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Search of human proteins with 157837985
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|157837985 kazrin isoform E [Homo sapiens]
(775 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|157837985 kazrin isoform E [Homo sapiens] 1526 0.0
gi|63147424 kazrin isoform A [Homo sapiens] 790 0.0
gi|65301130 kazrin isoform B [Homo sapiens] 656 0.0
gi|65301128 kazrin isoform C [Homo sapiens] 613 e-175
gi|63999741 kazrin isoform C [Homo sapiens] 613 e-175
gi|29171753 PTPRF interacting protein alpha 1 isoform a [Homo sa... 202 1e-51
gi|4505983 PTPRF interacting protein alpha 1 isoform b [Homo sap... 202 1e-51
gi|32189362 PTPRF interacting protein alpha 3 [Homo sapiens] 186 9e-47
gi|55769554 protein tyrosine phosphatase, receptor type, f polyp... 179 1e-44
gi|29171755 PTPRF interacting protein alpha 2 [Homo sapiens] 177 3e-44
gi|170784854 PTPRF interacting protein, binding protein 2 (lipri... 169 1e-41
gi|29294627 PTPRF interacting protein binding protein 1 isoform ... 158 2e-38
gi|190341068 forkhead-associated (FHA) phosphopeptide binding do... 63 9e-10
gi|45439327 periplakin [Homo sapiens] 59 1e-08
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap... 58 3e-08
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 58 3e-08
gi|38044112 restin isoform b [Homo sapiens] 58 4e-08
gi|4506751 restin isoform a [Homo sapiens] 58 4e-08
gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens] 57 5e-08
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 57 7e-08
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 57 7e-08
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 56 1e-07
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 56 1e-07
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 56 1e-07
gi|116008447 CAP-GLY domain containing linker protein 2 isoform ... 55 2e-07
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 55 2e-07
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 55 2e-07
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 55 2e-07
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 55 2e-07
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 55 2e-07
>gi|157837985 kazrin isoform E [Homo sapiens]
Length = 775
Score = 1526 bits (3951), Expect = 0.0
Identities = 775/775 (100%), Positives = 775/775 (100%)
Query: 1 MMEDNKQLALRIDGAVQSASQEVTNLRAELTATNRRLAELSGGGGPGPGPGAAASASAAG 60
MMEDNKQLALRIDGAVQSASQEVTNLRAELTATNRRLAELSGGGGPGPGPGAAASASAAG
Sbjct: 1 MMEDNKQLALRIDGAVQSASQEVTNLRAELTATNRRLAELSGGGGPGPGPGAAASASAAG 60
Query: 61 DSAATNMENPQLGAQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATEL 120
DSAATNMENPQLGAQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATEL
Sbjct: 61 DSAATNMENPQLGAQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATEL 120
Query: 121 RVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNY 180
RVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNY
Sbjct: 121 RVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNY 180
Query: 181 EQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAEL 240
EQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAEL
Sbjct: 181 EQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAEL 240
Query: 241 AMAKQSLATLTKDVPKRHSLAMPGETVLNGNQEWVVQADLPLTAAIRQSQQTLYHSHPPH 300
AMAKQSLATLTKDVPKRHSLAMPGETVLNGNQEWVVQADLPLTAAIRQSQQTLYHSHPPH
Sbjct: 241 AMAKQSLATLTKDVPKRHSLAMPGETVLNGNQEWVVQADLPLTAAIRQSQQTLYHSHPPH 300
Query: 301 PADRQAVRVSPCHSRQPSVISDASAAEGDRSSTPSDINSPRHRTHSLCNGDSPGPVQKNL 360
PADRQAVRVSPCHSRQPSVISDASAAEGDRSSTPSDINSPRHRTHSLCNGDSPGPVQKNL
Sbjct: 301 PADRQAVRVSPCHSRQPSVISDASAAEGDRSSTPSDINSPRHRTHSLCNGDSPGPVQKNL 360
Query: 361 HNPIVQSLEDLEDQKRKKKKEKMGFGSISRVFARGKQRKSLDPGLFDDSDSQCSPTRQSL 420
HNPIVQSLEDLEDQKRKKKKEKMGFGSISRVFARGKQRKSLDPGLFDDSDSQCSPTRQSL
Sbjct: 361 HNPIVQSLEDLEDQKRKKKKEKMGFGSISRVFARGKQRKSLDPGLFDDSDSQCSPTRQSL 420
Query: 421 SLSEGEEQMDRLQQVELVRTTPMSHWKAGTVQAWLEVVMAMPMYVKACTENVKSGKVLLS 480
SLSEGEEQMDRLQQVELVRTTPMSHWKAGTVQAWLEVVMAMPMYVKACTENVKSGKVLLS
Sbjct: 421 SLSEGEEQMDRLQQVELVRTTPMSHWKAGTVQAWLEVVMAMPMYVKACTENVKSGKVLLS 480
Query: 481 LSDEDLQLGLGVCSSLHRRKLRLAIEDYRDAEAGRSLSKAAELDHHWVAKAWLNDIGLSQ 540
LSDEDLQLGLGVCSSLHRRKLRLAIEDYRDAEAGRSLSKAAELDHHWVAKAWLNDIGLSQ
Sbjct: 481 LSDEDLQLGLGVCSSLHRRKLRLAIEDYRDAEAGRSLSKAAELDHHWVAKAWLNDIGLSQ 540
Query: 541 YSQAFQNHLVDGRMLNSLMKRDLEKHLNVSKKFHQVSILLGIELLYQVNFSREALQERRA 600
YSQAFQNHLVDGRMLNSLMKRDLEKHLNVSKKFHQVSILLGIELLYQVNFSREALQERRA
Sbjct: 541 YSQAFQNHLVDGRMLNSLMKRDLEKHLNVSKKFHQVSILLGIELLYQVNFSREALQERRA 600
Query: 601 RCETQNIDPVVWTNQRVLKWVRDIDLKEYADNLTNSGVHGAVLVLEPTFNAEAMATALGI 660
RCETQNIDPVVWTNQRVLKWVRDIDLKEYADNLTNSGVHGAVLVLEPTFNAEAMATALGI
Sbjct: 601 RCETQNIDPVVWTNQRVLKWVRDIDLKEYADNLTNSGVHGAVLVLEPTFNAEAMATALGI 660
Query: 661 PSGKHILRRHLAEEMSAVFHPANSTGIREAERFGTPPGRASSVTRAGKEENSSGLKYKAG 720
PSGKHILRRHLAEEMSAVFHPANSTGIREAERFGTPPGRASSVTRAGKEENSSGLKYKAG
Sbjct: 661 PSGKHILRRHLAEEMSAVFHPANSTGIREAERFGTPPGRASSVTRAGKEENSSGLKYKAG 720
Query: 721 RLPLGKIGRGFSSKDPDFHDDYGSLQNEDCGDDDPQSRLEQCRLEGYNSLEVTNV 775
RLPLGKIGRGFSSKDPDFHDDYGSLQNEDCGDDDPQSRLEQCRLEGYNSLEVTNV
Sbjct: 721 RLPLGKIGRGFSSKDPDFHDDYGSLQNEDCGDDDPQSRLEQCRLEGYNSLEVTNV 775
>gi|63147424 kazrin isoform A [Homo sapiens]
Length = 421
Score = 790 bits (2041), Expect = 0.0
Identities = 407/407 (100%), Positives = 407/407 (100%)
Query: 1 MMEDNKQLALRIDGAVQSASQEVTNLRAELTATNRRLAELSGGGGPGPGPGAAASASAAG 60
MMEDNKQLALRIDGAVQSASQEVTNLRAELTATNRRLAELSGGGGPGPGPGAAASASAAG
Sbjct: 1 MMEDNKQLALRIDGAVQSASQEVTNLRAELTATNRRLAELSGGGGPGPGPGAAASASAAG 60
Query: 61 DSAATNMENPQLGAQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATEL 120
DSAATNMENPQLGAQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATEL
Sbjct: 61 DSAATNMENPQLGAQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATEL 120
Query: 121 RVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNY 180
RVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNY
Sbjct: 121 RVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNY 180
Query: 181 EQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAEL 240
EQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAEL
Sbjct: 181 EQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAEL 240
Query: 241 AMAKQSLATLTKDVPKRHSLAMPGETVLNGNQEWVVQADLPLTAAIRQSQQTLYHSHPPH 300
AMAKQSLATLTKDVPKRHSLAMPGETVLNGNQEWVVQADLPLTAAIRQSQQTLYHSHPPH
Sbjct: 241 AMAKQSLATLTKDVPKRHSLAMPGETVLNGNQEWVVQADLPLTAAIRQSQQTLYHSHPPH 300
Query: 301 PADRQAVRVSPCHSRQPSVISDASAAEGDRSSTPSDINSPRHRTHSLCNGDSPGPVQKNL 360
PADRQAVRVSPCHSRQPSVISDASAAEGDRSSTPSDINSPRHRTHSLCNGDSPGPVQKNL
Sbjct: 301 PADRQAVRVSPCHSRQPSVISDASAAEGDRSSTPSDINSPRHRTHSLCNGDSPGPVQKNL 360
Query: 361 HNPIVQSLEDLEDQKRKKKKEKMGFGSISRVFARGKQRKSLDPGLFD 407
HNPIVQSLEDLEDQKRKKKKEKMGFGSISRVFARGKQRKSLDPGLFD
Sbjct: 361 HNPIVQSLEDLEDQKRKKKKEKMGFGSISRVFARGKQRKSLDPGLFD 407
>gi|65301130 kazrin isoform B [Homo sapiens]
Length = 415
Score = 656 bits (1692), Expect = 0.0
Identities = 346/388 (89%), Positives = 349/388 (89%), Gaps = 9/388 (2%)
Query: 29 ELTATNRRLAELSGGGGPGPGPGAAAS---ASAAGDSAATNMENPQLGAQ------VLLR 79
+L A G GP PG AA AAG P++ A VLLR
Sbjct: 14 QLAAQGEPAPSCGAGAGPARPPGPAACEQCVDAAGPGDRPRAGVPRVRADGDCSQPVLLR 73
Query: 80 EEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQ 139
EEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQ
Sbjct: 74 EEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQ 133
Query: 140 AMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKD 199
AMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKD
Sbjct: 134 AMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKD 193
Query: 200 LLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPKRHS 259
LLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPKRHS
Sbjct: 194 LLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPKRHS 253
Query: 260 LAMPGETVLNGNQEWVVQADLPLTAAIRQSQQTLYHSHPPHPADRQAVRVSPCHSRQPSV 319
LAMPGETVLNGNQEWVVQADLPLTAAIRQSQQTLYHSHPPHPADRQAVRVSPCHSRQPSV
Sbjct: 254 LAMPGETVLNGNQEWVVQADLPLTAAIRQSQQTLYHSHPPHPADRQAVRVSPCHSRQPSV 313
Query: 320 ISDASAAEGDRSSTPSDINSPRHRTHSLCNGDSPGPVQKNLHNPIVQSLEDLEDQKRKKK 379
ISDASAAEGDRSSTPSDINSPRHRTHSLCNGDSPGPVQKNLHNPIVQSLEDLEDQKRKKK
Sbjct: 314 ISDASAAEGDRSSTPSDINSPRHRTHSLCNGDSPGPVQKNLHNPIVQSLEDLEDQKRKKK 373
Query: 380 KEKMGFGSISRVFARGKQRKSLDPGLFD 407
KEKMGFGSISRVFARGKQRKSLDPGLFD
Sbjct: 374 KEKMGFGSISRVFARGKQRKSLDPGLFD 401
>gi|65301128 kazrin isoform C [Homo sapiens]
Length = 327
Score = 613 bits (1582), Expect = e-175
Identities = 313/313 (100%), Positives = 313/313 (100%)
Query: 95 MKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTD 154
MKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTD
Sbjct: 1 MKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTD 60
Query: 155 LVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKE 214
LVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKE
Sbjct: 61 LVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKE 120
Query: 215 ATDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPKRHSLAMPGETVLNGNQEW 274
ATDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPKRHSLAMPGETVLNGNQEW
Sbjct: 121 ATDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPKRHSLAMPGETVLNGNQEW 180
Query: 275 VVQADLPLTAAIRQSQQTLYHSHPPHPADRQAVRVSPCHSRQPSVISDASAAEGDRSSTP 334
VVQADLPLTAAIRQSQQTLYHSHPPHPADRQAVRVSPCHSRQPSVISDASAAEGDRSSTP
Sbjct: 181 VVQADLPLTAAIRQSQQTLYHSHPPHPADRQAVRVSPCHSRQPSVISDASAAEGDRSSTP 240
Query: 335 SDINSPRHRTHSLCNGDSPGPVQKNLHNPIVQSLEDLEDQKRKKKKEKMGFGSISRVFAR 394
SDINSPRHRTHSLCNGDSPGPVQKNLHNPIVQSLEDLEDQKRKKKKEKMGFGSISRVFAR
Sbjct: 241 SDINSPRHRTHSLCNGDSPGPVQKNLHNPIVQSLEDLEDQKRKKKKEKMGFGSISRVFAR 300
Query: 395 GKQRKSLDPGLFD 407
GKQRKSLDPGLFD
Sbjct: 301 GKQRKSLDPGLFD 313
>gi|63999741 kazrin isoform C [Homo sapiens]
Length = 327
Score = 613 bits (1582), Expect = e-175
Identities = 313/313 (100%), Positives = 313/313 (100%)
Query: 95 MKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTD 154
MKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTD
Sbjct: 1 MKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTD 60
Query: 155 LVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKE 214
LVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKE
Sbjct: 61 LVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKE 120
Query: 215 ATDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPKRHSLAMPGETVLNGNQEW 274
ATDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPKRHSLAMPGETVLNGNQEW
Sbjct: 121 ATDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPKRHSLAMPGETVLNGNQEW 180
Query: 275 VVQADLPLTAAIRQSQQTLYHSHPPHPADRQAVRVSPCHSRQPSVISDASAAEGDRSSTP 334
VVQADLPLTAAIRQSQQTLYHSHPPHPADRQAVRVSPCHSRQPSVISDASAAEGDRSSTP
Sbjct: 181 VVQADLPLTAAIRQSQQTLYHSHPPHPADRQAVRVSPCHSRQPSVISDASAAEGDRSSTP 240
Query: 335 SDINSPRHRTHSLCNGDSPGPVQKNLHNPIVQSLEDLEDQKRKKKKEKMGFGSISRVFAR 394
SDINSPRHRTHSLCNGDSPGPVQKNLHNPIVQSLEDLEDQKRKKKKEKMGFGSISRVFAR
Sbjct: 241 SDINSPRHRTHSLCNGDSPGPVQKNLHNPIVQSLEDLEDQKRKKKKEKMGFGSISRVFAR 300
Query: 395 GKQRKSLDPGLFD 407
GKQRKSLDPGLFD
Sbjct: 301 GKQRKSLDPGLFD 313
>gi|29171753 PTPRF interacting protein alpha 1 isoform a [Homo
sapiens]
Length = 1185
Score = 202 bits (513), Expect = 1e-51
Identities = 193/678 (28%), Positives = 300/678 (44%), Gaps = 101/678 (14%)
Query: 75 QVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQ---KEQEL 131
Q+ L+E ++ L+++ LLR++ E K LEE+Q K VL+ LR +L + L
Sbjct: 463 QLHLKERMAALEDKNSLLREV-ESAKKQLEETQHDKDQLVLNIEALRAELDHMRLRGASL 521
Query: 132 ARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAV 191
+ L ++ R + TD S L + R LRD E + ++
Sbjct: 522 HHGRPHLGSVPDFRFPMADGHTDSYSTSAVLRRPQKGRLAALRD-----EPSKVQT---- 572
Query: 192 KALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQSLATLT 251
L + WE +QA + A A S D+ D E + + ++ L + +
Sbjct: 573 ---------LNEQDWERAQQASVLANVAQAFESDADVSDG---EDDRDTLLSSVDLLSPS 620
Query: 252 KDVPKRHSLAMPGETVLNG-NQEW-VVQADLPLTAAIRQSQQTLYHSH------------ 297
H+LAM + L+ N+E ++Q + T + ++ S
Sbjct: 621 GQADA-HTLAMMLQEQLDAINKEIRLIQEEKENTEQRAEEIESRVGSGSLDNLGRFRSMS 679
Query: 298 --PPHPADRQAVRVSPCHSRQ-PSVISDASAAEGDR------------------------ 330
PP+PA A P R P I + A E DR
Sbjct: 680 SIPPYPASSLASSSPPGSGRSTPRRIPHSPAREVDRLGVMTLLPPSREEVRDDKTTIKCE 739
Query: 331 SSTPSDINSPR----HR--THSLCNGD------SPGPVQKNLHNPIVQSLEDLEDQKRKK 378
+S PS + R H+ H++ + D S G + NP S +D K
Sbjct: 740 TSPPSSPRALRLDRLHKGALHTVSHEDIRDIRNSTGSQDGPVSNP--SSSNSSQDSLHKA 797
Query: 379 KKEKMGFGSISRVFARGKQRKSLDPGLFDDSDSQCSPTRQS------LSLSEGEEQMDRL 432
K+K SI R+F + ++ + G + S T S LS G+ + +R
Sbjct: 798 PKKKGIKSSIGRLFGKKEKGRPGQTGKEALGQAGVSETDNSSQDALGLSKLGGQAEKNRK 857
Query: 433 QQV--ELVRTT-----PMSHWKAGTVQAWLEVVMAMPM-YVKACTENVKSGKVLLSLSDE 484
Q EL+ P + W TV WLE+ + MP YV AC NVKSG ++ +LSD
Sbjct: 858 LQKKHELLEEARRQGLPFAQWDGPTVVVWLELWVGMPAWYVAACRANVKSGAIMSALSDT 917
Query: 485 DLQLGLGVCSSLHRRKLRLAIEDYRDAEA------GRSLSKAAELDHHWVAKAWLNDIGL 538
++Q +G+ + LHR KLRLAI++ + R+ +++H W+ WL +GL
Sbjct: 918 EIQREIGISNPLHRLKLRLAIQEIMSLTSPSAPPTSRTTLAYGDMNHEWIGNEWLPSLGL 977
Query: 539 SQYSQAFQNHLVDGRMLNSLMKRDLEKHLNVSKKFHQVSILLGIELLYQVNFSREALQER 598
QY F LVD RML+ L K+DL L + FH+ S GI L ++N+ R+ L+ +
Sbjct: 978 PQYRSYFMECLVDARMLDHLTKKDLRGQLKMVDSFHRNSFQCGIMCLRRLNYDRKELERK 1037
Query: 599 RARCETQNIDPVVWTNQRVLKWVRDIDLKEYADNLTNSGVHGAVLVLEPTFNAEAMATAL 658
R +++ D +VW+N RV++W+ I LKEYA+NL SGVHGA+L L+ TF+ A+A L
Sbjct: 1038 REESQSEIKDVLVWSNDRVIRWILSIGLKEYANNLIESGVHGALLALDETFDFSALALLL 1097
Query: 659 GIPSGKHILRRHLAEEMS 676
IP+ R L E +
Sbjct: 1098 QIPTQNTQARAVLEREFN 1115
Score = 41.6 bits (96), Expect = 0.003
Identities = 39/179 (21%), Positives = 80/179 (44%), Gaps = 21/179 (11%)
Query: 86 QEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQAMKADR 145
+E++ + +++E+++K E ++++ +LA + +E L + D
Sbjct: 246 EEDLAKVIELQEIISKQSREQ-----------SQMKERLASLSSHVTELEEDLDTARKDL 294
Query: 146 KRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKES------EDAVKALAKEKD 199
+ + T L +++ A E EE++ + Y ++E+ D ++ KD
Sbjct: 295 IKSEEMNTKLQRDVREAMAQKEDMEERITTLEKRYLAAQREATSVHDLNDKLENEIANKD 354
Query: 200 LLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPKRH 258
+ R+ + RQ +E + A Q K + E+EAELA Q +A L+K +RH
Sbjct: 355 SMHRQTEDKNRQLQERLELAEQKLQQTLRKAETLPEVEAELA---QRVAALSK-AEERH 409
Score = 34.3 bits (77), Expect = 0.45
Identities = 36/137 (26%), Positives = 64/137 (46%), Gaps = 16/137 (11%)
Query: 65 TNMENPQLGAQVLLREEVSRLQEEVHLLRQMKEMLAKDLE--------ESQGGKSSEVLS 116
T +N QL ++ L E+ +LQ+ + + E+ A+ + E + G E L
Sbjct: 360 TEDKNRQLQERLELAEQ--KLQQTLRKAETLPEVEAELAQRVAALSKAEERHGNIEERLR 417
Query: 117 ATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQM-QQLYATLESREEQLRD 175
++ QL +K QEL RA++ + + KRL L+S+ ++L L+ R L D
Sbjct: 418 --QMEAQLEEKNQELQRARQREKMNEEHNKRLSDTVDKLLSESNERLQLHLKERMAALED 475
Query: 176 ---FIRNYEQHRKESED 189
+R E +K+ E+
Sbjct: 476 KNSLLREVESAKKQLEE 492
Score = 30.4 bits (67), Expect = 6.5
Identities = 20/87 (22%), Positives = 41/87 (47%), Gaps = 1/87 (1%)
Query: 154 DLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLERE-KWELRRQA 212
D S +QL ++ ++L D +R ++ ++ + + E+D L+R+ L ++
Sbjct: 31 DADSHFEQLMVSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQEF 90
Query: 213 KEATDHATALRSQLDLKDNRMKELEAE 239
T R QL ++ + EL+AE
Sbjct: 91 AALTKELNVCREQLLEREEEIAELKAE 117
>gi|4505983 PTPRF interacting protein alpha 1 isoform b [Homo sapiens]
Length = 1202
Score = 202 bits (513), Expect = 1e-51
Identities = 193/678 (28%), Positives = 300/678 (44%), Gaps = 101/678 (14%)
Query: 75 QVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQ---KEQEL 131
Q+ L+E ++ L+++ LLR++ E K LEE+Q K VL+ LR +L + L
Sbjct: 463 QLHLKERMAALEDKNSLLREV-ESAKKQLEETQHDKDQLVLNIEALRAELDHMRLRGASL 521
Query: 132 ARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAV 191
+ L ++ R + TD S L + R LRD E + ++
Sbjct: 522 HHGRPHLGSVPDFRFPMADGHTDSYSTSAVLRRPQKGRLAALRD-----EPSKVQT---- 572
Query: 192 KALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQSLATLT 251
L + WE +QA + A A S D+ D E + + ++ L + +
Sbjct: 573 ---------LNEQDWERAQQASVLANVAQAFESDADVSDG---EDDRDTLLSSVDLLSPS 620
Query: 252 KDVPKRHSLAMPGETVLNG-NQEW-VVQADLPLTAAIRQSQQTLYHSH------------ 297
H+LAM + L+ N+E ++Q + T + ++ S
Sbjct: 621 GQADA-HTLAMMLQEQLDAINKEIRLIQEEKENTEQRAEEIESRVGSGSLDNLGRFRSMS 679
Query: 298 --PPHPADRQAVRVSPCHSRQ-PSVISDASAAEGDR------------------------ 330
PP+PA A P R P I + A E DR
Sbjct: 680 SIPPYPASSLASSSPPGSGRSTPRRIPHSPAREVDRLGVMTLLPPSREEVRDDKTTIKCE 739
Query: 331 SSTPSDINSPR----HR--THSLCNGD------SPGPVQKNLHNPIVQSLEDLEDQKRKK 378
+S PS + R H+ H++ + D S G + NP S +D K
Sbjct: 740 TSPPSSPRALRLDRLHKGALHTVSHEDIRDIRNSTGSQDGPVSNP--SSSNSSQDSLHKA 797
Query: 379 KKEKMGFGSISRVFARGKQRKSLDPGLFDDSDSQCSPTRQS------LSLSEGEEQMDRL 432
K+K SI R+F + ++ + G + S T S LS G+ + +R
Sbjct: 798 PKKKGIKSSIGRLFGKKEKGRPGQTGKEALGQAGVSETDNSSQDALGLSKLGGQAEKNRK 857
Query: 433 QQV--ELVRTT-----PMSHWKAGTVQAWLEVVMAMPM-YVKACTENVKSGKVLLSLSDE 484
Q EL+ P + W TV WLE+ + MP YV AC NVKSG ++ +LSD
Sbjct: 858 LQKKHELLEEARRQGLPFAQWDGPTVVVWLELWVGMPAWYVAACRANVKSGAIMSALSDT 917
Query: 485 DLQLGLGVCSSLHRRKLRLAIEDYRDAEA------GRSLSKAAELDHHWVAKAWLNDIGL 538
++Q +G+ + LHR KLRLAI++ + R+ +++H W+ WL +GL
Sbjct: 918 EIQREIGISNPLHRLKLRLAIQEIMSLTSPSAPPTSRTTLAYGDMNHEWIGNEWLPSLGL 977
Query: 539 SQYSQAFQNHLVDGRMLNSLMKRDLEKHLNVSKKFHQVSILLGIELLYQVNFSREALQER 598
QY F LVD RML+ L K+DL L + FH+ S GI L ++N+ R+ L+ +
Sbjct: 978 PQYRSYFMECLVDARMLDHLTKKDLRGQLKMVDSFHRNSFQCGIMCLRRLNYDRKELERK 1037
Query: 599 RARCETQNIDPVVWTNQRVLKWVRDIDLKEYADNLTNSGVHGAVLVLEPTFNAEAMATAL 658
R +++ D +VW+N RV++W+ I LKEYA+NL SGVHGA+L L+ TF+ A+A L
Sbjct: 1038 REESQSEIKDVLVWSNDRVIRWILSIGLKEYANNLIESGVHGALLALDETFDFSALALLL 1097
Query: 659 GIPSGKHILRRHLAEEMS 676
IP+ R L E +
Sbjct: 1098 QIPTQNTQARAVLEREFN 1115
Score = 41.6 bits (96), Expect = 0.003
Identities = 39/179 (21%), Positives = 80/179 (44%), Gaps = 21/179 (11%)
Query: 86 QEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQAMKADR 145
+E++ + +++E+++K E ++++ +LA + +E L + D
Sbjct: 246 EEDLAKVIELQEIISKQSREQ-----------SQMKERLASLSSHVTELEEDLDTARKDL 294
Query: 146 KRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKES------EDAVKALAKEKD 199
+ + T L +++ A E EE++ + Y ++E+ D ++ KD
Sbjct: 295 IKSEEMNTKLQRDVREAMAQKEDMEERITTLEKRYLAAQREATSVHDLNDKLENEIANKD 354
Query: 200 LLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPKRH 258
+ R+ + RQ +E + A Q K + E+EAELA Q +A L+K +RH
Sbjct: 355 SMHRQTEDKNRQLQERLELAEQKLQQTLRKAETLPEVEAELA---QRVAALSK-AEERH 409
Score = 34.3 bits (77), Expect = 0.45
Identities = 36/137 (26%), Positives = 64/137 (46%), Gaps = 16/137 (11%)
Query: 65 TNMENPQLGAQVLLREEVSRLQEEVHLLRQMKEMLAKDLE--------ESQGGKSSEVLS 116
T +N QL ++ L E+ +LQ+ + + E+ A+ + E + G E L
Sbjct: 360 TEDKNRQLQERLELAEQ--KLQQTLRKAETLPEVEAELAQRVAALSKAEERHGNIEERLR 417
Query: 117 ATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQM-QQLYATLESREEQLRD 175
++ QL +K QEL RA++ + + KRL L+S+ ++L L+ R L D
Sbjct: 418 --QMEAQLEEKNQELQRARQREKMNEEHNKRLSDTVDKLLSESNERLQLHLKERMAALED 475
Query: 176 ---FIRNYEQHRKESED 189
+R E +K+ E+
Sbjct: 476 KNSLLREVESAKKQLEE 492
Score = 30.4 bits (67), Expect = 6.5
Identities = 20/87 (22%), Positives = 41/87 (47%), Gaps = 1/87 (1%)
Query: 154 DLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLERE-KWELRRQA 212
D S +QL ++ ++L D +R ++ ++ + + E+D L+R+ L ++
Sbjct: 31 DADSHFEQLMVSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQEF 90
Query: 213 KEATDHATALRSQLDLKDNRMKELEAE 239
T R QL ++ + EL+AE
Sbjct: 91 AALTKELNVCREQLLEREEEIAELKAE 117
>gi|32189362 PTPRF interacting protein alpha 3 [Homo sapiens]
Length = 1194
Score = 186 bits (471), Expect = 9e-47
Identities = 131/415 (31%), Positives = 200/415 (48%), Gaps = 68/415 (16%)
Query: 322 DASAAEGDRSSTPSDINSPRHRTHSLCNGDSPGPVQKNLHNPIVQSLED---------LE 372
+A A G+ + P D P R+ L +Q SLED
Sbjct: 699 EAGAPRGEGPAIPGDTPPPTPRSARLERMTQALALQAG-------SLEDGGPPRGSEGTP 751
Query: 373 DQKRKKKKEKMGFGSISRVFARGKQRKSLDPGLFDDSDSQCSPTRQSLSLSE-------- 424
D K K+K SI R+F + ++ + PG D S +P+ ++L+
Sbjct: 752 DSLHKAPKKKSIKSSIGRLFGKKEKGRMGPPGR-DSSSLAGTPSDETLATDPLGLAKLTG 810
Query: 425 -GEEQMDRLQQVELVRTT-----PMSHWKAGTVQAWLEVVMAMPM-YVKACTENVKSGKV 477
G++ ++ EL+ P + W TV +WLE+ + MP YV AC NVKSG +
Sbjct: 811 PGDKDRRNKRKHELLEEACRQGLPFAAWDGPTVVSWLELWVGMPAWYVAACRANVKSGAI 870
Query: 478 LLSLSDEDLQLGLGVCSSLHRRKLRLAIED-----------------------YRDAEAG 514
+ +LSD ++Q +G+ + LHR KLRLAI++ + + E+
Sbjct: 871 MANLSDTEIQREIGISNPLHRLKLRLAIQEMVSLTSPSAPASSRTSTGNVWMTHEEMESL 930
Query: 515 RSLSKA-------------AELDHHWVAKAWLNDIGLSQYSQAFQNHLVDGRMLNSLMKR 561
+ +K +++H WV WL +GL QY F LVD RML+ L K+
Sbjct: 931 TATTKPETKEISWEQILAYGDMNHEWVGNDWLPSLGLPQYRSYFMESLVDARMLDHLNKK 990
Query: 562 DLEKHLNVSKKFHQVSILLGIELLYQVNFSREALQERRARCETQNIDPVVWTNQRVLKWV 621
+L L + FH+VS+ GI L ++N+ R+ L+ RR +TQ D +VW+N+RV+ WV
Sbjct: 991 ELRGQLKMVDSFHRVSLHYGIMCLKRLNYDRKDLERRREESQTQIRDVMVWSNERVMGWV 1050
Query: 622 RDIDLKEYADNLTNSGVHGAVLVLEPTFNAEAMATALGIPSGKHILRRHLAEEMS 676
+ LKE+A NLT SGVHGA+L L+ TF+ +A L IP+ R+ L +E S
Sbjct: 1051 SGLGLKEFATNLTESGVHGALLALDETFDYSDLALLLQIPTQNAQARQLLEKEFS 1105
Score = 31.2 bits (69), Expect = 3.8
Identities = 20/83 (24%), Positives = 42/83 (50%), Gaps = 1/83 (1%)
Query: 158 QMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLERE-KWELRRQAKEAT 216
++++L T+ + E+L + +R + ++ ++ L EKD L+R+ L ++ T
Sbjct: 27 ELERLMVTMLTERERLLETLREAQDGLATAQLRLRELGHEKDSLQRQLSIALPQEFAALT 86
Query: 217 DHATALRSQLDLKDNRMKELEAE 239
R QL ++ + EL+AE
Sbjct: 87 KELNLCREQLLEREEEIAELKAE 109
>gi|55769554 protein tyrosine phosphatase, receptor type, f
polypeptide (PTPRF), interacting protein (liprin), alpha
4 [Homo sapiens]
Length = 701
Score = 179 bits (453), Expect = 1e-44
Identities = 148/547 (27%), Positives = 243/547 (44%), Gaps = 85/547 (15%)
Query: 188 EDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQ-LDLKDNRMKELEAELAMAKQS 246
++ + A+ +E +++ EK +A+E T+ + L+LK R K ++ S
Sbjct: 93 QEQLDAINEEIRMIQEEKESTELRAEEIETRVTSGSMEALNLKQLR-KRGSIPTSLTALS 151
Query: 247 LATLTKDVPKRHSLAMPGETVLNGNQEWVVQADLPLTAAIRQSQQTLYH--SHPPHPADR 304
LA+ + + R + P T + Q+ + L + +R+ ++ L S + D+
Sbjct: 152 LASASPPLSGRST---PKLTSRSAAQDLDRMGVMTLPSDLRKHRRKLLSPVSREENREDK 208
Query: 305 QAVRVSPCHSRQPSVI------------SDASAAEGDRSSTPSDINSPRHRTHSLCNGDS 352
++ P + + +A D+ S PS NS + H
Sbjct: 209 ATIKCETSPPSSPRTLRLEKLGHPALSQEEGKSALEDQGSNPSSSNSSQDSLHK------ 262
Query: 353 PGPVQKNLHNPIVQSLEDLEDQKRKKKKEKMGFGSISRVFARGKQRKSLDPGLFDDSDSQ 412
G +K + + I + KKEK +SR A G L DS+
Sbjct: 263 -GAKRKGIKSSIGRLFG---------KKEKGRLIQLSRDGATGHV-------LLTDSEFS 305
Query: 413 CSPTRQSLSLSEGEEQMDRLQQVELV------RTTPMSHWKAGTVQAWLEVVMAMPM-YV 465
L E+ RL++ + + P + W TV +WLE+ + MP YV
Sbjct: 306 MQEPMVPAKLGTQAEKDRRLKKKHQLLEDARRKGMPFAQWDGPTVVSWLELWVGMPAWYV 365
Query: 466 KACTENVKSGKVLLSLSDEDLQLGLGVCSSLHRRKLRLAIEDY----------------- 508
AC NVKSG ++ +LSD ++Q +G+ ++LHR KLRLAI++
Sbjct: 366 AACRANVKSGAIMSALSDTEIQREIGISNALHRLKLRLAIQEMVSLTSPSAPPTSRTSSG 425
Query: 509 -----------------RDAEAGRSLSKAA--ELDHHWVAKAWLNDIGLSQYSQAFQNHL 549
D+E G A +++H W+ WL +GL QY F L
Sbjct: 426 NVWVTHEEMETLETSTKTDSEEGSWAQTLAYGDMNHEWIGNEWLPSLGLPQYRSYFMECL 485
Query: 550 VDGRMLNSLMKRDLEKHLNVSKKFHQVSILLGIELLYQVNFSREALQERRARCETQNIDP 609
VD RML+ L K+DL HL + FH+ S+ GI L ++N+ R+ L++RR + + D
Sbjct: 486 VDARMLDHLTKKDLRVHLKMVDSFHRTSLQYGIMCLKRLNYDRKELEKRREESQHEIKDV 545
Query: 610 VVWTNQRVLKWVRDIDLKEYADNLTNSGVHGAVLVLEPTFNAEAMATALGIPSGKHILRR 669
+VWTN +V+ WV+ I L++YA NL SGVHGA+L L+ F+ +A L IP+ R+
Sbjct: 546 LVWTNDQVVHWVQSIGLRDYAGNLHESGVHGALLALDENFDHNTLALILQIPTQNTQARQ 605
Query: 670 HLAEEMS 676
+ E +
Sbjct: 606 VMEREFN 612
>gi|29171755 PTPRF interacting protein alpha 2 [Homo sapiens]
Length = 1257
Score = 177 bits (450), Expect = 3e-44
Identities = 181/705 (25%), Positives = 302/705 (42%), Gaps = 120/705 (17%)
Query: 75 QVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARA 134
Q+ L+E ++ L+E+ ++L Q E K+LEES K +LR +L Q +
Sbjct: 481 QLHLKERMAALEEK-NVLIQESETFRKNLEESLHDKERLAEEIEKLRSELDQLKMRTGSL 539
Query: 135 KEALQAM-----KADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESED 189
E A+ + G D SQ + R + R +R E K D
Sbjct: 540 IEPTIPRTHLDTSAELRYSVGSLVD--SQSDYRTTKVIRRPRRGRMGVRRDEPKVKSLGD 597
Query: 190 AVKALAKEKDLLEREKWELRRQAKEATD--HATALRSQLDLKDNRMKELEAELAMAKQSL 247
++ +L +E + + D T S L + + + M ++ L
Sbjct: 598 HEWNRTQQIGVLSSHPFESDTEMSDIDDDDRETIFSSMDLLSPSGHSDAQTLAMMLQEQL 657
Query: 248 ATLTKDV----PKRHSLAMPGETV--------LNGNQEWVVQADLPLTAAIRQSQQTLYH 295
+ K++ ++ S + E + L G V +TA++ S +L
Sbjct: 658 DAINKEIRLIQEEKESTELRAEEIENRVASVSLEGLNLARVHPGTSITASVTAS--SLAS 715
Query: 296 SHPPH-----------PA---DRQAVRVSPC----HSRQPSVISDASAAEGDRSSTPSDI 337
S PP PA DR V P H R+ +V+ + D+++ +
Sbjct: 716 SSPPSGHSTPKLTPRSPAREMDRMGVMTLPSDLRKHRRKIAVVEEDGRE--DKATIKCET 773
Query: 338 NSPR-----HRTHSLCNGDSPGPVQKNLHNPIVQSLE----------DLEDQKRKKKKEK 382
+ P TH+L P + + + SLE +D K K+K
Sbjct: 774 SPPPTPRALRMTHTL-----PSSYHNDARSSLSVSLEPESLGLGSANSSQDSLHKAPKKK 828
Query: 383 MGFGSISRVFARGKQRKSLDPGLFDDSDSQCSPTRQSLSLSEGEEQMDRLQQV----ELV 438
SI R+F GK+ K+ L +++ + ++SL L + Q ++ +++ EL+
Sbjct: 829 GIKSSIGRLF--GKKEKARLGQLRGFMETEAA-AQESLGLGKLGTQAEKDRRLKKKHELL 885
Query: 439 RTT-----PMSHWKAGTVQAWLEVVMAMPM-YVKACTENVKSGKVLLSLSDEDLQLGLGV 492
P + W TV AWLE+ + MP YV AC NVKSG ++ +LSD ++Q +G+
Sbjct: 886 EEARRKGLPFAQWDGPTVVAWLELWLGMPAWYVAACRANVKSGAIMSALSDTEIQREIGI 945
Query: 493 CSSLHRRKLRLAIEDY-----------------------------------RDAEAGR-- 515
+ LHR KLRLAI++ +++E G
Sbjct: 946 SNPLHRLKLRLAIQEMVSLTSPSAPPTSRTPSGNVWVTHEEMENLAAPAKTKESEEGSWA 1005
Query: 516 ------SLSKAAELDHHWVAKAWLNDIGLSQYSQAFQNHLVDGRMLNSLMKRDLEKHLNV 569
+++H W+ WL +GL QY F LVD RML+ L K+DL HL +
Sbjct: 1006 QCPVFLQTLAYGDMNHEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTKKDLRVHLKM 1065
Query: 570 SKKFHQVSILLGIELLYQVNFSREALQERRARCETQNIDPVVWTNQRVLKWVRDIDLKEY 629
FH+ S+ GI L ++N+ R+ L+ RR + + D +VW+N RV++W++ I L+EY
Sbjct: 1066 VDSFHRTSLQYGIMCLKRLNYDRKELERRREASQHEIKDVLVWSNDRVIRWIQAIGLREY 1125
Query: 630 ADNLTNSGVHGAVLVLEPTFNAEAMATALGIPSGKHILRRHLAEE 674
A+N+ SGVHG+++ L+ F+ ++A L IP+ R+ L E
Sbjct: 1126 ANNILESGVHGSLIALDENFDYSSLALLLQIPTQNTQARQILERE 1170
Score = 45.4 bits (106), Expect = 2e-04
Identities = 53/227 (23%), Positives = 92/227 (40%), Gaps = 50/227 (22%)
Query: 78 LREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSA-------------------- 117
L EE++ +E+ LR+ + + + S+G SE L
Sbjct: 205 LEEELAAANQEIVALREQNVHIQRKMASSEGSTESEHLEGMEPGQKVHEKRLSNGSIDST 264
Query: 118 ------TELRVQLAQKEQELARAKEALQAMKADRKRLKGE----KTDLVS---------- 157
EL+ L ++ E+A+ KE L A+ + ++ E + DL+
Sbjct: 265 DETSQIVELQELLEKQNYEMAQMKERLAALSSRVGEVEQEAETARKDLIKTEEMNTKYQR 324
Query: 158 QMQQLYATLESREEQLRDFIRNYEQHRKES------EDAVKALAKEKDLLEREKWELRRQ 211
+++ A E EE++ + Y ++ES D ++ K+ + R+ E RQ
Sbjct: 325 DIREAMAQKEDMEERITTLEKRYLSAQRESTSIHDMNDKLENELANKEAILRQMEEKNRQ 384
Query: 212 AKEATDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPKRH 258
+E + A Q K + E+EAELA Q +A LTK +RH
Sbjct: 385 LQERLELAEQKLQQTMRKAETLPEVEAELA---QRIAALTK-AEERH 427
Score = 40.0 bits (92), Expect = 0.008
Identities = 51/243 (20%), Positives = 106/243 (43%), Gaps = 19/243 (7%)
Query: 57 SAAGDSAATNMENPQLGAQVLLREEVSRLQEEVHLLRQMKEMLA-KDLEESQGGKSSEVL 115
SA +S + + N +L ++ +E + R EE + RQ++E L + + Q + +E L
Sbjct: 349 SAQRESTSIHDMNDKLENELANKEAILRQMEEKN--RQLQERLELAEQKLQQTMRKAETL 406
Query: 116 SATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRD 175
E+ +LAQ+ L +A+E ++ + L+G+ + ++Q+ + EE +
Sbjct: 407 P--EVEAELAQRIAALTKAEERHGNIEERMRHLEGQLEEKNQELQRARQREKMNEEHNKR 464
Query: 176 FIRNYEQHRKESEDAVK-------ALAKEKDLLEREKWELRRQAKEATDHATALRSQLDL 228
++ ES + ++ A +EK++L +E R+ +E+ L +++
Sbjct: 465 LSDTVDRLLTESNERLQLHLKERMAALEEKNVLIQESETFRKNLEESLHDKERLAEEIE- 523
Query: 229 KDNRMKELEAELAMAKQSLATLTKDVPKRHSLAMPGETVLNGNQEWVVQADLPLTAAIRQ 288
+L +EL K +L + R L E + Q+D T IR+
Sbjct: 524 ------KLRSELDQLKMRTGSLIEPTIPRTHLDTSAELRYSVGSLVDSQSDYRTTKVIRR 577
Query: 289 SQQ 291
++
Sbjct: 578 PRR 580
>gi|170784854 PTPRF interacting protein, binding protein 2 (liprin
beta 2) [Homo sapiens]
Length = 876
Score = 169 bits (427), Expect = 1e-41
Identities = 174/620 (28%), Positives = 257/620 (41%), Gaps = 70/620 (11%)
Query: 79 REEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEAL 138
+ EV++LQE+V L E L L + S E + Q+ Q L E L
Sbjct: 237 KAEVAQLQEQVALKDAEIERLHSQLSRTAALHS-------ESHTERDQEIQRLKMGMETL 289
Query: 139 QAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAV-KALAKE 197
D+ R E T L++Q +++ + + R + +E E K A
Sbjct: 290 LLANEDKDRRIEELTGLLNQYRKVKEIVMVTQGPSE---RTLSINEEEPEGGFSKWNATN 346
Query: 198 KDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPKR 257
KD E K E+ + T L Q L+ K+L L + D +
Sbjct: 347 KDPEELFKQEMPPRCSSPTVGPPPL-PQKSLETRAQKKLSCSLEDLRSESVDKCMDGNQP 405
Query: 258 HSLAMPGETVLNGNQEWVVQADLP--LTAAIRQSQQTLYHSHPPHPADRQAVRVSPCHSR 315
+ P ++ ++ LP L+ A + PP A S R
Sbjct: 406 FPVLEPKDSPFLAEHKYPT---LPGKLSGATPNGEAA---KSPPTICQPDATGSSLLRLR 459
Query: 316 QPSVISDASAAEGDRSSTPSDINSPRHRTHSLCNGDSPGPVQKNLHNPIVQSLEDLEDQK 375
D +A D SST S G GP +P+ D K
Sbjct: 460 DTESGWDDTAVVNDLSSTSS--------------GTESGP-----QSPLTP------DGK 494
Query: 376 RKKKKEKMGFGSISRVFARGKQRKSLDPGLFDDSDSQCSPTRQSLSLSEGEEQMDRLQQV 435
R K K +G I R++ + D+ R L + G ++ R +
Sbjct: 495 RNPKGIKKFWGKI---------RRTQSGNFYTDTLGMAEFRRGGLRATAGP-RLSRTRDS 544
Query: 436 ELVRT---TPMSHWKAGTVQAWLEVVMAMPMYVKACTENVKSGKVLLSLSDEDLQLGLGV 492
+ ++ P + W V AWLE + YV + V SG LL+ + +D++ LG+
Sbjct: 545 KGQKSDANAPFAQWSTERVCAWLED-FGLAQYVIFARQWVSSGHTLLTATPQDMEKELGI 603
Query: 493 CSSLHRRKLRLAIEDYRDAEAGRSLSKAAELDHHWVAKAWLNDIGLSQYSQAFQNHLVDG 552
LHR+KL LA++ + K+A LDH WV + WL+DIGL QY F VDG
Sbjct: 604 KHPLHRKKLVLAVKAINTKQE----EKSALLDHIWVTR-WLDDIGLPQYKDQFHESRVDG 658
Query: 553 RMLNSLMKRDLEKHLNVSKKFHQVSILLGIELLYQVNFSREALQERRARCETQNIDP--- 609
RML L DL L V+ + H +SI I +L+ F+ L R A + N+ P
Sbjct: 659 RMLQYLTVNDL-LFLKVTSQLHHLSIKCAIHVLHVNKFNPHCLHRRPA--DESNLSPSEV 715
Query: 610 VVWTNQRVLKWVRDIDLKEYADNLTNSGVHGAVLVLEPTFNAEAMATALGIPSGKHILRR 669
V W+N RV++W+R +DL EYA NL SGVHG +++LEP F + +A L IP K +LRR
Sbjct: 716 VQWSNHRVMEWLRSVDLAEYAPNLRGSGVHGGLIILEPRFTGDTLAMLLNIPPQKTLLRR 775
Query: 670 HLAEEMSAVFHPANSTGIRE 689
HL + +A+ P RE
Sbjct: 776 HLTTKFNALIGPEAEQEKRE 795
Score = 54.7 bits (130), Expect = 3e-07
Identities = 124/584 (21%), Positives = 215/584 (36%), Gaps = 66/584 (11%)
Query: 77 LLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKE 136
+L ++V E++ L E L ++ E+LS T L Q E++ K
Sbjct: 127 VLTDQVEAQGEKIRDLEVCLEGHQVKLNAAEEMLQQELLSRTSLETQKLDLMTEVSELKL 186
Query: 137 ALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAK 196
L M+ +++ + EK ++ Q L+ + E+L + YE K ++ V L +
Sbjct: 187 KLVGMEKEQREQE-EKQRKAEELLQELRHLKIKVEELENERNQYEWKLKATKAEVAQLQE 245
Query: 197 EKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAK-------QSLAT 249
+ L + E L Q + ++ D + R+K L +A + L
Sbjct: 246 QVALKDAEIERLHSQLSRTAALHSESHTERDQEIQRLKMGMETLLLANEDKDRRIEELTG 305
Query: 250 LTKDVPKRHSLAM----PGETVLNGNQEWVVQADLPLTAAIRQSQQTLYHSHPPHPADRQ 305
L K + M P E L+ N+E A + ++ PP +
Sbjct: 306 LLNQYRKVKEIVMVTQGPSERTLSINEEEPEGGFSKWNATNKDPEELFKQEMPPRCS--- 362
Query: 306 AVRVSPCHSRQPSVISDASAAEGDRSSTPSDINSPRHRTHSLCNGDSPGPVQKNLHNPIV 365
+ V P Q S+ + A+ S + D+ S +G+ P PV + +P +
Sbjct: 363 SPTVGPPPLPQKSL---ETRAQKKLSCSLEDLRS--ESVDKCMDGNQPFPVLEPKDSPFL 417
Query: 366 QSLEDLEDQKRKKKKEKMGFGSISRVFARGKQRKSLDPGLFDDSDSQCSPTRQSLSLSEG 425
+ K G +S G+ KS P D+ S L L +
Sbjct: 418 -----------AEHKYPTLPGKLSGATPNGEAAKS--PPTICQPDATGS---SLLRLRDT 461
Query: 426 EEQMDRLQQVELVRTTPMSHWKAGTVQAWLEVVMAMPMYVKACTENVKSGKVLLSLSDED 485
E D V + +T S ++G P +K GK+ + S
Sbjct: 462 ESGWDDTAVVNDLSST-SSGTESGPQSPLTPDGKRNPKGIKKFW-----GKIRRTQSGNF 515
Query: 486 LQLGLGVCSSLHRRKLRLA----IEDYRDAEAGRSLSKA--AELDHHWVAKAWLNDIGLS 539
LG+ + R LR + RD++ +S + A A+ V AWL D GL+
Sbjct: 516 YTDTLGM-AEFRRGGLRATAGPRLSRTRDSKGQKSDANAPFAQWSTERVC-AWLEDFGLA 573
Query: 540 QYSQAFQNHLVDGRMLNSLMKRDLEKHLNVSKKFHQVSILLGIELLYQVNFSREALQERR 599
QY + + G L + +D+EK L + H+ ++L ++ + + AL +
Sbjct: 574 QYVIFARQWVSSGHTLLTATPQDMEKELGIKHPLHRKKLVLAVKAINTKQEEKSALLDH- 632
Query: 600 ARCETQNIDPVVWTNQRVLKWVRDIDLKEYADNLTNSGVHGAVL 643
+W V +W+ DI L +Y D S V G +L
Sbjct: 633 -----------IW----VTRWLDDIGLPQYKDQFHESRVDGRML 661
Score = 38.9 bits (89), Expect = 0.018
Identities = 47/216 (21%), Positives = 94/216 (43%), Gaps = 52/216 (24%)
Query: 89 VHLLRQMK---EMLAKDLEESQGGKSSEVLSATELRVQ------LAQKEQELARAKEALQ 139
+HL+ ++ EML +L + + S++ T ++ L+Q A + E Q
Sbjct: 51 LHLIEDLRLALEML--ELPQERAALLSQIPGPTAAYIKEWFEESLSQVNHHSAASNETYQ 108
Query: 140 AMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHR--------------- 184
A RL+G+K L+ Q+ L +E++ E++RD E H+
Sbjct: 109 ERLA---RLEGDKESLILQVSVLTDQVEAQGEKIRDLEVCLEGHQVKLNAAEEMLQQELL 165
Query: 185 --------------KESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKD 230
+ SE +K + EK+ +RE+ E +R+A+E L+ +++ +
Sbjct: 166 SRTSLETQKLDLMTEVSELKLKLVGMEKE--QREQEEKQRKAEELLQELRHLKIKVEELE 223
Query: 231 N-------RMKELEAELAMAKQSLATLTKDVPKRHS 259
N ++K +AE+A ++ +A ++ + HS
Sbjct: 224 NERNQYEWKLKATKAEVAQLQEQVALKDAEIERLHS 259
>gi|29294627 PTPRF interacting protein binding protein 1 isoform 1
[Homo sapiens]
Length = 1005
Score = 158 bits (400), Expect = 2e-38
Identities = 122/355 (34%), Positives = 171/355 (48%), Gaps = 20/355 (5%)
Query: 323 ASAAEGDR---SSTPSDINSPRHRTHSL-CNGDSPGPVQKNLHNPIVQSLEDLEDQKRKK 378
ASA DR +S P+ + + L G S P ++P Q D K+K
Sbjct: 522 ASAPNLDRKRSASAPTLAETEKETAEHLDLAGASSRPKDSQRNSPF-QIPPPSPDSKKKS 580
Query: 379 KKEKMGFGSISRVFARGKQRKSLDPGLFDDSDSQCSPTRQSLSLSEGEEQMDRLQQVELV 438
+ FG + R Q + +P + + + TR + G + L Q
Sbjct: 581 RGIMKLFGKLRR-----SQSTTFNPDDMSEPEFKRGGTRATAGPRLGWSR--DLGQSNSD 633
Query: 439 RTTPMSHWKAGTVQAWLEVVMAMPMYVKACTENVKSGKVLLSLSDEDLQLGLGVCSSLHR 498
P + W V WL + + Y+ + + SG+ LL S +DL+ LG+ SLHR
Sbjct: 634 LDMPFAKWTKEQVCNWL-MEQGLGSYLNSGKHWIASGQTLLQASQQDLEKELGIKHSLHR 692
Query: 499 RKLRLAIEDYRDAEAGRSLSKAAELDHHWVAKAWLNDIGLSQYSQAFQNHLVDGRMLNSL 558
+KL+LA++ E + +LD +WV + WL+DIGL QY F VDGRML+ +
Sbjct: 693 KKLQLALQALGSEEE----TNHGKLDFNWVTR-WLDDIGLPQYKTQFDEGRVDGRMLHYM 747
Query: 559 MKRDLEKHLNVSKKFHQVSILLGIELLYQVNFSREALQERRARCETQNIDPVV-WTNQRV 617
DL L V H +SI I++L NF L+ R + T V WTN RV
Sbjct: 748 TVDDLLS-LKVVSVLHHLSIKRAIQVLRINNFEPNCLRRRPSDENTIAPSEVQKWTNHRV 806
Query: 618 LKWVRDIDLKEYADNLTNSGVHGAVLVLEPTFNAEAMATALGIPSGKHILRRHLA 672
++W+R +DL EYA NL SGVHG ++VLEP FN E MA L IP K +LRRHLA
Sbjct: 807 MEWLRSVDLAEYAPNLRGSGVHGGLMVLEPRFNVETMAQLLNIPPNKTLLRRHLA 861
Score = 37.4 bits (85), Expect = 0.053
Identities = 34/147 (23%), Positives = 67/147 (45%), Gaps = 5/147 (3%)
Query: 89 VHLLRQMKEMLAK-DLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQAMKADRKR 147
+HL+ ++ +L + +E +G + S E V+ Q + + R
Sbjct: 49 LHLVEDLRGLLEMMETDEKEGLRCQIPDSTAETLVEWLQSQMTNGHLPGNGDVYQERLAR 108
Query: 148 LKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKE---KDLLERE 204
L+ +K LV Q+ L +E++ E++RD E+HR++ + L +E + LE +
Sbjct: 109 LENDKESLVLQVSVLTDQVEAQGEKIRDLEFCLEEHREKVNATEEMLQQELLSRTSLETQ 168
Query: 205 KWELRRQAKEATDHATAL-RSQLDLKD 230
K +L + TA+ + +LD +D
Sbjct: 169 KLDLMAEISNLKLKLTAVEKDRLDYED 195
>gi|190341068 forkhead-associated (FHA) phosphopeptide binding
domain 1 [Homo sapiens]
Length = 1412
Score = 63.2 bits (152), Expect = 9e-10
Identities = 55/194 (28%), Positives = 94/194 (48%), Gaps = 25/194 (12%)
Query: 74 AQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELAR 133
A+ L EE R+QE LL Q K+ LAK + + + + E L + RVQ + E+ LAR
Sbjct: 701 AKETLEEERKRMQELESLLAQQKKALAKSITQEK-NRVKEALEEEQTRVQ--ELEERLAR 757
Query: 134 AKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVK- 192
KE L++ A KR E LES + +++D + Q ++ SE +
Sbjct: 758 QKEVLESSIAHEKRKAKE-------------ALESEKRKVQDLENHLTQQKEISESNIAY 804
Query: 193 ALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNR----MKELEAELAMAKQSLA 248
K K+ +E+EK ++ ++ + T + +L+LK+ + +L LAM +++
Sbjct: 805 EKRKAKEAMEKEK----KKVQDLENRLTKQKEELELKEQKEDVLNNKLSDALAMVEETQK 860
Query: 249 TLTKDVPKRHSLAM 262
T + K SLA+
Sbjct: 861 TKATESLKAESLAL 874
Score = 42.0 bits (97), Expect = 0.002
Identities = 48/206 (23%), Positives = 99/206 (48%), Gaps = 22/206 (10%)
Query: 50 PGAAASASAAGDSAATNMENPQLGAQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGG 109
PGA A + + ++ +LL +EVSRL + + + K+++ +L+
Sbjct: 207 PGAVPPAEIYVEEDLAQQDKDEI--ILLLGKEVSRLSD-YEIESKYKDVIIANLQNEVAE 263
Query: 110 KSSEVLSATELRVQLAQKEQELARAKEAL-QAMKADRKRLKGEKTDLVSQMQQLYA---- 164
S +V T R Q E+E+++ + L + + A +K ++ K+ +S +Q+ Y+
Sbjct: 264 LSQKVSETTTSR----QNEKEISQKCQVLDEDIDAKQKEIQSLKSQ-ISALQKGYSKVLC 318
Query: 165 -TLESREEQLRDFIRNYEQHRKESEDAVKALAK--EKDLLEREKWELRRQAKEATDHATA 221
TL R ++ ++N ++ K + +KD+L ++ E +Q KE H
Sbjct: 319 QTLSERNSEITS-LKNEGENLKRDNAITSGMVSSLQKDILAKD--EQVQQLKEEVSH--- 372
Query: 222 LRSQLDLKDNRMKELEAELAMAKQSL 247
L+SQ KD++++ L + ++ K+ L
Sbjct: 373 LKSQNKDKDHQLEALGSRCSVLKEEL 398
Score = 39.7 bits (91), Expect = 0.011
Identities = 55/237 (23%), Positives = 99/237 (41%), Gaps = 45/237 (18%)
Query: 78 LREEVSRLQEEVHLLRQMKEMLAKDL-------EESQGGKSSEVLSATELRVQLAQKEQE 130
L +++ +EE+ L Q +++L L EE+Q K++E L A L ++L + E
Sbjct: 823 LENRLTKQKEELELKEQKEDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNETLAE 882
Query: 131 LARAK-----------------EALQ-AMKADRKRLKGEKTDLVSQMQQLYATLESREEQ 172
L K +ALQ ++ R + E + Q++Q T+ S EE+
Sbjct: 883 LETTKTKMIMVEERLILQQKMVKALQDEQESQRHGFEEEIMEYKEQIKQHAQTIVSLEEK 942
Query: 173 LRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNR 232
L + QH K+ E + L K+ D +E + D A ++ KD
Sbjct: 943 L----QKVTQHHKKIEGEIATL-KDNDPAPKE--------ERPQDPLVAPMTESSAKDMA 989
Query: 233 MKELEAELAMAKQSLAT-------LTKDVPKRHSLAMPGETVLNGNQEWVVQADLPL 282
+ L +L A++ + + L KD+ + HS LN Q+ ++ ++ L
Sbjct: 990 YEHLIDDLLAAQKEILSQQEVIMKLRKDLTEAHSRMSDLRGELNEKQKMELEQNVVL 1046
Score = 34.7 bits (78), Expect = 0.35
Identities = 37/125 (29%), Positives = 65/125 (52%), Gaps = 13/125 (10%)
Query: 61 DSAATNMENPQLGAQVLLREE-VSRLQEEV-HLLRQMKEMLAKDLE-ESQGGKSS---EV 114
D+A T+ L +L ++E V +L+EEV HL Q K+ KD + E+ G + S E
Sbjct: 341 DNAITSGMVSSLQKDILAKDEQVQQLKEEVSHLKSQNKD---KDHQLEALGSRCSVLKEE 397
Query: 115 LSATELRVQLAQ-KEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESR---E 170
L + +L + +E+EL K +Q M+ + K+L+ E ++ + TL + E
Sbjct: 398 LKQEDAHRELREAQEKELKLCKTQIQDMEKEMKKLRAELRKSCTEQSVISRTLREKSKVE 457
Query: 171 EQLRD 175
E+L++
Sbjct: 458 EKLQE 462
>gi|45439327 periplakin [Homo sapiens]
Length = 1756
Score = 59.3 bits (142), Expect = 1e-08
Identities = 58/230 (25%), Positives = 106/230 (46%), Gaps = 37/230 (16%)
Query: 80 EEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEA-- 137
+E+ + QE+ ++ + AK EE + E A++ Q+A+KE+EL+R KE
Sbjct: 1293 QEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQ-EEQIARKEEELSRVKERVV 1351
Query: 138 ------------------------------LQAMKADRKRLKGEKTDLVSQMQQLYATLE 167
+ ++A+ +RL+ +T+L Q+++L +
Sbjct: 1352 QQEVVRYEEEPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELERERQ 1411
Query: 168 SREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLD 227
+R E R+ R Q R + + +A A+EK + +K L++ ++A +HA LR QL+
Sbjct: 1412 ARREAEREVQR--LQQRLAALEQEEAEAREK-VTHTQKVVLQQDPQQAREHA-LLRLQLE 1467
Query: 228 LKDNRMKELEAELAMAKQSLATLTKDVPKRHSLAMPGETVLNGNQEWVVQ 277
+ +R + LE EL ++ LA L K K + V G+ E +Q
Sbjct: 1468 EEQHRRQLLEGELETLRRKLAALEKAEVKEKVVLSESVQVEKGDTEQEIQ 1517
Score = 40.8 bits (94), Expect = 0.005
Identities = 50/187 (26%), Positives = 86/187 (45%), Gaps = 22/187 (11%)
Query: 77 LLREEVSRLQEEVHLLRQ----------MKEMLAKDLEESQGGKSSEVLSATE-LRVQLA 125
LL+EE+ LQ ++ L Q +KE+L + + +Q + ++ E LR Q
Sbjct: 966 LLQEELEALQLQLRALEQETRDGGQEYVVKEVLRIEPDRAQADEVLQLREELEALRRQKG 1025
Query: 126 QKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRK 185
+E E+ ++ + A+ ++ R + + T+ Q LE+ +QL++ + +Q R+
Sbjct: 1026 AREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLRE 1085
Query: 186 ESE-------DAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEA 238
+ E D +K L KE+ + E K ++ K D AT R DL R E EA
Sbjct: 1086 KQEEELSFLQDKLKRLEKERAMAE-GKITVKEVLKVEKDAATE-REVSDL--TRQYEDEA 1141
Query: 239 ELAMAKQ 245
A A Q
Sbjct: 1142 AKARASQ 1148
Score = 35.4 bits (80), Expect = 0.20
Identities = 42/192 (21%), Positives = 81/192 (42%), Gaps = 23/192 (11%)
Query: 65 TNMENPQLGAQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQL 124
+ ME + LL E SR QE ++++ A + Q K E L A +LR L
Sbjct: 761 SQMETKLKNQKNLLDEIASREQE-------VQKICANSQQYQQAVKDYE-LEAEKLRSLL 812
Query: 125 AQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHR 184
+ + + + +++ ++K E+ L ++ ++YA R + L +F N + +
Sbjct: 813 DLENGRSSHVSKRAR-LQSPATKVKEEEAALAAKFTEVYAINRQRLQNL-EFALNLLRQQ 870
Query: 185 KESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAK 244
E E + L R + + A +R +LD + R ++LE E+ +
Sbjct: 871 PEVEVTHETLQ-------------RNRPDSGVEEAWKIRKELDEETERRRQLENEVKSTQ 917
Query: 245 QSLATLTKDVPK 256
+ + TL P+
Sbjct: 918 EEIWTLRNQGPQ 929
>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo
sapiens]
Length = 1116
Score = 58.2 bits (139), Expect = 3e-08
Identities = 58/271 (21%), Positives = 114/271 (42%), Gaps = 11/271 (4%)
Query: 3 EDNKQLALRIDGAVQSASQEVTNLRAELTATNRRLAELSGGGGPGPGPGAAASAS-AAGD 61
E+ K+ A + + QE++ EL A +L L+ S A +
Sbjct: 455 EELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKE 514
Query: 62 SAATNMENPQLGAQVLLREEVSRLQEEVHLLRQMKEMLA---------KDLEESQGGKSS 112
A ++ ++ L E+ + L ++ ++ M E KD+ + + K +
Sbjct: 515 QRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVN 574
Query: 113 EVLSATE-LRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREE 171
+ E L+ QL KE++++ KE +++++AD T L + + T+E +E
Sbjct: 575 VLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKE 634
Query: 172 QLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDN 231
Q R ++ + +K L ++ LL+ + E + +HA++L S KD+
Sbjct: 635 QRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDS 694
Query: 232 RMKELEAELAMAKQSLATLTKDVPKRHSLAM 262
R+K LE L K+ + + K H A+
Sbjct: 695 RLKTLEIALEQKKEECLKMESQLKKAHEAAL 725
Score = 47.0 bits (110), Expect = 7e-05
Identities = 62/253 (24%), Positives = 111/253 (43%), Gaps = 39/253 (15%)
Query: 79 REEVSRLQEEVHLLR---QMKEMLAKDLEESQGGKSSEVLSATE----LRVQLAQKEQE- 130
++++ L+E+V LL+ KE DL+E +S L L + L QK++E
Sbjct: 651 KKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEEC 710
Query: 131 ------LARAKEA-------------LQAMKADRKRLKGEKTDLVSQMQQLYATLESREE 171
L +A EA +Q ++ + R K E + +++ +L L+ E
Sbjct: 711 LKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVEN 770
Query: 172 QLRDFIRNYEQHRKESEDAVKALA--KEKDLLEREKW-----ELRRQAKEATDHATALRS 224
+ D + + ++ +D K +A K K+ +E++K E RR+ D + L+
Sbjct: 771 EKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQD 830
Query: 225 QLDLKDNRMKELEAELAMAKQSLA----TLTKDVPKRHSLAMPGETVLNGNQEWVVQADL 280
L KD+R++ELE L + Q A L ++ R + E +L E V Q
Sbjct: 831 SLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMA-MEKVKQELE 889
Query: 281 PLTAAIRQSQQTL 293
+ A + +QQ+L
Sbjct: 890 SMKAKLSSTQQSL 902
Score = 42.0 bits (97), Expect = 0.002
Identities = 46/215 (21%), Positives = 89/215 (41%), Gaps = 29/215 (13%)
Query: 59 AGDSAATNMENPQLGAQVL-LREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSA 117
A ++A +P++ ++ L E++R ++E + + L + L+E + K+ +
Sbjct: 720 AHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKI 779
Query: 118 TELRVQLAQKEQELARAKEALQAMKA-------DRKRLKGEKTDLVSQMQQLYATLESRE 170
EL Q+ + +++A K Q K + +R + D Q+Q + R
Sbjct: 780 AELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRI 839
Query: 171 EQLRDFIRNYEQ------------------HRKESEDAVKALAKEKDLLEREKWELRRQA 212
E+L + +R Q K+ E+ + A+ K K LE K +L
Sbjct: 840 EELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQ 899
Query: 213 KEATDHATALRSQLDLKDNRMKELEAELAMAKQSL 247
+ + T L +L+ R K LE L M +++L
Sbjct: 900 QSLAEKETHL---TNLRAERRKHLEEVLEMKQEAL 931
Score = 38.5 bits (88), Expect = 0.024
Identities = 40/190 (21%), Positives = 88/190 (46%), Gaps = 18/190 (9%)
Query: 82 VSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQ---ELARAKEAL 138
+ LQ+E+ + R + ++ +D G L+ + A+ E+ EL ++ L
Sbjct: 229 IQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTL 288
Query: 139 QAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEK 198
+ M+ + K +++L L+S+ + ++E+ R+ +E + E
Sbjct: 289 EEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLES 348
Query: 199 DLLEREKW------ELRRQAKEATDHAT--ALRSQLDLKDNR-------MKELEAELAMA 243
L ++EK E+ R+ + A D A AL++ +++KD++ +++LE E+ M
Sbjct: 349 LLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQML 408
Query: 244 KQSLATLTKD 253
K + A T++
Sbjct: 409 KSNGALSTEE 418
Score = 38.5 bits (88), Expect = 0.024
Identities = 53/255 (20%), Positives = 110/255 (43%), Gaps = 28/255 (10%)
Query: 74 AQVLLREEVSRLQEEVH-LLRQMKEMLAKD---LEESQGGKSSEVLSATELRVQLAQKEQ 129
AQ+L EE R ++ ++ +Q+++ L K +EE + V E + LAQ+E
Sbjct: 808 AQML--EEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEES 865
Query: 130 ELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKE--- 186
A++ ++ + +++K E + +++ +L +E L + +H +E
Sbjct: 866 ARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLE 925
Query: 187 -SEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQ 245
++A+ A EKD EL K+ + AL+ + KD +++L+ + +
Sbjct: 926 MKQEALLAAISEKD-ANIALLELSSSKKKTQEEVAALKRE---KDRLVQQLKQQTQNRMK 981
Query: 246 SLATLTKDVPKRHSLAMPGETVLNGNQEWVVQADLPLTAAIRQSQQTLYHSHPPHPADRQ 305
+A +D + S + +T + + ++Q L L +S+ LY H
Sbjct: 982 LMADNYEDDHFKSSHS--NQTNHKPSPDQIIQPLLELDQ--NRSKLKLYIGH-------- 1029
Query: 306 AVRVSPCHSRQPSVI 320
+ CH R P ++
Sbjct: 1030 --LTTLCHDRDPLIL 1042
Score = 36.6 bits (83), Expect = 0.091
Identities = 74/385 (19%), Positives = 152/385 (39%), Gaps = 87/385 (22%)
Query: 80 EEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQ-----LAQKEQELARA 134
E + +L E + Q K + AK EE + + L+ E+ V L QKE+E +
Sbjct: 307 ESIKKLLE----MLQSKGLSAKATEEDH--ERTRRLAEAEMHVHHLESLLEQKEKENSML 360
Query: 135 KEALQAM---KADRKRLKGEKT-----------------DLVSQMQQLYA----TLESRE 170
+E + D + K +T DL ++Q L + + E RE
Sbjct: 361 REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEERE 420
Query: 171 EQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKD 230
E+++ + Y H K ++ V+ L +E E + EL+++A ++ +L KD
Sbjct: 421 EEMKQ-MEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKD 479
Query: 231 NRMKELEAELAMAKQSLATLTKDVPKRHSLAMPGETVLNGNQEWVVQADLPLTAAIRQSQ 290
+ L+ +L ++L D K+H + + ++Q ++ + +
Sbjct: 480 TELLALQTKL----ETLTNQFSD-SKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEK 534
Query: 291 QTLYHSHPPHPADRQAVRVSPCHSRQPSVISDASAAEGDRSSTPSDINSPRHRTHSLCNG 350
+T+ +++ I D + +G ++ D+
Sbjct: 535 ETML-------------------NKKTKQIQDMAEEKGTQAGEIHDLKDML--------- 566
Query: 351 DSPGPVQKNLHNPIVQSLEDLEDQKRKKKKEKMGFGSISRVFARGKQR-KSLDPGLFDDS 409
V++ N + + +E+L++Q R K+K+ K+R KSL D +
Sbjct: 567 ----DVKERKVNVLQKKIENLQEQLRDKEKQMSSL----------KERVKSLQA---DTT 609
Query: 410 DSQCSPTRQSLSLSEGEEQMDRLQQ 434
++ + T +L+E E ++RL++
Sbjct: 610 NTDTALTTLEEALAEKERTIERLKE 634
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 58.2 bits (139), Expect = 3e-08
Identities = 47/185 (25%), Positives = 87/185 (47%), Gaps = 15/185 (8%)
Query: 88 EVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQAMKADRKR 147
E L R + ++ E S+ + ++L +LR Q K Q LA ++ ++ K R+R
Sbjct: 349 ESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRR 408
Query: 148 LKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWE 207
L+ ++ +Q RE++ + + E+ RKE E+ +A +EK +ERE+
Sbjct: 409 LEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRA-EEEKRRVEREQEY 467
Query: 208 LRRQAKEATDHATALRSQL-------------DLKDNRMKE-LEAELAMAKQSLATLTKD 253
+RRQ +E H L+ QL +++++R E L+ +L + L +L D
Sbjct: 468 IRRQLEEEQRHLEVLQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHD 527
Query: 254 VPKRH 258
+ H
Sbjct: 528 HRRPH 532
Score = 36.2 bits (82), Expect = 0.12
Identities = 89/382 (23%), Positives = 136/382 (35%), Gaps = 74/382 (19%)
Query: 80 EEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQ 139
EE R +EE + + +E + + LEE Q + EVL L+ Q E +E Q
Sbjct: 449 EERRRAEEEKRRVEREQEYIRRQLEEEQ--RHLEVLQQQLLQEQAMLLECRWREMEEHRQ 506
Query: 140 AMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKD 199
A + R Q+QQ A L S + D R + QH ++
Sbjct: 507 AERLQR------------QLQQEQAYLLSLQ---HDHRRPHPQHSQQPPPP--------- 542
Query: 200 LLEREKWELRRQAKEATDHATALRSQLDLKDN-RMKELEAELAMAKQSLATLTKDVPKRH 258
++E+ + A E H +++D R + A +KQ+ L VP R
Sbjct: 543 --QQERSKPSFHAPEPKAHYEPADRAREVEDRFRKTNHSSPEAQSKQTGRVLEPPVPSR- 599
Query: 259 SLAMPGETVLNGNQEWV---------VQADLPLTAAIRQSQQTLYHSH-----PPHPADR 304
E+ NGN E V Q A+++ + + SH P A
Sbjct: 600 -----SESFSNGNSESVHPALQRPAEPQVQWSHLASLKNNVSPVSRSHSFSDPSPKFAHH 654
Query: 305 QAVRVSPCHSRQPSVISDASAAEGDR--------SSTPSDINSPR------HRTHSLCNG 350
PC + V+S +S ++ + S + SD PR R+ L
Sbjct: 655 HLRSQDPCPPSRSEVLSQSSDSKSEAPDPTQKAWSRSDSDEVPPRVPVRTTSRSPVLSRR 714
Query: 351 DSP--GPVQKNLHNPIVQSLEDLEDQKRKKKKEKM----GFGSISRVFARGKQRKSLDPG 404
DSP G Q+N S +E + ++ EK+ G GS S G PG
Sbjct: 715 DSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSS-----GSSNSGSQPG 769
Query: 405 LFDDSDSQCSPTRQSLSLSEGE 426
S S + S S+ E
Sbjct: 770 SHPGSQSGSGERFRVRSSSKSE 791
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 57.8 bits (138), Expect = 4e-08
Identities = 54/247 (21%), Positives = 106/247 (42%), Gaps = 41/247 (16%)
Query: 23 VTNLRAELTATNRRLAELSGGGGPGPGPGAAASASAAGDSAATNMENPQLGAQVLLREEV 82
+ N ++L AT +L +L A AS+ G S LR+++
Sbjct: 713 IDNFTSQLKATEEKLLDLD----------ALRKASSEGKSEMKK-----------LRQQL 751
Query: 83 SRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRV-QLAQKEQELARAKEAL--- 138
++++ L + K+ E S+ + L EL++ L + E+++ KE L
Sbjct: 752 EAAEKQIKHLE-----IEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKE 806
Query: 139 -QAMKADRKRLKGEKTDLVSQMQQLYATLESREEQ----------LRDFIRNYEQHRKES 187
Q +K E + MQ+ L +EEQ LR+ + + E +E
Sbjct: 807 LQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREK 866
Query: 188 EDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQSL 247
++ + L K K+ LE + E+ + + + + T + +L LK+ ++EL+ +L A ++
Sbjct: 867 DEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENA 926
Query: 248 ATLTKDV 254
+ L K +
Sbjct: 927 SFLQKSI 933
Score = 45.1 bits (105), Expect = 3e-04
Identities = 43/183 (23%), Positives = 84/183 (45%), Gaps = 18/183 (9%)
Query: 81 EVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQA 140
+++++ +E+ L + E L L ++ S S ++ V+ Q +QE A+ E
Sbjct: 897 QLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEE--- 953
Query: 141 MKADRKRLKGEKTDLVSQM-------QQLYATLESREEQLR----DFIRNYEQHRKESED 189
++K L+ + +DL +M Q+L A E + + + ++N ++ ++ED
Sbjct: 954 ---EKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTED 1010
Query: 190 AVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQSLAT 249
+K +E L +E ELR+QA +A TA + + + KE LA + + T
Sbjct: 1011 KLKGAREENSGLLQELEELRKQADKAKAAQTA-EDAMQIMEQMTKEKTETLASLEDTKQT 1069
Query: 250 LTK 252
K
Sbjct: 1070 NAK 1072
Score = 42.7 bits (99), Expect = 0.001
Identities = 42/179 (23%), Positives = 88/179 (49%), Gaps = 18/179 (10%)
Query: 85 LQEEVHLLRQMKE---MLAKDLEESQGGKSSEVLSATELRV-QLAQKEQELARAKEALQA 140
+QE V+ L Q +E ML+ DLE K E L+ E + + ++E++L +AKE L+
Sbjct: 828 MQETVNKLHQKEEQFNMLSSDLE-----KLRENLADMEAKFREKDEREEQLIKAKEKLEN 882
Query: 141 MKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQH----RKESED-AVKALA 195
A+ ++ G+ + +++M E E+L+ + ++ +K ED VKA
Sbjct: 883 DIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQ 942
Query: 196 KEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDV 254
+++ ++ + E + ++ +D L +++ N+ +EL+A A T +++
Sbjct: 943 SQQEAAKKHEEEKKELERKLSD----LEKKMETSHNQCQELKARYERATSETKTKHEEI 997
Score = 39.7 bits (91), Expect = 0.011
Identities = 57/261 (21%), Positives = 111/261 (42%), Gaps = 34/261 (13%)
Query: 1 MMEDNKQLALRIDGAVQSASQEV----TNLRAELTATNRRLAELSGGGGPGPGPGAAASA 56
+ ++N+ L +++ A + S + + L + + + + EL G G A A
Sbjct: 552 LSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFA 611
Query: 57 SAAGDSAATNMENPQLGAQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLS 116
T +E +L Q E+ LQ + +D E + K E L
Sbjct: 612 ELK-----TQIEKMRLDYQ----HEIENLQNQ------------QDSERAAHAKEMEALR 650
Query: 117 ATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDF 176
A ++V + +KE L + L KA+ + L E D ++++Q+ A ++ +E ++
Sbjct: 651 AKLMKV-IKEKENSLEAIRSKLD--KAEDQHLV-EMEDTLNKLQE--AEIKVKELEVLQA 704
Query: 177 IRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKEL 236
N EQ + + A E+ LL+ + LR+ + E LR QL+ + ++K L
Sbjct: 705 KCN-EQTKVIDNFTSQLKATEEKLLDLDA--LRKASSEGKSEMKKLRQQLEAAEKQIKHL 761
Query: 237 EAELAMAKQSLATLTKDVPKR 257
E E +++T+++ R
Sbjct: 762 EIEKNAESSKASSITRELQGR 782
Score = 34.3 bits (77), Expect = 0.45
Identities = 31/140 (22%), Positives = 61/140 (43%)
Query: 118 TELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFI 177
TE + A+K +EAL+ + ++L E+ +++ + + + E++L
Sbjct: 337 TETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALAR 396
Query: 178 RNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELE 237
++QH E E + L + +REK EL Q +E L+ +++ + +LE
Sbjct: 397 DGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLE 456
Query: 238 AELAMAKQSLATLTKDVPKR 257
K + L KD+ R
Sbjct: 457 VATVSEKSRIMELEKDLALR 476
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 57.8 bits (138), Expect = 4e-08
Identities = 54/247 (21%), Positives = 106/247 (42%), Gaps = 41/247 (16%)
Query: 23 VTNLRAELTATNRRLAELSGGGGPGPGPGAAASASAAGDSAATNMENPQLGAQVLLREEV 82
+ N ++L AT +L +L A AS+ G S LR+++
Sbjct: 748 IDNFTSQLKATEEKLLDLD----------ALRKASSEGKSEMKK-----------LRQQL 786
Query: 83 SRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRV-QLAQKEQELARAKEAL--- 138
++++ L + K+ E S+ + L EL++ L + E+++ KE L
Sbjct: 787 EAAEKQIKHLE-----IEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKE 841
Query: 139 -QAMKADRKRLKGEKTDLVSQMQQLYATLESREEQ----------LRDFIRNYEQHRKES 187
Q +K E + MQ+ L +EEQ LR+ + + E +E
Sbjct: 842 LQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREK 901
Query: 188 EDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQSL 247
++ + L K K+ LE + E+ + + + + T + +L LK+ ++EL+ +L A ++
Sbjct: 902 DEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENA 961
Query: 248 ATLTKDV 254
+ L K +
Sbjct: 962 SFLQKSI 968
Score = 45.1 bits (105), Expect = 3e-04
Identities = 43/183 (23%), Positives = 84/183 (45%), Gaps = 18/183 (9%)
Query: 81 EVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQA 140
+++++ +E+ L + E L L ++ S S ++ V+ Q +QE A+ E
Sbjct: 932 QLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEE--- 988
Query: 141 MKADRKRLKGEKTDLVSQM-------QQLYATLESREEQLR----DFIRNYEQHRKESED 189
++K L+ + +DL +M Q+L A E + + + ++N ++ ++ED
Sbjct: 989 ---EKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTED 1045
Query: 190 AVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQSLAT 249
+K +E L +E ELR+QA +A TA + + + KE LA + + T
Sbjct: 1046 KLKGAREENSGLLQELEELRKQADKAKAAQTA-EDAMQIMEQMTKEKTETLASLEDTKQT 1104
Query: 250 LTK 252
K
Sbjct: 1105 NAK 1107
Score = 42.7 bits (99), Expect = 0.001
Identities = 42/179 (23%), Positives = 88/179 (49%), Gaps = 18/179 (10%)
Query: 85 LQEEVHLLRQMKE---MLAKDLEESQGGKSSEVLSATELRV-QLAQKEQELARAKEALQA 140
+QE V+ L Q +E ML+ DLE K E L+ E + + ++E++L +AKE L+
Sbjct: 863 MQETVNKLHQKEEQFNMLSSDLE-----KLRENLADMEAKFREKDEREEQLIKAKEKLEN 917
Query: 141 MKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQH----RKESED-AVKALA 195
A+ ++ G+ + +++M E E+L+ + ++ +K ED VKA
Sbjct: 918 DIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQ 977
Query: 196 KEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDV 254
+++ ++ + E + ++ +D L +++ N+ +EL+A A T +++
Sbjct: 978 SQQEAAKKHEEEKKELERKLSD----LEKKMETSHNQCQELKARYERATSETKTKHEEI 1032
Score = 39.7 bits (91), Expect = 0.011
Identities = 57/261 (21%), Positives = 111/261 (42%), Gaps = 34/261 (13%)
Query: 1 MMEDNKQLALRIDGAVQSASQEV----TNLRAELTATNRRLAELSGGGGPGPGPGAAASA 56
+ ++N+ L +++ A + S + + L + + + + EL G G A A
Sbjct: 587 LSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFA 646
Query: 57 SAAGDSAATNMENPQLGAQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLS 116
T +E +L Q E+ LQ + +D E + K E L
Sbjct: 647 ELK-----TQIEKMRLDYQ----HEIENLQNQ------------QDSERAAHAKEMEALR 685
Query: 117 ATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDF 176
A ++V + +KE L + L KA+ + L E D ++++Q+ A ++ +E ++
Sbjct: 686 AKLMKV-IKEKENSLEAIRSKLD--KAEDQHLV-EMEDTLNKLQE--AEIKVKELEVLQA 739
Query: 177 IRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKEL 236
N EQ + + A E+ LL+ + LR+ + E LR QL+ + ++K L
Sbjct: 740 KCN-EQTKVIDNFTSQLKATEEKLLDLDA--LRKASSEGKSEMKKLRQQLEAAEKQIKHL 796
Query: 237 EAELAMAKQSLATLTKDVPKR 257
E E +++T+++ R
Sbjct: 797 EIEKNAESSKASSITRELQGR 817
Score = 36.6 bits (83), Expect = 0.091
Identities = 31/152 (20%), Positives = 66/152 (43%), Gaps = 6/152 (3%)
Query: 82 VSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQAM 141
+ L++ + + + L ++LE+++ SE EL LA + QE+A + L++
Sbjct: 466 IKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESN 525
Query: 142 K--ADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKD 199
K D ++ S ++L T + ++ ++ + + +KAL +
Sbjct: 526 KPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATE 585
Query: 200 LLERE----KWELRRQAKEATDHATALRSQLD 227
L +E K +L KE +D +S+L+
Sbjct: 586 KLSKENESLKSKLEHANKENSDVIALWKSKLE 617
Score = 32.0 bits (71), Expect = 2.2
Identities = 34/151 (22%), Positives = 63/151 (41%), Gaps = 14/151 (9%)
Query: 118 TELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFI 177
TE + A+K +EAL+ + ++L E+ +++ + + + E++L
Sbjct: 337 TETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALAR 396
Query: 178 RNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALR-------------- 223
++QH E E + L + +REK EL Q +E L+
Sbjct: 397 DGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLE 456
Query: 224 SQLDLKDNRMKELEAELAMAKQSLATLTKDV 254
+Q L+ R+KELE L K L +++
Sbjct: 457 TQTKLEHARIKELEQSLLFEKTKADKLQREL 487
>gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]
Length = 1088
Score = 57.4 bits (137), Expect = 5e-08
Identities = 49/207 (23%), Positives = 91/207 (43%), Gaps = 21/207 (10%)
Query: 77 LLREEVSRLQ---EEVHLLRQMKEMLAKDLEESQGGKSSEV------LSATELRV----- 122
+L+ EV L+ EE + K +D+ E +G ++ E+ L E +V
Sbjct: 491 ILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQK 550
Query: 123 -------QLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRD 175
QL KE++++ KE +++++AD T L + + T+E +EQ
Sbjct: 551 KIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDR 610
Query: 176 FIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKE 235
R ++ + +K L ++ LL+ + E + +HA++L S KD+R+K
Sbjct: 611 DEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKT 670
Query: 236 LEAELAMAKQSLATLTKDVPKRHSLAM 262
LE L K+ + + K H A+
Sbjct: 671 LEIALEQKKEECLKMESQLKKAHEAAL 697
Score = 47.0 bits (110), Expect = 7e-05
Identities = 62/253 (24%), Positives = 111/253 (43%), Gaps = 39/253 (15%)
Query: 79 REEVSRLQEEVHLLR---QMKEMLAKDLEESQGGKSSEVLSATE----LRVQLAQKEQE- 130
++++ L+E+V LL+ KE DL+E +S L L + L QK++E
Sbjct: 623 KKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEEC 682
Query: 131 ------LARAKEA-------------LQAMKADRKRLKGEKTDLVSQMQQLYATLESREE 171
L +A EA +Q ++ + R K E + +++ +L L+ E
Sbjct: 683 LKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVEN 742
Query: 172 QLRDFIRNYEQHRKESEDAVKALA--KEKDLLEREKW-----ELRRQAKEATDHATALRS 224
+ D + + ++ +D K +A K K+ +E++K E RR+ D + L+
Sbjct: 743 EKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQD 802
Query: 225 QLDLKDNRMKELEAELAMAKQSLA----TLTKDVPKRHSLAMPGETVLNGNQEWVVQADL 280
L KD+R++ELE L + Q A L ++ R + E +L E V Q
Sbjct: 803 SLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMA-MEKVKQELE 861
Query: 281 PLTAAIRQSQQTL 293
+ A + +QQ+L
Sbjct: 862 SMKAKLSSTQQSL 874
Score = 42.0 bits (97), Expect = 0.002
Identities = 46/215 (21%), Positives = 89/215 (41%), Gaps = 29/215 (13%)
Query: 59 AGDSAATNMENPQLGAQVL-LREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSA 117
A ++A +P++ ++ L E++R ++E + + L + L+E + K+ +
Sbjct: 692 AHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKI 751
Query: 118 TELRVQLAQKEQELARAKEALQAMKA-------DRKRLKGEKTDLVSQMQQLYATLESRE 170
EL Q+ + +++A K Q K + +R + D Q+Q + R
Sbjct: 752 AELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRI 811
Query: 171 EQLRDFIRNYEQ------------------HRKESEDAVKALAKEKDLLEREKWELRRQA 212
E+L + +R Q K+ E+ + A+ K K LE K +L
Sbjct: 812 EELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQ 871
Query: 213 KEATDHATALRSQLDLKDNRMKELEAELAMAKQSL 247
+ + T L +L+ R K LE L M +++L
Sbjct: 872 QSLAEKETHL---TNLRAERRKHLEEVLEMKQEAL 903
Score = 38.5 bits (88), Expect = 0.024
Identities = 40/190 (21%), Positives = 88/190 (46%), Gaps = 18/190 (9%)
Query: 82 VSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQ---ELARAKEAL 138
+ LQ+E+ + R + ++ +D G L+ + A+ E+ EL ++ L
Sbjct: 229 IQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTL 288
Query: 139 QAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEK 198
+ M+ + K +++L L+S+ + ++E+ R+ +E + E
Sbjct: 289 EEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLES 348
Query: 199 DLLEREKW------ELRRQAKEATDHAT--ALRSQLDLKDNR-------MKELEAELAMA 243
L ++EK E+ R+ + A D A AL++ +++KD++ +++LE E+ M
Sbjct: 349 LLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQML 408
Query: 244 KQSLATLTKD 253
K + A T++
Sbjct: 409 KSNGALSTEE 418
Score = 38.5 bits (88), Expect = 0.024
Identities = 53/255 (20%), Positives = 110/255 (43%), Gaps = 28/255 (10%)
Query: 74 AQVLLREEVSRLQEEVH-LLRQMKEMLAKD---LEESQGGKSSEVLSATELRVQLAQKEQ 129
AQ+L EE R ++ ++ +Q+++ L K +EE + V E + LAQ+E
Sbjct: 780 AQML--EEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEES 837
Query: 130 ELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKE--- 186
A++ ++ + +++K E + +++ +L +E L + +H +E
Sbjct: 838 ARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLE 897
Query: 187 -SEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQ 245
++A+ A EKD EL K+ + AL+ + KD +++L+ + +
Sbjct: 898 MKQEALLAAISEKD-ANIALLELSSSKKKTQEEVAALKRE---KDRLVQQLKQQTQNRMK 953
Query: 246 SLATLTKDVPKRHSLAMPGETVLNGNQEWVVQADLPLTAAIRQSQQTLYHSHPPHPADRQ 305
+A +D + S + +T + + ++Q L L +S+ LY H
Sbjct: 954 LMADNYEDDHFKSSHS--NQTNHKPSPDQIIQPLLELDQ--NRSKLKLYIGH-------- 1001
Query: 306 AVRVSPCHSRQPSVI 320
+ CH R P ++
Sbjct: 1002 --LTTLCHDRDPLIL 1014
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 57.0 bits (136), Expect = 7e-08
Identities = 39/139 (28%), Positives = 69/139 (49%), Gaps = 1/139 (0%)
Query: 88 EVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQAMKADRKR 147
E L R + ++ E S+ + ++L +LR Q K Q LA ++ ++ K R+R
Sbjct: 349 ESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRR 408
Query: 148 LKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWE 207
L+ ++ +Q RE++ + + E+ RKE E+ +A +EK +ERE+
Sbjct: 409 LEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRA-EEEKRRVEREQEY 467
Query: 208 LRRQAKEATDHATALRSQL 226
+RRQ +E H L+ QL
Sbjct: 468 IRRQLEEEQRHLEVLQQQL 486
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 57.0 bits (136), Expect = 7e-08
Identities = 39/139 (28%), Positives = 69/139 (49%), Gaps = 1/139 (0%)
Query: 88 EVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQAMKADRKR 147
E L R + ++ E S+ + ++L +LR Q K Q LA ++ ++ K R+R
Sbjct: 349 ESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRR 408
Query: 148 LKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWE 207
L+ ++ +Q RE++ + + E+ RKE E+ +A +EK +ERE+
Sbjct: 409 LEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRA-EEEKRRVEREQEY 467
Query: 208 LRRQAKEATDHATALRSQL 226
+RRQ +E H L+ QL
Sbjct: 468 IRRQLEEEQRHLEVLQQQL 486
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 56.2 bits (134), Expect = 1e-07
Identities = 59/218 (27%), Positives = 95/218 (43%), Gaps = 22/218 (10%)
Query: 54 ASASAAGDSAATNMENPQLGAQVLLREEVSRLQEEVH----LLRQMKEMLAKDLEESQGG 109
A+ A AAT + QL + R+E RL E+H L + +LA +LEE +
Sbjct: 1681 ATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRA- 1739
Query: 110 KSSEVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESR 169
L E +LA EQEL A E L + + L +K L + + QL +E
Sbjct: 1740 ----ALEQGERSRRLA--EQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEA 1793
Query: 170 EEQLRDFIRNYE----------QHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHA 219
++ R+ + + K+ +D L + K LE+ EL+ + +EA A
Sbjct: 1794 AQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQARLEEAEQAA 1853
Query: 220 -TALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPK 256
+ Q+ + +++ELEAEL ++ A K V K
Sbjct: 1854 LRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRK 1891
Score = 52.0 bits (123), Expect = 2e-06
Identities = 118/549 (21%), Positives = 207/549 (37%), Gaps = 85/549 (15%)
Query: 2 MEDNKQLALRIDGAVQSASQEVTNLRAELTATNRRLAELSGGGGPGPGPGAAASASAAGD 61
++D K + + Q+ +V NL E+ A + +A L+ A A GD
Sbjct: 1003 IDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLT----KEKKALQEAHQQALGD 1058
Query: 62 -SAATNMENPQLGAQVLLREEVSRLQ---EEVHLLR----QMKEMLAKDLEESQGGKSSE 113
A + + A++ L ++V L+ E+ LR + K L DL+ +Q +
Sbjct: 1059 LQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADA 1118
Query: 114 VLSATELRVQLAQKEQELARAKEALQ-------AMKADRKRLKGEKTDLVSQMQQLYATL 166
+L +L +K+ EL++ ++ M+ K L+ +L +++ A
Sbjct: 1119 AQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAAR 1178
Query: 167 ESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQL 226
E+Q + R E+ + E+A A A +++ + + EL R +E + ALR +
Sbjct: 1179 ARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEE--AALRHEA 1236
Query: 227 DLKDNRMKELE--AELAMAKQSLATLTKDVPKRHSLAMPGETVLNGNQEWVVQADLPLTA 284
+ R K+ E AEL SL + + + K S L N E + +A
Sbjct: 1237 TVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEK 1296
Query: 285 AIRQSQQTLYHSHPPHPADRQAVRVSPCHSRQPSVISDASAAEGDRSSTPSDINSPRHRT 344
R + L ++V + ++DAS G + +++
Sbjct: 1297 LCRTYEDQL---------SEAKIKVEELQRQ----LADASTQRGRLQTESGELSRLLEEK 1343
Query: 345 HSLCNGDSPGPVQKNLHNPIVQSLEDLEDQKRKKKKEKMGFGSISRVFARGKQRKSLDPG 404
L + S G QSLE+L Q ++ K K A Q D
Sbjct: 1344 ECLISQLSRGKAL------AAQSLEELRRQLEEESKAK-------SALAHAVQALRHDCD 1390
Query: 405 LFDDSDSQCSPTRQSLSLSEGEEQMDRLQQVELVRTTPMSHWK----AGTVQAWLEVVMA 460
L + + E E Q + LQ++ ++ W+ A +Q
Sbjct: 1391 LLREQHEE-----------EAEAQAE-LQRLLSKANAEVAQWRSKYEADAIQR------- 1431
Query: 461 MPMYVKACTENVKSGKVLLSL----SDEDLQLGLGVCSSLHRRKLRLAIE-DYRDAEAGR 515
TE ++ K L+L ++E ++ CSSL + KLRL E + E R
Sbjct: 1432 --------TEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELER 1483
Query: 516 SLSKAAELD 524
+ S AA LD
Sbjct: 1484 ATSAAAALD 1492
Score = 49.3 bits (116), Expect = 1e-05
Identities = 45/161 (27%), Positives = 70/161 (43%), Gaps = 17/161 (10%)
Query: 110 KSSEVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKG-------EKTDLVSQMQQL 162
K +L + + +LA EL + AL A +A R+ L+ EK DL Q+Q
Sbjct: 884 KMKPLLRSAQAEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAE 943
Query: 163 YATLESREEQLRDFIRNYEQ---------HRKESEDAVKA-LAKEKDLLEREKWELRRQA 212
L EE+ I++ Q R E E+ V A LA + LE E EL++
Sbjct: 944 QDNLADAEERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDI 1003
Query: 213 KEATDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKD 253
+ + +N++K L E+A +S+A LTK+
Sbjct: 1004 DDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKE 1044
Score = 45.4 bits (106), Expect = 2e-04
Identities = 45/165 (27%), Positives = 82/165 (49%), Gaps = 11/165 (6%)
Query: 81 EVSRLQEE----VHLLRQMKEMLAKDLEE--SQGGKSSEVLSATELRVQLAQKEQELARA 134
E+SRL EE + L + K + A+ LEE Q + S+ SA VQ + + +L R
Sbjct: 1335 ELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLRE 1394
Query: 135 KEALQA-MKADRKRLKGEKTDLVSQMQQLY-ATLESREEQLRDFIRNYEQHRKESEDAVK 192
+ +A +A+ +RL + V+Q + Y A R E+L + + +E+E+ V+
Sbjct: 1395 QHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVE 1454
Query: 193 ALAKEKDLLEREKWELRRQAKEAT---DHATALRSQLDLKDNRMK 234
A + LE+ K L+ ++++ T + AT+ + LD K ++
Sbjct: 1455 AANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLE 1499
Score = 42.0 bits (97), Expect = 0.002
Identities = 38/163 (23%), Positives = 74/163 (45%), Gaps = 11/163 (6%)
Query: 92 LRQMKEMLAKDLEESQGGKSS-----EVLSATELRVQLAQKEQ--ELARAKEALQAMKAD 144
L + K+ LA L+E++ G + L +LR+Q ++ EL RA A A+
Sbjct: 1435 LEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKK 1494
Query: 145 RKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLERE 204
++ L+ + Q +++ LE+ + + R + R E+A++AL + L+RE
Sbjct: 1495 QRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEAL----ETLKRE 1550
Query: 205 KWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQSL 247
L+ + + TD + + + K LE E + + +L
Sbjct: 1551 NKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAAL 1593
Score = 40.8 bits (94), Expect = 0.005
Identities = 64/234 (27%), Positives = 102/234 (43%), Gaps = 73/234 (31%)
Query: 78 LREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATE-------------LRVQL 124
L+EE+S L ++V L + + L K + +G KS E+ +A E LR+QL
Sbjct: 1554 LQEEISDLTDQVSLSGKSIQELEKTKKALEGEKS-EIQAALEEAEGALELEETKTLRIQL 1612
Query: 125 -------------AQKEQELA-------RAKEALQA-MKAD----------RKRLKGEKT 153
A+K++E A RA E+LQA + A+ +K+++G+
Sbjct: 1613 ELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLN 1672
Query: 154 DLVSQMQQLYATLESREEQLRDFI-----------RNYEQH-RKESEDAVKALAKEKDLL 201
DL ++Q +AT ++ E Q + R+ EQ E + +AL + LL
Sbjct: 1673 DL--ELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLL 1730
Query: 202 EREKWELR--------------RQAKEATDHATALRSQLDLKDNRMKELEAELA 241
E ELR ++ EAT+ L SQ N+ K+LEA+LA
Sbjct: 1731 AAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLA 1784
Score = 39.3 bits (90), Expect = 0.014
Identities = 44/185 (23%), Positives = 79/185 (42%), Gaps = 38/185 (20%)
Query: 74 AQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELAR 133
A L ++ L+ + R+ +E + ++LE +Q + S L R++ +E
Sbjct: 1487 AAAALDKKQRHLERALEERRRQEEEMQRELEAAQ--RESRGLGTELFRLRHGHEE----- 1539
Query: 134 AKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKA 193
A EAL+ +K + K L+ E +DL Q+ S +++
Sbjct: 1540 ALEALETLKRENKNLQEEISDLTDQVSL-------------------------SGKSIQE 1574
Query: 194 LAKEKDLLEREKWELRRQAKEA-----TDHATALRSQLDLKDNRMKELEAELAMAKQSLA 248
L K K LE EK E++ +EA + LR QL+L + E++ +LA + A
Sbjct: 1575 LEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVK-AEVDRKLAEKDEECA 1633
Query: 249 TLTKD 253
L ++
Sbjct: 1634 NLRRN 1638
Score = 37.4 bits (85), Expect = 0.053
Identities = 58/260 (22%), Positives = 114/260 (43%), Gaps = 34/260 (13%)
Query: 3 EDNKQLALRIDGA---VQSASQEVTNL-RAEL---TATNRRLAELSGGGGPGPGPGAAAS 55
E K+LALR+ A V++A+ + ++L +A+L T + EL A S
Sbjct: 1437 EAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELE----------RATS 1486
Query: 56 ASAAGDSAATNMENPQLGAQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVL 115
A+AA D ++E A R + +Q E+ ++ L +L + G E L
Sbjct: 1487 AAAALDKKQRHLER----ALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHE-EAL 1541
Query: 116 SATE--------LRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLE 167
A E L+ +++ +++ + +++Q ++ +K L+GEK+++ + +++ LE
Sbjct: 1542 EALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALE 1601
Query: 168 SREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQ-L 226
E + Q + E + + +E L R + + D T R++ L
Sbjct: 1602 LEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEAL 1661
Query: 227 DLK---DNRMKELEAELAMA 243
LK + + +LE +L A
Sbjct: 1662 RLKKKMEGDLNDLELQLGHA 1681
Score = 35.8 bits (81), Expect = 0.16
Identities = 32/161 (19%), Positives = 72/161 (44%), Gaps = 13/161 (8%)
Query: 77 LLREEVSRLQEEVHLLRQMKEMLAKDLEESQ------------GGKSSEVLSATELRVQL 124
++ EE+ + Q+ L +MK+ L + + E Q GGK ++R
Sbjct: 1813 MMAEELKKEQDTSAHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELE 1872
Query: 125 AQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHR 184
A+ + E + EAL+ ++ +R+K E + ++ A ++ ++L+ +++Y++
Sbjct: 1873 AELDAEQKKHAEALKGVRKHERRVK-ELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQF 1931
Query: 185 KESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQ 225
+E+E + + E + +A A A LR++
Sbjct: 1932 EEAEQQANTNLAKYRKAQHELDDAEERADMAETQANKLRAR 1972
Score = 31.2 bits (69), Expect = 3.8
Identities = 43/182 (23%), Positives = 75/182 (41%), Gaps = 18/182 (9%)
Query: 83 SRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQAMK 142
S L V LR ++L + EE E + EL+ L++ E+A+ + +A
Sbjct: 1376 SALAHAVQALRHDCDLLREQHEE-------EAEAQAELQRLLSKANAEVAQWRSKYEADA 1428
Query: 143 ADR-KRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESED----------AV 191
R + L+ K L ++Q+ +E+ + + + + ESED A
Sbjct: 1429 IQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAA 1488
Query: 192 KALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQSLATLT 251
AL K++ LER E RRQ +E A + + + L A ++L TL
Sbjct: 1489 AALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLK 1548
Query: 252 KD 253
++
Sbjct: 1549 RE 1550
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 55.8 bits (133), Expect = 1e-07
Identities = 49/187 (26%), Positives = 86/187 (45%), Gaps = 16/187 (8%)
Query: 77 LLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKE 136
L REE R +E+ R+ E + DL + +++ EL++QLA+KE+EL A
Sbjct: 1036 LRREEKQR--QELEKTRRKLEGDSTDLSDQIAELQAQI---AELKMQLAKKEEELQAALA 1090
Query: 137 ALQAMKADRKRLKGEKTDLVSQMQQLYATLESR-------EEQLRDFIRNYEQHRKESED 189
++ A + + +L SQ+ +L LES E+Q RD E + E ED
Sbjct: 1091 RVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELED 1150
Query: 190 AVKALAKEKDLLEREKWEL----RRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQ 245
+ + A +++L + + E+ + +EA H ++ ++EL +L K+
Sbjct: 1151 TLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKR 1210
Query: 246 SLATLTK 252
A L K
Sbjct: 1211 VKANLEK 1217
Score = 51.6 bits (122), Expect = 3e-06
Identities = 41/195 (21%), Positives = 83/195 (42%), Gaps = 4/195 (2%)
Query: 75 QVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARA 134
Q++L ++ +L +E LL +L E + S + + E+ L R
Sbjct: 980 QIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRRE 1039
Query: 135 KEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKAL 194
++ Q ++ R++L+G+ TDL Q+ +L A + + QL E+ + + V+
Sbjct: 1040 EKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQL----AKKEEELQAALARVEEE 1095
Query: 195 AKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDV 254
A +K++ ++ EL Q E + + R+ + + + ++L EL K L
Sbjct: 1096 AAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDST 1155
Query: 255 PKRHSLAMPGETVLN 269
+ L E +N
Sbjct: 1156 AAQQELRSKREQEVN 1170
Score = 45.4 bits (106), Expect = 2e-04
Identities = 40/172 (23%), Positives = 81/172 (47%), Gaps = 8/172 (4%)
Query: 66 NMENPQLGAQVLLREEVSRLQEEVH--LLRQMKEMLAKDLEESQGG-KSSEVLSATELRV 122
N++ Q+ + L ++ E L RQ KE+ K L+E +G KS S T L
Sbjct: 1756 NLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVK-LQEMEGTVKSKYKASITALEA 1814
Query: 123 QLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQ 182
++AQ E++L + QA +R + + D++ Q+ E ++Q +Q
Sbjct: 1815 KIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQ 1874
Query: 183 HRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMK 234
+++ E+A +E + +L+R+ ++AT+ A A+ ++ N+++
Sbjct: 1875 LKRQLEEA----EEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLR 1922
Score = 43.9 bits (102), Expect = 6e-04
Identities = 38/174 (21%), Positives = 80/174 (45%), Gaps = 25/174 (14%)
Query: 80 EEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQ 139
EE+ +EE+ +R+ K++ A++ TE+ +Q E + +E LQ
Sbjct: 845 EEMMAKEEELVKVRE-KQLAAEN-------------RLTEMETLQSQLMAEKLQLQEQLQ 890
Query: 140 AMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKD 199
A +T+L ++ ++L A L +++++L + + E +E E+ + L EK
Sbjct: 891 A-----------ETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKK 939
Query: 200 LLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKD 253
+++ EL Q +E L+ + + ++K+LE E + + L K+
Sbjct: 940 KMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKE 993
Score = 42.4 bits (98), Expect = 0.002
Identities = 51/208 (24%), Positives = 83/208 (39%), Gaps = 22/208 (10%)
Query: 59 AGDSAATNMENPQLGAQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSAT 118
A + + QL A+ L E + LQ ++ M E L L+E ++ A
Sbjct: 849 AKEEELVKVREKQLAAENRLTE-METLQSQL-----MAEKL--QLQEQLQAETELCAEAE 900
Query: 119 ELRVQLAQKEQELARAKEALQAMKADRKR----LKGEKTDLVSQMQQLYATLESREEQLR 174
ELR +L K+QEL L+A + + L+ EK + +Q+L LE E +
Sbjct: 901 ELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQ 960
Query: 175 DF----------IRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRS 224
++ E+ + ED LAKEK LLE E E + + +L
Sbjct: 961 KLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAK 1020
Query: 225 QLDLKDNRMKELEAELAMAKQSLATLTK 252
+ + + +LE L ++ L K
Sbjct: 1021 LKNKHEAMITDLEERLRREEKQRQELEK 1048
Score = 41.2 bits (95), Expect = 0.004
Identities = 41/198 (20%), Positives = 84/198 (42%), Gaps = 38/198 (19%)
Query: 78 LREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLA---QKEQELARA 134
L ++++ LQ ++ ++K LAK EE Q + A + + L + E +++
Sbjct: 1060 LSDQIAELQAQI---AELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISEL 1116
Query: 135 KEALQAMKADRKRLKGEKTDLVSQMQQLYATLESR------------------------- 169
+E L++ +A R + + +K DL +++ L LE
Sbjct: 1117 QEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTL 1176
Query: 170 EEQLRDFIRNYEQHRKESEDAVKALAKE-------KDLLEREKWELRRQAKEATDHATAL 222
EE+ + ++ R++ AV+ LA++ K LE+ K L + E + L
Sbjct: 1177 EEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVL 1236
Query: 223 RSQLDLKDNRMKELEAEL 240
+++ K++EA+L
Sbjct: 1237 LQGKGDSEHKRKKVEAQL 1254
Score = 40.0 bits (92), Expect = 0.008
Identities = 51/256 (19%), Positives = 105/256 (41%), Gaps = 41/256 (16%)
Query: 76 VLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELA--- 132
+ L+EE++ + +Q ++ LA ++ S G + + L ++AQ E+EL
Sbjct: 1683 IQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQ 1742
Query: 133 --------RAKEA-----------------LQAMKADRKRLKGEKTDLVSQMQQLYATLE 167
R K+A Q + R++L+ + +L ++Q++ T++
Sbjct: 1743 GNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVK 1802
Query: 168 SR--------EEQLRDFIRNYEQHRKESEDAVKAL----AKEKDLLEREKWELRRQAKEA 215
S+ E ++ + KE + A K + K KD+L + E RR A++
Sbjct: 1803 SKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDE-RRNAEQY 1861
Query: 216 TDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPKRHSLAMPGETVLNGNQEWV 275
D A ++L +++E E E A S L +++ A ++ + +
Sbjct: 1862 KDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKL 1921
Query: 276 VQADLPLTAAIRQSQQ 291
+ DLP R +++
Sbjct: 1922 RRGDLPFVVPRRMARK 1937
Score = 38.1 bits (87), Expect = 0.031
Identities = 58/268 (21%), Positives = 112/268 (41%), Gaps = 42/268 (15%)
Query: 11 RIDGAVQSASQEVTNLRAELTATNRRLAELSGGGGPGPGPGAAASASAAGDSAATNMENP 70
+++G S ++ L+A++ +LA+ AA A ++A NM
Sbjct: 1052 KLEGDSTDLSDQIAELQAQIAELKMQLAKKEE-------ELQAALARVEEEAAQKNMALK 1104
Query: 71 QLGAQVLLREEVSRLQEEVHLLRQMK--------------EMLAKDLEESQGGKSS--EV 114
++ L ++S LQE++ R + E L +LE++ ++ E+
Sbjct: 1105 KIRE---LESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQEL 1161
Query: 115 LSATELRVQLAQKE-QELARAKEA-LQAMKADRKRLKGEKTDLVSQMQQLYA-------T 165
S E V + +K +E A+ EA +Q M+ + E + + Q +++ A T
Sbjct: 1162 RSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQT 1221
Query: 166 LESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQ 225
LE+ +L + ++ Q + +SE K + + L+ + E R E D T L+ +
Sbjct: 1222 LENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVE 1281
Query: 226 LDLKDNRMKELEAELAMAKQSLATLTKD 253
LD + L+ + + LTKD
Sbjct: 1282 LD-------NVTGLLSQSDSKSSKLTKD 1302
Score = 36.2 bits (82), Expect = 0.12
Identities = 45/191 (23%), Positives = 81/191 (42%), Gaps = 28/191 (14%)
Query: 81 EVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQA 140
E ++L+ EV+L + MK +DL QG +L Q+ + E EL ++
Sbjct: 1552 EDAKLRLEVNL-QAMKAQFERDL---QGRDEQSEEKKKQLVRQVREMEAELEDERKQRSM 1607
Query: 141 MKADRKRLKGEKTDL--------------VSQMQQLYATLESREEQLRDFIRNYEQ---H 183
A RK+L+ + DL + Q+++L A ++ +L D + E+
Sbjct: 1608 AVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQ 1667
Query: 184 RKESEDAVKA-------LAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKEL 236
KE+E +K+ L +E ER K + +++ E D + L + L
Sbjct: 1668 AKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRL 1727
Query: 237 EAELAMAKQSL 247
EA +A ++ L
Sbjct: 1728 EARIAQLEEEL 1738
Score = 34.7 bits (78), Expect = 0.35
Identities = 43/194 (22%), Positives = 86/194 (44%), Gaps = 12/194 (6%)
Query: 78 LREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKE-QELARAKE 136
L ++V++LQ E L + +L++ +S+ K ++ SA E ++Q Q+ QE R K
Sbjct: 1271 LADKVTKLQVE---LDNVTGLLSQS--DSKSSKLTKDFSALESQLQDTQELLQEENRQKL 1325
Query: 137 ALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAK 196
+L K+++ EK Q+++ + E+Q+ +K+ ED+V L
Sbjct: 1326 SLSTKL---KQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLET 1382
Query: 197 EKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELE---AELAMAKQSLATLTKD 253
+++ + + +L ++ + A K +EL+ +L +QS L K
Sbjct: 1383 AEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKK 1442
Query: 254 VPKRHSLAMPGETV 267
K L +T+
Sbjct: 1443 QKKFDQLLAEEKTI 1456
Score = 32.7 bits (73), Expect = 1.3
Identities = 37/197 (18%), Positives = 84/197 (42%), Gaps = 23/197 (11%)
Query: 80 EEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQ 139
EE++ E+ ++ E + LE +G ++EV + + K +++ + LQ
Sbjct: 1199 EELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQ 1258
Query: 140 AMKADRKRLKGEKTDLVSQMQ---------------------QLYATLESREEQLRDFIR 178
+ +R++ E D V+++Q + ++ LES+ + ++ ++
Sbjct: 1259 VKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQ 1318
Query: 179 NYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATA-LRSQLDLKDNRMKELE 237
+ + +K + EK+ RE+ E +AK + A L +Q+ +M++
Sbjct: 1319 EENRQKLSLSTKLKQVEDEKNSF-REQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSV 1377
Query: 238 AELAMAKQSLATLTKDV 254
L A++ L KD+
Sbjct: 1378 GCLETAEEVKRKLQKDL 1394
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 55.8 bits (133), Expect = 1e-07
Identities = 47/161 (29%), Positives = 73/161 (45%), Gaps = 17/161 (10%)
Query: 110 KSSEVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKG-------EKTDLVSQMQQL 162
K +L + E ++A ++E R KEAL+ +A RK L+ EK DL Q+Q
Sbjct: 835 KIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAE 894
Query: 163 YATLESREEQLRDFIRNYEQ---------HRKESEDAVKA-LAKEKDLLEREKWELRRQA 212
L EE+ I+N Q R E E+ + A L +K LE E EL+R
Sbjct: 895 QDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDI 954
Query: 213 KEATDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKD 253
+ + + +N++K L E+A + +A LTK+
Sbjct: 955 DDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKE 995
Score = 44.3 bits (103), Expect = 4e-04
Identities = 49/179 (27%), Positives = 81/179 (45%), Gaps = 27/179 (15%)
Query: 85 LQEEVHLLRQMK-EMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQAMKA 143
+Q E++ R+ + + + +DLEE+ +A LR + A EL + LQ +K
Sbjct: 1159 VQIEMNKKREAEFQKMRRDLEEAT---LQHEATAAALRKKHADSVAELGEQIDNLQRVKQ 1215
Query: 144 ----DRKRLKGEKTDLVSQMQQLY---ATLESREEQLRDFIRNYEQHRKESEDAVKALAK 196
++ K E D+ S M+Q+ A LE L D + + +E++ +V L
Sbjct: 1216 KLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTS 1275
Query: 197 EKDLLEREKWELRRQAKEATDHATALRSQL------------DLKDNRMKELEAELAMA 243
++ L+ E EL RQ D AL SQL DLK +E++A+ A+A
Sbjct: 1276 QRAKLQTENGELSRQ----LDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALA 1330
Score = 43.9 bits (102), Expect = 6e-04
Identities = 47/183 (25%), Positives = 84/183 (45%), Gaps = 11/183 (6%)
Query: 63 AATNMENPQLGAQVLLREE-VSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELR 121
A EN +L Q+ +E +S+L Q E L + LEE K+ A
Sbjct: 1278 AKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKN-----ALAHA 1332
Query: 122 VQLAQKEQELARAK-EALQAMKADRKRLKGEKTDLVSQMQQLYAT-LESREEQLRDFIRN 179
+Q A+ + +L R + E KA+ +R+ + V+Q + Y T R E+L + +
Sbjct: 1333 LQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKK 1392
Query: 180 YEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEA---TDHATALRSQLDLKDNRMKEL 236
Q +E+E+AV+A+ + LE+ K L+ + ++ + + A + LD K ++
Sbjct: 1393 LAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKI 1452
Query: 237 EAE 239
AE
Sbjct: 1453 LAE 1455
Score = 40.8 bits (94), Expect = 0.005
Identities = 36/157 (22%), Positives = 65/157 (41%), Gaps = 8/157 (5%)
Query: 104 EESQGGKSSEVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLY 163
EESQ S A L +L + + + E L+ K + K L+ E +DL Q+
Sbjct: 1461 EESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSG 1520
Query: 164 ATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWEL--------RRQAKEA 215
T+ E+ + + + E+A +L E+ + R + E R+ A++
Sbjct: 1521 KTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKD 1580
Query: 216 TDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTK 252
+ A R+ L + D+ L+AE ++L K
Sbjct: 1581 EEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKK 1617
Score = 40.0 bits (92), Expect = 0.008
Identities = 45/198 (22%), Positives = 89/198 (44%), Gaps = 38/198 (19%)
Query: 77 LLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSAT-------ELRVQLAQKEQ 129
LLRE+ +EE +++ +L+K E ++ A E + +LAQ+ Q
Sbjct: 1342 LLREQY---EEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ 1398
Query: 130 ELARAKEALQA----MKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDF---IRNYEQ 182
E A EA+ A ++ + RL+ E DL+ +++ A + +++ R+F + ++Q
Sbjct: 1399 EAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQ 1458
Query: 183 HRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQ--------LDLKDNR-- 232
+ES+ +++ KE L E ++L+ +E+ +H + + DL +
Sbjct: 1459 KYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGS 1518
Query: 233 -----------MKELEAE 239
K+LEAE
Sbjct: 1519 SGKTIHELEKVRKQLEAE 1536
Score = 35.4 bits (80), Expect = 0.20
Identities = 33/182 (18%), Positives = 76/182 (41%), Gaps = 4/182 (2%)
Query: 67 MENPQLGAQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQ 126
+E + + L + VS LQE+ L Q++ +L +++ + + +L ++ +
Sbjct: 863 LEKSEARRKELEEKMVSLLQEKNDLQLQVQAE-QDNLADAEERCDQLIKNKIQLEAKVKE 921
Query: 127 KEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATL---ESREEQLRDFIRNYEQH 183
+ L +E + A +++L+ E ++L + L TL E + + ++N +
Sbjct: 922 MNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEE 981
Query: 184 RKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMA 243
++ + L KEK L+ + + D L + ++ +LE L
Sbjct: 982 MAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQE 1041
Query: 244 KQ 245
K+
Sbjct: 1042 KK 1043
Score = 35.0 bits (79), Expect = 0.27
Identities = 39/176 (22%), Positives = 74/176 (42%), Gaps = 8/176 (4%)
Query: 71 QLGAQVLLREEVSRLQEEVHL---LRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQK 127
QL A+V +E RL++E + L K L + E + L+ ++ +
Sbjct: 914 QLEAKV--KEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHAT 971
Query: 128 EQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKES 187
E ++ E + + +L EK L QQ L++ E+++ + + ++
Sbjct: 972 ENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQV 1031
Query: 188 EDAVKALAKEKDL---LEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAEL 240
+D +L +EK + LER K +L K + L + D R+K+ + EL
Sbjct: 1032 DDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFEL 1087
Score = 31.6 bits (70), Expect = 2.9
Identities = 29/157 (18%), Positives = 73/157 (46%), Gaps = 4/157 (2%)
Query: 98 MLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKE-ALQAMKADRKRLKGEKTDLV 156
M+A++L++ Q + + + + L A++ AL+ K ++L+ +L
Sbjct: 1764 MMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELE 1823
Query: 157 SQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWEL---RRQAK 213
++++ + +R R ++ ++E+ K L + +DL+++ + ++ +RQA+
Sbjct: 1824 NELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAE 1883
Query: 214 EATDHATALRSQLDLKDNRMKELEAELAMAKQSLATL 250
EA + A S+ + + E E +A+ + L
Sbjct: 1884 EAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKL 1920
>gi|116008447 CAP-GLY domain containing linker protein 2 isoform 1
[Homo sapiens]
Length = 1046
Score = 55.5 bits (132), Expect = 2e-07
Identities = 92/428 (21%), Positives = 169/428 (39%), Gaps = 48/428 (11%)
Query: 106 SQGGKSSEVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEK----------TDL 155
S GG+ S TE + A+K +EAL+ + ++L E+ T
Sbjct: 329 SVGGRPSRSGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSH 388
Query: 156 VSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRR----- 210
+ ++++ A L+++ EQ ++ E+ + + V+++ KEK L + E RR
Sbjct: 389 ICEVEKEIALLKAQHEQ---YVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRKVEDL 445
Query: 211 --QAKEATDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPKRHSLAMPGETVL 268
+ +E + L +Q L+ R+ ELE L + K L +++ TV
Sbjct: 446 QFRVEEESITKGDLETQTQLEHARIGELEQSLLLEKAQAERLLRELADNRL-----TTVA 500
Query: 269 NGNQEWVVQADLPL-TAAIRQSQQTLYHSHPPHPADRQAVRVSPCHSRQPSVISDASAAE 327
++ ++ +L L I + QQ L HS PP P A + R S +
Sbjct: 501 EKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRES 560
Query: 328 GD-RSSTPSDINSPRHRTHSLCNGDSPGPVQKNLHNPIVQSLEDLEDQKRKKKKEKMGFG 386
G R + + + L + + Q + L+D+ ++ E MG
Sbjct: 561 GVLRDKYEKALKAYQAEVDKL----------RAANEKYAQEVAGLKDKVQQATSENMGL- 609
Query: 387 SISRVFARGKQRKSLDPGLFDDSDSQCSPTRQSLSLSEGEEQMDRLQQVELVRTTPMSH- 445
+ LD L D + +L+ G +Q + + ++ M H
Sbjct: 610 -------MDNWKSKLD-SLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQ 661
Query: 446 WKAGTVQAWLEVVMAMPMYVK-ACTENVKSGKVLLSLSDEDLQLGLGVCSSLHRRKLRLA 504
+ G +QA ++ AM + K A E ++ + L+ + L V +S HR +L+ A
Sbjct: 662 LELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEVQASQHRLELQEA 721
Query: 505 IEDYRDAE 512
+ RDAE
Sbjct: 722 QDQRRDAE 729
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 55.5 bits (132), Expect = 2e-07
Identities = 65/338 (19%), Positives = 138/338 (40%), Gaps = 35/338 (10%)
Query: 1 MMEDNKQLALRI-------DGAVQSASQEVTNLRAELTATNRRLAELSGGGGPGPGPGAA 53
+ ED +Q+A ++ +++ Q + AE R+AE+S
Sbjct: 2346 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS-----------R 2394
Query: 54 ASASAAGDSAATNMENPQLGAQV----LLREEVSRLQEEVHLLRQMKEMLAKDLEES--Q 107
A A A D+ + ++G ++ L +E L + + + RQ + A+ L E+ +
Sbjct: 2395 AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2454
Query: 108 GGKSSEVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLE 167
+ E L +QL +E + + ++ LQ +A ++ EK L+ + + +
Sbjct: 2455 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2514
Query: 168 SREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLD 227
E+ +D + +Q R+E + + + +E+ L E RR+ EA + + +L
Sbjct: 2515 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2574
Query: 228 LKDNRMKELEAELAMAKQSLATLTKDVPKRHSLAMPGETVLNGNQEWVVQADLPLTAAIR 287
+ + ++ E LA Q L + + ++H A+ + E V + + T +
Sbjct: 2575 QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL-------AHSEEVTASQVAATKTLP 2627
Query: 288 QSQQTL----YHSHPPHPADRQAVRVSPCHSRQPSVIS 321
+ L + P H D +VS ++ ++S
Sbjct: 2628 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS 2665
Score = 46.2 bits (108), Expect = 1e-04
Identities = 62/252 (24%), Positives = 105/252 (41%), Gaps = 34/252 (13%)
Query: 11 RIDGAVQSASQEVTNLRAELTATNRRLAELSGGGGPGPGPGAAASASAAGDSAATNMENP 70
R+ +A+Q+ L AEL + L A+ A A +S +T+ ++
Sbjct: 1738 RLQREAAAATQKRQELEAELAKVRAEMEVL-----------LASKARAEEESRSTSEKSK 1786
Query: 71 Q-----LGAQVLLREEVSRLQ---EEVHLLRQMKEMLAKDLEESQGGKSSEVLSA----- 117
Q G L EE +RL+ EE RQ+ E A +E L+A
Sbjct: 1787 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1846
Query: 118 ---TELRVQLAQKEQELARAKEALQAMKADRKRLKGE----KTDLVSQMQQLYATLESRE 170
TE + L +KE E R + + R+RL+ + K D+ ++ QL +S
Sbjct: 1847 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1906
Query: 171 EQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHA-TALRS--QLD 227
E+ + + + + R++ E+ + AL + K EL + +A LRS Q +
Sbjct: 1907 ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 1966
Query: 228 LKDNRMKELEAE 239
L+ R ++L AE
Sbjct: 1967 LEAARQRQLAAE 1978
Score = 45.8 bits (107), Expect = 2e-04
Identities = 57/226 (25%), Positives = 99/226 (43%), Gaps = 30/226 (13%)
Query: 52 AAASASAAGDSAATNMENPQLGAQVLLREEVS--------RLQEEVHLLRQMKEM-LAKD 102
A A A A + A ++ ++ +V+ REE + +QEE+ LRQ E +
Sbjct: 1378 AHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1436
Query: 103 LEESQGGKSSEVLSATELRV---QLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQM 159
+++ + S + E+RV QL E++ A+ LQA++A + + +K +
Sbjct: 1437 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA 1496
Query: 160 QQLYATLESREEQLRDFIRNYEQHRKESEDAVKA---LAKEKDLLEREKWELRRQAKEA- 215
++L Q++D + Q E VKA A+EK + ELR QA+EA
Sbjct: 1497 ERL-------RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1549
Query: 216 -----TDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPK 256
+ A + Q+ L + + EAEL + S A T + +
Sbjct: 1550 RRLRQAEVERARQVQVAL-ETAQRSAEAELQSKRASFAEKTAQLER 1594
Score = 42.4 bits (98), Expect = 0.002
Identities = 64/263 (24%), Positives = 110/263 (41%), Gaps = 35/263 (13%)
Query: 21 QEVTNLRAELTATNRRLAELSGGGGPGPGPGAAASASAAGDSAATNMENPQLGAQVLLRE 80
+E+ +R +L AT R+ GG G A A A E + + + E
Sbjct: 1452 EEIRVVRLQLEATERQR-----GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1506
Query: 81 EVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVL--SATELRVQLAQKEQELARAKE-A 137
+ Q EV L ++K E+ + ++ E L A E +L Q E E AR + A
Sbjct: 1507 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1566
Query: 138 LQ-AMKADRKRLKGEKTDLVSQMQQLYATLESRE---EQLRDFIRNYEQHRKESEDAVKA 193
L+ A ++ L+ ++ + QL +L+ QLR+ E R+ + A
Sbjct: 1567 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE-----EAERRAQQQAEAE 1621
Query: 194 LAKEKDLLEREKWE--------LRRQAKEATDHATALRSQLDLKDNRMKELEA------- 238
A+E+ E E+W+ LR QA+E + +++ + K E EA
Sbjct: 1622 RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE-KQKEEAEREARRRGKAE 1680
Query: 239 ELAMAKQSLATLTKDVPKRHSLA 261
E A+ ++ LA +++ K+ LA
Sbjct: 1681 EQAVRQRELA--EQELEKQRQLA 1701
Score = 41.6 bits (96), Expect = 0.003
Identities = 55/216 (25%), Positives = 99/216 (45%), Gaps = 21/216 (9%)
Query: 54 ASASAAGDSAATNMENPQLGAQVLLR-----EEVSRLQEEVHLLRQMKEMLAKDLEESQG 108
A A A + A +E QL A LR EEV++ Q+ + K+ + E +
Sbjct: 1618 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQ-QKSLAQAEAEKQKEEAEREARRR 1676
Query: 109 GKSSE-VLSATELRVQLAQKEQELARAKEALQAMKADRK--RLKGEKTDLVSQMQQLYAT 165
GK+ E + EL Q +K+++LA A Q + A+++ RL+ E T+ Q +QL
Sbjct: 1677 GKAEEQAVRQRELAEQELEKQRQLAEGT-AQQRLAAEQELIRLRAE-TEQGEQQRQL--- 1731
Query: 166 LESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQ 225
LE +L+ Q R+E E + + E ++L K +++ ++ + + +
Sbjct: 1732 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS---KQR 1788
Query: 226 LDLKDNRMKELEAELAMAKQSLATLTKDVPKRHSLA 261
L+ + R +EL E A L L ++ ++ LA
Sbjct: 1789 LEAEAGRFRELAEEAA----RLRALAEEAKRQRQLA 1820
Score = 41.2 bits (95), Expect = 0.004
Identities = 42/163 (25%), Positives = 74/163 (45%), Gaps = 15/163 (9%)
Query: 79 REEVSRLQEEVHLLRQMKEMLAKDLEESQG---GKSSEVLSATE----LRVQLAQKEQ-- 129
RE R + E +RQ +E+ ++LE+ + G + + L+A + LR + Q EQ
Sbjct: 1671 REARRRGKAEEQAVRQ-RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR 1729
Query: 130 -----ELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHR 184
ELAR + A R+ L+ E + ++M+ L A+ EE+ R +Q
Sbjct: 1730 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1789
Query: 185 KESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLD 227
+ + LA+E L E +RQ + A + A R++ +
Sbjct: 1790 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1832
Score = 40.8 bits (94), Expect = 0.005
Identities = 49/186 (26%), Positives = 82/186 (44%), Gaps = 21/186 (11%)
Query: 75 QVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARA 134
Q+ EE R + E R K + A++ Q + E + + +V+ A++ +E A
Sbjct: 1974 QLAAEEERRRREAEE---RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ 2030
Query: 135 KEALQ---AMKADRKRLKGEKTDLVSQMQQ----LYATLESREEQLRDFIRNYEQHRKES 187
+ A Q A +A +KRL+ E+ +QQ L TL+ + L E R+ +
Sbjct: 2031 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2090
Query: 188 EDAVKALAKEKDLLEREKWELRRQAKEA------TDHATALRSQLDLKDNRM-KELEAEL 240
E+A +A + ERE + RRQ +EA + R+Q ++ KE E E
Sbjct: 2091 EEAEEARVQA----EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2146
Query: 241 AMAKQS 246
A Q+
Sbjct: 2147 ARRAQA 2152
Score = 40.8 bits (94), Expect = 0.005
Identities = 38/178 (21%), Positives = 77/178 (43%), Gaps = 5/178 (2%)
Query: 85 LQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQA---M 141
LQEE ++Q+ E A+ +Q L+ +L Q A E+ L +A+Q +
Sbjct: 2266 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2325
Query: 142 KADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLL 201
KA+ + L+ +K Q ++L E +QL + + +++ + ++ E + L
Sbjct: 2326 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2385
Query: 202 EREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPKRHS 259
+ E+ R A + A R Q + ++ ELA ++ T ++ ++ S
Sbjct: 2386 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH--RTELATQEKVTLVQTLEIQRQQS 2441
Score = 39.3 bits (90), Expect = 0.014
Identities = 52/206 (25%), Positives = 87/206 (42%), Gaps = 30/206 (14%)
Query: 52 AAASASAAGDSAATNMENPQLGAQVLLREEVSRLQEEVHLLRQMK------EMLAKDLEE 105
A A A AA + E +E R Q E LRQ + E K E+
Sbjct: 2127 ARAQAQAAAEKLRKEAE----------QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2176
Query: 106 SQGGKSSEVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYAT 165
+ K+ T LR+QL + + + E LQ RLK E T+ Q Q+
Sbjct: 2177 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ-------RLKAEATEAARQRSQVEEE 2229
Query: 166 LESREEQLRDFIRNYEQHRKESEDAVKALAKEKD----LLEREKWELRRQAKEATDHATA 221
L S Q+ + + + R E+E+ L ++KD L+ E ++++ A+EA + A
Sbjct: 2230 LFSVRVQMEELSK--LKARIEAENRALIL-RDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2286
Query: 222 LRSQLDLKDNRMKELEAELAMAKQSL 247
+ L+ ++L + A+A++ L
Sbjct: 2287 AQEAARLRQLAEEDLAQQRALAEKML 2312
Score = 37.0 bits (84), Expect = 0.070
Identities = 51/222 (22%), Positives = 82/222 (36%), Gaps = 33/222 (14%)
Query: 53 AASASAAGDSAATNMENPQLGAQVLLREEVSRL-----QEEVHLLRQMKEMLAKDLEESQ 107
AA AA A E +L A+V EE RL QE L+ +E K L+ +
Sbjct: 1995 AAEEEAARQRKAALEEVERLKAKV---EEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2051
Query: 108 GGKSSEVLSATELRVQLAQKEQELA-----------RAKEALQAMKADRKRLKGEKTDLV 156
+ V + Q Q+EQ + RA E + + +R + V
Sbjct: 2052 KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV 2111
Query: 157 SQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKW---------- 206
+ ++L + E + + E+ RKE+E A+ + R+K
Sbjct: 2112 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2171
Query: 207 ----ELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAK 244
+ RQ + T LR QL+ D++ L+ EL K
Sbjct: 2172 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2213
Score = 33.5 bits (75), Expect = 0.77
Identities = 38/194 (19%), Positives = 77/194 (39%), Gaps = 5/194 (2%)
Query: 53 AASASAAGDSAATNMENPQLGAQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSS 112
A+ AA A +E ++ + E+ R +E+ L + LA + E +
Sbjct: 1932 ASFEKAAAGKAELELELGRIRSNA---EDTLRSKEQAELEAARQRQLAAEEERRRREAEE 1988
Query: 113 EVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQ 172
V + + A++ + E L+A + +RL+ ++ QL + Q
Sbjct: 1989 RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ 2048
Query: 173 LRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNR 232
+ + +KE E + L +E+ +L++ + E A+ A + A R Q + + +
Sbjct: 2049 AEEKAHAFAVQQKEQE-LQQTLQQEQSVLDQLRGE-AEAARRAAEEAEEARVQAEREAAQ 2106
Query: 233 MKELEAELAMAKQS 246
+ E KQS
Sbjct: 2107 SRRQVEEAERLKQS 2120
Score = 30.0 bits (66), Expect = 8.5
Identities = 41/179 (22%), Positives = 82/179 (45%), Gaps = 21/179 (11%)
Query: 74 AQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELAR 133
AQV L+ R + E LR ++++LA +EE+Q + E V L E +L
Sbjct: 504 AQVTLQSVQRRPELEDSTLRYLQDLLAW-VEENQ-----HRVDGAEWGVDLPSVEAQLGS 557
Query: 134 AK---EALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDA 190
+ ++++ +A +R + ++ L + Y R + + N + R S ++
Sbjct: 558 HRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES 617
Query: 191 VKAL--AKEKDLL---EREKWELRRQAKEATDHATA-------LRSQLDLKDNRMKELE 237
+ + A K+L+ E+E+ E+ + + TA L +L+LK+ ++KEL+
Sbjct: 618 LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQ 676
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 55.5 bits (132), Expect = 2e-07
Identities = 65/338 (19%), Positives = 138/338 (40%), Gaps = 35/338 (10%)
Query: 1 MMEDNKQLALRI-------DGAVQSASQEVTNLRAELTATNRRLAELSGGGGPGPGPGAA 53
+ ED +Q+A ++ +++ Q + AE R+AE+S
Sbjct: 2350 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS-----------R 2398
Query: 54 ASASAAGDSAATNMENPQLGAQV----LLREEVSRLQEEVHLLRQMKEMLAKDLEES--Q 107
A A A D+ + ++G ++ L +E L + + + RQ + A+ L E+ +
Sbjct: 2399 AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2458
Query: 108 GGKSSEVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLE 167
+ E L +QL +E + + ++ LQ +A ++ EK L+ + + +
Sbjct: 2459 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2518
Query: 168 SREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLD 227
E+ +D + +Q R+E + + + +E+ L E RR+ EA + + +L
Sbjct: 2519 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2578
Query: 228 LKDNRMKELEAELAMAKQSLATLTKDVPKRHSLAMPGETVLNGNQEWVVQADLPLTAAIR 287
+ + ++ E LA Q L + + ++H A+ + E V + + T +
Sbjct: 2579 QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL-------AHSEEVTASQVAATKTLP 2631
Query: 288 QSQQTL----YHSHPPHPADRQAVRVSPCHSRQPSVIS 321
+ L + P H D +VS ++ ++S
Sbjct: 2632 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS 2669
Score = 46.2 bits (108), Expect = 1e-04
Identities = 62/252 (24%), Positives = 105/252 (41%), Gaps = 34/252 (13%)
Query: 11 RIDGAVQSASQEVTNLRAELTATNRRLAELSGGGGPGPGPGAAASASAAGDSAATNMENP 70
R+ +A+Q+ L AEL + L A+ A A +S +T+ ++
Sbjct: 1742 RLQREAAAATQKRQELEAELAKVRAEMEVL-----------LASKARAEEESRSTSEKSK 1790
Query: 71 Q-----LGAQVLLREEVSRLQ---EEVHLLRQMKEMLAKDLEESQGGKSSEVLSA----- 117
Q G L EE +RL+ EE RQ+ E A +E L+A
Sbjct: 1791 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1850
Query: 118 ---TELRVQLAQKEQELARAKEALQAMKADRKRLKGE----KTDLVSQMQQLYATLESRE 170
TE + L +KE E R + + R+RL+ + K D+ ++ QL +S
Sbjct: 1851 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1910
Query: 171 EQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHA-TALRS--QLD 227
E+ + + + + R++ E+ + AL + K EL + +A LRS Q +
Sbjct: 1911 ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 1970
Query: 228 LKDNRMKELEAE 239
L+ R ++L AE
Sbjct: 1971 LEAARQRQLAAE 1982
Score = 45.8 bits (107), Expect = 2e-04
Identities = 57/226 (25%), Positives = 99/226 (43%), Gaps = 30/226 (13%)
Query: 52 AAASASAAGDSAATNMENPQLGAQVLLREEVS--------RLQEEVHLLRQMKEM-LAKD 102
A A A A + A ++ ++ +V+ REE + +QEE+ LRQ E +
Sbjct: 1382 AHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1440
Query: 103 LEESQGGKSSEVLSATELRV---QLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQM 159
+++ + S + E+RV QL E++ A+ LQA++A + + +K +
Sbjct: 1441 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA 1500
Query: 160 QQLYATLESREEQLRDFIRNYEQHRKESEDAVKA---LAKEKDLLEREKWELRRQAKEA- 215
++L Q++D + Q E VKA A+EK + ELR QA+EA
Sbjct: 1501 ERL-------RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1553
Query: 216 -----TDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPK 256
+ A + Q+ L + + EAEL + S A T + +
Sbjct: 1554 RRLRQAEVERARQVQVAL-ETAQRSAEAELQSKRASFAEKTAQLER 1598
Score = 42.4 bits (98), Expect = 0.002
Identities = 64/263 (24%), Positives = 110/263 (41%), Gaps = 35/263 (13%)
Query: 21 QEVTNLRAELTATNRRLAELSGGGGPGPGPGAAASASAAGDSAATNMENPQLGAQVLLRE 80
+E+ +R +L AT R+ GG G A A A E + + + E
Sbjct: 1456 EEIRVVRLQLEATERQR-----GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1510
Query: 81 EVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVL--SATELRVQLAQKEQELARAKE-A 137
+ Q EV L ++K E+ + ++ E L A E +L Q E E AR + A
Sbjct: 1511 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1570
Query: 138 LQ-AMKADRKRLKGEKTDLVSQMQQLYATLESRE---EQLRDFIRNYEQHRKESEDAVKA 193
L+ A ++ L+ ++ + QL +L+ QLR+ E R+ + A
Sbjct: 1571 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE-----EAERRAQQQAEAE 1625
Query: 194 LAKEKDLLEREKWE--------LRRQAKEATDHATALRSQLDLKDNRMKELEA------- 238
A+E+ E E+W+ LR QA+E + +++ + K E EA
Sbjct: 1626 RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE-KQKEEAEREARRRGKAE 1684
Query: 239 ELAMAKQSLATLTKDVPKRHSLA 261
E A+ ++ LA +++ K+ LA
Sbjct: 1685 EQAVRQRELA--EQELEKQRQLA 1705
Score = 41.6 bits (96), Expect = 0.003
Identities = 55/216 (25%), Positives = 99/216 (45%), Gaps = 21/216 (9%)
Query: 54 ASASAAGDSAATNMENPQLGAQVLLR-----EEVSRLQEEVHLLRQMKEMLAKDLEESQG 108
A A A + A +E QL A LR EEV++ Q+ + K+ + E +
Sbjct: 1622 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQ-QKSLAQAEAEKQKEEAEREARRR 1680
Query: 109 GKSSE-VLSATELRVQLAQKEQELARAKEALQAMKADRK--RLKGEKTDLVSQMQQLYAT 165
GK+ E + EL Q +K+++LA A Q + A+++ RL+ E T+ Q +QL
Sbjct: 1681 GKAEEQAVRQRELAEQELEKQRQLAEGT-AQQRLAAEQELIRLRAE-TEQGEQQRQL--- 1735
Query: 166 LESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQ 225
LE +L+ Q R+E E + + E ++L K +++ ++ + + +
Sbjct: 1736 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS---KQR 1792
Query: 226 LDLKDNRMKELEAELAMAKQSLATLTKDVPKRHSLA 261
L+ + R +EL E A L L ++ ++ LA
Sbjct: 1793 LEAEAGRFRELAEEAA----RLRALAEEAKRQRQLA 1824
Score = 41.2 bits (95), Expect = 0.004
Identities = 42/163 (25%), Positives = 74/163 (45%), Gaps = 15/163 (9%)
Query: 79 REEVSRLQEEVHLLRQMKEMLAKDLEESQG---GKSSEVLSATE----LRVQLAQKEQ-- 129
RE R + E +RQ +E+ ++LE+ + G + + L+A + LR + Q EQ
Sbjct: 1675 REARRRGKAEEQAVRQ-RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR 1733
Query: 130 -----ELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHR 184
ELAR + A R+ L+ E + ++M+ L A+ EE+ R +Q
Sbjct: 1734 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1793
Query: 185 KESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLD 227
+ + LA+E L E +RQ + A + A R++ +
Sbjct: 1794 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1836
Score = 40.8 bits (94), Expect = 0.005
Identities = 49/186 (26%), Positives = 82/186 (44%), Gaps = 21/186 (11%)
Query: 75 QVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARA 134
Q+ EE R + E R K + A++ Q + E + + +V+ A++ +E A
Sbjct: 1978 QLAAEEERRRREAEE---RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ 2034
Query: 135 KEALQ---AMKADRKRLKGEKTDLVSQMQQ----LYATLESREEQLRDFIRNYEQHRKES 187
+ A Q A +A +KRL+ E+ +QQ L TL+ + L E R+ +
Sbjct: 2035 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2094
Query: 188 EDAVKALAKEKDLLEREKWELRRQAKEA------TDHATALRSQLDLKDNRM-KELEAEL 240
E+A +A + ERE + RRQ +EA + R+Q ++ KE E E
Sbjct: 2095 EEAEEARVQA----EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2150
Query: 241 AMAKQS 246
A Q+
Sbjct: 2151 ARRAQA 2156
Score = 40.8 bits (94), Expect = 0.005
Identities = 38/178 (21%), Positives = 77/178 (43%), Gaps = 5/178 (2%)
Query: 85 LQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQA---M 141
LQEE ++Q+ E A+ +Q L+ +L Q A E+ L +A+Q +
Sbjct: 2270 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2329
Query: 142 KADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLL 201
KA+ + L+ +K Q ++L E +QL + + +++ + ++ E + L
Sbjct: 2330 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2389
Query: 202 EREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPKRHS 259
+ E+ R A + A R Q + ++ ELA ++ T ++ ++ S
Sbjct: 2390 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH--RTELATQEKVTLVQTLEIQRQQS 2445
Score = 39.3 bits (90), Expect = 0.014
Identities = 52/206 (25%), Positives = 87/206 (42%), Gaps = 30/206 (14%)
Query: 52 AAASASAAGDSAATNMENPQLGAQVLLREEVSRLQEEVHLLRQMK------EMLAKDLEE 105
A A A AA + E +E R Q E LRQ + E K E+
Sbjct: 2131 ARAQAQAAAEKLRKEAE----------QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2180
Query: 106 SQGGKSSEVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYAT 165
+ K+ T LR+QL + + + E LQ RLK E T+ Q Q+
Sbjct: 2181 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ-------RLKAEATEAARQRSQVEEE 2233
Query: 166 LESREEQLRDFIRNYEQHRKESEDAVKALAKEKD----LLEREKWELRRQAKEATDHATA 221
L S Q+ + + + R E+E+ L ++KD L+ E ++++ A+EA + A
Sbjct: 2234 LFSVRVQMEELSK--LKARIEAENRALIL-RDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2290
Query: 222 LRSQLDLKDNRMKELEAELAMAKQSL 247
+ L+ ++L + A+A++ L
Sbjct: 2291 AQEAARLRQLAEEDLAQQRALAEKML 2316
Score = 37.0 bits (84), Expect = 0.070
Identities = 51/222 (22%), Positives = 82/222 (36%), Gaps = 33/222 (14%)
Query: 53 AASASAAGDSAATNMENPQLGAQVLLREEVSRL-----QEEVHLLRQMKEMLAKDLEESQ 107
AA AA A E +L A+V EE RL QE L+ +E K L+ +
Sbjct: 1999 AAEEEAARQRKAALEEVERLKAKV---EEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2055
Query: 108 GGKSSEVLSATELRVQLAQKEQELA-----------RAKEALQAMKADRKRLKGEKTDLV 156
+ V + Q Q+EQ + RA E + + +R + V
Sbjct: 2056 KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV 2115
Query: 157 SQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKW---------- 206
+ ++L + E + + E+ RKE+E A+ + R+K
Sbjct: 2116 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2175
Query: 207 ----ELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAK 244
+ RQ + T LR QL+ D++ L+ EL K
Sbjct: 2176 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2217
Score = 33.5 bits (75), Expect = 0.77
Identities = 38/194 (19%), Positives = 77/194 (39%), Gaps = 5/194 (2%)
Query: 53 AASASAAGDSAATNMENPQLGAQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSS 112
A+ AA A +E ++ + E+ R +E+ L + LA + E +
Sbjct: 1936 ASFEKAAAGKAELELELGRIRSNA---EDTLRSKEQAELEAARQRQLAAEEERRRREAEE 1992
Query: 113 EVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQ 172
V + + A++ + E L+A + +RL+ ++ QL + Q
Sbjct: 1993 RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ 2052
Query: 173 LRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNR 232
+ + +KE E + L +E+ +L++ + E A+ A + A R Q + + +
Sbjct: 2053 AEEKAHAFAVQQKEQE-LQQTLQQEQSVLDQLRGE-AEAARRAAEEAEEARVQAEREAAQ 2110
Query: 233 MKELEAELAMAKQS 246
+ E KQS
Sbjct: 2111 SRRQVEEAERLKQS 2124
Score = 30.0 bits (66), Expect = 8.5
Identities = 41/179 (22%), Positives = 82/179 (45%), Gaps = 21/179 (11%)
Query: 74 AQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELAR 133
AQV L+ R + E LR ++++LA +EE+Q + E V L E +L
Sbjct: 508 AQVTLQSVQRRPELEDSTLRYLQDLLAW-VEENQ-----HRVDGAEWGVDLPSVEAQLGS 561
Query: 134 AK---EALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDA 190
+ ++++ +A +R + ++ L + Y R + + N + R S ++
Sbjct: 562 HRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES 621
Query: 191 VKAL--AKEKDLL---EREKWELRRQAKEATDHATA-------LRSQLDLKDNRMKELE 237
+ + A K+L+ E+E+ E+ + + TA L +L+LK+ ++KEL+
Sbjct: 622 LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQ 680
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 55.5 bits (132), Expect = 2e-07
Identities = 65/338 (19%), Positives = 138/338 (40%), Gaps = 35/338 (10%)
Query: 1 MMEDNKQLALRI-------DGAVQSASQEVTNLRAELTATNRRLAELSGGGGPGPGPGAA 53
+ ED +Q+A ++ +++ Q + AE R+AE+S
Sbjct: 2346 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS-----------R 2394
Query: 54 ASASAAGDSAATNMENPQLGAQV----LLREEVSRLQEEVHLLRQMKEMLAKDLEES--Q 107
A A A D+ + ++G ++ L +E L + + + RQ + A+ L E+ +
Sbjct: 2395 AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2454
Query: 108 GGKSSEVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLE 167
+ E L +QL +E + + ++ LQ +A ++ EK L+ + + +
Sbjct: 2455 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2514
Query: 168 SREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLD 227
E+ +D + +Q R+E + + + +E+ L E RR+ EA + + +L
Sbjct: 2515 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2574
Query: 228 LKDNRMKELEAELAMAKQSLATLTKDVPKRHSLAMPGETVLNGNQEWVVQADLPLTAAIR 287
+ + ++ E LA Q L + + ++H A+ + E V + + T +
Sbjct: 2575 QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL-------AHSEEVTASQVAATKTLP 2627
Query: 288 QSQQTL----YHSHPPHPADRQAVRVSPCHSRQPSVIS 321
+ L + P H D +VS ++ ++S
Sbjct: 2628 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS 2665
Score = 46.2 bits (108), Expect = 1e-04
Identities = 62/252 (24%), Positives = 105/252 (41%), Gaps = 34/252 (13%)
Query: 11 RIDGAVQSASQEVTNLRAELTATNRRLAELSGGGGPGPGPGAAASASAAGDSAATNMENP 70
R+ +A+Q+ L AEL + L A+ A A +S +T+ ++
Sbjct: 1738 RLQREAAAATQKRQELEAELAKVRAEMEVL-----------LASKARAEEESRSTSEKSK 1786
Query: 71 Q-----LGAQVLLREEVSRLQ---EEVHLLRQMKEMLAKDLEESQGGKSSEVLSA----- 117
Q G L EE +RL+ EE RQ+ E A +E L+A
Sbjct: 1787 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1846
Query: 118 ---TELRVQLAQKEQELARAKEALQAMKADRKRLKGE----KTDLVSQMQQLYATLESRE 170
TE + L +KE E R + + R+RL+ + K D+ ++ QL +S
Sbjct: 1847 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1906
Query: 171 EQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHA-TALRS--QLD 227
E+ + + + + R++ E+ + AL + K EL + +A LRS Q +
Sbjct: 1907 ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 1966
Query: 228 LKDNRMKELEAE 239
L+ R ++L AE
Sbjct: 1967 LEAARQRQLAAE 1978
Score = 45.8 bits (107), Expect = 2e-04
Identities = 57/226 (25%), Positives = 99/226 (43%), Gaps = 30/226 (13%)
Query: 52 AAASASAAGDSAATNMENPQLGAQVLLREEVS--------RLQEEVHLLRQMKEM-LAKD 102
A A A A + A ++ ++ +V+ REE + +QEE+ LRQ E +
Sbjct: 1378 AHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1436
Query: 103 LEESQGGKSSEVLSATELRV---QLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQM 159
+++ + S + E+RV QL E++ A+ LQA++A + + +K +
Sbjct: 1437 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA 1496
Query: 160 QQLYATLESREEQLRDFIRNYEQHRKESEDAVKA---LAKEKDLLEREKWELRRQAKEA- 215
++L Q++D + Q E VKA A+EK + ELR QA+EA
Sbjct: 1497 ERL-------RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1549
Query: 216 -----TDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPK 256
+ A + Q+ L + + EAEL + S A T + +
Sbjct: 1550 RRLRQAEVERARQVQVAL-ETAQRSAEAELQSKRASFAEKTAQLER 1594
Score = 42.4 bits (98), Expect = 0.002
Identities = 64/263 (24%), Positives = 110/263 (41%), Gaps = 35/263 (13%)
Query: 21 QEVTNLRAELTATNRRLAELSGGGGPGPGPGAAASASAAGDSAATNMENPQLGAQVLLRE 80
+E+ +R +L AT R+ GG G A A A E + + + E
Sbjct: 1452 EEIRVVRLQLEATERQR-----GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1506
Query: 81 EVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVL--SATELRVQLAQKEQELARAKE-A 137
+ Q EV L ++K E+ + ++ E L A E +L Q E E AR + A
Sbjct: 1507 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1566
Query: 138 LQ-AMKADRKRLKGEKTDLVSQMQQLYATLESRE---EQLRDFIRNYEQHRKESEDAVKA 193
L+ A ++ L+ ++ + QL +L+ QLR+ E R+ + A
Sbjct: 1567 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE-----EAERRAQQQAEAE 1621
Query: 194 LAKEKDLLEREKWE--------LRRQAKEATDHATALRSQLDLKDNRMKELEA------- 238
A+E+ E E+W+ LR QA+E + +++ + K E EA
Sbjct: 1622 RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE-KQKEEAEREARRRGKAE 1680
Query: 239 ELAMAKQSLATLTKDVPKRHSLA 261
E A+ ++ LA +++ K+ LA
Sbjct: 1681 EQAVRQRELA--EQELEKQRQLA 1701
Score = 41.6 bits (96), Expect = 0.003
Identities = 55/216 (25%), Positives = 99/216 (45%), Gaps = 21/216 (9%)
Query: 54 ASASAAGDSAATNMENPQLGAQVLLR-----EEVSRLQEEVHLLRQMKEMLAKDLEESQG 108
A A A + A +E QL A LR EEV++ Q+ + K+ + E +
Sbjct: 1618 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQ-QKSLAQAEAEKQKEEAEREARRR 1676
Query: 109 GKSSE-VLSATELRVQLAQKEQELARAKEALQAMKADRK--RLKGEKTDLVSQMQQLYAT 165
GK+ E + EL Q +K+++LA A Q + A+++ RL+ E T+ Q +QL
Sbjct: 1677 GKAEEQAVRQRELAEQELEKQRQLAEGT-AQQRLAAEQELIRLRAE-TEQGEQQRQL--- 1731
Query: 166 LESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQ 225
LE +L+ Q R+E E + + E ++L K +++ ++ + + +
Sbjct: 1732 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS---KQR 1788
Query: 226 LDLKDNRMKELEAELAMAKQSLATLTKDVPKRHSLA 261
L+ + R +EL E A L L ++ ++ LA
Sbjct: 1789 LEAEAGRFRELAEEAA----RLRALAEEAKRQRQLA 1820
Score = 41.2 bits (95), Expect = 0.004
Identities = 42/163 (25%), Positives = 74/163 (45%), Gaps = 15/163 (9%)
Query: 79 REEVSRLQEEVHLLRQMKEMLAKDLEESQG---GKSSEVLSATE----LRVQLAQKEQ-- 129
RE R + E +RQ +E+ ++LE+ + G + + L+A + LR + Q EQ
Sbjct: 1671 REARRRGKAEEQAVRQ-RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR 1729
Query: 130 -----ELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHR 184
ELAR + A R+ L+ E + ++M+ L A+ EE+ R +Q
Sbjct: 1730 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1789
Query: 185 KESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLD 227
+ + LA+E L E +RQ + A + A R++ +
Sbjct: 1790 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1832
Score = 40.8 bits (94), Expect = 0.005
Identities = 49/186 (26%), Positives = 82/186 (44%), Gaps = 21/186 (11%)
Query: 75 QVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARA 134
Q+ EE R + E R K + A++ Q + E + + +V+ A++ +E A
Sbjct: 1974 QLAAEEERRRREAEE---RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ 2030
Query: 135 KEALQ---AMKADRKRLKGEKTDLVSQMQQ----LYATLESREEQLRDFIRNYEQHRKES 187
+ A Q A +A +KRL+ E+ +QQ L TL+ + L E R+ +
Sbjct: 2031 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2090
Query: 188 EDAVKALAKEKDLLEREKWELRRQAKEA------TDHATALRSQLDLKDNRM-KELEAEL 240
E+A +A + ERE + RRQ +EA + R+Q ++ KE E E
Sbjct: 2091 EEAEEARVQA----EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2146
Query: 241 AMAKQS 246
A Q+
Sbjct: 2147 ARRAQA 2152
Score = 40.8 bits (94), Expect = 0.005
Identities = 38/178 (21%), Positives = 77/178 (43%), Gaps = 5/178 (2%)
Query: 85 LQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQA---M 141
LQEE ++Q+ E A+ +Q L+ +L Q A E+ L +A+Q +
Sbjct: 2266 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2325
Query: 142 KADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLL 201
KA+ + L+ +K Q ++L E +QL + + +++ + ++ E + L
Sbjct: 2326 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2385
Query: 202 EREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPKRHS 259
+ E+ R A + A R Q + ++ ELA ++ T ++ ++ S
Sbjct: 2386 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH--RTELATQEKVTLVQTLEIQRQQS 2441
Score = 39.3 bits (90), Expect = 0.014
Identities = 52/206 (25%), Positives = 87/206 (42%), Gaps = 30/206 (14%)
Query: 52 AAASASAAGDSAATNMENPQLGAQVLLREEVSRLQEEVHLLRQMK------EMLAKDLEE 105
A A A AA + E +E R Q E LRQ + E K E+
Sbjct: 2127 ARAQAQAAAEKLRKEAE----------QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2176
Query: 106 SQGGKSSEVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYAT 165
+ K+ T LR+QL + + + E LQ RLK E T+ Q Q+
Sbjct: 2177 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ-------RLKAEATEAARQRSQVEEE 2229
Query: 166 LESREEQLRDFIRNYEQHRKESEDAVKALAKEKD----LLEREKWELRRQAKEATDHATA 221
L S Q+ + + + R E+E+ L ++KD L+ E ++++ A+EA + A
Sbjct: 2230 LFSVRVQMEELSK--LKARIEAENRALIL-RDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2286
Query: 222 LRSQLDLKDNRMKELEAELAMAKQSL 247
+ L+ ++L + A+A++ L
Sbjct: 2287 AQEAARLRQLAEEDLAQQRALAEKML 2312
Score = 37.0 bits (84), Expect = 0.070
Identities = 51/222 (22%), Positives = 82/222 (36%), Gaps = 33/222 (14%)
Query: 53 AASASAAGDSAATNMENPQLGAQVLLREEVSRL-----QEEVHLLRQMKEMLAKDLEESQ 107
AA AA A E +L A+V EE RL QE L+ +E K L+ +
Sbjct: 1995 AAEEEAARQRKAALEEVERLKAKV---EEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2051
Query: 108 GGKSSEVLSATELRVQLAQKEQELA-----------RAKEALQAMKADRKRLKGEKTDLV 156
+ V + Q Q+EQ + RA E + + +R + V
Sbjct: 2052 KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV 2111
Query: 157 SQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKW---------- 206
+ ++L + E + + E+ RKE+E A+ + R+K
Sbjct: 2112 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2171
Query: 207 ----ELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAK 244
+ RQ + T LR QL+ D++ L+ EL K
Sbjct: 2172 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2213
Score = 33.5 bits (75), Expect = 0.77
Identities = 38/194 (19%), Positives = 77/194 (39%), Gaps = 5/194 (2%)
Query: 53 AASASAAGDSAATNMENPQLGAQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSS 112
A+ AA A +E ++ + E+ R +E+ L + LA + E +
Sbjct: 1932 ASFEKAAAGKAELELELGRIRSNA---EDTLRSKEQAELEAARQRQLAAEEERRRREAEE 1988
Query: 113 EVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQ 172
V + + A++ + E L+A + +RL+ ++ QL + Q
Sbjct: 1989 RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ 2048
Query: 173 LRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNR 232
+ + +KE E + L +E+ +L++ + E A+ A + A R Q + + +
Sbjct: 2049 AEEKAHAFAVQQKEQE-LQQTLQQEQSVLDQLRGE-AEAARRAAEEAEEARVQAEREAAQ 2106
Query: 233 MKELEAELAMAKQS 246
+ E KQS
Sbjct: 2107 SRRQVEEAERLKQS 2120
Score = 30.0 bits (66), Expect = 8.5
Identities = 41/179 (22%), Positives = 82/179 (45%), Gaps = 21/179 (11%)
Query: 74 AQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELAR 133
AQV L+ R + E LR ++++LA +EE+Q + E V L E +L
Sbjct: 504 AQVTLQSVQRRPELEDSTLRYLQDLLAW-VEENQ-----HRVDGAEWGVDLPSVEAQLGS 557
Query: 134 AK---EALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDA 190
+ ++++ +A +R + ++ L + Y R + + N + R S ++
Sbjct: 558 HRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES 617
Query: 191 VKAL--AKEKDLL---EREKWELRRQAKEATDHATA-------LRSQLDLKDNRMKELE 237
+ + A K+L+ E+E+ E+ + + TA L +L+LK+ ++KEL+
Sbjct: 618 LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQ 676
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 55.5 bits (132), Expect = 2e-07
Identities = 65/338 (19%), Positives = 138/338 (40%), Gaps = 35/338 (10%)
Query: 1 MMEDNKQLALRI-------DGAVQSASQEVTNLRAELTATNRRLAELSGGGGPGPGPGAA 53
+ ED +Q+A ++ +++ Q + AE R+AE+S
Sbjct: 2314 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS-----------R 2362
Query: 54 ASASAAGDSAATNMENPQLGAQV----LLREEVSRLQEEVHLLRQMKEMLAKDLEES--Q 107
A A A D+ + ++G ++ L +E L + + + RQ + A+ L E+ +
Sbjct: 2363 AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2422
Query: 108 GGKSSEVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLE 167
+ E L +QL +E + + ++ LQ +A ++ EK L+ + + +
Sbjct: 2423 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2482
Query: 168 SREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLD 227
E+ +D + +Q R+E + + + +E+ L E RR+ EA + + +L
Sbjct: 2483 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2542
Query: 228 LKDNRMKELEAELAMAKQSLATLTKDVPKRHSLAMPGETVLNGNQEWVVQADLPLTAAIR 287
+ + ++ E LA Q L + + ++H A+ + E V + + T +
Sbjct: 2543 QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL-------AHSEEVTASQVAATKTLP 2595
Query: 288 QSQQTL----YHSHPPHPADRQAVRVSPCHSRQPSVIS 321
+ L + P H D +VS ++ ++S
Sbjct: 2596 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS 2633
Score = 46.2 bits (108), Expect = 1e-04
Identities = 62/252 (24%), Positives = 105/252 (41%), Gaps = 34/252 (13%)
Query: 11 RIDGAVQSASQEVTNLRAELTATNRRLAELSGGGGPGPGPGAAASASAAGDSAATNMENP 70
R+ +A+Q+ L AEL + L A+ A A +S +T+ ++
Sbjct: 1706 RLQREAAAATQKRQELEAELAKVRAEMEVL-----------LASKARAEEESRSTSEKSK 1754
Query: 71 Q-----LGAQVLLREEVSRLQ---EEVHLLRQMKEMLAKDLEESQGGKSSEVLSA----- 117
Q G L EE +RL+ EE RQ+ E A +E L+A
Sbjct: 1755 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1814
Query: 118 ---TELRVQLAQKEQELARAKEALQAMKADRKRLKGE----KTDLVSQMQQLYATLESRE 170
TE + L +KE E R + + R+RL+ + K D+ ++ QL +S
Sbjct: 1815 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1874
Query: 171 EQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHA-TALRS--QLD 227
E+ + + + + R++ E+ + AL + K EL + +A LRS Q +
Sbjct: 1875 ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 1934
Query: 228 LKDNRMKELEAE 239
L+ R ++L AE
Sbjct: 1935 LEAARQRQLAAE 1946
Score = 45.8 bits (107), Expect = 2e-04
Identities = 57/226 (25%), Positives = 99/226 (43%), Gaps = 30/226 (13%)
Query: 52 AAASASAAGDSAATNMENPQLGAQVLLREEVS--------RLQEEVHLLRQMKEM-LAKD 102
A A A A + A ++ ++ +V+ REE + +QEE+ LRQ E +
Sbjct: 1346 AHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1404
Query: 103 LEESQGGKSSEVLSATELRV---QLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQM 159
+++ + S + E+RV QL E++ A+ LQA++A + + +K +
Sbjct: 1405 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA 1464
Query: 160 QQLYATLESREEQLRDFIRNYEQHRKESEDAVKA---LAKEKDLLEREKWELRRQAKEA- 215
++L Q++D + Q E VKA A+EK + ELR QA+EA
Sbjct: 1465 ERL-------RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1517
Query: 216 -----TDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPK 256
+ A + Q+ L + + EAEL + S A T + +
Sbjct: 1518 RRLRQAEVERARQVQVAL-ETAQRSAEAELQSKRASFAEKTAQLER 1562
Score = 42.4 bits (98), Expect = 0.002
Identities = 64/263 (24%), Positives = 110/263 (41%), Gaps = 35/263 (13%)
Query: 21 QEVTNLRAELTATNRRLAELSGGGGPGPGPGAAASASAAGDSAATNMENPQLGAQVLLRE 80
+E+ +R +L AT R+ GG G A A A E + + + E
Sbjct: 1420 EEIRVVRLQLEATERQR-----GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1474
Query: 81 EVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVL--SATELRVQLAQKEQELARAKE-A 137
+ Q EV L ++K E+ + ++ E L A E +L Q E E AR + A
Sbjct: 1475 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1534
Query: 138 LQ-AMKADRKRLKGEKTDLVSQMQQLYATLESRE---EQLRDFIRNYEQHRKESEDAVKA 193
L+ A ++ L+ ++ + QL +L+ QLR+ E R+ + A
Sbjct: 1535 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE-----EAERRAQQQAEAE 1589
Query: 194 LAKEKDLLEREKWE--------LRRQAKEATDHATALRSQLDLKDNRMKELEA------- 238
A+E+ E E+W+ LR QA+E + +++ + K E EA
Sbjct: 1590 RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE-KQKEEAEREARRRGKAE 1648
Query: 239 ELAMAKQSLATLTKDVPKRHSLA 261
E A+ ++ LA +++ K+ LA
Sbjct: 1649 EQAVRQRELA--EQELEKQRQLA 1669
Score = 41.6 bits (96), Expect = 0.003
Identities = 55/216 (25%), Positives = 99/216 (45%), Gaps = 21/216 (9%)
Query: 54 ASASAAGDSAATNMENPQLGAQVLLR-----EEVSRLQEEVHLLRQMKEMLAKDLEESQG 108
A A A + A +E QL A LR EEV++ Q+ + K+ + E +
Sbjct: 1586 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQ-QKSLAQAEAEKQKEEAEREARRR 1644
Query: 109 GKSSE-VLSATELRVQLAQKEQELARAKEALQAMKADRK--RLKGEKTDLVSQMQQLYAT 165
GK+ E + EL Q +K+++LA A Q + A+++ RL+ E T+ Q +QL
Sbjct: 1645 GKAEEQAVRQRELAEQELEKQRQLAEGT-AQQRLAAEQELIRLRAE-TEQGEQQRQL--- 1699
Query: 166 LESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQ 225
LE +L+ Q R+E E + + E ++L K +++ ++ + + +
Sbjct: 1700 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS---KQR 1756
Query: 226 LDLKDNRMKELEAELAMAKQSLATLTKDVPKRHSLA 261
L+ + R +EL E A L L ++ ++ LA
Sbjct: 1757 LEAEAGRFRELAEEAA----RLRALAEEAKRQRQLA 1788
Score = 41.2 bits (95), Expect = 0.004
Identities = 42/163 (25%), Positives = 74/163 (45%), Gaps = 15/163 (9%)
Query: 79 REEVSRLQEEVHLLRQMKEMLAKDLEESQG---GKSSEVLSATE----LRVQLAQKEQ-- 129
RE R + E +RQ +E+ ++LE+ + G + + L+A + LR + Q EQ
Sbjct: 1639 REARRRGKAEEQAVRQ-RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR 1697
Query: 130 -----ELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHR 184
ELAR + A R+ L+ E + ++M+ L A+ EE+ R +Q
Sbjct: 1698 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1757
Query: 185 KESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLD 227
+ + LA+E L E +RQ + A + A R++ +
Sbjct: 1758 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1800
Score = 40.8 bits (94), Expect = 0.005
Identities = 49/186 (26%), Positives = 82/186 (44%), Gaps = 21/186 (11%)
Query: 75 QVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARA 134
Q+ EE R + E R K + A++ Q + E + + +V+ A++ +E A
Sbjct: 1942 QLAAEEERRRREAEE---RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ 1998
Query: 135 KEALQ---AMKADRKRLKGEKTDLVSQMQQ----LYATLESREEQLRDFIRNYEQHRKES 187
+ A Q A +A +KRL+ E+ +QQ L TL+ + L E R+ +
Sbjct: 1999 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2058
Query: 188 EDAVKALAKEKDLLEREKWELRRQAKEA------TDHATALRSQLDLKDNRM-KELEAEL 240
E+A +A + ERE + RRQ +EA + R+Q ++ KE E E
Sbjct: 2059 EEAEEARVQA----EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2114
Query: 241 AMAKQS 246
A Q+
Sbjct: 2115 ARRAQA 2120
Score = 40.8 bits (94), Expect = 0.005
Identities = 38/178 (21%), Positives = 77/178 (43%), Gaps = 5/178 (2%)
Query: 85 LQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQA---M 141
LQEE ++Q+ E A+ +Q L+ +L Q A E+ L +A+Q +
Sbjct: 2234 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2293
Query: 142 KADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLL 201
KA+ + L+ +K Q ++L E +QL + + +++ + ++ E + L
Sbjct: 2294 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2353
Query: 202 EREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPKRHS 259
+ E+ R A + A R Q + ++ ELA ++ T ++ ++ S
Sbjct: 2354 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH--RTELATQEKVTLVQTLEIQRQQS 2409
Score = 39.3 bits (90), Expect = 0.014
Identities = 52/206 (25%), Positives = 87/206 (42%), Gaps = 30/206 (14%)
Query: 52 AAASASAAGDSAATNMENPQLGAQVLLREEVSRLQEEVHLLRQMK------EMLAKDLEE 105
A A A AA + E +E R Q E LRQ + E K E+
Sbjct: 2095 ARAQAQAAAEKLRKEAE----------QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2144
Query: 106 SQGGKSSEVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYAT 165
+ K+ T LR+QL + + + E LQ RLK E T+ Q Q+
Sbjct: 2145 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ-------RLKAEATEAARQRSQVEEE 2197
Query: 166 LESREEQLRDFIRNYEQHRKESEDAVKALAKEKD----LLEREKWELRRQAKEATDHATA 221
L S Q+ + + + R E+E+ L ++KD L+ E ++++ A+EA + A
Sbjct: 2198 LFSVRVQMEELSK--LKARIEAENRALIL-RDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2254
Query: 222 LRSQLDLKDNRMKELEAELAMAKQSL 247
+ L+ ++L + A+A++ L
Sbjct: 2255 AQEAARLRQLAEEDLAQQRALAEKML 2280
Score = 37.0 bits (84), Expect = 0.070
Identities = 51/222 (22%), Positives = 82/222 (36%), Gaps = 33/222 (14%)
Query: 53 AASASAAGDSAATNMENPQLGAQVLLREEVSRL-----QEEVHLLRQMKEMLAKDLEESQ 107
AA AA A E +L A+V EE RL QE L+ +E K L+ +
Sbjct: 1963 AAEEEAARQRKAALEEVERLKAKV---EEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2019
Query: 108 GGKSSEVLSATELRVQLAQKEQELA-----------RAKEALQAMKADRKRLKGEKTDLV 156
+ V + Q Q+EQ + RA E + + +R + V
Sbjct: 2020 KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV 2079
Query: 157 SQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKW---------- 206
+ ++L + E + + E+ RKE+E A+ + R+K
Sbjct: 2080 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2139
Query: 207 ----ELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAK 244
+ RQ + T LR QL+ D++ L+ EL K
Sbjct: 2140 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2181
Score = 33.5 bits (75), Expect = 0.77
Identities = 38/194 (19%), Positives = 77/194 (39%), Gaps = 5/194 (2%)
Query: 53 AASASAAGDSAATNMENPQLGAQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSS 112
A+ AA A +E ++ + E+ R +E+ L + LA + E +
Sbjct: 1900 ASFEKAAAGKAELELELGRIRSNA---EDTLRSKEQAELEAARQRQLAAEEERRRREAEE 1956
Query: 113 EVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQ 172
V + + A++ + E L+A + +RL+ ++ QL + Q
Sbjct: 1957 RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ 2016
Query: 173 LRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNR 232
+ + +KE E + L +E+ +L++ + E A+ A + A R Q + + +
Sbjct: 2017 AEEKAHAFAVQQKEQE-LQQTLQQEQSVLDQLRGE-AEAARRAAEEAEEARVQAEREAAQ 2074
Query: 233 MKELEAELAMAKQS 246
+ E KQS
Sbjct: 2075 SRRQVEEAERLKQS 2088
Score = 30.0 bits (66), Expect = 8.5
Identities = 41/179 (22%), Positives = 82/179 (45%), Gaps = 21/179 (11%)
Query: 74 AQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELAR 133
AQV L+ R + E LR ++++LA +EE+Q + E V L E +L
Sbjct: 472 AQVTLQSVQRRPELEDSTLRYLQDLLAW-VEENQ-----HRVDGAEWGVDLPSVEAQLGS 525
Query: 134 AK---EALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDA 190
+ ++++ +A +R + ++ L + Y R + + N + R S ++
Sbjct: 526 HRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES 585
Query: 191 VKAL--AKEKDLL---EREKWELRRQAKEATDHATA-------LRSQLDLKDNRMKELE 237
+ + A K+L+ E+E+ E+ + + TA L +L+LK+ ++KEL+
Sbjct: 586 LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQ 644
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 55.5 bits (132), Expect = 2e-07
Identities = 65/338 (19%), Positives = 138/338 (40%), Gaps = 35/338 (10%)
Query: 1 MMEDNKQLALRI-------DGAVQSASQEVTNLRAELTATNRRLAELSGGGGPGPGPGAA 53
+ ED +Q+A ++ +++ Q + AE R+AE+S
Sbjct: 2483 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS-----------R 2531
Query: 54 ASASAAGDSAATNMENPQLGAQV----LLREEVSRLQEEVHLLRQMKEMLAKDLEES--Q 107
A A A D+ + ++G ++ L +E L + + + RQ + A+ L E+ +
Sbjct: 2532 AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2591
Query: 108 GGKSSEVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLE 167
+ E L +QL +E + + ++ LQ +A ++ EK L+ + + +
Sbjct: 2592 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2651
Query: 168 SREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLD 227
E+ +D + +Q R+E + + + +E+ L E RR+ EA + + +L
Sbjct: 2652 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2711
Query: 228 LKDNRMKELEAELAMAKQSLATLTKDVPKRHSLAMPGETVLNGNQEWVVQADLPLTAAIR 287
+ + ++ E LA Q L + + ++H A+ + E V + + T +
Sbjct: 2712 QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL-------AHSEEVTASQVAATKTLP 2764
Query: 288 QSQQTL----YHSHPPHPADRQAVRVSPCHSRQPSVIS 321
+ L + P H D +VS ++ ++S
Sbjct: 2765 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS 2802
Score = 46.2 bits (108), Expect = 1e-04
Identities = 62/252 (24%), Positives = 105/252 (41%), Gaps = 34/252 (13%)
Query: 11 RIDGAVQSASQEVTNLRAELTATNRRLAELSGGGGPGPGPGAAASASAAGDSAATNMENP 70
R+ +A+Q+ L AEL + L A+ A A +S +T+ ++
Sbjct: 1875 RLQREAAAATQKRQELEAELAKVRAEMEVL-----------LASKARAEEESRSTSEKSK 1923
Query: 71 Q-----LGAQVLLREEVSRLQ---EEVHLLRQMKEMLAKDLEESQGGKSSEVLSA----- 117
Q G L EE +RL+ EE RQ+ E A +E L+A
Sbjct: 1924 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1983
Query: 118 ---TELRVQLAQKEQELARAKEALQAMKADRKRLKGE----KTDLVSQMQQLYATLESRE 170
TE + L +KE E R + + R+RL+ + K D+ ++ QL +S
Sbjct: 1984 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 2043
Query: 171 EQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHA-TALRS--QLD 227
E+ + + + + R++ E+ + AL + K EL + +A LRS Q +
Sbjct: 2044 ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 2103
Query: 228 LKDNRMKELEAE 239
L+ R ++L AE
Sbjct: 2104 LEAARQRQLAAE 2115
Score = 45.8 bits (107), Expect = 2e-04
Identities = 57/226 (25%), Positives = 99/226 (43%), Gaps = 30/226 (13%)
Query: 52 AAASASAAGDSAATNMENPQLGAQVLLREEVS--------RLQEEVHLLRQMKEM-LAKD 102
A A A A + A ++ ++ +V+ REE + +QEE+ LRQ E +
Sbjct: 1515 AHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1573
Query: 103 LEESQGGKSSEVLSATELRV---QLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQM 159
+++ + S + E+RV QL E++ A+ LQA++A + + +K +
Sbjct: 1574 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA 1633
Query: 160 QQLYATLESREEQLRDFIRNYEQHRKESEDAVKA---LAKEKDLLEREKWELRRQAKEA- 215
++L Q++D + Q E VKA A+EK + ELR QA+EA
Sbjct: 1634 ERL-------RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1686
Query: 216 -----TDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPK 256
+ A + Q+ L + + EAEL + S A T + +
Sbjct: 1687 RRLRQAEVERARQVQVAL-ETAQRSAEAELQSKRASFAEKTAQLER 1731
Score = 42.4 bits (98), Expect = 0.002
Identities = 64/263 (24%), Positives = 110/263 (41%), Gaps = 35/263 (13%)
Query: 21 QEVTNLRAELTATNRRLAELSGGGGPGPGPGAAASASAAGDSAATNMENPQLGAQVLLRE 80
+E+ +R +L AT R+ GG G A A A E + + + E
Sbjct: 1589 EEIRVVRLQLEATERQR-----GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1643
Query: 81 EVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVL--SATELRVQLAQKEQELARAKE-A 137
+ Q EV L ++K E+ + ++ E L A E +L Q E E AR + A
Sbjct: 1644 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1703
Query: 138 LQ-AMKADRKRLKGEKTDLVSQMQQLYATLESRE---EQLRDFIRNYEQHRKESEDAVKA 193
L+ A ++ L+ ++ + QL +L+ QLR+ E R+ + A
Sbjct: 1704 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE-----EAERRAQQQAEAE 1758
Query: 194 LAKEKDLLEREKWE--------LRRQAKEATDHATALRSQLDLKDNRMKELEA------- 238
A+E+ E E+W+ LR QA+E + +++ + K E EA
Sbjct: 1759 RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE-KQKEEAEREARRRGKAE 1817
Query: 239 ELAMAKQSLATLTKDVPKRHSLA 261
E A+ ++ LA +++ K+ LA
Sbjct: 1818 EQAVRQRELA--EQELEKQRQLA 1838
Score = 41.6 bits (96), Expect = 0.003
Identities = 55/216 (25%), Positives = 99/216 (45%), Gaps = 21/216 (9%)
Query: 54 ASASAAGDSAATNMENPQLGAQVLLR-----EEVSRLQEEVHLLRQMKEMLAKDLEESQG 108
A A A + A +E QL A LR EEV++ Q+ + K+ + E +
Sbjct: 1755 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQ-QKSLAQAEAEKQKEEAEREARRR 1813
Query: 109 GKSSE-VLSATELRVQLAQKEQELARAKEALQAMKADRK--RLKGEKTDLVSQMQQLYAT 165
GK+ E + EL Q +K+++LA A Q + A+++ RL+ E T+ Q +QL
Sbjct: 1814 GKAEEQAVRQRELAEQELEKQRQLAEGT-AQQRLAAEQELIRLRAE-TEQGEQQRQL--- 1868
Query: 166 LESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQ 225
LE +L+ Q R+E E + + E ++L K +++ ++ + + +
Sbjct: 1869 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS---KQR 1925
Query: 226 LDLKDNRMKELEAELAMAKQSLATLTKDVPKRHSLA 261
L+ + R +EL E A L L ++ ++ LA
Sbjct: 1926 LEAEAGRFRELAEEAA----RLRALAEEAKRQRQLA 1957
Score = 41.2 bits (95), Expect = 0.004
Identities = 42/163 (25%), Positives = 74/163 (45%), Gaps = 15/163 (9%)
Query: 79 REEVSRLQEEVHLLRQMKEMLAKDLEESQG---GKSSEVLSATE----LRVQLAQKEQ-- 129
RE R + E +RQ +E+ ++LE+ + G + + L+A + LR + Q EQ
Sbjct: 1808 REARRRGKAEEQAVRQ-RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR 1866
Query: 130 -----ELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHR 184
ELAR + A R+ L+ E + ++M+ L A+ EE+ R +Q
Sbjct: 1867 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1926
Query: 185 KESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLD 227
+ + LA+E L E +RQ + A + A R++ +
Sbjct: 1927 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1969
Score = 40.8 bits (94), Expect = 0.005
Identities = 49/186 (26%), Positives = 82/186 (44%), Gaps = 21/186 (11%)
Query: 75 QVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARA 134
Q+ EE R + E R K + A++ Q + E + + +V+ A++ +E A
Sbjct: 2111 QLAAEEERRRREAEE---RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ 2167
Query: 135 KEALQ---AMKADRKRLKGEKTDLVSQMQQ----LYATLESREEQLRDFIRNYEQHRKES 187
+ A Q A +A +KRL+ E+ +QQ L TL+ + L E R+ +
Sbjct: 2168 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2227
Query: 188 EDAVKALAKEKDLLEREKWELRRQAKEA------TDHATALRSQLDLKDNRM-KELEAEL 240
E+A +A + ERE + RRQ +EA + R+Q ++ KE E E
Sbjct: 2228 EEAEEARVQA----EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2283
Query: 241 AMAKQS 246
A Q+
Sbjct: 2284 ARRAQA 2289
Score = 40.8 bits (94), Expect = 0.005
Identities = 38/178 (21%), Positives = 77/178 (43%), Gaps = 5/178 (2%)
Query: 85 LQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQA---M 141
LQEE ++Q+ E A+ +Q L+ +L Q A E+ L +A+Q +
Sbjct: 2403 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2462
Query: 142 KADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLL 201
KA+ + L+ +K Q ++L E +QL + + +++ + ++ E + L
Sbjct: 2463 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2522
Query: 202 EREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPKRHS 259
+ E+ R A + A R Q + ++ ELA ++ T ++ ++ S
Sbjct: 2523 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH--RTELATQEKVTLVQTLEIQRQQS 2578
Score = 39.3 bits (90), Expect = 0.014
Identities = 52/206 (25%), Positives = 87/206 (42%), Gaps = 30/206 (14%)
Query: 52 AAASASAAGDSAATNMENPQLGAQVLLREEVSRLQEEVHLLRQMK------EMLAKDLEE 105
A A A AA + E +E R Q E LRQ + E K E+
Sbjct: 2264 ARAQAQAAAEKLRKEAE----------QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2313
Query: 106 SQGGKSSEVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYAT 165
+ K+ T LR+QL + + + E LQ RLK E T+ Q Q+
Sbjct: 2314 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ-------RLKAEATEAARQRSQVEEE 2366
Query: 166 LESREEQLRDFIRNYEQHRKESEDAVKALAKEKD----LLEREKWELRRQAKEATDHATA 221
L S Q+ + + + R E+E+ L ++KD L+ E ++++ A+EA + A
Sbjct: 2367 LFSVRVQMEELSK--LKARIEAENRALIL-RDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2423
Query: 222 LRSQLDLKDNRMKELEAELAMAKQSL 247
+ L+ ++L + A+A++ L
Sbjct: 2424 AQEAARLRQLAEEDLAQQRALAEKML 2449
Score = 37.0 bits (84), Expect = 0.070
Identities = 51/222 (22%), Positives = 82/222 (36%), Gaps = 33/222 (14%)
Query: 53 AASASAAGDSAATNMENPQLGAQVLLREEVSRL-----QEEVHLLRQMKEMLAKDLEESQ 107
AA AA A E +L A+V EE RL QE L+ +E K L+ +
Sbjct: 2132 AAEEEAARQRKAALEEVERLKAKV---EEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2188
Query: 108 GGKSSEVLSATELRVQLAQKEQELA-----------RAKEALQAMKADRKRLKGEKTDLV 156
+ V + Q Q+EQ + RA E + + +R + V
Sbjct: 2189 KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV 2248
Query: 157 SQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKW---------- 206
+ ++L + E + + E+ RKE+E A+ + R+K
Sbjct: 2249 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2308
Query: 207 ----ELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAK 244
+ RQ + T LR QL+ D++ L+ EL K
Sbjct: 2309 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2350
Score = 33.5 bits (75), Expect = 0.77
Identities = 38/194 (19%), Positives = 77/194 (39%), Gaps = 5/194 (2%)
Query: 53 AASASAAGDSAATNMENPQLGAQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSS 112
A+ AA A +E ++ + E+ R +E+ L + LA + E +
Sbjct: 2069 ASFEKAAAGKAELELELGRIRSNA---EDTLRSKEQAELEAARQRQLAAEEERRRREAEE 2125
Query: 113 EVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQ 172
V + + A++ + E L+A + +RL+ ++ QL + Q
Sbjct: 2126 RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ 2185
Query: 173 LRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNR 232
+ + +KE E + L +E+ +L++ + E A+ A + A R Q + + +
Sbjct: 2186 AEEKAHAFAVQQKEQE-LQQTLQQEQSVLDQLRGE-AEAARRAAEEAEEARVQAEREAAQ 2243
Query: 233 MKELEAELAMAKQS 246
+ E KQS
Sbjct: 2244 SRRQVEEAERLKQS 2257
Score = 30.0 bits (66), Expect = 8.5
Identities = 41/179 (22%), Positives = 82/179 (45%), Gaps = 21/179 (11%)
Query: 74 AQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELAR 133
AQV L+ R + E LR ++++LA +EE+Q + E V L E +L
Sbjct: 641 AQVTLQSVQRRPELEDSTLRYLQDLLAW-VEENQ-----HRVDGAEWGVDLPSVEAQLGS 694
Query: 134 AK---EALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDA 190
+ ++++ +A +R + ++ L + Y R + + N + R S ++
Sbjct: 695 HRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES 754
Query: 191 VKAL--AKEKDLL---EREKWELRRQAKEATDHATA-------LRSQLDLKDNRMKELE 237
+ + A K+L+ E+E+ E+ + + TA L +L+LK+ ++KEL+
Sbjct: 755 LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQ 813
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.128 0.359
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,261,895
Number of Sequences: 37866
Number of extensions: 1366850
Number of successful extensions: 12463
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 313
Number of HSP's successfully gapped in prelim test: 805
Number of HSP's that attempted gapping in prelim test: 8192
Number of HSP's gapped (non-prelim): 3627
length of query: 775
length of database: 18,247,518
effective HSP length: 110
effective length of query: 665
effective length of database: 14,082,258
effective search space: 9364701570
effective search space used: 9364701570
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.