKEQKGNLEGIIRQQEADI---QNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISL 2387
Query: 1072 QARHEAQVELLLHRQRDLGDSKSGLVSSSSSPVVVQHSVASQASAKAEPRR---IQELYL 1128
+ E +++ + R D + + + S ++ V + + KA + ++ L
Sbjct: 2388 LSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKT 2447
Query: 1129 SEKENVGPSCHL------IIPTFQDKSLSFPQHSLAQQENLTILQEQSQIQRVILGAKEG 1182
+KEN+ L + D+ + ++ +L+I+ E+ Q+ +
Sbjct: 2448 IKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNK 2507
Query: 1183 TQEFVHTESELEKRISSEQTGTSSSLSQVDESERFQECISIKSDSTIPLSHPKIPRCQER 1242
+E + ++SE + L Q E + I+IK L ++ + +E
Sbjct: 2508 LKEEIRGLRSHMDDLNSENAKLDAELIQYRED--LNQVITIKDSQQKQLLEVQLQQNKE- 2564
Query: 1243 LLRVSQHMLPLQDNLEEHQAWLDTEKEAFHFSQKTQENTSSEQTGSSSFIPQLVQLSFTS 1302
+ L++ L+E + + + +F+ Q+ +++ S E I QL + T+
Sbjct: 2565 ---LENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTR-QVTA 2620
Query: 1303 LASAESGTILEPLFTESESKIFSSHLQIPQLQDRLLRISQLIQPQQDNLKALQEQL-ATQ 1361
L + E + H Q+ ++ + R+S L Q + L+E+L Q
Sbjct: 2621 L--------------QEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQ 2666
Query: 1362 REAI-ILARQEAREELLLHQSEWEGRISPEQVDTSSLPLVPQHSFASLPLNESERNQEPC 1420
+EA + E + + L + I + +T+ + A L + E Q+
Sbjct: 2667 KEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETA------EERVAELARDLVEMEQKLL 2720
Query: 1421 SINSDN------IVSSGHS-------------EIPTLPDGL-LGLSHLVLPQQDNLIALE 1460
+ +N I S G S E+ L L L ++ L+ E
Sbjct: 2721 MVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRE 2780
Query: 1461 -EHLHAQTDFLPSIEKTQKELVLSKPCKFEEKVSSEHFIQSHHGDLQALQQQLDTQKKAI 1519
+ L ++T F S+ T++ + ++ +S + + L+ Q+ + KA+
Sbjct: 2781 RDALLSETAF--SMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAM 2838
Query: 1520 RSIQEVQEELLLQRLSELEK-RVSSEQVCSSSFVSQVPVADSERTQKSFPTKSNDTLPSS 1578
S+Q ++ L +ELEK R S E S+ A+ + +K+ + ND
Sbjct: 2839 ASLQNERDHL----WNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDR-DRL 2893
Query: 1579 HREIPRLQDRLLSLSKPILPQQDNMTAQLDAQREVMYSYEKPQEEL---SLNKQRKLNKS 1635
+E+ LQ + L +++ I + + AQL ++ +++ QEEL +L+ Q +L++
Sbjct: 2894 LKELKNLQQQYLQINQEI-TELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQL 2952
Query: 1636 -------ESAEHTIPSLFL----PKETEHSFIPLPFAEAKPKST-CELYSSQNEHAAPPS 1683
E E + +L K+ + S + E + S+ + Q + A P
Sbjct: 2953 RMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPE 3012
Query: 1684 NPVIPGFQDRLLSFSQSVLTQ-QDNLG--LQKQLDLQREVLHYSQKAQEKLLVQRQTA-L 1739
P L+ ++ + TQ D+L QK+L +Q+ ++SQ +EK + Q
Sbjct: 3013 TSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDT 3072
Query: 1740 QQQIQKHEETLKDFFKDSQISKPTVENDLKTQKMGQLR-DWFPNT-QDLAG----NDQEN 1793
Q ++++++ D + +E ++ + G L D P Q+ G +D E
Sbjct: 3073 SQSLRENQQHYGDLLNHCAV----LEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEE 3128
Query: 1794 IRHADRNNSD-DNHLASEDTSAKQSGEHLEKDLGRRSSKPPVAKVKCGLDLNQHELSAIQ 1852
+R ++ S+ L + + + LE++ +R + L + + ++ ++
Sbjct: 3129 LREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQR------VAAENALSVAEEQIRRLE 3182
Query: 1853 EVESPAIGRTSILGKPGIYE 1872
E + RT I+G G E
Sbjct: 3183 HSEWDS-SRTPIIGSCGTQE 3201
Score = 82.8 bits (203), Expect = 4e-15
Identities = 437/2445 (17%), Positives = 889/2445 (36%), Gaps = 404/2445 (16%)
Query: 258 EKLMKELKQLQQEDLARRRQTVAQMPPQLVELPYKRSE---MKEDWQRELEFAFEDMYNA 314
E+L+ ELK D+ R++ Q + ++ K ++ K + + + Y
Sbjct: 58 EQLVVELK-----DIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIE 112
Query: 315 DRKVKGNLILHLEP---EPLPTVTNQIQDEELDLSMEQENLGAAEDLPVT-EAEICSSET 370
+ K +G +L EP E L +EE+++ + L E+L T +A++ ++
Sbjct: 113 EMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQA 172
Query: 371 DVPLVMKTQQIPSKVLFKKLLNKIRSQKSLWTIKSMSEDESEMITTVSEIESKAPTVESG 430
+ P T+ + +K +++ E I+T+ S+ ++
Sbjct: 173 EQPAQSSTEM-----------------EEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAA 215
Query: 431 TIASKERTLSSGQEQVVESDTLTIESGPLASEDKPLSCGTNSGKEQEINETLPITTVAQS 490
+QVV E+ ED+ L T + E E+ + L V Q
Sbjct: 216 -------------QQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKL---RVLQR 259
Query: 491 SVLLHPQEAAARIRMSARQKQIMEIEEQKQKQLELLEQIEQQKLRLETDCFRAQLE---E 547
+ H + R ++ +Q + EQ+ ++L Q + Q++ E + R +E E
Sbjct: 260 KLEEHEESLVGRAQVVDLLQQELTAAEQRN---QILSQ-QLQQMEAEHNTLRNTVETERE 315
Query: 548 EKRKKTQPTGVGIAPASCPVISDEDSHRQMIRNYQHQLLQQNRLHRQSVETARKQLLEYQ 607
E + + + +A + ++ ++ ++ Q L + +K E +
Sbjct: 316 ESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEME 375
Query: 608 TMLKGRCPSVSAPSLITDSVISVPSWKSERPTAISEHWDQGQRLKLSPNKYQPIQPIQTS 667
T ++S+ E +A DQ +L N+ Q +Q QT
Sbjct: 376 EK--------------TSHILSLQKTGQELQSACDALKDQNSKLLQDKNE-QAVQSAQTI 420
Query: 668 KLEQDHFQVARQNHFPQRQVETTETLRASDILTNQALESQEHLRQFSQTETQQRDYKLVP 727
+ +D Q ++ S L L+ E Q S + + V
Sbjct: 421 QQLEDQLQ--------------QKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVT 466
Query: 728 KDSETLSRALSHDRQLISQDARKISETFGATTFQSLESQQLFSENSENISYHLTEPSSFV 787
+++ S ++++ + K GA S+E ++L +EN E +S +T
Sbjct: 467 EEN-----IASLQKRVVELENEK-----GALLLSSIELEELKAEN-EKLSSQIT------ 509
Query: 788 PLVPQHSFSSLPVKVESGKIQEPFSAMSKSTVSTSHSIISQMHDRPLLPSENITAQQGNM 847
L Q+ +V I + + S S + ++ + + ++ M
Sbjct: 510 LLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQ---KHKELSVLLLEM 566
Query: 848 KALQEQLDLQKKVLQATQEAQEQLLLCKQKEVEQQTG-------LSVFL-------PLVT 893
K QE++ K LQ + + + QKE++Q G + VFL PL+
Sbjct: 567 KEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLM- 625
Query: 894 PDSSALLPSAKADLGRIQESSPTKNNIAVSS---DHHVISQLQDKRLS------------ 938
P+ + LP+ + + + S T I+++ + Q DK LS
Sbjct: 626 PNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDE 685
Query: 939 ---LSQPILSQQNNFKFLQE--QLNIQKDSLQARREAQEVLYVHKQSELDRRVCSEQAE- 992
L IL + NF QE + N+ + + + Q + K ++ + + +E
Sbjct: 686 LERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEE 745
Query: 993 -PSFPFQVAQHTFTSLPSADTKSGKIQEQHSSKSEKGLVSCQSDIPISQDGSLSFLQQFL 1051
QV + + + A K ++ + + + Q+ + D L+ L
Sbjct: 746 RDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQT----AHDNLLTEQIHSL 801
Query: 1052 PLHDSLKLLQ-EQLTKQRDTLQARHEAQVELLLHRQRDLGDSKSGLVSSSSSPVVVQHSV 1110
+ K ++ E L + D +Q + Q L+ Q L + +S ++ + + V
Sbjct: 802 SIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKV 861
Query: 1111 ASQASA----KAEPRRIQELYLSEKENVGPSCHLIIPTFQDKSLSFPQHSLAQQENLTIL 1166
+ A + E ++ +L L +K +V + T ++K + S + E + L
Sbjct: 862 EELSQALSQKELEITKMDQLLLEKKRDV----ETLQQTIEEKDQQVTEISFSMTEKMVQL 917
Query: 1167 QEQSQIQRVILGAKEGTQEFVHTESELEKRISSEQTGTSSSLSQVDESERFQECISIKSD 1226
E+ V + + + E +K E SS L Q + E
Sbjct: 918 NEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQ-----NYDEMSPAGQI 972
Query: 1227 STIPLSHPKIPRCQERLLRVSQHMLPLQDNLEEHQAWLDTEKEAFHFSQKTQENTSSEQT 1286
S L H + LL+ + + QA L KE + +E ++ +
Sbjct: 973 SKEELQH------EFDLLKKEN-----EQRKRKLQAALINRKELLQRVSRLEEELANLKD 1021
Query: 1287 GSSSFIPQLVQLSFTSLASAESGTILEPLFTESESKIFSSHLQIPQLQDRLLRISQLIQP 1346
S IP L+ E G + E + E+K +S + Q+ + + Q I
Sbjct: 1022 ESKKEIP---------LSETERGEVEE----DKENKEYSEKCVTSKCQEIEIYLKQTISE 1068
Query: 1347 QQDNL----KALQEQLATQREAIILARQEAREELLLHQSEWEGRISPEQVDTSSLPLVPQ 1402
++ L K L+E+LA + + L +Q + + +I Q + S + Q
Sbjct: 1069 KEVELQHIRKDLEEKLAAEEQFQALVKQMNQT-----LQDKTNQIDLLQAEISENQAIIQ 1123
Query: 1403 HSFASLPLNESERNQEPCSINSDNIVSSGHSEIPTLPDGLLGLSHLVLPQQDNLIALEEH 1462
S N + + ++ + +V S P H ++ ++ALE+
Sbjct: 1124 KLITS---NTDASDGDSVALVKETVVIS--------PPCTGSSEHWKPELEEKILALEKE 1172
Query: 1463 LHAQTDFLPSIEKTQKELVLSKPCKFEEKVSSEHFIQSHHGDLQALQQQLDTQKKAIRSI 1522
L T ++ +L K + E + E ++ D LQ+Q D Q K +I
Sbjct: 1173 KEQLQKKLQE-ALTSRKAILKKAQEKERHLREE--LKQQKDDYNRLQEQFDEQSKENENI 1229
Query: 1523 QEVQEELLLQRLSELEKRVSS---EQVCSSSFVSQVPVADSERTQKSFPTKSNDTLPS-- 1577
+ +L +Q ++ ++ S ++ CSS+ + P+ + + P ++ P
Sbjct: 1230 GDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWP 1289
Query: 1578 SHRE----------IPRLQDRLLSLSKPILPQQ---DNMTAQLDAQREVMYSYEKPQEEL 1624
SH E + +++ +L + + + + T++L + E ++ ++ +
Sbjct: 1290 SHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQ 1349
Query: 1625 SLNKQRKLNKSESAEHTIPSLFLPKETEHSFIPLP----FAEAKPK--STCELYSSQNEH 1678
L + S AE + + L ++ E S + + E +PK +L S + E
Sbjct: 1350 GLEIESLKTVSHEAE--VHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEED 1407
Query: 1679 AAPPSNPVIPGFQDRLLSFSQSVLTQQDNLGLQKQLDLQREVLHYSQKAQEKLLVQRQTA 1738
+ + LS ++ LT+ +Q E++ QE L+ T
Sbjct: 1408 VS---------YLSGQLSEKEAALTK-----------IQTEIIE-----QEDLIKALHTQ 1442
Query: 1739 LQQQIQKHEETLKDFFKDSQISKPTVENDLKTQKMGQLRDWFPNTQDLAGNDQENIRHAD 1798
L+ Q ++H+E +K Q+ E K +++G+ Q + Q +
Sbjct: 1443 LEMQAKEHDERIK------QLQVELCEMKQKPEEIGEES---RAKQQIQRKLQAALISRK 1493
Query: 1799 RNNSDDNHLASEDTSAKQSGEHLEKDLGRRSSKPPVAKVKCGLDLNQHELSAIQEVESPA 1858
++ L E + A+ + E L K L S ++SA + +
Sbjct: 1494 EALKENKSLQEELSLARGTIERLTKSLADVES----------------QVSAQNKEKDTV 1537
Query: 1859 IGRTSILGKPGIYEDRDPLRVSISR---EQSFFGSPLAHDPFSCLQLVGQENVCGDDYDE 1915
+GR ++L E+RD L + R E S SC L +D ++
Sbjct: 1538 LGRLALL-----QEERDKLITEMDRSLLENQSLSS-------SCESLKLALEGLTEDKEK 1585
Query: 1916 AVKLKESVVENHAVLSYAVEEEHAYLGPTVKPDDKAKTLSYEPLSSATVSTGSLLS---Y 1972
VK ES+ + S +E+H L + + + SYE +S+ ++
Sbjct: 1586 LVKEIESLKSSKIAESTEWQEKHKEL----QKEYEILLQSYENVSNEAERIQHVVEAVRQ 1641
Query: 1973 ENTDL--SLTDPESFSEHMDDSKQESTTSKEEETNIISSIVPSTQD-IYQRQNSSD-VHK 2028
E +L L E+ + + QE+ EE + S Q I + + +D +
Sbjct: 1642 EKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRA 1701
Query: 2029 SLLPAVDETTCGHTHFQQMIDKYINEANLIPEKTDLQELEHIFPNLHHQLFKPLEPHPDF 2088
+ PA D K E L + +ELE + + L K +
Sbjct: 1702 EVHPAGDTA------------KECMETLLSSNASMKEELERVKME-YETLSKKFQ----- 1743
Query: 2089 DLSSSSSGISPDNRDFYQRSDSSSESHCATGLSKSTVYFTALRRTSMHSSLNTSPNQQPD 2148
L S +S + +D + + + S ++L +
Sbjct: 1744 SLMSEKDSLSEEVQDLKHQIEGN---------------------VSKQANLEATEKHDNQ 1782
Query: 2149 TNLAHVGAHSFATEN------IIGGSEQCFEQLQPEYS-----SQEESQHADLPSIFS-- 2195
TN+ G S E + C E + S S++ S H ++ +
Sbjct: 1783 TNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQI 1842
Query: 2196 IEARDSSQGMKNQNYPSEEHTEILQNKKKIVHFQLSI--GNLSSVYSSSDEANVFD-QLN 2252
+ ++ G++ + ++E ++ L+N+K + Q+S G L + + N+ + Q+
Sbjct: 1843 DQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQ 1902
Query: 2253 VQHSTPCGSNSSECSTKHQLESRKESMGFEELSKRGVVTMLQSQGLIEDN--KNETCRVL 2310
+ S + K LE R + E G + I++ ++E +
Sbjct: 1903 EELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLK 1962
Query: 2311 DINPQVEETDSRLCVRTVEMGTSIQAPYSLTTQNEKYFENSAETDIPKITKKLSQLGESE 2370
++EE +L ++ + I+ Y Q + E ++ ++ + L + +
Sbjct: 1963 KCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQK-EPGNKSHAKELQELLKEKQQEV 2021
Query: 2371 LFASSGSFSLQSSIPVWETETGHGIMEEPELTLISTTDTSIAEMDFANLTLEEKSENEAK 2430
Q I +E L S +++ L + E+ K
Sbjct: 2022 KQLQKDCIRYQEKI---------SALERTVKALEFVQTESQKDLEITKENLAQAVEHRKK 2072
Query: 2431 CFFQVSEFLPLVSATEASDYPAVSE-LSIEKPRTASTET------------PRRLTPVPG 2477
+++ F L+ T++ +++ L ++K ++ E+ RRL
Sbjct: 2073 AQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLE---- 2128
Query: 2478 SLQEAFIKRKKSFMER--SHQRQK----EIRNKIHVSENSQIKTVKE-KPSISSSVSRLK 2530
+E +K KK+ E+ + +R+K E +I V+ N + K V++ + ++ S+V++L
Sbjct: 2129 QAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLA 2188
Query: 2531 GVNKVRASFPEDRKTT--QALRHQRGLRLYNQLAEVKQQKEEKTK 2573
K +S +DR +A + +R + ++ Q KEE+ +
Sbjct: 2189 AFTKSMSSLQDDRDRVIDEAKKWER------KFSDAIQSKEEEIR 2227
Score = 77.8 bits (190), Expect = 1e-13
Identities = 379/2049 (18%), Positives = 752/2049 (36%), Gaps = 346/2049 (16%)
Query: 16 NEEAFILKEDYERRRKLRLLQVREQERDIALQIREDIKQRRN------------QQFTRL 63
NE + LK++Y+ + E + + L +E+ +++R Q+ +RL
Sbjct: 953 NEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRL 1012
Query: 64 AEEL-----------------RAEWEESQ----------TQKIQNLEKLYLASLRSMGEG 96
EEL R E EE + T K Q +E +YL S E
Sbjct: 1013 EEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIE-IYLKQTISEKEV 1071
Query: 97 HRQ--AKENEPDLDALAQRAAERKRKADLRHKEALKVQKNQKEILLKQKTWH--IKARKE 152
Q K+ E L A Q A K+ + ++ Q EI Q I + +
Sbjct: 1072 ELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTD 1131
Query: 153 ALLVEKERSAKITSLPPPPPT-LFENIEVKRISAVKTNSSTYHHLHTFVNRETDTKRPDA 211
A + K T + PP T E+ + + + L + +++
Sbjct: 1132 ASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAIL 1191
Query: 212 RLAAEEEAKRLEELQKQ-----AAQERMERFEKAHVRGFQAMKKIHLAQNQEKLMKELKQ 266
+ A E+E EEL++Q QE+ + K + ++++ + Q +E + +L
Sbjct: 1192 KKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQI-QVRESIDGKLPS 1250
Query: 267 LQQEDLARR----RQTVAQMPPQLVELPYKRSEMKEDWQRELEFAFEDMYNADRKVKGNL 322
Q++ + + + Q P S + DW E +A G
Sbjct: 1251 TDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSE-------DASALQGGTS 1303
Query: 323 ILHLEPEPLPTVTNQIQDEELDLSMEQENLGAAEDLPVTEAEICSSETDVPLVMKTQQIP 382
+ ++ + +++ E S E +E++ + +I ++ +KT
Sbjct: 1304 VAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIE-SLKTVSHE 1362
Query: 383 SKVLFKKLLNKIRSQK----SLWTIKSMSEDESEMITTVSEIESKAPTVESGTIASKERT 438
++V + L K+ S + L ++ + E+ +S+ E + SG ++ KE
Sbjct: 1363 AEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYL-SGQLSEKEAA 1421
Query: 439 LSSGQEQVVESDTL--------------------TIESGPLASEDKPLSCGTNSGKEQEI 478
L+ Q +++E + L ++ + KP G S +Q+I
Sbjct: 1422 LTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQI 1481
Query: 479 NETLPITTVAQSSVL-----LHPQEAAARIRMSARQKQIMEIEEQ-------KQKQLELL 526
L +++ L L + + AR + K + ++E Q K L L
Sbjct: 1482 QRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRL 1541
Query: 527 EQIEQQKLRLETDCFRAQLEEEKRKKTQPTGVGIAPASCPVISDEDSHRQMIRNYQHQLL 586
+++++ +L T+ R+ LE + + + + A + D++ + I + + +
Sbjct: 1542 ALLQEERDKLITEMDRSLLENQSLSSSCES---LKLALEGLTEDKEKLVKEIESLKSSKI 1598
Query: 587 QQNRLHRQSVETARKQLLEYQTMLKGRCPSVSAPSLITDSVISVPSWKSERPTAISEHWD 646
++ ++ + +K EY+ +L+ + I V +V K E
Sbjct: 1599 AESTEWQEKHKELQK---EYEILLQSYENVSNEAERIQHVVEAVRQEKQEL--------- 1646
Query: 647 QGQRLKLSPNKYQPIQPIQTSKLEQDHFQVARQNHFPQRQVETTETLRASDILT------ 700
G+ NK + + +Q ++ E + + + +Q + E +D L
Sbjct: 1647 YGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPA 1706
Query: 701 -NQALESQEHLRQFSQTETQQRDYKLVPKDSETLSR---ALSHDRQLISQDARKISETFG 756
+ A E E L S + + + + V + ETLS+ +L ++ +S++ + +
Sbjct: 1707 GDTAKECMETL--LSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDL----- 1759
Query: 757 ATTFQSLESQQLFSENSENISYHLTEPSSFVPLVPQHSFSSLPVKVESGKIQEPFSAMSK 816
Q+ S+ + TE V + S+P G+ +E S
Sbjct: 1760 --------KHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIP-----GETEEQDSLSMS 1806
Query: 817 STVSTSHSIISQMHDRPLLPSENITAQQGNMKALQEQLDLQKKVLQATQEAQEQLLLCKQ 876
+ + S S+ S P + S++ ++ LQ+ L++++ +E Q+ +
Sbjct: 1807 TRPTCSESVPSAKSANPAV-SKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQT 1865
Query: 877 KEVEQQTGLS---------VFLPLVTPDSSALLPSAKADLGRIQESSPTKNNIAVSSDHH 927
E E+ T LS L + L + +L R+ + T +
Sbjct: 1866 LENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEER 1925
Query: 928 VISQLQDKRLSLS---QPILSQQNNFKFLQEQL-NIQKDSLQARREAQEVLYVHKQSELD 983
+++QL + S+ Q + Q + L+ ++ N++K + E Q++ V ++++++
Sbjct: 1926 LMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQL--VKEKTKVE 1983
Query: 984 RRVCSEQAEPSFPFQVAQHTFTSLPSADTKSGKIQEQHSSKSEKGLVSCQSDIPISQDGS 1043
+ E E + A + G + H+ + ++ L Q ++ Q
Sbjct: 1984 SEIRKEYLE-------------KIQGAQKEPG--NKSHAKELQELLKEKQQEVKQLQKDC 2028
Query: 1044 LSFLQQFLPLHDSLKLLQEQLTKQRDTLQARHEAQVELLLHR---QRDLGDSKSGLVSSS 1100
+ + ++ L ++K L+ T+ + L+ E + + HR Q +L K L +
Sbjct: 2029 IRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQ 2088
Query: 1101 SSPVVV--------------QHSVASQASAKAE--PRRI---QELYLSEKENVGPSCHLI 1141
S V + SV SQ K E RR+ +E +L EK+N+
Sbjct: 2089 SEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNM------- 2141
Query: 1142 IPTFQDKSLSFPQHSLAQQENL-----TILQEQSQIQRVILGAKEGTQEFVHTESELEKR 1196
Q+K + + + +E + T+ ++ ++Q++ +E V + K
Sbjct: 2142 ----QEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQL----QENLDSTVTQLAAFTKS 2193
Query: 1197 ISSEQTGTSSSLSQVDESER-FQECISIKSDSTIPLSHPKIPRCQERLLRVSQHMLPLQD 1255
+SS Q + + + ER F + I K + I L +++L ++S HM L+
Sbjct: 2194 MSSLQDDRDRVIDEAKKWERKFSDAIQSKEEE-IRLKEDNCSVLKDQLRQMSIHMEELKI 2252
Query: 1256 NLE--EH--QAW-------------------------LDTEKEAFHFSQKTQENTSSEQT 1286
N+ EH Q W L +E H +Q + ++
Sbjct: 2253 NISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLES 2312
Query: 1287 GSSSFIPQLVQLSFTSLASAESGTILEPLFTESESKIFSSHLQIPQLQDRLLRISQLIQP 1346
S QL LS + E LE + + E+ I +S QL+ L +L
Sbjct: 2313 ELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSR 2372
Query: 1347 QQDNLKALQEQ----LATQREAIILARQEARE---------ELLLHQSEWEGRISPEQ-- 1391
+ + +++ L+ + EAI +A E R+ E LL Q E E + E+
Sbjct: 2373 LHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENK 2432
Query: 1392 --VDTS-----SLPLVPQH-------------SFASL---------PLNESERNQEPCSI 1422
VD + +L + + S +SL + E +
Sbjct: 2433 KAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIIL 2492
Query: 1423 NSDNIVSSGHSEIPTLPDGLLGL-SHLVLPQQDN------LIALEEHLHAQTDFLPSIEK 1475
D ++ +E L + + GL SH+ +N LI E L+ S +K
Sbjct: 2493 EKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQK 2552
Query: 1476 TQKELVLSKPCKFEEKVSSEHFIQSHHGDLQALQQQLDTQKKAIRSIQEVQEELLLQRLS 1535
E+ L + + E K + + L++ + + RS +QEE
Sbjct: 2553 QLLEVQLQQNKELENKYAKLE---------EKLKESEEANEDLRRSFNALQEE-----KQ 2598
Query: 1536 ELEKRVSSEQVCSSSFVSQVPVADSERTQKSFPTKSNDTLPSSHREIPRLQDRLLSLSKP 1595
+L K + S +V S QV E T + + L E+ RL S K
Sbjct: 2599 DLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQ----LKVKEEEVHRLSALFSSSQKR 2654
Query: 1596 ILPQQDNMT-AQLDAQREVMYSYEKPQEELS-LNKQRKL--NKSESAEHTIPSLFLPKET 1651
I ++ + Q +A ++V +K ++EL L+ + N++E+AE + L
Sbjct: 2655 IAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVE 2714
Query: 1652 EHSFIPLPFAEAK---------PKSTCELYSSQNEHAAPPSNPVIPGFQDRLLSFSQSVL 1702
+ + E K +S L +S+ +HA + + + L +Q L
Sbjct: 2715 MEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSR-DHANEELDELKRKYDASLKELAQ--L 2771
Query: 1703 TQQDNLGLQKQLDLQREVLHYSQKAQEKLLVQRQTALQQQIQKHEETLKDFFKDSQISKP 1762
+Q L ++ L E +E L + QQ + K E+ L +S
Sbjct: 2772 KEQGLLNRERDA-LLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLL-------HLSSQ 2823
Query: 1763 TVENDLKTQKMGQLRDWFPNTQDLAGNDQENIRHAD----RNNSDDNHLASEDTSAKQSG 1818
++ + Q + N +D N+ E R ++ R+ + + +E S K++
Sbjct: 2824 LEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAM 2883
Query: 1819 EHLEKDLGR 1827
L+ D R
Sbjct: 2884 SSLQNDRDR 2892
Score = 67.8 bits (164), Expect = 1e-10
Identities = 364/1965 (18%), Positives = 734/1965 (37%), Gaps = 259/1965 (13%)
Query: 27 ERRRKLRLLQVREQERDIALQIREDI----------KQRRNQQFTRLAEELRAEWE---- 72
E ++KLR+LQ + +E + +L R + ++RNQ ++ +++ AE
Sbjct: 249 EMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRN 308
Query: 73 ----ESQTQKIQNLEKLYLA-------------SLRSMGEGHRQAKENEPDLDALAQRAA 115
E + KI LEK+ L + + E QA + + +L++ A
Sbjct: 309 TVETEREESKIL-LEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELES-RYSAL 366
Query: 116 ERKRKADLRHKEA--LKVQKNQKEILLKQKTWHIKARKEALLVEKERSAKITSLPPPPPT 173
E+K KA++ K + L +QK +E L+ +K + LL +K A ++
Sbjct: 367 EQKHKAEMEEKTSHILSLQKTGQE--LQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLE 424
Query: 174 LFENIEVKRISAVKTNSSTYHHLHTFVNRETDTKRPDARLAAEEEA----KRLEELQKQA 229
+ K IS H D + EE KR+ EL+ +
Sbjct: 425 DQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEK 484
Query: 230 AQERMERFE----KAHVRGFQAMKKIHLAQNQE-KLMKELKQLQQEDLARRRQTVAQMPP 284
+ E KA + + AQN+ + +E+ ++ D+A +R + A+
Sbjct: 485 GALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESG 544
Query: 285 Q-LVELPYKRSEMKEDWQRELEFAFEDMYNADRKVKGNLILHLEPEPLPTVTNQIQDEEL 343
Q ++E + + +EL +M A ++ L L L+ + +++ D++
Sbjct: 545 QDVLENTFSQKH------KELSVLLLEMKEAQEEI-AFLKLQLQGKRAEEADHEVLDQKE 597
Query: 344 DLSMEQENLG----------AAEDLPVTEAEICSSETDVPLVMKTQQIPSKVLFKKLLNK 393
ME E + +D P+ E E+ +P V K Q S + +
Sbjct: 598 MKQMEGEGIAPIKMKVFLEDTGQDFPLMPNE----ESSLPAVEKEQA--STEHQSRTSEE 651
Query: 394 IRSQKSLWTIKSMSEDESEMITTVSEI-ESKAPTVESGTIASKERTLSSGQEQVVESDTL 452
I + +KS +D + ++ V +I + +E E L+ + Q + L
Sbjct: 652 ISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNL 711
Query: 453 TIESGPLASEDKPLSCGTNSGKEQEINETLPITTVAQSSVLLHPQ----EAAARIRMSAR 508
+ A E L+ K+ N + T +++ L Q +R +
Sbjct: 712 DEK----AKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVK 767
Query: 509 QKQIMEIEEQKQKQLELLEQIEQQKLRLETDCFRAQLEEEKRKKTQPTGVGIAPASCPVI 568
Q ++ E ++Q++L+ Q L T+ + E K K + + +
Sbjct: 768 QLEMNLAEAERQRRLDYESQTAHDNLL--TEQIHSLSIEAKSKDVKIEVLQNELDDVQLQ 825
Query: 569 SDEDSHRQMIRNYQHQLLQQNRLHRQSVETARKQLLEY----QTMLKGRCPSVSAPSLIT 624
E S +IR+ Q QL + + E R + Q + + L+
Sbjct: 826 FSEQS--TLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLL 883
Query: 625 DSVISVPSW------KSERPTAISEHWDQGQRLKLSPNKYQPIQPIQTSKLEQDHFQVAR 678
+ V + K ++ T IS + + ++L+ K+ I+T K + + ++R
Sbjct: 884 EKKRDVETLQQTIEEKDQQVTEISFSMTE-KMVQLNEEKFSLGVEIKTLKEQLN--LLSR 940
Query: 679 QNHFPQRQVETTETLRASDILTNQALESQEHLRQFSQTETQQRDYKLVPKDSETLSR--- 735
+ QVE + + Q + Q S+ E Q ++ L+ K++E R
Sbjct: 941 AEEAKKEQVEEDNEVSSG---LKQNYDEMSPAGQISKEELQH-EFDLLKKENEQRKRKLQ 996
Query: 736 -ALSHDRQLISQDAR----------------KISETFGATTFQSLE----SQQLFSENSE 774
AL + ++L+ + +R +SET + E S++ + +
Sbjct: 997 AALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQ 1056
Query: 775 NISYHLTEPSSFVPLVPQHSFSSLPVKVESGKIQEPFSAMSKSTVSTSHSIISQMHDRPL 834
I +L + S + QH L K+ + +E F A+ K T +Q+ L
Sbjct: 1057 EIEIYLKQTISEKEVELQHIRKDLEEKLAA---EEQFQALVKQMNQTLQDKTNQID---L 1110
Query: 835 LPSENITAQQGNMKALQEQLDLQKKVLQATQEAQEQLLLCKQKEVEQQTGLSVFLPLVTP 894
L +E + E + +K++ + +A + + KE V P T
Sbjct: 1111 LQAE-----------ISENQAIIQKLITSNTDASDGDSVALVKETV------VISPPCTG 1153
Query: 895 DSSALLPSAKAD---LGRIQESSPTKNNIAVSSDHHVISQLQDKRLSLSQPILSQQNNFK 951
S P + L + +E K A++S ++ + Q+K L + + Q++++
Sbjct: 1154 SSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYN 1213
Query: 952 FLQEQLNIQKDSLQARREAQEVLYVHKQSELDRRVCSEQAEPSFPFQVAQHTFTSLPSAD 1011
LQEQ + Q +E + + +Q ++ R E + P Q + +S P +
Sbjct: 1214 RLQEQFDEQS------KENENIGDQLRQLQIQVR---ESIDGKLPSTDQQESCSSTPGLE 1264
Query: 1012 TKSGKIQEQHSSKSEKGLVSCQSDIPISQDGSLSFLQQFLPLHDSLKLLQEQLTKQRDTL 1071
K EQH ++ C S+D S L S+ ++ QL + +
Sbjct: 1265 EPLFKATEQHHTQPVLESNLCPDWPSHSEDASA------LQGGTSVAQIKAQLKE----I 1314
Query: 1072 QARHEAQVELLLHRQRDLGDSKSGLVSSSSSPVVVQHSVASQASAKAEPRRIQELYLSEK 1131
+A +VEL L + + S L S +Q + Q L +
Sbjct: 1315 EAE---KVELEL----KVSSTTSELTKKSEEVFQLQEQINKQG-----------LEIESL 1356
Query: 1132 ENVGPSCHLIIPTFQDKSLSFPQHSLAQQENLTILQEQ-SQIQRVILGAKEGTQEFVHTE 1190
+ V + + Q K L Q +A E+L LQ + ++Q++I +E
Sbjct: 1357 KTVSHEAEVHAESLQQK-LESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQL 1415
Query: 1191 SELEKRISSEQTGTSSSLSQVDESERFQECISIKSDSTIPLSHPKIPRCQERLLRVSQHM 1250
SE E ++ QT + E + + D I ++ +++ + +
Sbjct: 1416 SEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEES 1475
Query: 1251 LPLQDNLEEHQAWLDTEKEAFHFSQKTQENTSSEQTGSSSFIPQLVQL-SFTSLASAESG 1309
Q + QA L + KEA ++ QE S + L + S S + E
Sbjct: 1476 RAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKD 1535
Query: 1310 TILE--PLFTESESKIFSSHLQIPQLQDRLLRISQLIQPQQDNLKALQEQLATQREAIIL 1367
T+L L E K+ + DR L +Q + ++LK E L +E ++
Sbjct: 1536 TVLGRLALLQEERDKLITE-------MDRSLLENQSLSSSCESLKLALEGLTEDKEKLVK 1588
Query: 1368 ARQEAREELLLHQSEWEGRISPEQVDTSSLPLVPQHSFASLPLNESERNQEPCSINSDNI 1427
+ + + +EW+ + Q + L S+ ++ NE+ER Q ++
Sbjct: 1589 EIESLKSSKIAESTEWQEKHKELQKEYEIL----LQSYENVS-NEAERIQ--------HV 1635
Query: 1428 VSSGHSEIPTLPDGLLGLSHLVLPQQDNLIALEEHLHAQTDFLPSIEKTQKELVLS---- 1483
V + E L L + L E+ + + + K++++ +L
Sbjct: 1636 VEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEE 1695
Query: 1484 --------KPCKFEEKVSSEHFIQSHHG---DLQALQQQLDTQKKAIRSIQEVQEELL-- 1530
P K E + S+ +L+ ++ + +T K +S+ ++ L
Sbjct: 1696 NDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEE 1755
Query: 1531 LQRLS-ELEKRVSSEQVCSSSFVSQVPVADSERTQKSFP--TKSNDTL-----PSSHREI 1582
+Q L ++E VS + ++ +E +S P T+ D+L P+ +
Sbjct: 1756 VQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESV 1815
Query: 1583 PRLQDRLLSLSKPILPQQD--NMTAQLDAQREVMYSYEKPQEELSLNKQRKLNKSESAEH 1640
P + ++SK + N Q+D +E + E EE NK+ E+ ++
Sbjct: 1816 PSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLE---EEKQKNKEFS-QTLENEKN 1871
Query: 1641 TIPSLFLPKETEHSFI-----PLPFAEAKPKSTCELYSSQNEHAAPPSNPVIPGFQDRLL 1695
T+ S K+ E + + + + + E A + + ++L
Sbjct: 1872 TLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLA 1931
Query: 1696 SFSQSVLTQ-QDNLGLQKQLDLQREVLHYSQKAQEKLLVQRQTALQQQIQKHEETLKDFF 1754
+ S+ QD Q + +L + +K +L ++Q ++++ + E K++
Sbjct: 1932 ELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYL 1991
Query: 1755 KDSQISKPTVENDLKTQKMGQLRDWFPNTQDLAGNDQENIRHADRNNSDDNHLASEDTSA 1814
+ Q ++ N +++ +L Q++ ++ IR+ ++ ++ + + + +
Sbjct: 1992 EKIQGAQKEPGNKSHAKELQELLK--EKQQEVKQLQKDCIRYQEKISALERTVKALEFVQ 2049
Query: 1815 KQSGEHLE---KDLG-----RRSSKPPVAKVKCGLDLNQHELSAI 1851
+S + LE ++L R+ ++ +A K LD Q E + +
Sbjct: 2050 TESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARV 2094
Score = 61.2 bits (147), Expect = 1e-08
Identities = 368/1914 (19%), Positives = 731/1914 (38%), Gaps = 337/1914 (17%)
Query: 27 ERRRKLRLLQVREQERDIALQIRED----IKQRRNQQFTRLAEELRAEWEESQTQKIQNL 82
E+ + LQ QE A +D + Q +N+Q + A+ ++ + E+ QK + +
Sbjct: 376 EKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQ-QLEDQLQQKSKEI 434
Query: 83 EKLYLASLRSMGEGHRQAKENE-PDLDALAQRAAERKRKADLRHKEALKVQKNQKEILLK 141
+ R + H A + PD+ +A + A L+ K ++++ + +LL
Sbjct: 435 SQFLN---RLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQ-KRVVELENEKGALLLS 490
Query: 142 Q-KTWHIKARKEALLVEKERSAKITSLPPPPPTLFENIEVKRISAV----KTNSSTYHHL 196
+ +KA E L S++IT L T + EV IS V K +SS
Sbjct: 491 SIELEELKAENEKL------SSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESG 544
Query: 197 HTFVNRETDTKRPDARLAAEEEAKRLEELQKQAAQERMERFEKAHVRGFQAMKKIHLAQN 256
+ K + + E ++E Q++ A F K ++G +A + H +
Sbjct: 545 QDVLENTFSQKHKELSVLLLE----MKEAQEEIA------FLKLQLQGKRAEEADHEVLD 594
Query: 257 QEKLMKELKQLQQEDLARRRQTV---------AQMPPQLVELPYKRSEM-----KEDWQR 302
Q KE+KQ++ E +A + V MP + LP E +
Sbjct: 595 Q----KEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSE 650
Query: 303 ELEFAFEDMYNADRKVKGNLILHLEPE-------PLPTVTNQIQDEELDLSMEQENLGAA 355
E+ + K G+ L P+ L + +QI + EL+ QE
Sbjct: 651 EISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKN 710
Query: 356 EDLPVTEAEICS-------------SETDVPLVMKTQQIPSKVLFKKLLNKIRSQ-KSLW 401
D E + S L + Q+ S+V ++ ++R+Q K L
Sbjct: 711 LDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLE 770
Query: 402 TIKSMSEDE---------------SEMITTVSEIESKAPTVESGTIASKERTLSSGQEQV 446
+ +E + +E I ++S IE+K+ V+ I + L Q Q
Sbjct: 771 MNLAEAERQRRLDYESQTAHDNLLTEQIHSLS-IEAKSKDVK---IEVLQNELDDVQLQF 826
Query: 447 VESDTL--TIESGPLASEDKPLSCGTN----SGKEQEINETLP---ITTVAQSSVLLHPQ 497
E TL +++S E + L S K +E+++ L + +LL +
Sbjct: 827 SEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKK 886
Query: 498 EAAARIRMSARQKQIMEIEEQKQKQLELLEQIEQQKLRL--ETDCFRAQLE----EEKRK 551
++ + +K ++ E E + Q+ ++K L E + QL E+ K
Sbjct: 887 RDVETLQQTIEEKD-QQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAK 945
Query: 552 KTQPTGVGIAPASCPVISDEDSHRQMI--RNYQHQ---LLQQNRLHRQSVETA---RKQL 603
K Q + DE S I QH+ L ++N ++ ++ A RK+L
Sbjct: 946 KEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKEL 1005
Query: 604 LEYQTMLKGRCPSVSAPSLITDSVISVPSWKSERPTAISEHWDQGQRLKLSPNKYQPI-- 661
L+ + L+ ++ +S +P ++ER + ++ K +K Q I
Sbjct: 1006 LQRVSRLEEELANLK-----DESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEI 1060
Query: 662 ---QPIQTSKLEQDHFQ------VARQNHFPQRQVETTETLRAS----DILTNQALESQE 708
Q I ++E H + +A + F + +TL+ D+L + E+Q
Sbjct: 1061 YLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQA 1120
Query: 709 HLRQFSQTETQQRDYKLVPKDSETL------SRALSHDRQLISQDA---RKISETFGATT 759
+++ + T D V ET+ + + H + + + K E
Sbjct: 1121 IIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKL 1180
Query: 760 FQSLESQQLFSENSENISYHLTEPSSFVPLVPQHSFSSLPVKVESGKIQEPFSAMSKSTV 819
++L S++ + ++ HL E K + ++QE F SK
Sbjct: 1181 QEALTSRKAILKKAQEKERHLREELK-------------QQKDDYNRLQEQFDEQSKE-- 1225
Query: 820 STSHSIISQMHDRPLLPSENITAQ---QGNMKALQEQLDLQKKVLQATQEAQEQLLLCKQ 876
+ +I Q+ + E+I + ++ L++ + +AT++ Q +L
Sbjct: 1226 --NENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVL--- 1280
Query: 877 KEVEQQTGLSVFLPLVTPDSSAL-----LPSAKADLGRIQESSPTKNNIAVSSDHHVISQ 931
++ L P + D+SAL + KA L I E+ + + VSS S+
Sbjct: 1281 -----ESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEI-EAEKVELELKVSS---TTSE 1331
Query: 932 LQDKRLSLSQPILSQQNNFKFLQEQLNIQKDSLQARREAQEVLYVHKQSELDRRVCSEQA 991
L K + Q LQEQ+N Q +++ + VH +S L +++ S Q
Sbjct: 1332 LTKKSEEVFQ-----------LQEQINKQGLEIESLKTVSHEAEVHAES-LQQKLESSQ- 1378
Query: 992 EPSFPFQVA--QHTFTSLPSADTKSGKIQEQHS---------SKSEKGLVSCQSDIPISQ 1040
Q+A +H P D I ++ S+ E L Q++I I Q
Sbjct: 1379 -----LQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEI-IEQ 1432
Query: 1041 DGSLSFLQQFLPL----HDS-LKLLQEQLTKQR-------DTLQARHEAQVEL---LLHR 1085
+ + L L + HD +K LQ +L + + + +A+ + Q +L L+ R
Sbjct: 1433 EDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISR 1492
Query: 1086 QRDLGDSKSGLVSSSSSPVVVQHSVASQASAKAEPRRIQELYLSEKENVGPSCHLIIPTF 1145
+ L ++KS S + ++ S A +++ + EK+ V L+
Sbjct: 1493 KEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNK----EKDTVLGRLALLQEE- 1547
Query: 1146 QDKSLSFPQHSLAQQENLTILQEQSQIQRVILGAKEGTQEFVHTESELEKRISSEQTGTS 1205
+DK ++ SL + ++L+ E ++ A EG E + +L K I S ++
Sbjct: 1548 RDKLITEMDRSLLENQSLSSSCESLKL------ALEGLTE---DKEKLVKEIESLKS--- 1595
Query: 1206 SSLSQVDESERFQECISIKSDSTIPLSHPKIPRCQERLLRVSQHMLPLQDNLEEHQAWLD 1265
S++ ES +QE H ++ + E LL+ +++ + ++ +
Sbjct: 1596 ---SKIAESTEWQE------------KHKELQKEYEILLQSYENVSNEAERIQHVVEAVR 1640
Query: 1266 TEKEAFHFSQKTQENTSSE---QTGSSSFIPQLVQLSFTSLASAESGTILEPLFTESE-- 1320
EK+ + ++ E E Q + + ++ A ++ ILE L E++
Sbjct: 1641 QEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILE-LEEENDRL 1699
Query: 1321 -SKIFSSHLQIPQLQDRLLRISQLIQPQQDNLKALQEQLATQREAIILARQEAREELLLH 1379
+++ + + + LL + ++ + + +K E L+ + ++++ + EE+
Sbjct: 1700 RAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDL 1759
Query: 1380 QSEWEGRISPE----------------QVDTSSLP-LVPQHSFASLPLNESERNQEPCSI 1422
+ + EG +S + + T S+P + S+ + P +
Sbjct: 1760 KHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAK 1819
Query: 1423 NSDNIVSSGHSEIPTLPDGLLGLSHLVLPQQDNLIALEEHLHAQTDFLPSIEKTQKELVL 1482
+++ VS S + + L + L ++ + LEE +F ++E +K +L
Sbjct: 1820 SANPAVSKDFSSHDEINNYLQQIDQL----KERIAGLEEEKQKNKEFSQTLEN-EKNTLL 1874
Query: 1483 SKPCKFEEKVSSEHFIQSHHGDLQALQQQLDTQKKAIRSIQEVQEELLLQRLSELEKRVS 1542
S+ K +Q + L QQ+ + + ++E EE +LE+R+
Sbjct: 1875 SQ---ISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEE----EKDDLEERLM 1927
Query: 1543 SEQVCSSSFVSQV--PVADSERTQKSFPTKSNDTLPSSHREIPRLQDRLLSLSKPILPQQ 1600
++ + + V D++ N+ L S + + + L + ++ ++
Sbjct: 1928 NQLAELNGSIGNYCQDVTDAQI--------KNELLESEMKNLKKCVSELEEEKQQLVKEK 1979
Query: 1601 DNMTAQL---------DAQREV-MYSYEKPQEELSLNKQRKLNKSESA----EHTIPSLF 1646
+ +++ AQ+E S+ K +EL KQ+++ + + + I +L
Sbjct: 1980 TKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISAL- 2038
Query: 1647 LPKETEHSFIPLPFAEAKPKSTCELYSSQNEHAAPPSNPVIPGFQDRLLSF--------S 1698
E + L F + + + E+ A Q L SF S
Sbjct: 2039 -----ERTVKALEFVQTESQKDLEITKENLAQAVEHRKKA----QAELASFKVLLDDTQS 2089
Query: 1699 QSVLTQQDNLGLQKQLDLQREVLHYSQKAQEKLLVQRQTALQQQIQKHEETLKD 1752
++ DNL L+K+L +E + K +++ L +R L+Q +KH + K+
Sbjct: 2090 EAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERR---LEQAEEKHLKEKKN 2140
Score = 47.8 bits (112), Expect = 1e-04
Identities = 108/544 (19%), Positives = 201/544 (36%), Gaps = 97/544 (17%)
Query: 1240 QERLLRVSQHMLPLQDNLEEHQAWLDTEKEAFHFSQKTQEN--------TSSEQTGSSSF 1291
QERL Q ++ L+D + + L + EA +K +N ++ T + +
Sbjct: 51 QERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKY 110
Query: 1292 IPQL---------------VQLSFTSLASAESGTILEPL---FTESESKIFSSHLQIPQL 1333
I ++ QLS +S E +E + E E I + Q+ Q
Sbjct: 111 IEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQA 170
Query: 1334 Q-----------DRLLRISQLIQPQQDNLKALQEQLATQREAIILARQEARE-------E 1375
Q + + + Q +Q +++ + LQ QL +Q +A A+Q RE +
Sbjct: 171 QAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQL-SQTQAEQAAQQVVREKDARFETQ 229
Query: 1376 LLLHQSEWEGRISPEQVDTS---------------SLPLVPQHSFASLPLNESERNQEPC 1420
+ LH+ E ++ V+T LV + L E ++
Sbjct: 230 VRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRN 289
Query: 1421 SINSDNI--VSSGHSEIPTLPDGLLGLSHLVLPQQDNLIA--------LEEHLHAQTDFL 1470
I S + + + H+ + + S ++L + + +A L+E +H +
Sbjct: 290 QILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQF 349
Query: 1471 PSIEKTQKE-------LVLSKPCKFEEKVSSEHFIQSHHGDLQALQQQLDTQKKAIRSIQ 1523
+ Q E L + EEK S +Q +LQ+ L Q + +
Sbjct: 350 EQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDK 409
Query: 1524 EVQEELLLQRLSELEKRVSSEQVCSSSFVSQVPVADSE-RTQKSFPTKSND-TLPSSHRE 1581
Q Q + +LE ++ + S F++++P+ E +Q SFP N+ T +
Sbjct: 410 NEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEEN 469
Query: 1582 IPRLQDRLLSL--SKPILPQQDNMTAQLDAQREVMYSY-------------EKPQEELS- 1625
I LQ R++ L K L +L A+ E + S ++ E+S
Sbjct: 470 IASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISI 529
Query: 1626 --LNKQRKLNKSESAEHTIPSLFLPKETEHSFIPLPFAEAKPKSTCELYSSQNEHAAPPS 1683
+ +R + ES + + + F K E S + L EA+ + Q + A
Sbjct: 530 VDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEAD 589
Query: 1684 NPVI 1687
+ V+
Sbjct: 590 HEVL 593
Score = 32.7 bits (73), Expect = 4.8
Identities = 85/442 (19%), Positives = 167/442 (37%), Gaps = 67/442 (15%)
Query: 1312 LEPLFTESESKIFSSHLQIPQLQDRLLRISQLIQPQQDNLKALQEQLATQREAIILARQE 1371
L+P + F++ Q +Q+RL QL+ +D ++ QL + EA+ R+
Sbjct: 30 LDPELHQESDMEFNNTTQ-EDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKA 88
Query: 1372 AREELLLHQSEWEGRISP-----EQVDTSS---LPLVPQHSFASLPLNESERNQEPCSIN 1423
A ++ + + +++ E++ LP PQ S L ++ +E I
Sbjct: 89 ADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQ-SEEQLSKHDKSSTEEEMEIE 147
Query: 1424 SDNIVSSGHSEIPTLPDGLLGLSHLVLPQQ-----DNLIALEEHLHAQTDFLPSI----- 1473
E+ + L + P Q + + +++ L + +F+ ++
Sbjct: 148 KIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLS 207
Query: 1474 ----EKTQKELVLSKPCKFEEKVSSEHFIQSHHGDLQALQQQLDTQ---KKAIRSIQEVQ 1526
E+ +++V K +FE +V + H +L L Q D + ++ +R +Q
Sbjct: 208 QTQAEQAAQQVVREKDARFETQV------RLHEDELLQLVTQADVETEMQQKLRVLQRKL 261
Query: 1527 EE-------------LLLQRLSELEKRVSSEQVCSSSFVSQVPVADSER-TQKSFPTKSN 1572
EE LL Q L+ E+R Q+ S ++ R T ++ +S
Sbjct: 262 EEHEESLVGRAQVVDLLQQELTAAEQR---NQILSQQLQQMEAEHNTLRNTVETEREESK 318
Query: 1573 DTLPSSHREIPRLQDRLLSLSKPI--LPQQDNMTAQLDAQREVMYSYEKPQEELSLNKQR 1630
L E+ + +L + + L +Q Q A+ E YS +L ++
Sbjct: 319 ILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYS--------ALEQKH 370
Query: 1631 KLNKSESAEHTIPSLFLPKETEHSFIPLPFAEAKPKSTCELYSSQNEHAAPPSNPVIPGF 1690
K E H + +E + + +A +L +NE A S I
Sbjct: 371 KAEMEEKTSHILSLQKTGQELQSA------CDALKDQNSKLLQDKNEQAV-QSAQTIQQL 423
Query: 1691 QDRLLSFSQSVLTQQDNLGLQK 1712
+D+L S+ + + L LQ+
Sbjct: 424 EDQLQQKSKEISQFLNRLPLQQ 445
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 83.6 bits (205), Expect = 2e-15
Identities = 316/1741 (18%), Positives = 693/1741 (39%), Gaps = 313/1741 (17%)
Query: 12 RLSPNEEAFILKEDYERRRKLRLLQVREQ-----ERDIALQIREDIKQRRNQQFTRLAEE 66
RLS ++E + + + +L L ++ Q E++ L+I +D QFTR EE
Sbjct: 60 RLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEE 119
Query: 67 LRAEWEE-SQTQKIQNLEKLYLA-SLRSMGEGHRQAKENEPDLDALAQRAAERKRKADLR 124
L AE + +T + + E YL ++ + E +++ + +L Q + + +D+
Sbjct: 120 LEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGEL----QLKLDELQASDVS 175
Query: 125 HKEALKVQKNQKEILLKQKTW---HIKARKEALL-VEKERSAKITSLPPPPPTLFENIE- 179
K K + +KE+L Q TW +K + + LL + +E+ +I L E +
Sbjct: 176 VKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSR 235
Query: 180 -VKRISAVKT-NSSTYHHLHTFVNRETDTKRPDARLAAEEEAK-----RLEELQKQAAQE 232
++++ +KT N H+ + + + K A + + + +L L K AA +
Sbjct: 236 LEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADD 295
Query: 233 RMERFEKAHVRGFQAMKKIHLAQNQEKLMKELKQLQ---QEDLARRRQTVAQMPPQLVEL 289
+ + +A++++H KL+KE + Q+ L Q+ QM +++E
Sbjct: 296 SEAKSNEL----TRAVEELH------KLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLE- 344
Query: 290 PYKRSEMKEDWQRELEFAFEDMYNADRKVKGNLILHLEPEPL-PTVTN------------ 336
K + ++ELE A D+ +A ++ KG ++ E + PT
Sbjct: 345 --KIGRL----EKELENA-NDLLSATKR-KGAILSEEELAAMSPTAAAVAKIVKPGMKLT 396
Query: 337 -------QIQDEELDLSMEQENLGAAEDLPVTEAEICSSETDVPLVMKTQQIPSKVLFKK 389
+ QD+ L +E + + D V E E P++ + ++ +
Sbjct: 397 ELYNAYVETQDQLLLEKLENKRINKYLDEIVKEV-----EAKAPILKRQREEYERAQKAV 451
Query: 390 LLNKIRSQKSLWTIKSMSE--DESEMITTVSEIESKAPTVESGTIASKERTLSSGQEQVV 447
++ ++++ I+ + E D++ ++V E +++ ++ ++ + R L E+
Sbjct: 452 ASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEAR 511
Query: 448 ESDTL---TIESGPLASEDKPLS----CGTNSGKEQEINETLPI-------TTVAQSSVL 493
+ + + S ++S + +S N + Q+ N+ L + T +
Sbjct: 512 GNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQET 571
Query: 494 LHPQEAAARIRMSARQKQIMEIEEQKQKQLELLEQIEQQKLRLETDCFRAQLEE------ 547
+ ++++ + ++ ++ + +Q Q++L++ I +Q+ D +R L +
Sbjct: 572 TSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQR-----DMYRILLSQTTGVAI 626
Query: 548 ---------------EKRKKTQPTGVGIAPASCPVISDEDS---------HRQMIRNYQH 583
KR T T PA PVI ++ +++ NY+
Sbjct: 627 PLHASSLDDVSLASTPKRPSTSQT--VSTPAPVPVIESTEAIEAKAALKQLQEIFENYKK 684
Query: 584 QLLQQNRLHRQSVETARKQLLEYQTMLKGRCPSVSAPS----LITDSV------ISVPSW 633
+ + ++ + +E ++Q+ + ++ + S ++ D+V I+
Sbjct: 685 EKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHE 744
Query: 634 KSERPTAISEHWDQ-----GQRLKLSPNKYQPIQ-PIQTSKLEQDHFQVARQNHFPQRQV 687
++++ TA ++ +Q Q L+ + K + + K E++ +++ QR+
Sbjct: 745 RNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRES 804
Query: 688 ETTETLRASDILTNQALESQEHLRQFSQTETQQRDYKLVPKDSETLSRALSHDRQLISQD 747
E + +LTN L++ + + + S+TET+QR + E L +SH ++ + +
Sbjct: 805 LLAEQRGQNLLLTN--LQTIQGILERSETETKQR----LSSQIEKLEHEISHLKKKLENE 858
Query: 748 ARKISETFGATTFQSLES-QQLFSENSENISYH--LTEPSSFVPLVPQHSFSSLPVKVES 804
+ Q L++ +QL +E + +++ L + + QH S++ V+V S
Sbjct: 859 VEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQH-LSNMEVQVAS 917
Query: 805 GKIQEPFSAMSK---------STVSTSHSIISQMHDRPLLPSENITAQQGNMKALQEQLD 855
Q S + + ++ + +R + N+ Q + +L+E L+
Sbjct: 918 QSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLN 977
Query: 856 LQKKVLQATQEAQEQLLLCKQKEVEQQTGLSVFLPLVTPDSSALLPSAKADLGRIQESSP 915
+K Q T+E ++ + + ++ E QT L L V + L +
Sbjct: 978 KEK---QVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKR----------- 1023
Query: 916 TKNNIAVSSDHHVISQLQDKRLSLSQPILSQQNNF-KFLQEQLNIQKDSLQARREAQE-- 972
I ++ + L + + S QN + LQ + QARR+ QE
Sbjct: 1024 -----------RAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQA 1072
Query: 973 VLYVHKQSELDRRVCSEQAEPSFPFQVAQHTFTSLPSADTKSGKIQEQHSSKSEKGLVSC 1032
+ V Q++ +R + A+ Q A+ + + S + E+ + K+E L+ C
Sbjct: 1073 KIAVEAQNKYERELMLHAADVE-ALQAAKEQVSKMASV----RQHLEETTQKAESQLLEC 1127
Query: 1033 QSDIPISQDGSLSFLQQFLPLHDSLKLLQEQLTKQRDTLQARHEAQVELLLHRQRDLGDS 1092
++ + ++L+++++K + + LLH Q +
Sbjct: 1128 KAS-----------------WEERERMLKDEVSK--CVCRCEDLEKQNRLLHDQIEKLSD 1168
Query: 1093 KSGLVSSSSSPVVVQHSVASQASAKAEPRRIQELYLSEKENVGPSCHLIIPTFQDKSLSF 1152
K +V+S V +V+ K++ + ++ L +E K ++
Sbjct: 1169 K--VVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRRE---------------KEIAE 1211
Query: 1153 PQHSLAQQENLTILQEQSQIQRVILGAKEGTQEFVHTESELEKRISSEQTGTSSSLSQVD 1212
+ +AQ E+L Q ++R + + Q+ ++ E E + T+ +++Q +
Sbjct: 1212 TRFEVAQVESLRYRQRVELLEREL----QELQDSLNAERE-------KVQVTAKTMAQHE 1260
Query: 1213 ESERFQECISIKSDSTIPLSHPK------IPRCQERLLRVSQHMLPLQD---NLEEHQAW 1263
E + E +++ ++ L K + + Q ++ ++ +LPLQ+ L E
Sbjct: 1261 ELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGM 1320
Query: 1264 LDTEKEAFH-------------FSQKTQENTS------SEQTGSSSFIPQL--------V 1296
L EK+ SQ+ +T SE+ + I QL
Sbjct: 1321 LQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKA 1380
Query: 1297 QLSFTSLASAESGTILEPL-------FTESESKIFSSHLQIPQLQDRLLRISQL------ 1343
+++ ++ + + +++ L TE E+ +I +Q+++ I+Q+
Sbjct: 1381 EIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRR 1440
Query: 1344 IQPQQDNLKALQEQLATQREAIILARQEAREELLLHQSEWEGRISPEQVDTSSLPLVPQH 1403
+ Q + LKA Q+++ E + + +E+ + Q E + + Q +T S L Q
Sbjct: 1441 YKTQYEELKAQQDKV---METSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQV 1497
Query: 1404 SFASLPLNESERNQEPCSINSDNIVSSGHSEIPTLPDGLLGLSHLVLPQQDNLIALEEHL 1463
L+E E + + S LS L QD EE L
Sbjct: 1498 ENLQKTLSEKETEARNLQEQTVQLQSE--------------LSRLRQDLQDR-TTQEEQL 1542
Query: 1464 HAQTDFLPSIEKTQKELVLSKP-----CKFEEKVSSEH-FIQSHHGDLQALQQQLDTQKK 1517
Q EKT+K +V +K +++++ E+ ++ +G L + +LD +
Sbjct: 1543 RQQ--ITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRIT 1600
Query: 1518 AIRSIQEVQEELLLQRLSELEKRVSSEQVCSSSFVSQVPVADSERTQKSFPTKSNDTLPS 1577
A++S E + L + L E ++R ++ ++VP + T K+ P + S
Sbjct: 1601 ALKSQYEGRISRLERELREHQERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGERGIAS 1660
Query: 1578 S 1578
+
Sbjct: 1661 T 1661
Score = 42.4 bits (98), Expect = 0.006
Identities = 111/534 (20%), Positives = 223/534 (41%), Gaps = 75/534 (14%)
Query: 1313 EPLFTESESKIFSSHLQIPQLQDRLLRISQLIQPQQDNLKALQEQLATQREAIILARQE- 1371
E ESE + F ++ Q+RL+ ++ Q +L+ E+L Q +A+ +E
Sbjct: 44 EKFKVESEQQYFEIEKRLSHSQERLVNETRECQ----SLRLELEKLNNQLKALTEKNKEL 99
Query: 1372 --AREELLLHQSEWEGRISPEQVDTSSLPLVPQHSFASLPLNESERNQEPCSINSDNIVS 1429
A++ + QS++ + E+++ L+ + S E E E ++ +
Sbjct: 100 EIAQDRNIAIQSQFTR--TKEELEAEKRDLIRTNERLS---QELEYLTEDVKRLNEKLKE 154
Query: 1430 SGHS--EIPTLPDGLLGLSHLVLPQQDNLIALEEHLHAQTDFLPSIEKTQK-ELVLSKPC 1486
S + E+ D L V ++ L +E LH+Q +L + KT+ EL+
Sbjct: 155 SNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGRE 214
Query: 1487 KFEEKVSSEHFIQSHHGDLQALQQQLDTQKKAIRSIQEVQEELLLQRLSELEKRVSSEQV 1546
K E + + +++ ++ L++Q++ K + +Q+ E+LL + E++ S E+
Sbjct: 215 KGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEK 274
Query: 1547 CSSSFVSQVPVADSERTQKSFPTKSNDTLPSSHREIPRLQDRLLSLSKPILPQQDNMTAQ 1606
+ + + +++ ++ ++ L + E+ +L +K I QD++
Sbjct: 275 FHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAI---QDHLL-- 329
Query: 1607 LDAQREVMYSYEKPQEELSLNKQRKLNKS-ESAEHTIPSL-----FLPKETEHSFIPLPF 1660
EV S ++ ++E+ L K +L K E+A + + L +E + P
Sbjct: 330 -----EVEQSKDQMEKEM-LEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAA 383
Query: 1661 AEAK----PKSTCELYSSQNEHAAPPSNPVIPGFQDRLLSFSQSVLTQQDNLGLQKQLD- 1715
A AK ELY++ E QD+LL L + +N + K LD
Sbjct: 384 AVAKIVKPGMKLTELYNAYVET------------QDQLL------LEKLENKRINKYLDE 425
Query: 1716 -------------LQREVLHYSQKAQEKLLVQRQTALQQQIQKHEETLKDFFKDSQISKP 1762
QRE +QKA L V+ + A+++ + E+T K + S + +
Sbjct: 426 IVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERD 485
Query: 1763 TVENDLKTQKMG-QLRDWFPNTQDLAGND---QENIRHADRNNSDD---NHLAS 1809
+++ + + Q+R ++ GN E + AD ++S + HL S
Sbjct: 486 NRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVS 539
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 81.6 bits (200), Expect = 9e-15
Identities = 215/1048 (20%), Positives = 420/1048 (40%), Gaps = 163/1048 (15%)
Query: 33 RLLQVREQERDIALQIREDIKQRRNQQFTRLAEELRAEWEESQTQKIQNLEKLYLASLRS 92
R +Q R+Q++D I T L E + E +I+ +EK L
Sbjct: 1382 RTVQKRQQQKDF-------IDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSE 1434
Query: 93 MGEGHRQAKENEPDLDALAQRAAERKRKADLRHKEALKVQKNQKEILLKQKTWHIKARKE 152
+ E R E E +L ++ K + L+ + + +E+ +A++
Sbjct: 1435 LREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEEL-------ERRAQET 1487
Query: 153 ALLVEKERSAKITSLPPPPPTLFENIEVKRISAVKTNSSTYHHLHTFVNRETDTKRPDAR 212
A+ + K ++ SL L E ++K+ +K +N+ K D +
Sbjct: 1488 AVNLVKA-DQQLRSLQADAKDL-EQHKIKQEEILKE-----------INKIVAAKDSDFQ 1534
Query: 213 LAAEEEAKRLEELQK-QAAQERMERFEKAHVRGFQAMKKIHLAQNQE--KLMKELKQLQQ 269
++++ K EELQK Q E ER E H++ + + + A+ E KL ++ QQ
Sbjct: 1535 CLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQ 1594
Query: 270 EDLARRRQTVAQMPPQLVELPYKRSEMKEDWQREL---EFAFEDMYNADRKVKGNLILHL 326
E RQ + +L L + K D Q L E + N R+VK L
Sbjct: 1595 EMAVLDRQ-LGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLL---- 1649
Query: 327 EPEPLPTVTNQIQDEELDLSMEQENLGAAE---DLPVTEAEICSSETDVPLVMKTQQIPS 383
EEL + N+ +E L + + EI E ++ +V++ Q
Sbjct: 1650 --------------EELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLR-QMSKH 1694
Query: 384 KVLFKKLLNKIRSQKSLWTIKSMSEDE--SEMITT-VSEIESKAPTVESGTIASKERTLS 440
K K +L+ ++ + + D+ SE+ T V+ +E K I+ +++
Sbjct: 1695 KTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEI 1754
Query: 441 SGQEQVVESDTLTIESGPLASEDKPL-SCGTNSGKEQE-INETLPI--TTVAQSSVLLHP 496
Q+Q++E D IE + +E + L SC KE+E + E I +AQ+ +L
Sbjct: 1755 EWQKQLLERDKREIER--MTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVL-- 1810
Query: 497 QEAAARIRMSARQKQIMEIEEQKQKQLELLEQIEQQKLRLETDCFRAQLE-EEKRKKTQP 555
AAA Q + ++E +K + L+Q+ + KL L D Q + +EKR+
Sbjct: 1811 --AAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAV-- 1866
Query: 556 TGVGIAPASCPVISDEDSHRQMIRNYQHQLLQQNRLHRQSVETARKQ--LLEYQTMLKGR 613
+S ++ + N Q L N + + T + Q LL QT L+
Sbjct: 1867 ----------------NSLQEELANVQDHL---NLAKQDLLHTTKHQDVLLSEQTRLQ-- 1905
Query: 614 CPSVSAPSLITDSVISVPSWKSERPTAISEHWDQGQRLKLSP-----NKYQPIQPIQTSK 668
+S + + K ++ + ++ +LKL + Q + + SK
Sbjct: 1906 -KDISEWANRFEDCQKEEETKQQQLQVLQNEIEE-NKLKLVQQEMMFQRLQKERESEESK 1963
Query: 669 LEQDHFQVARQNHFPQRQVETTETLRASDILTNQALESQEHLRQFSQTETQQRDYKLVPK 728
LE + Q H Q + E T+ D + ++ L ++E +R + E +
Sbjct: 1964 LETSKVTLKEQQH--QLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEE----------R 2011
Query: 729 DSETLSRALSHDRQLISQDARKISETFGATTFQSLESQQLFSENSENISYHLTEPSSFVP 788
E+L + LS ++ +S+ +++ E G E+ + ++ S + LTE
Sbjct: 2012 WCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKK--- 2068
Query: 789 LVPQHSFSSL--PVKVESGKI------QEPFSAMSKSTVSTSHSIISQMHDRPLLPSENI 840
+ +SL +K++ ++ Q+ ++ + ++T + H+R + +
Sbjct: 2069 --AEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKEL 2126
Query: 841 TAQQGNMKALQEQLDLQKKVLQATQEAQEQLLLCKQKEVEQ----QTGLSVFLPLVTPDS 896
Q L++Q+ QK + + E + + K + ++ L+ FLP + D
Sbjct: 2127 NQMQYEYTELKKQMANQKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADL 2186
Query: 897 SALL---PSAKADLGRIQESSPTKNNIAVSSDHHVISQLQDKRLSLSQPILSQQNNFKFL 953
A+L + + +L ++E+ P N + SQ+ I+ + + L
Sbjct: 2187 EAILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVH---------IMDEHWRGEAL 2237
Query: 954 QEQLNIQKDSLQAR------REAQEVLYVHKQSE------------LDRRVCSEQAEPSF 995
+E+L ++D L+A+ ++A+ ++ +Q+E L V S A+ +
Sbjct: 2238 REKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGELVTSTSADSAS 2297
Query: 996 PFQVAQHTFTSLPSADTKSGKIQEQHSS 1023
++Q S + D++ G+ QE+++S
Sbjct: 2298 SPSLSQ--LESSLTEDSQLGQNQEKNAS 2323
Score = 60.8 bits (146), Expect = 2e-08
Identities = 153/769 (19%), Positives = 307/769 (39%), Gaps = 121/769 (15%)
Query: 54 QRRNQQFTRLAEELRAEWEESQTQKIQNLEKLYLASLRSMGEGHRQAKENEPDLDALAQR 113
Q R + F R + E E +K+ E+L R + E Q K N+ +L +
Sbjct: 258 QDRQEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNK----SLKEE 313
Query: 114 AAERKRKADLRHKEALKVQKNQKEILLKQKT-------------------WHIKARKEAL 154
A +K+ E LK N K LLKQKT + I A+ E L
Sbjct: 314 AMLQKQSC-----EELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPL 368
Query: 155 LVEKERSAKITSLPPPPPTLFEN-------------------IEVKRISAVKTNSSTYHH 195
A+I P P + ++ +++K++ + + + +
Sbjct: 369 NYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMN 428
Query: 196 LHTFVNRETDTKRPDARLAAEEEAKRLEELQKQAAQERMERFEKAHVRGFQAMKKIHLAQ 255
L +T + + +++A + RL EL + +E+ E+ +R + K++ A
Sbjct: 429 LRGHTPLDTQLEDKEKKISAAQ--TRLSEL-----HDEIEKAEQQILRATEEFKQLEEAI 481
Query: 256 NQEKLMKELKQLQQEDLARRRQTVAQMPPQLVELPYKRSEMKEDWQ------RELEFAFE 309
+K+ + K L + L+ R Q V ++ + ++L + + K++ ++L+ A +
Sbjct: 482 QLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAID 541
Query: 310 DMYNADRKVKGNLILHLEPEPLPTVTNQIQDEELDLSMEQ-ENLGAAEDLPVTE-AEICS 367
+ + D K H++ + ++++LD+ +Q + L + D ++ A+
Sbjct: 542 SLDSKDPKHS-----HMKAQ------KSGKEQQLDIMNKQYQQLESRLDEILSRIAKETE 590
Query: 368 SETDVPLVMKTQQIPSKVLFKKLLNKIRS--QKSLWTIKSMSEDESEMITTVSEIESKAP 425
D+ + QI + KK L + S Q+ L TIK + + +
Sbjct: 591 EIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRD------ 644
Query: 426 TVESGTIASKERTLSSGQEQVVESDTLTIESGPLASEDKPLSCGTNSGKEQ-EINETLPI 484
KE L E E D L I + + K L+ ++ +EQ E+N +L
Sbjct: 645 --------EKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQ 696
Query: 485 TTVAQSSVLLHPQEAAARIRMSARQKQIMEIEEQKQKQLELLEQ------IEQQKLRLET 538
T Q + + E AR+ + + ++ E +K +L LEQ +E+++ L+
Sbjct: 697 T---QGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKN 753
Query: 539 DCFRAQLEEEKRKKTQPTGVGIAPASCPVISDEDSHRQMIRNYQHQLLQ-QNRLHRQSVE 597
+AQ EEK ++ + D + +Q ++++Q+ L + L R
Sbjct: 754 ALGKAQFSEEKEQENSELHAKLKHLQ----DDNNLLKQQLKDFQNHLNHVVDGLVRPEEV 809
Query: 598 TARKQLLEYQTMLKGRCPSVSAPS-LITDSVISVPSWKSERPTAISEHWDQGQRLKLSPN 656
AR L + L ++ +PS ++ S+ + SE W++ + ++
Sbjct: 810 AARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSE--ILARSKWERDE-AQVRER 866
Query: 657 KYQPIQPIQTSKLE--QDHFQVARQN------HFPQRQVETTETLRASDI-LTNQALESQ 707
K Q +Q KL Q+ F+ A + +F +RQ E ++I + L+S
Sbjct: 867 KLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSM 926
Query: 708 EHLRQFSQTETQQRDYKLVPKDSETLSRALSHDRQLISQDARKISETFG 756
E ++ + + Q+ D + L++ +++ +DA+ + FG
Sbjct: 927 EEIQGLTDLQLQEAD----EEKERILAQLRELEKKKKLEDAKSQEQVFG 971
Score = 58.9 bits (141), Expect = 6e-08
Identities = 157/833 (18%), Positives = 320/833 (38%), Gaps = 127/833 (15%)
Query: 912 ESSPTKNNIAVSSDHHVISQLQDKRLSLSQPILSQQNNFKFLQEQLNIQKDSLQARREAQ 971
ES T+ I S HH + D+ + + +L +++ + L + L +E
Sbjct: 1399 ESLMTELEIEKSLKHH--EDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKT 1456
Query: 972 EVLYVHKQSELDRRVCSEQAEPSFPFQVAQHTFTSLPSADTKSGKIQ------EQHSSKS 1025
+ V K ++ R + +++ + AQ T +L AD + +Q EQH K
Sbjct: 1457 KNA-VEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQ 1515
Query: 1026 EKGLVSCQSDIPISQDGSLSFLQQFLPLHDSLKLLQEQLT----KQRDTLQARHEAQVEL 1081
E+ L + ++ L + L+ LQ+ + + LQ E++V L
Sbjct: 1516 EEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEV-L 1574
Query: 1082 LLHRQRDLGDSKSGLVSSSSSPVVVQHSVA-----------SQASAKAEPRRIQELYLSE 1130
L ++ +L KS + S V+ + S AKA+ + + L L E
Sbjct: 1575 LQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQ--EALRLGE 1632
Query: 1131 KENVGPSCHLIIPTFQDKSLSFPQHSLAQQENLTILQEQSQIQRVILGAKEGTQEFVHTE 1190
E H+ + LSF + L N+ I + ++Q+ + QE E
Sbjct: 1633 TEVTEKCNHIREVKSLLEELSFQKGEL----NVQISERKTQLTLI-------KQEIEKEE 1681
Query: 1191 SELE---KRISSEQTGTSSSLSQVDESERFQECISIKSDSTIPLSHPKIPRCQERLLRVS 1247
L+ +++S +T + L + + + ++ D + ++ + Q +L
Sbjct: 1682 ENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVS----ELEKTQVAVLEEK 1737
Query: 1248 QHMLPLQDNLEEHQAWLDTEKEAFHFSQKTQENTSSEQTGSSSFIPQLVQ---------- 1297
+ LQ ++ + ++ +K+ ++ E ++E S + L +
Sbjct: 1738 LELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCD 1797
Query: 1298 -----LSFTS--LASAESGTILEPLFTESESKIFSSHLQIPQLQDRLLRISQLIQPQQDN 1350
L+ T LA+AE + +E +S + L + +LQ L ++++ ++
Sbjct: 1798 IWEKKLAQTKRVLAAAEENSKME------QSNLEKLELNVRKLQQELDQLNRDKLSLHND 1851
Query: 1351 LKALQEQLATQREAIILARQE----------AREELL---LHQ--------------SEW 1383
+ A+Q+QL +REA+ ++E A+++LL HQ SEW
Sbjct: 1852 ISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEW 1911
Query: 1384 EGR----------------ISPEQVDTSSLPLVPQHSFASLPLNESERNQEPCSINSDNI 1427
R + +++ + L LV Q E E + + +
Sbjct: 1912 ANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTL 1971
Query: 1428 VSSGHSEIPTLPDGLLGLSHL---VLPQQDNLIALEEHLHAQTDFLPSIEKTQKELVLSK 1484
H L D L + VL ++ + L+E ++ +T+++L +
Sbjct: 1972 KEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSERE 2031
Query: 1485 PCKFE---EKVSSEHFIQSHHGDLQALQQQ-LDTQKKAIRSIQEVQEELLLQRLSELEKR 1540
E E ++ + S D L+ Q L +KKA + + ++E L +QR S+LEK
Sbjct: 2032 QQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQR-SQLEKN 2090
Query: 1541 VSSEQVCSSSFVSQVP----VADSERTQKSFPTKSNDTLPSSHREIPRLQDRLLSLSKPI 1596
+ ++ +S ++ VA + K + + + E+ + L +
Sbjct: 2091 LLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQ 2150
Query: 1597 LPQQDNM-TAQLDAQREVMYSYEKPQE---ELSLNKQRKLNKSESAEHTIPSL 1645
+ D M T + + + E+ S + + EL + + L ++E+ E + SL
Sbjct: 2151 MEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELESL 2203
Score = 45.8 bits (107), Expect = 5e-04
Identities = 147/709 (20%), Positives = 259/709 (36%), Gaps = 149/709 (21%)
Query: 922 VSSDHHVISQLQDKRLSLSQPILSQQNNFKFLQEQLNIQKDS----------LQARRE-- 969
+S+ +S+L D+ Q IL FK L+E + ++K S L R +
Sbjct: 446 ISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLV 505
Query: 970 ---AQEVLYVHKQSELDRRVCSEQAEPSFPFQVAQHTFTSLPSADTKSGKIQEQHSSKSE 1026
QE L + Q E ++ + + + Q+A SL S D K ++ Q S K +
Sbjct: 506 NKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIA---IDSLDSKDPKHSHMKAQKSGKEQ 562
Query: 1027 KGLVSCQSDIPISQDGSLSFLQQFLPLHDSLKLLQEQLTKQRDTLQARHEAQVELLLHRQ 1086
Q DI +Q+ L L + ++ K+ + ++ E E +
Sbjct: 563 ------QLDI---------MNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAAN 607
Query: 1087 RDLGDSKSGLVSSSSSPVVVQHSVASQASAKAEPRRIQELYLSEKENVGPSCHLIIPTFQ 1146
L G++S + A+Q A+ E R++++ EKE +
Sbjct: 608 EALKKDLEGVISGLQEYLGTIKGQATQ--AQNECRKLRD----EKETL------------ 649
Query: 1147 DKSLSFPQHSLAQQENLTILQEQSQIQRVILGAKEGTQEFVHTESELEKRISSEQTGTSS 1206
Q + QE+ Q++ V + A+ +E ES L+ EQ ++
Sbjct: 650 ------------LQRLTEVEQERDQLEIVAMDAENMRKELAELESALQ-----EQHEVNA 692
Query: 1207 SLSQVDESERFQECISIKSDSTIPLSHPKIPRCQERLLRVSQHMLPLQDNLEEHQAWLDT 1266
SL Q +S + L+ L A +
Sbjct: 693 SLQQTQGD-------------------------------LSAYEAELEARLNLRDAEANQ 721
Query: 1267 EKEAFHFSQKTQENTSSEQTGSSSFIPQLVQLSFTSLASAESGTILEPLFTESESKIFSS 1326
KE +K T EQ+ + + + Q +L A+ E E +
Sbjct: 722 LKEEL---EKVTRLTQLEQSALQAELEKERQALKNALGKAQ-------FSEEKEQENSEL 771
Query: 1327 HLQIPQLQDRLLRISQLIQPQQDNLKALQEQLATQREAIILAR-QEAREELLLHQSEWEG 1385
H ++ LQD + Q ++ Q++L + + L E + AR E R +L L E
Sbjct: 772 HAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEE--VAARVDELRRKLKLGTGEMNI 829
Query: 1386 RISPEQVDTSSLPLVPQHSFASLPLNESERNQEPCSINSDNIVSSGHSEIPTLPDGLLGL 1445
SP V SL + + L ++ ER++ E + L
Sbjct: 830 H-SPSDVLGKSLADLQKQFSEILARSKWERDEAQV------------RERKLQEEMALQQ 876
Query: 1446 SHLVLPQQDNLIALEEHLHAQTDFLPSIEKTQKELVLSKPCKFEEKVSSEHFIQSHHGDL 1505
L Q++ A E L A+ +F +K Q E + ++ + H++Q + +
Sbjct: 877 EKLATGQEEFRQACERALEARMNF----DKRQHE------ARIQQMENEIHYLQENLKSM 926
Query: 1506 QALQQQLDTQKKAIRSIQEVQE--ELLLQRLSELEKRVSSEQVCSSSFVSQVPVADSERT 1563
+ +Q D Q +QE E E +L +L ELEK+ E S QV D E
Sbjct: 927 EEIQGLTDLQ------LQEADEEKERILAQLRELEKKKKLEDAKSQ---EQVFGLDKELK 977
Query: 1564 QKSFPTKSNDTLPSSHREIPRLQDRLLSLSKPILPQQDNMTAQL-DAQR 1611
+ ++D L ++ E+ +D+L SL ++ +L +A+R
Sbjct: 978 KLKKAVATSDKLATA--ELTIAKDQLKSLHGTVMKINQERAEELQEAER 1024
Score = 35.8 bits (81), Expect = 0.57
Identities = 83/377 (22%), Positives = 149/377 (39%), Gaps = 50/377 (13%)
Query: 22 LKEDYERRRKLRLLQVREQERDIALQIREDIKQRRNQQFTRLAEELRAEWEESQTQKIQN 81
L+E +E L+ Q + L+ R ++ R+ + +L EEL +K+
Sbjct: 684 LQEQHEVNASLQQTQGDLSAYEAELEARLNL---RDAEANQLKEEL---------EKVTR 731
Query: 82 LEKLYLASLRSMGEGHRQAKENEPDLDALAQRAAERKRKADLRHKEALKVQKNQKEILLK 141
L +L ++L++ E RQA +N AQ + E++++ H + +Q + LLK
Sbjct: 732 LTQLEQSALQAELEKERQALKNAL---GKAQFSEEKEQENSELHAKLKHLQDDNN--LLK 786
Query: 142 QKTW----HIKARKEALLVEKERSAKITSLPPPPPTLFENIEVKRISAVKTNS-----ST 192
Q+ H+ + L+ +E +A++ L + + S V S
Sbjct: 787 QQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQ 846
Query: 193 YHHLHTFVNRETDTKRPDARLAAEEEAKRLEELQ----------KQAAQERMERFEKAHV 242
+ + E D + R EE A + E+L ++A + RM ++ H
Sbjct: 847 FSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHE 906
Query: 243 RGFQAMK-KIHLAQNQEKLMKELKQLQQEDLARRRQTVAQMPPQLVELPYKR-------S 294
Q M+ +IH Q K M+E++ L L + ++ QL EL K+
Sbjct: 907 ARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQ 966
Query: 295 EMKEDWQRELEFAFEDMYNADRKVKGNLILHLEP-EPLPTVTNQIQDEELDLSMEQENLG 353
E +EL+ + + +D+ L + + + L +I E + E E
Sbjct: 967 EQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFS 1026
Query: 354 -----AAEDLPVTEAEI 365
AA DL EAEI
Sbjct: 1027 RKAAQAARDLTRAEAEI 1043
Score = 32.3 bits (72), Expect = 6.3
Identities = 95/495 (19%), Positives = 187/495 (37%), Gaps = 86/495 (17%)
Query: 1194 EKRISSEQTGTSSSLSQVDESER-----------FQECISIKSDSTIPLSHPKIPRCQER 1242
EK+IS+ QT S +++++E+ +E I +K S ++
Sbjct: 443 EKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAG---------KDL 493
Query: 1243 LLRVSQHMLPLQDNLEEHQAWLDTEKEAFHFSQKTQENTSSEQTGSSSFIPQLVQLSFTS 1302
L + L L + L + LD E + E E G I L Q++ S
Sbjct: 494 LYKQLSGRLQLVNKLRQEA--LDLELQ--------MEKQKQEIAGKQKEIKDL-QIAIDS 542
Query: 1303 LASAE-SGTILEPLFTESESKIFSSHLQIPQLQDRLLRISQLIQPQQDNLKALQEQLATQ 1361
L S + + ++ + E ++ + Q QL+ RL I I + + +K L+EQL
Sbjct: 543 LDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEG 602
Query: 1362 REAIILARQEAREELLLHQSEW----EGRISPEQVDTSSLPLVPQHSFASLPLNESERNQ 1417
+ A A ++ E ++ E+ +G+ + Q + L + L E ER+Q
Sbjct: 603 QIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQ 662
Query: 1418 -EPCSINSDNIVSSGHSEIPTLPDGLL---GLSHLVLPQQDNLIALEEHLHAQTDF---- 1469
E +++++N+ E+ L L ++ + Q +L A E L A+ +
Sbjct: 663 LEIVAMDAENM----RKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAE 718
Query: 1470 -------------LPSIEKTQKELVLSK----------PCKFEEKVSSEHFIQSHHGDLQ 1506
L +E++ + L K +F E+ E+ H L+
Sbjct: 719 ANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQEN--SELHAKLK 776
Query: 1507 ALQQQLDTQKKAIRSIQE---------VQEELLLQRLSELEKRV----SSEQVCSSSFVS 1553
LQ + K+ ++ Q V+ E + R+ EL +++ + S S V
Sbjct: 777 HLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVL 836
Query: 1554 QVPVADSERTQKSFPTKSNDTLPSSHREIPRLQDRLLSLSKPILPQQDNMTAQLDAQREV 1613
+AD ++ +S + +LQ+ + + + Q+ + E
Sbjct: 837 GKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEA 896
Query: 1614 MYSYEKPQEELSLNK 1628
+++K Q E + +
Sbjct: 897 RMNFDKRQHEARIQQ 911
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 81.3 bits (199), Expect = 1e-14
Identities = 343/1770 (19%), Positives = 694/1770 (39%), Gaps = 284/1770 (16%)
Query: 55 RRNQQFTRLAEELRAEWEESQT--QKIQNLEKLYLASL-RSMGEGHRQAKE--NEPDLDA 109
+R ++ R R ++ E T Q +Q +K L +S + R+ E E +D
Sbjct: 141 QRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREELQMDQ 200
Query: 110 LAQRAAERKRKADLRHKEALKVQKNQKEILLKQKTWHIKARKEAL--LVEKERSAKITSL 167
A++ + + A L K+ + LLKQ+ + + L L + E A++ +
Sbjct: 201 QAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTK 260
Query: 168 PPPPPTLFENIEVKRISAVKTNSSTYHHLHTFVNRETDTKRPDARLAAEEEAKRLEELQK 227
P + E + V+ ++VKT + + +E KR + + +E L +K
Sbjct: 261 EENPESDGEPV-VEDGTSVKTLETLQQRVK---RQENLLKRCKETIQSHKEQCTLLTSEK 316
Query: 228 QAAQERMERFEKAHVRGFQAMKKIHLA--------------------QNQEKLMKELKQL 267
+A QE+++ ++ + +K +H+A Q++ ++ E K+
Sbjct: 317 EALQEQLDE----RLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQ 372
Query: 268 QQEDLARRRQTVAQMPPQLVELPYKRSEMKEDWQRELEFAFEDM----------YNADRK 317
E L + + +AQ+ ++ ++ + E++E ++ AFE++ A RK
Sbjct: 373 MHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRK 432
Query: 318 VKGNLILHLEPEPLPTVTNQIQDEELDLSME----------------QENLGAAEDLPVT 361
+K + E + T+ ++E + L E +E + + L
Sbjct: 433 LKAEM-----DEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKL--H 485
Query: 362 EAEICSSETDVPLVMKTQQIPSKVLFKKLLNKIRSQKSLWTIKSMSEDESEMITTVSEIE 421
E E+ E ++ ++T++ + K L K SQ I E + + E++
Sbjct: 486 EKELARKEQELTKKLQTREREFQEQMKVALEK--SQSEYLKISQEKEQQESLALEELELQ 543
Query: 422 SKAPTVESGTIASKERTLSSGQEQVVESDTLTIESGPLASEDKPLSCGTNSGK------E 475
KA ES +K R L + + + L +ES S +K L N K E
Sbjct: 544 KKAILTES---ENKLRDLQQ-EAETYRTRILELES----SLEKSLQENKNQSKDLAVHLE 595
Query: 476 QEINETLPITTV------AQSSVLLHPQEAAARIRMSARQKQIMEIEEQKQKQLE-LLEQ 528
E N+ TV + L H Q+A +++ +++Q Q ++E L E+
Sbjct: 596 AEKNKHNKEITVMVEKHKTELESLKHQQDA-------LWTEKLQVLKQQYQTEMEKLREK 648
Query: 529 IEQQKLRLETD---CFRAQLEEEKRKKTQPTGVGIAPASCPVISDEDSHRQMIRNYQHQL 585
EQ+K L D F+A +EE K + + + +S E S + +H+L
Sbjct: 649 CEQEKETLLKDKEIIFQAHIEEMNEKTLEK--LDVKQTELESLSSELSE---VLKARHKL 703
Query: 586 LQQNRLHRQSVETARKQLLEYQTMLKGRCPSVSAPSLITDSVISVPSWKSERPTAISEHW 645
++ + + + KQ LE + + S+I + +S+ ++E+ A+ +
Sbjct: 704 EEELSVLKDQTD-KMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQ--RTEK--ALKDQI 758
Query: 646 DQGQRLKLSPNKYQPIQPIQTSKLEQDHFQVARQNHFPQRQVETTETLRASDILTNQALE 705
+Q + L +K+ LE D + + E + D+ +
Sbjct: 759 NQLELLLKERDKHLKEHQAHVENLEAD---------IKRSEGELQQASAKLDVFQSYQSA 809
Query: 706 SQEHLRQFSQTETQQRDYKLVPKDSETLSRALSHDRQLISQDARKISETFGATTFQSLE- 764
+ E + + + + Q KL+ D ET L+ + + + A Q +
Sbjct: 810 THEQTKAYEE-QLAQLQQKLL--DLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDL 866
Query: 765 SQQLFSENSENISYHLTEPSSFVPLVPQHSFSSLPVKVESGKIQEPFSAMSKSTVSTSHS 824
QQL +NSE + + + V + K+E G ++ +K + +
Sbjct: 867 MQQLEKQNSE-----MEQKVKSLTQVYES-------KLEDGNKEQ---EQTKQILVEKEN 911
Query: 825 IISQMHDRPL----LPSENITAQQGNMKALQEQLDL-----QKKVLQATQEAQEQLLLCK 875
+I QM + + ++ ++A++ ++ L E+ + +KK+ + Q+A+E K
Sbjct: 912 MILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLK 971
Query: 876 QKEVEQQTGLSVFLPLVTPDSSALLPSAKADLGRIQESSPTKNNIAVSSDHHVISQLQDK 935
+K ++Q+ L L +++AL S K + + N A SD +S+L+
Sbjct: 972 KKLLDQEAKLKKEL-----ENTALELSQKEKQFNAKMLEMAQANSAGISD--AVSRLETN 1024
Query: 936 RL----SLSQPILSQQNN-FKFLQEQLNIQKDSLQARREAQEVLYVHKQSELDRRVCSEQ 990
+ SL++ + N+ +++LN Q + LQ E Q + +EL +++
Sbjct: 1025 QKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFG 1084
Query: 991 AEPSFPFQVAQHTFTSLPSADTKSGKIQEQHSSKS---------EKGLVSCQSDIPISQD 1041
E + DT ++QEQ KS E L + + + +
Sbjct: 1085 CEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLN 1144
Query: 1042 GSL---SFLQQFLPLHDSLKLLQEQLTKQRDTLQARHEAQVELLLHRQRDLGDSKSGLVS 1098
SL +FLQ+ L LK+L E+ ++ L ++ + E + S L
Sbjct: 1145 KSLKENTFLQEQLV---ELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLED 1201
Query: 1099 SS------SSPVVVQHSVASQASAKAEPRRIQEL--YLSEKENVGPS----CH------- 1139
S S + +Q + + + + EL S K N S C
Sbjct: 1202 KSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVK 1261
Query: 1140 --LIIPTFQDKSLSFPQHSLAQQENLTILQEQSQIQRVILGAKEGTQEFVHTESELEKRI 1197
L+I T L L +++N + Q ++ +E + ++++E +
Sbjct: 1262 EALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQL----EEKENQIKSMKADIESLV 1317
Query: 1198 SSEQTGTSSSLSQVDESERFQECIS-IKSDSTIPLSHPKIPR--CQERLLRVSQHMLPLQ 1254
+ ++ +Q + + CI+ +K + + ++ + + +E+ + +S L
Sbjct: 1318 TEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLT 1377
Query: 1255 D-NLEEHQAWLDTEKEAFHFSQKTQENTSSEQTGSSSFIPQLVQLSF-TSLASAESGTIL 1312
D N++ + +EKEA S + Q + + Q+ LSF S E + L
Sbjct: 1378 DLNVQLQNSISLSEKEAAISSLRKQYDEE-----KCELLDQVQDLSFKVDTLSKEKISAL 1432
Query: 1313 EPL------FTESESKIFSSHLQ----IPQLQDRLLRISQLIQPQQDNLKALQEQLATQR 1362
E + F+E + K S Q + +LQ +L S+ + + + L+E+L Q
Sbjct: 1433 EQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQN 1492
Query: 1363 EAIILARQEAREELLLHQSEWEGRISPEQVDTSSLPLVPQHSFASLPLNESERNQEPCSI 1422
+ + E ++ +S+ E + S + + S A + E Q+ I
Sbjct: 1493 KRFDCLKGEMEDD----KSKMEKKESNLETELKS-------QTARIMELEDHITQKTIEI 1541
Query: 1423 NSDNIVSSGHSEIPTLPDGLL--GLSHL----------VLPQQDNLIALEEHLHAQTDFL 1470
S N V +++ + L L H V ++ ++ LE +++ L
Sbjct: 1542 ESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAEL 1601
Query: 1471 PSIEKTQKELVLSKPCKFEEKVSSEHFIQSHHGDLQALQQQLDTQKKAIRSIQEVQEELL 1530
+ +K + + LS K EE + E ++S ++ + + ++KA + I ++++L
Sbjct: 1602 ETKKKELEHVNLSVKSKEEELKALEDRLES-----ESAAKLAELKRKAEQKIAAIKKQL- 1655
Query: 1531 LQRLSELEKRVSSEQVCSSSFVSQVPVADSERTQKSFPTKSNDTLPSSHREIPRLQDRLL 1590
LS++E++ + + S +S++ N L RE+ L+++L
Sbjct: 1656 ---LSQMEEKEEQYKKGTESHLSEL----------------NTKLQEREREVHILEEKLK 1696
Query: 1591 SLSKP-----ILPQQDNMTA------QLDAQREVMYSYEKPQEELSLN---KQRKLNK-S 1635
S+ I+P+ A + D+Q V +YE+ L N K++ L +
Sbjct: 1697 SVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVG 1756
Query: 1636 ESAEHTIPSLF-LPKETEHSFIPLPFAEAK 1664
+ E T+ S F + + + I L AEAK
Sbjct: 1757 QEKEETVSSHFEMRCQYQERLIKLEHAEAK 1786
Score = 72.4 bits (176), Expect = 5e-12
Identities = 231/1266 (18%), Positives = 502/1266 (39%), Gaps = 150/1266 (11%)
Query: 704 LESQEHLRQFSQTETQQRDYKLVPKDSETLSRALSHDRQLISQ--DARKISETFGATTFQ 761
+E E + ET+++ ++ + E +++ S +Q+ +Q + R+ E F+
Sbjct: 355 IEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFE 414
Query: 762 SLE----SQQLFSENSENISYHLTEPSSFVPLVPQHSFSSLPVKVESGKIQEPFSAMSKS 817
LE + Q E + + E + + SL ++ K QE M KS
Sbjct: 415 ELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVK-QEVVDVMKKS 473
Query: 818 TVSTSHSIISQMHDRPLLPSENITAQQGNMKALQEQLDLQKKVLQATQEAQEQLLLCKQK 877
+ + + ++H++ L E Q+ K + + Q+++ A +++Q + L Q+
Sbjct: 474 S-EEQIAKLQKLHEKELARKE----QELTKKLQTREREFQEQMKVALEKSQSEYLKISQE 528
Query: 878 EVEQQTGLSVFLPLVTPDSSALLPSAKADLGRIQESSPTKNNIAVSSDHHVISQLQDKR- 936
+ +Q+ S+ L + A+L ++ L +Q+ + T + + + LQ+ +
Sbjct: 529 KEQQE---SLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKN 585
Query: 937 --LSLSQPILSQQNNF-KFLQEQLNIQKDSLQARREAQEVLYVHK--------QSELD-- 983
L+ + +++N K + + K L++ + Q+ L+ K Q+E++
Sbjct: 586 QSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKL 645
Query: 984 RRVCSEQAEPS-------FPFQVAQHTFTSLPSADTKSGKIQEQHSSKSE--KGLVSCQS 1034
R C ++ E F + + +L D K +++ S SE K +
Sbjct: 646 REKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEE 705
Query: 1035 DIPISQDGSLSFLQQF-----------------------LPLHDSLKLLQEQ------LT 1065
++ + +D + Q+ + + + K L++Q L
Sbjct: 706 ELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLL 765
Query: 1066 KQRDTLQARHEAQVELLLHRQRDLGDSKSGLVSSSSSPVVVQ-HSVASQASAKAEPRRI- 1123
K+RD H+A VE L + D+ S+ L +S+ V Q + A+ KA ++
Sbjct: 766 KERDKHLKEHQAHVENL---EADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLA 822
Query: 1124 ---QELYLSEKENVGPSCHLIIPTFQDKSL--SFPQHSLAQQENLTILQEQS----QIQR 1174
Q+L E E + + + Q K + H + Q+ + L++Q+ Q +
Sbjct: 823 QLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVK 882
Query: 1175 VILGAKEGTQEFVHTESELEKRISSEQTGTSSSL--SQVDESERFQECISIKSDSTIPLS 1232
+ E E + E E K+I E+ + Q E E + +S K DS L+
Sbjct: 883 SLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILN 942
Query: 1233 HP---KIPRCQERLLRVSQHMLPLQDNLEEHQAWLDTEKEAFHFSQKTQENTSSEQTGSS 1289
K ++++ +V Q +Q+ L++ LD E + + T S ++ +
Sbjct: 943 EEYETKFKNQEKKMEKVKQKAKEMQETLKKKL--LDQEAKLKKELENTALELSQKEKQFN 1000
Query: 1290 SFIPQLVQLSFTSLASAESGTILEPLFTESESKIFS-SHLQIPQLQDRLLRISQLIQPQQ 1348
+ + ++ Q + ++ A S L T + +I S + + +L D + + + Q
Sbjct: 1001 AKMLEMAQANSAGISDAVSR-----LETNQKEQIESLTEVHRRELNDVISIWEKKLNQQA 1055
Query: 1349 DNLKALQEQLATQREAIILARQEAREELLLHQSEWEGR------ISPEQV--DTSSLPLV 1400
+ L+ + E ++E + E ++++LL E E + E V DT+ L
Sbjct: 1056 EELQEIHEIQLQEKEQEVA---ELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQ 1112
Query: 1401 PQHSFASLPLNESERNQEPCSINSDNI---VSSGHSEIPTLPDGLLGLSHLVLPQQDNLI 1457
Q S +N +++ + + + ++ E L + L+ L L + +
Sbjct: 1113 EQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVS 1172
Query: 1458 ALEEHLHAQTDFLPSI----EKTQKELVLSKPCKFEEKVSSEHFIQSHHGDL--QALQQQ 1511
L L + S+ EK+ K L K +F+ K+S E IQ D+ + +
Sbjct: 1173 ELTSKLKTTDEEFQSLKSSHEKSNKSLE-DKSLEFK-KLSEELAIQL---DICCKKTEAL 1227
Query: 1512 LDTQKKAIRSIQEVQEELLLQRLSELEKRVSSEQVCSSSFVSQVPVADSERTQKSFPTKS 1571
L+ + + +I + +L R+S + R + +V + + V++ E + +
Sbjct: 1228 LEAKTNELINISSSKTNAILSRISHCQHRTT--KVKEALLIKTCTVSELEAQLRQLTEEQ 1285
Query: 1572 NDTLPSSHREIPRLQDR------------LLSLSKPILPQQDNMTAQLDAQREVMYSYEK 1619
N S + +L+++ L K L ++ Q +++E + K
Sbjct: 1286 NTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLK 1345
Query: 1620 PQEELSLNKQRKLNKSESAEHTIPSLFLPKETEHSFIPLPFAEAKPKSTCELYSSQNEHA 1679
+ ++N L K E E + L K+ + L + + + + S + ++
Sbjct: 1346 KELSENINAVT-LMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYD 1404
Query: 1680 APPSNPVIPGFQDRLLSFSQSVLTQQDNLGLQKQLDLQREVLHYSQKAQEKLLVQRQTAL 1739
++ QD LSF L+++ L++ D + + +KAQ + + T
Sbjct: 1405 EEKCE-LLDQVQD--LSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVK 1461
Query: 1740 QQQIQKHEETLKDFFKDSQISKPTVENDLKTQKMGQLRDWFPNTQDLAGNDQENIRHADR 1799
+ QIQ ++ + + KD QI+ E D + ++ L+ + + + N+ +
Sbjct: 1462 ELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELK 1521
Query: 1800 NNSD-----DNHLASEDTSAKQSGEHL-----EKDLGRRSSKPPVAKVKCGLDLNQHELS 1849
+ + ++H+ + + E L +KD+ K V K++ +L + + +
Sbjct: 1522 SQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDI---EHKELVQKLQHFQELGEEKDN 1578
Query: 1850 AIQEVE 1855
++E E
Sbjct: 1579 RVKEAE 1584
Score = 70.9 bits (172), Expect = 2e-11
Identities = 275/1451 (18%), Positives = 549/1451 (37%), Gaps = 279/1451 (19%)
Query: 8 THKLRLSPNEEAFILKE---DYERRRKLRLLQVRE---QERDIALQIREDIKQRRNQQFT 61
TH+ + E+ L++ D E R L QV E Q++D+ ++ D + + Q
Sbjct: 810 THEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTEL--DAHKIQVQDLM 867
Query: 62 RLAEELRAEWEESQTQKIQNLEKLYLASLRSMGEGHRQAKE---------------NEPD 106
+ E+ +E E QK+++L ++Y + L + Q K+ + +
Sbjct: 868 QQLEKQNSEME----QKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKE 923
Query: 107 LDALAQRAAERKRKADLRHKEALKVQKNQKEIL--LKQKTWHIKARKEALLVEKERSAK- 163
++ L Q+ + ++ + ++E KNQ++ + +KQK ++ + L+++E K
Sbjct: 924 IEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKK 983
Query: 164 -ITSLPPPPPTLFENIEVKRISAVKTNSSTYHHLHTFVNR-ETDTKRPDARLAAEEEAKR 221
+ + + K + + NS+ + V+R ET+ K E+ +
Sbjct: 984 ELENTALELSQKEKQFNAKMLEMAQANSAG---ISDAVSRLETNQK---------EQIES 1031
Query: 222 LEELQKQAAQERMERFEKAHVRGFQAMKKIHLAQNQEKLMKELKQLQQEDLARRRQTVAQ 281
L E+ ++ + + +EK + + +++IH Q QEK Q VA+
Sbjct: 1032 LTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEK----------------EQEVAE 1075
Query: 282 MPPQLVELPYKRSEMKEDWQRELEFAFEDMYNADRKVKGNLILHLEPEPLPTVTNQIQDE 341
+ +++ ++ EM +E+ + E+ D T N++Q++
Sbjct: 1076 LKQKILLFGCEKEEM----NKEITWLKEEGVKQD-----------------TTLNELQEQ 1114
Query: 342 ELDLSMEQENLGAAEDLPVTEAEICSSETDVPLVMKTQQIPSKVLFKKLLNKIRSQKSLW 401
S +L A+D +A + E D L K L Q+ L
Sbjct: 1115 LKQKSAHVNSL--AQDETKLKAHLEKLEVD--------------LNKSLKENTFLQEQLV 1158
Query: 402 TIKSMSEDESEMITTVSEIESKAPTVE---SGTIASKERTLSSGQEQVVESDTLTIESGP 458
+K ++E++ VSE+ SK T + +S E++ S +++ +E L+ E
Sbjct: 1159 ELKMLAEEDKR---KVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEE--- 1212
Query: 459 LASEDKPLSCGTNSGKEQEINETLPITTVAQSSVL---LHPQEAAARIR---------MS 506
LA + T + E + NE + I++ +++L H Q +++ +S
Sbjct: 1213 LAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVS 1272
Query: 507 ARQKQIMEIEEQK-------QKQLELLEQIEQQKLRLETDCFRAQLEEEKRKKTQPTGVG 559
+ Q+ ++ E++ Q+ LE+ E Q ++ D E+E +K
Sbjct: 1273 ELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQ 1332
Query: 560 IAPASCPVISDEDSHRQMIRNYQHQLLQQNRLHRQSVE--TARKQLLEYQTMLKGRCPSV 617
A I+ +++ N L + L + VE + KQL + L+ S+
Sbjct: 1333 AASEKESCIT--QLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQN---SI 1387
Query: 618 SAPSLITDSVISVPSWKSERPTAISEHWDQGQRLK-----LSPNKYQPIQPIQTSKLEQD 672
S +++ ++ S + + E DQ Q L LS K ++ + +
Sbjct: 1388 S----LSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFS 1443
Query: 673 HFQVARQNHFPQRQVETTETLRASDILTNQALESQEHLRQFSQTETQQRDYKLVPKDSET 732
++ Q+ F Q Q E ++ + +A E E + + QQ K +
Sbjct: 1444 EWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQN------KRFDC 1497
Query: 733 LSRALSHDRQLISQDARKISETFGATTFQSLESQQLFSENSENISYHLTEPSSFVPLVPQ 792
L + D+ + + + + T + +E + H+T+ + +
Sbjct: 1498 LKGEMEDDKSKMEKKESNLETELKSQTARIMELED-----------HITQKT-----IEI 1541
Query: 793 HSFSSLPVKVESGKIQEPFSAMSKSTVSTSHSIISQMHDRPLLPSENITAQQGNMKALQE 852
S + + K E + K + + + +R E I + + +++
Sbjct: 1542 ESLNEVLKNYNQQKDIEHKELVQK--LQHFQELGEEKDNRVKEAEEKILTLENQVYSMKA 1599
Query: 853 QLDLQKKVLQATQEAQEQLLLCKQKEVEQQTGLSVFLPLVTPDSSALLPSAKADLGRIQE 912
+L+ +KK L+ L K KE E L + +S+A L A+L R E
Sbjct: 1600 ELETKKKELEHVN------LSVKSKEEE----LKALEDRLESESAAKL----AELKRKAE 1645
Query: 913 SSPTKNNIAVSSDHHVISQLQDKR-----------LSLSQPILSQQNNFKFLQEQL---- 957
+ ++SQ+++K L+ + ++ L+E+L
Sbjct: 1646 QK------IAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVE 1699
Query: 958 NIQKDSLQARREAQEVLYVHKQSELDRRVCSEQAEPSFPFQVAQHTFTSLPSADTKSGKI 1017
+ Q ++L R A+ V +Q E D + C ++ V Q T + G
Sbjct: 1700 SSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEE-KISVLQRNLTEKEKLLQRVG-- 1756
Query: 1018 QEQHSSKSEKGLVSCQSDIPISQDGSLSFLQQFLPLHDSLKLLQEQLTKQRDTLQARHEA 1077
QE+ + S + CQ QE+L K +HE
Sbjct: 1757 QEKEETVSSHFEMRCQ--------------------------YQERLIKLEHAEAKQHED 1790
Query: 1078 QVELLLHRQRDLGDSKSGLVSSSSSPVVVQHSVASQASAKAEPRRIQELYLSEKENVGPS 1137
Q ++ H Q +L + + S +V QH + IQ K+N+
Sbjct: 1791 Q-SMIGHLQEELEEK-----NKKYSLIVAQH-----VEKEGGKNNIQ-----AKQNLENV 1834
Query: 1138 CHLIIPTFQDKSLSFPQHSLAQQENLTILQEQSQIQRVILGAKEGTQEFVHTESELEKRI 1197
+ T Q+K L+ +E + L Q ++ RV + E + +++ R
Sbjct: 1835 FDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGR- 1893
Query: 1198 SSEQTGTSSSLSQVDESERFQECISIKSDSTIPLSHP----KIPRCQERLLRVSQHMLPL 1253
+ L + E + + K S + H K+ + ++ + ++ L
Sbjct: 1894 ----NKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRL 1949
Query: 1254 QDNL----EEHQAWLDTEKEAFHFSQKTQENTSSEQTG----SSSFIPQLVQLSFTSLAS 1305
Q +L +EHQ L+ K+ + Q+ +E EQ +S + QL++ T LA
Sbjct: 1950 QKDLRMLRKEHQQELEILKK--EYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQ 2007
Query: 1306 AESG---TILEPL--FTESESKIFSSHLQIPQLQDRLLRISQLIQPQQDNLKALQEQLAT 1360
E TI E + E E+++ SH Q+ ++ + I + D+LK + A
Sbjct: 2008 KEQELEMTIKETINKAQEVEAELLESH------QEETNQLLKKIAEKDDDLK----RTAK 2057
Query: 1361 QREAIILARQE 1371
+ E I+ AR+E
Sbjct: 2058 RYEEILDAREE 2068
Score = 53.9 bits (128), Expect = 2e-06
Identities = 118/563 (20%), Positives = 225/563 (39%), Gaps = 83/563 (14%)
Query: 12 RLSPNEEAFILKEDYERRRKLRLLQVREQERDIALQIR---EDIKQRRNQQFTRLAEELR 68
R+ EE + E+ K L +++ + L ++ E++K ++ + A +L
Sbjct: 1579 RVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKL- 1637
Query: 69 AEWEESQTQKIQNLEKLYLASLRSMGEGHRQAKENEPDLDALAQRAAERKRKADLRHKEA 128
AE + QKI ++K L+ + E +++ E+ L L + ER+R+ + ++
Sbjct: 1638 AELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESH--LSELNTKLQEREREVHILEEKL 1695
Query: 129 LKVQKNQKEILLKQKTWHIKARKEALLVEKERSAKITSLPPPPPTLFENIEV-------- 180
V+ +Q E L+ ++ A+ A E+E + S T E I V
Sbjct: 1696 KSVESSQSETLIVPRS----AKNVAAYTEQEEA---DSQGCVQKTYEEKISVLQRNLTEK 1748
Query: 181 ----KRISAVKTNSSTYHHLHTFVNRETDTKRPDARLAAEEEAKRLEELQKQAAQERMER 236
+R+ K + + H +E K A E+ + LQ++ +E+ ++
Sbjct: 1749 EKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEEL-EEKNKK 1807
Query: 237 FE---KAHVRGFQAMKKIHLAQNQEKLMKEL-KQLQQEDLARRRQTVAQMPPQLVELPYK 292
+ HV I QN E + ++ K LQ+++L Q + Q +L +
Sbjct: 1808 YSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTC--QILEQKIKELDSCLVR 1865
Query: 293 RSEMKEDWQRELEFAFEDMY-----------------NADRKVKGNLILHLEPEPLPTVT 335
+ E+ EL +E + N + K K +L+ +P+ L +
Sbjct: 1866 QKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLV---QPKLLSNME 1922
Query: 336 NQIQDEELDLSMEQENLGAAEDLPVTEAEICSSETDVPLVMKTQQIPSKVLFKKLLNKIR 395
Q D E L+ GA + EI + D+ ++ K Q ++L KK ++ R
Sbjct: 1923 AQHNDLEFKLA------GAEREKQKLGKEIVRLQKDLRMLRKEHQQELEIL-KKEYDQER 1975
Query: 396 SQKSLWTIKSMSED-ESEMITTVSEIESKAPTVESGTIASKERTLSSGQEQVVESDTLTI 454
+K IK ED E + +T+ ++ + T +A KE+ L ++ + +
Sbjct: 1976 EEK----IKQEQEDLELKHNSTLKQLMREFNT----QLAQKEQELEMTIKETINK-AQEV 2026
Query: 455 ESGPLASEDKPLSCGTNSGKEQEINETLPITTVAQSSVLLHPQEAAARIRMSARQKQIME 514
E+ L S ++E N+ L +A+ L + AR++++
Sbjct: 2027 EAELLESH------------QEETNQLLK--KIAEKDDDLKRTAKRYEEILDAREEEMTA 2072
Query: 515 IEEQKQKQLELLEQIEQQKLRLE 537
Q QLE L++ QQKL E
Sbjct: 2073 KVRDLQTQLEELQKKYQQKLEQE 2095
Score = 45.8 bits (107), Expect = 5e-04
Identities = 80/395 (20%), Positives = 157/395 (39%), Gaps = 44/395 (11%)
Query: 35 LQVREQERDIALQIREDIKQRRNQQFTRLAEELRAEWEESQTQKIQNLEKLYLASLRSMG 94
++ + QER I L+ E + L EEL + ++ Q++EK G
Sbjct: 1769 MRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEK-------EGG 1821
Query: 95 EGHRQAKEN-EPDLDALAQRAAERKRKADLRHKEALKVQKNQKEILLKQKTWHIKARKEA 153
+ + QAK+N E D + + E++ + ++ K L++QK H + E
Sbjct: 1822 KNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKI----KELDSCLVRQKEVH-RVEMEE 1876
Query: 154 LLVEKERSAKITSLP---PPPPTLFENIEVKRISAVKTNSSTYHHLHTFVNRETDTKRPD 210
L + E+ + + P L EN E K + S N E +
Sbjct: 1877 LTSKYEKLQALQQMDGRNKPTELLEENTEEK-------SKSHLVQPKLLSNMEAQHNDLE 1929
Query: 211 ARLAAEEEAKRLEELQKQAAQERMERFEKAHVRGFQAMKKIHLAQNQEKLMKELKQLQQE 270
+LA E K+ + Q+ + K H + + +KK + + +EK+ +E + L+ +
Sbjct: 1930 FKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELK 1989
Query: 271 DLARRRQTVAQMPPQLVELPYKRSEMKEDWQRELEFAFEDMYNADRKVKGNLILHLEPEP 330
+ +Q + + QL + ++ELE ++ N ++V+ L+ + E
Sbjct: 1990 HNSTLKQLMREFNTQLAQK-----------EQELEMTIKETINKAQEVEAELLESHQEE- 2037
Query: 331 LPTVTNQIQDE--ELDLSMEQENLGAAEDLPVTEAEICSSETDVPLVMKTQQIPSKVLFK 388
TNQ+ + E D +++ E L E E+ + D+ ++ Q K +
Sbjct: 2038 ----TNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQ---KKYQQ 2090
Query: 389 KLLNKIRSQKSLWTIKSMSEDESEMITTVSEIESK 423
KL + TI + ++ T +S+ + K
Sbjct: 2091 KLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLK 2125
Score = 39.3 bits (90), Expect = 0.051
Identities = 36/144 (25%), Positives = 71/144 (49%), Gaps = 6/144 (4%)
Query: 11 LRLSPNEEAFILKEDYERRRKLRLLQVREQERDIALQIREDIKQRRNQQFTRLAEELRAE 70
LR +E ILK++Y++ R+ + +++++ D+ L+ +KQ + T+LA++ E
Sbjct: 1956 LRKEHQQELEILKKEYDQEREEK---IKQEQEDLELKHNSTLKQLMREFNTQLAQK-EQE 2011
Query: 71 WEESQTQKIQNLEKLYLASLRSMGEGHRQAKENEPDLDALAQRAAERKRK-ADLRHKE-A 128
E + + I +++ L S E Q + + D +R A+R + D R +E
Sbjct: 2012 LEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMT 2071
Query: 129 LKVQKNQKEILLKQKTWHIKARKE 152
KV+ Q ++ QK + K +E
Sbjct: 2072 AKVRDLQTQLEELQKKYQQKLEQE 2095
Score = 35.8 bits (81), Expect = 0.57
Identities = 42/179 (23%), Positives = 78/179 (43%), Gaps = 28/179 (15%)
Query: 2436 SEFLPLVSATEASDYPAVSELSIEKPRTASTETPRRLTPVPGSLQEAFIKRKKSFMERSH 2495
SE+L + E + A+ EL ++K + TE+ +L + QEA R + +E
Sbjct: 520 SEYLKISQEKEQQESLALEELELQK-KAILTESENKLRDLQ---QEAETYRTR-ILELES 574
Query: 2496 QRQKEIRNKIHVSENSQIKTVKEKPSISSSVSRLKGVNKVRASFPEDRKTTQALRHQRGL 2555
+K ++ + S++ + EK + ++ + +K ++L+HQ+
Sbjct: 575 SLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTEL---------ESLKHQQDA 625
Query: 2556 RLYNQLAEVKQQKE-------EKTKQEAYAQNR-------ARAKEFHKKTLEKLRAKNT 2600
+L +KQQ + EK +QE + A +E ++KTLEKL K T
Sbjct: 626 LWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQT 684
>gi|148536869 ninein isoform 2 [Homo sapiens]
Length = 2133
Score = 80.5 bits (197), Expect = 2e-14
Identities = 294/1431 (20%), Positives = 543/1431 (37%), Gaps = 200/1431 (13%)
Query: 9 HKLRLSPNEEAFILKEDYERRRKLRLLQVREQERDIALQIREDIKQRRNQQFTRLAEELR 68
H+ +L+ E L+++ R+ L Q QE RE ++ N++ +++ + +
Sbjct: 766 HQEQLTSLVEKHTLEKEELRKELLEKHQRELQEG------REKMETECNRRTSQIEAQFQ 819
Query: 69 AEWE---ESQTQKIQNLEKLYLASLRSMGEGHRQAKEN-EPDLDALAQRAAERKRKADLR 124
++ + E +Q+LE Y L+ + E R+ K E + D L Q AE
Sbjct: 820 SDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAE-------- 871
Query: 125 HKEALKVQKNQKEILLKQKTWHIKARKEALLVEKERSAKITSLPPPPPTLFENIE-VKRI 183
Q+ KE L ++KT + +E ++EK + S+ L +++E ++ +
Sbjct: 872 ------AQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNV 925
Query: 184 SAVKTNSSTYHHL-----HTFVNRETDTKRPDARLAAEEEAKRLEELQKQAAQERMERFE 238
S + + + L H RE + A + + ++RLE L+ + QER E
Sbjct: 926 SETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMS 985
Query: 239 KAHVRGFQAMKKIHLAQNQEKLMKELKQLQQEDLARRRQTVAQMPPQLVELPYKRSEMKE 298
K AM+ IH A E +E ++ E ++R + + +M L +S +
Sbjct: 986 K-----LLAMENIHKA-TCETADRERAEMSTE-ISRLQSKIKEMQQATSPLSMLQSGCQV 1038
Query: 299 DWQRELEF--AFEDMYNADRKVK--GNLILHLEPEPLPTVTNQIQDEELDLSMEQENLGA 354
+ E+E A + ++ ++ G+++L L+ V ++ ++S Q+ L
Sbjct: 1039 IGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVK-MATEISRLQQRLQK 1097
Query: 355 AEDLPVTEAEICSSETDVPLVMKTQQIPSKVLFKKLLNKIRSQKSLWTIKSMSEDESEMI 414
E P C E T + L + ++ + + +DE +
Sbjct: 1098 LE--PGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDL 1155
Query: 415 --TTVSEIESKAPTVESGTIASKE--RTLSSGQEQVVESDTLTIESGPLASEDKPLSCGT 470
T S ++ + +E AS E L + +E ES L + L + L
Sbjct: 1156 GSTGTSSVQRQEVKIEESE-ASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADC 1214
Query: 471 NSGKEQEINETLPITTVAQSSVLLHP-QEAAARIRMS----ARQKQIMEIEEQKQKQLEL 525
+ E++ + ++ + + +L EA+ + ++ +R+ ++ EE + +
Sbjct: 1215 DRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQ-EELRMMETRY 1273
Query: 526 LEQIEQQKLRLETDCFRAQLEEEKRKKTQPTGVGIAPASCPVISDEDSHRQMIRNYQHQL 585
E +E K L + FR Q E +K ++ T + + + V + + ++ Q ++
Sbjct: 1274 DEALENNK-ELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKI 1332
Query: 586 LQQNRLHRQSVETARKQLLEYQTMLKGRCPSVSAPSLITDSVISVPSWKSERPTAISEHW 645
+L V+ L E P + L VP +S I E
Sbjct: 1333 ---EKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHV-IEECK 1388
Query: 646 DQGQRLKLSPNKYQPIQPIQTSKLE---QDHFQVAR-QNH-----------FPQRQVETT 690
+ Q L+ + + ++ + + L Q H + R QN F + +
Sbjct: 1389 QENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQ 1448
Query: 691 ETLRASDILTNQALESQEHLRQFSQTETQQRDYKLVPKDSETLSRALSHDRQLISQDARK 750
T+ ++ + E L++ +Q+D + E L +A+ HD Q+ + ++
Sbjct: 1449 ATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEEL-KAMMHDLQITCSEMQQ 1507
Query: 751 ISETFGATTFQSLESQQLFSENSENISYHLTEPSSFVPLVPQHSFSSLPVKVESGKIQEP 810
E ES++L ENS + L + S S+L + +G +E
Sbjct: 1508 KVELL------RYESEKLQQENS-------ILRNEITTLNEEDSISNLKLGTLNGSQEEM 1554
Query: 811 FSAMSKSTVSTSHSIISQMHDRPLLPSENITAQQGNMKALQEQLDLQKKVL-QATQEAQE 869
+ TV ++ + +M EN+ Q +K +QLDL+ L Q + QE
Sbjct: 1555 WQ--KTETVKQENAAVQKM-------VENLKKQISELKIKNQQLDLENTELSQKNSQNQE 1605
Query: 870 QL---------LLC-KQKE---------VEQQTGLSVFLPLVTPDSSALLPSAKADLGRI 910
+L +LC K+KE +++ L L SS L+ S +A+L +
Sbjct: 1606 KLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEV 1665
Query: 911 --------QESSPTKNNIAVSSDHHVISQLQDKRLSLSQPILSQQNNFK---FLQEQLNI 959
QE+ K+ + H L D + +S + + K L E+LN
Sbjct: 1666 KIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNS 1725
Query: 960 QKDSLQARREAQEVLYVHKQSELDRRVCSEQAEPSFPFQVAQHTFTSLPSADTKS-GKIQ 1018
D L K S L+ R+ + + E + +H SL S S K+Q
Sbjct: 1726 CVDKLA------------KSSLLEHRIATMKQEQ----KSWEHQSASLKSQLVASQEKVQ 1769
Query: 1019 EQHSSKSEKGL--VSCQSDIPISQDGSLSFLQQFLPLHDSLKLLQEQLTKQRDTLQARHE 1076
+ L +SD+ ++Q + Q+ + LH K LQ K A H
Sbjct: 1770 NLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLH---KQLQNAGGKSWAPEIATHP 1826
Query: 1077 AQVELLLHRQRDLGDSKSGLVSSSSSPVVVQHSVASQA---SAKAEPRRIQELYLSEKEN 1133
+ L ++Q+ L K + + ++ Q + Q + KAE +E + N
Sbjct: 1827 SG---LHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESN 1883
Query: 1134 VGPSCHLIIPTFQDKSLSFPQHSLAQQENLTILQEQSQIQRVILGAKEGTQEFVHTESEL 1193
++P Q + +QE L++ +E Q Q+ A + E EL
Sbjct: 1884 -------LLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQEL 1936
Query: 1194 EKRISSEQTGTSSSLSQVDESERFQECISIKSDSTIPLSHPKIPRCQERLLRVSQHMLPL 1253
E I E G QV E+ E ++S +T P P Q L + + M+P
Sbjct: 1937 E-TIHLENEGLKK--KQVKLDEQLMEMQHLRSTAT-PSPSPHAWDLQ-LLQQQACPMVPR 1991
Query: 1254 QDNLEEHQAWLDTEKEAFHFSQKTQENTSSEQTGSSSFIPQLVQLSFTSLASAESGTILE 1313
+ L+ + L E+ H Q+ EN +SE QLV T++E
Sbjct: 1992 EQFLQLQRQLLQAERINQHL-QEELENRTSETNTPQGNQEQLV-------------TVME 2037
Query: 1314 PLFTESESKIFSSHLQIPQLQDRLLRISQLIQPQQDNLKALQEQLATQREA 1364
E E K+ +L RLL Q+ + L+EQL +A
Sbjct: 2038 ERMIEVEQKL--------KLVKRLL---------QEKVNQLKEQLCKNTKA 2071
Score = 34.3 bits (77), Expect = 1.6
Identities = 56/220 (25%), Positives = 93/220 (42%), Gaps = 23/220 (10%)
Query: 1355 QEQLATQREAIILARQEAREELL-LHQSE-WEGRISPEQVDTSSLPLVPQHSFASLPLNE 1412
QEQL + E L ++E R+ELL HQ E EGR E+++T Q + ++
Sbjct: 767 QEQLTSLVEKHTLEKEELRKELLEKHQRELQEGR---EKMETECNRRTSQ--IEAQFQSD 821
Query: 1413 SERNQEPCSINSDNIVSSGHSEIPTLPDGLLGLSHLVLPQQDNLIALEEHLHAQTDFLPS 1472
++ E C ++ E+ L + ++D L +E AQ + L
Sbjct: 822 CQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDEL--TQECAEAQ-ELLKE 878
Query: 1473 IEKTQK--ELVLSKPCKFEEKVSSEHFIQSHHGDLQALQQQLDTQKKAIRSIQEVQEELL 1530
K +K LVL++ + EK EH + +QQL + +R++ E Q+ LL
Sbjct: 879 TLKREKTTSLVLTQEREMLEKTYKEHL-----NSMVVERQQLLQDLEDLRNVSETQQSLL 933
Query: 1531 LQRLSEL------EKRVSSEQVCSSSFVSQVPVADSERTQ 1564
++ EL E R E +C + Q+ ER +
Sbjct: 934 SDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLE 973
>gi|148536871 ninein isoform 1 [Homo sapiens]
Length = 2046
Score = 80.1 bits (196), Expect = 3e-14
Identities = 277/1361 (20%), Positives = 521/1361 (38%), Gaps = 170/1361 (12%)
Query: 9 HKLRLSPNEEAFILKEDYERRRKLRLLQVREQERDIALQIREDIKQRRNQQFTRLAEELR 68
H+ +L+ E L+++ R+ L Q QE RE ++ N++ +++ + +
Sbjct: 766 HQEQLTSLVEKHTLEKEELRKELLEKHQRELQEG------REKMETECNRRTSQIEAQFQ 819
Query: 69 AEWE---ESQTQKIQNLEKLYLASLRSMGEGHRQAKEN-EPDLDALAQRAAERKRKADLR 124
++ + E +Q+LE Y L+ + E R+ K E + D L Q AE
Sbjct: 820 SDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAE-------- 871
Query: 125 HKEALKVQKNQKEILLKQKTWHIKARKEALLVEKERSAKITSLPPPPPTLFENIE-VKRI 183
Q+ KE L ++KT + +E ++EK + S+ L +++E ++ +
Sbjct: 872 ------AQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNV 925
Query: 184 SAVKTNSSTYHHL-----HTFVNRETDTKRPDARLAAEEEAKRLEELQKQAAQERMERFE 238
S + + + L H RE + A + + ++RLE L+ + QER E
Sbjct: 926 SETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMS 985
Query: 239 KAHVRGFQAMKKIHLAQNQEKLMKELKQLQQEDLARRRQTVAQMPPQLVELPYKRSEMKE 298
K AM+ IH A E +E ++ E ++R + + +M L +S +
Sbjct: 986 K-----LLAMENIHKA-TCETADRERAEMSTE-ISRLQSKIKEMQQATSPLSMLQSGCQV 1038
Query: 299 DWQRELEF--AFEDMYNADRKVK--GNLILHLEPEPLPTVTNQIQDEELDLSMEQENLGA 354
+ E+E A + ++ ++ G+++L L+ V ++ ++S Q+ L
Sbjct: 1039 IGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVK-MATEISRLQQRLQK 1097
Query: 355 AEDLPVTEAEICSSETDVPLVMKTQQIPSKVLFKKLLNKIRSQKSLWTIKSMSEDESEMI 414
E P C E T + L + ++ + + +DE +
Sbjct: 1098 LE--PGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDL 1155
Query: 415 --TTVSEIESKAPTVESGTIASKE--RTLSSGQEQVVESDTLTIESGPLASEDKPLSCGT 470
T S ++ + +E AS E L + +E ES L + L + L
Sbjct: 1156 GSTGTSSVQRQEVKIEESE-ASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADC 1214
Query: 471 NSGKEQEINETLPITTVAQSSVLLHP-QEAAARIRMS----ARQKQIMEIEEQKQKQLEL 525
+ E++ + ++ + + +L EA+ + ++ +R+ ++ EE + +
Sbjct: 1215 DRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQ-EELRMMETRY 1273
Query: 526 LEQIEQQKLRLETDCFRAQLEEEKRKKTQPTGVGIAPASCPVISDEDSHRQMIRNYQHQL 585
E +E K L + FR Q E +K ++ T + + + V + + ++ Q ++
Sbjct: 1274 DEALENNK-ELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKI 1332
Query: 586 LQQNRLHRQSVETARKQLLEYQTMLKGRCPSVSAPSLITDSVISVPSWKSERPTAISEHW 645
+L V+ L E P + L VP +S I E
Sbjct: 1333 ---EKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHV-IEECK 1388
Query: 646 DQGQRLKLSPNKYQPIQPIQTSKLE---QDHFQVAR-QNH-----------FPQRQVETT 690
+ Q L+ + + ++ + + L Q H + R QN F + +
Sbjct: 1389 QENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQ 1448
Query: 691 ETLRASDILTNQALESQEHLRQFSQTETQQRDYKLVPKDSETLSRALSHDRQLISQDARK 750
T+ ++ + E L++ +Q+D + E L +A+ HD Q+ + ++
Sbjct: 1449 ATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEEL-KAMMHDLQITCSEMQQ 1507
Query: 751 ISETFGATTFQSLESQQLFSENSENISYHLTEPSSFVPLVPQHSFSSLPVKVESGKIQEP 810
E ES++L ENS + L + S S+L + +G +E
Sbjct: 1508 KVELL------RYESEKLQQENS-------ILRNEITTLNEEDSISNLKLGTLNGSQEEM 1554
Query: 811 FSAMSKSTVSTSHSIISQMHDRPLLPSENITAQQGNMKALQEQLDLQKKVL-QATQEAQE 869
+ TV ++ + +M EN+ Q +K +QLDL+ L Q + QE
Sbjct: 1555 WQ--KTETVKQENAAVQKM-------VENLKKQISELKIKNQQLDLENTELSQKNSQNQE 1605
Query: 870 QL---------LLC-KQKE---------VEQQTGLSVFLPLVTPDSSALLPSAKADLGRI 910
+L +LC K+KE +++ L L SS L+ S +A+L +
Sbjct: 1606 KLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEV 1665
Query: 911 --------QESSPTKNNIAVSSDHHVISQLQDKRLSLSQPILSQQNNFK---FLQEQLNI 959
QE+ K+ + H L D + +S + + K L E+LN
Sbjct: 1666 KIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNS 1725
Query: 960 QKDSLQARREAQEVLYVHKQSELDRRVCSEQAEPSFPFQVAQHTFTSLPSADTKS-GKIQ 1018
D L K S L+ R+ + + E + +H SL S S K+Q
Sbjct: 1726 CVDKLA------------KSSLLEHRIATMKQEQ----KSWEHQSASLKSQLVASQEKVQ 1769
Query: 1019 EQHSSKSEKGL--VSCQSDIPISQDGSLSFLQQFLPLHDSLKLLQEQLTKQRDTLQARHE 1076
+ L +SD+ ++Q + Q+ + LH K LQ K A H
Sbjct: 1770 NLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLH---KQLQNAGGKSWAPEIATHP 1826
Query: 1077 AQVELLLHRQRDLGDSKSGLVSSSSSPVVVQHSVASQA---SAKAEPRRIQELYLSEKEN 1133
+ L ++Q+ L K + + ++ Q + Q + KAE +E + N
Sbjct: 1827 SG---LHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESN 1883
Query: 1134 VGPSCHLIIPTFQDKSLSFPQHSLAQQENLTILQEQSQIQRVILGAKEGTQEFVHTESEL 1193
++P Q + +QE L++ +E Q Q+ A + E EL
Sbjct: 1884 -------LLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQEL 1936
Query: 1194 EKRISSEQTGTSSSLSQVDESERFQECISIKSDSTIPLSHPKIPRCQERLLRVSQHMLPL 1253
E I E G QV E+ E ++S +T P P Q L + + M+P
Sbjct: 1937 E-TIHLENEGLKK--KQVKLDEQLMEMQHLRSTAT-PSPSPHAWDLQ-LLQQQACPMVPR 1991
Query: 1254 QDNLEEHQAWLDTEKEAFHFSQKTQENTSSEQTGSSSFIPQ 1294
+ L+ + L E+ H Q+ EN +SE + +P+
Sbjct: 1992 EQFLQLQRQLLQAERINQHL-QEELENRTSETNTPQALLPE 2031
Score = 34.3 bits (77), Expect = 1.6
Identities = 56/220 (25%), Positives = 93/220 (42%), Gaps = 23/220 (10%)
Query: 1355 QEQLATQREAIILARQEAREELL-LHQSE-WEGRISPEQVDTSSLPLVPQHSFASLPLNE 1412
QEQL + E L ++E R+ELL HQ E EGR E+++T Q + ++
Sbjct: 767 QEQLTSLVEKHTLEKEELRKELLEKHQRELQEGR---EKMETECNRRTSQ--IEAQFQSD 821
Query: 1413 SERNQEPCSINSDNIVSSGHSEIPTLPDGLLGLSHLVLPQQDNLIALEEHLHAQTDFLPS 1472
++ E C ++ E+ L + ++D L +E AQ + L
Sbjct: 822 CQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDEL--TQECAEAQ-ELLKE 878
Query: 1473 IEKTQK--ELVLSKPCKFEEKVSSEHFIQSHHGDLQALQQQLDTQKKAIRSIQEVQEELL 1530
K +K LVL++ + EK EH + +QQL + +R++ E Q+ LL
Sbjct: 879 TLKREKTTSLVLTQEREMLEKTYKEHL-----NSMVVERQQLLQDLEDLRNVSETQQSLL 933
Query: 1531 LQRLSEL------EKRVSSEQVCSSSFVSQVPVADSERTQ 1564
++ EL E R E +C + Q+ ER +
Sbjct: 934 SDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLE 973
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 79.3 bits (194), Expect = 4e-14
Identities = 390/1989 (19%), Positives = 759/1989 (38%), Gaps = 349/1989 (17%)
Query: 1 MKRKVVNTHKLRLSPNEEAFILKEDYERRRKLRLLQVREQERDIALQIRE---------- 50
+K K+ KL L +E + K + KL L +++ER + +I++
Sbjct: 348 LKDKLTTADKL-LGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQK 406
Query: 51 ----------DIKQRRNQQFTRLAEELRAEWEESQTQKI----QNLEKLYLASLRSMGEG 96
DI QR Q+ R E+LRAE +E Q+I Q L + ++A + M
Sbjct: 407 RNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTR 466
Query: 97 HRQAKENEPDLDALAQRAAERKRKADLRHKEALKVQKNQKEILLKQKTWHIKARKEAL-L 155
H+ EN AL + + ++ + V N+ I L+ + KE L L
Sbjct: 467 HKGEMEN-----ALRSYSNITVNEDQIK---LMNVAINELNIKLQDTNSQKEKLKEELGL 518
Query: 156 VEKERSAKITSLPPPPPTLFENIEVKRISAVKTNSSTYHHLHTFVNRETDTKRPDARLAA 215
+ +E+ A L L E + R + T +E+ L+
Sbjct: 519 ILEEKCALQRQL----EDLVEELSFSREQIQRAR-------QTIAEQESKLNEAHKSLST 567
Query: 216 EEEAKRLEELQKQAAQERMERFEKAHVRGFQAMKKIHLAQNQEKLMKELKQLQQEDLARR 275
E+ K E + +++ +E +A V ++ +K L + + ++ + + Q+ +L R
Sbjct: 568 VEDLK-AEIVSASESRKELELKHEAEVTNYK-IKLEMLEKEKNAVLDRMAESQEAELERL 625
Query: 276 RQTVAQMPPQLVELPYKRSEMKEDWQRELEFAFEDMYNADRKVKGNLILHLEPEPLPTVT 335
R + L + S++KED + E E K+K NL +H + + + +
Sbjct: 626 RTQL------LFSHEEELSKLKEDLEIEHRINIE-------KLKDNLGIHYK-QQIDGLQ 671
Query: 336 NQIQDEELDLSMEQENLGAAEDLPVTEAEICSSETDVPLVMKTQQIPSKVLFKKLLNKIR 395
N++ + + E++NL ++ + E + K++++ ++ N++
Sbjct: 672 NEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQI------NEL- 724
Query: 396 SQKSLWTIKSMSEDESEMITTVSEIESKAPTVESGTIASKERTLSSGQEQVVESDTLTIE 455
QK + ++ +++ + V E++ K +E + KE L QE+ + L E
Sbjct: 725 -QKEIEILRQEEKEKGTLEQEVQELQLKTELLEK-QMKEKENDL---QEKFAQ---LEAE 776
Query: 456 SGPLASEDKPLSCGTNSGKEQEINETLPI-TTVAQSSVLLHPQEAAARIRMSARQKQ--- 511
+ L E K L + L I T V+Q L+ ++ + S +K+
Sbjct: 777 NSILKDEKKTL------------EDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEI 824
Query: 512 -IMEIEEQKQKQLELLEQIEQQKLRLETDCFRAQLEEEKRKKTQPTGVGIAPASCPVISD 570
I E E+ KQ+ ++L E+IE+Q+ T F + +
Sbjct: 825 LIEENEDLKQQCIQLNEEIEKQR---NTFSFAEK------------------------NF 857
Query: 571 EDSHRQMIRNYQHQLLQQNRLHRQSVETARKQLLEYQTMLKGRCPSVSAPSLITDSVISV 630
E +++++ Y L ++ L ++ KQ LEY++ LK + + +V
Sbjct: 858 EVNYQELQEEYACLLKVKDDLE----DSKNKQELEYKSKLKALNEELHLQRINPTTVKMK 913
Query: 631 PSWKSERPTAISEHWDQGQRL---------KLSPNKYQPIQPIQ-----TSKLEQDHFQV 676
S E T ++E + G+ + KL K + ++ Q + +L+Q H ++
Sbjct: 914 SSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEI 973
Query: 677 ARQNH----FPQRQVETTETLRASDILTNQALESQEHLRQFSQTETQQRDYKLVPKDSET 732
+ N Q + + + R +I+ N ++ Q T+ +V S
Sbjct: 974 SFLNEEVKSLKQEKEQVSLRCRELEIIIN---HNRAENVQSCDTQVSSLLDGVVTMTSRG 1030
Query: 733 LSRALSHDRQLISQDARKISET----FGATTFQSLESQQLFSENSENI----SYHLTEPS 784
++S + ++++ + E T + + +QL ++ ++ S T+PS
Sbjct: 1031 AEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPS 1090
Query: 785 SFVPLVPQHSFSSLPVKVESGKIQEPFSAMSKSTVSTSH-----SIISQMHDRPL--LPS 837
L Q + L + ++Q + S V ++H + D+ L L
Sbjct: 1091 ENDKL--QKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKE 1148
Query: 838 ENITAQQGNMKALQE--QLDLQKKVLQATQEAQEQLLLC---KQKEVEQQTGLSVFL-PL 891
E I AQ+ +K LQ+ QL+LQ Q T + + L L QK V ++ S FL L
Sbjct: 1149 ELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEE--CSYFLQTL 1206
Query: 892 VTPDSSALLPSAKADLGRIQESSPTKNNIAVSSDHHVISQLQDKRLSLSQPILSQQNNFK 951
+ P+ K ++ ++ K N + +LQD R + Q N
Sbjct: 1207 CSVLGEYYTPALKCEV-----NAEDKENSGDYISENEDPELQDYRYE----VQDFQENMH 1257
Query: 952 FLQEQLNIQKDSLQARREAQEVLYVHKQSELDRRVCSEQAEPSFPFQVAQHTFTSLPSAD 1011
L ++ + + L + ++ + + E E + P + + F S+ S
Sbjct: 1258 TLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMK----LEFGEENLPKEETE--FLSIHSQM 1311
Query: 1012 TKSGKIQEQHSSKSEKGLVSCQSDIPISQDGSLSFLQQFLPLHDSLKLLQEQLTKQRDTL 1071
T I H SK +S D+ +Q L + LQ+QL +
Sbjct: 1312 TNLEDIDVNHKSK-----LSSLQDLE-----KTKLEEQVQELESLISSLQQQLKE----T 1357
Query: 1072 QARHEAQVELLLHRQRDLGDSKSGLVSSSSSPVVVQHSVASQASAKAEPRRIQELYLSEK 1131
+ +EA++ L R L + S S V V S +++ +R K
Sbjct: 1358 EQNYEAEIHCLQKR----------LQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVK 1407
Query: 1132 ENVGPSCHLIIPTFQDKSLSFP-QHSLAQQENLTIL---QEQSQIQRVILGAKEGTQEFV 1187
+N+ D ++ F + + ++ N+ L Q Q Q++ +
Sbjct: 1408 KNI------------DGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAF 1455
Query: 1188 HTESELEKRISSEQTGTSSSLS----------QVDESERFQECISIKSDSTIPLSHPKIP 1237
++EL RIS + T+SS +E + Q+ I ++ T+
Sbjct: 1456 AQQTEL-SRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVD------- 1507
Query: 1238 RCQERLLRVSQHMLPLQDNLEEHQAWLDTEKEAFHFSQKTQE--NTSSEQTGSSS---FI 1292
++ + PL L EH + H ++++ T SE+ S +
Sbjct: 1508 ------VKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIV 1561
Query: 1293 PQLV--QLSFTSLASAESGTILEPLFTESESKIFSSHLQIPQLQDRLLRISQLIQPQ--- 1347
Q + ++S +S+ ++ + E + ++ + Q Q LLR + + Q +
Sbjct: 1562 RQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQY-QEHQQATELLRQAHMRQMERQR 1620
Query: 1348 ------QDNLKALQEQLA-----------TQREAIILARQEAREELLLHQSE---WEGRI 1387
Q+ +K L QLA ++RE ++L EA ++L L E E R
Sbjct: 1621 EDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRN 1680
Query: 1388 SPEQVDTSSLPLVPQHSFASLPLNESERNQEPCSINSDNIVSSGHSEIPTLPDGLLGLSH 1447
S Q + Q E E +++P + + I+S+ + + LL
Sbjct: 1681 SSTQTQNGN---ENQGEVEEQTFKEKELDRKPEDVPPE-ILSNERYALQKANNRLL---K 1733
Query: 1448 LVLPQQDNLIALEEHLHAQT-DFLPSIEKTQKELVL---------SKPCKFEEKVS-SEH 1496
++L A+EE + L K+Q L K C EE ++
Sbjct: 1734 ILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDE 1793
Query: 1497 FIQSHHGD----------LQALQQQLDTQKKAIRS------IQEVQEELLLQRLSELEKR 1540
I S+ G + ++ + ++ +RS I EEL+L S L+
Sbjct: 1794 SIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAA 1853
Query: 1541 VSS--EQVC-SSSFVSQVPVADSERTQKSFPTKSNDTLPSSHREIPRLQDRLLSLSKPIL 1597
V E + +SS + V +E ++SF K T +E L++RL S+
Sbjct: 1854 VEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQE--ELRERLHEESR--- 1908
Query: 1598 PQQDNMTAQLDAQREVMYSYEKPQEELSLNKQRKLNKSESAEHTIPSLFLPKETEHSFIP 1657
++ + +L V+ Y +E +L +++ K++ + L +
Sbjct: 1909 -AREQLAVELSKAEGVIDGY---ADEKTLFERQIQEKTDIIDRLEQELLC---ASNRLQE 1961
Query: 1658 LPFAEAKPKSTCELYSSQNEHAAPPSNPV---IPGFQDRLLSFSQSVLTQQDNL--GLQK 1712
L + + + EL S Q E + PV + ++L+ V Q + + LQK
Sbjct: 1962 LEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQK 2021
Query: 1713 Q-----LDLQREVLHYSQKAQEKL-----LVQRQTALQQQIQKHEETLKDFFKDSQISKP 1762
Q +D++ +V + + QEK L Q+ AL++Q++K + L + D + +
Sbjct: 2022 QVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERD 2081
Query: 1763 TVENDLKTQKMGQLRDWFPNTQDLAGNDQENIRHADRNNSDDNHLASEDTSAKQSGEHLE 1822
+ ++ QK+ Q P Q ++ + + + + SE +K E L+
Sbjct: 2082 VFQQEI--QKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSK---EQLQ 2136
Query: 1823 KDLGRRSSK 1831
+D+ R+ +
Sbjct: 2137 RDIQERNEE 2145
Score = 76.6 bits (187), Expect = 3e-13
Identities = 352/1891 (18%), Positives = 707/1891 (37%), Gaps = 298/1891 (15%)
Query: 27 ERRRKLRLLQVREQERDIALQIREDIKQRRNQQFTRLAEELRAEWEESQTQKIQNLEKLY 86
+ ++++ Q + +E+D L+ + K+ Q + L E+++ +E Q +K++N K
Sbjct: 265 QAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKV-YEMEQDKKVENSNK-- 321
Query: 87 LASLRSMGEGHRQAKENEPDLDALAQRAAERKRKADLRHKEALKVQKN-----QKEILLK 141
+ +E E ++ L + E ++K L K+ L Q++I+
Sbjct: 322 -----------EEIQEKETIIEELNTKIIEEEKKT-LELKDKLTTADKLLGELQEQIV-- 367
Query: 142 QKTWHIKARKEALLVEKERSAKITSLPPPPPTLFENIEVKRISAVKTNSSTYHHLHT--- 198
QK IK K L K++ + + E+K++ +H +
Sbjct: 368 QKNQEIKNMKLELTNSKQKERQSSE------------EIKQLMGTVEELQKRNHKDSQFE 415
Query: 199 --FVNR-ETDTKRPDARLAAEEEAKRLEELQKQAAQERMERFEKAHVRGFQAMKKIHLAQ 255
V R E +T+R +L AE L+E+ Q + + + H+ + MK H +
Sbjct: 416 TDIVQRMEQETQRKLEQLRAE-----LDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGE 470
Query: 256 NQEKLMKELKQLQQEDLARRRQTVAQMPPQLVELPYKRSE---MKEDWQRELEFAFEDMY 312
+ L ED + M + EL K + KE + EL E+
Sbjct: 471 MENALRSYSNITVNED------QIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKC 524
Query: 313 NADRKVKGNLI--LHLEPEPLPTVTNQIQDEELDLSMEQENLGAAEDLPVTEAEICS-SE 369
R+++ +L+ L E + I ++E L+ ++L EDL +AEI S SE
Sbjct: 525 ALQRQLE-DLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDL---KAEIVSASE 580
Query: 370 TDVPLVMKTQQIPSKVLFKKLLNKIRSQKSLWTIKSMSEDESEMITTVSEIESKAPTVES 429
+ L +K + + +K L + +K+ + M+E + E++ + +
Sbjct: 581 SRKELELKHEAEVTN--YKIKLEMLEKEKNA-VLDRMAESQ----------EAELERLRT 627
Query: 430 GTIASKERTLSSGQEQVVESDTLTIES--GPLASEDKPLSCGTNSGKEQEINE------- 480
+ S E LS +E + + IE L K G + Q+I
Sbjct: 628 QLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDN 687
Query: 481 --TLPITTVAQSSVLLHPQEAAARIRMSARQKQIMEIEEQKQKQLELLEQIEQQKLRLET 538
T + + S L Q++ + QI E+ QK++E+L Q E++K LE
Sbjct: 688 LITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINEL----QKEIEILRQEEKEKGTLEQ 743
Query: 539 DCFRAQLEEEKRKKTQPTGVGIAPASCPVISDEDSHRQMIRNYQHQLLQQNRLHRQSVET 598
+ QL+ E +K + E+S ++++ + L ++H +
Sbjct: 744 EVQELQLKTELLEKQMKEKENDLQEKFAQLEAENS---ILKDEKKTLEDMLKIHTPVSQE 800
Query: 599 ARKQLLEYQTMLKGRCPSVSAPSLITDSVISVPSWKSERPTAISEHWDQGQRLKLSPNKY 658
R L+ S S DSV W+ E I E+ D K
Sbjct: 801 ERLIFLD------------SIKSKSKDSV-----WEKEIEILIEENEDL---------KQ 834
Query: 659 QPIQPIQTSKLEQDHFQVARQN---HFPQRQVETTETLRASDILTN-------------Q 702
Q IQ + + +++ F A +N ++ + Q E L+ D L + +
Sbjct: 835 QCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLK 894
Query: 703 ALESQEHLRQFSQTETQQRDYKLVPKDSETLSRALSHDRQLISQDARKISETFGATTFQS 762
AL + HL++ + T + + + +D ++ L +++ +D ++ E T +
Sbjct: 895 ALNEELHLQRINPTTVKMKS-SVFDEDKTFVAETLEMG-EVVEKDTTELMEKLEVTKREK 952
Query: 763 LESQQLFSENSENISYHLTEPSSFVPLVPQHSFSSLPVKVESGKIQEPFSAMSKSTVSTS 822
LE Q S+ SE + E S V V + +++ + V +
Sbjct: 953 LELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSC 1012
Query: 823 HSIISQMHDRPLLPSENITAQQGNMKALQEQLDLQKKVLQATQEAQEQLLLCKQKEVEQQ 882
+ +S + D + + +G++ + + + K++ + + E + + ++ + EQ
Sbjct: 1013 DTQVSSLLDGVVTMTSR--GAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQL 1070
Query: 883 TGLSVFLPLVTPDSSALLPSAKADLGRIQESSPTKNNIAVSSDHHVISQLQDKRLSLSQP 942
+ LP VT +SS ++ + P++N DK
Sbjct: 1071 --ILDHLPSVTKESS------------LRATQPSEN---------------DKLQKELNV 1101
Query: 943 ILSQQNNFKFLQEQLNIQKDSLQARREAQEVLYVHKQSELDRRVCSEQAEPSFPFQVAQH 1002
+ S+QN+ + E I + + Q Y+ ++E D+ +CS + E F +
Sbjct: 1102 LKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYM--ENEKDKALCSLKEELIFAQEEKIK 1159
Query: 1003 TFTSLPSADTKSGKIQEQHSSKSEKGLVSCQSDIPISQDGS------LSFLQQFLPLHDS 1056
+ + ++ K QE L+ + +S++ S S L ++
Sbjct: 1160 ELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALK 1219
Query: 1057 LKLLQEQLTKQRDTLQARHEAQVELLLHRQRDLGDSKSGLVSSSSSP----VVVQHSVAS 1112
++ E D + + +++ + +D ++ L++ + +V+Q ++
Sbjct: 1220 CEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSK 1279
Query: 1113 QASAKAEPRRIQ--ELYLSEKENVGPSCHLIIPTFQDKSLSFPQH-SLAQQENLTILQEQ 1169
+ + +++ E L ++E S H + +D ++ S Q T L+EQ
Sbjct: 1280 IWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQ 1339
Query: 1170 SQIQRVILGA-----KEGTQEFVHTESELEKRISSEQTGTSSSLSQVD-----ESERFQ- 1218
Q ++ + KE Q + L+KR+ + T VD ES+ +
Sbjct: 1340 VQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRT 1399
Query: 1219 ----ECISIKSDSTIPLSHPKIPRCQERLLRVSQHMLPLQDNLEEHQAWLDTEKEAFHFS 1274
C+ D TI S + + ++++ + Q+ LEE A + + F+
Sbjct: 1400 MYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQ--YQEQLEEEVAKVIVSM-SIAFA 1456
Query: 1275 QKTQ--------ENTSSEQTGSSSFIPQLVQLSFTSLASAESGTILEPLFT-----ESES 1321
Q+T+ ENT+S + + + Q Q F + ++ + T + E
Sbjct: 1457 QQTELSRISGGKENTASSKQAHA--VCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEF 1514
Query: 1322 KIFSSHL---------------QIPQLQDRLLRISQLIQPQQDNLKALQEQLATQREAII 1366
K S L IP+ +D +L IS+ + + Q + + I
Sbjct: 1515 KPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQ----SIHDEIS 1570
Query: 1367 LARQEAREELLLHQSEWEGR----ISPEQVDTSSLPLVPQHSFASLPLNESERNQ----- 1417
++ +A +L+L++ + E + Q + L+ Q + ++ Q
Sbjct: 1571 VSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEI 1630
Query: 1418 --------EPCSINSDNIVSSGHSEIPTLPDGLLGLSHLVLPQQDNLIALEEHLHAQT-- 1467
+ SI+++N+VS L + L L L L ++ L + QT
Sbjct: 1631 KRLNRQLAQRSSIDNENLVSERER---VLLEELEALKQLSLAGREKLCCELRNSSTQTQN 1687
Query: 1468 ---DFLPSIEKTQKELVLSKPCKFEEKVSSEHFIQSHHGDLQALQQQLDTQKKAIRSIQE 1524
+ E+T KE L + E V E + +A + L + +++
Sbjct: 1688 GNENQGEVEEQTFKEKELDRK---PEDVPPEILSNERYALQKANNRLLKILLEVVKTTAA 1744
Query: 1525 VQEELLLQRLSELEKRVSSEQVCSSSFVSQVPVADSERTQKSFPTKSNDTLPS-SHREIP 1583
V+E + L L++ S+ S + S+ + + +++++PS S ++P
Sbjct: 1745 VEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMP 1804
Query: 1584 RLQDRLLSLSKPILPQQDNMTAQLDAQREVMYSYEKPQEELSLNKQRKLNKS-----ESA 1638
R +++ + + ++ +L + EEL LN +L + E+
Sbjct: 1805 RND---INMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAI 1861
Query: 1639 EHTIPSLFLPKETEHSFIPLPF---AEAKPKSTCELYSSQNEH-----------AAPPSN 1684
T L K T+ + F EA C+ + H +
Sbjct: 1862 SETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAE 1921
Query: 1685 PVIPGFQDRLLSFSQSVLTQQDNLGLQKQLDLQREVLHYSQKAQEKLLVQRQTALQQQIQ 1744
VI G+ D F + + + D + L++E+L S + QE A QQQIQ
Sbjct: 1922 GVIDGYADEKTLFERQIQEKTDIID-----RLEQELLCASNRLQE------LEAEQQQIQ 1970
Query: 1745 KHEETLKDFFKDSQISKPTVENDL--KTQKM 1773
+ E L + + VE L +T+K+
Sbjct: 1971 EERELLSRQKEAMKAEAGPVEQQLLQETEKL 2001
Score = 67.8 bits (164), Expect = 1e-10
Identities = 310/1692 (18%), Positives = 670/1692 (39%), Gaps = 242/1692 (14%)
Query: 181 KRISAVKTNSSTYHHL---HTFVNRETDTKRPDAR--LAAEEEAKRLEELQKQAAQERME 235
K + A+ SS H T + RE+ ++ +A L +EE + + +A ++
Sbjct: 1856 KLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAV 1915
Query: 236 RFEKAH--VRGFQAMKKIHLAQNQEKLMKELKQLQQEDL--ARRRQTVAQMPPQLVELPY 291
KA + G+ K + Q QEK + +L+QE L + R Q + Q+ E
Sbjct: 1916 ELSKAEGVIDGYADEKTLFERQIQEKT-DIIDRLEQELLCASNRLQELEAEQQQIQEERE 1974
Query: 292 KRSEMKEDWQRELEFAFEDMYNADRKV-KGNLILHLEPEPL-PTVTNQIQDEELD----- 344
S KE + E + + K+ K L + + E + + Q++ E+D
Sbjct: 1975 LLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQV 2034
Query: 345 ---LSMEQENLGAAEDLPVTEAEICSSETDVPLVMKTQQIP---SKVLFKKLLNKIRSQ- 397
+ +EQE DL + + + Q I + +F++ + K+ Q
Sbjct: 2035 SRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQL 2094
Query: 398 KSLWTIKSMSEDESEMITTVSEIESKAPTVESGTIASKERTLSSGQEQVVESDTLTIESG 457
K + + +SE ++ + ++ + S + SKE+ QE+ E + L
Sbjct: 2095 KVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVR 2154
Query: 458 PLASEDKPLSCGTNSGKEQEINETLPITTVAQSSVLLHPQEAAARIRMSARQKQIMEIEE 517
L ++ L ++ ++ E + A+ + L Q A R + ++K+I +EE
Sbjct: 2155 EL---EQALLVSADTFQKVEDRKHFGAVE-AKPELSLEVQLQAERDAIDRKEKEITNLEE 2210
Query: 518 QKQKQLELLE----QIEQQKLRLE------TDCFRAQLEEEKRKKTQPTGVGIAPASCPV 567
Q ++ E LE +++Q ++LE T + +E K K +G+A
Sbjct: 2211 QLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDA 2270
Query: 568 ISDEDSHRQMIRNYQHQLLQQNRLHRQSVETARKQLLEYQTMLKGRCPSVSAPSLITDSV 627
+S +D H ++ Q++Q+ + ++ +Q+ + Q LK + TD+
Sbjct: 2271 MSTQDQH--VLFGKFAQIIQEKEVE---IDQLNEQVTKLQQQLK----------ITTDNK 2315
Query: 628 ISVPSWKSERPTAISEHWDQGQRLKLSPNKYQPIQPIQT--SKLEQDHFQVARQNHFPQR 685
+ + R + + N+ + I+ + KL+Q+ + ++
Sbjct: 2316 VIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAH 2375
Query: 686 QV-ETTETLR-------ASDILTNQALESQEHLRQFSQTETQQRDYKLVPKDSETLSRAL 737
+ E ++L+ A + Q +E+ F + ++ ++K+ E S L
Sbjct: 2376 SLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFS--L 2433
Query: 738 SHDRQLISQDARKISETFGATTFQSLESQQLFSENSENISY-HLTEPSSFVPLV-PQHSF 795
+R+ S+E Q ENS N++ HL++ + +V + +
Sbjct: 2434 KRERE-------------------SVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDAL 2474
Query: 796 SSLPVKVESGKIQEPFSAMSKSTVSTSHSIISQMHDRPLLPSENITAQQGNMKALQEQLD 855
SL E+ + F K ++ + + Q+ +T +K +QEQ
Sbjct: 2475 KSL----ENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQ 2530
Query: 856 -----LQKKVLQATQEAQEQLL--LCKQKEVEQQTGLSVFLPLVTPDSSALLPSAKADLG 908
LQKK++ + +E++ L Q ++E + F D+ + S++ +
Sbjct: 2531 FETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQ----DNQTI--SSEPERT 2584
Query: 909 RIQESSPTKNNIAVSSDHHVISQLQDKRLSLSQPILSQQNNFKFLQEQLNI-QKDSLQAR 967
IQ + + + + SD IS L + L ++ + +EQ+ I +K+ L+
Sbjct: 2585 NIQNLNQLRED-ELGSD---ISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKE 2640
Query: 968 REAQEVLYVHKQSELDRRVCSEQAEPSFPFQVAQHTFTSLPSADTKSGKIQEQHSSKSEK 1027
++ E+ + + +E +R ++ P +V + T T L ++ +SG E + ++E
Sbjct: 2641 KKLLELQKLLEGNEKKQREKEKKRSPQ-DVEVLKTT-TELFHSNEESGFFNELEALRAES 2698
Query: 1028 GLVSCQSDIPISQDGSLSFLQQFLPLHDSLKLLQEQLTKQRDTLQARHEAQVELLLHRQR 1087
V+ ++++ ++ + ++ L ++ LQ+ L++ RD L E L +
Sbjct: 2699 --VATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDET 2756
Query: 1088 DLGDSKSGLVSSSSSPVVVQHSVASQASAKAEPRRIQELYLSEKENVGPSCHLIIPTFQD 1147
++ +SK + P+ + S+ASQ + + +N G +L Q
Sbjct: 2757 EVQESKKACMFEPL-PIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINL-----QS 2810
Query: 1148 KSLSFPQHSLAQQ--ENLTILQEQSQIQRVILGAKEGTQ-EFVHTESELEKRISSEQTGT 1204
+ S + Q E + +QE + + + ++ ++ E + E + ++ E+ GT
Sbjct: 2811 ECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGT 2870
Query: 1205 SSSLSQVDESERFQECISIKSDSTIP-LSHPKIPRCQERLLRVSQHMLPLQDNLEEHQAW 1263
++ Q C+ K S+IP L+H + +E + + Q
Sbjct: 2871 LKAVIQ---------CLRSKEGSSIPELAHSDAYQTRE--------ICSSDSGSDWGQGI 2913
Query: 1264 LDTEKEAFHFSQKTQENTSSEQTGSSSFIPQLVQ--LSFTSLASAESGTILEPLFTESES 1321
T + F + + + S T S P+ ++ L + ++ E +++ E
Sbjct: 2914 YLTHSQGFDIASEGRGEESESATDS---FPKKIKGLLRAVHNEGMQVLSLTESPYSDGED 2970
Query: 1322 KIFSSHLQIPQLQDRLLRISQLIQPQQDNLKALQEQLATQREAIILARQEAREELLLHQS 1381
+ P L++R I+ + +LK L ++ QREA + ++ E S
Sbjct: 2971 HSIQQ-VSEPWLEERKAYINTI-----SSLKDLITKMQLQREAEVYDSSQSHESF----S 3020
Query: 1382 EWEGRISPEQVDTSSLPLVPQHSFASLPLNESERNQEPCSINSDNIVSSGHSEIPTL-PD 1440
+W G L L Q F ER+ ++++ +E+ L
Sbjct: 3021 DWRGE----------LLLALQQVFLE------ERSV---------LLAAFRTELTALGTT 3055
Query: 1441 GLLGLSHLVLPQQDNLIALEEHLHAQ----TDFLPSIEKTQKELVLSKPCKFEEKVSSEH 1496
+GL L LE+ + Q + ++K + +LS+ +++
Sbjct: 3056 DAVGL----------LNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRK 3105
Query: 1497 FIQSHHGDLQALQQQL---DTQKKAIRSIQ-EVQEELLLQRLSELEKRVSSEQVCSSSFV 1552
+ + Q+L + Q+K + ++ +V+ + R +EL++++SSE++ +
Sbjct: 3106 ITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELK 3165
Query: 1553 SQVPVADSERTQKSFPTKSNDTLPSSHREIPRLQDRLLSL---SKPILPQQDNMTAQLDA 1609
S++ +T+ T TL + H+ + L+ L + + + D + ++
Sbjct: 3166 SEL-----AQTKLELET----TLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKK 3216
Query: 1610 QREVMYSYEKPQEELSLNKQRKLNKSESAEHTIPS-----LFLPKETEHSFIPLPFAEAK 1664
RE+ ++ EK + +L +++R + E + ++ S L L E L ++ K
Sbjct: 3217 SRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQK 3276
Query: 1665 PKSTCELYSSQNEHAAPPSNPVIPGFQDRLLSFSQSVLTQQDNLGLQKQLDLQREVLHYS 1724
+S LY +Q S + ++L S+ V ++ + L ++ +L ++
Sbjct: 3277 IESQRMLYDAQ------LSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSD 3330
Query: 1725 QKAQ-------EKLLVQRQTALQQ----------QIQKHE----ETLKDFFKDSQISKPT 1763
Q E LL + Q L++ + +K++ +T + KD Q+ + T
Sbjct: 3331 GTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKT 3390
Query: 1764 VENDLKTQKMGQ 1775
++ + + GQ
Sbjct: 3391 LQTEQEANTEGQ 3402
Score = 65.1 bits (157), Expect = 9e-10
Identities = 203/1061 (19%), Positives = 419/1061 (39%), Gaps = 167/1061 (15%)
Query: 339 QDEELDLSMEQENLGAAEDLPVTEAEICSSETDVPLVMKTQQIPSKVLFKKLLNKIRSQK 398
++EEL L++ A E L +E SS+ + V +T+ + F++ S K
Sbjct: 1838 ENEELMLNISSRLQAAVEKLLEAISET-SSQLEHAKVTQTELMRES--FRQKQEATESLK 1894
Query: 399 SLWTIKSMSEDESEMITTVSEIESKAPTVESGTIASKERTLSSGQEQVVESDTLTIESGP 458
++ +ES ++ SKA V G + E+TL E+ ++ T I+
Sbjct: 1895 CQEELRERLHEESRAREQLAVELSKAEGVIDGY--ADEKTLF---ERQIQEKTDIIDR-- 1947
Query: 459 LASEDKPLSCGTNSGKEQEINETLPITTVAQSSVLLHPQEAAARIRMSARQKQIMEIEEQ 518
++ L C +N +E E + Q+ + +RQK+ M+ E
Sbjct: 1948 ---LEQELLCASNRLQELEAEQ----------------QQIQEERELLSRQKEAMKAEAG 1988
Query: 519 KQKQLELLEQIEQQKLRLETDCFRAQLEEEKRKKTQPTGVGIAPASCPVISDEDSHRQMI 578
+Q L E + K +LE C ++ ++ +K+ + + + I E +
Sbjct: 1989 PVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTEL 2048
Query: 579 RNYQHQLLQQNRLHRQSVETARKQLLEYQTMLKGRCPSVSAPSLITDSVISVPSWKSERP 638
+ L QQN+ + +E RK L+ Q + + + ER
Sbjct: 2049 MD----LRQQNQALEKQLEKMRK-FLDEQAIDR----------------------EHERD 2081
Query: 639 TAISEHWDQGQRLKLSPNKYQPIQPIQTSKLEQDHFQVARQNHFPQRQVETTETLRASDI 698
E Q+LK+ P ++QPI QT ++EQ NH ++ + +E L + +
Sbjct: 2082 VFQQEIQKLEQQLKVVP-RFQPISEHQTREVEQ------LANHLKEKTDKCSELLLSKEQ 2134
Query: 699 LTNQALESQEHLRQ------------------FSQTETQQRDYKLVPKDSETLSRALSHD 740
L E E + + F + E ++ + K +L L +
Sbjct: 2135 LQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAE 2194
Query: 741 RQLISQDARKISETFGATTFQSLESQ-QLFSENSENISYHLTEPSSFVPLVPQHSFSSLP 799
R I + ++I+ +LE Q + F E EN + + + + + + S + L
Sbjct: 2195 RDAIDRKEKEIT---------NLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQ 2245
Query: 800 VKVESGKIQEPFSAMSKSTVSTSHSIISQMHDR--------PLLPSENITAQQGN--MKA 849
+ K+ + M K ++ S D+ ++ + + Q N +
Sbjct: 2246 ELEQENKLFK--DDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTK 2303
Query: 850 LQEQLDL--------QKKVLQATQEAQEQLLLCKQKEVEQQTGLSVFLPLVTPDSSALLP 901
LQ+QL + +K L E Q + L+ Q+ V++ + + ++
Sbjct: 2304 LQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEI------EQLNEVIE 2357
Query: 902 SAKADLGRI-QESSPTKNNIAVSSD--HHVISQLQDKRLSLSQPILSQQNNFKFLQEQLN 958
+ +L I Q++S ++++ +D H + + ++L+L Q + + F++ L
Sbjct: 2358 KLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVL- 2416
Query: 959 IQKDSLQARREAQEVLYVHKQSELDRRVCSEQAEPSFPFQVA-QHTFTSLPSADTKSGKI 1017
++ + + + QE+ + ++ E ++ Q+ P VA H P + +
Sbjct: 2417 -KETNFKMNQLTQELFSLKRERESVEKI---QSIPENSVNVAIDHLSKDKPELEV----V 2468
Query: 1018 QEQHSSKSEKGLVSCQSDIPISQDGSLSFLQQFLPLHDSLKLLQEQLT---KQRDTLQAR 1074
+ + KS + +S + ++ + L L ++ +LT KQ +Q +
Sbjct: 2469 LTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQ 2528
Query: 1075 HEAQVELL----LHRQRDLGDS-KSGLVSSSSSPVVVQHSVASQ----ASAKAEPRRIQE 1125
+ + E+L ++ Q+ + + + LVS V +++ Q S++ E IQ
Sbjct: 2529 GQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQN 2588
Query: 1126 LYLSEKENVG---PSCHLIIPTFQDKSLSFPQHSLAQQENLTILQEQ-SQIQRVILGAKE 1181
L ++ +G + L I + + + + ++E + I ++ + ++ +L ++
Sbjct: 2589 LNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQK 2648
Query: 1182 GTQEFVHTESELEKRISSEQTGTSSSLSQV----DESERFQECISIKSDSTIPLSH---- 1233
+ + E EK+ S + + +++ +ES F E +++++S +
Sbjct: 2649 LLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASY 2708
Query: 1234 -PKIPRCQERLLRVSQHMLPLQDNLEEHQAWLDTEKEAFHFSQKTQENTSSEQTGSSSFI 1292
K + QE LL +M LQ +L + + L KE +K E E + F
Sbjct: 2709 KEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFE 2768
Query: 1293 PQLVQLSFTSLASAESGTILEPLFTESESKIFSSHLQIPQL 1333
P ++LS S+AS GT+ KI SS+ Q PQ+
Sbjct: 2769 PLPIKLS-KSIASQTDGTL----------KISSSN-QTPQI 2797
Score = 60.8 bits (146), Expect = 2e-08
Identities = 204/1107 (18%), Positives = 431/1107 (38%), Gaps = 200/1107 (18%)
Query: 38 REQERDIALQIREDIKQRRNQQFTRLAEELRAEWEESQ--------------------TQ 77
++QE +L+ +E++++R +++ +R E+L E +++ T
Sbjct: 1885 QKQEATESLKCQEELRERLHEE-SRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTD 1943
Query: 78 KIQNLEKLYLASLRSMGEGHRQAKENEPDLDALAQRAAERKRKADLRHKEALKVQKNQKE 137
I LE+ L + + E L+A Q+ E +R+ R KEA+K + E
Sbjct: 1944 IIDRLEQELLCASNRLQE-----------LEAEQQQIQE-ERELLSRQKEAMKAEAGPVE 1991
Query: 138 ILLKQKTWHIKARKEALLVEKERSAKITSLPPPPPTLFENIEVKRISAVKTNSSTYHHLH 197
L Q+T K KE L V+ + L K++ A++ +
Sbjct: 1992 QQLLQET--EKLMKEKLEVQCQAEKVRDDLQ------------KQVKALEIDVEEQVSRF 2037
Query: 198 TFVNRETDTKRPDARLAAEEEAKRLEELQKQAAQERMERFEKAHVRGFQAMKKIHLAQNQ 257
+ +E +T+ D R + K+LE+++K ++ ++R + V FQ Q
Sbjct: 2038 IELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDV--FQ--------QEI 2087
Query: 258 EKLMKELKQLQQEDLARRRQT--VAQMPPQLVELPYKRSEM---KEDWQRELEFAFEDMY 312
+KL ++LK + + QT V Q+ L E K SE+ KE QR+++ E++
Sbjct: 2088 QKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIE 2147
Query: 313 NADRKVKGNLILHLEPEPLPTVTNQIQDEELDLSMEQENLGAAEDLPVTEAEICSSETDV 372
+ +V+ LE + L + Q E ++++ GA E P E+
Sbjct: 2148 KLEFRVR-----ELE-QALLVSADTFQKVE-----DRKHFGAVEAKPELSLEVQLQAERD 2196
Query: 373 PLVMKTQQIPSKVLFKKLLNKIRSQKSLWTIKSMSEDESEMITTVSEIESKAPTVESGTI 432
+ K ++I + ++ L + R + +E + + EI+ K T +
Sbjct: 2197 AIDRKEKEITN---LEEQLEQFREE------LENKNEEVQQLHMQLEIQKKESTTRLQEL 2247
Query: 433 ASKERTLSSGQEQ----VVESDTLTIES-----GPLAS--EDKPLSCGTNSGKEQEINET 481
+ + E+ + ESD ++ + G A ++K + + + ++ +
Sbjct: 2248 EQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQ 2307
Query: 482 LPITT----VAQSSVLLHPQEAAARIRMSARQKQIMEIEEQKQKQLELLEQIEQQKLRL- 536
L ITT + + + L+ E MS ++ EE+ ++ E++E+++Q+ +
Sbjct: 2308 LKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIG 2367
Query: 537 -ETDCFRAQLEEEKRKKTQPTGVGIAPASCPVISDEDSHRQMIRNYQHQLLQQNRLHRQS 595
+T L EE V VI+++ + Q + ++ + +++
Sbjct: 2368 QKTSMNAHSLSEEADSLKHQLDV--------VIAEKLALEQQVETANEEMTFMKNVLKET 2419
Query: 596 VETARKQLLEYQTMLKGRCPSVSAPSLITDSVISV-----PSWKSERPTAISEHWDQGQR 650
QL + LK SV I ++ ++V K E ++E
Sbjct: 2420 -NFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTE-----DA 2473
Query: 651 LKLSPNKYQPIQPIQTSKLEQDHFQVARQN------HFPQRQVETTETLRASDILTNQAL 704
LK N Q +F+ +N + R ++ T+ A D+ Q
Sbjct: 2474 LKSLEN--------------QTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCY 2519
Query: 705 ESQEHLRQFSQTETQQRDYKLVPKD---SETLSRALSHDRQLISQDARKISETFGATTFQ 761
+ + +++ Q ET+ K+V E ++ AL QL +
Sbjct: 2520 KQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQL-----------------E 2562
Query: 762 SLESQQLFSENSENISYHLTEPSSFVPLVPQHSFSSLPVKVESGKIQEPFSAMSKSTVST 821
+++ F ++++ IS P+ + ++ ++ SA++ +S
Sbjct: 2563 AVQEYAKFCQDNQTISSE-----------PERTNIQNLNQLREDELGSDISALT-LRISE 2610
Query: 822 SHSIISQMHDRPLLPSENITAQQGNMKALQEQLDLQKKVLQATQEAQEQLLLCKQKEVEQ 881
S + +MH +L E + + N+ +++L +K+L+ ++ KQ+E E+
Sbjct: 2611 LESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEK--------KQREKEK 2662
Query: 882 QTGLSVFLPLVTPDSSALLPSAKADLGRIQESSPTKNNIAVSSDHHV-----ISQLQDKR 936
+ +P +L + +L E S N + V ++ ++K
Sbjct: 2663 KR---------SPQDVEVLKTT-TELFHSNEESGFFNELEALRAESVATKAELASYKEKA 2712
Query: 937 LSLSQPILSQQNNFKFLQEQLNIQKDSLQARREAQEVLYVHKQSELDRRVCSEQAEPSFP 996
L + +L ++ N LQ+ L+ +D L +E +L ++E+ + EP P
Sbjct: 2713 EKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEP-LP 2771
Query: 997 FQVAQHTFTSLPSADTKSGKIQEQHSSKSEKGL-VSCQSDIPISQDGSLSFLQQFLPLHD 1055
++++ + S Q G+ ++ QS+ S + + QF +
Sbjct: 2772 IKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSE--CSSEEVTEIISQFT---E 2826
Query: 1056 SLKLLQEQLTKQRDTLQARHEAQVELL 1082
++ +QE + +++RH ++ E L
Sbjct: 2827 KIEKMQELHAAEILDMESRHISETETL 2853
Score = 58.9 bits (141), Expect = 6e-08
Identities = 281/1512 (18%), Positives = 573/1512 (37%), Gaps = 200/1512 (13%)
Query: 405 SMSEDESEMITTVSEIESKAPTVESGTIASKERTLSSG------QEQVVESDTLTIESGP 458
S E+ E T + E+ +K E T+ K++ ++ QEQ+V+ +
Sbjct: 319 SNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQ------- 371
Query: 459 LASEDKPLSCGTNSGKEQEINETLP--ITTVAQSSVLLHPQEAAARIRMSARQKQIMEIE 516
++ L + KE++ +E + + TV + H + Q ME E
Sbjct: 372 -EIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDS-----QFETDIVQRMEQE 425
Query: 517 EQK---QKQLELLEQIEQQKLRLETDCFR---AQLEEEK-RKKTQPTGVGIAPASCPVIS 569
Q+ Q + EL E QQ ++++ + R AQ+EE K R K + + ++ V
Sbjct: 426 TQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNE 485
Query: 570 DEDSHRQMIRNYQHQLLQQNRLHRQSVETARKQLLEYQTMLKGRCPSVSAPSLITDSVIS 629
D+ + N + LQ ++ ++ +LE + L+ + L+ + S
Sbjct: 486 DQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLED-----LVEELSFS 540
Query: 630 VPSWKSERPTAISEHWDQGQRLKLSPNKYQPIQPIQTSKLEQDHFQVARQNHFPQRQVET 689
+ R T I+E Q KL+ ++ + ++ K E +R+ + + E
Sbjct: 541 REQIQRARQT-IAE-----QESKLN-EAHKSLSTVEDLKAEIVSASESRKELELKHEAEV 593
Query: 690 TETLRASDILTNQALESQEHLRQFSQTETQQRDYKLVPKDSETLSRALSHDRQLISQ-DA 748
T ++L + + + + + E ++ +L+ E LS+ L D ++ + +
Sbjct: 594 TNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSK-LKEDLEIEHRINI 652
Query: 749 RKISETFGATTFQSLESQQLFSENSENISYHLTEPSSFVPLVPQ-----HSFSSLPVKVE 803
K+ + G Q ++ Q +E S+ I E + + Q L +
Sbjct: 653 EKLKDNLGIHYKQQIDGLQ--NEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLV 710
Query: 804 SGKIQEPFSAMSKSTVSTSHSIISQMHDRPLLPSENITAQQGNMKALQEQL-----DLQK 858
+ K +E + + + I+ Q + + Q + L++Q+ DLQ+
Sbjct: 711 NSKSEE--MTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQE 768
Query: 859 KVLQATQEAQEQLLLCKQKEVEQQTGLSVFLPLVTPDSSALLPSAKADLGRIQESSPTKN 918
K Q EA+ +L ++K +E L + P+ + L S K+ + S +
Sbjct: 769 KFAQL--EAENSILKDEKKTLEDM--LKIHTPVSQEERLIFLDSIKSK----SKDSVWEK 820
Query: 919 NIAVSSDHHVISQLQDKRLSLSQPILSQQNNFKFLQEQLNIQ--------------KDSL 964
I + + + L+ + + L++ I Q+N F F ++ + KD L
Sbjct: 821 EIEILIEEN--EDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDL 878
Query: 965 QARREAQEVLYVHKQSELDRRVCSEQAEPSFPFQVAQHTF---TSLPSADTKSGKIQEQH 1021
+ + QE+ Y K L+ + ++ P+ ++ F + + + G++ E+
Sbjct: 879 EDSKNKQELEYKSKLKALNEELHLQRINPT-TVKMKSSVFDEDKTFVAETLEMGEVVEKD 937
Query: 1022 SSK-SEKGLVSCQSDIPISQDGSLSFLQQFLPLHDSLKLLQEQ---LTKQRDTLQARHEA 1077
+++ EK V+ + + +SQ S +Q H + L E+ L ++++ + R
Sbjct: 938 TTELMEKLEVTKREKLELSQRLS-DLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRE 996
Query: 1078 QVELLLHRQRDLGDSKSGLVSSSSSPVVVQHSVASQASAKAEPRRIQELYLSEKENVGPS 1137
++ H + + S VSS VV S ++ S ++ G
Sbjct: 997 LEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVS-----------KVNKSFGEE 1045
Query: 1138 CHLIIPTFQDKSLSFPQHSLAQQENLTILQEQSQIQRVILGAKEGTQEF----------- 1186
+++ +DK +SF EN+T+ +E Q Q ++ T+E
Sbjct: 1046 SKIMV---EDK-VSF--------ENMTVGEESKQEQLILDHLPSVTKESSLRATQPSEND 1093
Query: 1187 -------VHTESELEKRISSEQTGTSSSLSQVDESERFQECISIKSDSTIPLSHPKIPRC 1239
V + + R+ E SL ++ +E + + D + ++
Sbjct: 1094 KLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFA 1153
Query: 1240 QERLLRVSQHMLPLQDNLEEHQAWLDTEKEAFHFSQKTQENTSSEQTGSSSFIPQLVQLS 1299
QE ++ Q + L+ + Q D K K Q+ S E + + ++
Sbjct: 1154 QEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEY 1213
Query: 1300 FTSLASAESGTILEPLFTESESKIFSSHLQIPQLQDRLLRISQLIQPQQDNLKALQEQLA 1359
+T E + S + S + P+LQD +Q Q+N+ L ++
Sbjct: 1214 YTPALKCEVNA-----EDKENSGDYISENEDPELQDYRYE----VQDFQENMHTLLNKVT 1264
Query: 1360 TQREAIILARQEAREELLLHQSEWEGRISPEQVDTSSLPL----VPQHSFASLPLNESER 1415
E +LL+ Q+ +I +Q D L +P+ L ++
Sbjct: 1265 -----------EEYNKLLVLQTRL-SKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMT 1312
Query: 1416 NQEPCSINSDNIVSSGHS-EIPTLPDGLLGLSHLVLPQQDNLIALEEHLHAQTDFLPSIE 1474
N E +N + +SS E L + + L L+ Q L E++ A+ L
Sbjct: 1313 NLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRL 1372
Query: 1475 KTQKELVLSKPCKFEEKVSSEHFIQSHHGDLQALQQQLDTQKKAIRSIQE------VQEE 1528
+ E + + V +E D Q KK I E V+EE
Sbjct: 1373 QAVSESTVPPSLPVDSVVITE-------SDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEE 1425
Query: 1529 LLLQRLSELEKRVSSEQVCSSSFVSQVPVADSERTQKSFPTKSNDTLPSSHREIPRLQDR 1588
+ +L E + + E+ + VS + +A +++T+ S + + SS + Q
Sbjct: 1426 TNIVKLLEKQYQEQLEEEVAKVIVS-MSIAFAQQTELSRISGGKENTASSKQAHAVCQQE 1484
Query: 1589 LLSLSKPILPQQDNMTAQLDAQREVMYSYE-KPQEELSLNKQRKLNKSESAEHTIPSLFL 1647
++ L QD + Q +V + E KP + +++ S S H IP
Sbjct: 1485 QHYFNEMKL-SQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPE--- 1540
Query: 1648 PKETEHSFIPLPFAEAKPKSTCELYSSQNEHAAPPSNPVIPGFQDRLLSFSQSVLTQQDN 1707
C L S+ + + V D +S S ++Q
Sbjct: 1541 ------------------SKDCVLTISEEMFSKDKTFIVRQSIHDE-ISVSSMDASRQLM 1581
Query: 1708 LGLQKQLDLQREVLHYSQKAQEKLLVQRQTALQQQIQKHE--ETLKDFFK--DSQIS-KP 1762
L ++ D+++E++ Q+ Q+ + RQ ++Q ++ E E L++ K + Q++ +
Sbjct: 1582 LNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRS 1641
Query: 1763 TVEND-LKTQKMGQLRDWFPNTQDLAGNDQENIRHADRNNSDDNHLASEDTSAKQSGEHL 1821
+++N+ L +++ L + + L+ +E + RN+S +E+ +
Sbjct: 1642 SIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFK 1701
Query: 1822 EKDLGRRSSKPP 1833
EK+L R+ P
Sbjct: 1702 EKELDRKPEDVP 1713
Score = 58.2 bits (139), Expect = 1e-07
Identities = 325/1683 (19%), Positives = 646/1683 (38%), Gaps = 278/1683 (16%)
Query: 226 QKQAAQERMERFEKAHVRGFQAMKKIHLAQNQEKLMKELKQLQQEDLARRRQTVAQMPPQ 285
Q Q Q+ E +AH+R + + ++QE+L +E+K+L ++ LA+R
Sbjct: 1597 QYQEHQQATELLRQAHMRQMERQR-----EDQEQLQEEIKRLNRQ-LAQRSS-------- 1642
Query: 286 LVELPYKRSEMKEDWQRELEFAFEDMYNADRKVKGNLILHLEPEPLPTVTNQIQDEELDL 345
++ SE + ELE A + + A R+ + ++++
Sbjct: 1643 -IDNENLVSERERVLLEELE-ALKQLSLAGRE---------------KLCCELRNSSTQT 1685
Query: 346 SMEQENLGAAEDLPVTEAEICSSETDVPLVMKTQ-----QIPSKVLFKKLLNKIRSQKSL 400
EN G E+ E E+ DVP + + Q + L K LL ++
Sbjct: 1686 QNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVK----- 1740
Query: 401 WTIKSMSEDESEMITTVSEIESKAPTVESGTIASKERTLSSGQEQVVESDT-LTIESGPL 459
T ++ E + + + SK+ + S ++ + +S + V E T +T ES P
Sbjct: 1741 -TTAAVEETIGRHVLGILDRSSKSQS--SASLIWRSEAEASVKSCVHEEHTRVTDESIPS 1797
Query: 460 AS-EDKPLSCGTNSGKEQEINETLPITTVAQ--SSVLLHPQEAAARIRMSARQKQIME-- 514
S D P + K E L V + + P+ + +S+R + +E
Sbjct: 1798 YSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKL 1857
Query: 515 ----------IEEQKQKQLELLEQIEQQK------LRLETDCFRAQLEEEKRKKTQPTGV 558
+E K Q EL+ + +QK L+ + + R +L EE R + Q V
Sbjct: 1858 LEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEE-LRERLHEESRAREQ-LAV 1915
Query: 559 GIAPASCPVISDEDSHRQMIRNYQHQ-----------LLQQNRLHRQSVETARKQLLEYQ 607
++ A + D R Q + L NRL Q +E ++Q+ E +
Sbjct: 1916 ELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRL--QELEAEQQQIQEER 1973
Query: 608 TMLKGRCPSVSAPSLITDSVISVPSWKSERPTAISEHWD-QGQRLKLSPNKYQPIQPIQT 666
+L + ++ A + + + E + E + Q Q K+ + + ++ ++
Sbjct: 1974 ELLSRQKEAMKAEAGPVEQQLL-----QETEKLMKEKLEVQCQAEKVRDDLQKQVKALEI 2028
Query: 667 SKLEQDHFQVARQNHFPQRQVETTETLRASDILTNQALESQ-EHLRQFSQTETQQRDYKL 725
EQ V+R Q + LR NQALE Q E +R+F + R+
Sbjct: 2029 DVEEQ----VSRFIELEQEKNTELMDLRQQ----NQALEKQLEKMRKFLDEQAIDRE--- 2077
Query: 726 VPKDSETLSRALSHDRQLISQDARKISETFGATT-FQSLESQQLFSENSENISYHL---T 781
H+R + Q+ +K+ + FQ + Q + E ++ HL T
Sbjct: 2078 -------------HERDVFQQEIQKLEQQLKVVPRFQPISEHQ--TREVEQLANHLKEKT 2122
Query: 782 EPSSFVPLVPQHSFSSLPVKVESGKIQEPFSAMSKSTVSTSHSIISQMHDRP---LLPSE 838
+ S + L + + + E + E + + S ++ DR + ++
Sbjct: 2123 DKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAK 2182
Query: 839 NITAQQGNMKALQEQLDLQKKVLQATQEAQEQL---LLCKQKEVEQQTGLSVFLPLVTPD 895
+ + ++A ++ +D ++K + +E EQ L K +EV+Q L + L + +
Sbjct: 2183 PELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQ---LHMQLEIQKKE 2239
Query: 896 SSALLPSAKADLGRIQESSPTKNNIAV-------SSDHHVI-----SQLQDKRLSLSQPI 943
S+ L + + ++ + K +A+ + D HV+ +Q+K + + Q
Sbjct: 2240 STTRLQELEQE-NKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQ-- 2296
Query: 944 LSQQNNFKFLQEQLNIQKDS--LQARREAQEVLYVHKQSELDRRVC---SEQAEPSFPFQ 998
L++Q LQ+QL I D+ ++ + E L + + + C + + E +
Sbjct: 2297 LNEQ--VTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNE 2354
Query: 999 VAQHTFTSLPSADTKSGKIQEQHSSKSEKGLVSCQSDIPISQDGSLSFLQQFLPLHDSLK 1058
V + L + K+ HS E + Q D+ I++ L L ++
Sbjct: 2355 VIEKLQQELANIGQKTS--MNAHSLSEEADSLKHQLDVVIAEK---------LALEQQVE 2403
Query: 1059 LLQEQLTKQRDTLQARHEAQVELL-----LHRQRDLGDSKSGLVSSSSSPVVVQHSVASQ 1113
E++T ++ L+ + +L L R+R+ + K + +S V + H +
Sbjct: 2404 TANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVE-KIQSIPENSVNVAIDHLSKDK 2462
Query: 1114 ASAKA-------EPRRIQELYLSEKEN-VGPSCHLIIPTFQ-DKSLSFPQHSLAQ-QENL 1163
+ + Q + S +EN G +L Q + ++S L Q + +
Sbjct: 2463 PELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQI 2522
Query: 1164 TILQEQSQIQRVILGAKEGTQEFVHTESELEKRISSEQTGT----------SSSLSQVDE 1213
+QEQ Q + +L K + + E +S Q + ++S E
Sbjct: 2523 KDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPE 2582
Query: 1214 SERFQECISIKSD---STIPLSHPKIPRCQERLLRVSQHMLPLQDNLE-EHQAWLDTEKE 1269
Q ++ D S I +I + +++ + ++ ++ +E + L+ EK+
Sbjct: 2583 RTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKK 2642
Query: 1270 AFHFSQKTQENTSSEQTGSSSFIPQLVQLSFTSL----ASAESGTILEPLFTESESKIFS 1325
+ + N ++ PQ V++ T+ ++ ESG E +ES +
Sbjct: 2643 LLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAES--VA 2700
Query: 1326 SHLQIPQLQDRLLRISQLIQPQQDNLKALQEQLATQREAIILARQEAREELLLHQSEWEG 1385
+ ++ +++ ++ + + ++ N+ +LQ+ L+ R+ + A+++ +L + E E
Sbjct: 2701 TKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKL--SILEKEDETEV 2758
Query: 1386 RISPEQVDTSSLPLVPQHSFASLP---LNESERNQEP-CSINSDNIVSSGHSEIPTLPDG 1441
+ S + LP+ S AS L S NQ P + + I + SE +
Sbjct: 2759 QESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSS---- 2814
Query: 1442 LLGLSHLVLPQQDNLIALEEHLHAQTDFLPSIEKTQKELVLSKPCKFEEKVSSEH--FIQ 1499
EE + F IEK Q EL ++ E + SE +
Sbjct: 2815 ------------------EEVTEIISQFTEKIEKMQ-ELHAAEILDMESRHISETETLKR 2855
Query: 1500 SHHGDLQALQQQLDTQKKAIRSIQEVQEELLLQRLSELEKRVSSEQVCSSS--------- 1550
H+ +Q L+++ T K I+ ++ +E + L+ + + ++CSS
Sbjct: 2856 EHYVAVQLLKEECGTLKAVIQCLRS-KEGSSIPELAHSDA-YQTREICSSDSGSDWGQGI 2913
Query: 1551 ---------FVSQVPVADSERTQKSFPTKSNDTLPSSHREIPRLQDRLLSLSKPILPQQD 1601
S+ +SE SFP K L + H E ++LSL++ P D
Sbjct: 2914 YLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNE----GMQVLSLTES--PYSD 2967
Query: 1602 NMTAQLDAQREVMYSYEKPQEELSLNKQRKLNKSESAEHTIPSLFLPKETEHSFIPLPFA 1661
+S ++ E ++ +N S + I + L +E E +
Sbjct: 2968 GED----------HSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAE-VYDSSQSH 3016
Query: 1662 EAKPKSTCELYSSQNEHAAPPSNPVIPGFQDRLLSFSQSVLTQQDNLGLQKQLD--LQRE 1719
E+ EL + + + ++ F+ L + L D +GL L+ +Q +
Sbjct: 3017 ESFSDWRGELLLALQQVFLEERSVLLAAFRTEL-----TALGTTDAVGLLNCLEQRIQEQ 3071
Query: 1720 VLHYS------QKAQEKLLVQRQTALQQQIQKHEETLKDFFKDSQISKPTVENDLKTQKM 1773
+ Y QKA + L+ AL Q+ + TLK + + S+ +E +++ QK
Sbjct: 3072 GVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQ-QKQ 3130
Query: 1774 GQL 1776
Q+
Sbjct: 3131 SQM 3133
Score = 48.9 bits (115), Expect = 6e-05
Identities = 289/1536 (18%), Positives = 580/1536 (37%), Gaps = 258/1536 (16%)
Query: 255 QNQEKL---MKELKQLQQEDLARRRQTVAQMPPQLVELPYKRSEMKEDWQRELEFAFE-- 309
+ Q+KL +L Q +Q R+ Q+ Q P + + K S K D + +
Sbjct: 5 ERQKKLEAGKAKLAQFRQ----RKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQS 60
Query: 310 ---DMY-NADRKVKGNLILHLEPEPLPTVTNQIQDEELDLSMEQENLGAAEDLPVTEAEI 365
+MY N+ ++V+ +I P T+ + E+ S EQ E T A+
Sbjct: 61 QCNEMYINSSQRVESTVI------PESTIMRTLHSGEIT-SHEQGFSVELESEISTTADD 113
Query: 366 CSSETD-VPLVMKTQQIPSKVLFKKLLNKIRSQKSLWTIKSMSEDESEMITTVSEIESKA 424
CSSE + VM+T + P+ +L ++ S ++ + + + + SE+ K
Sbjct: 114 CSSEVNGCSFVMRTGK-PTNLLREEEFGVDDS----YSEQGAQDSPTHLEMMESELAGKQ 168
Query: 425 PTVESGTIASKERTLSSGQE---QVVESDTLTIESGPLASEDKPLSCGTNSGKEQEINET 481
+E +E ++ G E Q+ E + + + ++ K++ + E
Sbjct: 169 HEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREF 228
Query: 482 LPITTVAQSSVLLHPQ-EAAARIRMSAR----------QKQIMEIEEQKQKQLELLEQIE 530
L +T +Q + Q +A+ +R S ++QI+ ++Q ++Q LLE +
Sbjct: 229 LELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQ 288
Query: 531 QQKLRLETDCFRAQLEEEKRKKTQPTGVGIAPASCPVISDEDSHRQMIRNYQHQLLQQNR 590
++K E + +EK K E + + N + +Q+
Sbjct: 289 KKK---EDFTMQISFLQEKIKVY-----------------EMEQDKKVENSNKEEIQEKE 328
Query: 591 LHRQSVETARKQLLEYQTMLKGRCPSVSAPSLITDSVISVPSWKSERPTAISEHWDQGQR 650
+ + T K + E + L+ + +A L+ + + E + +
Sbjct: 329 TIIEELNT--KIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQE---------IKNMK 377
Query: 651 LKLSPNKYQPIQPIQTSKLEQDHFQVARQNHFPQRQVETTETLRASDILTNQALESQEHL 710
L+L+ +K + Q + K + ++ + Q ET DI+ E+Q L
Sbjct: 378 LELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFET-------DIVQRMEQETQRKL 430
Query: 711 RQFSQTETQQRDYKLVPKDSETLSRALSHDRQLISQDARKISETFGATTFQSLESQQLFS 770
Q + ++V E + + H Q+ R E A L S +
Sbjct: 431 EQLRAELDEMYGQQIVQMKQELIRQ---HMAQMEEMKTRHKGEMENA-----LRSYSNIT 482
Query: 771 ENSENISYHLTEPSSFVPLVPQHSFSSLPVKVESGKIQEPFSAMSKSTVSTSHSIISQMH 830
N + I + + + +K E G I E A+ + +S
Sbjct: 483 VNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEE-LSFSR 541
Query: 831 DRPLLPSENITAQQGNM----KALQEQLDLQKKVLQATQEAQEQLLLCKQKEVEQQTGLS 886
++ + I Q+ + K+L DL+ +++ A+ E++++L L + EV T
Sbjct: 542 EQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSAS-ESRKELELKHEAEV---TNYK 597
Query: 887 VFLPLVTPDSSALL----PSAKADLGRI---------QESSPTKNNIAVSSDHHV-ISQL 932
+ L ++ + +A+L S +A+L R+ +E S K ++ + +H + I +L
Sbjct: 598 IKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEI--EHRINIEKL 655
Query: 933 QDK-RLSLSQPILSQQNNFKFLQEQLNIQKDSLQARREAQEVLYVHKQSELDRRVCSEQA 991
+D + Q I QN E + +KD+L ++ Q +L + K +L + + + ++
Sbjct: 656 KDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNL-ITKQNQLILEISKLKDLQQSLVNSKS 714
Query: 992 EPSFPFQVAQHTFTSLPSADTKSGKIQEQHSSKSEKGLVSCQSDIPISQDGSLSFLQQFL 1051
E Q+ + +I+ + EKG + Q+
Sbjct: 715 E-EMTLQI-----------NELQKEIEILRQEEKEKGTLE----------------QEVQ 746
Query: 1052 PLHDSLKLLQEQLTKQRDTLQ---ARHEAQVELLLHRQRDLGDS-KSGLVSSSSSPVVVQ 1107
L +LL++Q+ ++ + LQ A+ EA+ +L ++ L D K S ++
Sbjct: 747 ELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFL 806
Query: 1108 HSVASQASAKAEPRRIQELYLSEKENVGPSCHLIIPTFQDKSLSFPQHSLAQQENLTILQ 1167
S+ S++ + I E+ + E E++ C + + + +F S A++ Q
Sbjct: 807 DSIKSKSKDSVWEKEI-EILIEENEDLKQQCIQLNEEIEKQRNTF---SFAEKNFEVNYQ 862
Query: 1168 EQSQIQRVILGAKEGTQEFVHTESELE--------------KRISSEQTGTSSSLSQVDE 1213
E + +L K+ ++ + ELE +RI+ SS+ D+
Sbjct: 863 ELQEEYACLLKVKDDLED-SKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDK 921
Query: 1214 ---SERFQECISIKSDSTIPLSHPKIPRCQERLLRVSQHMLPLQDNL------------- 1257
+E + ++ D+T + K+ + L +SQ + L + L
Sbjct: 922 TFVAETLEMGEVVEKDTTELME--KLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEE 979
Query: 1258 ------EEHQAWLDTEKEAFHFSQKTQENTSSEQTGSSSFIPQLVQLSFTSLASAESGTI 1311
E+ Q L + + EN S T SS + +V + TS + S +
Sbjct: 980 VKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVV--TMTSRGAEGSVSK 1037
Query: 1312 LEPLFTESESKIFSSHLQIPQLQDRLLRISQLIQPQQDNLKALQEQL-ATQREAIILARQ 1370
+ F E ESKI ++D++ + + + + + + L + +E+ + A Q
Sbjct: 1038 VNKSFGE-ESKI--------MVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQ 1088
Query: 1371 -----EAREELLLHQSEWEGRISPEQVDTSSLPLV-PQHSFASLPLNESERNQEPCSINS 1424
+ ++EL + +SE + L LV H E+E+++ CS+
Sbjct: 1089 PSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKE 1148
Query: 1425 DNIVSSGHS----------EIPTLPDGLLGLS----HLVLPQQDNLIALEEHLHAQTDFL 1470
+ I + E+ T+ G HL++ + ++ E QT L
Sbjct: 1149 ELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQT--L 1206
Query: 1471 PSIEKTQKELVLSKPCKFEEKVSSEHFIQSHHGDLQALQQQLDTQKKAIRSIQEVQEELL 1530
S+ L E+K +S +I + +L + ++ QE LL
Sbjct: 1207 CSVLGEYYTPALKCEVNAEDKENSGDYISENE------DPELQDYRYEVQDFQENMHTLL 1260
Query: 1531 LQRLSELEKRVSSEQVCSSSFVSQVPVADSERTQKSFPTKSNDTLPSSHREIPRLQDRLL 1590
+ E K + + S + Q E +++ P + + L S H ++ L+D +
Sbjct: 1261 NKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFL-SIHSQMTNLEDIDV 1319
Query: 1591 SLSKPILPQQDNMTAQLDAQREVMYSYEKPQEELSLNKQRKLNKSESAEHTIPSLFLPKE 1650
+ + QD +L+ Q + + E L + Q++L KE
Sbjct: 1320 NHKSKLSSLQDLEKTKLEEQVQEL-------ESLISSLQQQL----------------KE 1356
Query: 1651 TEHSFIPLPFAEAKPKSTCELYSSQNEHAAPPSNPV 1686
TE ++ EA+ + + +E PPS PV
Sbjct: 1357 TEQNY------EAEIHCLQKRLQAVSESTVPPSLPV 1386
Score = 36.6 bits (83), Expect = 0.33
Identities = 129/619 (20%), Positives = 249/619 (40%), Gaps = 128/619 (20%)
Query: 303 ELEFAFEDMYNADRKVKGNLILHLEPEPLPTVTNQIQDEELDLSMEQENLGAAEDLPVTE 362
E + A E + ADR+ +L+ ++ + Q+ ++ L EQE+ +++L E
Sbjct: 3074 EYQAAMECLQKADRR---SLLSEIQ-----ALHAQMNGRKITLKREQESEKPSQEL--LE 3123
Query: 363 AEICSSETDVPLVMKTQQIPSKVLFKKLLNKIRSQKSLWT-IKS-MSEDESEMITTVSEI 420
I ++ + L M+ + K +L ++ S+K + +KS +++ + E+ TT+
Sbjct: 3124 YNIQQKQSQM-LEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQ 3182
Query: 421 ESKAPTVESGTIASKERTLSSGQEQVVESDTLTIESGPLASEDKPLSCGTNSGKEQEINE 480
+E+ + K++T D + + + LASE K K +E+
Sbjct: 3183 HKHLKELEAFRLEVKDKT-----------DEVHLLNDTLASEQK---------KSRELQW 3222
Query: 481 TLPITTVAQSSVLLHPQEAAARIRMSARQKQIME-----IEEQKQKQLE---LLEQIE-- 530
L +E A R R K+ +E +E QKQ+ L+ LLEQ +
Sbjct: 3223 ALE-------------KEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQL 3269
Query: 531 ----QQKLRLETDCFRAQLEEEKRKK------TQPTGVGIAPASCPVISDEDSHRQ---- 576
QQK+ + + AQL EE+ + + V I S + + + H Q
Sbjct: 3270 LNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSS 3329
Query: 577 --------------MIRNYQHQLLQQ-NRLHRQSVETARKQLLEYQT---MLKGRCPSVS 618
+++ Q QL ++ +R+ ET + +L QT M K R V
Sbjct: 3330 DGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDR--QVH 3387
Query: 619 APSLITDSVISVPSWK---------SERPTAISEHWDQGQRLKLSPNKYQPI-QPIQTSK 668
+L T+ + K + + E Q +L L + Q I Q Q +
Sbjct: 3388 RKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQE 3447
Query: 669 LEQDHFQVARQNHFPQRQVETTETLRASDILTNQALESQEHLRQFSQTETQQRDY-KLVP 727
LE++ + +R+ + TT +L SD N L+ Q + ET++ +Y KL+
Sbjct: 3448 LEREEKRESRRILYQNLNEPTTWSL-TSDRTRNWVLQ------QKIEGETKESNYAKLIE 3500
Query: 728 KDSETLSRALSHDRQLISQDARKISETFGATTFQSLESQQLFSENSENISYHLTEPSSFV 787
+ +H+ ++I Q + ++ + Q L + SE + + + F+
Sbjct: 3501 MNGG--GTGCNHELEMIRQKLQCVAS----------KLQVLPQKASERLQFETADDEDFI 3548
Query: 788 PLVPQHSFSSLPVKVESGKIQEPFSAMSKSTVSTSHSIISQMHDRPLLPSENITAQQGNM 847
+ L ++ +G+ E S +S ST S + +R L + +T +
Sbjct: 3549 WVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGS------LTERLLRQNAELTGHISQL 3602
Query: 848 KALQEQLDLQKKVLQATQE 866
+E+ DL+ V++ ++
Sbjct: 3603 --TEEKNDLRNMVMKLEEQ 3619
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 79.3 bits (194), Expect = 4e-14
Identities = 390/1989 (19%), Positives = 759/1989 (38%), Gaps = 349/1989 (17%)
Query: 1 MKRKVVNTHKLRLSPNEEAFILKEDYERRRKLRLLQVREQERDIALQIRE---------- 50
+K K+ KL L +E + K + KL L +++ER + +I++
Sbjct: 348 LKDKLTTADKL-LGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQK 406
Query: 51 ----------DIKQRRNQQFTRLAEELRAEWEESQTQKI----QNLEKLYLASLRSMGEG 96
DI QR Q+ R E+LRAE +E Q+I Q L + ++A + M
Sbjct: 407 RNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTR 466
Query: 97 HRQAKENEPDLDALAQRAAERKRKADLRHKEALKVQKNQKEILLKQKTWHIKARKEAL-L 155
H+ EN AL + + ++ + V N+ I L+ + KE L L
Sbjct: 467 HKGEMEN-----ALRSYSNITVNEDQIK---LMNVAINELNIKLQDTNSQKEKLKEELGL 518
Query: 156 VEKERSAKITSLPPPPPTLFENIEVKRISAVKTNSSTYHHLHTFVNRETDTKRPDARLAA 215
+ +E+ A L L E + R + T +E+ L+
Sbjct: 519 ILEEKCALQRQL----EDLVEELSFSREQIQRAR-------QTIAEQESKLNEAHKSLST 567
Query: 216 EEEAKRLEELQKQAAQERMERFEKAHVRGFQAMKKIHLAQNQEKLMKELKQLQQEDLARR 275
E+ K E + +++ +E +A V ++ +K L + + ++ + + Q+ +L R
Sbjct: 568 VEDLK-AEIVSASESRKELELKHEAEVTNYK-IKLEMLEKEKNAVLDRMAESQEAELERL 625
Query: 276 RQTVAQMPPQLVELPYKRSEMKEDWQRELEFAFEDMYNADRKVKGNLILHLEPEPLPTVT 335
R + L + S++KED + E E K+K NL +H + + + +
Sbjct: 626 RTQL------LFSHEEELSKLKEDLEIEHRINIE-------KLKDNLGIHYK-QQIDGLQ 671
Query: 336 NQIQDEELDLSMEQENLGAAEDLPVTEAEICSSETDVPLVMKTQQIPSKVLFKKLLNKIR 395
N++ + + E++NL ++ + E + K++++ ++ N++
Sbjct: 672 NEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQI------NEL- 724
Query: 396 SQKSLWTIKSMSEDESEMITTVSEIESKAPTVESGTIASKERTLSSGQEQVVESDTLTIE 455
QK + ++ +++ + V E++ K +E + KE L QE+ + L E
Sbjct: 725 -QKEIEILRQEEKEKGTLEQEVQELQLKTELLEK-QMKEKENDL---QEKFAQ---LEAE 776
Query: 456 SGPLASEDKPLSCGTNSGKEQEINETLPI-TTVAQSSVLLHPQEAAARIRMSARQKQ--- 511
+ L E K L + L I T V+Q L+ ++ + S +K+
Sbjct: 777 NSILKDEKKTL------------EDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEI 824
Query: 512 -IMEIEEQKQKQLELLEQIEQQKLRLETDCFRAQLEEEKRKKTQPTGVGIAPASCPVISD 570
I E E+ KQ+ ++L E+IE+Q+ T F + +
Sbjct: 825 LIEENEDLKQQCIQLNEEIEKQR---NTFSFAEK------------------------NF 857
Query: 571 EDSHRQMIRNYQHQLLQQNRLHRQSVETARKQLLEYQTMLKGRCPSVSAPSLITDSVISV 630
E +++++ Y L ++ L ++ KQ LEY++ LK + + +V
Sbjct: 858 EVNYQELQEEYACLLKVKDDLE----DSKNKQELEYKSKLKALNEELHLQRINPTTVKMK 913
Query: 631 PSWKSERPTAISEHWDQGQRL---------KLSPNKYQPIQPIQ-----TSKLEQDHFQV 676
S E T ++E + G+ + KL K + ++ Q + +L+Q H ++
Sbjct: 914 SSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEI 973
Query: 677 ARQNH----FPQRQVETTETLRASDILTNQALESQEHLRQFSQTETQQRDYKLVPKDSET 732
+ N Q + + + R +I+ N ++ Q T+ +V S
Sbjct: 974 SFLNEEVKSLKQEKEQVSLRCRELEIIIN---HNRAENVQSCDTQVSSLLDGVVTMTSRG 1030
Query: 733 LSRALSHDRQLISQDARKISET----FGATTFQSLESQQLFSENSENI----SYHLTEPS 784
++S + ++++ + E T + + +QL ++ ++ S T+PS
Sbjct: 1031 AEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPS 1090
Query: 785 SFVPLVPQHSFSSLPVKVESGKIQEPFSAMSKSTVSTSH-----SIISQMHDRPL--LPS 837
L Q + L + ++Q + S V ++H + D+ L L
Sbjct: 1091 ENDKL--QKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKE 1148
Query: 838 ENITAQQGNMKALQE--QLDLQKKVLQATQEAQEQLLLC---KQKEVEQQTGLSVFL-PL 891
E I AQ+ +K LQ+ QL+LQ Q T + + L L QK V ++ S FL L
Sbjct: 1149 ELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEE--CSYFLQTL 1206
Query: 892 VTPDSSALLPSAKADLGRIQESSPTKNNIAVSSDHHVISQLQDKRLSLSQPILSQQNNFK 951
+ P+ K ++ ++ K N + +LQD R + Q N
Sbjct: 1207 CSVLGEYYTPALKCEV-----NAEDKENSGDYISENEDPELQDYRYE----VQDFQENMH 1257
Query: 952 FLQEQLNIQKDSLQARREAQEVLYVHKQSELDRRVCSEQAEPSFPFQVAQHTFTSLPSAD 1011
L ++ + + L + ++ + + E E + P + + F S+ S
Sbjct: 1258 TLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMK----LEFGEENLPKEETE--FLSIHSQM 1311
Query: 1012 TKSGKIQEQHSSKSEKGLVSCQSDIPISQDGSLSFLQQFLPLHDSLKLLQEQLTKQRDTL 1071
T I H SK +S D+ +Q L + LQ+QL +
Sbjct: 1312 TNLEDIDVNHKSK-----LSSLQDLE-----KTKLEEQVQELESLISSLQQQLKE----T 1357
Query: 1072 QARHEAQVELLLHRQRDLGDSKSGLVSSSSSPVVVQHSVASQASAKAEPRRIQELYLSEK 1131
+ +EA++ L R L + S S V V S +++ +R K
Sbjct: 1358 EQNYEAEIHCLQKR----------LQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVK 1407
Query: 1132 ENVGPSCHLIIPTFQDKSLSFP-QHSLAQQENLTIL---QEQSQIQRVILGAKEGTQEFV 1187
+N+ D ++ F + + ++ N+ L Q Q Q++ +
Sbjct: 1408 KNI------------DGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAF 1455
Query: 1188 HTESELEKRISSEQTGTSSSLS----------QVDESERFQECISIKSDSTIPLSHPKIP 1237
++EL RIS + T+SS +E + Q+ I ++ T+
Sbjct: 1456 AQQTEL-SRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVD------- 1507
Query: 1238 RCQERLLRVSQHMLPLQDNLEEHQAWLDTEKEAFHFSQKTQE--NTSSEQTGSSS---FI 1292
++ + PL L EH + H ++++ T SE+ S +
Sbjct: 1508 ------VKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIV 1561
Query: 1293 PQLV--QLSFTSLASAESGTILEPLFTESESKIFSSHLQIPQLQDRLLRISQLIQPQ--- 1347
Q + ++S +S+ ++ + E + ++ + Q Q LLR + + Q +
Sbjct: 1562 RQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQY-QEHQQATELLRQAHMRQMERQR 1620
Query: 1348 ------QDNLKALQEQLA-----------TQREAIILARQEAREELLLHQSE---WEGRI 1387
Q+ +K L QLA ++RE ++L EA ++L L E E R
Sbjct: 1621 EDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRN 1680
Query: 1388 SPEQVDTSSLPLVPQHSFASLPLNESERNQEPCSINSDNIVSSGHSEIPTLPDGLLGLSH 1447
S Q + Q E E +++P + + I+S+ + + LL
Sbjct: 1681 SSTQTQNGN---ENQGEVEEQTFKEKELDRKPEDVPPE-ILSNERYALQKANNRLL---K 1733
Query: 1448 LVLPQQDNLIALEEHLHAQT-DFLPSIEKTQKELVL---------SKPCKFEEKVS-SEH 1496
++L A+EE + L K+Q L K C EE ++
Sbjct: 1734 ILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDE 1793
Query: 1497 FIQSHHGD----------LQALQQQLDTQKKAIRS------IQEVQEELLLQRLSELEKR 1540
I S+ G + ++ + ++ +RS I EEL+L S L+
Sbjct: 1794 SIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAA 1853
Query: 1541 VSS--EQVC-SSSFVSQVPVADSERTQKSFPTKSNDTLPSSHREIPRLQDRLLSLSKPIL 1597
V E + +SS + V +E ++SF K T +E L++RL S+
Sbjct: 1854 VEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQE--ELRERLHEESR--- 1908
Query: 1598 PQQDNMTAQLDAQREVMYSYEKPQEELSLNKQRKLNKSESAEHTIPSLFLPKETEHSFIP 1657
++ + +L V+ Y +E +L +++ K++ + L +
Sbjct: 1909 -AREQLAVELSKAEGVIDGY---ADEKTLFERQIQEKTDIIDRLEQELLC---ASNRLQE 1961
Query: 1658 LPFAEAKPKSTCELYSSQNEHAAPPSNPV---IPGFQDRLLSFSQSVLTQQDNL--GLQK 1712
L + + + EL S Q E + PV + ++L+ V Q + + LQK
Sbjct: 1962 LEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQK 2021
Query: 1713 Q-----LDLQREVLHYSQKAQEKL-----LVQRQTALQQQIQKHEETLKDFFKDSQISKP 1762
Q +D++ +V + + QEK L Q+ AL++Q++K + L + D + +
Sbjct: 2022 QVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERD 2081
Query: 1763 TVENDLKTQKMGQLRDWFPNTQDLAGNDQENIRHADRNNSDDNHLASEDTSAKQSGEHLE 1822
+ ++ QK+ Q P Q ++ + + + + SE +K E L+
Sbjct: 2082 VFQQEI--QKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSK---EQLQ 2136
Query: 1823 KDLGRRSSK 1831
+D+ R+ +
Sbjct: 2137 RDIQERNEE 2145
Score = 76.6 bits (187), Expect = 3e-13
Identities = 352/1891 (18%), Positives = 707/1891 (37%), Gaps = 298/1891 (15%)
Query: 27 ERRRKLRLLQVREQERDIALQIREDIKQRRNQQFTRLAEELRAEWEESQTQKIQNLEKLY 86
+ ++++ Q + +E+D L+ + K+ Q + L E+++ +E Q +K++N K
Sbjct: 265 QAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKV-YEMEQDKKVENSNK-- 321
Query: 87 LASLRSMGEGHRQAKENEPDLDALAQRAAERKRKADLRHKEALKVQKN-----QKEILLK 141
+ +E E ++ L + E ++K L K+ L Q++I+
Sbjct: 322 -----------EEIQEKETIIEELNTKIIEEEKKT-LELKDKLTTADKLLGELQEQIV-- 367
Query: 142 QKTWHIKARKEALLVEKERSAKITSLPPPPPTLFENIEVKRISAVKTNSSTYHHLHT--- 198
QK IK K L K++ + + E+K++ +H +
Sbjct: 368 QKNQEIKNMKLELTNSKQKERQSSE------------EIKQLMGTVEELQKRNHKDSQFE 415
Query: 199 --FVNR-ETDTKRPDARLAAEEEAKRLEELQKQAAQERMERFEKAHVRGFQAMKKIHLAQ 255
V R E +T+R +L AE L+E+ Q + + + H+ + MK H +
Sbjct: 416 TDIVQRMEQETQRKLEQLRAE-----LDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGE 470
Query: 256 NQEKLMKELKQLQQEDLARRRQTVAQMPPQLVELPYKRSE---MKEDWQRELEFAFEDMY 312
+ L ED + M + EL K + KE + EL E+
Sbjct: 471 MENALRSYSNITVNED------QIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKC 524
Query: 313 NADRKVKGNLI--LHLEPEPLPTVTNQIQDEELDLSMEQENLGAAEDLPVTEAEICS-SE 369
R+++ +L+ L E + I ++E L+ ++L EDL +AEI S SE
Sbjct: 525 ALQRQLE-DLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDL---KAEIVSASE 580
Query: 370 TDVPLVMKTQQIPSKVLFKKLLNKIRSQKSLWTIKSMSEDESEMITTVSEIESKAPTVES 429
+ L +K + + +K L + +K+ + M+E + E++ + +
Sbjct: 581 SRKELELKHEAEVTN--YKIKLEMLEKEKNA-VLDRMAESQ----------EAELERLRT 627
Query: 430 GTIASKERTLSSGQEQVVESDTLTIES--GPLASEDKPLSCGTNSGKEQEINE------- 480
+ S E LS +E + + IE L K G + Q+I
Sbjct: 628 QLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDN 687
Query: 481 --TLPITTVAQSSVLLHPQEAAARIRMSARQKQIMEIEEQKQKQLELLEQIEQQKLRLET 538
T + + S L Q++ + QI E+ QK++E+L Q E++K LE
Sbjct: 688 LITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINEL----QKEIEILRQEEKEKGTLEQ 743
Query: 539 DCFRAQLEEEKRKKTQPTGVGIAPASCPVISDEDSHRQMIRNYQHQLLQQNRLHRQSVET 598
+ QL+ E +K + E+S ++++ + L ++H +
Sbjct: 744 EVQELQLKTELLEKQMKEKENDLQEKFAQLEAENS---ILKDEKKTLEDMLKIHTPVSQE 800
Query: 599 ARKQLLEYQTMLKGRCPSVSAPSLITDSVISVPSWKSERPTAISEHWDQGQRLKLSPNKY 658
R L+ S S DSV W+ E I E+ D K
Sbjct: 801 ERLIFLD------------SIKSKSKDSV-----WEKEIEILIEENEDL---------KQ 834
Query: 659 QPIQPIQTSKLEQDHFQVARQN---HFPQRQVETTETLRASDILTN-------------Q 702
Q IQ + + +++ F A +N ++ + Q E L+ D L + +
Sbjct: 835 QCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLK 894
Query: 703 ALESQEHLRQFSQTETQQRDYKLVPKDSETLSRALSHDRQLISQDARKISETFGATTFQS 762
AL + HL++ + T + + + +D ++ L +++ +D ++ E T +
Sbjct: 895 ALNEELHLQRINPTTVKMKS-SVFDEDKTFVAETLEMG-EVVEKDTTELMEKLEVTKREK 952
Query: 763 LESQQLFSENSENISYHLTEPSSFVPLVPQHSFSSLPVKVESGKIQEPFSAMSKSTVSTS 822
LE Q S+ SE + E S V V + +++ + V +
Sbjct: 953 LELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSC 1012
Query: 823 HSIISQMHDRPLLPSENITAQQGNMKALQEQLDLQKKVLQATQEAQEQLLLCKQKEVEQQ 882
+ +S + D + + +G++ + + + K++ + + E + + ++ + EQ
Sbjct: 1013 DTQVSSLLDGVVTMTSR--GAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQL 1070
Query: 883 TGLSVFLPLVTPDSSALLPSAKADLGRIQESSPTKNNIAVSSDHHVISQLQDKRLSLSQP 942
+ LP VT +SS ++ + P++N DK
Sbjct: 1071 --ILDHLPSVTKESS------------LRATQPSEN---------------DKLQKELNV 1101
Query: 943 ILSQQNNFKFLQEQLNIQKDSLQARREAQEVLYVHKQSELDRRVCSEQAEPSFPFQVAQH 1002
+ S+QN+ + E I + + Q Y+ ++E D+ +CS + E F +
Sbjct: 1102 LKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYM--ENEKDKALCSLKEELIFAQEEKIK 1159
Query: 1003 TFTSLPSADTKSGKIQEQHSSKSEKGLVSCQSDIPISQDGS------LSFLQQFLPLHDS 1056
+ + ++ K QE L+ + +S++ S S L ++
Sbjct: 1160 ELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALK 1219
Query: 1057 LKLLQEQLTKQRDTLQARHEAQVELLLHRQRDLGDSKSGLVSSSSSP----VVVQHSVAS 1112
++ E D + + +++ + +D ++ L++ + +V+Q ++
Sbjct: 1220 CEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSK 1279
Query: 1113 QASAKAEPRRIQ--ELYLSEKENVGPSCHLIIPTFQDKSLSFPQH-SLAQQENLTILQEQ 1169
+ + +++ E L ++E S H + +D ++ S Q T L+EQ
Sbjct: 1280 IWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQ 1339
Query: 1170 SQIQRVILGA-----KEGTQEFVHTESELEKRISSEQTGTSSSLSQVD-----ESERFQ- 1218
Q ++ + KE Q + L+KR+ + T VD ES+ +
Sbjct: 1340 VQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRT 1399
Query: 1219 ----ECISIKSDSTIPLSHPKIPRCQERLLRVSQHMLPLQDNLEEHQAWLDTEKEAFHFS 1274
C+ D TI S + + ++++ + Q+ LEE A + + F+
Sbjct: 1400 MYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQ--YQEQLEEEVAKVIVSM-SIAFA 1456
Query: 1275 QKTQ--------ENTSSEQTGSSSFIPQLVQLSFTSLASAESGTILEPLFT-----ESES 1321
Q+T+ ENT+S + + + Q Q F + ++ + T + E
Sbjct: 1457 QQTELSRISGGKENTASSKQAHA--VCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEF 1514
Query: 1322 KIFSSHL---------------QIPQLQDRLLRISQLIQPQQDNLKALQEQLATQREAII 1366
K S L IP+ +D +L IS+ + + Q + + I
Sbjct: 1515 KPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQ----SIHDEIS 1570
Query: 1367 LARQEAREELLLHQSEWEGR----ISPEQVDTSSLPLVPQHSFASLPLNESERNQ----- 1417
++ +A +L+L++ + E + Q + L+ Q + ++ Q
Sbjct: 1571 VSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEI 1630
Query: 1418 --------EPCSINSDNIVSSGHSEIPTLPDGLLGLSHLVLPQQDNLIALEEHLHAQT-- 1467
+ SI+++N+VS L + L L L L ++ L + QT
Sbjct: 1631 KRLNRQLAQRSSIDNENLVSERER---VLLEELEALKQLSLAGREKLCCELRNSSTQTQN 1687
Query: 1468 ---DFLPSIEKTQKELVLSKPCKFEEKVSSEHFIQSHHGDLQALQQQLDTQKKAIRSIQE 1524
+ E+T KE L + E V E + +A + L + +++
Sbjct: 1688 GNENQGEVEEQTFKEKELDRK---PEDVPPEILSNERYALQKANNRLLKILLEVVKTTAA 1744
Query: 1525 VQEELLLQRLSELEKRVSSEQVCSSSFVSQVPVADSERTQKSFPTKSNDTLPS-SHREIP 1583
V+E + L L++ S+ S + S+ + + +++++PS S ++P
Sbjct: 1745 VEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMP 1804
Query: 1584 RLQDRLLSLSKPILPQQDNMTAQLDAQREVMYSYEKPQEELSLNKQRKLNKS-----ESA 1638
R +++ + + ++ +L + EEL LN +L + E+
Sbjct: 1805 RND---INMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAI 1861
Query: 1639 EHTIPSLFLPKETEHSFIPLPF---AEAKPKSTCELYSSQNEH-----------AAPPSN 1684
T L K T+ + F EA C+ + H +
Sbjct: 1862 SETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAE 1921
Query: 1685 PVIPGFQDRLLSFSQSVLTQQDNLGLQKQLDLQREVLHYSQKAQEKLLVQRQTALQQQIQ 1744
VI G+ D F + + + D + L++E+L S + QE A QQQIQ
Sbjct: 1922 GVIDGYADEKTLFERQIQEKTDIID-----RLEQELLCASNRLQE------LEAEQQQIQ 1970
Query: 1745 KHEETLKDFFKDSQISKPTVENDL--KTQKM 1773
+ E L + + VE L +T+K+
Sbjct: 1971 EERELLSRQKEAMKAEAGPVEQQLLQETEKL 2001
Score = 66.2 bits (160), Expect = 4e-10
Identities = 206/1053 (19%), Positives = 420/1053 (39%), Gaps = 159/1053 (15%)
Query: 339 QDEELDLSMEQENLGAAEDLPVTEAEICSSETDVPLVMKTQQIPSKVLFKKLLNKIRSQK 398
++EEL L++ A E L +E SS+ + V +T+ + F++ S K
Sbjct: 1838 ENEELMLNISSRLQAAVEKLLEAISET-SSQLEHAKVTQTELMRES--FRQKQEATESLK 1894
Query: 399 SLWTIKSMSEDESEMITTVSEIESKAPTVESGTIASKERTLSSGQEQVVESDTLTIESGP 458
++ +ES ++ SKA V G + E+TL E+ ++ T I+
Sbjct: 1895 CQEELRERLHEESRAREQLAVELSKAEGVIDGY--ADEKTLF---ERQIQEKTDIIDR-- 1947
Query: 459 LASEDKPLSCGTNSGKEQEINETLPITTVAQSSVLLHPQEAAARIRMSARQKQIMEIEEQ 518
++ L C +N +E E + Q+ + +RQK+ M+ E
Sbjct: 1948 ---LEQELLCASNRLQELEAEQ----------------QQIQEERELLSRQKEAMKAEAG 1988
Query: 519 KQKQLELLEQIEQQKLRLETDCFRAQLEEEKRKKTQPTGVGIAPASCPVISDEDSHRQMI 578
+Q L E + K +LE C ++ ++ +K+ + + + I E +
Sbjct: 1989 PVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTEL 2048
Query: 579 RNYQHQLLQQNRLHRQSVETARKQLLEYQTMLKGRCPSVSAPSLITDSVISVPSWKSERP 638
+ L QQN+ + +E RK L+ Q + + + ER
Sbjct: 2049 MD----LRQQNQALEKQLEKMRK-FLDEQAIDR----------------------EHERD 2081
Query: 639 TAISEHWDQGQRLKLSPNKYQPIQPIQTSKLEQDHFQVARQNHFPQRQVETTETLRASDI 698
E Q+LK+ P ++QPI QT ++EQ NH ++ + +E L + +
Sbjct: 2082 VFQQEIQKLEQQLKVVP-RFQPISEHQTREVEQ------LANHLKEKTDKCSELLLSKEQ 2134
Query: 699 LTNQALESQEHLR--QFSQTETQQ----RDYK----LVPKDSETLSRALSHDRQLISQDA 748
L E E + +F E +Q D K + K +L L +R I +
Sbjct: 2135 LQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKE 2194
Query: 749 RKISETFGATTFQSLESQ-QLFSENSENISYHLTEPSSFVPLVPQHSFSSLPVKVESGKI 807
++I+ +LE Q + F E EN + + + + + + S + L + K+
Sbjct: 2195 KEIT---------NLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKL 2245
Query: 808 QEPFSAMSKSTVSTSHSIISQMHDR--------PLLPSENITAQQGN--MKALQEQLDL- 856
+ M K ++ S D+ ++ + + Q N + LQ+QL +
Sbjct: 2246 FK--DDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKIT 2303
Query: 857 -------QKKVLQATQEAQEQLLLCKQKEVEQQTGLSVFLPLVTPDSSALLPSAKADLGR 909
+K L E Q + L+ Q+ V++ + + ++ + +L
Sbjct: 2304 TDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEI------EQLNEVIEKLQQELAN 2357
Query: 910 I-QESSPTKNNIAVSSD--HHVISQLQDKRLSLSQPILSQQNNFKFLQEQLNIQKDSLQA 966
I Q++S ++++ +D H + + ++L+L Q + + F++ L ++ + +
Sbjct: 2358 IGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVL--KETNFKM 2415
Query: 967 RREAQEVLYVHKQSELDRRVCSEQAEPSFPFQVA-QHTFTSLPSADTKSGKIQEQHSSKS 1025
+ QE+ + ++ E ++ Q+ P VA H P + + + + KS
Sbjct: 2416 NQLTQELFSLKRERESVEKI---QSIPENSVNVAIDHLSKDKPELEV----VLTEDALKS 2468
Query: 1026 EKGLVSCQSDIPISQDGSLSFLQQFLPLHDSLKLLQEQLT---KQRDTLQARHEAQVELL 1082
+ +S + ++ + L L ++ +LT KQ +Q + + + E+L
Sbjct: 2469 LENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEML 2528
Query: 1083 ----LHRQRDLGDS-KSGLVSSSSSPVVVQHSVASQ----ASAKAEPRRIQELYLSEKEN 1133
++ Q+ + + + LVS V +++ Q S++ E IQ L ++
Sbjct: 2529 QKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDE 2588
Query: 1134 VG---PSCHLIIPTFQDKSLSFPQHSLAQQENLTILQEQ-SQIQRVILGAKEGTQEFVHT 1189
+G + L I + + + + ++E + I ++ + ++ +L ++ +
Sbjct: 2589 LGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKK 2648
Query: 1190 ESELEKRISSEQTGTSSSLSQV----DESERFQECISIKSDSTIPLSH-----PKIPRCQ 1240
+ E EK+ S + + +++ +ES F E +++++S + K + Q
Sbjct: 2649 QREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQ 2708
Query: 1241 ERLLRVSQHMLPLQDNLEEHQAWLDTEKEAFHFSQKTQENTSSEQTGSSSFIPQLVQLSF 1300
E LL +M LQ +L + + L KE +K E E + F P ++LS
Sbjct: 2709 EELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLS- 2767
Query: 1301 TSLASAESGTILEPLFTESESKIFSSHLQIPQL 1333
S+AS GT+ KI SS+ Q PQ+
Sbjct: 2768 KSIASQTDGTL----------KISSSN-QTPQI 2789
Score = 65.1 bits (157), Expect = 9e-10
Identities = 310/1697 (18%), Positives = 665/1697 (39%), Gaps = 260/1697 (15%)
Query: 181 KRISAVKTNSSTYHHL---HTFVNRETDTKRPDAR--LAAEEEAKRLEELQKQAAQERME 235
K + A+ SS H T + RE+ ++ +A L +EE + + +A ++
Sbjct: 1856 KLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAV 1915
Query: 236 RFEKAH--VRGFQAMKKIHLAQNQEKLMKELKQLQQEDL--ARRRQTVAQMPPQLVELPY 291
KA + G+ K + Q QEK + +L+QE L + R Q + Q+ E
Sbjct: 1916 ELSKAEGVIDGYADEKTLFERQIQEKT-DIIDRLEQELLCASNRLQELEAEQQQIQEERE 1974
Query: 292 KRSEMKEDWQRELEFAFEDMYNADRKV-KGNLILHLEPEPL-PTVTNQIQDEELD----- 344
S KE + E + + K+ K L + + E + + Q++ E+D
Sbjct: 1975 LLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQV 2034
Query: 345 ---LSMEQENLGAAEDLPVTEAEICSSETDVPLVMKTQQIP---SKVLFKKLLNKIRSQ- 397
+ +EQE DL + + + Q I + +F++ + K+ Q
Sbjct: 2035 SRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQL 2094
Query: 398 KSLWTIKSMSEDESEMITTVSEIESKAPTVESGTIASKERTLSSGQEQVVESDTLT---- 453
K + + +SE ++ + ++ + S + SKE+ QE+ E + L
Sbjct: 2095 KVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVR 2154
Query: 454 -IESGPLASEDKPLSCGTNSGKEQEINETLPITTVAQSSVLLHPQEAAARIRMSARQKQI 512
+E L + K A+ + L Q A R + ++K+I
Sbjct: 2155 ELEQALLVEDRKHFGA-----------------VEAKPELSLEVQLQAERDAIDRKEKEI 2197
Query: 513 MEIEEQKQKQLELLE----QIEQQKLRLE------TDCFRAQLEEEKRKKTQPTGVGIAP 562
+EEQ ++ E LE +++Q ++LE T + +E K K +G+A
Sbjct: 2198 TNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAI 2257
Query: 563 ASCPVISDEDSHRQMIRNYQHQLLQQNRLHRQSVETARKQLLEYQTMLKGRCPSVSAPSL 622
+S +D H ++ Q++Q+ + ++ +Q+ + Q LK +
Sbjct: 2258 KESDAMSTQDQH--VLFGKFAQIIQEKEVE---IDQLNEQVTKLQQQLK----------I 2302
Query: 623 ITDSVISVPSWKSERPTAISEHWDQGQRLKLSPNKYQPIQPIQT--SKLEQDHFQVARQN 680
TD+ + + R + + N+ + I+ + KL+Q+ + ++
Sbjct: 2303 TTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKT 2362
Query: 681 HFPQRQV-ETTETLR-------ASDILTNQALESQEHLRQFSQTETQQRDYKLVPKDSET 732
+ E ++L+ A + Q +E+ F + ++ ++K+ E
Sbjct: 2363 SMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQEL 2422
Query: 733 LSRALSHDRQLISQDARKISETFGATTFQSLESQQLFSENSENISY-HLTEPSSFVPLV- 790
S L +R+ S+E Q ENS N++ HL++ + +V
Sbjct: 2423 FS--LKRERE-------------------SVEKIQSIPENSVNVAIDHLSKDKPELEVVL 2461
Query: 791 PQHSFSSLPVKVESGKIQEPFSAMSKSTVSTSHSIISQMHDRPLLPSENITAQQGNMKAL 850
+ + SL E+ + F K ++ + + Q+ +T +K +
Sbjct: 2462 TEDALKSL----ENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDM 2517
Query: 851 QEQLD-----LQKKVLQATQEAQEQLL--LCKQKEVEQQTGLSVFLPLVTPDSSALLPSA 903
QEQ LQKK++ + +E++ L Q ++E + F D+ + S+
Sbjct: 2518 QEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQ----DNQTI--SS 2571
Query: 904 KADLGRIQESSPTKNNIAVSSDHHVISQLQDKRLSLSQPILSQQNNFKFLQEQLNI-QKD 962
+ + IQ + + + + SD IS L + L ++ + +EQ+ I +K+
Sbjct: 2572 EPERTNIQNLNQLRED-ELGSD---ISALTLRISELESQVVEMHTSLILEKEQVEIAEKN 2627
Query: 963 SLQARREAQEVLYVHKQSELDRRVCSEQAEPSFPFQVAQHTFTSLPSADTKSGKIQEQHS 1022
L+ ++ E+ + + +E +R ++ P +V + T T L ++ +SG E +
Sbjct: 2628 VLEKEKKLLELQKLLEGNEKKQREKEKKRSPQ-DVEVLKTT-TELFHSNEESGFFNELEA 2685
Query: 1023 SKSEKGLVSCQSDIPISQDGSLSFLQQFLPLHDSLKLLQEQLTKQRDTLQARHEAQVELL 1082
++E V+ ++++ ++ + ++ L ++ LQ+ L++ RD L E L
Sbjct: 2686 LRAES--VATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILE 2743
Query: 1083 LHRQRDLGDSKSGLVSSSSSPVVVQHSVASQASAKAEPRRIQELYLSEKENVGPSCHLII 1142
+ ++ +SK + P+ + S+ASQ + + +N G +L
Sbjct: 2744 KEDETEVQESKKACMFEPL-PIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINL-- 2800
Query: 1143 PTFQDKSLSFPQHSLAQQ--ENLTILQEQSQIQRVILGAKEGTQ-EFVHTESELEKRISS 1199
Q + S + Q E + +QE + + + ++ ++ E + E + ++
Sbjct: 2801 ---QSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLK 2857
Query: 1200 EQTGTSSSLSQVDESERFQECISIKSDSTIP-LSHPKIPRCQERLLRVSQHMLPLQDNLE 1258
E+ GT ++ Q C+ K S+IP L+H + +E + +
Sbjct: 2858 EECGTLKAVIQ---------CLRSKEGSSIPELAHSDAYQTRE--------ICSSDSGSD 2900
Query: 1259 EHQAWLDTEKEAFHFSQKTQENTSSEQTGSSSFIPQLVQ--LSFTSLASAESGTILEPLF 1316
Q T + F + + + S T S P+ ++ L + ++ E +
Sbjct: 2901 WGQGIYLTHSQGFDIASEGRGEESESATDS---FPKKIKGLLRAVHNEGMQVLSLTESPY 2957
Query: 1317 TESESKIFSSHLQIPQLQDRLLRISQLIQPQQDNLKALQEQLATQREAIILARQEAREEL 1376
++ E + P L++R I+ + +LK L ++ QREA + ++ E
Sbjct: 2958 SDGEDHSIQQ-VSEPWLEERKAYINTI-----SSLKDLITKMQLQREAEVYDSSQSHESF 3011
Query: 1377 LLHQSEWEGRISPEQVDTSSLPLVPQHSFASLPLNESERNQEPCSINSDNIVSSGHSEIP 1436
S+W G L L Q F ER+ ++++ +E+
Sbjct: 3012 ----SDWRGE----------LLLALQQVFLE------ERSV---------LLAAFRTELT 3042
Query: 1437 TL-PDGLLGLSHLVLPQQDNLIALEEHLHAQ----TDFLPSIEKTQKELVLSKPCKFEEK 1491
L +GL L LE+ + Q + ++K + +LS+ +
Sbjct: 3043 ALGTTDAVGL----------LNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQ 3092
Query: 1492 VSSEHFIQSHHGDLQALQQQL---DTQKKAIRSIQ-EVQEELLLQRLSELEKRVSSEQVC 1547
++ + + Q+L + Q+K + ++ +V+ + R +EL++++SSE++
Sbjct: 3093 MNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMV 3152
Query: 1548 SSSFVSQVPVADSERTQKSFPTKSNDTLPSSHREIPRLQDRLLSL---SKPILPQQDNMT 1604
+ S++ +T+ T TL + H+ + L+ L + + + D +
Sbjct: 3153 VAELKSEL-----AQTKLELET----TLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLA 3203
Query: 1605 AQLDAQREVMYSYEKPQEELSLNKQRKLNKSESAEHTIPS-----LFLPKETEHSFIPLP 1659
++ RE+ ++ EK + +L +++R + E + ++ S L L E L
Sbjct: 3204 SEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLN 3263
Query: 1660 FAEAKPKSTCELYSSQNEHAAPPSNPVIPGFQDRLLSFSQSVLTQQDNLGLQKQLDLQRE 1719
++ K +S LY +Q S + ++L S+ V ++ + L ++ +L +
Sbjct: 3264 ESQQKIESQRMLYDAQ------LSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQ 3317
Query: 1720 VLHYSQKAQ-------EKLLVQRQTALQQ----------QIQKHE----ETLKDFFKDSQ 1758
+ Q E LL + Q L++ + +K++ +T + KD Q
Sbjct: 3318 LQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQ 3377
Query: 1759 ISKPTVENDLKTQKMGQ 1775
+ + T++ + + GQ
Sbjct: 3378 VHRKTLQTEQEANTEGQ 3394
Score = 61.2 bits (147), Expect = 1e-08
Identities = 452/2509 (18%), Positives = 904/2509 (36%), Gaps = 450/2509 (17%)
Query: 31 KLRLLQVREQERDIALQIREDIKQRRNQQFTRLAEE---LRAEWEES------QTQKIQN 81
+++L+ V E +I LQ K++ ++ + EE L+ + E+ ++IQ
Sbjct: 487 QIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQR 546
Query: 82 LEKLYLASLRSMGEGHRQAKENEPDLDALAQRAAERKRKADLRHKEALKVQKNQKEILLK 141
+ + E H+ E DL A A+E +++ +L+H+ + K + E+L K
Sbjct: 547 ARQTIAEQESKLNEAHKSLSTVE-DLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEK 605
Query: 142 QKTWHIKARKEALLVEKER--SAKITSLPPPPPTLFENIEVKR---ISAVKTNSSTYH-- 194
+K + E+ E ER + + S L E++E++ I +K N ++
Sbjct: 606 EKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQ 665
Query: 195 ----------------------------HLHTFVNRETDTKRPDARLAAEEEAKRLEELQ 226
L +++ D ++ +EE ++ ELQ
Sbjct: 666 QIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQ 725
Query: 227 KQAAQERMERFEKA----HVRGFQAMKKIHLAQNQEK---LMKELKQLQQED--LARRRQ 277
K+ R E EK V+ Q ++ Q +EK L ++ QL+ E+ L ++
Sbjct: 726 KEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKK 785
Query: 278 TVAQM---------PPQLVELPYKRSEMKED-WQRELEFAFEDMYNADRKVKGNLILHLE 327
T+ M +L+ L +S+ K+ W++E+E E+ N D K
Sbjct: 786 TLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEE--NEDLK---------- 833
Query: 328 PEPLPTVTNQIQDEELDLSMEQENLGAA-EDLPVTEAEICSSETDVPLVMKTQQIPSKVL 386
+ + +I+ + S ++N ++L A + + D+ Q++ K
Sbjct: 834 -QQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSK 892
Query: 387 FKKLLNKIRSQK-SLWTIKSMSEDESEMITTVSEIESKAPTVESGTIASKERTLSSGQEQ 445
K L ++ Q+ + T+K S E T V+E VE T E+ + +E+
Sbjct: 893 LKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREK 952
Query: 446 VVESDTLT-------------------IESGPLASEDKPLSCGT-----NSGKEQEINET 481
+ S L+ ++S E L C N + + +
Sbjct: 953 LELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSC 1012
Query: 482 -LPITTVAQSSVLLHPQEAAARI----RMSARQKQIMEIEEQKQKQLELLEQIEQQKLRL 536
++++ V + + A + + + +IM ++ + + + E+ +Q++L L
Sbjct: 1013 DTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLIL 1072
Query: 537 ETDCFRAQLEEEKRKKTQPTGVGIAPASCPVISDEDSHRQMIRNYQHQLLQQNRLHRQSV 596
D + +E + TQP+ V+ E + ++ Q+ Q
Sbjct: 1073 --DHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRL------QMEAQRICLSLVY 1124
Query: 597 ETARKQLLEYQTMLKGRCPSVSAPSLITDSVISVPSWKSERPTAIS-----EHWDQGQRL 651
T Q+ EY K + LI + + + E D+G+ L
Sbjct: 1125 STHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPL 1184
Query: 652 KLSPNKYQPIQPIQTSKLEQDHFQVARQNHFPQRQVETTETLRASD---ILTNQALESQE 708
L K Q + S Q V + + P + E + + I N+ E Q+
Sbjct: 1185 HLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQD 1244
Query: 709 HLRQFSQTETQQRDYKLVPKDSETLSRALSHDRQLIS---QDARKISETFGA-------T 758
+ ++ + Q+ + L+ K +E ++ L +L Q + FG T
Sbjct: 1245 Y--RYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEET 1302
Query: 759 TFQSLESQQLFSENSENISYHLTEPSSFVPLVPQHSFSSLPVKVES--GKIQEPFSAMSK 816
F S+ SQ N E+I + S + + + ++ES +Q+ +
Sbjct: 1303 EFLSIHSQMT---NLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQ 1359
Query: 817 STVSTSHSI------ISQMHDRPLLPSENITAQQGNMKALQEQLDLQKKVLQATQE---- 866
+ + H + +S+ P LP +++ + + + KK + T E
Sbjct: 1360 NYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGE 1419
Query: 867 --AQEQLLLCKQKEVEQQTGLSVFLPLVTPDSSALLPSAKADLGRIQESSPTKNNIAVSS 924
+E+ + K E + Q L + V S + + +L RI S K N A S
Sbjct: 1420 FGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAF-AQQTELSRI---SGGKENTASSK 1475
Query: 925 DHHVISQLQDKRLSLSQPILSQQNNFKFLQEQLNIQKDSLQARREAQEVLYVHKQ-SELD 983
H + Q + N K Q+Q+ Q + +E + K+ E
Sbjct: 1476 QAHAVCQQEQHYF----------NEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHG 1525
Query: 984 RRVCSEQAEPSFPFQVAQHTFTSLPSADTKSGKIQEQHSSKSEKGLV--SCQSDIPISQD 1041
+ + ++P +P + I E+ SK + +V S +I +S
Sbjct: 1526 KEILLSNSDPH-----------DIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVS-- 1572
Query: 1042 GSLSFLQQFLPLHDSLKLLQEQLTKQ-------RDTLQARHEAQVELLLHRQRDLGDS-- 1092
S+ +Q + + L+ ++++L +Q + L+ H Q+E Q L +
Sbjct: 1573 -SMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIK 1631
Query: 1093 -------------KSGLVSSSSSPVVVQHSVASQASAKAEPRRIQELYLSE------KEN 1133
LVS ++ + Q S + EL S EN
Sbjct: 1632 RLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNEN 1691
Query: 1134 VGPSCHLIIPTFQDKSLSFPQHSLAQQ----ENLTILQEQSQIQRVILGAKEGTQEFVHT 1189
G + TF++K L + + E + + +++ +++L E V T
Sbjct: 1692 QG---EVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILL-------EVVKT 1741
Query: 1190 ESELEKRISSEQTGTSSSLSQVDESERFQECISIKSDSTIPLSHPKIPRC-QERLLRVSQ 1248
+ +E+ I G +D S + Q S+ S S + C E RV+
Sbjct: 1742 TAAVEETIGRHVLGI------LDRSSKSQSSASLIWRSEAEAS---VKSCVHEEHTRVTD 1792
Query: 1249 HMLPLQDNLEEHQAWLDTEKEAFHFSQKTQENTSSEQTGSSSFIPQLVQLSFTSLASAES 1308
+P + + ++ +S+ T+E T Q +LV+ F +
Sbjct: 1793 ESIPSYSGSDMPRNDINM------WSKVTEEGTELSQ--------RLVRSGF-------A 1831
Query: 1309 GTILEPLFTESESKIFSSHLQIPQLQDRLLRISQLIQPQQDNLKALQEQLATQREAIILA 1368
GT ++P E+E + + ++ ++LL Q ++ K Q +L RE+
Sbjct: 1832 GTEIDP---ENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTEL--MRESF-RQ 1885
Query: 1369 RQEAREELLLHQSEWEGRISPEQVDTSSLPLVPQHSFASLPLNESERNQEPCSINSDNIV 1428
+QEA E L Q E R+ E R Q ++ V
Sbjct: 1886 KQEATESLKC-QEELRERLHEES---------------------RAREQLAVELSKAEGV 1923
Query: 1429 SSGHSEIPTLPDGLLGLSHLVLPQQDNLIALEEHLHAQTDFLPSIEKTQKELVLSKPCKF 1488
G+++ TL E + +TD + +E
Sbjct: 1924 IDGYADEKTL--------------------FERQIQEKTDIIDRLE-------------- 1949
Query: 1489 EEKVSSEHFIQSHHGDLQALQQQ---LDTQKKAIRSIQEVQEELLLQRL----------- 1534
+E + + + +Q + Q +Q++ L QK+A+++ E+ LLQ
Sbjct: 1950 QELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQ 2009
Query: 1535 -------SELEKRVSSEQVCSSSFVSQ-VPVADSERTQKSFPTKSNDTLPSS-------- 1578
+L+K+V + ++ VS+ + + + T+ + N L
Sbjct: 2010 CQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFL 2069
Query: 1579 --------------HREIPRLQDRLLSLSK--PILPQQDNMTAQL--------DAQREVM 1614
+EI +L+ +L + + PI Q QL D E++
Sbjct: 2070 DEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELL 2129
Query: 1615 YSYEKPQEELSLNKQRKLNKSESAEHTIPSLFLPKETEHSFIPLPFAEAKPKSTCELYSS 1674
S E+ Q ++ + ++ K E + L ++ +H EAKP+ + E+
Sbjct: 2130 LSKEQLQRDIQ-ERNEEIEKLEFRVRELEQALLVEDRKH----FGAVEAKPELSLEVQLQ 2184
Query: 1675 QNEHAAPPSNPVIPGFQDRLLSFSQSVLTQQDNLGLQKQLDLQREVLHYSQKAQEKLLVQ 1734
A I +++L F + + + + + +QL +Q E+ + + L Q
Sbjct: 2185 AERDAIDRKEKEITNLEEQLEQFREELENKNEEV---QQLHMQLEIQKKESTTRLQELEQ 2241
Query: 1735 RQTALQQQIQKHEETLKD------------FFKDSQ-ISKPTVENDLKTQKMGQLRDWFP 1781
+ ++K +K+ F K +Q I + VE D +++ +L+
Sbjct: 2242 ENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLK 2301
Query: 1782 NTQDLAGNDQENIRHADRNNSDDNHLASEDTSAKQSGEHLEK-DLGRRSSKPPVAKVKCG 1840
T D +++N D + ++ ++ + E +E+ + + +A +
Sbjct: 2302 ITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQK 2361
Query: 1841 LDLNQHELSAIQEVESPAIGRTSILGKPGIYEDRDPLRVSISREQSFFGSPLAHDPFSCL 1900
+N H LS +E +S ++ + E + + + E +F + L F
Sbjct: 2362 TSMNAHSLS--EEADSLKHQLDVVIAEKLALEQQVE---TANEEMTFMKNVLKETNFKMN 2416
Query: 1901 QLVGQENVCGDDYDEAVKLKESVVENHAVLSYAVEEEHAYLGPTVKPDDKAKTLSYEPL- 1959
QL QE E+V+ +S+ EN ++ + V +D K+L +
Sbjct: 2417 QLT-QELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYF 2475
Query: 1960 -SSATVSTGSLLSYENTDLSLTDPESFSE-HMDDSKQESTTSKEE---ETNIISSIVPST 2014
S GS+++ E L L S + + ++ +E+ ET ++ + +
Sbjct: 2476 KSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNL 2535
Query: 2015 QDIYQRQNSSD-VHKSLLPAVDETTCGHTHFQQMIDKYINEANLIPEKTDLQELEHI--- 2070
Q I + + ++ V + L AV E + F Q +E PE+T++Q L +
Sbjct: 2536 QKIVEEKVAAALVSQIQLEAVQE----YAKFCQDNQTISSE----PERTNIQNLNQLRED 2587
Query: 2071 ------------FPNLHHQLFKPLEPHPDFDLSSSSSGISPDN--------RDFYQRSDS 2110
L Q+ +E H L I+ N + + +
Sbjct: 2588 ELGSDISALTLRISELESQV---VEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEG 2644
Query: 2111 SSESHCATGLSKSTVYFTALRRTSMHSSLNTSPNQQPDTNLAHVGAHSFATENIIGGSEQ 2170
+ + +S L+ T+ +++ L + A S AT+ + ++
Sbjct: 2645 NEKKQREKEKKRSPQDVEVLKTTT--ELFHSNEESGFFNELEALRAESVATKAELASYKE 2702
Query: 2171 CFEQLQPEYSSQEESQHADLPSIFSIEARDSSQGMKNQNYPSEEHTEILQNKKKIVHFQL 2230
E+LQ E +E + + + + + K E+ TE+ ++KK + L
Sbjct: 2703 KAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPL 2762
Query: 2231 SIGNLSSVYSSSD------EANVFDQLNVQHSTPCGSNSSECSTKHQLE 2273
I S+ S +D +N Q+ V+++ + SECS++ E
Sbjct: 2763 PIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTE 2811
Score = 60.5 bits (145), Expect = 2e-08
Identities = 216/1107 (19%), Positives = 429/1107 (38%), Gaps = 208/1107 (18%)
Query: 38 REQERDIALQIREDIKQRRNQQFTRLAEELRAEWEESQ--------------------TQ 77
++QE +L+ +E++++R +++ +R E+L E +++ T
Sbjct: 1885 QKQEATESLKCQEELRERLHEE-SRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTD 1943
Query: 78 KIQNLEKLYLASLRSMGEGHRQAKENEPDLDALAQRAAERKRKADLRHKEALKVQKNQKE 137
I LE+ L + + E L+A Q+ E +R+ R KEA+K + E
Sbjct: 1944 IIDRLEQELLCASNRLQE-----------LEAEQQQIQE-ERELLSRQKEAMKAEAGPVE 1991
Query: 138 ILLKQKTWHIKARKEALLVEKERSAKITSLPPPPPTLFENIEVKRISAVKTNSSTYHHLH 197
L Q+T K KE L V+ + L K++ A++ +
Sbjct: 1992 QQLLQET--EKLMKEKLEVQCQAEKVRDDLQ------------KQVKALEIDVEEQVSRF 2037
Query: 198 TFVNRETDTKRPDARLAAEEEAKRLEELQKQAAQERMERFEKAHVRGFQAMKKIHLAQNQ 257
+ +E +T+ D R + K+LE+++K ++ ++R + V FQ Q
Sbjct: 2038 IELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDV--FQ--------QEI 2087
Query: 258 EKLMKELKQLQQEDLARRRQT--VAQMPPQLVELPYKRSEM---KEDWQRE--------- 303
+KL ++LK + + QT V Q+ L E K SE+ KE QR+
Sbjct: 2088 QKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIE 2147
Query: 304 -LEFAFEDMYNA----DRKVKGNLILHLEPEPLPTVTNQIQDEELDLSMEQENLGAAEDL 358
LEF ++ A DRK G + +PE V Q + + +D E+E E L
Sbjct: 2148 KLEFRVRELEQALLVEDRKHFG--AVEAKPELSLEVQLQAERDAID-RKEKEITNLEEQL 2204
Query: 359 PVTEAEICSSETDVPLVMKTQQIPSKVLFKKLLNKIRSQKSLWTIKSMSEDESEMITTVS 418
E+ + +V QQ+ ++ +K + R Q+ K +D ++ +
Sbjct: 2205 EQFREELENKNEEV------QQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIK 2258
Query: 419 EIESKAPTVESGTIASKERTLSSGQEQVVESDTLTIESGPLASEDKPLSCGTNSGKEQEI 478
E ++ + T + + K + QE+ VE D L + L + L T++ +E
Sbjct: 2259 ESDAMS-TQDQHVLFGKFAQII--QEKEVEIDQLNEQVTKLQQQ---LKITTDNKVIEEK 2312
Query: 479 NETLPITTVAQSSVLLHPQEAAARIRMSARQKQIMEIEEQKQKQLELLEQ---IEQQKLR 535
NE + Q L+ QE R R +Q+ E+ E+ Q++L + Q + L
Sbjct: 2313 NELIR-DLETQIECLMSDQECVKRNR-EEEIEQLNEVIEKLQQELANIGQKTSMNAHSLS 2370
Query: 536 LETDCFRAQLEEEKRKKTQPTGVGIAPASCPVISDEDSHRQMIRNYQHQLLQQNRLHRQS 595
E D + QL+ VI+++ + Q + ++ + +++
Sbjct: 2371 EEADSLKHQLD-------------------VVIAEKLALEQQVETANEEMTFMKNVLKET 2411
Query: 596 VETARKQLLEYQTMLKGRCPSVSAPSLITDSVISV-----PSWKSERPTAISEHWDQGQR 650
QL + LK SV I ++ ++V K E ++E
Sbjct: 2412 -NFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTE-----DA 2465
Query: 651 LKLSPNKYQPIQPIQTSKLEQDHFQVARQN------HFPQRQVETTETLRASDILTNQAL 704
LK N Q +F+ +N + R ++ T+ A D+ Q
Sbjct: 2466 LKSLEN--------------QTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCY 2511
Query: 705 ESQEHLRQFSQTETQQRDYKLVPKD---SETLSRALSHDRQLISQDARKISETFGATTFQ 761
+ + +++ Q ET+ K+V E ++ AL QL +
Sbjct: 2512 KQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQL-----------------E 2554
Query: 762 SLESQQLFSENSENISYHLTEPSSFVPLVPQHSFSSLPVKVESGKIQEPFSAMSKSTVST 821
+++ F ++++ IS P+ + ++ ++ SA++ +S
Sbjct: 2555 AVQEYAKFCQDNQTISSE-----------PERTNIQNLNQLREDELGSDISALT-LRISE 2602
Query: 822 SHSIISQMHDRPLLPSENITAQQGNMKALQEQLDLQKKVLQATQEAQEQLLLCKQKEVEQ 881
S + +MH +L E + + N+ +++L +K+L+ ++ KQ+E E+
Sbjct: 2603 LESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEK--------KQREKEK 2654
Query: 882 QTGLSVFLPLVTPDSSALLPSAKADLGRIQESSPTKNNIAVSSDHHV-----ISQLQDKR 936
+ +P +L + +L E S N + V ++ ++K
Sbjct: 2655 KR---------SPQDVEVLKTT-TELFHSNEESGFFNELEALRAESVATKAELASYKEKA 2704
Query: 937 LSLSQPILSQQNNFKFLQEQLNIQKDSLQARREAQEVLYVHKQSELDRRVCSEQAEPSFP 996
L + +L ++ N LQ+ L+ +D L +E +L ++E+ + EP P
Sbjct: 2705 EKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEP-LP 2763
Query: 997 FQVAQHTFTSLPSADTKSGKIQEQHSSKSEKGL-VSCQSDIPISQDGSLSFLQQFLPLHD 1055
++++ + S Q G+ ++ QS+ S + + QF +
Sbjct: 2764 IKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSE--CSSEEVTEIISQFT---E 2818
Query: 1056 SLKLLQEQLTKQRDTLQARHEAQVELL 1082
++ +QE + +++RH ++ E L
Sbjct: 2819 KIEKMQELHAAEILDMESRHISETETL 2845
Score = 58.9 bits (141), Expect = 6e-08
Identities = 281/1512 (18%), Positives = 573/1512 (37%), Gaps = 200/1512 (13%)
Query: 405 SMSEDESEMITTVSEIESKAPTVESGTIASKERTLSSG------QEQVVESDTLTIESGP 458
S E+ E T + E+ +K E T+ K++ ++ QEQ+V+ +
Sbjct: 319 SNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQ------- 371
Query: 459 LASEDKPLSCGTNSGKEQEINETLP--ITTVAQSSVLLHPQEAAARIRMSARQKQIMEIE 516
++ L + KE++ +E + + TV + H + Q ME E
Sbjct: 372 -EIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDS-----QFETDIVQRMEQE 425
Query: 517 EQK---QKQLELLEQIEQQKLRLETDCFR---AQLEEEK-RKKTQPTGVGIAPASCPVIS 569
Q+ Q + EL E QQ ++++ + R AQ+EE K R K + + ++ V
Sbjct: 426 TQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNE 485
Query: 570 DEDSHRQMIRNYQHQLLQQNRLHRQSVETARKQLLEYQTMLKGRCPSVSAPSLITDSVIS 629
D+ + N + LQ ++ ++ +LE + L+ + L+ + S
Sbjct: 486 DQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLED-----LVEELSFS 540
Query: 630 VPSWKSERPTAISEHWDQGQRLKLSPNKYQPIQPIQTSKLEQDHFQVARQNHFPQRQVET 689
+ R T I+E Q KL+ ++ + ++ K E +R+ + + E
Sbjct: 541 REQIQRARQT-IAE-----QESKLN-EAHKSLSTVEDLKAEIVSASESRKELELKHEAEV 593
Query: 690 TETLRASDILTNQALESQEHLRQFSQTETQQRDYKLVPKDSETLSRALSHDRQLISQ-DA 748
T ++L + + + + + E ++ +L+ E LS+ L D ++ + +
Sbjct: 594 TNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSK-LKEDLEIEHRINI 652
Query: 749 RKISETFGATTFQSLESQQLFSENSENISYHLTEPSSFVPLVPQ-----HSFSSLPVKVE 803
K+ + G Q ++ Q +E S+ I E + + Q L +
Sbjct: 653 EKLKDNLGIHYKQQIDGLQ--NEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLV 710
Query: 804 SGKIQEPFSAMSKSTVSTSHSIISQMHDRPLLPSENITAQQGNMKALQEQL-----DLQK 858
+ K +E + + + I+ Q + + Q + L++Q+ DLQ+
Sbjct: 711 NSKSEE--MTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQE 768
Query: 859 KVLQATQEAQEQLLLCKQKEVEQQTGLSVFLPLVTPDSSALLPSAKADLGRIQESSPTKN 918
K Q EA+ +L ++K +E L + P+ + L S K+ + S +
Sbjct: 769 KFAQL--EAENSILKDEKKTLEDM--LKIHTPVSQEERLIFLDSIKSK----SKDSVWEK 820
Query: 919 NIAVSSDHHVISQLQDKRLSLSQPILSQQNNFKFLQEQLNIQ--------------KDSL 964
I + + + L+ + + L++ I Q+N F F ++ + KD L
Sbjct: 821 EIEILIEEN--EDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDL 878
Query: 965 QARREAQEVLYVHKQSELDRRVCSEQAEPSFPFQVAQHTF---TSLPSADTKSGKIQEQH 1021
+ + QE+ Y K L+ + ++ P+ ++ F + + + G++ E+
Sbjct: 879 EDSKNKQELEYKSKLKALNEELHLQRINPT-TVKMKSSVFDEDKTFVAETLEMGEVVEKD 937
Query: 1022 SSK-SEKGLVSCQSDIPISQDGSLSFLQQFLPLHDSLKLLQEQ---LTKQRDTLQARHEA 1077
+++ EK V+ + + +SQ S +Q H + L E+ L ++++ + R
Sbjct: 938 TTELMEKLEVTKREKLELSQRLS-DLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRE 996
Query: 1078 QVELLLHRQRDLGDSKSGLVSSSSSPVVVQHSVASQASAKAEPRRIQELYLSEKENVGPS 1137
++ H + + S VSS VV S ++ S ++ G
Sbjct: 997 LEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVS-----------KVNKSFGEE 1045
Query: 1138 CHLIIPTFQDKSLSFPQHSLAQQENLTILQEQSQIQRVILGAKEGTQEF----------- 1186
+++ +DK +SF EN+T+ +E Q Q ++ T+E
Sbjct: 1046 SKIMV---EDK-VSF--------ENMTVGEESKQEQLILDHLPSVTKESSLRATQPSEND 1093
Query: 1187 -------VHTESELEKRISSEQTGTSSSLSQVDESERFQECISIKSDSTIPLSHPKIPRC 1239
V + + R+ E SL ++ +E + + D + ++
Sbjct: 1094 KLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFA 1153
Query: 1240 QERLLRVSQHMLPLQDNLEEHQAWLDTEKEAFHFSQKTQENTSSEQTGSSSFIPQLVQLS 1299
QE ++ Q + L+ + Q D K K Q+ S E + + ++
Sbjct: 1154 QEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEY 1213
Query: 1300 FTSLASAESGTILEPLFTESESKIFSSHLQIPQLQDRLLRISQLIQPQQDNLKALQEQLA 1359
+T E + S + S + P+LQD +Q Q+N+ L ++
Sbjct: 1214 YTPALKCEVNA-----EDKENSGDYISENEDPELQDYRYE----VQDFQENMHTLLNKVT 1264
Query: 1360 TQREAIILARQEAREELLLHQSEWEGRISPEQVDTSSLPL----VPQHSFASLPLNESER 1415
E +LL+ Q+ +I +Q D L +P+ L ++
Sbjct: 1265 -----------EEYNKLLVLQTRL-SKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMT 1312
Query: 1416 NQEPCSINSDNIVSSGHS-EIPTLPDGLLGLSHLVLPQQDNLIALEEHLHAQTDFLPSIE 1474
N E +N + +SS E L + + L L+ Q L E++ A+ L
Sbjct: 1313 NLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRL 1372
Query: 1475 KTQKELVLSKPCKFEEKVSSEHFIQSHHGDLQALQQQLDTQKKAIRSIQE------VQEE 1528
+ E + + V +E D Q KK I E V+EE
Sbjct: 1373 QAVSESTVPPSLPVDSVVITE-------SDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEE 1425
Query: 1529 LLLQRLSELEKRVSSEQVCSSSFVSQVPVADSERTQKSFPTKSNDTLPSSHREIPRLQDR 1588
+ +L E + + E+ + VS + +A +++T+ S + + SS + Q
Sbjct: 1426 TNIVKLLEKQYQEQLEEEVAKVIVS-MSIAFAQQTELSRISGGKENTASSKQAHAVCQQE 1484
Query: 1589 LLSLSKPILPQQDNMTAQLDAQREVMYSYE-KPQEELSLNKQRKLNKSESAEHTIPSLFL 1647
++ L QD + Q +V + E KP + +++ S S H IP
Sbjct: 1485 QHYFNEMKL-SQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPE--- 1540
Query: 1648 PKETEHSFIPLPFAEAKPKSTCELYSSQNEHAAPPSNPVIPGFQDRLLSFSQSVLTQQDN 1707
C L S+ + + V D +S S ++Q
Sbjct: 1541 ------------------SKDCVLTISEEMFSKDKTFIVRQSIHDE-ISVSSMDASRQLM 1581
Query: 1708 LGLQKQLDLQREVLHYSQKAQEKLLVQRQTALQQQIQKHE--ETLKDFFK--DSQIS-KP 1762
L ++ D+++E++ Q+ Q+ + RQ ++Q ++ E E L++ K + Q++ +
Sbjct: 1582 LNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRS 1641
Query: 1763 TVEND-LKTQKMGQLRDWFPNTQDLAGNDQENIRHADRNNSDDNHLASEDTSAKQSGEHL 1821
+++N+ L +++ L + + L+ +E + RN+S +E+ +
Sbjct: 1642 SIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFK 1701
Query: 1822 EKDLGRRSSKPP 1833
EK+L R+ P
Sbjct: 1702 EKELDRKPEDVP 1713
Score = 58.2 bits (139), Expect = 1e-07
Identities = 325/1681 (19%), Positives = 644/1681 (38%), Gaps = 282/1681 (16%)
Query: 226 QKQAAQERMERFEKAHVRGFQAMKKIHLAQNQEKLMKELKQLQQEDLARRRQTVAQMPPQ 285
Q Q Q+ E +AH+R + + ++QE+L +E+K+L ++ LA+R
Sbjct: 1597 QYQEHQQATELLRQAHMRQMERQR-----EDQEQLQEEIKRLNRQ-LAQRSS-------- 1642
Query: 286 LVELPYKRSEMKEDWQRELEFAFEDMYNADRKVKGNLILHLEPEPLPTVTNQIQDEELDL 345
++ SE + ELE A + + A R+ + ++++
Sbjct: 1643 -IDNENLVSERERVLLEELE-ALKQLSLAGRE---------------KLCCELRNSSTQT 1685
Query: 346 SMEQENLGAAEDLPVTEAEICSSETDVPLVMKTQ-----QIPSKVLFKKLLNKIRSQKSL 400
EN G E+ E E+ DVP + + Q + L K LL ++
Sbjct: 1686 QNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVK----- 1740
Query: 401 WTIKSMSEDESEMITTVSEIESKAPTVESGTIASKERTLSSGQEQVVESDT-LTIESGPL 459
T ++ E + + + SK+ + S ++ + +S + V E T +T ES P
Sbjct: 1741 -TTAAVEETIGRHVLGILDRSSKSQS--SASLIWRSEAEASVKSCVHEEHTRVTDESIPS 1797
Query: 460 AS-EDKPLSCGTNSGKEQEINETLPITTVAQ--SSVLLHPQEAAARIRMSARQKQIME-- 514
S D P + K E L V + + P+ + +S+R + +E
Sbjct: 1798 YSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKL 1857
Query: 515 ----------IEEQKQKQLELLEQIEQQK------LRLETDCFRAQLEEEKRKKTQPTGV 558
+E K Q EL+ + +QK L+ + + R +L EE R + Q V
Sbjct: 1858 LEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEE-LRERLHEESRAREQ-LAV 1915
Query: 559 GIAPASCPVISDEDSHRQMIRNYQHQ-----------LLQQNRLHRQSVETARKQLLEYQ 607
++ A + D R Q + L NRL Q +E ++Q+ E +
Sbjct: 1916 ELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRL--QELEAEQQQIQEER 1973
Query: 608 TMLKGRCPSVSAPSLITDSVISVPSWKSERPTAISEHWD-QGQRLKLSPNKYQPIQPIQT 666
+L + ++ A + + + E + E + Q Q K+ + + ++ ++
Sbjct: 1974 ELLSRQKEAMKAEAGPVEQQLL-----QETEKLMKEKLEVQCQAEKVRDDLQKQVKALEI 2028
Query: 667 SKLEQDHFQVARQNHFPQRQVETTETLRASDILTNQALESQ-EHLRQFSQTETQQRDYKL 725
EQ V+R Q + LR NQALE Q E +R+F + R+
Sbjct: 2029 DVEEQ----VSRFIELEQEKNTELMDLRQQ----NQALEKQLEKMRKFLDEQAIDRE--- 2077
Query: 726 VPKDSETLSRALSHDRQLISQDARKISETFGATT-FQSLESQQLFSENSENISYHL---T 781
H+R + Q+ +K+ + FQ + Q + E ++ HL T
Sbjct: 2078 -------------HERDVFQQEIQKLEQQLKVVPRFQPISEHQ--TREVEQLANHLKEKT 2122
Query: 782 EPSSFVPLVPQHSFSSLPVKVES-GKIQEPFSAMSKSTVSTSHSIISQMHDRPLLPSENI 840
+ S + L + + + E K++ + ++ + + +P L E
Sbjct: 2123 DKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEV- 2181
Query: 841 TAQQGNMKALQEQLDLQKKVLQATQEAQEQL---LLCKQKEVEQQTGLSVFLPLVTPDSS 897
++A ++ +D ++K + +E EQ L K +EV+Q L + L + +S+
Sbjct: 2182 -----QLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQ---LHMQLEIQKKEST 2233
Query: 898 ALLPSAKADLGRIQESSPTKNNIAV-------SSDHHVI-----SQLQDKRLSLSQPILS 945
L + + ++ + K +A+ + D HV+ +Q+K + + Q L+
Sbjct: 2234 TRLQELEQE-NKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQ--LN 2290
Query: 946 QQNNFKFLQEQLNIQKDS--LQARREAQEVLYVHKQSELDRRVC---SEQAEPSFPFQVA 1000
+Q LQ+QL I D+ ++ + E L + + + C + + E +V
Sbjct: 2291 EQ--VTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVI 2348
Query: 1001 QHTFTSLPSADTKSGKIQEQHSSKSEKGLVSCQSDIPISQDGSLSFLQQFLPLHDSLKLL 1060
+ L + K+ HS E + Q D+ I++ L L ++
Sbjct: 2349 EKLQQELANIGQKTS--MNAHSLSEEADSLKHQLDVVIAEK---------LALEQQVETA 2397
Query: 1061 QEQLTKQRDTLQARHEAQVELL-----LHRQRDLGDSKSGLVSSSSSPVVVQHSVASQAS 1115
E++T ++ L+ + +L L R+R+ + K + +S V + H +
Sbjct: 2398 NEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVE-KIQSIPENSVNVAIDHLSKDKPE 2456
Query: 1116 AKA-------EPRRIQELYLSEKEN-VGPSCHLIIPTFQ-DKSLSFPQHSLAQ-QENLTI 1165
+ + Q + S +EN G +L Q + ++S L Q + +
Sbjct: 2457 LEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKD 2516
Query: 1166 LQEQSQIQRVILGAKEGTQEFVHTESELEKRISSEQTGT----------SSSLSQVDESE 1215
+QEQ Q + +L K + + E +S Q + ++S E
Sbjct: 2517 MQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERT 2576
Query: 1216 RFQECISIKSD---STIPLSHPKIPRCQERLLRVSQHMLPLQDNLE-EHQAWLDTEKEAF 1271
Q ++ D S I +I + +++ + ++ ++ +E + L+ EK+
Sbjct: 2577 NIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLL 2636
Query: 1272 HFSQKTQENTSSEQTGSSSFIPQLVQLSFTSL----ASAESGTILEPLFTESESKIFSSH 1327
+ + N ++ PQ V++ T+ ++ ESG E +ES ++
Sbjct: 2637 ELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAES--VATK 2694
Query: 1328 LQIPQLQDRLLRISQLIQPQQDNLKALQEQLATQREAIILARQEAREELLLHQSEWEGRI 1387
++ +++ ++ + + ++ N+ +LQ+ L+ R+ + A+++ +L + E E +
Sbjct: 2695 AELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKL--SILEKEDETEVQE 2752
Query: 1388 SPEQVDTSSLPLVPQHSFASLP---LNESERNQEP-CSINSDNIVSSGHSEIPTLPDGLL 1443
S + LP+ S AS L S NQ P + + I + SE +
Sbjct: 2753 SKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSS------ 2806
Query: 1444 GLSHLVLPQQDNLIALEEHLHAQTDFLPSIEKTQKELVLSKPCKFEEKVSSEH--FIQSH 1501
EE + F IEK Q EL ++ E + SE + H
Sbjct: 2807 ----------------EEVTEIISQFTEKIEKMQ-ELHAAEILDMESRHISETETLKREH 2849
Query: 1502 HGDLQALQQQLDTQKKAIRSIQEVQEELLLQRLSELEKRVSSEQVCSSS----------- 1550
+ +Q L+++ T K I+ ++ +E + L+ + + ++CSS
Sbjct: 2850 YVAVQLLKEECGTLKAVIQCLRS-KEGSSIPELAHSDA-YQTREICSSDSGSDWGQGIYL 2907
Query: 1551 -------FVSQVPVADSERTQKSFPTKSNDTLPSSHREIPRLQDRLLSLSKPILPQQDNM 1603
S+ +SE SFP K L + H E ++LSL++ P D
Sbjct: 2908 THSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNE----GMQVLSLTES--PYSDGE 2961
Query: 1604 TAQLDAQREVMYSYEKPQEELSLNKQRKLNKSESAEHTIPSLFLPKETEHSFIPLPFAEA 1663
+S ++ E ++ +N S + I + L +E E + E+
Sbjct: 2962 D----------HSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAE-VYDSSQSHES 3010
Query: 1664 KPKSTCELYSSQNEHAAPPSNPVIPGFQDRLLSFSQSVLTQQDNLGLQKQLD--LQREVL 1721
EL + + + ++ F+ L + L D +GL L+ +Q + +
Sbjct: 3011 FSDWRGELLLALQQVFLEERSVLLAAFRTEL-----TALGTTDAVGLLNCLEQRIQEQGV 3065
Query: 1722 HYS------QKAQEKLLVQRQTALQQQIQKHEETLKDFFKDSQISKPTVENDLKTQKMGQ 1775
Y QKA + L+ AL Q+ + TLK + + S+ +E +++ QK Q
Sbjct: 3066 EYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQ-QKQSQ 3124
Query: 1776 L 1776
+
Sbjct: 3125 M 3125
Score = 48.9 bits (115), Expect = 6e-05
Identities = 289/1536 (18%), Positives = 580/1536 (37%), Gaps = 258/1536 (16%)
Query: 255 QNQEKL---MKELKQLQQEDLARRRQTVAQMPPQLVELPYKRSEMKEDWQRELEFAFE-- 309
+ Q+KL +L Q +Q R+ Q+ Q P + + K S K D + +
Sbjct: 5 ERQKKLEAGKAKLAQFRQ----RKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQS 60
Query: 310 ---DMY-NADRKVKGNLILHLEPEPLPTVTNQIQDEELDLSMEQENLGAAEDLPVTEAEI 365
+MY N+ ++V+ +I P T+ + E+ S EQ E T A+
Sbjct: 61 QCNEMYINSSQRVESTVI------PESTIMRTLHSGEIT-SHEQGFSVELESEISTTADD 113
Query: 366 CSSETD-VPLVMKTQQIPSKVLFKKLLNKIRSQKSLWTIKSMSEDESEMITTVSEIESKA 424
CSSE + VM+T + P+ +L ++ S ++ + + + + SE+ K
Sbjct: 114 CSSEVNGCSFVMRTGK-PTNLLREEEFGVDDS----YSEQGAQDSPTHLEMMESELAGKQ 168
Query: 425 PTVESGTIASKERTLSSGQE---QVVESDTLTIESGPLASEDKPLSCGTNSGKEQEINET 481
+E +E ++ G E Q+ E + + + ++ K++ + E
Sbjct: 169 HEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREF 228
Query: 482 LPITTVAQSSVLLHPQ-EAAARIRMSAR----------QKQIMEIEEQKQKQLELLEQIE 530
L +T +Q + Q +A+ +R S ++QI+ ++Q ++Q LLE +
Sbjct: 229 LELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQ 288
Query: 531 QQKLRLETDCFRAQLEEEKRKKTQPTGVGIAPASCPVISDEDSHRQMIRNYQHQLLQQNR 590
++K E + +EK K E + + N + +Q+
Sbjct: 289 KKK---EDFTMQISFLQEKIKVY-----------------EMEQDKKVENSNKEEIQEKE 328
Query: 591 LHRQSVETARKQLLEYQTMLKGRCPSVSAPSLITDSVISVPSWKSERPTAISEHWDQGQR 650
+ + T K + E + L+ + +A L+ + + E + +
Sbjct: 329 TIIEELNT--KIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQE---------IKNMK 377
Query: 651 LKLSPNKYQPIQPIQTSKLEQDHFQVARQNHFPQRQVETTETLRASDILTNQALESQEHL 710
L+L+ +K + Q + K + ++ + Q ET DI+ E+Q L
Sbjct: 378 LELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFET-------DIVQRMEQETQRKL 430
Query: 711 RQFSQTETQQRDYKLVPKDSETLSRALSHDRQLISQDARKISETFGATTFQSLESQQLFS 770
Q + ++V E + + H Q+ R E A L S +
Sbjct: 431 EQLRAELDEMYGQQIVQMKQELIRQ---HMAQMEEMKTRHKGEMENA-----LRSYSNIT 482
Query: 771 ENSENISYHLTEPSSFVPLVPQHSFSSLPVKVESGKIQEPFSAMSKSTVSTSHSIISQMH 830
N + I + + + +K E G I E A+ + +S
Sbjct: 483 VNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEE-LSFSR 541
Query: 831 DRPLLPSENITAQQGNM----KALQEQLDLQKKVLQATQEAQEQLLLCKQKEVEQQTGLS 886
++ + I Q+ + K+L DL+ +++ A+ E++++L L + EV T
Sbjct: 542 EQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSAS-ESRKELELKHEAEV---TNYK 597
Query: 887 VFLPLVTPDSSALL----PSAKADLGRI---------QESSPTKNNIAVSSDHHV-ISQL 932
+ L ++ + +A+L S +A+L R+ +E S K ++ + +H + I +L
Sbjct: 598 IKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEI--EHRINIEKL 655
Query: 933 QDK-RLSLSQPILSQQNNFKFLQEQLNIQKDSLQARREAQEVLYVHKQSELDRRVCSEQA 991
+D + Q I QN E + +KD+L ++ Q +L + K +L + + + ++
Sbjct: 656 KDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNL-ITKQNQLILEISKLKDLQQSLVNSKS 714
Query: 992 EPSFPFQVAQHTFTSLPSADTKSGKIQEQHSSKSEKGLVSCQSDIPISQDGSLSFLQQFL 1051
E Q+ + +I+ + EKG + Q+
Sbjct: 715 E-EMTLQI-----------NELQKEIEILRQEEKEKGTLE----------------QEVQ 746
Query: 1052 PLHDSLKLLQEQLTKQRDTLQ---ARHEAQVELLLHRQRDLGDS-KSGLVSSSSSPVVVQ 1107
L +LL++Q+ ++ + LQ A+ EA+ +L ++ L D K S ++
Sbjct: 747 ELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFL 806
Query: 1108 HSVASQASAKAEPRRIQELYLSEKENVGPSCHLIIPTFQDKSLSFPQHSLAQQENLTILQ 1167
S+ S++ + I E+ + E E++ C + + + +F S A++ Q
Sbjct: 807 DSIKSKSKDSVWEKEI-EILIEENEDLKQQCIQLNEEIEKQRNTF---SFAEKNFEVNYQ 862
Query: 1168 EQSQIQRVILGAKEGTQEFVHTESELE--------------KRISSEQTGTSSSLSQVDE 1213
E + +L K+ ++ + ELE +RI+ SS+ D+
Sbjct: 863 ELQEEYACLLKVKDDLED-SKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDK 921
Query: 1214 ---SERFQECISIKSDSTIPLSHPKIPRCQERLLRVSQHMLPLQDNL------------- 1257
+E + ++ D+T + K+ + L +SQ + L + L
Sbjct: 922 TFVAETLEMGEVVEKDTTELME--KLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEE 979
Query: 1258 ------EEHQAWLDTEKEAFHFSQKTQENTSSEQTGSSSFIPQLVQLSFTSLASAESGTI 1311
E+ Q L + + EN S T SS + +V + TS + S +
Sbjct: 980 VKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVV--TMTSRGAEGSVSK 1037
Query: 1312 LEPLFTESESKIFSSHLQIPQLQDRLLRISQLIQPQQDNLKALQEQL-ATQREAIILARQ 1370
+ F E ESKI ++D++ + + + + + + L + +E+ + A Q
Sbjct: 1038 VNKSFGE-ESKI--------MVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQ 1088
Query: 1371 -----EAREELLLHQSEWEGRISPEQVDTSSLPLV-PQHSFASLPLNESERNQEPCSINS 1424
+ ++EL + +SE + L LV H E+E+++ CS+
Sbjct: 1089 PSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKE 1148
Query: 1425 DNIVSSGHS----------EIPTLPDGLLGLS----HLVLPQQDNLIALEEHLHAQTDFL 1470
+ I + E+ T+ G HL++ + ++ E QT L
Sbjct: 1149 ELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQT--L 1206
Query: 1471 PSIEKTQKELVLSKPCKFEEKVSSEHFIQSHHGDLQALQQQLDTQKKAIRSIQEVQEELL 1530
S+ L E+K +S +I + +L + ++ QE LL
Sbjct: 1207 CSVLGEYYTPALKCEVNAEDKENSGDYISENE------DPELQDYRYEVQDFQENMHTLL 1260
Query: 1531 LQRLSELEKRVSSEQVCSSSFVSQVPVADSERTQKSFPTKSNDTLPSSHREIPRLQDRLL 1590
+ E K + + S + Q E +++ P + + L S H ++ L+D +
Sbjct: 1261 NKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFL-SIHSQMTNLEDIDV 1319
Query: 1591 SLSKPILPQQDNMTAQLDAQREVMYSYEKPQEELSLNKQRKLNKSESAEHTIPSLFLPKE 1650
+ + QD +L+ Q + + E L + Q++L KE
Sbjct: 1320 NHKSKLSSLQDLEKTKLEEQVQEL-------ESLISSLQQQL----------------KE 1356
Query: 1651 TEHSFIPLPFAEAKPKSTCELYSSQNEHAAPPSNPV 1686
TE ++ EA+ + + +E PPS PV
Sbjct: 1357 TEQNY------EAEIHCLQKRLQAVSESTVPPSLPV 1386
Score = 36.6 bits (83), Expect = 0.33
Identities = 129/619 (20%), Positives = 249/619 (40%), Gaps = 128/619 (20%)
Query: 303 ELEFAFEDMYNADRKVKGNLILHLEPEPLPTVTNQIQDEELDLSMEQENLGAAEDLPVTE 362
E + A E + ADR+ +L+ ++ + Q+ ++ L EQE+ +++L E
Sbjct: 3066 EYQAAMECLQKADRR---SLLSEIQ-----ALHAQMNGRKITLKREQESEKPSQEL--LE 3115
Query: 363 AEICSSETDVPLVMKTQQIPSKVLFKKLLNKIRSQKSLWT-IKS-MSEDESEMITTVSEI 420
I ++ + L M+ + K +L ++ S+K + +KS +++ + E+ TT+
Sbjct: 3116 YNIQQKQSQM-LEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQ 3174
Query: 421 ESKAPTVESGTIASKERTLSSGQEQVVESDTLTIESGPLASEDKPLSCGTNSGKEQEINE 480
+E+ + K++T D + + + LASE K K +E+
Sbjct: 3175 HKHLKELEAFRLEVKDKT-----------DEVHLLNDTLASEQK---------KSRELQW 3214
Query: 481 TLPITTVAQSSVLLHPQEAAARIRMSARQKQIME-----IEEQKQKQLE---LLEQIE-- 530
L +E A R R K+ +E +E QKQ+ L+ LLEQ +
Sbjct: 3215 ALE-------------KEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQL 3261
Query: 531 ----QQKLRLETDCFRAQLEEEKRKK------TQPTGVGIAPASCPVISDEDSHRQ---- 576
QQK+ + + AQL EE+ + + V I S + + + H Q
Sbjct: 3262 LNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSS 3321
Query: 577 --------------MIRNYQHQLLQQ-NRLHRQSVETARKQLLEYQT---MLKGRCPSVS 618
+++ Q QL ++ +R+ ET + +L QT M K R V
Sbjct: 3322 DGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDR--QVH 3379
Query: 619 APSLITDSVISVPSWK---------SERPTAISEHWDQGQRLKLSPNKYQPI-QPIQTSK 668
+L T+ + K + + E Q +L L + Q I Q Q +
Sbjct: 3380 RKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQE 3439
Query: 669 LEQDHFQVARQNHFPQRQVETTETLRASDILTNQALESQEHLRQFSQTETQQRDY-KLVP 727
LE++ + +R+ + TT +L SD N L+ Q + ET++ +Y KL+
Sbjct: 3440 LEREEKRESRRILYQNLNEPTTWSL-TSDRTRNWVLQ------QKIEGETKESNYAKLIE 3492
Query: 728 KDSETLSRALSHDRQLISQDARKISETFGATTFQSLESQQLFSENSENISYHLTEPSSFV 787
+ +H+ ++I Q + ++ + Q L + SE + + + F+
Sbjct: 3493 MNGG--GTGCNHELEMIRQKLQCVAS----------KLQVLPQKASERLQFETADDEDFI 3540
Query: 788 PLVPQHSFSSLPVKVESGKIQEPFSAMSKSTVSTSHSIISQMHDRPLLPSENITAQQGNM 847
+ L ++ +G+ E S +S ST S + +R L + +T +
Sbjct: 3541 WVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGS------LTERLLRQNAELTGHISQL 3594
Query: 848 KALQEQLDLQKKVLQATQE 866
+E+ DL+ V++ ++
Sbjct: 3595 --TEEKNDLRNMVMKLEEQ 3611
>gi|109255234 centrosomal protein 290kDa [Homo sapiens]
Length = 2479
Score = 79.0 bits (193), Expect = 6e-14
Identities = 388/2025 (19%), Positives = 741/2025 (36%), Gaps = 329/2025 (16%)
Query: 27 ERRRKLRLLQVREQER-DIALQIREDIKQRRNQQFTR--LAEELRAEWEESQTQKIQNLE 83
E + L+ ++ E+ER D+ +IR+ ++R + T E+L SQ +I
Sbjct: 534 ENQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQGDRISE-R 592
Query: 84 KLYLASLRSMGEGH-------RQAKENEPDLDALAQRAAERKRKADLRHKEALKVQKNQK 136
KL L SL++M E R+ E E DL+ A+ + K +E ++++ K
Sbjct: 593 KLDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMK 652
Query: 137 EILLKQKTWHIKARKEALLVEKERSAKITSLPPPPPTLFENIEVKRISAV-------KTN 189
EIL +A KE + + + + P L IE K + K
Sbjct: 653 EIL--------QAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQ 704
Query: 190 SSTYHHLHTFVNRETDTKRPDARLAAEEEAK---RLEELQKQAAQERMERFEKAHVRGF- 245
+ + +E R +A +++ AK +++ L+K+ + R +G
Sbjct: 705 VDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGID 764
Query: 246 ---------------QAMKKIHLAQNQEKLMKELKQLQQ--EDLARRRQTVAQMPPQLVE 288
Q IHL Q E K+LK L+ ED R+ + L +
Sbjct: 765 LPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYK 824
Query: 289 LPYKRSEMKEDWQRELEFAFEDMYNADRKVKGNLILHLEPEPLPTVTNQIQDE------- 341
+ KE W+ E + E+ + +V+ + I E L DE
Sbjct: 825 ---EYLSEKETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILAE 881
Query: 342 -----------------------ELDLSMEQENLGAAEDLPVTEAEICSSETDVPLVMKT 378
EL+ + +EN +L EAE+C +
Sbjct: 882 NSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVCEK------IGCL 935
Query: 379 QQIPSKVLFK--KLLNKIRSQKSLWTIKSMSEDESEMITTVSEI----------ESKAPT 426
Q+ +FK L + + SL ++ ++ +E+ +I S
Sbjct: 936 QRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEH 995
Query: 427 VESGTIASKERTLSSGQEQVVESDTL-TIESGPLASEDKPLSCGTNSGKEQEINETLPIT 485
+E I+ KE+ S +E + + L TIE ++ L ++ K ++ I
Sbjct: 996 LECENISLKEQVESINKELEITKEKLHTIEQA--WEQETKLGNESSMDKAKKSITNSDIV 1053
Query: 486 TVAQSSVLLHPQEAAARIRMSARQKQIMEIEEQKQKQLELLEQIEQQKLRLETDCFR-AQ 544
++++ +L +E R R QK + L+Q+E++ LET +
Sbjct: 1054 SISKKITMLEMKELNERQRAEHCQKMYEHLRTS-------LKQMEERNFELETKFAELTK 1106
Query: 545 LEEEKRKKTQPTGVGIAPASCPVISDEDSHRQM---------------------IRNYQH 583
+ + +K Q +A + +SD D R + I Q
Sbjct: 1107 INLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNEMELKVEVSKLREISDIARRQV 1166
Query: 584 QLLQQNRLHR-QSVETARKQLLEYQTMLKGRCPSVSAPSLITDSVISVPSWKSERPTAIS 642
++L + R + VE+ R QLL+YQ +S+ + I+
Sbjct: 1167 EILNAQQQSRDKEVESLRMQLLDYQA-------------------------QSDEKSLIA 1201
Query: 643 EHWDQGQRLKLSPNKYQPIQPIQTSKLEQDHFQVARQNHFPQRQVETTETLRASDILTNQ 702
+ L+LS TSKL++ A Q+ E + L + + +
Sbjct: 1202 KLHQHNVSLQLSEATALGKLESITSKLQK---MEAYNLRLEQKLDEKEQALYYARL---E 1255
Query: 703 ALESQEHLRQFSQTETQQRDYKLVPKDSETLSRA---LSHDRQLISQDARKISETFGATT 759
+HLRQ Q+ +Q L E S+ L +D+ I Q+ + +
Sbjct: 1256 GRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNME 1315
Query: 760 FQSLESQQLFSENSENISYHLTEPSSFVPLVPQHSFSSLPVKVESGKIQE----PFSAMS 815
++LE +L + E + L + ++ H +K+E ++QE
Sbjct: 1316 NKTLE-MELKLKGLEELISTLKDTKGAQKVINWH------MKIEELRLQELKLNRELVKD 1368
Query: 816 KSTVSTSHSIISQMHDRPLLPSENITAQQG------NMKALQEQLDLQKKVLQATQEAQE 869
K + ++IIS+ ++R + E QQ M Q ++DL+++ L Q
Sbjct: 1369 KEEIKYLNNIISE-YERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQ-LDIFDRQQN 1426
Query: 870 QLLLCKQKEVEQQTGLSVFLPLVTPDSSALLPS-AKADLGRIQESSPTKNNIAVSSDHHV 928
++L QK E+ TG PD S LP+ + L +I+E N +
Sbjct: 1427 EILNAAQK-FEEATG-------SIPDPSLPLPNQLEIALRKIKE-----NIRIILETRAT 1473
Query: 929 ISQLQDKRLSLSQPILSQQNNFKFLQEQLNIQKDSLQARREAQEVLYVHKQSELDRRVCS 988
L++K + + N + +N + L A E ++++ +EL R+
Sbjct: 1474 CKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLI-----AELGRKEME 1528
Query: 989 EQAEPSFPFQVAQHTFTSLPSADTKSGKIQEQHSSKSEKGLVSCQSDIPISQDGSLSFLQ 1048
++ + ++A T ++ + + ++ +++ EK Q +I + L L
Sbjct: 1529 PKSHHT--LKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREE-QREIVKKHEEDLHILH 1585
Query: 1049 QFLPLHDSLKLLQEQLTKQRDTLQARHEAQVELLLHRQRDLGDSKSGLVSSSSSPVVVQH 1108
L L L + + T Q+ R ++ + + S SS +V
Sbjct: 1586 HRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLK 1645
Query: 1109 SVASQASAKAEPRRIQELYLSEKENVGPSCHLIIPTFQDKSLSFPQHSLAQQENLTILQE 1168
V+ + R I EL + E EN+ Q+ + A+ E+L L +
Sbjct: 1646 KVSQDLERQ---REITELKVKEFENIKLQ-------LQENHEDEVKKVKAEVEDLKYLLD 1695
Query: 1169 QSQIQRVILGAKEGTQEFVHTES-ELEKRISSEQTGTSSSLSQVDESERFQECISIKSDS 1227
QSQ + L ++ Q+ ++ + R E+ + +L + + + + ++++
Sbjct: 1696 QSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEM 1755
Query: 1228 TIPLSHPKIPRCQERLLR------VSQHMLPLQDNLEEHQAWLDTEKEAFHFSQKTQENT 1281
T I ++ V +H L+ +E+ L KEA S K +EN+
Sbjct: 1756 TAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTS-KNRENS 1814
Query: 1282 SSEQTGSSSFIPQLVQLSFTSLASAESGTILEPLFTESESKIFSSHLQIPQLQDRLLRIS 1341
++ + Q Q ++ + + E + + K +S LQ L D
Sbjct: 1815 LTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNK---Q 1871
Query: 1342 QLIQPQQDNLKALQEQLATQREAIIL---ARQEAREELLLHQ--SEWEGRISP------- 1389
LI+ Q +K L+ QL + E + L + A+EEL+ + +W+ +I
Sbjct: 1872 SLIEELQRKVKKLENQLEGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKE 1931
Query: 1390 -------------------EQVDTSSLPLVPQHSFASLPLN--------ESERNQEP--- 1419
+ D L L + + ++ ESE+ E
Sbjct: 1932 KEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKK 1991
Query: 1420 --CSINSDNIVSSGHSEIPTLPDGLLGLSHLVLPQ-QDNLIALEEHLHAQTDFLPSIEKT 1476
+ +D + H +P D ++ HL Q+ L ALE+ T PSI
Sbjct: 1992 RNLDLENDILYMRAHQALPR--DSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGI 2049
Query: 1477 QKELVLSKPCKFEEKVSSEHFIQSHHG-----DLQALQQQLDTQKKAIRSIQEVQEELLL 1531
+ + C+ E+++ E+ S L+ + L K +R ++E+ E L
Sbjct: 2050 ESD----DHCQREQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMC-EFLK 2104
Query: 1532 QRLSELEKRVSSEQVCSSSFVSQVPVADSERTQKSFP--TKSNDTLPSSHREIPRLQDRL 1589
+ +E+++++ V S R+ K+ P K+ + ++ R ++L
Sbjct: 2105 KEKAEVQRKLGH-------------VRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQL 2151
Query: 1590 LSLSKPILPQQ----DNMTAQLDAQREVMYSYEKPQEELSLNKQRKLNKSESAEHTIPSL 1645
S + ++ + +L A+ E + ++ Q + + K + AE+
Sbjct: 2152 KKASGILTSEKMANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRK 2211
Query: 1646 FLPKETEHSFIPLPFAEAKPKSTCELYSSQNEHA------APPSNPVIPGFQDRLLSFSQ 1699
L KET+ + L A+ + E + Q E A P + G + S+
Sbjct: 2212 ELKKETD-AAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSK--SWKS 2268
Query: 1700 SVLTQQDNLGLQKQLDLQREVLHYSQKAQE-KLLVQRQTALQQQIQKHEETLKDFFKDSQ 1758
V+T+ L+ +L+ ++ +Q + K LV+ T +Q++ K+ E L+ K
Sbjct: 2269 IVVTRMYETKLK---ELETDIAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIK--- 2322
Query: 1759 ISKPTVENDLKTQKMGQLRDWFPNTQDLAGNDQENIRHADRNNSDDNHLASEDTSAKQSG 1818
I K E Q + + ++ + H N D + S A Q
Sbjct: 2323 ILKHVPEGAETEQGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSGAESTIPDADQLK 2382
Query: 1819 EHLE--------KDLGRRSSKPPVAKVKCGLDLNQHELSAIQEVE 1855
E ++ DL ++ K + K+K +L + S +E+E
Sbjct: 2383 EKIKDLETQLKMSDLEKQHLKEEIKKLK--KELENFDPSFFEEIE 2425
Score = 71.2 bits (173), Expect = 1e-11
Identities = 307/1692 (18%), Positives = 638/1692 (37%), Gaps = 258/1692 (15%)
Query: 223 EELQKQAAQE---RMERFEKAHVRGFQAMKKIHLAQNQEKLMKELKQLQQE----DLARR 275
+ L K AQE +E EKA QA + L KL EL+ QQ D
Sbjct: 56 QSLMKMKAQEVELALEEVEKAGEE--QAKFENQLKTKVMKLENELEMAQQSAGGRDTRFL 113
Query: 276 RQTVAQMPPQLVELPYKRSEMKEDWQRELEFAFEDMYNADRKVKGNLILHLEPEPLPTVT 335
R + Q+ QL + + +M+++ ++E + + + N L E + L
Sbjct: 114 RNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKKN 173
Query: 336 NQIQDEELD------------LSMEQENLGAAEDLPVTEAEICSSETDVPLVMKTQQIPS 383
Q+ + +D LS E+ L E+ ++ + + +
Sbjct: 174 EQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTLTEANE--- 230
Query: 384 KVLFKKLLNKIRSQKSLWTIKSMSEDESEMITTVSEIESKAPTVESGTIASKERTLSSGQ 443
K+ + + ++S+ ++ M+++ + M V + ++ I ++ Q
Sbjct: 231 KIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDN--------VIDQLKKENDHYQ 282
Query: 444 EQVVESDTLTIESGPLASEDKPLSCGTNSGKEQE--INETLPITTVAQSSVLLHPQEAAA 501
QV E L ED P+ N+ E+ I + + +L + +E
Sbjct: 283 LQVQELTDLLKSKN---EEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLK 339
Query: 502 RIRMSARQKQIMEIEE---QKQKQLELL-EQIEQQKLRLETD-CFRAQLEEEKRKKTQPT 556
++ A + +M +++ ++ Q+++L EQ+EQ +E + C L+ E ++
Sbjct: 340 NAQLDADKSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNK--- 396
Query: 557 GVGIAPASCPVISDEDSHRQMIRNYQHQLLQQNRLHRQSVETARKQLLEYQTMLKGRCPS 616
G + S S +++ + + L K+L+E LK
Sbjct: 397 --GASTLSQQTHMKIQSTLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKDYESG 454
Query: 617 VSAPSLITDSVISVPSWKSE-----------------RPTAISEHWDQGQRLK----LSP 655
V + D+V+ + + K++ IS+ D+ + L+ L P
Sbjct: 455 VYG---LEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVGLEP 511
Query: 656 NKYQPIQPIQTSK-LEQDHFQVARQNHFPQRQVETTETLR------------------AS 696
+ + SK L+Q ++ +N +++E+ E R A+
Sbjct: 512 KTMIDLTEFRNSKHLKQQQYRA--ENQILLKEIESLEEERLDLKKKIRQMAQERGKRSAT 569
Query: 697 DILTNQALESQEHLRQFSQTETQQRDYKLVPKDSETLSRALSHDRQLISQD-----ARKI 751
LT + L E++ Q + ++ D + SE S+ R+LI ++ +R +
Sbjct: 570 SGLTTEDLNLTENISQGDRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRTV 629
Query: 752 SETFGATTFQSLESQQLFSENSENISYHLTEPSSFVPLVPQHSFSSLPVKVESGKIQEPF 811
F + +E + E + I + E V+ G+
Sbjct: 630 IAKFQNKLKELVEENKQLEEGMKEILQAIKEMQK-------------DPDVKGGETSLII 676
Query: 812 SAMSKSTVSTSHSIISQMHDRPLLPSENITAQQGNMKALQEQL-DLQKKVLQATQEAQEQ 870
++ + + + D L + G + L+++L + +K+ + +Q+ +
Sbjct: 677 PSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKA 736
Query: 871 LLLCKQKEVEQQTGLS--------VFLPLVTPDSSALLPSAKADLGRIQESSPTKNNIAV 922
L K +E++T L VF + PD A P+ +I
Sbjct: 737 NL--KIDHLEKETSLLRQSEGSNVVFKGIDLPDGIA----------------PSSASIIN 778
Query: 923 SSDHHVISQLQDKRLSLSQPILSQQNNFKFLQEQLNIQKDSLQARREAQEVLYVHKQSEL 982
S + ++I LQ+ + +++ K L++ L R Q +LY SE
Sbjct: 779 SQNEYLIHLLQE--------LENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEK 830
Query: 983 D-------------RRVCSEQAEPSFPFQVAQHTFTSLPSADTKSGKIQEQHSSKSEKGL 1029
+ R++ + + + + + +L + KI ++S K
Sbjct: 831 ETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRK----- 885
Query: 1030 VSCQSDIPISQDGSLSFLQQFLPLHDSLKLLQEQLTKQRDTLQARHEAQVELL--LHRQR 1087
I + Q S ++Q+ L + + L+++ KQ++ L + E + L R +
Sbjct: 886 ------ITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFK 939
Query: 1088 DLGDSKSGLVSSSSSPVVVQHSVASQASAKAEPRRIQELYLSEKENVGPSCHLIIPTFQD 1147
++ K + VV +SV S + + ++ EL ++ + L+ T
Sbjct: 940 EMAIFKIAALQK-----VVDNSV-SLSELELANKQYNELTAKYRDILQKDNMLVQRTSNL 993
Query: 1148 KSLSFPQHSLAQQENLTILQEQSQIQRVILGAKEGTQEFVHTESELEKRISSEQTGTSSS 1207
+ L + EN+++ ++ I + + E T+E +HT + ++ + G SS
Sbjct: 994 EHL--------ECENISLKEQVESINKEL----EITKEKLHTIEQAWEQ--ETKLGNESS 1039
Query: 1208 LSQVDESERFQECISIKSDSTIPLSHPKIPRCQ--ERLLRVSQHMLPLQDNLEEHQAWLD 1265
+ + +S + +SI T+ L ++ Q E ++ +H+ +EE L+
Sbjct: 1040 MDKAKKSITNSDIVSISKKITM-LEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELE 1098
Query: 1266 TEKEAFHFSQKTQENTSSEQTGSSSFIPQLVQLSFTSLASAESGTILEPLFTESESKIFS 1325
T+ F++ T+ N +++ +L +++ A+ ILE E E K+
Sbjct: 1099 TK-----FAELTKINLDAQKV-EQMLRDELADSVSKAVSDADRQRILELEKNEMELKVEV 1152
Query: 1326 SHLQIPQLQDRLLRISQLIQPQQDN---------LKALQEQLATQREAIILARQEAREEL 1376
S L+ ++ D R +++ QQ + ++ L Q + +++I + L
Sbjct: 1153 SKLR--EISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSL 1210
Query: 1377 LLHQSEWEGRISPEQVDTSSLPLVPQHSFASLPLNESERNQEPCSINSDNIVSSGHSEIP 1436
L ++ G++ E + + + + L+E E+ + N I
Sbjct: 1211 QLSEATALGKL--ESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQ 1268
Query: 1437 TLP---DGLLGLSH-------LVLPQQDNLIALEEHLHAQTDFLPSIEKT-QKELVLSKP 1485
+L G L L+ ++ Q D L ++E ++Q + KT + EL L
Sbjct: 1269 SLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKG- 1327
Query: 1486 CKFEEKVSS-------EHFIQSHHGDLQALQQQLDTQKKAIRSIQEVQEELLLQRLSELE 1538
EE +S+ + I H + Q+L ++ ++ +E++ L +SE E
Sbjct: 1328 --LEELISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVKDKEEIK--YLNNIISEYE 1383
Query: 1539 KRVSS---EQVCSSSFVSQVPVA------DSERTQKSFPTKSNDTLPSSHREIPRLQDRL 1589
+ +SS E V + F + +A D ER F + N+ L ++ + ++
Sbjct: 1384 RTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQK----FEEAT 1439
Query: 1590 LSLSKPILPQQDNMTAQLDAQREVMYSYEKPQEELSLNKQRKLNKSESAEHTIPSLFLPK 1649
S+ P LP + + L +E + + + + + KL + ESA L +
Sbjct: 1440 GSIPDPSLPLPNQLEIALRKIKENIRIILETRATCK-SLEEKLKEKESALRLAEQNILSR 1498
Query: 1650 ET--EHSFIPLPFAEAKPKSTCELYSSQNE----HAAPPSNPVIPGFQDRLLSFSQSVLT 1703
+ + LP + K EL + E H ++ I Q RL + + VL
Sbjct: 1499 DKVINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARL-NQKEEVLK 1557
Query: 1704 QQDNLGLQKQLDLQREVLHYSQKAQEKLLVQRQTALQQQIQKHEETLKDFFKDSQISKPT 1763
+ L L+K + QRE++ ++ L + + + K ++T D K S PT
Sbjct: 1558 KYQRL-LEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPT 1616
Query: 1764 VENDLKTQKMGQ 1775
++ ++ +M Q
Sbjct: 1617 NKHFIRLAEMEQ 1628
Score = 34.3 bits (77), Expect = 1.6
Identities = 107/566 (18%), Positives = 236/566 (41%), Gaps = 63/566 (11%)
Query: 23 KEDYERRRKLRLLQVREQERDIALQIREDI----KQRRNQQFTRLAEELRAEWE---ESQ 75
KE+ ++ + L + RE++R+I + ED+ + Q + L + + W+ +S
Sbjct: 1552 KEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSP 1611
Query: 76 TQKIQNLEKLYLASL-RSMGEGHRQAKENEPDLDALAQRAAERKRKADLRHKE----ALK 130
T N + LA + +++ E L ++Q ++ +L+ KE L+
Sbjct: 1612 TPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQ 1671
Query: 131 VQKNQKEILLKQKT-------WHIKARKEALLVEKERSAKITSLPPPPPTLFENIEVKRI 183
+Q+N ++ + K K +++KE+ ++ E A+ + P T N+ +
Sbjct: 1672 LQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNL----V 1727
Query: 184 SAVKTNSSTYHHLHTFVNRETDTKRPDARLAAEEEAKRLEELQKQAAQERMERFEKAHVR 243
+K+ + ++R R + AAEE + + ++ A +++ H R
Sbjct: 1728 ERLKSQLALKEKQQKALSRALLELRAEMTAAAEE--RIISATSQKEAHLNVQQIVDRHTR 1785
Query: 244 GFQAMKKIHLAQNQEKLMKELKQLQQEDLARRRQTVAQMPPQLVELPYKRSEMKEDWQRE 303
+ + L +N KL + LK + R ++ L K+ + RE
Sbjct: 1786 ELKTQVE-DLNENLLKLKEALKTSK-----NRENSLTDNLNDLNNELQKKQKAYNKILRE 1839
Query: 304 LEFAFEDMYNADRKVKGNLILHLEPEPLPTVTNQIQDEELD---LSMEQENLGAAEDLPV 360
E ++ R++K L L+ +PL T Q EEL +E + G E++ +
Sbjct: 1840 KEEIDQENDELKRQIK-RLTSGLQGKPL-TDNKQSLIEELQRKVKKLENQLEGKVEEVDL 1897
Query: 361 TEAEICSSETDVPLVMKTQQIPSKVLFKKLLNKIRSQK-SLWTIKSMSEDESEMITTVSE 419
+ +++ ++ + ++ +K+ + + NK++ ++ ++T+ ++ + T+ +
Sbjct: 1898 KPMKEKNAKEELIRWEEGKKWQAKI--EGIRNKLKEKEGEVFTL-------TKQLNTLKD 1948
Query: 420 IESKAPTVESGTIASKERTLSSGQEQVVESDTLTIESGPLASEDKPLSCGTNSGKEQEIN 479
+ +KA E T+ K +T +QV+ L E + + L N +
Sbjct: 1949 LFAKADK-EKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDL-ENDILYMRAH 2006
Query: 480 ETLPITTVAQSSVLLHPQEAAARIRMSARQKQ----------IMEIEEQKQKQLELLEQI 529
+ LP +V + LH Q + ++ A +KQ I IE Q E +++
Sbjct: 2007 QALPRDSVVED---LHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQRE--QEL 2061
Query: 530 EQQKLRLETDCFRAQLEEEKRKKTQP 555
+++ L+L ++ + + E+ K P
Sbjct: 2062 QKENLKLSSENIELKFQLEQANKDLP 2087
Score = 32.7 bits (73), Expect = 4.8
Identities = 100/575 (17%), Positives = 229/575 (39%), Gaps = 62/575 (10%)
Query: 2 KRKVVNTHKLRLSPNEEAFILKEDYERRRK---------LRLLQVREQERDIALQIREDI 52
K+ + N+ + +S +KE ER+R LR + +ER+ L+ +
Sbjct: 1044 KKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFAE 1103
Query: 53 KQRRNQQFTRLAEELRAEWEESQTQKIQNLEKLYLASLRSMGEGHRQAKENEPDLDALAQ 112
+ N ++ + LR E +S ++ + + ++ + L + E + ++ L +
Sbjct: 1104 LTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELE------KNEMELKVEVSKLRE 1157
Query: 113 RAAERKRKADLRHKEALKVQKNQKEILLKQKTWHIKARKEALLVEKERSAKITSLPPPPP 172
+ +R+ ++ + + K + + ++ + ++ +++L+ + + L
Sbjct: 1158 ISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLS---- 1213
Query: 173 TLFENIEVKRISAVKTNSSTYHHLHTFVNRETDTKRPD---ARLAAEEEAKRLEELQKQA 229
E + ++ ++ + + + ++ D K ARL AK L + +
Sbjct: 1214 ---EATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSL 1270
Query: 230 AQERMERFEKAHVRGFQAMKKIHLAQNQEKLMKELKQLQQEDLARRRQTVAQMPPQLVEL 289
++ A F + I L ++ K+M+E+K QQE +T+ +M +L L
Sbjct: 1271 RRQFSGALPLAQQEKF-SKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTL-EMELKLKGL 1328
Query: 290 PYKRSEMKE--DWQRELEFAFEDMYNADRKVKGNLILHLEPEPLPTVTNQIQDEELDLSM 347
S +K+ Q+ + + + +++K N L + E + + N I + E +S
Sbjct: 1329 EELISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVKDKEEIKYLNNIISEYERTISS 1388
Query: 348 EQENLGAAEDLPVTEAEICSSETDVPL-----------------VMKTQQIPSKVLFKKL 390
+E + ++ E ++ + +V L K ++ + L
Sbjct: 1389 LEEEI-VQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSL 1447
Query: 391 LNKIRSQKSLWTIKSMSEDESEMITTVSEIESKAPTVESGTIASKERTLSSGQEQVVESD 450
+ + +L IK E T +E K ES +++ LS +++V+ +
Sbjct: 1448 PLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILS--RDKVI--N 1503
Query: 451 TLTIESGPLASEDKPLSCGTNSGKEQEINETLPIT--TVAQSSVLLHPQEAA----ARIR 504
L + A +K ++ E + + TL I T+A L+ +E R+
Sbjct: 1504 ELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRLL 1563
Query: 505 MSARQKQIMEIEEQKQKQLELLEQIEQQKLRLETD 539
AR++Q EI ++ ++ L +L +L L+ D
Sbjct: 1564 EKAREEQ-REIVKKHEEDLHIL----HHRLELQAD 1593
Score = 32.0 bits (71), Expect = 8.2
Identities = 35/150 (23%), Positives = 62/150 (41%), Gaps = 12/150 (8%)
Query: 2454 SELSIEKPRTASTETPRRLTPVPGSLQEAFIKRKKSFMERSHQRQKEIRNKIHVSENS-- 2511
S L I K +T E L EA + K + + +R K+ + ++ E++
Sbjct: 411 STLDILKEKTKEAERTAELA-------EADAREKDKELVEALKRLKDYESGVYGLEDAVV 463
Query: 2512 QIKTVKEKPSISSSVSRL--KGVNKVRASFPEDRKTTQALRHQRGLRLYNQLAEVKQQKE 2569
+IK K + I + K +NK+ + +ALR + GL + + +
Sbjct: 464 EIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVGLEPKTMIDLTEFRNS 523
Query: 2570 EKTKQEAY-AQNRARAKEFHKKTLEKLRAK 2598
+ KQ+ Y A+N+ KE E+L K
Sbjct: 524 KHLKQQQYRAENQILLKEIESLEEERLDLK 553
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 77.8 bits (190), Expect = 1e-13
Identities = 300/1671 (17%), Positives = 625/1671 (37%), Gaps = 216/1671 (12%)
Query: 1 MKRKVVNTHKLRLSPNEEAFILKEDYERRRKLRLLQVREQERDIALQIREDIKQRRNQQF 60
++RK + + E +E E RR+ +L + +E+ R+ L+ RE ++RR QQ
Sbjct: 306 LRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLR-REQEEERREQQL 364
Query: 61 TRLAEELRAEWEESQTQKIQNLEKLYLASLRSMGEGHRQAKENEPDLDALAQRAAERKRK 120
R EE R E + + Q+++ ++L R Q E L +R + +R+
Sbjct: 365 RREQEEERREQQLRREQQLRREQQL----RREQQLRREQQLRREQQL----RREQQLRRE 416
Query: 121 ADLRHKEALKVQKNQKEILLKQKTWHIKARKEALLVEKERSAKITSLPPPPPTLFENIEV 180
LR ++ L+ + Q+E +QK H + R+E L ++E+ + L T E E
Sbjct: 417 QQLRREQQLR--REQEEERHEQK--HEQERREQRL-KREQEERRDWLKREEET--ERHEQ 469
Query: 181 KRISAVKTNSSTYHHLHTFVNRETDTKRP-----DARLAAEEEAKRLEELQKQAAQERME 235
+R ++ E + +R + +L E+E +R + L++Q +ER++
Sbjct: 470 ERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQ 529
Query: 236 ---RFEKAHVRGFQAMKKIHLAQNQEKLMKE------LKQLQQE--------DLARRRQT 278
R E+ R + ++ L + +EK +++ LK+ Q+E + RR+Q
Sbjct: 530 QRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQR 589
Query: 279 VAQMPPQLVELPYKRSE---MKEDWQRELEFAFEDMYNADRK--VKGNLILHLEPEPLPT 333
+ + + +E KR E ++++ +RE E+ R+ +K + L
Sbjct: 590 LKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRR 649
Query: 334 VTNQIQDEELDLSMEQE----NLGAAEDLPVTEAEICSSETDVPLVMKTQQIP------- 382
+ +++ L E+E L + E E+ E + +IP
Sbjct: 650 EQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLE 709
Query: 383 --SKVLFKKLLNKIRSQKSLWTIKSMSEDESEMITTVSEI----ESKAPTVESGTIASKE 436
+ K+ ++ R Q+ + E E + SE+ E +A + ++
Sbjct: 710 SEADARQSKVYSRPRKQEGQ---RRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRD 766
Query: 437 RTLSSGQEQVVESDTLTIESGPLASEDKPLSCGTNSGKEQEINETLPITTVAQSSVLLHP 496
T E+ E + + P E + +++E Q +
Sbjct: 767 FTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQRE-----------QRFLPEEE 815
Query: 497 QEAAARIRMSARQKQIMEIEEQKQKQ-LELLEQIEQQKLRLETD-------------CFR 542
++ R + R+K++ +EE++Q Q E +Q+++++ L+ D +R
Sbjct: 816 EKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWR 875
Query: 543 AQLEEEKRKKTQPTGVGIAPASCPVISDEDSHRQMIRNYQHQLLQQNRLHRQSVETARKQ 602
QLEEE++++ + P + ++ Q + + + LQ+ ++ + +Q
Sbjct: 876 WQLEEERKRRRHTL------YAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQ 929
Query: 603 LLEYQTMLKGRCPSVSAPSLITDSVISVPSWKSERPTAISEHWDQGQRLKLSPNKYQPIQ 662
E + + + + ++ ++ E G+ + + + +
Sbjct: 930 YREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKK 989
Query: 663 PIQTSKLEQDHFQVARQNHFPQRQVETTETLRASDILTNQALE----------SQEHLRQ 712
+ +L+Q+ Q+ R+ +R+ E R D L + + QE RQ
Sbjct: 990 YREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQ 1049
Query: 713 F-SQTETQQRDYKLVPKDSET-----LSRALSHDRQLISQDARKISETFGATTFQSLESQ 766
+ + E QQ + +L+ ++ ET L R + +L ++ + + E Q E Q
Sbjct: 1050 YREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQ 1109
Query: 767 ----QLFSENSENISYHLTEPSSFVPLVPQHSFSSLPVKVESGKIQEPFSAMSKSTVSTS 822
+ + E + E L Q+ + E ++E + +
Sbjct: 1110 CREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQ 1169
Query: 823 HSIIS--QMHDRPLLPSENITAQQGNMKALQEQLDLQK-KVLQATQEAQEQLLLCKQKEV 879
+ Q + LL E +Q + +E+ +LQ+ K Q ++ ++ L Q E
Sbjct: 1170 YREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEP 1229
Query: 880 EQQTGLSVFLPLVTPDSSALLPSAKADLGRIQESSPTKNNIAVSSDHHVISQLQDKRLSL 939
E++ + D+ + + R E S ++ + H++ + Q++
Sbjct: 1230 EKENAVR--------DNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQ 1281
Query: 940 SQPILSQQNNFKFLQEQL--NIQKDSLQARREAQEVLYV--------HKQSELDRRVCSE 989
+ Q++ +EQL QK++ + R++QE + ++ E DR+ E
Sbjct: 1282 ERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREE 1341
Query: 990 QAEPSFPFQVAQHTFTSLPSADTKSGKIQEQHSSKSEKGLVSCQSDIPI-SQDGSLSFLQ 1048
+ Q+ Q + K +E+ E+G + + + Q+ FL+
Sbjct: 1342 E-------QLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLK 1394
Query: 1049 QFLPLH-------------DSLKLLQEQLTKQRDTLQARHEAQVELLLHRQRDLGDSKSG 1095
+ L + ++QL++Q + R E Q R+R + +
Sbjct: 1395 EEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQ 1454
Query: 1096 LVSSSSSPVVVQHSVASQASAKAEPRRIQELYLSEKENVGPSCHLIIPTFQDKSLSFPQH 1155
L +H + + R Q+L+ E++ + Q++ F +
Sbjct: 1455 LRQE-------RHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRR-QERDRKFREQ 1506
Query: 1156 SLAQQE-NLTILQEQSQIQRVILGAKEGTQEFVHTESELEKRISSEQTGTSSSL-----S 1209
L QE L+E+ Q+ R ++ ++F+ E +L ++ +Q
Sbjct: 1507 ELRSQEPERKFLEEEQQLHR-----QQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEE 1561
Query: 1210 QVDESERFQECISIKSDSTIPLSHPKIPRC-QERLLRVSQHMLPLQDNLEEHQAWLDTE- 1267
Q+ + Q+ + D L K+ R QER + L Q+ ++ + D +
Sbjct: 1562 QLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKF 1621
Query: 1268 KEAFHFSQKTQENTSSEQTGSSSFIPQLVQLSFTSLASAESGTILEPLFTESESKIFSSH 1327
+E Q+ +E Q F+ + QL + + F E E +
Sbjct: 1622 REDEQLLQEREEQQLHRQERDRKFLEEEPQLR-RQEREQQLRHDRDRKFREEEQLLQEGE 1680
Query: 1328 LQIPQLQDRLLRI---SQLIQPQQDNLKALQEQLATQREAI-------ILARQEAREELL 1377
Q + Q+R + Q ++ Q+ K LQE+ +R+ + RQE +E L
Sbjct: 1681 EQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQL 1740
Query: 1378 LHQSEWEGRISPEQVDTSSLPLVPQHSFASLPLNESERNQEPCSINSDNIVSSGHSEIPT 1437
Q + + EQ L P+ L E +R + + E
Sbjct: 1741 RRQERYRKILEEEQ-------LRPEREEQQLRRQERDR-----KFREEEQLRQEREE--- 1785
Query: 1438 LPDGLLGLSHLVLPQQDNLIALEEHLHAQTD--FLPSIEKTQKELVLSKPCKFEEKVSSE 1495
L + D EE L + + L ++ K + + EE+ E
Sbjct: 1786 --------QQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQ---E 1834
Query: 1496 HFIQSHHGDLQALQQQLDTQKKAIRSIQEVQEELLLQRLSELEKRVSSEQV 1546
++ ++Q TQ+K+ R QE+ +E +R E E+++ E +
Sbjct: 1835 QRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHI 1885
Score = 72.8 bits (177), Expect = 4e-12
Identities = 340/1902 (17%), Positives = 705/1902 (37%), Gaps = 310/1902 (16%)
Query: 23 KEDYERRRKLRLLQVREQERDIALQIREDIKQRRNQQFTRLA--EEL---RAEWEESQTQ 77
+E +RRR+ R +EQER++A + KQ R +Q R EEL R EW+E + +
Sbjct: 131 EEPGQRRRQKR----QEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREER 186
Query: 78 KI-------------------QNLEKLYLASLRSMGEGHRQAKENEPDLDALAQRAAE-- 116
+ + L + L LR G +Q + E D + Q E
Sbjct: 187 RAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQ-DRVFQEEEEKE 245
Query: 117 -RKRKADLR-HKEALKVQKNQKEILLKQKTWHI-KARKEALLVEKERSAKITSLPPPPPT 173
RKR+ LR +E L+ ++ Q++ L+++ + K ++ L E++ +
Sbjct: 246 WRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQ------QQQR 299
Query: 174 LFENIEVKRISAVKTNSSTYHHLHTFVNRETDTKRPDARLAAEEEAKRLEELQKQAAQER 233
L +++R + RE +R + +L E+E +R ++L+++ +ER
Sbjct: 300 LRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEER 359
Query: 234 ME---RFEKAHVRGFQAMKKIHLAQNQEKLMKELKQLQQEDLARRRQTVAQMPPQLVELP 290
E R E+ R Q +++ + +++L +E +QL++E RR Q + +
Sbjct: 360 REQQLRREQEEERREQQLRREQQLRREQQLRRE-QQLRREQQLRREQQLRR--------- 409
Query: 291 YKRSEMKEDWQRELEFAFEDMYNADRKVKGNLILHLEPEPLPTVTNQIQDEELDLSMEQE 350
++ +RE + E +++ + + H E E + Q+E D +E
Sbjct: 410 ------EQQLRREQQLRREQQLRREQEEERHEQKH-EQERREQRLKREQEERRDWLKREE 462
Query: 351 NLGAAEDLPVTEAEICSSETDVPLVMKTQQIPSKVLFKKLLNKIRSQKSLWTIKSMSEDE 410
E E E + + Q+ + + KL + R ++ + + ++
Sbjct: 463 -----------ETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQ 511
Query: 411 SEMITTVSEIESKAPTVESGTIASKE--RTLSSGQEQVVESDTLTIESGPLASEDKPLSC 468
E + + + ++ + ++ R +EQ+++ + E+K L
Sbjct: 512 EERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKRE-----------EEKRL-- 558
Query: 469 GTNSGKEQEINETLPITTVAQSSVLLHPQEAAARIRMSARQKQIMEIEEQKQKQLELLEQ 528
+++ + L + LL +E + R+ Q++ +E + K++++E LEQ
Sbjct: 559 -----EQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLE-QRLKREEVERLEQ 612
Query: 529 IEQQKLRLETDCFRAQLEEEKRKKTQPTGVGIAPASCPVISDEDSHRQMIRNYQHQLLQQ 588
E+++ RL+ R + EEE+R++ + +++ RQ + Q ++
Sbjct: 613 EERREQRLK----REEPEEERRQQLLKS------------EEQEERRQQQLRREQQERRE 656
Query: 589 NRLHRQSVETARKQLLEYQTMLKGRCPSVSAPSLITDSVISVPSWKSERPTAISEHWDQG 648
RL R+ E +Q L+ + + R E+ A E
Sbjct: 657 QRLKREEEEERLEQRLKREHEEERR----------------------EQELAEEEQEQAR 694
Query: 649 QRLKLSPNKYQPIQPIQTSKLEQDHFQVARQNHFPQRQVETTETLRASDILTNQALESQE 708
+R+K K+Q + + + R+ +R+ E E R + E +
Sbjct: 695 ERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERA 754
Query: 709 HLRQFSQTETQQRDYK---LVPKDSETLSRALS--------HDRQLISQDARKISETFGA 757
H +Q Q E Q+RD+ + SE + LS +RQL +++ ++ + F
Sbjct: 755 HRQQ--QEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLP 812
Query: 758 TTFQSLESQQLFSENSENISYHLTEPSSFVPLVPQHSFSSLPVKVESGKIQEPFSAMSKS 817
+ + ++ E + + + L E Q + ++ E +QE
Sbjct: 813 EEEEKEQRRRQRREREKELQF-LEEEEQL-----QRRERAQQLQEEEDGLQEDQERRRSQ 866
Query: 818 TVSTSHSIISQMHDRPLLPSENITAQQGNMKALQEQLDLQKKVLQATQEAQEQLLLCKQK 877
Q+ + + A+ ALQEQL ++++LQ +E ++ K++
Sbjct: 867 EQRRDQKWRWQLEEERKRRRHTLYAK----PALQEQLRKEQQLLQEEEEELQREEREKRR 922
Query: 878 EVEQQTGLSVFLPLVTPDSSALLPSAKADLGRIQESSPTKNNIAVSSDHHVISQLQDKRL 937
EQ+ L + L + + +E K+ + ++ + +KR
Sbjct: 923 RQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKR- 981
Query: 938 SLSQPILSQQNNFKFLQEQLNIQKDSLQARREAQEVLYVHKQSELDRRVCSEQAEPSFPF 997
+Q K +E+ +Q++ Q RE +E ++ E +R+ +
Sbjct: 982 -------RRQEREKKYREEEELQQEEEQLLREERE---KRRRQEWERQYRKKDELQQEEE 1031
Query: 998 QVAQHTFTSLPSADTKSGKIQEQHSSKSEKGLVSCQSDIPISQDGSLSFLQQFLPLHDSL 1057
Q+ + + + +E+ + E+ L+ + + Q+ + ++ +
Sbjct: 1032 QLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEE 1091
Query: 1058 KLLQEQLTKQR---DTLQARHEAQV----ELLLHRQRDLGDSKSGLVSSSSSPVVVQHSV 1110
+LL+E+ K+R Q R E ++ E LL +R+ + L VQ
Sbjct: 1092 QLLREEPEKRRRQERERQCREEEELQQEEEQLLREERE-KRRRQELERQYREEEEVQQEE 1150
Query: 1111 ASQASAKAEPRRIQELYLSEKENVGPSCHLIIPTFQDKSLSFPQHSLAQQENLTILQEQS 1170
+ E RR QEL +E + L Q+E + +EQ
Sbjct: 1151 EQLLREEPEKRRRQELERQYRE---------------------EEELQQEEEQLLREEQE 1189
Query: 1171 QIQRVILGAKEGTQEFVHTESELEKRISSEQTGTSSSLSQVDESERFQECISIKSDSTI- 1229
+ ++ + E EL+++ ++ S + ++ +++ +
Sbjct: 1190 K-------RRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYC 1242
Query: 1230 -PLSHPKIPRCQERLLRVSQHMLPLQDNLEEHQAWLDTEKEAFHFSQKTQENTSSEQTGS 1288
+ + + ++ LR Q LQ L E Q D E+E + Q+ + EQ
Sbjct: 1243 KGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQE-RDREQERRRWQQRDRHFPEEEQLER 1301
Query: 1289 SSFIPQLVQLSFTSLASAESGTILEPLFTESESKIFSSHLQIPQLQDRLLRISQLIQPQQ 1348
+ E+K Q + R R + + +
Sbjct: 1302 EE---------------------------QKEAKRRDRKSQEEKQLLREEREEKRRRQET 1334
Query: 1349 DNLKALQEQLATQREAIILARQEA----REELLLHQS------EWEGRISPEQVDTSSLP 1398
D +EQL +RE L RQE REE L HQ E E R+ ++ + L
Sbjct: 1335 DRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLK 1394
Query: 1399 LVPQHSFASLPLNESERNQEPCSINSDNIVSSGHSEIPTLPDGLLGLSHLVLPQQDNLIA 1458
Q L ER Q+ + D E L ++D
Sbjct: 1395 EEQQ-------LRCQEREQQ---LRQDRDRKFREEE-----------QQLSRQERDRKFR 1433
Query: 1459 LEEHLHAQTDFLPSIEKTQKELVLSKPCKFEEKVSSEHFIQSHHGDLQALQQQLDTQKKA 1518
EE + + + +++L + KF E+ E +Q +QQL Q++
Sbjct: 1434 EEEQQVRRQERERKFLEEEQQLRQERHRKFREE---EQLLQERE------EQQLHRQERD 1484
Query: 1519 IRSIQEVQEELLLQRLSELEKRVSSEQVCSSSFVSQVPVADSERTQKSFPTKSNDTLPSS 1578
+ ++E Q+ +R + ++ Q F+ + ++ Q+ F + L
Sbjct: 1485 RKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKF-LQEEQQLRRQ 1543
Query: 1579 HREIPRLQDRLLSLSKPILPQQDNMTAQLDAQ-REVMYSYE------KPQEELSLNKQRK 1631
R R QDR + +Q+ QL Q R+ + E + QE + +++
Sbjct: 1544 ERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQ 1603
Query: 1632 LNKSESAEHTIPSLFLPKETEHSFIPLPFAEAKPKSTCELYSSQNEHAAPPSNPVIPGFQ 1691
L + E + L +E + F + + +L+ + + P + +
Sbjct: 1604 LRRQEGQQQ------LRQERDRKFRE-DEQLLQEREEQQLHRQERDRKFLEEEPQLRRQE 1656
Query: 1692 -------DRLLSFSQSVLTQQDNLGLQKQLDLQREVLHYSQKAQEKLLVQRQTALQQQIQ 1744
DR F + Q+ G ++QL Q + ++ Q+ +R+ Q+ Q
Sbjct: 1657 REQQLRHDRDRKFREEEQLLQE--GEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQ 1714
Query: 1745 --KHEETLKDFFKDSQISKPTVENDLKTQKMGQLRDWFPNTQDLAGNDQENIRHADRNNS 1802
+ +E + F ++ Q+ + T + L+ Q+ + R Q +++ +R +R+
Sbjct: 1715 QLRRQELERKFREEEQLRQETEQEQLRRQE--RYRKILEEEQLRPEREEQQLRRQERDRK 1772
Query: 1803 -----------DDNHLASEDTSAK-QSGEHLEKDLGRRSSKP 1832
++ L S+++ K + E L ++ + +P
Sbjct: 1773 FREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRP 1814
Score = 55.1 bits (131), Expect = 9e-07
Identities = 151/771 (19%), Positives = 299/771 (38%), Gaps = 111/771 (14%)
Query: 17 EEAFILKEDYERRRKLRLLQVREQERDIALQIREDIKQRRNQQFTRLAEELRAEWEESQT 76
EE +L+E+ E+RR+ R Q RE+E LQ R+ KQR + R +L+ +WE +
Sbjct: 1179 EEEQLLREEQEKRRQERERQYREEEE---LQ-RQKRKQRYRDEDQR--SDLKWQWEPEKE 1232
Query: 77 QKIQNLEKLYLAS-----LRSMGEGHRQAKENEPDLDALAQRAAERKRKADLRH------ 125
+++ K+Y R + + + ++++ DL L ER R+ + R
Sbjct: 1233 NAVRD-NKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDR 1291
Query: 126 ---KEALKVQKNQKEILLKQKTWHIKARKEALLVEKERSAKITSLPPP-----PPTLFEN 177
+E ++ QKE + + K+++E L+ +ER K L +
Sbjct: 1292 HFPEEEQLEREEQKEAKRRDR----KSQEEKQLLREEREEKRRRQETDRKFREEEQLLQE 1347
Query: 178 IEVKRISAV----KTNSSTYHHLHT---FVNRETDTKRPDA--RLAAEEEAKRLEELQKQ 228
E + + K H F+ E +R + + EE+ R +E ++Q
Sbjct: 1348 REEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQ 1407
Query: 229 AAQERMERFEKAHV--------RGF-QAMKKIHLAQNQEKLMKELKQLQQEDLARRRQTV 279
Q+R +F + R F + +++ + + K ++E +QL+QE + R+
Sbjct: 1408 LRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEE 1467
Query: 280 AQMPPQLVELPYKRSEMKEDWQRELEFAFEDMYNADRKVKGNLILHLEPEPLPTVTNQI- 338
+ + + +++ ++ + E + ++ DRK + + EPE Q
Sbjct: 1468 QLLQEREEQQLHRQERDRKFLEEEQQLRRQER---DRKFREQELRSQEPERKFLEEEQQL 1524
Query: 339 --QDEELDLSMEQENLGAAE---------DLPVTEAEICSSETDVPLVMKTQQIPSKVLF 387
Q + E++ L E D E E E + + + ++ F
Sbjct: 1525 HRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRK---F 1581
Query: 388 KKLLNKIRSQKSLWTIKSMSEDESEMITTVSEIESKAPTVESGTIASKERTLSSGQEQVV 447
+ K+R Q+ + EDE ++ E + + E+ L +EQ +
Sbjct: 1582 RLEEQKVRRQEQE---RKFMEDEQQLRR--QEGQQQLRQERDRKFREDEQLLQEREEQQL 1636
Query: 448 ---ESDTLTIESGP-LASEDKPLSCGTN-------------SGKEQEINETLPITTVAQS 490
E D +E P L +++ + G+EQ++ +
Sbjct: 1637 HRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREE 1696
Query: 491 SVLLHPQEAAARIRMSARQKQIMEIEEQKQKQLELLEQIEQQKLRLETDCFRAQLEEEKR 550
L QE + +Q + E+E + +++ +L ++ EQ++LR + + +R LEEE+
Sbjct: 1697 EQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQ-ERYRKILEEEQL 1755
Query: 551 KKTQPTGVGIAPASCPVISDEDSHRQMIRNYQHQLLQQNRLHRQSVETARKQLLEYQTML 610
+ + +E+ RQ Q + + +R R+ E R++ E Q
Sbjct: 1756 RPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREE-EQLRQEREEQQLRP 1814
Query: 611 KGRCPSVSAPSLITDSVISVPSWKSERPTAISEHWDQGQRLKLSPNK-YQPIQPIQTSKL 669
+ R W+ E+ + +Q QRL+ ++ Y+ + T +
Sbjct: 1815 QQRDGKY--------------RWEEEQ----LQLEEQEQRLRQERDRQYRAEEQFATQEK 1856
Query: 670 EQDHFQVARQNHFPQRQVETTETLRASDILTNQALESQEHLRQFSQTETQQ 720
+ Q Q +R+ E LR I Q E Q H RQ + ++Q+
Sbjct: 1857 SRREEQELWQEEEQKRRQERERKLREEHI-RRQQKEEQRH-RQVGEIKSQE 1905
Score = 32.3 bits (72), Expect = 6.3
Identities = 23/115 (20%), Positives = 57/115 (49%), Gaps = 7/115 (6%)
Query: 2485 KRKKSFMERSHQRQKEIRNK---IHVSENSQIKTVKEKPSISSSVSRLKGVNKVRASFPE 2541
K ++ E QRQ+E++ + + E +++ +E+ RL+ ++R E
Sbjct: 255 KEEEKLQEEEPQRQRELQEEEEQLRKLERQELR--RERQEEEQQQQRLRREQQLRRKQEE 312
Query: 2542 DRKTTQALRHQRGLRLYNQLAEVKQQKEEKTKQEAYAQNRARAKEFHKKTLEKLR 2596
+R+ Q R ++ R Q E +++++ + +QE + + R ++ ++ ++LR
Sbjct: 313 ERREQQEERREQQERREQQ--EERREQQLRREQEERREQQLRREQEEERREQQLR 365
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 73.9 bits (180), Expect = 2e-12
Identities = 305/1563 (19%), Positives = 588/1563 (37%), Gaps = 252/1563 (16%)
Query: 35 LQVREQERDIALQIREDIKQRRNQQFTRLAEELRAEWEESQTQKIQNLEKLYLASLRSMG 94
LQ R ERD+ ++ R ++ +L E +A ++ ++ + L +G
Sbjct: 1163 LQQRHGERDVEVE-------RWRERVAQLLERWQAVLAQTDVRQRE---------LEQLG 1206
Query: 95 EGHRQAKENEPDLDALAQRAAERKRKAD---LRHKEALKVQKNQKEILLKQKTWHIKARK 151
R +E+ L A Q A R+ + L +A++ Q Q++ LL++ H + +
Sbjct: 1207 RQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVE 1266
Query: 152 EALLVEKERSAKITSLPPPPPTLFENIEVKRISAVKTNSST--------YHHLHTFVNRE 203
E K+ I T +E A K + Y L T +
Sbjct: 1267 ECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSEL 1326
Query: 204 TDTKRPDARLAAE-----EEAKRLEELQKQAAQERMERFEKAHVRGFQAMKKIHLAQNQ- 257
T + +E EE +RL E Q+ +ER+ E A + Q + A+ Q
Sbjct: 1327 TTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQA 1386
Query: 258 EKLMKELKQLQQEDLARRRQTVAQMPPQLVELPYKRSEMKEDWQRELEFAFEDMYNADR- 316
E+ KEL+Q QE++ RR + Q + + ++++ + E++ A+R
Sbjct: 1387 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS 1446
Query: 317 --KVKGNL-ILHLEPEPLPTVTNQIQDEELDLSMEQENLGAAEDLPVTEAEICSSETDVP 373
+++ + ++ L+ E + E L E A + EAE +
Sbjct: 1447 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1506
Query: 374 LVMKTQ---QIPSKVL--FKKLLNKIRSQKSLWTIKSMSED------------------- 409
K Q ++ S+V + K R+ ++L ++ +E+
Sbjct: 1507 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1566
Query: 410 -ESEMITTVSEIESKAPTVESGTIASKERTLSSGQEQVVESDTLTIESGPLASEDKPLSC 468
E+ + +E++SK + T A ER+L QE+ V L E+ A +
Sbjct: 1567 LETAQRSAEAELQSKRASFAEKT-AQLERSL---QEEHVAVAQLREEAERRAQQQAEAER 1622
Query: 469 GTNSGKEQ------EINETLPI----------TTVAQSSVLLHPQEAAARIR-------M 505
+ + + NE L + ++AQ+ +EA R
Sbjct: 1623 AREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQ 1682
Query: 506 SARQKQIMEIEEQKQKQL-------------ELL------EQIEQQKLRLETDCFRAQLE 546
+ RQ+++ E E +KQ+QL EL+ EQ EQQ+ LE + R Q E
Sbjct: 1683 AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1742
Query: 547 ----EEKRKKTQPTGVGIAPASCPVI------SDEDSHRQMIRNYQHQLLQQNRLHRQSV 596
+KR++ + + A V+ ++E+S ++ Q + R +
Sbjct: 1743 AAAATQKRQELE-AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1801
Query: 597 ETARKQLLEYQTMLKGRCPS-------VSAPSLITDSVISV---PSWKSERPTAISEHWD 646
E AR + L + + + A ++ + + ++ K+E A+ E
Sbjct: 1802 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1861
Query: 647 QGQRLKLSPNKYQPIQPIQTSKLEQDHFQVARQNHFPQRQVETTETLRASDI-LTNQALE 705
+ +RL+ + + Q +LE+ Q H + + +ASD L Q
Sbjct: 1862 ENERLR----RLAEDEAFQRRRLEEQAAQ-----HKADIEERLAQLRKASDSELERQKGL 1912
Query: 706 SQEHLRQFSQTETQQRDYKLVPKDSETLSRALSHDRQLISQDARKISETFGATTFQSLES 765
++ LRQ Q E + K + + L + I +A + ++
Sbjct: 1913 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1972
Query: 766 QQLFSENSENISYHLTEPSSFVPLVPQHSFSSLPVKVESGKIQEPFSAMSKSTVSTSHSI 825
+QL +E E V Q S ++ +E + K+ + +
Sbjct: 1973 RQLAAEEER----RRREAEERV----QKSLAA----------EEEAARQRKAALEEVERL 2014
Query: 826 ISQMHDRPLLPSENITAQQGNMKALQEQLDLQKKVLQATQEAQEQLLLCKQKEVEQ--QT 883
+++ + L A+Q + + LQ + +K LQA ++A + K++E++Q Q
Sbjct: 2015 KAKVEEARRLRER---AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2071
Query: 884 GLSVFLPLVTPDSSALLPSAKADLGRIQ-ESSPTKNNIAVSSDHHVISQLQDKRLSLSQP 942
SV L +A + +A+ R+Q E ++ V + +++ + +Q
Sbjct: 2072 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQA 2131
Query: 943 ILSQQNNFKFLQEQLNIQKDSLQARR-EAQEVLYVHKQ---SELDRRVCSEQAEPSFPFQ 998
+ E+L + + ARR +A++ KQ +E+++ + Q
Sbjct: 2132 --------QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQ 2183
Query: 999 VAQHTFT---SLPSADTKSGKIQEQHSSKSEKGLVSCQSDIPISQDGSLSFLQQFLPLHD 1055
V Q T L D + + E+ + + + + ++
Sbjct: 2184 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE------------LF 2231
Query: 1056 SLKLLQEQLTKQRDTLQARHEAQVELLLHRQRDLGD---SKSGLVSSSSSPVVVQHSVAS 1112
S+++ E+L+K L+AR EA+ L+ R +D + + + SVA+
Sbjct: 2232 SVRVQMEELSK----LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2287
Query: 1113 QASAK---------AEPRRIQELYLSEK-ENVGPSCHLIIPTFQDKSLSFPQHSLAQQEN 1162
Q +A+ A+ R + E L EK + V + L + L Q LAQ++
Sbjct: 2288 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL----KAEAELLQQQKELAQEQA 2343
Query: 1163 LTILQEQSQIQRVILGAKEGTQEFVHTESELEKRISSEQTGTSSSLSQV--------DES 1214
+ +++ Q+ + + +G Q + E + + +S+E ++++ +++
Sbjct: 2344 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2403
Query: 1215 ERFQ---ECISIKSDSTIPLSHPKIPRCQ--ERLLRVSQHMLPLQDNLEEHQAWLDTEKE 1269
+RF+ E I K T + K+ Q E + S H + L E A L+ EKE
Sbjct: 2404 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD---AERLREAIAELEREKE 2460
Query: 1270 AFHFSQKTQENTSSE-QTGSSSFIPQLVQLSFTSLASAESGTILEPLFTESESKIFSSHL 1328
K + S E QT + Q Q S S + + F E E
Sbjct: 2461 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK------A 2514
Query: 1329 QIPQL-QDRLLRISQLIQPQQDNLKALQEQLATQREAIILARQEAREELLLHQSEWEGRI 1387
++ QL QD + + QL + QQ Q+Q+ +R+ ++ + +EAR Q E E +
Sbjct: 2515 KLEQLFQDEVAKAQQLREEQQRQ----QQQMEQERQRLVASMEEARR----RQHEAEEGV 2566
Query: 1388 SPEQVDTSSLP---------LVPQHSFASLPLNESERNQEPCSINSDNIVSSGHSEIPTL 1438
+Q + L L ++ L E +S+ + +S + TL
Sbjct: 2567 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTL 2626
Query: 1439 PDG 1441
P+G
Sbjct: 2627 PNG 2629
Score = 73.6 bits (179), Expect = 2e-12
Identities = 238/1240 (19%), Positives = 472/1240 (38%), Gaps = 148/1240 (11%)
Query: 10 KLRLSPNEEAFILKEDYERRRKLRLLQVREQERDIALQIREDIKQRRNQQFTRLAEELRA 69
+LR S E E + RL ++ E+ R + LQ+ +QR + A RA
Sbjct: 1424 QLRQSSEAEIQAKARQAEAAERSRL-RIEEEIRVVRLQLEATERQRGGAEGELQALRARA 1482
Query: 70 EWEESQTQKIQNLEKLYLASLRSMGEGHRQAKENEPDLDALAQRAAERKRKADLRHKEAL 129
E E+Q ++ Q + ++ + RQA E E A+ A R+++ L+ E L
Sbjct: 1483 EEAEAQKRQAQEEAERLRRQVQDESQRKRQA-EVELASRVKAEAEAAREKQRALQALEEL 1541
Query: 130 KVQKNQKEILLKQKTWHIKARKEALLVEKERSAKITSLPPPPPTLFENIEVKRISAVKTN 189
++Q + E L+Q + + L +RSA+ ++ KR S +
Sbjct: 1542 RLQAEEAERRLRQAEVERARQVQVALETAQRSAE------------AELQSKRASFAEKT 1589
Query: 190 SSTYHHLHTFVNRETDTKRPDARLAAEEEAKRLEELQKQAAQERMER-FEKAHVRGFQAM 248
+ L + A+L E E + ++ + + A+E ER E+ ++ +A+
Sbjct: 1590 AQLERSLQ-------EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1642
Query: 249 KKIHLAQNQEKLMKELKQLQQEDLARRRQTVAQMPPQLVELPYKRSEMKE---DWQREL- 304
++ L + K L Q + E + A+ + E ++ E+ E + QR+L
Sbjct: 1643 -RLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLA 1701
Query: 305 EFAFEDMYNADRKVKGNLILHLEPEPLPTVTNQIQDEELDLSMEQENLGAAEDLPVTEAE 364
E + A++++ + L E E Q+ +EEL +++E A + EAE
Sbjct: 1702 EGTAQQRLAAEQEL---IRLRAETEQ-GEQQRQLLEEEL-ARLQREAAAATQKRQELEAE 1756
Query: 365 ICS--SETDVPLVMKTQ-QIPSKVLFKKLLNKIRSQKSLWTIKSMSEDESEMITTVSEIE 421
+ +E +V L K + + S+ +K +K R + + ++E+ + + E +
Sbjct: 1757 LAKVRAEMEVLLASKARAEEESRSTSEK--SKQRLEAEAGRFRELAEEAARLRALAEEAK 1814
Query: 422 SKAPTVESGTI---ASKERTLSSGQEQVVESDTLTIESGPLASEDKPLSCGTNSGKEQEI 478
+ E A ER L+ + E+ L E+ E + + E E
Sbjct: 1815 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1874
Query: 479 NETLPITTVAQSSVLLHPQEAAARIRMSA-----RQKQIME--IEEQKQKQLELL----- 526
+ + A + +E A++R ++ RQK ++E + +++Q + E+L
Sbjct: 1875 FQRRRLEEQA-AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKAS 1933
Query: 527 ---EQIEQQKLRLETDCFRAQLEEEKRKKTQPTGVGIAPASCPVISDEDSHRQMIRNYQH 583
+ +L LE R+ E+ R K Q + A +E R+ Q
Sbjct: 1934 FEKAAAGKAELELELGRIRSNAEDTLRSKEQ-AELEAARQRQLAAEEERRRREAEERVQK 1992
Query: 584 QLLQQNRLHRQSVETAR-----KQLLEYQTMLKGRCPSVSAPSLITDSVISVPSWKSERP 638
L + RQ K +E L+ R SA L + ++E
Sbjct: 1993 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK 2052
Query: 639 TAISEHWDQGQRLKLSPNKYQPI----------QPIQTSKLEQDHFQVARQNHFPQRQVE 688
+ Q L+ + + Q + + E+ Q R+ +RQVE
Sbjct: 2053 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2112
Query: 689 TTETLRASDILTNQALESQEHLRQFSQTETQQRDYKLVPKDSETLSRALSHDRQLISQDA 748
E L+ S QA + + + E +Q + + L + + D ++ +
Sbjct: 2113 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM--EKH 2170
Query: 749 RKISETFGATTFQSLESQQLFSENSENISYHLTEPSSFVPLVPQHSFSSLPVKVESGKIQ 808
+K +E Q+L + + + L E H + L +++ K +
Sbjct: 2171 KKFAE-------QTLRQKAQVEQELTTLRLQLEE--------TDHQKNLLDEELQRLKAE 2215
Query: 809 EPFSAMSKSTVSTS-HSIISQMHD----RPLLPSEN----ITAQQGNMKALQEQLDLQKK 859
+A +S V S+ QM + + + +EN + + + LQE+ + K+
Sbjct: 2216 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2275
Query: 860 VLQ-------ATQEAQEQLLLCKQKEVEQQTGLSVFLPLVTPDSSALLPSAKADLGRIQE 912
V + A QEA +L ++++ QQ L+ + K + +QE
Sbjct: 2276 VAEEAARLSVAAQEA-ARLRQLAEEDLAQQRALAEKM-------------LKEKMQAVQE 2321
Query: 913 SSPTKNNIAVSSDHHVISQLQDKRL-----SLSQPILSQQNNFKFL-----QEQLNIQKD 962
++ K + ++Q Q +RL ++Q + + F+ Q QL + +
Sbjct: 2322 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE 2381
Query: 963 SLQARREAQEVLYVHKQSELDRRVCSEQAEPSFPFQVAQHTFTSLPSADTKSGKIQEQHS 1022
+ + + E+ ++E D + +QAE T ++ +IQ Q S
Sbjct: 2382 AERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2441
Query: 1023 SKSEKGLVSCQSDI-----PISQDGSLSFLQQFLPLHDSLKLLQEQLTKQRDTLQARHEA 1077
+ L +++ + Q+ L L+ + + QEQL ++ LQ +
Sbjct: 2442 DHDAERLREAIAELEREKEKLQQEAKLLQLKS----EEMQTVQQEQLLQETQALQQSFLS 2497
Query: 1078 QVELLLHRQRDLGDSKSGLVSSSSSPVVVQHSVASQASAKAEPRRIQELYLSEKENVGPS 1137
+ + LL R+R + K+ L + Q VA + E +R Q+ E++ + S
Sbjct: 2498 EKDSLLQRERFIEQEKAKLEQ------LFQDEVAKAQQLREEQQRQQQQMEQERQRLVAS 2551
Query: 1138 CHLIIPTFQDKSLSFPQHSLAQQENLTILQEQSQIQRVIL 1177
+ + + + +QE L L++Q + Q +L
Sbjct: 2552 ----MEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2587
Score = 69.7 bits (169), Expect = 4e-11
Identities = 209/1051 (19%), Positives = 404/1051 (38%), Gaps = 170/1051 (16%)
Query: 17 EEAFILKEDYERRRKLRLLQVREQER---DIALQIREDIKQRRNQQFTRLAEE---LRAE 70
E+A + + ER +L + E R + + ++E K+ N++ RLAE+ R
Sbjct: 1822 EDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE--KEAENERLRRLAEDEAFQRRR 1879
Query: 71 WEESQTQKIQNLEKLYLASLRSMGEGH---------------RQAKENEPDLDALAQRAA 115
EE Q ++E+ LA LR + RQ +E L A ++AA
Sbjct: 1880 LEEQAAQHKADIEER-LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA 1938
Query: 116 ERKRKADLRHKEALKVQKNQKEILLKQKTWHIKA-RKEALLVEKERSAKITSLPPPPPTL 174
K + +L E +++ N ++ L ++ ++A R+ L E+ER
Sbjct: 1939 AGKAELEL---ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR------------- 1982
Query: 175 FENIEVKRISAVKTNSSTYHHLHTFVNRETDTKRPDARLAAEEEAKRLEE---------- 224
+R + + S R+ + + A EEA+RL E
Sbjct: 1983 ------RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2036
Query: 225 -LQKQAAQERMERFEKAHVRGFQAMKKIHLAQNQEKLMKELKQLQQE-DLARRRQTVAQM 282
L ++AAQ+R++ EKAH Q K+ L Q ++ L QL+ E + ARR A+
Sbjct: 2037 QLAQEAAQKRLQAEEKAHAFAVQ-QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2095
Query: 283 PPQLVELPYKRSEMKEDWQRELEFAFEDMYNADRKVKGNLILHLEPEPLPTVTNQIQDEE 342
E +S + + L+ + E+ A + + L E + Q E+
Sbjct: 2096 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA-AAEKLRKEAEQEAARRAQAEQ 2154
Query: 343 LDLSMEQ-------ENLGAAEDLPVTEAEICSSETDVPLVMKTQQIPSKVLFKKLLN--- 392
L +Q ++ AE +A++ T + L ++ +L ++L
Sbjct: 2155 AALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKA 2214
Query: 393 ------KIRSQ--KSLWTIKSMSEDESEMITTVSEIESKAPTVESGTIASKERTLSSGQE 444
+ RSQ + L++++ E+ S++ + E E++A + K+ T QE
Sbjct: 2215 EATEAARQRSQVEEELFSVRVQMEELSKLKARI-EAENRAL-----ILRDKDNTQRFLQE 2268
Query: 445 QVVESDTLTIESGPLASEDKPLSCGTNSGKEQEINETLPITTVAQSSVLLHPQEA---AA 501
+ + + E+ L+ ++ + Q E L +L +A A
Sbjct: 2269 EAEKMKQVAEEAARLS-----VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT 2323
Query: 502 RIRMSAR--QKQIMEIEEQKQKQLELLEQIEQQKLRLETDCFRAQLEEEKRKKTQPTG-- 557
R++ A Q+Q +EQ ++ E EQ+ QQ L ET F+ LE E++++ + +
Sbjct: 2324 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ-LAEETQGFQRTLEAERQRQLEMSAEA 2382
Query: 558 ----VGIAPAS-CPVISDEDSHRQMIRNYQHQLLQQNRLHRQSVETARKQLLEYQTMLKG 612
+ +A S ++ED+ R R ++ +LHR + T K L QT+
Sbjct: 2383 ERLKLRVAEMSRAQARAEEDAQR--FRKQAEEI--GEKLHRTELATQEKVTL-VQTLEIQ 2437
Query: 613 RCPSVSAPSLITDSVISVPSWKS--ERPTAISEHWDQGQRLKLSPNKYQPIQPIQTSKLE 670
R S + +++ + K ++ + + + + Q Q +Q S L
Sbjct: 2438 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2497
Query: 671 QDHFQVARQNHFPQRQVETTETLRASDILTNQALESQEHLRQFSQTETQQ-----RDYKL 725
+ + R+ Q + + + + Q E Q+ +Q + E Q+ + +
Sbjct: 2498 EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2557
Query: 726 VPKDSETLSRALSHDRQLISQDARKISETFGATTFQSLESQQLFSE-------NSENISY 778
++E R + Q + Q R+ E + E QL E +SE ++
Sbjct: 2558 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2617
Query: 779 HLTEPSSFVP------------LVPQHSFSSLPVKVESGKIQEP--FSAMSKSTVSTSHS 824
+ +P P+HSF L KV + ++QE SA ++ H+
Sbjct: 2618 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2677
Query: 825 IISQMHDRPLLPSENITAQQGNMKALQEQLDLQKKVLQATQEAQEQLLLCKQKEVEQQTG 884
+ ++ R + LQ + + +L+AT E L +++Q
Sbjct: 2678 TVDELARR-----------EDVRHYLQGRSSIAGLLLKATNEK-----LSVYAALQRQ-- 2719
Query: 885 LSVFLPLVTPDSSALLPSAKADLG---------RIQESSPTKNNIAVSSDHHVISQLQDK 935
L++P ++ +L A+A G R+ + K + HH + +
Sbjct: 2720 ------LLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERA 2773
Query: 936 RLSLSQPILSQQ-NNFKFLQEQLNIQKDSLQ 965
P QQ + F+ +Q+ L +++ ++
Sbjct: 2774 VTGYKDPYTGQQISLFQAMQKGLIVREHGIR 2804
Score = 66.2 bits (160), Expect = 4e-10
Identities = 325/1784 (18%), Positives = 662/1784 (37%), Gaps = 255/1784 (14%)
Query: 50 EDIKQRRNQQFTRLAEELRAEWEESQT----QKIQNLEKLYLASLRSMGEGHRQAKENEP 105
+DI+ + TR LR ++ Q+I +K A + +G+G +
Sbjct: 990 KDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQ-AEVEGLGKGVARLSAEAE 1048
Query: 106 DLDALAQ---RAAERKRKADLRHKEALKVQKNQKEILLKQKTWHIKAR-----KEALLVE 157
+ AL + A + + +L + +V+ L K KT + R +E L
Sbjct: 1049 KVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH 1108
Query: 158 KERSAKITSLPPPPPTLFENIEVKRISAVKTNSSTYHHLHTFVNRETDTKRPDARLAAEE 217
+E+ + ++P P L E + S K + TF D R + R A+E
Sbjct: 1109 EEQLKEAQAVPATLPEL----EATKASLKKLRAQAEAQQPTF-----DALRDELR-GAQE 1158
Query: 218 EAKRLEEL--QKQAAQERM-ERFEKAHVRGFQAMKKIHLAQNQ-EKLMKELKQLQQ---- 269
+RL++ ++ ER ER + R + + + Q + E+L ++L+ ++
Sbjct: 1159 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADP 1218
Query: 270 -----EDLARRRQTVAQMPPQLVELPYKRSEMKEDWQ--RELEFAFEDMYNADRKVKGNL 322
+D RR++ + MP L + R +++++ E+E E + R K
Sbjct: 1219 LGAWLQDARRRQEQIQAMP--LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAK-QY 1275
Query: 323 ILHLEPEPLPTVTNQIQDEELDLSMEQENLGAAEDLPVTEAEICSSETDVPLVMKTQQIP 382
I ++ L VT + Q E + ++ + + + + E + + +Q I
Sbjct: 1276 INAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK 1335
Query: 383 SKVLFKKLLNKIRSQKSLWTIKSMSEDESEMITTVSEIESKAPTVESGTIASKERTLSSG 442
+ L ++ ++ L + +E+ + + +E + E+ A + +
Sbjct: 1336 ---FISETLRRMEEEERL-AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK 1391
Query: 443 ------QEQVVESDTLTIESGPLASEDKPLSCGTNSGKEQEINETLPITTVAQSSVLLHP 496
QE+VV + +++ + E EI A+ S L
Sbjct: 1392 ELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1451
Query: 497 QEA-AARIRMSARQKQIMEIEEQKQKQLELLEQIEQQKLRL--ETDCFRAQLEEEKRKKT 553
+E R+++ A ++Q E + Q E+ E QK + E + R Q+++E ++K
Sbjct: 1452 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR 1511
Query: 554 QPTGVGIAPASCPVISDEDSHRQMIRNYQHQLLQQNRLHRQSVETARKQLLEYQTMLKGR 613
Q A + S + + R Q L L Q+ E R+ L + + R
Sbjct: 1512 Q--------AEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR--LRQAEVERAR 1561
Query: 614 CPSVSAPSLITDSVISVPSWKSERPTAISEHWDQGQRLKLSPNKYQPIQPIQTSKLEQDH 673
V+ + + + S ++ + +E Q +R L+++H
Sbjct: 1562 QVQVALETAQRSAEAELQSKRA----SFAEKTAQLER-----------------SLQEEH 1600
Query: 674 FQVARQNHFPQRQVET-TETLRASDI----LTNQALESQEHLRQFSQTETQQRDYKLVPK 728
VA+ +R+ + E RA + L L++ E LR Q E + L
Sbjct: 1601 VAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQA 1660
Query: 729 DSETLSRALSHDRQLISQDARKISETFGATTFQSLESQQLFSENSENISYHLTEPSSFVP 788
++E ++A + + G Q++ ++L + E L E ++
Sbjct: 1661 EAEKQK-----------EEAEREARRRGKAEEQAVRQRELAEQELEK-QRQLAEGTAQQR 1708
Query: 789 LVPQHSFSSLPVKVESGKIQEPFSAMSKSTVSTSHSIISQMHDRPLLPSENITAQQGNMK 848
L + L + E G+ Q R LL E Q+
Sbjct: 1709 LAAEQELIRLRAETEQGEQQ-----------------------RQLLEEELARLQREAAA 1745
Query: 849 ALQEQLDLQKKVLQATQEAQEQLLLCKQKEVEQQTGLSVFLPLVTPDSSALLPSAKADLG 908
A Q++ +L+ ++ A A+ ++LL + E+++ + S +A+ G
Sbjct: 1746 ATQKRQELEAEL--AKVRAEMEVLLASKARAEEESRST---------SEKSKQRLEAEAG 1794
Query: 909 RIQESSPTKNNIAVSSDHHVISQLQDKRLSLSQPILSQQNNFKFLQEQLNIQKDSLQARR 968
R +E + + ++ + ++L+ + + L E+L ++ + +
Sbjct: 1795 RFRELAEEAARLRALAEE----AKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT 1850
Query: 969 EAQEVLYVHKQSELDR--RVCSEQA--EPSFPFQVAQHTFTSLPSADTKSGKIQEQHSSK 1024
EA E+ K++E +R R+ ++A Q AQH AD + Q + +S
Sbjct: 1851 EA-EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH------KADIEERLAQLRKASD 1903
Query: 1025 SE----KGLV--SCQSDIPISQDGSLSFLQQFLPLHDSLKLLQEQLTKQR----DTLQAR 1074
SE KGLV + + + ++ L+ F L+ +L + R DTL+++
Sbjct: 1904 SELERQKGLVEDTLRQRRQVEEE-ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSK 1962
Query: 1075 HEAQVELLLHRQRDLGDSKSGLVSSSSSPVVVQHSVASQASAKAEPRRIQELYLSEKENV 1134
+A++E RQ + + + VQ S+A++ A + + E K V
Sbjct: 1963 EQAELEAARQRQLAAEEERRRREAEER----VQKSLAAEEEAARQRKAALEEVERLKAKV 2018
Query: 1135 GPSCHLIIPTFQD--KSLSFPQ-------------HSLAQQENLTILQEQSQIQRVILGA 1179
+ L Q+ + L Q H+ A Q+ LQ+ Q ++ +L
Sbjct: 2019 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2078
Query: 1180 KEGTQEFVHTESEL--EKRISSEQTGTSSSLSQVDESERFQECISIKSDSTIPLSHPKIP 1237
G E +E E R+ +E+ S QV+E+ER ++ ++ +
Sbjct: 2079 LRGEAEAARRAAEEAEEARVQAEREAAQSR-RQVEEAERLKQSAEEQAQARAQAQAAAEK 2137
Query: 1238 RCQERLLRVSQHMLPLQDNLEEHQAW-LDTEKEAFHFSQKTQENTSSEQTGSSSFIPQLV 1296
+E ++ Q L + QA + EK Q ++ EQ +L
Sbjct: 2138 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ--------ELT 2189
Query: 1297 QLSFTSLASAESGTILEPLFTESESKIFSSHLQIPQLQDRLLRISQLIQPQQDNLKALQE 1356
L + +L+ +++ + Q Q+++ L + + Q + L L+
Sbjct: 2190 TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV----RVQMEELSKLKA 2245
Query: 1357 QLATQREAIILARQEAREELLLHQSEWEGRISPEQVDTSSLPLVPQHSFASLPLNESERN 1416
++ + A+IL ++ + L ++E +++ E + L + Q + L E +
Sbjct: 2246 RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE---AARLSVAAQEAARLRQLAEEDLA 2302
Query: 1417 QEPCSINSDNIVSSGHSEIPTLPDGLLGLSHLVLPQQDNLIALEEHLHAQTDFLPSIEKT 1476
Q+ L+ +L ++ + L A+ + L +
Sbjct: 2303 QQRA------------------------LAEKMLKEKMQAVQEATRLKAEAELL----QQ 2334
Query: 1477 QKELVLSKPCKFEEKVSSEHFIQSHHGDLQALQQQLDTQKKAIRSIQEVQEELLLQRLSE 1536
QKEL + + +E E Q + Q Q+ L+ +++ + E L L R++E
Sbjct: 2335 QKELAQEQARRLQE--DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL-RVAE 2391
Query: 1537 LEKRVSSEQVCSSSFVSQVPVADSERTQKSFPTKSNDTL--------PSSHREIPRLQDR 1588
+ + + + + F Q + + T+ TL S + RL++
Sbjct: 2392 MSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA 2451
Query: 1589 LLSLSKPILP-QQDNMTAQLDAQREVMYSYEKPQEELSLNKQRKLNKSESAEHTIPSLFL 1647
+ L + QQ+ QL ++ E+ +E +Q L++ +S F+
Sbjct: 2452 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR--ERFI 2509
Query: 1648 PKETEHSFIPLPFAEAKPKSTCELYSSQNEHAAPPSNPVIPGFQD---RLLSFSQSVLTQ 1704
+E AK + E Q + ++ ++ R + V +
Sbjct: 2510 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2569
Query: 1705 QDNLGLQKQLDLQREVLHYSQKAQEKLLVQRQTALQQQIQKHEE 1748
Q+ L +QL+ QR + QE+LL + L++Q+Q EE
Sbjct: 2570 QEEL---QQLEQQR-------RQQEELLAEENQRLREQLQLLEE 2603
Score = 65.5 bits (158), Expect = 7e-10
Identities = 317/1778 (17%), Positives = 637/1778 (35%), Gaps = 269/1778 (15%)
Query: 228 QAAQERMERFEKAHVRGFQAMKKIHLAQNQ----EKLMKELKQLQQEDLARRRQTVAQMP 283
Q AQE + R E H ++H+ + L ++++ ++ LA R +
Sbjct: 863 QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQ 922
Query: 284 PQLV---ELPYKRSEMKEDWQRELEFAFEDMYNADRKVKGNLILHLEPEPLPTVTNQIQD 340
Q + EL Y+ D Q F ED A+R+ G+ H + + L ++ Q+
Sbjct: 923 RQALHSLELHYQA--FLRDSQDAGGFGPEDRLMAEREY-GSCSHHYQ-QLLQSLEQGAQE 978
Query: 341 EELDLSMEQENLGAAEDLPVTEAEICSSETDVPLVMKTQQIPSKVLFKKLLNKIRSQ--- 397
E S Q + +D+ + + E C + T L + + P++ +++ + ++Q
Sbjct: 979 E----SRCQRCISELKDIRL-QLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEV 1033
Query: 398 KSLWTIKSMSEDESEMITTVSEIESKAPTVESG---TIASKERTLSSGQEQVVESDTLTI 454
+ L + E+E + + E APT+ S T+ E+ S + + T+++
Sbjct: 1034 EGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISL 1093
Query: 455 ESGPLASEDKPLSCGTNSGKE-QEINETLPITTVAQSSV--------------------L 493
++ L KE Q + TLP ++S+ L
Sbjct: 1094 VIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDEL 1153
Query: 494 LHPQEAAARIRMSARQKQIMEIEEQKQKQLELLEQIEQQKLRLETDCFRAQLEE------ 547
QE R++ ++ + E+E +++ +LLE+ Q + +TD + +LE+
Sbjct: 1154 RGAQEVGERLQQRHGERDV-EVERWRERVAQLLER--WQAVLAQTDVRQRELEQLGRQLR 1210
Query: 548 EKRKKTQPTGVGIAPA-------SCPVISDEDSHRQMIRNYQHQLLQQNRLHRQSVETAR 600
R+ P G + A ++D + R+ +R Q LL++ H + VE +
Sbjct: 1211 YYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQ-ALLEEIERHGEKVEECQ 1269
Query: 601 KQLLEYQTMLKG---RCPSVSAPSLITDSVISVPSWKSERPTAISEHWD-QGQRLKLSPN 656
+ +Y +K + + A S P +S + I E+ D + +L+
Sbjct: 1270 RFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTL 1329
Query: 657 KYQPIQPI-QTSKLEQDHFQVARQNHFPQRQ--VETTETLRASDILTN-------QALES 706
Q I+ I +T + ++ ++A Q +R+ E L L QA
Sbjct: 1330 TSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAERE 1389
Query: 707 QEHLRQFSQTETQQRDYKLVPKDSETLSRALSHDRQLISQDARKISETFGATTFQSLESQ 766
+ L+Q Q E +R+ V D++ R++ + Q + Q + + A ++ E
Sbjct: 1390 AKELQQRMQEEVVRREEAAV--DAQQQKRSIQEELQQLRQSSEAEIQA-KARQAEAAERS 1446
Query: 767 QLFSENSENISYHLTEPSSFVPLVPQHSFSSLPVKVESGKIQEPFSAMSKSTVSTSHSII 826
+L E + E + + +L + E + Q+ + + +
Sbjct: 1447 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK------RQAQEEAERLR 1500
Query: 827 SQMHDRPLLPSENITAQQGNMKALQEQLDLQKKVLQATQE----AQEQLLLCKQKEVEQQ 882
Q+ D + +KA E +++ LQA +E A+E +Q EVE+
Sbjct: 1501 RQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1560
Query: 883 TGLSVFLPLVTPDSSALLPSAKADLGRIQESSPTKNNIAVSSDHHVISQLQDK------- 935
+ V L + A L S +A + ++ +H ++QL+++
Sbjct: 1561 RQVQVALETAQRSAEAELQSKRASFAE----KTAQLERSLQEEHVAVAQLREEAERRAQQ 1616
Query: 936 --------------------------RLSLSQPILSQQNNFKFLQEQLNIQKDSLQARRE 969
RL L ++QQ + + + ++ +ARR
Sbjct: 1617 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1676
Query: 970 AQEVLYVHKQSELDRRVCSEQ---AEPSFPFQVAQHTFTSLPSADTKSGKIQEQHSSKSE 1026
+ +Q EL + +Q AE + ++A A+T+ G EQ E
Sbjct: 1677 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG---EQQRQLLE 1733
Query: 1027 KGLVSCQSDIPISQDGSLSFLQQFLPLHDSLKLLQEQLTKQRDTLQARHEA---QVELLL 1083
+ L Q + + + + +++L + + ++ E ++E
Sbjct: 1734 EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA 1793
Query: 1084 HRQRDLGDSKSGLVS---------------SSSSPVVVQHSVASQASAKAEPRRIQ---E 1125
R R+L + + L + ++ + +A + +A E R++ E
Sbjct: 1794 GRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE 1853
Query: 1126 LYLSEKENVGPSCHLIIP--TFQDKSLS--FPQHSLAQQENLTILQEQS----------- 1170
+ L EKE + FQ + L QH +E L L++ S
Sbjct: 1854 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV 1913
Query: 1171 --------QIQRVILGAKEGTQEFVHTESELEK---RISSEQTGTSSSLSQVD------- 1212
Q++ IL K ++ ++ELE RI S T S Q +
Sbjct: 1914 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1973
Query: 1213 ------------ESERFQECISIKSDST------------IPLSHPKIPRCQERLLRVSQ 1248
ER Q+ ++ + ++ + + R +ER + S
Sbjct: 1974 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2033
Query: 1249 HMLPLQDNLEEHQAWLDTEKEAFHFSQKTQENTSSEQTGSSSFIPQLVQLSFTSLASAES 1308
L L + + + + AF QK QE + Q S L QL + A+ +
Sbjct: 2034 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV----LDQLRGEAEAARRA 2089
Query: 1309 GTILEPLFTESESKIFSSHLQIPQLQDRLLRISQLIQPQQDNLKALQEQLATQREAIILA 1368
E ++E + S Q+ + + RL + ++ + +A E+L + E
Sbjct: 2090 AEEAEEARVQAEREAAQSRRQVEEAE-RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2148
Query: 1369 RQEAREELLLHQSEWEGRISPEQVDTSSLPLVPQHSFASLPLNESERNQEPCSINSDNIV 1428
R +A + L Q + + FA L + + ++ + +
Sbjct: 2149 RAQAEQAAL------------RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2196
Query: 1429 SSGHS------EIPTLPDGLLGLSHLVLPQQDNLIALEEHLHAQTDFLPSIEKTQKELVL 1482
+ H E+ L + ++ L ++ + + IE + L+L
Sbjct: 2197 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2256
Query: 1483 SKPCKFEEKVSSEHFIQSHHGDLQALQQQLDTQKKAIRSIQEVQEELLLQRLSELEKRVS 1542
+K +++ F+Q + ++ ++A R QE L++L+E + ++
Sbjct: 2257 ------RDKDNTQRFLQ------EEAEKMKQVAEEAARLSVAAQEAARLRQLAEED--LA 2302
Query: 1543 SEQVCSSSFVSQVPVADSERTQKSFPTKSNDTLPSSHREIPRLQDRLLSLSKPILPQQ-- 1600
++ + + + A E T+ K+ L +E+ + Q R L K + QQ
Sbjct: 2303 QQRALAEKMLKEKMQAVQEATR----LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2358
Query: 1601 ---DNMTAQLDAQREVMYSYEKPQEELSLNKQRKLNKSESAEHTIPSLFLPKETEHSFIP 1657
L+A+R+ E L L AE K+ E
Sbjct: 2359 EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF--RKQAEEIGEK 2416
Query: 1658 LPFAEAKPKS------TCELYSSQNEHAAPPSNPVIPGFQDRLLSFSQS-----VLTQQD 1706
L E + T E+ Q++H A I + Q + +++
Sbjct: 2417 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2476
Query: 1707 NLGLQKQLDLQREVLHYSQKAQEKLLVQRQTALQQQIQKHEETLKDFFKDSQISKPTVEN 1766
Q+QL + + L S +++ L+QR+ ++Q+ K E+ +D +Q + E
Sbjct: 2477 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE--EQ 2534
Query: 1767 DLKTQKMGQLRDWFPNTQDLAGNDQENIRHADRNNSDD 1804
+ Q+M Q R + + A Q R ++
Sbjct: 2535 QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE 2572
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 73.9 bits (180), Expect = 2e-12
Identities = 305/1563 (19%), Positives = 588/1563 (37%), Gaps = 252/1563 (16%)
Query: 35 LQVREQERDIALQIREDIKQRRNQQFTRLAEELRAEWEESQTQKIQNLEKLYLASLRSMG 94
LQ R ERD+ ++ R ++ +L E +A ++ ++ + L +G
Sbjct: 1167 LQQRHGERDVEVE-------RWRERVAQLLERWQAVLAQTDVRQRE---------LEQLG 1210
Query: 95 EGHRQAKENEPDLDALAQRAAERKRKAD---LRHKEALKVQKNQKEILLKQKTWHIKARK 151
R +E+ L A Q A R+ + L +A++ Q Q++ LL++ H + +
Sbjct: 1211 RQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVE 1270
Query: 152 EALLVEKERSAKITSLPPPPPTLFENIEVKRISAVKTNSST--------YHHLHTFVNRE 203
E K+ I T +E A K + Y L T +
Sbjct: 1271 ECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSEL 1330
Query: 204 TDTKRPDARLAAE-----EEAKRLEELQKQAAQERMERFEKAHVRGFQAMKKIHLAQNQ- 257
T + +E EE +RL E Q+ +ER+ E A + Q + A+ Q
Sbjct: 1331 TTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQA 1390
Query: 258 EKLMKELKQLQQEDLARRRQTVAQMPPQLVELPYKRSEMKEDWQRELEFAFEDMYNADR- 316
E+ KEL+Q QE++ RR + Q + + ++++ + E++ A+R
Sbjct: 1391 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS 1450
Query: 317 --KVKGNL-ILHLEPEPLPTVTNQIQDEELDLSMEQENLGAAEDLPVTEAEICSSETDVP 373
+++ + ++ L+ E + E L E A + EAE +
Sbjct: 1451 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1510
Query: 374 LVMKTQ---QIPSKVL--FKKLLNKIRSQKSLWTIKSMSED------------------- 409
K Q ++ S+V + K R+ ++L ++ +E+
Sbjct: 1511 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1570
Query: 410 -ESEMITTVSEIESKAPTVESGTIASKERTLSSGQEQVVESDTLTIESGPLASEDKPLSC 468
E+ + +E++SK + T A ER+L QE+ V L E+ A +
Sbjct: 1571 LETAQRSAEAELQSKRASFAEKT-AQLERSL---QEEHVAVAQLREEAERRAQQQAEAER 1626
Query: 469 GTNSGKEQ------EINETLPI----------TTVAQSSVLLHPQEAAARIR-------M 505
+ + + NE L + ++AQ+ +EA R
Sbjct: 1627 AREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQ 1686
Query: 506 SARQKQIMEIEEQKQKQL-------------ELL------EQIEQQKLRLETDCFRAQLE 546
+ RQ+++ E E +KQ+QL EL+ EQ EQQ+ LE + R Q E
Sbjct: 1687 AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1746
Query: 547 ----EEKRKKTQPTGVGIAPASCPVI------SDEDSHRQMIRNYQHQLLQQNRLHRQSV 596
+KR++ + + A V+ ++E+S ++ Q + R +
Sbjct: 1747 AAAATQKRQELE-AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1805
Query: 597 ETARKQLLEYQTMLKGRCPS-------VSAPSLITDSVISV---PSWKSERPTAISEHWD 646
E AR + L + + + A ++ + + ++ K+E A+ E
Sbjct: 1806 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1865
Query: 647 QGQRLKLSPNKYQPIQPIQTSKLEQDHFQVARQNHFPQRQVETTETLRASDI-LTNQALE 705
+ +RL+ + + Q +LE+ Q H + + +ASD L Q
Sbjct: 1866 ENERLR----RLAEDEAFQRRRLEEQAAQ-----HKADIEERLAQLRKASDSELERQKGL 1916
Query: 706 SQEHLRQFSQTETQQRDYKLVPKDSETLSRALSHDRQLISQDARKISETFGATTFQSLES 765
++ LRQ Q E + K + + L + I +A + ++
Sbjct: 1917 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1976
Query: 766 QQLFSENSENISYHLTEPSSFVPLVPQHSFSSLPVKVESGKIQEPFSAMSKSTVSTSHSI 825
+QL +E E V Q S ++ +E + K+ + +
Sbjct: 1977 RQLAAEEER----RRREAEERV----QKSLAA----------EEEAARQRKAALEEVERL 2018
Query: 826 ISQMHDRPLLPSENITAQQGNMKALQEQLDLQKKVLQATQEAQEQLLLCKQKEVEQ--QT 883
+++ + L A+Q + + LQ + +K LQA ++A + K++E++Q Q
Sbjct: 2019 KAKVEEARRLRER---AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2075
Query: 884 GLSVFLPLVTPDSSALLPSAKADLGRIQ-ESSPTKNNIAVSSDHHVISQLQDKRLSLSQP 942
SV L +A + +A+ R+Q E ++ V + +++ + +Q
Sbjct: 2076 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQA 2135
Query: 943 ILSQQNNFKFLQEQLNIQKDSLQARR-EAQEVLYVHKQ---SELDRRVCSEQAEPSFPFQ 998
+ E+L + + ARR +A++ KQ +E+++ + Q
Sbjct: 2136 --------QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQ 2187
Query: 999 VAQHTFT---SLPSADTKSGKIQEQHSSKSEKGLVSCQSDIPISQDGSLSFLQQFLPLHD 1055
V Q T L D + + E+ + + + + ++
Sbjct: 2188 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE------------LF 2235
Query: 1056 SLKLLQEQLTKQRDTLQARHEAQVELLLHRQRDLGD---SKSGLVSSSSSPVVVQHSVAS 1112
S+++ E+L+K L+AR EA+ L+ R +D + + + SVA+
Sbjct: 2236 SVRVQMEELSK----LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2291
Query: 1113 QASAK---------AEPRRIQELYLSEK-ENVGPSCHLIIPTFQDKSLSFPQHSLAQQEN 1162
Q +A+ A+ R + E L EK + V + L + L Q LAQ++
Sbjct: 2292 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL----KAEAELLQQQKELAQEQA 2347
Query: 1163 LTILQEQSQIQRVILGAKEGTQEFVHTESELEKRISSEQTGTSSSLSQV--------DES 1214
+ +++ Q+ + + +G Q + E + + +S+E ++++ +++
Sbjct: 2348 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2407
Query: 1215 ERFQ---ECISIKSDSTIPLSHPKIPRCQ--ERLLRVSQHMLPLQDNLEEHQAWLDTEKE 1269
+RF+ E I K T + K+ Q E + S H + L E A L+ EKE
Sbjct: 2408 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD---AERLREAIAELEREKE 2464
Query: 1270 AFHFSQKTQENTSSE-QTGSSSFIPQLVQLSFTSLASAESGTILEPLFTESESKIFSSHL 1328
K + S E QT + Q Q S S + + F E E
Sbjct: 2465 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK------A 2518
Query: 1329 QIPQL-QDRLLRISQLIQPQQDNLKALQEQLATQREAIILARQEAREELLLHQSEWEGRI 1387
++ QL QD + + QL + QQ Q+Q+ +R+ ++ + +EAR Q E E +
Sbjct: 2519 KLEQLFQDEVAKAQQLREEQQRQ----QQQMEQERQRLVASMEEARR----RQHEAEEGV 2570
Query: 1388 SPEQVDTSSLP---------LVPQHSFASLPLNESERNQEPCSINSDNIVSSGHSEIPTL 1438
+Q + L L ++ L E +S+ + +S + TL
Sbjct: 2571 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTL 2630
Query: 1439 PDG 1441
P+G
Sbjct: 2631 PNG 2633
Score = 73.6 bits (179), Expect = 2e-12
Identities = 238/1240 (19%), Positives = 472/1240 (38%), Gaps = 148/1240 (11%)
Query: 10 KLRLSPNEEAFILKEDYERRRKLRLLQVREQERDIALQIREDIKQRRNQQFTRLAEELRA 69
+LR S E E + RL ++ E+ R + LQ+ +QR + A RA
Sbjct: 1428 QLRQSSEAEIQAKARQAEAAERSRL-RIEEEIRVVRLQLEATERQRGGAEGELQALRARA 1486
Query: 70 EWEESQTQKIQNLEKLYLASLRSMGEGHRQAKENEPDLDALAQRAAERKRKADLRHKEAL 129
E E+Q ++ Q + ++ + RQA E E A+ A R+++ L+ E L
Sbjct: 1487 EEAEAQKRQAQEEAERLRRQVQDESQRKRQA-EVELASRVKAEAEAAREKQRALQALEEL 1545
Query: 130 KVQKNQKEILLKQKTWHIKARKEALLVEKERSAKITSLPPPPPTLFENIEVKRISAVKTN 189
++Q + E L+Q + + L +RSA+ ++ KR S +
Sbjct: 1546 RLQAEEAERRLRQAEVERARQVQVALETAQRSAE------------AELQSKRASFAEKT 1593
Query: 190 SSTYHHLHTFVNRETDTKRPDARLAAEEEAKRLEELQKQAAQERMER-FEKAHVRGFQAM 248
+ L + A+L E E + ++ + + A+E ER E+ ++ +A+
Sbjct: 1594 AQLERSLQ-------EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1646
Query: 249 KKIHLAQNQEKLMKELKQLQQEDLARRRQTVAQMPPQLVELPYKRSEMKE---DWQREL- 304
++ L + K L Q + E + A+ + E ++ E+ E + QR+L
Sbjct: 1647 -RLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLA 1705
Query: 305 EFAFEDMYNADRKVKGNLILHLEPEPLPTVTNQIQDEELDLSMEQENLGAAEDLPVTEAE 364
E + A++++ + L E E Q+ +EEL +++E A + EAE
Sbjct: 1706 EGTAQQRLAAEQEL---IRLRAETEQ-GEQQRQLLEEEL-ARLQREAAAATQKRQELEAE 1760
Query: 365 ICS--SETDVPLVMKTQ-QIPSKVLFKKLLNKIRSQKSLWTIKSMSEDESEMITTVSEIE 421
+ +E +V L K + + S+ +K +K R + + ++E+ + + E +
Sbjct: 1761 LAKVRAEMEVLLASKARAEEESRSTSEK--SKQRLEAEAGRFRELAEEAARLRALAEEAK 1818
Query: 422 SKAPTVESGTI---ASKERTLSSGQEQVVESDTLTIESGPLASEDKPLSCGTNSGKEQEI 478
+ E A ER L+ + E+ L E+ E + + E E
Sbjct: 1819 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1878
Query: 479 NETLPITTVAQSSVLLHPQEAAARIRMSA-----RQKQIME--IEEQKQKQLELL----- 526
+ + A + +E A++R ++ RQK ++E + +++Q + E+L
Sbjct: 1879 FQRRRLEEQA-AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKAS 1937
Query: 527 ---EQIEQQKLRLETDCFRAQLEEEKRKKTQPTGVGIAPASCPVISDEDSHRQMIRNYQH 583
+ +L LE R+ E+ R K Q + A +E R+ Q
Sbjct: 1938 FEKAAAGKAELELELGRIRSNAEDTLRSKEQ-AELEAARQRQLAAEEERRRREAEERVQK 1996
Query: 584 QLLQQNRLHRQSVETAR-----KQLLEYQTMLKGRCPSVSAPSLITDSVISVPSWKSERP 638
L + RQ K +E L+ R SA L + ++E
Sbjct: 1997 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK 2056
Query: 639 TAISEHWDQGQRLKLSPNKYQPI----------QPIQTSKLEQDHFQVARQNHFPQRQVE 688
+ Q L+ + + Q + + E+ Q R+ +RQVE
Sbjct: 2057 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2116
Query: 689 TTETLRASDILTNQALESQEHLRQFSQTETQQRDYKLVPKDSETLSRALSHDRQLISQDA 748
E L+ S QA + + + E +Q + + L + + D ++ +
Sbjct: 2117 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM--EKH 2174
Query: 749 RKISETFGATTFQSLESQQLFSENSENISYHLTEPSSFVPLVPQHSFSSLPVKVESGKIQ 808
+K +E Q+L + + + L E H + L +++ K +
Sbjct: 2175 KKFAE-------QTLRQKAQVEQELTTLRLQLEE--------TDHQKNLLDEELQRLKAE 2219
Query: 809 EPFSAMSKSTVSTS-HSIISQMHD----RPLLPSEN----ITAQQGNMKALQEQLDLQKK 859
+A +S V S+ QM + + + +EN + + + LQE+ + K+
Sbjct: 2220 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2279
Query: 860 VLQ-------ATQEAQEQLLLCKQKEVEQQTGLSVFLPLVTPDSSALLPSAKADLGRIQE 912
V + A QEA +L ++++ QQ L+ + K + +QE
Sbjct: 2280 VAEEAARLSVAAQEA-ARLRQLAEEDLAQQRALAEKM-------------LKEKMQAVQE 2325
Query: 913 SSPTKNNIAVSSDHHVISQLQDKRL-----SLSQPILSQQNNFKFL-----QEQLNIQKD 962
++ K + ++Q Q +RL ++Q + + F+ Q QL + +
Sbjct: 2326 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE 2385
Query: 963 SLQARREAQEVLYVHKQSELDRRVCSEQAEPSFPFQVAQHTFTSLPSADTKSGKIQEQHS 1022
+ + + E+ ++E D + +QAE T ++ +IQ Q S
Sbjct: 2386 AERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2445
Query: 1023 SKSEKGLVSCQSDI-----PISQDGSLSFLQQFLPLHDSLKLLQEQLTKQRDTLQARHEA 1077
+ L +++ + Q+ L L+ + + QEQL ++ LQ +
Sbjct: 2446 DHDAERLREAIAELEREKEKLQQEAKLLQLKS----EEMQTVQQEQLLQETQALQQSFLS 2501
Query: 1078 QVELLLHRQRDLGDSKSGLVSSSSSPVVVQHSVASQASAKAEPRRIQELYLSEKENVGPS 1137
+ + LL R+R + K+ L + Q VA + E +R Q+ E++ + S
Sbjct: 2502 EKDSLLQRERFIEQEKAKLEQ------LFQDEVAKAQQLREEQQRQQQQMEQERQRLVAS 2555
Query: 1138 CHLIIPTFQDKSLSFPQHSLAQQENLTILQEQSQIQRVIL 1177
+ + + + +QE L L++Q + Q +L
Sbjct: 2556 ----MEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2591
Score = 69.7 bits (169), Expect = 4e-11
Identities = 209/1051 (19%), Positives = 404/1051 (38%), Gaps = 170/1051 (16%)
Query: 17 EEAFILKEDYERRRKLRLLQVREQER---DIALQIREDIKQRRNQQFTRLAEE---LRAE 70
E+A + + ER +L + E R + + ++E K+ N++ RLAE+ R
Sbjct: 1826 EDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE--KEAENERLRRLAEDEAFQRRR 1883
Query: 71 WEESQTQKIQNLEKLYLASLRSMGEGH---------------RQAKENEPDLDALAQRAA 115
EE Q ++E+ LA LR + RQ +E L A ++AA
Sbjct: 1884 LEEQAAQHKADIEER-LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA 1942
Query: 116 ERKRKADLRHKEALKVQKNQKEILLKQKTWHIKA-RKEALLVEKERSAKITSLPPPPPTL 174
K + +L E +++ N ++ L ++ ++A R+ L E+ER
Sbjct: 1943 AGKAELEL---ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR------------- 1986
Query: 175 FENIEVKRISAVKTNSSTYHHLHTFVNRETDTKRPDARLAAEEEAKRLEE---------- 224
+R + + S R+ + + A EEA+RL E
Sbjct: 1987 ------RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2040
Query: 225 -LQKQAAQERMERFEKAHVRGFQAMKKIHLAQNQEKLMKELKQLQQE-DLARRRQTVAQM 282
L ++AAQ+R++ EKAH Q K+ L Q ++ L QL+ E + ARR A+
Sbjct: 2041 QLAQEAAQKRLQAEEKAHAFAVQ-QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2099
Query: 283 PPQLVELPYKRSEMKEDWQRELEFAFEDMYNADRKVKGNLILHLEPEPLPTVTNQIQDEE 342
E +S + + L+ + E+ A + + L E + Q E+
Sbjct: 2100 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA-AAEKLRKEAEQEAARRAQAEQ 2158
Query: 343 LDLSMEQ-------ENLGAAEDLPVTEAEICSSETDVPLVMKTQQIPSKVLFKKLLN--- 392
L +Q ++ AE +A++ T + L ++ +L ++L
Sbjct: 2159 AALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKA 2218
Query: 393 ------KIRSQ--KSLWTIKSMSEDESEMITTVSEIESKAPTVESGTIASKERTLSSGQE 444
+ RSQ + L++++ E+ S++ + E E++A + K+ T QE
Sbjct: 2219 EATEAARQRSQVEEELFSVRVQMEELSKLKARI-EAENRAL-----ILRDKDNTQRFLQE 2272
Query: 445 QVVESDTLTIESGPLASEDKPLSCGTNSGKEQEINETLPITTVAQSSVLLHPQEA---AA 501
+ + + E+ L+ ++ + Q E L +L +A A
Sbjct: 2273 EAEKMKQVAEEAARLS-----VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT 2327
Query: 502 RIRMSAR--QKQIMEIEEQKQKQLELLEQIEQQKLRLETDCFRAQLEEEKRKKTQPTG-- 557
R++ A Q+Q +EQ ++ E EQ+ QQ L ET F+ LE E++++ + +
Sbjct: 2328 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ-LAEETQGFQRTLEAERQRQLEMSAEA 2386
Query: 558 ----VGIAPAS-CPVISDEDSHRQMIRNYQHQLLQQNRLHRQSVETARKQLLEYQTMLKG 612
+ +A S ++ED+ R R ++ +LHR + T K L QT+
Sbjct: 2387 ERLKLRVAEMSRAQARAEEDAQR--FRKQAEEI--GEKLHRTELATQEKVTL-VQTLEIQ 2441
Query: 613 RCPSVSAPSLITDSVISVPSWKS--ERPTAISEHWDQGQRLKLSPNKYQPIQPIQTSKLE 670
R S + +++ + K ++ + + + + Q Q +Q S L
Sbjct: 2442 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2501
Query: 671 QDHFQVARQNHFPQRQVETTETLRASDILTNQALESQEHLRQFSQTETQQ-----RDYKL 725
+ + R+ Q + + + + Q E Q+ +Q + E Q+ + +
Sbjct: 2502 EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2561
Query: 726 VPKDSETLSRALSHDRQLISQDARKISETFGATTFQSLESQQLFSE-------NSENISY 778
++E R + Q + Q R+ E + E QL E +SE ++
Sbjct: 2562 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2621
Query: 779 HLTEPSSFVP------------LVPQHSFSSLPVKVESGKIQEP--FSAMSKSTVSTSHS 824
+ +P P+HSF L KV + ++QE SA ++ H+
Sbjct: 2622 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2681
Query: 825 IISQMHDRPLLPSENITAQQGNMKALQEQLDLQKKVLQATQEAQEQLLLCKQKEVEQQTG 884
+ ++ R + LQ + + +L+AT E L +++Q
Sbjct: 2682 TVDELARR-----------EDVRHYLQGRSSIAGLLLKATNEK-----LSVYAALQRQ-- 2723
Query: 885 LSVFLPLVTPDSSALLPSAKADLG---------RIQESSPTKNNIAVSSDHHVISQLQDK 935
L++P ++ +L A+A G R+ + K + HH + +
Sbjct: 2724 ------LLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERA 2777
Query: 936 RLSLSQPILSQQ-NNFKFLQEQLNIQKDSLQ 965
P QQ + F+ +Q+ L +++ ++
Sbjct: 2778 VTGYKDPYTGQQISLFQAMQKGLIVREHGIR 2808
Score = 66.2 bits (160), Expect = 4e-10
Identities = 325/1784 (18%), Positives = 662/1784 (37%), Gaps = 255/1784 (14%)
Query: 50 EDIKQRRNQQFTRLAEELRAEWEESQT----QKIQNLEKLYLASLRSMGEGHRQAKENEP 105
+DI+ + TR LR ++ Q+I +K A + +G+G +
Sbjct: 994 KDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQ-AEVEGLGKGVARLSAEAE 1052
Query: 106 DLDALAQ---RAAERKRKADLRHKEALKVQKNQKEILLKQKTWHIKAR-----KEALLVE 157
+ AL + A + + +L + +V+ L K KT + R +E L
Sbjct: 1053 KVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH 1112
Query: 158 KERSAKITSLPPPPPTLFENIEVKRISAVKTNSSTYHHLHTFVNRETDTKRPDARLAAEE 217
+E+ + ++P P L E + S K + TF D R + R A+E
Sbjct: 1113 EEQLKEAQAVPATLPEL----EATKASLKKLRAQAEAQQPTF-----DALRDELR-GAQE 1162
Query: 218 EAKRLEEL--QKQAAQERM-ERFEKAHVRGFQAMKKIHLAQNQ-EKLMKELKQLQQ---- 269
+RL++ ++ ER ER + R + + + Q + E+L ++L+ ++
Sbjct: 1163 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADP 1222
Query: 270 -----EDLARRRQTVAQMPPQLVELPYKRSEMKEDWQ--RELEFAFEDMYNADRKVKGNL 322
+D RR++ + MP L + R +++++ E+E E + R K
Sbjct: 1223 LGAWLQDARRRQEQIQAMP--LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAK-QY 1279
Query: 323 ILHLEPEPLPTVTNQIQDEELDLSMEQENLGAAEDLPVTEAEICSSETDVPLVMKTQQIP 382
I ++ L VT + Q E + ++ + + + + E + + +Q I
Sbjct: 1280 INAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK 1339
Query: 383 SKVLFKKLLNKIRSQKSLWTIKSMSEDESEMITTVSEIESKAPTVESGTIASKERTLSSG 442
+ L ++ ++ L + +E+ + + +E + E+ A + +
Sbjct: 1340 ---FISETLRRMEEEERL-AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK 1395
Query: 443 ------QEQVVESDTLTIESGPLASEDKPLSCGTNSGKEQEINETLPITTVAQSSVLLHP 496
QE+VV + +++ + E EI A+ S L
Sbjct: 1396 ELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1455
Query: 497 QEA-AARIRMSARQKQIMEIEEQKQKQLELLEQIEQQKLRL--ETDCFRAQLEEEKRKKT 553
+E R+++ A ++Q E + Q E+ E QK + E + R Q+++E ++K
Sbjct: 1456 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR 1515
Query: 554 QPTGVGIAPASCPVISDEDSHRQMIRNYQHQLLQQNRLHRQSVETARKQLLEYQTMLKGR 613
Q A + S + + R Q L L Q+ E R+ L + + R
Sbjct: 1516 Q--------AEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR--LRQAEVERAR 1565
Query: 614 CPSVSAPSLITDSVISVPSWKSERPTAISEHWDQGQRLKLSPNKYQPIQPIQTSKLEQDH 673
V+ + + + S ++ + +E Q +R L+++H
Sbjct: 1566 QVQVALETAQRSAEAELQSKRA----SFAEKTAQLER-----------------SLQEEH 1604
Query: 674 FQVARQNHFPQRQVET-TETLRASDI----LTNQALESQEHLRQFSQTETQQRDYKLVPK 728
VA+ +R+ + E RA + L L++ E LR Q E + L
Sbjct: 1605 VAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQA 1664
Query: 729 DSETLSRALSHDRQLISQDARKISETFGATTFQSLESQQLFSENSENISYHLTEPSSFVP 788
++E ++A + + G Q++ ++L + E L E ++
Sbjct: 1665 EAEKQK-----------EEAEREARRRGKAEEQAVRQRELAEQELEK-QRQLAEGTAQQR 1712
Query: 789 LVPQHSFSSLPVKVESGKIQEPFSAMSKSTVSTSHSIISQMHDRPLLPSENITAQQGNMK 848
L + L + E G+ Q R LL E Q+
Sbjct: 1713 LAAEQELIRLRAETEQGEQQ-----------------------RQLLEEELARLQREAAA 1749
Query: 849 ALQEQLDLQKKVLQATQEAQEQLLLCKQKEVEQQTGLSVFLPLVTPDSSALLPSAKADLG 908
A Q++ +L+ ++ A A+ ++LL + E+++ + S +A+ G
Sbjct: 1750 ATQKRQELEAEL--AKVRAEMEVLLASKARAEEESRST---------SEKSKQRLEAEAG 1798
Query: 909 RIQESSPTKNNIAVSSDHHVISQLQDKRLSLSQPILSQQNNFKFLQEQLNIQKDSLQARR 968
R +E + + ++ + ++L+ + + L E+L ++ + +
Sbjct: 1799 RFRELAEEAARLRALAEE----AKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT 1854
Query: 969 EAQEVLYVHKQSELDR--RVCSEQA--EPSFPFQVAQHTFTSLPSADTKSGKIQEQHSSK 1024
EA E+ K++E +R R+ ++A Q AQH AD + Q + +S
Sbjct: 1855 EA-EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH------KADIEERLAQLRKASD 1907
Query: 1025 SE----KGLV--SCQSDIPISQDGSLSFLQQFLPLHDSLKLLQEQLTKQR----DTLQAR 1074
SE KGLV + + + ++ L+ F L+ +L + R DTL+++
Sbjct: 1908 SELERQKGLVEDTLRQRRQVEEE-ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSK 1966
Query: 1075 HEAQVELLLHRQRDLGDSKSGLVSSSSSPVVVQHSVASQASAKAEPRRIQELYLSEKENV 1134
+A++E RQ + + + VQ S+A++ A + + E K V
Sbjct: 1967 EQAELEAARQRQLAAEEERRRREAEER----VQKSLAAEEEAARQRKAALEEVERLKAKV 2022
Query: 1135 GPSCHLIIPTFQD--KSLSFPQ-------------HSLAQQENLTILQEQSQIQRVILGA 1179
+ L Q+ + L Q H+ A Q+ LQ+ Q ++ +L
Sbjct: 2023 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2082
Query: 1180 KEGTQEFVHTESEL--EKRISSEQTGTSSSLSQVDESERFQECISIKSDSTIPLSHPKIP 1237
G E +E E R+ +E+ S QV+E+ER ++ ++ +
Sbjct: 2083 LRGEAEAARRAAEEAEEARVQAEREAAQSR-RQVEEAERLKQSAEEQAQARAQAQAAAEK 2141
Query: 1238 RCQERLLRVSQHMLPLQDNLEEHQAW-LDTEKEAFHFSQKTQENTSSEQTGSSSFIPQLV 1296
+E ++ Q L + QA + EK Q ++ EQ +L
Sbjct: 2142 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ--------ELT 2193
Query: 1297 QLSFTSLASAESGTILEPLFTESESKIFSSHLQIPQLQDRLLRISQLIQPQQDNLKALQE 1356
L + +L+ +++ + Q Q+++ L + + Q + L L+
Sbjct: 2194 TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV----RVQMEELSKLKA 2249
Query: 1357 QLATQREAIILARQEAREELLLHQSEWEGRISPEQVDTSSLPLVPQHSFASLPLNESERN 1416
++ + A+IL ++ + L ++E +++ E + L + Q + L E +
Sbjct: 2250 RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE---AARLSVAAQEAARLRQLAEEDLA 2306
Query: 1417 QEPCSINSDNIVSSGHSEIPTLPDGLLGLSHLVLPQQDNLIALEEHLHAQTDFLPSIEKT 1476
Q+ L+ +L ++ + L A+ + L +
Sbjct: 2307 QQRA------------------------LAEKMLKEKMQAVQEATRLKAEAELL----QQ 2338
Query: 1477 QKELVLSKPCKFEEKVSSEHFIQSHHGDLQALQQQLDTQKKAIRSIQEVQEELLLQRLSE 1536
QKEL + + +E E Q + Q Q+ L+ +++ + E L L R++E
Sbjct: 2339 QKELAQEQARRLQE--DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL-RVAE 2395
Query: 1537 LEKRVSSEQVCSSSFVSQVPVADSERTQKSFPTKSNDTL--------PSSHREIPRLQDR 1588
+ + + + + F Q + + T+ TL S + RL++
Sbjct: 2396 MSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA 2455
Query: 1589 LLSLSKPILP-QQDNMTAQLDAQREVMYSYEKPQEELSLNKQRKLNKSESAEHTIPSLFL 1647
+ L + QQ+ QL ++ E+ +E +Q L++ +S F+
Sbjct: 2456 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR--ERFI 2513
Query: 1648 PKETEHSFIPLPFAEAKPKSTCELYSSQNEHAAPPSNPVIPGFQD---RLLSFSQSVLTQ 1704
+E AK + E Q + ++ ++ R + V +
Sbjct: 2514 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2573
Query: 1705 QDNLGLQKQLDLQREVLHYSQKAQEKLLVQRQTALQQQIQKHEE 1748
Q+ L +QL+ QR + QE+LL + L++Q+Q EE
Sbjct: 2574 QEEL---QQLEQQR-------RQQEELLAEENQRLREQLQLLEE 2607
Score = 65.5 bits (158), Expect = 7e-10
Identities = 317/1778 (17%), Positives = 637/1778 (35%), Gaps = 269/1778 (15%)
Query: 228 QAAQERMERFEKAHVRGFQAMKKIHLAQNQ----EKLMKELKQLQQEDLARRRQTVAQMP 283
Q AQE + R E H ++H+ + L ++++ ++ LA R +
Sbjct: 867 QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQ 926
Query: 284 PQLV---ELPYKRSEMKEDWQRELEFAFEDMYNADRKVKGNLILHLEPEPLPTVTNQIQD 340
Q + EL Y+ D Q F ED A+R+ G+ H + + L ++ Q+
Sbjct: 927 RQALHSLELHYQA--FLRDSQDAGGFGPEDRLMAEREY-GSCSHHYQ-QLLQSLEQGAQE 982
Query: 341 EELDLSMEQENLGAAEDLPVTEAEICSSETDVPLVMKTQQIPSKVLFKKLLNKIRSQ--- 397
E S Q + +D+ + + E C + T L + + P++ +++ + ++Q
Sbjct: 983 E----SRCQRCISELKDIRL-QLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEV 1037
Query: 398 KSLWTIKSMSEDESEMITTVSEIESKAPTVESG---TIASKERTLSSGQEQVVESDTLTI 454
+ L + E+E + + E APT+ S T+ E+ S + + T+++
Sbjct: 1038 EGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISL 1097
Query: 455 ESGPLASEDKPLSCGTNSGKE-QEINETLPITTVAQSSV--------------------L 493
++ L KE Q + TLP ++S+ L
Sbjct: 1098 VIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDEL 1157
Query: 494 LHPQEAAARIRMSARQKQIMEIEEQKQKQLELLEQIEQQKLRLETDCFRAQLEE------ 547
QE R++ ++ + E+E +++ +LLE+ Q + +TD + +LE+
Sbjct: 1158 RGAQEVGERLQQRHGERDV-EVERWRERVAQLLER--WQAVLAQTDVRQRELEQLGRQLR 1214
Query: 548 EKRKKTQPTGVGIAPA-------SCPVISDEDSHRQMIRNYQHQLLQQNRLHRQSVETAR 600
R+ P G + A ++D + R+ +R Q LL++ H + VE +
Sbjct: 1215 YYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQ-ALLEEIERHGEKVEECQ 1273
Query: 601 KQLLEYQTMLKG---RCPSVSAPSLITDSVISVPSWKSERPTAISEHWD-QGQRLKLSPN 656
+ +Y +K + + A S P +S + I E+ D + +L+
Sbjct: 1274 RFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTL 1333
Query: 657 KYQPIQPI-QTSKLEQDHFQVARQNHFPQRQ--VETTETLRASDILTN-------QALES 706
Q I+ I +T + ++ ++A Q +R+ E L L QA
Sbjct: 1334 TSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAERE 1393
Query: 707 QEHLRQFSQTETQQRDYKLVPKDSETLSRALSHDRQLISQDARKISETFGATTFQSLESQ 766
+ L+Q Q E +R+ V D++ R++ + Q + Q + + A ++ E
Sbjct: 1394 AKELQQRMQEEVVRREEAAV--DAQQQKRSIQEELQQLRQSSEAEIQA-KARQAEAAERS 1450
Query: 767 QLFSENSENISYHLTEPSSFVPLVPQHSFSSLPVKVESGKIQEPFSAMSKSTVSTSHSII 826
+L E + E + + +L + E + Q+ + + +
Sbjct: 1451 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK------RQAQEEAERLR 1504
Query: 827 SQMHDRPLLPSENITAQQGNMKALQEQLDLQKKVLQATQE----AQEQLLLCKQKEVEQQ 882
Q+ D + +KA E +++ LQA +E A+E +Q EVE+
Sbjct: 1505 RQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1564
Query: 883 TGLSVFLPLVTPDSSALLPSAKADLGRIQESSPTKNNIAVSSDHHVISQLQDK------- 935
+ V L + A L S +A + ++ +H ++QL+++
Sbjct: 1565 RQVQVALETAQRSAEAELQSKRASFAE----KTAQLERSLQEEHVAVAQLREEAERRAQQ 1620
Query: 936 --------------------------RLSLSQPILSQQNNFKFLQEQLNIQKDSLQARRE 969
RL L ++QQ + + + ++ +ARR
Sbjct: 1621 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1680
Query: 970 AQEVLYVHKQSELDRRVCSEQ---AEPSFPFQVAQHTFTSLPSADTKSGKIQEQHSSKSE 1026
+ +Q EL + +Q AE + ++A A+T+ G EQ E
Sbjct: 1681 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG---EQQRQLLE 1737
Query: 1027 KGLVSCQSDIPISQDGSLSFLQQFLPLHDSLKLLQEQLTKQRDTLQARHEA---QVELLL 1083
+ L Q + + + + +++L + + ++ E ++E
Sbjct: 1738 EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA 1797
Query: 1084 HRQRDLGDSKSGLVS---------------SSSSPVVVQHSVASQASAKAEPRRIQ---E 1125
R R+L + + L + ++ + +A + +A E R++ E
Sbjct: 1798 GRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE 1857
Query: 1126 LYLSEKENVGPSCHLIIP--TFQDKSLS--FPQHSLAQQENLTILQEQS----------- 1170
+ L EKE + FQ + L QH +E L L++ S
Sbjct: 1858 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV 1917
Query: 1171 --------QIQRVILGAKEGTQEFVHTESELEK---RISSEQTGTSSSLSQVD------- 1212
Q++ IL K ++ ++ELE RI S T S Q +
Sbjct: 1918 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1977
Query: 1213 ------------ESERFQECISIKSDST------------IPLSHPKIPRCQERLLRVSQ 1248
ER Q+ ++ + ++ + + R +ER + S
Sbjct: 1978 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2037
Query: 1249 HMLPLQDNLEEHQAWLDTEKEAFHFSQKTQENTSSEQTGSSSFIPQLVQLSFTSLASAES 1308
L L + + + + AF QK QE + Q S L QL + A+ +
Sbjct: 2038 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV----LDQLRGEAEAARRA 2093
Query: 1309 GTILEPLFTESESKIFSSHLQIPQLQDRLLRISQLIQPQQDNLKALQEQLATQREAIILA 1368
E ++E + S Q+ + + RL + ++ + +A E+L + E
Sbjct: 2094 AEEAEEARVQAEREAAQSRRQVEEAE-RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2152
Query: 1369 RQEAREELLLHQSEWEGRISPEQVDTSSLPLVPQHSFASLPLNESERNQEPCSINSDNIV 1428
R +A + L Q + + FA L + + ++ + +
Sbjct: 2153 RAQAEQAAL------------RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2200
Query: 1429 SSGHS------EIPTLPDGLLGLSHLVLPQQDNLIALEEHLHAQTDFLPSIEKTQKELVL 1482
+ H E+ L + ++ L ++ + + IE + L+L
Sbjct: 2201 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2260
Query: 1483 SKPCKFEEKVSSEHFIQSHHGDLQALQQQLDTQKKAIRSIQEVQEELLLQRLSELEKRVS 1542
+K +++ F+Q + ++ ++A R QE L++L+E + ++
Sbjct: 2261 ------RDKDNTQRFLQ------EEAEKMKQVAEEAARLSVAAQEAARLRQLAEED--LA 2306
Query: 1543 SEQVCSSSFVSQVPVADSERTQKSFPTKSNDTLPSSHREIPRLQDRLLSLSKPILPQQ-- 1600
++ + + + A E T+ K+ L +E+ + Q R L K + QQ
Sbjct: 2307 QQRALAEKMLKEKMQAVQEATR----LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2362
Query: 1601 ---DNMTAQLDAQREVMYSYEKPQEELSLNKQRKLNKSESAEHTIPSLFLPKETEHSFIP 1657
L+A+R+ E L L AE K+ E
Sbjct: 2363 EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF--RKQAEEIGEK 2420
Query: 1658 LPFAEAKPKS------TCELYSSQNEHAAPPSNPVIPGFQDRLLSFSQS-----VLTQQD 1706
L E + T E+ Q++H A I + Q + +++
Sbjct: 2421 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2480
Query: 1707 NLGLQKQLDLQREVLHYSQKAQEKLLVQRQTALQQQIQKHEETLKDFFKDSQISKPTVEN 1766
Q+QL + + L S +++ L+QR+ ++Q+ K E+ +D +Q + E
Sbjct: 2481 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE--EQ 2538
Query: 1767 DLKTQKMGQLRDWFPNTQDLAGNDQENIRHADRNNSDD 1804
+ Q+M Q R + + A Q R ++
Sbjct: 2539 QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE 2576
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 73.9 bits (180), Expect = 2e-12
Identities = 305/1563 (19%), Positives = 588/1563 (37%), Gaps = 252/1563 (16%)
Query: 35 LQVREQERDIALQIREDIKQRRNQQFTRLAEELRAEWEESQTQKIQNLEKLYLASLRSMG 94
LQ R ERD+ ++ R ++ +L E +A ++ ++ + L +G
Sbjct: 1163 LQQRHGERDVEVE-------RWRERVAQLLERWQAVLAQTDVRQRE---------LEQLG 1206
Query: 95 EGHRQAKENEPDLDALAQRAAERKRKAD---LRHKEALKVQKNQKEILLKQKTWHIKARK 151
R +E+ L A Q A R+ + L +A++ Q Q++ LL++ H + +
Sbjct: 1207 RQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVE 1266
Query: 152 EALLVEKERSAKITSLPPPPPTLFENIEVKRISAVKTNSST--------YHHLHTFVNRE 203
E K+ I T +E A K + Y L T +
Sbjct: 1267 ECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSEL 1326
Query: 204 TDTKRPDARLAAE-----EEAKRLEELQKQAAQERMERFEKAHVRGFQAMKKIHLAQNQ- 257
T + +E EE +RL E Q+ +ER+ E A + Q + A+ Q
Sbjct: 1327 TTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQA 1386
Query: 258 EKLMKELKQLQQEDLARRRQTVAQMPPQLVELPYKRSEMKEDWQRELEFAFEDMYNADR- 316
E+ KEL+Q QE++ RR + Q + + ++++ + E++ A+R
Sbjct: 1387 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS 1446
Query: 317 --KVKGNL-ILHLEPEPLPTVTNQIQDEELDLSMEQENLGAAEDLPVTEAEICSSETDVP 373
+++ + ++ L+ E + E L E A + EAE +
Sbjct: 1447 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1506
Query: 374 LVMKTQ---QIPSKVL--FKKLLNKIRSQKSLWTIKSMSED------------------- 409
K Q ++ S+V + K R+ ++L ++ +E+
Sbjct: 1507 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1566
Query: 410 -ESEMITTVSEIESKAPTVESGTIASKERTLSSGQEQVVESDTLTIESGPLASEDKPLSC 468
E+ + +E++SK + T A ER+L QE+ V L E+ A +
Sbjct: 1567 LETAQRSAEAELQSKRASFAEKT-AQLERSL---QEEHVAVAQLREEAERRAQQQAEAER 1622
Query: 469 GTNSGKEQ------EINETLPI----------TTVAQSSVLLHPQEAAARIR-------M 505
+ + + NE L + ++AQ+ +EA R
Sbjct: 1623 AREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQ 1682
Query: 506 SARQKQIMEIEEQKQKQL-------------ELL------EQIEQQKLRLETDCFRAQLE 546
+ RQ+++ E E +KQ+QL EL+ EQ EQQ+ LE + R Q E
Sbjct: 1683 AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1742
Query: 547 ----EEKRKKTQPTGVGIAPASCPVI------SDEDSHRQMIRNYQHQLLQQNRLHRQSV 596
+KR++ + + A V+ ++E+S ++ Q + R +
Sbjct: 1743 AAAATQKRQELE-AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1801
Query: 597 ETARKQLLEYQTMLKGRCPS-------VSAPSLITDSVISV---PSWKSERPTAISEHWD 646
E AR + L + + + A ++ + + ++ K+E A+ E
Sbjct: 1802 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1861
Query: 647 QGQRLKLSPNKYQPIQPIQTSKLEQDHFQVARQNHFPQRQVETTETLRASDI-LTNQALE 705
+ +RL+ + + Q +LE+ Q H + + +ASD L Q
Sbjct: 1862 ENERLR----RLAEDEAFQRRRLEEQAAQ-----HKADIEERLAQLRKASDSELERQKGL 1912
Query: 706 SQEHLRQFSQTETQQRDYKLVPKDSETLSRALSHDRQLISQDARKISETFGATTFQSLES 765
++ LRQ Q E + K + + L + I +A + ++
Sbjct: 1913 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1972
Query: 766 QQLFSENSENISYHLTEPSSFVPLVPQHSFSSLPVKVESGKIQEPFSAMSKSTVSTSHSI 825
+QL +E E V Q S ++ +E + K+ + +
Sbjct: 1973 RQLAAEEER----RRREAEERV----QKSLAA----------EEEAARQRKAALEEVERL 2014
Query: 826 ISQMHDRPLLPSENITAQQGNMKALQEQLDLQKKVLQATQEAQEQLLLCKQKEVEQ--QT 883
+++ + L A+Q + + LQ + +K LQA ++A + K++E++Q Q
Sbjct: 2015 KAKVEEARRLRER---AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2071
Query: 884 GLSVFLPLVTPDSSALLPSAKADLGRIQ-ESSPTKNNIAVSSDHHVISQLQDKRLSLSQP 942
SV L +A + +A+ R+Q E ++ V + +++ + +Q
Sbjct: 2072 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQA 2131
Query: 943 ILSQQNNFKFLQEQLNIQKDSLQARR-EAQEVLYVHKQ---SELDRRVCSEQAEPSFPFQ 998
+ E+L + + ARR +A++ KQ +E+++ + Q
Sbjct: 2132 --------QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQ 2183
Query: 999 VAQHTFT---SLPSADTKSGKIQEQHSSKSEKGLVSCQSDIPISQDGSLSFLQQFLPLHD 1055
V Q T L D + + E+ + + + + ++
Sbjct: 2184 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE------------LF 2231
Query: 1056 SLKLLQEQLTKQRDTLQARHEAQVELLLHRQRDLGD---SKSGLVSSSSSPVVVQHSVAS 1112
S+++ E+L+K L+AR EA+ L+ R +D + + + SVA+
Sbjct: 2232 SVRVQMEELSK----LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2287
Query: 1113 QASAK---------AEPRRIQELYLSEK-ENVGPSCHLIIPTFQDKSLSFPQHSLAQQEN 1162
Q +A+ A+ R + E L EK + V + L + L Q LAQ++
Sbjct: 2288 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL----KAEAELLQQQKELAQEQA 2343
Query: 1163 LTILQEQSQIQRVILGAKEGTQEFVHTESELEKRISSEQTGTSSSLSQV--------DES 1214
+ +++ Q+ + + +G Q + E + + +S+E ++++ +++
Sbjct: 2344 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2403
Query: 1215 ERFQ---ECISIKSDSTIPLSHPKIPRCQ--ERLLRVSQHMLPLQDNLEEHQAWLDTEKE 1269
+RF+ E I K T + K+ Q E + S H + L E A L+ EKE
Sbjct: 2404 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD---AERLREAIAELEREKE 2460
Query: 1270 AFHFSQKTQENTSSE-QTGSSSFIPQLVQLSFTSLASAESGTILEPLFTESESKIFSSHL 1328
K + S E QT + Q Q S S + + F E E
Sbjct: 2461 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK------A 2514
Query: 1329 QIPQL-QDRLLRISQLIQPQQDNLKALQEQLATQREAIILARQEAREELLLHQSEWEGRI 1387
++ QL QD + + QL + QQ Q+Q+ +R+ ++ + +EAR Q E E +
Sbjct: 2515 KLEQLFQDEVAKAQQLREEQQRQ----QQQMEQERQRLVASMEEARR----RQHEAEEGV 2566
Query: 1388 SPEQVDTSSLP---------LVPQHSFASLPLNESERNQEPCSINSDNIVSSGHSEIPTL 1438
+Q + L L ++ L E +S+ + +S + TL
Sbjct: 2567 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTL 2626
Query: 1439 PDG 1441
P+G
Sbjct: 2627 PNG 2629
Score = 73.6 bits (179), Expect = 2e-12
Identities = 238/1240 (19%), Positives = 472/1240 (38%), Gaps = 148/1240 (11%)
Query: 10 KLRLSPNEEAFILKEDYERRRKLRLLQVREQERDIALQIREDIKQRRNQQFTRLAEELRA 69
+LR S E E + RL ++ E+ R + LQ+ +QR + A RA
Sbjct: 1424 QLRQSSEAEIQAKARQAEAAERSRL-RIEEEIRVVRLQLEATERQRGGAEGELQALRARA 1482
Query: 70 EWEESQTQKIQNLEKLYLASLRSMGEGHRQAKENEPDLDALAQRAAERKRKADLRHKEAL 129
E E+Q ++ Q + ++ + RQA E E A+ A R+++ L+ E L
Sbjct: 1483 EEAEAQKRQAQEEAERLRRQVQDESQRKRQA-EVELASRVKAEAEAAREKQRALQALEEL 1541
Query: 130 KVQKNQKEILLKQKTWHIKARKEALLVEKERSAKITSLPPPPPTLFENIEVKRISAVKTN 189
++Q + E L+Q + + L +RSA+ ++ KR S +
Sbjct: 1542 RLQAEEAERRLRQAEVERARQVQVALETAQRSAE------------AELQSKRASFAEKT 1589
Query: 190 SSTYHHLHTFVNRETDTKRPDARLAAEEEAKRLEELQKQAAQERMER-FEKAHVRGFQAM 248
+ L + A+L E E + ++ + + A+E ER E+ ++ +A+
Sbjct: 1590 AQLERSLQ-------EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1642
Query: 249 KKIHLAQNQEKLMKELKQLQQEDLARRRQTVAQMPPQLVELPYKRSEMKE---DWQREL- 304
++ L + K L Q + E + A+ + E ++ E+ E + QR+L
Sbjct: 1643 -RLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLA 1701
Query: 305 EFAFEDMYNADRKVKGNLILHLEPEPLPTVTNQIQDEELDLSMEQENLGAAEDLPVTEAE 364
E + A++++ + L E E Q+ +EEL +++E A + EAE
Sbjct: 1702 EGTAQQRLAAEQEL---IRLRAETEQ-GEQQRQLLEEEL-ARLQREAAAATQKRQELEAE 1756
Query: 365 ICS--SETDVPLVMKTQ-QIPSKVLFKKLLNKIRSQKSLWTIKSMSEDESEMITTVSEIE 421
+ +E +V L K + + S+ +K +K R + + ++E+ + + E +
Sbjct: 1757 LAKVRAEMEVLLASKARAEEESRSTSEK--SKQRLEAEAGRFRELAEEAARLRALAEEAK 1814
Query: 422 SKAPTVESGTI---ASKERTLSSGQEQVVESDTLTIESGPLASEDKPLSCGTNSGKEQEI 478
+ E A ER L+ + E+ L E+ E + + E E
Sbjct: 1815 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1874
Query: 479 NETLPITTVAQSSVLLHPQEAAARIRMSA-----RQKQIME--IEEQKQKQLELL----- 526
+ + A + +E A++R ++ RQK ++E + +++Q + E+L
Sbjct: 1875 FQRRRLEEQA-AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKAS 1933
Query: 527 ---EQIEQQKLRLETDCFRAQLEEEKRKKTQPTGVGIAPASCPVISDEDSHRQMIRNYQH 583
+ +L LE R+ E+ R K Q + A +E R+ Q
Sbjct: 1934 FEKAAAGKAELELELGRIRSNAEDTLRSKEQ-AELEAARQRQLAAEEERRRREAEERVQK 1992
Query: 584 QLLQQNRLHRQSVETAR-----KQLLEYQTMLKGRCPSVSAPSLITDSVISVPSWKSERP 638
L + RQ K +E L+ R SA L + ++E
Sbjct: 1993 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK 2052
Query: 639 TAISEHWDQGQRLKLSPNKYQPI----------QPIQTSKLEQDHFQVARQNHFPQRQVE 688
+ Q L+ + + Q + + E+ Q R+ +RQVE
Sbjct: 2053 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2112
Query: 689 TTETLRASDILTNQALESQEHLRQFSQTETQQRDYKLVPKDSETLSRALSHDRQLISQDA 748
E L+ S QA + + + E +Q + + L + + D ++ +
Sbjct: 2113 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM--EKH 2170
Query: 749 RKISETFGATTFQSLESQQLFSENSENISYHLTEPSSFVPLVPQHSFSSLPVKVESGKIQ 808
+K +E Q+L + + + L E H + L +++ K +
Sbjct: 2171 KKFAE-------QTLRQKAQVEQELTTLRLQLEE--------TDHQKNLLDEELQRLKAE 2215
Query: 809 EPFSAMSKSTVSTS-HSIISQMHD----RPLLPSEN----ITAQQGNMKALQEQLDLQKK 859
+A +S V S+ QM + + + +EN + + + LQE+ + K+
Sbjct: 2216 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2275
Query: 860 VLQ-------ATQEAQEQLLLCKQKEVEQQTGLSVFLPLVTPDSSALLPSAKADLGRIQE 912
V + A QEA +L ++++ QQ L+ + K + +QE
Sbjct: 2276 VAEEAARLSVAAQEA-ARLRQLAEEDLAQQRALAEKM-------------LKEKMQAVQE 2321
Query: 913 SSPTKNNIAVSSDHHVISQLQDKRL-----SLSQPILSQQNNFKFL-----QEQLNIQKD 962
++ K + ++Q Q +RL ++Q + + F+ Q QL + +
Sbjct: 2322 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE 2381
Query: 963 SLQARREAQEVLYVHKQSELDRRVCSEQAEPSFPFQVAQHTFTSLPSADTKSGKIQEQHS 1022
+ + + E+ ++E D + +QAE T ++ +IQ Q S
Sbjct: 2382 AERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2441
Query: 1023 SKSEKGLVSCQSDI-----PISQDGSLSFLQQFLPLHDSLKLLQEQLTKQRDTLQARHEA 1077
+ L +++ + Q+ L L+ + + QEQL ++ LQ +
Sbjct: 2442 DHDAERLREAIAELEREKEKLQQEAKLLQLKS----EEMQTVQQEQLLQETQALQQSFLS 2497
Query: 1078 QVELLLHRQRDLGDSKSGLVSSSSSPVVVQHSVASQASAKAEPRRIQELYLSEKENVGPS 1137
+ + LL R+R + K+ L + Q VA + E +R Q+ E++ + S
Sbjct: 2498 EKDSLLQRERFIEQEKAKLEQ------LFQDEVAKAQQLREEQQRQQQQMEQERQRLVAS 2551
Query: 1138 CHLIIPTFQDKSLSFPQHSLAQQENLTILQEQSQIQRVIL 1177
+ + + + +QE L L++Q + Q +L
Sbjct: 2552 ----MEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2587
Score = 69.7 bits (169), Expect = 4e-11
Identities = 209/1051 (19%), Positives = 404/1051 (38%), Gaps = 170/1051 (16%)
Query: 17 EEAFILKEDYERRRKLRLLQVREQER---DIALQIREDIKQRRNQQFTRLAEE---LRAE 70
E+A + + ER +L + E R + + ++E K+ N++ RLAE+ R
Sbjct: 1822 EDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE--KEAENERLRRLAEDEAFQRRR 1879
Query: 71 WEESQTQKIQNLEKLYLASLRSMGEGH---------------RQAKENEPDLDALAQRAA 115
EE Q ++E+ LA LR + RQ +E L A ++AA
Sbjct: 1880 LEEQAAQHKADIEER-LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA 1938
Query: 116 ERKRKADLRHKEALKVQKNQKEILLKQKTWHIKA-RKEALLVEKERSAKITSLPPPPPTL 174
K + +L E +++ N ++ L ++ ++A R+ L E+ER
Sbjct: 1939 AGKAELEL---ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR------------- 1982
Query: 175 FENIEVKRISAVKTNSSTYHHLHTFVNRETDTKRPDARLAAEEEAKRLEE---------- 224
+R + + S R+ + + A EEA+RL E
Sbjct: 1983 ------RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2036
Query: 225 -LQKQAAQERMERFEKAHVRGFQAMKKIHLAQNQEKLMKELKQLQQE-DLARRRQTVAQM 282
L ++AAQ+R++ EKAH Q K+ L Q ++ L QL+ E + ARR A+
Sbjct: 2037 QLAQEAAQKRLQAEEKAHAFAVQ-QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2095
Query: 283 PPQLVELPYKRSEMKEDWQRELEFAFEDMYNADRKVKGNLILHLEPEPLPTVTNQIQDEE 342
E +S + + L+ + E+ A + + L E + Q E+
Sbjct: 2096 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA-AAEKLRKEAEQEAARRAQAEQ 2154
Query: 343 LDLSMEQ-------ENLGAAEDLPVTEAEICSSETDVPLVMKTQQIPSKVLFKKLLN--- 392
L +Q ++ AE +A++ T + L ++ +L ++L
Sbjct: 2155 AALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKA 2214
Query: 393 ------KIRSQ--KSLWTIKSMSEDESEMITTVSEIESKAPTVESGTIASKERTLSSGQE 444
+ RSQ + L++++ E+ S++ + E E++A + K+ T QE
Sbjct: 2215 EATEAARQRSQVEEELFSVRVQMEELSKLKARI-EAENRAL-----ILRDKDNTQRFLQE 2268
Query: 445 QVVESDTLTIESGPLASEDKPLSCGTNSGKEQEINETLPITTVAQSSVLLHPQEA---AA 501
+ + + E+ L+ ++ + Q E L +L +A A
Sbjct: 2269 EAEKMKQVAEEAARLS-----VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT 2323
Query: 502 RIRMSAR--QKQIMEIEEQKQKQLELLEQIEQQKLRLETDCFRAQLEEEKRKKTQPTG-- 557
R++ A Q+Q +EQ ++ E EQ+ QQ L ET F+ LE E++++ + +
Sbjct: 2324 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ-LAEETQGFQRTLEAERQRQLEMSAEA 2382
Query: 558 ----VGIAPAS-CPVISDEDSHRQMIRNYQHQLLQQNRLHRQSVETARKQLLEYQTMLKG 612
+ +A S ++ED+ R R ++ +LHR + T K L QT+
Sbjct: 2383 ERLKLRVAEMSRAQARAEEDAQR--FRKQAEEI--GEKLHRTELATQEKVTL-VQTLEIQ 2437
Query: 613 RCPSVSAPSLITDSVISVPSWKS--ERPTAISEHWDQGQRLKLSPNKYQPIQPIQTSKLE 670
R S + +++ + K ++ + + + + Q Q +Q S L
Sbjct: 2438 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2497
Query: 671 QDHFQVARQNHFPQRQVETTETLRASDILTNQALESQEHLRQFSQTETQQ-----RDYKL 725
+ + R+ Q + + + + Q E Q+ +Q + E Q+ + +
Sbjct: 2498 EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2557
Query: 726 VPKDSETLSRALSHDRQLISQDARKISETFGATTFQSLESQQLFSE-------NSENISY 778
++E R + Q + Q R+ E + E QL E +SE ++
Sbjct: 2558 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2617
Query: 779 HLTEPSSFVP------------LVPQHSFSSLPVKVESGKIQEP--FSAMSKSTVSTSHS 824
+ +P P+HSF L KV + ++QE SA ++ H+
Sbjct: 2618 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2677
Query: 825 IISQMHDRPLLPSENITAQQGNMKALQEQLDLQKKVLQATQEAQEQLLLCKQKEVEQQTG 884
+ ++ R + LQ + + +L+AT E L +++Q
Sbjct: 2678 TVDELARR-----------EDVRHYLQGRSSIAGLLLKATNEK-----LSVYAALQRQ-- 2719
Query: 885 LSVFLPLVTPDSSALLPSAKADLG---------RIQESSPTKNNIAVSSDHHVISQLQDK 935
L++P ++ +L A+A G R+ + K + HH + +
Sbjct: 2720 ------LLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERA 2773
Query: 936 RLSLSQPILSQQ-NNFKFLQEQLNIQKDSLQ 965
P QQ + F+ +Q+ L +++ ++
Sbjct: 2774 VTGYKDPYTGQQISLFQAMQKGLIVREHGIR 2804
Score = 66.2 bits (160), Expect = 4e-10
Identities = 325/1784 (18%), Positives = 662/1784 (37%), Gaps = 255/1784 (14%)
Query: 50 EDIKQRRNQQFTRLAEELRAEWEESQT----QKIQNLEKLYLASLRSMGEGHRQAKENEP 105
+DI+ + TR LR ++ Q+I +K A + +G+G +
Sbjct: 990 KDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQ-AEVEGLGKGVARLSAEAE 1048
Query: 106 DLDALAQ---RAAERKRKADLRHKEALKVQKNQKEILLKQKTWHIKAR-----KEALLVE 157
+ AL + A + + +L + +V+ L K KT + R +E L
Sbjct: 1049 KVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH 1108
Query: 158 KERSAKITSLPPPPPTLFENIEVKRISAVKTNSSTYHHLHTFVNRETDTKRPDARLAAEE 217
+E+ + ++P P L E + S K + TF D R + R A+E
Sbjct: 1109 EEQLKEAQAVPATLPEL----EATKASLKKLRAQAEAQQPTF-----DALRDELR-GAQE 1158
Query: 218 EAKRLEEL--QKQAAQERM-ERFEKAHVRGFQAMKKIHLAQNQ-EKLMKELKQLQQ---- 269
+RL++ ++ ER ER + R + + + Q + E+L ++L+ ++
Sbjct: 1159 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADP 1218
Query: 270 -----EDLARRRQTVAQMPPQLVELPYKRSEMKEDWQ--RELEFAFEDMYNADRKVKGNL 322
+D RR++ + MP L + R +++++ E+E E + R K
Sbjct: 1219 LGAWLQDARRRQEQIQAMP--LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAK-QY 1275
Query: 323 ILHLEPEPLPTVTNQIQDEELDLSMEQENLGAAEDLPVTEAEICSSETDVPLVMKTQQIP 382
I ++ L VT + Q E + ++ + + + + E + + +Q I
Sbjct: 1276 INAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK 1335
Query: 383 SKVLFKKLLNKIRSQKSLWTIKSMSEDESEMITTVSEIESKAPTVESGTIASKERTLSSG 442
+ L ++ ++ L + +E+ + + +E + E+ A + +
Sbjct: 1336 ---FISETLRRMEEEERL-AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK 1391
Query: 443 ------QEQVVESDTLTIESGPLASEDKPLSCGTNSGKEQEINETLPITTVAQSSVLLHP 496
QE+VV + +++ + E EI A+ S L
Sbjct: 1392 ELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1451
Query: 497 QEA-AARIRMSARQKQIMEIEEQKQKQLELLEQIEQQKLRL--ETDCFRAQLEEEKRKKT 553
+E R+++ A ++Q E + Q E+ E QK + E + R Q+++E ++K
Sbjct: 1452 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR 1511
Query: 554 QPTGVGIAPASCPVISDEDSHRQMIRNYQHQLLQQNRLHRQSVETARKQLLEYQTMLKGR 613
Q A + S + + R Q L L Q+ E R+ L + + R
Sbjct: 1512 Q--------AEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR--LRQAEVERAR 1561
Query: 614 CPSVSAPSLITDSVISVPSWKSERPTAISEHWDQGQRLKLSPNKYQPIQPIQTSKLEQDH 673
V+ + + + S ++ + +E Q +R L+++H
Sbjct: 1562 QVQVALETAQRSAEAELQSKRA----SFAEKTAQLER-----------------SLQEEH 1600
Query: 674 FQVARQNHFPQRQVET-TETLRASDI----LTNQALESQEHLRQFSQTETQQRDYKLVPK 728
VA+ +R+ + E RA + L L++ E LR Q E + L
Sbjct: 1601 VAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQA 1660
Query: 729 DSETLSRALSHDRQLISQDARKISETFGATTFQSLESQQLFSENSENISYHLTEPSSFVP 788
++E ++A + + G Q++ ++L + E L E ++
Sbjct: 1661 EAEKQK-----------EEAEREARRRGKAEEQAVRQRELAEQELEK-QRQLAEGTAQQR 1708
Query: 789 LVPQHSFSSLPVKVESGKIQEPFSAMSKSTVSTSHSIISQMHDRPLLPSENITAQQGNMK 848
L + L + E G+ Q R LL E Q+
Sbjct: 1709 LAAEQELIRLRAETEQGEQQ-----------------------RQLLEEELARLQREAAA 1745
Query: 849 ALQEQLDLQKKVLQATQEAQEQLLLCKQKEVEQQTGLSVFLPLVTPDSSALLPSAKADLG 908
A Q++ +L+ ++ A A+ ++LL + E+++ + S +A+ G
Sbjct: 1746 ATQKRQELEAEL--AKVRAEMEVLLASKARAEEESRST---------SEKSKQRLEAEAG 1794
Query: 909 RIQESSPTKNNIAVSSDHHVISQLQDKRLSLSQPILSQQNNFKFLQEQLNIQKDSLQARR 968
R +E + + ++ + ++L+ + + L E+L ++ + +
Sbjct: 1795 RFRELAEEAARLRALAEE----AKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT 1850
Query: 969 EAQEVLYVHKQSELDR--RVCSEQA--EPSFPFQVAQHTFTSLPSADTKSGKIQEQHSSK 1024
EA E+ K++E +R R+ ++A Q AQH AD + Q + +S
Sbjct: 1851 EA-EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH------KADIEERLAQLRKASD 1903
Query: 1025 SE----KGLV--SCQSDIPISQDGSLSFLQQFLPLHDSLKLLQEQLTKQR----DTLQAR 1074
SE KGLV + + + ++ L+ F L+ +L + R DTL+++
Sbjct: 1904 SELERQKGLVEDTLRQRRQVEEE-ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSK 1962
Query: 1075 HEAQVELLLHRQRDLGDSKSGLVSSSSSPVVVQHSVASQASAKAEPRRIQELYLSEKENV 1134
+A++E RQ + + + VQ S+A++ A + + E K V
Sbjct: 1963 EQAELEAARQRQLAAEEERRRREAEER----VQKSLAAEEEAARQRKAALEEVERLKAKV 2018
Query: 1135 GPSCHLIIPTFQD--KSLSFPQ-------------HSLAQQENLTILQEQSQIQRVILGA 1179
+ L Q+ + L Q H+ A Q+ LQ+ Q ++ +L
Sbjct: 2019 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2078
Query: 1180 KEGTQEFVHTESEL--EKRISSEQTGTSSSLSQVDESERFQECISIKSDSTIPLSHPKIP 1237
G E +E E R+ +E+ S QV+E+ER ++ ++ +
Sbjct: 2079 LRGEAEAARRAAEEAEEARVQAEREAAQSR-RQVEEAERLKQSAEEQAQARAQAQAAAEK 2137
Query: 1238 RCQERLLRVSQHMLPLQDNLEEHQAW-LDTEKEAFHFSQKTQENTSSEQTGSSSFIPQLV 1296
+E ++ Q L + QA + EK Q ++ EQ +L
Sbjct: 2138 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ--------ELT 2189
Query: 1297 QLSFTSLASAESGTILEPLFTESESKIFSSHLQIPQLQDRLLRISQLIQPQQDNLKALQE 1356
L + +L+ +++ + Q Q+++ L + + Q + L L+
Sbjct: 2190 TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV----RVQMEELSKLKA 2245
Query: 1357 QLATQREAIILARQEAREELLLHQSEWEGRISPEQVDTSSLPLVPQHSFASLPLNESERN 1416
++ + A+IL ++ + L ++E +++ E + L + Q + L E +
Sbjct: 2246 RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE---AARLSVAAQEAARLRQLAEEDLA 2302
Query: 1417 QEPCSINSDNIVSSGHSEIPTLPDGLLGLSHLVLPQQDNLIALEEHLHAQTDFLPSIEKT 1476
Q+ L+ +L ++ + L A+ + L +
Sbjct: 2303 QQRA------------------------LAEKMLKEKMQAVQEATRLKAEAELL----QQ 2334
Query: 1477 QKELVLSKPCKFEEKVSSEHFIQSHHGDLQALQQQLDTQKKAIRSIQEVQEELLLQRLSE 1536
QKEL + + +E E Q + Q Q+ L+ +++ + E L L R++E
Sbjct: 2335 QKELAQEQARRLQE--DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL-RVAE 2391
Query: 1537 LEKRVSSEQVCSSSFVSQVPVADSERTQKSFPTKSNDTL--------PSSHREIPRLQDR 1588
+ + + + + F Q + + T+ TL S + RL++
Sbjct: 2392 MSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA 2451
Query: 1589 LLSLSKPILP-QQDNMTAQLDAQREVMYSYEKPQEELSLNKQRKLNKSESAEHTIPSLFL 1647
+ L + QQ+ QL ++ E+ +E +Q L++ +S F+
Sbjct: 2452 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR--ERFI 2509
Query: 1648 PKETEHSFIPLPFAEAKPKSTCELYSSQNEHAAPPSNPVIPGFQD---RLLSFSQSVLTQ 1704
+E AK + E Q + ++ ++ R + V +
Sbjct: 2510 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2569
Query: 1705 QDNLGLQKQLDLQREVLHYSQKAQEKLLVQRQTALQQQIQKHEE 1748
Q+ L +QL+ QR + QE+LL + L++Q+Q EE
Sbjct: 2570 QEEL---QQLEQQR-------RQQEELLAEENQRLREQLQLLEE 2603
Score = 65.5 bits (158), Expect = 7e-10
Identities = 317/1778 (17%), Positives = 637/1778 (35%), Gaps = 269/1778 (15%)
Query: 228 QAAQERMERFEKAHVRGFQAMKKIHLAQNQ----EKLMKELKQLQQEDLARRRQTVAQMP 283
Q AQE + R E H ++H+ + L ++++ ++ LA R +
Sbjct: 863 QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQ 922
Query: 284 PQLV---ELPYKRSEMKEDWQRELEFAFEDMYNADRKVKGNLILHLEPEPLPTVTNQIQD 340
Q + EL Y+ D Q F ED A+R+ G+ H + + L ++ Q+
Sbjct: 923 RQALHSLELHYQA--FLRDSQDAGGFGPEDRLMAEREY-GSCSHHYQ-QLLQSLEQGAQE 978
Query: 341 EELDLSMEQENLGAAEDLPVTEAEICSSETDVPLVMKTQQIPSKVLFKKLLNKIRSQ--- 397
E S Q + +D+ + + E C + T L + + P++ +++ + ++Q
Sbjct: 979 E----SRCQRCISELKDIRL-QLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEV 1033
Query: 398 KSLWTIKSMSEDESEMITTVSEIESKAPTVESG---TIASKERTLSSGQEQVVESDTLTI 454
+ L + E+E + + E APT+ S T+ E+ S + + T+++
Sbjct: 1034 EGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISL 1093
Query: 455 ESGPLASEDKPLSCGTNSGKE-QEINETLPITTVAQSSV--------------------L 493
++ L KE Q + TLP ++S+ L
Sbjct: 1094 VIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDEL 1153
Query: 494 LHPQEAAARIRMSARQKQIMEIEEQKQKQLELLEQIEQQKLRLETDCFRAQLEE------ 547
QE R++ ++ + E+E +++ +LLE+ Q + +TD + +LE+
Sbjct: 1154 RGAQEVGERLQQRHGERDV-EVERWRERVAQLLER--WQAVLAQTDVRQRELEQLGRQLR 1210
Query: 548 EKRKKTQPTGVGIAPA-------SCPVISDEDSHRQMIRNYQHQLLQQNRLHRQSVETAR 600
R+ P G + A ++D + R+ +R Q LL++ H + VE +
Sbjct: 1211 YYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQ-ALLEEIERHGEKVEECQ 1269
Query: 601 KQLLEYQTMLKG---RCPSVSAPSLITDSVISVPSWKSERPTAISEHWD-QGQRLKLSPN 656
+ +Y +K + + A S P +S + I E+ D + +L+
Sbjct: 1270 RFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTL 1329
Query: 657 KYQPIQPI-QTSKLEQDHFQVARQNHFPQRQ--VETTETLRASDILTN-------QALES 706
Q I+ I +T + ++ ++A Q +R+ E L L QA
Sbjct: 1330 TSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAERE 1389
Query: 707 QEHLRQFSQTETQQRDYKLVPKDSETLSRALSHDRQLISQDARKISETFGATTFQSLESQ 766
+ L+Q Q E +R+ V D++ R++ + Q + Q + + A ++ E
Sbjct: 1390 AKELQQRMQEEVVRREEAAV--DAQQQKRSIQEELQQLRQSSEAEIQA-KARQAEAAERS 1446
Query: 767 QLFSENSENISYHLTEPSSFVPLVPQHSFSSLPVKVESGKIQEPFSAMSKSTVSTSHSII 826
+L E + E + + +L + E + Q+ + + +
Sbjct: 1447 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK------RQAQEEAERLR 1500
Query: 827 SQMHDRPLLPSENITAQQGNMKALQEQLDLQKKVLQATQE----AQEQLLLCKQKEVEQQ 882
Q+ D + +KA E +++ LQA +E A+E +Q EVE+
Sbjct: 1501 RQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1560
Query: 883 TGLSVFLPLVTPDSSALLPSAKADLGRIQESSPTKNNIAVSSDHHVISQLQDK------- 935
+ V L + A L S +A + ++ +H ++QL+++
Sbjct: 1561 RQVQVALETAQRSAEAELQSKRASFAE----KTAQLERSLQEEHVAVAQLREEAERRAQQ 1616
Query: 936 --------------------------RLSLSQPILSQQNNFKFLQEQLNIQKDSLQARRE 969
RL L ++QQ + + + ++ +ARR
Sbjct: 1617 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1676
Query: 970 AQEVLYVHKQSELDRRVCSEQ---AEPSFPFQVAQHTFTSLPSADTKSGKIQEQHSSKSE 1026
+ +Q EL + +Q AE + ++A A+T+ G EQ E
Sbjct: 1677 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG---EQQRQLLE 1733
Query: 1027 KGLVSCQSDIPISQDGSLSFLQQFLPLHDSLKLLQEQLTKQRDTLQARHEA---QVELLL 1083
+ L Q + + + + +++L + + ++ E ++E
Sbjct: 1734 EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA 1793
Query: 1084 HRQRDLGDSKSGLVS---------------SSSSPVVVQHSVASQASAKAEPRRIQ---E 1125
R R+L + + L + ++ + +A + +A E R++ E
Sbjct: 1794 GRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE 1853
Query: 1126 LYLSEKENVGPSCHLIIP--TFQDKSLS--FPQHSLAQQENLTILQEQS----------- 1170
+ L EKE + FQ + L QH +E L L++ S
Sbjct: 1854 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV 1913
Query: 1171 --------QIQRVILGAKEGTQEFVHTESELEK---RISSEQTGTSSSLSQVD------- 1212
Q++ IL K ++ ++ELE RI S T S Q +
Sbjct: 1914 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1973
Query: 1213 ------------ESERFQECISIKSDST------------IPLSHPKIPRCQERLLRVSQ 1248
ER Q+ ++ + ++ + + R +ER + S
Sbjct: 1974 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2033
Query: 1249 HMLPLQDNLEEHQAWLDTEKEAFHFSQKTQENTSSEQTGSSSFIPQLVQLSFTSLASAES 1308
L L + + + + AF QK QE + Q S L QL + A+ +
Sbjct: 2034 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV----LDQLRGEAEAARRA 2089
Query: 1309 GTILEPLFTESESKIFSSHLQIPQLQDRLLRISQLIQPQQDNLKALQEQLATQREAIILA 1368
E ++E + S Q+ + + RL + ++ + +A E+L + E
Sbjct: 2090 AEEAEEARVQAEREAAQSRRQVEEAE-RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2148
Query: 1369 RQEAREELLLHQSEWEGRISPEQVDTSSLPLVPQHSFASLPLNESERNQEPCSINSDNIV 1428
R +A + L Q + + FA L + + ++ + +
Sbjct: 2149 RAQAEQAAL------------RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2196
Query: 1429 SSGHS------EIPTLPDGLLGLSHLVLPQQDNLIALEEHLHAQTDFLPSIEKTQKELVL 1482
+ H E+ L + ++ L ++ + + IE + L+L
Sbjct: 2197 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2256
Query: 1483 SKPCKFEEKVSSEHFIQSHHGDLQALQQQLDTQKKAIRSIQEVQEELLLQRLSELEKRVS 1542
+K +++ F+Q + ++ ++A R QE L++L+E + ++
Sbjct: 2257 ------RDKDNTQRFLQ------EEAEKMKQVAEEAARLSVAAQEAARLRQLAEED--LA 2302
Query: 1543 SEQVCSSSFVSQVPVADSERTQKSFPTKSNDTLPSSHREIPRLQDRLLSLSKPILPQQ-- 1600
++ + + + A E T+ K+ L +E+ + Q R L K + QQ
Sbjct: 2303 QQRALAEKMLKEKMQAVQEATR----LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2358
Query: 1601 ---DNMTAQLDAQREVMYSYEKPQEELSLNKQRKLNKSESAEHTIPSLFLPKETEHSFIP 1657
L+A+R+ E L L AE K+ E
Sbjct: 2359 EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF--RKQAEEIGEK 2416
Query: 1658 LPFAEAKPKS------TCELYSSQNEHAAPPSNPVIPGFQDRLLSFSQS-----VLTQQD 1706
L E + T E+ Q++H A I + Q + +++
Sbjct: 2417 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2476
Query: 1707 NLGLQKQLDLQREVLHYSQKAQEKLLVQRQTALQQQIQKHEETLKDFFKDSQISKPTVEN 1766
Q+QL + + L S +++ L+QR+ ++Q+ K E+ +D +Q + E
Sbjct: 2477 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE--EQ 2534
Query: 1767 DLKTQKMGQLRDWFPNTQDLAGNDQENIRHADRNNSDD 1804
+ Q+M Q R + + A Q R ++
Sbjct: 2535 QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE 2572
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 73.9 bits (180), Expect = 2e-12
Identities = 305/1563 (19%), Positives = 588/1563 (37%), Gaps = 252/1563 (16%)
Query: 35 LQVREQERDIALQIREDIKQRRNQQFTRLAEELRAEWEESQTQKIQNLEKLYLASLRSMG 94
LQ R ERD+ ++ R ++ +L E +A ++ ++ + L +G
Sbjct: 1131 LQQRHGERDVEVE-------RWRERVAQLLERWQAVLAQTDVRQRE---------LEQLG 1174
Query: 95 EGHRQAKENEPDLDALAQRAAERKRKAD---LRHKEALKVQKNQKEILLKQKTWHIKARK 151
R +E+ L A Q A R+ + L +A++ Q Q++ LL++ H + +
Sbjct: 1175 RQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVE 1234
Query: 152 EALLVEKERSAKITSLPPPPPTLFENIEVKRISAVKTNSST--------YHHLHTFVNRE 203
E K+ I T +E A K + Y L T +
Sbjct: 1235 ECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSEL 1294
Query: 204 TDTKRPDARLAAE-----EEAKRLEELQKQAAQERMERFEKAHVRGFQAMKKIHLAQNQ- 257
T + +E EE +RL E Q+ +ER+ E A + Q + A+ Q
Sbjct: 1295 TTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQA 1354
Query: 258 EKLMKELKQLQQEDLARRRQTVAQMPPQLVELPYKRSEMKEDWQRELEFAFEDMYNADR- 316
E+ KEL+Q QE++ RR + Q + + ++++ + E++ A+R
Sbjct: 1355 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS 1414
Query: 317 --KVKGNL-ILHLEPEPLPTVTNQIQDEELDLSMEQENLGAAEDLPVTEAEICSSETDVP 373
+++ + ++ L+ E + E L E A + EAE +
Sbjct: 1415 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1474
Query: 374 LVMKTQ---QIPSKVL--FKKLLNKIRSQKSLWTIKSMSED------------------- 409
K Q ++ S+V + K R+ ++L ++ +E+
Sbjct: 1475 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1534
Query: 410 -ESEMITTVSEIESKAPTVESGTIASKERTLSSGQEQVVESDTLTIESGPLASEDKPLSC 468
E+ + +E++SK + T A ER+L QE+ V L E+ A +
Sbjct: 1535 LETAQRSAEAELQSKRASFAEKT-AQLERSL---QEEHVAVAQLREEAERRAQQQAEAER 1590
Query: 469 GTNSGKEQ------EINETLPI----------TTVAQSSVLLHPQEAAARIR-------M 505
+ + + NE L + ++AQ+ +EA R
Sbjct: 1591 AREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQ 1650
Query: 506 SARQKQIMEIEEQKQKQL-------------ELL------EQIEQQKLRLETDCFRAQLE 546
+ RQ+++ E E +KQ+QL EL+ EQ EQQ+ LE + R Q E
Sbjct: 1651 AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1710
Query: 547 ----EEKRKKTQPTGVGIAPASCPVI------SDEDSHRQMIRNYQHQLLQQNRLHRQSV 596
+KR++ + + A V+ ++E+S ++ Q + R +
Sbjct: 1711 AAAATQKRQELE-AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1769
Query: 597 ETARKQLLEYQTMLKGRCPS-------VSAPSLITDSVISV---PSWKSERPTAISEHWD 646
E AR + L + + + A ++ + + ++ K+E A+ E
Sbjct: 1770 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1829
Query: 647 QGQRLKLSPNKYQPIQPIQTSKLEQDHFQVARQNHFPQRQVETTETLRASDI-LTNQALE 705
+ +RL+ + + Q +LE+ Q H + + +ASD L Q
Sbjct: 1830 ENERLR----RLAEDEAFQRRRLEEQAAQ-----HKADIEERLAQLRKASDSELERQKGL 1880
Query: 706 SQEHLRQFSQTETQQRDYKLVPKDSETLSRALSHDRQLISQDARKISETFGATTFQSLES 765
++ LRQ Q E + K + + L + I +A + ++
Sbjct: 1881 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1940
Query: 766 QQLFSENSENISYHLTEPSSFVPLVPQHSFSSLPVKVESGKIQEPFSAMSKSTVSTSHSI 825
+QL +E E V Q S ++ +E + K+ + +
Sbjct: 1941 RQLAAEEER----RRREAEERV----QKSLAA----------EEEAARQRKAALEEVERL 1982
Query: 826 ISQMHDRPLLPSENITAQQGNMKALQEQLDLQKKVLQATQEAQEQLLLCKQKEVEQ--QT 883
+++ + L A+Q + + LQ + +K LQA ++A + K++E++Q Q
Sbjct: 1983 KAKVEEARRLRER---AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2039
Query: 884 GLSVFLPLVTPDSSALLPSAKADLGRIQ-ESSPTKNNIAVSSDHHVISQLQDKRLSLSQP 942
SV L +A + +A+ R+Q E ++ V + +++ + +Q
Sbjct: 2040 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQA 2099
Query: 943 ILSQQNNFKFLQEQLNIQKDSLQARR-EAQEVLYVHKQ---SELDRRVCSEQAEPSFPFQ 998
+ E+L + + ARR +A++ KQ +E+++ + Q
Sbjct: 2100 --------QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQ 2151
Query: 999 VAQHTFT---SLPSADTKSGKIQEQHSSKSEKGLVSCQSDIPISQDGSLSFLQQFLPLHD 1055
V Q T L D + + E+ + + + + ++
Sbjct: 2152 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE------------LF 2199
Query: 1056 SLKLLQEQLTKQRDTLQARHEAQVELLLHRQRDLGD---SKSGLVSSSSSPVVVQHSVAS 1112
S+++ E+L+K L+AR EA+ L+ R +D + + + SVA+
Sbjct: 2200 SVRVQMEELSK----LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2255
Query: 1113 QASAK---------AEPRRIQELYLSEK-ENVGPSCHLIIPTFQDKSLSFPQHSLAQQEN 1162
Q +A+ A+ R + E L EK + V + L + L Q LAQ++
Sbjct: 2256 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL----KAEAELLQQQKELAQEQA 2311
Query: 1163 LTILQEQSQIQRVILGAKEGTQEFVHTESELEKRISSEQTGTSSSLSQV--------DES 1214
+ +++ Q+ + + +G Q + E + + +S+E ++++ +++
Sbjct: 2312 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2371
Query: 1215 ERFQ---ECISIKSDSTIPLSHPKIPRCQ--ERLLRVSQHMLPLQDNLEEHQAWLDTEKE 1269
+RF+ E I K T + K+ Q E + S H + L E A L+ EKE
Sbjct: 2372 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD---AERLREAIAELEREKE 2428
Query: 1270 AFHFSQKTQENTSSE-QTGSSSFIPQLVQLSFTSLASAESGTILEPLFTESESKIFSSHL 1328
K + S E QT + Q Q S S + + F E E
Sbjct: 2429 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK------A 2482
Query: 1329 QIPQL-QDRLLRISQLIQPQQDNLKALQEQLATQREAIILARQEAREELLLHQSEWEGRI 1387
++ QL QD + + QL + QQ Q+Q+ +R+ ++ + +EAR Q E E +
Sbjct: 2483 KLEQLFQDEVAKAQQLREEQQRQ----QQQMEQERQRLVASMEEARR----RQHEAEEGV 2534
Query: 1388 SPEQVDTSSLP---------LVPQHSFASLPLNESERNQEPCSINSDNIVSSGHSEIPTL 1438
+Q + L L ++ L E +S+ + +S + TL
Sbjct: 2535 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTL 2594
Query: 1439 PDG 1441
P+G
Sbjct: 2595 PNG 2597
Score = 73.6 bits (179), Expect = 2e-12
Identities = 238/1240 (19%), Positives = 472/1240 (38%), Gaps = 148/1240 (11%)
Query: 10 KLRLSPNEEAFILKEDYERRRKLRLLQVREQERDIALQIREDIKQRRNQQFTRLAEELRA 69
+LR S E E + RL ++ E+ R + LQ+ +QR + A RA
Sbjct: 1392 QLRQSSEAEIQAKARQAEAAERSRL-RIEEEIRVVRLQLEATERQRGGAEGELQALRARA 1450
Query: 70 EWEESQTQKIQNLEKLYLASLRSMGEGHRQAKENEPDLDALAQRAAERKRKADLRHKEAL 129
E E+Q ++ Q + ++ + RQA E E A+ A R+++ L+ E L
Sbjct: 1451 EEAEAQKRQAQEEAERLRRQVQDESQRKRQA-EVELASRVKAEAEAAREKQRALQALEEL 1509
Query: 130 KVQKNQKEILLKQKTWHIKARKEALLVEKERSAKITSLPPPPPTLFENIEVKRISAVKTN 189
++Q + E L+Q + + L +RSA+ ++ KR S +
Sbjct: 1510 RLQAEEAERRLRQAEVERARQVQVALETAQRSAE------------AELQSKRASFAEKT 1557
Query: 190 SSTYHHLHTFVNRETDTKRPDARLAAEEEAKRLEELQKQAAQERMER-FEKAHVRGFQAM 248
+ L + A+L E E + ++ + + A+E ER E+ ++ +A+
Sbjct: 1558 AQLERSLQ-------EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1610
Query: 249 KKIHLAQNQEKLMKELKQLQQEDLARRRQTVAQMPPQLVELPYKRSEMKE---DWQREL- 304
++ L + K L Q + E + A+ + E ++ E+ E + QR+L
Sbjct: 1611 -RLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLA 1669
Query: 305 EFAFEDMYNADRKVKGNLILHLEPEPLPTVTNQIQDEELDLSMEQENLGAAEDLPVTEAE 364
E + A++++ + L E E Q+ +EEL +++E A + EAE
Sbjct: 1670 EGTAQQRLAAEQEL---IRLRAETEQ-GEQQRQLLEEEL-ARLQREAAAATQKRQELEAE 1724
Query: 365 ICS--SETDVPLVMKTQ-QIPSKVLFKKLLNKIRSQKSLWTIKSMSEDESEMITTVSEIE 421
+ +E +V L K + + S+ +K +K R + + ++E+ + + E +
Sbjct: 1725 LAKVRAEMEVLLASKARAEEESRSTSEK--SKQRLEAEAGRFRELAEEAARLRALAEEAK 1782
Query: 422 SKAPTVESGTI---ASKERTLSSGQEQVVESDTLTIESGPLASEDKPLSCGTNSGKEQEI 478
+ E A ER L+ + E+ L E+ E + + E E
Sbjct: 1783 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1842
Query: 479 NETLPITTVAQSSVLLHPQEAAARIRMSA-----RQKQIME--IEEQKQKQLELL----- 526
+ + A + +E A++R ++ RQK ++E + +++Q + E+L
Sbjct: 1843 FQRRRLEEQA-AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKAS 1901
Query: 527 ---EQIEQQKLRLETDCFRAQLEEEKRKKTQPTGVGIAPASCPVISDEDSHRQMIRNYQH 583
+ +L LE R+ E+ R K Q + A +E R+ Q
Sbjct: 1902 FEKAAAGKAELELELGRIRSNAEDTLRSKEQ-AELEAARQRQLAAEEERRRREAEERVQK 1960
Query: 584 QLLQQNRLHRQSVETAR-----KQLLEYQTMLKGRCPSVSAPSLITDSVISVPSWKSERP 638
L + RQ K +E L+ R SA L + ++E
Sbjct: 1961 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK 2020
Query: 639 TAISEHWDQGQRLKLSPNKYQPI----------QPIQTSKLEQDHFQVARQNHFPQRQVE 688
+ Q L+ + + Q + + E+ Q R+ +RQVE
Sbjct: 2021 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2080
Query: 689 TTETLRASDILTNQALESQEHLRQFSQTETQQRDYKLVPKDSETLSRALSHDRQLISQDA 748
E L+ S QA + + + E +Q + + L + + D ++ +
Sbjct: 2081 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM--EKH 2138
Query: 749 RKISETFGATTFQSLESQQLFSENSENISYHLTEPSSFVPLVPQHSFSSLPVKVESGKIQ 808
+K +E Q+L + + + L E H + L +++ K +
Sbjct: 2139 KKFAE-------QTLRQKAQVEQELTTLRLQLEE--------TDHQKNLLDEELQRLKAE 2183
Query: 809 EPFSAMSKSTVSTS-HSIISQMHD----RPLLPSEN----ITAQQGNMKALQEQLDLQKK 859
+A +S V S+ QM + + + +EN + + + LQE+ + K+
Sbjct: 2184 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2243
Query: 860 VLQ-------ATQEAQEQLLLCKQKEVEQQTGLSVFLPLVTPDSSALLPSAKADLGRIQE 912
V + A QEA +L ++++ QQ L+ + K + +QE
Sbjct: 2244 VAEEAARLSVAAQEA-ARLRQLAEEDLAQQRALAEKM-------------LKEKMQAVQE 2289
Query: 913 SSPTKNNIAVSSDHHVISQLQDKRL-----SLSQPILSQQNNFKFL-----QEQLNIQKD 962
++ K + ++Q Q +RL ++Q + + F+ Q QL + +
Sbjct: 2290 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE 2349
Query: 963 SLQARREAQEVLYVHKQSELDRRVCSEQAEPSFPFQVAQHTFTSLPSADTKSGKIQEQHS 1022
+ + + E+ ++E D + +QAE T ++ +IQ Q S
Sbjct: 2350 AERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2409
Query: 1023 SKSEKGLVSCQSDI-----PISQDGSLSFLQQFLPLHDSLKLLQEQLTKQRDTLQARHEA 1077
+ L +++ + Q+ L L+ + + QEQL ++ LQ +
Sbjct: 2410 DHDAERLREAIAELEREKEKLQQEAKLLQLKS----EEMQTVQQEQLLQETQALQQSFLS 2465
Query: 1078 QVELLLHRQRDLGDSKSGLVSSSSSPVVVQHSVASQASAKAEPRRIQELYLSEKENVGPS 1137
+ + LL R+R + K+ L + Q VA + E +R Q+ E++ + S
Sbjct: 2466 EKDSLLQRERFIEQEKAKLEQ------LFQDEVAKAQQLREEQQRQQQQMEQERQRLVAS 2519
Query: 1138 CHLIIPTFQDKSLSFPQHSLAQQENLTILQEQSQIQRVIL 1177
+ + + + +QE L L++Q + Q +L
Sbjct: 2520 ----MEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2555
Score = 69.7 bits (169), Expect = 4e-11
Identities = 209/1051 (19%), Positives = 404/1051 (38%), Gaps = 170/1051 (16%)
Query: 17 EEAFILKEDYERRRKLRLLQVREQER---DIALQIREDIKQRRNQQFTRLAEE---LRAE 70
E+A + + ER +L + E R + + ++E K+ N++ RLAE+ R
Sbjct: 1790 EDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE--KEAENERLRRLAEDEAFQRRR 1847
Query: 71 WEESQTQKIQNLEKLYLASLRSMGEGH---------------RQAKENEPDLDALAQRAA 115
EE Q ++E+ LA LR + RQ +E L A ++AA
Sbjct: 1848 LEEQAAQHKADIEER-LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA 1906
Query: 116 ERKRKADLRHKEALKVQKNQKEILLKQKTWHIKA-RKEALLVEKERSAKITSLPPPPPTL 174
K + +L E +++ N ++ L ++ ++A R+ L E+ER
Sbjct: 1907 AGKAELEL---ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR------------- 1950
Query: 175 FENIEVKRISAVKTNSSTYHHLHTFVNRETDTKRPDARLAAEEEAKRLEE---------- 224
+R + + S R+ + + A EEA+RL E
Sbjct: 1951 ------RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2004
Query: 225 -LQKQAAQERMERFEKAHVRGFQAMKKIHLAQNQEKLMKELKQLQQE-DLARRRQTVAQM 282
L ++AAQ+R++ EKAH Q K+ L Q ++ L QL+ E + ARR A+
Sbjct: 2005 QLAQEAAQKRLQAEEKAHAFAVQ-QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2063
Query: 283 PPQLVELPYKRSEMKEDWQRELEFAFEDMYNADRKVKGNLILHLEPEPLPTVTNQIQDEE 342
E +S + + L+ + E+ A + + L E + Q E+
Sbjct: 2064 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA-AAEKLRKEAEQEAARRAQAEQ 2122
Query: 343 LDLSMEQ-------ENLGAAEDLPVTEAEICSSETDVPLVMKTQQIPSKVLFKKLLN--- 392
L +Q ++ AE +A++ T + L ++ +L ++L
Sbjct: 2123 AALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKA 2182
Query: 393 ------KIRSQ--KSLWTIKSMSEDESEMITTVSEIESKAPTVESGTIASKERTLSSGQE 444
+ RSQ + L++++ E+ S++ + E E++A + K+ T QE
Sbjct: 2183 EATEAARQRSQVEEELFSVRVQMEELSKLKARI-EAENRAL-----ILRDKDNTQRFLQE 2236
Query: 445 QVVESDTLTIESGPLASEDKPLSCGTNSGKEQEINETLPITTVAQSSVLLHPQEA---AA 501
+ + + E+ L+ ++ + Q E L +L +A A
Sbjct: 2237 EAEKMKQVAEEAARLS-----VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT 2291
Query: 502 RIRMSAR--QKQIMEIEEQKQKQLELLEQIEQQKLRLETDCFRAQLEEEKRKKTQPTG-- 557
R++ A Q+Q +EQ ++ E EQ+ QQ L ET F+ LE E++++ + +
Sbjct: 2292 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ-LAEETQGFQRTLEAERQRQLEMSAEA 2350
Query: 558 ----VGIAPAS-CPVISDEDSHRQMIRNYQHQLLQQNRLHRQSVETARKQLLEYQTMLKG 612
+ +A S ++ED+ R R ++ +LHR + T K L QT+
Sbjct: 2351 ERLKLRVAEMSRAQARAEEDAQR--FRKQAEEI--GEKLHRTELATQEKVTL-VQTLEIQ 2405
Query: 613 RCPSVSAPSLITDSVISVPSWKS--ERPTAISEHWDQGQRLKLSPNKYQPIQPIQTSKLE 670
R S + +++ + K ++ + + + + Q Q +Q S L
Sbjct: 2406 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2465
Query: 671 QDHFQVARQNHFPQRQVETTETLRASDILTNQALESQEHLRQFSQTETQQ-----RDYKL 725
+ + R+ Q + + + + Q E Q+ +Q + E Q+ + +
Sbjct: 2466 EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2525
Query: 726 VPKDSETLSRALSHDRQLISQDARKISETFGATTFQSLESQQLFSE-------NSENISY 778
++E R + Q + Q R+ E + E QL E +SE ++
Sbjct: 2526 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2585
Query: 779 HLTEPSSFVP------------LVPQHSFSSLPVKVESGKIQEP--FSAMSKSTVSTSHS 824
+ +P P+HSF L KV + ++QE SA ++ H+
Sbjct: 2586 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2645
Query: 825 IISQMHDRPLLPSENITAQQGNMKALQEQLDLQKKVLQATQEAQEQLLLCKQKEVEQQTG 884
+ ++ R + LQ + + +L+AT E L +++Q
Sbjct: 2646 TVDELARR-----------EDVRHYLQGRSSIAGLLLKATNEK-----LSVYAALQRQ-- 2687
Query: 885 LSVFLPLVTPDSSALLPSAKADLG---------RIQESSPTKNNIAVSSDHHVISQLQDK 935
L++P ++ +L A+A G R+ + K + HH + +
Sbjct: 2688 ------LLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERA 2741
Query: 936 RLSLSQPILSQQ-NNFKFLQEQLNIQKDSLQ 965
P QQ + F+ +Q+ L +++ ++
Sbjct: 2742 VTGYKDPYTGQQISLFQAMQKGLIVREHGIR 2772
Score = 66.2 bits (160), Expect = 4e-10
Identities = 325/1784 (18%), Positives = 662/1784 (37%), Gaps = 255/1784 (14%)
Query: 50 EDIKQRRNQQFTRLAEELRAEWEESQT----QKIQNLEKLYLASLRSMGEGHRQAKENEP 105
+DI+ + TR LR ++ Q+I +K A + +G+G +
Sbjct: 958 KDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQ-AEVEGLGKGVARLSAEAE 1016
Query: 106 DLDALAQ---RAAERKRKADLRHKEALKVQKNQKEILLKQKTWHIKAR-----KEALLVE 157
+ AL + A + + +L + +V+ L K KT + R +E L
Sbjct: 1017 KVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH 1076
Query: 158 KERSAKITSLPPPPPTLFENIEVKRISAVKTNSSTYHHLHTFVNRETDTKRPDARLAAEE 217
+E+ + ++P P L E + S K + TF D R + R A+E
Sbjct: 1077 EEQLKEAQAVPATLPEL----EATKASLKKLRAQAEAQQPTF-----DALRDELR-GAQE 1126
Query: 218 EAKRLEEL--QKQAAQERM-ERFEKAHVRGFQAMKKIHLAQNQ-EKLMKELKQLQQ---- 269
+RL++ ++ ER ER + R + + + Q + E+L ++L+ ++
Sbjct: 1127 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADP 1186
Query: 270 -----EDLARRRQTVAQMPPQLVELPYKRSEMKEDWQ--RELEFAFEDMYNADRKVKGNL 322
+D RR++ + MP L + R +++++ E+E E + R K
Sbjct: 1187 LGAWLQDARRRQEQIQAMP--LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAK-QY 1243
Query: 323 ILHLEPEPLPTVTNQIQDEELDLSMEQENLGAAEDLPVTEAEICSSETDVPLVMKTQQIP 382
I ++ L VT + Q E + ++ + + + + E + + +Q I
Sbjct: 1244 INAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK 1303
Query: 383 SKVLFKKLLNKIRSQKSLWTIKSMSEDESEMITTVSEIESKAPTVESGTIASKERTLSSG 442
+ L ++ ++ L + +E+ + + +E + E+ A + +
Sbjct: 1304 ---FISETLRRMEEEERL-AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK 1359
Query: 443 ------QEQVVESDTLTIESGPLASEDKPLSCGTNSGKEQEINETLPITTVAQSSVLLHP 496
QE+VV + +++ + E EI A+ S L
Sbjct: 1360 ELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1419
Query: 497 QEA-AARIRMSARQKQIMEIEEQKQKQLELLEQIEQQKLRL--ETDCFRAQLEEEKRKKT 553
+E R+++ A ++Q E + Q E+ E QK + E + R Q+++E ++K
Sbjct: 1420 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR 1479
Query: 554 QPTGVGIAPASCPVISDEDSHRQMIRNYQHQLLQQNRLHRQSVETARKQLLEYQTMLKGR 613
Q A + S + + R Q L L Q+ E R+ L + + R
Sbjct: 1480 Q--------AEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR--LRQAEVERAR 1529
Query: 614 CPSVSAPSLITDSVISVPSWKSERPTAISEHWDQGQRLKLSPNKYQPIQPIQTSKLEQDH 673
V+ + + + S ++ + +E Q +R L+++H
Sbjct: 1530 QVQVALETAQRSAEAELQSKRA----SFAEKTAQLER-----------------SLQEEH 1568
Query: 674 FQVARQNHFPQRQVET-TETLRASDI----LTNQALESQEHLRQFSQTETQQRDYKLVPK 728
VA+ +R+ + E RA + L L++ E LR Q E + L
Sbjct: 1569 VAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQA 1628
Query: 729 DSETLSRALSHDRQLISQDARKISETFGATTFQSLESQQLFSENSENISYHLTEPSSFVP 788
++E ++A + + G Q++ ++L + E L E ++
Sbjct: 1629 EAEKQK-----------EEAEREARRRGKAEEQAVRQRELAEQELEK-QRQLAEGTAQQR 1676
Query: 789 LVPQHSFSSLPVKVESGKIQEPFSAMSKSTVSTSHSIISQMHDRPLLPSENITAQQGNMK 848
L + L + E G+ Q R LL E Q+
Sbjct: 1677 LAAEQELIRLRAETEQGEQQ-----------------------RQLLEEELARLQREAAA 1713
Query: 849 ALQEQLDLQKKVLQATQEAQEQLLLCKQKEVEQQTGLSVFLPLVTPDSSALLPSAKADLG 908
A Q++ +L+ ++ A A+ ++LL + E+++ + S +A+ G
Sbjct: 1714 ATQKRQELEAEL--AKVRAEMEVLLASKARAEEESRST---------SEKSKQRLEAEAG 1762
Query: 909 RIQESSPTKNNIAVSSDHHVISQLQDKRLSLSQPILSQQNNFKFLQEQLNIQKDSLQARR 968
R +E + + ++ + ++L+ + + L E+L ++ + +
Sbjct: 1763 RFRELAEEAARLRALAEE----AKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT 1818
Query: 969 EAQEVLYVHKQSELDR--RVCSEQA--EPSFPFQVAQHTFTSLPSADTKSGKIQEQHSSK 1024
EA E+ K++E +R R+ ++A Q AQH AD + Q + +S
Sbjct: 1819 EA-EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH------KADIEERLAQLRKASD 1871
Query: 1025 SE----KGLV--SCQSDIPISQDGSLSFLQQFLPLHDSLKLLQEQLTKQR----DTLQAR 1074
SE KGLV + + + ++ L+ F L+ +L + R DTL+++
Sbjct: 1872 SELERQKGLVEDTLRQRRQVEEE-ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSK 1930
Query: 1075 HEAQVELLLHRQRDLGDSKSGLVSSSSSPVVVQHSVASQASAKAEPRRIQELYLSEKENV 1134
+A++E RQ + + + VQ S+A++ A + + E K V
Sbjct: 1931 EQAELEAARQRQLAAEEERRRREAEER----VQKSLAAEEEAARQRKAALEEVERLKAKV 1986
Query: 1135 GPSCHLIIPTFQD--KSLSFPQ-------------HSLAQQENLTILQEQSQIQRVILGA 1179
+ L Q+ + L Q H+ A Q+ LQ+ Q ++ +L
Sbjct: 1987 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2046
Query: 1180 KEGTQEFVHTESEL--EKRISSEQTGTSSSLSQVDESERFQECISIKSDSTIPLSHPKIP 1237
G E +E E R+ +E+ S QV+E+ER ++ ++ +
Sbjct: 2047 LRGEAEAARRAAEEAEEARVQAEREAAQSR-RQVEEAERLKQSAEEQAQARAQAQAAAEK 2105
Query: 1238 RCQERLLRVSQHMLPLQDNLEEHQAW-LDTEKEAFHFSQKTQENTSSEQTGSSSFIPQLV 1296
+E ++ Q L + QA + EK Q ++ EQ +L
Sbjct: 2106 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ--------ELT 2157
Query: 1297 QLSFTSLASAESGTILEPLFTESESKIFSSHLQIPQLQDRLLRISQLIQPQQDNLKALQE 1356
L + +L+ +++ + Q Q+++ L + + Q + L L+
Sbjct: 2158 TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV----RVQMEELSKLKA 2213
Query: 1357 QLATQREAIILARQEAREELLLHQSEWEGRISPEQVDTSSLPLVPQHSFASLPLNESERN 1416
++ + A+IL ++ + L ++E +++ E + L + Q + L E +
Sbjct: 2214 RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE---AARLSVAAQEAARLRQLAEEDLA 2270
Query: 1417 QEPCSINSDNIVSSGHSEIPTLPDGLLGLSHLVLPQQDNLIALEEHLHAQTDFLPSIEKT 1476
Q+ L+ +L ++ + L A+ + L +
Sbjct: 2271 QQRA------------------------LAEKMLKEKMQAVQEATRLKAEAELL----QQ 2302
Query: 1477 QKELVLSKPCKFEEKVSSEHFIQSHHGDLQALQQQLDTQKKAIRSIQEVQEELLLQRLSE 1536
QKEL + + +E E Q + Q Q+ L+ +++ + E L L R++E
Sbjct: 2303 QKELAQEQARRLQE--DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL-RVAE 2359
Query: 1537 LEKRVSSEQVCSSSFVSQVPVADSERTQKSFPTKSNDTL--------PSSHREIPRLQDR 1588
+ + + + + F Q + + T+ TL S + RL++
Sbjct: 2360 MSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA 2419
Query: 1589 LLSLSKPILP-QQDNMTAQLDAQREVMYSYEKPQEELSLNKQRKLNKSESAEHTIPSLFL 1647
+ L + QQ+ QL ++ E+ +E +Q L++ +S F+
Sbjct: 2420 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR--ERFI 2477
Query: 1648 PKETEHSFIPLPFAEAKPKSTCELYSSQNEHAAPPSNPVIPGFQD---RLLSFSQSVLTQ 1704
+E AK + E Q + ++ ++ R + V +
Sbjct: 2478 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2537
Query: 1705 QDNLGLQKQLDLQREVLHYSQKAQEKLLVQRQTALQQQIQKHEE 1748
Q+ L +QL+ QR + QE+LL + L++Q+Q EE
Sbjct: 2538 QEEL---QQLEQQR-------RQQEELLAEENQRLREQLQLLEE 2571
Score = 65.5 bits (158), Expect = 7e-10
Identities = 317/1778 (17%), Positives = 637/1778 (35%), Gaps = 269/1778 (15%)
Query: 228 QAAQERMERFEKAHVRGFQAMKKIHLAQNQ----EKLMKELKQLQQEDLARRRQTVAQMP 283
Q AQE + R E H ++H+ + L ++++ ++ LA R +
Sbjct: 831 QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQ 890
Query: 284 PQLV---ELPYKRSEMKEDWQRELEFAFEDMYNADRKVKGNLILHLEPEPLPTVTNQIQD 340
Q + EL Y+ D Q F ED A+R+ G+ H + + L ++ Q+
Sbjct: 891 RQALHSLELHYQA--FLRDSQDAGGFGPEDRLMAEREY-GSCSHHYQ-QLLQSLEQGAQE 946
Query: 341 EELDLSMEQENLGAAEDLPVTEAEICSSETDVPLVMKTQQIPSKVLFKKLLNKIRSQ--- 397
E S Q + +D+ + + E C + T L + + P++ +++ + ++Q
Sbjct: 947 E----SRCQRCISELKDIRL-QLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEV 1001
Query: 398 KSLWTIKSMSEDESEMITTVSEIESKAPTVESG---TIASKERTLSSGQEQVVESDTLTI 454
+ L + E+E + + E APT+ S T+ E+ S + + T+++
Sbjct: 1002 EGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISL 1061
Query: 455 ESGPLASEDKPLSCGTNSGKE-QEINETLPITTVAQSSV--------------------L 493
++ L KE Q + TLP ++S+ L
Sbjct: 1062 VIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDEL 1121
Query: 494 LHPQEAAARIRMSARQKQIMEIEEQKQKQLELLEQIEQQKLRLETDCFRAQLEE------ 547
QE R++ ++ + E+E +++ +LLE+ Q + +TD + +LE+
Sbjct: 1122 RGAQEVGERLQQRHGERDV-EVERWRERVAQLLER--WQAVLAQTDVRQRELEQLGRQLR 1178
Query: 548 EKRKKTQPTGVGIAPA-------SCPVISDEDSHRQMIRNYQHQLLQQNRLHRQSVETAR 600
R+ P G + A ++D + R+ +R Q LL++ H + VE +
Sbjct: 1179 YYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQ-ALLEEIERHGEKVEECQ 1237
Query: 601 KQLLEYQTMLKG---RCPSVSAPSLITDSVISVPSWKSERPTAISEHWD-QGQRLKLSPN 656
+ +Y +K + + A S P +S + I E+ D + +L+
Sbjct: 1238 RFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTL 1297
Query: 657 KYQPIQPI-QTSKLEQDHFQVARQNHFPQRQ--VETTETLRASDILTN-------QALES 706
Q I+ I +T + ++ ++A Q +R+ E L L QA
Sbjct: 1298 TSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAERE 1357
Query: 707 QEHLRQFSQTETQQRDYKLVPKDSETLSRALSHDRQLISQDARKISETFGATTFQSLESQ 766
+ L+Q Q E +R+ V D++ R++ + Q + Q + + A ++ E
Sbjct: 1358 AKELQQRMQEEVVRREEAAV--DAQQQKRSIQEELQQLRQSSEAEIQA-KARQAEAAERS 1414
Query: 767 QLFSENSENISYHLTEPSSFVPLVPQHSFSSLPVKVESGKIQEPFSAMSKSTVSTSHSII 826
+L E + E + + +L + E + Q+ + + +
Sbjct: 1415 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK------RQAQEEAERLR 1468
Query: 827 SQMHDRPLLPSENITAQQGNMKALQEQLDLQKKVLQATQE----AQEQLLLCKQKEVEQQ 882
Q+ D + +KA E +++ LQA +E A+E +Q EVE+
Sbjct: 1469 RQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1528
Query: 883 TGLSVFLPLVTPDSSALLPSAKADLGRIQESSPTKNNIAVSSDHHVISQLQDK------- 935
+ V L + A L S +A + ++ +H ++QL+++
Sbjct: 1529 RQVQVALETAQRSAEAELQSKRASFAE----KTAQLERSLQEEHVAVAQLREEAERRAQQ 1584
Query: 936 --------------------------RLSLSQPILSQQNNFKFLQEQLNIQKDSLQARRE 969
RL L ++QQ + + + ++ +ARR
Sbjct: 1585 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1644
Query: 970 AQEVLYVHKQSELDRRVCSEQ---AEPSFPFQVAQHTFTSLPSADTKSGKIQEQHSSKSE 1026
+ +Q EL + +Q AE + ++A A+T+ G EQ E
Sbjct: 1645 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG---EQQRQLLE 1701
Query: 1027 KGLVSCQSDIPISQDGSLSFLQQFLPLHDSLKLLQEQLTKQRDTLQARHEA---QVELLL 1083
+ L Q + + + + +++L + + ++ E ++E
Sbjct: 1702 EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA 1761
Query: 1084 HRQRDLGDSKSGLVS---------------SSSSPVVVQHSVASQASAKAEPRRIQ---E 1125
R R+L + + L + ++ + +A + +A E R++ E
Sbjct: 1762 GRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE 1821
Query: 1126 LYLSEKENVGPSCHLIIP--TFQDKSLS--FPQHSLAQQENLTILQEQS----------- 1170
+ L EKE + FQ + L QH +E L L++ S
Sbjct: 1822 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV 1881
Query: 1171 --------QIQRVILGAKEGTQEFVHTESELEK---RISSEQTGTSSSLSQVD------- 1212
Q++ IL K ++ ++ELE RI S T S Q +
Sbjct: 1882 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1941
Query: 1213 ------------ESERFQECISIKSDST------------IPLSHPKIPRCQERLLRVSQ 1248
ER Q+ ++ + ++ + + R +ER + S
Sbjct: 1942 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2001
Query: 1249 HMLPLQDNLEEHQAWLDTEKEAFHFSQKTQENTSSEQTGSSSFIPQLVQLSFTSLASAES 1308
L L + + + + AF QK QE + Q S L QL + A+ +
Sbjct: 2002 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV----LDQLRGEAEAARRA 2057
Query: 1309 GTILEPLFTESESKIFSSHLQIPQLQDRLLRISQLIQPQQDNLKALQEQLATQREAIILA 1368
E ++E + S Q+ + + RL + ++ + +A E+L + E
Sbjct: 2058 AEEAEEARVQAEREAAQSRRQVEEAE-RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2116
Query: 1369 RQEAREELLLHQSEWEGRISPEQVDTSSLPLVPQHSFASLPLNESERNQEPCSINSDNIV 1428
R +A + L Q + + FA L + + ++ + +
Sbjct: 2117 RAQAEQAAL------------RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2164
Query: 1429 SSGHS------EIPTLPDGLLGLSHLVLPQQDNLIALEEHLHAQTDFLPSIEKTQKELVL 1482
+ H E+ L + ++ L ++ + + IE + L+L
Sbjct: 2165 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2224
Query: 1483 SKPCKFEEKVSSEHFIQSHHGDLQALQQQLDTQKKAIRSIQEVQEELLLQRLSELEKRVS 1542
+K +++ F+Q + ++ ++A R QE L++L+E + ++
Sbjct: 2225 ------RDKDNTQRFLQ------EEAEKMKQVAEEAARLSVAAQEAARLRQLAEED--LA 2270
Query: 1543 SEQVCSSSFVSQVPVADSERTQKSFPTKSNDTLPSSHREIPRLQDRLLSLSKPILPQQ-- 1600
++ + + + A E T+ K+ L +E+ + Q R L K + QQ
Sbjct: 2271 QQRALAEKMLKEKMQAVQEATR----LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2326
Query: 1601 ---DNMTAQLDAQREVMYSYEKPQEELSLNKQRKLNKSESAEHTIPSLFLPKETEHSFIP 1657
L+A+R+ E L L AE K+ E
Sbjct: 2327 EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF--RKQAEEIGEK 2384
Query: 1658 LPFAEAKPKS------TCELYSSQNEHAAPPSNPVIPGFQDRLLSFSQS-----VLTQQD 1706
L E + T E+ Q++H A I + Q + +++
Sbjct: 2385 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2444
Query: 1707 NLGLQKQLDLQREVLHYSQKAQEKLLVQRQTALQQQIQKHEETLKDFFKDSQISKPTVEN 1766
Q+QL + + L S +++ L+QR+ ++Q+ K E+ +D +Q + E
Sbjct: 2445 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE--EQ 2502
Query: 1767 DLKTQKMGQLRDWFPNTQDLAGNDQENIRHADRNNSDD 1804
+ Q+M Q R + + A Q R ++
Sbjct: 2503 QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE 2540
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 73.9 bits (180), Expect = 2e-12
Identities = 305/1563 (19%), Positives = 588/1563 (37%), Gaps = 252/1563 (16%)
Query: 35 LQVREQERDIALQIREDIKQRRNQQFTRLAEELRAEWEESQTQKIQNLEKLYLASLRSMG 94
LQ R ERD+ ++ R ++ +L E +A ++ ++ + L +G
Sbjct: 1300 LQQRHGERDVEVE-------RWRERVAQLLERWQAVLAQTDVRQRE---------LEQLG 1343
Query: 95 EGHRQAKENEPDLDALAQRAAERKRKAD---LRHKEALKVQKNQKEILLKQKTWHIKARK 151
R +E+ L A Q A R+ + L +A++ Q Q++ LL++ H + +
Sbjct: 1344 RQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVE 1403
Query: 152 EALLVEKERSAKITSLPPPPPTLFENIEVKRISAVKTNSST--------YHHLHTFVNRE 203
E K+ I T +E A K + Y L T +
Sbjct: 1404 ECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSEL 1463
Query: 204 TDTKRPDARLAAE-----EEAKRLEELQKQAAQERMERFEKAHVRGFQAMKKIHLAQNQ- 257
T + +E EE +RL E Q+ +ER+ E A + Q + A+ Q
Sbjct: 1464 TTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQA 1523
Query: 258 EKLMKELKQLQQEDLARRRQTVAQMPPQLVELPYKRSEMKEDWQRELEFAFEDMYNADR- 316
E+ KEL+Q QE++ RR + Q + + ++++ + E++ A+R
Sbjct: 1524 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS 1583
Query: 317 --KVKGNL-ILHLEPEPLPTVTNQIQDEELDLSMEQENLGAAEDLPVTEAEICSSETDVP 373
+++ + ++ L+ E + E L E A + EAE +
Sbjct: 1584 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1643
Query: 374 LVMKTQ---QIPSKVL--FKKLLNKIRSQKSLWTIKSMSED------------------- 409
K Q ++ S+V + K R+ ++L ++ +E+
Sbjct: 1644 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1703
Query: 410 -ESEMITTVSEIESKAPTVESGTIASKERTLSSGQEQVVESDTLTIESGPLASEDKPLSC 468
E+ + +E++SK + T A ER+L QE+ V L E+ A +
Sbjct: 1704 LETAQRSAEAELQSKRASFAEKT-AQLERSL---QEEHVAVAQLREEAERRAQQQAEAER 1759
Query: 469 GTNSGKEQ------EINETLPI----------TTVAQSSVLLHPQEAAARIR-------M 505
+ + + NE L + ++AQ+ +EA R
Sbjct: 1760 AREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQ 1819
Query: 506 SARQKQIMEIEEQKQKQL-------------ELL------EQIEQQKLRLETDCFRAQLE 546
+ RQ+++ E E +KQ+QL EL+ EQ EQQ+ LE + R Q E
Sbjct: 1820 AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1879
Query: 547 ----EEKRKKTQPTGVGIAPASCPVI------SDEDSHRQMIRNYQHQLLQQNRLHRQSV 596
+KR++ + + A V+ ++E+S ++ Q + R +
Sbjct: 1880 AAAATQKRQELE-AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1938
Query: 597 ETARKQLLEYQTMLKGRCPS-------VSAPSLITDSVISV---PSWKSERPTAISEHWD 646
E AR + L + + + A ++ + + ++ K+E A+ E
Sbjct: 1939 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1998
Query: 647 QGQRLKLSPNKYQPIQPIQTSKLEQDHFQVARQNHFPQRQVETTETLRASDI-LTNQALE 705
+ +RL+ + + Q +LE+ Q H + + +ASD L Q
Sbjct: 1999 ENERLR----RLAEDEAFQRRRLEEQAAQ-----HKADIEERLAQLRKASDSELERQKGL 2049
Query: 706 SQEHLRQFSQTETQQRDYKLVPKDSETLSRALSHDRQLISQDARKISETFGATTFQSLES 765
++ LRQ Q E + K + + L + I +A + ++
Sbjct: 2050 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 2109
Query: 766 QQLFSENSENISYHLTEPSSFVPLVPQHSFSSLPVKVESGKIQEPFSAMSKSTVSTSHSI 825
+QL +E E V Q S ++ +E + K+ + +
Sbjct: 2110 RQLAAEEER----RRREAEERV----QKSLAA----------EEEAARQRKAALEEVERL 2151
Query: 826 ISQMHDRPLLPSENITAQQGNMKALQEQLDLQKKVLQATQEAQEQLLLCKQKEVEQ--QT 883
+++ + L A+Q + + LQ + +K LQA ++A + K++E++Q Q
Sbjct: 2152 KAKVEEARRLRER---AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2208
Query: 884 GLSVFLPLVTPDSSALLPSAKADLGRIQ-ESSPTKNNIAVSSDHHVISQLQDKRLSLSQP 942
SV L +A + +A+ R+Q E ++ V + +++ + +Q
Sbjct: 2209 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQA 2268
Query: 943 ILSQQNNFKFLQEQLNIQKDSLQARR-EAQEVLYVHKQ---SELDRRVCSEQAEPSFPFQ 998
+ E+L + + ARR +A++ KQ +E+++ + Q
Sbjct: 2269 --------QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQ 2320
Query: 999 VAQHTFT---SLPSADTKSGKIQEQHSSKSEKGLVSCQSDIPISQDGSLSFLQQFLPLHD 1055
V Q T L D + + E+ + + + + ++
Sbjct: 2321 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE------------LF 2368
Query: 1056 SLKLLQEQLTKQRDTLQARHEAQVELLLHRQRDLGD---SKSGLVSSSSSPVVVQHSVAS 1112
S+++ E+L+K L+AR EA+ L+ R +D + + + SVA+
Sbjct: 2369 SVRVQMEELSK----LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2424
Query: 1113 QASAK---------AEPRRIQELYLSEK-ENVGPSCHLIIPTFQDKSLSFPQHSLAQQEN 1162
Q +A+ A+ R + E L EK + V + L + L Q LAQ++
Sbjct: 2425 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL----KAEAELLQQQKELAQEQA 2480
Query: 1163 LTILQEQSQIQRVILGAKEGTQEFVHTESELEKRISSEQTGTSSSLSQV--------DES 1214
+ +++ Q+ + + +G Q + E + + +S+E ++++ +++
Sbjct: 2481 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2540
Query: 1215 ERFQ---ECISIKSDSTIPLSHPKIPRCQ--ERLLRVSQHMLPLQDNLEEHQAWLDTEKE 1269
+RF+ E I K T + K+ Q E + S H + L E A L+ EKE
Sbjct: 2541 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD---AERLREAIAELEREKE 2597
Query: 1270 AFHFSQKTQENTSSE-QTGSSSFIPQLVQLSFTSLASAESGTILEPLFTESESKIFSSHL 1328
K + S E QT + Q Q S S + + F E E
Sbjct: 2598 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK------A 2651
Query: 1329 QIPQL-QDRLLRISQLIQPQQDNLKALQEQLATQREAIILARQEAREELLLHQSEWEGRI 1387
++ QL QD + + QL + QQ Q+Q+ +R+ ++ + +EAR Q E E +
Sbjct: 2652 KLEQLFQDEVAKAQQLREEQQRQ----QQQMEQERQRLVASMEEARR----RQHEAEEGV 2703
Query: 1388 SPEQVDTSSLP---------LVPQHSFASLPLNESERNQEPCSINSDNIVSSGHSEIPTL 1438
+Q + L L ++ L E +S+ + +S + TL
Sbjct: 2704 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTL 2763
Query: 1439 PDG 1441
P+G
Sbjct: 2764 PNG 2766
Score = 73.6 bits (179), Expect = 2e-12
Identities = 238/1240 (19%), Positives = 472/1240 (38%), Gaps = 148/1240 (11%)
Query: 10 KLRLSPNEEAFILKEDYERRRKLRLLQVREQERDIALQIREDIKQRRNQQFTRLAEELRA 69
+LR S E E + RL ++ E+ R + LQ+ +QR + A RA
Sbjct: 1561 QLRQSSEAEIQAKARQAEAAERSRL-RIEEEIRVVRLQLEATERQRGGAEGELQALRARA 1619
Query: 70 EWEESQTQKIQNLEKLYLASLRSMGEGHRQAKENEPDLDALAQRAAERKRKADLRHKEAL 129
E E+Q ++ Q + ++ + RQA E E A+ A R+++ L+ E L
Sbjct: 1620 EEAEAQKRQAQEEAERLRRQVQDESQRKRQA-EVELASRVKAEAEAAREKQRALQALEEL 1678
Query: 130 KVQKNQKEILLKQKTWHIKARKEALLVEKERSAKITSLPPPPPTLFENIEVKRISAVKTN 189
++Q + E L+Q + + L +RSA+ ++ KR S +
Sbjct: 1679 RLQAEEAERRLRQAEVERARQVQVALETAQRSAE------------AELQSKRASFAEKT 1726
Query: 190 SSTYHHLHTFVNRETDTKRPDARLAAEEEAKRLEELQKQAAQERMER-FEKAHVRGFQAM 248
+ L + A+L E E + ++ + + A+E ER E+ ++ +A+
Sbjct: 1727 AQLERSLQ-------EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1779
Query: 249 KKIHLAQNQEKLMKELKQLQQEDLARRRQTVAQMPPQLVELPYKRSEMKE---DWQREL- 304
++ L + K L Q + E + A+ + E ++ E+ E + QR+L
Sbjct: 1780 -RLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLA 1838
Query: 305 EFAFEDMYNADRKVKGNLILHLEPEPLPTVTNQIQDEELDLSMEQENLGAAEDLPVTEAE 364
E + A++++ + L E E Q+ +EEL +++E A + EAE
Sbjct: 1839 EGTAQQRLAAEQEL---IRLRAETEQ-GEQQRQLLEEEL-ARLQREAAAATQKRQELEAE 1893
Query: 365 ICS--SETDVPLVMKTQ-QIPSKVLFKKLLNKIRSQKSLWTIKSMSEDESEMITTVSEIE 421
+ +E +V L K + + S+ +K +K R + + ++E+ + + E +
Sbjct: 1894 LAKVRAEMEVLLASKARAEEESRSTSEK--SKQRLEAEAGRFRELAEEAARLRALAEEAK 1951
Query: 422 SKAPTVESGTI---ASKERTLSSGQEQVVESDTLTIESGPLASEDKPLSCGTNSGKEQEI 478
+ E A ER L+ + E+ L E+ E + + E E
Sbjct: 1952 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 2011
Query: 479 NETLPITTVAQSSVLLHPQEAAARIRMSA-----RQKQIME--IEEQKQKQLELL----- 526
+ + A + +E A++R ++ RQK ++E + +++Q + E+L
Sbjct: 2012 FQRRRLEEQA-AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKAS 2070
Query: 527 ---EQIEQQKLRLETDCFRAQLEEEKRKKTQPTGVGIAPASCPVISDEDSHRQMIRNYQH 583
+ +L LE R+ E+ R K Q + A +E R+ Q
Sbjct: 2071 FEKAAAGKAELELELGRIRSNAEDTLRSKEQ-AELEAARQRQLAAEEERRRREAEERVQK 2129
Query: 584 QLLQQNRLHRQSVETAR-----KQLLEYQTMLKGRCPSVSAPSLITDSVISVPSWKSERP 638
L + RQ K +E L+ R SA L + ++E
Sbjct: 2130 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK 2189
Query: 639 TAISEHWDQGQRLKLSPNKYQPI----------QPIQTSKLEQDHFQVARQNHFPQRQVE 688
+ Q L+ + + Q + + E+ Q R+ +RQVE
Sbjct: 2190 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2249
Query: 689 TTETLRASDILTNQALESQEHLRQFSQTETQQRDYKLVPKDSETLSRALSHDRQLISQDA 748
E L+ S QA + + + E +Q + + L + + D ++ +
Sbjct: 2250 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM--EKH 2307
Query: 749 RKISETFGATTFQSLESQQLFSENSENISYHLTEPSSFVPLVPQHSFSSLPVKVESGKIQ 808
+K +E Q+L + + + L E H + L +++ K +
Sbjct: 2308 KKFAE-------QTLRQKAQVEQELTTLRLQLEE--------TDHQKNLLDEELQRLKAE 2352
Query: 809 EPFSAMSKSTVSTS-HSIISQMHD----RPLLPSEN----ITAQQGNMKALQEQLDLQKK 859
+A +S V S+ QM + + + +EN + + + LQE+ + K+
Sbjct: 2353 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2412
Query: 860 VLQ-------ATQEAQEQLLLCKQKEVEQQTGLSVFLPLVTPDSSALLPSAKADLGRIQE 912
V + A QEA +L ++++ QQ L+ + K + +QE
Sbjct: 2413 VAEEAARLSVAAQEA-ARLRQLAEEDLAQQRALAEKM-------------LKEKMQAVQE 2458
Query: 913 SSPTKNNIAVSSDHHVISQLQDKRL-----SLSQPILSQQNNFKFL-----QEQLNIQKD 962
++ K + ++Q Q +RL ++Q + + F+ Q QL + +
Sbjct: 2459 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE 2518
Query: 963 SLQARREAQEVLYVHKQSELDRRVCSEQAEPSFPFQVAQHTFTSLPSADTKSGKIQEQHS 1022
+ + + E+ ++E D + +QAE T ++ +IQ Q S
Sbjct: 2519 AERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2578
Query: 1023 SKSEKGLVSCQSDI-----PISQDGSLSFLQQFLPLHDSLKLLQEQLTKQRDTLQARHEA 1077
+ L +++ + Q+ L L+ + + QEQL ++ LQ +
Sbjct: 2579 DHDAERLREAIAELEREKEKLQQEAKLLQLKS----EEMQTVQQEQLLQETQALQQSFLS 2634
Query: 1078 QVELLLHRQRDLGDSKSGLVSSSSSPVVVQHSVASQASAKAEPRRIQELYLSEKENVGPS 1137
+ + LL R+R + K+ L + Q VA + E +R Q+ E++ + S
Sbjct: 2635 EKDSLLQRERFIEQEKAKLEQ------LFQDEVAKAQQLREEQQRQQQQMEQERQRLVAS 2688
Query: 1138 CHLIIPTFQDKSLSFPQHSLAQQENLTILQEQSQIQRVIL 1177
+ + + + +QE L L++Q + Q +L
Sbjct: 2689 ----MEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2724
Score = 69.7 bits (169), Expect = 4e-11
Identities = 209/1051 (19%), Positives = 404/1051 (38%), Gaps = 170/1051 (16%)
Query: 17 EEAFILKEDYERRRKLRLLQVREQER---DIALQIREDIKQRRNQQFTRLAEE---LRAE 70
E+A + + ER +L + E R + + ++E K+ N++ RLAE+ R
Sbjct: 1959 EDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE--KEAENERLRRLAEDEAFQRRR 2016
Query: 71 WEESQTQKIQNLEKLYLASLRSMGEGH---------------RQAKENEPDLDALAQRAA 115
EE Q ++E+ LA LR + RQ +E L A ++AA
Sbjct: 2017 LEEQAAQHKADIEER-LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA 2075
Query: 116 ERKRKADLRHKEALKVQKNQKEILLKQKTWHIKA-RKEALLVEKERSAKITSLPPPPPTL 174
K + +L E +++ N ++ L ++ ++A R+ L E+ER
Sbjct: 2076 AGKAELEL---ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR------------- 2119
Query: 175 FENIEVKRISAVKTNSSTYHHLHTFVNRETDTKRPDARLAAEEEAKRLEE---------- 224
+R + + S R+ + + A EEA+RL E
Sbjct: 2120 ------RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2173
Query: 225 -LQKQAAQERMERFEKAHVRGFQAMKKIHLAQNQEKLMKELKQLQQE-DLARRRQTVAQM 282
L ++AAQ+R++ EKAH Q K+ L Q ++ L QL+ E + ARR A+
Sbjct: 2174 QLAQEAAQKRLQAEEKAHAFAVQ-QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2232
Query: 283 PPQLVELPYKRSEMKEDWQRELEFAFEDMYNADRKVKGNLILHLEPEPLPTVTNQIQDEE 342
E +S + + L+ + E+ A + + L E + Q E+
Sbjct: 2233 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA-AAEKLRKEAEQEAARRAQAEQ 2291
Query: 343 LDLSMEQ-------ENLGAAEDLPVTEAEICSSETDVPLVMKTQQIPSKVLFKKLLN--- 392
L +Q ++ AE +A++ T + L ++ +L ++L
Sbjct: 2292 AALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKA 2351
Query: 393 ------KIRSQ--KSLWTIKSMSEDESEMITTVSEIESKAPTVESGTIASKERTLSSGQE 444
+ RSQ + L++++ E+ S++ + E E++A + K+ T QE
Sbjct: 2352 EATEAARQRSQVEEELFSVRVQMEELSKLKARI-EAENRAL-----ILRDKDNTQRFLQE 2405
Query: 445 QVVESDTLTIESGPLASEDKPLSCGTNSGKEQEINETLPITTVAQSSVLLHPQEA---AA 501
+ + + E+ L+ ++ + Q E L +L +A A
Sbjct: 2406 EAEKMKQVAEEAARLS-----VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT 2460
Query: 502 RIRMSAR--QKQIMEIEEQKQKQLELLEQIEQQKLRLETDCFRAQLEEEKRKKTQPTG-- 557
R++ A Q+Q +EQ ++ E EQ+ QQ L ET F+ LE E++++ + +
Sbjct: 2461 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ-LAEETQGFQRTLEAERQRQLEMSAEA 2519
Query: 558 ----VGIAPAS-CPVISDEDSHRQMIRNYQHQLLQQNRLHRQSVETARKQLLEYQTMLKG 612
+ +A S ++ED+ R R ++ +LHR + T K L QT+
Sbjct: 2520 ERLKLRVAEMSRAQARAEEDAQR--FRKQAEEI--GEKLHRTELATQEKVTL-VQTLEIQ 2574
Query: 613 RCPSVSAPSLITDSVISVPSWKS--ERPTAISEHWDQGQRLKLSPNKYQPIQPIQTSKLE 670
R S + +++ + K ++ + + + + Q Q +Q S L
Sbjct: 2575 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2634
Query: 671 QDHFQVARQNHFPQRQVETTETLRASDILTNQALESQEHLRQFSQTETQQ-----RDYKL 725
+ + R+ Q + + + + Q E Q+ +Q + E Q+ + +
Sbjct: 2635 EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2694
Query: 726 VPKDSETLSRALSHDRQLISQDARKISETFGATTFQSLESQQLFSE-------NSENISY 778
++E R + Q + Q R+ E + E QL E +SE ++
Sbjct: 2695 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2754
Query: 779 HLTEPSSFVP------------LVPQHSFSSLPVKVESGKIQEP--FSAMSKSTVSTSHS 824
+ +P P+HSF L KV + ++QE SA ++ H+
Sbjct: 2755 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2814
Query: 825 IISQMHDRPLLPSENITAQQGNMKALQEQLDLQKKVLQATQEAQEQLLLCKQKEVEQQTG 884
+ ++ R + LQ + + +L+AT E L +++Q
Sbjct: 2815 TVDELARR-----------EDVRHYLQGRSSIAGLLLKATNEK-----LSVYAALQRQ-- 2856
Query: 885 LSVFLPLVTPDSSALLPSAKADLG---------RIQESSPTKNNIAVSSDHHVISQLQDK 935
L++P ++ +L A+A G R+ + K + HH + +
Sbjct: 2857 ------LLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERA 2910
Query: 936 RLSLSQPILSQQ-NNFKFLQEQLNIQKDSLQ 965
P QQ + F+ +Q+ L +++ ++
Sbjct: 2911 VTGYKDPYTGQQISLFQAMQKGLIVREHGIR 2941
Score = 66.2 bits (160), Expect = 4e-10
Identities = 325/1784 (18%), Positives = 662/1784 (37%), Gaps = 255/1784 (14%)
Query: 50 EDIKQRRNQQFTRLAEELRAEWEESQT----QKIQNLEKLYLASLRSMGEGHRQAKENEP 105
+DI+ + TR LR ++ Q+I +K A + +G+G +
Sbjct: 1127 KDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQ-AEVEGLGKGVARLSAEAE 1185
Query: 106 DLDALAQ---RAAERKRKADLRHKEALKVQKNQKEILLKQKTWHIKAR-----KEALLVE 157
+ AL + A + + +L + +V+ L K KT + R +E L
Sbjct: 1186 KVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH 1245
Query: 158 KERSAKITSLPPPPPTLFENIEVKRISAVKTNSSTYHHLHTFVNRETDTKRPDARLAAEE 217
+E+ + ++P P L E + S K + TF D R + R A+E
Sbjct: 1246 EEQLKEAQAVPATLPEL----EATKASLKKLRAQAEAQQPTF-----DALRDELR-GAQE 1295
Query: 218 EAKRLEEL--QKQAAQERM-ERFEKAHVRGFQAMKKIHLAQNQ-EKLMKELKQLQQ---- 269
+RL++ ++ ER ER + R + + + Q + E+L ++L+ ++
Sbjct: 1296 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADP 1355
Query: 270 -----EDLARRRQTVAQMPPQLVELPYKRSEMKEDWQ--RELEFAFEDMYNADRKVKGNL 322
+D RR++ + MP L + R +++++ E+E E + R K
Sbjct: 1356 LGAWLQDARRRQEQIQAMP--LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAK-QY 1412
Query: 323 ILHLEPEPLPTVTNQIQDEELDLSMEQENLGAAEDLPVTEAEICSSETDVPLVMKTQQIP 382
I ++ L VT + Q E + ++ + + + + E + + +Q I
Sbjct: 1413 INAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK 1472
Query: 383 SKVLFKKLLNKIRSQKSLWTIKSMSEDESEMITTVSEIESKAPTVESGTIASKERTLSSG 442
+ L ++ ++ L + +E+ + + +E + E+ A + +
Sbjct: 1473 ---FISETLRRMEEEERL-AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK 1528
Query: 443 ------QEQVVESDTLTIESGPLASEDKPLSCGTNSGKEQEINETLPITTVAQSSVLLHP 496
QE+VV + +++ + E EI A+ S L
Sbjct: 1529 ELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1588
Query: 497 QEA-AARIRMSARQKQIMEIEEQKQKQLELLEQIEQQKLRL--ETDCFRAQLEEEKRKKT 553
+E R+++ A ++Q E + Q E+ E QK + E + R Q+++E ++K
Sbjct: 1589 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR 1648
Query: 554 QPTGVGIAPASCPVISDEDSHRQMIRNYQHQLLQQNRLHRQSVETARKQLLEYQTMLKGR 613
Q A + S + + R Q L L Q+ E R+ L + + R
Sbjct: 1649 Q--------AEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR--LRQAEVERAR 1698
Query: 614 CPSVSAPSLITDSVISVPSWKSERPTAISEHWDQGQRLKLSPNKYQPIQPIQTSKLEQDH 673
V+ + + + S ++ + +E Q +R L+++H
Sbjct: 1699 QVQVALETAQRSAEAELQSKRA----SFAEKTAQLER-----------------SLQEEH 1737
Query: 674 FQVARQNHFPQRQVET-TETLRASDI----LTNQALESQEHLRQFSQTETQQRDYKLVPK 728
VA+ +R+ + E RA + L L++ E LR Q E + L
Sbjct: 1738 VAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQA 1797
Query: 729 DSETLSRALSHDRQLISQDARKISETFGATTFQSLESQQLFSENSENISYHLTEPSSFVP 788
++E ++A + + G Q++ ++L + E L E ++
Sbjct: 1798 EAEKQK-----------EEAEREARRRGKAEEQAVRQRELAEQELEK-QRQLAEGTAQQR 1845
Query: 789 LVPQHSFSSLPVKVESGKIQEPFSAMSKSTVSTSHSIISQMHDRPLLPSENITAQQGNMK 848
L + L + E G+ Q R LL E Q+
Sbjct: 1846 LAAEQELIRLRAETEQGEQQ-----------------------RQLLEEELARLQREAAA 1882
Query: 849 ALQEQLDLQKKVLQATQEAQEQLLLCKQKEVEQQTGLSVFLPLVTPDSSALLPSAKADLG 908
A Q++ +L+ ++ A A+ ++LL + E+++ + S +A+ G
Sbjct: 1883 ATQKRQELEAEL--AKVRAEMEVLLASKARAEEESRST---------SEKSKQRLEAEAG 1931
Query: 909 RIQESSPTKNNIAVSSDHHVISQLQDKRLSLSQPILSQQNNFKFLQEQLNIQKDSLQARR 968
R +E + + ++ + ++L+ + + L E+L ++ + +
Sbjct: 1932 RFRELAEEAARLRALAEE----AKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT 1987
Query: 969 EAQEVLYVHKQSELDR--RVCSEQA--EPSFPFQVAQHTFTSLPSADTKSGKIQEQHSSK 1024
EA E+ K++E +R R+ ++A Q AQH AD + Q + +S
Sbjct: 1988 EA-EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH------KADIEERLAQLRKASD 2040
Query: 1025 SE----KGLV--SCQSDIPISQDGSLSFLQQFLPLHDSLKLLQEQLTKQR----DTLQAR 1074
SE KGLV + + + ++ L+ F L+ +L + R DTL+++
Sbjct: 2041 SELERQKGLVEDTLRQRRQVEEE-ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSK 2099
Query: 1075 HEAQVELLLHRQRDLGDSKSGLVSSSSSPVVVQHSVASQASAKAEPRRIQELYLSEKENV 1134
+A++E RQ + + + VQ S+A++ A + + E K V
Sbjct: 2100 EQAELEAARQRQLAAEEERRRREAEER----VQKSLAAEEEAARQRKAALEEVERLKAKV 2155
Query: 1135 GPSCHLIIPTFQD--KSLSFPQ-------------HSLAQQENLTILQEQSQIQRVILGA 1179
+ L Q+ + L Q H+ A Q+ LQ+ Q ++ +L
Sbjct: 2156 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2215
Query: 1180 KEGTQEFVHTESEL--EKRISSEQTGTSSSLSQVDESERFQECISIKSDSTIPLSHPKIP 1237
G E +E E R+ +E+ S QV+E+ER ++ ++ +
Sbjct: 2216 LRGEAEAARRAAEEAEEARVQAEREAAQSR-RQVEEAERLKQSAEEQAQARAQAQAAAEK 2274
Query: 1238 RCQERLLRVSQHMLPLQDNLEEHQAW-LDTEKEAFHFSQKTQENTSSEQTGSSSFIPQLV 1296
+E ++ Q L + QA + EK Q ++ EQ +L
Sbjct: 2275 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ--------ELT 2326
Query: 1297 QLSFTSLASAESGTILEPLFTESESKIFSSHLQIPQLQDRLLRISQLIQPQQDNLKALQE 1356
L + +L+ +++ + Q Q+++ L + + Q + L L+
Sbjct: 2327 TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV----RVQMEELSKLKA 2382
Query: 1357 QLATQREAIILARQEAREELLLHQSEWEGRISPEQVDTSSLPLVPQHSFASLPLNESERN 1416
++ + A+IL ++ + L ++E +++ E + L + Q + L E +
Sbjct: 2383 RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE---AARLSVAAQEAARLRQLAEEDLA 2439
Query: 1417 QEPCSINSDNIVSSGHSEIPTLPDGLLGLSHLVLPQQDNLIALEEHLHAQTDFLPSIEKT 1476
Q+ L+ +L ++ + L A+ + L +
Sbjct: 2440 QQRA------------------------LAEKMLKEKMQAVQEATRLKAEAELL----QQ 2471
Query: 1477 QKELVLSKPCKFEEKVSSEHFIQSHHGDLQALQQQLDTQKKAIRSIQEVQEELLLQRLSE 1536
QKEL + + +E E Q + Q Q+ L+ +++ + E L L R++E
Sbjct: 2472 QKELAQEQARRLQE--DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL-RVAE 2528
Query: 1537 LEKRVSSEQVCSSSFVSQVPVADSERTQKSFPTKSNDTL--------PSSHREIPRLQDR 1588
+ + + + + F Q + + T+ TL S + RL++
Sbjct: 2529 MSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA 2588
Query: 1589 LLSLSKPILP-QQDNMTAQLDAQREVMYSYEKPQEELSLNKQRKLNKSESAEHTIPSLFL 1647
+ L + QQ+ QL ++ E+ +E +Q L++ +S F+
Sbjct: 2589 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR--ERFI 2646
Query: 1648 PKETEHSFIPLPFAEAKPKSTCELYSSQNEHAAPPSNPVIPGFQD---RLLSFSQSVLTQ 1704
+E AK + E Q + ++ ++ R + V +
Sbjct: 2647 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2706
Query: 1705 QDNLGLQKQLDLQREVLHYSQKAQEKLLVQRQTALQQQIQKHEE 1748
Q+ L +QL+ QR + QE+LL + L++Q+Q EE
Sbjct: 2707 QEEL---QQLEQQR-------RQQEELLAEENQRLREQLQLLEE 2740
Score = 65.5 bits (158), Expect = 7e-10
Identities = 317/1778 (17%), Positives = 637/1778 (35%), Gaps = 269/1778 (15%)
Query: 228 QAAQERMERFEKAHVRGFQAMKKIHLAQNQ----EKLMKELKQLQQEDLARRRQTVAQMP 283
Q AQE + R E H ++H+ + L ++++ ++ LA R +
Sbjct: 1000 QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQ 1059
Query: 284 PQLV---ELPYKRSEMKEDWQRELEFAFEDMYNADRKVKGNLILHLEPEPLPTVTNQIQD 340
Q + EL Y+ D Q F ED A+R+ G+ H + + L ++ Q+
Sbjct: 1060 RQALHSLELHYQA--FLRDSQDAGGFGPEDRLMAEREY-GSCSHHYQ-QLLQSLEQGAQE 1115
Query: 341 EELDLSMEQENLGAAEDLPVTEAEICSSETDVPLVMKTQQIPSKVLFKKLLNKIRSQ--- 397
E S Q + +D+ + + E C + T L + + P++ +++ + ++Q
Sbjct: 1116 E----SRCQRCISELKDIRL-QLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEV 1170
Query: 398 KSLWTIKSMSEDESEMITTVSEIESKAPTVESG---TIASKERTLSSGQEQVVESDTLTI 454
+ L + E+E + + E APT+ S T+ E+ S + + T+++
Sbjct: 1171 EGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISL 1230
Query: 455 ESGPLASEDKPLSCGTNSGKE-QEINETLPITTVAQSSV--------------------L 493
++ L KE Q + TLP ++S+ L
Sbjct: 1231 VIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDEL 1290
Query: 494 LHPQEAAARIRMSARQKQIMEIEEQKQKQLELLEQIEQQKLRLETDCFRAQLEE------ 547
QE R++ ++ + E+E +++ +LLE+ Q + +TD + +LE+
Sbjct: 1291 RGAQEVGERLQQRHGERDV-EVERWRERVAQLLER--WQAVLAQTDVRQRELEQLGRQLR 1347
Query: 548 EKRKKTQPTGVGIAPA-------SCPVISDEDSHRQMIRNYQHQLLQQNRLHRQSVETAR 600
R+ P G + A ++D + R+ +R Q LL++ H + VE +
Sbjct: 1348 YYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQ-ALLEEIERHGEKVEECQ 1406
Query: 601 KQLLEYQTMLKG---RCPSVSAPSLITDSVISVPSWKSERPTAISEHWD-QGQRLKLSPN 656
+ +Y +K + + A S P +S + I E+ D + +L+
Sbjct: 1407 RFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTL 1466
Query: 657 KYQPIQPI-QTSKLEQDHFQVARQNHFPQRQ--VETTETLRASDILTN-------QALES 706
Q I+ I +T + ++ ++A Q +R+ E L L QA
Sbjct: 1467 TSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAERE 1526
Query: 707 QEHLRQFSQTETQQRDYKLVPKDSETLSRALSHDRQLISQDARKISETFGATTFQSLESQ 766
+ L+Q Q E +R+ V D++ R++ + Q + Q + + A ++ E
Sbjct: 1527 AKELQQRMQEEVVRREEAAV--DAQQQKRSIQEELQQLRQSSEAEIQA-KARQAEAAERS 1583
Query: 767 QLFSENSENISYHLTEPSSFVPLVPQHSFSSLPVKVESGKIQEPFSAMSKSTVSTSHSII 826
+L E + E + + +L + E + Q+ + + +
Sbjct: 1584 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK------RQAQEEAERLR 1637
Query: 827 SQMHDRPLLPSENITAQQGNMKALQEQLDLQKKVLQATQE----AQEQLLLCKQKEVEQQ 882
Q+ D + +KA E +++ LQA +E A+E +Q EVE+
Sbjct: 1638 RQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1697
Query: 883 TGLSVFLPLVTPDSSALLPSAKADLGRIQESSPTKNNIAVSSDHHVISQLQDK------- 935
+ V L + A L S +A + ++ +H ++QL+++
Sbjct: 1698 RQVQVALETAQRSAEAELQSKRASFAE----KTAQLERSLQEEHVAVAQLREEAERRAQQ 1753
Query: 936 --------------------------RLSLSQPILSQQNNFKFLQEQLNIQKDSLQARRE 969
RL L ++QQ + + + ++ +ARR
Sbjct: 1754 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1813
Query: 970 AQEVLYVHKQSELDRRVCSEQ---AEPSFPFQVAQHTFTSLPSADTKSGKIQEQHSSKSE 1026
+ +Q EL + +Q AE + ++A A+T+ G EQ E
Sbjct: 1814 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG---EQQRQLLE 1870
Query: 1027 KGLVSCQSDIPISQDGSLSFLQQFLPLHDSLKLLQEQLTKQRDTLQARHEA---QVELLL 1083
+ L Q + + + + +++L + + ++ E ++E
Sbjct: 1871 EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA 1930
Query: 1084 HRQRDLGDSKSGLVS---------------SSSSPVVVQHSVASQASAKAEPRRIQ---E 1125
R R+L + + L + ++ + +A + +A E R++ E
Sbjct: 1931 GRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE 1990
Query: 1126 LYLSEKENVGPSCHLIIP--TFQDKSLS--FPQHSLAQQENLTILQEQS----------- 1170
+ L EKE + FQ + L QH +E L L++ S
Sbjct: 1991 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV 2050
Query: 1171 --------QIQRVILGAKEGTQEFVHTESELEK---RISSEQTGTSSSLSQVD------- 1212
Q++ IL K ++ ++ELE RI S T S Q +
Sbjct: 2051 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 2110
Query: 1213 ------------ESERFQECISIKSDST------------IPLSHPKIPRCQERLLRVSQ 1248
ER Q+ ++ + ++ + + R +ER + S
Sbjct: 2111 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2170
Query: 1249 HMLPLQDNLEEHQAWLDTEKEAFHFSQKTQENTSSEQTGSSSFIPQLVQLSFTSLASAES 1308
L L + + + + AF QK QE + Q S L QL + A+ +
Sbjct: 2171 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV----LDQLRGEAEAARRA 2226
Query: 1309 GTILEPLFTESESKIFSSHLQIPQLQDRLLRISQLIQPQQDNLKALQEQLATQREAIILA 1368
E ++E + S Q+ + + RL + ++ + +A E+L + E
Sbjct: 2227 AEEAEEARVQAEREAAQSRRQVEEAE-RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2285
Query: 1369 RQEAREELLLHQSEWEGRISPEQVDTSSLPLVPQHSFASLPLNESERNQEPCSINSDNIV 1428
R +A + L Q + + FA L + + ++ + +
Sbjct: 2286 RAQAEQAAL------------RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2333
Query: 1429 SSGHS------EIPTLPDGLLGLSHLVLPQQDNLIALEEHLHAQTDFLPSIEKTQKELVL 1482
+ H E+ L + ++ L ++ + + IE + L+L
Sbjct: 2334 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2393
Query: 1483 SKPCKFEEKVSSEHFIQSHHGDLQALQQQLDTQKKAIRSIQEVQEELLLQRLSELEKRVS 1542
+K +++ F+Q + ++ ++A R QE L++L+E + ++
Sbjct: 2394 ------RDKDNTQRFLQ------EEAEKMKQVAEEAARLSVAAQEAARLRQLAEED--LA 2439
Query: 1543 SEQVCSSSFVSQVPVADSERTQKSFPTKSNDTLPSSHREIPRLQDRLLSLSKPILPQQ-- 1600
++ + + + A E T+ K+ L +E+ + Q R L K + QQ
Sbjct: 2440 QQRALAEKMLKEKMQAVQEATR----LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2495
Query: 1601 ---DNMTAQLDAQREVMYSYEKPQEELSLNKQRKLNKSESAEHTIPSLFLPKETEHSFIP 1657
L+A+R+ E L L AE K+ E
Sbjct: 2496 EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF--RKQAEEIGEK 2553
Query: 1658 LPFAEAKPKS------TCELYSSQNEHAAPPSNPVIPGFQDRLLSFSQS-----VLTQQD 1706
L E + T E+ Q++H A I + Q + +++
Sbjct: 2554 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2613
Query: 1707 NLGLQKQLDLQREVLHYSQKAQEKLLVQRQTALQQQIQKHEETLKDFFKDSQISKPTVEN 1766
Q+QL + + L S +++ L+QR+ ++Q+ K E+ +D +Q + E
Sbjct: 2614 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE--EQ 2671
Query: 1767 DLKTQKMGQLRDWFPNTQDLAGNDQENIRHADRNNSDD 1804
+ Q+M Q R + + A Q R ++
Sbjct: 2672 QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE 2709
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 73.9 bits (180), Expect = 2e-12
Identities = 305/1563 (19%), Positives = 588/1563 (37%), Gaps = 252/1563 (16%)
Query: 35 LQVREQERDIALQIREDIKQRRNQQFTRLAEELRAEWEESQTQKIQNLEKLYLASLRSMG 94
LQ R ERD+ ++ R ++ +L E +A ++ ++ + L +G
Sbjct: 1141 LQQRHGERDVEVE-------RWRERVAQLLERWQAVLAQTDVRQRE---------LEQLG 1184
Query: 95 EGHRQAKENEPDLDALAQRAAERKRKAD---LRHKEALKVQKNQKEILLKQKTWHIKARK 151
R +E+ L A Q A R+ + L +A++ Q Q++ LL++ H + +
Sbjct: 1185 RQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVE 1244
Query: 152 EALLVEKERSAKITSLPPPPPTLFENIEVKRISAVKTNSST--------YHHLHTFVNRE 203
E K+ I T +E A K + Y L T +
Sbjct: 1245 ECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSEL 1304
Query: 204 TDTKRPDARLAAE-----EEAKRLEELQKQAAQERMERFEKAHVRGFQAMKKIHLAQNQ- 257
T + +E EE +RL E Q+ +ER+ E A + Q + A+ Q
Sbjct: 1305 TTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQA 1364
Query: 258 EKLMKELKQLQQEDLARRRQTVAQMPPQLVELPYKRSEMKEDWQRELEFAFEDMYNADR- 316
E+ KEL+Q QE++ RR + Q + + ++++ + E++ A+R
Sbjct: 1365 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS 1424
Query: 317 --KVKGNL-ILHLEPEPLPTVTNQIQDEELDLSMEQENLGAAEDLPVTEAEICSSETDVP 373
+++ + ++ L+ E + E L E A + EAE +
Sbjct: 1425 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1484
Query: 374 LVMKTQ---QIPSKVL--FKKLLNKIRSQKSLWTIKSMSED------------------- 409
K Q ++ S+V + K R+ ++L ++ +E+
Sbjct: 1485 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1544
Query: 410 -ESEMITTVSEIESKAPTVESGTIASKERTLSSGQEQVVESDTLTIESGPLASEDKPLSC 468
E+ + +E++SK + T A ER+L QE+ V L E+ A +
Sbjct: 1545 LETAQRSAEAELQSKRASFAEKT-AQLERSL---QEEHVAVAQLREEAERRAQQQAEAER 1600
Query: 469 GTNSGKEQ------EINETLPI----------TTVAQSSVLLHPQEAAARIR-------M 505
+ + + NE L + ++AQ+ +EA R
Sbjct: 1601 AREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQ 1660
Query: 506 SARQKQIMEIEEQKQKQL-------------ELL------EQIEQQKLRLETDCFRAQLE 546
+ RQ+++ E E +KQ+QL EL+ EQ EQQ+ LE + R Q E
Sbjct: 1661 AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1720
Query: 547 ----EEKRKKTQPTGVGIAPASCPVI------SDEDSHRQMIRNYQHQLLQQNRLHRQSV 596
+KR++ + + A V+ ++E+S ++ Q + R +
Sbjct: 1721 AAAATQKRQELE-AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1779
Query: 597 ETARKQLLEYQTMLKGRCPS-------VSAPSLITDSVISV---PSWKSERPTAISEHWD 646
E AR + L + + + A ++ + + ++ K+E A+ E
Sbjct: 1780 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1839
Query: 647 QGQRLKLSPNKYQPIQPIQTSKLEQDHFQVARQNHFPQRQVETTETLRASDI-LTNQALE 705
+ +RL+ + + Q +LE+ Q H + + +ASD L Q
Sbjct: 1840 ENERLR----RLAEDEAFQRRRLEEQAAQ-----HKADIEERLAQLRKASDSELERQKGL 1890
Query: 706 SQEHLRQFSQTETQQRDYKLVPKDSETLSRALSHDRQLISQDARKISETFGATTFQSLES 765
++ LRQ Q E + K + + L + I +A + ++
Sbjct: 1891 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1950
Query: 766 QQLFSENSENISYHLTEPSSFVPLVPQHSFSSLPVKVESGKIQEPFSAMSKSTVSTSHSI 825
+QL +E E V Q S ++ +E + K+ + +
Sbjct: 1951 RQLAAEEER----RRREAEERV----QKSLAA----------EEEAARQRKAALEEVERL 1992
Query: 826 ISQMHDRPLLPSENITAQQGNMKALQEQLDLQKKVLQATQEAQEQLLLCKQKEVEQ--QT 883
+++ + L A+Q + + LQ + +K LQA ++A + K++E++Q Q
Sbjct: 1993 KAKVEEARRLRER---AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2049
Query: 884 GLSVFLPLVTPDSSALLPSAKADLGRIQ-ESSPTKNNIAVSSDHHVISQLQDKRLSLSQP 942
SV L +A + +A+ R+Q E ++ V + +++ + +Q
Sbjct: 2050 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQA 2109
Query: 943 ILSQQNNFKFLQEQLNIQKDSLQARR-EAQEVLYVHKQ---SELDRRVCSEQAEPSFPFQ 998
+ E+L + + ARR +A++ KQ +E+++ + Q
Sbjct: 2110 --------QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQ 2161
Query: 999 VAQHTFT---SLPSADTKSGKIQEQHSSKSEKGLVSCQSDIPISQDGSLSFLQQFLPLHD 1055
V Q T L D + + E+ + + + + ++
Sbjct: 2162 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE------------LF 2209
Query: 1056 SLKLLQEQLTKQRDTLQARHEAQVELLLHRQRDLGD---SKSGLVSSSSSPVVVQHSVAS 1112
S+++ E+L+K L+AR EA+ L+ R +D + + + SVA+
Sbjct: 2210 SVRVQMEELSK----LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2265
Query: 1113 QASAK---------AEPRRIQELYLSEK-ENVGPSCHLIIPTFQDKSLSFPQHSLAQQEN 1162
Q +A+ A+ R + E L EK + V + L + L Q LAQ++
Sbjct: 2266 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL----KAEAELLQQQKELAQEQA 2321
Query: 1163 LTILQEQSQIQRVILGAKEGTQEFVHTESELEKRISSEQTGTSSSLSQV--------DES 1214
+ +++ Q+ + + +G Q + E + + +S+E ++++ +++
Sbjct: 2322 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2381
Query: 1215 ERFQ---ECISIKSDSTIPLSHPKIPRCQ--ERLLRVSQHMLPLQDNLEEHQAWLDTEKE 1269
+RF+ E I K T + K+ Q E + S H + L E A L+ EKE
Sbjct: 2382 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD---AERLREAIAELEREKE 2438
Query: 1270 AFHFSQKTQENTSSE-QTGSSSFIPQLVQLSFTSLASAESGTILEPLFTESESKIFSSHL 1328
K + S E QT + Q Q S S + + F E E
Sbjct: 2439 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK------A 2492
Query: 1329 QIPQL-QDRLLRISQLIQPQQDNLKALQEQLATQREAIILARQEAREELLLHQSEWEGRI 1387
++ QL QD + + QL + QQ Q+Q+ +R+ ++ + +EAR Q E E +
Sbjct: 2493 KLEQLFQDEVAKAQQLREEQQRQ----QQQMEQERQRLVASMEEARR----RQHEAEEGV 2544
Query: 1388 SPEQVDTSSLP---------LVPQHSFASLPLNESERNQEPCSINSDNIVSSGHSEIPTL 1438
+Q + L L ++ L E +S+ + +S + TL
Sbjct: 2545 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTL 2604
Query: 1439 PDG 1441
P+G
Sbjct: 2605 PNG 2607
Score = 73.6 bits (179), Expect = 2e-12
Identities = 238/1240 (19%), Positives = 472/1240 (38%), Gaps = 148/1240 (11%)
Query: 10 KLRLSPNEEAFILKEDYERRRKLRLLQVREQERDIALQIREDIKQRRNQQFTRLAEELRA 69
+LR S E E + RL ++ E+ R + LQ+ +QR + A RA
Sbjct: 1402 QLRQSSEAEIQAKARQAEAAERSRL-RIEEEIRVVRLQLEATERQRGGAEGELQALRARA 1460
Query: 70 EWEESQTQKIQNLEKLYLASLRSMGEGHRQAKENEPDLDALAQRAAERKRKADLRHKEAL 129
E E+Q ++ Q + ++ + RQA E E A+ A R+++ L+ E L
Sbjct: 1461 EEAEAQKRQAQEEAERLRRQVQDESQRKRQA-EVELASRVKAEAEAAREKQRALQALEEL 1519
Query: 130 KVQKNQKEILLKQKTWHIKARKEALLVEKERSAKITSLPPPPPTLFENIEVKRISAVKTN 189
++Q + E L+Q + + L +RSA+ ++ KR S +
Sbjct: 1520 RLQAEEAERRLRQAEVERARQVQVALETAQRSAE------------AELQSKRASFAEKT 1567
Query: 190 SSTYHHLHTFVNRETDTKRPDARLAAEEEAKRLEELQKQAAQERMER-FEKAHVRGFQAM 248
+ L + A+L E E + ++ + + A+E ER E+ ++ +A+
Sbjct: 1568 AQLERSLQ-------EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1620
Query: 249 KKIHLAQNQEKLMKELKQLQQEDLARRRQTVAQMPPQLVELPYKRSEMKE---DWQREL- 304
++ L + K L Q + E + A+ + E ++ E+ E + QR+L
Sbjct: 1621 -RLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLA 1679
Query: 305 EFAFEDMYNADRKVKGNLILHLEPEPLPTVTNQIQDEELDLSMEQENLGAAEDLPVTEAE 364
E + A++++ + L E E Q+ +EEL +++E A + EAE
Sbjct: 1680 EGTAQQRLAAEQEL---IRLRAETEQ-GEQQRQLLEEEL-ARLQREAAAATQKRQELEAE 1734
Query: 365 ICS--SETDVPLVMKTQ-QIPSKVLFKKLLNKIRSQKSLWTIKSMSEDESEMITTVSEIE 421
+ +E +V L K + + S+ +K +K R + + ++E+ + + E +
Sbjct: 1735 LAKVRAEMEVLLASKARAEEESRSTSEK--SKQRLEAEAGRFRELAEEAARLRALAEEAK 1792
Query: 422 SKAPTVESGTI---ASKERTLSSGQEQVVESDTLTIESGPLASEDKPLSCGTNSGKEQEI 478
+ E A ER L+ + E+ L E+ E + + E E
Sbjct: 1793 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1852
Query: 479 NETLPITTVAQSSVLLHPQEAAARIRMSA-----RQKQIME--IEEQKQKQLELL----- 526
+ + A + +E A++R ++ RQK ++E + +++Q + E+L
Sbjct: 1853 FQRRRLEEQA-AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKAS 1911
Query: 527 ---EQIEQQKLRLETDCFRAQLEEEKRKKTQPTGVGIAPASCPVISDEDSHRQMIRNYQH 583
+ +L LE R+ E+ R K Q + A +E R+ Q
Sbjct: 1912 FEKAAAGKAELELELGRIRSNAEDTLRSKEQ-AELEAARQRQLAAEEERRRREAEERVQK 1970
Query: 584 QLLQQNRLHRQSVETAR-----KQLLEYQTMLKGRCPSVSAPSLITDSVISVPSWKSERP 638
L + RQ K +E L+ R SA L + ++E
Sbjct: 1971 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK 2030
Query: 639 TAISEHWDQGQRLKLSPNKYQPI----------QPIQTSKLEQDHFQVARQNHFPQRQVE 688
+ Q L+ + + Q + + E+ Q R+ +RQVE
Sbjct: 2031 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2090
Query: 689 TTETLRASDILTNQALESQEHLRQFSQTETQQRDYKLVPKDSETLSRALSHDRQLISQDA 748
E L+ S QA + + + E +Q + + L + + D ++ +
Sbjct: 2091 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM--EKH 2148
Query: 749 RKISETFGATTFQSLESQQLFSENSENISYHLTEPSSFVPLVPQHSFSSLPVKVESGKIQ 808
+K +E Q+L + + + L E H + L +++ K +
Sbjct: 2149 KKFAE-------QTLRQKAQVEQELTTLRLQLEE--------TDHQKNLLDEELQRLKAE 2193
Query: 809 EPFSAMSKSTVSTS-HSIISQMHD----RPLLPSEN----ITAQQGNMKALQEQLDLQKK 859
+A +S V S+ QM + + + +EN + + + LQE+ + K+
Sbjct: 2194 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2253
Query: 860 VLQ-------ATQEAQEQLLLCKQKEVEQQTGLSVFLPLVTPDSSALLPSAKADLGRIQE 912
V + A QEA +L ++++ QQ L+ + K + +QE
Sbjct: 2254 VAEEAARLSVAAQEA-ARLRQLAEEDLAQQRALAEKM-------------LKEKMQAVQE 2299
Query: 913 SSPTKNNIAVSSDHHVISQLQDKRL-----SLSQPILSQQNNFKFL-----QEQLNIQKD 962
++ K + ++Q Q +RL ++Q + + F+ Q QL + +
Sbjct: 2300 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE 2359
Query: 963 SLQARREAQEVLYVHKQSELDRRVCSEQAEPSFPFQVAQHTFTSLPSADTKSGKIQEQHS 1022
+ + + E+ ++E D + +QAE T ++ +IQ Q S
Sbjct: 2360 AERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2419
Query: 1023 SKSEKGLVSCQSDI-----PISQDGSLSFLQQFLPLHDSLKLLQEQLTKQRDTLQARHEA 1077
+ L +++ + Q+ L L+ + + QEQL ++ LQ +
Sbjct: 2420 DHDAERLREAIAELEREKEKLQQEAKLLQLKS----EEMQTVQQEQLLQETQALQQSFLS 2475
Query: 1078 QVELLLHRQRDLGDSKSGLVSSSSSPVVVQHSVASQASAKAEPRRIQELYLSEKENVGPS 1137
+ + LL R+R + K+ L + Q VA + E +R Q+ E++ + S
Sbjct: 2476 EKDSLLQRERFIEQEKAKLEQ------LFQDEVAKAQQLREEQQRQQQQMEQERQRLVAS 2529
Query: 1138 CHLIIPTFQDKSLSFPQHSLAQQENLTILQEQSQIQRVIL 1177
+ + + + +QE L L++Q + Q +L
Sbjct: 2530 ----MEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2565
Score = 69.7 bits (169), Expect = 4e-11
Identities = 209/1051 (19%), Positives = 404/1051 (38%), Gaps = 170/1051 (16%)
Query: 17 EEAFILKEDYERRRKLRLLQVREQER---DIALQIREDIKQRRNQQFTRLAEE---LRAE 70
E+A + + ER +L + E R + + ++E K+ N++ RLAE+ R
Sbjct: 1800 EDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE--KEAENERLRRLAEDEAFQRRR 1857
Query: 71 WEESQTQKIQNLEKLYLASLRSMGEGH---------------RQAKENEPDLDALAQRAA 115
EE Q ++E+ LA LR + RQ +E L A ++AA
Sbjct: 1858 LEEQAAQHKADIEER-LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA 1916
Query: 116 ERKRKADLRHKEALKVQKNQKEILLKQKTWHIKA-RKEALLVEKERSAKITSLPPPPPTL 174
K + +L E +++ N ++ L ++ ++A R+ L E+ER
Sbjct: 1917 AGKAELEL---ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR------------- 1960
Query: 175 FENIEVKRISAVKTNSSTYHHLHTFVNRETDTKRPDARLAAEEEAKRLEE---------- 224
+R + + S R+ + + A EEA+RL E
Sbjct: 1961 ------RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2014
Query: 225 -LQKQAAQERMERFEKAHVRGFQAMKKIHLAQNQEKLMKELKQLQQE-DLARRRQTVAQM 282
L ++AAQ+R++ EKAH Q K+ L Q ++ L QL+ E + ARR A+
Sbjct: 2015 QLAQEAAQKRLQAEEKAHAFAVQ-QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2073
Query: 283 PPQLVELPYKRSEMKEDWQRELEFAFEDMYNADRKVKGNLILHLEPEPLPTVTNQIQDEE 342
E +S + + L+ + E+ A + + L E + Q E+
Sbjct: 2074 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA-AAEKLRKEAEQEAARRAQAEQ 2132
Query: 343 LDLSMEQ-------ENLGAAEDLPVTEAEICSSETDVPLVMKTQQIPSKVLFKKLLN--- 392
L +Q ++ AE +A++ T + L ++ +L ++L
Sbjct: 2133 AALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKA 2192
Query: 393 ------KIRSQ--KSLWTIKSMSEDESEMITTVSEIESKAPTVESGTIASKERTLSSGQE 444
+ RSQ + L++++ E+ S++ + E E++A + K+ T QE
Sbjct: 2193 EATEAARQRSQVEEELFSVRVQMEELSKLKARI-EAENRAL-----ILRDKDNTQRFLQE 2246
Query: 445 QVVESDTLTIESGPLASEDKPLSCGTNSGKEQEINETLPITTVAQSSVLLHPQEA---AA 501
+ + + E+ L+ ++ + Q E L +L +A A
Sbjct: 2247 EAEKMKQVAEEAARLS-----VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT 2301
Query: 502 RIRMSAR--QKQIMEIEEQKQKQLELLEQIEQQKLRLETDCFRAQLEEEKRKKTQPTG-- 557
R++ A Q+Q +EQ ++ E EQ+ QQ L ET F+ LE E++++ + +
Sbjct: 2302 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ-LAEETQGFQRTLEAERQRQLEMSAEA 2360
Query: 558 ----VGIAPAS-CPVISDEDSHRQMIRNYQHQLLQQNRLHRQSVETARKQLLEYQTMLKG 612
+ +A S ++ED+ R R ++ +LHR + T K L QT+
Sbjct: 2361 ERLKLRVAEMSRAQARAEEDAQR--FRKQAEEI--GEKLHRTELATQEKVTL-VQTLEIQ 2415
Query: 613 RCPSVSAPSLITDSVISVPSWKS--ERPTAISEHWDQGQRLKLSPNKYQPIQPIQTSKLE 670
R S + +++ + K ++ + + + + Q Q +Q S L
Sbjct: 2416 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2475
Query: 671 QDHFQVARQNHFPQRQVETTETLRASDILTNQALESQEHLRQFSQTETQQ-----RDYKL 725
+ + R+ Q + + + + Q E Q+ +Q + E Q+ + +
Sbjct: 2476 EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2535
Query: 726 VPKDSETLSRALSHDRQLISQDARKISETFGATTFQSLESQQLFSE-------NSENISY 778
++E R + Q + Q R+ E + E QL E +SE ++
Sbjct: 2536 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2595
Query: 779 HLTEPSSFVP------------LVPQHSFSSLPVKVESGKIQEP--FSAMSKSTVSTSHS 824
+ +P P+HSF L KV + ++QE SA ++ H+
Sbjct: 2596 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2655
Query: 825 IISQMHDRPLLPSENITAQQGNMKALQEQLDLQKKVLQATQEAQEQLLLCKQKEVEQQTG 884
+ ++ R + LQ + + +L+AT E L +++Q
Sbjct: 2656 TVDELARR-----------EDVRHYLQGRSSIAGLLLKATNEK-----LSVYAALQRQ-- 2697
Query: 885 LSVFLPLVTPDSSALLPSAKADLG---------RIQESSPTKNNIAVSSDHHVISQLQDK 935
L++P ++ +L A+A G R+ + K + HH + +
Sbjct: 2698 ------LLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERA 2751
Query: 936 RLSLSQPILSQQ-NNFKFLQEQLNIQKDSLQ 965
P QQ + F+ +Q+ L +++ ++
Sbjct: 2752 VTGYKDPYTGQQISLFQAMQKGLIVREHGIR 2782
Score = 66.2 bits (160), Expect = 4e-10
Identities = 325/1784 (18%), Positives = 662/1784 (37%), Gaps = 255/1784 (14%)
Query: 50 EDIKQRRNQQFTRLAEELRAEWEESQT----QKIQNLEKLYLASLRSMGEGHRQAKENEP 105
+DI+ + TR LR ++ Q+I +K A + +G+G +
Sbjct: 968 KDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQ-AEVEGLGKGVARLSAEAE 1026
Query: 106 DLDALAQ---RAAERKRKADLRHKEALKVQKNQKEILLKQKTWHIKAR-----KEALLVE 157
+ AL + A + + +L + +V+ L K KT + R +E L
Sbjct: 1027 KVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH 1086
Query: 158 KERSAKITSLPPPPPTLFENIEVKRISAVKTNSSTYHHLHTFVNRETDTKRPDARLAAEE 217
+E+ + ++P P L E + S K + TF D R + R A+E
Sbjct: 1087 EEQLKEAQAVPATLPEL----EATKASLKKLRAQAEAQQPTF-----DALRDELR-GAQE 1136
Query: 218 EAKRLEEL--QKQAAQERM-ERFEKAHVRGFQAMKKIHLAQNQ-EKLMKELKQLQQ---- 269
+RL++ ++ ER ER + R + + + Q + E+L ++L+ ++
Sbjct: 1137 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADP 1196
Query: 270 -----EDLARRRQTVAQMPPQLVELPYKRSEMKEDWQ--RELEFAFEDMYNADRKVKGNL 322
+D RR++ + MP L + R +++++ E+E E + R K
Sbjct: 1197 LGAWLQDARRRQEQIQAMP--LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAK-QY 1253
Query: 323 ILHLEPEPLPTVTNQIQDEELDLSMEQENLGAAEDLPVTEAEICSSETDVPLVMKTQQIP 382
I ++ L VT + Q E + ++ + + + + E + + +Q I
Sbjct: 1254 INAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK 1313
Query: 383 SKVLFKKLLNKIRSQKSLWTIKSMSEDESEMITTVSEIESKAPTVESGTIASKERTLSSG 442
+ L ++ ++ L + +E+ + + +E + E+ A + +
Sbjct: 1314 ---FISETLRRMEEEERL-AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK 1369
Query: 443 ------QEQVVESDTLTIESGPLASEDKPLSCGTNSGKEQEINETLPITTVAQSSVLLHP 496
QE+VV + +++ + E EI A+ S L
Sbjct: 1370 ELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1429
Query: 497 QEA-AARIRMSARQKQIMEIEEQKQKQLELLEQIEQQKLRL--ETDCFRAQLEEEKRKKT 553
+E R+++ A ++Q E + Q E+ E QK + E + R Q+++E ++K
Sbjct: 1430 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR 1489
Query: 554 QPTGVGIAPASCPVISDEDSHRQMIRNYQHQLLQQNRLHRQSVETARKQLLEYQTMLKGR 613
Q A + S + + R Q L L Q+ E R+ L + + R
Sbjct: 1490 Q--------AEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR--LRQAEVERAR 1539
Query: 614 CPSVSAPSLITDSVISVPSWKSERPTAISEHWDQGQRLKLSPNKYQPIQPIQTSKLEQDH 673
V+ + + + S ++ + +E Q +R L+++H
Sbjct: 1540 QVQVALETAQRSAEAELQSKRA----SFAEKTAQLER-----------------SLQEEH 1578
Query: 674 FQVARQNHFPQRQVET-TETLRASDI----LTNQALESQEHLRQFSQTETQQRDYKLVPK 728
VA+ +R+ + E RA + L L++ E LR Q E + L
Sbjct: 1579 VAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQA 1638
Query: 729 DSETLSRALSHDRQLISQDARKISETFGATTFQSLESQQLFSENSENISYHLTEPSSFVP 788
++E ++A + + G Q++ ++L + E L E ++
Sbjct: 1639 EAEKQK-----------EEAEREARRRGKAEEQAVRQRELAEQELEK-QRQLAEGTAQQR 1686
Query: 789 LVPQHSFSSLPVKVESGKIQEPFSAMSKSTVSTSHSIISQMHDRPLLPSENITAQQGNMK 848
L + L + E G+ Q R LL E Q+
Sbjct: 1687 LAAEQELIRLRAETEQGEQQ-----------------------RQLLEEELARLQREAAA 1723
Query: 849 ALQEQLDLQKKVLQATQEAQEQLLLCKQKEVEQQTGLSVFLPLVTPDSSALLPSAKADLG 908
A Q++ +L+ ++ A A+ ++LL + E+++ + S +A+ G
Sbjct: 1724 ATQKRQELEAEL--AKVRAEMEVLLASKARAEEESRST---------SEKSKQRLEAEAG 1772
Query: 909 RIQESSPTKNNIAVSSDHHVISQLQDKRLSLSQPILSQQNNFKFLQEQLNIQKDSLQARR 968
R +E + + ++ + ++L+ + + L E+L ++ + +
Sbjct: 1773 RFRELAEEAARLRALAEE----AKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT 1828
Query: 969 EAQEVLYVHKQSELDR--RVCSEQA--EPSFPFQVAQHTFTSLPSADTKSGKIQEQHSSK 1024
EA E+ K++E +R R+ ++A Q AQH AD + Q + +S
Sbjct: 1829 EA-EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH------KADIEERLAQLRKASD 1881
Query: 1025 SE----KGLV--SCQSDIPISQDGSLSFLQQFLPLHDSLKLLQEQLTKQR----DTLQAR 1074
SE KGLV + + + ++ L+ F L+ +L + R DTL+++
Sbjct: 1882 SELERQKGLVEDTLRQRRQVEEE-ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSK 1940
Query: 1075 HEAQVELLLHRQRDLGDSKSGLVSSSSSPVVVQHSVASQASAKAEPRRIQELYLSEKENV 1134
+A++E RQ + + + VQ S+A++ A + + E K V
Sbjct: 1941 EQAELEAARQRQLAAEEERRRREAEER----VQKSLAAEEEAARQRKAALEEVERLKAKV 1996
Query: 1135 GPSCHLIIPTFQD--KSLSFPQ-------------HSLAQQENLTILQEQSQIQRVILGA 1179
+ L Q+ + L Q H+ A Q+ LQ+ Q ++ +L
Sbjct: 1997 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2056
Query: 1180 KEGTQEFVHTESEL--EKRISSEQTGTSSSLSQVDESERFQECISIKSDSTIPLSHPKIP 1237
G E +E E R+ +E+ S QV+E+ER ++ ++ +
Sbjct: 2057 LRGEAEAARRAAEEAEEARVQAEREAAQSR-RQVEEAERLKQSAEEQAQARAQAQAAAEK 2115
Query: 1238 RCQERLLRVSQHMLPLQDNLEEHQAW-LDTEKEAFHFSQKTQENTSSEQTGSSSFIPQLV 1296
+E ++ Q L + QA + EK Q ++ EQ +L
Sbjct: 2116 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ--------ELT 2167
Query: 1297 QLSFTSLASAESGTILEPLFTESESKIFSSHLQIPQLQDRLLRISQLIQPQQDNLKALQE 1356
L + +L+ +++ + Q Q+++ L + + Q + L L+
Sbjct: 2168 TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV----RVQMEELSKLKA 2223
Query: 1357 QLATQREAIILARQEAREELLLHQSEWEGRISPEQVDTSSLPLVPQHSFASLPLNESERN 1416
++ + A+IL ++ + L ++E +++ E + L + Q + L E +
Sbjct: 2224 RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE---AARLSVAAQEAARLRQLAEEDLA 2280
Query: 1417 QEPCSINSDNIVSSGHSEIPTLPDGLLGLSHLVLPQQDNLIALEEHLHAQTDFLPSIEKT 1476
Q+ L+ +L ++ + L A+ + L +
Sbjct: 2281 QQRA------------------------LAEKMLKEKMQAVQEATRLKAEAELL----QQ 2312
Query: 1477 QKELVLSKPCKFEEKVSSEHFIQSHHGDLQALQQQLDTQKKAIRSIQEVQEELLLQRLSE 1536
QKEL + + +E E Q + Q Q+ L+ +++ + E L L R++E
Sbjct: 2313 QKELAQEQARRLQE--DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL-RVAE 2369
Query: 1537 LEKRVSSEQVCSSSFVSQVPVADSERTQKSFPTKSNDTL--------PSSHREIPRLQDR 1588
+ + + + + F Q + + T+ TL S + RL++
Sbjct: 2370 MSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA 2429
Query: 1589 LLSLSKPILP-QQDNMTAQLDAQREVMYSYEKPQEELSLNKQRKLNKSESAEHTIPSLFL 1647
+ L + QQ+ QL ++ E+ +E +Q L++ +S F+
Sbjct: 2430 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR--ERFI 2487
Query: 1648 PKETEHSFIPLPFAEAKPKSTCELYSSQNEHAAPPSNPVIPGFQD---RLLSFSQSVLTQ 1704
+E AK + E Q + ++ ++ R + V +
Sbjct: 2488 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2547
Query: 1705 QDNLGLQKQLDLQREVLHYSQKAQEKLLVQRQTALQQQIQKHEE 1748
Q+ L +QL+ QR + QE+LL + L++Q+Q EE
Sbjct: 2548 QEEL---QQLEQQR-------RQQEELLAEENQRLREQLQLLEE 2581
Score = 65.5 bits (158), Expect = 7e-10
Identities = 317/1778 (17%), Positives = 637/1778 (35%), Gaps = 269/1778 (15%)
Query: 228 QAAQERMERFEKAHVRGFQAMKKIHLAQNQ----EKLMKELKQLQQEDLARRRQTVAQMP 283
Q AQE + R E H ++H+ + L ++++ ++ LA R +
Sbjct: 841 QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQ 900
Query: 284 PQLV---ELPYKRSEMKEDWQRELEFAFEDMYNADRKVKGNLILHLEPEPLPTVTNQIQD 340
Q + EL Y+ D Q F ED A+R+ G+ H + + L ++ Q+
Sbjct: 901 RQALHSLELHYQA--FLRDSQDAGGFGPEDRLMAEREY-GSCSHHYQ-QLLQSLEQGAQE 956
Query: 341 EELDLSMEQENLGAAEDLPVTEAEICSSETDVPLVMKTQQIPSKVLFKKLLNKIRSQ--- 397
E S Q + +D+ + + E C + T L + + P++ +++ + ++Q
Sbjct: 957 E----SRCQRCISELKDIRL-QLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEV 1011
Query: 398 KSLWTIKSMSEDESEMITTVSEIESKAPTVESG---TIASKERTLSSGQEQVVESDTLTI 454
+ L + E+E + + E APT+ S T+ E+ S + + T+++
Sbjct: 1012 EGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISL 1071
Query: 455 ESGPLASEDKPLSCGTNSGKE-QEINETLPITTVAQSSV--------------------L 493
++ L KE Q + TLP ++S+ L
Sbjct: 1072 VIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDEL 1131
Query: 494 LHPQEAAARIRMSARQKQIMEIEEQKQKQLELLEQIEQQKLRLETDCFRAQLEE------ 547
QE R++ ++ + E+E +++ +LLE+ Q + +TD + +LE+
Sbjct: 1132 RGAQEVGERLQQRHGERDV-EVERWRERVAQLLER--WQAVLAQTDVRQRELEQLGRQLR 1188
Query: 548 EKRKKTQPTGVGIAPA-------SCPVISDEDSHRQMIRNYQHQLLQQNRLHRQSVETAR 600
R+ P G + A ++D + R+ +R Q LL++ H + VE +
Sbjct: 1189 YYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQ-ALLEEIERHGEKVEECQ 1247
Query: 601 KQLLEYQTMLKG---RCPSVSAPSLITDSVISVPSWKSERPTAISEHWD-QGQRLKLSPN 656
+ +Y +K + + A S P +S + I E+ D + +L+
Sbjct: 1248 RFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTL 1307
Query: 657 KYQPIQPI-QTSKLEQDHFQVARQNHFPQRQ--VETTETLRASDILTN-------QALES 706
Q I+ I +T + ++ ++A Q +R+ E L L QA
Sbjct: 1308 TSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAERE 1367
Query: 707 QEHLRQFSQTETQQRDYKLVPKDSETLSRALSHDRQLISQDARKISETFGATTFQSLESQ 766
+ L+Q Q E +R+ V D++ R++ + Q + Q + + A ++ E
Sbjct: 1368 AKELQQRMQEEVVRREEAAV--DAQQQKRSIQEELQQLRQSSEAEIQA-KARQAEAAERS 1424
Query: 767 QLFSENSENISYHLTEPSSFVPLVPQHSFSSLPVKVESGKIQEPFSAMSKSTVSTSHSII 826
+L E + E + + +L + E + Q+ + + +
Sbjct: 1425 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK------RQAQEEAERLR 1478
Query: 827 SQMHDRPLLPSENITAQQGNMKALQEQLDLQKKVLQATQE----AQEQLLLCKQKEVEQQ 882
Q+ D + +KA E +++ LQA +E A+E +Q EVE+
Sbjct: 1479 RQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1538
Query: 883 TGLSVFLPLVTPDSSALLPSAKADLGRIQESSPTKNNIAVSSDHHVISQLQDK------- 935
+ V L + A L S +A + ++ +H ++QL+++
Sbjct: 1539 RQVQVALETAQRSAEAELQSKRASFAE----KTAQLERSLQEEHVAVAQLREEAERRAQQ 1594
Query: 936 --------------------------RLSLSQPILSQQNNFKFLQEQLNIQKDSLQARRE 969
RL L ++QQ + + + ++ +ARR
Sbjct: 1595 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1654
Query: 970 AQEVLYVHKQSELDRRVCSEQ---AEPSFPFQVAQHTFTSLPSADTKSGKIQEQHSSKSE 1026
+ +Q EL + +Q AE + ++A A+T+ G EQ E
Sbjct: 1655 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG---EQQRQLLE 1711
Query: 1027 KGLVSCQSDIPISQDGSLSFLQQFLPLHDSLKLLQEQLTKQRDTLQARHEA---QVELLL 1083
+ L Q + + + + +++L + + ++ E ++E
Sbjct: 1712 EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA 1771
Query: 1084 HRQRDLGDSKSGLVS---------------SSSSPVVVQHSVASQASAKAEPRRIQ---E 1125
R R+L + + L + ++ + +A + +A E R++ E
Sbjct: 1772 GRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE 1831
Query: 1126 LYLSEKENVGPSCHLIIP--TFQDKSLS--FPQHSLAQQENLTILQEQS----------- 1170
+ L EKE + FQ + L QH +E L L++ S
Sbjct: 1832 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV 1891
Query: 1171 --------QIQRVILGAKEGTQEFVHTESELEK---RISSEQTGTSSSLSQVD------- 1212
Q++ IL K ++ ++ELE RI S T S Q +
Sbjct: 1892 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1951
Query: 1213 ------------ESERFQECISIKSDST------------IPLSHPKIPRCQERLLRVSQ 1248
ER Q+ ++ + ++ + + R +ER + S
Sbjct: 1952 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2011
Query: 1249 HMLPLQDNLEEHQAWLDTEKEAFHFSQKTQENTSSEQTGSSSFIPQLVQLSFTSLASAES 1308
L L + + + + AF QK QE + Q S L QL + A+ +
Sbjct: 2012 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV----LDQLRGEAEAARRA 2067
Query: 1309 GTILEPLFTESESKIFSSHLQIPQLQDRLLRISQLIQPQQDNLKALQEQLATQREAIILA 1368
E ++E + S Q+ + + RL + ++ + +A E+L + E
Sbjct: 2068 AEEAEEARVQAEREAAQSRRQVEEAE-RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2126
Query: 1369 RQEAREELLLHQSEWEGRISPEQVDTSSLPLVPQHSFASLPLNESERNQEPCSINSDNIV 1428
R +A + L Q + + FA L + + ++ + +
Sbjct: 2127 RAQAEQAAL------------RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2174
Query: 1429 SSGHS------EIPTLPDGLLGLSHLVLPQQDNLIALEEHLHAQTDFLPSIEKTQKELVL 1482
+ H E+ L + ++ L ++ + + IE + L+L
Sbjct: 2175 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2234
Query: 1483 SKPCKFEEKVSSEHFIQSHHGDLQALQQQLDTQKKAIRSIQEVQEELLLQRLSELEKRVS 1542
+K +++ F+Q + ++ ++A R QE L++L+E + ++
Sbjct: 2235 ------RDKDNTQRFLQ------EEAEKMKQVAEEAARLSVAAQEAARLRQLAEED--LA 2280
Query: 1543 SEQVCSSSFVSQVPVADSERTQKSFPTKSNDTLPSSHREIPRLQDRLLSLSKPILPQQ-- 1600
++ + + + A E T+ K+ L +E+ + Q R L K + QQ
Sbjct: 2281 QQRALAEKMLKEKMQAVQEATR----LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2336
Query: 1601 ---DNMTAQLDAQREVMYSYEKPQEELSLNKQRKLNKSESAEHTIPSLFLPKETEHSFIP 1657
L+A+R+ E L L AE K+ E
Sbjct: 2337 EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF--RKQAEEIGEK 2394
Query: 1658 LPFAEAKPKS------TCELYSSQNEHAAPPSNPVIPGFQDRLLSFSQS-----VLTQQD 1706
L E + T E+ Q++H A I + Q + +++
Sbjct: 2395 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2454
Query: 1707 NLGLQKQLDLQREVLHYSQKAQEKLLVQRQTALQQQIQKHEETLKDFFKDSQISKPTVEN 1766
Q+QL + + L S +++ L+QR+ ++Q+ K E+ +D +Q + E
Sbjct: 2455 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE--EQ 2512
Query: 1767 DLKTQKMGQLRDWFPNTQDLAGNDQENIRHADRNNSDD 1804
+ Q+M Q R + + A Q R ++
Sbjct: 2513 QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE 2550
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 73.9 bits (180), Expect = 2e-12
Identities = 305/1563 (19%), Positives = 588/1563 (37%), Gaps = 252/1563 (16%)
Query: 35 LQVREQERDIALQIREDIKQRRNQQFTRLAEELRAEWEESQTQKIQNLEKLYLASLRSMG 94
LQ R ERD+ ++ R ++ +L E +A ++ ++ + L +G
Sbjct: 1149 LQQRHGERDVEVE-------RWRERVAQLLERWQAVLAQTDVRQRE---------LEQLG 1192
Query: 95 EGHRQAKENEPDLDALAQRAAERKRKAD---LRHKEALKVQKNQKEILLKQKTWHIKARK 151
R +E+ L A Q A R+ + L +A++ Q Q++ LL++ H + +
Sbjct: 1193 RQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVE 1252
Query: 152 EALLVEKERSAKITSLPPPPPTLFENIEVKRISAVKTNSST--------YHHLHTFVNRE 203
E K+ I T +E A K + Y L T +
Sbjct: 1253 ECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSEL 1312
Query: 204 TDTKRPDARLAAE-----EEAKRLEELQKQAAQERMERFEKAHVRGFQAMKKIHLAQNQ- 257
T + +E EE +RL E Q+ +ER+ E A + Q + A+ Q
Sbjct: 1313 TTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQA 1372
Query: 258 EKLMKELKQLQQEDLARRRQTVAQMPPQLVELPYKRSEMKEDWQRELEFAFEDMYNADR- 316
E+ KEL+Q QE++ RR + Q + + ++++ + E++ A+R
Sbjct: 1373 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS 1432
Query: 317 --KVKGNL-ILHLEPEPLPTVTNQIQDEELDLSMEQENLGAAEDLPVTEAEICSSETDVP 373
+++ + ++ L+ E + E L E A + EAE +
Sbjct: 1433 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1492
Query: 374 LVMKTQ---QIPSKVL--FKKLLNKIRSQKSLWTIKSMSED------------------- 409
K Q ++ S+V + K R+ ++L ++ +E+
Sbjct: 1493 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1552
Query: 410 -ESEMITTVSEIESKAPTVESGTIASKERTLSSGQEQVVESDTLTIESGPLASEDKPLSC 468
E+ + +E++SK + T A ER+L QE+ V L E+ A +
Sbjct: 1553 LETAQRSAEAELQSKRASFAEKT-AQLERSL---QEEHVAVAQLREEAERRAQQQAEAER 1608
Query: 469 GTNSGKEQ------EINETLPI----------TTVAQSSVLLHPQEAAARIR-------M 505
+ + + NE L + ++AQ+ +EA R
Sbjct: 1609 AREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQ 1668
Query: 506 SARQKQIMEIEEQKQKQL-------------ELL------EQIEQQKLRLETDCFRAQLE 546
+ RQ+++ E E +KQ+QL EL+ EQ EQQ+ LE + R Q E
Sbjct: 1669 AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1728
Query: 547 ----EEKRKKTQPTGVGIAPASCPVI------SDEDSHRQMIRNYQHQLLQQNRLHRQSV 596
+KR++ + + A V+ ++E+S ++ Q + R +
Sbjct: 1729 AAAATQKRQELE-AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1787
Query: 597 ETARKQLLEYQTMLKGRCPS-------VSAPSLITDSVISV---PSWKSERPTAISEHWD 646
E AR + L + + + A ++ + + ++ K+E A+ E
Sbjct: 1788 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1847
Query: 647 QGQRLKLSPNKYQPIQPIQTSKLEQDHFQVARQNHFPQRQVETTETLRASDI-LTNQALE 705
+ +RL+ + + Q +LE+ Q H + + +ASD L Q
Sbjct: 1848 ENERLR----RLAEDEAFQRRRLEEQAAQ-----HKADIEERLAQLRKASDSELERQKGL 1898
Query: 706 SQEHLRQFSQTETQQRDYKLVPKDSETLSRALSHDRQLISQDARKISETFGATTFQSLES 765
++ LRQ Q E + K + + L + I +A + ++
Sbjct: 1899 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1958
Query: 766 QQLFSENSENISYHLTEPSSFVPLVPQHSFSSLPVKVESGKIQEPFSAMSKSTVSTSHSI 825
+QL +E E V Q S ++ +E + K+ + +
Sbjct: 1959 RQLAAEEER----RRREAEERV----QKSLAA----------EEEAARQRKAALEEVERL 2000
Query: 826 ISQMHDRPLLPSENITAQQGNMKALQEQLDLQKKVLQATQEAQEQLLLCKQKEVEQ--QT 883
+++ + L A+Q + + LQ + +K LQA ++A + K++E++Q Q
Sbjct: 2001 KAKVEEARRLRER---AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2057
Query: 884 GLSVFLPLVTPDSSALLPSAKADLGRIQ-ESSPTKNNIAVSSDHHVISQLQDKRLSLSQP 942
SV L +A + +A+ R+Q E ++ V + +++ + +Q
Sbjct: 2058 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQA 2117
Query: 943 ILSQQNNFKFLQEQLNIQKDSLQARR-EAQEVLYVHKQ---SELDRRVCSEQAEPSFPFQ 998
+ E+L + + ARR +A++ KQ +E+++ + Q
Sbjct: 2118 --------QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQ 2169
Query: 999 VAQHTFT---SLPSADTKSGKIQEQHSSKSEKGLVSCQSDIPISQDGSLSFLQQFLPLHD 1055
V Q T L D + + E+ + + + + ++
Sbjct: 2170 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE------------LF 2217
Query: 1056 SLKLLQEQLTKQRDTLQARHEAQVELLLHRQRDLGD---SKSGLVSSSSSPVVVQHSVAS 1112
S+++ E+L+K L+AR EA+ L+ R +D + + + SVA+
Sbjct: 2218 SVRVQMEELSK----LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2273
Query: 1113 QASAK---------AEPRRIQELYLSEK-ENVGPSCHLIIPTFQDKSLSFPQHSLAQQEN 1162
Q +A+ A+ R + E L EK + V + L + L Q LAQ++
Sbjct: 2274 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL----KAEAELLQQQKELAQEQA 2329
Query: 1163 LTILQEQSQIQRVILGAKEGTQEFVHTESELEKRISSEQTGTSSSLSQV--------DES 1214
+ +++ Q+ + + +G Q + E + + +S+E ++++ +++
Sbjct: 2330 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2389
Query: 1215 ERFQ---ECISIKSDSTIPLSHPKIPRCQ--ERLLRVSQHMLPLQDNLEEHQAWLDTEKE 1269
+RF+ E I K T + K+ Q E + S H + L E A L+ EKE
Sbjct: 2390 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD---AERLREAIAELEREKE 2446
Query: 1270 AFHFSQKTQENTSSE-QTGSSSFIPQLVQLSFTSLASAESGTILEPLFTESESKIFSSHL 1328
K + S E QT + Q Q S S + + F E E
Sbjct: 2447 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK------A 2500
Query: 1329 QIPQL-QDRLLRISQLIQPQQDNLKALQEQLATQREAIILARQEAREELLLHQSEWEGRI 1387
++ QL QD + + QL + QQ Q+Q+ +R+ ++ + +EAR Q E E +
Sbjct: 2501 KLEQLFQDEVAKAQQLREEQQRQ----QQQMEQERQRLVASMEEARR----RQHEAEEGV 2552
Query: 1388 SPEQVDTSSLP---------LVPQHSFASLPLNESERNQEPCSINSDNIVSSGHSEIPTL 1438
+Q + L L ++ L E +S+ + +S + TL
Sbjct: 2553 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTL 2612
Query: 1439 PDG 1441
P+G
Sbjct: 2613 PNG 2615
Score = 73.6 bits (179), Expect = 2e-12
Identities = 238/1240 (19%), Positives = 472/1240 (38%), Gaps = 148/1240 (11%)
Query: 10 KLRLSPNEEAFILKEDYERRRKLRLLQVREQERDIALQIREDIKQRRNQQFTRLAEELRA 69
+LR S E E + RL ++ E+ R + LQ+ +QR + A RA
Sbjct: 1410 QLRQSSEAEIQAKARQAEAAERSRL-RIEEEIRVVRLQLEATERQRGGAEGELQALRARA 1468
Query: 70 EWEESQTQKIQNLEKLYLASLRSMGEGHRQAKENEPDLDALAQRAAERKRKADLRHKEAL 129
E E+Q ++ Q + ++ + RQA E E A+ A R+++ L+ E L
Sbjct: 1469 EEAEAQKRQAQEEAERLRRQVQDESQRKRQA-EVELASRVKAEAEAAREKQRALQALEEL 1527
Query: 130 KVQKNQKEILLKQKTWHIKARKEALLVEKERSAKITSLPPPPPTLFENIEVKRISAVKTN 189
++Q + E L+Q + + L +RSA+ ++ KR S +
Sbjct: 1528 RLQAEEAERRLRQAEVERARQVQVALETAQRSAE------------AELQSKRASFAEKT 1575
Query: 190 SSTYHHLHTFVNRETDTKRPDARLAAEEEAKRLEELQKQAAQERMER-FEKAHVRGFQAM 248
+ L + A+L E E + ++ + + A+E ER E+ ++ +A+
Sbjct: 1576 AQLERSLQ-------EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1628
Query: 249 KKIHLAQNQEKLMKELKQLQQEDLARRRQTVAQMPPQLVELPYKRSEMKE---DWQREL- 304
++ L + K L Q + E + A+ + E ++ E+ E + QR+L
Sbjct: 1629 -RLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLA 1687
Query: 305 EFAFEDMYNADRKVKGNLILHLEPEPLPTVTNQIQDEELDLSMEQENLGAAEDLPVTEAE 364
E + A++++ + L E E Q+ +EEL +++E A + EAE
Sbjct: 1688 EGTAQQRLAAEQEL---IRLRAETEQ-GEQQRQLLEEEL-ARLQREAAAATQKRQELEAE 1742
Query: 365 ICS--SETDVPLVMKTQ-QIPSKVLFKKLLNKIRSQKSLWTIKSMSEDESEMITTVSEIE 421
+ +E +V L K + + S+ +K +K R + + ++E+ + + E +
Sbjct: 1743 LAKVRAEMEVLLASKARAEEESRSTSEK--SKQRLEAEAGRFRELAEEAARLRALAEEAK 1800
Query: 422 SKAPTVESGTI---ASKERTLSSGQEQVVESDTLTIESGPLASEDKPLSCGTNSGKEQEI 478
+ E A ER L+ + E+ L E+ E + + E E
Sbjct: 1801 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1860
Query: 479 NETLPITTVAQSSVLLHPQEAAARIRMSA-----RQKQIME--IEEQKQKQLELL----- 526
+ + A + +E A++R ++ RQK ++E + +++Q + E+L
Sbjct: 1861 FQRRRLEEQA-AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKAS 1919
Query: 527 ---EQIEQQKLRLETDCFRAQLEEEKRKKTQPTGVGIAPASCPVISDEDSHRQMIRNYQH 583
+ +L LE R+ E+ R K Q + A +E R+ Q
Sbjct: 1920 FEKAAAGKAELELELGRIRSNAEDTLRSKEQ-AELEAARQRQLAAEEERRRREAEERVQK 1978
Query: 584 QLLQQNRLHRQSVETAR-----KQLLEYQTMLKGRCPSVSAPSLITDSVISVPSWKSERP 638
L + RQ K +E L+ R SA L + ++E
Sbjct: 1979 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK 2038
Query: 639 TAISEHWDQGQRLKLSPNKYQPI----------QPIQTSKLEQDHFQVARQNHFPQRQVE 688
+ Q L+ + + Q + + E+ Q R+ +RQVE
Sbjct: 2039 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2098
Query: 689 TTETLRASDILTNQALESQEHLRQFSQTETQQRDYKLVPKDSETLSRALSHDRQLISQDA 748
E L+ S QA + + + E +Q + + L + + D ++ +
Sbjct: 2099 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM--EKH 2156
Query: 749 RKISETFGATTFQSLESQQLFSENSENISYHLTEPSSFVPLVPQHSFSSLPVKVESGKIQ 808
+K +E Q+L + + + L E H + L +++ K +
Sbjct: 2157 KKFAE-------QTLRQKAQVEQELTTLRLQLEE--------TDHQKNLLDEELQRLKAE 2201
Query: 809 EPFSAMSKSTVSTS-HSIISQMHD----RPLLPSEN----ITAQQGNMKALQEQLDLQKK 859
+A +S V S+ QM + + + +EN + + + LQE+ + K+
Sbjct: 2202 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2261
Query: 860 VLQ-------ATQEAQEQLLLCKQKEVEQQTGLSVFLPLVTPDSSALLPSAKADLGRIQE 912
V + A QEA +L ++++ QQ L+ + K + +QE
Sbjct: 2262 VAEEAARLSVAAQEA-ARLRQLAEEDLAQQRALAEKM-------------LKEKMQAVQE 2307
Query: 913 SSPTKNNIAVSSDHHVISQLQDKRL-----SLSQPILSQQNNFKFL-----QEQLNIQKD 962
++ K + ++Q Q +RL ++Q + + F+ Q QL + +
Sbjct: 2308 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE 2367
Query: 963 SLQARREAQEVLYVHKQSELDRRVCSEQAEPSFPFQVAQHTFTSLPSADTKSGKIQEQHS 1022
+ + + E+ ++E D + +QAE T ++ +IQ Q S
Sbjct: 2368 AERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2427
Query: 1023 SKSEKGLVSCQSDI-----PISQDGSLSFLQQFLPLHDSLKLLQEQLTKQRDTLQARHEA 1077
+ L +++ + Q+ L L+ + + QEQL ++ LQ +
Sbjct: 2428 DHDAERLREAIAELEREKEKLQQEAKLLQLKS----EEMQTVQQEQLLQETQALQQSFLS 2483
Query: 1078 QVELLLHRQRDLGDSKSGLVSSSSSPVVVQHSVASQASAKAEPRRIQELYLSEKENVGPS 1137
+ + LL R+R + K+ L + Q VA + E +R Q+ E++ + S
Sbjct: 2484 EKDSLLQRERFIEQEKAKLEQ------LFQDEVAKAQQLREEQQRQQQQMEQERQRLVAS 2537
Query: 1138 CHLIIPTFQDKSLSFPQHSLAQQENLTILQEQSQIQRVIL 1177
+ + + + +QE L L++Q + Q +L
Sbjct: 2538 ----MEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2573
Score = 69.7 bits (169), Expect = 4e-11
Identities = 209/1051 (19%), Positives = 404/1051 (38%), Gaps = 170/1051 (16%)
Query: 17 EEAFILKEDYERRRKLRLLQVREQER---DIALQIREDIKQRRNQQFTRLAEE---LRAE 70
E+A + + ER +L + E R + + ++E K+ N++ RLAE+ R
Sbjct: 1808 EDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE--KEAENERLRRLAEDEAFQRRR 1865
Query: 71 WEESQTQKIQNLEKLYLASLRSMGEGH---------------RQAKENEPDLDALAQRAA 115
EE Q ++E+ LA LR + RQ +E L A ++AA
Sbjct: 1866 LEEQAAQHKADIEER-LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA 1924
Query: 116 ERKRKADLRHKEALKVQKNQKEILLKQKTWHIKA-RKEALLVEKERSAKITSLPPPPPTL 174
K + +L E +++ N ++ L ++ ++A R+ L E+ER
Sbjct: 1925 AGKAELEL---ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR------------- 1968
Query: 175 FENIEVKRISAVKTNSSTYHHLHTFVNRETDTKRPDARLAAEEEAKRLEE---------- 224
+R + + S R+ + + A EEA+RL E
Sbjct: 1969 ------RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2022
Query: 225 -LQKQAAQERMERFEKAHVRGFQAMKKIHLAQNQEKLMKELKQLQQE-DLARRRQTVAQM 282
L ++AAQ+R++ EKAH Q K+ L Q ++ L QL+ E + ARR A+
Sbjct: 2023 QLAQEAAQKRLQAEEKAHAFAVQ-QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2081
Query: 283 PPQLVELPYKRSEMKEDWQRELEFAFEDMYNADRKVKGNLILHLEPEPLPTVTNQIQDEE 342
E +S + + L+ + E+ A + + L E + Q E+
Sbjct: 2082 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA-AAEKLRKEAEQEAARRAQAEQ 2140
Query: 343 LDLSMEQ-------ENLGAAEDLPVTEAEICSSETDVPLVMKTQQIPSKVLFKKLLN--- 392
L +Q ++ AE +A++ T + L ++ +L ++L
Sbjct: 2141 AALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKA 2200
Query: 393 ------KIRSQ--KSLWTIKSMSEDESEMITTVSEIESKAPTVESGTIASKERTLSSGQE 444
+ RSQ + L++++ E+ S++ + E E++A + K+ T QE
Sbjct: 2201 EATEAARQRSQVEEELFSVRVQMEELSKLKARI-EAENRAL-----ILRDKDNTQRFLQE 2254
Query: 445 QVVESDTLTIESGPLASEDKPLSCGTNSGKEQEINETLPITTVAQSSVLLHPQEA---AA 501
+ + + E+ L+ ++ + Q E L +L +A A
Sbjct: 2255 EAEKMKQVAEEAARLS-----VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT 2309
Query: 502 RIRMSAR--QKQIMEIEEQKQKQLELLEQIEQQKLRLETDCFRAQLEEEKRKKTQPTG-- 557
R++ A Q+Q +EQ ++ E EQ+ QQ L ET F+ LE E++++ + +
Sbjct: 2310 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ-LAEETQGFQRTLEAERQRQLEMSAEA 2368
Query: 558 ----VGIAPAS-CPVISDEDSHRQMIRNYQHQLLQQNRLHRQSVETARKQLLEYQTMLKG 612
+ +A S ++ED+ R R ++ +LHR + T K L QT+
Sbjct: 2369 ERLKLRVAEMSRAQARAEEDAQR--FRKQAEEI--GEKLHRTELATQEKVTL-VQTLEIQ 2423
Query: 613 RCPSVSAPSLITDSVISVPSWKS--ERPTAISEHWDQGQRLKLSPNKYQPIQPIQTSKLE 670
R S + +++ + K ++ + + + + Q Q +Q S L
Sbjct: 2424 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2483
Query: 671 QDHFQVARQNHFPQRQVETTETLRASDILTNQALESQEHLRQFSQTETQQ-----RDYKL 725
+ + R+ Q + + + + Q E Q+ +Q + E Q+ + +
Sbjct: 2484 EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2543
Query: 726 VPKDSETLSRALSHDRQLISQDARKISETFGATTFQSLESQQLFSE-------NSENISY 778
++E R + Q + Q R+ E + E QL E +SE ++
Sbjct: 2544 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2603
Query: 779 HLTEPSSFVP------------LVPQHSFSSLPVKVESGKIQEP--FSAMSKSTVSTSHS 824
+ +P P+HSF L KV + ++QE SA ++ H+
Sbjct: 2604 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2663
Query: 825 IISQMHDRPLLPSENITAQQGNMKALQEQLDLQKKVLQATQEAQEQLLLCKQKEVEQQTG 884
+ ++ R + LQ + + +L+AT E L +++Q
Sbjct: 2664 TVDELARR-----------EDVRHYLQGRSSIAGLLLKATNEK-----LSVYAALQRQ-- 2705
Query: 885 LSVFLPLVTPDSSALLPSAKADLG---------RIQESSPTKNNIAVSSDHHVISQLQDK 935
L++P ++ +L A+A G R+ + K + HH + +
Sbjct: 2706 ------LLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERA 2759
Query: 936 RLSLSQPILSQQ-NNFKFLQEQLNIQKDSLQ 965
P QQ + F+ +Q+ L +++ ++
Sbjct: 2760 VTGYKDPYTGQQISLFQAMQKGLIVREHGIR 2790
Score = 66.2 bits (160), Expect = 4e-10
Identities = 325/1784 (18%), Positives = 662/1784 (37%), Gaps = 255/1784 (14%)
Query: 50 EDIKQRRNQQFTRLAEELRAEWEESQT----QKIQNLEKLYLASLRSMGEGHRQAKENEP 105
+DI+ + TR LR ++ Q+I +K A + +G+G +
Sbjct: 976 KDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQ-AEVEGLGKGVARLSAEAE 1034
Query: 106 DLDALAQ---RAAERKRKADLRHKEALKVQKNQKEILLKQKTWHIKAR-----KEALLVE 157
+ AL + A + + +L + +V+ L K KT + R +E L
Sbjct: 1035 KVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH 1094
Query: 158 KERSAKITSLPPPPPTLFENIEVKRISAVKTNSSTYHHLHTFVNRETDTKRPDARLAAEE 217
+E+ + ++P P L E + S K + TF D R + R A+E
Sbjct: 1095 EEQLKEAQAVPATLPEL----EATKASLKKLRAQAEAQQPTF-----DALRDELR-GAQE 1144
Query: 218 EAKRLEEL--QKQAAQERM-ERFEKAHVRGFQAMKKIHLAQNQ-EKLMKELKQLQQ---- 269
+RL++ ++ ER ER + R + + + Q + E+L ++L+ ++
Sbjct: 1145 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADP 1204
Query: 270 -----EDLARRRQTVAQMPPQLVELPYKRSEMKEDWQ--RELEFAFEDMYNADRKVKGNL 322
+D RR++ + MP L + R +++++ E+E E + R K
Sbjct: 1205 LGAWLQDARRRQEQIQAMP--LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAK-QY 1261
Query: 323 ILHLEPEPLPTVTNQIQDEELDLSMEQENLGAAEDLPVTEAEICSSETDVPLVMKTQQIP 382
I ++ L VT + Q E + ++ + + + + E + + +Q I
Sbjct: 1262 INAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK 1321
Query: 383 SKVLFKKLLNKIRSQKSLWTIKSMSEDESEMITTVSEIESKAPTVESGTIASKERTLSSG 442
+ L ++ ++ L + +E+ + + +E + E+ A + +
Sbjct: 1322 ---FISETLRRMEEEERL-AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK 1377
Query: 443 ------QEQVVESDTLTIESGPLASEDKPLSCGTNSGKEQEINETLPITTVAQSSVLLHP 496
QE+VV + +++ + E EI A+ S L
Sbjct: 1378 ELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1437
Query: 497 QEA-AARIRMSARQKQIMEIEEQKQKQLELLEQIEQQKLRL--ETDCFRAQLEEEKRKKT 553
+E R+++ A ++Q E + Q E+ E QK + E + R Q+++E ++K
Sbjct: 1438 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR 1497
Query: 554 QPTGVGIAPASCPVISDEDSHRQMIRNYQHQLLQQNRLHRQSVETARKQLLEYQTMLKGR 613
Q A + S + + R Q L L Q+ E R+ L + + R
Sbjct: 1498 Q--------AEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR--LRQAEVERAR 1547
Query: 614 CPSVSAPSLITDSVISVPSWKSERPTAISEHWDQGQRLKLSPNKYQPIQPIQTSKLEQDH 673
V+ + + + S ++ + +E Q +R L+++H
Sbjct: 1548 QVQVALETAQRSAEAELQSKRA----SFAEKTAQLER-----------------SLQEEH 1586
Query: 674 FQVARQNHFPQRQVET-TETLRASDI----LTNQALESQEHLRQFSQTETQQRDYKLVPK 728
VA+ +R+ + E RA + L L++ E LR Q E + L
Sbjct: 1587 VAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQA 1646
Query: 729 DSETLSRALSHDRQLISQDARKISETFGATTFQSLESQQLFSENSENISYHLTEPSSFVP 788
++E ++A + + G Q++ ++L + E L E ++
Sbjct: 1647 EAEKQK-----------EEAEREARRRGKAEEQAVRQRELAEQELEK-QRQLAEGTAQQR 1694
Query: 789 LVPQHSFSSLPVKVESGKIQEPFSAMSKSTVSTSHSIISQMHDRPLLPSENITAQQGNMK 848
L + L + E G+ Q R LL E Q+
Sbjct: 1695 LAAEQELIRLRAETEQGEQQ-----------------------RQLLEEELARLQREAAA 1731
Query: 849 ALQEQLDLQKKVLQATQEAQEQLLLCKQKEVEQQTGLSVFLPLVTPDSSALLPSAKADLG 908
A Q++ +L+ ++ A A+ ++LL + E+++ + S +A+ G
Sbjct: 1732 ATQKRQELEAEL--AKVRAEMEVLLASKARAEEESRST---------SEKSKQRLEAEAG 1780
Query: 909 RIQESSPTKNNIAVSSDHHVISQLQDKRLSLSQPILSQQNNFKFLQEQLNIQKDSLQARR 968
R +E + + ++ + ++L+ + + L E+L ++ + +
Sbjct: 1781 RFRELAEEAARLRALAEE----AKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT 1836
Query: 969 EAQEVLYVHKQSELDR--RVCSEQA--EPSFPFQVAQHTFTSLPSADTKSGKIQEQHSSK 1024
EA E+ K++E +R R+ ++A Q AQH AD + Q + +S
Sbjct: 1837 EA-EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH------KADIEERLAQLRKASD 1889
Query: 1025 SE----KGLV--SCQSDIPISQDGSLSFLQQFLPLHDSLKLLQEQLTKQR----DTLQAR 1074
SE KGLV + + + ++ L+ F L+ +L + R DTL+++
Sbjct: 1890 SELERQKGLVEDTLRQRRQVEEE-ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSK 1948
Query: 1075 HEAQVELLLHRQRDLGDSKSGLVSSSSSPVVVQHSVASQASAKAEPRRIQELYLSEKENV 1134
+A++E RQ + + + VQ S+A++ A + + E K V
Sbjct: 1949 EQAELEAARQRQLAAEEERRRREAEER----VQKSLAAEEEAARQRKAALEEVERLKAKV 2004
Query: 1135 GPSCHLIIPTFQD--KSLSFPQ-------------HSLAQQENLTILQEQSQIQRVILGA 1179
+ L Q+ + L Q H+ A Q+ LQ+ Q ++ +L
Sbjct: 2005 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2064
Query: 1180 KEGTQEFVHTESEL--EKRISSEQTGTSSSLSQVDESERFQECISIKSDSTIPLSHPKIP 1237
G E +E E R+ +E+ S QV+E+ER ++ ++ +
Sbjct: 2065 LRGEAEAARRAAEEAEEARVQAEREAAQSR-RQVEEAERLKQSAEEQAQARAQAQAAAEK 2123
Query: 1238 RCQERLLRVSQHMLPLQDNLEEHQAW-LDTEKEAFHFSQKTQENTSSEQTGSSSFIPQLV 1296
+E ++ Q L + QA + EK Q ++ EQ +L
Sbjct: 2124 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ--------ELT 2175
Query: 1297 QLSFTSLASAESGTILEPLFTESESKIFSSHLQIPQLQDRLLRISQLIQPQQDNLKALQE 1356
L + +L+ +++ + Q Q+++ L + + Q + L L+
Sbjct: 2176 TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV----RVQMEELSKLKA 2231
Query: 1357 QLATQREAIILARQEAREELLLHQSEWEGRISPEQVDTSSLPLVPQHSFASLPLNESERN 1416
++ + A+IL ++ + L ++E +++ E + L + Q + L E +
Sbjct: 2232 RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE---AARLSVAAQEAARLRQLAEEDLA 2288
Query: 1417 QEPCSINSDNIVSSGHSEIPTLPDGLLGLSHLVLPQQDNLIALEEHLHAQTDFLPSIEKT 1476
Q+ L+ +L ++ + L A+ + L +
Sbjct: 2289 QQRA------------------------LAEKMLKEKMQAVQEATRLKAEAELL----QQ 2320
Query: 1477 QKELVLSKPCKFEEKVSSEHFIQSHHGDLQALQQQLDTQKKAIRSIQEVQEELLLQRLSE 1536
QKEL + + +E E Q + Q Q+ L+ +++ + E L L R++E
Sbjct: 2321 QKELAQEQARRLQE--DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL-RVAE 2377
Query: 1537 LEKRVSSEQVCSSSFVSQVPVADSERTQKSFPTKSNDTL--------PSSHREIPRLQDR 1588
+ + + + + F Q + + T+ TL S + RL++
Sbjct: 2378 MSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA 2437
Query: 1589 LLSLSKPILP-QQDNMTAQLDAQREVMYSYEKPQEELSLNKQRKLNKSESAEHTIPSLFL 1647
+ L + QQ+ QL ++ E+ +E +Q L++ +S F+
Sbjct: 2438 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR--ERFI 2495
Query: 1648 PKETEHSFIPLPFAEAKPKSTCELYSSQNEHAAPPSNPVIPGFQD---RLLSFSQSVLTQ 1704
+E AK + E Q + ++ ++ R + V +
Sbjct: 2496 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2555
Query: 1705 QDNLGLQKQLDLQREVLHYSQKAQEKLLVQRQTALQQQIQKHEE 1748
Q+ L +QL+ QR + QE+LL + L++Q+Q EE
Sbjct: 2556 QEEL---QQLEQQR-------RQQEELLAEENQRLREQLQLLEE 2589
Score = 65.5 bits (158), Expect = 7e-10
Identities = 317/1778 (17%), Positives = 637/1778 (35%), Gaps = 269/1778 (15%)
Query: 228 QAAQERMERFEKAHVRGFQAMKKIHLAQNQ----EKLMKELKQLQQEDLARRRQTVAQMP 283
Q AQE + R E H ++H+ + L ++++ ++ LA R +
Sbjct: 849 QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQ 908
Query: 284 PQLV---ELPYKRSEMKEDWQRELEFAFEDMYNADRKVKGNLILHLEPEPLPTVTNQIQD 340
Q + EL Y+ D Q F ED A+R+ G+ H + + L ++ Q+
Sbjct: 909 RQALHSLELHYQA--FLRDSQDAGGFGPEDRLMAEREY-GSCSHHYQ-QLLQSLEQGAQE 964
Query: 341 EELDLSMEQENLGAAEDLPVTEAEICSSETDVPLVMKTQQIPSKVLFKKLLNKIRSQ--- 397
E S Q + +D+ + + E C + T L + + P++ +++ + ++Q
Sbjct: 965 E----SRCQRCISELKDIRL-QLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEV 1019
Query: 398 KSLWTIKSMSEDESEMITTVSEIESKAPTVESG---TIASKERTLSSGQEQVVESDTLTI 454
+ L + E+E + + E APT+ S T+ E+ S + + T+++
Sbjct: 1020 EGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISL 1079
Query: 455 ESGPLASEDKPLSCGTNSGKE-QEINETLPITTVAQSSV--------------------L 493
++ L KE Q + TLP ++S+ L
Sbjct: 1080 VIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDEL 1139
Query: 494 LHPQEAAARIRMSARQKQIMEIEEQKQKQLELLEQIEQQKLRLETDCFRAQLEE------ 547
QE R++ ++ + E+E +++ +LLE+ Q + +TD + +LE+
Sbjct: 1140 RGAQEVGERLQQRHGERDV-EVERWRERVAQLLER--WQAVLAQTDVRQRELEQLGRQLR 1196
Query: 548 EKRKKTQPTGVGIAPA-------SCPVISDEDSHRQMIRNYQHQLLQQNRLHRQSVETAR 600
R+ P G + A ++D + R+ +R Q LL++ H + VE +
Sbjct: 1197 YYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQ-ALLEEIERHGEKVEECQ 1255
Query: 601 KQLLEYQTMLKG---RCPSVSAPSLITDSVISVPSWKSERPTAISEHWD-QGQRLKLSPN 656
+ +Y +K + + A S P +S + I E+ D + +L+
Sbjct: 1256 RFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTL 1315
Query: 657 KYQPIQPI-QTSKLEQDHFQVARQNHFPQRQ--VETTETLRASDILTN-------QALES 706
Q I+ I +T + ++ ++A Q +R+ E L L QA
Sbjct: 1316 TSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAERE 1375
Query: 707 QEHLRQFSQTETQQRDYKLVPKDSETLSRALSHDRQLISQDARKISETFGATTFQSLESQ 766
+ L+Q Q E +R+ V D++ R++ + Q + Q + + A ++ E
Sbjct: 1376 AKELQQRMQEEVVRREEAAV--DAQQQKRSIQEELQQLRQSSEAEIQA-KARQAEAAERS 1432
Query: 767 QLFSENSENISYHLTEPSSFVPLVPQHSFSSLPVKVESGKIQEPFSAMSKSTVSTSHSII 826
+L E + E + + +L + E + Q+ + + +
Sbjct: 1433 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK------RQAQEEAERLR 1486
Query: 827 SQMHDRPLLPSENITAQQGNMKALQEQLDLQKKVLQATQE----AQEQLLLCKQKEVEQQ 882
Q+ D + +KA E +++ LQA +E A+E +Q EVE+
Sbjct: 1487 RQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1546
Query: 883 TGLSVFLPLVTPDSSALLPSAKADLGRIQESSPTKNNIAVSSDHHVISQLQDK------- 935
+ V L + A L S +A + ++ +H ++QL+++
Sbjct: 1547 RQVQVALETAQRSAEAELQSKRASFAE----KTAQLERSLQEEHVAVAQLREEAERRAQQ 1602
Query: 936 --------------------------RLSLSQPILSQQNNFKFLQEQLNIQKDSLQARRE 969
RL L ++QQ + + + ++ +ARR
Sbjct: 1603 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1662
Query: 970 AQEVLYVHKQSELDRRVCSEQ---AEPSFPFQVAQHTFTSLPSADTKSGKIQEQHSSKSE 1026
+ +Q EL + +Q AE + ++A A+T+ G EQ E
Sbjct: 1663 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG---EQQRQLLE 1719
Query: 1027 KGLVSCQSDIPISQDGSLSFLQQFLPLHDSLKLLQEQLTKQRDTLQARHEA---QVELLL 1083
+ L Q + + + + +++L + + ++ E ++E
Sbjct: 1720 EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA 1779
Query: 1084 HRQRDLGDSKSGLVS---------------SSSSPVVVQHSVASQASAKAEPRRIQ---E 1125
R R+L + + L + ++ + +A + +A E R++ E
Sbjct: 1780 GRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE 1839
Query: 1126 LYLSEKENVGPSCHLIIP--TFQDKSLS--FPQHSLAQQENLTILQEQS----------- 1170
+ L EKE + FQ + L QH +E L L++ S
Sbjct: 1840 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV 1899
Query: 1171 --------QIQRVILGAKEGTQEFVHTESELEK---RISSEQTGTSSSLSQVD------- 1212
Q++ IL K ++ ++ELE RI S T S Q +
Sbjct: 1900 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1959
Query: 1213 ------------ESERFQECISIKSDST------------IPLSHPKIPRCQERLLRVSQ 1248
ER Q+ ++ + ++ + + R +ER + S
Sbjct: 1960 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2019
Query: 1249 HMLPLQDNLEEHQAWLDTEKEAFHFSQKTQENTSSEQTGSSSFIPQLVQLSFTSLASAES 1308
L L + + + + AF QK QE + Q S L QL + A+ +
Sbjct: 2020 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV----LDQLRGEAEAARRA 2075
Query: 1309 GTILEPLFTESESKIFSSHLQIPQLQDRLLRISQLIQPQQDNLKALQEQLATQREAIILA 1368
E ++E + S Q+ + + RL + ++ + +A E+L + E
Sbjct: 2076 AEEAEEARVQAEREAAQSRRQVEEAE-RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2134
Query: 1369 RQEAREELLLHQSEWEGRISPEQVDTSSLPLVPQHSFASLPLNESERNQEPCSINSDNIV 1428
R +A + L Q + + FA L + + ++ + +
Sbjct: 2135 RAQAEQAAL------------RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2182
Query: 1429 SSGHS------EIPTLPDGLLGLSHLVLPQQDNLIALEEHLHAQTDFLPSIEKTQKELVL 1482
+ H E+ L + ++ L ++ + + IE + L+L
Sbjct: 2183 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2242
Query: 1483 SKPCKFEEKVSSEHFIQSHHGDLQALQQQLDTQKKAIRSIQEVQEELLLQRLSELEKRVS 1542
+K +++ F+Q + ++ ++A R QE L++L+E + ++
Sbjct: 2243 ------RDKDNTQRFLQ------EEAEKMKQVAEEAARLSVAAQEAARLRQLAEED--LA 2288
Query: 1543 SEQVCSSSFVSQVPVADSERTQKSFPTKSNDTLPSSHREIPRLQDRLLSLSKPILPQQ-- 1600
++ + + + A E T+ K+ L +E+ + Q R L K + QQ
Sbjct: 2289 QQRALAEKMLKEKMQAVQEATR----LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2344
Query: 1601 ---DNMTAQLDAQREVMYSYEKPQEELSLNKQRKLNKSESAEHTIPSLFLPKETEHSFIP 1657
L+A+R+ E L L AE K+ E
Sbjct: 2345 EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF--RKQAEEIGEK 2402
Query: 1658 LPFAEAKPKS------TCELYSSQNEHAAPPSNPVIPGFQDRLLSFSQS-----VLTQQD 1706
L E + T E+ Q++H A I + Q + +++
Sbjct: 2403 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2462
Query: 1707 NLGLQKQLDLQREVLHYSQKAQEKLLVQRQTALQQQIQKHEETLKDFFKDSQISKPTVEN 1766
Q+QL + + L S +++ L+QR+ ++Q+ K E+ +D +Q + E
Sbjct: 2463 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE--EQ 2520
Query: 1767 DLKTQKMGQLRDWFPNTQDLAGNDQENIRHADRNNSDD 1804
+ Q+M Q R + + A Q R ++
Sbjct: 2521 QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE 2558
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 73.9 bits (180), Expect = 2e-12
Identities = 305/1563 (19%), Positives = 588/1563 (37%), Gaps = 252/1563 (16%)
Query: 35 LQVREQERDIALQIREDIKQRRNQQFTRLAEELRAEWEESQTQKIQNLEKLYLASLRSMG 94
LQ R ERD+ ++ R ++ +L E +A ++ ++ + L +G
Sbjct: 1190 LQQRHGERDVEVE-------RWRERVAQLLERWQAVLAQTDVRQRE---------LEQLG 1233
Query: 95 EGHRQAKENEPDLDALAQRAAERKRKAD---LRHKEALKVQKNQKEILLKQKTWHIKARK 151
R +E+ L A Q A R+ + L +A++ Q Q++ LL++ H + +
Sbjct: 1234 RQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVE 1293
Query: 152 EALLVEKERSAKITSLPPPPPTLFENIEVKRISAVKTNSST--------YHHLHTFVNRE 203
E K+ I T +E A K + Y L T +
Sbjct: 1294 ECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSEL 1353
Query: 204 TDTKRPDARLAAE-----EEAKRLEELQKQAAQERMERFEKAHVRGFQAMKKIHLAQNQ- 257
T + +E EE +RL E Q+ +ER+ E A + Q + A+ Q
Sbjct: 1354 TTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQA 1413
Query: 258 EKLMKELKQLQQEDLARRRQTVAQMPPQLVELPYKRSEMKEDWQRELEFAFEDMYNADR- 316
E+ KEL+Q QE++ RR + Q + + ++++ + E++ A+R
Sbjct: 1414 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS 1473
Query: 317 --KVKGNL-ILHLEPEPLPTVTNQIQDEELDLSMEQENLGAAEDLPVTEAEICSSETDVP 373
+++ + ++ L+ E + E L E A + EAE +
Sbjct: 1474 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1533
Query: 374 LVMKTQ---QIPSKVL--FKKLLNKIRSQKSLWTIKSMSED------------------- 409
K Q ++ S+V + K R+ ++L ++ +E+
Sbjct: 1534 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1593
Query: 410 -ESEMITTVSEIESKAPTVESGTIASKERTLSSGQEQVVESDTLTIESGPLASEDKPLSC 468
E+ + +E++SK + T A ER+L QE+ V L E+ A +
Sbjct: 1594 LETAQRSAEAELQSKRASFAEKT-AQLERSL---QEEHVAVAQLREEAERRAQQQAEAER 1649
Query: 469 GTNSGKEQ------EINETLPI----------TTVAQSSVLLHPQEAAARIR-------M 505
+ + + NE L + ++AQ+ +EA R
Sbjct: 1650 AREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQ 1709
Query: 506 SARQKQIMEIEEQKQKQL-------------ELL------EQIEQQKLRLETDCFRAQLE 546
+ RQ+++ E E +KQ+QL EL+ EQ EQQ+ LE + R Q E
Sbjct: 1710 AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1769
Query: 547 ----EEKRKKTQPTGVGIAPASCPVI------SDEDSHRQMIRNYQHQLLQQNRLHRQSV 596
+KR++ + + A V+ ++E+S ++ Q + R +
Sbjct: 1770 AAAATQKRQELE-AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1828
Query: 597 ETARKQLLEYQTMLKGRCPS-------VSAPSLITDSVISV---PSWKSERPTAISEHWD 646
E AR + L + + + A ++ + + ++ K+E A+ E
Sbjct: 1829 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1888
Query: 647 QGQRLKLSPNKYQPIQPIQTSKLEQDHFQVARQNHFPQRQVETTETLRASDI-LTNQALE 705
+ +RL+ + + Q +LE+ Q H + + +ASD L Q
Sbjct: 1889 ENERLR----RLAEDEAFQRRRLEEQAAQ-----HKADIEERLAQLRKASDSELERQKGL 1939
Query: 706 SQEHLRQFSQTETQQRDYKLVPKDSETLSRALSHDRQLISQDARKISETFGATTFQSLES 765
++ LRQ Q E + K + + L + I +A + ++
Sbjct: 1940 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1999
Query: 766 QQLFSENSENISYHLTEPSSFVPLVPQHSFSSLPVKVESGKIQEPFSAMSKSTVSTSHSI 825
+QL +E E V Q S ++ +E + K+ + +
Sbjct: 2000 RQLAAEEER----RRREAEERV----QKSLAA----------EEEAARQRKAALEEVERL 2041
Query: 826 ISQMHDRPLLPSENITAQQGNMKALQEQLDLQKKVLQATQEAQEQLLLCKQKEVEQ--QT 883
+++ + L A+Q + + LQ + +K LQA ++A + K++E++Q Q
Sbjct: 2042 KAKVEEARRLRER---AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2098
Query: 884 GLSVFLPLVTPDSSALLPSAKADLGRIQ-ESSPTKNNIAVSSDHHVISQLQDKRLSLSQP 942
SV L +A + +A+ R+Q E ++ V + +++ + +Q
Sbjct: 2099 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQA 2158
Query: 943 ILSQQNNFKFLQEQLNIQKDSLQARR-EAQEVLYVHKQ---SELDRRVCSEQAEPSFPFQ 998
+ E+L + + ARR +A++ KQ +E+++ + Q
Sbjct: 2159 --------QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQ 2210
Query: 999 VAQHTFT---SLPSADTKSGKIQEQHSSKSEKGLVSCQSDIPISQDGSLSFLQQFLPLHD 1055
V Q T L D + + E+ + + + + ++
Sbjct: 2211 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE------------LF 2258
Query: 1056 SLKLLQEQLTKQRDTLQARHEAQVELLLHRQRDLGD---SKSGLVSSSSSPVVVQHSVAS 1112
S+++ E+L+K L+AR EA+ L+ R +D + + + SVA+
Sbjct: 2259 SVRVQMEELSK----LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2314
Query: 1113 QASAK---------AEPRRIQELYLSEK-ENVGPSCHLIIPTFQDKSLSFPQHSLAQQEN 1162
Q +A+ A+ R + E L EK + V + L + L Q LAQ++
Sbjct: 2315 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL----KAEAELLQQQKELAQEQA 2370
Query: 1163 LTILQEQSQIQRVILGAKEGTQEFVHTESELEKRISSEQTGTSSSLSQV--------DES 1214
+ +++ Q+ + + +G Q + E + + +S+E ++++ +++
Sbjct: 2371 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2430
Query: 1215 ERFQ---ECISIKSDSTIPLSHPKIPRCQ--ERLLRVSQHMLPLQDNLEEHQAWLDTEKE 1269
+RF+ E I K T + K+ Q E + S H + L E A L+ EKE
Sbjct: 2431 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD---AERLREAIAELEREKE 2487
Query: 1270 AFHFSQKTQENTSSE-QTGSSSFIPQLVQLSFTSLASAESGTILEPLFTESESKIFSSHL 1328
K + S E QT + Q Q S S + + F E E
Sbjct: 2488 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK------A 2541
Query: 1329 QIPQL-QDRLLRISQLIQPQQDNLKALQEQLATQREAIILARQEAREELLLHQSEWEGRI 1387
++ QL QD + + QL + QQ Q+Q+ +R+ ++ + +EAR Q E E +
Sbjct: 2542 KLEQLFQDEVAKAQQLREEQQRQ----QQQMEQERQRLVASMEEARR----RQHEAEEGV 2593
Query: 1388 SPEQVDTSSLP---------LVPQHSFASLPLNESERNQEPCSINSDNIVSSGHSEIPTL 1438
+Q + L L ++ L E +S+ + +S + TL
Sbjct: 2594 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTL 2653
Query: 1439 PDG 1441
P+G
Sbjct: 2654 PNG 2656
Score = 73.6 bits (179), Expect = 2e-12
Identities = 238/1240 (19%), Positives = 472/1240 (38%), Gaps = 148/1240 (11%)
Query: 10 KLRLSPNEEAFILKEDYERRRKLRLLQVREQERDIALQIREDIKQRRNQQFTRLAEELRA 69
+LR S E E + RL ++ E+ R + LQ+ +QR + A RA
Sbjct: 1451 QLRQSSEAEIQAKARQAEAAERSRL-RIEEEIRVVRLQLEATERQRGGAEGELQALRARA 1509
Query: 70 EWEESQTQKIQNLEKLYLASLRSMGEGHRQAKENEPDLDALAQRAAERKRKADLRHKEAL 129
E E+Q ++ Q + ++ + RQA E E A+ A R+++ L+ E L
Sbjct: 1510 EEAEAQKRQAQEEAERLRRQVQDESQRKRQA-EVELASRVKAEAEAAREKQRALQALEEL 1568
Query: 130 KVQKNQKEILLKQKTWHIKARKEALLVEKERSAKITSLPPPPPTLFENIEVKRISAVKTN 189
++Q + E L+Q + + L +RSA+ ++ KR S +
Sbjct: 1569 RLQAEEAERRLRQAEVERARQVQVALETAQRSAE------------AELQSKRASFAEKT 1616
Query: 190 SSTYHHLHTFVNRETDTKRPDARLAAEEEAKRLEELQKQAAQERMER-FEKAHVRGFQAM 248
+ L + A+L E E + ++ + + A+E ER E+ ++ +A+
Sbjct: 1617 AQLERSLQ-------EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1669
Query: 249 KKIHLAQNQEKLMKELKQLQQEDLARRRQTVAQMPPQLVELPYKRSEMKE---DWQREL- 304
++ L + K L Q + E + A+ + E ++ E+ E + QR+L
Sbjct: 1670 -RLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLA 1728
Query: 305 EFAFEDMYNADRKVKGNLILHLEPEPLPTVTNQIQDEELDLSMEQENLGAAEDLPVTEAE 364
E + A++++ + L E E Q+ +EEL +++E A + EAE
Sbjct: 1729 EGTAQQRLAAEQEL---IRLRAETEQ-GEQQRQLLEEEL-ARLQREAAAATQKRQELEAE 1783
Query: 365 ICS--SETDVPLVMKTQ-QIPSKVLFKKLLNKIRSQKSLWTIKSMSEDESEMITTVSEIE 421
+ +E +V L K + + S+ +K +K R + + ++E+ + + E +
Sbjct: 1784 LAKVRAEMEVLLASKARAEEESRSTSEK--SKQRLEAEAGRFRELAEEAARLRALAEEAK 1841
Query: 422 SKAPTVESGTI---ASKERTLSSGQEQVVESDTLTIESGPLASEDKPLSCGTNSGKEQEI 478
+ E A ER L+ + E+ L E+ E + + E E
Sbjct: 1842 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1901
Query: 479 NETLPITTVAQSSVLLHPQEAAARIRMSA-----RQKQIME--IEEQKQKQLELL----- 526
+ + A + +E A++R ++ RQK ++E + +++Q + E+L
Sbjct: 1902 FQRRRLEEQA-AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKAS 1960
Query: 527 ---EQIEQQKLRLETDCFRAQLEEEKRKKTQPTGVGIAPASCPVISDEDSHRQMIRNYQH 583
+ +L LE R+ E+ R K Q + A +E R+ Q
Sbjct: 1961 FEKAAAGKAELELELGRIRSNAEDTLRSKEQ-AELEAARQRQLAAEEERRRREAEERVQK 2019
Query: 584 QLLQQNRLHRQSVETAR-----KQLLEYQTMLKGRCPSVSAPSLITDSVISVPSWKSERP 638
L + RQ K +E L+ R SA L + ++E
Sbjct: 2020 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK 2079
Query: 639 TAISEHWDQGQRLKLSPNKYQPI----------QPIQTSKLEQDHFQVARQNHFPQRQVE 688
+ Q L+ + + Q + + E+ Q R+ +RQVE
Sbjct: 2080 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2139
Query: 689 TTETLRASDILTNQALESQEHLRQFSQTETQQRDYKLVPKDSETLSRALSHDRQLISQDA 748
E L+ S QA + + + E +Q + + L + + D ++ +
Sbjct: 2140 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM--EKH 2197
Query: 749 RKISETFGATTFQSLESQQLFSENSENISYHLTEPSSFVPLVPQHSFSSLPVKVESGKIQ 808
+K +E Q+L + + + L E H + L +++ K +
Sbjct: 2198 KKFAE-------QTLRQKAQVEQELTTLRLQLEE--------TDHQKNLLDEELQRLKAE 2242
Query: 809 EPFSAMSKSTVSTS-HSIISQMHD----RPLLPSEN----ITAQQGNMKALQEQLDLQKK 859
+A +S V S+ QM + + + +EN + + + LQE+ + K+
Sbjct: 2243 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2302
Query: 860 VLQ-------ATQEAQEQLLLCKQKEVEQQTGLSVFLPLVTPDSSALLPSAKADLGRIQE 912
V + A QEA +L ++++ QQ L+ + K + +QE
Sbjct: 2303 VAEEAARLSVAAQEA-ARLRQLAEEDLAQQRALAEKM-------------LKEKMQAVQE 2348
Query: 913 SSPTKNNIAVSSDHHVISQLQDKRL-----SLSQPILSQQNNFKFL-----QEQLNIQKD 962
++ K + ++Q Q +RL ++Q + + F+ Q QL + +
Sbjct: 2349 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE 2408
Query: 963 SLQARREAQEVLYVHKQSELDRRVCSEQAEPSFPFQVAQHTFTSLPSADTKSGKIQEQHS 1022
+ + + E+ ++E D + +QAE T ++ +IQ Q S
Sbjct: 2409 AERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2468
Query: 1023 SKSEKGLVSCQSDI-----PISQDGSLSFLQQFLPLHDSLKLLQEQLTKQRDTLQARHEA 1077
+ L +++ + Q+ L L+ + + QEQL ++ LQ +
Sbjct: 2469 DHDAERLREAIAELEREKEKLQQEAKLLQLKS----EEMQTVQQEQLLQETQALQQSFLS 2524
Query: 1078 QVELLLHRQRDLGDSKSGLVSSSSSPVVVQHSVASQASAKAEPRRIQELYLSEKENVGPS 1137
+ + LL R+R + K+ L + Q VA + E +R Q+ E++ + S
Sbjct: 2525 EKDSLLQRERFIEQEKAKLEQ------LFQDEVAKAQQLREEQQRQQQQMEQERQRLVAS 2578
Query: 1138 CHLIIPTFQDKSLSFPQHSLAQQENLTILQEQSQIQRVIL 1177
+ + + + +QE L L++Q + Q +L
Sbjct: 2579 ----MEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2614
Score = 69.7 bits (169), Expect = 4e-11
Identities = 209/1051 (19%), Positives = 404/1051 (38%), Gaps = 170/1051 (16%)
Query: 17 EEAFILKEDYERRRKLRLLQVREQER---DIALQIREDIKQRRNQQFTRLAEE---LRAE 70
E+A + + ER +L + E R + + ++E K+ N++ RLAE+ R
Sbjct: 1849 EDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE--KEAENERLRRLAEDEAFQRRR 1906
Query: 71 WEESQTQKIQNLEKLYLASLRSMGEGH---------------RQAKENEPDLDALAQRAA 115
EE Q ++E+ LA LR + RQ +E L A ++AA
Sbjct: 1907 LEEQAAQHKADIEER-LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA 1965
Query: 116 ERKRKADLRHKEALKVQKNQKEILLKQKTWHIKA-RKEALLVEKERSAKITSLPPPPPTL 174
K + +L E +++ N ++ L ++ ++A R+ L E+ER
Sbjct: 1966 AGKAELEL---ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR------------- 2009
Query: 175 FENIEVKRISAVKTNSSTYHHLHTFVNRETDTKRPDARLAAEEEAKRLEE---------- 224
+R + + S R+ + + A EEA+RL E
Sbjct: 2010 ------RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2063
Query: 225 -LQKQAAQERMERFEKAHVRGFQAMKKIHLAQNQEKLMKELKQLQQE-DLARRRQTVAQM 282
L ++AAQ+R++ EKAH Q K+ L Q ++ L QL+ E + ARR A+
Sbjct: 2064 QLAQEAAQKRLQAEEKAHAFAVQ-QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2122
Query: 283 PPQLVELPYKRSEMKEDWQRELEFAFEDMYNADRKVKGNLILHLEPEPLPTVTNQIQDEE 342
E +S + + L+ + E+ A + + L E + Q E+
Sbjct: 2123 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA-AAEKLRKEAEQEAARRAQAEQ 2181
Query: 343 LDLSMEQ-------ENLGAAEDLPVTEAEICSSETDVPLVMKTQQIPSKVLFKKLLN--- 392
L +Q ++ AE +A++ T + L ++ +L ++L
Sbjct: 2182 AALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKA 2241
Query: 393 ------KIRSQ--KSLWTIKSMSEDESEMITTVSEIESKAPTVESGTIASKERTLSSGQE 444
+ RSQ + L++++ E+ S++ + E E++A + K+ T QE
Sbjct: 2242 EATEAARQRSQVEEELFSVRVQMEELSKLKARI-EAENRAL-----ILRDKDNTQRFLQE 2295
Query: 445 QVVESDTLTIESGPLASEDKPLSCGTNSGKEQEINETLPITTVAQSSVLLHPQEA---AA 501
+ + + E+ L+ ++ + Q E L +L +A A
Sbjct: 2296 EAEKMKQVAEEAARLS-----VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT 2350
Query: 502 RIRMSAR--QKQIMEIEEQKQKQLELLEQIEQQKLRLETDCFRAQLEEEKRKKTQPTG-- 557
R++ A Q+Q +EQ ++ E EQ+ QQ L ET F+ LE E++++ + +
Sbjct: 2351 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ-LAEETQGFQRTLEAERQRQLEMSAEA 2409
Query: 558 ----VGIAPAS-CPVISDEDSHRQMIRNYQHQLLQQNRLHRQSVETARKQLLEYQTMLKG 612
+ +A S ++ED+ R R ++ +LHR + T K L QT+
Sbjct: 2410 ERLKLRVAEMSRAQARAEEDAQR--FRKQAEEI--GEKLHRTELATQEKVTL-VQTLEIQ 2464
Query: 613 RCPSVSAPSLITDSVISVPSWKS--ERPTAISEHWDQGQRLKLSPNKYQPIQPIQTSKLE 670
R S + +++ + K ++ + + + + Q Q +Q S L
Sbjct: 2465 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2524
Query: 671 QDHFQVARQNHFPQRQVETTETLRASDILTNQALESQEHLRQFSQTETQQ-----RDYKL 725
+ + R+ Q + + + + Q E Q+ +Q + E Q+ + +
Sbjct: 2525 EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2584
Query: 726 VPKDSETLSRALSHDRQLISQDARKISETFGATTFQSLESQQLFSE-------NSENISY 778
++E R + Q + Q R+ E + E QL E +SE ++
Sbjct: 2585 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2644
Query: 779 HLTEPSSFVP------------LVPQHSFSSLPVKVESGKIQEP--FSAMSKSTVSTSHS 824
+ +P P+HSF L KV + ++QE SA ++ H+
Sbjct: 2645 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2704
Query: 825 IISQMHDRPLLPSENITAQQGNMKALQEQLDLQKKVLQATQEAQEQLLLCKQKEVEQQTG 884
+ ++ R + LQ + + +L+AT E L +++Q
Sbjct: 2705 TVDELARR-----------EDVRHYLQGRSSIAGLLLKATNEK-----LSVYAALQRQ-- 2746
Query: 885 LSVFLPLVTPDSSALLPSAKADLG---------RIQESSPTKNNIAVSSDHHVISQLQDK 935
L++P ++ +L A+A G R+ + K + HH + +
Sbjct: 2747 ------LLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERA 2800
Query: 936 RLSLSQPILSQQ-NNFKFLQEQLNIQKDSLQ 965
P QQ + F+ +Q+ L +++ ++
Sbjct: 2801 VTGYKDPYTGQQISLFQAMQKGLIVREHGIR 2831
Score = 66.2 bits (160), Expect = 4e-10
Identities = 325/1784 (18%), Positives = 662/1784 (37%), Gaps = 255/1784 (14%)
Query: 50 EDIKQRRNQQFTRLAEELRAEWEESQT----QKIQNLEKLYLASLRSMGEGHRQAKENEP 105
+DI+ + TR LR ++ Q+I +K A + +G+G +
Sbjct: 1017 KDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQ-AEVEGLGKGVARLSAEAE 1075
Query: 106 DLDALAQ---RAAERKRKADLRHKEALKVQKNQKEILLKQKTWHIKAR-----KEALLVE 157
+ AL + A + + +L + +V+ L K KT + R +E L
Sbjct: 1076 KVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH 1135
Query: 158 KERSAKITSLPPPPPTLFENIEVKRISAVKTNSSTYHHLHTFVNRETDTKRPDARLAAEE 217
+E+ + ++P P L E + S K + TF D R + R A+E
Sbjct: 1136 EEQLKEAQAVPATLPEL----EATKASLKKLRAQAEAQQPTF-----DALRDELR-GAQE 1185
Query: 218 EAKRLEEL--QKQAAQERM-ERFEKAHVRGFQAMKKIHLAQNQ-EKLMKELKQLQQ---- 269
+RL++ ++ ER ER + R + + + Q + E+L ++L+ ++
Sbjct: 1186 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADP 1245
Query: 270 -----EDLARRRQTVAQMPPQLVELPYKRSEMKEDWQ--RELEFAFEDMYNADRKVKGNL 322
+D RR++ + MP L + R +++++ E+E E + R K
Sbjct: 1246 LGAWLQDARRRQEQIQAMP--LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAK-QY 1302
Query: 323 ILHLEPEPLPTVTNQIQDEELDLSMEQENLGAAEDLPVTEAEICSSETDVPLVMKTQQIP 382
I ++ L VT + Q E + ++ + + + + E + + +Q I
Sbjct: 1303 INAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK 1362
Query: 383 SKVLFKKLLNKIRSQKSLWTIKSMSEDESEMITTVSEIESKAPTVESGTIASKERTLSSG 442
+ L ++ ++ L + +E+ + + +E + E+ A + +
Sbjct: 1363 ---FISETLRRMEEEERL-AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK 1418
Query: 443 ------QEQVVESDTLTIESGPLASEDKPLSCGTNSGKEQEINETLPITTVAQSSVLLHP 496
QE+VV + +++ + E EI A+ S L
Sbjct: 1419 ELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1478
Query: 497 QEA-AARIRMSARQKQIMEIEEQKQKQLELLEQIEQQKLRL--ETDCFRAQLEEEKRKKT 553
+E R+++ A ++Q E + Q E+ E QK + E + R Q+++E ++K
Sbjct: 1479 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR 1538
Query: 554 QPTGVGIAPASCPVISDEDSHRQMIRNYQHQLLQQNRLHRQSVETARKQLLEYQTMLKGR 613
Q A + S + + R Q L L Q+ E R+ L + + R
Sbjct: 1539 Q--------AEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR--LRQAEVERAR 1588
Query: 614 CPSVSAPSLITDSVISVPSWKSERPTAISEHWDQGQRLKLSPNKYQPIQPIQTSKLEQDH 673
V+ + + + S ++ + +E Q +R L+++H
Sbjct: 1589 QVQVALETAQRSAEAELQSKRA----SFAEKTAQLER-----------------SLQEEH 1627
Query: 674 FQVARQNHFPQRQVET-TETLRASDI----LTNQALESQEHLRQFSQTETQQRDYKLVPK 728
VA+ +R+ + E RA + L L++ E LR Q E + L
Sbjct: 1628 VAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQA 1687
Query: 729 DSETLSRALSHDRQLISQDARKISETFGATTFQSLESQQLFSENSENISYHLTEPSSFVP 788
++E ++A + + G Q++ ++L + E L E ++
Sbjct: 1688 EAEKQK-----------EEAEREARRRGKAEEQAVRQRELAEQELEK-QRQLAEGTAQQR 1735
Query: 789 LVPQHSFSSLPVKVESGKIQEPFSAMSKSTVSTSHSIISQMHDRPLLPSENITAQQGNMK 848
L + L + E G+ Q R LL E Q+
Sbjct: 1736 LAAEQELIRLRAETEQGEQQ-----------------------RQLLEEELARLQREAAA 1772
Query: 849 ALQEQLDLQKKVLQATQEAQEQLLLCKQKEVEQQTGLSVFLPLVTPDSSALLPSAKADLG 908
A Q++ +L+ ++ A A+ ++LL + E+++ + S +A+ G
Sbjct: 1773 ATQKRQELEAEL--AKVRAEMEVLLASKARAEEESRST---------SEKSKQRLEAEAG 1821
Query: 909 RIQESSPTKNNIAVSSDHHVISQLQDKRLSLSQPILSQQNNFKFLQEQLNIQKDSLQARR 968
R +E + + ++ + ++L+ + + L E+L ++ + +
Sbjct: 1822 RFRELAEEAARLRALAEE----AKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT 1877
Query: 969 EAQEVLYVHKQSELDR--RVCSEQA--EPSFPFQVAQHTFTSLPSADTKSGKIQEQHSSK 1024
EA E+ K++E +R R+ ++A Q AQH AD + Q + +S
Sbjct: 1878 EA-EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH------KADIEERLAQLRKASD 1930
Query: 1025 SE----KGLV--SCQSDIPISQDGSLSFLQQFLPLHDSLKLLQEQLTKQR----DTLQAR 1074
SE KGLV + + + ++ L+ F L+ +L + R DTL+++
Sbjct: 1931 SELERQKGLVEDTLRQRRQVEEE-ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSK 1989
Query: 1075 HEAQVELLLHRQRDLGDSKSGLVSSSSSPVVVQHSVASQASAKAEPRRIQELYLSEKENV 1134
+A++E RQ + + + VQ S+A++ A + + E K V
Sbjct: 1990 EQAELEAARQRQLAAEEERRRREAEER----VQKSLAAEEEAARQRKAALEEVERLKAKV 2045
Query: 1135 GPSCHLIIPTFQD--KSLSFPQ-------------HSLAQQENLTILQEQSQIQRVILGA 1179
+ L Q+ + L Q H+ A Q+ LQ+ Q ++ +L
Sbjct: 2046 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2105
Query: 1180 KEGTQEFVHTESEL--EKRISSEQTGTSSSLSQVDESERFQECISIKSDSTIPLSHPKIP 1237
G E +E E R+ +E+ S QV+E+ER ++ ++ +
Sbjct: 2106 LRGEAEAARRAAEEAEEARVQAEREAAQSR-RQVEEAERLKQSAEEQAQARAQAQAAAEK 2164
Query: 1238 RCQERLLRVSQHMLPLQDNLEEHQAW-LDTEKEAFHFSQKTQENTSSEQTGSSSFIPQLV 1296
+E ++ Q L + QA + EK Q ++ EQ +L
Sbjct: 2165 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ--------ELT 2216
Query: 1297 QLSFTSLASAESGTILEPLFTESESKIFSSHLQIPQLQDRLLRISQLIQPQQDNLKALQE 1356
L + +L+ +++ + Q Q+++ L + + Q + L L+
Sbjct: 2217 TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV----RVQMEELSKLKA 2272
Query: 1357 QLATQREAIILARQEAREELLLHQSEWEGRISPEQVDTSSLPLVPQHSFASLPLNESERN 1416
++ + A+IL ++ + L ++E +++ E + L + Q + L E +
Sbjct: 2273 RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE---AARLSVAAQEAARLRQLAEEDLA 2329
Query: 1417 QEPCSINSDNIVSSGHSEIPTLPDGLLGLSHLVLPQQDNLIALEEHLHAQTDFLPSIEKT 1476
Q+ L+ +L ++ + L A+ + L +
Sbjct: 2330 QQRA------------------------LAEKMLKEKMQAVQEATRLKAEAELL----QQ 2361
Query: 1477 QKELVLSKPCKFEEKVSSEHFIQSHHGDLQALQQQLDTQKKAIRSIQEVQEELLLQRLSE 1536
QKEL + + +E E Q + Q Q+ L+ +++ + E L L R++E
Sbjct: 2362 QKELAQEQARRLQE--DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL-RVAE 2418
Query: 1537 LEKRVSSEQVCSSSFVSQVPVADSERTQKSFPTKSNDTL--------PSSHREIPRLQDR 1588
+ + + + + F Q + + T+ TL S + RL++
Sbjct: 2419 MSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA 2478
Query: 1589 LLSLSKPILP-QQDNMTAQLDAQREVMYSYEKPQEELSLNKQRKLNKSESAEHTIPSLFL 1647
+ L + QQ+ QL ++ E+ +E +Q L++ +S F+
Sbjct: 2479 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR--ERFI 2536
Query: 1648 PKETEHSFIPLPFAEAKPKSTCELYSSQNEHAAPPSNPVIPGFQD---RLLSFSQSVLTQ 1704
+E AK + E Q + ++ ++ R + V +
Sbjct: 2537 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2596
Query: 1705 QDNLGLQKQLDLQREVLHYSQKAQEKLLVQRQTALQQQIQKHEE 1748
Q+ L +QL+ QR + QE+LL + L++Q+Q EE
Sbjct: 2597 QEEL---QQLEQQR-------RQQEELLAEENQRLREQLQLLEE 2630
Score = 65.5 bits (158), Expect = 7e-10
Identities = 317/1778 (17%), Positives = 637/1778 (35%), Gaps = 269/1778 (15%)
Query: 228 QAAQERMERFEKAHVRGFQAMKKIHLAQNQ----EKLMKELKQLQQEDLARRRQTVAQMP 283
Q AQE + R E H ++H+ + L ++++ ++ LA R +
Sbjct: 890 QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQ 949
Query: 284 PQLV---ELPYKRSEMKEDWQRELEFAFEDMYNADRKVKGNLILHLEPEPLPTVTNQIQD 340
Q + EL Y+ D Q F ED A+R+ G+ H + + L ++ Q+
Sbjct: 950 RQALHSLELHYQA--FLRDSQDAGGFGPEDRLMAEREY-GSCSHHYQ-QLLQSLEQGAQE 1005
Query: 341 EELDLSMEQENLGAAEDLPVTEAEICSSETDVPLVMKTQQIPSKVLFKKLLNKIRSQ--- 397
E S Q + +D+ + + E C + T L + + P++ +++ + ++Q
Sbjct: 1006 E----SRCQRCISELKDIRL-QLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEV 1060
Query: 398 KSLWTIKSMSEDESEMITTVSEIESKAPTVESG---TIASKERTLSSGQEQVVESDTLTI 454
+ L + E+E + + E APT+ S T+ E+ S + + T+++
Sbjct: 1061 EGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISL 1120
Query: 455 ESGPLASEDKPLSCGTNSGKE-QEINETLPITTVAQSSV--------------------L 493
++ L KE Q + TLP ++S+ L
Sbjct: 1121 VIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDEL 1180
Query: 494 LHPQEAAARIRMSARQKQIMEIEEQKQKQLELLEQIEQQKLRLETDCFRAQLEE------ 547
QE R++ ++ + E+E +++ +LLE+ Q + +TD + +LE+
Sbjct: 1181 RGAQEVGERLQQRHGERDV-EVERWRERVAQLLER--WQAVLAQTDVRQRELEQLGRQLR 1237
Query: 548 EKRKKTQPTGVGIAPA-------SCPVISDEDSHRQMIRNYQHQLLQQNRLHRQSVETAR 600
R+ P G + A ++D + R+ +R Q LL++ H + VE +
Sbjct: 1238 YYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQ-ALLEEIERHGEKVEECQ 1296
Query: 601 KQLLEYQTMLKG---RCPSVSAPSLITDSVISVPSWKSERPTAISEHWD-QGQRLKLSPN 656
+ +Y +K + + A S P +S + I E+ D + +L+
Sbjct: 1297 RFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTL 1356
Query: 657 KYQPIQPI-QTSKLEQDHFQVARQNHFPQRQ--VETTETLRASDILTN-------QALES 706
Q I+ I +T + ++ ++A Q +R+ E L L QA
Sbjct: 1357 TSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAERE 1416
Query: 707 QEHLRQFSQTETQQRDYKLVPKDSETLSRALSHDRQLISQDARKISETFGATTFQSLESQ 766
+ L+Q Q E +R+ V D++ R++ + Q + Q + + A ++ E
Sbjct: 1417 AKELQQRMQEEVVRREEAAV--DAQQQKRSIQEELQQLRQSSEAEIQA-KARQAEAAERS 1473
Query: 767 QLFSENSENISYHLTEPSSFVPLVPQHSFSSLPVKVESGKIQEPFSAMSKSTVSTSHSII 826
+L E + E + + +L + E + Q+ + + +
Sbjct: 1474 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK------RQAQEEAERLR 1527
Query: 827 SQMHDRPLLPSENITAQQGNMKALQEQLDLQKKVLQATQE----AQEQLLLCKQKEVEQQ 882
Q+ D + +KA E +++ LQA +E A+E +Q EVE+
Sbjct: 1528 RQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1587
Query: 883 TGLSVFLPLVTPDSSALLPSAKADLGRIQESSPTKNNIAVSSDHHVISQLQDK------- 935
+ V L + A L S +A + ++ +H ++QL+++
Sbjct: 1588 RQVQVALETAQRSAEAELQSKRASFAE----KTAQLERSLQEEHVAVAQLREEAERRAQQ 1643
Query: 936 --------------------------RLSLSQPILSQQNNFKFLQEQLNIQKDSLQARRE 969
RL L ++QQ + + + ++ +ARR
Sbjct: 1644 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1703
Query: 970 AQEVLYVHKQSELDRRVCSEQ---AEPSFPFQVAQHTFTSLPSADTKSGKIQEQHSSKSE 1026
+ +Q EL + +Q AE + ++A A+T+ G EQ E
Sbjct: 1704 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG---EQQRQLLE 1760
Query: 1027 KGLVSCQSDIPISQDGSLSFLQQFLPLHDSLKLLQEQLTKQRDTLQARHEA---QVELLL 1083
+ L Q + + + + +++L + + ++ E ++E
Sbjct: 1761 EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA 1820
Query: 1084 HRQRDLGDSKSGLVS---------------SSSSPVVVQHSVASQASAKAEPRRIQ---E 1125
R R+L + + L + ++ + +A + +A E R++ E
Sbjct: 1821 GRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE 1880
Query: 1126 LYLSEKENVGPSCHLIIP--TFQDKSLS--FPQHSLAQQENLTILQEQS----------- 1170
+ L EKE + FQ + L QH +E L L++ S
Sbjct: 1881 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV 1940
Query: 1171 --------QIQRVILGAKEGTQEFVHTESELEK---RISSEQTGTSSSLSQVD------- 1212
Q++ IL K ++ ++ELE RI S T S Q +
Sbjct: 1941 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 2000
Query: 1213 ------------ESERFQECISIKSDST------------IPLSHPKIPRCQERLLRVSQ 1248
ER Q+ ++ + ++ + + R +ER + S
Sbjct: 2001 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2060
Query: 1249 HMLPLQDNLEEHQAWLDTEKEAFHFSQKTQENTSSEQTGSSSFIPQLVQLSFTSLASAES 1308
L L + + + + AF QK QE + Q S L QL + A+ +
Sbjct: 2061 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV----LDQLRGEAEAARRA 2116
Query: 1309 GTILEPLFTESESKIFSSHLQIPQLQDRLLRISQLIQPQQDNLKALQEQLATQREAIILA 1368
E ++E + S Q+ + + RL + ++ + +A E+L + E
Sbjct: 2117 AEEAEEARVQAEREAAQSRRQVEEAE-RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2175
Query: 1369 RQEAREELLLHQSEWEGRISPEQVDTSSLPLVPQHSFASLPLNESERNQEPCSINSDNIV 1428
R +A + L Q + + FA L + + ++ + +
Sbjct: 2176 RAQAEQAAL------------RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2223
Query: 1429 SSGHS------EIPTLPDGLLGLSHLVLPQQDNLIALEEHLHAQTDFLPSIEKTQKELVL 1482
+ H E+ L + ++ L ++ + + IE + L+L
Sbjct: 2224 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2283
Query: 1483 SKPCKFEEKVSSEHFIQSHHGDLQALQQQLDTQKKAIRSIQEVQEELLLQRLSELEKRVS 1542
+K +++ F+Q + ++ ++A R QE L++L+E + ++
Sbjct: 2284 ------RDKDNTQRFLQ------EEAEKMKQVAEEAARLSVAAQEAARLRQLAEED--LA 2329
Query: 1543 SEQVCSSSFVSQVPVADSERTQKSFPTKSNDTLPSSHREIPRLQDRLLSLSKPILPQQ-- 1600
++ + + + A E T+ K+ L +E+ + Q R L K + QQ
Sbjct: 2330 QQRALAEKMLKEKMQAVQEATR----LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2385
Query: 1601 ---DNMTAQLDAQREVMYSYEKPQEELSLNKQRKLNKSESAEHTIPSLFLPKETEHSFIP 1657
L+A+R+ E L L AE K+ E
Sbjct: 2386 EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF--RKQAEEIGEK 2443
Query: 1658 LPFAEAKPKS------TCELYSSQNEHAAPPSNPVIPGFQDRLLSFSQS-----VLTQQD 1706
L E + T E+ Q++H A I + Q + +++
Sbjct: 2444 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2503
Query: 1707 NLGLQKQLDLQREVLHYSQKAQEKLLVQRQTALQQQIQKHEETLKDFFKDSQISKPTVEN 1766
Q+QL + + L S +++ L+QR+ ++Q+ K E+ +D +Q + E
Sbjct: 2504 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE--EQ 2561
Query: 1767 DLKTQKMGQLRDWFPNTQDLAGNDQENIRHADRNNSDD 1804
+ Q+M Q R + + A Q R ++
Sbjct: 2562 QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE 2599
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 73.6 bits (179), Expect = 2e-12
Identities = 213/1131 (18%), Positives = 432/1131 (38%), Gaps = 125/1131 (11%)
Query: 26 YERRRKLRLLQVREQERDIALQIREDIKQRRNQQFTRLAEELRAEWEESQTQKIQNLEKL 85
+E +R+L L+ R ++ + Q K+ + L +++ A E++ K +KL
Sbjct: 914 FEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKL 973
Query: 86 YLASLRSMGEGHRQAKENEPDLDALAQR--AAERKRKADLRHKEALKVQKNQKEILLKQK 143
A + Q +E DL L + AA R+ +A+ ++ ++Q+ Q+E+L + +
Sbjct: 974 VQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQS-QLQREQEELLARLE 1032
Query: 144 TWHIKARKEALLVEKERSAKITSLPPPPPTLFENIEVKRISAVKTNSSTYHHLHTFVNRE 203
+ +E +++ER + E ++ + + T H L T ++ E
Sbjct: 1033 AEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLAT-ISLE 1091
Query: 204 TDTKRPDARLAAEEEAKRLEELQKQAAQERMERFEKA-----HVRGFQAMKKIHLAQNQE 258
+ ++ DA+ E++ + L + R +R E A VR Q + L + ++
Sbjct: 1092 MERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQAR-DLGKQRD 1150
Query: 259 KLMKELKQLQQEDLARRRQTVAQMPPQLVELPYKRSEMKEDWQRELEFAFEDMYNADRKV 318
++E ++L+ + L + +L+E K E +E + + + A E +
Sbjct: 1151 SCLREAEELRTQ-LRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGA 1209
Query: 319 KGNLILHLEPEPLPTVTNQIQDEELDLSMEQENLGAAEDLPVTEAEICSSETDVPLVMKT 378
K L E L + + + E + L + E+ L + EA + L
Sbjct: 1210 KEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLAL-LEEARTAVGKEAGELRTGL 1268
Query: 379 QQIP-SKVLFKKLLNKIRSQKSLWTIKSMSEDESEMITTVSEIESKAPTVESGTIASKER 437
Q++ S++ ++ L ++R Q +K + + + + ++E++ + E S+
Sbjct: 1269 QEVERSRLEARRELQELRRQ-----MKMLDSENTRLGRELAELQGRLALGERAEKESRRE 1323
Query: 438 TLS--------------SGQEQVVESDTLTIESGPLASEDKPLSCGTNSGKEQEINET-- 481
TL QE V L + G + ++ L + E +
Sbjct: 1324 TLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDH 1383
Query: 482 -----LPITTVAQSSVLLHPQEAAARIRMSARQKQIMEIEEQK---QKQLELLEQIEQQK 533
L + + L + +AA R + ++ +E Q+ + QL L ++
Sbjct: 1384 ARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRG 1443
Query: 534 LRLE------------TDCFRAQLEEEKRKKTQPTGVGIAPASCPVI-------SDEDSH 574
L L + A E P+ + +P S P + D
Sbjct: 1444 LGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLD 1503
Query: 575 RQMIRNYQHQLLQQNRLHRQSVETARKQLLEYQTMLKGRCPSVSAPSLITDSVISVPSWK 634
+ +R + LQ+ R S + R +L + L + + A DS S + +
Sbjct: 1504 PEAVRGALREFLQELR----SAQRERDELRTQTSALNRQLAEMEAER---DSATS-RARQ 1555
Query: 635 SERPTAISEHWDQGQRLKLSPNKYQ-PIQPIQTSKLEQDHFQVARQNHFPQRQVETTET- 692
++ A SE + +LS + + +Q + E++ Q +R ++ TE+
Sbjct: 1556 LQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESE 1615
Query: 693 LRASDILTNQALESQEHLRQFSQTETQ----QRDYKLVPKDSETLSRALSHDRQLISQDA 748
LRAS QE + + ET+ +R K V SE+ + L R+ + +
Sbjct: 1616 LRAS----------QEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGEL 1665
Query: 749 RKISETFGATTFQSLESQQLFSENSENISYHLTEPSSFVPLVPQHSFSSLPVKVESGKIQ 808
++ Q+ Q ++ + + V + + + V+ G ++
Sbjct: 1666 QRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALR 1725
Query: 809 EPFSAMSKSTVSTSHSIISQMHDRPLLPSENITAQQGNMKALQEQLDLQKKVLQATQEAQ 868
+ ++++ +S S+ S D+ L + +TA + + + LQE+LD ++ L ++
Sbjct: 1726 DKVRGLTEALAQSSASLNST-RDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQS 1784
Query: 869 EQLLLCKQKEVEQQTGLSVFLPLVTPDSSALLPSAKADLGRIQESSPTKNNIAVSSDHHV 928
L ++V+ G L L ++ L + L + QE N
Sbjct: 1785 SSL----GEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALN--------T 1832
Query: 929 ISQLQDKRLSLSQPILSQQNNFKFLQEQ--------LNIQKDSLQARREAQEVLYVHKQS 980
+ +LQD+R L + + S Q L+ + L ++KD + RR +V +S
Sbjct: 1833 VQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRS 1892
Query: 981 ELDR-RVCSEQAEPSFPFQVAQHTFTSLPSADTKSGKIQEQHSSKSEKGLVSCQSDIPIS 1039
D R+ +E+ +L A+ + + Q Q + +V QS P
Sbjct: 1893 HEDTVRLSAEKGRLD----------RTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQ 1942
Query: 1040 QDGSLSFLQQFLPLHDSLKLLQEQLTKQRDTLQARHEAQVELLLHRQRDLG 1090
+ + QQ L L ++ L+ + TL+AR A HRQR G
Sbjct: 1943 LE--VDAQQQQLELQQEVERLRSAQAQTERTLEARERA------HRQRVRG 1985
Score = 55.1 bits (131), Expect = 9e-07
Identities = 284/1509 (18%), Positives = 556/1509 (36%), Gaps = 215/1509 (14%)
Query: 430 GTIASKERTLSSGQEQVVESDTLTIESGPLASEDKPLSCGTNSGKEQEINETLPITTVAQ 489
G + + L + ++Q+ +S++ E L + + L T+ + + + +
Sbjct: 540 GRYEASQDLLGTLRKQLSDSES---ERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRS 596
Query: 490 SSVLLHPQEAAARIRMSARQKQIMEIEEQKQKQLELLEQIEQQKLRLETD---------C 540
++ LL +++ + Q+Q E+ ++++K E++ +Q+ RLE +
Sbjct: 597 ANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGAR 656
Query: 541 FRAQLEEEKRKKTQPTGVGIAPASCPVISDEDSHRQMIRNYQHQLLQQNRLH-RQSVETA 599
R +LE R+ Q G A V E R + Q +LQ + +++ A
Sbjct: 657 VRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATL---QRDMLQAEKAEVAEALTKA 713
Query: 600 RKQLLEYQ-TMLKGRCPSVSAPSLITDSVISVPSWKSERPTAISEHWDQGQRLKLSPNKY 658
+E + +M K R S + DS+ + +A++E Q KL N+
Sbjct: 714 EAGRVELELSMTKLRAEEAS----LQDSL--------SKLSALNESLAQD---KLDLNRL 758
Query: 659 QPIQPIQTSKLEQDHFQVARQNHFPQRQVETTETLRASDILTNQALE--------SQEHL 710
+ S L+ Q ++ + + E E LR + Q LE +QE L
Sbjct: 759 VAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEAL 818
Query: 711 RQFSQTETQQRDYKLVPKDSETLSRALSHDRQLISQDARKISETFGATTFQSLESQQLFS 770
Q Q T + + + + LSR LS Q + Q R+ A + E + L
Sbjct: 819 EQ--QLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAK 876
Query: 771 EN---------SENISYHLTEPSSFVPLVP----------QHSFSSLPVKVESGKIQEPF 811
E+ +E L+E ++ + L Q + L + E + +
Sbjct: 877 EHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQA 936
Query: 812 SAMSKSTVSTSHSIISQM---------HDRPLLPSENITAQQGNMKALQEQLDLQKKVLQ 862
++K T++ + + Q D+ L+ + + A++ +L+EQ ++ LQ
Sbjct: 937 LLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQ 996
Query: 863 ATQEAQEQLLLCKQKEVE-QQTGLSVFLPLVTPDSSALLPSAKADLGR----IQESSPTK 917
Q +E +E+E ++ L L + A L + K +L +Q+
Sbjct: 997 RLQREKE----AAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEG 1052
Query: 918 NNIAVSSDHHVISQLQDKRLSLSQPILSQQNNFKFLQEQLNIQKDSLQARREAQEVLYVH 977
+A S +S + ++ +LS+ ++ +++ + ++ QK Q+R+E
Sbjct: 1053 LLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNA 1112
Query: 978 KQSEL-DRRVCSEQAEPSFPFQVAQHTFTSLPSADTKSGKIQEQHSSKSEKGLVSCQSDI 1036
SEL D R E+A + +V ++QEQ D+
Sbjct: 1113 LTSELRDLRAQREEAAAAHAQEVR---------------RLQEQ------------ARDL 1145
Query: 1037 PISQDGSLSFLQQFLPLHDSLKLLQEQLTKQRDTLQARHEAQVELLLHRQRDLGDSKSGL 1096
+D S L++ L L+LL++ RD L+ LL QR L +S+ G
Sbjct: 1146 GKQRD---SCLREAEELRTQLRLLED----ARDGLRRE-------LLEAQRKLRESQEGR 1191
Query: 1097 VSSSSSPVVVQHSVASQASAKAEPRRIQELYLSEKENVGPSCHLIIPTFQDKSLSFPQHS 1156
++ S+ A + RR E S + + + +S +
Sbjct: 1192 EVQRQEAGELRRSLGEGAKEREALRRSNEELRS-----------AVKKAESERISLKLAN 1240
Query: 1157 LAQQENLTILQE-QSQIQRVILGAKEGTQEFVHTESELEKRISSEQTGTSSSLSQVDESE 1215
+++ L +L+E ++ + + + G QE S LE R ++ + + +
Sbjct: 1241 EDKEQKLALLEEARTAVGKEAGELRTGLQEV--ERSRLEARRELQELRRQMKMLDSENTR 1298
Query: 1216 RFQECISIKSDSTIPLSHPKIPRCQERLLRVSQHMLPLQDNLEEHQAWLDTEKEAFHFSQ 1275
+E ++ + K R + L L+ L + +A L+ ++ +Q
Sbjct: 1299 LGRELAELQGRLALGERAEKESR---------RETLGLRQRLLKGEASLEVMRQELQVAQ 1349
Query: 1276 -KTQENTSSEQTGSSSFIPQLVQLSFTSLASAESGTILEPLFTESESKIFSSHLQIPQLQ 1334
K QE +T + L + T + LE + ++ L++ +
Sbjct: 1350 RKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAE 1409
Query: 1335 DRLLRISQLIQPQQDNLKALQEQLATQREAIILARQEAREELLLHQSEWEGRISPEQVDT 1394
R + + + +A + QL R A+ R L L ++
Sbjct: 1410 GRAQGLEAELARVEVQRRAAEAQLGGLRSAL-------RRGLGLGRA------------- 1449
Query: 1395 SSLPLVPQHSFASLPLNESERNQEPCSINSDNIVSSGHSEIPTLPDGLLGLSHLVLPQQD 1454
P P ++ +NS + + P P + L +
Sbjct: 1450 ---PSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEA 1506
Query: 1455 NLIALEEHLHAQTDFLPSIEKTQKELVLSKPCKFEEKVSSEHFIQSHHGDLQALQQQLDT 1514
AL E L L S ++ + EL + E S + LQ+ +
Sbjct: 1507 VRGALREFLQE----LRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAE 1562
Query: 1515 QKKAIRSI----QEVQEELLLQ----RLSELEKRVSSEQVCSSSFVSQVPVADSERTQ-K 1565
++A RS+ VQ EL LQ R SE E+R + +QV + Q ++ +Q K
Sbjct: 1563 SEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEK 1622
Query: 1566 SFPTKSNDT-LPSSHREIPRLQDRLLSLSKPILPQQDNMTAQLDAQREVMYSYEKPQEEL 1624
K+N+T L R + + D S + + Q+ ++ +L QR + ++ +
Sbjct: 1623 ISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGEL--QRSRLGLSDREAQAQ 1680
Query: 1625 SLNKQRKLNKSESAEHTIPSLFLPKETEHSFIPLPFAEAKPKSTCELYSSQNEHAAPPSN 1684
+L + + + A+ + + L E L E + + E A S+
Sbjct: 1681 ALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTE-ALAQSS 1739
Query: 1685 PVIPGFQDRLLSFSQSVLT-QQDNLGLQKQLDLQREVLHYSQKAQEKLLVQRQT----AL 1739
+ +D+ L +++ + D LQ++LD R+ L ++K L Q QT
Sbjct: 1740 ASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVA 1799
Query: 1740 QQQIQKHE-----ETLKDFFKDSQISKPTVENDLKTQKMGQLRDWFPNTQDLAGNDQENI 1794
++Q+ E + L++ + Q + N ++ +L+D Q+ G+ Q +
Sbjct: 1800 DLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQ-----KLQDERRLLQERLGSLQRAL 1854
Query: 1795 RHADRNNSDDNHLASEDTSAKQSGEHLEKD-LGRRSSKPPVAKVKCGLDLNQHELSAIQE 1853
L +E ++S LEKD + R + V + K L HE +
Sbjct: 1855 A----------QLEAEKREVERSALRLEKDRVALRRTLDKVEREK----LRSHEDTVRLS 1900
Query: 1854 VESPAIGRT 1862
E + RT
Sbjct: 1901 AEKGRLDRT 1909
Score = 54.3 bits (129), Expect = 2e-06
Identities = 124/635 (19%), Positives = 247/635 (38%), Gaps = 88/635 (13%)
Query: 17 EEAFILKEDYERRRKLRLLQ-VREQERDIALQIREDIKQRRNQQFTRLAEELRAEWEESQ 75
+EA + +E+ ER +LRL Q V Q + +L++ E ++ QQ L E R++ +E
Sbjct: 778 QEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHE-RSQLQEQL 836
Query: 76 TQ-------KIQNLEKLYLASLRSMGEGHRQAKENEPDLDALAQR---------AAERKR 119
Q + Q LE+ + R + R A+E E ALA+ AAER+
Sbjct: 837 AQLSRQLSGREQELEQARREAQRQVEALERAAREKE----ALAKEHAGLAVQLVAAEREG 892
Query: 120 KADLRHKEALKVQKNQKE---ILLKQKTWHIKARKEALLVEKERSAKITSLPPPPPTLFE 176
+ L+++K E ++++ ++AR+E L E + +L TL
Sbjct: 893 RTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQ------ALLLAKETLTG 946
Query: 177 NIEVKRISAVKTNSSTYHHLHTFVNRETDTKRPDARLAAEEEAKRLEELQKQAAQERMER 236
+ R + T + +R E+ A E+LQ R++R
Sbjct: 947 ELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQ------RLQR 1000
Query: 237 FEKAHVRGFQAMKKIHLAQNQEKLMKELKQLQQEDLARRRQTVAQMPPQLVELPYKRSE- 295
++A R +A + AQ Q +L +E Q+E LAR ++ ++ L +R E
Sbjct: 1001 EKEAAWRELEAER----AQLQSQLQRE----QEELLARLEAEKEELSEEIAALQQERDEG 1052
Query: 296 ---MKEDWQRELEFAFEDMYNADRKVKGNLILHLEPEPLPTVTNQIQDEELDLSMEQENL 352
+ + Q+ L + K+ G L T++ +++ ++ D QE
Sbjct: 1053 LLLAESEKQQALSLKESEKTALSEKLMGT------RHSLATISLEMERQKRDAQSRQEQD 1106
Query: 353 GAAEDLPVTEAEICSSETDVPLVMKTQQI-----PSKVLFKKLLNKIRSQKSLWTIKSMS 407
+ + +E ++ + Q++ ++ L K+ + +R + L T +
Sbjct: 1107 RSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLL 1166
Query: 408 EDESE-MITTVSEIESKAPTVESGTIASKE------RTLSSGQEQVVESDTLTIESGPLA 460
ED + + + E + K + G ++ R+L G + E L
Sbjct: 1167 EDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAK----------EREALR 1216
Query: 461 SEDKPLSCGTNSGKEQEINETLPITTVAQSSVLLHPQEAAARIRMSARQKQIMEIEEQKQ 520
++ L + + I+ L Q LL A + + E+E +
Sbjct: 1217 RSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRL 1276
Query: 521 KQLELLEQIEQQKLRLETDCFRAQLEEEKRKKTQPTGVGIAPASCPVISDEDSHRQMIRN 580
+ L+++ +Q L+++ R E + + G ++++S R+ +
Sbjct: 1277 EARRELQELRRQMKMLDSENTRLGRELAELQGRLALGER---------AEKESRRETLGL 1327
Query: 581 YQHQLLQQNRLH--RQSVETARKQLLEYQTMLKGR 613
Q L + L RQ ++ A+++L E + + R
Sbjct: 1328 RQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTR 1362
Score = 44.7 bits (104), Expect = 0.001
Identities = 247/1298 (19%), Positives = 496/1298 (38%), Gaps = 244/1298 (18%)
Query: 404 KSMSEDESEMITTVSEIESKAPTVESGTIASKERTLSSGQEQVVES----DTLTIESGPL 459
+++S+ ES ++ +E+ S E + +E LS ++ + +S D L I+ +
Sbjct: 57 RNLSQPESPVLLPATEMASLLSLQEENQLLQQE--LSRVEDLLAQSRAERDELAIKYNAV 114
Query: 460 ASE-DKPLSCGTNSGKEQEINETLPITTVAQSSVL---LHPQEAAARIRMSARQKQIMEI 515
+ ++ L + QE P V QS L L ++A+ R ++ A Q
Sbjct: 115 SERLEQALRLEPGELETQE-----PRGLVRQSVELRRQLQEEQASYRRKLQAYQ------ 163
Query: 516 EEQKQKQLELLEQIEQQKLRLETDCFRAQLEEEKRKKTQPTGVGIAPASCPVISDEDSHR 575
E +Q+Q +L+++++ + L+ + C ++LE++ +++ + +
Sbjct: 164 -EGQQRQAQLVQRLQGKILQYKKRC--SELEQQLLERSG-----------------ELEQ 203
Query: 576 QMIRNYQHQLLQQNRLHRQSVETARK-QLLEYQTMLKGRCPSV-SAPSLITDSVISVPS- 632
Q +R+ +H ++ L R E R L + ML+ + SA +++ + V +
Sbjct: 204 QRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQALSEDIRKVTND 263
Query: 633 --------------WKSERPTAISEHWDQGQRLKLSPNKYQPIQPIQTSK---LEQDHFQ 675
W+ E + + ++ RL L + + + + E+D Q
Sbjct: 264 WTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQ 323
Query: 676 VARQNHFPQRQVET-----TETLRASDILTNQALESQEHLRQFSQTETQQRDYKLVPKDS 730
+ + R V+ + LR ++ ALE Q L+ +Q E Q RD L KD
Sbjct: 324 LGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQ--AQLEEQLRDKVLREKDL 381
Query: 731 ETLSRALSHDRQLISQDARKISETFGATTFQSLESQQLFSENSENISYHLTEPSSFVPLV 790
D+ +S ++ Q+LE Q+ + +E + E + L
Sbjct: 382 AQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKL-----EALESLRLQ 436
Query: 791 PQHSFSSLPVKVESGK-IQEPFSAMSKSTVSTSHSIISQMHDRPLLPSENIT-AQQGNMK 848
Q + ++ E G+ +Q+ ++++ +S S S + L SE A G+++
Sbjct: 437 EQAA-----LETEDGEGLQQTLRDLAQAVLSDSESGVQ------LSGSERTADASNGSLR 485
Query: 849 ALQEQLDLQKKVLQATQEAQEQLLLCKQKEVEQQTGLSVFLPLVTPDSSALLPSAKADLG 908
L Q + + + G S DSS L
Sbjct: 486 GLSGQRTPSPPRRSSPGRGRSP-----------RRGPSP----ACSDSSTLA-------- 522
Query: 909 RIQESSPTKNNIAVSSDHHVISQLQDKRLSLSQPILSQQNNFKFLQEQLNIQKD----SL 964
+ S+ K + V QD +L + + ++ + L+EQL +D ++
Sbjct: 523 -LIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAM 581
Query: 965 QARREAQ-EVLYVHKQSELDRRVCSEQAEPSFPFQVAQHTFTSLPSADTKSGKIQE---- 1019
QA +AQ EV + +EL R E++ + QVAQ L K QE
Sbjct: 582 QAHEDAQREVQRLRSANELLSR---EKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRR 638
Query: 1020 QHSSKSEKGLVSCQSDIPISQDGSLSFLQQFLPLHDSLKLLQEQLTKQRDTLQARHEAQV 1079
Q E+ + Q + ++ S +Q L +L ++L + R+ L +R Q
Sbjct: 639 QRDRLEEEQEDAVQDGARVRRELERSH-RQLEQLEGKRSVLAKELVEVREAL-SRATLQR 696
Query: 1080 ELLLHRQRDLGDS----KSGLVSSSSSPVVVQHSVASQASAKAEPRRIQELYLSEKENVG 1135
++L + ++ ++ ++G V S ++ AS + ++ + E +K ++
Sbjct: 697 DMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLN 756
Query: 1136 PSCHLIIPTFQDKSLSFPQHSLAQQENLTILQEQSQIQ-----------------RVILG 1178
L+ ++KS + A+QE +EQ +++ RV
Sbjct: 757 ---RLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQ 813
Query: 1179 AKEGTQEFV----HTESELEKRI---SSEQTGTSSSLSQVD-ESERFQECI--SIKSDST 1228
A+E ++ + H S+L++++ S + +G L Q E++R E + + +
Sbjct: 814 AQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEA 873
Query: 1229 IPLSHPKIP--------------------RCQERLLRVSQHMLPLQ-DNLEEHQAWLDTE 1267
+ H + R ++ L S + Q LE + L+ E
Sbjct: 874 LAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAE 933
Query: 1268 KEAFHFSQKT---------QENTSSEQTGSSS---FIPQLVQLSFTSLAS-----AESGT 1310
+A +++T Q+ ++++ S +LVQ + AS A
Sbjct: 934 GQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEE 993
Query: 1311 ILEPLFTESESKIFSSHLQIPQLQDRLLRISQLIQPQQDNLKALQEQLATQREAIILARQ 1370
L+ L E E+ + QLQ SQL + Q++ L L+ + E I +Q
Sbjct: 994 DLQRLQREKEAAWRELEAERAQLQ------SQLQREQEELLARLEAEKEELSEEIAALQQ 1047
Query: 1371 EAREELLLHQSEWEGRISPEQVDTSSLP---LVPQHSFASLPLN--------ESERNQEP 1419
E E LLL +SE + +S ++ + ++L + +HS A++ L +S + Q+
Sbjct: 1048 ERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDR 1107
Query: 1420 CSINS------------DNIVSSGHSEIPTLPDGLLGLSHLVLPQQDNLIALEEHLHAQT 1467
++N+ + ++ E+ L + L Q+D+ + E L Q
Sbjct: 1108 STVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLG----KQRDSCLREAEELRTQL 1163
Query: 1468 DFLPSIEKTQKELVLSKPCKFEEKVSSEHFIQSHHGDLQALQQQLDTQKKAIRSIQEVQE 1527
L + +L K E + G+L+ + +++A+R E
Sbjct: 1164 RLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNE--- 1220
Query: 1528 ELLLQRLSELEKRVSSEQVCSSSFVSQVPVADSERTQK 1565
L K+ SE++ + +A+ ++ QK
Sbjct: 1221 -----ELRSAVKKAESERI-------SLKLANEDKEQK 1246
Score = 42.4 bits (98), Expect = 0.006
Identities = 74/332 (22%), Positives = 140/332 (42%), Gaps = 25/332 (7%)
Query: 1060 LQEQLTKQRDTLQARHEAQVELLLHR----QRDLGDSKSGLVSSSSSPVVVQHSVASQAS 1115
L+ +L + R L R EAQ + L R QR + DS+ V + + + V+ + A
Sbjct: 1661 LEGELQRSRLGLSDR-EAQAQALQDRVDSLQRQVADSE---VKAGTLQLTVERLNGALAK 1716
Query: 1116 AKAEPRRIQELYLSEKENVGPSCHLIIPTFQDKSLSFPQHSLAQQENLTILQEQSQIQRV 1175
+ +++ E + S + T +DK+L + A + + +LQE+ R
Sbjct: 1717 VEESEGALRDKVRGLTEALAQSSASLNST-RDKNLHLQKALTACEHDRQVLQERLDAARQ 1775
Query: 1176 ILG-AKEGTQEFVHTESELEKRISS---EQTGTSSSLSQVDESERFQECISIKSDSTIPL 1231
L A++ + L ++ ++ L Q+ E R ++ + +T+
Sbjct: 1776 ALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQK 1835
Query: 1232 SHPKIPRCQERLLRVSQHMLPLQ-DNLEEHQAWLDTEKEAFHFSQKTQENTSSEQTGSSS 1290
+ QERL + + + L+ + E ++ L EK+ ++T + E+ S
Sbjct: 1836 LQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVAL-RRTLDKVEREKLRSHE 1894
Query: 1291 FIPQLVQLSFTSLASAESGTILEPLFTESESKIFSSHLQIPQLQDRLLRISQLIQPQQDN 1350
+L SAE G L+ T +E ++ + QI QL+ +++ + Q P Q
Sbjct: 1895 DTVRL---------SAEKGR-LDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLE 1944
Query: 1351 LKALQEQLATQREAIILARQEAREELLLHQSE 1382
+ A Q+QL Q+E L +A+ E L E
Sbjct: 1945 VDAQQQQLELQQEVERLRSAQAQTERTLEARE 1976
Score = 38.9 bits (89), Expect = 0.067
Identities = 80/367 (21%), Positives = 150/367 (40%), Gaps = 61/367 (16%)
Query: 14 SPNEEAFILKEDYERRRKLRLLQVREQERDIALQI---REDIKQRRNQQ------FTRLA 64
S ++A LKE + +L+ R I+L++ + D + R+ Q T
Sbjct: 1058 SEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSEL 1117
Query: 65 EELRAEWEESQTQKIQNLEKLYLASLRSMGEGH----RQAKENEPDLDALAQRAAERKRK 120
+LRA+ EE+ Q + +L R +G+ R+A+E L L + A + R+
Sbjct: 1118 RDLRAQREEAAAAHAQEVRRLQ-EQARDLGKQRDSCLREAEELRTQL-RLLEDARDGLRR 1175
Query: 121 ADLRHKEALKVQKNQKEILLKQKTWHIKARKEALLVEKERSAKITSLPPPPPTLFENIEV 180
L + L+ + +E+ Q+ + R+ KER A S N E+
Sbjct: 1176 ELLEAQRKLRESQEGREV---QRQEAGELRRSLGEGAKEREALRRS----------NEEL 1222
Query: 181 KRISAVKTNSSTYHHLHTFVNRETDTKRPDARLAAEEEAKRLEELQKQAAQERMERFEKA 240
+ SAVK + +++R +LA E++ ++L L++ E E
Sbjct: 1223 R--SAVK---------------KAESERISLKLANEDKEQKLALLEEARTAVGKEAGELR 1265
Query: 241 HVRGFQAMKKIHLAQNQE--KLMKELKQLQQEDLARRRQTVAQMPPQLVELPYKRSEMKE 298
G Q +++ L +E +L +++K L E+ R EL + +
Sbjct: 1266 --TGLQEVERSRLEARRELQELRRQMKMLDSENTRLGR-----------ELAELQGRLAL 1312
Query: 299 DWQRELEFAFEDMYNADRKVKGNLILHLEPEPLPTVTNQIQDEELDL-SMEQENLGAAED 357
+ E E E + R +KG L + + L ++Q++E + + E+ LG+ E+
Sbjct: 1313 GERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEE 1372
Query: 358 LPVTEAE 364
TE +
Sbjct: 1373 ARGTEKQ 1379
Score = 38.5 bits (88), Expect = 0.087
Identities = 48/246 (19%), Positives = 104/246 (42%), Gaps = 11/246 (4%)
Query: 21 ILKEDYERRRKLRLLQVREQERDIALQIREDIKQRRNQQFTRLAEELRAEWEESQTQKIQ 80
+L+E + R+ L + R+Q + Q++ + + + R+ E + + ++ Q
Sbjct: 1765 VLQERLDAARQA-LSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQ 1823
Query: 81 NLEKLYLASLRSMGEGHRQAKENEPDLD-ALAQRAAERKRKADLRHKEALKVQKNQ---K 136
E L +++ + + R +E L ALAQ AE++ + AL+++K++ +
Sbjct: 1824 EGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREV----ERSALRLEKDRVALR 1879
Query: 137 EILLKQKTWHIKARKEALLVEKERSAKITSLPPPPPTLFENIEVKRISAVKTNSSTYHHL 196
L K + +++ ++ + + E+ +L L E ++I ++
Sbjct: 1880 RTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAE--AQRQIQQLEAQVVVLEQS 1937
Query: 197 HTFVNRETDTKRPDARLAAEEEAKRLEELQKQAAQERMERFEKAHVRGFQAMKKIHLAQN 256
H+ E D ++ L E E R + Q + E ER + VRG + Q
Sbjct: 1938 HSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQL 1997
Query: 257 QEKLMK 262
Q++L +
Sbjct: 1998 QQELRR 2003
>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
Length = 1979
Score = 73.2 bits (178), Expect = 3e-12
Identities = 197/1117 (17%), Positives = 441/1117 (39%), Gaps = 109/1117 (9%)
Query: 21 ILKEDYERRRKLRLLQVREQERDIALQIREDIKQRRNQQFTRLAEELRAEWEESQTQKIQ 80
+L+E + + + L ALQ+ + + NQ+ EL+ E+ T +
Sbjct: 732 LLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKE 791
Query: 81 NLEKLYLASLRSMGEGHRQAKENEPDLDALAQRAAERKRKAD-----LRHKEALKVQKNQ 135
+ L +SL + + + E ++ L +R+++ + + D LR E L+ +
Sbjct: 792 TKDVLS-SSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEE 850
Query: 136 KEILL---KQKTWHIKARKEALLVEKERSAKITSLPPPPPTLFENIEVKRISAVKTNSST 192
K+ L K++ H++ E L E+ R+A + + K + +V +S
Sbjct: 851 KDRSLGSMKEENNHLQEELERLREEQSRTAPVA-------------DPKTLDSVTELASE 897
Query: 193 YHHLHTFVNRETDTKRPDARLAAEEEAKRLEELQK-QAAQERMERFEKAHVRGFQAMKKI 251
L+T + + ++ ++ +++ LQ Q ++ M+ F H + ++
Sbjct: 898 VSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQL 957
Query: 252 HLAQNQE--KLMKELKQLQQEDLARRRQTVAQMPPQLVELPYKRSEMKEDWQRELEFAFE 309
L +++E L K ++Q++ + L RQ + + + +S E+ + + +
Sbjct: 958 FLEKDEEIKSLQKTIEQIKTQ-LHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKA 1016
Query: 310 DMYNADRKVKG----NLILHLEPEPLPTVTNQIQDEELDLSMEQENLGAAEDLPVT--EA 363
+ +R VKG L + L E ++T QI D + + +DL + A
Sbjct: 1017 E---TERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHA 1073
Query: 364 EICSSETDVPLVMKTQQIPSKVLFKKLLNKIRSQKSLWTIKSMSEDESEMITTVSEIESK 423
I S+ +V QQ+ + + ++ + + ++K+ + + +M+ V+ E+
Sbjct: 1074 RISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTREN-SHLKTEYHKMMDIVAAKEAA 1132
Query: 424 APTVESGTIASKERTLSSGQEQVVESDTLTIESGPLASEDKPLSCGTNSGKEQEINETLP 483
++ R SSGQ+ E TI++ +K + S K Q + L
Sbjct: 1133 LIKLQDENKKLSTRFESSGQDMFRE----TIQNLSRIIREKDIEIDALSQKCQTLLAVLQ 1188
Query: 484 ITTVAQSSVLLHPQEAAARIRMSARQKQ-IMEIEEQKQKQLELLEQIEQQKLRLETDCFR 542
++ + ++ + ++ + KQ + ++EE KQ+ + ++ ++ + +L+ + +
Sbjct: 1189 TSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQ 1248
Query: 543 AQ----LEEEKRKKTQPTGVGIAPASCPVISDEDSHRQMIRNYQHQLLQQNRLHRQSVET 598
Q ++ + K Q G+ I + + ++N+ +L Q V+
Sbjct: 1249 LQAQVLVDSDNNSKLQVDYTGL-------IQSYEQNETKLKNFGQELAQ--------VQH 1293
Query: 599 ARKQLLEYQTMLKGR----CPSVSAPSLITDSVISVPSWKSERPTAISEHWDQGQRLKLS 654
+ QL + +L G+ P +S+ SL+T S ++ + +SE + Q
Sbjct: 1294 SIGQLCNTKDLLLGKLDIISPQLSSASLLTPQ--SAECLRASKSEVLSESSELLQ----- 1346
Query: 655 PNKYQPIQPIQTSKLEQDHF--QVARQNHFPQRQVETTETL-RASDILTNQALESQEHLR 711
Q ++ ++ S E+D + NH + T L R T+ ++ + +
Sbjct: 1347 ----QELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQ 1402
Query: 712 QFSQTETQQRDYKLVPKDSETLSRALS-----HDRQLISQDARKISETFGATTFQSLESQ 766
Q +++D + K + LS + ++ +L+ Q + E ++
Sbjct: 1403 DVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERI---LILEMDIG 1459
Query: 767 QLFSENSENISYHLTEPSSFVPLVPQHSFSSLPVKVESGKIQEPFSAMSKSTVSTSHSII 826
+L EN + + + + + + L + FS M + HS+
Sbjct: 1460 KLKGENEKIVETYRGKETEYQAL---------------QETNMKFSMMLREKEFECHSMK 1504
Query: 827 SQMHDRPLLPSENITAQQGNMKALQEQL-DLQKKVLQATQEAQEQLLLCKQKEVEQQTGL 885
+ L E + G + L + +Q+K + QE + +L KQK++E T L
Sbjct: 1505 EKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQME-NTAL 1563
Query: 886 SVFLPLVTPDSSALLPSAKADLGRIQESSPTKNNIAVSSDHHVISQLQDKRLSLSQPILS 945
+ + + + ES + A++++ ++L+ K L + ++S
Sbjct: 1564 QNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAEDRE-AKLRKKVTVLEEKLVS 1622
Query: 946 QQNNFKFLQEQLNIQKDSLQARREAQEVLYVHKQSELDRRVCSEQAEPSFPFQVAQHTFT 1005
N + Q ++Q +SLQ +++ V KQ + S E + ++
Sbjct: 1623 SSNAMENASHQASVQVESLQ-----EQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQ 1677
Query: 1006 SLPSADTKSGKIQEQHSSKSEKGLVSCQSDIPISQDGSLSFLQQFLPLHDSLKLLQEQLT 1065
+ + K + +K L++ + +G + LQ+ L ++ +LT
Sbjct: 1678 MVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECLDEANAALDSASRLT 1737
Query: 1066 KQRDTLQARHEAQVELLLHRQRDLGDSKSGLVSSSSS 1102
+Q D + + E RQ L D + L+S ++S
Sbjct: 1738 EQLDVKEEQIEELKRQNELRQEMLDDVQKKLMSLANS 1774
Score = 51.6 bits (122), Expect = 1e-05
Identities = 205/1054 (19%), Positives = 411/1054 (38%), Gaps = 148/1054 (14%)
Query: 1014 SGKIQEQHSSKSEKGLVSCQSDIPISQDGSLSFLQQFLPLHDSLKLLQEQLTKQRDTLQA 1073
+G+I +G ++++P S+ + +H L+ E+L K L+
Sbjct: 27 TGQISNFTKDMLMEGTEEVEAELPDSRTKEIE------AIHAILRSENERLKKLCTDLEE 80
Query: 1074 RHEAQVELLLHRQRDLGDSKSGLVSSSSSPVVVQHSVASQASAKAEPRRIQELYLSEKEN 1133
+HEA E+ + +Q S S V + H A Q + + + ++Q S
Sbjct: 81 KHEAS-EIQIKQQ-----STSYRNQLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSG 134
Query: 1134 VGPSCHLIIPTFQDKSLSFPQHSLAQQENLT----ILQEQSQIQRVILGAKEGTQEFVHT 1189
G +F + H A ++ I+ Q +I R+ + E
Sbjct: 135 AGVPATTASSSF---AYGISHHPSAFHDDDMDFGDIISSQQEINRL-------SNEVSRL 184
Query: 1190 ESELEKRISSEQTGTSSSLSQVDESERFQECISIKSDSTIPLSHPKIPRCQERLLRVSQH 1249
ESE+ QT + D+SE I + Q + + Q+
Sbjct: 185 ESEVGHWRHIAQTSKAQGTDNSDQSE--------------------ICKLQNIIKELKQN 224
Query: 1250 MLPLQDNLEEHQAWLDTEKEAFHFSQKTQENTSSEQTGSSSFIPQLVQLSFTSLASAESG 1309
+++HQ + + A QK E + + S + ++ +L L SG
Sbjct: 225 R---SQEIDDHQHEMSVLQNAHQ--QKLTEISRRHREELSDYEERIEELE-NLLQQGGSG 278
Query: 1310 TILEPLFTESESKIFSSHLQIPQLQDRLLRISQLIQPQQDNLKALQEQLATQREAIILAR 1369
I L SKI+ I LQ + ++ ++ +D +K + ++L++ + R
Sbjct: 279 VIETDL-----SKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILR 333
Query: 1370 QEAREELLLHQSEWEGRISPEQVDTSSLPLVPQHSFASLPLNESERN-QEPCSINS---- 1424
+E +E+L + + + +++ S L P S + E ER + S+
Sbjct: 334 RE-QEQLNVEKRQIMEECENLKLECSKLQ--PSAVKQSDTMTEKERILAQSASVEEVFRL 390
Query: 1425 DNIVSSGHSEIPTLP----DGLLGLSHLVLPQQDNLIALEEHLHAQT--DFLPSIEKTQK 1478
+S +EI L D L +L L + ++ E+ L +Q + S+ K
Sbjct: 391 QQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNN 450
Query: 1479 ELVLSKPCKFEEKVSSEHFIQSHHGDLQALQQQLDTQKKAIRSIQEVQEELLLQRLSELE 1538
E + K + +S + + +L+A +Q+L+ +SI E +E L+ + EL+
Sbjct: 451 EYEVIKSTATRD-ISLDSELHDLRLNLEAKEQELN------QSISE--KETLIAEIEELD 501
Query: 1539 KRVSSEQVCSSSFVSQVPVADSERTQKSFPTKSNDTLPSSHREIPRLQDRLLSLSKPILP 1598
++ +++ + + ++ + S +K L + + +L+D + ++K
Sbjct: 502 RQ--NQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITK---- 555
Query: 1599 QQDNMTAQLDAQREVMYSYEKPQEELSLNKQRKLNKSESAEHTIPSLFLPKETEHSFIP- 1657
+LD Q+E + E +L L KQ+ +K E+ + L +E+ S
Sbjct: 556 -------ELDVQKEKLIQSEVALNDLHLTKQKLEDK---VENLVDQLNKSQESNVSIQKE 605
Query: 1658 -LPFAEAKPKSTCELYSSQNEHAAPPSNPVIPGFQDRLLSFSQS-VLTQQDNLGLQKQLD 1715
L E ++ EL +NE + F+D LL ++ V + NL +QL+
Sbjct: 606 NLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLN 665
Query: 1716 LQREVLHYSQKAQEKLLVQRQTALQQQIQKHEETLKDFFKDSQIS--KPTVENDLKTQKM 1773
+ + + K + + LV ++ Q+ EE L ++Q+S K T+ LK +K
Sbjct: 666 ENLKKVAFDVKMENEKLVLACEDVRHQL---EECLAG---NNQLSLEKNTIVETLKMEK- 718
Query: 1774 GQLRDWFPNTQDLAGNDQENIRHADRNNSDDNHLASE---DTSAKQ-SGEHLEKDLGRRS 1829
G++ +L + + A++ L++ +TSA Q EHL K ++
Sbjct: 719 GEIE------AELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKD 772
Query: 1830 SKPPVAKVKCGLDLNQHELSAIQEVESPAIGR----TSILGKPGIYEDRDPLRVSISREQ 1885
+ +A++K ++ + ++V S ++ T ++ K I+ ++ R S +E+
Sbjct: 773 ME--IAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEE 830
Query: 1886 SFFGSPLAHDPFSCLQLVGQENVCGDDYDEAVKLKESVVENHAVLSYAVE---EEHAYLG 1942
D +S Q + + + +E + S+ E + L +E EE +
Sbjct: 831 L--------DKYS--QALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTA 880
Query: 1943 PTVKPDDKAKTLSYEPLSSATVSTGSLLSYENTDLSLTDPESFSEHMDDSKQESTTSKEE 2002
P P KTL ++ VS + + E+ + + + E + SK + S +E
Sbjct: 881 PVADP----KTLDSVTELASEVSQLNTIK-EHLEEEIKHHQKIIEDQNQSKMQLLQSLQE 935
Query: 2003 ETNIISSIVPSTQDIYQRQNSSDVHKSLLPAVDE 2036
+ + YQ + + H L DE
Sbjct: 936 QKKEMDEF------RYQHEQMNATHTQLFLEKDE 963
Score = 50.4 bits (119), Expect = 2e-05
Identities = 283/1480 (19%), Positives = 551/1480 (37%), Gaps = 243/1480 (16%)
Query: 1 MKRKVVNTHKLRLSPNEEAFI-----LKEDYE--RRRKLRLLQVREQERDIALQIREDIK 53
M+ +V+ K LS +E L +YE + R + + + D+ L + E +
Sbjct: 422 MRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNL-EAKE 480
Query: 54 QRRNQQFTRLAEELRAEWEESQTQKIQNLEKLYLASLRSMGEGHRQAKENEPDLDALAQR 113
Q NQ + E L AE EE Q + + + L + +Q E + + L Q
Sbjct: 481 QELNQSISE-KETLIAEIEELDRQNQEATKHMILIK----DQLSKQQNEGDSIISKLKQD 535
Query: 114 AAERKRKADLRHKEALKVQKN---QKEILLKQKT----WHIKARKEALLVEKERSAKITS 166
+ K++ + + + K QKE L++ + H+ +K VE S
Sbjct: 536 LNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKS 595
Query: 167 LPPPPPTLFENIEVKRISAVKTN----SSTYHHLHTFVNRETDTKRPDARLAAEEEAKRL 222
EN+E+K ++ N S + L +N+++++ D L E R
Sbjct: 596 QESNVSIQKENLELKE--HIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRN 653
Query: 223 EELQKQAAQERMERFEKAHVRGFQAMKKIHLAQNQEKLMKELKQLQQEDLARRRQTVAQM 282
+ ++ E +K +K+ LA ++++ +E LA Q +
Sbjct: 654 LKQNLSELEQLNENLKKVAFDVKMENEKLVLA------CEDVRHQLEECLAGNNQLSLEK 707
Query: 283 PPQLVELPYKRSEMKEDWQRELEFAFEDMYNADRKVKGNLILHLEPEPLPTVTNQIQDEE 342
+ L ++ E+ + EL +A + + K + + L T Q++ E
Sbjct: 708 NTIVETLKMEKGEI----EAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEH 763
Query: 343 LDLSMEQENLGAAEDLPVTEAEICSSETDVPLVMKTQQIPSKVLFKKLLNKIRSQKSLWT 402
L L +D+ + E + + D + S + +K L ++ ++K ++
Sbjct: 764 LI------KLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFI 817
Query: 403 --IKSMSEDESEMITTVSEIESKAPTVESGTIASKERTLSSGQEQVVESDTLTIESGPLA 460
+K S E + S+ K + TI K+R+L S +E E+ L
Sbjct: 818 EKLKERSSKLQEELDKYSQALRKNEILRQ-TIEEKDRSLGSMKE----------ENNHLQ 866
Query: 461 SEDKPLSCGTNSGKEQEINETLPITTVAQSSVLLHPQEAAARIRMSARQKQIME------ 514
E + L +E + T P VA L E A+ + K+ +E
Sbjct: 867 EELERL--------REEQSRTAP---VADPKTLDSVTELASEVSQLNTIKEHLEEEIKHH 915
Query: 515 ---IEEQKQKQLELLEQIEQQKLRLETDCFRAQLEEEKRKKTQPTGVGIAPASCPVISDE 571
IE+Q Q +++LL+ +++QK E D FR Q E+ TQ + ++
Sbjct: 916 QKIIEDQNQSKMQLLQSLQEQK--KEMDEFRYQHEQMNATHTQ------------LFLEK 961
Query: 572 DSHRQMIRNYQHQLLQQNRLHRQSVETARKQLLEYQTMLKGRCPSVSAPSLITDSVISVP 631
D + ++ Q+ Q RQ ++T + + + + S ++
Sbjct: 962 DEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLS------- 1014
Query: 632 SWKSERPTAISEHWDQGQRLKLSPNKYQPIQPIQTSKLEQDHFQVARQNHFPQRQVETTE 691
K+E + ++ +KL K + Q +L +D +V + Q++ +
Sbjct: 1015 --KAETERLVKGIKERELEIKLLNEKNISLTK-QIDQLSKD--EVGKLTQIIQQKDLEIQ 1069
Query: 692 TLRA---SDILTNQALESQEHLRQFSQ---------TETQQRDYKLVPKDSETLSRALSH 739
L A S T + Q+ L+ ++ E + + L + + + +
Sbjct: 1070 ALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAK 1129
Query: 740 DRQLIS-QDARKISETFGATTFQSLESQQLFSENSENISYHLTEPSSFVPLVPQHSFSSL 798
+ LI QD K +T F+S Q +F E +N+S + E +
Sbjct: 1130 EAALIKLQDENKKL----STRFES-SGQDMFRETIQNLSRIIRE-------------KDI 1171
Query: 799 PVKVESGKIQEPFSAMSKSTVSTSHSIISQMHDRPLLPSENITAQQGNMKALQEQLDLQK 858
+ S K Q + + S+ ++ LL + QQ +K ++E
Sbjct: 1172 EIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQ--VKKMEEWKQQVM 1229
Query: 859 KVLQATQEAQEQLLLCKQKEVEQQTGLSVFLPLVTPDSSALLPSAKADLGRIQESSPTK- 917
+Q Q QL Q+E+ Q LV D+++ L L + E + TK
Sbjct: 1230 TTVQNMQHESAQL----QEELHQLQA----QVLVDSDNNSKLQVDYTGLIQSYEQNETKL 1281
Query: 918 NNIA--VSSDHHVISQL---QDKRLSLSQPILSQQNNFKFLQEQLN--IQKDSLQARREA 970
N ++ H I QL +D L I Q ++ L Q ++ + E+
Sbjct: 1282 KNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSES 1341
Query: 971 QEVLYVHKQSELD--RRVCSEQAEPSFPFQVAQHTFTSLPSADTKSGKIQEQHSSKSEKG 1028
E+L Q EL+ R+ E+ Q H + +A ++ + + + + K
Sbjct: 1342 SELL----QQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQ 1397
Query: 1029 LVSCQSD-----------IPISQDGSLSFLQQFLPLHDSLKLLQEQLTKQRDTLQARHEA 1077
L Q I D LS + F + +LL++ +T +
Sbjct: 1398 LKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLK--------- 1448
Query: 1078 QVELLLHRQRDLGDSKSGLVSSSSSPVVVQHSVASQASAKAEPRRIQELYLSEKENVGPS 1137
E +L + D+G K + V ++ A E + L EKE
Sbjct: 1449 --ERILILEMDIGKLK----GENEKIVETYRGKETEYQALQETNMKFSMMLREKEF---E 1499
Query: 1138 CHLIIPTFQDKSLSFPQ-----------------HSLAQQENLTILQEQSQIQRVILGAK 1180
CH + ++K+L+F Q +++ + T++ +Q + Q V+L K
Sbjct: 1500 CH----SMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQ-VMLALK 1554
Query: 1181 EGTQEFVHTESELEKRISSEQTGTSSSLSQVD----ESERFQECISIKSDSTIPLSHPKI 1236
+ E ++E++ R+ ++ ++ L ++ ESE ++ ++ K+
Sbjct: 1555 QKQMENTALQNEVQ-RLRDKEFRSNQELERLRNHLLESEDSYTREALAAEDREAKLRKKV 1613
Query: 1237 PRCQERLLRVSQHMLPLQDNLEEHQAWLDTE--KEAFHFSQKTQENTSSEQTGSSSFIPQ 1294
+E+L+ S M HQA + E +E + K ++ T+ + + S + Q
Sbjct: 1614 TVLEEKLVSSSNAM-----ENASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQ 1668
Query: 1295 LVQLSFTSLASAESGTILEPLFTESESKIFSSHLQ------------IPQLQDRLLRISQ 1342
+L+ A +LE F + E ++S+ L+ L+ +++ + +
Sbjct: 1669 Y------ALSLANLQMVLEH-FQQEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQE 1721
Query: 1343 LIQPQQ---DNLKALQEQLATQREAI--ILARQEAREELL 1377
+ D+ L EQL + E I + + E R+E+L
Sbjct: 1722 CLDEANAALDSASRLTEQLDVKEEQIEELKRQNELRQEML 1761
Score = 43.1 bits (100), Expect = 0.004
Identities = 193/1034 (18%), Positives = 375/1034 (36%), Gaps = 161/1034 (15%)
Query: 809 EPFSAMSKSTVSTSHSIISQMHDRPLLPSENITAQQGNMKALQEQLDLQKKVLQATQEA- 867
E A+ +S + + + ++ I Q + + +Q +++ L+A Q A
Sbjct: 58 EAIHAILRSENERLKKLCTDLEEKHEASEIQIKQQSTSYRNQLQQKEVEISHLKARQIAL 117
Query: 868 QEQLLLCKQKEVEQQTGLSVFLPLVTPDSSALL-----PSA----KADLGRIQESSPTKN 918
Q+QLL K + Q +P T SS PSA D G I S N
Sbjct: 118 QDQLL--KLQSAAQSVPSGAGVPATTASSSFAYGISHHPSAFHDDDMDFGDIISSQQEIN 175
Query: 919 NIA---------VSSDHHVI--SQLQDKRLSLSQPILSQQNNFKFLQEQLNIQKDSLQAR 967
++ V H+ S+ Q S I QN K L++ + + D Q
Sbjct: 176 RLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQNIIKELKQNRSQEIDDHQHE 235
Query: 968 REAQEVLYVHKQSELDRRVCSEQAEPSFPFQVAQHTFTSLPSA--DTKSGKIQEQHSSKS 1025
+ + K +E+ RR E ++ + ++ S +T KI E
Sbjct: 236 MSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIETDLSKIYEM----- 290
Query: 1026 EKGLVSCQSDIPISQDGSLSFLQQFLPLHDSLKLLQEQLTKQRDTLQARHEAQVELLLHR 1085
Q I + Q + ++ L D +K + ++L+ + Q +L + +
Sbjct: 291 -------QKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEK 343
Query: 1086 QRDLGDSKS-GLVSSSSSPVVVQHS--------VASQASAKAEPRRIQELYLSEKENVGP 1136
++ + + ++ L S P V+ S + +Q+++ E R+Q+ LS+ EN
Sbjct: 344 RQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQA-LSDAEN--- 399
Query: 1137 SCHLIIPTFQDKSLSFPQHSLA------QQENLTILQEQSQIQRVILGAKEGTQEFVHTE 1190
+ QD SL+ L ++E + QE+ ++Q +L ++ E
Sbjct: 400 EIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLK--------LNNE 451
Query: 1191 SELEKRISSEQTGTSSSLSQVDESERFQECISIKSDSTIPLSHPKIPRCQERLLRVSQHM 1250
E+ K ++ S L + + +E +S S +I + ++HM
Sbjct: 452 YEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHM 511
Query: 1251 LPLQDNLEEHQAWLDTEKEAFHFSQKTQENTSSEQTGSSSFIPQLVQLSFTSLASAESGT 1310
+ ++D L + Q E K +++ + E+ ++ QL + +
Sbjct: 512 ILIKDQLSKQQ------NEGDSIISKLKQDLNDEKK-------RVHQLEDDKMDITKELD 558
Query: 1311 ILEPLFTESESKIFSSHLQIPQLQDRLLR-ISQLIQPQQDNLKALQEQLATQREAIILAR 1369
+ + +SE + HL +L+D++ + QL + Q+ N+ +E L
Sbjct: 559 VQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENL----------- 607
Query: 1370 QEAREELLLHQSEWEGRISPEQVDTSSLPLVPQHSFASLPLNESERNQEPCSINSDNIVS 1429
E +E + ++ E RI E + SL +F L E E N +
Sbjct: 608 -ELKEHIRQNEEELS-RIRNELMQ--SLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQ 663
Query: 1430 SGHSEIPTLPDGLLGLSHLVLPQQDNLIALEEHLHAQTDFLPSIEKTQ------------ 1477
+ D + LVL +D LEE L S+EK
Sbjct: 664 LNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQL--SLEKNTIVETLKMEKGEI 721
Query: 1478 -------KELVLSKPCKFEEKVS--------SEHFIQSHHGDLQALQQQLDTQ----KKA 1518
K+ +L + K+E+ + + +Q H L L Q+ D + KK
Sbjct: 722 EAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKN 781
Query: 1519 IRSIQEVQEELL------LQRLSELEKRVSSEQVCSSSFVSQVPVADSERTQKSFPTKSN 1572
I + +E L+ +L + ++ +++ + E + S + N
Sbjct: 782 IEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKN 841
Query: 1573 DTLPSSHREIPRLQDRLLSLSKPILPQQDNMTAQLDAQREVMYSYEKPQEELSLNKQRKL 1632
+ L + E +DR L K + +++ +L+ RE + +L+ +L
Sbjct: 842 EILRQTIEE----KDRSLGSMKE---ENNHLQEELERLREEQSRTAPVADPKTLDSVTEL 894
Query: 1633 NKSESAEHTIPSLFLPKETEHSFIPLPFAEAKPKSTCELYSSQNEHAAPPSNPVIPGFQD 1692
S +TI L +E +H E + +S +L S E D
Sbjct: 895 ASEVSQLNTIKE-HLEEEIKHH---QKIIEDQNQSKMQLLQSLQEQKKE---------MD 941
Query: 1693 RLLSFSQSVLTQQDNLGLQKQLDLQREVLHYSQKAQEKLLVQRQTALQQQIQKHEETLKD 1752
+ + L L+K ++ K+ +K + Q +T L ++ Q + D
Sbjct: 942 EFRYQHEQMNATHTQLFLEKDEEI---------KSLQKTIEQIKTQLHEERQDIQTDNSD 992
Query: 1753 FFKDSQISKPTVEN 1766
F+++++ +EN
Sbjct: 993 IFQETKVQSLNIEN 1006
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 70.1 bits (170), Expect = 3e-11
Identities = 268/1379 (19%), Positives = 502/1379 (36%), Gaps = 243/1379 (17%)
Query: 36 QVREQERDIALQIRED--IKQRRNQQFTRLAEELRAEWEESQTQKIQNLEKLYLASLRSM 93
Q+ + DI + E+ +++ Q+ TRL EEL E Q K + L++ + + +
Sbjct: 167 QLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVL 226
Query: 94 GEGHRQAKENEPDLDALAQRAAERKRKADLRHKEALKVQKN--QKEILLKQKTWHIKARK 151
KE + ER+R+++ E K+Q E + Q +
Sbjct: 227 ------KKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGP 280
Query: 152 EALLVEKERSAKITS----LPPPPPTLFENIEVKRISAVKTNSSTYHHLHTFVNRETDTK 207
+ + V + K+ S L TL EN+ K K H+ + +
Sbjct: 281 QEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEK--HNEESVSKKNIQAT 338
Query: 208 RPDARLAAEEEAKRLEELQKQAAQERMERFEKAHVRGFQAMKKIHLAQNQEKLMKELKQL 267
L ++ RL + + +E EK + + + L E KQL
Sbjct: 339 LHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQL 398
Query: 268 QQEDLARRRQTVAQMPPQLVELPYKRSEMKEDWQRELEFAFEDMYNADRKVKGNLILHLE 327
QQ+ + Q Q+ ++ +L K E + + A ++K L
Sbjct: 399 QQQR-EEKEQHGLQLQSEINQLHSKLLETERQ-----------LGEAHGRLKEQR--QLS 444
Query: 328 PEPLPTVTNQIQDEELDLSMEQENLGAAEDLPVTEAEICSSETDVPLVMKTQQIPSKVLF 387
E L Q+ D +L LS +E L VT + + D K Q + L
Sbjct: 445 SEKLMDKEQQVADLQLKLSRLEEQLKEK----VTNSTELQHQLDKT---KQQHQEQQALQ 497
Query: 388 KKLLNKIR-SQKSLWTIKSMSEDESEMITTVSEIESKAPTVESGTIASKERTLSSGQEQV 446
+ K+R +Q L + D+ + I + + K+ E+ ++ KER + Q
Sbjct: 498 QSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSK--ENISLLEKEREDLYAKIQA 555
Query: 447 VESDTLTIESGPLASEDKPLSCGTNSGKEQEINETLPITTVAQSSVLLHPQEAAARIRMS 506
E +T + + QE N TL + L + E+
Sbjct: 556 GEGETAVLN------------------QLQEKNHTLQEQVTQLTEKLKNQSES------- 590
Query: 507 ARQKQIME-IEEQKQKQLELLEQIEQQKLRLETDC--FRAQLEEEKRKKTQPTGVGIAPA 563
KQ E + +Q Q+Q L + + L LET +QL E K K +Q + I
Sbjct: 591 --HKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQ-LDIQIKAK 647
Query: 564 SCPVISDEDSHRQMIRNYQHQLLQQNRLHRQSVETARKQLLEYQTMLKGRCPSVSAPSLI 623
+ ++S E + + Q+ L +TA+ L + Q L +
Sbjct: 648 TELLLSAEAAKTAQRADLQNHL-----------DTAQNALQDKQQELNKITTQL------ 690
Query: 624 TDSVISVPSWKSERPTAISEHWDQGQRLKLSPNKYQPIQPIQTSKLEQDHFQV------A 677
D V + K E + + H + + LS + Q KLE D +V A
Sbjct: 691 -DQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQA 749
Query: 678 RQNHFPQRQVETTETLRASDILTNQALESQEHLRQFSQTETQQRDYKLVPKDSETLSRAL 737
Q+ QRQ+ T LRA+++ ++ LE ++ + ++ + Q++ L E++ + L
Sbjct: 750 LQDLQQQRQLNTDLELRATEL--SKQLEMEKEIVSSTRLDLQKKSEAL-----ESIKQKL 802
Query: 738 S---HDRQLISQDARKISETFGATTFQSLESQQLFSENSENISYHLTEPSSFVPLVPQHS 794
+ ++Q++ QD +S+ E++ E + I +TE
Sbjct: 803 TKQEEEKQILKQDFETLSQ----------ETKIQHEELNNRIQTTVTELQK--------- 843
Query: 795 FSSLPVKVESGKIQEPFSAMSKSTVSTSHSIISQMHDRPLLPSENITAQQGNMKALQEQL 854
VK+E + S + S S L + ++ N K L
Sbjct: 844 -----VKMEKEALMTELSTVKDKLSKVSDS----------LKNSKSEFEKENQKGKAAIL 888
Query: 855 DLQKKVLQATQEAQEQLLLCKQKEVEQQTGLSVFLPLVTPDSSALLPSAKADLGRIQESS 914
DL+K +E + QL + + +++Q L L S L K +L +QE
Sbjct: 889 DLEK----TCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQL----KLELNSMQEQL 940
Query: 915 PTKNNIAVSSDHHVISQLQDKRLSLSQPILSQQNNFKFLQEQLNIQKDSLQARREAQEVL 974
N ++ QLQ L Q ++ + LQ +L I
Sbjct: 941 IQAQNTLKQNEKEE-QQLQGNINELKQSSEQKKKQIEALQGELKIA-------------- 985
Query: 975 YVHKQSELDRRVCSEQAEPSFPFQVAQHTFTSLPSADTKSGKIQEQHSSKSEKGLVSCQS 1034
V +++EL+ ++ + Q AQ +A+ + + + + KS++ QS
Sbjct: 986 -VLQKTELENKLQQQLT------QAAQEL-----AAEKEKISVLQNNYEKSQETFKQLQS 1033
Query: 1035 DIPISQDGSLSFLQQFLPLHDSLKLLQEQLTKQRDTLQARHEAQVELLLHRQRDLGDSKS 1094
D + L+ Q + + L L QE L R+ + +++ EL
Sbjct: 1034 DFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQEL------------- 1080
Query: 1095 GLVSSSSSPVVVQHSVASQASAKAEPRRIQELY----LSEKENVGPSCHLI----IPTFQ 1146
++ + Q S + + + +Q++ L EKE V L I Q
Sbjct: 1081 ----KTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQ 1136
Query: 1147 DKSLS-----FPQHSLAQQENLTILQEQSQI---QRVILGAKEGTQEFVHTESELEKRIS 1198
+K ++ H L + +T L++ Q+ Q++ L K + + + + ++I
Sbjct: 1137 EKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQIL 1196
Query: 1199 SEQTGTSSSLSQVDESERFQECI--SIKSDSTIPLSHPKIPRCQERLLRVSQHMLPLQDN 1256
+Q + +E E +E I K S I + + +E +++ + L +N
Sbjct: 1197 KDQV-------KKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNEN 1249
Query: 1257 LEEHQAWLDTEKEAFHFSQK---TQENTSSEQTGSSSFIPQLVQLSFTSLASAESGTILE 1313
L T K+ + SQ+ E + + G + + VQ + E +LE
Sbjct: 1250 -------LGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNN-----QDERRALLE 1297
Query: 1314 PLFTESESKIFSSHLQIPQLQDRLLRISQLIQPQQDNLKALQEQLATQREAIILARQEA 1372
+ +I +LQ ++L +Q + DN A ++L + +++ + +A
Sbjct: 1298 --------RCLKGEGEIEKLQTKVLE----LQRKLDNTTAAVQELGRENQSLQIKHTQA 1344
Score = 66.6 bits (161), Expect = 3e-10
Identities = 185/984 (18%), Positives = 390/984 (39%), Gaps = 150/984 (15%)
Query: 852 EQLDLQKKVLQATQEAQEQLLLCKQKEVEQQTGLSVFLPLVTPDSSALLPSAKADLGR-- 909
E + + KK L Q + + L +++E E+ L S A + +++L +
Sbjct: 221 EDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGP 280
Query: 910 ------IQESSPTKNNIAVSSDHHVISQLQDKRLSLSQPILSQQNNFKFLQEQLN---IQ 960
+QE K+++ ++L K +L++ +L ++ ++ L+E+ N +
Sbjct: 281 QEVAVYVQELQKLKSSV---------NELTQKNQTLTENLLKKEQDYTKLEEKHNEESVS 331
Query: 961 KDSLQARREAQEVLYVHKQSELDRRVCSEQ---AEPSFPFQVAQHTFTSLPSADTKSG-- 1015
K ++QA +++ QS L S E S + Q L +TK
Sbjct: 332 KKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHL 391
Query: 1016 -----KIQEQHSSKSEKGLVSCQSDIPISQDGSLSFLQQFLPLHDSLKLLQEQLTKQRDT 1070
++Q+Q K + GL QS+I L +Q H LK Q QL+ ++
Sbjct: 392 KAEFKQLQQQREEKEQHGL-QLQSEINQLHSKLLETERQLGEAHGRLKE-QRQLSSEKLM 449
Query: 1071 LQARHEAQVELLLHRQRDLGDSKSGLVSSSSSPVVVQHSVASQASAKAEPRRIQELYLSE 1130
+ + A ++L L R + K V++S+ +QH + E + +Q+ ++
Sbjct: 450 DKEQQVADLQLKLSRLEEQLKEK---VTNSTE---LQHQLDKTKQQHQEQQALQQSTTAK 503
Query: 1131 KENVGPSCHLIIPTFQDKSLSFPQ-HSLAQQ--ENLTILQEQSQIQRVILGAKEGTQEFV 1187
++ DK +L Q+ EN+++L+++ + + A EG +
Sbjct: 504 LREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVL 563
Query: 1188 HTESELEKRISSEQTGTSSSLSQVDESER-FQECISIKSDSTIPLSHPKIPRCQERLLRV 1246
+ E + + T + L ES + QE + H ++ + L
Sbjct: 564 NQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENL-----------HDQVQEQKAHLRAA 612
Query: 1247 SQHMLPLQDNLEEHQAWLDTEKEAFHFSQKTQENTSSEQTGSSSFIPQLVQLSFTSLASA 1306
+L L+ ++ E + L+ KE Q +E + LS + +A
Sbjct: 613 QDRVLSLETSVNELNSQLNESKEKVS-QLDIQIKAKTE-----------LLLSAEAAKTA 660
Query: 1307 ESGTILEPLFTESESKIFSSHLQIPQLQDRLLRISQLIQPQQDNLKALQEQLATQREAII 1366
+ + L T +++ + ++ ++ +L +++ +Q +Q++ L+ L +E +
Sbjct: 661 QRADLQNHLDT-AQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYL 719
Query: 1367 LARQEAREELLLHQSEWEGRISPEQVDTSSLPLVPQHSFASLPLNESERNQEPCSINSDN 1426
Q+ E EG+I + D+ + + + L Q+ +N+D
Sbjct: 720 SLEQKTEE--------LEGQIKKLEADSLEVKASKEQALQDL--------QQQRQLNTDL 763
Query: 1427 IVSSGHSEIPTLPDGLLGLSHLVLPQQDNLIALEEHLHAQTDFLPSIE----KTQKELVL 1482
+ + LS + +++ + + L +++ L SI+ K ++E +
Sbjct: 764 ELRATE------------LSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQI 811
Query: 1483 SKPCKFEEKVSSEHFIQSHHGDLQALQQQLDTQKKAIRSIQEVQEELLLQRLSELEKRVS 1542
K + E +S E IQ H +L Q T+ + ++ +++E L+ LS ++ ++S
Sbjct: 812 LK--QDFETLSQETKIQ--HEELNNRIQTTVTELQKVK----MEKEALMTELSTVKDKLS 863
Query: 1543 ----SEQVCSSSFVSQ-----VPVADSERTQKSFP----TKSNDTLPSSHREIPRLQDRL 1589
S + S F + + D E+T K + +TL +E+ + ++
Sbjct: 864 KVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTL-KEQKELKKSLEKE 922
Query: 1590 LSLSKPILPQQDNMTAQLDAQREVMYSYEKPQEELSLNKQRKLNKSESAEHTIPSLFLPK 1649
S + + ++M QL + + EK +++L N SE + I +L
Sbjct: 923 KEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEAL---- 978
Query: 1650 ETEHSFIPLPFAEAKPKSTCELYSSQNEHAAPPSNPVI---------PGFQDRLLSF--- 1697
+ E L E + K +L + E AA + F+ F
Sbjct: 979 QGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGR 1038
Query: 1698 -SQSVLTQQDNLGLQKQLDLQREVLHYSQKA---QEKLLVQRQTAL----------QQQI 1743
S+ + T+QD ++++L L +E L ++ Q KL+ + +TA +QQ+
Sbjct: 1039 ESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQL 1098
Query: 1744 QKHEETLKDFFKDSQISKPTVEND 1767
Q+ + L+D K+ + + + N+
Sbjct: 1099 QERCKALQDIQKEKSLKEKELVNE 1122
Score = 61.2 bits (147), Expect = 1e-08
Identities = 111/570 (19%), Positives = 243/570 (42%), Gaps = 58/570 (10%)
Query: 1 MKRKVVNTHKLRLSPNEEAFILKEDYERRRKLRLLQVREQERDIALQIREDIKQRRNQQF 60
M++++V++ +L L EA E +++ L +E+E+ I Q E + Q Q
Sbjct: 776 MEKEIVSSTRLDLQKKSEAL---ESIKQK-----LTKQEEEKQILKQDFETLSQETKIQH 827
Query: 61 TRLAEELRAEWEESQTQKIQNLEKLYLASLRSMGEGHRQAKENEPDLDALAQRAAERKRK 120
L R + ++ QK++ ++ + L ++ + + ++ + + ++ ++ +
Sbjct: 828 EELNN--RIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKA 885
Query: 121 ADLRHKEALKVQKNQKEILLKQKTWHIKARKEALLVEKERSAKITSLPPPPPTLFENIEV 180
A L ++ K K+Q ++ ++ K K++L EKE S + L ++ E + +
Sbjct: 886 AILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQ---LKLELNSMQEQL-I 941
Query: 181 KRISAVKTNSSTYHHLHTFVNRETDTKRPDARLAAEEEAKRLEELQ---KQAAQERMERF 237
+ + +K N L +N + + ++E++ K++E LQ K A ++ E
Sbjct: 942 QAQNTLKQNEKEEQQLQGNIN--------ELKQSSEQKKKQIEALQGELKIAVLQKTELE 993
Query: 238 EKAHVRGFQAMKKIH--------LAQNQEKLMKELKQLQQEDLARRRQTVAQMPPQLVEL 289
K + QA +++ L N EK + KQLQ + R + +A
Sbjct: 994 NKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLAT-------- 1045
Query: 290 PYKRSEMKEDWQRELEFAFEDMYNADRKVKGNLILHLEPEPLPTVTNQIQDEELDLSMEQ 349
R ++K + +L A ED+ + +R GN ++ T + QD Q
Sbjct: 1046 ---RQDLKSV-EEKLSLAQEDLIS-NRNQIGNQNKLIQELKTAKATLE-QDSAKKEQQLQ 1099
Query: 350 ENLGAAEDLP----VTEAEICSSETDVPLVMKTQQIPSKVLFKKLLNKIRSQK--SLWTI 403
E A +D+ + E E+ + ++ + + + + K + KL +++S K S+ I
Sbjct: 1100 ERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEI-TKLNEELKSHKLESIKEI 1158
Query: 404 KSMSEDESEMITTVSEIESKAPTVESGTIASKERTLSSGQEQVVESDTLTIE----SGPL 459
++ + + +I E++ KA ++++ K + E + L E L
Sbjct: 1159 TNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKL 1218
Query: 460 ASEDKPLSCGTNSGKEQEINETLPITTVAQSSVLLHPQEAAARIRMSARQKQIMEIEEQK 519
SE K G +E E T+ IT + ++ + + +++ R+S +KQ ++ +
Sbjct: 1219 HSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEI 1278
Query: 520 QKQLELLEQIEQQKLRLETDCFRAQLEEEK 549
++ + ++ L C + + E EK
Sbjct: 1279 AVLEATVQNNQDERRALLERCLKGEGEIEK 1308
Score = 41.6 bits (96), Expect = 0.010
Identities = 99/558 (17%), Positives = 212/558 (37%), Gaps = 48/558 (8%)
Query: 2054 EANLIPEKTDLQELEHIFPNL--HHQLFKPLEPHPDFDLSSSSSGISPDNRDFYQRSDSS 2111
E L + T+ EL+H HQ + L+ L + + + R +
Sbjct: 466 EEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKI 525
Query: 2112 SESHCATGLSKSTVYFTALRRTSMHSSLNTSPNQQPDTNLAHVGAHSFA------TENII 2165
SK + R +++ + + N H+ TE +
Sbjct: 526 QNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLK 585
Query: 2166 GGSEQCFEQLQPEYSSQEESQHADLPSIFSIEARDSSQGMKNQNYPSEEHTEILQNKKKI 2225
SE +Q Q Q + Q A L + A+D ++ +E ++++ ++K+K+
Sbjct: 586 NQSES-HKQAQENLHDQVQEQKAHLRA-----AQDRVLSLETS--VNELNSQLNESKEKV 637
Query: 2226 VHFQLSIGNLSSVYSSSDEANVFDQLNVQHSTPCGSNSSECSTK--HQLESRKESMGFEE 2283
+ I + + S++ A + ++Q+ N+ + + +++ ++ + + +
Sbjct: 638 SQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKL 697
Query: 2284 LSKRGVVTMLQSQGLIEDNKNETCRVLDINPQVEETDSRLCVRTVEMGTSIQAPYSLTTQ 2343
K+ + L+S +++ K + + ++E +L ++E+ S + Q
Sbjct: 698 QDKQEHCSQLESH--LKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQ-DLQ 754
Query: 2344 NEKYFENSAETDIPKITKKLSQLGESELFASSGSFSLQSSIPVWETETGHGIMEEPELTL 2403
++ E +++K+L E E+ SS LQ E+ +E E
Sbjct: 755 QQRQLNTDLELRATELSKQLEM--EKEI-VSSTRLDLQKKSEALESIKQKLTKQEEE--- 808
Query: 2404 ISTTDTSIAEMDFANLTLEEKSENEA---KCFFQVSEFLPLVSATEASDYPAVSELSIEK 2460
I + DF L+ E K ++E + V+E + EA ++ELS K
Sbjct: 809 -----KQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEA----LMTELSTVK 859
Query: 2461 PRTASTETPRRLTPVPGSLQE-----AFIKRKKSFMERSHQRQKEIRNKIHVSENSQIKT 2515
+ + + + + A + +K+ E HQ Q ++ N + E ++K
Sbjct: 860 DKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTL--KEQKELKK 917
Query: 2516 VKEKPSISSSVSRLKGVNKVRASFPEDRKTTQALRHQRGLRLYNQLAEVKQQKEEKTKQE 2575
EK +S +L+ +N ++ + + T + + +L + E+KQ E+K KQ
Sbjct: 918 SLEKEKEASHQLKLE-LNSMQEQLIQAQNTLKQ-NEKEEQQLQGNINELKQSSEQKKKQI 975
Query: 2576 AYAQNRARAKEFHKKTLE 2593
Q + K LE
Sbjct: 976 EALQGELKIAVLQKTELE 993
Score = 39.7 bits (91), Expect = 0.039
Identities = 203/1110 (18%), Positives = 395/1110 (35%), Gaps = 204/1110 (18%)
Query: 1159 QQENLTILQEQSQIQRVILGAKEGTQEFVHTESELEKRISSEQTGTSSSLSQVDESERFQ 1218
+++++T+L+++ Q + L ++ E + ELEK +Q D S Q
Sbjct: 81 KRDDVTLLRQEVQDLQASLKEEKWYSE--ELKKELEKYQGLQQQEAKPDGLVTDSSAELQ 138
Query: 1219 ECISIKSDSTIPLSHPKIPRCQERLLRVSQHMLPLQDNLEEHQAWLDTEKEAFHFSQKTQ 1278
++ Q + Q ++D E+ A L TE K
Sbjct: 139 SL------------EQQLEEAQTENFNIKQ----MKDLFEQKAAQLATE--IADIKSKYD 180
Query: 1279 ENTSSEQTGSSSFIPQLVQLSFTSLASAESGTILEPLFTESESKIFSSHLQIPQLQDRLL 1338
E S + +L+ + T+++ L TE LQ P ++D +
Sbjct: 181 EERSLREAAEQKVTRLTEELN-------KEATVIQDLKTEL--------LQRPGIEDVAV 225
Query: 1339 RISQLIQPQ-----------------QDNLKALQEQLATQREAIILARQEAR-------- 1373
+L+Q Q +D K LQ Q A+ I R E
Sbjct: 226 LKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAV 285
Query: 1374 --EELLLHQSEWEGRISPEQVDTSSLPLVPQHSFASLPLNESERNQEPCSINSDNIVSSG 1431
+EL +S Q T +L L + + L E + N+E S++ NI ++
Sbjct: 286 YVQELQKLKSSVNELTQKNQTLTENL-LKKEQDYTKL---EEKHNEE--SVSKKNIQATL 339
Query: 1432 HS---EIPTLPDGL------LGLSHLVLPQQDNLIA-LEEHLHAQTDFLPSIEKTQKELV 1481
H + L L L H+ L ++ L+E L ++ K+L
Sbjct: 340 HQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQ 399
Query: 1482 LSKPCKFEEKVSSEHFIQSHHGDLQALQQQLDTQKKAIRSIQEVQEELLLQR-------- 1533
+ K + + + I H L ++QL ++ +++ E L+ +
Sbjct: 400 QQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQ 459
Query: 1534 --LSELEKRVSSEQVCSSSFVSQVPVADSE-RTQKSFPTKSNDTLPSSHREIPRLQDRLL 1590
LS LE+++ + S+ Q+ + + Q++ + L + ++ ++ ++
Sbjct: 460 LKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIG 519
Query: 1591 SLSKPILPQQDNMTAQLDAQREVMYSYEKPQEELSLNKQRKLNKSESAEHTIPSLFLPKE 1650
+ I N+ A L +E + EK +E+L K+ E + L
Sbjct: 520 DKDQKI----QNLEALLQKSKENISLLEKEREDL----YAKIQAGEGETAVLNQLQEKNH 571
Query: 1651 TEHSFIPLPFAEAKPKSTCELYSSQNEHAAPPSNPV-IPGFQDRLLSFSQSV--LTQQDN 1707
T + + K +S + +N H + QDR+LS SV L Q N
Sbjct: 572 TLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLN 631
Query: 1708 LGLQK--QLDLQREVLHYSQKAQEKLLVQRQ---TALQQQIQKHEETLKDFFKDSQ--IS 1760
+K QLD+Q KA+ +LL+ + TA + +Q H +T ++ +D Q ++
Sbjct: 632 ESKEKVSQLDIQI-------KAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELN 684
Query: 1761 KPTVENDLKTQKMGQLRDWFPNTQDLAGNDQENIRHADRNNSDDNHLASEDTSAKQSGEH 1820
K T + D T K+ Q+ H + S + S +Q E
Sbjct: 685 KITTQLDQVTAKL-----------------QDKQEHCSQLESHLKEYKEKYLSLEQKTEE 727
Query: 1821 LEKDLGRRSSKPPVAKVKCGLDLNQHELSAIQEVESPAIGRTSILGKPGIYEDRDPLRVS 1880
LE I+++E+ D L V
Sbjct: 728 LE--------------------------GQIKKLEA------------------DSLEVK 743
Query: 1881 ISREQSFFGSPLAHDPFSCLQLVGQENVCGDDYDEAVKLKESVVENHAV-LSYAVEEEHA 1939
S+EQ+ D QL + + + +++++ +V + + L E +
Sbjct: 744 ASKEQAL------QDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALES 797
Query: 1940 YLGPTVKPDDKAKTLS--YEPLSSATVSTGSLLSYENTDLSLTDPESFSEHMDDSKQEST 1997
K +++ + L +E LS T L+ ++T+ + + E +
Sbjct: 798 IKQKLTKQEEEKQILKQDFETLSQETKIQHEELN-NRIQTTVTELQKVKMEKEALMTELS 856
Query: 1998 TSKEEETNIISSIVPSTQDIYQRQNSSDVHKSLLPAVD-ETTCGHTHFQQMIDKYINEAN 2056
T K++ + + S+ S + ++++N K +D E TC Q + N
Sbjct: 857 TVKDKLSKVSDSLKNSKSE-FEKENQ----KGKAAILDLEKTCKELKHQLQVQM----EN 907
Query: 2057 LIPEKTDLQELEHIFPNLHHQLFKPLEPHPDFDLSSSSSGISPDNRDFYQRSDSSSESHC 2116
+ E+ +L++ HQL L + L + + + + ++ Q + +E
Sbjct: 908 TLKEQKELKKSLEKEKEASHQLKLELNSMQE-QLIQAQNTLKQNEKEEQQLQGNINELKQ 966
Query: 2117 ATGLSKSTVY-------FTALRRTSMHSSLNTSPNQQPDTNLAHVGAHSFATENIIGGSE 2169
++ K + L++T + + L Q LA +N S+
Sbjct: 967 SSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQ-ELAAEKEKISVLQNNYEKSQ 1025
Query: 2170 QCFEQLQPEYSSQEESQHADLPSIFSIEAR 2199
+ F+QLQ ++ +E A + S+E +
Sbjct: 1026 ETFKQLQSDFYGRESELLATRQDLKSVEEK 1055
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 69.7 bits (169), Expect = 4e-11
Identities = 113/558 (20%), Positives = 241/558 (43%), Gaps = 72/558 (12%)
Query: 10 KLRLSPNEEAFILKEDYERRRKL---RLLQVREQERDIALQIREDIKQRRNQQFTRLAEE 66
KL+L +E++ I E +RKL +LL ++Q LQ D ++ ++ +
Sbjct: 229 KLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQ-----LQAEAD---HLGKELQSVSAK 280
Query: 67 LRAEWEESQ--TQKIQNLEKLYLASLRSMGEGHRQAKENEPDLDALAQRAAERKRKADLR 124
L+A+ EE++ + Q E+ + E + +E E + ++ E++ K +R
Sbjct: 281 LQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEK--MR 338
Query: 125 HKEALKVQKNQKEILLKQKTWHIKA---RKEALLVEKERSAKITSLPPPPPTLFENIEVK 181
+E + +K +K ++ W + R+E ++ EKE + E + +
Sbjct: 339 RQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQ----------EEMMWE 388
Query: 182 RISAVKTNSSTYHHLHTFVNRETDTKRPDARLAAEEEAKRLEEL----QKQAAQERMERF 237
+ ++ H RE + KR + E+E ++ +E Q++ +E+ E+
Sbjct: 389 KEEKIRELEEKMHEQEKI--REQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKI 446
Query: 238 EKAHVRGFQAMKKIHLAQNQEKLMKELKQLQQEDLARRRQTVAQMPPQLVELPYKRSEMK 297
+ + ++ +KIH QEK+ +E K+ +QE++ R+ + + E +
Sbjct: 447 REQEKKMWRQEEKIH---EQEKIREEEKRQEQEEMWRQEEKI--------------HEQE 489
Query: 298 EDWQRELEFAFEDMYNADRKV-KGNLILHLEPEPLPTVTNQIQDEELDLSMEQENLGAAE 356
E W+++ E M+ + K+ K + + E + +I+++E + ++E + E
Sbjct: 490 EIWRQK-----EKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQE 544
Query: 357 DLPVTEAEICSSETDVPLVMKTQQIPSKVLFKKLLNKIRSQKS-LWT----IKSMSEDES 411
++ E E + + K Q+ K+ ++ KIR Q+ +W I+ E
Sbjct: 545 EM-WREEEKMHEQEKIWEEEKRQEQEDKMWRQE--EKIREQEEKVWRQEEKIREQEEKRQ 601
Query: 412 EMITTVSEIESKAPTVESGTIASKERTLSSGQEQVVESDTLTIESGPLASEDKPLSCGTN 471
E + + E K E I +E + +E++ E + +T E E + C
Sbjct: 602 EQEEKMWKQEEKIREQEE-KIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQE 660
Query: 472 SGKEQEINETLPITTVAQSSVLLHPQEAAARIRMSARQKQIMEIEEQKQKQLELLEQIEQ 531
K QE ET+ + + QE R + ++Q ++EQ++K E E++ +
Sbjct: 661 E-KMQEQEETM-----WRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCE 714
Query: 532 QKLRLETDCFRAQLEEEK 549
Q+ +++ + + +EEK
Sbjct: 715 QEEKMQEQEEKMRRQEEK 732
Score = 52.8 bits (125), Expect = 4e-06
Identities = 109/600 (18%), Positives = 229/600 (38%), Gaps = 66/600 (11%)
Query: 32 LRLLQVREQERDIALQIREDIKQRRNQQFTRLAEELRAEWEESQTQKIQNLEKLYLASLR 91
+R+L ++ E +AL + ++ + L L W+ + LE+ A
Sbjct: 132 IRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDSWKFAG-----ELEQALSAVAT 186
Query: 92 SMGEGHRQAKENEPDLDALA--------------QRAAERKRKADLRHKEALKVQKNQKE 137
+ R +E + DAL+ ++ A+ + K L E ++Q N KE
Sbjct: 187 QKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKE 246
Query: 138 ILLKQKTWHIKARKEALLVEKERSAK-ITSLPPPPPTLFENIEVKRISAVKTNSSTYHHL 196
+ K + + ++ L E + K + S+ E E+ + +
Sbjct: 247 LKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQE 306
Query: 197 HTFVNRETDTKRPDARLAAEEEAKRLEELQKQAAQERM-ERFEKAHVRGFQAMKKIHLAQ 255
E + + ++ +EE R +E + + +E M E+ EK + +K +
Sbjct: 307 EKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMR 366
Query: 256 NQEKLM--KELKQLQQEDLARRRQTVAQMPPQLVELPYKRSEMKEDWQRELEFAFEDMYN 313
QE++M KE K +QE++ ++ + +L E +++ +++E ++ E E +
Sbjct: 367 RQEEMMWEKEEKMRRQEEMMWEKEEKIR---ELEEKMHEQEKIREQEEKRQEE--EKIRE 421
Query: 314 ADRKVKGNLILHLEPEPLPTVTNQIQDEELDLSMEQENLGAAEDLPVTEAEICSSETDVP 373
+++ + + + E + +I+++E + ++E + E + E E
Sbjct: 422 QEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEE---- 477
Query: 374 LVMKTQQIPSKVLFKKLLNKIRSQKSLWTIKSMSEDESEMITTVSEI----ESKAPTVES 429
M Q+ KI Q+ +W K ++ E I E E K E
Sbjct: 478 --MWRQE-----------EKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEE 524
Query: 430 GTIASKERTLSSGQEQVVESDTLTIESGPLASEDKPLSCGTNSGKEQEINETLPITTVAQ 489
I +E + +E++ E + + E + ++K +EQE + +
Sbjct: 525 -KIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWE--EEKRQEQEDKMWRQEEKIRE 581
Query: 490 SSVLLHPQEAAARIRMSARQ-------KQIMEIEEQKQKQLELLEQIEQQKLRLETDCFR 542
+ QE R + RQ KQ +I EQ++K E E+I +Q+ ++
Sbjct: 582 QEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEM 641
Query: 543 AQLEEEKRKKTQPTGVGIAPASCPVISDEDSHRQMIRNYQHQLLQQNRLHRQSVETARKQ 602
Q +EEK + + C + + + ++ +Q + R+ E R+Q
Sbjct: 642 TQEQEEKMGEQE-------EKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQ 694
Score = 38.5 bits (88), Expect = 0.087
Identities = 69/392 (17%), Positives = 149/392 (38%), Gaps = 47/392 (11%)
Query: 1159 QQENLTILQEQSQIQRVILGAKEGTQEFVHTESELEKRISSEQTGTSSSLSQVDESERFQ 1218
Q+E + +E+ + Q ++ KE + + +++I EQ ++ E E+ Q
Sbjct: 368 QEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIR-EQEEKRQEEEKIREQEKRQ 426
Query: 1219 ECISIKSDSTIPLSHPKIPRCQERLLRVSQHMLPLQDNLEEHQAWLDTEKEAFHFSQKTQ 1278
E ++ + KI +E++ + M ++ + E + + EK Q
Sbjct: 427 E-----QEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQ 481
Query: 1279 ENTSSEQTGSSSFIPQLVQLSFTSLASAESGTILEPLFTESESKIFSSHLQIPQLQDRLL 1338
E EQ E ++ + E K+ +I + ++++
Sbjct: 482 EEKIHEQ---------------------------EEIWRQKE-KMHEQEEKIRKQEEKVW 513
Query: 1339 RISQLIQPQQDNLKALQEQLATQREAIILARQEAREELLLHQSE--WEGRISPEQVDT-- 1394
R + I+ Q++ ++ +E++ Q E I + REE +H+ E WE EQ D
Sbjct: 514 RQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMW 573
Query: 1395 SSLPLVPQHSFASLPLNESERNQEPCSINSDNIVSSGHSEIPTLPDGLLGLSHLVLPQQD 1454
+ + E R QE + + +I + + + Q++
Sbjct: 574 RQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEE 633
Query: 1455 NLIALEEHLHAQTDFLPSIEKTQKELVLSKPCKFEEKV-SSEHFIQSHHGDLQALQQQLD 1513
+ EE Q + + E+ K C+ EEK+ E + ++ ++++
Sbjct: 634 KIREQEEMTQEQEEKMGEQEE--------KMCEQEEKMQEQEETMWRQEEKIREQEKKIR 685
Query: 1514 TQKKAIRSIQEVQEELLLQRLSELEKRVSSEQ 1545
Q++ IR +E+ +E + + EK E+
Sbjct: 686 EQEEKIREQEEMMQEQEEKMWEQEEKMCEQEE 717
Score = 37.7 bits (86), Expect = 0.15
Identities = 54/292 (18%), Positives = 120/292 (41%), Gaps = 31/292 (10%)
Query: 12 RLSPNEEAFILKED-YERRRKLRLLQVREQERDIALQIREDIKQRRNQQFTRLAEELRAE 70
++ EE + KE +E+ K+R + + ++ ++ +E+ + + ++ R E++R +
Sbjct: 484 KIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQ 543
Query: 71 ---WEESQTQKIQNLEKLYLASLRSMGEGHRQAKENE-PDLDALAQRAAERKRKADLRHK 126
W E + K+ EK++ R E +E + + + R E+ R+ + + +
Sbjct: 544 EEMWREEE--KMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQ 601
Query: 127 EALKVQKNQKEILLKQKTWHIKARKEALLVEKERSAKITSLPPPPPTLFENIEVKRISAV 186
E + Q+E + +Q+ I+ ++E + +E+ KI E + +
Sbjct: 602 EQEEKMWKQEEKIREQEE-KIQEQEEKI---REQEEKIREQEEMTQEQEEKMGEQEEKMC 657
Query: 187 KTNSSTYHHLHTFVNRETDTKRPDARLAAEEEAKRLEELQKQAAQERMERFEKAHVRGFQ 246
+ T +E + + ++ +EE R +E Q +E+M
Sbjct: 658 EQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKM------------ 705
Query: 247 AMKKIHLAQNQEKLMKELKQLQQEDLARRRQTVAQMPPQLVELPYKRSEMKE 298
QE+ M E ++ QE + R+ +M Q V L + +M+E
Sbjct: 706 --------WEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 749
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 69.3 bits (168), Expect = 5e-11
Identities = 291/1486 (19%), Positives = 589/1486 (39%), Gaps = 217/1486 (14%)
Query: 377 KTQQIPSKVLFKKLLNKIRSQKSLWTIKSMSEDESEMITTVSEIESKAPTVESGTI--AS 434
K + +P + L K ++K + I+ +E+ + E+ SK T +G I A
Sbjct: 21 KLETLPKEDLIKF------AKKQMMLIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKAL 74
Query: 435 KERTLSSGQEQV-VESDTLTIESGPLASEDKPLSCGTNSGKEQEINETLPITTVAQSSVL 493
ER + E+ E L+++ + + + T G + E I V + L
Sbjct: 75 TERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENL 134
Query: 494 LHPQEAAARIRMSARQKQIM-EIEEQKQKQLELLEQIEQQ--------KLRLETDCFRAQ 544
+ + A R + S + + ++EE QLEL EQ++ Q KL+ E + R
Sbjct: 135 KN-ELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPG 193
Query: 545 LEEE-------------KRKKTQPTGVGIAPASCPVISDEDSHRQMIRNYQHQLLQQNRL 591
EE+ ++K+T I A+ +++ I + Q +LLQ +
Sbjct: 194 FEEQILYLQKQLDATTDEKKETVTQLQNIIEAN------SQHYQKNINSLQEELLQLKAI 247
Query: 592 HRQSVETARKQLLEYQTMLKGRCPSVSAPSLITDSVISVPSWKSERPTAISEHWDQGQRL 651
H++ V ++ + + + K ++ + + ++++ SE+ +
Sbjct: 248 HQEEV---KELMCQIEASAKEHEAEINKLNELKENLVKQCE-ASEKNIQKKYECELENLR 303
Query: 652 KLSPNKYQPIQPIQTSKLEQDHFQVARQNHFPQRQVETTETLRASDILTNQALESQEHLR 711
K + N Q Q I + L+++ F QV + D L + LESQ +
Sbjct: 304 KATSNANQDNQ-ICSILLQENTFV---------EQVVNEKVKHLEDTL--KELESQHSIL 351
Query: 712 QFSQTETQQRDYKLVPKDSETLSRALSHDRQLISQDARKISETFGATTFQSLESQQLFSE 771
+ T KL D++ + H+R+ + KI+E A Q ++L SE
Sbjct: 352 KDEVTYMNNLKLKL-EMDAQHIKDEFFHEREDLEF---KINELLLAKEEQGCVIEKLKSE 407
Query: 772 NSENISYHLTEPSSFVPLVPQHSFSSLPVKVESGKIQEPFSAMSKSTVSTSHSIISQMHD 831
+ F V QH+ +K + Q+ S ++++ +S S
Sbjct: 408 LAGL-------NKQFCYTVEQHNREVQSLKEQH---QKEISELNETFLSDSEK------- 450
Query: 832 RPLLPSENITAQ---QGNMKALQEQLDLQKKVLQATQEAQEQLLLCKQKEVEQQTGLSVF 888
E +T QG +K E L +K+ E+ +++ Q E+ + G
Sbjct: 451 ------EKLTLMFEIQG-LKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGK--- 500
Query: 889 LPLVTPDSSALLPSAKADLGRIQESSPTK--NNIAVSSDHHVISQLQDKRLSLSQPILSQ 946
++ + ++ +D+ +Q+ T A+ + + +K LS + +
Sbjct: 501 ---ISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPEL 557
Query: 947 QNNFKFLQEQLNIQKDSLQARREAQEVLYVHKQSELDRRVCSEQAEPSFPFQVAQHTFTS 1006
+N K LQE+ + SL R + EL+ ++ S E +++
Sbjct: 558 ENTIKNLQEKNGVYLLSLSQRDTMLK--------ELEGKINSLTEEKDDFINKLKNSHEE 609
Query: 1007 LPSADTKSGKIQEQHSSKSEKGLVSCQSDIPISQDGSLSFLQQFLPLHDSLKLLQEQLTK 1066
+ + K + E+ ++ + + + Q+ L L E+ K
Sbjct: 610 MDNFHKKC--------EREERLILELGKKVEQTIQYNSELEQKVNELTGGL----EETLK 657
Query: 1067 QRDTLQARHEAQVELLLHRQRDLGDSKSGLVSSSSSPVVVQHSVASQASAKAEPRRIQEL 1126
++D +++ ++E L+ + + L + K L + S + ++S+ K + R E+
Sbjct: 658 EKD----QNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSE---KKQLSRDLEV 710
Query: 1127 YLSEKENVGPSCHLIIPTFQDKSLSFPQHSLAQQENLTILQEQSQIQRVILGA------K 1180
+LS+KE+V H+ T +K L Q + +Q+NL L E Q+Q++ + K
Sbjct: 711 FLSQKEDVILKEHI---TQLEKKL---QLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLK 764
Query: 1181 EGTQEFVHTESELEKRISSEQTGTSSSLSQVDES------ERFQECISIKSDSTIPLSHP 1234
E E +E EK + + SL++++E +R ++ + ++ + L
Sbjct: 765 EMGSEV--SEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKC-LQEE 821
Query: 1235 KIPRCQE--RLLR-VSQHMLPLQDNLEEHQAWLDTEKEAFHFSQKTQENTSSE-QTGSSS 1290
+ +C+E LLR Q + L+ LEE Q+ EKEA +N + + + + +
Sbjct: 822 SVVQCEELKSLLRDYEQEKVLLRKELEEIQS----EKEALQSDLLEMKNANEKTRLENQN 877
Query: 1291 FIPQLVQLSFTSLASA----------ESGTILEPLFTESESK--------IFSSHLQIPQ 1332
+ Q+ ++S T S + L+PL + E + + S + P
Sbjct: 878 LLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPS 937
Query: 1333 LQDRLLRISQLIQPQQDNL----KALQEQLATQREAIILARQE---AREELLLHQSEWEG 1385
+++ L + ++ + +NL K +E++ + + A++E +R+E + E E
Sbjct: 938 VKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELES 997
Query: 1386 -RISPEQVDTSSLPLVPQHSFASLPLNESERNQEPCSINSDNIVSSGHSEIPTLPDGLLG 1444
R +Q+ S L+ L E E+ E + + + H I L L
Sbjct: 998 LRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEH-RIEDLTRQLRN 1056
Query: 1445 LS---HLVLPQQDNLIALEEHLHAQTDFLPS--IEKTQKELVLSKPCKFEEKVSSEHFIQ 1499
+ + ++L+A E L + L +E + + ++ K + EK+ E I+
Sbjct: 1057 STLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELE-AEKLQKEQKIK 1115
Query: 1500 SHH---GDLQALQQQLDTQKKAIRSIQEVQEELLLQRLSELEKRVSSEQVCSSSFVSQVP 1556
H +L+ LQ QL +KK +Q+ +EL EL K+ + + + + +
Sbjct: 1116 EHATTVNELEELQVQLQKEKK---QLQKTMQEL------ELVKKDAQQ-----TTLMNME 1161
Query: 1557 VADSERTQKSFP---TKSNDTLPSSHREIPRLQDRLLSLSKPILPQQDNMTAQLDAQREV 1613
+AD ER K T N+ + +EI + + +L + I Q ++ + ++
Sbjct: 1162 IADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKI 1221
Query: 1614 MYSYEKPQEELSLNKQRKLNKSESAEHTIPSLFLPKETEHSFIPLPFAEAKPKSTCELYS 1673
K ++EL+ +KQ + +H I L E E S + + +
Sbjct: 1222 KQLLVKTKKELADSKQAE------TDHLILQASLKGELEASQQQVEVYKIQLAEITSEKH 1275
Query: 1674 SQNEH---AAPPSNPVIPGFQDRLLSFSQSV-LTQQDNLGLQKQLDLQREVLHYSQKAQE 1729
+EH +A + +Q R+ + + + + + + + + +H K Q+
Sbjct: 1276 KIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQK 1335
Query: 1730 -KLLVQRQTALQQQIQKHEETLKDFFK----DSQISKPTVENDLKT 1770
K + Q +T +Q ++H E L D K DSQ + ++L+T
Sbjct: 1336 NKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQT 1381
Score = 59.7 bits (143), Expect = 4e-08
Identities = 239/1299 (18%), Positives = 485/1299 (37%), Gaps = 204/1299 (15%)
Query: 1 MKRKVVNTHKLRLSPNEEAFILKEDYERRR-----KLRLLQVREQERDIALQIREDIKQR 55
+K +V + L+L +A +K+++ R K+ L + ++E+ ++ +
Sbjct: 351 LKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAG 410
Query: 56 RNQQFTRLAEELRAEWE---ESQTQKIQNLEKLYLAS--------------LRSMGEGHR 98
N+QF E+ E + E ++I L + +L+ L+ E +
Sbjct: 411 LNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQ 470
Query: 99 QAKEN--------EPDLDALAQRAAERKRKADLRHKEALKVQKNQKEILLKQKTWHIKAR 150
Q K+ ++ L E K + E++K Q+ L+QK
Sbjct: 471 QEKQEAILNYESLREIMEILQTELGESAGKIS-QEFESMKQQQASDVHELQQKLRTAFTE 529
Query: 151 KEALLV-------EKERSAKITSLPPPPPTLFENIEVKRISAVKTNSSTYHHLHTFVNRE 203
K+ALL E E+ L P +N++ K + Y L + R+
Sbjct: 530 KDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEK--------NGVY--LLSLSQRD 579
Query: 204 TDTKRPDARLAAEEEAKRLEELQKQAAQERMERFEKAHVR--------GFQAMKKIHLAQ 255
T K + ++ + E K + + + E M+ F K R G + + I
Sbjct: 580 TMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNS 639
Query: 256 NQEKLMKELKQLQQEDLARRRQTVAQMPPQLVELPYKRSEMKEDWQRELEFAFEDMYNAD 315
E+ + EL +E L + Q ++ +V++ SE KE E++ +E+
Sbjct: 640 ELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVL-SEDKEVLSAEVKSLYEE----- 693
Query: 316 RKVKGNLILHLEPEPLPTVTNQIQDEELDLSMEQENLGAAEDLPVTEAEICSSETDVPLV 375
N++ E+ LS + E + ++ + + I E + L+
Sbjct: 694 -------------------NNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLM 734
Query: 376 MKTQQIPSKVLFKKLLNKIRSQKSLWT-IKSMSEDESEMITTVSEIESKAPTVESGTIAS 434
++ Q +K+L + + K+ + L+ +K M + SE + ES +
Sbjct: 735 VEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKIN 794
Query: 435 KERTLSSGQ--EQVVESDTLTIESGPLASEDKPLSCGTNSGKEQEINETLPITTVAQSSV 492
+E+ + Q E+V+E + + E+ + C +E+ L Q V
Sbjct: 795 EEKCNLAFQRDEKVLELE----KEIKCLQEESVVQC-------EELKSLL--RDYEQEKV 841
Query: 493 LLHPQEAAARIRMSARQKQIMEIEEQKQKQLELLEQIEQQKLRLETD-----CFRAQLEE 547
LL + + A Q ++E++ +K ++E Q L ++ + C ++++
Sbjct: 842 LLRKELEEIQSEKEALQSDLLEMKNANEKT-----RLENQNLLIQVEEVSQTCSKSEIHN 896
Query: 548 EKRKKTQPTGVGIAP-----------ASCPVISDEDSHRQMIRNYQHQLLQQNRLHRQSV 596
EK K + P A ++ D + ++N L + + +
Sbjct: 897 EKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKN---DPLSSVKELEEKI 953
Query: 597 ETARKQLLEYQTML-KGRCPSVSAPSLITDSVISVPSWKSERPTAISEHWDQGQRLK--- 652
E K+ E + + K + +V A + S + K E + SE ++
Sbjct: 954 ENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLI 1013
Query: 653 LSPNKYQPIQPIQTSKLEQDHFQVARQNHFPQRQVETTETLRASDILTNQALESQEHLRQ 712
Y+ + + EQ + R N+F R + T LR S + E L
Sbjct: 1014 QGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDL-- 1071
Query: 713 FSQTETQQRDYKLVPKDSETLSRALSH-DRQLIS---QDARKISETFGATTFQSLESQQL 768
++ ET Q + KL+ + RA + D++L + Q +KI E ATT LE Q+
Sbjct: 1072 LARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEH--ATTVNELEELQV 1129
Query: 769 FSENSENISYHLTEPSSFVPLVPQHSFSSLPVKVESGKIQEPFSAMSKSTVSTSHSIISQ 828
+ + L + + LV + + + + +E + ++
Sbjct: 1130 QLQKEKK---QLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELN------------- 1173
Query: 829 MHDRPLLPSENITAQQGNMKALQEQLDLQKKVLQATQEAQEQLLLCKQKEVEQQTGLSVF 888
+ +T + ++ L++++ +QK+ + QE L Q+ E+ T +
Sbjct: 1174 ---------QKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIK-- 1222
Query: 889 LPLVTPDSSALLPSAKADLGRIQESSPTKNNIAVSSDHHVISQLQDKRLSLSQPILSQQN 948
L+ L S +A+ + + K + S Q++ ++ L++ I S+++
Sbjct: 1223 -QLLVKTKKELADSKQAETDHLILQASLKGELEASQQ-----QVEVYKIQLAE-ITSEKH 1275
Query: 949 NFKFLQEQLNIQKDSLQARREAQEVLYVHKQSELDRRVCSEQAEPSFPFQVAQ-HTFTSL 1007
+ E L + Q A + Q E R +EQA + F+ + L
Sbjct: 1276 K---IHEHLKTSAEQHQRTLSAYQQRVTALQEEC-RAAKAEQATVTSEFESYKVRVHNVL 1331
Query: 1008 PSADTKSGKIQEQHSSKSEKGLVSCQSDIPISQDGSLSFLQQFLPLHDSLKLLQ------ 1061
KS E +K E+ + D Q + L DS LQ
Sbjct: 1332 KQQKNKSMSQAETEGAKQEREHLEMLID------------QLKIKLQDSQNNLQINVSEL 1379
Query: 1062 EQLTKQRDTLQARHEAQVELLLHRQRDLGD------SKSGLVSSSSSPVVVQHSVASQA- 1114
+ L + DTL RH ++ + ++ +L + S++ ++ S + V Q + ++
Sbjct: 1380 QTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVL 1439
Query: 1115 --SAKAEPRRIQELYLSEKENVGPS-CHLIIPTFQDKSLSFPQHSLAQQENLTILQEQSQ 1171
S + + R +QE + E + + FQ K+ + ++ Q++L L+E+
Sbjct: 1440 RNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRERRN 1499
Query: 1172 IQRVILGAKEGTQEFVHTESELEKRISSEQTGTSSSLSQ 1210
+L T+E E E + +E ++S+ +Q
Sbjct: 1500 TDLPLLDMHTVTRE----EGEGMETTDTESVSSASTYTQ 1534
Score = 53.9 bits (128), Expect = 2e-06
Identities = 242/1210 (20%), Positives = 471/1210 (38%), Gaps = 175/1210 (14%)
Query: 692 TLRASDILTNQALESQEHLRQFSQTETQQRDYKLVPKDSETLSRALSHDRQLISQDARKI 751
+L+ +I Q +E + E +Q V K+ E L L R S+D +
Sbjct: 94 SLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYV-KEIENLKNELMAVRSKYSEDKANL 152
Query: 752 SETFGATTFQSLE-SQQL-FSENSENISYHLTEPSSFVPLVPQHSFSSLPVKVESGKIQE 809
+ LE S+QL F NSE+ L E + + L ++++ ++
Sbjct: 153 QKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEK 212
Query: 810 PFSAMSKSTVSTSHSIISQMHDRPLLPSENITAQQGNMKALQEQLDLQKKVLQATQEAQE 869
K TV+ +II N Q N+ +LQE+L LQ K + +E +E
Sbjct: 213 ------KETVTQLQNIIEA----------NSQHYQKNINSLQEEL-LQLKAIHQ-EEVKE 254
Query: 870 QLLLCKQKEVEQQTGLSVFLPLVTPDSSALLPSAKADLGRIQES------SPTKNNIAVS 923
+ + E + ++ L L+ +A IQ+ + K +
Sbjct: 255 LMCQIEASAKEHEAEINKLNEL----KENLVKQCEASEKNIQKKYECELENLRKATSNAN 310
Query: 924 SDHHVISQLQDKRLSLSQPILSQ----QNNFKFLQEQLNIQKDS--------LQARREAQ 971
D+ + S L + + Q + + ++ K L+ Q +I KD L+ +AQ
Sbjct: 311 QDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQ 370
Query: 972 EVL--YVHKQSELDRRVCSEQAEPSFPFQVAQHTFTSLPSADTKSGKIQEQHSSKSEKGL 1029
+ + H++ +L+ ++ V + + L + + EQH+ + +
Sbjct: 371 HIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLK 430
Query: 1030 VSCQSDIPISQDGSLSFLQ-QFLPLHDSLKLLQEQ---LTKQRDTLQARHEAQVELLLHR 1085
Q +I + LS + + L L ++ L+EQ L +++ +E+ E++
Sbjct: 431 EQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEIL 490
Query: 1086 QRDLGDSKSGLVSSSSSPVVVQHSVASQASAKAEPRRIQELYLSEKENVGPSCHLIIPTF 1145
Q +LG+S +G +S + Q QAS E ++ +EK+ + + + +
Sbjct: 491 QTELGES-AGKISQEFESMKQQ-----QASDVHELQQKLRTAFTEKDALLETVNRL--QG 542
Query: 1146 QDKSLSFPQHSLAQQEN-LTILQEQSQIQRVILGAKEGTQEFVHTESELEKRISSEQTGT 1204
+++ L Q + + EN + LQE++ + + L ++ + ELE +I+S
Sbjct: 543 ENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLK------ELEGKINSLTEEK 596
Query: 1205 SSSLSQV----DESERFQECISIKSDSTIPLSHPKIPRCQERLLRVSQHMLPLQDNLEEH 1260
++++ +E + F + + + L K+ + + + Q + L LEE
Sbjct: 597 DDFINKLKNSHEEMDNFHKKCEREERLILELGK-KVEQTIQYNSELEQKVNELTGGLEET 655
Query: 1261 QAWLDTEKEAFHFSQKTQENTSSEQTGSSSFIPQLVQLSFT-SLASAESGTILEPLFTES 1319
D + + S ++ S+ + L + + S + LE ++
Sbjct: 656 LKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQK 715
Query: 1320 ESKIFSSHLQIPQLQDRLLRISQLIQPQQDNLKALQEQLATQREAIILARQEAREELLLH 1379
E I H I QL+ +L QL+ +QDNL L E Q+ + +E+
Sbjct: 716 EDVILKEH--ITQLEKKL----QLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSE 769
Query: 1380 QSEWEGRISPEQVDTSSLPLVPQHSFASLPLNESERNQEPCSI--NSDNIVSSGHSEIPT 1437
SE E+ D ++ S A + N+E C++ D V EI
Sbjct: 770 VSE-----DSEEKDVVNVLQAVGESLAKI-------NEEKCNLAFQRDEKVLELEKEIKC 817
Query: 1438 LPDGLL----GLSHLVLPQQDNLIALEEHLHA--------QTDFLP---SIEKTQKE--- 1479
L + + L L+ + + L + L Q+D L + EKT+ E
Sbjct: 818 LQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQN 877
Query: 1480 -LV----LSKPCKFEEKVSSEH--FIQSHHGDLQALQQ--------QLDTQKKAIRSIQE 1524
L+ +S+ C E + + FI+ H L+Q +L K ++
Sbjct: 878 LLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPS 937
Query: 1525 VQEELLLQRLSELEKRVSS-EQVCSSSFVSQVPVADSERTQKSFPTKSNDTLPSSHREIP 1583
V+ + L + ELE+++ + E+ C + K K+ L SS +E
Sbjct: 938 VKNDPL-SSVKELEEKIENLEKECKEK-------EEKINKIKLVAVKAKKELDSSRKETQ 989
Query: 1584 RLQDRLLSLSKPILPQQDNMTAQL-------DAQREVMYSYEKPQEELSLNKQRKLNKSE 1636
+++ L SL ++D ++A + ++ + ++ YEK E+L + K+R +
Sbjct: 990 TVKEELESLRS----EKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKER----AN 1041
Query: 1637 SAEHTIPSLFLPKETEHSFIPLPFAEAKPKSTCELYSSQNEHAAPPSNPVIPGFQDRLLS 1696
+ EH I L ++ +S + CE +S NE I Q
Sbjct: 1042 NFEHRIED--LTRQLRNSTL-----------QCETINSDNEDLLAR----IETLQSNAKL 1084
Query: 1697 FSQSVLTQQDNLGLQKQLDLQREVLHYSQKAQE-KLLVQRQTALQQQIQKHEETLKDFFK 1755
+L Q + + +L+ E L QK +E V LQ Q+QK ++ L+ +
Sbjct: 1085 LEVQILEVQRAKAMVDK-ELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQ 1143
Query: 1756 DSQISKPTVENDLKTQKMGQLRDWFPNTQDLAGNDQENIRHADRNNSDDNHLASEDTSAK 1815
+ ++ K + T ++ D+ ++L N + ++NN ++ L E K
Sbjct: 1144 ELELVKKDAQQ--TTLMNMEIADYERLMKEL------NQKLTNKNNKIED-LEQEIKIQK 1194
Query: 1816 QSGEHLEKDL 1825
Q E L++++
Sbjct: 1195 QKQETLQEEI 1204
Score = 35.0 bits (79), Expect = 0.97
Identities = 36/165 (21%), Positives = 71/165 (43%), Gaps = 20/165 (12%)
Query: 1688 PGFQDRLLSFSQSVLTQQDNLGLQKQLDLQREVLHYSQKAQEKLLVQRQTALQQQIQKHE 1747
PGF++++L + + D ++ + + ++ + + +K + Q L Q H+
Sbjct: 192 PGFEEQILYLQKQLDATTDEK--KETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQ 249
Query: 1748 ETLKDFFKDSQISKPTVENDLKTQKMGQLRDWF--------PNTQDLAGNDQENIRHADR 1799
E +K+ QI E++ + K+ +L++ N Q + EN+R A
Sbjct: 250 EEVKELM--CQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATS 307
Query: 1800 NNSDDNHLAS----EDTSAKQ----SGEHLEKDLGRRSSKPPVAK 1836
N + DN + S E+T +Q +HLE L S+ + K
Sbjct: 308 NANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILK 352
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 67.8 bits (164), Expect = 1e-10
Identities = 241/1192 (20%), Positives = 461/1192 (38%), Gaps = 168/1192 (14%)
Query: 646 DQGQRLKLSPNKYQPIQPIQTSKLEQDHFQVARQNHFPQR--QVETTETLRASDI--LTN 701
D+ L+ +P + P+ TS + ++ PQ+ Q E I LT
Sbjct: 132 DEANGLQTTPAS-RATSPLCTSTASMVSSSPSTPSNIPQKPSQPAAKEPSATPPISNLTK 190
Query: 702 QALESQEHLRQFSQTETQQRDYKLVPKDSETLSRALSHDRQLISQDARKISETFGATTFQ 761
A ES +L + + +R+ K+ DR L+ + G T F
Sbjct: 191 TASESISNLSEAGSIKKGERELKI-------------GDRVLVGGTKAGVVRFLGETDFA 237
Query: 762 S-----LESQQLFSENSENIS---YHLTEPSS--FVPL--VPQHSF-SSLPVKVESGKIQ 808
+E + +N ++ Y +P F P+ V + F S+ P K ++ ++
Sbjct: 238 KGEWCGVELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVTKIGFPSTTPAKAKANAVR 297
Query: 809 EPFSAMSKSTV-STSHSIISQMHDRPLLPSENITAQQGNMKALQEQLDLQKKVLQATQEA 867
+ S S S S S +S M + +++++ L E + + T
Sbjct: 298 RVMATTSASLKRSPSASSLSSMSS----VASSVSSRPSRTGLLTETSSRYARKISGTTAL 353
Query: 868 QEQLLLCKQKEVEQQTGLSVFLPLVTPD-SSALLPSAKADLGRIQESSPTKNNIAVSSDH 926
QE L KQ+ +EQ L D A + A + +G I++ + D
Sbjct: 354 QEALKE-KQQHIEQL--------LAERDLERAEVAKATSHVGEIEQELALARD---GHDQ 401
Query: 927 HVISQLQDKRLSLSQPILSQQNNFKFLQEQLNIQK---DSLQARREAQEVLY--VHKQSE 981
HV+ +L+ K L + + L QL +K + LQ R E + + + Q++
Sbjct: 402 HVL-ELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTK 460
Query: 982 LDRRVCSEQAEPSFPFQVAQHTFTSLPSADTKSGKIQEQHS-SKSEKGLV---------- 1030
L+ E E S F+ + DT+ + E+ + EK L
Sbjct: 461 LEHARIKE-LEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELR 519
Query: 1031 -SCQSDIPISQ-DGSLSFLQQFLPLHDSLKLL----QEQLTKQRDTLQAR---HEAQVEL 1081
+S+ P D SLS LQ+ L + L++ Q ++T ++ AR H+ +++
Sbjct: 520 RRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKA 579
Query: 1082 L------LHRQRDLGDSKSGLVSSSSSPVVVQHSVASQASAKAEPRRIQELYLSEKENVG 1135
L L ++ + SK + +S V+ + + + + ++EL +S + +G
Sbjct: 580 LYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLG 639
Query: 1136 PSCHLIIPTFQDKSLSFPQHSLAQQENLTILQEQSQIQRVILGAKEGTQEFVHTESELEK 1195
F + + L Q + LQ Q +R +E ++L K
Sbjct: 640 TET----AEFAELKTQIEKMRLDYQHEIENLQNQQDSERAA-----HAKEMEALRAKLMK 690
Query: 1196 RISSEQTGTSSSLSQVDESERFQECISIKSDSTIPLSHPKIPRCQERLLRVSQHMLPLQD 1255
I ++ + S++D++E D + + + QE ++V + + LQ
Sbjct: 691 VIKEKENSLEAIRSKLDKAE----------DQHLVEMEDTLNKLQEAEIKVKE-LEVLQA 739
Query: 1256 NLEEHQAWLDTEKEAFHFSQKTQENTSSEQTGSSSFIPQLVQLSFTSLASAESGTILEPL 1315
E +D +++ + + + SS ++ +L L +AE +
Sbjct: 740 KCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLR-QQLEAAEKQIKHLEI 798
Query: 1316 FTESESKIFSS--------HLQIPQLQDRLLRISQLIQPQQDNLKALQEQLATQREAIIL 1367
+ES SS L++ LQ+ L +SQ+ + + L+ L+E+ A E +
Sbjct: 799 EKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVS 858
Query: 1368 ARQEAREEL-LLHQSEWEGRISPEQVDTSSLPLVP-QHSFASLPLNESERNQ-EPCSINS 1424
++ +E + LHQ E EQ + S L + + A + E+++ E I +
Sbjct: 859 VQRSMQETVNKLHQKE-------EQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKA 911
Query: 1425 DNIVSSGHSEIPTLPDGLLGLSHLVLPQQDNLIALEEHLHAQTDFLPSIEKTQKELVLSK 1484
+ + +EI + DN L D L E+ +EL L K
Sbjct: 912 KEKLENDIAEIMKM-------------SGDN----SSQLTKMNDELRLKERDVEELQL-K 953
Query: 1485 PCKFEEKVSSEHFIQSHHGDLQALQQQLDTQKKAIRSIQEVQEELLLQRLSELEKRV-SS 1543
K E S F+Q D+ +Q +Q++A + +E ++E L ++LS+LEK++ +S
Sbjct: 954 LTKANENAS---FLQKSIEDMTVKAEQ--SQQEAAKKHEEEKKE-LERKLSDLEKKMETS 1007
Query: 1544 EQVCSSSFVSQVPVADSERTQKSFPTKSNDTLPSSHREIPRLQDRLLSL---SKPILPQQ 1600
C Q A ER TK + L + + + +D+L + +L +
Sbjct: 1008 HNQC------QELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQEL 1061
Query: 1601 DNMTAQLDAQREVMYSYEKPQ--EELSLNKQRKLNKSESAEHTIPSLFLPKET--EHSFI 1656
+ + Q D + + + Q E+++ K L E + T L +T E++
Sbjct: 1062 EELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENN-- 1119
Query: 1657 PLPFAEAKPKSTCELYSSQNEHAAPPSNPVIPGFQDRLLSFSQSVLTQQDNLGLQKQLDL 1716
L E KS EL + +N+ + Q Q Q++N+ L ++L
Sbjct: 1120 -LKNVEELNKSK-ELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGR 1177
Query: 1717 QREVLHYSQKAQEKLLVQRQTALQQQIQKHEETLKDFFKDSQISKPTVENDL 1768
R+ + QK +E+ ++ L Q+ + ++ F KD+ K +++ +
Sbjct: 1178 SRDEVTSHQKLEEE-----RSVLNNQLLEMKKRESKFIKDADEEKASLQKSI 1224
Score = 62.4 bits (150), Expect = 6e-09
Identities = 189/1010 (18%), Positives = 380/1010 (37%), Gaps = 188/1010 (18%)
Query: 37 VREQERDIALQIRE-DIKQRRNQQFTRLAEELRAEW---EESQTQKIQNLEKLYLASLRS 92
++E+++ I + E D+++ + T E+ E + Q + LE + LR+
Sbjct: 357 LKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAK-MDQLRT 415
Query: 93 MGEGHRQAKENEPDLDALAQRAAERKRKADLRHK-EALKVQKNQKEILLKQKTWHIKARK 151
M E + K ++ L Q E+++ DL+ + E + K E K + IK +
Sbjct: 416 MVEAADREK-----VELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELE 470
Query: 152 EALLVEKERSAKITSLPPPPPTLFENIEVKRISAVKTNSSTYHHLHTFVNRETDTKRPDA 211
++LL EK ++ K+ RE + D
Sbjct: 471 QSLLFEKTKADKL------------------------------------QRELE----DT 490
Query: 212 RLAAEEEAKRLEELQKQAA-----------------------------------QERMER 236
R+A E R+ EL+K A QE++E
Sbjct: 491 RVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEV 550
Query: 237 FEKAHVRGFQAMKKIHLAQNQEKLMKELKQL--QQEDLARRRQTVAQMPPQLVELPYKRS 294
H R ++K+ H +E KE+K L E L++ ++ + +L + S
Sbjct: 551 TRTDHQREITSLKE-HFGAREETHQKEIKALYTATEKLSKENES---LKSKLEHANKENS 606
Query: 295 EMKEDWQRELEFAFEDMYNA--DRKVKGNLILHLEPEPLPTVTNQIQDEELDLSMEQENL 352
++ W+ +LE A A + KV + L E + QI+ LD E ENL
Sbjct: 607 DVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENL 666
Query: 353 GAAEDLPVTEAEICSSETDVPLVMKTQQIPSKVLFKKLLNKIRSQKSLWTIKSMSEDESE 412
+ QQ + K + +R++ +K + E E+
Sbjct: 667 ------------------------QNQQDSERAAHAKEMEALRAK----LMKVIKEKEN- 697
Query: 413 MITTVSEIESKAPTVESGTIASKERTLSSGQEQVVESDTLTIESGPLASEDKPLSCGTNS 472
++ I SK E + E TL+ QE ++ L + + K + T+
Sbjct: 698 ---SLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQ 754
Query: 473 GKEQEINETLPITTVAQSSVLLHPQEAAARIRMSARQKQIMEIEEQK----QKQLELLEQ 528
K E + L + + ++S + R ++ A +KQI +E +K K + +
Sbjct: 755 LKATE-EKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRE 813
Query: 529 IEQQKLRL----ETDCFRAQLEEEKRKKTQPTGVGIAPASCPVISDEDSHRQMIRNYQHQ 584
++ ++L+L E +Q++E K+ Q A AS +S + S ++ + N HQ
Sbjct: 814 LQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETV-NKLHQ 872
Query: 585 LLQQNRLHRQSVETARKQLLEYQTMLKGRCPS----VSAPSLITDSVISVPSWKSERPTA 640
+Q + +E R+ L + + + + + A + + + + + +
Sbjct: 873 KEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQ 932
Query: 641 ISEHWDQGQRLKLSPNKYQPIQPIQTSKLEQDHFQVARQNHFPQRQVETTETLRASDILT 700
+++ D+ L+L + +Q ++ +K ++ F Q+ +E +T
Sbjct: 933 LTKMNDE---LRLKERDVEELQ-LKLTKANEN-------ASFLQKSIED---------MT 972
Query: 701 NQALESQEHLRQFSQTETQQRDYKL--VPKDSETLSRALSHD--RQLISQDARKISETFG 756
+A +SQ+ + + E ++ + KL + K ET SH+ ++L ++ R SET
Sbjct: 973 VKAEQSQQEAAKKHEEEKKELERKLSDLEKKMET-----SHNQCQELKARYERATSETKT 1027
Query: 757 ATTFQSLESQQLFSENSENISYHLTEPSSFVPLVPQHSFSSLPVKV--ESGKIQEPFSAM 814
Q+ + + + E S + + + + K + + M
Sbjct: 1028 KHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQM 1087
Query: 815 SKSTVSTSHSIISQMHDRPLLPSENITAQQGNMKALQEQLDLQKKVLQATQEAQEQLLLC 874
+K T S+ L +E T ++ N+K + E+L+ K++L + E+
Sbjct: 1088 TKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNV-EELNKSKELLTVENQKMEEF--- 1143
Query: 875 KQKEVEQQTGLSVFLPLVTPDSSALLPSAKADLGRIQESSPTKNNIAVSSDHHVISQLQD 934
+KE+E L S L + + + ++ E + S +L++
Sbjct: 1144 -RKEIET-------LKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSH-----QKLEE 1190
Query: 935 KRLSLSQPILSQQNNFKFLQEQLNIQKDSLQARREAQEVLYVHKQSELDR 984
+R L+ +L + + + +K SLQ L K +EL++
Sbjct: 1191 ERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEK 1240
Score = 53.1 bits (126), Expect = 3e-06
Identities = 178/1022 (17%), Positives = 388/1022 (37%), Gaps = 179/1022 (17%)
Query: 313 NADRKVKGNLILHLEPEPLPTVTNQIQDEELDLSMEQENLGAAEDLPVTEAEICSSETDV 372
NA R+V L+ P + + + +S G + A S T +
Sbjct: 294 NAVRRVMATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTAL 353
Query: 373 PLVMKT-QQIPSKVLFKKLLNKIRSQKSLWTIKSMSEDESEMITT-------VSEIESKA 424
+K QQ ++L ++ L + K+ + E E E+ V E+E+K
Sbjct: 354 QEALKEKQQHIEQLLAERDLERAEVAKAT---SHVGEIEQELALARDGHDQHVLELEAKM 410
Query: 425 PTVESGTIASKERTLS-----SGQEQVVESDTLTIESGPLASEDKPLSCGTNSGKEQEIN 479
+ + A+ + +++ VE +E + D + +E+
Sbjct: 411 DQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELE 470
Query: 480 ETLPITTVAQSSVLLHPQEAAARIRMSARQKQIMEIEE----QKQKQLELLEQIEQQKLR 535
++L + ++ R+ + + +IME+E+ + Q+ EL ++E K
Sbjct: 471 QSLLFEKTKADKLQRELEDT--RVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPA 528
Query: 536 LETDCFRAQLEE--EKRKKTQPTGVGIAPASCPVISDEDSHRQMIRNYQHQLLQQNRLHR 593
+ D + L+E ++K + T H++ I + + + H+
Sbjct: 529 GDVDMSLSLLQEISSLQEKLEVT--------------RTDHQREITSLKEHFGAREETHQ 574
Query: 594 QSVE---TARKQLLEYQTMLKGRCPSVSAPSLITDSVISVPSWKSERPTAISEHWDQGQR 650
+ ++ TA ++L + LK + + + VI++ WKS+ TAI+ H +
Sbjct: 575 KEIKALYTATEKLSKENESLKSKLEHANKEN---SDVIAL--WKSKLETAIASHQQAMEE 629
Query: 651 LKLSPNKYQPIQ---------PIQTSKLEQDHFQVARQNHFPQRQ---VETTETLRASDI 698
LK+S +K + I+ +L+ H QN + + E LRA +
Sbjct: 630 LKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLM 689
Query: 699 LTNQALES-------------QEHLRQFSQTETQQRDYKLVPKDSETL------------ 733
+ E+ +HL + T + ++ ++ K+ E L
Sbjct: 690 KVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVID 749
Query: 734 ---SRALSHDRQLISQDARKISETFGATTFQSLESQQLFSENS-ENISYHLTEPSSFVPL 789
S+ + + +L+ DA + + + G + + L Q +E +++ SS
Sbjct: 750 NFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASS 809
Query: 790 VP-------------QHSFSSL-----PVKVESGKIQEPFSAMSKSTVSTSHSI---ISQ 828
+ Q + S + ++ E ++E F+ S+ VS S+ +++
Sbjct: 810 ITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNK 869
Query: 829 MHDRPLLPSENITAQQGNMKALQEQLDLQKKVLQATQEAQEQLLLCKQKEVEQQTGLSVF 888
+H + E +++ L+E L + + E +EQL+ K+K + ++
Sbjct: 870 LHQK----EEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEK---LENDIAEI 922
Query: 889 LPLVTPDSSALLPSAKADLGRIQESSPTKNNIAVSSDHHVISQLQDKRLSLSQPILSQQN 948
+ + +SS L TK N + + +LQ K +
Sbjct: 923 MKMSGDNSSQL----------------TKMNDELRLKERDVEELQLK-------LTKANE 959
Query: 949 NFKFLQEQLNIQKDSLQARREAQEVLYVHKQ--SELDRRVCSEQAEPSFPFQVAQHTFTS 1006
N FLQ+ +I+ +++A + QE H++ EL+R++ + + Q
Sbjct: 960 NASFLQK--SIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKAR 1017
Query: 1007 LPSADTKSGKIQEQHSSKSEKGLVSCQSDIPISQDGSLSFLQQFLPLH---DSLKLLQ-- 1061
A +++ E+ +K L+ + + +++ + LQ+ L D K Q
Sbjct: 1018 YERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTA 1077
Query: 1062 -------EQLTKQR--------DTLQARHEAQVELLLHRQRDLGD----SKSGLVSSSSS 1102
EQ+TK++ DT Q + Q EL ++ +L + +KS + + +
Sbjct: 1078 EDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVEN 1137
Query: 1103 PVVVQHSVASQASAKAEPRRIQELYLSEKENVGPSCHLIIPTFQDKSLSFPQHSLAQQEN 1162
+ + + +A ++ Q+L ++ENV + + L + + +
Sbjct: 1138 QKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLA----------EELGRSRDEVTSHQK 1187
Query: 1163 LTILQEQSQIQRVILGAKEGTQEFVHTESELEKRISSEQTGTSSSLSQVD-ESERFQECI 1221
L +E+S + +L K+ +F+ E + + + TS+ L++ D E E+ + +
Sbjct: 1188 LE--EERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEV 1245
Query: 1222 SI 1223
++
Sbjct: 1246 TV 1247
Score = 44.7 bits (104), Expect = 0.001
Identities = 231/1255 (18%), Positives = 484/1255 (38%), Gaps = 216/1255 (17%)
Query: 404 KSMSEDESEMITTVSEIESKAPTVESGTIASKERTLSSGQEQVVESDTLTIESGPLASED 463
K+ + ++ T S ++P+ S ++S SS + + LT S A +
Sbjct: 290 KAKANAVRRVMATTSASLKRSPSASS--LSSMSSVASSVSSRPSRTGLLTETSSRYARKI 347
Query: 464 KPLSCGTNSGKEQE-------INETLPITTVAQSSVLLHPQEAAARIRMSARQKQIMEIE 516
+ + KE++ L VA+++ + E + + ++E+E
Sbjct: 348 SGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELE 407
Query: 517 EQKQKQLELLEQIEQQKLRLETDCFRAQLEEEKRKKTQPTGVGIAPASCPVISDEDSHRQ 576
+ + ++E +++K+ L QLEEEKRK ED +
Sbjct: 408 AKMDQLRTMVEAADREKVELLN-----QLEEEKRKV------------------EDLQFR 444
Query: 577 MIRNYQHQLLQQNRLHRQS-VETARKQLLEYQTMLKGRCPSVSAPSLITDSVISVPSWKS 635
+ + + + + L Q+ +E AR + LE Q++L + + + D+ ++ S KS
Sbjct: 445 V----EEESITKGDLETQTKLEHARIKELE-QSLLFEKTKADKLQRELEDTRVATVSEKS 499
Query: 636 -----ERPTAISEHWDQGQRLKLSPNKYQPIQPIQTSKLE-----QDHFQVARQNHFPQR 685
E+ A+ R +L NK + S L+ Q+ +V R +H QR
Sbjct: 500 RIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDH--QR 557
Query: 686 QVETTETLRASDILTNQALESQEHLRQFSQTETQQRDYKLVPKDSETLSRALSHDRQLIS 745
++ + + EH ++ ET Q++ K + +E LS+ + +
Sbjct: 558 EITSLK----------------EHFG--AREETHQKEIKALYTATEKLSKENESLKSKLE 599
Query: 746 QDARKISETFGATTFQSLES-----QQLFSENSENISYHL-TEPSSFVPLVPQHSFSSLP 799
++ S+ A LE+ QQ E + S L TE + F L Q L
Sbjct: 600 HANKENSDVI-ALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLD 658
Query: 800 VKVESGKIQEPFSAMSKSTVSTSHSIISQMHDRPLLPSENITAQQGNM-KALQEQLDLQK 858
+ E +Q + + ++ +++ ++ A + + KA + L +
Sbjct: 659 YQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEME 718
Query: 859 KVLQATQEAQ---EQLLLCKQKEVEQQTGLSVFLPLVTPDSSALLPSAKADLGRIQESSP 915
L QEA+ ++L + + K EQ + F + LL DL ++++S
Sbjct: 719 DTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLL-----DLDALRKAS- 772
Query: 916 TKNNIAVSSDHHVISQLQDKRLSLSQPILSQQNNFKFLQEQLNIQKD---SLQARREAQE 972
S+ + + L Q + + + K L+ + N + S+ + +E
Sbjct: 773 --------------SEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRE 818
Query: 973 VLYVHKQSELDRRVCSEQAEPSFPFQVAQHTFTSLPSADTKSGKIQEQHSSKSEKGLVSC 1032
+ + Q L +V+Q T K +I ++ +++ + VS
Sbjct: 819 LKLTNLQENLS--------------EVSQVKETL-----EKELQILKEKFAEASEEAVSV 859
Query: 1033 QSDIPISQDGSLSFLQQFLPLHDSLKLLQEQLTKQRDTLQARHEAQVELLLHRQRDLGDS 1092
Q + + + +QF L L+ L+E L + + E + +L+ +++ D
Sbjct: 860 QRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDI 919
Query: 1093 KSGLVSSSSSPVVVQHSVASQASAKAEPRRIQELYLSEKENVGPSCHLIIPTFQDKSLSF 1152
+ S + +SQ + + R++E + E + + T +++ SF
Sbjct: 920 AEIMKMSGDN--------SSQLTKMNDELRLKERDVEELQ--------LKLTKANENASF 963
Query: 1153 PQHSLAQQENLTILQEQSQIQRVILGAKEGTQEFVHTESELEKRISSEQTGTSSSLSQVD 1212
Q S+ E++T+ EQSQ +E ++ + ELE+++S + +S +Q
Sbjct: 964 LQKSI---EDMTVKAEQSQ--------QEAAKKHEEEKKELERKLSDLEKKMETSHNQCQ 1012
Query: 1213 ESERFQECISIKSDSTIPLSHPKIPRCQERLLRVSQHMLPLQDNL----EEHQAWLDTEK 1268
E + E ++ S H +I L + + +L +D L EE+ L +
Sbjct: 1013 ELKARYE----RATSETKTKHEEI------LQNLQKTLLDTEDKLKGAREENSGLLQELE 1062
Query: 1269 EAFHFSQKTQENTSSEQTGSSSFIPQLVQLSFTSLASAESGTILEPLFTESESKIFSSHL 1328
E + K + ++E + + Q+ + +LAS E + ++L
Sbjct: 1063 ELRKQADKAKAAQTAED--AMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNL 1120
Query: 1329 QIPQLQDRLLRISQLIQPQQDNLKALQEQLATQREAIILARQE--AREELLLHQSEWEGR 1386
+ + L + +L+ + ++ ++++ T ++A Q+ A +E + +E GR
Sbjct: 1121 KNVE---ELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGR 1177
Query: 1387 ISPEQVDTSSLPLVPQHSFASLPLNESERNQEPCSINSDNIVSSGHSEIPTLPDGLLGLS 1446
E TS L + S + L E ++ + ++D +S I ++
Sbjct: 1178 SRDEV--TSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSI--------SIT 1227
Query: 1447 HLVLPQQDNLIALEEHLHAQTDFLPSIEKTQKELVLSKPCKFEEKVSSEHFIQSHHGDLQ 1506
+L ++D +EK + E+ + + E S++ L
Sbjct: 1228 SALLTEKD----------------AELEKLRNEVTVLRG----ENASAK--------SLH 1259
Query: 1507 ALQQQLDTQKKAIRSIQEVQEELLLQRLSELEKRVSSEQVCSSSFVSQVPVADSERTQKS 1566
++ Q L++ K V+ EL ++ L EL+ + + Q+ SSS + + ER Q+S
Sbjct: 1260 SVVQTLESDK--------VKLELKVKNL-ELQLKENKRQLSSSSGNTDTQADEDERAQES 1310
Query: 1567 FPTKSNDTLPSSHREIPRLQDRLLSLSKPILPQQDNMTAQLDAQREVMYSYEKPQ 1621
N + R+ L+ ++ +S+ L + D+ + S +KP+
Sbjct: 1311 QIDFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSKKKPR 1365
Score = 41.6 bits (96), Expect = 0.010
Identities = 99/468 (21%), Positives = 193/468 (41%), Gaps = 62/468 (13%)
Query: 22 LKEDYERRRKL---RLLQVREQERDIALQIREDIKQ--RRNQQFTRLAEELRA------- 69
+KE E+ ++ + + E+ + ++E + + ++ +QF L+ +L
Sbjct: 834 VKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLAD 893
Query: 70 ------EWEESQTQKIQNLEKLY--LASLRSM-GEGHRQAKENEPDLDALAQRAAERKRK 120
E +E + Q I+ EKL +A + M G+ Q + +L + E + K
Sbjct: 894 MEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLK 953
Query: 121 ADLRHKEALKVQKNQKEILLKQKTWHIKARKEALLVEKERSAKITSLPPPPPTLFENI-E 179
++ A +QK+ +++ +K + +A K+ +KE K++ L T E
Sbjct: 954 LTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQE 1013
Query: 180 VKRISAVKTNSSTYHHLHTFVN-----RETDTKRPDARLAAEEEAKRLEELQKQAAQERM 234
+K T+ + H N +T+ K AR + LEEL+KQA
Sbjct: 1014 LKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQA----- 1068
Query: 235 ERFEKAHVRGFQAMKKIHLAQNQEKLMKELKQLQQEDLAR---RRQTVAQMPPQLVELPY 291
+KA K A++ ++M+++ + + E LA +QT A++ +L L
Sbjct: 1069 ---DKA--------KAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKE 1117
Query: 292 KRSEMKEDWQRELEFAFEDMYNADRKVKGNLILHLEPEPLPTVTNQIQDEELDLSMEQEN 351
+ E+ + E + + K E E L Q + ++L ++++EN
Sbjct: 1118 NNLKNVEELNKSKELLTVENQKMEEFRK-------EIETLKQAAAQ-KSQQLS-ALQEEN 1168
Query: 352 LGAAEDLPVTEAEICSSE--TDVPLVMKTQQIPSKVLFKKLLNKIRSQKSLWTIKSMSED 409
+ AE+L + E+ S + + V+ Q + K K + +K+ KS+S
Sbjct: 1169 VKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQ-KSISIT 1227
Query: 410 ESEMITTVSEIES--KAPTVESGTIASKERTLSSGQEQVVESDTLTIE 455
+ + +E+E TV G AS + S Q +ESD + +E
Sbjct: 1228 SALLTEKDAELEKLRNEVTVLRGENASAKSLHS--VVQTLESDKVKLE 1273
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 67.0 bits (162), Expect = 2e-10
Identities = 189/884 (21%), Positives = 345/884 (39%), Gaps = 130/884 (14%)
Query: 54 QRRNQQFTRLAEELRAE--WEESQTQKIQNLEKLYLASLRSMGEGHRQAKENEPDLDALA 111
++ NQ+ ++ E L E E+ Q QNL K + + + +EN +
Sbjct: 497 EKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKIL 556
Query: 112 QRAAERKRK--ADLRHKEALKVQKNQKEILLKQKTWHIKARKEALLVEKERSAKITSLPP 169
++ E + + LR + + + K+I + K H E++ KE S+K++ +
Sbjct: 557 EQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILH-----ESI---KETSSKLSKIEF 608
Query: 170 PPPTLFENIEVKRISAVKTNS--STYHHLHTFVNRETDTKRPDARLAAEEEAKRLEELQK 227
+ + +E + + + HHL N K + ++ E ++E L++
Sbjct: 609 EKRQIKKELEHYKEKGERAEELENELHHLEK-ENELLQKKITNLKITCE----KIEALEQ 663
Query: 228 QAAQ-ERMERFEKAHVRGFQAMKKIHLAQNQEKLMKELKQLQQEDLARRRQT----VAQM 282
+ ++ ER R K + F+ +L E L KE QL +E+L RR A M
Sbjct: 664 ENSELERENRKLKKTLDSFK-----NLTFQLESLEKENSQLDEENLELRRNVESLKCASM 718
Query: 283 PPQLVELPYKRSEM-KEDWQRELEFAFEDMYNADRKVKGNLILHLEPEPLP-TVTN---- 336
++L K E KE ++ LE +R L +E + L T+ N
Sbjct: 719 KMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKK 778
Query: 337 --QIQDEELDLSMEQENLGA-AEDLPVTEAEICSSETD-VPLVMKTQQIPS-KVLFKKLL 391
Q++ E DL ME + L E+L ++ + E + L +T Q+ K +K
Sbjct: 779 IQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKEN 838
Query: 392 NKIRSQKSLWTIKSMSEDESEMITTVSEIESKAPTVESGTIAS---KERTLSSGQEQVVE 448
++R Q IK + +E+ + E E+K + E G + + L +++V+
Sbjct: 839 KRLRQQAE---IKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVK 895
Query: 449 SDTLTIESGPLASEDKPLSCGTNSGKEQEINETLPITTVAQSSV------LLHPQEAAAR 502
T+ I++ ED + K Q++N L T + LLH +++
Sbjct: 896 RATIDIKTLVTLREDLV----SEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDD 951
Query: 503 IR-------MSARQKQIMEIEEQKQKQLEL-LEQIEQ--QKLRLETDCFRAQLEEEKRKK 552
R + + K+ +EI+E+K LE LE+ Q+LR E + E K+++
Sbjct: 952 SRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQ 1011
Query: 553 TQPTGVGIAPASCPVISDEDSHRQMIRNYQHQLLQQNRLHRQSVETARKQLLEYQTMLKG 612
+ V S P IS ED N+ R+S ET R+ L +++
Sbjct: 1012 DEERMV----QSSPPISGED----------------NKWERESQETTRELLKVKDRLIE- 1050
Query: 613 RCPSVSAPSLITDSVISVPSWKSERPTAISEHWDQGQRLKLSPNKYQPIQPIQTSKLEQD 672
+ + ++ + K T + + Q L+ Q QT L++
Sbjct: 1051 ----------VERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQR----QTVSLQEQ 1096
Query: 673 HFQVARQNHFPQRQVETTETLRASDILTNQ---ALESQEHLRQFSQTETQQRD-----YK 724
+ + QN + QVE + S L NQ L Q L +++ ++R+ Y
Sbjct: 1097 NTTLQTQN--AKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYD 1154
Query: 725 LVPKDSETLSRALSHDRQLISQDARKISETFGATTFQSLESQ---------QLFSENS-- 773
+ KD E L L H+RQ ++ + ++LE + QL +
Sbjct: 1155 SLIKDHEKLE--LLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQL 1212
Query: 774 ENISYHL-TEPSSFVPLVPQHSFSSLPVKV---ESGKIQEPFSAMSKST--VSTSHSIIS 827
E++ L E + H + K E+ ++ +S + K T + T H +
Sbjct: 1213 EDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLK 1272
Query: 828 QMHDRPLLPSENITAQQGNMKALQEQLDLQKKVLQATQEAQEQL 871
+ + L + A+ +K +QLD+ L E QL
Sbjct: 1273 SLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQL 1316
Score = 49.7 bits (117), Expect = 4e-05
Identities = 182/1012 (17%), Positives = 388/1012 (38%), Gaps = 184/1012 (18%)
Query: 67 LRAEWEESQTQKI---QNLEKLYLASLRSMGEGH------RQAKENEPDLDALAQRAAER 117
LR E EE Q + Q LE++ + R E R A+ +LDAL ++A
Sbjct: 263 LRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAV-- 320
Query: 118 KRKADLRHKEALKVQKNQKEI-LLKQKTWHIKARKEALLVEKERSAKITSLPPPPPTLFE 176
+ D E + ++ +I K + +K + LL K T+ E
Sbjct: 321 --RVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETK--------------TMLE 364
Query: 177 NIEVKRISAVKTNSSTYHHLHTFVNRETDTKRPDARLAAEEEAKRLEELQKQAAQERMER 236
+ ++ + S H L N + K D + + + K++EEL ++ M +
Sbjct: 365 D----QLEGTRARSDKLHELEK-ENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQ 419
Query: 237 FEKAHVRGFQAMKKIHLAQNQEKLMK--ELKQLQQEDLARRRQTVAQMPPQLVELPYKRS 294
+ + +HL E++ + EL + Q+ L ++ EL R
Sbjct: 420 KQSMD-------ESLHLGWELEQISRTSELSEAPQKSLGH----------EVNELTSSRL 462
Query: 295 EMKEDWQRELEFAFEDMYNADRKVKGNL--ILHLEPEPLPTVTNQIQDEELDLSMEQENL 352
E + L E++ V+GN IL +E E ++ +++ E ++ E+++L
Sbjct: 463 LKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKEN-QRLSKKVEILENEIVQEKQSL 521
Query: 353 ----GAAEDLPVTEAEICSSETDVPLVMKTQQIPSKVL------FKKLLNKIRSQKSLWT 402
++DL +A++ E + + + + K+L + ++ +R + +
Sbjct: 522 QNCQNLSKDLMKEKAQL---EKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISA 578
Query: 403 ---IKSMSEDESEMITTVSEIESKAPTVESGTIASKERTLSSGQEQVVESDTLTIESGPL 459
+K + ++ + ++ E SK +E K+ L +E+ ++ L E L
Sbjct: 579 EARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKE-LEHYKEKGERAEELENELHHL 637
Query: 460 ASEDKPL---------SCGTNSGKEQEINE------------------TLPITTVAQSSV 492
E++ L +C EQE +E T + ++ + +
Sbjct: 638 EKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENS 697
Query: 493 LLHPQEAAAR----------IRMSARQKQIMEIEEQKQ---KQLELLEQIEQQKLRLETD 539
L + R ++M+ Q + E+E +K+ K LELL+ ++ RLE
Sbjct: 698 QLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVS 757
Query: 540 CFRAQLEEEKRKKTQPTGVGIAPASCPVISDEDSHRQMIRNYQHQL------LQQNRLHR 593
+E ++ +KT + D + Q ++ +L L+Q
Sbjct: 758 YQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKEN 817
Query: 594 QSVETARKQLLEYQTMLKGRCPSVSAPSLITDSVISVPSWKSERPTAISEHWDQGQRLKL 653
+S+E QL + + L+ + + I D+ + E I + + L
Sbjct: 818 KSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTL------EENNVKIGNLEKENKTLSK 871
Query: 654 SPNKYQPIQPIQTSKLEQDHFQVARQNHFPQRQVETTETLRASDILTNQALESQEHLRQF 713
Y+ ++ +LE+++ ++ ++ ++T TLR + L ++ L++Q+
Sbjct: 872 EIGIYKE-SCVRLKELEKENKELVKRATI---DIKTLVTLR--EDLVSEKLKTQQ----- 920
Query: 714 SQTETQQRDYKLVPKDSETL---SRALSHDRQLISQDARKISETFGATTFQSLESQQLFS 770
D + + + E + L HD Q K+ E+ +T + +S ++
Sbjct: 921 -----MNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLK--KSLEIKE 973
Query: 771 ENSENISYHLTEPSSFVPLVPQH------SFSSLPVKVESGKIQEPFSAMS-------KS 817
E + L E +++ + Q ++ +L + + ++ + +S +
Sbjct: 974 EKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERE 1033
Query: 818 TVSTSHSIISQMHDRPLLPSENITAQQGNMKALQEQLDLQKKVLQATQEAQEQLLLCKQK 877
+ T+ ++ ++ DR + N Q +AL+ QL K++ Q Q+L +++
Sbjct: 1034 SQETTRELL-KVKDRLIEVERNNATLQAEKQALKTQL---KQLETQNNNLQAQILALQRQ 1089
Query: 878 EV---EQQTGLSVFLPLVTPDSSALLPSAKADLGR-----IQESSPTKNNIAV------- 922
V EQ T L + ++S L + + + + IQ+SS N +V
Sbjct: 1090 TVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDL 1149
Query: 923 -------SSDHHVISQLQDKRLSLSQPILSQQNNFKFLQEQLNIQKDSLQAR 967
DH + L +++ S + ++S+ K + L ++ L+ R
Sbjct: 1150 KSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDR 1201
Score = 44.7 bits (104), Expect = 0.001
Identities = 182/914 (19%), Positives = 363/914 (39%), Gaps = 160/914 (17%)
Query: 925 DHHVISQLQDKRLSLSQPILSQQNNFKFLQEQLNIQKDSLQARR-----EAQEVLYVHKQ 979
D I +L ++ ++L ++Q+ + + E L++ + Q R EA + H+
Sbjct: 401 DRKKIEELMEENMTLE---MAQKQS---MDESLHLGWELEQISRTSELSEAPQKSLGHEV 454
Query: 980 SEL-DRRVCSEQAEPSFPFQVAQHTFTSLPSADTKSGKI--QEQHSSKSEKGLVSCQSDI 1036
+EL R+ + E + + T++ S + + KI E+ + + K + +++I
Sbjct: 455 NELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEI 514
Query: 1037 PISQDGSLSFLQQFLPLHDSLKLLQEQLTKQRDTLQARHEAQVELLLHRQRDLGDSKSGL 1096
+ + SL Q L L + QL K +TL+ E Q+++L L + S L
Sbjct: 515 -VQEKQSLQNCQN---LSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSL 570
Query: 1097 -----------VSSSSSPVVVQHSVASQASAKA-----EPRRIQ---------------- 1124
V + H + S+K E R+I+
Sbjct: 571 RQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEEL 630
Query: 1125 --ELYLSEKENVGPSCHLIIPTFQDKSLSFPQHSLAQQENLTILQEQSQIQRVILGAKEG 1182
EL+ EKEN L+ + ++ + +QEN + +E ++++ + K
Sbjct: 631 ENELHHLEKEN-----ELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNL 685
Query: 1183 TQEFVHTESELEKRISSEQTGTSSSLSQVDESERFQECISIKSDSTIPLSHPKIPRCQER 1242
T + E E +S+ + L + ES + C S+K + + L + ++ +E+
Sbjct: 686 TFQLESLEKE-----NSQLDEENLELRRNVESLK---CASMKM-AQLQLENKELESEKEQ 736
Query: 1243 L---LRVSQHMLPLQDNLEEHQAWLDTEKEAFHFSQKTQENTSSEQTGSSSFIPQLVQLS 1299
L L + + + LE LD E + QKT EN++ + S + L
Sbjct: 737 LKKGLELLKASFKKTERLEVSYQGLDIENQRL---QKTLENSNKKIQQLESELQDL---- 789
Query: 1300 FTSLASAESGTILEPLFTESESKIFSSHLQIPQLQDRLLRISQLIQPQQDNLKALQEQLA 1359
E+ T+ + L E KI S L+ QL+ + Q + + K L+++
Sbjct: 790 -----EMENQTLQKNL---EELKISSKRLE--QLEKENKSLEQETSQLEKDKKQLEKENK 839
Query: 1360 TQREAIILARQEAREELLLHQSEWEGRISPEQVDTSSLPLVPQHSFASLPLNESERNQ-- 1417
R+ + E ++ L + G + E S + + S L E E +
Sbjct: 840 RLRQ-----QAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELV 894
Query: 1418 EPCSINSDNIVS------SGHSEIPTLPDGLLGLSHLVLPQQDNLIALEEHLHAQTDFLP 1471
+ +I+ +V+ S + + + L L+H + N L + D
Sbjct: 895 KRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRY 954
Query: 1472 SIEKTQKELVLSKPCKF-EEKVSS-EHFIQSHHGDLQALQQQLDTQKKAIRSIQEVQEEL 1529
+ +++ E L K + EEK+++ E ++ Q L+Q+L T KK ++++ Q+E
Sbjct: 955 KLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDE- 1013
Query: 1530 LLQRLSELEKRVSSEQVCSSSFVSQVPVADSERTQKSFPTKSNDTLPSSHREIPRLQDRL 1589
+R+ + +S E D++ ++S T RE+ +++DRL
Sbjct: 1014 --ERMVQSSPPISGE--------------DNKWERESQETT---------RELLKVKDRL 1048
Query: 1590 LSLSKPILPQQDNMTAQLDAQREVMYSYEKPQEELSLNKQRKLNKSESAEHTIPSLFLPK 1649
+ + + A L A+++ + + K E + N Q ++ + ++
Sbjct: 1049 IEV--------ERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTL 1100
Query: 1650 ETEHSFIPLPFAEAKPKSTCELYSSQNEHAAPPSNPVIPGFQDRLLSFSQSVLTQQDNLG 1709
+T+++ + + + +ST S N++A L QS L ++
Sbjct: 1101 QTQNAKLQVENSTLNSQST----SLMNQNAQ--------------LLIQQSSLENENESV 1142
Query: 1710 LQKQLDLQREVLHYSQKAQEK--LLVQRQTALQQQIQKHEETLKDFFKDSQISKPTVE-- 1765
++++ DL + + K EK LL +RQ + + + TLK K+ ++ +E
Sbjct: 1143 IKEREDL-KSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDR 1201
Query: 1766 -NDLKTQKMGQLRD 1778
N L QK GQL D
Sbjct: 1202 YNQLLKQK-GQLED 1214
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 65.5 bits (158), Expect = 7e-10
Identities = 150/756 (19%), Positives = 308/756 (40%), Gaps = 87/756 (11%)
Query: 1055 DSLKLLQEQLTKQRDTLQARHEAQVELLLHRQRDLGDSKSGLVSSSSSPVVVQHSVASQA 1114
+ ++ +QL ++++ L + +A+ EL + + ++ L + + H + S+
Sbjct: 876 EEMERKHQQLLEEKNILAEQLQAETELFAEAE----EMRARLAAKKQELEEILHDLESRV 931
Query: 1115 SAKAEPRRIQELYLSEKENVGPSCHLIIPTFQDKSLSFPQHSLAQQ----ENLTILQEQS 1170
+ E +I + +EK+ + H+ QD + A+Q E +T +
Sbjct: 932 EEEEERNQILQ---NEKKKM--QAHI-----QDLEEQLDEEEGARQKLQLEKVTAEAKIK 981
Query: 1171 QIQRVILGAKEGTQEFVHTESELEKRISSEQTGTSSSLSQVDESERFQECISIKSDSTIP 1230
+++ IL ++ +F+ + +E RI+ SS L++ E E+ + I++ +
Sbjct: 982 KMEEEILLLEDQNSKFIKEKKLMEDRIAE----CSSQLAE--EEEKAKNLAKIRNKQEVM 1035
Query: 1231 LSH-----PKIPRCQERLLRVSQHM----LPLQDNLEEHQAWLDTEKEAFHFSQKTQENT 1281
+S K + ++ L + + + LQD + E QA +D K ++K +E
Sbjct: 1036 ISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELK--LQLAKKEEELQ 1093
Query: 1282 SSEQTGSSSFIPQLVQLSFTSLASAESGTILEPLFTESESKIFSSHLQIPQLQDRLLRIS 1341
+ G + + L A+ + E +E S+ + Q L + L +
Sbjct: 1094 GALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRN-KAEKQKRDLSEELEALK 1152
Query: 1342 QLIQPQQDNLKALQEQLATQREAIILARQEA-REELLLHQSEWEG---RISPEQVDTSSL 1397
++ D A Q++L T+RE + ++A EE H+++ + R + + S
Sbjct: 1153 TELEDTLDTTAA-QQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQ 1211
Query: 1398 PLVPQHSFASLPLN----ESERNQEPCSINSDNIVSSGHSEIPTLPDGLLGLSHLVLPQQ 1453
+ A+L N E++ + C + V + D + H + +
Sbjct: 1212 LEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEG 1271
Query: 1454 DNL-IALEEHLHAQTDFLPSIEKTQKELVLSKPCKFEEKVSSEHFIQSHHGDLQALQQQL 1512
D L + L E + L ++ T E K KF + +S ++S D Q L Q+
Sbjct: 1272 DRLRVELAEKASKLQNELDNVS-TLLEEAEKKGIKFAKDAAS---LESQLQDTQELLQEE 1327
Query: 1513 DTQK----KAIRSIQEVQEELLLQRLSELEKRVSSEQ----VCSSSFVSQVPVADSERTQ 1564
QK IR ++E + L Q+ E E R + E+ + S ++ V D T
Sbjct: 1328 TRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTI 1387
Query: 1565 KSFPTKSNDTLPSSHREIPRLQDRLLSLSK------PILPQQDNMTAQLDAQREVMYSYE 1618
+S L + RL+++ L+ K + + D++T LD QR+V + E
Sbjct: 1388 ESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLE 1447
Query: 1619 KPQEELSLNKQRKLNKSESAEHTIPSLFLPKETEHSFIPLPFAEAKPKSTCELYSSQNEH 1678
K KQ+K ++ + E +I + + + AEA+ K T L ++
Sbjct: 1448 K--------KQKKFDQLLAEEKSISARYAEERDRAE------AEAREKETKALSLARALE 1493
Query: 1679 AAPPSNPVIPGFQDRLLSFSQSVLTQQDNLGLQKQLDLQREVLHYSQKAQEKLLVQRQTA 1738
A + +L + + +++ +D++G L S++A E+ + + +T
Sbjct: 1494 EALEAKEEFERQNKQLRADMEDLMSSKDDVGKNV------HELEKSKRALEQQVEEMRTQ 1547
Query: 1739 LQQ---QIQKHEETLKDFFKDSQISKPTVENDLKTQ 1771
L++ ++Q E+ + Q K E DL+T+
Sbjct: 1548 LEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTR 1583
Score = 60.8 bits (146), Expect = 2e-08
Identities = 201/1078 (18%), Positives = 411/1078 (38%), Gaps = 207/1078 (19%)
Query: 34 LLQVREQERDIALQIREDIKQRRNQQFTRLAEELRAEWEESQTQKIQNLEKLYLASLRSM 93
LLQV QE ++ + E +K + Q T++ EL E E + Q++ + + L++
Sbjct: 844 LLQVTRQEEELQAKDEELLKVKEKQ--TKVEGEL--EEMERKHQQLLEEKNILAEQLQAE 899
Query: 94 GEGHRQAKENEPDLDALAQRAAERKRKADLR---HKEALKVQKNQKEILLKQKTWHIKAR 150
E +A+E L A Q E + R +E ++ +N+K K+ HI+
Sbjct: 900 TELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEK----KKMQAHIQDL 955
Query: 151 KEALLVEKERSAKITSLPPPPPTLFENIEVKRISAVKTNSSTYHHLHTFVNRETDTKRPD 210
+E L ++E A+ + +++++++A + + + ++K
Sbjct: 956 EEQL--DEEEGAR------------QKLQLEKVTAEAKIKKMEEEI--LLLEDQNSKFIK 999
Query: 211 ARLAAEEEAKRLEELQKQAAQERMERFEKAHVRGFQAMKKIHLAQNQEKLMKELKQLQQE 270
+ E+ R+ E Q A+E + A +R Q ++ ++ +E+L KE K Q+
Sbjct: 1000 EKKLMED---RIAECSSQLAEEEEKAKNLAKIRNKQ---EVMISDLEERLKKEEKTRQEL 1053
Query: 271 DLARRR---------QTVAQMPPQLVELPYKRSEMKEDWQRELEFAFEDMYNADRKVKGN 321
+ A+R+ +A++ Q+ EL + ++ +E+ Q L ++ + + +K
Sbjct: 1054 EKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVV 1113
Query: 322 LILHLEPEPLP-------TVTNQIQDEELDLSMEQENLGAAEDLPVTEAEICSSETDVPL 374
L + L N+ + ++ DLS E E L TE E T
Sbjct: 1114 RELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALK-------TELEDTLDTTAAQQ 1166
Query: 375 VMKTQQIPSKVLFKKLLNKIRSQKSLWTIKSMSEDESEMITTVSEIESKAPTVESGTIAS 434
++T++ KK L + ++ I+ M + + + +SE +A ++ +
Sbjct: 1167 ELRTKREQEVAELKKALEE-ETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKN 1225
Query: 435 KERTLSSGQEQVVESDTLTIESGPLASEDKPLSCGTNS--GKEQEINETLPITTVAQSSV 492
K+ + +E E L + K L K E + L + ++S
Sbjct: 1226 KQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSE-GDRLRVELAEKASK 1284
Query: 493 LLHPQEAAARIRMSARQKQIM------EIEEQKQKQLELLEQIEQQKLRLETDCFRAQLE 546
L + + + + A +K I +E Q Q ELL++ +QKL L + QLE
Sbjct: 1285 LQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRI--RQLE 1342
Query: 547 EEKRKKTQPTGVGIAPASCPVISDEDSHRQMIRNYQHQLLQQNRLHRQSVETARKQLLEY 606
EEK + L +Q ++ + KQ+L
Sbjct: 1343 EEK---------------------------------NSLQEQQEEEEEARKNLEKQVLAL 1369
Query: 607 QTMLKGRCPSVSAPSLITDSVISVPSWKSERPTAISEHWDQGQRLKLSPNKYQPIQPIQT 666
Q+ L + D + ++ S + + + + QRL+ Y
Sbjct: 1370 QSQL------ADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAY-------- 1415
Query: 667 SKLEQDHFQVARQNHFPQRQVETTETLRASDILTNQALESQEHLRQF-SQTETQQRDYKL 725
KLE+ +N Q + T L +H RQ S E +Q+ +
Sbjct: 1416 DKLEK------TKNRLQQELDDLTVDL--------------DHQRQVASNLEKKQKKFDQ 1455
Query: 726 VPKDSETLSRALSHDRQLISQDARKISETFGATTFQSLESQQLFSENSENISYHLTEPSS 785
+ + +++S + +R +AR+ ET + ++LE
Sbjct: 1456 LLAEEKSISARYAEERDRAEAEARE-KETKALSLARALE--------------------- 1493
Query: 786 FVPLVPQHSFSSLPVKVESGKIQEPFSAMSKSTVSTSHSIISQMHDRPLLPSENITAQQG 845
+L K E + + A + +S+ + +H+ L S+ QQ
Sbjct: 1494 ----------EALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHE--LEKSKRALEQQ- 1540
Query: 846 NMKALQEQLDLQKKVLQATQEAQEQLLLCKQKEVEQQTGLSVFLPLVTPDSSALLPSAKA 905
++ ++ QL+ + LQAT++A+ +L EV Q A+ +
Sbjct: 1541 -VEEMRTQLEELEDELQATEDAKLRL------EVNMQ---------------AMKAQFER 1578
Query: 906 DLGRIQESSPTKNNIAVSSDHHVISQLQDKRLSLSQPILSQQN---NFKFLQEQLNIQKD 962
DL E + K + + + ++L+D+R + + S++ + K L+ Q+
Sbjct: 1579 DLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAAN- 1637
Query: 963 SLQARREAQEVL--YVHKQSELDRRVCSEQAEPSFPFQVAQHTFTSLPSADTKSGKIQEQ 1020
+AR E + L + + R + +A F ++ + L S + + ++QE+
Sbjct: 1638 --KARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEE 1695
Query: 1021 HSSK------SEKGLVSCQSDIPISQDGSLSFLQQFLPLHDSLKLLQEQLTKQRDTLQ 1072
+S +E+ +I S G + L + L + L+E+L +++ ++
Sbjct: 1696 LASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNME 1753
Score = 49.7 bits (117), Expect = 4e-05
Identities = 159/897 (17%), Positives = 345/897 (38%), Gaps = 132/897 (14%)
Query: 832 RPLLPSENITAQQGNMKALQEQL----DLQKKVLQATQEAQEQLLLCKQKEVEQQTGLSV 887
R L E +TA+ +K ++E++ D K ++ + ++++ C + E++
Sbjct: 966 RQKLQLEKVTAE-AKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKN 1024
Query: 888 FLPLVTPDSSALLPSAKADLG-RIQESSPTKNNIAVSSDHHVISQLQDKRLSLSQPILSQ 946
+ + +DL R+++ T+ + + +L + L I
Sbjct: 1025 LAKIRNKQEVMI-----SDLEERLKKEEKTRQELEKAK-----RKLDGETTDLQDQIAEL 1074
Query: 947 QNNFKFLQEQLNIQKDSLQAR--REAQEVLYVHKQSELDRRVCSEQAEPSFPFQVAQHTF 1004
Q L+ QL +++ LQ R E L+ + ++ R + ++ AE Q F
Sbjct: 1075 QAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAE-------LQEDF 1127
Query: 1005 TSLPSADTKSGKIQEQHSSKSEK---------GLVSCQSDIPISQDGSLSFLQQFLPLHD 1055
S ++ K+ K + S + E + Q ++ ++ ++ L++ L
Sbjct: 1128 ESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEET 1187
Query: 1056 SLKLLQEQLTKQRD-TLQARHEAQVELLLHRQRDLGDSKSGLVSSSSSPVVVQHSVASQA 1114
Q Q +QR T Q+E + +L +K GL + + + + V Q
Sbjct: 1188 KNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGL-ETDNKELACEVKVLQQV 1246
Query: 1115 SAKAEPRR------IQELY------------LSEK----ENVGPSCHLIIPTFQDKSLSF 1152
A++E +R +QEL+ L+EK +N + ++ + K + F
Sbjct: 1247 KAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKF 1306
Query: 1153 PQHSLAQQENLT----ILQEQSQIQ-------RVILGAKEGTQEFVHTESE----LEKRI 1197
+ + + + L +LQE+++ + R + K QE E E LEK++
Sbjct: 1307 AKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQV 1366
Query: 1198 SSEQTGTSSSLSQVDESERFQECISIKSDSTIPLSHPKIPRCQERLL----------RVS 1247
+ Q+ + + +VD+ E + + + R +E+ L R+
Sbjct: 1367 LALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQ 1426
Query: 1248 QHMLPLQDNLE-EHQAWLDTEKEAFHFSQKTQENTS-----SEQTGSSSFIPQLVQLSFT 1301
Q + L +L+ + Q + EK+ F Q E S +E+ + + +
Sbjct: 1427 QELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKAL 1486
Query: 1302 SLASAESGTILEPLFTESESKIFSSHLQ------------IPQLQDRLLRISQLIQPQQD 1349
SLA A + E ++K + ++ + +L+ + Q ++ +
Sbjct: 1487 SLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRT 1546
Query: 1350 NLKALQEQLATQREAIILARQEAREELLLHQSEWEGRISPEQVDTSSLPLVPQHSFASLP 1409
L+ L+++L +A + R E + + Q E + + EQ + L+ Q
Sbjct: 1547 QLEELEDELQATEDAKL--RLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAE 1604
Query: 1410 LNESERNQEPCSINSDNIVSSGHSEIPTLPDGLLGLSHLVLPQQDNLIALEEHLHAQTDF 1469
L E ER Q ++ S + ++ + +D +I L AQ
Sbjct: 1605 L-EDERKQRALAVASKKKMEIDLKDLEAQIEA-------ANKARDEVIKQLRKLQAQ--- 1653
Query: 1470 LPSIEKTQKELVLSKPCKFEEKVSSEHFIQSHHGDLQALQQQLDTQKKAIRSIQEVQEEL 1529
+ ++ +E S+ F + SE ++S ++ LQ++L + ++A R ++ ++EL
Sbjct: 1654 MKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDEL 1713
Query: 1530 LLQRLSELEKRVSSEQVCSSSFVSQVPVADSERTQKSFPTKSNDTLPSSHREIPRLQDRL 1589
++++ +S+ + + D +R ++ + + L + L DR
Sbjct: 1714 -------------ADEITNSA-SGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRF 1759
Query: 1590 LSLSKPILPQQDNMTAQLDAQREVMYSYEKPQEELSLNKQRKLNKSESAEHTIPSLF 1646
+ Q D + A+L A+R + +++L + K + E + S F
Sbjct: 1760 ----RKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKF 1812
Score = 49.7 bits (117), Expect = 4e-05
Identities = 112/515 (21%), Positives = 206/515 (40%), Gaps = 65/515 (12%)
Query: 46 LQIREDIKQRRNQQFTRLAEELRAEWEESQTQKIQNLEKLYLASLRSMGEGHRQAKEN-E 104
LQ +++ Q +Q L+ +R EE SL+ E +A++N E
Sbjct: 1317 LQDTQELLQEETRQKLNLSSRIRQLEEEKN-------------SLQEQQEEEEEARKNLE 1363
Query: 105 PDLDALAQRAAERKRKADLRHKEALKVQKNQKEILLKQKTWHIKARKEALLVEKERSAKI 164
+ AL + A+ K+K D +++ +K++L + + ++AL +K K
Sbjct: 1364 KQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTK- 1422
Query: 165 TSLPPPPPTLFENIEVKRISAVKTNSSTYHHLHTFVNRETDTKRPDARLAAEEE-AKRLE 223
L L +++ H N E K+ D LA E+ + R
Sbjct: 1423 NRLQQELDDLTVDLD--------------HQRQVASNLEKKQKKFDQLLAEEKSISARYA 1468
Query: 224 ELQKQAAQERMERFEKAHVRGFQAMKKIHLAQNQEKLMKELKQLQQEDLARRRQTVAQMP 283
E + +A E E+ KA + + + E+ K+L+ EDL + V +
Sbjct: 1469 EERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLR-ADMEDLMSSKDDVGKNV 1527
Query: 284 PQLVELPYKRSEMKEDWQRELEFAFEDMYNADRKVKGNLILHLE------PEPLPTVTNQ 337
+L + + E+ + +LE ED A K L ++++ L T Q
Sbjct: 1528 HELEKSKRALEQQVEEMRTQLE-ELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQ 1586
Query: 338 IQDEELDLSMEQENLGA-AEDLPVTEAEICSSETDVPLVMKTQQIPSKVLFKKLLNKIRS 396
++++ L + L A ED A +S+ + + +K + + NK R
Sbjct: 1587 NEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEA-----ANKARD 1641
Query: 397 QKSLWTIKSMSEDESEMITTVSEIESKAPTVESGTIASKERTLSSGQEQVVESDTLTIES 456
+ IK + + +++M E+E + + SKE S + + +E++ L ++
Sbjct: 1642 E----VIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKE---SEKKLKSLEAEILQLQE 1694
Query: 457 GPLASEDKPLSCGTNSGKEQEINETLPITTVAQS--SVLLHPQEAAARIRMSARQKQIME 514
LAS ++ EQE +E T + S S LL + R+ AR Q+ E
Sbjct: 1695 -ELASSER-----ARRHAEQERDELADEITNSASGKSALLDEKR-----RLEARIAQLEE 1743
Query: 515 IEEQKQKQLELLEQIEQQKLRLETDCFRAQLEEEK 549
E++Q +ELL +K L+ D A+L E+
Sbjct: 1744 ELEEEQSNMELLND-RFRKTTLQVDTLNAELAAER 1777
Score = 43.1 bits (100), Expect = 0.004
Identities = 169/911 (18%), Positives = 351/911 (38%), Gaps = 104/911 (11%)
Query: 504 RMSARQKQIMEIEEQKQ----KQLELLEQIEQQKLRLETDCFRAQLEEEKRKKTQPTGVG 559
++ A + E EE + K+ EL E + + R+E + R Q+ + ++KK Q
Sbjct: 895 QLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQD 954
Query: 560 IAPASCPVISDEDSHRQMIRNYQHQLLQQNRLHRQSVETARKQLLEYQTMLKGR-CPSVS 618
+ + +E+ RQ + +L + + E K++ E +L+ + +
Sbjct: 955 LEEQ----LDEEEGARQKL-----------QLEKVTAEAKIKKMEEEILLLEDQNSKFIK 999
Query: 619 APSLITDSVISVPSWKSERPTAISEHWDQGQRLKLSPNKYQPIQPIQTSKLEQ--DHFQV 676
L+ D + +E + ++E ++ + L NK Q + S LE+ +
Sbjct: 1000 EKKLMEDRI-------AECSSQLAEEEEKAKNLAKIRNK----QEVMISDLEERLKKEEK 1048
Query: 677 ARQNHFPQRQVETTETLRASDILTNQALESQEHLRQFSQTETQQRDYKLVPKDSETL--S 734
RQ ++ ET D + + E Q ++ E ++ L D ETL +
Sbjct: 1049 TRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKE-EELQGALARGDDETLHKN 1107
Query: 735 RALSHDRQLISQDARKISETFGATTFQSLESQQLFSENSENISYHLTEPSSFVPLVPQHS 794
AL R+L +Q A ++ E F + ++++ + SE + TE +
Sbjct: 1108 NALKVVRELQAQIA-ELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQ- 1165
Query: 795 FSSLPVKVESGKIQEPFSAMSKSTVSTSHSIISQMHDRPLLPSENITAQQGNMKALQEQL 854
L K E ++ E A+ + T + I M R E ++ Q K + L
Sbjct: 1166 -QELRTKREQ-EVAELKKALEEET-KNHEAQIQDMRQRHATALEELSEQLEQAKRFKANL 1222
Query: 855 DLQK--------------KVLQ---ATQEAQEQLLLCKQKEVEQQTGLSVFLPLVTPDSS 897
+ K KVLQ A E + + L + +E+ + L + + +
Sbjct: 1223 EKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKA 1282
Query: 898 ALLPSAKADLGRIQESSPTKNNIAVSSDHHVISQLQDKRLSLSQPILSQQNNFKFLQEQL 957
+ L + ++ + E + K + SQLQD + L Q Q+ N QL
Sbjct: 1283 SKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQ-ELLQEETRQKLNLSSRIRQL 1341
Query: 958 NIQKDSLQARREAQEVLYVHKQSELDRRVC---SEQAEPSFPFQVAQHTFTSLPSADTKS 1014
+K+SLQ ++E +E + L+++V S+ A+ T SL A K
Sbjct: 1342 EEEKNSLQEQQEEEE----EARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKL 1397
Query: 1015 GKIQEQHSSKSEK------GLVSCQSDIPISQDGSLSFLQQFLPLHDSLKLLQ---EQLT 1065
K E S + E+ L ++ + D L + +L+ Q +QL
Sbjct: 1398 LKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLL 1457
Query: 1066 KQRDTLQARHEAQVELLLHRQRDLGDSKSGLVSSSSSPVVVQHSVASQASAKAEPRRIQ- 1124
+ ++ AR+ + R R +++ + S ++ ++ ++ + + ++++
Sbjct: 1458 AEEKSISARYAEE------RDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRA 1511
Query: 1125 --ELYLSEKENVGPSCHLIIPTFQDKSLSFPQHSLAQQENLTILQEQSQIQRVILGAKEG 1182
E +S K++VG + H + + Q + L L+++ Q E
Sbjct: 1512 DMEDLMSSKDDVGKNVH----ELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEV 1567
Query: 1183 TQEFVHTESELEKRISSEQTGTSSSL--SQVD------ESERFQECISIKSDSTIPLS-- 1232
+ + + E + + EQ L QV E ER Q +++ S + +
Sbjct: 1568 NMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLK 1627
Query: 1233 --HPKIPRCQERLLRVSQHMLPLQDNLEEHQAWLD----TEKEAFHFSQKTQENTSSEQT 1286
+I + V + + LQ ++++Q L+ + E F S+++++ S +
Sbjct: 1628 DLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEA 1687
Query: 1287 GSSSFIPQLVQLSFTSLASAESGTILEPLFTESESKIFSSHLQIPQLQDRLLRISQLIQP 1346
+L + + L T S S + + +L+ R+ ++ + ++
Sbjct: 1688 EILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEE 1747
Query: 1347 QQDNLKALQEQ 1357
+Q N++ L ++
Sbjct: 1748 EQSNMELLNDR 1758
>gi|52145312 hypothetical protein LOC118611 [Homo sapiens]
Length = 699
Score = 63.9 bits (154), Expect = 2e-09
Identities = 50/184 (27%), Positives = 93/184 (50%), Gaps = 14/184 (7%)
Query: 2421 LEEKSENEAKCFFQVSEFLPLVSATEASDYPAVSELSIEKPRTASTETPRRLTPVPGSLQ 2480
++E ++E + S P + + + P +SE E S +TP R +LQ
Sbjct: 523 IKECKKSEDPTTPEPSPAAPSPAPRDGAGSPGLSEDCSE-----SQQTPARSL----TLQ 573
Query: 2481 EAFIKRKKSFMERSHQRQKEIRNKIHVSENSQIKTVKEKPS---ISSSVSRLKGVNKVRA 2537
EA RK F+ RS +R K++ + + + + + +++K S I +S + + +
Sbjct: 574 EALEVRKPQFISRSQERLKKLEHMVQQRKAQRKEDLRQKQSLLPIRTSKKQFTIPHPLSD 633
Query: 2538 SF--PEDRKTTQALRHQRGLRLYNQLAEVKQQKEEKTKQEAYAQNRARAKEFHKKTLEKL 2595
+ P++R ++ H R R+Y+ L EVK++KEE+ K+ NR RA+ F K+ L++L
Sbjct: 634 NLFKPKERCISEKEMHMRSKRIYDNLPEVKKKKEEQRKRVILQSNRLRAEVFKKQLLDQL 693
Query: 2596 RAKN 2599
+N
Sbjct: 694 LQRN 697
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.125 0.339
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 94,468,184
Number of Sequences: 37866
Number of extensions: 4356017
Number of successful extensions: 25593
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 49
Number of HSP's successfully gapped in prelim test: 727
Number of HSP's that attempted gapping in prelim test: 18312
Number of HSP's gapped (non-prelim): 6150
length of query: 2601
length of database: 18,247,518
effective HSP length: 119
effective length of query: 2482
effective length of database: 13,741,464
effective search space: 34106313648
effective search space used: 34106313648
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 71 (32.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.