Guide to the Human Genome
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Search of human proteins with 157738615

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|157738615 coiled-coil alpha-helical rod protein 1 isoform 1
[Homo sapiens]
         (871 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|157738615 coiled-coil alpha-helical rod protein 1 isoform 1 [...  1672   0.0  
gi|157738613 coiled-coil alpha-helical rod protein 1 isoform 2 [...  1579   0.0  
gi|157738611 coiled-coil alpha-helical rod protein 1 isoform 3 [...  1473   0.0  
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                       119   2e-26
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                       119   2e-26
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                        119   2e-26
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                        119   2e-26
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                        119   2e-26
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                        119   2e-26
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                        119   2e-26
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                        119   2e-26
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]               118   2e-26
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ...   118   2e-26
gi|148746195 trichohyalin [Homo sapiens]                              115   2e-25
gi|16262452 cingulin [Homo sapiens]                                   114   5e-25
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ...   109   1e-23
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]    109   1e-23
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]   108   3e-23
gi|45439327 periplakin [Homo sapiens]                                 107   6e-23
gi|21735548 centrosomal protein 2 [Homo sapiens]                      106   8e-23
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]          106   1e-22
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]          106   1e-22
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]          106   1e-22
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]        105   2e-22
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s...   104   4e-22
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]                  103   5e-22
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...   103   7e-22
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...   103   7e-22
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...   103   7e-22
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...   103   7e-22

>gi|157738615 coiled-coil alpha-helical rod protein 1 isoform 1
           [Homo sapiens]
          Length = 871

 Score = 1672 bits (4331), Expect = 0.0
 Identities = 871/871 (100%), Positives = 871/871 (100%)

Query: 1   MWPHSAGARPWASTLTGKDPRVMACWCLDGLPSGLAEPWRELWRWRSRPLHCVPPFSPLA 60
           MWPHSAGARPWASTLTGKDPRVMACWCLDGLPSGLAEPWRELWRWRSRPLHCVPPFSPLA
Sbjct: 1   MWPHSAGARPWASTLTGKDPRVMACWCLDGLPSGLAEPWRELWRWRSRPLHCVPPFSPLA 60

Query: 61  RSSRDHRNLRRRGNIDGWRQNLEPSNNVEMFPPSGSTGLIPPSHFQARPLSTLPRMAPTW 120
           RSSRDHRNLRRRGNIDGWRQNLEPSNNVEMFPPSGSTGLIPPSHFQARPLSTLPRMAPTW
Sbjct: 61  RSSRDHRNLRRRGNIDGWRQNLEPSNNVEMFPPSGSTGLIPPSHFQARPLSTLPRMAPTW 120

Query: 121 LSDIPLVQPPGHQDVSERRLDTQRPQVTMWERDVSSDRQEPGRRGRSWGLEGSQALSQQA 180
           LSDIPLVQPPGHQDVSERRLDTQRPQVTMWERDVSSDRQEPGRRGRSWGLEGSQALSQQA
Sbjct: 121 LSDIPLVQPPGHQDVSERRLDTQRPQVTMWERDVSSDRQEPGRRGRSWGLEGSQALSQQA 180

Query: 181 EVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALA 240
           EVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALA
Sbjct: 181 EVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALA 240

Query: 241 GAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRR 300
           GAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRR
Sbjct: 241 GAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRR 300

Query: 301 AGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQ 360
           AGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQ
Sbjct: 301 AGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQ 360

Query: 361 KLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQ 420
           KLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQ
Sbjct: 361 KLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQ 420

Query: 421 SLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDKA 480
           SLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDKA
Sbjct: 421 SLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDKA 480

Query: 481 AEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVE 540
           AEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVE
Sbjct: 481 AEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVE 540

Query: 541 GAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREE 600
           GAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREE
Sbjct: 541 GAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREE 600

Query: 601 RNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEV 660
           RNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEV
Sbjct: 601 RNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEV 660

Query: 661 ARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHA 720
           ARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHA
Sbjct: 661 ARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHA 720

Query: 721 KAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEG 780
           KAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEG
Sbjct: 721 KAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEG 780

Query: 781 LLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGSLSVLLDDL 840
           LLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGSLSVLLDDL
Sbjct: 781 LLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGSLSVLLDDL 840

Query: 841 QDLSEAISKEEAVCQGDNLDRCSSSNPQMSS 871
           QDLSEAISKEEAVCQGDNLDRCSSSNPQMSS
Sbjct: 841 QDLSEAISKEEAVCQGDNLDRCSSSNPQMSS 871


>gi|157738613 coiled-coil alpha-helical rod protein 1 isoform 2
           [Homo sapiens]
          Length = 835

 Score = 1579 bits (4089), Expect = 0.0
 Identities = 835/871 (95%), Positives = 835/871 (95%), Gaps = 36/871 (4%)

Query: 1   MWPHSAGARPWASTLTGKDPRVMACWCLDGLPSGLAEPWRELWRWRSRPLHCVPPFSPLA 60
           MWPHSAGARPWASTLTGKDPRVMACWCLDGLPSGLAEPWRELWRWRSRPLHCVPPFSPLA
Sbjct: 1   MWPHSAGARPWASTLTGKDPRVMACWCLDGLPSGLAEPWRELWRWRSRPLHCVPPFSPLA 60

Query: 61  RSSRDHRNLRRRGNIDGWRQNLEPSNNVEMFPPSGSTGLIPPSHFQARPLSTLPRMAPTW 120
           RSSRDHRNLRRRGNIDGWRQNLEPSNNVEMFPPSG                         
Sbjct: 61  RSSRDHRNLRRRGNIDGWRQNLEPSNNVEMFPPSG------------------------- 95

Query: 121 LSDIPLVQPPGHQDVSERRLDTQRPQVTMWERDVSSDRQEPGRRGRSWGLEGSQALSQQA 180
                      HQDVSERRLDTQRPQVTMWERDVSSDRQEPGRRGRSWGLEGSQALSQQA
Sbjct: 96  -----------HQDVSERRLDTQRPQVTMWERDVSSDRQEPGRRGRSWGLEGSQALSQQA 144

Query: 181 EVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALA 240
           EVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALA
Sbjct: 145 EVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALA 204

Query: 241 GAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRR 300
           GAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRR
Sbjct: 205 GAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRR 264

Query: 301 AGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQ 360
           AGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQ
Sbjct: 265 AGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQ 324

Query: 361 KLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQ 420
           KLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQ
Sbjct: 325 KLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQ 384

Query: 421 SLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDKA 480
           SLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDKA
Sbjct: 385 SLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDKA 444

Query: 481 AEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVE 540
           AEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVE
Sbjct: 445 AEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVE 504

Query: 541 GAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREE 600
           GAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREE
Sbjct: 505 GAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREE 564

Query: 601 RNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEV 660
           RNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEV
Sbjct: 565 RNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEV 624

Query: 661 ARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHA 720
           ARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHA
Sbjct: 625 ARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHA 684

Query: 721 KAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEG 780
           KAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEG
Sbjct: 685 KAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEG 744

Query: 781 LLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGSLSVLLDDL 840
           LLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGSLSVLLDDL
Sbjct: 745 LLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGSLSVLLDDL 804

Query: 841 QDLSEAISKEEAVCQGDNLDRCSSSNPQMSS 871
           QDLSEAISKEEAVCQGDNLDRCSSSNPQMSS
Sbjct: 805 QDLSEAISKEEAVCQGDNLDRCSSSNPQMSS 835


>gi|157738611 coiled-coil alpha-helical rod protein 1 isoform 3
           [Homo sapiens]
          Length = 782

 Score = 1473 bits (3814), Expect = 0.0
 Identities = 782/782 (100%), Positives = 782/782 (100%)

Query: 90  MFPPSGSTGLIPPSHFQARPLSTLPRMAPTWLSDIPLVQPPGHQDVSERRLDTQRPQVTM 149
           MFPPSGSTGLIPPSHFQARPLSTLPRMAPTWLSDIPLVQPPGHQDVSERRLDTQRPQVTM
Sbjct: 1   MFPPSGSTGLIPPSHFQARPLSTLPRMAPTWLSDIPLVQPPGHQDVSERRLDTQRPQVTM 60

Query: 150 WERDVSSDRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKM 209
           WERDVSSDRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKM
Sbjct: 61  WERDVSSDRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKM 120

Query: 210 RLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLHQEQLS 269
           RLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLHQEQLS
Sbjct: 121 RLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLHQEQLS 180

Query: 270 SLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQREAELLRKQLSKTQEDLE 329
           SLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQREAELLRKQLSKTQEDLE
Sbjct: 181 SLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQREAELLRKQLSKTQEDLE 240

Query: 330 AQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQS 389
           AQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQS
Sbjct: 241 AQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQS 300

Query: 390 LTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVK 449
           LTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVK
Sbjct: 301 LTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVK 360

Query: 450 QLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQ 509
           QLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQ
Sbjct: 361 QLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQ 420

Query: 510 QTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIAR 569
           QTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIAR
Sbjct: 421 QTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIAR 480

Query: 570 KLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAE 629
           KLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAE
Sbjct: 481 KLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAE 540

Query: 630 RQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQA 689
           RQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQA
Sbjct: 541 RQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQA 600

Query: 690 LQEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEE 749
           LQEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEE
Sbjct: 601 LQEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEE 660

Query: 750 ARKEEGQRLARRLQELERDKNLMLATLQQEGLLSRYKQQRLLTVLPSLLDKKKSVVSSPR 809
           ARKEEGQRLARRLQELERDKNLMLATLQQEGLLSRYKQQRLLTVLPSLLDKKKSVVSSPR
Sbjct: 661 ARKEEGQRLARRLQELERDKNLMLATLQQEGLLSRYKQQRLLTVLPSLLDKKKSVVSSPR 720

Query: 810 PPECSASAPVAAAVPTRESIKGSLSVLLDDLQDLSEAISKEEAVCQGDNLDRCSSSNPQM 869
           PPECSASAPVAAAVPTRESIKGSLSVLLDDLQDLSEAISKEEAVCQGDNLDRCSSSNPQM
Sbjct: 721 PPECSASAPVAAAVPTRESIKGSLSVLLDDLQDLSEAISKEEAVCQGDNLDRCSSSNPQM 780

Query: 870 SS 871
           SS
Sbjct: 781 SS 782


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score =  119 bits (297), Expect = 2e-26
 Identities = 173/680 (25%), Positives = 283/680 (41%), Gaps = 92/680 (13%)

Query: 178  QQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRA 237
            +QAE+   + ++L   EE  R   E  +Q+ +  E +A      AR  KA   E E L+A
Sbjct: 1963 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA------ARQRKAALEEVERLKA 2016

Query: 238  ALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLE 297
             +  A  +R+  E+ S R+L+  Q   Q++L +  +AH  A+     + +   +   S+ 
Sbjct: 2017 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2076

Query: 298  TRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWEL 357
             +  GEA+    A  EAE  R Q  +       QV   E L++   EQ  +   +Q    
Sbjct: 2077 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ---- 2132

Query: 358  ERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTR 417
                                A AE L+   +      A  E+   R+ Q +D+ E E  +
Sbjct: 2133 --------------------AAAEKLRKEAEQEAARRAQAEQAALRQKQAADA-EMEKHK 2171

Query: 418  KCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQE--QAILQRS 475
            K      R + +V   +  L+ Q LE +D  K L      L E++     E  +A  QRS
Sbjct: 2172 KFAEQTLRQKAQVEQELTTLRLQ-LEETDHQKNL------LDEELQRLKAEATEAARQRS 2224

Query: 476  LQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETT 535
                  +VE E    +    ELS+          +     E   L++    ++Q +L+  
Sbjct: 2225 ------QVEEELFSVRVQMEELSKL---------KARIEAENRALILRDKDNTQRFLQEE 2269

Query: 536  MAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQ 595
              K++  A +      RLS A ++   +R L    LA  +   E          +  E  
Sbjct: 2270 AEKMKQVAEEAA----RLSVAAQEAARLRQLAEEDLAQQRALAEK---------MLKEKM 2316

Query: 596  QLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLG 655
            Q  +E  RL AE    A L+QQ+   A+EQ    ++   ++AQQL +E Q  Q +     
Sbjct: 2317 QAVQEATRLKAE----AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT----- 2367

Query: 656  LQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEA 715
              LE  RQ Q E + EA  L+  + +      QA  E+ A+   +  E++ +   R   A
Sbjct: 2368 --LEAERQRQLEMSAEAERLKLRVAEMSR--AQARAEEDAQRFRKQAEEIGEKLHRTELA 2423

Query: 716  RREHAKAVVSLRQIQRRAAQEKERSQE-LRRLQEEARKEEGQRLARRLQELERDKNLMLA 774
             +E    V +L   ++++  + ER +E +  L+ E  KE+ Q+ A+ LQ     K+  + 
Sbjct: 2424 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE--KEKLQQEAKLLQL----KSEEMQ 2477

Query: 775  TLQQEGLLSRYK--QQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGS 832
            T+QQE LL   +  QQ  L+   SLL +++ +       E      VA A   RE  +  
Sbjct: 2478 TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ 2537

Query: 833  LSVLLDDLQDLSEAISKEEA 852
               +  + Q L    S EEA
Sbjct: 2538 QQQMEQERQRL--VASMEEA 2555



 Score =  114 bits (284), Expect = 5e-25
 Identities = 166/684 (24%), Positives = 295/684 (43%), Gaps = 88/684 (12%)

Query: 160  EPGRRGRSWGLEGSQALSQQAEVIVRQLQELR------RLEEEVRLL---------RETS 204
            E G + R    E    L ++A    ++ QEL       R E EV L          R TS
Sbjct: 1723 EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1782

Query: 205  LQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLH 264
             + K RLEA+A     LA        EA  LRA    A+  R+  EE + R+  E +R+ 
Sbjct: 1783 EKSKQRLEAEAGRFRELAE-------EAARLRALAEEAKRQRQLAEEDAARQRAEAERVL 1835

Query: 265  QEQLSSL---TQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAE--AQREAELLRK 319
             E+L+++   T+   EA  +L  K E   + L  L    A + + L E  AQ +A++  +
Sbjct: 1836 AEKLAAIGEATRLKTEAEIALKEK-EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1894

Query: 320  --QLSKTQE-DLEAQVTLVENL---RKYVGEQV----PSEVHSQTWELERQKLLETMQHL 369
              QL K  + +LE Q  LVE+    R+ V E++     S   +   + E +  L  ++  
Sbjct: 1895 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1954

Query: 370  QEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREK 429
             ED       AEL   R + L      +  E   +VQ S + E E  R+ ++ L      
Sbjct: 1955 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL 2014

Query: 430  VFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQ--------SQEQAILQRSLQDKAA 481
               +    + +E    +S +QL+    + Q+++ ++         Q++  LQ++LQ + +
Sbjct: 2015 KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2074

Query: 482  EVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEG 541
             ++  R  A+  +     A+EAR + +++ A +  Q+        S++   E   A+ + 
Sbjct: 2075 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE---EQAQARAQA 2131

Query: 542  AAAQLPSLNNRLSYAVRKVHTIRGLIARKLA-----------LAQLRQESCPLPPPVTDV 590
             AA           A R+    +  + +K A             Q  ++   +   +T +
Sbjct: 2132 QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL 2191

Query: 591  SLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAE-------RQQLSKVAQQLEQE 643
             L+L++   ++N LD ELQ   +    E  R R Q E E        ++LSK+  ++E E
Sbjct: 2192 RLQLEETDHQKNLLDEELQ-RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE 2250

Query: 644  -----LQQTQESLASLGLQLEVARQGQQE------STEEAASLRQ----ELTQQQELYGQ 688
                 L+    +   L  + E  +Q  +E      + +EAA LRQ    +L QQ+ L  +
Sbjct: 2251 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEK 2310

Query: 689  ALQEKVAEVE--TRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEK---ERSQEL 743
             L+EK+  V+  TRL+ +    +++   A+ +  +      Q+ ++ A+E    +R+ E 
Sbjct: 2311 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2370

Query: 744  RRLQEEARKEEGQRLARRLQELER 767
             R ++     E +RL  R+ E+ R
Sbjct: 2371 ERQRQLEMSAEAERLKLRVAEMSR 2394



 Score =  112 bits (281), Expect = 1e-24
 Identities = 166/662 (25%), Positives = 275/662 (41%), Gaps = 152/662 (22%)

Query: 188  QELRRLEEEVRLLRETSLQQKMRL-------EAQAMELEALARAEKAGRAEAEGLRAALA 240
            + LRR+EEE RL  +   +++ RL       E Q    EA A+A+     EA+ L+  + 
Sbjct: 1339 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1398

Query: 241  GAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKS-------- 292
              EVVR+   E +  + ++ +R  QE+L  L Q+ E  + +   +AE  E+S        
Sbjct: 1399 -EEVVRR---EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1454

Query: 293  ------LSSLETRRAGEAKELA--------------EAQREAELLRKQLS-KTQEDLEAQ 331
                  L + E +R G   EL               +AQ EAE LR+Q+  ++Q   +A+
Sbjct: 1455 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1514

Query: 332  VTLVENLR--------KYVGEQVPSEVHSQTWELER-------------QKLLETMQH-- 368
            V L   ++        K    Q   E+  Q  E ER             Q  LET Q   
Sbjct: 1515 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSA 1574

Query: 369  ---LQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNR 425
               LQ  R S       L+  +Q     +A   EE  R+ Q     E     + +  L R
Sbjct: 1575 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE-RAREEAERELER 1633

Query: 426  WREKVF-ALMVQLKAQELEHSDSVKQLKGQV----ASLQEKVTSQSQEQAILQRSLQDKA 480
            W+ K   AL ++L+A+E+    S+ Q + +     A  + +   +++EQA+ QR L ++ 
Sbjct: 1634 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ- 1692

Query: 481  AEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVE 540
             E+E +R  A+G   +   A++   R + +T   E+Q +L           LE  +A+++
Sbjct: 1693 -ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL-----------LEEELARLQ 1740

Query: 541  GAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREE 600
              AA        L                +  LA++R E         +V L  +   EE
Sbjct: 1741 REAAAATQKRQEL----------------EAELAKVRAEM--------EVLLASKARAEE 1776

Query: 601  RNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEV 660
             +R  +E   S + ++ E GR RE  E E  +L  +A++ +++ Q  +E  A        
Sbjct: 1777 ESRSTSEK--SKQRLEAEAGRFRELAE-EAARLRALAEEAKRQRQLAEEDAA-------- 1825

Query: 661  ARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHA 720
                      + A   + L ++    G+A + K  E E  L+E+ ++ ER     RR   
Sbjct: 1826 ---------RQRAEAERVLAEKLAAIGEATRLKT-EAEIALKEKEAENER----LRRLAE 1871

Query: 721  KAVVSLRQIQRRAAQEK----ERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATL 776
                  R+++ +AAQ K    ER  +LR+  +               ELER K L+  TL
Sbjct: 1872 DEAFQRRRLEEQAAQHKADIEERLAQLRKASD--------------SELERQKGLVEDTL 1917

Query: 777  QQ 778
            +Q
Sbjct: 1918 RQ 1919



 Score =  102 bits (254), Expect = 2e-21
 Identities = 178/740 (24%), Positives = 321/740 (43%), Gaps = 84/740 (11%)

Query: 131  GHQDVSERRLDTQRPQVTMWERDVSSDRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQEL 190
            G Q+V ER       Q    ERDV  +R    R   +  LE  QA+  Q +V  R+L++L
Sbjct: 1155 GAQEVGERL------QQRHGERDVEVERW---RERVAQLLERWQAVLAQTDVRQRELEQL 1205

Query: 191  RRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAA-LAGAEVVRKNL 249
             R   ++R  RE++              + L    +  R   E ++A  LA ++ VR+ L
Sbjct: 1206 GR---QLRYYRESA--------------DPLGAWLQDARRRQEQIQAMPLADSQAVREQL 1248

Query: 250  EEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAE 309
             +  Q  LEE++R H E++    +  ++ ++++      L    + LE   A  AK+  +
Sbjct: 1249 RQ-EQALLEEIER-HGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV-ASPAKK-PK 1304

Query: 310  AQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQHL 369
             Q  +E + ++    +       TL     K++ E +      +   L  Q+  E  + L
Sbjct: 1305 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE--RLAEQQRAEERERL 1362

Query: 370  QEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREK 429
             E   +L    +L +   Q+       Q E   +++Q    ++ E  R+ ++ ++  ++K
Sbjct: 1363 AEVEAALEKQRQLAEAHAQAKA-----QAEREAKELQ--QRMQEEVVRREEAAVDAQQQK 1415

Query: 430  VFALMVQLKAQELEHSDSVK-QLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERM 488
                 +Q + Q+L  S   + Q K + A   E+   + +E+  + R LQ +A E +  R 
Sbjct: 1416 ---RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR-LQLEATERQ--RG 1469

Query: 489  GAKG-LQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLP 547
            GA+G LQ   +RA+EA  + +Q    AE +LR  V   S  +   E  +A    A A+  
Sbjct: 1470 GAEGELQALRARAEEAEAQKRQAQEEAE-RLRRQVQDESQRKRQAEVELASRVKAEAEAA 1528

Query: 548  SLNNRLSYAVRKVHTIRGLIARKLALAQL---RQESCPLPPPVTDVSLELQQLREERNRL 604
                R   A+ ++        R+L  A++   RQ    L         ELQ  R      
Sbjct: 1529 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1588

Query: 605  DAELQLSARLIQQEVGRAREQGEAERQQ---LSKVAQQLEQELQQTQ-ESLASLGLQLEV 660
             A+L+ S +     V + RE+ E   QQ     +  ++ E+EL++ Q ++  +L L+L+ 
Sbjct: 1589 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1648

Query: 661  ARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHA 720
                QQ+S  +A + +Q+   ++E   +   E+ A  +  L EQ  + +R+L E   +  
Sbjct: 1649 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ-- 1706

Query: 721  KAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEG 780
                     QR AA+     QEL RL+ E  + E QR     Q LE +    LA LQ+E 
Sbjct: 1707 ---------QRLAAE-----QELIRLRAETEQGEQQR-----QLLEEE----LARLQREA 1743

Query: 781  LLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGSLSVLLDD- 839
              +  K+Q L   L  +  + + +++S    E  + +    +    E+  G    L ++ 
Sbjct: 1744 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1803

Query: 840  --LQDLSEAISKEEAVCQGD 857
              L+ L+E   ++  + + D
Sbjct: 1804 ARLRALAEEAKRQRQLAEED 1823



 Score = 94.4 bits (233), Expect = 4e-19
 Identities = 150/642 (23%), Positives = 262/642 (40%), Gaps = 78/642 (12%)

Query: 188  QELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRK 247
            Q  R++EE  RL +    Q + R +AQA        AEK  R EAE   A  A AE    
Sbjct: 2106 QSRRQVEEAERLKQSAEEQAQARAQAQAA-------AEKL-RKEAEQEAARRAQAEQAAL 2157

Query: 248  NLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKEL 307
              ++ +  E+E+ ++  ++ L    Q  +E L++L  + E  +   + L+       +EL
Sbjct: 2158 RQKQAADAEMEKHKKFAEQTLRQKAQVEQE-LTTLRLQLEETDHQKNLLD-------EEL 2209

Query: 308  AEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQ 367
               + EA    +Q S+ +E+L +    +E L K     + + + ++   L  +    T +
Sbjct: 2210 QRLKAEATEAARQRSQVEEELFSVRVQMEELSK-----LKARIEAENRALILRDKDNTQR 2264

Query: 368  HLQEDRDSLHATAE---LLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLN 424
             LQE+ + +   AE    L V  Q    +  L EE+L ++   ++ +  E   K Q++  
Sbjct: 2265 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE---KMQAVQE 2321

Query: 425  RWREKVFA-LMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQ-DKAAE 482
              R K  A L+ Q K    E +  +++ K Q+A    + T   Q     +R  Q + +AE
Sbjct: 2322 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE 2381

Query: 483  VEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLET-------- 534
             E  ++    +    +RA+E  +R+++Q     E+L     A       ++T        
Sbjct: 2382 AERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2441

Query: 535  ---------TMAKVEGAAAQLPSLNNRLSYAVRKVHTIR-------------GLIARKLA 572
                      +A++E    +L      L     ++ T++               ++ K +
Sbjct: 2442 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDS 2501

Query: 573  LAQ----LRQESCPLPPPVTDVSLELQQLREERNRLDAEL-QLSARLIQQEVGRAREQGE 627
            L Q    + QE   L     D   + QQLREE+ R   ++ Q   RL+       R Q E
Sbjct: 2502 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2561

Query: 628  AER---------QQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQE 678
            AE          QQL +  +Q E+ L +  + L      LE   +     +EE  + +  
Sbjct: 2562 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2621

Query: 679  LTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKE 738
             T+       AL    AE E    E   D  RR   A+R     ++S  ++Q R AQ   
Sbjct: 2622 ATKTLPNGRDALDGPAAEAEP---EHSFDGLRRKVSAQRLQEAGILSAEELQ-RLAQGHT 2677

Query: 739  RSQELRRLQEEARKEEGQ-RLARRLQELERDKNLMLATLQQE 779
               EL R ++     +G+  +A  L +   +K  + A LQ++
Sbjct: 2678 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQ 2719



 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 148/636 (23%), Positives = 251/636 (39%), Gaps = 123/636 (19%)

Query: 195  EEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEG-------LRAALAGAEVVRK 247
            EEV    E  L++   + A   ELEA   + K  RA+AE        LR  L GA+ V +
Sbjct: 1102 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1161

Query: 248  NLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSL----------- 296
             L++       EV+R  +E+++ L +  +  L+    +   LE+    L           
Sbjct: 1162 RLQQRHGERDVEVERW-RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG 1220

Query: 297  ----ETRRAGE---AKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPS- 348
                + RR  E   A  LA++Q   E LR++ +  +E +E     VE  +++  + + + 
Sbjct: 1221 AWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE-IERHGEKVEECQRFAKQYINAI 1279

Query: 349  ---EVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVR-------------VQSLTH 392
               E+   T++ + + +    +  +    S     E + +R             ++ ++ 
Sbjct: 1280 KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE 1339

Query: 393  ILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQ-ELEHSDSVKQL 451
             L   EEE  R  +   + E E   + ++ L + R+   A   Q KAQ E E  +  +++
Sbjct: 1340 TLRRMEEE-ERLAEQQRAEERERLAEVEAALEKQRQLAEA-HAQAKAQAEREAKELQQRM 1397

Query: 452  KGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQT 511
            + +V   +E      Q++  +Q  LQ      E E + AK  Q E +     R       
Sbjct: 1398 QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE-IQAKARQAEAAERSRLR------- 1449

Query: 512  ASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKL 571
               EE++R+V       ++ LE T  +  GA  +L +L  R   A               
Sbjct: 1450 --IEEEIRVV-------RLQLEATERQRGGAEGELQALRARAEEA--------------- 1485

Query: 572  ALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAERQ 631
                                 + +Q +EE  RL        R +Q E  R R Q E E  
Sbjct: 1486 -------------------EAQKRQAQEEAERL-------RRQVQDESQRKR-QAEVELA 1518

Query: 632  QLSKVAQQLEQELQQTQESLASLGLQLEVA-RQGQQESTEEAASLRQELTQQQELYGQAL 690
               K   +  +E Q+  ++L  L LQ E A R+ +Q   E A  ++  L   Q      L
Sbjct: 1519 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAEL 1578

Query: 691  QEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQE-------KERSQEL 743
            Q K A       E+ +  ER L E   EH        + +RRA Q+       +E  +EL
Sbjct: 1579 QSKRAS----FAEKTAQLERSLQE---EHVAVAQLREEAERRAQQQAEAERAREEAEREL 1631

Query: 744  RRLQEEARKEEGQRLARRLQELERDKNLMLATLQQE 779
             R Q +A   E  RL  + +E+ + K+L  A  +++
Sbjct: 1632 ERWQLKA--NEALRLRLQAEEVAQQKSLAQAEAEKQ 1665


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score =  119 bits (297), Expect = 2e-26
 Identities = 173/680 (25%), Positives = 283/680 (41%), Gaps = 92/680 (13%)

Query: 178  QQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRA 237
            +QAE+   + ++L   EE  R   E  +Q+ +  E +A      AR  KA   E E L+A
Sbjct: 1967 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA------ARQRKAALEEVERLKA 2020

Query: 238  ALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLE 297
             +  A  +R+  E+ S R+L+  Q   Q++L +  +AH  A+     + +   +   S+ 
Sbjct: 2021 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2080

Query: 298  TRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWEL 357
             +  GEA+    A  EAE  R Q  +       QV   E L++   EQ  +   +Q    
Sbjct: 2081 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ---- 2136

Query: 358  ERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTR 417
                                A AE L+   +      A  E+   R+ Q +D+ E E  +
Sbjct: 2137 --------------------AAAEKLRKEAEQEAARRAQAEQAALRQKQAADA-EMEKHK 2175

Query: 418  KCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQE--QAILQRS 475
            K      R + +V   +  L+ Q LE +D  K L      L E++     E  +A  QRS
Sbjct: 2176 KFAEQTLRQKAQVEQELTTLRLQ-LEETDHQKNL------LDEELQRLKAEATEAARQRS 2228

Query: 476  LQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETT 535
                  +VE E    +    ELS+          +     E   L++    ++Q +L+  
Sbjct: 2229 ------QVEEELFSVRVQMEELSKL---------KARIEAENRALILRDKDNTQRFLQEE 2273

Query: 536  MAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQ 595
              K++  A +      RLS A ++   +R L    LA  +   E          +  E  
Sbjct: 2274 AEKMKQVAEEAA----RLSVAAQEAARLRQLAEEDLAQQRALAEK---------MLKEKM 2320

Query: 596  QLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLG 655
            Q  +E  RL AE    A L+QQ+   A+EQ    ++   ++AQQL +E Q  Q +     
Sbjct: 2321 QAVQEATRLKAE----AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT----- 2371

Query: 656  LQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEA 715
              LE  RQ Q E + EA  L+  + +      QA  E+ A+   +  E++ +   R   A
Sbjct: 2372 --LEAERQRQLEMSAEAERLKLRVAEMSR--AQARAEEDAQRFRKQAEEIGEKLHRTELA 2427

Query: 716  RREHAKAVVSLRQIQRRAAQEKERSQE-LRRLQEEARKEEGQRLARRLQELERDKNLMLA 774
             +E    V +L   ++++  + ER +E +  L+ E  KE+ Q+ A+ LQ     K+  + 
Sbjct: 2428 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE--KEKLQQEAKLLQL----KSEEMQ 2481

Query: 775  TLQQEGLLSRYK--QQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGS 832
            T+QQE LL   +  QQ  L+   SLL +++ +       E      VA A   RE  +  
Sbjct: 2482 TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ 2541

Query: 833  LSVLLDDLQDLSEAISKEEA 852
               +  + Q L    S EEA
Sbjct: 2542 QQQMEQERQRL--VASMEEA 2559



 Score =  114 bits (284), Expect = 5e-25
 Identities = 166/684 (24%), Positives = 295/684 (43%), Gaps = 88/684 (12%)

Query: 160  EPGRRGRSWGLEGSQALSQQAEVIVRQLQELR------RLEEEVRLL---------RETS 204
            E G + R    E    L ++A    ++ QEL       R E EV L          R TS
Sbjct: 1727 EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1786

Query: 205  LQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLH 264
             + K RLEA+A     LA        EA  LRA    A+  R+  EE + R+  E +R+ 
Sbjct: 1787 EKSKQRLEAEAGRFRELAE-------EAARLRALAEEAKRQRQLAEEDAARQRAEAERVL 1839

Query: 265  QEQLSSL---TQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAE--AQREAELLRK 319
             E+L+++   T+   EA  +L  K E   + L  L    A + + L E  AQ +A++  +
Sbjct: 1840 AEKLAAIGEATRLKTEAEIALKEK-EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1898

Query: 320  --QLSKTQE-DLEAQVTLVENL---RKYVGEQV----PSEVHSQTWELERQKLLETMQHL 369
              QL K  + +LE Q  LVE+    R+ V E++     S   +   + E +  L  ++  
Sbjct: 1899 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1958

Query: 370  QEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREK 429
             ED       AEL   R + L      +  E   +VQ S + E E  R+ ++ L      
Sbjct: 1959 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL 2018

Query: 430  VFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQ--------SQEQAILQRSLQDKAA 481
               +    + +E    +S +QL+    + Q+++ ++         Q++  LQ++LQ + +
Sbjct: 2019 KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2078

Query: 482  EVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEG 541
             ++  R  A+  +     A+EAR + +++ A +  Q+        S++   E   A+ + 
Sbjct: 2079 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE---EQAQARAQA 2135

Query: 542  AAAQLPSLNNRLSYAVRKVHTIRGLIARKLA-----------LAQLRQESCPLPPPVTDV 590
             AA           A R+    +  + +K A             Q  ++   +   +T +
Sbjct: 2136 QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL 2195

Query: 591  SLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAE-------RQQLSKVAQQLEQE 643
             L+L++   ++N LD ELQ   +    E  R R Q E E        ++LSK+  ++E E
Sbjct: 2196 RLQLEETDHQKNLLDEELQ-RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE 2254

Query: 644  -----LQQTQESLASLGLQLEVARQGQQE------STEEAASLRQ----ELTQQQELYGQ 688
                 L+    +   L  + E  +Q  +E      + +EAA LRQ    +L QQ+ L  +
Sbjct: 2255 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEK 2314

Query: 689  ALQEKVAEVE--TRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEK---ERSQEL 743
             L+EK+  V+  TRL+ +    +++   A+ +  +      Q+ ++ A+E    +R+ E 
Sbjct: 2315 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2374

Query: 744  RRLQEEARKEEGQRLARRLQELER 767
             R ++     E +RL  R+ E+ R
Sbjct: 2375 ERQRQLEMSAEAERLKLRVAEMSR 2398



 Score =  112 bits (281), Expect = 1e-24
 Identities = 166/662 (25%), Positives = 275/662 (41%), Gaps = 152/662 (22%)

Query: 188  QELRRLEEEVRLLRETSLQQKMRL-------EAQAMELEALARAEKAGRAEAEGLRAALA 240
            + LRR+EEE RL  +   +++ RL       E Q    EA A+A+     EA+ L+  + 
Sbjct: 1343 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1402

Query: 241  GAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKS-------- 292
              EVVR+   E +  + ++ +R  QE+L  L Q+ E  + +   +AE  E+S        
Sbjct: 1403 -EEVVRR---EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1458

Query: 293  ------LSSLETRRAGEAKELA--------------EAQREAELLRKQLS-KTQEDLEAQ 331
                  L + E +R G   EL               +AQ EAE LR+Q+  ++Q   +A+
Sbjct: 1459 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1518

Query: 332  VTLVENLR--------KYVGEQVPSEVHSQTWELER-------------QKLLETMQH-- 368
            V L   ++        K    Q   E+  Q  E ER             Q  LET Q   
Sbjct: 1519 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSA 1578

Query: 369  ---LQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNR 425
               LQ  R S       L+  +Q     +A   EE  R+ Q     E     + +  L R
Sbjct: 1579 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE-RAREEAERELER 1637

Query: 426  WREKVF-ALMVQLKAQELEHSDSVKQLKGQV----ASLQEKVTSQSQEQAILQRSLQDKA 480
            W+ K   AL ++L+A+E+    S+ Q + +     A  + +   +++EQA+ QR L ++ 
Sbjct: 1638 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ- 1696

Query: 481  AEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVE 540
             E+E +R  A+G   +   A++   R + +T   E+Q +L           LE  +A+++
Sbjct: 1697 -ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL-----------LEEELARLQ 1744

Query: 541  GAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREE 600
              AA        L                +  LA++R E         +V L  +   EE
Sbjct: 1745 REAAAATQKRQEL----------------EAELAKVRAEM--------EVLLASKARAEE 1780

Query: 601  RNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEV 660
             +R  +E   S + ++ E GR RE  E E  +L  +A++ +++ Q  +E  A        
Sbjct: 1781 ESRSTSEK--SKQRLEAEAGRFRELAE-EAARLRALAEEAKRQRQLAEEDAA-------- 1829

Query: 661  ARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHA 720
                      + A   + L ++    G+A + K  E E  L+E+ ++ ER     RR   
Sbjct: 1830 ---------RQRAEAERVLAEKLAAIGEATRLKT-EAEIALKEKEAENER----LRRLAE 1875

Query: 721  KAVVSLRQIQRRAAQEK----ERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATL 776
                  R+++ +AAQ K    ER  +LR+  +               ELER K L+  TL
Sbjct: 1876 DEAFQRRRLEEQAAQHKADIEERLAQLRKASD--------------SELERQKGLVEDTL 1921

Query: 777  QQ 778
            +Q
Sbjct: 1922 RQ 1923



 Score =  102 bits (254), Expect = 2e-21
 Identities = 178/740 (24%), Positives = 321/740 (43%), Gaps = 84/740 (11%)

Query: 131  GHQDVSERRLDTQRPQVTMWERDVSSDRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQEL 190
            G Q+V ER       Q    ERDV  +R    R   +  LE  QA+  Q +V  R+L++L
Sbjct: 1159 GAQEVGERL------QQRHGERDVEVERW---RERVAQLLERWQAVLAQTDVRQRELEQL 1209

Query: 191  RRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAA-LAGAEVVRKNL 249
             R   ++R  RE++              + L    +  R   E ++A  LA ++ VR+ L
Sbjct: 1210 GR---QLRYYRESA--------------DPLGAWLQDARRRQEQIQAMPLADSQAVREQL 1252

Query: 250  EEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAE 309
             +  Q  LEE++R H E++    +  ++ ++++      L    + LE   A  AK+  +
Sbjct: 1253 RQ-EQALLEEIER-HGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV-ASPAKK-PK 1308

Query: 310  AQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQHL 369
             Q  +E + ++    +       TL     K++ E +      +   L  Q+  E  + L
Sbjct: 1309 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE--RLAEQQRAEERERL 1366

Query: 370  QEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREK 429
             E   +L    +L +   Q+       Q E   +++Q    ++ E  R+ ++ ++  ++K
Sbjct: 1367 AEVEAALEKQRQLAEAHAQAKA-----QAEREAKELQ--QRMQEEVVRREEAAVDAQQQK 1419

Query: 430  VFALMVQLKAQELEHSDSVK-QLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERM 488
                 +Q + Q+L  S   + Q K + A   E+   + +E+  + R LQ +A E +  R 
Sbjct: 1420 ---RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR-LQLEATERQ--RG 1473

Query: 489  GAKG-LQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLP 547
            GA+G LQ   +RA+EA  + +Q    AE +LR  V   S  +   E  +A    A A+  
Sbjct: 1474 GAEGELQALRARAEEAEAQKRQAQEEAE-RLRRQVQDESQRKRQAEVELASRVKAEAEAA 1532

Query: 548  SLNNRLSYAVRKVHTIRGLIARKLALAQL---RQESCPLPPPVTDVSLELQQLREERNRL 604
                R   A+ ++        R+L  A++   RQ    L         ELQ  R      
Sbjct: 1533 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1592

Query: 605  DAELQLSARLIQQEVGRAREQGEAERQQ---LSKVAQQLEQELQQTQ-ESLASLGLQLEV 660
             A+L+ S +     V + RE+ E   QQ     +  ++ E+EL++ Q ++  +L L+L+ 
Sbjct: 1593 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1652

Query: 661  ARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHA 720
                QQ+S  +A + +Q+   ++E   +   E+ A  +  L EQ  + +R+L E   +  
Sbjct: 1653 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ-- 1710

Query: 721  KAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEG 780
                     QR AA+     QEL RL+ E  + E QR     Q LE +    LA LQ+E 
Sbjct: 1711 ---------QRLAAE-----QELIRLRAETEQGEQQR-----QLLEEE----LARLQREA 1747

Query: 781  LLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGSLSVLLDD- 839
              +  K+Q L   L  +  + + +++S    E  + +    +    E+  G    L ++ 
Sbjct: 1748 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1807

Query: 840  --LQDLSEAISKEEAVCQGD 857
              L+ L+E   ++  + + D
Sbjct: 1808 ARLRALAEEAKRQRQLAEED 1827



 Score = 94.4 bits (233), Expect = 4e-19
 Identities = 150/642 (23%), Positives = 262/642 (40%), Gaps = 78/642 (12%)

Query: 188  QELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRK 247
            Q  R++EE  RL +    Q + R +AQA        AEK  R EAE   A  A AE    
Sbjct: 2110 QSRRQVEEAERLKQSAEEQAQARAQAQAA-------AEKL-RKEAEQEAARRAQAEQAAL 2161

Query: 248  NLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKEL 307
              ++ +  E+E+ ++  ++ L    Q  +E L++L  + E  +   + L+       +EL
Sbjct: 2162 RQKQAADAEMEKHKKFAEQTLRQKAQVEQE-LTTLRLQLEETDHQKNLLD-------EEL 2213

Query: 308  AEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQ 367
               + EA    +Q S+ +E+L +    +E L K     + + + ++   L  +    T +
Sbjct: 2214 QRLKAEATEAARQRSQVEEELFSVRVQMEELSK-----LKARIEAENRALILRDKDNTQR 2268

Query: 368  HLQEDRDSLHATAE---LLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLN 424
             LQE+ + +   AE    L V  Q    +  L EE+L ++   ++ +  E   K Q++  
Sbjct: 2269 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE---KMQAVQE 2325

Query: 425  RWREKVFA-LMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQ-DKAAE 482
              R K  A L+ Q K    E +  +++ K Q+A    + T   Q     +R  Q + +AE
Sbjct: 2326 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE 2385

Query: 483  VEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLET-------- 534
             E  ++    +    +RA+E  +R+++Q     E+L     A       ++T        
Sbjct: 2386 AERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2445

Query: 535  ---------TMAKVEGAAAQLPSLNNRLSYAVRKVHTIR-------------GLIARKLA 572
                      +A++E    +L      L     ++ T++               ++ K +
Sbjct: 2446 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDS 2505

Query: 573  LAQ----LRQESCPLPPPVTDVSLELQQLREERNRLDAEL-QLSARLIQQEVGRAREQGE 627
            L Q    + QE   L     D   + QQLREE+ R   ++ Q   RL+       R Q E
Sbjct: 2506 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2565

Query: 628  AER---------QQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQE 678
            AE          QQL +  +Q E+ L +  + L      LE   +     +EE  + +  
Sbjct: 2566 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2625

Query: 679  LTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKE 738
             T+       AL    AE E    E   D  RR   A+R     ++S  ++Q R AQ   
Sbjct: 2626 ATKTLPNGRDALDGPAAEAEP---EHSFDGLRRKVSAQRLQEAGILSAEELQ-RLAQGHT 2681

Query: 739  RSQELRRLQEEARKEEGQ-RLARRLQELERDKNLMLATLQQE 779
               EL R ++     +G+  +A  L +   +K  + A LQ++
Sbjct: 2682 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQ 2723



 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 148/636 (23%), Positives = 251/636 (39%), Gaps = 123/636 (19%)

Query: 195  EEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEG-------LRAALAGAEVVRK 247
            EEV    E  L++   + A   ELEA   + K  RA+AE        LR  L GA+ V +
Sbjct: 1106 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1165

Query: 248  NLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSL----------- 296
             L++       EV+R  +E+++ L +  +  L+    +   LE+    L           
Sbjct: 1166 RLQQRHGERDVEVERW-RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG 1224

Query: 297  ----ETRRAGE---AKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPS- 348
                + RR  E   A  LA++Q   E LR++ +  +E +E     VE  +++  + + + 
Sbjct: 1225 AWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE-IERHGEKVEECQRFAKQYINAI 1283

Query: 349  ---EVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVR-------------VQSLTH 392
               E+   T++ + + +    +  +    S     E + +R             ++ ++ 
Sbjct: 1284 KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE 1343

Query: 393  ILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQ-ELEHSDSVKQL 451
             L   EEE  R  +   + E E   + ++ L + R+   A   Q KAQ E E  +  +++
Sbjct: 1344 TLRRMEEE-ERLAEQQRAEERERLAEVEAALEKQRQLAEA-HAQAKAQAEREAKELQQRM 1401

Query: 452  KGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQT 511
            + +V   +E      Q++  +Q  LQ      E E + AK  Q E +     R       
Sbjct: 1402 QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE-IQAKARQAEAAERSRLR------- 1453

Query: 512  ASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKL 571
               EE++R+V       ++ LE T  +  GA  +L +L  R   A               
Sbjct: 1454 --IEEEIRVV-------RLQLEATERQRGGAEGELQALRARAEEA--------------- 1489

Query: 572  ALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAERQ 631
                                 + +Q +EE  RL        R +Q E  R R Q E E  
Sbjct: 1490 -------------------EAQKRQAQEEAERL-------RRQVQDESQRKR-QAEVELA 1522

Query: 632  QLSKVAQQLEQELQQTQESLASLGLQLEVA-RQGQQESTEEAASLRQELTQQQELYGQAL 690
               K   +  +E Q+  ++L  L LQ E A R+ +Q   E A  ++  L   Q      L
Sbjct: 1523 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAEL 1582

Query: 691  QEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQE-------KERSQEL 743
            Q K A       E+ +  ER L E   EH        + +RRA Q+       +E  +EL
Sbjct: 1583 QSKRAS----FAEKTAQLERSLQE---EHVAVAQLREEAERRAQQQAEAERAREEAEREL 1635

Query: 744  RRLQEEARKEEGQRLARRLQELERDKNLMLATLQQE 779
             R Q +A   E  RL  + +E+ + K+L  A  +++
Sbjct: 1636 ERWQLKA--NEALRLRLQAEEVAQQKSLAQAEAEKQ 1669


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score =  119 bits (297), Expect = 2e-26
 Identities = 173/680 (25%), Positives = 283/680 (41%), Gaps = 92/680 (13%)

Query: 178  QQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRA 237
            +QAE+   + ++L   EE  R   E  +Q+ +  E +A      AR  KA   E E L+A
Sbjct: 1963 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA------ARQRKAALEEVERLKA 2016

Query: 238  ALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLE 297
             +  A  +R+  E+ S R+L+  Q   Q++L +  +AH  A+     + +   +   S+ 
Sbjct: 2017 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2076

Query: 298  TRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWEL 357
             +  GEA+    A  EAE  R Q  +       QV   E L++   EQ  +   +Q    
Sbjct: 2077 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ---- 2132

Query: 358  ERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTR 417
                                A AE L+   +      A  E+   R+ Q +D+ E E  +
Sbjct: 2133 --------------------AAAEKLRKEAEQEAARRAQAEQAALRQKQAADA-EMEKHK 2171

Query: 418  KCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQE--QAILQRS 475
            K      R + +V   +  L+ Q LE +D  K L      L E++     E  +A  QRS
Sbjct: 2172 KFAEQTLRQKAQVEQELTTLRLQ-LEETDHQKNL------LDEELQRLKAEATEAARQRS 2224

Query: 476  LQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETT 535
                  +VE E    +    ELS+          +     E   L++    ++Q +L+  
Sbjct: 2225 ------QVEEELFSVRVQMEELSKL---------KARIEAENRALILRDKDNTQRFLQEE 2269

Query: 536  MAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQ 595
              K++  A +      RLS A ++   +R L    LA  +   E          +  E  
Sbjct: 2270 AEKMKQVAEEAA----RLSVAAQEAARLRQLAEEDLAQQRALAEK---------MLKEKM 2316

Query: 596  QLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLG 655
            Q  +E  RL AE    A L+QQ+   A+EQ    ++   ++AQQL +E Q  Q +     
Sbjct: 2317 QAVQEATRLKAE----AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT----- 2367

Query: 656  LQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEA 715
              LE  RQ Q E + EA  L+  + +      QA  E+ A+   +  E++ +   R   A
Sbjct: 2368 --LEAERQRQLEMSAEAERLKLRVAEMSR--AQARAEEDAQRFRKQAEEIGEKLHRTELA 2423

Query: 716  RREHAKAVVSLRQIQRRAAQEKERSQE-LRRLQEEARKEEGQRLARRLQELERDKNLMLA 774
             +E    V +L   ++++  + ER +E +  L+ E  KE+ Q+ A+ LQ     K+  + 
Sbjct: 2424 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE--KEKLQQEAKLLQL----KSEEMQ 2477

Query: 775  TLQQEGLLSRYK--QQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGS 832
            T+QQE LL   +  QQ  L+   SLL +++ +       E      VA A   RE  +  
Sbjct: 2478 TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ 2537

Query: 833  LSVLLDDLQDLSEAISKEEA 852
               +  + Q L    S EEA
Sbjct: 2538 QQQMEQERQRL--VASMEEA 2555



 Score =  114 bits (284), Expect = 5e-25
 Identities = 166/684 (24%), Positives = 295/684 (43%), Gaps = 88/684 (12%)

Query: 160  EPGRRGRSWGLEGSQALSQQAEVIVRQLQELR------RLEEEVRLL---------RETS 204
            E G + R    E    L ++A    ++ QEL       R E EV L          R TS
Sbjct: 1723 EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1782

Query: 205  LQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLH 264
             + K RLEA+A     LA        EA  LRA    A+  R+  EE + R+  E +R+ 
Sbjct: 1783 EKSKQRLEAEAGRFRELAE-------EAARLRALAEEAKRQRQLAEEDAARQRAEAERVL 1835

Query: 265  QEQLSSL---TQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAE--AQREAELLRK 319
             E+L+++   T+   EA  +L  K E   + L  L    A + + L E  AQ +A++  +
Sbjct: 1836 AEKLAAIGEATRLKTEAEIALKEK-EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1894

Query: 320  --QLSKTQE-DLEAQVTLVENL---RKYVGEQV----PSEVHSQTWELERQKLLETMQHL 369
              QL K  + +LE Q  LVE+    R+ V E++     S   +   + E +  L  ++  
Sbjct: 1895 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1954

Query: 370  QEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREK 429
             ED       AEL   R + L      +  E   +VQ S + E E  R+ ++ L      
Sbjct: 1955 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL 2014

Query: 430  VFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQ--------SQEQAILQRSLQDKAA 481
               +    + +E    +S +QL+    + Q+++ ++         Q++  LQ++LQ + +
Sbjct: 2015 KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2074

Query: 482  EVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEG 541
             ++  R  A+  +     A+EAR + +++ A +  Q+        S++   E   A+ + 
Sbjct: 2075 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE---EQAQARAQA 2131

Query: 542  AAAQLPSLNNRLSYAVRKVHTIRGLIARKLA-----------LAQLRQESCPLPPPVTDV 590
             AA           A R+    +  + +K A             Q  ++   +   +T +
Sbjct: 2132 QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL 2191

Query: 591  SLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAE-------RQQLSKVAQQLEQE 643
             L+L++   ++N LD ELQ   +    E  R R Q E E        ++LSK+  ++E E
Sbjct: 2192 RLQLEETDHQKNLLDEELQ-RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE 2250

Query: 644  -----LQQTQESLASLGLQLEVARQGQQE------STEEAASLRQ----ELTQQQELYGQ 688
                 L+    +   L  + E  +Q  +E      + +EAA LRQ    +L QQ+ L  +
Sbjct: 2251 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEK 2310

Query: 689  ALQEKVAEVE--TRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEK---ERSQEL 743
             L+EK+  V+  TRL+ +    +++   A+ +  +      Q+ ++ A+E    +R+ E 
Sbjct: 2311 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2370

Query: 744  RRLQEEARKEEGQRLARRLQELER 767
             R ++     E +RL  R+ E+ R
Sbjct: 2371 ERQRQLEMSAEAERLKLRVAEMSR 2394



 Score =  112 bits (281), Expect = 1e-24
 Identities = 166/662 (25%), Positives = 275/662 (41%), Gaps = 152/662 (22%)

Query: 188  QELRRLEEEVRLLRETSLQQKMRL-------EAQAMELEALARAEKAGRAEAEGLRAALA 240
            + LRR+EEE RL  +   +++ RL       E Q    EA A+A+     EA+ L+  + 
Sbjct: 1339 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1398

Query: 241  GAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKS-------- 292
              EVVR+   E +  + ++ +R  QE+L  L Q+ E  + +   +AE  E+S        
Sbjct: 1399 -EEVVRR---EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1454

Query: 293  ------LSSLETRRAGEAKELA--------------EAQREAELLRKQLS-KTQEDLEAQ 331
                  L + E +R G   EL               +AQ EAE LR+Q+  ++Q   +A+
Sbjct: 1455 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1514

Query: 332  VTLVENLR--------KYVGEQVPSEVHSQTWELER-------------QKLLETMQH-- 368
            V L   ++        K    Q   E+  Q  E ER             Q  LET Q   
Sbjct: 1515 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSA 1574

Query: 369  ---LQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNR 425
               LQ  R S       L+  +Q     +A   EE  R+ Q     E     + +  L R
Sbjct: 1575 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE-RAREEAERELER 1633

Query: 426  WREKVF-ALMVQLKAQELEHSDSVKQLKGQV----ASLQEKVTSQSQEQAILQRSLQDKA 480
            W+ K   AL ++L+A+E+    S+ Q + +     A  + +   +++EQA+ QR L ++ 
Sbjct: 1634 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ- 1692

Query: 481  AEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVE 540
             E+E +R  A+G   +   A++   R + +T   E+Q +L           LE  +A+++
Sbjct: 1693 -ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL-----------LEEELARLQ 1740

Query: 541  GAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREE 600
              AA        L                +  LA++R E         +V L  +   EE
Sbjct: 1741 REAAAATQKRQEL----------------EAELAKVRAEM--------EVLLASKARAEE 1776

Query: 601  RNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEV 660
             +R  +E   S + ++ E GR RE  E E  +L  +A++ +++ Q  +E  A        
Sbjct: 1777 ESRSTSEK--SKQRLEAEAGRFRELAE-EAARLRALAEEAKRQRQLAEEDAA-------- 1825

Query: 661  ARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHA 720
                      + A   + L ++    G+A + K  E E  L+E+ ++ ER     RR   
Sbjct: 1826 ---------RQRAEAERVLAEKLAAIGEATRLKT-EAEIALKEKEAENER----LRRLAE 1871

Query: 721  KAVVSLRQIQRRAAQEK----ERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATL 776
                  R+++ +AAQ K    ER  +LR+  +               ELER K L+  TL
Sbjct: 1872 DEAFQRRRLEEQAAQHKADIEERLAQLRKASD--------------SELERQKGLVEDTL 1917

Query: 777  QQ 778
            +Q
Sbjct: 1918 RQ 1919



 Score =  102 bits (254), Expect = 2e-21
 Identities = 178/740 (24%), Positives = 321/740 (43%), Gaps = 84/740 (11%)

Query: 131  GHQDVSERRLDTQRPQVTMWERDVSSDRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQEL 190
            G Q+V ER       Q    ERDV  +R    R   +  LE  QA+  Q +V  R+L++L
Sbjct: 1155 GAQEVGERL------QQRHGERDVEVERW---RERVAQLLERWQAVLAQTDVRQRELEQL 1205

Query: 191  RRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAA-LAGAEVVRKNL 249
             R   ++R  RE++              + L    +  R   E ++A  LA ++ VR+ L
Sbjct: 1206 GR---QLRYYRESA--------------DPLGAWLQDARRRQEQIQAMPLADSQAVREQL 1248

Query: 250  EEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAE 309
             +  Q  LEE++R H E++    +  ++ ++++      L    + LE   A  AK+  +
Sbjct: 1249 RQ-EQALLEEIER-HGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV-ASPAKK-PK 1304

Query: 310  AQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQHL 369
             Q  +E + ++    +       TL     K++ E +      +   L  Q+  E  + L
Sbjct: 1305 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE--RLAEQQRAEERERL 1362

Query: 370  QEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREK 429
             E   +L    +L +   Q+       Q E   +++Q    ++ E  R+ ++ ++  ++K
Sbjct: 1363 AEVEAALEKQRQLAEAHAQAKA-----QAEREAKELQ--QRMQEEVVRREEAAVDAQQQK 1415

Query: 430  VFALMVQLKAQELEHSDSVK-QLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERM 488
                 +Q + Q+L  S   + Q K + A   E+   + +E+  + R LQ +A E +  R 
Sbjct: 1416 ---RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR-LQLEATERQ--RG 1469

Query: 489  GAKG-LQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLP 547
            GA+G LQ   +RA+EA  + +Q    AE +LR  V   S  +   E  +A    A A+  
Sbjct: 1470 GAEGELQALRARAEEAEAQKRQAQEEAE-RLRRQVQDESQRKRQAEVELASRVKAEAEAA 1528

Query: 548  SLNNRLSYAVRKVHTIRGLIARKLALAQL---RQESCPLPPPVTDVSLELQQLREERNRL 604
                R   A+ ++        R+L  A++   RQ    L         ELQ  R      
Sbjct: 1529 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1588

Query: 605  DAELQLSARLIQQEVGRAREQGEAERQQ---LSKVAQQLEQELQQTQ-ESLASLGLQLEV 660
             A+L+ S +     V + RE+ E   QQ     +  ++ E+EL++ Q ++  +L L+L+ 
Sbjct: 1589 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1648

Query: 661  ARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHA 720
                QQ+S  +A + +Q+   ++E   +   E+ A  +  L EQ  + +R+L E   +  
Sbjct: 1649 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ-- 1706

Query: 721  KAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEG 780
                     QR AA+     QEL RL+ E  + E QR     Q LE +    LA LQ+E 
Sbjct: 1707 ---------QRLAAE-----QELIRLRAETEQGEQQR-----QLLEEE----LARLQREA 1743

Query: 781  LLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGSLSVLLDD- 839
              +  K+Q L   L  +  + + +++S    E  + +    +    E+  G    L ++ 
Sbjct: 1744 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1803

Query: 840  --LQDLSEAISKEEAVCQGD 857
              L+ L+E   ++  + + D
Sbjct: 1804 ARLRALAEEAKRQRQLAEED 1823



 Score = 94.4 bits (233), Expect = 4e-19
 Identities = 150/642 (23%), Positives = 262/642 (40%), Gaps = 78/642 (12%)

Query: 188  QELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRK 247
            Q  R++EE  RL +    Q + R +AQA        AEK  R EAE   A  A AE    
Sbjct: 2106 QSRRQVEEAERLKQSAEEQAQARAQAQAA-------AEKL-RKEAEQEAARRAQAEQAAL 2157

Query: 248  NLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKEL 307
              ++ +  E+E+ ++  ++ L    Q  +E L++L  + E  +   + L+       +EL
Sbjct: 2158 RQKQAADAEMEKHKKFAEQTLRQKAQVEQE-LTTLRLQLEETDHQKNLLD-------EEL 2209

Query: 308  AEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQ 367
               + EA    +Q S+ +E+L +    +E L K     + + + ++   L  +    T +
Sbjct: 2210 QRLKAEATEAARQRSQVEEELFSVRVQMEELSK-----LKARIEAENRALILRDKDNTQR 2264

Query: 368  HLQEDRDSLHATAE---LLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLN 424
             LQE+ + +   AE    L V  Q    +  L EE+L ++   ++ +  E   K Q++  
Sbjct: 2265 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE---KMQAVQE 2321

Query: 425  RWREKVFA-LMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQ-DKAAE 482
              R K  A L+ Q K    E +  +++ K Q+A    + T   Q     +R  Q + +AE
Sbjct: 2322 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE 2381

Query: 483  VEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLET-------- 534
             E  ++    +    +RA+E  +R+++Q     E+L     A       ++T        
Sbjct: 2382 AERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2441

Query: 535  ---------TMAKVEGAAAQLPSLNNRLSYAVRKVHTIR-------------GLIARKLA 572
                      +A++E    +L      L     ++ T++               ++ K +
Sbjct: 2442 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDS 2501

Query: 573  LAQ----LRQESCPLPPPVTDVSLELQQLREERNRLDAEL-QLSARLIQQEVGRAREQGE 627
            L Q    + QE   L     D   + QQLREE+ R   ++ Q   RL+       R Q E
Sbjct: 2502 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2561

Query: 628  AER---------QQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQE 678
            AE          QQL +  +Q E+ L +  + L      LE   +     +EE  + +  
Sbjct: 2562 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2621

Query: 679  LTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKE 738
             T+       AL    AE E    E   D  RR   A+R     ++S  ++Q R AQ   
Sbjct: 2622 ATKTLPNGRDALDGPAAEAEP---EHSFDGLRRKVSAQRLQEAGILSAEELQ-RLAQGHT 2677

Query: 739  RSQELRRLQEEARKEEGQ-RLARRLQELERDKNLMLATLQQE 779
               EL R ++     +G+  +A  L +   +K  + A LQ++
Sbjct: 2678 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQ 2719



 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 148/636 (23%), Positives = 251/636 (39%), Gaps = 123/636 (19%)

Query: 195  EEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEG-------LRAALAGAEVVRK 247
            EEV    E  L++   + A   ELEA   + K  RA+AE        LR  L GA+ V +
Sbjct: 1102 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1161

Query: 248  NLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSL----------- 296
             L++       EV+R  +E+++ L +  +  L+    +   LE+    L           
Sbjct: 1162 RLQQRHGERDVEVERW-RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG 1220

Query: 297  ----ETRRAGE---AKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPS- 348
                + RR  E   A  LA++Q   E LR++ +  +E +E     VE  +++  + + + 
Sbjct: 1221 AWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE-IERHGEKVEECQRFAKQYINAI 1279

Query: 349  ---EVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVR-------------VQSLTH 392
               E+   T++ + + +    +  +    S     E + +R             ++ ++ 
Sbjct: 1280 KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE 1339

Query: 393  ILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQ-ELEHSDSVKQL 451
             L   EEE  R  +   + E E   + ++ L + R+   A   Q KAQ E E  +  +++
Sbjct: 1340 TLRRMEEE-ERLAEQQRAEERERLAEVEAALEKQRQLAEA-HAQAKAQAEREAKELQQRM 1397

Query: 452  KGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQT 511
            + +V   +E      Q++  +Q  LQ      E E + AK  Q E +     R       
Sbjct: 1398 QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE-IQAKARQAEAAERSRLR------- 1449

Query: 512  ASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKL 571
               EE++R+V       ++ LE T  +  GA  +L +L  R   A               
Sbjct: 1450 --IEEEIRVV-------RLQLEATERQRGGAEGELQALRARAEEA--------------- 1485

Query: 572  ALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAERQ 631
                                 + +Q +EE  RL        R +Q E  R R Q E E  
Sbjct: 1486 -------------------EAQKRQAQEEAERL-------RRQVQDESQRKR-QAEVELA 1518

Query: 632  QLSKVAQQLEQELQQTQESLASLGLQLEVA-RQGQQESTEEAASLRQELTQQQELYGQAL 690
               K   +  +E Q+  ++L  L LQ E A R+ +Q   E A  ++  L   Q      L
Sbjct: 1519 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAEL 1578

Query: 691  QEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQE-------KERSQEL 743
            Q K A       E+ +  ER L E   EH        + +RRA Q+       +E  +EL
Sbjct: 1579 QSKRAS----FAEKTAQLERSLQE---EHVAVAQLREEAERRAQQQAEAERAREEAEREL 1631

Query: 744  RRLQEEARKEEGQRLARRLQELERDKNLMLATLQQE 779
             R Q +A   E  RL  + +E+ + K+L  A  +++
Sbjct: 1632 ERWQLKA--NEALRLRLQAEEVAQQKSLAQAEAEKQ 1665


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score =  119 bits (297), Expect = 2e-26
 Identities = 173/680 (25%), Positives = 283/680 (41%), Gaps = 92/680 (13%)

Query: 178  QQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRA 237
            +QAE+   + ++L   EE  R   E  +Q+ +  E +A      AR  KA   E E L+A
Sbjct: 1931 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA------ARQRKAALEEVERLKA 1984

Query: 238  ALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLE 297
             +  A  +R+  E+ S R+L+  Q   Q++L +  +AH  A+     + +   +   S+ 
Sbjct: 1985 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2044

Query: 298  TRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWEL 357
             +  GEA+    A  EAE  R Q  +       QV   E L++   EQ  +   +Q    
Sbjct: 2045 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ---- 2100

Query: 358  ERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTR 417
                                A AE L+   +      A  E+   R+ Q +D+ E E  +
Sbjct: 2101 --------------------AAAEKLRKEAEQEAARRAQAEQAALRQKQAADA-EMEKHK 2139

Query: 418  KCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQE--QAILQRS 475
            K      R + +V   +  L+ Q LE +D  K L      L E++     E  +A  QRS
Sbjct: 2140 KFAEQTLRQKAQVEQELTTLRLQ-LEETDHQKNL------LDEELQRLKAEATEAARQRS 2192

Query: 476  LQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETT 535
                  +VE E    +    ELS+          +     E   L++    ++Q +L+  
Sbjct: 2193 ------QVEEELFSVRVQMEELSKL---------KARIEAENRALILRDKDNTQRFLQEE 2237

Query: 536  MAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQ 595
              K++  A +      RLS A ++   +R L    LA  +   E          +  E  
Sbjct: 2238 AEKMKQVAEEAA----RLSVAAQEAARLRQLAEEDLAQQRALAEK---------MLKEKM 2284

Query: 596  QLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLG 655
            Q  +E  RL AE    A L+QQ+   A+EQ    ++   ++AQQL +E Q  Q +     
Sbjct: 2285 QAVQEATRLKAE----AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT----- 2335

Query: 656  LQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEA 715
              LE  RQ Q E + EA  L+  + +      QA  E+ A+   +  E++ +   R   A
Sbjct: 2336 --LEAERQRQLEMSAEAERLKLRVAEMSR--AQARAEEDAQRFRKQAEEIGEKLHRTELA 2391

Query: 716  RREHAKAVVSLRQIQRRAAQEKERSQE-LRRLQEEARKEEGQRLARRLQELERDKNLMLA 774
             +E    V +L   ++++  + ER +E +  L+ E  KE+ Q+ A+ LQ     K+  + 
Sbjct: 2392 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE--KEKLQQEAKLLQL----KSEEMQ 2445

Query: 775  TLQQEGLLSRYK--QQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGS 832
            T+QQE LL   +  QQ  L+   SLL +++ +       E      VA A   RE  +  
Sbjct: 2446 TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ 2505

Query: 833  LSVLLDDLQDLSEAISKEEA 852
               +  + Q L    S EEA
Sbjct: 2506 QQQMEQERQRL--VASMEEA 2523



 Score =  114 bits (284), Expect = 5e-25
 Identities = 166/684 (24%), Positives = 295/684 (43%), Gaps = 88/684 (12%)

Query: 160  EPGRRGRSWGLEGSQALSQQAEVIVRQLQELR------RLEEEVRLL---------RETS 204
            E G + R    E    L ++A    ++ QEL       R E EV L          R TS
Sbjct: 1691 EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1750

Query: 205  LQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLH 264
             + K RLEA+A     LA        EA  LRA    A+  R+  EE + R+  E +R+ 
Sbjct: 1751 EKSKQRLEAEAGRFRELAE-------EAARLRALAEEAKRQRQLAEEDAARQRAEAERVL 1803

Query: 265  QEQLSSL---TQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAE--AQREAELLRK 319
             E+L+++   T+   EA  +L  K E   + L  L    A + + L E  AQ +A++  +
Sbjct: 1804 AEKLAAIGEATRLKTEAEIALKEK-EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1862

Query: 320  --QLSKTQE-DLEAQVTLVENL---RKYVGEQV----PSEVHSQTWELERQKLLETMQHL 369
              QL K  + +LE Q  LVE+    R+ V E++     S   +   + E +  L  ++  
Sbjct: 1863 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1922

Query: 370  QEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREK 429
             ED       AEL   R + L      +  E   +VQ S + E E  R+ ++ L      
Sbjct: 1923 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL 1982

Query: 430  VFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQ--------SQEQAILQRSLQDKAA 481
               +    + +E    +S +QL+    + Q+++ ++         Q++  LQ++LQ + +
Sbjct: 1983 KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2042

Query: 482  EVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEG 541
             ++  R  A+  +     A+EAR + +++ A +  Q+        S++   E   A+ + 
Sbjct: 2043 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE---EQAQARAQA 2099

Query: 542  AAAQLPSLNNRLSYAVRKVHTIRGLIARKLA-----------LAQLRQESCPLPPPVTDV 590
             AA           A R+    +  + +K A             Q  ++   +   +T +
Sbjct: 2100 QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL 2159

Query: 591  SLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAE-------RQQLSKVAQQLEQE 643
             L+L++   ++N LD ELQ   +    E  R R Q E E        ++LSK+  ++E E
Sbjct: 2160 RLQLEETDHQKNLLDEELQ-RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE 2218

Query: 644  -----LQQTQESLASLGLQLEVARQGQQE------STEEAASLRQ----ELTQQQELYGQ 688
                 L+    +   L  + E  +Q  +E      + +EAA LRQ    +L QQ+ L  +
Sbjct: 2219 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEK 2278

Query: 689  ALQEKVAEVE--TRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEK---ERSQEL 743
             L+EK+  V+  TRL+ +    +++   A+ +  +      Q+ ++ A+E    +R+ E 
Sbjct: 2279 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2338

Query: 744  RRLQEEARKEEGQRLARRLQELER 767
             R ++     E +RL  R+ E+ R
Sbjct: 2339 ERQRQLEMSAEAERLKLRVAEMSR 2362



 Score =  112 bits (281), Expect = 1e-24
 Identities = 166/662 (25%), Positives = 275/662 (41%), Gaps = 152/662 (22%)

Query: 188  QELRRLEEEVRLLRETSLQQKMRL-------EAQAMELEALARAEKAGRAEAEGLRAALA 240
            + LRR+EEE RL  +   +++ RL       E Q    EA A+A+     EA+ L+  + 
Sbjct: 1307 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1366

Query: 241  GAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKS-------- 292
              EVVR+   E +  + ++ +R  QE+L  L Q+ E  + +   +AE  E+S        
Sbjct: 1367 -EEVVRR---EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1422

Query: 293  ------LSSLETRRAGEAKELA--------------EAQREAELLRKQLS-KTQEDLEAQ 331
                  L + E +R G   EL               +AQ EAE LR+Q+  ++Q   +A+
Sbjct: 1423 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1482

Query: 332  VTLVENLR--------KYVGEQVPSEVHSQTWELER-------------QKLLETMQH-- 368
            V L   ++        K    Q   E+  Q  E ER             Q  LET Q   
Sbjct: 1483 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSA 1542

Query: 369  ---LQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNR 425
               LQ  R S       L+  +Q     +A   EE  R+ Q     E     + +  L R
Sbjct: 1543 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE-RAREEAERELER 1601

Query: 426  WREKVF-ALMVQLKAQELEHSDSVKQLKGQV----ASLQEKVTSQSQEQAILQRSLQDKA 480
            W+ K   AL ++L+A+E+    S+ Q + +     A  + +   +++EQA+ QR L ++ 
Sbjct: 1602 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ- 1660

Query: 481  AEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVE 540
             E+E +R  A+G   +   A++   R + +T   E+Q +L           LE  +A+++
Sbjct: 1661 -ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL-----------LEEELARLQ 1708

Query: 541  GAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREE 600
              AA        L                +  LA++R E         +V L  +   EE
Sbjct: 1709 REAAAATQKRQEL----------------EAELAKVRAEM--------EVLLASKARAEE 1744

Query: 601  RNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEV 660
             +R  +E   S + ++ E GR RE  E E  +L  +A++ +++ Q  +E  A        
Sbjct: 1745 ESRSTSEK--SKQRLEAEAGRFRELAE-EAARLRALAEEAKRQRQLAEEDAA-------- 1793

Query: 661  ARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHA 720
                      + A   + L ++    G+A + K  E E  L+E+ ++ ER     RR   
Sbjct: 1794 ---------RQRAEAERVLAEKLAAIGEATRLKT-EAEIALKEKEAENER----LRRLAE 1839

Query: 721  KAVVSLRQIQRRAAQEK----ERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATL 776
                  R+++ +AAQ K    ER  +LR+  +               ELER K L+  TL
Sbjct: 1840 DEAFQRRRLEEQAAQHKADIEERLAQLRKASD--------------SELERQKGLVEDTL 1885

Query: 777  QQ 778
            +Q
Sbjct: 1886 RQ 1887



 Score =  102 bits (254), Expect = 2e-21
 Identities = 178/740 (24%), Positives = 321/740 (43%), Gaps = 84/740 (11%)

Query: 131  GHQDVSERRLDTQRPQVTMWERDVSSDRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQEL 190
            G Q+V ER       Q    ERDV  +R    R   +  LE  QA+  Q +V  R+L++L
Sbjct: 1123 GAQEVGERL------QQRHGERDVEVERW---RERVAQLLERWQAVLAQTDVRQRELEQL 1173

Query: 191  RRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAA-LAGAEVVRKNL 249
             R   ++R  RE++              + L    +  R   E ++A  LA ++ VR+ L
Sbjct: 1174 GR---QLRYYRESA--------------DPLGAWLQDARRRQEQIQAMPLADSQAVREQL 1216

Query: 250  EEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAE 309
             +  Q  LEE++R H E++    +  ++ ++++      L    + LE   A  AK+  +
Sbjct: 1217 RQ-EQALLEEIER-HGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV-ASPAKK-PK 1272

Query: 310  AQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQHL 369
             Q  +E + ++    +       TL     K++ E +      +   L  Q+  E  + L
Sbjct: 1273 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE--RLAEQQRAEERERL 1330

Query: 370  QEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREK 429
             E   +L    +L +   Q+       Q E   +++Q    ++ E  R+ ++ ++  ++K
Sbjct: 1331 AEVEAALEKQRQLAEAHAQAKA-----QAEREAKELQ--QRMQEEVVRREEAAVDAQQQK 1383

Query: 430  VFALMVQLKAQELEHSDSVK-QLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERM 488
                 +Q + Q+L  S   + Q K + A   E+   + +E+  + R LQ +A E +  R 
Sbjct: 1384 ---RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR-LQLEATERQ--RG 1437

Query: 489  GAKG-LQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLP 547
            GA+G LQ   +RA+EA  + +Q    AE +LR  V   S  +   E  +A    A A+  
Sbjct: 1438 GAEGELQALRARAEEAEAQKRQAQEEAE-RLRRQVQDESQRKRQAEVELASRVKAEAEAA 1496

Query: 548  SLNNRLSYAVRKVHTIRGLIARKLALAQL---RQESCPLPPPVTDVSLELQQLREERNRL 604
                R   A+ ++        R+L  A++   RQ    L         ELQ  R      
Sbjct: 1497 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1556

Query: 605  DAELQLSARLIQQEVGRAREQGEAERQQ---LSKVAQQLEQELQQTQ-ESLASLGLQLEV 660
             A+L+ S +     V + RE+ E   QQ     +  ++ E+EL++ Q ++  +L L+L+ 
Sbjct: 1557 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1616

Query: 661  ARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHA 720
                QQ+S  +A + +Q+   ++E   +   E+ A  +  L EQ  + +R+L E   +  
Sbjct: 1617 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ-- 1674

Query: 721  KAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEG 780
                     QR AA+     QEL RL+ E  + E QR     Q LE +    LA LQ+E 
Sbjct: 1675 ---------QRLAAE-----QELIRLRAETEQGEQQR-----QLLEEE----LARLQREA 1711

Query: 781  LLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGSLSVLLDD- 839
              +  K+Q L   L  +  + + +++S    E  + +    +    E+  G    L ++ 
Sbjct: 1712 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1771

Query: 840  --LQDLSEAISKEEAVCQGD 857
              L+ L+E   ++  + + D
Sbjct: 1772 ARLRALAEEAKRQRQLAEED 1791



 Score = 94.4 bits (233), Expect = 4e-19
 Identities = 150/642 (23%), Positives = 262/642 (40%), Gaps = 78/642 (12%)

Query: 188  QELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRK 247
            Q  R++EE  RL +    Q + R +AQA        AEK  R EAE   A  A AE    
Sbjct: 2074 QSRRQVEEAERLKQSAEEQAQARAQAQAA-------AEKL-RKEAEQEAARRAQAEQAAL 2125

Query: 248  NLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKEL 307
              ++ +  E+E+ ++  ++ L    Q  +E L++L  + E  +   + L+       +EL
Sbjct: 2126 RQKQAADAEMEKHKKFAEQTLRQKAQVEQE-LTTLRLQLEETDHQKNLLD-------EEL 2177

Query: 308  AEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQ 367
               + EA    +Q S+ +E+L +    +E L K     + + + ++   L  +    T +
Sbjct: 2178 QRLKAEATEAARQRSQVEEELFSVRVQMEELSK-----LKARIEAENRALILRDKDNTQR 2232

Query: 368  HLQEDRDSLHATAE---LLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLN 424
             LQE+ + +   AE    L V  Q    +  L EE+L ++   ++ +  E   K Q++  
Sbjct: 2233 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE---KMQAVQE 2289

Query: 425  RWREKVFA-LMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQ-DKAAE 482
              R K  A L+ Q K    E +  +++ K Q+A    + T   Q     +R  Q + +AE
Sbjct: 2290 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE 2349

Query: 483  VEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLET-------- 534
             E  ++    +    +RA+E  +R+++Q     E+L     A       ++T        
Sbjct: 2350 AERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2409

Query: 535  ---------TMAKVEGAAAQLPSLNNRLSYAVRKVHTIR-------------GLIARKLA 572
                      +A++E    +L      L     ++ T++               ++ K +
Sbjct: 2410 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDS 2469

Query: 573  LAQ----LRQESCPLPPPVTDVSLELQQLREERNRLDAEL-QLSARLIQQEVGRAREQGE 627
            L Q    + QE   L     D   + QQLREE+ R   ++ Q   RL+       R Q E
Sbjct: 2470 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2529

Query: 628  AER---------QQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQE 678
            AE          QQL +  +Q E+ L +  + L      LE   +     +EE  + +  
Sbjct: 2530 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2589

Query: 679  LTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKE 738
             T+       AL    AE E    E   D  RR   A+R     ++S  ++Q R AQ   
Sbjct: 2590 ATKTLPNGRDALDGPAAEAEP---EHSFDGLRRKVSAQRLQEAGILSAEELQ-RLAQGHT 2645

Query: 739  RSQELRRLQEEARKEEGQ-RLARRLQELERDKNLMLATLQQE 779
               EL R ++     +G+  +A  L +   +K  + A LQ++
Sbjct: 2646 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQ 2687



 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 148/636 (23%), Positives = 251/636 (39%), Gaps = 123/636 (19%)

Query: 195  EEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEG-------LRAALAGAEVVRK 247
            EEV    E  L++   + A   ELEA   + K  RA+AE        LR  L GA+ V +
Sbjct: 1070 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1129

Query: 248  NLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSL----------- 296
             L++       EV+R  +E+++ L +  +  L+    +   LE+    L           
Sbjct: 1130 RLQQRHGERDVEVERW-RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG 1188

Query: 297  ----ETRRAGE---AKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPS- 348
                + RR  E   A  LA++Q   E LR++ +  +E +E     VE  +++  + + + 
Sbjct: 1189 AWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE-IERHGEKVEECQRFAKQYINAI 1247

Query: 349  ---EVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVR-------------VQSLTH 392
               E+   T++ + + +    +  +    S     E + +R             ++ ++ 
Sbjct: 1248 KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE 1307

Query: 393  ILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQ-ELEHSDSVKQL 451
             L   EEE  R  +   + E E   + ++ L + R+   A   Q KAQ E E  +  +++
Sbjct: 1308 TLRRMEEE-ERLAEQQRAEERERLAEVEAALEKQRQLAEA-HAQAKAQAEREAKELQQRM 1365

Query: 452  KGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQT 511
            + +V   +E      Q++  +Q  LQ      E E + AK  Q E +     R       
Sbjct: 1366 QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE-IQAKARQAEAAERSRLR------- 1417

Query: 512  ASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKL 571
               EE++R+V       ++ LE T  +  GA  +L +L  R   A               
Sbjct: 1418 --IEEEIRVV-------RLQLEATERQRGGAEGELQALRARAEEA--------------- 1453

Query: 572  ALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAERQ 631
                                 + +Q +EE  RL        R +Q E  R R Q E E  
Sbjct: 1454 -------------------EAQKRQAQEEAERL-------RRQVQDESQRKR-QAEVELA 1486

Query: 632  QLSKVAQQLEQELQQTQESLASLGLQLEVA-RQGQQESTEEAASLRQELTQQQELYGQAL 690
               K   +  +E Q+  ++L  L LQ E A R+ +Q   E A  ++  L   Q      L
Sbjct: 1487 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAEL 1546

Query: 691  QEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQE-------KERSQEL 743
            Q K A       E+ +  ER L E   EH        + +RRA Q+       +E  +EL
Sbjct: 1547 QSKRAS----FAEKTAQLERSLQE---EHVAVAQLREEAERRAQQQAEAERAREEAEREL 1599

Query: 744  RRLQEEARKEEGQRLARRLQELERDKNLMLATLQQE 779
             R Q +A   E  RL  + +E+ + K+L  A  +++
Sbjct: 1600 ERWQLKA--NEALRLRLQAEEVAQQKSLAQAEAEKQ 1633


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score =  119 bits (297), Expect = 2e-26
 Identities = 173/680 (25%), Positives = 283/680 (41%), Gaps = 92/680 (13%)

Query: 178  QQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRA 237
            +QAE+   + ++L   EE  R   E  +Q+ +  E +A      AR  KA   E E L+A
Sbjct: 2100 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA------ARQRKAALEEVERLKA 2153

Query: 238  ALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLE 297
             +  A  +R+  E+ S R+L+  Q   Q++L +  +AH  A+     + +   +   S+ 
Sbjct: 2154 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2213

Query: 298  TRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWEL 357
             +  GEA+    A  EAE  R Q  +       QV   E L++   EQ  +   +Q    
Sbjct: 2214 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ---- 2269

Query: 358  ERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTR 417
                                A AE L+   +      A  E+   R+ Q +D+ E E  +
Sbjct: 2270 --------------------AAAEKLRKEAEQEAARRAQAEQAALRQKQAADA-EMEKHK 2308

Query: 418  KCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQE--QAILQRS 475
            K      R + +V   +  L+ Q LE +D  K L      L E++     E  +A  QRS
Sbjct: 2309 KFAEQTLRQKAQVEQELTTLRLQ-LEETDHQKNL------LDEELQRLKAEATEAARQRS 2361

Query: 476  LQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETT 535
                  +VE E    +    ELS+          +     E   L++    ++Q +L+  
Sbjct: 2362 ------QVEEELFSVRVQMEELSKL---------KARIEAENRALILRDKDNTQRFLQEE 2406

Query: 536  MAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQ 595
              K++  A +      RLS A ++   +R L    LA  +   E          +  E  
Sbjct: 2407 AEKMKQVAEEAA----RLSVAAQEAARLRQLAEEDLAQQRALAEK---------MLKEKM 2453

Query: 596  QLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLG 655
            Q  +E  RL AE    A L+QQ+   A+EQ    ++   ++AQQL +E Q  Q +     
Sbjct: 2454 QAVQEATRLKAE----AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT----- 2504

Query: 656  LQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEA 715
              LE  RQ Q E + EA  L+  + +      QA  E+ A+   +  E++ +   R   A
Sbjct: 2505 --LEAERQRQLEMSAEAERLKLRVAEMSR--AQARAEEDAQRFRKQAEEIGEKLHRTELA 2560

Query: 716  RREHAKAVVSLRQIQRRAAQEKERSQE-LRRLQEEARKEEGQRLARRLQELERDKNLMLA 774
             +E    V +L   ++++  + ER +E +  L+ E  KE+ Q+ A+ LQ     K+  + 
Sbjct: 2561 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE--KEKLQQEAKLLQL----KSEEMQ 2614

Query: 775  TLQQEGLLSRYK--QQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGS 832
            T+QQE LL   +  QQ  L+   SLL +++ +       E      VA A   RE  +  
Sbjct: 2615 TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ 2674

Query: 833  LSVLLDDLQDLSEAISKEEA 852
               +  + Q L    S EEA
Sbjct: 2675 QQQMEQERQRL--VASMEEA 2692



 Score =  114 bits (284), Expect = 5e-25
 Identities = 166/684 (24%), Positives = 295/684 (43%), Gaps = 88/684 (12%)

Query: 160  EPGRRGRSWGLEGSQALSQQAEVIVRQLQELR------RLEEEVRLL---------RETS 204
            E G + R    E    L ++A    ++ QEL       R E EV L          R TS
Sbjct: 1860 EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1919

Query: 205  LQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLH 264
             + K RLEA+A     LA        EA  LRA    A+  R+  EE + R+  E +R+ 
Sbjct: 1920 EKSKQRLEAEAGRFRELAE-------EAARLRALAEEAKRQRQLAEEDAARQRAEAERVL 1972

Query: 265  QEQLSSL---TQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAE--AQREAELLRK 319
             E+L+++   T+   EA  +L  K E   + L  L    A + + L E  AQ +A++  +
Sbjct: 1973 AEKLAAIGEATRLKTEAEIALKEK-EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 2031

Query: 320  --QLSKTQE-DLEAQVTLVENL---RKYVGEQV----PSEVHSQTWELERQKLLETMQHL 369
              QL K  + +LE Q  LVE+    R+ V E++     S   +   + E +  L  ++  
Sbjct: 2032 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 2091

Query: 370  QEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREK 429
             ED       AEL   R + L      +  E   +VQ S + E E  R+ ++ L      
Sbjct: 2092 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL 2151

Query: 430  VFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQ--------SQEQAILQRSLQDKAA 481
               +    + +E    +S +QL+    + Q+++ ++         Q++  LQ++LQ + +
Sbjct: 2152 KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2211

Query: 482  EVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEG 541
             ++  R  A+  +     A+EAR + +++ A +  Q+        S++   E   A+ + 
Sbjct: 2212 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE---EQAQARAQA 2268

Query: 542  AAAQLPSLNNRLSYAVRKVHTIRGLIARKLA-----------LAQLRQESCPLPPPVTDV 590
             AA           A R+    +  + +K A             Q  ++   +   +T +
Sbjct: 2269 QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL 2328

Query: 591  SLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAE-------RQQLSKVAQQLEQE 643
             L+L++   ++N LD ELQ   +    E  R R Q E E        ++LSK+  ++E E
Sbjct: 2329 RLQLEETDHQKNLLDEELQ-RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE 2387

Query: 644  -----LQQTQESLASLGLQLEVARQGQQE------STEEAASLRQ----ELTQQQELYGQ 688
                 L+    +   L  + E  +Q  +E      + +EAA LRQ    +L QQ+ L  +
Sbjct: 2388 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEK 2447

Query: 689  ALQEKVAEVE--TRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEK---ERSQEL 743
             L+EK+  V+  TRL+ +    +++   A+ +  +      Q+ ++ A+E    +R+ E 
Sbjct: 2448 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2507

Query: 744  RRLQEEARKEEGQRLARRLQELER 767
             R ++     E +RL  R+ E+ R
Sbjct: 2508 ERQRQLEMSAEAERLKLRVAEMSR 2531



 Score =  112 bits (281), Expect = 1e-24
 Identities = 166/662 (25%), Positives = 275/662 (41%), Gaps = 152/662 (22%)

Query: 188  QELRRLEEEVRLLRETSLQQKMRL-------EAQAMELEALARAEKAGRAEAEGLRAALA 240
            + LRR+EEE RL  +   +++ RL       E Q    EA A+A+     EA+ L+  + 
Sbjct: 1476 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1535

Query: 241  GAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKS-------- 292
              EVVR+   E +  + ++ +R  QE+L  L Q+ E  + +   +AE  E+S        
Sbjct: 1536 -EEVVRR---EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1591

Query: 293  ------LSSLETRRAGEAKELA--------------EAQREAELLRKQLS-KTQEDLEAQ 331
                  L + E +R G   EL               +AQ EAE LR+Q+  ++Q   +A+
Sbjct: 1592 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1651

Query: 332  VTLVENLR--------KYVGEQVPSEVHSQTWELER-------------QKLLETMQH-- 368
            V L   ++        K    Q   E+  Q  E ER             Q  LET Q   
Sbjct: 1652 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSA 1711

Query: 369  ---LQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNR 425
               LQ  R S       L+  +Q     +A   EE  R+ Q     E     + +  L R
Sbjct: 1712 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE-RAREEAERELER 1770

Query: 426  WREKVF-ALMVQLKAQELEHSDSVKQLKGQV----ASLQEKVTSQSQEQAILQRSLQDKA 480
            W+ K   AL ++L+A+E+    S+ Q + +     A  + +   +++EQA+ QR L ++ 
Sbjct: 1771 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ- 1829

Query: 481  AEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVE 540
             E+E +R  A+G   +   A++   R + +T   E+Q +L           LE  +A+++
Sbjct: 1830 -ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL-----------LEEELARLQ 1877

Query: 541  GAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREE 600
              AA        L                +  LA++R E         +V L  +   EE
Sbjct: 1878 REAAAATQKRQEL----------------EAELAKVRAEM--------EVLLASKARAEE 1913

Query: 601  RNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEV 660
             +R  +E   S + ++ E GR RE  E E  +L  +A++ +++ Q  +E  A        
Sbjct: 1914 ESRSTSEK--SKQRLEAEAGRFRELAE-EAARLRALAEEAKRQRQLAEEDAA-------- 1962

Query: 661  ARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHA 720
                      + A   + L ++    G+A + K  E E  L+E+ ++ ER     RR   
Sbjct: 1963 ---------RQRAEAERVLAEKLAAIGEATRLKT-EAEIALKEKEAENER----LRRLAE 2008

Query: 721  KAVVSLRQIQRRAAQEK----ERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATL 776
                  R+++ +AAQ K    ER  +LR+  +               ELER K L+  TL
Sbjct: 2009 DEAFQRRRLEEQAAQHKADIEERLAQLRKASD--------------SELERQKGLVEDTL 2054

Query: 777  QQ 778
            +Q
Sbjct: 2055 RQ 2056



 Score =  102 bits (254), Expect = 2e-21
 Identities = 178/740 (24%), Positives = 321/740 (43%), Gaps = 84/740 (11%)

Query: 131  GHQDVSERRLDTQRPQVTMWERDVSSDRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQEL 190
            G Q+V ER       Q    ERDV  +R    R   +  LE  QA+  Q +V  R+L++L
Sbjct: 1292 GAQEVGERL------QQRHGERDVEVERW---RERVAQLLERWQAVLAQTDVRQRELEQL 1342

Query: 191  RRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAA-LAGAEVVRKNL 249
             R   ++R  RE++              + L    +  R   E ++A  LA ++ VR+ L
Sbjct: 1343 GR---QLRYYRESA--------------DPLGAWLQDARRRQEQIQAMPLADSQAVREQL 1385

Query: 250  EEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAE 309
             +  Q  LEE++R H E++    +  ++ ++++      L    + LE   A  AK+  +
Sbjct: 1386 RQ-EQALLEEIER-HGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV-ASPAKK-PK 1441

Query: 310  AQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQHL 369
             Q  +E + ++    +       TL     K++ E +      +   L  Q+  E  + L
Sbjct: 1442 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE--RLAEQQRAEERERL 1499

Query: 370  QEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREK 429
             E   +L    +L +   Q+       Q E   +++Q    ++ E  R+ ++ ++  ++K
Sbjct: 1500 AEVEAALEKQRQLAEAHAQAKA-----QAEREAKELQ--QRMQEEVVRREEAAVDAQQQK 1552

Query: 430  VFALMVQLKAQELEHSDSVK-QLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERM 488
                 +Q + Q+L  S   + Q K + A   E+   + +E+  + R LQ +A E +  R 
Sbjct: 1553 ---RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR-LQLEATERQ--RG 1606

Query: 489  GAKG-LQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLP 547
            GA+G LQ   +RA+EA  + +Q    AE +LR  V   S  +   E  +A    A A+  
Sbjct: 1607 GAEGELQALRARAEEAEAQKRQAQEEAE-RLRRQVQDESQRKRQAEVELASRVKAEAEAA 1665

Query: 548  SLNNRLSYAVRKVHTIRGLIARKLALAQL---RQESCPLPPPVTDVSLELQQLREERNRL 604
                R   A+ ++        R+L  A++   RQ    L         ELQ  R      
Sbjct: 1666 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1725

Query: 605  DAELQLSARLIQQEVGRAREQGEAERQQ---LSKVAQQLEQELQQTQ-ESLASLGLQLEV 660
             A+L+ S +     V + RE+ E   QQ     +  ++ E+EL++ Q ++  +L L+L+ 
Sbjct: 1726 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1785

Query: 661  ARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHA 720
                QQ+S  +A + +Q+   ++E   +   E+ A  +  L EQ  + +R+L E   +  
Sbjct: 1786 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ-- 1843

Query: 721  KAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEG 780
                     QR AA+     QEL RL+ E  + E QR     Q LE +    LA LQ+E 
Sbjct: 1844 ---------QRLAAE-----QELIRLRAETEQGEQQR-----QLLEEE----LARLQREA 1880

Query: 781  LLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGSLSVLLDD- 839
              +  K+Q L   L  +  + + +++S    E  + +    +    E+  G    L ++ 
Sbjct: 1881 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1940

Query: 840  --LQDLSEAISKEEAVCQGD 857
              L+ L+E   ++  + + D
Sbjct: 1941 ARLRALAEEAKRQRQLAEED 1960



 Score = 94.4 bits (233), Expect = 4e-19
 Identities = 150/642 (23%), Positives = 262/642 (40%), Gaps = 78/642 (12%)

Query: 188  QELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRK 247
            Q  R++EE  RL +    Q + R +AQA        AEK  R EAE   A  A AE    
Sbjct: 2243 QSRRQVEEAERLKQSAEEQAQARAQAQAA-------AEKL-RKEAEQEAARRAQAEQAAL 2294

Query: 248  NLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKEL 307
              ++ +  E+E+ ++  ++ L    Q  +E L++L  + E  +   + L+       +EL
Sbjct: 2295 RQKQAADAEMEKHKKFAEQTLRQKAQVEQE-LTTLRLQLEETDHQKNLLD-------EEL 2346

Query: 308  AEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQ 367
               + EA    +Q S+ +E+L +    +E L K     + + + ++   L  +    T +
Sbjct: 2347 QRLKAEATEAARQRSQVEEELFSVRVQMEELSK-----LKARIEAENRALILRDKDNTQR 2401

Query: 368  HLQEDRDSLHATAE---LLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLN 424
             LQE+ + +   AE    L V  Q    +  L EE+L ++   ++ +  E   K Q++  
Sbjct: 2402 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE---KMQAVQE 2458

Query: 425  RWREKVFA-LMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQ-DKAAE 482
              R K  A L+ Q K    E +  +++ K Q+A    + T   Q     +R  Q + +AE
Sbjct: 2459 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE 2518

Query: 483  VEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLET-------- 534
             E  ++    +    +RA+E  +R+++Q     E+L     A       ++T        
Sbjct: 2519 AERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2578

Query: 535  ---------TMAKVEGAAAQLPSLNNRLSYAVRKVHTIR-------------GLIARKLA 572
                      +A++E    +L      L     ++ T++               ++ K +
Sbjct: 2579 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDS 2638

Query: 573  LAQ----LRQESCPLPPPVTDVSLELQQLREERNRLDAEL-QLSARLIQQEVGRAREQGE 627
            L Q    + QE   L     D   + QQLREE+ R   ++ Q   RL+       R Q E
Sbjct: 2639 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2698

Query: 628  AER---------QQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQE 678
            AE          QQL +  +Q E+ L +  + L      LE   +     +EE  + +  
Sbjct: 2699 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2758

Query: 679  LTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKE 738
             T+       AL    AE E    E   D  RR   A+R     ++S  ++Q R AQ   
Sbjct: 2759 ATKTLPNGRDALDGPAAEAEP---EHSFDGLRRKVSAQRLQEAGILSAEELQ-RLAQGHT 2814

Query: 739  RSQELRRLQEEARKEEGQ-RLARRLQELERDKNLMLATLQQE 779
               EL R ++     +G+  +A  L +   +K  + A LQ++
Sbjct: 2815 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQ 2856



 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 148/636 (23%), Positives = 251/636 (39%), Gaps = 123/636 (19%)

Query: 195  EEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEG-------LRAALAGAEVVRK 247
            EEV    E  L++   + A   ELEA   + K  RA+AE        LR  L GA+ V +
Sbjct: 1239 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1298

Query: 248  NLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSL----------- 296
             L++       EV+R  +E+++ L +  +  L+    +   LE+    L           
Sbjct: 1299 RLQQRHGERDVEVERW-RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG 1357

Query: 297  ----ETRRAGE---AKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPS- 348
                + RR  E   A  LA++Q   E LR++ +  +E +E     VE  +++  + + + 
Sbjct: 1358 AWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE-IERHGEKVEECQRFAKQYINAI 1416

Query: 349  ---EVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVR-------------VQSLTH 392
               E+   T++ + + +    +  +    S     E + +R             ++ ++ 
Sbjct: 1417 KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE 1476

Query: 393  ILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQ-ELEHSDSVKQL 451
             L   EEE  R  +   + E E   + ++ L + R+   A   Q KAQ E E  +  +++
Sbjct: 1477 TLRRMEEE-ERLAEQQRAEERERLAEVEAALEKQRQLAEA-HAQAKAQAEREAKELQQRM 1534

Query: 452  KGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQT 511
            + +V   +E      Q++  +Q  LQ      E E + AK  Q E +     R       
Sbjct: 1535 QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE-IQAKARQAEAAERSRLR------- 1586

Query: 512  ASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKL 571
               EE++R+V       ++ LE T  +  GA  +L +L  R   A               
Sbjct: 1587 --IEEEIRVV-------RLQLEATERQRGGAEGELQALRARAEEA--------------- 1622

Query: 572  ALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAERQ 631
                                 + +Q +EE  RL        R +Q E  R R Q E E  
Sbjct: 1623 -------------------EAQKRQAQEEAERL-------RRQVQDESQRKR-QAEVELA 1655

Query: 632  QLSKVAQQLEQELQQTQESLASLGLQLEVA-RQGQQESTEEAASLRQELTQQQELYGQAL 690
               K   +  +E Q+  ++L  L LQ E A R+ +Q   E A  ++  L   Q      L
Sbjct: 1656 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAEL 1715

Query: 691  QEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQE-------KERSQEL 743
            Q K A       E+ +  ER L E   EH        + +RRA Q+       +E  +EL
Sbjct: 1716 QSKRAS----FAEKTAQLERSLQE---EHVAVAQLREEAERRAQQQAEAERAREEAEREL 1768

Query: 744  RRLQEEARKEEGQRLARRLQELERDKNLMLATLQQE 779
             R Q +A   E  RL  + +E+ + K+L  A  +++
Sbjct: 1769 ERWQLKA--NEALRLRLQAEEVAQQKSLAQAEAEKQ 1802


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score =  119 bits (297), Expect = 2e-26
 Identities = 173/680 (25%), Positives = 283/680 (41%), Gaps = 92/680 (13%)

Query: 178  QQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRA 237
            +QAE+   + ++L   EE  R   E  +Q+ +  E +A      AR  KA   E E L+A
Sbjct: 1941 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA------ARQRKAALEEVERLKA 1994

Query: 238  ALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLE 297
             +  A  +R+  E+ S R+L+  Q   Q++L +  +AH  A+     + +   +   S+ 
Sbjct: 1995 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2054

Query: 298  TRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWEL 357
             +  GEA+    A  EAE  R Q  +       QV   E L++   EQ  +   +Q    
Sbjct: 2055 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ---- 2110

Query: 358  ERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTR 417
                                A AE L+   +      A  E+   R+ Q +D+ E E  +
Sbjct: 2111 --------------------AAAEKLRKEAEQEAARRAQAEQAALRQKQAADA-EMEKHK 2149

Query: 418  KCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQE--QAILQRS 475
            K      R + +V   +  L+ Q LE +D  K L      L E++     E  +A  QRS
Sbjct: 2150 KFAEQTLRQKAQVEQELTTLRLQ-LEETDHQKNL------LDEELQRLKAEATEAARQRS 2202

Query: 476  LQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETT 535
                  +VE E    +    ELS+          +     E   L++    ++Q +L+  
Sbjct: 2203 ------QVEEELFSVRVQMEELSKL---------KARIEAENRALILRDKDNTQRFLQEE 2247

Query: 536  MAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQ 595
              K++  A +      RLS A ++   +R L    LA  +   E          +  E  
Sbjct: 2248 AEKMKQVAEEAA----RLSVAAQEAARLRQLAEEDLAQQRALAEK---------MLKEKM 2294

Query: 596  QLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLG 655
            Q  +E  RL AE    A L+QQ+   A+EQ    ++   ++AQQL +E Q  Q +     
Sbjct: 2295 QAVQEATRLKAE----AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT----- 2345

Query: 656  LQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEA 715
              LE  RQ Q E + EA  L+  + +      QA  E+ A+   +  E++ +   R   A
Sbjct: 2346 --LEAERQRQLEMSAEAERLKLRVAEMSR--AQARAEEDAQRFRKQAEEIGEKLHRTELA 2401

Query: 716  RREHAKAVVSLRQIQRRAAQEKERSQE-LRRLQEEARKEEGQRLARRLQELERDKNLMLA 774
             +E    V +L   ++++  + ER +E +  L+ E  KE+ Q+ A+ LQ     K+  + 
Sbjct: 2402 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE--KEKLQQEAKLLQL----KSEEMQ 2455

Query: 775  TLQQEGLLSRYK--QQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGS 832
            T+QQE LL   +  QQ  L+   SLL +++ +       E      VA A   RE  +  
Sbjct: 2456 TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ 2515

Query: 833  LSVLLDDLQDLSEAISKEEA 852
               +  + Q L    S EEA
Sbjct: 2516 QQQMEQERQRL--VASMEEA 2533



 Score =  114 bits (284), Expect = 5e-25
 Identities = 166/684 (24%), Positives = 295/684 (43%), Gaps = 88/684 (12%)

Query: 160  EPGRRGRSWGLEGSQALSQQAEVIVRQLQELR------RLEEEVRLL---------RETS 204
            E G + R    E    L ++A    ++ QEL       R E EV L          R TS
Sbjct: 1701 EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1760

Query: 205  LQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLH 264
             + K RLEA+A     LA        EA  LRA    A+  R+  EE + R+  E +R+ 
Sbjct: 1761 EKSKQRLEAEAGRFRELAE-------EAARLRALAEEAKRQRQLAEEDAARQRAEAERVL 1813

Query: 265  QEQLSSL---TQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAE--AQREAELLRK 319
             E+L+++   T+   EA  +L  K E   + L  L    A + + L E  AQ +A++  +
Sbjct: 1814 AEKLAAIGEATRLKTEAEIALKEK-EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1872

Query: 320  --QLSKTQE-DLEAQVTLVENL---RKYVGEQV----PSEVHSQTWELERQKLLETMQHL 369
              QL K  + +LE Q  LVE+    R+ V E++     S   +   + E +  L  ++  
Sbjct: 1873 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1932

Query: 370  QEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREK 429
             ED       AEL   R + L      +  E   +VQ S + E E  R+ ++ L      
Sbjct: 1933 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL 1992

Query: 430  VFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQ--------SQEQAILQRSLQDKAA 481
               +    + +E    +S +QL+    + Q+++ ++         Q++  LQ++LQ + +
Sbjct: 1993 KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2052

Query: 482  EVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEG 541
             ++  R  A+  +     A+EAR + +++ A +  Q+        S++   E   A+ + 
Sbjct: 2053 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE---EQAQARAQA 2109

Query: 542  AAAQLPSLNNRLSYAVRKVHTIRGLIARKLA-----------LAQLRQESCPLPPPVTDV 590
             AA           A R+    +  + +K A             Q  ++   +   +T +
Sbjct: 2110 QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL 2169

Query: 591  SLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAE-------RQQLSKVAQQLEQE 643
             L+L++   ++N LD ELQ   +    E  R R Q E E        ++LSK+  ++E E
Sbjct: 2170 RLQLEETDHQKNLLDEELQ-RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE 2228

Query: 644  -----LQQTQESLASLGLQLEVARQGQQE------STEEAASLRQ----ELTQQQELYGQ 688
                 L+    +   L  + E  +Q  +E      + +EAA LRQ    +L QQ+ L  +
Sbjct: 2229 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEK 2288

Query: 689  ALQEKVAEVE--TRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEK---ERSQEL 743
             L+EK+  V+  TRL+ +    +++   A+ +  +      Q+ ++ A+E    +R+ E 
Sbjct: 2289 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2348

Query: 744  RRLQEEARKEEGQRLARRLQELER 767
             R ++     E +RL  R+ E+ R
Sbjct: 2349 ERQRQLEMSAEAERLKLRVAEMSR 2372



 Score =  112 bits (281), Expect = 1e-24
 Identities = 166/662 (25%), Positives = 275/662 (41%), Gaps = 152/662 (22%)

Query: 188  QELRRLEEEVRLLRETSLQQKMRL-------EAQAMELEALARAEKAGRAEAEGLRAALA 240
            + LRR+EEE RL  +   +++ RL       E Q    EA A+A+     EA+ L+  + 
Sbjct: 1317 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1376

Query: 241  GAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKS-------- 292
              EVVR+   E +  + ++ +R  QE+L  L Q+ E  + +   +AE  E+S        
Sbjct: 1377 -EEVVRR---EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1432

Query: 293  ------LSSLETRRAGEAKELA--------------EAQREAELLRKQLS-KTQEDLEAQ 331
                  L + E +R G   EL               +AQ EAE LR+Q+  ++Q   +A+
Sbjct: 1433 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1492

Query: 332  VTLVENLR--------KYVGEQVPSEVHSQTWELER-------------QKLLETMQH-- 368
            V L   ++        K    Q   E+  Q  E ER             Q  LET Q   
Sbjct: 1493 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSA 1552

Query: 369  ---LQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNR 425
               LQ  R S       L+  +Q     +A   EE  R+ Q     E     + +  L R
Sbjct: 1553 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE-RAREEAERELER 1611

Query: 426  WREKVF-ALMVQLKAQELEHSDSVKQLKGQV----ASLQEKVTSQSQEQAILQRSLQDKA 480
            W+ K   AL ++L+A+E+    S+ Q + +     A  + +   +++EQA+ QR L ++ 
Sbjct: 1612 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ- 1670

Query: 481  AEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVE 540
             E+E +R  A+G   +   A++   R + +T   E+Q +L           LE  +A+++
Sbjct: 1671 -ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL-----------LEEELARLQ 1718

Query: 541  GAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREE 600
              AA        L                +  LA++R E         +V L  +   EE
Sbjct: 1719 REAAAATQKRQEL----------------EAELAKVRAEM--------EVLLASKARAEE 1754

Query: 601  RNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEV 660
             +R  +E   S + ++ E GR RE  E E  +L  +A++ +++ Q  +E  A        
Sbjct: 1755 ESRSTSEK--SKQRLEAEAGRFRELAE-EAARLRALAEEAKRQRQLAEEDAA-------- 1803

Query: 661  ARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHA 720
                      + A   + L ++    G+A + K  E E  L+E+ ++ ER     RR   
Sbjct: 1804 ---------RQRAEAERVLAEKLAAIGEATRLKT-EAEIALKEKEAENER----LRRLAE 1849

Query: 721  KAVVSLRQIQRRAAQEK----ERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATL 776
                  R+++ +AAQ K    ER  +LR+  +               ELER K L+  TL
Sbjct: 1850 DEAFQRRRLEEQAAQHKADIEERLAQLRKASD--------------SELERQKGLVEDTL 1895

Query: 777  QQ 778
            +Q
Sbjct: 1896 RQ 1897



 Score =  102 bits (254), Expect = 2e-21
 Identities = 178/740 (24%), Positives = 321/740 (43%), Gaps = 84/740 (11%)

Query: 131  GHQDVSERRLDTQRPQVTMWERDVSSDRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQEL 190
            G Q+V ER       Q    ERDV  +R    R   +  LE  QA+  Q +V  R+L++L
Sbjct: 1133 GAQEVGERL------QQRHGERDVEVERW---RERVAQLLERWQAVLAQTDVRQRELEQL 1183

Query: 191  RRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAA-LAGAEVVRKNL 249
             R   ++R  RE++              + L    +  R   E ++A  LA ++ VR+ L
Sbjct: 1184 GR---QLRYYRESA--------------DPLGAWLQDARRRQEQIQAMPLADSQAVREQL 1226

Query: 250  EEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAE 309
             +  Q  LEE++R H E++    +  ++ ++++      L    + LE   A  AK+  +
Sbjct: 1227 RQ-EQALLEEIER-HGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV-ASPAKK-PK 1282

Query: 310  AQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQHL 369
             Q  +E + ++    +       TL     K++ E +      +   L  Q+  E  + L
Sbjct: 1283 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE--RLAEQQRAEERERL 1340

Query: 370  QEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREK 429
             E   +L    +L +   Q+       Q E   +++Q    ++ E  R+ ++ ++  ++K
Sbjct: 1341 AEVEAALEKQRQLAEAHAQAKA-----QAEREAKELQ--QRMQEEVVRREEAAVDAQQQK 1393

Query: 430  VFALMVQLKAQELEHSDSVK-QLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERM 488
                 +Q + Q+L  S   + Q K + A   E+   + +E+  + R LQ +A E +  R 
Sbjct: 1394 ---RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR-LQLEATERQ--RG 1447

Query: 489  GAKG-LQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLP 547
            GA+G LQ   +RA+EA  + +Q    AE +LR  V   S  +   E  +A    A A+  
Sbjct: 1448 GAEGELQALRARAEEAEAQKRQAQEEAE-RLRRQVQDESQRKRQAEVELASRVKAEAEAA 1506

Query: 548  SLNNRLSYAVRKVHTIRGLIARKLALAQL---RQESCPLPPPVTDVSLELQQLREERNRL 604
                R   A+ ++        R+L  A++   RQ    L         ELQ  R      
Sbjct: 1507 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1566

Query: 605  DAELQLSARLIQQEVGRAREQGEAERQQ---LSKVAQQLEQELQQTQ-ESLASLGLQLEV 660
             A+L+ S +     V + RE+ E   QQ     +  ++ E+EL++ Q ++  +L L+L+ 
Sbjct: 1567 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1626

Query: 661  ARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHA 720
                QQ+S  +A + +Q+   ++E   +   E+ A  +  L EQ  + +R+L E   +  
Sbjct: 1627 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ-- 1684

Query: 721  KAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEG 780
                     QR AA+     QEL RL+ E  + E QR     Q LE +    LA LQ+E 
Sbjct: 1685 ---------QRLAAE-----QELIRLRAETEQGEQQR-----QLLEEE----LARLQREA 1721

Query: 781  LLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGSLSVLLDD- 839
              +  K+Q L   L  +  + + +++S    E  + +    +    E+  G    L ++ 
Sbjct: 1722 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1781

Query: 840  --LQDLSEAISKEEAVCQGD 857
              L+ L+E   ++  + + D
Sbjct: 1782 ARLRALAEEAKRQRQLAEED 1801



 Score = 94.4 bits (233), Expect = 4e-19
 Identities = 150/642 (23%), Positives = 262/642 (40%), Gaps = 78/642 (12%)

Query: 188  QELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRK 247
            Q  R++EE  RL +    Q + R +AQA        AEK  R EAE   A  A AE    
Sbjct: 2084 QSRRQVEEAERLKQSAEEQAQARAQAQAA-------AEKL-RKEAEQEAARRAQAEQAAL 2135

Query: 248  NLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKEL 307
              ++ +  E+E+ ++  ++ L    Q  +E L++L  + E  +   + L+       +EL
Sbjct: 2136 RQKQAADAEMEKHKKFAEQTLRQKAQVEQE-LTTLRLQLEETDHQKNLLD-------EEL 2187

Query: 308  AEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQ 367
               + EA    +Q S+ +E+L +    +E L K     + + + ++   L  +    T +
Sbjct: 2188 QRLKAEATEAARQRSQVEEELFSVRVQMEELSK-----LKARIEAENRALILRDKDNTQR 2242

Query: 368  HLQEDRDSLHATAE---LLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLN 424
             LQE+ + +   AE    L V  Q    +  L EE+L ++   ++ +  E   K Q++  
Sbjct: 2243 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE---KMQAVQE 2299

Query: 425  RWREKVFA-LMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQ-DKAAE 482
              R K  A L+ Q K    E +  +++ K Q+A    + T   Q     +R  Q + +AE
Sbjct: 2300 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE 2359

Query: 483  VEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLET-------- 534
             E  ++    +    +RA+E  +R+++Q     E+L     A       ++T        
Sbjct: 2360 AERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2419

Query: 535  ---------TMAKVEGAAAQLPSLNNRLSYAVRKVHTIR-------------GLIARKLA 572
                      +A++E    +L      L     ++ T++               ++ K +
Sbjct: 2420 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDS 2479

Query: 573  LAQ----LRQESCPLPPPVTDVSLELQQLREERNRLDAEL-QLSARLIQQEVGRAREQGE 627
            L Q    + QE   L     D   + QQLREE+ R   ++ Q   RL+       R Q E
Sbjct: 2480 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2539

Query: 628  AER---------QQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQE 678
            AE          QQL +  +Q E+ L +  + L      LE   +     +EE  + +  
Sbjct: 2540 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2599

Query: 679  LTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKE 738
             T+       AL    AE E    E   D  RR   A+R     ++S  ++Q R AQ   
Sbjct: 2600 ATKTLPNGRDALDGPAAEAEP---EHSFDGLRRKVSAQRLQEAGILSAEELQ-RLAQGHT 2655

Query: 739  RSQELRRLQEEARKEEGQ-RLARRLQELERDKNLMLATLQQE 779
               EL R ++     +G+  +A  L +   +K  + A LQ++
Sbjct: 2656 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQ 2697



 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 148/636 (23%), Positives = 251/636 (39%), Gaps = 123/636 (19%)

Query: 195  EEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEG-------LRAALAGAEVVRK 247
            EEV    E  L++   + A   ELEA   + K  RA+AE        LR  L GA+ V +
Sbjct: 1080 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1139

Query: 248  NLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSL----------- 296
             L++       EV+R  +E+++ L +  +  L+    +   LE+    L           
Sbjct: 1140 RLQQRHGERDVEVERW-RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG 1198

Query: 297  ----ETRRAGE---AKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPS- 348
                + RR  E   A  LA++Q   E LR++ +  +E +E     VE  +++  + + + 
Sbjct: 1199 AWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE-IERHGEKVEECQRFAKQYINAI 1257

Query: 349  ---EVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVR-------------VQSLTH 392
               E+   T++ + + +    +  +    S     E + +R             ++ ++ 
Sbjct: 1258 KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE 1317

Query: 393  ILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQ-ELEHSDSVKQL 451
             L   EEE  R  +   + E E   + ++ L + R+   A   Q KAQ E E  +  +++
Sbjct: 1318 TLRRMEEE-ERLAEQQRAEERERLAEVEAALEKQRQLAEA-HAQAKAQAEREAKELQQRM 1375

Query: 452  KGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQT 511
            + +V   +E      Q++  +Q  LQ      E E + AK  Q E +     R       
Sbjct: 1376 QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE-IQAKARQAEAAERSRLR------- 1427

Query: 512  ASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKL 571
               EE++R+V       ++ LE T  +  GA  +L +L  R   A               
Sbjct: 1428 --IEEEIRVV-------RLQLEATERQRGGAEGELQALRARAEEA--------------- 1463

Query: 572  ALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAERQ 631
                                 + +Q +EE  RL        R +Q E  R R Q E E  
Sbjct: 1464 -------------------EAQKRQAQEEAERL-------RRQVQDESQRKR-QAEVELA 1496

Query: 632  QLSKVAQQLEQELQQTQESLASLGLQLEVA-RQGQQESTEEAASLRQELTQQQELYGQAL 690
               K   +  +E Q+  ++L  L LQ E A R+ +Q   E A  ++  L   Q      L
Sbjct: 1497 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAEL 1556

Query: 691  QEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQE-------KERSQEL 743
            Q K A       E+ +  ER L E   EH        + +RRA Q+       +E  +EL
Sbjct: 1557 QSKRAS----FAEKTAQLERSLQE---EHVAVAQLREEAERRAQQQAEAERAREEAEREL 1609

Query: 744  RRLQEEARKEEGQRLARRLQELERDKNLMLATLQQE 779
             R Q +A   E  RL  + +E+ + K+L  A  +++
Sbjct: 1610 ERWQLKA--NEALRLRLQAEEVAQQKSLAQAEAEKQ 1643


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score =  119 bits (297), Expect = 2e-26
 Identities = 173/680 (25%), Positives = 283/680 (41%), Gaps = 92/680 (13%)

Query: 178  QQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRA 237
            +QAE+   + ++L   EE  R   E  +Q+ +  E +A      AR  KA   E E L+A
Sbjct: 1949 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA------ARQRKAALEEVERLKA 2002

Query: 238  ALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLE 297
             +  A  +R+  E+ S R+L+  Q   Q++L +  +AH  A+     + +   +   S+ 
Sbjct: 2003 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2062

Query: 298  TRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWEL 357
             +  GEA+    A  EAE  R Q  +       QV   E L++   EQ  +   +Q    
Sbjct: 2063 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ---- 2118

Query: 358  ERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTR 417
                                A AE L+   +      A  E+   R+ Q +D+ E E  +
Sbjct: 2119 --------------------AAAEKLRKEAEQEAARRAQAEQAALRQKQAADA-EMEKHK 2157

Query: 418  KCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQE--QAILQRS 475
            K      R + +V   +  L+ Q LE +D  K L      L E++     E  +A  QRS
Sbjct: 2158 KFAEQTLRQKAQVEQELTTLRLQ-LEETDHQKNL------LDEELQRLKAEATEAARQRS 2210

Query: 476  LQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETT 535
                  +VE E    +    ELS+          +     E   L++    ++Q +L+  
Sbjct: 2211 ------QVEEELFSVRVQMEELSKL---------KARIEAENRALILRDKDNTQRFLQEE 2255

Query: 536  MAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQ 595
              K++  A +      RLS A ++   +R L    LA  +   E          +  E  
Sbjct: 2256 AEKMKQVAEEAA----RLSVAAQEAARLRQLAEEDLAQQRALAEK---------MLKEKM 2302

Query: 596  QLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLG 655
            Q  +E  RL AE    A L+QQ+   A+EQ    ++   ++AQQL +E Q  Q +     
Sbjct: 2303 QAVQEATRLKAE----AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT----- 2353

Query: 656  LQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEA 715
              LE  RQ Q E + EA  L+  + +      QA  E+ A+   +  E++ +   R   A
Sbjct: 2354 --LEAERQRQLEMSAEAERLKLRVAEMSR--AQARAEEDAQRFRKQAEEIGEKLHRTELA 2409

Query: 716  RREHAKAVVSLRQIQRRAAQEKERSQE-LRRLQEEARKEEGQRLARRLQELERDKNLMLA 774
             +E    V +L   ++++  + ER +E +  L+ E  KE+ Q+ A+ LQ     K+  + 
Sbjct: 2410 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE--KEKLQQEAKLLQL----KSEEMQ 2463

Query: 775  TLQQEGLLSRYK--QQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGS 832
            T+QQE LL   +  QQ  L+   SLL +++ +       E      VA A   RE  +  
Sbjct: 2464 TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ 2523

Query: 833  LSVLLDDLQDLSEAISKEEA 852
               +  + Q L    S EEA
Sbjct: 2524 QQQMEQERQRL--VASMEEA 2541



 Score =  114 bits (284), Expect = 5e-25
 Identities = 166/684 (24%), Positives = 295/684 (43%), Gaps = 88/684 (12%)

Query: 160  EPGRRGRSWGLEGSQALSQQAEVIVRQLQELR------RLEEEVRLL---------RETS 204
            E G + R    E    L ++A    ++ QEL       R E EV L          R TS
Sbjct: 1709 EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1768

Query: 205  LQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLH 264
             + K RLEA+A     LA        EA  LRA    A+  R+  EE + R+  E +R+ 
Sbjct: 1769 EKSKQRLEAEAGRFRELAE-------EAARLRALAEEAKRQRQLAEEDAARQRAEAERVL 1821

Query: 265  QEQLSSL---TQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAE--AQREAELLRK 319
             E+L+++   T+   EA  +L  K E   + L  L    A + + L E  AQ +A++  +
Sbjct: 1822 AEKLAAIGEATRLKTEAEIALKEK-EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1880

Query: 320  --QLSKTQE-DLEAQVTLVENL---RKYVGEQV----PSEVHSQTWELERQKLLETMQHL 369
              QL K  + +LE Q  LVE+    R+ V E++     S   +   + E +  L  ++  
Sbjct: 1881 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1940

Query: 370  QEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREK 429
             ED       AEL   R + L      +  E   +VQ S + E E  R+ ++ L      
Sbjct: 1941 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL 2000

Query: 430  VFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQ--------SQEQAILQRSLQDKAA 481
               +    + +E    +S +QL+    + Q+++ ++         Q++  LQ++LQ + +
Sbjct: 2001 KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2060

Query: 482  EVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEG 541
             ++  R  A+  +     A+EAR + +++ A +  Q+        S++   E   A+ + 
Sbjct: 2061 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE---EQAQARAQA 2117

Query: 542  AAAQLPSLNNRLSYAVRKVHTIRGLIARKLA-----------LAQLRQESCPLPPPVTDV 590
             AA           A R+    +  + +K A             Q  ++   +   +T +
Sbjct: 2118 QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL 2177

Query: 591  SLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAE-------RQQLSKVAQQLEQE 643
             L+L++   ++N LD ELQ   +    E  R R Q E E        ++LSK+  ++E E
Sbjct: 2178 RLQLEETDHQKNLLDEELQ-RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE 2236

Query: 644  -----LQQTQESLASLGLQLEVARQGQQE------STEEAASLRQ----ELTQQQELYGQ 688
                 L+    +   L  + E  +Q  +E      + +EAA LRQ    +L QQ+ L  +
Sbjct: 2237 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEK 2296

Query: 689  ALQEKVAEVE--TRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEK---ERSQEL 743
             L+EK+  V+  TRL+ +    +++   A+ +  +      Q+ ++ A+E    +R+ E 
Sbjct: 2297 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2356

Query: 744  RRLQEEARKEEGQRLARRLQELER 767
             R ++     E +RL  R+ E+ R
Sbjct: 2357 ERQRQLEMSAEAERLKLRVAEMSR 2380



 Score =  112 bits (281), Expect = 1e-24
 Identities = 166/662 (25%), Positives = 275/662 (41%), Gaps = 152/662 (22%)

Query: 188  QELRRLEEEVRLLRETSLQQKMRL-------EAQAMELEALARAEKAGRAEAEGLRAALA 240
            + LRR+EEE RL  +   +++ RL       E Q    EA A+A+     EA+ L+  + 
Sbjct: 1325 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1384

Query: 241  GAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKS-------- 292
              EVVR+   E +  + ++ +R  QE+L  L Q+ E  + +   +AE  E+S        
Sbjct: 1385 -EEVVRR---EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1440

Query: 293  ------LSSLETRRAGEAKELA--------------EAQREAELLRKQLS-KTQEDLEAQ 331
                  L + E +R G   EL               +AQ EAE LR+Q+  ++Q   +A+
Sbjct: 1441 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1500

Query: 332  VTLVENLR--------KYVGEQVPSEVHSQTWELER-------------QKLLETMQH-- 368
            V L   ++        K    Q   E+  Q  E ER             Q  LET Q   
Sbjct: 1501 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSA 1560

Query: 369  ---LQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNR 425
               LQ  R S       L+  +Q     +A   EE  R+ Q     E     + +  L R
Sbjct: 1561 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE-RAREEAERELER 1619

Query: 426  WREKVF-ALMVQLKAQELEHSDSVKQLKGQV----ASLQEKVTSQSQEQAILQRSLQDKA 480
            W+ K   AL ++L+A+E+    S+ Q + +     A  + +   +++EQA+ QR L ++ 
Sbjct: 1620 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ- 1678

Query: 481  AEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVE 540
             E+E +R  A+G   +   A++   R + +T   E+Q +L           LE  +A+++
Sbjct: 1679 -ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL-----------LEEELARLQ 1726

Query: 541  GAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREE 600
              AA        L                +  LA++R E         +V L  +   EE
Sbjct: 1727 REAAAATQKRQEL----------------EAELAKVRAEM--------EVLLASKARAEE 1762

Query: 601  RNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEV 660
             +R  +E   S + ++ E GR RE  E E  +L  +A++ +++ Q  +E  A        
Sbjct: 1763 ESRSTSEK--SKQRLEAEAGRFRELAE-EAARLRALAEEAKRQRQLAEEDAA-------- 1811

Query: 661  ARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHA 720
                      + A   + L ++    G+A + K  E E  L+E+ ++ ER     RR   
Sbjct: 1812 ---------RQRAEAERVLAEKLAAIGEATRLKT-EAEIALKEKEAENER----LRRLAE 1857

Query: 721  KAVVSLRQIQRRAAQEK----ERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATL 776
                  R+++ +AAQ K    ER  +LR+  +               ELER K L+  TL
Sbjct: 1858 DEAFQRRRLEEQAAQHKADIEERLAQLRKASD--------------SELERQKGLVEDTL 1903

Query: 777  QQ 778
            +Q
Sbjct: 1904 RQ 1905



 Score =  102 bits (254), Expect = 2e-21
 Identities = 178/740 (24%), Positives = 321/740 (43%), Gaps = 84/740 (11%)

Query: 131  GHQDVSERRLDTQRPQVTMWERDVSSDRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQEL 190
            G Q+V ER       Q    ERDV  +R    R   +  LE  QA+  Q +V  R+L++L
Sbjct: 1141 GAQEVGERL------QQRHGERDVEVERW---RERVAQLLERWQAVLAQTDVRQRELEQL 1191

Query: 191  RRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAA-LAGAEVVRKNL 249
             R   ++R  RE++              + L    +  R   E ++A  LA ++ VR+ L
Sbjct: 1192 GR---QLRYYRESA--------------DPLGAWLQDARRRQEQIQAMPLADSQAVREQL 1234

Query: 250  EEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAE 309
             +  Q  LEE++R H E++    +  ++ ++++      L    + LE   A  AK+  +
Sbjct: 1235 RQ-EQALLEEIER-HGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV-ASPAKK-PK 1290

Query: 310  AQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQHL 369
             Q  +E + ++    +       TL     K++ E +      +   L  Q+  E  + L
Sbjct: 1291 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE--RLAEQQRAEERERL 1348

Query: 370  QEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREK 429
             E   +L    +L +   Q+       Q E   +++Q    ++ E  R+ ++ ++  ++K
Sbjct: 1349 AEVEAALEKQRQLAEAHAQAKA-----QAEREAKELQ--QRMQEEVVRREEAAVDAQQQK 1401

Query: 430  VFALMVQLKAQELEHSDSVK-QLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERM 488
                 +Q + Q+L  S   + Q K + A   E+   + +E+  + R LQ +A E +  R 
Sbjct: 1402 ---RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR-LQLEATERQ--RG 1455

Query: 489  GAKG-LQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLP 547
            GA+G LQ   +RA+EA  + +Q    AE +LR  V   S  +   E  +A    A A+  
Sbjct: 1456 GAEGELQALRARAEEAEAQKRQAQEEAE-RLRRQVQDESQRKRQAEVELASRVKAEAEAA 1514

Query: 548  SLNNRLSYAVRKVHTIRGLIARKLALAQL---RQESCPLPPPVTDVSLELQQLREERNRL 604
                R   A+ ++        R+L  A++   RQ    L         ELQ  R      
Sbjct: 1515 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1574

Query: 605  DAELQLSARLIQQEVGRAREQGEAERQQ---LSKVAQQLEQELQQTQ-ESLASLGLQLEV 660
             A+L+ S +     V + RE+ E   QQ     +  ++ E+EL++ Q ++  +L L+L+ 
Sbjct: 1575 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1634

Query: 661  ARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHA 720
                QQ+S  +A + +Q+   ++E   +   E+ A  +  L EQ  + +R+L E   +  
Sbjct: 1635 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ-- 1692

Query: 721  KAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEG 780
                     QR AA+     QEL RL+ E  + E QR     Q LE +    LA LQ+E 
Sbjct: 1693 ---------QRLAAE-----QELIRLRAETEQGEQQR-----QLLEEE----LARLQREA 1729

Query: 781  LLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGSLSVLLDD- 839
              +  K+Q L   L  +  + + +++S    E  + +    +    E+  G    L ++ 
Sbjct: 1730 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1789

Query: 840  --LQDLSEAISKEEAVCQGD 857
              L+ L+E   ++  + + D
Sbjct: 1790 ARLRALAEEAKRQRQLAEED 1809



 Score = 94.4 bits (233), Expect = 4e-19
 Identities = 150/642 (23%), Positives = 262/642 (40%), Gaps = 78/642 (12%)

Query: 188  QELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRK 247
            Q  R++EE  RL +    Q + R +AQA        AEK  R EAE   A  A AE    
Sbjct: 2092 QSRRQVEEAERLKQSAEEQAQARAQAQAA-------AEKL-RKEAEQEAARRAQAEQAAL 2143

Query: 248  NLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKEL 307
              ++ +  E+E+ ++  ++ L    Q  +E L++L  + E  +   + L+       +EL
Sbjct: 2144 RQKQAADAEMEKHKKFAEQTLRQKAQVEQE-LTTLRLQLEETDHQKNLLD-------EEL 2195

Query: 308  AEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQ 367
               + EA    +Q S+ +E+L +    +E L K     + + + ++   L  +    T +
Sbjct: 2196 QRLKAEATEAARQRSQVEEELFSVRVQMEELSK-----LKARIEAENRALILRDKDNTQR 2250

Query: 368  HLQEDRDSLHATAE---LLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLN 424
             LQE+ + +   AE    L V  Q    +  L EE+L ++   ++ +  E   K Q++  
Sbjct: 2251 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE---KMQAVQE 2307

Query: 425  RWREKVFA-LMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQ-DKAAE 482
              R K  A L+ Q K    E +  +++ K Q+A    + T   Q     +R  Q + +AE
Sbjct: 2308 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE 2367

Query: 483  VEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLET-------- 534
             E  ++    +    +RA+E  +R+++Q     E+L     A       ++T        
Sbjct: 2368 AERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2427

Query: 535  ---------TMAKVEGAAAQLPSLNNRLSYAVRKVHTIR-------------GLIARKLA 572
                      +A++E    +L      L     ++ T++               ++ K +
Sbjct: 2428 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDS 2487

Query: 573  LAQ----LRQESCPLPPPVTDVSLELQQLREERNRLDAEL-QLSARLIQQEVGRAREQGE 627
            L Q    + QE   L     D   + QQLREE+ R   ++ Q   RL+       R Q E
Sbjct: 2488 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2547

Query: 628  AER---------QQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQE 678
            AE          QQL +  +Q E+ L +  + L      LE   +     +EE  + +  
Sbjct: 2548 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2607

Query: 679  LTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKE 738
             T+       AL    AE E    E   D  RR   A+R     ++S  ++Q R AQ   
Sbjct: 2608 ATKTLPNGRDALDGPAAEAEP---EHSFDGLRRKVSAQRLQEAGILSAEELQ-RLAQGHT 2663

Query: 739  RSQELRRLQEEARKEEGQ-RLARRLQELERDKNLMLATLQQE 779
               EL R ++     +G+  +A  L +   +K  + A LQ++
Sbjct: 2664 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQ 2705



 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 148/636 (23%), Positives = 251/636 (39%), Gaps = 123/636 (19%)

Query: 195  EEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEG-------LRAALAGAEVVRK 247
            EEV    E  L++   + A   ELEA   + K  RA+AE        LR  L GA+ V +
Sbjct: 1088 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1147

Query: 248  NLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSL----------- 296
             L++       EV+R  +E+++ L +  +  L+    +   LE+    L           
Sbjct: 1148 RLQQRHGERDVEVERW-RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG 1206

Query: 297  ----ETRRAGE---AKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPS- 348
                + RR  E   A  LA++Q   E LR++ +  +E +E     VE  +++  + + + 
Sbjct: 1207 AWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE-IERHGEKVEECQRFAKQYINAI 1265

Query: 349  ---EVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVR-------------VQSLTH 392
               E+   T++ + + +    +  +    S     E + +R             ++ ++ 
Sbjct: 1266 KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE 1325

Query: 393  ILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQ-ELEHSDSVKQL 451
             L   EEE  R  +   + E E   + ++ L + R+   A   Q KAQ E E  +  +++
Sbjct: 1326 TLRRMEEE-ERLAEQQRAEERERLAEVEAALEKQRQLAEA-HAQAKAQAEREAKELQQRM 1383

Query: 452  KGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQT 511
            + +V   +E      Q++  +Q  LQ      E E + AK  Q E +     R       
Sbjct: 1384 QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE-IQAKARQAEAAERSRLR------- 1435

Query: 512  ASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKL 571
               EE++R+V       ++ LE T  +  GA  +L +L  R   A               
Sbjct: 1436 --IEEEIRVV-------RLQLEATERQRGGAEGELQALRARAEEA--------------- 1471

Query: 572  ALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAERQ 631
                                 + +Q +EE  RL        R +Q E  R R Q E E  
Sbjct: 1472 -------------------EAQKRQAQEEAERL-------RRQVQDESQRKR-QAEVELA 1504

Query: 632  QLSKVAQQLEQELQQTQESLASLGLQLEVA-RQGQQESTEEAASLRQELTQQQELYGQAL 690
               K   +  +E Q+  ++L  L LQ E A R+ +Q   E A  ++  L   Q      L
Sbjct: 1505 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAEL 1564

Query: 691  QEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQE-------KERSQEL 743
            Q K A       E+ +  ER L E   EH        + +RRA Q+       +E  +EL
Sbjct: 1565 QSKRAS----FAEKTAQLERSLQE---EHVAVAQLREEAERRAQQQAEAERAREEAEREL 1617

Query: 744  RRLQEEARKEEGQRLARRLQELERDKNLMLATLQQE 779
             R Q +A   E  RL  + +E+ + K+L  A  +++
Sbjct: 1618 ERWQLKA--NEALRLRLQAEEVAQQKSLAQAEAEKQ 1651


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score =  119 bits (297), Expect = 2e-26
 Identities = 173/680 (25%), Positives = 283/680 (41%), Gaps = 92/680 (13%)

Query: 178  QQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRA 237
            +QAE+   + ++L   EE  R   E  +Q+ +  E +A      AR  KA   E E L+A
Sbjct: 1990 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA------ARQRKAALEEVERLKA 2043

Query: 238  ALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLE 297
             +  A  +R+  E+ S R+L+  Q   Q++L +  +AH  A+     + +   +   S+ 
Sbjct: 2044 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2103

Query: 298  TRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWEL 357
             +  GEA+    A  EAE  R Q  +       QV   E L++   EQ  +   +Q    
Sbjct: 2104 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ---- 2159

Query: 358  ERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTR 417
                                A AE L+   +      A  E+   R+ Q +D+ E E  +
Sbjct: 2160 --------------------AAAEKLRKEAEQEAARRAQAEQAALRQKQAADA-EMEKHK 2198

Query: 418  KCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQE--QAILQRS 475
            K      R + +V   +  L+ Q LE +D  K L      L E++     E  +A  QRS
Sbjct: 2199 KFAEQTLRQKAQVEQELTTLRLQ-LEETDHQKNL------LDEELQRLKAEATEAARQRS 2251

Query: 476  LQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETT 535
                  +VE E    +    ELS+          +     E   L++    ++Q +L+  
Sbjct: 2252 ------QVEEELFSVRVQMEELSKL---------KARIEAENRALILRDKDNTQRFLQEE 2296

Query: 536  MAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQ 595
              K++  A +      RLS A ++   +R L    LA  +   E          +  E  
Sbjct: 2297 AEKMKQVAEEAA----RLSVAAQEAARLRQLAEEDLAQQRALAEK---------MLKEKM 2343

Query: 596  QLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLG 655
            Q  +E  RL AE    A L+QQ+   A+EQ    ++   ++AQQL +E Q  Q +     
Sbjct: 2344 QAVQEATRLKAE----AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT----- 2394

Query: 656  LQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEA 715
              LE  RQ Q E + EA  L+  + +      QA  E+ A+   +  E++ +   R   A
Sbjct: 2395 --LEAERQRQLEMSAEAERLKLRVAEMSR--AQARAEEDAQRFRKQAEEIGEKLHRTELA 2450

Query: 716  RREHAKAVVSLRQIQRRAAQEKERSQE-LRRLQEEARKEEGQRLARRLQELERDKNLMLA 774
             +E    V +L   ++++  + ER +E +  L+ E  KE+ Q+ A+ LQ     K+  + 
Sbjct: 2451 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE--KEKLQQEAKLLQL----KSEEMQ 2504

Query: 775  TLQQEGLLSRYK--QQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGS 832
            T+QQE LL   +  QQ  L+   SLL +++ +       E      VA A   RE  +  
Sbjct: 2505 TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ 2564

Query: 833  LSVLLDDLQDLSEAISKEEA 852
               +  + Q L    S EEA
Sbjct: 2565 QQQMEQERQRL--VASMEEA 2582



 Score =  114 bits (284), Expect = 5e-25
 Identities = 166/684 (24%), Positives = 295/684 (43%), Gaps = 88/684 (12%)

Query: 160  EPGRRGRSWGLEGSQALSQQAEVIVRQLQELR------RLEEEVRLL---------RETS 204
            E G + R    E    L ++A    ++ QEL       R E EV L          R TS
Sbjct: 1750 EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1809

Query: 205  LQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLH 264
             + K RLEA+A     LA        EA  LRA    A+  R+  EE + R+  E +R+ 
Sbjct: 1810 EKSKQRLEAEAGRFRELAE-------EAARLRALAEEAKRQRQLAEEDAARQRAEAERVL 1862

Query: 265  QEQLSSL---TQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAE--AQREAELLRK 319
             E+L+++   T+   EA  +L  K E   + L  L    A + + L E  AQ +A++  +
Sbjct: 1863 AEKLAAIGEATRLKTEAEIALKEK-EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1921

Query: 320  --QLSKTQE-DLEAQVTLVENL---RKYVGEQV----PSEVHSQTWELERQKLLETMQHL 369
              QL K  + +LE Q  LVE+    R+ V E++     S   +   + E +  L  ++  
Sbjct: 1922 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1981

Query: 370  QEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREK 429
             ED       AEL   R + L      +  E   +VQ S + E E  R+ ++ L      
Sbjct: 1982 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL 2041

Query: 430  VFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQ--------SQEQAILQRSLQDKAA 481
               +    + +E    +S +QL+    + Q+++ ++         Q++  LQ++LQ + +
Sbjct: 2042 KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2101

Query: 482  EVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEG 541
             ++  R  A+  +     A+EAR + +++ A +  Q+        S++   E   A+ + 
Sbjct: 2102 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE---EQAQARAQA 2158

Query: 542  AAAQLPSLNNRLSYAVRKVHTIRGLIARKLA-----------LAQLRQESCPLPPPVTDV 590
             AA           A R+    +  + +K A             Q  ++   +   +T +
Sbjct: 2159 QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL 2218

Query: 591  SLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAE-------RQQLSKVAQQLEQE 643
             L+L++   ++N LD ELQ   +    E  R R Q E E        ++LSK+  ++E E
Sbjct: 2219 RLQLEETDHQKNLLDEELQ-RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE 2277

Query: 644  -----LQQTQESLASLGLQLEVARQGQQE------STEEAASLRQ----ELTQQQELYGQ 688
                 L+    +   L  + E  +Q  +E      + +EAA LRQ    +L QQ+ L  +
Sbjct: 2278 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEK 2337

Query: 689  ALQEKVAEVE--TRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEK---ERSQEL 743
             L+EK+  V+  TRL+ +    +++   A+ +  +      Q+ ++ A+E    +R+ E 
Sbjct: 2338 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2397

Query: 744  RRLQEEARKEEGQRLARRLQELER 767
             R ++     E +RL  R+ E+ R
Sbjct: 2398 ERQRQLEMSAEAERLKLRVAEMSR 2421



 Score =  112 bits (281), Expect = 1e-24
 Identities = 166/662 (25%), Positives = 275/662 (41%), Gaps = 152/662 (22%)

Query: 188  QELRRLEEEVRLLRETSLQQKMRL-------EAQAMELEALARAEKAGRAEAEGLRAALA 240
            + LRR+EEE RL  +   +++ RL       E Q    EA A+A+     EA+ L+  + 
Sbjct: 1366 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1425

Query: 241  GAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKS-------- 292
              EVVR+   E +  + ++ +R  QE+L  L Q+ E  + +   +AE  E+S        
Sbjct: 1426 -EEVVRR---EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1481

Query: 293  ------LSSLETRRAGEAKELA--------------EAQREAELLRKQLS-KTQEDLEAQ 331
                  L + E +R G   EL               +AQ EAE LR+Q+  ++Q   +A+
Sbjct: 1482 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1541

Query: 332  VTLVENLR--------KYVGEQVPSEVHSQTWELER-------------QKLLETMQH-- 368
            V L   ++        K    Q   E+  Q  E ER             Q  LET Q   
Sbjct: 1542 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSA 1601

Query: 369  ---LQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNR 425
               LQ  R S       L+  +Q     +A   EE  R+ Q     E     + +  L R
Sbjct: 1602 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE-RAREEAERELER 1660

Query: 426  WREKVF-ALMVQLKAQELEHSDSVKQLKGQV----ASLQEKVTSQSQEQAILQRSLQDKA 480
            W+ K   AL ++L+A+E+    S+ Q + +     A  + +   +++EQA+ QR L ++ 
Sbjct: 1661 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ- 1719

Query: 481  AEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVE 540
             E+E +R  A+G   +   A++   R + +T   E+Q +L           LE  +A+++
Sbjct: 1720 -ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL-----------LEEELARLQ 1767

Query: 541  GAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREE 600
              AA        L                +  LA++R E         +V L  +   EE
Sbjct: 1768 REAAAATQKRQEL----------------EAELAKVRAEM--------EVLLASKARAEE 1803

Query: 601  RNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEV 660
             +R  +E   S + ++ E GR RE  E E  +L  +A++ +++ Q  +E  A        
Sbjct: 1804 ESRSTSEK--SKQRLEAEAGRFRELAE-EAARLRALAEEAKRQRQLAEEDAA-------- 1852

Query: 661  ARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHA 720
                      + A   + L ++    G+A + K  E E  L+E+ ++ ER     RR   
Sbjct: 1853 ---------RQRAEAERVLAEKLAAIGEATRLKT-EAEIALKEKEAENER----LRRLAE 1898

Query: 721  KAVVSLRQIQRRAAQEK----ERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATL 776
                  R+++ +AAQ K    ER  +LR+  +               ELER K L+  TL
Sbjct: 1899 DEAFQRRRLEEQAAQHKADIEERLAQLRKASD--------------SELERQKGLVEDTL 1944

Query: 777  QQ 778
            +Q
Sbjct: 1945 RQ 1946



 Score =  102 bits (254), Expect = 2e-21
 Identities = 178/740 (24%), Positives = 321/740 (43%), Gaps = 84/740 (11%)

Query: 131  GHQDVSERRLDTQRPQVTMWERDVSSDRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQEL 190
            G Q+V ER       Q    ERDV  +R    R   +  LE  QA+  Q +V  R+L++L
Sbjct: 1182 GAQEVGERL------QQRHGERDVEVERW---RERVAQLLERWQAVLAQTDVRQRELEQL 1232

Query: 191  RRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAA-LAGAEVVRKNL 249
             R   ++R  RE++              + L    +  R   E ++A  LA ++ VR+ L
Sbjct: 1233 GR---QLRYYRESA--------------DPLGAWLQDARRRQEQIQAMPLADSQAVREQL 1275

Query: 250  EEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAE 309
             +  Q  LEE++R H E++    +  ++ ++++      L    + LE   A  AK+  +
Sbjct: 1276 RQ-EQALLEEIER-HGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV-ASPAKK-PK 1331

Query: 310  AQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQHL 369
             Q  +E + ++    +       TL     K++ E +      +   L  Q+  E  + L
Sbjct: 1332 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE--RLAEQQRAEERERL 1389

Query: 370  QEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREK 429
             E   +L    +L +   Q+       Q E   +++Q    ++ E  R+ ++ ++  ++K
Sbjct: 1390 AEVEAALEKQRQLAEAHAQAKA-----QAEREAKELQ--QRMQEEVVRREEAAVDAQQQK 1442

Query: 430  VFALMVQLKAQELEHSDSVK-QLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERM 488
                 +Q + Q+L  S   + Q K + A   E+   + +E+  + R LQ +A E +  R 
Sbjct: 1443 ---RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR-LQLEATERQ--RG 1496

Query: 489  GAKG-LQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLP 547
            GA+G LQ   +RA+EA  + +Q    AE +LR  V   S  +   E  +A    A A+  
Sbjct: 1497 GAEGELQALRARAEEAEAQKRQAQEEAE-RLRRQVQDESQRKRQAEVELASRVKAEAEAA 1555

Query: 548  SLNNRLSYAVRKVHTIRGLIARKLALAQL---RQESCPLPPPVTDVSLELQQLREERNRL 604
                R   A+ ++        R+L  A++   RQ    L         ELQ  R      
Sbjct: 1556 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1615

Query: 605  DAELQLSARLIQQEVGRAREQGEAERQQ---LSKVAQQLEQELQQTQ-ESLASLGLQLEV 660
             A+L+ S +     V + RE+ E   QQ     +  ++ E+EL++ Q ++  +L L+L+ 
Sbjct: 1616 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1675

Query: 661  ARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHA 720
                QQ+S  +A + +Q+   ++E   +   E+ A  +  L EQ  + +R+L E   +  
Sbjct: 1676 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ-- 1733

Query: 721  KAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEG 780
                     QR AA+     QEL RL+ E  + E QR     Q LE +    LA LQ+E 
Sbjct: 1734 ---------QRLAAE-----QELIRLRAETEQGEQQR-----QLLEEE----LARLQREA 1770

Query: 781  LLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGSLSVLLDD- 839
              +  K+Q L   L  +  + + +++S    E  + +    +    E+  G    L ++ 
Sbjct: 1771 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1830

Query: 840  --LQDLSEAISKEEAVCQGD 857
              L+ L+E   ++  + + D
Sbjct: 1831 ARLRALAEEAKRQRQLAEED 1850



 Score = 94.4 bits (233), Expect = 4e-19
 Identities = 150/642 (23%), Positives = 262/642 (40%), Gaps = 78/642 (12%)

Query: 188  QELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRK 247
            Q  R++EE  RL +    Q + R +AQA        AEK  R EAE   A  A AE    
Sbjct: 2133 QSRRQVEEAERLKQSAEEQAQARAQAQAA-------AEKL-RKEAEQEAARRAQAEQAAL 2184

Query: 248  NLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKEL 307
              ++ +  E+E+ ++  ++ L    Q  +E L++L  + E  +   + L+       +EL
Sbjct: 2185 RQKQAADAEMEKHKKFAEQTLRQKAQVEQE-LTTLRLQLEETDHQKNLLD-------EEL 2236

Query: 308  AEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQ 367
               + EA    +Q S+ +E+L +    +E L K     + + + ++   L  +    T +
Sbjct: 2237 QRLKAEATEAARQRSQVEEELFSVRVQMEELSK-----LKARIEAENRALILRDKDNTQR 2291

Query: 368  HLQEDRDSLHATAE---LLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLN 424
             LQE+ + +   AE    L V  Q    +  L EE+L ++   ++ +  E   K Q++  
Sbjct: 2292 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE---KMQAVQE 2348

Query: 425  RWREKVFA-LMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQ-DKAAE 482
              R K  A L+ Q K    E +  +++ K Q+A    + T   Q     +R  Q + +AE
Sbjct: 2349 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE 2408

Query: 483  VEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLET-------- 534
             E  ++    +    +RA+E  +R+++Q     E+L     A       ++T        
Sbjct: 2409 AERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2468

Query: 535  ---------TMAKVEGAAAQLPSLNNRLSYAVRKVHTIR-------------GLIARKLA 572
                      +A++E    +L      L     ++ T++               ++ K +
Sbjct: 2469 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDS 2528

Query: 573  LAQ----LRQESCPLPPPVTDVSLELQQLREERNRLDAEL-QLSARLIQQEVGRAREQGE 627
            L Q    + QE   L     D   + QQLREE+ R   ++ Q   RL+       R Q E
Sbjct: 2529 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2588

Query: 628  AER---------QQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQE 678
            AE          QQL +  +Q E+ L +  + L      LE   +     +EE  + +  
Sbjct: 2589 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2648

Query: 679  LTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKE 738
             T+       AL    AE E    E   D  RR   A+R     ++S  ++Q R AQ   
Sbjct: 2649 ATKTLPNGRDALDGPAAEAEP---EHSFDGLRRKVSAQRLQEAGILSAEELQ-RLAQGHT 2704

Query: 739  RSQELRRLQEEARKEEGQ-RLARRLQELERDKNLMLATLQQE 779
               EL R ++     +G+  +A  L +   +K  + A LQ++
Sbjct: 2705 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQ 2746



 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 148/636 (23%), Positives = 251/636 (39%), Gaps = 123/636 (19%)

Query: 195  EEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEG-------LRAALAGAEVVRK 247
            EEV    E  L++   + A   ELEA   + K  RA+AE        LR  L GA+ V +
Sbjct: 1129 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1188

Query: 248  NLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSL----------- 296
             L++       EV+R  +E+++ L +  +  L+    +   LE+    L           
Sbjct: 1189 RLQQRHGERDVEVERW-RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG 1247

Query: 297  ----ETRRAGE---AKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPS- 348
                + RR  E   A  LA++Q   E LR++ +  +E +E     VE  +++  + + + 
Sbjct: 1248 AWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE-IERHGEKVEECQRFAKQYINAI 1306

Query: 349  ---EVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVR-------------VQSLTH 392
               E+   T++ + + +    +  +    S     E + +R             ++ ++ 
Sbjct: 1307 KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE 1366

Query: 393  ILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQ-ELEHSDSVKQL 451
             L   EEE  R  +   + E E   + ++ L + R+   A   Q KAQ E E  +  +++
Sbjct: 1367 TLRRMEEE-ERLAEQQRAEERERLAEVEAALEKQRQLAEA-HAQAKAQAEREAKELQQRM 1424

Query: 452  KGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQT 511
            + +V   +E      Q++  +Q  LQ      E E + AK  Q E +     R       
Sbjct: 1425 QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE-IQAKARQAEAAERSRLR------- 1476

Query: 512  ASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKL 571
               EE++R+V       ++ LE T  +  GA  +L +L  R   A               
Sbjct: 1477 --IEEEIRVV-------RLQLEATERQRGGAEGELQALRARAEEA--------------- 1512

Query: 572  ALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAERQ 631
                                 + +Q +EE  RL        R +Q E  R R Q E E  
Sbjct: 1513 -------------------EAQKRQAQEEAERL-------RRQVQDESQRKR-QAEVELA 1545

Query: 632  QLSKVAQQLEQELQQTQESLASLGLQLEVA-RQGQQESTEEAASLRQELTQQQELYGQAL 690
               K   +  +E Q+  ++L  L LQ E A R+ +Q   E A  ++  L   Q      L
Sbjct: 1546 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAEL 1605

Query: 691  QEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQE-------KERSQEL 743
            Q K A       E+ +  ER L E   EH        + +RRA Q+       +E  +EL
Sbjct: 1606 QSKRAS----FAEKTAQLERSLQE---EHVAVAQLREEAERRAQQQAEAERAREEAEREL 1658

Query: 744  RRLQEEARKEEGQRLARRLQELERDKNLMLATLQQE 779
             R Q +A   E  RL  + +E+ + K+L  A  +++
Sbjct: 1659 ERWQLKA--NEALRLRLQAEEVAQQKSLAQAEAEKQ 1692


>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
          Length = 2017

 Score =  118 bits (296), Expect = 2e-26
 Identities = 201/776 (25%), Positives = 322/776 (41%), Gaps = 124/776 (15%)

Query: 169  GLEGSQALSQQA-EVIVRQLQELR----RLEEEVRLL------RETSLQQKMR-LEAQAM 216
            GLEGS  +++QA E + +QL  LR    +L+E++  L      RE  L+Q  R  + Q  
Sbjct: 803  GLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVE 862

Query: 217  ELEALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQR----------ELEEVQR---- 262
             LE  AR ++A   E  GL   L  AE   + L E + R           L EVQR    
Sbjct: 863  ALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQ 922

Query: 263  --LHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGE----AKELAEAQREAEL 316
                +EQL +  QA   A  +LT +  GL + + + + + + +    A++L +A+REA+ 
Sbjct: 923  LEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQA 982

Query: 317  -LRKQLSKTQEDL-------EAQVTLVENLRKYVGEQVPSEVHS--QTWELERQKLLETM 366
             LR+Q +  +EDL       EA    +E  R  +  Q+  E        E E+++L E +
Sbjct: 983  SLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEI 1042

Query: 367  QHLQEDRDS--LHATAELLQVRVQSLTHILALQEEEL-TRKVQPSDSLEPEFTRK-CQSL 422
              LQ++RD   L A +E  Q      +   AL E+ + TR    + SLE E  ++  QS 
Sbjct: 1043 AALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSR 1102

Query: 423  LNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDKAAE 482
              + R  V AL  +L+    +  ++      +V  LQE+     +++    R  ++   +
Sbjct: 1103 QEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQ 1162

Query: 483  VEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGA 542
            + +      GL+ EL  AQ   R  Q+      ++               E   +  EGA
Sbjct: 1163 LRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAG-------------ELRRSLGEGA 1209

Query: 543  AAQ--LPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREE 600
              +  L   N  L  AV+K  + R  I+ KLA     Q+   L    T V  E  +LR  
Sbjct: 1210 KEREALRRSNEELRSAVKKAESER--ISLKLANEDKEQKLALLEEARTAVGKEAGELRTG 1267

Query: 601  RNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEV 660
                            QEV R+R +   E Q+L +  + L+ E  +    LA L  +L +
Sbjct: 1268 L---------------QEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLAL 1312

Query: 661  ARQGQQESTEEAASLRQEL----------TQQQELYGQALQEKVAEVETRLREQLSDTE- 709
              + ++ES  E   LRQ L           Q+ ++  + LQE+  E  TR R  L   E 
Sbjct: 1313 GERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEE 1372

Query: 710  -RRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERD 768
             R   + + +HA+ +    +++  AA+ +     LR    E R    Q L   L  +E  
Sbjct: 1373 ARGTEKQQLDHARGL----ELKLEAARAEAAELGLRLSAAEGR---AQGLEAELARVEVQ 1425

Query: 769  KNLMLATLQQEGLLSRYKQQRLLTVLPSLLDK--------------KKSVVSSPRPPECS 814
            +    A  Q  GL S  ++   L   PS   +                  ++SP   ECS
Sbjct: 1426 RR--AAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECS 1483

Query: 815  AS----APVAAAVPTR-----ESIKGSLSVLLDDLQDLSEAISKEEAVCQGDNLDR 861
                  +P  A  P       E+++G+L   L +L+  S    ++E   Q   L+R
Sbjct: 1484 PGSQPPSPGPATSPASPDLDPEAVRGALREFLQELR--SAQRERDELRTQTSALNR 1537



 Score =  113 bits (283), Expect = 7e-25
 Identities = 171/661 (25%), Positives = 291/661 (44%), Gaps = 83/661 (12%)

Query: 215  AMELEALARAEKAGRAEAEG-----LRAALAGAEVVRKNLEEGSQRELEEVQRLHQEQLS 269
            A+    L   +  GR EA       LR  L+ +E  R+ LEE       ++QRL +++  
Sbjct: 527  ALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEE-------QLQRL-RDKTD 578

Query: 270  SLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQREAELLRKQLSKTQEDLE 329
               QAHE+A      + + L  +   L   ++  A  L  AQ++AE LR++  K Q    
Sbjct: 579  GAMQAHEDA----QREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQA--- 631

Query: 330  AQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQS 389
            AQ    E LR+               E E++  ++    ++ + +  H   E L+ +   
Sbjct: 632  AQ----EELRR----------QRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSV 677

Query: 390  LTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVK 449
            L   L    E L+R     D L+ E            + +V   + + +A  +E   S+ 
Sbjct: 678  LAKELVEVREALSRATLQRDMLQAE------------KAEVAEALTKAEAGRVELELSMT 725

Query: 450  QLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQ 509
            +L+ + ASLQ+ ++  S   A+ +   QDK   +++ R+ A+ L+ E S  Q  +R+ +Q
Sbjct: 726  KLRAEEASLQDSLSKLS---ALNESLAQDK---LDLNRLVAQ-LEEEKSALQGRQRQAEQ 778

Query: 510  Q-TASAEEQLRLVVNAVSS--SQIWLETTMAKVEGAAA----QLPSLNNRLSYAVRKVHT 562
            + T + EEQ RL    +    ++  LE ++   E A      QLP+L +  S    ++  
Sbjct: 779  EATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQ 838

Query: 563  I-RGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAEL---QLSARLIQQE 618
            + R L  R+  L Q R+E+      +   + E + L +E   L  +L   +   R + +E
Sbjct: 839  LSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEE 898

Query: 619  VGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQE 678
              R R + EA    L +V +QL Q L+  +E L + G  L +A++     T E A LRQ+
Sbjct: 899  ATRLRLEKEALEGSLFEVQRQLAQ-LEARREQLEAEGQALLLAKE---TLTGELAGLRQQ 954

Query: 679  LTQQQE-------LYGQALQEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQR 731
            +   QE       L  Q L +   E +  LREQ +  E  L   +RE   A   L   + 
Sbjct: 955  IIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERA 1014

Query: 732  RAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEGLLSRYKQQRLL 791
            +   + +R QE    + EA KEE       LQ+ ERD+ L+LA  +++  LS  K+    
Sbjct: 1015 QLQSQLQREQEELLARLEAEKEELSEEIAALQQ-ERDEGLLLAESEKQQALS-LKESEKT 1072

Query: 792  TVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGSLSVLLDDLQDLSEAISKEE 851
             +   L+  + S+ +     E         A   +E  + +++ L  +L+DL     +EE
Sbjct: 1073 ALSEKLMGTRHSLATISLEME----RQKRDAQSRQEQDRSTVNALTSELRDL--RAQREE 1126

Query: 852  A 852
            A
Sbjct: 1127 A 1127



 Score =  102 bits (254), Expect = 2e-21
 Identities = 172/625 (27%), Positives = 264/625 (42%), Gaps = 87/625 (13%)

Query: 189  ELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRKN 248
            E R LEE+++ LR+ +       E    E++ L  A +    E   L  +L  A+   + 
Sbjct: 562  ERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEE 621

Query: 249  LEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKS---LSSLETRRAGEAK 305
            L +  + +L+  Q   + Q   L +  E+A+         LE+S   L  LE +R+  AK
Sbjct: 622  LRQ-EREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAK 680

Query: 306  ELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLET 365
            EL E  REA L R  L +     E +  + E L K       +E      EL   KL   
Sbjct: 681  ELVEV-REA-LSRATLQRDMLQAE-KAEVAEALTK-------AEAGRVELELSMTKLRAE 730

Query: 366  MQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFT--RKCQSLL 423
               LQ+    L A  E L      L  ++A  EEE +         E E T  R+ Q  L
Sbjct: 731  EASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERL 790

Query: 424  NRWR-EKVFA-------LMVQLKAQE--------LEHSDSVKQLKGQVASLQEKVTSQSQ 467
               R E+  A       L V  +AQE        L H  S  QL+ Q+A L  +++ + Q
Sbjct: 791  EELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERS--QLQEQLAQLSRQLSGREQ 848

Query: 468  EQAILQR-------SLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRL 520
            E    +R       +L+  A E E       GL ++L  A+   R   ++      +LRL
Sbjct: 849  ELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEAT----RLRL 904

Query: 521  VVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQES 580
               A+  S   ++  +A++E    QL +    L  A     T+ G +A         QE 
Sbjct: 905  EKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLA---KETLTGELAGLRQQIIATQEK 961

Query: 581  CPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQL 640
              L     D  L  Q+L +      A L+      ++++ R + + EA  ++L     QL
Sbjct: 962  ASL-----DKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQL 1016

Query: 641  EQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQE----LTQQQELYGQALQEKVAE 696
            + +LQ+ QE L +   +LE  +   +E +EE A+L+QE    L   +    QAL  K +E
Sbjct: 1017 QSQLQREQEELLA---RLEAEK---EELSEEIAALQQERDEGLLLAESEKQQALSLKESE 1070

Query: 697  VETRLREQLSDTERRLNEARREHAKAVVSLR-QIQRRAA---QEKERS---------QEL 743
             +T L E+L  T          H+ A +SL  + Q+R A   QE++RS         ++L
Sbjct: 1071 -KTALSEKLMGT---------RHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDL 1120

Query: 744  RRLQEEARKEEGQRLARRLQELERD 768
            R  +EEA     Q + RRLQE  RD
Sbjct: 1121 RAQREEAAAAHAQEV-RRLQEQARD 1144



 Score = 88.2 bits (217), Expect = 3e-17
 Identities = 144/577 (24%), Positives = 233/577 (40%), Gaps = 106/577 (18%)

Query: 187  LQELRRLEEEVRLLR-ETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAA------L 239
            LQELR  + E   LR +TS   +   E +A    A +RA +  +A AE   A       L
Sbjct: 1515 LQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRL 1574

Query: 240  AGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETR 299
            +G +     L+E S R  E  +R   +Q+++L ++ +   S L +  E + K + + ET+
Sbjct: 1575 SGVQA-ELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISK-MKANETK 1632

Query: 300  RAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELER 359
              G+ + L E    +E    +L   +  LE             GE   S +     E + 
Sbjct: 1633 LEGDKRRLKEVLDASESRTVKLELQRRSLE-------------GELQRSRLGLSDREAQA 1679

Query: 360  QKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEE---LTRKVQPSDSLEPEFT 416
            Q L + +  LQ         A  LQ+ V+ L   LA  EE    L  KV+       E  
Sbjct: 1680 QALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLT----EAL 1735

Query: 417  RKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSL 476
             +  + LN  R+K   L   L A E +     ++L     +L E    QS       ++L
Sbjct: 1736 AQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSE-ARKQSSSLGEQVQTL 1794

Query: 477  QDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTM 536
            + + A++E++R+ A+G   +L + +E  R+ Q                            
Sbjct: 1795 RGEVADLELQRVEAEG---QLQQLREVLRQRQ---------------------------- 1823

Query: 537  AKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKL-----ALAQLRQESCPLPPPVTDVS 591
               EG AA L +        V+K+   R L+  +L     ALAQL  E            
Sbjct: 1824 ---EGEAAALNT--------VQKLQDERRLLQERLGSLQRALAQLEAEKR---------E 1863

Query: 592  LELQQLREERNRLDAELQLSARLIQQEVGRAREQG---EAERQQLSKVAQQLEQELQQTQ 648
            +E   LR E++R+   L+ +   +++E  R+ E      AE+ +L +     E EL + Q
Sbjct: 1864 VERSALRLEKDRV--ALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQ 1921

Query: 649  ESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDT 708
              +  L  Q+ V  Q    +  E  + +Q+L  QQE+              RLR   + T
Sbjct: 1922 RQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEV-------------ERLRSAQAQT 1968

Query: 709  ERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRR 745
            ER L    R H + V  L   ++ +  + +  QELRR
Sbjct: 1969 ERTLEARERAHRQRVRGLE--EQVSTLKGQLQQELRR 2003



 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 163/687 (23%), Positives = 263/687 (38%), Gaps = 104/687 (15%)

Query: 144  RPQVTMWERDVSSDRQEPGRRGRSWGLEGSQALSQ----QAEVIVRQLQELRRLEEEVRL 199
            R Q    E D+   ++E     R    E +Q  SQ    Q E++ R   E   L EE+  
Sbjct: 985  REQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAA 1044

Query: 200  LRETSLQQKMRLEAQAMELEALARAEKAGRAEA-EGLRAALAGAEV-------------- 244
            L++   +  +  E++  +  +L  +EK   +E   G R +LA   +              
Sbjct: 1045 LQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQE 1104

Query: 245  ---------------VRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGL 289
                           +R   EE +    +EV+RL QEQ   L +  +  L     +AE L
Sbjct: 1105 QDRSTVNALTSELRDLRAQREEAAAAHAQEVRRL-QEQARDLGKQRDSCLR----EAEEL 1159

Query: 290  EKSLSSLETRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSE 349
               L  LE  R G  +EL EAQR+       L ++QE  E Q      LR+ +GE     
Sbjct: 1160 RTQLRLLEDARDGLRRELLEAQRK-------LRESQEGREVQRQEAGELRRSLGEGAK-- 1210

Query: 350  VHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSD 409
                    ER+ L  + + L+       +    L++  +     LAL EE  T   + + 
Sbjct: 1211 --------EREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAG 1262

Query: 410  SLEPEFTRKCQSLLNRWRE--KVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQ 467
             L        +S L   RE  ++   M  L ++       + +L+G++A L E+   +S+
Sbjct: 1263 ELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLA-LGERAEKESR 1321

Query: 468  EQAI-LQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVS 526
             + + L++ L    A +EV R   +  Q +L   +   R  +++   + E+ R       
Sbjct: 1322 RETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQL 1381

Query: 527  SSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPP 586
                 LE    K+E A A+   L  RLS A  +    +GL A                  
Sbjct: 1382 DHARGLEL---KLEAARAEAAELGLRLSAAEGRA---QGLEA------------------ 1417

Query: 587  VTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQ 646
                  EL ++  +R   +A+L      +++ +G  R    A R      A+    E   
Sbjct: 1418 ------ELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAE--G 1469

Query: 647  TQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVET------R 700
            + E L S    LE +   Q  S   A S        + + G AL+E + E+ +       
Sbjct: 1470 SGEGLNSPST-LECSPGSQPPSPGPATSPASPDLDPEAVRG-ALREFLQELRSAQRERDE 1527

Query: 701  LREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLAR 760
            LR Q S   R+L E   E   A    RQ+Q+  A+    S+E RR  +         LA 
Sbjct: 1528 LRTQTSALNRQLAEMEAERDSATSRARQLQKAVAE----SEEARRSVDGRLSGVQAELAL 1583

Query: 761  RLQELERDKNLMLATLQQEGLLSRYKQ 787
            + + + R +    ATL Q   L R  Q
Sbjct: 1584 QEESVRRSERERRATLDQVATLERSLQ 1610



 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 153/676 (22%), Positives = 273/676 (40%), Gaps = 111/676 (16%)

Query: 171  EGSQALSQQAEVIVRQLQELRRLEEEVRL-LRETSLQQKM------RLEAQAMELEALA- 222
            E   A+ ++A  +   LQE+ R   E R  L+E   Q KM      RL  +  EL+    
Sbjct: 1252 EARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLA 1311

Query: 223  ---RAEKAGRAEAEGLRAAL----AGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAH 275
               RAEK  R E  GLR  L    A  EV+R+ L+  +QR+L+E +   + +   L  + 
Sbjct: 1312 LGERAEKESRRETLGLRQRLLKGEASLEVMRQELQV-AQRKLQEQEGEFRTRERRLLGSL 1370

Query: 276  EEALSSLTSK---AEGLEKSLSSLETRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQV 332
            EEA  +   +   A GLE  L +     A     L+ A+  A+ L  +L++ +    A  
Sbjct: 1371 EEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAE 1430

Query: 333  TLVENLRKYV---------------------GEQVPSEVHSQTWELERQKLLETMQHLQE 371
              +  LR  +                         P+E   +   L     LE     Q 
Sbjct: 1431 AQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEG--LNSPSTLECSPGSQP 1488

Query: 372  DRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSL--LNRWREK 429
                   +     +  +++   L    +EL    +  D L  + +   + L  +   R+ 
Sbjct: 1489 PSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDS 1548

Query: 430  VFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQ--------------EQAILQRS 475
              +   QL+    E  ++ + + G+++ +Q ++  Q +              + A L+RS
Sbjct: 1549 ATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERS 1608

Query: 476  LQD-----KAAEVEVERMGAKGLQLE--LSRAQEARRRWQQQTASAEEQLRLVVNAVSSS 528
            LQ      +A++ ++ +M A   +LE    R +E     + +T   E Q R +   +  S
Sbjct: 1609 LQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRS 1668

Query: 529  QIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIAR-KLALAQLRQESCPLPPPV 587
            ++ L    A+ +    ++ SL  +++ +  K  T++  + R   ALA++ +    L   V
Sbjct: 1669 RLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKV 1728

Query: 588  TDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQT 647
                         R   +A  Q SA L              +   L K     E + Q  
Sbjct: 1729 -------------RGLTEALAQSSASL---------NSTRDKNLHLQKALTACEHDRQVL 1766

Query: 648  QESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLRE---Q 704
            QE       +L+ ARQ   E+ ++++SL +++        Q L+ +VA++E +  E   Q
Sbjct: 1767 QE-------RLDAARQALSEARKQSSSLGEQV--------QTLRGEVADLELQRVEAEGQ 1811

Query: 705  LSDTERRLNEARREHAKAVVSLRQIQ--RRAAQEKERSQELRRLQEEARKEEGQRLARRL 762
            L      L + +   A A+ +++++Q  RR  QE+  S +    Q EA K E +R A R 
Sbjct: 1812 LQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALR- 1870

Query: 763  QELERDKNLMLATLQQ 778
              LE+D+  +  TL +
Sbjct: 1871 --LEKDRVALRRTLDK 1884



 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 159/760 (20%), Positives = 302/760 (39%), Gaps = 114/760 (15%)

Query: 170 LEGSQALSQQAEVIVRQLQELRR-LEEE---------------------VRLLRETSLQQ 207
           LE  +  +Q+   +VRQ  ELRR L+EE                     V+ L+   LQ 
Sbjct: 124 LEPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQY 183

Query: 208 KMRLEAQAMELEALARAEKAGRAEAEGLRAA--LAGAEVVRKNLEEGSQR--ELEEVQRL 263
           K R      +L      E++G  E + LR        E     LEE  QR   L +V  +
Sbjct: 184 KKRCSELEQQL-----LERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAM 238

Query: 264 HQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQREAELLRKQLSK 323
            +EQL     A++     +        +    LE R A         +RE E      S 
Sbjct: 239 LREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAA-------WRREEESFNAYFSN 291

Query: 324 TQEDLEAQVTLVENLRKYVGE----------QVPSEVHSQTWELERQKL-LETMQHLQED 372
               L      V   R+ V E          Q+  E+   +  ++   L L T   L E 
Sbjct: 292 EHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAES 351

Query: 373 R-DSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVF 431
           R ++      LLQ +++       L+E++L ++   SD  + + + +   L         
Sbjct: 352 RAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTEL--------G 403

Query: 432 ALMVQLKAQELEHSDSVKQLKGQVAS-----LQEKVTSQSQEQAILQRSLQDKA------ 480
             + +L+ Q LE     K L  ++ +     LQE+   ++++   LQ++L+D A      
Sbjct: 404 LAVKRLEKQNLEKDQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSD 463

Query: 481 AEVEVERMGA-----------KGLQLELSRAQEAR---------RRWQQQTASAEEQLRL 520
           +E  V+  G+           +GL  + + +   R         RR      S    L L
Sbjct: 464 SESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLAL 523

Query: 521 VVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQES 580
           + +A+   Q+ ++    + E +   L +L  +LS +  +   +   + R      LR ++
Sbjct: 524 IHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQR------LRDKT 577

Query: 581 CPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQ------QEVGRAREQGEAERQQLS 634
                   D   E+Q+LR     L  E    A  +Q      +E+ + RE+ +A +++L 
Sbjct: 578 DGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELR 637

Query: 635 KVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKV 694
           +   +LE+E +   +  A +  +LE + +  ++   + + L +EL + +E   +A  ++ 
Sbjct: 638 RQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQR- 696

Query: 695 AEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEE 754
                 L+ + ++    L +A     +  +S+ +++   A  ++   +L  L E   +++
Sbjct: 697 ----DMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDK 752

Query: 755 GQRLARRLQELERDKNLMLA---TLQQEGLLSRYKQQRLLTVLPSLLDKKKSVVSSPRPP 811
              L R + +LE +K+ +       +QE  ++R +Q+RL  +       ++ +  S R  
Sbjct: 753 -LDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVA 811

Query: 812 ECSASAPVAAAVPTRESIKGSLSVLLDDLQDLSEAISKEE 851
           E  A   +   +PT   ++   S L + L  LS  +S  E
Sbjct: 812 E-QAQEALEQQLPT---LRHERSQLQEQLAQLSRQLSGRE 847



 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 130/521 (24%), Positives = 214/521 (41%), Gaps = 74/521 (14%)

Query: 239 LAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKA-EGLEKSLSSLE 297
           LA A+ V   LE   Q  LE      ++ L +   A +  ++SL +   E + ++LS  E
Sbjct: 5   LARAQEVELTLETVIQT-LESSVLCQEKGLGARDLAQDAQITSLPALIREIVTRNLSQPE 63

Query: 298 TR---RAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQT 354
           +     A E   L   Q E +LL+++LS+  EDL AQ +  E     +     SE   Q 
Sbjct: 64  SPVLLPATEMASLLSLQEENQLLQQELSRV-EDLLAQ-SRAERDELAIKYNAVSERLEQA 121

Query: 355 WELERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELT--RKVQP---SD 409
             LE  +L       QE R  +  + EL +           LQEE+ +  RK+Q      
Sbjct: 122 LRLEPGEL-----ETQEPRGLVRQSVELRR----------QLQEEQASYRRKLQAYQEGQ 166

Query: 410 SLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQ 469
             + +  ++ Q  + +++++   L  QL    LE S  ++Q +     L++   SQ  E 
Sbjct: 167 QRQAQLVQRLQGKILQYKKRCSELEQQL----LERSGELEQQR-----LRDTEHSQDLES 217

Query: 470 AI--LQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSS 527
           A+  L+   Q  A+  +V  M    L+ +L +A  A +       +  E +R V N  + 
Sbjct: 218 ALIRLEEEQQRSASLAQVNAM----LREQLDQAGSANQ-------ALSEDIRKVTNDWTR 266

Query: 528 SQIWLETTMA----KVEGAAAQLPSLNNRLSYAVRKVHTIRGLIAR-----KLALAQLRQ 578
            +  LE   A    + E   A   + ++RL    R+V   R L++      +  L QL  
Sbjct: 267 CRKELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGG 326

Query: 579 ESCPLPPPVTDVSLELQQ-LREERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVA 637
           E       V +  L L   LR   +R +A L+  A L          Q + E Q   KV 
Sbjct: 327 ELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALL----------QAQLEEQLRDKVL 376

Query: 638 QQLEQELQQTQESLASLGLQLEVARQGQ-----QESTEEAASLRQELTQQQELYGQALQE 692
           ++ +   QQ Q  L    L   V   G      ++   E   + ++LT++ E       +
Sbjct: 377 REKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESLRLQ 436

Query: 693 KVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRA 733
           + A +ET   E L  T R L +A    +++ V L   +R A
Sbjct: 437 EQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTA 477



 Score = 56.6 bits (135), Expect = 1e-07
 Identities = 65/247 (26%), Positives = 112/247 (45%), Gaps = 32/247 (12%)

Query: 529 QIWLETTMAKVEGAA-AQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPV 587
           ++ LET +  +E +   Q   L  R      ++ ++  LI R++    L Q   P+  P 
Sbjct: 12  ELTLETVIQTLESSVLCQEKGLGARDLAQDAQITSLPALI-REIVTRNLSQPESPVLLPA 70

Query: 588 TDVSLELQQLREERNRLDAELQLSARLIQQEVGRARE---QGEAERQQLS----KVAQQL 640
           T+++  L  L+EE            +L+QQE+ R  +   Q  AER +L+     V+++L
Sbjct: 71  TEMA-SLLSLQEEN-----------QLLQQELSRVEDLLAQSRAERDELAIKYNAVSERL 118

Query: 641 EQELQ------QTQESLASLGLQLEVARQGQQESTEEAASLR--QELTQQQELYGQALQE 692
           EQ L+      +TQE    +   +E+ RQ Q+E       L+  QE  Q+Q    Q LQ 
Sbjct: 119 EQALRLEPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQG 178

Query: 693 KVAEVETR---LREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEE 749
           K+ + + R   L +QL +    L + R    +    L     R  +E++RS  L ++   
Sbjct: 179 KILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAM 238

Query: 750 ARKEEGQ 756
            R++  Q
Sbjct: 239 LREQLDQ 245



 Score = 31.6 bits (70), Expect = 3.3
 Identities = 39/150 (26%), Positives = 67/150 (44%), Gaps = 31/150 (20%)

Query: 138  RRLDTQRPQVTMWERDVSSDRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQELRRLEEEV 197
            R LD    +      D      E GR  R+  L G++    +A+   RQ+Q+L   E +V
Sbjct: 1880 RTLDKVEREKLRSHEDTVRLSAEKGRLDRT--LTGAELELAEAQ---RQIQQL---EAQV 1931

Query: 198  RLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQREL 257
             +L ++    ++ ++AQ  +LE         + E E LR+A A  E           R L
Sbjct: 1932 VVLEQSHSPAQLEVDAQQQQLEL--------QQEVERLRSAQAQTE-----------RTL 1972

Query: 258  EEVQRLHQEQLSSLTQAHEEALSSLTSKAE 287
            E  +R H++++  L    EE +S+L  + +
Sbjct: 1973 EARERAHRQRVRGL----EEQVSTLKGQLQ 1998


>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
            sapiens]
          Length = 1983

 Score =  118 bits (296), Expect = 2e-26
 Identities = 175/748 (23%), Positives = 303/748 (40%), Gaps = 112/748 (14%)

Query: 171  EGSQALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRA 230
            +  Q L ++ +    +L +L    E+ +LL     ++   L+A+A ELE    AE+A RA
Sbjct: 1120 QDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARA 1179

Query: 231  EAEGLRA-ALAGAEVVRKNLEEGS--------------------QRELEEVQRLHQEQLS 269
              E  RA A    E + + LEE                      +RELEE    H+  ++
Sbjct: 1180 RVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVA 1239

Query: 270  SLTQAHEEALSSLTSKAEGLEKSLSSLETRRAG---EAKELA---EAQREAELLRKQLSK 323
            +L +   E  + L  + + L++    LE  ++    E  +LA   E    A+   ++L +
Sbjct: 1240 ALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCR 1299

Query: 324  TQEDLEAQVTL-VENLRKYVGEQVPSEVHSQTWELERQKLLE---------------TMQ 367
            T ED  ++  + VE L++ + +        QT   E  +LLE                 Q
Sbjct: 1300 TYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQ 1359

Query: 368  HLQEDRDSLHATAE---LLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLN 424
             L+E R  L   ++    L   VQ+L H   L  E+   + +    L+     K  + + 
Sbjct: 1360 SLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQ-RLLSKANAEVA 1418

Query: 425  RWREKVFALMVQLKAQELEHSDSVKQLKGQ-----VASLQEKVTSQSQEQAILQRSLQDK 479
            +WR K  A  +Q + +ELE +     L+ Q     V +   K +S  + +  LQ   +D 
Sbjct: 1419 QWRSKYEADAIQ-RTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDV 1477

Query: 480  AAEVEVERMGAKGL---QLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTM 536
              E+E     A  L   Q  L RA E RRR +++                  Q  LE   
Sbjct: 1478 TLELERATSAAAALDKKQRHLERALEERRRQEEE-----------------MQRELEAAQ 1520

Query: 537  AKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQ 596
             +  G   +L  L +    A+  + T+      K     L++E   L   V+     +Q+
Sbjct: 1521 RESRGLGTELFRLRHGHEEALEALETL------KRENKNLQEEISDLTDQVSLSGKSIQE 1574

Query: 597  LREERNRLDAE-LQLSARLIQQEVGRAREQGEAERQQ--LSKVAQQLEQELQQTQESLAS 653
            L + +  L+ E  ++ A L + E     E+ +  R Q  LS+V  +++++L +  E  A+
Sbjct: 1575 LEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECAN 1634

Query: 654  LGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLN 713
            L       R+  Q + E   SL+  L  +     +AL+     ++ ++   L+D E +L 
Sbjct: 1635 L-------RRNHQRAVE---SLQASLDAETRARNEALR-----LKKKMEGDLNDLELQLG 1679

Query: 714  EARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLML 773
             A R+  +A  + R +Q +  +E+    E +RL  E   E+ Q L RR   L  +   + 
Sbjct: 1680 HATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELH-EQAQALERRASLLAAELEELR 1738

Query: 774  ATLQQEGLLSRYKQQRLLTVL----------PSLLDKKKSVVSSPRPPECSASAPVAAAV 823
            A L+Q     R  +Q LL               LL++KK + +         S  V  A 
Sbjct: 1739 AALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEAD----LAQLSGEVEEAA 1794

Query: 824  PTRESIKGSLSVLLDDLQDLSEAISKEE 851
              R   +      + D   ++E + KE+
Sbjct: 1795 QERREAEEKAKKAITDAAMMAEELKKEQ 1822



 Score =  103 bits (256), Expect = 9e-22
 Identities = 158/654 (24%), Positives = 268/654 (40%), Gaps = 80/654 (12%)

Query: 209  MRLEAQAMELEALARAEK---AGRAEAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLHQ 265
            M+L  +   L   A+AE+   A RAE  GLR ALA AE  R+ LEE      +E     +
Sbjct: 879  MKLFFKMKPLLRSAQAEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQE-----K 933

Query: 266  EQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQREAELLRKQLSKTQ 325
              L+   QA ++ L+    +   L KS   LE    G+ KEL+E   + E +   L+  +
Sbjct: 934  NDLALQLQAEQDNLADAEERCHLLIKSKVQLE----GKVKELSERLEDEEEVNADLAARR 989

Query: 326  EDLEAQVT-LVENLRKYVGEQVPSEVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQ 384
              LE + T L +++         +E   Q  E + + L E M  L E    L    + LQ
Sbjct: 990  RKLEDECTELKKDIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQ 1049

Query: 385  VRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEH 444
               Q     L  +E+ ++   +    LE +             E +   + Q K   ++ 
Sbjct: 1050 EAHQQALGDLQAEEDRVSALTKAKLRLEQQV------------EDLECSLEQEKKLRMDT 1097

Query: 445  SDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEAR 504
              + ++L+G +   QE V   +Q++  L+  L+ K +E+    +  +  QL  ++ Q+  
Sbjct: 1098 ERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKI 1157

Query: 505  RRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYA-VRKVHTI 563
            +  Q +    EE+L     A  +++  +E   A+   AA +L  L+ RL  A        
Sbjct: 1158 KELQARAEELEEEL----EAERAARARVEKQRAE---AARELEELSERLEEAGGASAGQR 1210

Query: 564  RGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAR 623
             G   R+  L +LR+E            LE   LR E           A L +++   A 
Sbjct: 1211 EGCRKREAELGRLRRE------------LEEAALRHEAT--------VAALRRKQAEGAA 1250

Query: 624  EQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQ 683
            E GE +   L +V Q+LE+E  + +  +  L   +E   +  + S E+     ++   + 
Sbjct: 1251 ELGE-QVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRA-KASAEKLCRTYEDQLSEA 1308

Query: 684  ELYGQALQEKVAEVET---RLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERS 740
            ++  + LQ ++A+  T   RL+ +  +  R L E           + Q+ R  A   +  
Sbjct: 1309 KIKVEELQRQLADASTQRGRLQTESGELSRLLEEKE-------CLISQLSRGKALAAQSL 1361

Query: 741  QELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEGLLSRYKQQRLLTVLPSLLDK 800
            +ELRR  EE  K +   LA  +Q L  D +L+    ++E              L  LL K
Sbjct: 1362 EELRRQLEEESKAK-SALAHAVQALRHDCDLLREQHEEEA--------EAQAELQRLLSK 1412

Query: 801  KKSVVSSPRPPECSASAPVAAAVPTRESIKGSLSVLLDDLQDLSEAISKEEAVC 854
              + V+  R      S   A A+   E ++ +   L   LQ+  E +    A C
Sbjct: 1413 ANAEVAQWR------SKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKC 1460



 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 149/639 (23%), Positives = 265/639 (41%), Gaps = 65/639 (10%)

Query: 171  EGSQALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRA 230
            E S+ L  + EV        R+LE+E   L++     K+ L     E +A     K    
Sbjct: 970  ELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTLAKAEKEKQATENKVKNLTE 1029

Query: 231  EAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLE 290
            E   L  ++A     +K L+E            HQ+ L  L QA E+ +S+LT     LE
Sbjct: 1030 EMAALDESVARLTKEKKALQEA-----------HQQALGDL-QAEEDRVSALTKAKLRLE 1077

Query: 291  KSLSSLETRRAGEAKELAEAQREAELLRKQLSKTQEDL----EAQVTLVENLRKYVGEQV 346
            + +  LE     E K   + +R    L   L  TQE +    + +  L E L+K   E  
Sbjct: 1078 QQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELS 1137

Query: 347  PSEVHSQTWEL---ERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTR 403
               +  +  +L   + QK ++ +Q   E+ +         + RV+      A + EEL+ 
Sbjct: 1138 QLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSE 1197

Query: 404  KVQPSDSL---EPEFTRKCQSLLNRWREKVFALMVQ----LKAQELEHSDSVKQLKGQVA 456
            +++ +      + E  RK ++ L R R ++    ++    + A   + ++   +L  QV 
Sbjct: 1198 RLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVD 1257

Query: 457  SLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEE 516
            SLQ       +E++ L+  + D AA VE            L+RA+          ASAE+
Sbjct: 1258 SLQRVRQKLEKEKSELRMEVDDLAANVET-----------LTRAK----------ASAEK 1296

Query: 517  QLRLVVNAVSSSQIWLETTMAKVEGAAAQ---LPSLNNRLSYAVRKVHTIRGLIARKLAL 573
              R   + +S ++I +E    ++  A+ Q   L + +  LS  + +   +   ++R  AL
Sbjct: 1297 LCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKAL 1356

Query: 574  A-----QLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEA 628
            A     +LR++        + ++  +Q LR + + L  + +  A   Q E+ R   +  A
Sbjct: 1357 AAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAE-AQAELQRLLSKANA 1415

Query: 629  E-RQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASL-RQELTQQQELY 686
            E  Q  SK      Q  ++ +E+   L L+L+ A +G + +  + +SL + +L  Q E  
Sbjct: 1416 EVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESE 1475

Query: 687  GQALQ-EKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRR 745
               L+ E+       L ++    ER L E RR+  +    L   QR +         LR 
Sbjct: 1476 DVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRH 1535

Query: 746  LQEEA------RKEEGQRLARRLQELERDKNLMLATLQQ 778
              EEA       K E + L   + +L    +L   ++Q+
Sbjct: 1536 GHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQE 1574



 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 135/649 (20%), Positives = 259/649 (39%), Gaps = 98/649 (15%)

Query: 132  HQDVSERRLDTQR------PQVTMWERDVSSDRQEPGRRGRSWGLEGSQALSQQAEVIVR 185
            H++ +E + + QR       +V  W     +D            ++ ++ L +  + +  
Sbjct: 1396 HEEEAEAQAELQRLLSKANAEVAQWRSKYEAD-----------AIQRTEELEEAKKKLAL 1444

Query: 186  QLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVV 245
            +LQE     E       +  + K+RL+ ++ ++        +  A  +  +  L  A   
Sbjct: 1445 RLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEE 1504

Query: 246  RKNLEEGSQRELEEVQRLHQ---EQLSSLTQAHEEALSSL-TSKAE--GLEKSLSSLETR 299
            R+  EE  QRELE  QR  +    +L  L   HEEAL +L T K E   L++ +S L  +
Sbjct: 1505 RRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQ 1564

Query: 300  RAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELER 359
             +   K + E ++  + L  + S+ Q  LE                            E 
Sbjct: 1565 VSLSGKSIQELEKTKKALEGEKSEIQAALE----------------------------EA 1596

Query: 360  QKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKC 419
            +  LE      E+  +L    EL QV+             E+ RK+   D        +C
Sbjct: 1597 EGALEL-----EETKTLRIQLELSQVKA------------EVDRKLAEKD-------EEC 1632

Query: 420  QSLLNRWREKVFALMVQLKAQELEHSDSV---KQLKGQVASLQEKV---TSQSQEQAILQ 473
             +L    +  V +L   L A+    ++++   K+++G +  L+ ++   T Q+ E     
Sbjct: 1633 ANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAAT 1692

Query: 474  RSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLE 533
            R +Q +  E +  R   + L  EL    +A  R     A+  E+LR  +     S+   E
Sbjct: 1693 RLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLAE 1752

Query: 534  TTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKL--ALAQLRQESCPLPPPVTDVS 591
              + +       L S N  L    +K+      ++ ++  A  + R+        +TD +
Sbjct: 1753 QELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAA 1812

Query: 592  LELQQLREERN------RLDAELQLSARLIQQEVGRAREQ----GEAERQQLSKVAQQLE 641
            +  ++L++E++      R+   L+ + R +Q  +  A +     G+ + Q+L    ++LE
Sbjct: 1813 MMAEELKKEQDTSAHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELE 1872

Query: 642  QELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRL 701
             EL   Q+  A     +    +  +E   +A   R+ L + Q+L  + LQ KV       
Sbjct: 1873 AELDAEQKKHAEALKGVRKHERRVKELAYQAEEDRKNLARMQDLVDK-LQSKVKS----Y 1927

Query: 702  REQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEA 750
            + Q  + E++ N    ++ KA   L   + RA   + ++ +LR    +A
Sbjct: 1928 KRQFEEAEQQANTNLAKYRKAQHELDDAEERADMAETQANKLRARTRDA 1976



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 135/627 (21%), Positives = 249/627 (39%), Gaps = 69/627 (11%)

Query: 288  GLEKSLSSLETRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVP 347
            GL   L  L  +R  +   L +A+    L+R +  +     +A  T+  N+R +      
Sbjct: 817  GLLGVLEELRDQRLAKVLTLLQARSRGRLMRLEYQRLLGGRDALFTIQWNIRAF------ 870

Query: 348  SEVHSQTWELERQKLLETMQHLQEDRDSLHATAEL---------LQVRVQSL--THILAL 396
            + V + +W     K+   ++  Q + +     AEL          + + Q L  TH+   
Sbjct: 871  NAVKNWSWMKLFFKMKPLLRSAQAEEELAALRAELRGLRGALAAAEAKRQELEETHVSIT 930

Query: 397  QEE-ELTRKVQPSDSLEPEFTRKCQSLLN---RWREKVFALMVQLKAQELEHS------- 445
            QE+ +L  ++Q       +   +C  L+    +   KV  L  +L+ +E  ++       
Sbjct: 931  QEKNDLALQLQAEQDNLADAEERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRR 990

Query: 446  ---DSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQE 502
               D   +LK  +  L+  +    +E+   +  +++   E+         L  E    QE
Sbjct: 991  KLEDECTELKKDIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQE 1050

Query: 503  ARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHT 562
            A ++      + E++    V+A++ +++ LE  +  +E +  Q   L      A RK+  
Sbjct: 1051 AHQQALGDLQAEEDR----VSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLE- 1105

Query: 563  IRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLR---EERNRLDAELQLSARLIQQEV 619
               L   + ++A   Q+   L   +     EL QL    E+   L A++Q   + +Q   
Sbjct: 1106 -GDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARA 1164

Query: 620  GRAREQGEAERQQLSKVAQQ---LEQELQQTQESLASLGLQLEVARQGQQESTEEAASLR 676
                E+ EAER   ++V +Q     +EL++  E L   G      R+G ++   E   LR
Sbjct: 1165 EELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLR 1224

Query: 677  QELTQ---QQELYGQALQEKVAEVETRLREQLSDTER---RLNEARREHAKAVVSLRQIQ 730
            +EL +   + E    AL+ K AE    L EQ+   +R   +L + + E    V  L    
Sbjct: 1225 RELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANV 1284

Query: 731  RRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQE-GLLSRYKQQR 789
                + K  +++L R  E+ +  E +     LQ    D +     LQ E G LSR     
Sbjct: 1285 ETLTRAKASAEKLCRTYED-QLSEAKIKVEELQRQLADASTQRGRLQTESGELSR----- 1338

Query: 790  LLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGSLSVLLDDLQ------DL 843
                   LL++K+ ++S     +  A+  +       E    + S L   +Q      DL
Sbjct: 1339 -------LLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDL 1391

Query: 844  SEAISKEEAVCQGDNLDRCSSSNPQMS 870
                 +EEA  Q +     S +N +++
Sbjct: 1392 LREQHEEEAEAQAELQRLLSKANAEVA 1418


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score =  115 bits (287), Expect = 2e-25
 Identities = 172/695 (24%), Positives = 288/695 (41%), Gaps = 87/695 (12%)

Query: 133  QDVSERRLDTQRPQVTMWERDVSSDRQEPGRRGRSWGLEGSQALSQQA--------EVIV 184
            +D  +R  +T+R +    ++ +  D++E  RR R   LE  +   QQ         E   
Sbjct: 455  RDWLKREEETERHEQERRKQQLKRDQEEE-RRERWLKLEEEERREQQERREQQLRREQEE 513

Query: 185  RQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEV 244
            R+ Q L+R EEE RL +    +Q++R E Q    E L + E+  R E E     L   + 
Sbjct: 514  RREQRLKRQEEEERLQQRLRSEQQLRRE-QEERREQLLKREEEKRLEQERREQRLKREQE 572

Query: 245  VR-----KNLEEGSQREL--------------EEVQRLHQE----QLSSLTQAHEEALSS 281
             R     K  EE  Q+ L              EEV+RL QE    Q     +  EE    
Sbjct: 573  ERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQ 632

Query: 282  LTSKAEGLEKSLSSLETRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKY 341
            L    E  E+    L   +    ++  + + E E L ++L +  E+   +  L E  ++ 
Sbjct: 633  LLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQ 692

Query: 342  VGEQVPSEVHSQTWELE-----RQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILAL 396
              E++ S +    W+LE     RQ  + +    QE +       E  + R   L      
Sbjct: 693  ARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQW---- 748

Query: 397  QEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVA 456
            QEEE   + Q  +    +FT + Q+      EK      +L A+        +QL+ +  
Sbjct: 749  QEEERAHRQQQEEEQRRDFTWQWQA-----EEKSERGRQRLSARPPLREQRERQLRAEER 803

Query: 457  SLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEE 516
              +E+     +E+   QR  Q +  E E++ +  +    +L R + A++  +++    E+
Sbjct: 804  QQREQRFLPEEEEKE-QRRRQRREREKELQFLEEEE---QLQRRERAQQLQEEEDGLQED 859

Query: 517  QLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQL 576
            Q R         Q W             QL     R      + HT   L A+     QL
Sbjct: 860  QERRRSQEQRRDQKW-----------RWQLEEERKR------RRHT---LYAKPALQEQL 899

Query: 577  RQESCPLPPPVTDVSLELQQLREERNRLDAELQL--SARLIQQEVGRAREQGEAERQQLS 634
            R+E   L     ++  E    RE+R R + E Q     +L Q+E    RE+ E  R+Q  
Sbjct: 900  RKEQQLLQEEEEELQREE---REKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQER 956

Query: 635  KVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKV 694
            +   + +++LQQ +E L  LG + E  R+ ++E         +EL Q++E   Q L+E  
Sbjct: 957  ERQYRKDKKLQQKEEQL--LGEEPEKRRRQEREKKYRE---EEELQQEEE---QLLRE-- 1006

Query: 695  AEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEE 754
             E E R R++     R+ +E ++E  + +   R+ +R   +E++  +E    QEE +   
Sbjct: 1007 -EREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLG 1065

Query: 755  GQRLARRLQELERDKNLMLATLQQEGLLSRYKQQR 789
             +R  RR QELER         Q+E  L R + ++
Sbjct: 1066 EERETRRRQELERQYRKEEELQQEEEQLLREEPEK 1100



 Score = 97.8 bits (242), Expect = 4e-20
 Identities = 151/674 (22%), Positives = 269/674 (39%), Gaps = 54/674 (8%)

Query: 137 ERRLDTQRPQVTMWER-DVSSDRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQELRRLEE 195
           +R L  +  Q+   ER ++  +RQE  ++         Q L ++ ++  +Q +E R  +E
Sbjct: 268 QRELQEEEEQLRKLERQELRRERQEEEQQ--------QQRLRREQQLRRKQEEERREQQE 319

Query: 196 EVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQR 255
           E R  +E   QQ+ R E Q    +   R ++  R + E  R      E   +  E+  +R
Sbjct: 320 ERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRR 379

Query: 256 E--LEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQRE 313
           E  L   Q+L +EQ     Q           +    E+ L   +  R  + +E  E + E
Sbjct: 380 EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHE 439

Query: 314 AELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQ---KLLETMQHLQ 370
            E   ++L + QE+    +   E   ++  E+   ++     E  R+   KL E  +  Q
Sbjct: 440 QERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQ 499

Query: 371 EDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKV 430
           ++R       E  + R Q L      +EE L ++++    L  E   + + LL R  EK 
Sbjct: 500 QERREQQLRREQEERREQRLKR--QEEEERLQQRLRSEQQLRREQEERREQLLKREEEKR 557

Query: 431 FALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGA 490
                + +  + E  +   QL  +    +++   + QE+ + QR  +++   +E E    
Sbjct: 558 LEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQE---- 613

Query: 491 KGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLN 550
           +  +  L R +    R QQ   S E++ R         Q   E  + + E          
Sbjct: 614 ERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEE--------E 665

Query: 551 NRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQL 610
            RL   +++ H       R+  LA+  QE           + E  + R  + +   E + 
Sbjct: 666 ERLEQRLKREHEEE---RREQELAEEEQEQ----------ARERIKSRIPKWQWQLESEA 712

Query: 611 SARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEVAR-----QGQ 665
            AR  +      +++G+  RQ+  +  ++ E ELQ  +E  A    Q E  R     Q Q
Sbjct: 713 DARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQ 772

Query: 666 QESTEEAA----SLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHAK 721
            E   E      S R  L +Q+E   +A + +  E      E+  +  RR    R +  +
Sbjct: 773 AEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQ 832

Query: 722 AVVSLRQIQR--RAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQE 779
            +    Q+QR  RA Q +E    L+  QE  R +E +R  +   +LE ++     TL  +
Sbjct: 833 FLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAK 892

Query: 780 GLLSRY--KQQRLL 791
             L     K+Q+LL
Sbjct: 893 PALQEQLRKEQQLL 906



 Score = 97.1 bits (240), Expect = 6e-20
 Identities = 154/695 (22%), Positives = 281/695 (40%), Gaps = 91/695 (13%)

Query: 137 ERRLDTQRPQVTMWERDVSSDRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQELRRLEEE 196
           ERR   +  +     R+   +R+E   R         Q   +Q E   R+ Q+LRR +EE
Sbjct: 313 ERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEE--RREQQLRREQEE 370

Query: 197 VRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQRE 256
            R  ++   +Q++R E Q    + L R ++                  +R+  +   +++
Sbjct: 371 ERREQQLRREQQLRREQQLRREQQLRREQQ------------------LRREQQLRREQQ 412

Query: 257 LEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQR-EAE 315
           L   Q+L +EQ   L +  EE       + E  E+ L   +  R    K   E +R E E
Sbjct: 413 LRREQQLRREQ--QLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQE 470

Query: 316 LLRKQLSKTQED--LEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQHLQEDR 373
             ++QL + QE+   E  + L E  R+   E+   ++  +  E  R++ L+  +  +  +
Sbjct: 471 RRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQ-EERREQRLKRQEEEERLQ 529

Query: 374 DSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNR-------- 425
             L +  +L + + +    +L  +EE+   + +    L+ E   +   LL R        
Sbjct: 530 QRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQR 589

Query: 426 -WREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVE 484
             RE+   L  +LK +E+E    ++Q + +   L+ +   + + Q +L+   Q++  + +
Sbjct: 590 LKREQEERLEQRLKREEVER---LEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQ 646

Query: 485 VERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAA 544
           + R   +  +  L R +E  R  Q+     EE+ R    A    +   E   +++     
Sbjct: 647 LRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQW 706

Query: 545 QLPS-LNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREE--- 600
           QL S  + R S    +     G   R+    + R+    L     + +   QQ  E+   
Sbjct: 707 QLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRD 766

Query: 601 --------------RNRLDA--------ELQLSARLIQQEVGR------AREQGEAERQQ 632
                         R RL A        E QL A   QQ   R       +EQ   +R++
Sbjct: 767 FTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRRE 826

Query: 633 LSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQ----------- 681
             K  Q LE+E Q  +   A    QL+    G QE  E   S  Q   Q           
Sbjct: 827 REKELQFLEEEEQLQRRERAQ---QLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERK 883

Query: 682 --QQELYGQ-ALQEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKE 738
             +  LY + ALQE++ + +  L+E+  + +R   E RR   +     RQ +     ++E
Sbjct: 884 RRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQE----RQYREEEQLQQE 939

Query: 739 RSQELRRLQEEARKEEGQRLARRLQELERDKNLML 773
             Q LR  +E+ R++E +R  R+ ++L++ +  +L
Sbjct: 940 EEQLLREEREKRRRQERERQYRKDKKLQQKEEQLL 974



 Score = 92.8 bits (229), Expect = 1e-18
 Identities = 147/627 (23%), Positives = 266/627 (42%), Gaps = 65/627 (10%)

Query: 170  LEGSQALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGR 229
            L G Q    + +   R  Q  R   EE +L RE   + K R + ++ E + L R E+  +
Sbjct: 1270 LLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRR-DRKSQEEKQLLREEREEK 1328

Query: 230  AEAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGL 289
               +         E + +  EE   R  E  ++  +E+L      H+E       + + L
Sbjct: 1329 RRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELR-----HQEQGRKFLEEEQRL 1383

Query: 290  EKSLSSLETRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSE 349
             +     E +   E ++L   +RE +L + +  K +E+ E Q++  E  RK+  E+   +
Sbjct: 1384 RRQ--ERERKFLKEEQQLRCQEREQQLRQDRDRKFREE-EQQLSRQERDRKFREEE--QQ 1438

Query: 350  VHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSD 409
            V  Q  E ER+ L E  Q  QE         +LLQ R          +E++L R+ +   
Sbjct: 1439 VRRQ--ERERKFLEEEQQLRQERHRKFREEEQLLQER----------EEQQLHRQERDRK 1486

Query: 410  SLEPEFTRKCQSLLNRWREKVFALMVQLKAQE-----LEHSDSVKQLKGQVASLQEKVTS 464
             LE E   + Q    ++RE+      +L++QE     LE    + + + Q   LQE+   
Sbjct: 1487 FLEEEQQLRRQERDRKFREQ------ELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQL 1540

Query: 465  QSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARR-RWQQQTASAEEQLRLVVN 523
            + QE+   +R  +D+    E E++  +  + +LSR +  R+ R ++Q    +EQ R  + 
Sbjct: 1541 RRQERGQQRRQDRDRKFREE-EQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFME 1599

Query: 524  AVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPL 583
                     E  + + EG       L        R+   +      +    Q R      
Sbjct: 1600 D--------EQQLRRQEGQQ----QLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLE 1647

Query: 584  PPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQE 643
              P        QQLR +R+R   E        ++++ +  E+ +  RQ+  +  ++ EQ+
Sbjct: 1648 EEPQLRRQEREQQLRHDRDRKFRE--------EEQLLQEGEEQQLRRQERDRKFREEEQQ 1699

Query: 644  LQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLRE 703
            L++ +     L  + ++ RQ  +    E   LRQE T+Q++L  Q    K+ E E +LR 
Sbjct: 1700 LRRQERERKFLQEEQQLRRQELERKFREEEQLRQE-TEQEQLRRQERYRKILE-EEQLRP 1757

Query: 704  QLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQ 763
            +  + + R  E  R+  +      Q+++   +++ RSQE  R   + R+EE  R  R  Q
Sbjct: 1758 EREEQQLRRQERDRKFREE----EQLRQEREEQQLRSQESDR---KFREEEQLRQEREEQ 1810

Query: 764  ELERDKNLMLATLQQEGLLSRYKQQRL 790
            +L   +       ++E L    ++QRL
Sbjct: 1811 QLRPQQRDGKYRWEEEQLQLEEQEQRL 1837



 Score = 91.3 bits (225), Expect = 4e-18
 Identities = 165/677 (24%), Positives = 278/677 (41%), Gaps = 103/677 (15%)

Query: 159 QEPGRRGRSWGLEGSQALSQQAEVIVRQLQELRRLEEEVRLLRETSL-------QQKMRL 211
           +EPG+R R    E  + L++  E    Q ++  RLE+  R  R+  L       Q++   
Sbjct: 131 EEPGQRRRQKRQEQERELAEGEE----QSEKQERLEQRDRQRRDEELWRQRQEWQEREER 186

Query: 212 EAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSL 271
            A+  +L++    E     + E LR      E+ RK  EE  Q+  E   R+ QE+    
Sbjct: 187 RAEEEQLQSCKGHETEEFPDEEQLRRREL-LELRRKGREEKQQQRRERQDRVFQEEEEKE 245

Query: 272 TQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQ 331
            +  E  L          E+ L   E +R  E +E  E  R+ E  R++L + +++ E Q
Sbjct: 246 WRKRETVLRKE-------EEKLQEEEPQRQRELQEEEEQLRKLE--RQELRRERQEEEQQ 296

Query: 332 VTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQSLT 391
              +   ++   +Q       Q    E+Q+  E     QE+R       E  + R Q L 
Sbjct: 297 QQRLRREQQLRRKQEEERREQQEERREQQERREQ----QEERREQQLRREQEERREQQLR 352

Query: 392 HILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQL 451
                ++EE  R+ Q     E E  R+ Q L    RE+      QL+ ++    +  +QL
Sbjct: 353 R----EQEEERREQQLRREQEEE--RREQQLR---REQQLRREQQLRREQQLRRE--QQL 401

Query: 452 KGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQT 511
           + +    +E+   + Q+    Q+  +++  E   ++   +  +  L R QE RR W ++ 
Sbjct: 402 RREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKR- 460

Query: 512 ASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKL 571
              EE                ET   + E    QL                      R+ 
Sbjct: 461 ---EE----------------ETERHEQERRKQQLKRDQEE---------------ERRE 486

Query: 572 ALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAERQ 631
              +L +E             E Q+ RE++ R + E +   RL +QE     +Q     Q
Sbjct: 487 RWLKLEEEE----------RREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQ 536

Query: 632 QLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQAL- 690
           QL +  ++  ++L + +E       +LE  R+ Q+   E+     Q L +++E   Q L 
Sbjct: 537 QLRREQEERREQLLKREEE-----KRLEQERREQRLKREQEERRDQLLKREEERRQQRLK 591

Query: 691 QEKVAEVETRLR----EQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRL 746
           +E+   +E RL+    E+L   ERR    +RE  +     +Q+ +   QE+ R Q+LRR 
Sbjct: 592 REQEERLEQRLKREEVERLEQEERREQRLKREEPEE-ERRQQLLKSEEQEERRQQQLRRE 650

Query: 747 QEE------ARKEEGQRLARRL--QELERDKNLMLATLQQEGLLSRYKQQ--RLLTVLPS 796
           Q+E       R+EE +RL +RL  +  E  +   LA  +QE    R K +  +    L S
Sbjct: 651 QQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLES 710

Query: 797 LLDKKKS-VVSSPRPPE 812
             D ++S V S PR  E
Sbjct: 711 EADARQSKVYSRPRKQE 727



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 170/711 (23%), Positives = 285/711 (40%), Gaps = 95/711 (13%)

Query: 133 QDVSERRLDTQRPQVTMW-ERDVSSDRQEPGRRG----RSWGLEGSQALSQQAEVIVRQL 187
           Q+  ERR + ++ Q     E +   D ++  RR     R  G E  Q   ++ +  V Q 
Sbjct: 181 QEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQE 240

Query: 188 QELRR-------LEEEVRLLRETSLQQKMRLEAQAMELEALARAE-KAGRAEAEGLRAAL 239
           +E +        L +E   L+E   Q++  L+ +  +L  L R E +  R E E  +  L
Sbjct: 241 EEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRL 300

Query: 240 AGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETR 299
              + +R+  EE  +RE +E +R  QE+     +  E+ L     +    +      E R
Sbjct: 301 RREQQLRRKQEE-ERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEER 359

Query: 300 RAGE-AKELAEAQREAELLRKQLSKTQEDL--EAQVTLVENLRKYVGEQVPSEVHSQTWE 356
           R  +  +E  E +RE +L R+Q  + ++ L  E Q+   + LR+   +Q+  E      +
Sbjct: 360 REQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRR--EQQLRRE-----QQ 412

Query: 357 LERQKLLETMQHL-QEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEF 415
           L R++ L   Q L +E  +  H      + R Q L      QEE      +  ++   E 
Sbjct: 413 LRREQQLRREQQLRREQEEERHEQKHEQERREQRLKR---EQEERRDWLKREEETERHEQ 469

Query: 416 TRKCQSL--------LNRW--------REKVFALMVQLKAQELEHSDSVKQLKGQVASLQ 459
            R+ Q L          RW        RE+      QL+ ++ E  +   + + +   LQ
Sbjct: 470 ERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQ 529

Query: 460 EKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARR--------RWQQQT 511
           +++ S+ Q +   +   +      E +R+  +  +  L R QE RR          +QQ 
Sbjct: 530 QRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQR 589

Query: 512 ASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKL 571
              E++ RL        Q      + ++E    +   L        R+   ++     + 
Sbjct: 590 LKREQEERL-------EQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEER 642

Query: 572 ALAQLRQESCPLPPPVTDVSLELQQLREER-NRLDAELQLSARLIQQEVGRAREQGEAER 630
              QLR+E               Q+ RE+R  R + E +L  RL ++     REQ  AE 
Sbjct: 643 RQQQLRREQ--------------QERREQRLKREEEEERLEQRLKREHEEERREQELAEE 688

Query: 631 QQ----------LSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELT 680
           +Q          + K   QLE E    Q  + S   + E  R+ Q++  EE    R+   
Sbjct: 689 EQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQ--EEKRRRRESEL 746

Query: 681 QQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERS 740
           Q QE      Q++  E       Q    E+  +E  R+   A   LR+ + R  + +ER 
Sbjct: 747 QWQEEERAHRQQQEEEQRRDFTWQWQAEEK--SERGRQRLSARPPLREQRERQLRAEERQ 804

Query: 741 Q-ELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEGLLSRYKQQRL 790
           Q E R L EE  KE+     RR Q  ER+K L     ++E L  R + Q+L
Sbjct: 805 QREQRFLPEEEEKEQ-----RRRQRREREKELQFLE-EEEQLQRRERAQQL 849



 Score = 86.7 bits (213), Expect = 9e-17
 Identities = 160/678 (23%), Positives = 275/678 (40%), Gaps = 87/678 (12%)

Query: 137  ERRLDTQRPQVTMWERDVSSDRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQELRRLEEE 196
            ERR   QR +    E  +  + Q+  +R      E  Q L ++ E   R+ +  R+  EE
Sbjct: 1282 ERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREE 1341

Query: 197  VRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQRE 256
             +LL+E   Q   R E      E   R ++ GR   E     L   E  RK L+E  Q  
Sbjct: 1342 EQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEE-EQRLRRQERERKFLKEEQQLR 1400

Query: 257  L----------------EEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKS--LSSLET 298
                             EE Q+L +++     +  E+ +     + + LE+   L     
Sbjct: 1401 CQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERH 1460

Query: 299  RRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELE 358
            R+  E ++L + + E +L R++  +   + E Q+   E  RK+  +++ S+      E E
Sbjct: 1461 RKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQ------EPE 1514

Query: 359  RQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRK 418
            R K LE  Q L   +       E  Q+R Q        + ++  RK +  + L  E  R+
Sbjct: 1515 R-KFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQ---QRRQDRDRKFREEEQLRQE--RE 1568

Query: 419  CQSLLNRWREKVFALMVQ-LKAQE-----LEHSDSVKQLKGQVASLQEKVTSQSQEQAIL 472
             Q L  + R++ F L  Q ++ QE     +E    +++ +GQ    QE+     +++ +L
Sbjct: 1569 EQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLL 1628

Query: 473  QRSLQDKAAEVEVERMGAKGL-QLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIW 531
            Q   + +    E +R   +   QL     ++  R  + +    EEQL   +      Q+ 
Sbjct: 1629 QEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQL---LQEGEEQQLR 1685

Query: 532  LETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALA-QLRQESCPLPPPVTDV 590
             +    K      QL        +   +    R  + RK     QLRQE+          
Sbjct: 1686 RQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQET---------- 1735

Query: 591  SLELQQLR-EERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQE 649
              E +QLR +ER R   E        ++++   RE+ +  RQ+  +  ++ EQ  Q+ +E
Sbjct: 1736 --EQEQLRRQERYRKILE--------EEQLRPEREEQQLRRQERDRKFREEEQLRQEREE 1785

Query: 650  SLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTE 709
                     ++  Q       E   LRQE  ++Q+L  Q    K    E +L  QL + E
Sbjct: 1786 Q--------QLRSQESDRKFREEEQLRQE-REEQQLRPQQRDGKYRWEEEQL--QLEEQE 1834

Query: 710  RRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARK---EEGQRLAR---RLQ 763
            +RL + R    +A       ++ A QEK R +E    QEE +K   E  ++L     R Q
Sbjct: 1835 QRLRQERDRQYRAE------EQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQ 1888

Query: 764  ELERDKNLMLATLQ-QEG 780
            + E  ++  +  ++ QEG
Sbjct: 1889 QKEEQRHRQVGEIKSQEG 1906



 Score = 81.3 bits (199), Expect = 4e-15
 Identities = 154/642 (23%), Positives = 255/642 (39%), Gaps = 71/642 (11%)

Query: 137  ERRLDTQRPQVTMWERDVSSDRQEPGRRG--RSWGLEGSQALSQQAEVIVRQLQELRRLE 194
            E+RL  + P+    ++ + S+ QE  R+   R    E  +   ++ E   R  Q L+R  
Sbjct: 617  EQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREH 676

Query: 195  EEVR----LLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRKNLE 250
            EE R    L  E   Q + R++++  + +    +E   R      R      +  R+  E
Sbjct: 677  EEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQE 736

Query: 251  EGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAEA 310
            E  +R   E+Q   +E+ +   Q  EE     T + +  EKS      R+   A+     
Sbjct: 737  EKRRRRESELQ-WQEEERAHRQQQEEEQRRDFTWQWQAEEKSERG---RQRLSARPPLRE 792

Query: 311  QREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQ-KLLETMQHL 369
            QRE +L  ++  + ++    +    E  R+   E+   E   Q  E E Q +  E  Q L
Sbjct: 793  QRERQLRAEERQQREQRFLPEEEEKEQRRRQRRER---EKELQFLEEEEQLQRRERAQQL 849

Query: 370  QEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEP---EFTRKCQSLLNRW 426
            QE+ D L    E  + + Q        Q EE  ++ + +   +P   E  RK Q LL   
Sbjct: 850  QEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLL--- 906

Query: 427  REKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVE 486
                     Q + +EL+  +  K+ + +      +     QE+  L R  ++K    E E
Sbjct: 907  ---------QEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERE 957

Query: 487  RMGAKGLQLELSRAQ--------------EARRRWQQQTASAEEQLRLVVNAVSSSQIWL 532
            R   K  +L+    Q              E + R +++    EEQL          Q W 
Sbjct: 958  RQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWE 1017

Query: 533  ETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSL 592
                 K E     L     +L    R+   ++    +     +L+QE   L     +   
Sbjct: 1018 RQYRKKDE-----LQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERET-- 1070

Query: 593  ELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLA 652
              +Q  E + R + ELQ      Q+E    RE+ E  R+Q  +   + E+ELQQ +E L 
Sbjct: 1071 RRRQELERQYRKEEELQ------QEEEQLLREEPEKRRRQERERQCREEEELQQEEEQL- 1123

Query: 653  SLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRL 712
                 L   R+ ++    E     +E  QQ+E   Q L+E   E E R R++L    R  
Sbjct: 1124 -----LREEREKRRRQELERQYREEEEVQQEE--EQLLRE---EPEKRRRQELERQYREE 1173

Query: 713  NEARREHAKAVVSLRQIQRRAAQEKERS-QELRRLQEEARKE 753
             E ++E  +    LR+ Q +  QE+ER  +E   LQ + RK+
Sbjct: 1174 EELQQEEEQL---LREEQEKRRQERERQYREEEELQRQKRKQ 1212



 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 135/561 (24%), Positives = 235/561 (41%), Gaps = 87/561 (15%)

Query: 233 EGLRAALAGAE-VVRKNLEEGSQRELEEVQR-LHQEQLSSLTQAHEEALSSLTSKAEGLE 290
           E  RA   G E +++   +E  QR  E   R L +E      Q  +E    L    E  E
Sbjct: 97  EEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSE 156

Query: 291 KSLSSLETRRAGEAKELAEAQREAELLRKQLSKTQEDLE--AQVTLVENLRKYVGEQVPS 348
           K           E  E  + QR  E L +Q  + QE  E  A+   +++ + +  E+ P 
Sbjct: 157 KQ----------ERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPD 206

Query: 349 EVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPS 408
           E      +L R++LLE  +  +E++          Q RV         QEEE        
Sbjct: 207 EE-----QLRRRELLELRRKGREEKQQQRRER---QDRV--------FQEEE-------- 242

Query: 409 DSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQE 468
              E E+ RK +++L +  EK+     Q + +  E  + +++L+ Q   L+ +   + Q+
Sbjct: 243 ---EKEW-RKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQ--ELRRERQEEEQQ 296

Query: 469 QAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSS 528
           Q  L+R  Q +  + E  R      Q E  R Q+ RR  +QQ    E+QLR         
Sbjct: 297 QQRLRREQQLRRKQEEERRE-----QQEERREQQERR--EQQEERREQQLRREQEERREQ 349

Query: 529 QIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVT 588
           Q+  E    + E    +      R    +R+   +R          QLR+E         
Sbjct: 350 QLRREQEEERREQQLRREQE-EERREQQLRREQQLR-------REQQLRREQ-------- 393

Query: 589 DVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQ 648
            +  E Q  RE++ R + +L+   +L +++  + R + E ER +     ++ EQ L++ Q
Sbjct: 394 QLRREQQLRREQQLRREQQLRREQQLRREQ--QLRREQEEERHEQKHEQERREQRLKREQ 451

Query: 649 ESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDT 708
           E            R+   +  EE     QE  +QQ    Q  + +   ++    E+    
Sbjct: 452 EE-----------RRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQ 500

Query: 709 ERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERD 768
           ERR  + RRE  +     R+ + +  +E+ER Q+  R +++ R+E+ +   RR Q L+R+
Sbjct: 501 ERREQQLRREQEER----REQRLKRQEEEERLQQRLRSEQQLRREQEE---RREQLLKRE 553

Query: 769 KNLMLATLQQEGLLSRYKQQR 789
           +   L   ++E  L R +++R
Sbjct: 554 EEKRLEQERREQRLKREQEER 574



 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 145/664 (21%), Positives = 279/664 (42%), Gaps = 55/664 (8%)

Query: 151  ERDVSSDRQEPGRRGRSWGLEGSQALSQQAEVIVRQ--LQELRRLEEEVRLLRETSLQQK 208
            + D    R +  RR + W  +  +   ++   +  +  LQE  R E+++    E  LQ++
Sbjct: 857  QEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQRE 916

Query: 209  MRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLHQEQL 268
             R + +  E E   R E+  + E E L              EE  +R  +E +R +++  
Sbjct: 917  EREKRRRQEQERQYREEEQLQQEEEQLLR------------EEREKRRRQERERQYRKD- 963

Query: 269  SSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQREAELLRKQLSKTQ-ED 327
              L Q  E+ L     K    E+       ++  E +EL   Q E +LLR++  K + ++
Sbjct: 964  KKLQQKEEQLLGEEPEKRRRQERE------KKYREEEELQ--QEEEQLLREEREKRRRQE 1015

Query: 328  LEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRV 387
             E Q    + L++   EQ+  E   +    ER++     + LQ++ + L    E  + R 
Sbjct: 1016 WERQYRKKDELQQEE-EQLLREEREKRRLQERERQYREEEELQQEEEQL--LGEERETRR 1072

Query: 388  QSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDS 447
            +        +EEEL ++ +     EPE  R+ Q    + RE+     +Q + ++L   + 
Sbjct: 1073 RQELERQYRKEEELQQEEEQLLREEPEKRRR-QERERQCREEE---ELQQEEEQLLREER 1128

Query: 448  VKQLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLE------LSRAQ 501
             K+ + ++     +     QE+  L R   +K    E+ER   +  +L+      L   Q
Sbjct: 1129 EKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQ 1188

Query: 502  EARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVH 561
            E RR+ +++    EE+L+              + +        +    +N++    R+  
Sbjct: 1189 EKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENE 1248

Query: 562  TIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLR-EERNRLDAELQLSARLIQQEVG 620
              R L   +L   Q +Q+   L     +   E ++ R ++R+R   E +   R  Q+E  
Sbjct: 1249 QFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAK 1308

Query: 621  RAREQGEAERQQLSKVAQQLEQELQQT------QESLASLGLQLEVARQGQQESTEEAAS 674
            R R++   E +QL +  ++ ++  Q+T      +E L     +  + RQ +     E   
Sbjct: 1309 R-RDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEEL 1367

Query: 675  LRQE-----LTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQI 729
              QE     L ++Q L  Q  + K  + E +LR Q  + E++L + R    +        
Sbjct: 1368 RHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQ--EREQQLRQDRDRKFREEEQQLSR 1425

Query: 730  QRRAAQEKERSQELRRLQEEARK--EEGQRLARRLQELERDKNLMLATLQQEGLLSRYKQ 787
            Q R  + +E  Q++RR QE  RK  EE Q+L +      R++  +L   +++ L  + + 
Sbjct: 1426 QERDRKFREEEQQVRR-QERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERD 1484

Query: 788  QRLL 791
            ++ L
Sbjct: 1485 RKFL 1488



 Score = 76.6 bits (187), Expect = 9e-14
 Identities = 167/702 (23%), Positives = 286/702 (40%), Gaps = 104/702 (14%)

Query: 127  VQPPGHQDVSERRLDTQRPQVTMWERDVSSDRQEPGRRGRSWGLEGSQALSQQAEVIVRQ 186
            +Q    Q + E R   +R ++    R+    +QE  +  R    E  +   Q+ E   R+
Sbjct: 1116 LQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLRE---EPEKRRRQELERQYRE 1172

Query: 187  LQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGA---- 242
             +EL+  +EE +LLRE   +++   E Q  E E L R ++  R   E  R+ L       
Sbjct: 1173 EEELQ--QEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPE 1230

Query: 243  --EVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRR 300
                VR N      RE E+ ++L   QL    +  ++ L  L  + +  ++       ++
Sbjct: 1231 KENAVRDNKVYCKGRENEQFRQLEDSQLRD--RQSQQDLQHLLGEQQERDREQERRRWQQ 1288

Query: 301  AG---------EAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGE----QVP 347
                       E +E  EA+R     +++    +E+ E +    E  RK+  E    Q  
Sbjct: 1289 RDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQER 1348

Query: 348  SEVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELT---RK 404
             E   +  E +R+   E ++H ++ R  L    E  ++R Q        +E++L    R+
Sbjct: 1349 EEQPLRRQERDRKFREEELRHQEQGRKFLE---EEQRLRRQERERKFLKEEQQLRCQERE 1405

Query: 405  VQPSDSLEPEFTRKCQSLLNRWREKVFALMVQ-LKAQELEHSDSVKQLKGQVASLQEKVT 463
             Q     + +F  + Q L  + R++ F    Q ++ QE E     K L+ +    QE+  
Sbjct: 1406 QQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERER----KFLEEEQQLRQERHR 1461

Query: 464  SQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELS-RAQEARRRWQQQTASAEEQLRLVV 522
               +E+ +LQ   + +    E +R   K L+ E   R QE  R++++Q   ++E  R  +
Sbjct: 1462 KFREEEQLLQEREEQQLHRQERDR---KFLEEEQQLRRQERDRKFREQELRSQEPERKFL 1518

Query: 523  NAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCP 582
                  Q+  +    K      QL                 RG   R+    + R+E   
Sbjct: 1519 E--EEQQLHRQQRQRKFLQEEQQLRRQE-------------RGQQRRQDRDRKFREEE-- 1561

Query: 583  LPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQ 642
                      +L+Q REE+     E     RL +Q+V R     E ER+ +    Q   Q
Sbjct: 1562 ----------QLRQEREEQQLSRQERDRKFRLEEQKVRRQ----EQERKFMEDEQQLRRQ 1607

Query: 643  ELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLR 702
            E QQ               RQ +     E   L QE  ++Q+L+ Q    K  E E +LR
Sbjct: 1608 EGQQQ-------------LRQERDRKFREDEQLLQE-REEQQLHRQERDRKFLEEEPQLR 1653

Query: 703  EQLSDTERRLNEARR--------EHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARK-- 752
             Q  + + R +  R+        +  +     RQ + R  +E+E  Q+LRR QE  RK  
Sbjct: 1654 RQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEE--QQLRR-QERERKFL 1710

Query: 753  EEGQRLARRLQELE---RDKNLMLATLQQEGLLSRYKQQRLL 791
            +E Q+L R  QELE   R++  +    +QE L  + + +++L
Sbjct: 1711 QEEQQLRR--QELERKFREEEQLRQETEQEQLRRQERYRKIL 1750



 Score = 50.1 bits (118), Expect = 9e-06
 Identities = 56/204 (27%), Positives = 93/204 (45%), Gaps = 20/204 (9%)

Query: 594 LQQLREERNRLDAELQLSARLIQQEVGRAREQGEAERQ-QLSKVAQQLEQELQQTQESLA 652
           LQ  R+E ++   E +   R +++E G+ R Q   E++ +L++  +Q E++ +  Q    
Sbjct: 110 LQDRRQEEDQRRFEPR--DRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQ 167

Query: 653 SLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRL 712
               +L   RQ  QE  E     R E  Q Q   G   +E   E + R RE L    +  
Sbjct: 168 RRDEELWRQRQEWQEREER----RAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGR 223

Query: 713 NEARREHAKAVVSLRQIQRRAAQEKE------RSQELRRLQEEARKEEGQRLARRLQELE 766
            E +++        R+ Q R  QE+E      R   LR+ +E+ ++EE QR     +E E
Sbjct: 224 EEKQQQR-------RERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEE 276

Query: 767 RDKNLMLATLQQEGLLSRYKQQRL 790
           + + L    L++E      +QQRL
Sbjct: 277 QLRKLERQELRRERQEEEQQQQRL 300


>gi|16262452 cingulin [Homo sapiens]
          Length = 1203

 Score =  114 bits (284), Expect = 5e-25
 Identities = 162/691 (23%), Positives = 279/691 (40%), Gaps = 115/691 (16%)

Query: 202 ETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQRELEEVQ 261
           ETS+++K+ L  + M+   +          + G   A+AG   + + +EE  ++  EEV+
Sbjct: 330 ETSVRRKVSLVLEKMQPLVMV---------SSGSTKAVAGQGELTRKVEELQRKLDEEVK 380

Query: 262 RLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQREAELLRKQL 321
           +  +++L       E  L   T +   L++ L     RR GEA++  +  +  + L  Q 
Sbjct: 381 K--RQKLEPSQVGLERQLEEKTEECSRLQELLE----RRKGEAQQSNKELQNMKRLLDQG 434

Query: 322 SKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQHLQEDRDSLHATAE 381
              +  LE QV  ++N  K+V    P++      E+  + LLET + L+E  +      E
Sbjct: 435 EDLRHGLETQVMELQNKLKHVQGPEPAK------EVLLKDLLETRELLEEVLEGKQRVEE 488

Query: 382 LLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQE 441
            L++R + LT +    +EE                                  V  + QE
Sbjct: 489 QLRLRERELTALKGALKEE----------------------------------VASRDQE 514

Query: 442 LEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQ 501
           +EH    +Q +     L+  +   +Q+ A+L+   Q  +A V       +GLQ EL    
Sbjct: 515 VEHVR--QQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALV-------RGLQRELEETS 565

Query: 502 EARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVH 561
           E    WQ      +E LR      ++ Q  L+  M K E        L  ++    R++ 
Sbjct: 566 EETGHWQSMFQKNKEDLR------ATKQELLQLRMEKEE----MEEELGEKIEVLQRELE 615

Query: 562 TIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGR 621
             R        +  L++E       + ++  E Q         D EL+    +++ E  R
Sbjct: 616 QARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADR 675

Query: 622 AREQGEAERQQLSKVAQQLEQELQQTQ------ESLASLGLQLEVA-----RQGQQESTE 670
            RE  E +  QL K  QQL Q+ ++        E+ A++  Q   A     R+ Q+E+ E
Sbjct: 676 GREL-EEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDE 734

Query: 671 ---EAASLRQELTQQQELY--GQALQEKVAEVETRLREQLSDTERRLNEARREHAKAVVS 725
                  L Q+L + + L   G+A++ ++ +   RL  +    E  LN ++ E      +
Sbjct: 735 FRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAA 794

Query: 726 -------LRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLAT--- 775
                  L + QR  A+  +  Q L R  EE  K+  + L R   ELE  K L+  T   
Sbjct: 795 KRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQR-EVLRRGKAELEEQKRLLDRTVDR 853

Query: 776 ----LQQEGLLSRYKQQRLLTVLPSLLDK-KKSVVSSPRPPECSASAPVAAAVPTRESIK 830
               L++ G  S+   Q+L   L    +K ++ V  + R  +  AS          E   
Sbjct: 854 LNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWAS--------EAEKTS 905

Query: 831 GSLSVLLDDLQDLSEAISKEEAVCQGDNLDR 861
           G LS L D++Q L +A+   +A      LD+
Sbjct: 906 GGLSRLQDEIQRLRQALQASQAERDTARLDK 936



 Score =  103 bits (256), Expect = 9e-22
 Identities = 176/728 (24%), Positives = 307/728 (42%), Gaps = 139/728 (19%)

Query: 181  EVIVRQLQELRRLEEEVRLLRETSLQQKMRL-EAQAMELEALARAEKAGR---------- 229
            EV+++ L E R L EEV L  +  +++++RL E +   L+   + E A R          
Sbjct: 463  EVLLKDLLETRELLEEV-LEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQ 521

Query: 230  --AEAEGLRAALAGA-------EVVRKN---LEEGSQRELEEV-------QRLHQEQLSS 270
               + E LR ++  A       E  R+    L  G QRELEE        Q + Q+    
Sbjct: 522  YQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKED 581

Query: 271  LTQAHEEALSSLTSKAEGLEKSLSSLET--RRAGEAKELAEAQREAELLRKQLSKTQEDL 328
            L    +E L     K E  E+    +E   R   +A+  A   R+ E+L+K+L +TQE+L
Sbjct: 582  LRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEEL 641

Query: 329  EAQVTLVENLRKYVGEQVPSEVHSQT----------WELERQ--KLLETMQHLQEDRDSL 376
            + ++      ++  G     E+  Q            ELE Q  +L +T+Q L++D +  
Sbjct: 642  K-ELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEA 700

Query: 377  HATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKC----------------- 419
                 + +     L    A  E  L    + +D    EF R+                  
Sbjct: 701  SKAKMVAEAEATVLGQRRAAVETTLRETQEEND----EFRRRILGLEQQLKETRGLVDGG 756

Query: 420  QSLLNRWREKVFALMVQLKAQELEHSDSVKQ------------LKGQVASLQEKVTSQSQ 467
            +++  R R+K+  L  + + Q+LE + +  Q            L+ ++   Q  +    Q
Sbjct: 757  EAVEARLRDKLQRL--EAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQ 814

Query: 468  EQAILQRSLQDKAAEVEVERMGAKGLQ--------------LELSRAQEARRRWQQQTAS 513
            EQ  L R+L+++  + EV R G   L+               EL +  E  ++  QQ  +
Sbjct: 815  EQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQA 874

Query: 514  -----AEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRG--- 565
                  E+  R V +A   ++ W  +   K  G  ++L     RL  A++     R    
Sbjct: 875  QLEDYKEKARREVADAQRQAKDW-ASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTAR 933

Query: 566  ----LIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAEL---QLSARLIQQE 618
                L+A++  L  L QE+        D + +L+ L E+ +RL+ EL   + +  L+   
Sbjct: 934  LDKELLAQR--LQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDR 991

Query: 619  VGRAREQGEAERQQL--SKVAQQ--------LEQELQQTQESLASL-GLQLEVARQGQQE 667
            V R R+Q +  R +L   + A+Q        LE++ +  +  LAS  G Q   A   Q E
Sbjct: 992  VNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLE 1051

Query: 668  STEEAASLRQELTQQQELYGQALQEKVAEVETRLRE---QLSDTERRLNEARREHAKAVV 724
            S  +   L QE  Q +E     LQ    ++E +++E   Q+ D  + +N+ + + +  V 
Sbjct: 1052 SQNQ---LLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVK 1108

Query: 725  SLRQIQRRAAQEKERSQELRRLQE---EARKEEGQRLARRLQELERD------KNLMLAT 775
            +L++    A +E ER   LR+  +   E + E  ++L  R++ LE+D      ++   + 
Sbjct: 1109 ALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKDSWRKASRSAAESA 1168

Query: 776  LQQEGLLS 783
            L+ EGL S
Sbjct: 1169 LKNEGLSS 1176



 Score = 97.8 bits (242), Expect = 4e-20
 Identities = 165/738 (22%), Positives = 314/738 (42%), Gaps = 134/738 (18%)

Query: 137  ERRLDTQ-------RPQVTMWERDVSSDRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQE 189
            +R+LD +        P     ER +    +E  R      LE  +  +QQ+    ++LQ 
Sbjct: 372  QRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQEL--LERRKGEAQQSN---KELQN 426

Query: 190  LRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRKNL 249
            ++RL ++   LR         LE Q MEL+   +  +      E L   L     + + +
Sbjct: 427  MKRLLDQGEDLRHG-------LETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEV 479

Query: 250  EEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAE 309
             EG QR +EE  RL + +L++L  A +E ++S   + E + +                 +
Sbjct: 480  LEGKQR-VEEQLRLRERELTALKGALKEEVASRDQEVEHVRQ-----------------Q 521

Query: 310  AQREAELLRKQLSKTQED---LEAQ----VTLVENLRKYVGEQVPSEVHSQTW------- 355
             QR+ E LR+ +    +D   LEA+      LV  L++ + E      H Q+        
Sbjct: 522  YQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKED 581

Query: 356  -ELERQKLLETMQHLQEDRDSLHATAELLQVRVQSL------THILALQEEELTRKVQPS 408
                +Q+LL+     +E  + L    E+LQ  ++        T  + + ++EL R  +  
Sbjct: 582  LRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEEL 641

Query: 409  DSLEPEFTRKCQSLLNRWR----EKVFALMV-------QLKAQELEHSDSVKQLKGQVAS 457
              L+ E  R+ Q +  R R    EK  A++        +L+ Q L+   +++QL+     
Sbjct: 642  KELQAE--RQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEE 699

Query: 458  LQE-------KVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSR---------AQ 501
              +       + T   Q +A ++ +L++   E +  R    GL+ +L           A 
Sbjct: 700  ASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAV 759

Query: 502  EARRRWQQQTASAE-EQLRLVVNA-------VSSSQIWLETTMAKVEGAAAQLPSLNNRL 553
            EAR R + Q   AE +QL   +NA       +++++  LE  + + +   A+L      L
Sbjct: 760  EARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTL 819

Query: 554  SYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNR----LDAELQ 609
            + A+ +    R ++ R    A+L ++   L   V  ++ EL+++ E+  +    L A+L+
Sbjct: 820  NRALEEEGKQREVLRR--GKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLE 877

Query: 610  LSARLIQQEVGRAREQGE---AERQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQ 666
                  ++EV  A+ Q +   +E ++ S    +L+ E+Q+ +++L +   + + AR  ++
Sbjct: 878  DYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKE 937

Query: 667  ESTEEAASLRQELTQQQELYG------QALQEKVAEVETRLREQLSDTER---RLNEARR 717
               +    L QE   ++          + L+EKV+ +ET L E+ +  E    R+N  R 
Sbjct: 938  LLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRD 997

Query: 718  EHAKAVVSLRQIQRRAAQEKERSQ-ELRRLQEEAR-------------------KEEGQR 757
            +  +    L Q +R A Q+ E  +  L R  ++ +                   + + Q 
Sbjct: 998  QVDQLRTELMQ-ERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQL 1056

Query: 758  LARRLQELERDKNLMLAT 775
            L  RLQ  ER+K ++ +T
Sbjct: 1057 LQERLQAEEREKTVLQST 1074


>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
            sapiens]
          Length = 1939

 Score =  109 bits (273), Expect = 1e-23
 Identities = 155/743 (20%), Positives = 319/743 (42%), Gaps = 85/743 (11%)

Query: 137  ERRLDTQRPQVTMWERDVSSDRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQ-ELRRLEE 195
            E  +DT+  +  + E+    + +    +G+   +E  QAL+ Q +  +++LQ  +  LEE
Sbjct: 1068 ESTMDTENDKQQLNEKLKKKEFEMSNLQGK---IEDEQALAIQLQKKIKELQARIEELEE 1124

Query: 196  EVRLLRETSLQQKMRLEAQAMELEALA-RAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQ 254
            E+   R +  + + +    + ELE ++ R E+AG A +       A  E+ +K   E  +
Sbjct: 1125 EIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATS-------AQIEMNKKREAEFQK 1177

Query: 255  --RELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQR 312
              R+LEE    H+   ++L + H ++++ L  + + L++    LE  ++    E+ +   
Sbjct: 1178 MRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLAS 1237

Query: 313  EAELLRK------QLSKTQEDLEAQVTLVENLRKYVGEQVPSE---VHSQTWELERQ--- 360
              E + K      ++ +T ED  +++   E  ++ +  ++ ++   +H+++ E  RQ   
Sbjct: 1238 NMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDE 1297

Query: 361  -----------------KLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTR 403
                             ++ E  + L+E+  +    A  LQ    S  H   L  E+   
Sbjct: 1298 KDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQ----SARHDCDLLREQYEE 1353

Query: 404  KVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVT 463
            + +    L+   + K  S + +WR K     +Q + +ELE  ++ K+L  ++   +E V 
Sbjct: 1354 EQEAKAELQRGMS-KANSEVAQWRTKYETDAIQ-RTEELE--EAKKKLAQRLQDAEEHVE 1409

Query: 464  SQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVN 523
            + + + A L+++ Q    EVE        L +++ R+  A     ++  + ++ L     
Sbjct: 1410 AVNSKCASLEKTKQRLQNEVE-------DLMIDVERSNAACIALDKKQRNFDKVLAEWKQ 1462

Query: 524  AVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPL 583
                +Q  LE +  +    + +L  + N    ++  + T+      K     L+QE   L
Sbjct: 1463 KYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETL------KRENKNLQQEISDL 1516

Query: 584  PPPVTDVSLELQQLREERNRLDAEL-QLSARLIQQEVGRAREQGEAERQQL--SKVAQQL 640
               + +    + +L + + +LD E  +L   L + E     E+G+  R QL  ++V  ++
Sbjct: 1517 TEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEI 1576

Query: 641  EQELQQTQESLASLGLQ-LEVARQGQQESTEEAASLRQELTQQQELYGQALQEKV----- 694
            ++++ +  E L  L    L V    Q     E  S    L  ++++ G   + ++     
Sbjct: 1577 DRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHA 1636

Query: 695  ----AEVETRLREQ---LSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQ 747
                AE    LR     L DT+  L++A R        L  ++RRA   +   +ELR   
Sbjct: 1637 NRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASL 1696

Query: 748  EEARKEEGQRLARRLQELERDKNLMLATLQQEGLLSRYKQQRLLTVLPSLLDKKKSVVSS 807
            E  R E G+++A + + L+  + + L   Q   L++  K  +L T +  +  + + +V  
Sbjct: 1697 E--RTERGRKMAEQ-ELLDASERVQLLHTQNTSLINTKK--KLETDISQIQGEMEDIVQE 1751

Query: 808  PRPPECSASAPVAAAVPTRESIK 830
             R  E  A   +  A    E +K
Sbjct: 1752 ARNAEEKAKKAITDAAMMAEELK 1774



 Score = 87.0 bits (214), Expect = 7e-17
 Identities = 122/613 (19%), Positives = 264/613 (43%), Gaps = 73/613 (11%)

Query: 171  EGSQALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRA 230
            E ++    + E+      + R+LE+E   L++     ++ L     E  A     K    
Sbjct: 925  EVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTE 984

Query: 231  EAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAH---EEALSSLTSKAE 287
            E  GL   +A     +K L+E  Q+ L+++Q + ++++++LT+A    E+ +  L    E
Sbjct: 985  EMAGLDETIAKLTKEKKALQEAHQQTLDDLQ-MEEDKVNTLTKAKTKLEQQVDDLEGSLE 1043

Query: 288  GLEKSLSSLETRR---AGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGE 344
              +K    LE  +    G+ K   E+  + E  ++QL+   E L+ +   + NL+  + +
Sbjct: 1044 QEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLN---EKLKKKEFEMSNLQGKIED 1100

Query: 345  QVPSEVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRK 404
            +       Q   ++ QK ++ +Q   E+ +         + + +     L+ + EE++ +
Sbjct: 1101 E-------QALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISER 1153

Query: 405  VQP---SDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQ----ELEHSDSVKQLKGQVAS 457
            ++    + S + E  +K ++   + R  +    +Q +A       +H+DSV +L  Q+ S
Sbjct: 1154 LEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDS 1213

Query: 458  LQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQ 517
            LQ       +E++ L+  + D A+ +E                 +A+  +++   + E+Q
Sbjct: 1214 LQRVKQKLEKEKSELKMEINDLASNMET--------------VSKAKANFEKMCRTLEDQ 1259

Query: 518  LRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKL-----A 572
            L                  ++++    +   L N LS    ++HT  G  +R+L      
Sbjct: 1260 L------------------SEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAM 1301

Query: 573  LAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQ 632
            ++QL +        + ++  +L++  + ++ L   LQ SAR    +    REQ E E++ 
Sbjct: 1302 VSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQ-SAR---HDCDLLREQYEEEQE- 1356

Query: 633  LSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQE 692
                  +L++ + +    +A    + E     + E  EEA     +  Q  E + +A+  
Sbjct: 1357 ---AKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNS 1413

Query: 693  KVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQR---RAAQEKERSQELRRLQEE 749
            K A +E   +   ++ E  + +  R +A A ++L + QR   +   E ++  E  + + E
Sbjct: 1414 KCASLEKTKQRLQNEVEDLMIDVERSNA-ACIALDKKQRNFDKVLAEWKQKYEETQAELE 1472

Query: 750  ARKEEGQRLARRL 762
            A ++E + L+  L
Sbjct: 1473 ASQKESRSLSTEL 1485



 Score = 77.4 bits (189), Expect = 5e-14
 Identities = 126/637 (19%), Positives = 259/637 (40%), Gaps = 94/637 (14%)

Query: 187  LQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVR 246
            L +L+  E++V  L +     K +LE Q  +LE     EK    + E  +  L G   + 
Sbjct: 1011 LDDLQMEEDKVNTLTKA----KTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLA 1066

Query: 247  KNLE---EGSQRELEEVQRLHQEQLSSLTQAHEEA----------LSSLTSKAEGLEKSL 293
            +      E  +++L E  +  + ++S+L    E+           +  L ++ E LE+ +
Sbjct: 1067 QESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEI 1126

Query: 294  SSLETRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTL-------VENLRKYVGEQV 346
             +    RA   K+ ++  RE E + ++L +      AQ+ +        + +R+ + E  
Sbjct: 1127 EAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEST 1186

Query: 347  PSEVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQ 406
                H  T    R+K  +++  L E  DSL    + L+     L     ++  +L   ++
Sbjct: 1187 LQ--HEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELK----MEINDLASNME 1240

Query: 407  PSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQS 466
                 +  F + C++L ++  E        +K +E E    + +L  Q A L        
Sbjct: 1241 TVSKAKANFEKMCRTLEDQLSE--------IKTKEEEQQRLINELSAQKARLHT------ 1286

Query: 467  QEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAE----------- 515
             E     R L +K A V      ++G Q    + +E +R+ +++T +             
Sbjct: 1287 -ESGEFSRQLDEKDAMVS---QLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARH 1342

Query: 516  --EQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLAL 573
              + LR        ++  L+  M+K     AQ      R  Y    +     L   K  L
Sbjct: 1343 DCDLLREQYEEEQEAKAELQRGMSKANSEVAQW-----RTKYETDAIQRTEELEEAKKKL 1397

Query: 574  AQLRQESCPLPPPVTDVSLELQQLRE------ERNRLDAELQLSARLIQQEVGRAREQGE 627
            AQ  Q++      V      L++ ++      E   +D E   +A +   +  R  ++  
Sbjct: 1398 AQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVL 1457

Query: 628  AERQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYG 687
            AE +Q     ++ + EL+ +Q+   SL  +L   +   +ES +   +L++E         
Sbjct: 1458 AEWKQKY---EETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRE--------N 1506

Query: 688  QALQEKVAEVETRLREQLSDTERRLNEARR-----EHAKAVVSLRQIQRRAAQEKERSQE 742
            + LQ+++++    L EQ+++  + ++E  +     +H K+ +     +  A+ E E  + 
Sbjct: 1507 KNLQQEISD----LTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKI 1562

Query: 743  LRRLQE--EARKEEGQRLARRLQELERDKNLMLATLQ 777
            LR   E  + + E  +++A + +EL++ K   L  ++
Sbjct: 1563 LRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVE 1599



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 125/622 (20%), Positives = 263/622 (42%), Gaps = 117/622 (18%)

Query: 299  RRAGEAKELAEAQREAELLRKQLSKTQ----EDLEAQVTLVENLRKYVGEQVPSEVHSQT 354
            + A   KE+A  + E E  +++L+KT+    E  E  VTL++                  
Sbjct: 845  KSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQ--------------EKND 890

Query: 355  WELERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPE 414
             +L+ Q   + +   +E  D L  T   L+ ++           +E+T + +  + +  E
Sbjct: 891  LQLQVQAEADALADAEERCDQLIKTKIQLEAKI-----------KEVTERAEDEEEINAE 939

Query: 415  FT---RKCQSLLNRWREKVFALMVQL-KAQELEHS--DSVKQLKGQVASLQEKVTSQSQE 468
             T   RK +   +  ++ +  L + L K ++ +H+  + VK L  ++A L E +   ++E
Sbjct: 940  LTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKE 999

Query: 469  QAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQT----ASAEEQLRLVVNA 524
            +  LQ + Q    ++++E       + +++   +A+ + +QQ      S E++ +L ++ 
Sbjct: 1000 KKALQEAHQQTLDDLQME-------EDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMD- 1051

Query: 525  VSSSQIWLETTMAKVEG-----------AAAQLPSLNNRLSYAVRKVHTIRGLIARKLAL 573
                   LE    K+EG                  LN +L     ++  ++G I  + AL
Sbjct: 1052 -------LERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQAL 1104

Query: 574  A-QLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQ 632
            A QL+++   L   + ++  E++  R  R + + +    +R +++   R  E G A   Q
Sbjct: 1105 AIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQ 1164

Query: 633  L----------SKVAQQLEQELQQTQ-----------ESLASLGLQLEVARQGQQESTEE 671
            +           K+ + LE+   Q +           +S+A LG Q++  ++ +Q+  +E
Sbjct: 1165 IEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKE 1224

Query: 672  AASLRQE---LTQQQELYGQA----------LQEKVAEVETRLREQLSDTERRLNEARRE 718
             + L+ E   L    E   +A          L+++++E++T+  EQ    +R +NE   +
Sbjct: 1225 KSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQ----QRLINELSAQ 1280

Query: 719  HAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQ 778
             A+      +  R+  ++     +L R  ++A  ++ + L R+L+E  + K+ +   LQ 
Sbjct: 1281 KARLHTESGEFSRQLDEKDAMVSQLSR-GKQAFTQQIEELKRQLEEETKAKSTLAHALQS 1339

Query: 779  -----EGLLSRY-KQQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGS 832
                 + L  +Y ++Q     L   + K  S V+  R      +     A+   E ++ +
Sbjct: 1340 ARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWR------TKYETDAIQRTEELEEA 1393

Query: 833  LSVLLDDLQDLSEAISKEEAVC 854
               L   LQD  E +    + C
Sbjct: 1394 KKKLAQRLQDAEEHVEAVNSKC 1415



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 113/571 (19%), Positives = 222/571 (38%), Gaps = 111/571 (19%)

Query: 189  ELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRKN 248
            EL   ++E R L     + K   E     LE L R  K  + E   L   +A        
Sbjct: 1470 ELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIA-------- 1521

Query: 249  LEEGSQR--ELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKE 306
              EG +   ELE+V++    + S L  + EEA +SL  +   + +    L   ++   ++
Sbjct: 1522 --EGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRK 1579

Query: 307  LAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETM 366
            +AE   E + L++   +  E +++               + +E+ S+   L  +K +E  
Sbjct: 1580 IAEKDEELDQLKRNHLRVVESMQS--------------TLDAEIRSRNDALRIKKKME-- 1623

Query: 367  QHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRW 426
                          +L ++ +Q L H    Q  E  R ++ +  +               
Sbjct: 1624 -------------GDLNEMEIQ-LNH-ANRQAAEALRNLRNTQGI--------------- 1653

Query: 427  REKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVE 486
                      LK  +L   D++   +GQ            ++ A+++R      AEVE  
Sbjct: 1654 ----------LKDTQLHLDDAI---RGQ--------DDLKEQLAMVERRANLMQAEVE-- 1690

Query: 487  RMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLV---VNAVSSSQIWLETTMAKVEGAA 543
                  L+  L R +  R+  +Q+   A E+++L+     ++ +++  LET +++++G  
Sbjct: 1691 -----ELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEM 1745

Query: 544  AQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNR 603
              +           +K  T   ++A +L   Q             D S  L+++++   +
Sbjct: 1746 EDIVQEARNAEEKAKKAITDAAMMAEELKKEQ-------------DTSAHLERMKKNMEQ 1792

Query: 604  LDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEVARQ 663
               +LQL  RL + E   A + G+ + Q+L    ++LE E++  Q+        L    +
Sbjct: 1793 TVKDLQL--RLDEAE-QLALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHER 1849

Query: 664  GQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARR-----E 718
              +E T +    R+ + + Q+L  + LQ KV   + +  E    +   L + R+     E
Sbjct: 1850 RVKELTYQTEEDRKNILRLQDLVDK-LQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELE 1908

Query: 719  HAKAVVSLRQIQRRAAQEKERSQELRRLQEE 749
             AK    + + Q    + K R    + + EE
Sbjct: 1909 EAKERADIAESQVNKLRVKSREVHTKVISEE 1939



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 84/378 (22%), Positives = 151/378 (39%), Gaps = 89/378 (23%)

Query: 188  QELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAG---RAEAEGLRAALAGAEV 244
            + LR L     +L++T L     +  Q    E LA  E+     +AE E LRA+L   E 
Sbjct: 1642 EALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLERTER 1701

Query: 245  VRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEA 304
             RK  E+      E VQ LH +             +SL +  + LE  +S ++    GE 
Sbjct: 1702 GRKMAEQELLDASERVQLLHTQN------------TSLINTKKKLETDISQIQ----GEM 1745

Query: 305  KELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLE 364
            +++ +  R AE       K ++ +     + E L+K   EQ                  +
Sbjct: 1746 EDIVQEARNAE------EKAKKAITDAAMMAEELKK---EQ------------------D 1778

Query: 365  TMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLN 424
            T  HL+  + ++  T + LQ+R+         + E+L  K            ++ Q L  
Sbjct: 1779 TSAHLERMKKNMEQTVKDLQLRLD--------EAEQLALK---------GGKKQIQKLEA 1821

Query: 425  RWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVE 484
            R RE    L  ++++++  + ++VK L+                    +R +++   + E
Sbjct: 1822 RVRE----LESEVESEQKHNVEAVKGLRKH------------------ERRVKELTYQTE 1859

Query: 485  VERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAA 544
             +R     LQ  + + Q   + +++Q   AEEQ  + +      Q  LE    + + A +
Sbjct: 1860 EDRKNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELEEAKERADIAES 1919

Query: 545  QLPSLNNRLSYAVRKVHT 562
            Q+    N+L    R+VHT
Sbjct: 1920 QV----NKLRVKSREVHT 1933


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score =  109 bits (272), Expect = 1e-23
 Identities = 171/742 (23%), Positives = 314/742 (42%), Gaps = 105/742 (14%)

Query: 183  IVRQLQELRRLEEEVRLLRETSLQQKMRLE----------AQAMELEALARAEKAGRAEA 232
            + RQ +E+   EEE+  +RE  L  + RL           A+ ++L+   +AE    AEA
Sbjct: 840  VSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEA 899

Query: 233  EGLRAALAG----AEVVRKNLEEGSQRELEEVQRLHQE---------QLSSLTQAHEEAL 279
            E LRA L       E +  +LE   + E E  Q L  E         +L    +  E A 
Sbjct: 900  EELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESAR 959

Query: 280  SSLTSKAEGLEKSLSSLETRRAGEAKELAEAQREAELLRKQLSK----TQEDLEAQVTLV 335
              L  +    E  L  LE  +     +  +  +E +LL  ++++      E+ E   +L 
Sbjct: 960  QKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLA 1019

Query: 336  ENLRKYVGEQVPSEVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILA 395
            +   K+       E   +  E +RQ+L +T + L+ D   L      LQ ++  L   LA
Sbjct: 1020 KLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLA 1079

Query: 396  LQEEELTRKVQPSDSLEPEFTRKCQSL--LNRWREKVFALMVQLKAQELEHSDSVKQLK- 452
             +EEEL   +     +E E  +K  +L  +     ++  L   L+++    + + KQ + 
Sbjct: 1080 KKEEELQAALA---RVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRD 1136

Query: 453  ----------------GQVASLQEKVTSQSQEQAILQRSLQDKAA--EVEVERMGAK--- 491
                               A+ QE  + + QE  IL+++L+++A   E +++ M  K   
Sbjct: 1137 LGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQ 1196

Query: 492  -----GLQLELSRAQEARRRWQQQTASAEE-QLRLVVNAVSSSQIWLETTMAKVEGAAAQ 545
                   QLE ++  +A     +QT   E  +L   V  +   +   E    KVE   AQ
Sbjct: 1197 AVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVE---AQ 1253

Query: 546  LPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLD 605
            L  L  + +   R    +R  +A K+   Q+  ++  +   ++    +  +L ++ + L+
Sbjct: 1254 LQELQVKFNEGER----VRTELADKVTKLQVELDN--VTGLLSQSDSKSSKLTKDFSALE 1307

Query: 606  AELQLSARLIQQE------VGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLE 659
            ++LQ +  L+Q+E      +    +Q E E+    +  ++ E+     ++ +A+L  Q+ 
Sbjct: 1308 SQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVA 1367

Query: 660  VARQGQQEST---EEAASLRQELTQQQELYGQALQEKVA------EVETRLREQLSDTER 710
              ++  ++S    E A  ++++L +  E   Q  +EKVA      + +TRL+++L D   
Sbjct: 1368 DMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLV 1427

Query: 711  RLNEARREHAKAVVSLRQIQRRAAQEK----ERSQELRRLQEEARKEEGQ--RLARRLQE 764
             L+  R+         ++  +  A+EK    + ++E  R + EAR++E +   LAR L+E
Sbjct: 1428 DLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEE 1487

Query: 765  LERDKNLMLATLQQEGLLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVP 824
                       ++Q+  L R  +Q   T +  L+  K  V  S    E S  A       
Sbjct: 1488 ----------AMEQKAELERLNKQ-FRTEMEDLMSSKDDVGKSVHELEKSKRALEQQV-- 1534

Query: 825  TRESIKGSLSVLLDDLQDLSEA 846
              E +K  L  L D+LQ   +A
Sbjct: 1535 --EEMKTQLEELEDELQATEDA 1554



 Score =  104 bits (259), Expect = 4e-22
 Identities = 165/809 (20%), Positives = 337/809 (41%), Gaps = 105/809 (12%)

Query: 138  RRLDTQRPQVTMWERDVSSDRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQELRRLEEEV 197
            RR + QR ++    R +  D  +   +      + ++   Q A+        L R+EEE 
Sbjct: 1037 RREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEA 1096

Query: 198  RLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGA-EVVRKNLEEG---- 252
               +  +L++   LE+Q  EL+    +E+A R +AE  +  L    E ++  LE+     
Sbjct: 1097 AQ-KNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDST 1155

Query: 253  -------SQRE---------LEEVQRLHQEQLSSLTQAHEEALSSLTSKAE-------GL 289
                   S+RE         LEE  + H+ Q+  + Q H +A+  L  + E        L
Sbjct: 1156 AAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANL 1215

Query: 290  EKSLSSLETRR---AGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQV 346
            EK+  +LE  R   A E K L + + ++E  RK++    ++L+ +    E +R  + ++V
Sbjct: 1216 EKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKV 1275

Query: 347  P-------------SEVHSQTWELERQ------KLLETMQHLQED-RDSLHATAELLQVR 386
                          S+  S++ +L +       +L +T + LQE+ R  L  + +L QV 
Sbjct: 1276 TKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVE 1335

Query: 387  VQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSD 446
             +  +    L+EEE     +   +LE +       + +  ++   ++     A+E++   
Sbjct: 1336 DEKNSFREQLEEEE-----EAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKL 1390

Query: 447  SVKQLKGQVASLQEKVTSQSQEQAI---LQRSLQDKAAEVEVERMGAKGLQLELSRAQEA 503
              K L+G     +EKV +  + +     LQ+ L D   +++ +R  A  L+ +  +  + 
Sbjct: 1391 Q-KDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQL 1449

Query: 504  RRRWQQQTAS-AEEQLRLVVNAVSSSQIWLETTMAKVEGAA--AQLPSLNNRLSYAVRKV 560
                +  +A  AEE+ R    A       L    A  E     A+L  LN +    +  +
Sbjct: 1450 LAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDL 1509

Query: 561  HTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREE-------RNRLDAELQLSAR 613
             + +  + +  ++ +L +    L   V ++  +L++L +E       + RL+  LQ    
Sbjct: 1510 MSSKDDVGK--SVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKA 1567

Query: 614  LIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQE--------------SLASLGLQLE 659
              ++++    EQ E +++QL +  +++E EL+  ++               L  L   ++
Sbjct: 1568 QFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHID 1627

Query: 660  VARQGQQESTEEAASLRQEL-----------TQQQELYGQAL--QEKVAEVET---RLRE 703
             A + + E+ ++   L+ ++             ++E+  QA   ++K+  +E    +L+E
Sbjct: 1628 SANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQE 1687

Query: 704  QLSDTERRLNEARREHAKAVVSLRQIQRRA--AQEKERSQELRRLQEEARKEEGQRLARR 761
            +L+  ER   +A++E  +    +     +   A E++R  E R  Q E   EE Q     
Sbjct: 1688 ELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTEL 1747

Query: 762  LQELERDKNLMLATLQQEGLLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAA 821
            + +  +  NL +  +  +  L R   Q+       L  + K +    +  E +  +   A
Sbjct: 1748 INDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKA 1807

Query: 822  AVPTRESIKGSLSVLLDDLQDLSEAISKE 850
            ++   E+    L   LD+     +A  K+
Sbjct: 1808 SITALEAKIAQLEEQLDNETKERQAACKQ 1836



 Score = 93.2 bits (230), Expect = 9e-19
 Identities = 140/626 (22%), Positives = 257/626 (41%), Gaps = 52/626 (8%)

Query: 173  SQALSQQAEVIVRQLQELRRL-EEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAE 231
            S  L++    +  QLQ+ + L +EE R     S + K   + +    E L   E+A    
Sbjct: 1296 SSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNL 1355

Query: 232  AEGLRAALAGAEVVRKNLEE--GSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGL 289
             + +    A    ++K +E+  G     EEV+R  Q+ L  L+Q HEE +++     + L
Sbjct: 1356 EKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAY----DKL 1411

Query: 290  EKSLSSLETRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSE 349
            EK+ + L+        +L   ++ A  L K+  K  + L  + T+     KY  E+  +E
Sbjct: 1412 EKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISA---KYAEERDRAE 1468

Query: 350  VHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQSL----------THILALQEE 399
              ++  E +   L   ++   E +  L    +  +  ++ L           H L   + 
Sbjct: 1469 AEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKR 1528

Query: 400  ELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQ 459
             L ++V+   +   E   + Q+      +    L V L+A + +     + L+G+    +
Sbjct: 1529 ALEQQVEEMKTQLEELEDELQAT----EDAKLRLEVNLQAMKAQFE---RDLQGRDEQSE 1581

Query: 460  EKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLR 519
            EK     ++   ++  L+D+  +  +     K L+++L   +       +    A +QLR
Sbjct: 1582 EKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLR 1641

Query: 520  LVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRL-SYAVRKVHTIRGLIARKLALAQLRQ 578
             +   +      L+ T A  E   AQ      +L S     +     L A + A  Q +Q
Sbjct: 1642 KLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQ 1701

Query: 579  ESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAE--RQQLSKV 636
            E   L   + + S +     EE+ RL+A      R+ Q E     EQG  E    +L K 
Sbjct: 1702 ERDELADEIANSSGKGALALEEKRRLEA------RIAQLEEELEEEQGNTELINDRLKKA 1755

Query: 637  AQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELT----QQQELYGQALQE 692
              Q++Q +        S   + E ARQ  +   +E     QE+      + +    AL+ 
Sbjct: 1756 NLQIDQ-INTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEA 1814

Query: 693  KVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQI---QRRAAQEKE-------RSQE 742
            K+A++E +L  +  + +    + RR   K    L Q+   +R A Q K+       R ++
Sbjct: 1815 KIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQ 1874

Query: 743  LRRLQEEARKEEGQRLARRLQELERD 768
            L+R  EEA +EE QR     ++L+R+
Sbjct: 1875 LKRQLEEA-EEEAQRANASRRKLQRE 1899



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 104/486 (21%), Positives = 209/486 (43%), Gaps = 46/486 (9%)

Query: 316  LLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQHLQEDRDS 375
            L RK  +K Q+ L A   L  N   Y+      ++ +  W     K+   +Q  +++ + 
Sbjct: 794  LARKAFAKRQQQLTAMKVLQRNCAAYL------KLRNWQWWRLFTKVKPLLQVSRQEEEM 847

Query: 376  LHATAELLQVRVQSL------THILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREK 429
            +    EL++VR + L      T +  LQ + +  K+Q  + L+ E T  C         +
Sbjct: 848  MAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAE-TELCA--------E 898

Query: 430  VFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMG 489
               L  +L A++ E  +    L+ +V   +E+      E+  +Q+++Q+   ++E E   
Sbjct: 899  AEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESA 958

Query: 490  AKGLQLE-------LSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGA 542
             + LQLE       L + +E +   + Q     ++ +L+ + ++       T + + E  
Sbjct: 959  RQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAE----FTTNLTEEEEK 1014

Query: 543  AAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERN 602
            +  L  L N+    +  +     L   +    +L +    L    TD+S ++ +L+ +  
Sbjct: 1015 SKSLAKLKNKHEAMITDLE--ERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIA 1072

Query: 603  RLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEVAR 662
             L  +L      +Q  + R  E+   +   L K+ ++LE ++ + QE L S       A 
Sbjct: 1073 ELKMQLAKKEEELQAALARVEEEAAQKNMALKKI-RELESQISELQEDLESERASRNKAE 1131

Query: 663  QGQQESTEEAASLRQEL-------TQQQELYGQALQEKVAEVETRLREQLSDTERRLNEA 715
            + +++  EE  +L+ EL         QQEL  +  QE V  ++  L E+    E ++ E 
Sbjct: 1132 KQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQE-VNILKKTLEEEAKTHEAQIQEM 1190

Query: 716  RREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQ---ELERDKNLM 772
            R++H++AV  L +   +  + K   ++ ++  E  R E    +   LQ   + E  +  +
Sbjct: 1191 RQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKV 1250

Query: 773  LATLQQ 778
             A LQ+
Sbjct: 1251 EAQLQE 1256



 Score = 73.6 bits (179), Expect = 8e-13
 Identities = 94/457 (20%), Positives = 201/457 (43%), Gaps = 57/457 (12%)

Query: 133  QDVSERRLDTQR--PQVTMWERDVSSDRQEPGRRGRSWGLEGSQ-ALSQQAEVIVRQLQE 189
            ++  E++ + +R   Q      D+ S + + G+      LE S+ AL QQ E +  QL+E
Sbjct: 1486 EEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHE--LEKSKRALEQQVEEMKTQLEE 1543

Query: 190  LRRLEEEVRLLRETSLQQKMRLEAQAMELEA---------------LARAEKAGRAEAEG 234
            L   E+E++   +  L+ ++ L+A   + E                L R  +   AE E 
Sbjct: 1544 L---EDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELED 1600

Query: 235  LRAALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLS 294
             R   + A   RK LE     +L++++      + S  +  +EA+  L      ++  + 
Sbjct: 1601 ERKQRSMAVAARKKLE----MDLKDLEA----HIDSANKNRDEAIKQLRKLQAQMKDCMR 1652

Query: 295  SLETRRAGEAKELAEAQREAELLRK---QLSKTQEDLEAQVTL---VENLRKYVGEQVPS 348
             L+  RA   + LA+A+   + L+    ++ + QE+L A        +  R  + +++ +
Sbjct: 1653 ELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIAN 1712

Query: 349  EVHSQTWELERQKLLET-MQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQP 407
                    LE ++ LE  +  L+E+ +      EL+  R++       LQ +++   +  
Sbjct: 1713 SSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKAN----LQIDQINTDL-- 1766

Query: 408  SDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQE----LEHSDSVKQLKGQVASLQEKVT 463
              +LE    +K ++   +   +   L V+L+  E     ++  S+  L+ ++A L+E++ 
Sbjct: 1767 --NLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLD 1824

Query: 464  SQSQEQAIL-------QRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEE 516
            ++++E+          ++ L+D   +V+ ER  A+  + +  +A    ++ ++Q   AEE
Sbjct: 1825 NETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEE 1884

Query: 517  QLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRL 553
            + +    +    Q  LE      +    ++ SL N+L
Sbjct: 1885 EAQRANASRRKLQRELEDATETADAMNREVSSLKNKL 1921



 Score = 54.3 bits (129), Expect = 5e-07
 Identities = 77/359 (21%), Positives = 152/359 (42%), Gaps = 37/359 (10%)

Query: 170  LEGSQALSQQAEV-IVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAG 228
            L+G    S++ +  +VRQ++E+    E+ R  R  ++  + +LE    +LEA   +    
Sbjct: 1573 LQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKN 1632

Query: 229  RAEA-EGLRAALAGAEVVRKNLEE--GSQRELEEVQRLHQEQLSSLT----QAHEEALSS 281
            R EA + LR   A  +   + L++   S+ E+    + ++++L S+     Q  EE  ++
Sbjct: 1633 RDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAA 1692

Query: 282  LTSKAEGLEK--SLSSLETRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLR 339
              +K +  ++   L+      +G+     E +R  E    QL +  E+ +    L+ +  
Sbjct: 1693 ERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRL 1752

Query: 340  KYVGEQVPS--------EVHSQTWELERQKLLETMQHLQEDRDSLHATAEL-LQVRVQSL 390
            K    Q+            H+Q  E  RQ+L    + L+     +  T +   +  + +L
Sbjct: 1753 KKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITAL 1812

Query: 391  THILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQL----------KAQ 440
               +A  EE+L       D+   E    C+ +  R  +K+  +++Q+          K Q
Sbjct: 1813 EAKIAQLEEQL-------DNETKERQAACKQV-RRTEKKLKDVLLQVDDERRNAEQYKDQ 1864

Query: 441  ELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSR 499
              + S  +KQLK Q+   +E+    +  +  LQR L+D     +        L+ +L R
Sbjct: 1865 ADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRR 1923



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 58/244 (23%), Positives = 105/244 (43%), Gaps = 22/244 (9%)

Query: 618  EVGRAREQGEAERQQLSKV------AQQLEQELQQTQESLASLGLQLEVARQGQQESTEE 671
            +V R  E+  A+ ++L KV      A+    E++  Q  L +  LQL+   Q + E   E
Sbjct: 839  QVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAE 898

Query: 672  AASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQR 731
            A  LR  LT ++    Q L+E   ++E R+ E+    E R    + E  K   ++++++ 
Sbjct: 899  AEELRARLTAKK----QELEEICHDLEARVEEE----EERCQHLQAEKKKMQQNIQELEE 950

Query: 732  RAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEGLLSRYKQQRLL 791
            +  +E+   Q+L+   E+   E   +     Q +  D+N  LA   +E  L   +     
Sbjct: 951  QLEEEESARQKLQ--LEKVTTEAKLKKLEEEQIILEDQNCKLA---KEKKLLEDRIAEFT 1005

Query: 792  TVLPSLLDKKKSVVSSPRPPEC---SASAPVAAAVPTRESIKGSLSVLLDDLQDLSEAIS 848
            T L    +K KS+       E         +      R+ ++ +   L  D  DLS+ I+
Sbjct: 1006 TNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIA 1065

Query: 849  KEEA 852
            + +A
Sbjct: 1066 ELQA 1069


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score =  108 bits (269), Expect = 3e-23
 Identities = 177/777 (22%), Positives = 320/777 (41%), Gaps = 127/777 (16%)

Query: 174  QALSQQAEVIVRQLQELRRLEEEVR----------LLRETSLQQKMRLEAQAMELEALAR 223
            Q    QA++   +LQ L + EEE++          L +  +L+    L+AQ  EL+    
Sbjct: 1070 QIAELQAQIDELKLQ-LAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFE 1128

Query: 224  AEKAGRAEAEGLRAALAGA-EVVRKNLEE-----GSQREL---------------EEVQR 262
            +EKA R +AE  +  L+   E ++  LE+      +Q+EL               EE  +
Sbjct: 1129 SEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETK 1188

Query: 263  LHQEQLSSLTQAHEEALSSLTSKAE-------GLEKSLSSLET---RRAGEAKELAEAQR 312
             H+ Q+  + Q H  AL  L+ + E        LEK+   LET     A E K L + + 
Sbjct: 1189 NHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKA 1248

Query: 313  EAELLRKQLSKTQEDLEAQVTLVENLRKYVGE---QVPSEVHSQTWELE--RQKLLETMQ 367
            E+E  RK+L    ++L A+V+  + LR  + E   ++ +E+ + +  LE   +K ++  +
Sbjct: 1249 ESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAK 1308

Query: 368  HLQEDRDSLHATAELLQVRVQSLTHILA--LQEEELTRKVQPSDSLEPEFTRKCQSLLNR 425
                    L  T ELLQ   +   ++ +   Q EE    +Q     E E  +  +     
Sbjct: 1309 DAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLE----- 1363

Query: 426  WREKVFALMVQLK------AQELEHSDSVKQLKGQVASLQEKVTSQSQEQAI-------- 471
              ++V AL  QL         +L   +S+++ K ++    E ++ + +E+A+        
Sbjct: 1364 --KQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKT 1421

Query: 472  ---LQRSLQDKAAEVEVERMGAKGLQLE-------LSRAQEARRRWQQQTASAEEQLR-L 520
               LQ+ L D   +++ +R  A  L+ +       L+  +    R+ ++   AE + R  
Sbjct: 1422 KNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREK 1481

Query: 521  VVNAVSSSQIWLETTMAKVE------GAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALA 574
               A+S ++   E   AK E         A +  L +      + VH +      K AL 
Sbjct: 1482 ETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELE---KSKRALE 1538

Query: 575  QLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQLS 634
            Q  +E   +   + ++  ELQ   + + RL+  +Q      ++++    EQ E +++ L 
Sbjct: 1539 QQVEE---MRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLI 1595

Query: 635  KVAQQLEQELQQTQE--------------SLASLGLQLEVARQGQ--------------- 665
            K  ++LE EL+  ++               L  L  Q+E A + +               
Sbjct: 1596 KQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMK 1655

Query: 666  --QESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTE--RRLNEARREHAK 721
              Q   EEA + R E+  Q +   + L+   AE+  +L+E+L+ +E  RR  E  R+   
Sbjct: 1656 DYQRELEEARASRDEIFAQSKESEKKLKSLEAEI-LQLQEELASSERARRHAEQERDELA 1714

Query: 722  AVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEGL 781
              ++     + A  +++R  E R  Q E   EE Q     L +  R   L + TL  E  
Sbjct: 1715 DEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELA 1774

Query: 782  LSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGSLSVLLD 838
              R   Q+       L  + K + +  +  E +  +   A +   E+  G L   L+
Sbjct: 1775 AERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLE 1831



 Score =  105 bits (261), Expect = 2e-22
 Identities = 166/716 (23%), Positives = 294/716 (41%), Gaps = 101/716 (14%)

Query: 183  IVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAME------------LEALARAEKAGRA 230
            + RQ +EL+  +EE  LL+    Q K+  E + ME            L    +AE    A
Sbjct: 847  VTRQEEELQAKDEE--LLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFA 904

Query: 231  EAEGLRAALAG----AEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKA 286
            EAE +RA LA      E +  +LE   + E E  Q L  E+     QAH + L     + 
Sbjct: 905  EAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEK--KKMQAHIQDLEEQLDEE 962

Query: 287  EG------LEKSLSSLETRRAGEAKELAEAQ-----REAELLRKQLSKTQEDLEAQVTLV 335
            EG      LEK  +  + ++  E   L E Q     +E +L+  ++++    L  +    
Sbjct: 963  EGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKA 1022

Query: 336  ENLRKYVGEQ----VPSEVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQSLT 391
            +NL K   +Q       E   +  E  RQ+L +  + L  +   L      LQ ++  L 
Sbjct: 1023 KNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELK 1082

Query: 392  HILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQL 451
              LA +EEEL                  Q  L R  ++       LK         V++L
Sbjct: 1083 LQLAKKEEEL------------------QGALARGDDETLHKNNALKV--------VREL 1116

Query: 452  KGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQT 511
            + Q+A LQE   S+   +   ++  +D + E+E  +   +      +  QE R + +Q+ 
Sbjct: 1117 QAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEV 1176

Query: 512  A----SAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLI 567
            A    + EE+ +     +   +    T + ++     Q       L    + + T    +
Sbjct: 1177 AELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKEL 1236

Query: 568  ARKL-ALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQE---VGRAR 623
            A ++  L Q++ ES      +     EL     E +RL  EL   A  +Q E   V    
Sbjct: 1237 ACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLL 1296

Query: 624  EQGEAERQQLSKVAQQLEQELQQTQE----------SLASLGLQLEVARQGQQESTEEAA 673
            E+ E +  + +K A  LE +LQ TQE          +L+S   QLE  +   QE  EE  
Sbjct: 1297 EEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEE 1356

Query: 674  SLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQ-IQRR 732
              R+ L +Q      ALQ ++A+ + ++ + L   E  L EA+++  K   +L Q ++ +
Sbjct: 1357 EARKNLEKQV----LALQSQLADTKKKVDDDLGTIE-SLEEAKKKLLKDAEALSQRLEEK 1411

Query: 733  AAQEKERSQELRRLQEE-----ARKEEGQRLARRLQELERDKNLMLATLQQEGLLSRYKQ 787
            A    +  +   RLQ+E        +  +++A  L++ ++  + +LA  +++ + +RY +
Sbjct: 1412 ALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLA--EEKSISARYAE 1469

Query: 788  QRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGSLSVLLDDLQDL 843
            +R         D+ ++          S +  +  A+  +E  +     L  D++DL
Sbjct: 1470 ER---------DRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDL 1516



 Score = 93.6 bits (231), Expect = 7e-19
 Identities = 148/675 (21%), Positives = 281/675 (41%), Gaps = 122/675 (18%)

Query: 191  RRLEEEVRLLRETSLQ---QKMRLEAQAMELEA---------LARAEKAGRAEAEGLRAA 238
            + L  EV++L++   +   ++ +L+AQ  EL A         +  AEKA + + E    +
Sbjct: 1234 KELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVS 1293

Query: 239  LAGAEVVRKNLEEGS-----QRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSL 293
                E  +K ++        + +L++ Q L QE+             +L+S+   LE+  
Sbjct: 1294 TLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKL--------NLSSRIRQLEEEK 1345

Query: 294  SSLETRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVP-SEVHS 352
            +SL+ ++  E +     +++   L+ QL+ T++ ++  +  +E+L +   + +  +E  S
Sbjct: 1346 NSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALS 1405

Query: 353  QTWE---LERQKLLETMQHLQEDRDSL-------HATAELLQVRVQSLTHILALQEEELT 402
            Q  E   L   KL +T   LQ++ D L          A  L+ + +    +LA ++    
Sbjct: 1406 QRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISA 1465

Query: 403  RKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKV 462
            R  +  D  E E   K    L+  R    AL   L+A+E E     KQL+  +  L    
Sbjct: 1466 RYAEERDRAEAEAREKETKALSLAR----ALEEALEAKE-EFERQNKQLRADMEDLMSSK 1520

Query: 463  TSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRW--------------- 507
                +    L++S +    +VE  R   + L+ EL   ++A+ R                
Sbjct: 1521 DDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDL 1580

Query: 508  QQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLI 567
            Q +    EE+ RL++  V   +  LE    +   A A    +   L     ++       
Sbjct: 1581 QTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANK-- 1638

Query: 568  ARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAE---------------LQLSA 612
            AR   + QLR+    L   + D   EL++ R  R+ + A+               LQL  
Sbjct: 1639 ARDEVIKQLRK----LQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQE 1694

Query: 613  RLIQQEVGRAREQGEAERQQLS----------------------KVAQQLEQELQQTQES 650
             L   E  RAR   E ER +L+                      ++AQ LE+EL++ Q +
Sbjct: 1695 ELASSE--RARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQ-LEEELEEEQSN 1751

Query: 651  LASLG-------LQLEVARQ---GQQESTEEAASLRQELTQQQELYGQALQEKVAEVETR 700
            +  L        LQ++        ++ + +++ + RQ+L +Q +     LQE    V+++
Sbjct: 1752 MELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSK 1811

Query: 701  LREQLSDTERR---LNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEAR-----K 752
             +  +S  E +   L E   + AK   +  ++ RR   EK+  +   ++++E R     K
Sbjct: 1812 FKATISALEAKIGQLEEQLEQEAKERAAANKLVRRT--EKKLKEIFMQVEDERRHADQYK 1869

Query: 753  EEGQRLARRLQELER 767
            E+ ++   R+++L+R
Sbjct: 1870 EQMEKANARMKQLKR 1884



 Score = 91.3 bits (225), Expect = 4e-18
 Identities = 130/612 (21%), Positives = 264/612 (43%), Gaps = 71/612 (11%)

Query: 171  EGSQALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRA 230
            E +Q L  + + +   +Q+L     E +L  E   +QK++LE    E +     E+    
Sbjct: 936  ERNQILQNEKKKMQAHIQDL-----EEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLL 990

Query: 231  EAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLE 290
            E +  +  +   +++   + E S +  EE ++   + L+ +    E  +S L  + +  E
Sbjct: 991  EDQNSKF-IKEKKLMEDRIAECSSQLAEEEEKA--KNLAKIRNKQEVMISDLEERLKKEE 1047

Query: 291  KSLSSLETRRA---GEAKEL----AEAQREAELLRKQLSKTQEDLEAQVTL--VENLRKY 341
            K+   LE  +    GE  +L    AE Q + + L+ QL+K +E+L+  +     E L K 
Sbjct: 1048 KTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKN 1107

Query: 342  VGEQVPSEVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEEL 401
               +V  E+ +Q  E            LQED +S  A+    + + + L+      EE  
Sbjct: 1108 NALKVVRELQAQIAE------------LQEDFESEKASRNKAEKQKRDLS------EELE 1149

Query: 402  TRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEK 461
              K +  D+L+   T   Q L  +  ++V  L   L+ +   H   ++ ++ + A+  E+
Sbjct: 1150 ALKTELEDTLDT--TAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEE 1207

Query: 462  VTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLV 521
            ++ Q ++    + +L+     +E +    K L  E+   Q+ +   + +    + Q++ +
Sbjct: 1208 LSEQLEQAKRFKANLEKNKQGLETDN---KELACEVKVLQQVKAESEHKRKKLDAQVQEL 1264

Query: 522  VNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESC 581
               VS           K      +L +++  L  A +K     G+        +  +++ 
Sbjct: 1265 HAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKK-----GI--------KFAKDAA 1311

Query: 582  PLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAE---RQQLSKVAQ 638
             L   + D     Q+L +E  R    L    R +++E    +EQ E E   R+ L K   
Sbjct: 1312 SLESQLQDT----QELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVL 1367

Query: 639  QLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVE 698
             L+ +L  T++ +      +E   + +++  ++A +L Q L ++   Y     +K+ + +
Sbjct: 1368 ALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAY-----DKLEKTK 1422

Query: 699  TRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERS----QELRRLQEEARKEE 754
             RL+++L D    L+  R+  +      ++  +  A+EK  S    +E  R + EAR++E
Sbjct: 1423 NRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKE 1482

Query: 755  GQ--RLARRLQE 764
             +   LAR L+E
Sbjct: 1483 TKALSLARALEE 1494



 Score = 87.4 bits (215), Expect = 5e-17
 Identities = 137/676 (20%), Positives = 286/676 (42%), Gaps = 78/676 (11%)

Query: 171  EGSQALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRA 230
            E   +L +Q E    + +  + LE++V  L+      K +++     +E+L  A+K    
Sbjct: 1343 EEKNSLQEQQE---EEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLK 1399

Query: 231  EAEGLRAALAGAEVVRKNLEEGSQRELEEVQRL-----HQEQLSSLTQAHEEALSSLTSK 285
            +AE L   L    +    LE+   R  +E+  L     HQ Q++S  +  ++    L ++
Sbjct: 1400 DAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAE 1459

Query: 286  AEGLEKSLSSLETRRAGEAKE-------LAEAQREAELLRKQLSKTQEDLEAQVTLVENL 338
             + +    +    R   EA+E       LA A  EA   +++  +  + L A +  + + 
Sbjct: 1460 EKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSS 1519

Query: 339  RKYVGEQVPSEVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQE 398
            +  VG+ V                      L++ + +L    E ++ +++ L   L   E
Sbjct: 1520 KDDVGKNV--------------------HELEKSKRALEQQVEEMRTQLEELEDELQATE 1559

Query: 399  EELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASL 458
            +   R      +++ +F R  Q+   +  EK   L+ Q++  E E  D  KQ    VAS 
Sbjct: 1560 DAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASK 1619

Query: 459  QEKVTSQSQEQAILQRSLQDKAAEVEVERMGA-----KGLQLELSRAQEARRRWQQQTAS 513
            ++        +A ++ +  +KA +  ++++       K  Q EL  A+ +R     Q+  
Sbjct: 1620 KKMEIDLKDLEAQIEAA--NKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKE 1677

Query: 514  AEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIA---RK 570
            +E++L+    ++ +  + L+  +A  E A        + L+  +    + +  +    R+
Sbjct: 1678 SEKKLK----SLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRR 1733

Query: 571  LA--LAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEA 628
            L   +AQL +E   L    +++ L   + R+   ++D    L+A L  +    A ++ + 
Sbjct: 1734 LEARIAQLEEE---LEEEQSNMELLNDRFRKTTLQVDT---LNAELAAER--SAAQKSDN 1785

Query: 629  ERQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQ 688
             RQQL +  ++L+ +LQ+ + ++ S       A + +    EE   L QE  ++      
Sbjct: 1786 ARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEE--QLEQEAKERA----- 1838

Query: 689  ALQEKVAEVETRLRE---QLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQEL-- 743
            A  + V   E +L+E   Q+ D  R  ++ + +  KA   ++Q++R+  + +E +     
Sbjct: 1839 AANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANA 1898

Query: 744  --RRLQEEA--RKEEGQRLARRLQELE---RDKNLMLATLQQEGLLSRYKQQRLLTVLPS 796
              R+LQ E     E  + L+R +  L+   R    +  +  + G    + +   L +   
Sbjct: 1899 SRRKLQRELDDATEANEGLSREVSTLKNRLRRGGPISFSSSRSGRRQLHLEGASLELSDD 1958

Query: 797  LLDKKKSVVSSPRPPE 812
              + K S V+  +PP+
Sbjct: 1959 DTESKTSDVNETQPPQ 1974



 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 93/443 (20%), Positives = 200/443 (45%), Gaps = 37/443 (8%)

Query: 136  SERRLDTQRPQVTMWERDVSSDRQEPGRRGRSWGLEGSQ-ALSQQAEVIVRQLQELRRLE 194
            ++   + Q  Q+     D+ S + + G+      LE S+ AL QQ E +  QL+EL   E
Sbjct: 1498 AKEEFERQNKQLRADMEDLMSSKDDVGKNVHE--LEKSKRALEQQVEEMRTQLEEL---E 1552

Query: 195  EEVRLLRETSLQQKMRLEAQAMELEALARA-----EKAGRAEAEGLRAALAGAEVVRKN- 248
            +E++   +  L+ ++ ++A   + E   +      E+  R   + +R   A  E  RK  
Sbjct: 1553 DELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQR 1612

Query: 249  -LEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKEL 307
             L   S++++E   +  + Q+ +  +A +E +  L      ++     LE  RA   +  
Sbjct: 1613 ALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIF 1672

Query: 308  A---EAQREAELLRKQLSKTQEDLEAQVTL---VENLRKYVGEQVPSEVHSQTWELERQK 361
            A   E++++ + L  ++ + QE+L +        E  R  + +++ +    ++  L+ ++
Sbjct: 1673 AQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKR 1732

Query: 362  LLET-MQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRK---VQPSDSLEPEFTR 417
             LE  +  L+E+ +   +  ELL  R +  T  +     EL  +    Q SD+   +  R
Sbjct: 1733 RLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLER 1792

Query: 418  KCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAIL----- 472
            + + L  + +E   A+  + KA       ++  L+ ++  L+E++  +++E+A       
Sbjct: 1793 QNKELKAKLQELEGAVKSKFKA-------TISALEAKIGQLEEQLEQEAKERAAANKLVR 1845

Query: 473  --QRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQI 530
              ++ L++   +VE ER  A   + ++ +A    ++ ++Q   AEE+      +    Q 
Sbjct: 1846 RTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQR 1905

Query: 531  WLETTMAKVEGAAAQLPSLNNRL 553
             L+      EG + ++ +L NRL
Sbjct: 1906 ELDDATEANEGLSREVSTLKNRL 1928



 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 93/448 (20%), Positives = 194/448 (43%), Gaps = 23/448 (5%)

Query: 316  LLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQHLQEDRDS 375
            L RK  +K Q+ L A   L  N   Y+  +     H Q W +   K+   +Q  +++ + 
Sbjct: 801  LARKAFAKKQQQLSALKVLQRNCAAYLKLR-----HWQWWRVFT-KVKPLLQVTRQEEEL 854

Query: 376  LHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMV 435
                 ELL+V+ +     +  + EE+ RK Q     +     + Q+    + E    +  
Sbjct: 855  QAKDEELLKVKEKQTK--VEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAE-EMRA 911

Query: 436  QLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQL 495
            +L A++ E  + +  L+ +V   +E+      E+  +Q  +QD   +++ E    + LQL
Sbjct: 912  RLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQL 971

Query: 496  ELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWL---ETTMAKVEGAAAQLPSLNNR 552
            E   A+   ++ +++    E+Q    +      +  +    + +A+ E  A  L  + N+
Sbjct: 972  EKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNK 1031

Query: 553  LSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSA 612
                +  +     L   +    +L +    L    TD+  ++ +L+ + + L  +L    
Sbjct: 1032 QEVMISDLE--ERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKE 1089

Query: 613  RLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEA 672
              +Q  + R  ++    +    KV ++L+ ++ + QE   S       A + +++ +EE 
Sbjct: 1090 EELQGALARGDDE-TLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEEL 1148

Query: 673  ASLRQEL-------TQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHAKAVVS 725
             +L+ EL         QQEL  +  QE VAE++  L E+  + E ++ + R+ HA A+  
Sbjct: 1149 EALKTELEDTLDTTAAQQELRTKREQE-VAELKKALEEETKNHEAQIQDMRQRHATALEE 1207

Query: 726  LRQIQRRAAQEKERSQELRRLQEEARKE 753
            L +   +A + K   ++ ++  E   KE
Sbjct: 1208 LSEQLEQAKRFKANLEKNKQGLETDNKE 1235



 Score = 43.5 bits (101), Expect = 9e-04
 Identities = 45/203 (22%), Positives = 93/203 (45%), Gaps = 11/203 (5%)

Query: 592  LELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESL 651
            L++ +  EE    D EL L  +  Q +V    E+ E + QQL +    L ++LQ   E  
Sbjct: 845  LQVTRQEEELQAKDEEL-LKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELF 903

Query: 652  ASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETR---LREQLSDT 708
            A    ++      +++  EE     +   +++E   Q LQ +  +++     L EQL + 
Sbjct: 904  AEAE-EMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEE 962

Query: 709  ERRLNEARREHAKAVVSLRQIQRRAAQEKERSQEL---RRLQEEARKEEGQRLARRLQEL 765
            E    + + E   A   +++++      ++++ +    ++L E+   E   +LA   +E 
Sbjct: 963  EGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLA---EEE 1019

Query: 766  ERDKNLMLATLQQEGLLSRYKQQ 788
            E+ KNL     +QE ++S  +++
Sbjct: 1020 EKAKNLAKIRNKQEVMISDLEER 1042



 Score = 34.3 bits (77), Expect = 0.52
 Identities = 32/144 (22%), Positives = 66/144 (45%), Gaps = 10/144 (6%)

Query: 723 VVSLRQIQRRAAQEKERSQELRRLQEEARKEEG--QRLARRLQELERDKNLMLATLQQEG 780
           V  L Q+ R+  + + + +EL +++E+  K EG  + + R+ Q+L  +KN++   LQ E 
Sbjct: 841 VKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAET 900

Query: 781 LLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGSLSVLLDDL 840
            L    ++    +   L  KK+ +       E    + V       + ++     +   +
Sbjct: 901 ELFAEAEE----MRARLAAKKQELEEILHDLE----SRVEEEEERNQILQNEKKKMQAHI 952

Query: 841 QDLSEAISKEEAVCQGDNLDRCSS 864
           QDL E + +EE   Q   L++ ++
Sbjct: 953 QDLEEQLDEEEGARQKLQLEKVTA 976


>gi|45439327 periplakin [Homo sapiens]
          Length = 1756

 Score =  107 bits (266), Expect = 6e-23
 Identities = 164/708 (23%), Positives = 310/708 (43%), Gaps = 90/708 (12%)

Query: 181  EVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALA 240
            EV     Q L+ LE  + LLR+   Q ++ +  + ++         +G  EA  +R  L 
Sbjct: 848  EVYAINRQRLQNLEFALNLLRQ---QPEVEVTHETLQ----RNRPDSGVEEAWKIRKELD 900

Query: 241  GAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRR 300
                 R+ LE   +   EE+  L + Q    +   +E L  +      LE+S   L+   
Sbjct: 901  EETERRRQLENEVKSTQEEIWTL-RNQGPQESVVRKEVLKKVPDPV--LEESFQQLQ--- 954

Query: 301  AGEAKELAEAQREAELLRKQLSKTQEDLEA-QVTLVENLRKYVGEQVPSEVHSQTWELER 359
                + LAE Q + +LL+++L   Q  L A +    +  ++YV ++V      +    E 
Sbjct: 955  ----RTLAEEQHKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEVLRIEPDRAQADEV 1010

Query: 360  QKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKC 419
             +L E ++ L+  + +  A   LLQ RV +L    +  +E++T K       +P+   + 
Sbjct: 1011 LQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEY 1070

Query: 420  QSLLNRWREKVFALMVQLKAQELEH----SDSVKQLKGQVASLQEKVTSQS----QEQAI 471
            Q L    + +      QL+ ++ E      D +K+L+ + A  + K+T +     ++ A 
Sbjct: 1071 QQLQEDHQRQD-----QLREKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAA 1125

Query: 472  LQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASA----EEQLRLVV----- 522
             +R + D   + E E   A+  Q E  + +  R+ W  +  +A    +E++R +V     
Sbjct: 1126 TEREVSDLTRQYEDEAAKARASQRE--KTELLRKIWALEEENAKVVVQEKVREIVRPDPK 1183

Query: 523  --NAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQES 580
              + V++ ++ L     K  GA  QL S  + L    R+   +     +++    ++ ++
Sbjct: 1184 AESEVANLRLELVEQERKYRGAEEQLRSYQSELEALRRRGPQVE---VKEVTKEVIKYKT 1240

Query: 581  CPLPPPVTDVSLELQQLREE---RNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVA 637
             P      ++  ELQ+LREE   + RL     L    +++E+   ++     + Q  +V 
Sbjct: 1241 DP------EMEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQALKDT--KPQVQTKEVV 1292

Query: 638  QQLEQ--ELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQE----LYGQALQ 691
            Q++ Q  E  QT+E +ASL  +L   ++ Q +   E AS  +++ +++E    +  + +Q
Sbjct: 1293 QEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELSRVKERVVQ 1352

Query: 692  EKVA--EVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEE 749
            ++V   E E  LR + S     ++   R+  K    LR++QRR  + + + +EL R  E 
Sbjct: 1353 QEVVRYEEEPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELER--ER 1410

Query: 750  ARKEEGQRLARRLQELERDKNLMLATLQQEGLLSRYKQQRLLTVLPSLLDKKKSVVSSPR 809
              + E +R  +RLQ+        LA L+QE   +R K           +   + VV    
Sbjct: 1411 QARREAEREVQRLQQ-------RLAALEQEEAEAREK-----------VTHTQKVVLQQD 1452

Query: 810  PPECSASAPVAAAVP----TRESIKGSLSVLLDDLQDLSEAISKEEAV 853
            P +    A +   +      R+ ++G L  L   L  L +A  KE+ V
Sbjct: 1453 PQQAREHALLRLQLEEEQHRRQLLEGELETLRRKLAALEKAEVKEKVV 1500



 Score = 87.8 bits (216), Expect = 4e-17
 Identities = 162/699 (23%), Positives = 301/699 (43%), Gaps = 116/699 (16%)

Query: 186  QLQELRRLEEEVRLLRETSLQQKMRLEAQAMELE--ALARAEKAGRAEAEGLRAALAGAE 243
            Q  E+ +L EE+  LR    +QK   EA+ + L+    A AE+  RA+ +     +   E
Sbjct: 1006 QADEVLQLREELEALR----RQKGAREAEVLLLQQRVAALAEEKSRAQEK-----VTEKE 1056

Query: 244  VVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGE 303
            VV+   +   + E +++Q  HQ Q   L +  EE LS L  K + LEK            
Sbjct: 1057 VVKLQNDPQLEAEYQQLQEDHQRQ-DQLREKQEEELSFLQDKLKRLEKE----------- 1104

Query: 304  AKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLL 363
                  A  E ++  K++ K ++D   +  + +  R+Y  E   +    +    E+ +LL
Sbjct: 1105 -----RAMAEGKITVKEVLKVEKDAATEREVSDLTRQYEDEAAKARASQR----EKTELL 1155

Query: 364  ETMQHLQEDRDSLHATAELLQV-----RVQSLTHILALQEEELTRKVQPSDSLEPEFTRK 418
              +  L+E+   +    ++ ++     + +S    L L+  E  RK + ++    E  R 
Sbjct: 1156 RKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQERKYRGAE----EQLRS 1211

Query: 419  CQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQR-SLQ 477
             QS L   R +   + V+   +E+    +  +++ ++  L+E++  +++   +++R  L+
Sbjct: 1212 YQSELEALRRRGPQVEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTR---LIERCDLE 1268

Query: 478  DKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEE--QLRLVVNAVSSSQIWLETT 535
                + E++ +     Q++     +   ++Q+   + EE   LR  ++     Q+ LE  
Sbjct: 1269 IYQLKKEIQALKDTKPQVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERE 1328

Query: 536  MAKVEGAAAQLPSLNNRLSYAVRKVHTIR-----GLIARKLALAQLRQESCPLPPPVTDV 590
             A  E   A+     +R+   V +   +R     GL A   A A+              +
Sbjct: 1329 RASQEEQIARKEEELSRVKERVVQQEVVRYEEEPGLRAEASAFAE-------------SI 1375

Query: 591  SLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQES 650
             +EL+Q+    ++L AEL+   R  + E+ R  E+ E ERQ      ++ E+E+Q+ Q+ 
Sbjct: 1376 DVELRQI----DKLRAELRRLQRR-RTELERQLEELERERQ----ARREAEREVQRLQQR 1426

Query: 651  LASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTER 710
            LA+L               +E A  R+++T  Q++  Q   ++  E    LR QL + + 
Sbjct: 1427 LAAL--------------EQEEAEAREKVTHTQKVVLQQDPQQARE-HALLRLQLEEEQH 1471

Query: 711  R-------LNEARREHA---KAVVSLRQIQRRAAQ--EKERSQELRR----LQEEARKE- 753
            R       L   RR+ A   KA V  + +   + Q  + +  QE++R    L+EE+R + 
Sbjct: 1472 RRQLLEGELETLRRKLAALEKAEVKEKVVLSESVQVEKGDTEQEIQRLKSSLEEESRSKR 1531

Query: 754  ----EGQRLARRLQELE---RDKNLMLATLQQEGLLSRYKQQRLLTVLPSLLDKKKSVVS 806
                E  RL  RL ELE      +  L  L++E    + ++Q L      L  +     +
Sbjct: 1532 ELDVEVSRLEARLSELEFHNSKSSKELDFLREENHKLQLERQNLQLETRRLQSEINMAAT 1591

Query: 807  SPRPPECSASAPVAAAVPTRESIKGSLSVLLDDLQDLSE 845
              R      +  VA +    +S   SL   LDDL+ LS+
Sbjct: 1592 ETRD---LRNMTVADSGTNHDSRLWSLERELDDLKRLSK 1627



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 105/525 (20%), Positives = 222/525 (42%), Gaps = 42/525 (8%)

Query: 155  SSDRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQ 214
            +S R++     + W LE   A     E +   ++   + E EV  LR   ++Q+ +    
Sbjct: 1146 ASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQERKYRGA 1205

Query: 215  AMELEALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLHQE--QLSSLT 272
              +L +     +A R     +       EV++   +   ++EL   QRL +E    + L 
Sbjct: 1206 EEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPEMEKEL---QRLREEIVDKTRLI 1262

Query: 273  QAHEEALSSLTSKAEGLEKSLSSLETRR-AGEAKELAEAQREAELLRKQLSKTQEDLEAQ 331
            +  +  +  L  + + L+ +   ++T+    E  +  E  +  E +    +K  E+ + Q
Sbjct: 1263 ERCDLEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQ 1322

Query: 332  VTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQHLQED--RDSLHATAELLQVRVQS 389
            V L E  R    EQ+  +    +   ER    E +++ +E   R    A AE + V ++ 
Sbjct: 1323 VDL-ERERASQEEQIARKEEELSRVKERVVQQEVVRYEEEPGLRAEASAFAESIDVELRQ 1381

Query: 390  LTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVK 449
            +  + A       R+ +    LE E  R+ Q+     RE V  L  +L A E E +++ +
Sbjct: 1382 IDKLRAELRRLQRRRTELERQLE-ELERERQARREAERE-VQRLQQRLAALEQEEAEARE 1439

Query: 450  QLKGQVASLQEKVTSQSQEQAILQRSLQD-----KAAEVEVERMGAKGLQLELSRAQE-- 502
            ++      + ++   Q++E A+L+  L++     +  E E+E +  K   LE +  +E  
Sbjct: 1440 KVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEGELETLRRKLAALEKAEVKEKV 1499

Query: 503  -ARRRWQQQTASAEEQLRLVVNAV---SSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVR 558
                  Q +    E++++ + +++   S S+  L+  ++++E   ++L   N++ S    
Sbjct: 1500 VLSESVQVEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSS---- 1555

Query: 559  KVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQE 618
                          L  LR+E+  L     ++ LE ++L+ E N    E +    +   +
Sbjct: 1556 ------------KELDFLREENHKLQLERQNLQLETRRLQSEINMAATETRDLRNMTVAD 1603

Query: 619  VGRAREQG----EAERQQLSKVAQQLEQELQQTQESLASLGLQLE 659
             G   +      E E   L ++++  + E+ + Q+ L S+ ++ E
Sbjct: 1604 SGTNHDSRLWSLERELDDLKRLSKDKDLEIDELQKRLGSVAVKRE 1648


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score =  106 bits (265), Expect = 8e-23
 Identities = 195/826 (23%), Positives = 341/826 (41%), Gaps = 151/826 (18%)

Query: 133  QDVSERRLDTQ------RPQVTMWERDVSSDRQEPGR-RGRSWGLEGSQALSQQAEVIVR 185
            Q + ER  DT+        ++   +R +S +++E  +  G+   LE    L +  E +  
Sbjct: 1267 QKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESE--LMELHETMAS 1324

Query: 186  QLQELRRLE---EEVRLLRETSLQQKMRLEAQAMEL-----EALARAEKAGRAEAEGLRA 237
                LRR E    E +  RE     K  L AQ   L     EA A+A  AG  E E LR 
Sbjct: 1325 LQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILE-EDLRT 1383

Query: 238  ALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLE 297
            A +  ++  KN E  S+RE  +  +   E   +  +A +E L+ LT      E+ + +L 
Sbjct: 1384 ARSALKL--KNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLR 1441

Query: 298  TRRAGEAKELAEAQREA-----ELLRKQLSKTQEDLEAQVTLVENLRKY--VGEQVPSEV 350
                G+ +EL E QRE      ELL   L K  ++++ Q   ++ L K   V E +P  V
Sbjct: 1442 ----GQIQEL-EKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAV 1496

Query: 351  HSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQE---EELTRKVQP 407
              +  +L  Q+  E ++ L++DR++     E   + ++    ++  Q    ++L +++  
Sbjct: 1497 QEREQKLTVQR--EQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVT 1554

Query: 408  SDSLEPEFTR-----KCQSLLNR----WREKVFALMVQLKAQELEHSDSVKQLKGQVASL 458
             + L  E        +CQ  L +     RE     +  L     E S  ++    Q+  L
Sbjct: 1555 LECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDL 1614

Query: 459  QEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQL 518
            +   T       +L R LQ++  EV+ +R   + LQ +     +   R  Q+    +E++
Sbjct: 1615 ESHST-------VLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERI 1667

Query: 519  RLVVNAVSSSQIWLETTMAKVEGA--------AAQLPSLNNRLSYAVRKVHTIRGLIAR- 569
            +++ +  +     LE  + +++ +          Q   +  R           RG +   
Sbjct: 1668 QVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHM 1727

Query: 570  KLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQ------------LSAR---- 613
            KL L    +E       V      + +L+E +++L+ +LQ            LS R    
Sbjct: 1728 KLILRDKEKE-------VECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEI 1780

Query: 614  -LIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEVAR------QGQQ 666
             ++QQ++  AREQGE + Q L       + +L + Q +LA    +LE  +      QGQ+
Sbjct: 1781 VVLQQQLQEAREQGELKEQSL-------QSQLDEAQRALAQRDQELEALQQEQQQAQGQE 1833

Query: 667  ESTEEAASLRQELTQQ-----QELYGQALQEKVAEVETRLREQLSDTERR---------- 711
            E  +E A   Q   +Q     +E +G+    K  E   RL E+L+   RR          
Sbjct: 1834 ERVKEKADALQGALEQAHMTLKERHGELQDHK--EQARRLEEELAVEGRRVQALEEVLGD 1891

Query: 712  LNEARREHAKAVVSLRQ----------IQRRAAQE---------KERSQELRRLQEEARK 752
            L    RE  KA+++L+Q          ++ RA Q+         KER QEL  L+ E++ 
Sbjct: 1892 LRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQS 1951

Query: 753  EEGQRLARRLQELERDKNLMLATLQQEGLLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPE 812
               Q  A R +     + L  A    +G     K+Q LL       +  +S+ +S    +
Sbjct: 1952 SRHQEEAARARAEALQEALGKAHAALQG-----KEQHLL----EQAELSRSLEASTATLQ 2002

Query: 813  CSASAPVAAAVPTRESIKGSLSVLLD-------DLQDLSEAISKEE 851
             S  A  A +    E+++     + D       D+Q L +A+++ +
Sbjct: 2003 ASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRD 2048



 Score =  106 bits (265), Expect = 8e-23
 Identities = 177/711 (24%), Positives = 315/711 (44%), Gaps = 97/711 (13%)

Query: 137  ERRLDTQRPQVTMWERDVSSDRQEPG-RRGRSWGLEGSQALSQQAEVIVRQL-QELRRLE 194
            E++ + Q+  + +   D+    QE   ++ +   LE  +++ +   + V++  Q+L    
Sbjct: 1448 EKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQR 1507

Query: 195  EEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQ 254
            E++R L +    Q+  LE Q +ELE   +  ++ R + + L+  L   E +   LEE + 
Sbjct: 1508 EQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEE-NH 1566

Query: 255  RELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSS-------LETRRAGEAKEL 307
             ++E  Q+L +E L    +    AL+ LT   E   + L +       LE+     A+EL
Sbjct: 1567 HKMECQQKLIKE-LEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLAREL 1625

Query: 308  AEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQ 367
             E  +E +  R+Q+ + Q   E    L ++L +   E +  +   Q   LE Q+  +T +
Sbjct: 1626 QERDQEVKSQREQIEELQRQKEH---LTQDLERRDQELMLQKERIQV--LEDQRTRQT-K 1679

Query: 368  HLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWR 427
             L+ED + +  +   L+ R + LT    L +E       PS +           L+ R +
Sbjct: 1680 ILEEDLEQIKLS---LRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEH--MKLILRDK 1734

Query: 428  EKVFALMVQLKAQELEHSDSVK-QLKGQVASLQEKV-------TSQSQEQAILQRSLQDK 479
            EK     V+ + + +     +K QL+ Q+  L  KV       + + QE  +LQ+ LQ+ 
Sbjct: 1735 EKE----VECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEA 1790

Query: 480  AAEVEVERMGAKGLQLELSRAQ----------EARRRWQQQTASAEEQLR----LVVNAV 525
              + E++    + LQ +L  AQ          EA ++ QQQ    EE+++     +  A+
Sbjct: 1791 REQGELKE---QSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGAL 1847

Query: 526  SSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTI---------------RGLIARK 570
              + + L+    +++    Q   L   L+   R+V  +               + L+A +
Sbjct: 1848 EQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQ 1907

Query: 571  LALAQLRQESCPLPPPVTDVSLELQQLREERNR----LDAELQLSARLIQQEVGRAREQ- 625
               A+  QE       + D  L+ Q + +ER++    L AE Q S    Q+E  RAR + 
Sbjct: 1908 QQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRH--QEEAARARAEA 1965

Query: 626  -----GEAERQQLSKVAQQLEQ-ELQQTQE-SLASLGLQLEVARQGQQESTEEAASLRQE 678
                 G+A      K    LEQ EL ++ E S A+L   L+ A Q      EEA  +++ 
Sbjct: 1966 LQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLD-ACQAHSRQLEEALRIQEG 2024

Query: 679  LTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKE 738
              Q Q+L     QE V +++  L ++  D E R  + R +  +  ++ R +Q    QEK+
Sbjct: 2025 EIQDQDL---RYQEDVQQLQQALAQR--DEELRHQQEREQLLEKSLAQR-VQENMIQEKQ 2078

Query: 739  RSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEGLLSRYKQQR 789
                   L +E  +EE + L + ++EL+    L LA  +QE L  R  QQR
Sbjct: 2079 N------LGQEREEEEIRGLHQSVRELQ----LTLAQKEQEILELRETQQR 2119



 Score =  106 bits (264), Expect = 1e-22
 Identities = 182/750 (24%), Positives = 318/750 (42%), Gaps = 104/750 (13%)

Query: 154 VSSDRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEA 213
           V +  +EP   GR  G E +Q L   A+    + +   R +E ++L  +  L+ K  L+ 
Sbjct: 225 VGAQSREPNGSGRMDGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLE-KAELQD 283

Query: 214 QAMELEAL-ARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLT 272
           +  EL AL  +++K      + ++A     E++  N  E  + E   + R  QE+  SL 
Sbjct: 284 RVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEAS-LSRNAQEEKLSLQ 342

Query: 273 QAHEEALSSLTSKAEGLEKSL---SSLETRRAGEAK-ELAEAQREAELLRKQLSKTQE-- 326
           Q  ++    +  + + + +     +SLE   +  ++ +  +A +   L+R  L++ ++  
Sbjct: 343 QVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAV 402

Query: 327 -DLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQV 385
            DL  Q+   +     + +Q     H Q WE E + L + +Q L  +RD+L      LQ 
Sbjct: 403 QDLRQQLAGCQEAVNLLQQQ-----HDQ-WEEEGKALRQRLQKLTGERDTLAGQTVDLQG 456

Query: 386 RVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHS 445
            V SL+     +E EL +K +     + E   +       WR +   + +QL+    +  
Sbjct: 457 EVDSLS-----KERELLQKAREELRQQLEVLEQ-----EAWRLRRVNVELQLQGDSAQ-- 504

Query: 446 DSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQ--LELSRAQ-E 502
                  GQ    QE++    +E+  LQ  L    A+          L+  LE S  + E
Sbjct: 505 -------GQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGE 557

Query: 503 ARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHT 562
             R+ Q +  +A  +    +  +SSS+  L+T +A +  AA +L +LN  L  A+ KV  
Sbjct: 558 LLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEAL--ALDKV-- 613

Query: 563 IRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGRA 622
             GL  + L L +  Q  C            ++   + RN L  +L   A   ++ +   
Sbjct: 614 --GLNQQLLQLEEENQSVCS----------RMEAAEQARNALQVDLA-EAEKRREALWEK 660

Query: 623 REQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQ 682
               EA+ Q+  +   +L+ +L+  QE    +  +L  +R  Q+ +T +   L QE  +Q
Sbjct: 661 NTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQ 720

Query: 683 QELYGQALQEKVAEV------ETRL------REQLSD-----------TERRLNEARREH 719
           +E+  +A+QEK A V      E RL      R+ L++            E  L EA++++
Sbjct: 721 EEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQN 780

Query: 720 AKAVVSLRQIQ---RRAAQEKERSQ-ELRRLQEEARKEEGQRLARRLQELERDKNL-MLA 774
           +   V+  Q++   +   Q KE  Q E+R L+ E   E  Q       E ERD     LA
Sbjct: 781 SVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQ------AEQERDAAARQLA 834

Query: 775 TLQQEGLLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGSLS 834
             +QEG  +  +Q+       + L +K     S    E      +A A+ + E  K  L 
Sbjct: 835 QAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQE------LAKALESLEREKMELE 888

Query: 835 VLLDDLQDLSEAI---------SKEEAVCQ 855
           + L + Q   EAI           E A+CQ
Sbjct: 889 MRLKEQQTEMEAIQAQREEERTQAESALCQ 918



 Score =  103 bits (256), Expect = 9e-22
 Identities = 144/628 (22%), Positives = 269/628 (42%), Gaps = 59/628 (9%)

Query: 171  EGSQALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAM-----ELEALARAE 225
            E S  LSQ+ + IV   Q+L+   E+  L +E SLQ ++    +A+     ELEAL + +
Sbjct: 1768 ETSLLLSQREQEIVVLQQQLQEAREQGEL-KEQSLQSQLDEAQRALAQRDQELEALQQEQ 1826

Query: 226  KAGRAE-------AEGLRAALAGAEVVRKNLEEGSQRELEEVQRLHQEQL--SSLTQAHE 276
            +  + +       A+ L+ AL  A +  K      Q   E+ +RL +E        QA E
Sbjct: 1827 QQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALE 1886

Query: 277  EALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVE 336
            E L  L +++   EK+L +L+       ++ AE  +E E+  + L  +   L+AQ  L E
Sbjct: 1887 EVLGDLRAESREQEKALLALQ-------QQCAEQAQEHEVETRALQDSW--LQAQAVLKE 1937

Query: 337  NLRKYVGEQVPSEVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILAL 396
              ++    +  S+      E  R +     + LQE     HA    LQ + Q L     L
Sbjct: 1938 RDQELEALRAESQSSRHQEEAARARA----EALQEALGKAHAA---LQGKEQHL-----L 1985

Query: 397  QEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVA 456
            ++ EL+R ++ S +        CQ+   +  E +     +++ Q+L + + V+QL+  +A
Sbjct: 1986 EQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALA 2045

Query: 457  SLQEKVTSQSQEQAILQRSLQDKAAE---VEVERMGAKGLQLELSRAQEARRRWQQQTAS 513
               E++  Q + + +L++SL  +  E    E + +G +  + E+    ++ R  Q   A 
Sbjct: 2046 QRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQ 2105

Query: 514  AEE---QLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVH-TIRGLIAR 569
             E+   +LR      +   +      + +E  + +L SL  RL   + ++   +R   AR
Sbjct: 2106 KEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAR 2165

Query: 570  K-----------LALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQE 618
            +           L+LAQ +     L      +   + +   E+ RL  EL+L+ R +++E
Sbjct: 2166 EIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKE 2225

Query: 619  VGRAREQGEAERQQLSKVAQQLEQ--ELQQTQESLASLGLQLEVARQGQQESTEEAASLR 676
              R    G     +L    +Q  Q  E+   +   +  G++ +  RQ  +   +  A L 
Sbjct: 2226 --RLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLE 2283

Query: 677  QELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQE 736
             + ++ Q  +   L+  + +VE   R+   +  R       E +KA  S    Q    Q+
Sbjct: 2284 IDRSRLQR-HNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQK 2342

Query: 737  KERSQELRRLQEEARKEEGQRLARRLQE 764
               ++ +  LQ+E    + Q    R Q+
Sbjct: 2343 NSDAKCVAELQKEVVLLQAQLTLERKQK 2370



 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 166/743 (22%), Positives = 320/743 (43%), Gaps = 95/743 (12%)

Query: 152  RDVSSDRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRL 211
            RD+  +++E  ++     L  S+   + A   + QL +  + +EEV L R  ++Q+K  L
Sbjct: 683  RDIQEEKEEIQKK-----LSESRHQQEAATTQLEQLHQEAKRQEEV-LAR--AVQEKEAL 734

Query: 212  EAQAMELEALARAEKAGRAE-AEGLRAALAGAEVVRKNLEEGSQRE--LEEVQRLHQEQL 268
              +   LE   +A +  R + AE L+   +  E++  +L E  Q+   +E  +   + Q+
Sbjct: 735  VREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQI 794

Query: 269  SSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQREAEL-LRKQLSKTQED 327
             ++TQA E     +      L+   S  E  R   A++LA+A++E +  L +Q +  +++
Sbjct: 795  QTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKE 854

Query: 328  LEAQVTLVENLRKYVGEQVPSEVHS---QTWELE-----RQKLLETMQHLQEDRDSLHAT 379
            +       E  R +  +++   + S   +  ELE     +Q  +E +Q  Q + +   A 
Sbjct: 855  VNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQ-AQREEERTQAE 913

Query: 380  AELLQVRVQ------SLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFAL 433
            + L Q++++      SL   L   ++EL    Q  + L  +   K Q L  + +E    L
Sbjct: 914  SALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDM--KVQKL--KEQETTGIL 969

Query: 434  MVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEV----EVERMG 489
              QL+  + E  ++ +Q +  +A+LQE+ +S  Q++  LQ+ ++D  +++    + +R+ 
Sbjct: 970  QTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLV 1029

Query: 490  AKGLQLELSRAQEARR---RWQQQTASA-------EEQLRLVVNAVSSSQIWLETTMAKV 539
             + +Q +L   QE  R     +++ AS        E++L ++  A S  Q  L      +
Sbjct: 1030 EQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDM 1089

Query: 540  EGAAAQLPSLNNRLSYAVRKVHTIRG-LIARKLALAQLRQESCPLPPPVTDVSLELQQLR 598
            + A  +   L+ ++    ++V       +A++  L +  + S      +T+  L      
Sbjct: 1090 QEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEAS-----HITEQQLRASLWA 1144

Query: 599  EERNRLDAELQLSARLIQQEVGRAREQ--GEAERQ-QLSKVAQQLEQELQQTQESLASLG 655
            +E      +L+L +   Q E   A +Q   +A+ Q QL+ +   L+Q L    ES   L 
Sbjct: 1145 QEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELS 1204

Query: 656  ---------LQLEVARQGQQE-----------STEEAASLRQELTQQQELYGQALQEKVA 695
                       LE  + G +            S E  AS   +L   Q+L+      K  
Sbjct: 1205 GGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKL--HQDLW------KTQ 1256

Query: 696  EVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEG 755
            +    LR+Q+   E RL +   E ++    L+ +QR+ +Q           QEE  K EG
Sbjct: 1257 QTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQN----------QEEKSKWEG 1306

Query: 756  QR--LARRLQELERDKNLMLATLQQEGLLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPEC 813
            ++  L   L EL      + + L++   L R + Q    +L +  +   + V   +    
Sbjct: 1307 KQNSLESELMELHETMASLQSRLRR-AELQRMEAQGERELLQAAKENLTAQVEHLQAAVV 1365

Query: 814  SASAPVAAAVPTRESIKGSLSVL 836
             A A  +AA    E ++ + S L
Sbjct: 1366 EARAQASAAGILEEDLRTARSAL 1388



 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 153/721 (21%), Positives = 295/721 (40%), Gaps = 130/721 (18%)

Query: 171  EGSQALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRA 230
            +  +AL+    V+ R+ Q ++ L +++   +E        L+ Q  + E   +A +    
Sbjct: 383  DADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAV----NLLQQQHDQWEEEGKALRQRLQ 438

Query: 231  EAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLE 290
            +  G R  LAG  V  +   +   +E E +Q+  +E    L    +EA        E L+
Sbjct: 439  KLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVE-LQ 497

Query: 291  KSLSSLETRRAGEAKELAEAQREAELLRKQL----SKTQEDLEAQVTLVENLRK--YVGE 344
                S + ++  + +EL  A RE E L++ L    +K  E L   +TL E L      GE
Sbjct: 498  LQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGE 557

Query: 345  QVPSEVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQ---VRVQSLTHILALQEEEL 401
             +  E    T  L R +  +++  L    ++L      L+   V++ +L   LAL +  L
Sbjct: 558  LLRQEQTEVTAALARAE--QSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGL 615

Query: 402  TRKVQPSDSLEPEFTRKCQSL----------------LNRWREKVFALMVQLKAQELEHS 445
             +++     LE E    C  +                  + RE ++     L+AQ  +  
Sbjct: 616  NQQLL---QLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAE 672

Query: 446  DSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLE--LSRAQEA 503
            ++  +L+  +  +QE+   +  ++ + +   Q +AA  ++E++  +  + E  L+RA + 
Sbjct: 673  EAGAELQADLRDIQEE--KEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQE 730

Query: 504  RRRWQQQTASAEEQLRLV----------VNAVSSSQIWLETTMAKVEGAAAQLPSLNNRL 553
            +    ++ A+ E +L+ V          +  +SS++  LE+++ + +   + +     +L
Sbjct: 731  KEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQL 790

Query: 554  SYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRL-----DAEL 608
               ++ V   + +I  ++   +L            ++  E  Q  +ER+        AE 
Sbjct: 791  EVQIQTVTQAKEVIQGEVRCLKL------------ELDTERSQAEQERDAAARQLAQAEQ 838

Query: 609  QLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQ-- 666
            +    L QQ+    +E  +  R++  K     +QEL +  ESL    ++LE+  + QQ  
Sbjct: 839  EGKTALEQQKAAHEKEVNQL-REKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTE 897

Query: 667  ------------------------ESTEEAASLRQELTQQQELYGQALQ----------- 691
                                    E+ +E  SL + L Q Q+    A Q           
Sbjct: 898  MEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKV 957

Query: 692  EKVAEVETR--LREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEK------------ 737
            +K+ E ET   L+ QL + +R L EA R+H   + +L++      Q+K            
Sbjct: 958  QKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKS 1017

Query: 738  -----ERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEGLLSRYKQQRLLT 792
                 + SQ L   + + +  E Q   R  +ELER+K  +  +L +       K+QRLL 
Sbjct: 1018 QLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLME-------KEQRLLV 1070

Query: 793  V 793
            +
Sbjct: 1071 L 1071



 Score = 38.1 bits (87), Expect = 0.036
 Identities = 43/184 (23%), Positives = 79/184 (42%), Gaps = 27/184 (14%)

Query: 175  ALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEK-------- 226
            A+  QA V+ R   E +RL++E+ L R    ++++         E  +R E+        
Sbjct: 2194 AMFLQASVLERD-SEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVS 2252

Query: 227  --------------AGRAEAEGLRAALAGAEVVRKNLEEGS---QRELEEVQRLHQEQLS 269
                          + R   E L+ A+A  E+ R  L+  +   +  LE+V+R  + +L 
Sbjct: 2253 GVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVER-ERRKLK 2311

Query: 270  SLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQREAELLRKQLSKTQEDLE 329
                   +A S   SKA     +      ++  +AK +AE Q+E  LL+ QL+  ++  +
Sbjct: 2312 REAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQ 2371

Query: 330  AQVT 333
              +T
Sbjct: 2372 DYIT 2375



 Score = 33.5 bits (75), Expect = 0.88
 Identities = 51/208 (24%), Positives = 88/208 (42%), Gaps = 37/208 (17%)

Query: 629 ERQQLSKVAQQLEQELQQTQESLASLGLQLEV-----------ARQGQQESTEEAASLRQ 677
           E   L ++  +LE+E QQ  ESLA +  QL +            R+  ++ T + +  R 
Sbjct: 92  EEPNLDELLVRLEEE-QQRCESLAEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRARD 150

Query: 678 ELTQQQE------------LYGQ-----ALQEKVAEVETRLREQLSDTERRLNEARREHA 720
           EL +++             L G+     +L  +V        E  S T+R L E + EH 
Sbjct: 151 ELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSATDRDLMELKAEHV 210

Query: 721 KAVVSLRQIQRR---AAQEKERSQELRRLQEEARKEEGQRLARRLQELER---DKNLMLA 774
           +   SL     R    AQ +E +   R   +     +   L  + QELE+   +++  L 
Sbjct: 211 RLSGSLLTCCLRLTVGAQSREPNGSGR--MDGREPAQLLLLLAKTQELEKEAHERSQELI 268

Query: 775 TLQQEGLLSRYKQQRLLTVLPSLLDKKK 802
            L+ +G L + + Q  +T L +LL + +
Sbjct: 269 QLKSQGDLEKAELQDRVTELSALLTQSQ 296


>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
          Length = 2003

 Score =  106 bits (264), Expect = 1e-22
 Identities = 171/721 (23%), Positives = 298/721 (41%), Gaps = 105/721 (14%)

Query: 175  ALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEG 234
            A  Q+ E++V +L+     EEE     +T   +K RL+    ELEA   AE+  R +   
Sbjct: 940  ARKQELELVVSELEARVGEEEECSRQMQT---EKKRLQQHIQELEAHLEAEEGARQK--- 993

Query: 235  LRAALAGAEVVRKNLEEG------SQRELEEVQRLHQEQL---SSLTQAHEEALSSLTS- 284
            L+      E   K  EE          +L + ++L +++L   SS     EE + SL   
Sbjct: 994  LQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKL 1053

Query: 285  ----------------KAEGLEKSLSSLETRRAGEAKEL----AEAQREAELLRKQLSKT 324
                            K E   + L  L+ R  GE+ EL     E Q+ AE LR QL + 
Sbjct: 1054 RLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRK 1113

Query: 325  QEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQ 384
            +E+L+A +   E+      + + S   +Q        L E  + L+ +R        + +
Sbjct: 1114 EEELQAALARAEDEGGARAQLLKSLREAQA------ALAEAQEDLESER--------VAR 1159

Query: 385  VRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEH 444
             + +     L  + E L  +++  D+L+   T   Q L ++  ++V  L   L+ +   H
Sbjct: 1160 TKAEKQRRDLGEELEALRGELE--DTLDS--TNAQQELRSKREQEVTELKKTLEEETRIH 1215

Query: 445  SDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDK---AAEVEVERMGAKGLQLELSRAQ 501
              +V++L+ +      ++  Q  EQA   +   +K   A E EV       L+ ELS  Q
Sbjct: 1216 EAAVQELRQRHGQALGELAEQ-LEQARRGKGAWEKTRLALEAEVSE-----LRAELSSLQ 1269

Query: 502  EARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVH 561
             AR+  +Q+    E QL+ V       +        K++ A A+L +++  L+ A  K  
Sbjct: 1270 TARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESK-- 1327

Query: 562  TIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGR 621
            TIR  ++++L+  + +               + Q+L +E  R    L    R ++ E   
Sbjct: 1328 TIR--LSKELSSTEAQLH-------------DAQELLQEETRAKLALGSRVRAMEAEAAG 1372

Query: 622  AREQGEAE---RQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQE 678
             REQ E E   R++  +  Q  + +L + +         LE   + ++ +  EA +L Q 
Sbjct: 1373 LREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQR 1432

Query: 679  LTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQ--E 736
            L ++ E       +++     RL+++L D    L + R    + V +L + QR+  Q   
Sbjct: 1433 LAEKTETV-----DRLERGRRRLQQELDDATMDLEQQR----QLVSTLEKKQRKFDQLLA 1483

Query: 737  KERSQELRRLQEEARKE-EGQRLARRLQELERDKNLMLATLQQEGLLSRYKQQRLLTV-L 794
            +E++  LR ++E  R E EG+    R   L R         +QE      +Q R L   L
Sbjct: 1484 EEKAAVLRAVEERERAEAEGREREARALSLTR-----ALEEEQEAREELERQNRALRAEL 1538

Query: 795  PSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGSLSVLLDDLQDLSEAISKEEAVC 854
             +LL  K  V  S    E +      AA      ++  ++ L D+L    +A  + E   
Sbjct: 1539 EALLSSKDDVGKSVHELERACRVAEQAA----NDLRAQVTELEDELTAAEDAKLRLEVTV 1594

Query: 855  Q 855
            Q
Sbjct: 1595 Q 1595



 Score = 97.4 bits (241), Expect = 5e-20
 Identities = 160/684 (23%), Positives = 280/684 (40%), Gaps = 101/684 (14%)

Query: 190  LRRLEEE----VRLLRETSLQQKMRLEAQA-MELEALAR--AEKAGR---AEAEGLRAAL 239
            L R E+E     +LL+     Q    EAQ  +E E +AR  AEK  R    E E LR  L
Sbjct: 1121 LARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGEL 1180

Query: 240  --------AGAEVVRKNLEEGSQ--RELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGL 289
                    A  E+  K  +E ++  + LEE  R+H+  +  L Q H +AL  L  + E  
Sbjct: 1181 EDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQA 1240

Query: 290  EKSLSSLE-TRRAGEAK---------ELAEAQREAELLRKQLSKTQEDLEAQVTLVENLR 339
             +   + E TR A EA+          L  A++E E  R++L    ++++ +    E  R
Sbjct: 1241 RRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERAR 1300

Query: 340  KYVGEQV---PSEVHSQTWELE--RQKLLETMQHLQEDRDSLHATAELLQ---------- 384
                E++    +E+ + +  L     K +   + L      LH   ELLQ          
Sbjct: 1301 AEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALG 1360

Query: 385  VRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEH 444
             RV+++    A   E+L  +    +    E  +  Q+ L+ WR +       L+A E   
Sbjct: 1361 SRVRAMEAEAAGLREQLEEEAAARERAGREL-QTAQAQLSEWRRRQEEEAGALEAGEEAR 1419

Query: 445  SDSVKQLKGQVASLQEK---VTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLE----- 496
              + ++ +     L EK   V    + +  LQ+ L D   ++E +R     L+ +     
Sbjct: 1420 RRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFD 1479

Query: 497  ---------LSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLP 547
                     + RA E R R + +    E +   +  A+   Q   E    +     A+L 
Sbjct: 1480 QLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELE 1539

Query: 548  SLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAE 607
            +L +      + VH +      + A     Q +  L   VT++  EL    + + RL+  
Sbjct: 1540 ALLSSKDDVGKSVHEL------ERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVT 1593

Query: 608  LQLSARLIQQEVGRAREQGEAERQQLSKVAQ--QLEQELQQTQESLA------------S 653
            +Q      ++++    E GE  R+QL+K  +  ++E++ ++ Q +LA             
Sbjct: 1594 VQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEE 1653

Query: 654  LGLQLEVARQGQQESTEEAASLRQEL-----------TQQQELYGQALQE----KVAEVE 698
            L  Q+  A QG++E+ ++   ++ ++           T ++E++ Q  +     K  E E
Sbjct: 1654 LKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAE 1713

Query: 699  T-RLREQL--SDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEG 755
              RL+E+L  SD  RR  +  R+     V+   + + A  E++R  E R  Q E   EE 
Sbjct: 1714 VLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEE 1773

Query: 756  QRLARRLQELERDKNLMLATLQQE 779
            Q  +  L +  R   L + +L  E
Sbjct: 1774 QSNSELLNDRYRKLLLQVESLTTE 1797



 Score = 93.6 bits (231), Expect = 7e-19
 Identities = 176/707 (24%), Positives = 293/707 (41%), Gaps = 117/707 (16%)

Query: 156  SDRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQA 215
            +++ E  RRG+  G      L+ +AEV      ELR     ++  R+   Q++ RLE Q 
Sbjct: 1234 AEQLEQARRGK--GAWEKTRLALEAEV-----SELRAELSSLQTARQEGEQRRRRLELQL 1286

Query: 216  MELEALARAEKAGRAE-AEGLRAALAGAEVVRKNLEEGS------QRELEEVQ-RLHQEQ 267
             E++  A   +  RAE AE L+ A A  E V   L E         +EL   + +LH  Q
Sbjct: 1287 QEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQ 1346

Query: 268  LSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQREAELLRKQLS---KT 324
               L Q    A  +L S+   +E   + L  +   EA     A RE +  + QLS   + 
Sbjct: 1347 --ELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRR 1404

Query: 325  QEDLEAQVTLVENLRKYVGEQ------------------------VPSEVHSQTWELERQ 360
            QE+    +   E  R+    +                        +  E+   T +LE+Q
Sbjct: 1405 QEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQ 1464

Query: 361  K-LLETMQHLQEDRDSLHA---TAELLQVRVQSLTHILALQEE----ELTRKVQPSDSLE 412
            + L+ T++  Q   D L A    A L  V  +        + E     LTR ++      
Sbjct: 1465 RQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAR 1524

Query: 413  PEFTRKCQSLLNRWREKVFALM-----VQLKAQELEHS-----DSVKQLKGQVASLQEKV 462
             E  R+ ++L    R ++ AL+     V     ELE +      +   L+ QV  L++++
Sbjct: 1525 EELERQNRAL----RAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDEL 1580

Query: 463  TSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAE------- 515
            T  + E A L+  +  +A + + ER     LQ      +E RR+  +Q   AE       
Sbjct: 1581 T--AAEDAKLRLEVTVQALKTQHER----DLQGRDEAGEERRRQLAKQLRDAEVERDEER 1634

Query: 516  EQLRLVVNAVSSSQIWLETTMAKV-------EGAAAQLPSLNNRLSYAVRKVHTIRGLIA 568
            +Q  L V A    +  LE   A++       E A  QL  +  ++    R+V   R   +
Sbjct: 1635 KQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETR--TS 1692

Query: 569  RKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEA 628
            R+   +Q R+    L     +V L LQ+     +R   + Q     +  EV        A
Sbjct: 1693 REEIFSQNRESEKRLKGLEAEV-LRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAA 1751

Query: 629  ---ERQQLSKVAQQLEQELQQTQESLASLG-------LQLE---VARQGQQESTEEAASL 675
               E++QL     QLE+EL++ Q +   L        LQ+E        ++  + +A S 
Sbjct: 1752 ILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESG 1811

Query: 676  RQELTQQ-QELYGQALQEKVAEVETR-------LREQLSDTERRLNEARREHAKAVVSLR 727
            RQ+L +Q QEL G+ L E+ A    R       L  +L+  E +L +  RE   +   +R
Sbjct: 1812 RQQLERQIQELRGR-LGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVR 1870

Query: 728  QIQRRAAQEKERSQELRRLQEEARK--EEG----QRLARRLQELERD 768
            + ++R  +   + +E RR+ ++ R   E+G    ++L R+L+E E +
Sbjct: 1871 RAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEE 1917



 Score = 90.9 bits (224), Expect = 5e-18
 Identities = 145/582 (24%), Positives = 246/582 (42%), Gaps = 63/582 (10%)

Query: 293  LSSLETRRAGEAKELA---EAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSE 349
            L+ LE  R  +  ++    +A     L R+   K Q+   A   +  N   Y+  +    
Sbjct: 800  LAQLEEERDLKVTDIIVSFQAAARGYLARRAFQKRQQQQSALRVMQRNCAAYLKLR---- 855

Query: 350  VHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEE------ELTR 403
             H Q W L   K+   +Q  ++D        E+LQ R Q L  +  LQ++      EL  
Sbjct: 856  -HWQWWRLFT-KVKPLLQVTRQD--------EVLQARAQELQKVQELQQQSAREVGELQG 905

Query: 404  KVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQ----LKAQELEHSDSVKQLKGQVASLQ 459
            +V     LE E  R  + L  R   ++ A   +    L A++ E    V +L+ +V   +
Sbjct: 906  RVA---QLEEERARLAEQL--RAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEE 960

Query: 460  EKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLR 519
            E       E+  LQ+ +Q+  A +E E    + LQLE    +   +++++     E+Q  
Sbjct: 961  ECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQ-- 1018

Query: 520  LVVNAVSSSQIWLETTMAKVEGAAAQ----LPSLNN-RLSYAVRKVHTIRGLIARKLALA 574
               + +S  +  LE  +A+    AA+    + SLN  RL Y      TI  +  R     
Sbjct: 1019 --NSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEA----TIADMEDRLRKEE 1072

Query: 575  QLRQESCPLPPPVTDVSLELQ-QLREERNR---LDAELQLSARLIQQEVGRAREQGEAER 630
            + RQE   L   +   S ELQ Q+ E++ R   L A+L      +Q  + RA ++G A R
Sbjct: 1073 KGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGA-R 1131

Query: 631  QQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQAL 690
             QL K  ++ +  L + QE L S  +    A + +++  EE  +LR EL  +  L     
Sbjct: 1132 AQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGEL--EDTLDSTNA 1189

Query: 691  QEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEA 750
            Q+   E+ ++  +++++ ++ L E  R H  AV  LRQ   +A  E     E  R  + A
Sbjct: 1190 QQ---ELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGA 1246

Query: 751  RKEEGQRLARRLQELERDKNLMLATLQQEGLLSRYKQQRLLTVLPSLLDKKKSVVSSPRP 810
             ++    L   + EL  + +  L T +QEG   R +       L   L + +        
Sbjct: 1247 WEKTRLALEAEVSELRAELS-SLQTARQEGEQRRRR-------LELQLQEVQGRAGDGER 1298

Query: 811  PECSASAPVAAAVPTRESIKGSLSVLLDDLQDLSEAISKEEA 852
                A+  +  A    E++ G+L+        LS+ +S  EA
Sbjct: 1299 ARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEA 1340



 Score = 84.0 bits (206), Expect = 6e-16
 Identities = 130/592 (21%), Positives = 236/592 (39%), Gaps = 77/592 (13%)

Query: 138  RRLDTQRPQVTMWERDVSSDRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQE----LRRL 193
            R L T + Q++ W R     RQE        G E  +  +++AE + ++L E    + RL
Sbjct: 1389 RELQTAQAQLSEWRR-----RQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRL 1443

Query: 194  EEEVRLLRETSLQQKMRLEAQAMELEALARAE-KAGRAEAEGLRAALAGAEVVRKNLEEG 252
            E   R L++      M LE Q   +  L + + K  +  AE   A L   E   +   EG
Sbjct: 1444 ERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEG 1503

Query: 253  SQRE---------LEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGE 303
             +RE         LEE Q   +E+L    +A    L +L S  + + KS+  LE      
Sbjct: 1504 REREARALSLTRALEEEQEA-REELERQNRALRAELEALLSSKDDVGKSVHELE------ 1556

Query: 304  AKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHS-------QTWE 356
             +    A++ A  LR Q+++ +++L A       LR  V  Q     H        +  E
Sbjct: 1557 -RACRVAEQAANDLRAQVTELEDELTAAEDA--KLRLEVTVQALKTQHERDLQGRDEAGE 1613

Query: 357  LERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFT 416
              R++L + ++  + +RD       L     + L   L   + ++    Q  +    +  
Sbjct: 1614 ERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLR 1673

Query: 417  RKCQSLLNRWRE--KVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQR 474
            +    +   WRE  +      ++ +Q  E    +K L+ +V  LQE++ +  + +   Q+
Sbjct: 1674 KMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQ 1733

Query: 475  SLQDKAAEVEVERMGAKGL-----QLE--LSRAQEARRRWQQQTASAEEQLRLVVNAVSS 527
               + A EV    +    +     QLE  L + +E     Q  +    ++ R ++  V S
Sbjct: 1734 DRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVES 1793

Query: 528  SQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPV 587
                L T ++     +A+  S   +L    R++  +RG +  + A A+ R +       +
Sbjct: 1794 ----LTTELSAERSFSAKAESGRQQLE---RQIQELRGRLGEEDAGARARHKMT-----I 1841

Query: 588  TDVSLELQQLREERNRLDAELQLSARLIQQEVGRARE---QGEAERQ------------- 631
              +  +L Q  E+  +   E  LS +L+++   R +E   Q E ER+             
Sbjct: 1842 AALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGN 1901

Query: 632  ----QLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQEL 679
                QL +  ++ E+E  + Q     L  +LE   +  +    E  +LR  L
Sbjct: 1902 LRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRL 1953


>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
          Length = 1995

 Score =  106 bits (264), Expect = 1e-22
 Identities = 171/721 (23%), Positives = 298/721 (41%), Gaps = 105/721 (14%)

Query: 175  ALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEG 234
            A  Q+ E++V +L+     EEE     +T   +K RL+    ELEA   AE+  R +   
Sbjct: 932  ARKQELELVVSELEARVGEEEECSRQMQT---EKKRLQQHIQELEAHLEAEEGARQK--- 985

Query: 235  LRAALAGAEVVRKNLEEG------SQRELEEVQRLHQEQL---SSLTQAHEEALSSLTS- 284
            L+      E   K  EE          +L + ++L +++L   SS     EE + SL   
Sbjct: 986  LQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKL 1045

Query: 285  ----------------KAEGLEKSLSSLETRRAGEAKEL----AEAQREAELLRKQLSKT 324
                            K E   + L  L+ R  GE+ EL     E Q+ AE LR QL + 
Sbjct: 1046 RLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRK 1105

Query: 325  QEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQ 384
            +E+L+A +   E+      + + S   +Q        L E  + L+ +R        + +
Sbjct: 1106 EEELQAALARAEDEGGARAQLLKSLREAQA------ALAEAQEDLESER--------VAR 1151

Query: 385  VRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEH 444
             + +     L  + E L  +++  D+L+   T   Q L ++  ++V  L   L+ +   H
Sbjct: 1152 TKAEKQRRDLGEELEALRGELE--DTLDS--TNAQQELRSKREQEVTELKKTLEEETRIH 1207

Query: 445  SDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDK---AAEVEVERMGAKGLQLELSRAQ 501
              +V++L+ +      ++  Q  EQA   +   +K   A E EV       L+ ELS  Q
Sbjct: 1208 EAAVQELRQRHGQALGELAEQ-LEQARRGKGAWEKTRLALEAEVSE-----LRAELSSLQ 1261

Query: 502  EARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVH 561
             AR+  +Q+    E QL+ V       +        K++ A A+L +++  L+ A  K  
Sbjct: 1262 TARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESK-- 1319

Query: 562  TIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGR 621
            TIR  ++++L+  + +               + Q+L +E  R    L    R ++ E   
Sbjct: 1320 TIR--LSKELSSTEAQLH-------------DAQELLQEETRAKLALGSRVRAMEAEAAG 1364

Query: 622  AREQGEAE---RQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQE 678
             REQ E E   R++  +  Q  + +L + +         LE   + ++ +  EA +L Q 
Sbjct: 1365 LREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQR 1424

Query: 679  LTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQ--E 736
            L ++ E       +++     RL+++L D    L + R    + V +L + QR+  Q   
Sbjct: 1425 LAEKTETV-----DRLERGRRRLQQELDDATMDLEQQR----QLVSTLEKKQRKFDQLLA 1475

Query: 737  KERSQELRRLQEEARKE-EGQRLARRLQELERDKNLMLATLQQEGLLSRYKQQRLLTV-L 794
            +E++  LR ++E  R E EG+    R   L R         +QE      +Q R L   L
Sbjct: 1476 EEKAAVLRAVEERERAEAEGREREARALSLTR-----ALEEEQEAREELERQNRALRAEL 1530

Query: 795  PSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGSLSVLLDDLQDLSEAISKEEAVC 854
             +LL  K  V  S    E +      AA      ++  ++ L D+L    +A  + E   
Sbjct: 1531 EALLSSKDDVGKSVHELERACRVAEQAA----NDLRAQVTELEDELTAAEDAKLRLEVTV 1586

Query: 855  Q 855
            Q
Sbjct: 1587 Q 1587



 Score = 97.4 bits (241), Expect = 5e-20
 Identities = 160/684 (23%), Positives = 280/684 (40%), Gaps = 101/684 (14%)

Query: 190  LRRLEEE----VRLLRETSLQQKMRLEAQA-MELEALAR--AEKAGR---AEAEGLRAAL 239
            L R E+E     +LL+     Q    EAQ  +E E +AR  AEK  R    E E LR  L
Sbjct: 1113 LARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGEL 1172

Query: 240  --------AGAEVVRKNLEEGSQ--RELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGL 289
                    A  E+  K  +E ++  + LEE  R+H+  +  L Q H +AL  L  + E  
Sbjct: 1173 EDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQA 1232

Query: 290  EKSLSSLE-TRRAGEAK---------ELAEAQREAELLRKQLSKTQEDLEAQVTLVENLR 339
             +   + E TR A EA+          L  A++E E  R++L    ++++ +    E  R
Sbjct: 1233 RRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERAR 1292

Query: 340  KYVGEQV---PSEVHSQTWELE--RQKLLETMQHLQEDRDSLHATAELLQ---------- 384
                E++    +E+ + +  L     K +   + L      LH   ELLQ          
Sbjct: 1293 AEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALG 1352

Query: 385  VRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEH 444
             RV+++    A   E+L  +    +    E  +  Q+ L+ WR +       L+A E   
Sbjct: 1353 SRVRAMEAEAAGLREQLEEEAAARERAGREL-QTAQAQLSEWRRRQEEEAGALEAGEEAR 1411

Query: 445  SDSVKQLKGQVASLQEK---VTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLE----- 496
              + ++ +     L EK   V    + +  LQ+ L D   ++E +R     L+ +     
Sbjct: 1412 RRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFD 1471

Query: 497  ---------LSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLP 547
                     + RA E R R + +    E +   +  A+   Q   E    +     A+L 
Sbjct: 1472 QLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELE 1531

Query: 548  SLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAE 607
            +L +      + VH +      + A     Q +  L   VT++  EL    + + RL+  
Sbjct: 1532 ALLSSKDDVGKSVHEL------ERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVT 1585

Query: 608  LQLSARLIQQEVGRAREQGEAERQQLSKVAQ--QLEQELQQTQESLA------------S 653
            +Q      ++++    E GE  R+QL+K  +  ++E++ ++ Q +LA             
Sbjct: 1586 VQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEE 1645

Query: 654  LGLQLEVARQGQQESTEEAASLRQEL-----------TQQQELYGQALQE----KVAEVE 698
            L  Q+  A QG++E+ ++   ++ ++           T ++E++ Q  +     K  E E
Sbjct: 1646 LKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAE 1705

Query: 699  T-RLREQL--SDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEG 755
              RL+E+L  SD  RR  +  R+     V+   + + A  E++R  E R  Q E   EE 
Sbjct: 1706 VLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEE 1765

Query: 756  QRLARRLQELERDKNLMLATLQQE 779
            Q  +  L +  R   L + +L  E
Sbjct: 1766 QSNSELLNDRYRKLLLQVESLTTE 1789



 Score = 93.6 bits (231), Expect = 7e-19
 Identities = 176/707 (24%), Positives = 293/707 (41%), Gaps = 117/707 (16%)

Query: 156  SDRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQA 215
            +++ E  RRG+  G      L+ +AEV      ELR     ++  R+   Q++ RLE Q 
Sbjct: 1226 AEQLEQARRGK--GAWEKTRLALEAEV-----SELRAELSSLQTARQEGEQRRRRLELQL 1278

Query: 216  MELEALARAEKAGRAE-AEGLRAALAGAEVVRKNLEEGS------QRELEEVQ-RLHQEQ 267
             E++  A   +  RAE AE L+ A A  E V   L E         +EL   + +LH  Q
Sbjct: 1279 QEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQ 1338

Query: 268  LSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQREAELLRKQLS---KT 324
               L Q    A  +L S+   +E   + L  +   EA     A RE +  + QLS   + 
Sbjct: 1339 --ELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRR 1396

Query: 325  QEDLEAQVTLVENLRKYVGEQ------------------------VPSEVHSQTWELERQ 360
            QE+    +   E  R+    +                        +  E+   T +LE+Q
Sbjct: 1397 QEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQ 1456

Query: 361  K-LLETMQHLQEDRDSLHA---TAELLQVRVQSLTHILALQEE----ELTRKVQPSDSLE 412
            + L+ T++  Q   D L A    A L  V  +        + E     LTR ++      
Sbjct: 1457 RQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAR 1516

Query: 413  PEFTRKCQSLLNRWREKVFALM-----VQLKAQELEHS-----DSVKQLKGQVASLQEKV 462
             E  R+ ++L    R ++ AL+     V     ELE +      +   L+ QV  L++++
Sbjct: 1517 EELERQNRAL----RAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDEL 1572

Query: 463  TSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAE------- 515
            T  + E A L+  +  +A + + ER     LQ      +E RR+  +Q   AE       
Sbjct: 1573 T--AAEDAKLRLEVTVQALKTQHER----DLQGRDEAGEERRRQLAKQLRDAEVERDEER 1626

Query: 516  EQLRLVVNAVSSSQIWLETTMAKV-------EGAAAQLPSLNNRLSYAVRKVHTIRGLIA 568
            +Q  L V A    +  LE   A++       E A  QL  +  ++    R+V   R   +
Sbjct: 1627 KQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETR--TS 1684

Query: 569  RKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEA 628
            R+   +Q R+    L     +V L LQ+     +R   + Q     +  EV        A
Sbjct: 1685 REEIFSQNRESEKRLKGLEAEV-LRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAA 1743

Query: 629  ---ERQQLSKVAQQLEQELQQTQESLASLG-------LQLE---VARQGQQESTEEAASL 675
               E++QL     QLE+EL++ Q +   L        LQ+E        ++  + +A S 
Sbjct: 1744 ILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESG 1803

Query: 676  RQELTQQ-QELYGQALQEKVAEVETR-------LREQLSDTERRLNEARREHAKAVVSLR 727
            RQ+L +Q QEL G+ L E+ A    R       L  +L+  E +L +  RE   +   +R
Sbjct: 1804 RQQLERQIQELRGR-LGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVR 1862

Query: 728  QIQRRAAQEKERSQELRRLQEEARK--EEG----QRLARRLQELERD 768
            + ++R  +   + +E RR+ ++ R   E+G    ++L R+L+E E +
Sbjct: 1863 RAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEE 1909



 Score = 90.9 bits (224), Expect = 5e-18
 Identities = 145/582 (24%), Positives = 246/582 (42%), Gaps = 63/582 (10%)

Query: 293  LSSLETRRAGEAKELA---EAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSE 349
            L+ LE  R  +  ++    +A     L R+   K Q+   A   +  N   Y+  +    
Sbjct: 792  LAQLEEERDLKVTDIIVSFQAAARGYLARRAFQKRQQQQSALRVMQRNCAAYLKLR---- 847

Query: 350  VHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEE------ELTR 403
             H Q W L   K+   +Q  ++D        E+LQ R Q L  +  LQ++      EL  
Sbjct: 848  -HWQWWRLFT-KVKPLLQVTRQD--------EVLQARAQELQKVQELQQQSAREVGELQG 897

Query: 404  KVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQ----LKAQELEHSDSVKQLKGQVASLQ 459
            +V     LE E  R  + L  R   ++ A   +    L A++ E    V +L+ +V   +
Sbjct: 898  RVA---QLEEERARLAEQL--RAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEE 952

Query: 460  EKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLR 519
            E       E+  LQ+ +Q+  A +E E    + LQLE    +   +++++     E+Q  
Sbjct: 953  ECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQ-- 1010

Query: 520  LVVNAVSSSQIWLETTMAKVEGAAAQ----LPSLNN-RLSYAVRKVHTIRGLIARKLALA 574
               + +S  +  LE  +A+    AA+    + SLN  RL Y      TI  +  R     
Sbjct: 1011 --NSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEA----TIADMEDRLRKEE 1064

Query: 575  QLRQESCPLPPPVTDVSLELQ-QLREERNR---LDAELQLSARLIQQEVGRAREQGEAER 630
            + RQE   L   +   S ELQ Q+ E++ R   L A+L      +Q  + RA ++G A R
Sbjct: 1065 KGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGA-R 1123

Query: 631  QQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQAL 690
             QL K  ++ +  L + QE L S  +    A + +++  EE  +LR EL  +  L     
Sbjct: 1124 AQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGEL--EDTLDSTNA 1181

Query: 691  QEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEA 750
            Q+   E+ ++  +++++ ++ L E  R H  AV  LRQ   +A  E     E  R  + A
Sbjct: 1182 QQ---ELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGA 1238

Query: 751  RKEEGQRLARRLQELERDKNLMLATLQQEGLLSRYKQQRLLTVLPSLLDKKKSVVSSPRP 810
             ++    L   + EL  + +  L T +QEG   R +       L   L + +        
Sbjct: 1239 WEKTRLALEAEVSELRAELS-SLQTARQEGEQRRRR-------LELQLQEVQGRAGDGER 1290

Query: 811  PECSASAPVAAAVPTRESIKGSLSVLLDDLQDLSEAISKEEA 852
                A+  +  A    E++ G+L+        LS+ +S  EA
Sbjct: 1291 ARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEA 1332



 Score = 84.0 bits (206), Expect = 6e-16
 Identities = 130/592 (21%), Positives = 236/592 (39%), Gaps = 77/592 (13%)

Query: 138  RRLDTQRPQVTMWERDVSSDRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQE----LRRL 193
            R L T + Q++ W R     RQE        G E  +  +++AE + ++L E    + RL
Sbjct: 1381 RELQTAQAQLSEWRR-----RQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRL 1435

Query: 194  EEEVRLLRETSLQQKMRLEAQAMELEALARAE-KAGRAEAEGLRAALAGAEVVRKNLEEG 252
            E   R L++      M LE Q   +  L + + K  +  AE   A L   E   +   EG
Sbjct: 1436 ERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEG 1495

Query: 253  SQRE---------LEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGE 303
             +RE         LEE Q   +E+L    +A    L +L S  + + KS+  LE      
Sbjct: 1496 REREARALSLTRALEEEQEA-REELERQNRALRAELEALLSSKDDVGKSVHELE------ 1548

Query: 304  AKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHS-------QTWE 356
             +    A++ A  LR Q+++ +++L A       LR  V  Q     H        +  E
Sbjct: 1549 -RACRVAEQAANDLRAQVTELEDELTAAEDA--KLRLEVTVQALKTQHERDLQGRDEAGE 1605

Query: 357  LERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFT 416
              R++L + ++  + +RD       L     + L   L   + ++    Q  +    +  
Sbjct: 1606 ERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLR 1665

Query: 417  RKCQSLLNRWRE--KVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQR 474
            +    +   WRE  +      ++ +Q  E    +K L+ +V  LQE++ +  + +   Q+
Sbjct: 1666 KMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQ 1725

Query: 475  SLQDKAAEVEVERMGAKGL-----QLE--LSRAQEARRRWQQQTASAEEQLRLVVNAVSS 527
               + A EV    +    +     QLE  L + +E     Q  +    ++ R ++  V S
Sbjct: 1726 DRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVES 1785

Query: 528  SQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPV 587
                L T ++     +A+  S   +L    R++  +RG +  + A A+ R +       +
Sbjct: 1786 ----LTTELSAERSFSAKAESGRQQLE---RQIQELRGRLGEEDAGARARHKMT-----I 1833

Query: 588  TDVSLELQQLREERNRLDAELQLSARLIQQEVGRARE---QGEAERQ------------- 631
              +  +L Q  E+  +   E  LS +L+++   R +E   Q E ER+             
Sbjct: 1834 AALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGN 1893

Query: 632  ----QLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQEL 679
                QL +  ++ E+E  + Q     L  +LE   +  +    E  +LR  L
Sbjct: 1894 LRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRL 1945


>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
          Length = 2036

 Score =  106 bits (264), Expect = 1e-22
 Identities = 171/721 (23%), Positives = 298/721 (41%), Gaps = 105/721 (14%)

Query: 175  ALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEG 234
            A  Q+ E++V +L+     EEE     +T   +K RL+    ELEA   AE+  R +   
Sbjct: 973  ARKQELELVVSELEARVGEEEECSRQMQT---EKKRLQQHIQELEAHLEAEEGARQK--- 1026

Query: 235  LRAALAGAEVVRKNLEEG------SQRELEEVQRLHQEQL---SSLTQAHEEALSSLTS- 284
            L+      E   K  EE          +L + ++L +++L   SS     EE + SL   
Sbjct: 1027 LQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKL 1086

Query: 285  ----------------KAEGLEKSLSSLETRRAGEAKEL----AEAQREAELLRKQLSKT 324
                            K E   + L  L+ R  GE+ EL     E Q+ AE LR QL + 
Sbjct: 1087 RLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRK 1146

Query: 325  QEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQ 384
            +E+L+A +   E+      + + S   +Q        L E  + L+ +R        + +
Sbjct: 1147 EEELQAALARAEDEGGARAQLLKSLREAQA------ALAEAQEDLESER--------VAR 1192

Query: 385  VRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEH 444
             + +     L  + E L  +++  D+L+   T   Q L ++  ++V  L   L+ +   H
Sbjct: 1193 TKAEKQRRDLGEELEALRGELE--DTLDS--TNAQQELRSKREQEVTELKKTLEEETRIH 1248

Query: 445  SDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDK---AAEVEVERMGAKGLQLELSRAQ 501
              +V++L+ +      ++  Q  EQA   +   +K   A E EV       L+ ELS  Q
Sbjct: 1249 EAAVQELRQRHGQALGELAEQ-LEQARRGKGAWEKTRLALEAEVSE-----LRAELSSLQ 1302

Query: 502  EARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVH 561
             AR+  +Q+    E QL+ V       +        K++ A A+L +++  L+ A  K  
Sbjct: 1303 TARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESK-- 1360

Query: 562  TIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGR 621
            TIR  ++++L+  + +               + Q+L +E  R    L    R ++ E   
Sbjct: 1361 TIR--LSKELSSTEAQLH-------------DAQELLQEETRAKLALGSRVRAMEAEAAG 1405

Query: 622  AREQGEAE---RQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQE 678
             REQ E E   R++  +  Q  + +L + +         LE   + ++ +  EA +L Q 
Sbjct: 1406 LREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQR 1465

Query: 679  LTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQ--E 736
            L ++ E       +++     RL+++L D    L + R    + V +L + QR+  Q   
Sbjct: 1466 LAEKTETV-----DRLERGRRRLQQELDDATMDLEQQR----QLVSTLEKKQRKFDQLLA 1516

Query: 737  KERSQELRRLQEEARKE-EGQRLARRLQELERDKNLMLATLQQEGLLSRYKQQRLLTV-L 794
            +E++  LR ++E  R E EG+    R   L R         +QE      +Q R L   L
Sbjct: 1517 EEKAAVLRAVEERERAEAEGREREARALSLTR-----ALEEEQEAREELERQNRALRAEL 1571

Query: 795  PSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGSLSVLLDDLQDLSEAISKEEAVC 854
             +LL  K  V  S    E +      AA      ++  ++ L D+L    +A  + E   
Sbjct: 1572 EALLSSKDDVGKSVHELERACRVAEQAA----NDLRAQVTELEDELTAAEDAKLRLEVTV 1627

Query: 855  Q 855
            Q
Sbjct: 1628 Q 1628



 Score = 97.4 bits (241), Expect = 5e-20
 Identities = 160/684 (23%), Positives = 280/684 (40%), Gaps = 101/684 (14%)

Query: 190  LRRLEEE----VRLLRETSLQQKMRLEAQA-MELEALAR--AEKAGR---AEAEGLRAAL 239
            L R E+E     +LL+     Q    EAQ  +E E +AR  AEK  R    E E LR  L
Sbjct: 1154 LARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGEL 1213

Query: 240  --------AGAEVVRKNLEEGSQ--RELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGL 289
                    A  E+  K  +E ++  + LEE  R+H+  +  L Q H +AL  L  + E  
Sbjct: 1214 EDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQA 1273

Query: 290  EKSLSSLE-TRRAGEAK---------ELAEAQREAELLRKQLSKTQEDLEAQVTLVENLR 339
             +   + E TR A EA+          L  A++E E  R++L    ++++ +    E  R
Sbjct: 1274 RRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERAR 1333

Query: 340  KYVGEQV---PSEVHSQTWELE--RQKLLETMQHLQEDRDSLHATAELLQ---------- 384
                E++    +E+ + +  L     K +   + L      LH   ELLQ          
Sbjct: 1334 AEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALG 1393

Query: 385  VRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEH 444
             RV+++    A   E+L  +    +    E  +  Q+ L+ WR +       L+A E   
Sbjct: 1394 SRVRAMEAEAAGLREQLEEEAAARERAGREL-QTAQAQLSEWRRRQEEEAGALEAGEEAR 1452

Query: 445  SDSVKQLKGQVASLQEK---VTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLE----- 496
              + ++ +     L EK   V    + +  LQ+ L D   ++E +R     L+ +     
Sbjct: 1453 RRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFD 1512

Query: 497  ---------LSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLP 547
                     + RA E R R + +    E +   +  A+   Q   E    +     A+L 
Sbjct: 1513 QLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELE 1572

Query: 548  SLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAE 607
            +L +      + VH +      + A     Q +  L   VT++  EL    + + RL+  
Sbjct: 1573 ALLSSKDDVGKSVHEL------ERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVT 1626

Query: 608  LQLSARLIQQEVGRAREQGEAERQQLSKVAQ--QLEQELQQTQESLA------------S 653
            +Q      ++++    E GE  R+QL+K  +  ++E++ ++ Q +LA             
Sbjct: 1627 VQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEE 1686

Query: 654  LGLQLEVARQGQQESTEEAASLRQEL-----------TQQQELYGQALQE----KVAEVE 698
            L  Q+  A QG++E+ ++   ++ ++           T ++E++ Q  +     K  E E
Sbjct: 1687 LKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAE 1746

Query: 699  T-RLREQL--SDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEG 755
              RL+E+L  SD  RR  +  R+     V+   + + A  E++R  E R  Q E   EE 
Sbjct: 1747 VLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEE 1806

Query: 756  QRLARRLQELERDKNLMLATLQQE 779
            Q  +  L +  R   L + +L  E
Sbjct: 1807 QSNSELLNDRYRKLLLQVESLTTE 1830



 Score = 93.6 bits (231), Expect = 7e-19
 Identities = 176/707 (24%), Positives = 293/707 (41%), Gaps = 117/707 (16%)

Query: 156  SDRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQA 215
            +++ E  RRG+  G      L+ +AEV      ELR     ++  R+   Q++ RLE Q 
Sbjct: 1267 AEQLEQARRGK--GAWEKTRLALEAEV-----SELRAELSSLQTARQEGEQRRRRLELQL 1319

Query: 216  MELEALARAEKAGRAE-AEGLRAALAGAEVVRKNLEEGS------QRELEEVQ-RLHQEQ 267
             E++  A   +  RAE AE L+ A A  E V   L E         +EL   + +LH  Q
Sbjct: 1320 QEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQ 1379

Query: 268  LSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQREAELLRKQLS---KT 324
               L Q    A  +L S+   +E   + L  +   EA     A RE +  + QLS   + 
Sbjct: 1380 --ELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRR 1437

Query: 325  QEDLEAQVTLVENLRKYVGEQ------------------------VPSEVHSQTWELERQ 360
            QE+    +   E  R+    +                        +  E+   T +LE+Q
Sbjct: 1438 QEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQ 1497

Query: 361  K-LLETMQHLQEDRDSLHA---TAELLQVRVQSLTHILALQEE----ELTRKVQPSDSLE 412
            + L+ T++  Q   D L A    A L  V  +        + E     LTR ++      
Sbjct: 1498 RQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAR 1557

Query: 413  PEFTRKCQSLLNRWREKVFALM-----VQLKAQELEHS-----DSVKQLKGQVASLQEKV 462
             E  R+ ++L    R ++ AL+     V     ELE +      +   L+ QV  L++++
Sbjct: 1558 EELERQNRAL----RAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDEL 1613

Query: 463  TSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAE------- 515
            T  + E A L+  +  +A + + ER     LQ      +E RR+  +Q   AE       
Sbjct: 1614 T--AAEDAKLRLEVTVQALKTQHER----DLQGRDEAGEERRRQLAKQLRDAEVERDEER 1667

Query: 516  EQLRLVVNAVSSSQIWLETTMAKV-------EGAAAQLPSLNNRLSYAVRKVHTIRGLIA 568
            +Q  L V A    +  LE   A++       E A  QL  +  ++    R+V   R   +
Sbjct: 1668 KQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETR--TS 1725

Query: 569  RKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEA 628
            R+   +Q R+    L     +V L LQ+     +R   + Q     +  EV        A
Sbjct: 1726 REEIFSQNRESEKRLKGLEAEV-LRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAA 1784

Query: 629  ---ERQQLSKVAQQLEQELQQTQESLASLG-------LQLE---VARQGQQESTEEAASL 675
               E++QL     QLE+EL++ Q +   L        LQ+E        ++  + +A S 
Sbjct: 1785 ILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESG 1844

Query: 676  RQELTQQ-QELYGQALQEKVAEVETR-------LREQLSDTERRLNEARREHAKAVVSLR 727
            RQ+L +Q QEL G+ L E+ A    R       L  +L+  E +L +  RE   +   +R
Sbjct: 1845 RQQLERQIQELRGR-LGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVR 1903

Query: 728  QIQRRAAQEKERSQELRRLQEEARK--EEG----QRLARRLQELERD 768
            + ++R  +   + +E RR+ ++ R   E+G    ++L R+L+E E +
Sbjct: 1904 RAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEE 1950



 Score = 90.9 bits (224), Expect = 5e-18
 Identities = 145/582 (24%), Positives = 246/582 (42%), Gaps = 63/582 (10%)

Query: 293  LSSLETRRAGEAKELA---EAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSE 349
            L+ LE  R  +  ++    +A     L R+   K Q+   A   +  N   Y+  +    
Sbjct: 833  LAQLEEERDLKVTDIIVSFQAAARGYLARRAFQKRQQQQSALRVMQRNCAAYLKLR---- 888

Query: 350  VHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEE------ELTR 403
             H Q W L   K+   +Q  ++D        E+LQ R Q L  +  LQ++      EL  
Sbjct: 889  -HWQWWRLFT-KVKPLLQVTRQD--------EVLQARAQELQKVQELQQQSAREVGELQG 938

Query: 404  KVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQ----LKAQELEHSDSVKQLKGQVASLQ 459
            +V     LE E  R  + L  R   ++ A   +    L A++ E    V +L+ +V   +
Sbjct: 939  RVA---QLEEERARLAEQL--RAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEE 993

Query: 460  EKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLR 519
            E       E+  LQ+ +Q+  A +E E    + LQLE    +   +++++     E+Q  
Sbjct: 994  ECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQ-- 1051

Query: 520  LVVNAVSSSQIWLETTMAKVEGAAAQ----LPSLNN-RLSYAVRKVHTIRGLIARKLALA 574
               + +S  +  LE  +A+    AA+    + SLN  RL Y      TI  +  R     
Sbjct: 1052 --NSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEA----TIADMEDRLRKEE 1105

Query: 575  QLRQESCPLPPPVTDVSLELQ-QLREERNR---LDAELQLSARLIQQEVGRAREQGEAER 630
            + RQE   L   +   S ELQ Q+ E++ R   L A+L      +Q  + RA ++G A R
Sbjct: 1106 KGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGA-R 1164

Query: 631  QQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQAL 690
             QL K  ++ +  L + QE L S  +    A + +++  EE  +LR EL  +  L     
Sbjct: 1165 AQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGEL--EDTLDSTNA 1222

Query: 691  QEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEA 750
            Q+   E+ ++  +++++ ++ L E  R H  AV  LRQ   +A  E     E  R  + A
Sbjct: 1223 QQ---ELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGA 1279

Query: 751  RKEEGQRLARRLQELERDKNLMLATLQQEGLLSRYKQQRLLTVLPSLLDKKKSVVSSPRP 810
             ++    L   + EL  + +  L T +QEG   R +       L   L + +        
Sbjct: 1280 WEKTRLALEAEVSELRAELS-SLQTARQEGEQRRRR-------LELQLQEVQGRAGDGER 1331

Query: 811  PECSASAPVAAAVPTRESIKGSLSVLLDDLQDLSEAISKEEA 852
                A+  +  A    E++ G+L+        LS+ +S  EA
Sbjct: 1332 ARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEA 1373



 Score = 84.0 bits (206), Expect = 6e-16
 Identities = 130/592 (21%), Positives = 236/592 (39%), Gaps = 77/592 (13%)

Query: 138  RRLDTQRPQVTMWERDVSSDRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQE----LRRL 193
            R L T + Q++ W R     RQE        G E  +  +++AE + ++L E    + RL
Sbjct: 1422 RELQTAQAQLSEWRR-----RQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRL 1476

Query: 194  EEEVRLLRETSLQQKMRLEAQAMELEALARAE-KAGRAEAEGLRAALAGAEVVRKNLEEG 252
            E   R L++      M LE Q   +  L + + K  +  AE   A L   E   +   EG
Sbjct: 1477 ERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEG 1536

Query: 253  SQRE---------LEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGE 303
             +RE         LEE Q   +E+L    +A    L +L S  + + KS+  LE      
Sbjct: 1537 REREARALSLTRALEEEQEA-REELERQNRALRAELEALLSSKDDVGKSVHELE------ 1589

Query: 304  AKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHS-------QTWE 356
             +    A++ A  LR Q+++ +++L A       LR  V  Q     H        +  E
Sbjct: 1590 -RACRVAEQAANDLRAQVTELEDELTAAEDA--KLRLEVTVQALKTQHERDLQGRDEAGE 1646

Query: 357  LERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFT 416
              R++L + ++  + +RD       L     + L   L   + ++    Q  +    +  
Sbjct: 1647 ERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLR 1706

Query: 417  RKCQSLLNRWRE--KVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQR 474
            +    +   WRE  +      ++ +Q  E    +K L+ +V  LQE++ +  + +   Q+
Sbjct: 1707 KMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQ 1766

Query: 475  SLQDKAAEVEVERMGAKGL-----QLE--LSRAQEARRRWQQQTASAEEQLRLVVNAVSS 527
               + A EV    +    +     QLE  L + +E     Q  +    ++ R ++  V S
Sbjct: 1767 DRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVES 1826

Query: 528  SQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPV 587
                L T ++     +A+  S   +L    R++  +RG +  + A A+ R +       +
Sbjct: 1827 ----LTTELSAERSFSAKAESGRQQLE---RQIQELRGRLGEEDAGARARHKMT-----I 1874

Query: 588  TDVSLELQQLREERNRLDAELQLSARLIQQEVGRARE---QGEAERQ------------- 631
              +  +L Q  E+  +   E  LS +L+++   R +E   Q E ER+             
Sbjct: 1875 AALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGN 1934

Query: 632  ----QLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQEL 679
                QL +  ++ E+E  + Q     L  +LE   +  +    E  +LR  L
Sbjct: 1935 LRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRL 1986


>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
          Length = 2115

 Score =  105 bits (261), Expect = 2e-22
 Identities = 176/687 (25%), Positives = 290/687 (42%), Gaps = 106/687 (15%)

Query: 174  QALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAE 233
            Q L++   +   Q++EL  L + V+ L+E  L +K +  A        A++E AGR E  
Sbjct: 1064 QELAKLRGLEAAQIKELEELRQTVKQLKE-QLAKKEKEHASGSG----AQSEAAGRTEPT 1118

Query: 234  GLRAALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSL 293
            G +     AEV +  LE+  Q++        QEQ  SL ++ E   +S   +   LE   
Sbjct: 1119 GPKLEALRAEVSK--LEQQCQKQ--------QEQADSLERSLEAERASRAERDSALETLQ 1168

Query: 294  SSLETR--RAGEAKE-LAEAQREAELLRKQL---SKTQEDLEAQV-----------TLVE 336
              LE +    G ++  LA AQRE    R ++   SK +++ +AQV           +L+ 
Sbjct: 1169 GQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLIS 1228

Query: 337  NLRKYVG--EQVPSEVHSQTWELER---------QKLLETMQHLQEDRDSLHATA----E 381
            +L + V    +   E   ++ EL+R         QKL E ++ LQ +  S  A A     
Sbjct: 1229 SLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSS 1288

Query: 382  LLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSL------LNRWREKVFALMV 435
             L+  VQSL        EE  ++   S++L  E T + +        L  W+EK F    
Sbjct: 1289 ALREEVQSL-------REEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQ 1341

Query: 436  QLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQL 495
             L   +LEH+ S + L  ++   +        EQA  ++  ++   E+E  +  A GL+ 
Sbjct: 1342 ALSTLQLEHT-STQALVSELLPAKHLCQQLQAEQAAAEKRHRE---ELEQSKQAAGGLRA 1397

Query: 496  ELSRAQ--------------EARRRWQQ---QTASAEEQLRLVVNAVSSSQIWLETTMAK 538
            EL RAQ              E  R  QQ   + AS  EQL ++  A     +  E     
Sbjct: 1398 ELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHG---LLAEENRGL 1454

Query: 539  VEGAAAQLPSLNNRLSYA----VRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLEL 594
             E A      L   L  A    V+++  +R     +LA  Q   +S      V     E 
Sbjct: 1455 GERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEG 1514

Query: 595  QQLR--EERNRLDAELQ-LSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESL 651
             +++  EER R   E Q L+A++ Q EV +  +  + E  +LSK     +Q  +  Q+ L
Sbjct: 1515 AKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVE--ELSKKLADSDQASKVQQQKL 1572

Query: 652  ASLGLQLEVARQGQQESTEEAASLRQELTQQQ---ELYGQALQEKVAEVETR------LR 702
             ++  Q   ++Q  Q    +   L+ +L+Q++   E Y   +++     + +      L+
Sbjct: 1573 KAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQ 1632

Query: 703  EQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRL 762
            EQL   E+   E +   A+A     ++Q+   + KE  Q  R L  + R  E Q +A   
Sbjct: 1633 EQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQ-VAHAD 1691

Query: 763  QELERDKNLMLATLQQEGLLSRYKQQR 789
            Q+L       +AT   + L SR  Q +
Sbjct: 1692 QQLRDLGKFQVAT---DALKSREPQAK 1715



 Score =  104 bits (259), Expect = 4e-22
 Identities = 181/809 (22%), Positives = 336/809 (41%), Gaps = 121/809 (14%)

Query: 157  DRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAM 216
            ++Q    +  S  L+  + L ++ E++  +L +L   EE +  L++   Q+K  +    +
Sbjct: 357  EKQAQLEKELSAALQDKKCLEEKNEILQGKLSQL---EEHLSQLQDNPPQEKGEVLGDVL 413

Query: 217  ELEALARAEKAGRAEAEGLRAALAGAEVVR-----KNLEEGSQRELEEVQRLH------Q 265
            +LE L +      A    L+A +   E  R     K L E    E EE Q+L       Q
Sbjct: 414  QLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFE-EEKQQLSSLITDLQ 472

Query: 266  EQLSSLTQAHEEALSS-------LTSKAEGLEKSLSSLETRRAGEAKELAEAQREAELLR 318
              +S+L+QA EE   +       LT++   L   L++L      + +ELA  +++A+  +
Sbjct: 473  SSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQ 532

Query: 319  KQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELER--QKLLETMQ-HLQEDRDS 375
             QL++T   L+ Q    + LR  V EQ+ S +  +  +L+   +K   T Q H Q+   +
Sbjct: 533  AQLAQT---LQQQEQASQGLRHQV-EQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATA 588

Query: 376  LHATAELLQVRVQSLTHILALQEEE------LTRKVQPS----DSLEPEFTR--KCQSLL 423
                   L+ R  +L  + AL++E+      L +++Q +    DS +   T+  + ++ L
Sbjct: 589  AEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAEL 648

Query: 424  NRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQ---SQEQAILQRSLQDKA 480
            +R  E++ A +   + ++ E    V +L+ Q+ S Q+K T +   +QE+  LQ  LQ   
Sbjct: 649  SRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALK 708

Query: 481  AEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVE 540
              ++V +     L+ E  RA +A    Q+  +  + + R +V      +  LE   A  +
Sbjct: 709  ESLKVTK---GSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRK 765

Query: 541  GAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCP-LPPPVTDVSLELQQLRE 599
            G  A+L  L         +   +R  +A  +A     +  C  L   V       +  ++
Sbjct: 766  GLEARLQQLGEAHQ---AETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQ 822

Query: 600  ERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLE 659
            E  +  A  Q     +++E  +AR++ +  +++++ +    E ++ + Q  LA L   L 
Sbjct: 823  EEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLA 882

Query: 660  VARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREH 719
             A Q  QE    A  L  +L+  QE    A  ++VA +ET +R+     E    E  +E 
Sbjct: 883  RALQQVQEKEVRAQKLADDLSTLQEKMA-ATSKEVARLETLVRKAGEQQETASRELVKEP 941

Query: 720  AKA-------------------VVSLRQIQRRAAQEKERSQELRRL-------QEEARKE 753
            A+A                     +L+ ++R A Q     + LR         Q+E R +
Sbjct: 942  ARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQ 1001

Query: 754  EGQRLAR------------------------RLQELERDKNLMLATLQQ---------EG 780
            + + +AR                        RLQ    ++ +  ATLQ+         EG
Sbjct: 1002 QEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEG 1061

Query: 781  L---LSRYK-----QQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGS 832
                L++ +     Q + L  L   + + K  ++       S S   + A    E     
Sbjct: 1062 KDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPK 1121

Query: 833  LSVLLDDLQDLSEAISKEEAVCQGDNLDR 861
            L  L  ++  L +   K++   Q D+L+R
Sbjct: 1122 LEALRAEVSKLEQQCQKQQE--QADSLER 1148



 Score =  100 bits (248), Expect = 8e-21
 Identities = 170/743 (22%), Positives = 306/743 (41%), Gaps = 99/743 (13%)

Query: 106  QARPLSTLPRMAPTWLSDIPLVQPPGHQDVSERRLDT-QRPQVTMWERDVSSDRQEPGRR 164
            Q   LS+  +     L ++   Q    QD +++     +  + ++ ERD +  + E   +
Sbjct: 552  QVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEK 611

Query: 165  GRSWGLEGSQALSQ-------QAEVIVRQLQ----ELRRLEEEVRLLRETSLQQKMRLEA 213
             ++  LE  Q   Q        A+  V Q Q    EL R  EE++   ET+ Q++   +A
Sbjct: 612  EKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQA 671

Query: 214  QAMELEALARAEKAGRAE-----------AEGLRAALAGAEVVRKNLEEGSQR---ELEE 259
            Q  ELE   R+E+    E            E L+A     +V + +LEE  +R    LEE
Sbjct: 672  QVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEE 731

Query: 260  VQRLHQE---QLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAEA-QREAE 315
             QR   E   +  SL + H+     L  +  G +     LE R     ++L EA Q E E
Sbjct: 732  QQRCISELKAETRSLVEQHKRERKELEEERAGRK----GLEAR----LQQLGEAHQAETE 783

Query: 316  LLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELE------------RQKLL 363
            +LR++L++         +  E L K V         SQ  E +            +++  
Sbjct: 784  VLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECE 843

Query: 364  ETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLL 423
            +  Q LQE ++ +       ++++    + LA     L R +Q     E    +K    L
Sbjct: 844  KARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVR-AQKLADDL 902

Query: 424  NRWREKVFALMVQL--------KAQELEHSDSVKQLK--GQVASLQEKVTSQSQEQAILQ 473
            +  +EK+ A   ++        KA E + + S + +K   +    Q +   + Q +    
Sbjct: 903  STLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCS 962

Query: 474  RSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLE 533
                 +A E E E+MG    +LE  RA     + QQQ    +++  +        +   +
Sbjct: 963  TQAALQAMEREAEQMGN---ELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQAD 1019

Query: 534  TTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLA--------LAQLRQESCPLPP 585
              + K   A  ++  L N L+    +  T++  +A  L         LA+LR        
Sbjct: 1020 LALEKAARAELEM-RLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIK 1078

Query: 586  PVTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQG---EAERQQLSKVAQQLEQ 642
             + ++   ++QL+E+  + + E    +    +  GR    G   EA R ++SK    LEQ
Sbjct: 1079 ELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSK----LEQ 1134

Query: 643  ELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQ------ALQEKVAE 696
            + Q+ QE   SL   LE  R  + E      +L+ +L ++ +  G       + Q ++A 
Sbjct: 1135 QCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAA 1194

Query: 697  VETRLR-------EQLSDTERRLNEARREHAKAVVSLRQ----IQRRAAQEKERSQELRR 745
              T+++       E  +   R   EA R+++  + SL +    + R+  +++  S+EL+R
Sbjct: 1195 FRTKVQDHSKAEDEWKAQVARGRQEAERKNS-LISSLEEEVSILNRQVLEKEGESKELKR 1253

Query: 746  LQEEARKEEGQRLARRLQELERD 768
            L   A  E+ Q+L  RL+ L+ +
Sbjct: 1254 L-VMAESEKSQKLEERLRLLQAE 1275



 Score = 99.4 bits (246), Expect = 1e-20
 Identities = 171/682 (25%), Positives = 282/682 (41%), Gaps = 136/682 (19%)

Query: 174  QALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAE 233
            QA+ ++AE +  +L+ LR        L E+  QQ+     Q  E+  L   ++ GRA+A+
Sbjct: 968  QAMEREAEQMGNELERLRAA------LMESQGQQQEERGQQEREVARLT--QERGRAQAD 1019

Query: 234  GLRAALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSL 293
                 LA  +  R  LE   Q  L E QR+    L       +EAL+   ++ EG ++ L
Sbjct: 1020 -----LALEKAARAELEMRLQNALNE-QRVEFATL-------QEALAHALTEKEGKDQEL 1066

Query: 294  SSLETRRAGEAKELAEAQREAELLRKQLSKTQED------------------------LE 329
            + L    A + KEL E ++  + L++QL+K +++                        L 
Sbjct: 1067 AKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALR 1126

Query: 330  AQVTLVENLRKYVGEQVPSEVHSQTWE----LERQKLLETMQ-HLQEDRDSL-------- 376
            A+V+ +E   +   EQ  S   S   E     ER   LET+Q  L+E    L        
Sbjct: 1127 AEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALA 1186

Query: 377  HATAELLQVRVQSLTHILALQE---------EELTRKVQPSDSLEPEFTRKCQSLLNRWR 427
             A  EL   R +   H  A  E         +E  RK     SLE E      S+LNR  
Sbjct: 1187 SAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEV-----SILNRQV 1241

Query: 428  EKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQS----QEQAILQRSLQDKAAEV 483
             +      +LK   +  S+  ++L+ ++  LQ +  S S    +  + L+  +Q    E 
Sbjct: 1242 LEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEA 1301

Query: 484  EVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAA 543
            E +R+ ++ L+ EL+   E      Q+  + +E+      A+S+ Q+   +T A V    
Sbjct: 1302 EKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALV---- 1357

Query: 544  AQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNR 603
                      S  +   H  + L A + A  +  +E             EL+Q ++    
Sbjct: 1358 ----------SELLPAKHLCQQLQAEQAAAEKRHRE-------------ELEQSKQAAGG 1394

Query: 604  LDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASL----GLQLE 659
            L AEL  + R + + +   ++  E ER      AQQL  E     E L+ L    GL  E
Sbjct: 1395 LRAELLRAQRELGELIPLRQKVAEQER-----TAQQLRAEKASYAEQLSMLKKAHGLLAE 1449

Query: 660  VARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREH 719
              R   + +      L  EL Q +E Y Q L    A+ ETRL            E +RE 
Sbjct: 1450 ENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRL-----------AEVQRE- 1497

Query: 720  AKAVVSLRQIQRRAAQEKERSQELRRLQEEAR-KEEGQRLARRLQELE---RDKNLMLAT 775
              A  + R+++   A  K    +++ L+E  R +EE Q+L  ++++LE   R++   +  
Sbjct: 1498 --AQSTARELEVMTA--KYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEE 1553

Query: 776  LQQE----GLLSRYKQQRLLTV 793
            L ++       S+ +QQ+L  V
Sbjct: 1554 LSKKLADSDQASKVQQQKLKAV 1575



 Score = 97.8 bits (242), Expect = 4e-20
 Identities = 165/732 (22%), Positives = 305/732 (41%), Gaps = 112/732 (15%)

Query: 135  VSERRLDTQRPQVTMWERDVSS-DRQEPGRRGRSWGLEG-SQALSQQAEVIVRQL----- 187
            +SE + +T R  V   +R+    + +  GR+G    L+   +A   + EV+ R+L     
Sbjct: 736  ISELKAET-RSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMA 794

Query: 188  ------QELRRLEEEVRLLRET---SLQQKMRLEAQAME-LEALARAEKAGRAEAEGLRA 237
                   E  +L +EV   RE    S Q++ +  A   E L  L    +  R E +  + 
Sbjct: 795  AQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKE 854

Query: 238  ALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEA---------LSSLTSKAEG 288
             +AG E    + E    R+  E+  LH     +L Q  E+          LS+L  K   
Sbjct: 855  KVAGIE---SHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAA 911

Query: 289  LEKSLSSLET--RRAGEAKELAEAQ----------REAELLRKQLSKTQEDLEAQVTLVE 336
              K ++ LET  R+AGE +E A  +          R+ E L +Q  +     +A +  +E
Sbjct: 912  TSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAME 971

Query: 337  NLRKYVGEQVPSEVHSQTWELERQKLLETMQHLQEDRDSLHA-TAELLQVRVQSLTHILA 395
               + +G ++         E  R  L+E+    QE+R       A L Q R ++    LA
Sbjct: 972  REAEQMGNEL---------ERLRAALMESQGQQQEERGQQEREVARLTQERGRAQAD-LA 1021

Query: 396  LQEE---ELTRKVQPS-DSLEPEFTRKCQSLLNRWREKVFA--LMVQLKAQELEHSDSVK 449
            L++    EL  ++Q + +    EF    ++L +   EK      + +L+  E      ++
Sbjct: 1022 LEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELE 1081

Query: 450  QLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQ 509
            +L+  V  L+E++  + +E A    +  + A   E      + L+ E+S+ ++  ++ Q+
Sbjct: 1082 ELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQE 1141

Query: 510  QTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIAR 569
            Q  S E  L     + +     LET   ++E  A +L    + L+ A R++   R  +  
Sbjct: 1142 QADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQD 1201

Query: 570  --------KLALAQLRQESCPLPPPVTDV-----------------SLELQQLREERNRL 604
                    K  +A+ RQE+      ++ +                 S EL++L    +  
Sbjct: 1202 HSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEK 1261

Query: 605  DAELQLSARLIQQEV----GRAREQGEAERQQLSKV----------AQQLEQELQQTQES 650
              +L+   RL+Q E      RA E+  A R+++  +          ++ L QEL    E 
Sbjct: 1262 SQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAER 1321

Query: 651  LASLGLQLEVARQGQQESTEEAASLRQELTQQQELYG---------QALQEKVAEVETRL 701
               LG +L+  ++   +  +  ++L+ E T  Q L           Q LQ + A  E R 
Sbjct: 1322 AEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRH 1381

Query: 702  REQLSDTERRLNEARREHAKAVVSLRQ---IQRRAAQEKERSQELRRLQEEARKEEGQRL 758
            RE+L  +++     R E  +A   L +   ++++ A+++  +Q+LR   E+A   E   +
Sbjct: 1382 REELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLR--AEKASYAEQLSM 1439

Query: 759  ARRLQELERDKN 770
             ++   L  ++N
Sbjct: 1440 LKKAHGLLAEEN 1451



 Score = 94.4 bits (233), Expect = 4e-19
 Identities = 159/674 (23%), Positives = 277/674 (41%), Gaps = 90/674 (13%)

Query: 185 RQLQELRRLEEEVRL-LRETSLQ-QKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGA 242
           ++L+ELR   E + + L ET  Q Q ++ E   M+ +    +E+ G              
Sbjct: 276 KELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENG-------------- 321

Query: 243 EVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLS-SLETRRA 301
                +L    +     +Q+L Q+ L+ LT+ H +A      K   LEK LS +L+ ++ 
Sbjct: 322 -----DLSFKLREFASHLQQL-QDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKC 375

Query: 302 GEAK-ELAE---AQREAELLRKQLSKTQE------DLEAQVTLVENLRKYVGEQVPSEVH 351
            E K E+ +   +Q E  L + Q +  QE      D+    TL +            +  
Sbjct: 376 LEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQAR 435

Query: 352 SQTWELER----QKLLETMQHLQEDRDSLHATAELLQVRVQSLTHI-------------- 393
            +  E ER     KLL    H +E++  L +    LQ  + +L+                
Sbjct: 436 VEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGAR 495

Query: 394 LALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQE-----LEH---- 444
           L  Q   LT ++   ++   +  ++   L  + +EK   L   L+ QE     L H    
Sbjct: 496 LTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQ 555

Query: 445 -SDSVKQLKGQVASLQEK-------------VTSQSQEQAILQRSLQDKAAEVEVERMGA 490
            S S+KQ + Q+  + EK               ++ +E ++ +R    K  E   +   A
Sbjct: 556 LSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAA 615

Query: 491 K--GLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPS 548
           K   LQ +L  A EAR   Q     A+ +   +   V   Q  +ET   +   A AQ+  
Sbjct: 616 KLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAE 675

Query: 549 LNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLR-----EERNR 603
           L  +L    +K  T +  +A++    Q + ++      VT  SLE ++ R     EE+ R
Sbjct: 676 LELQLRSEQQKA-TEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQR 734

Query: 604 LDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEVARQ 663
             +EL+   R + ++  R R++ E ER     +  +L+Q  +  Q     L  +L  A  
Sbjct: 735 CISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMA 794

Query: 664 GQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHAKAV 723
            Q  +  E   L +E+   +E Y  + QE+ A+     +EQL   +    +AR+E  +A 
Sbjct: 795 AQHTAESECEQLVKEVAAWRERYEDSQQEE-AQYGAMFQEQLMTLKEECEKARQELQEAK 853

Query: 724 VSLRQIQRRAAQEKERSQ-ELRRLQEEARK--EEGQRLARRLQELERDKNLMLATLQQEG 780
             +  I+  +  +  R Q EL  L     +  ++ Q    R Q+L  D    L+TLQ++ 
Sbjct: 854 EKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADD----LSTLQEKM 909

Query: 781 LLSRYKQQRLLTVL 794
             +  +  RL T++
Sbjct: 910 AATSKEVARLETLV 923



 Score = 80.5 bits (197), Expect = 6e-15
 Identities = 119/516 (23%), Positives = 227/516 (43%), Gaps = 64/516 (12%)

Query: 303 EAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKL 362
           E KEL E + + E L  +L +T +  +   T    + + +     +++  +  +L   KL
Sbjct: 274 EPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKI-----NQLSEENGDLSF-KL 327

Query: 363 LETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSL 422
            E   HLQ+ +D+L+   E      Q      A  E+EL+  +Q    LE +        
Sbjct: 328 REFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEK-------- 379

Query: 423 LNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRS---LQDK 479
                E +   + QL+    +  D+  Q KG+V     ++ +  QE A L  +   LQ +
Sbjct: 380 ----NEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQAR 435

Query: 480 AAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTM--- 536
              +E ER G +  +L   R      +  QQ +S    L+  ++ +S ++  LE      
Sbjct: 436 VEMLETER-GQQEAKLLAERGHFEEEK--QQLSSLITDLQSSISNLSQAKEELEQASQAH 492

Query: 537 -----AKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLA-----LAQLRQESCPLPPP 586
                A+V    ++L +LN  +    +++  ++     K A     L Q  Q S  L   
Sbjct: 493 GARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQ 552

Query: 587 VTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQ 646
           V  +S  L+Q  ++   +  + + + +   Q++  A E+ EA  ++     +QLE   ++
Sbjct: 553 VEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKE 612

Query: 647 TQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLS 706
               L  L  QL+VA + +  +     S+ Q   ++ EL  + ++E  A VET  +EQ  
Sbjct: 613 KAAKLEILQQQLQVANEARDSA---QTSVTQAQREKAEL-SRKVEELQACVETARQEQ-- 666

Query: 707 DTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEAR-------------KE 753
                 +EA+ + A+  + LR  Q++A +++  +QE  +LQE+ +             +E
Sbjct: 667 ------HEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEE 720

Query: 754 EGQRLARRLQELERDKNLMLATLQQEGLLSRYKQQR 789
           E +R A  L+E +R  + + A  +   L+ ++K++R
Sbjct: 721 EKRRAADALEEQQRCISELKA--ETRSLVEQHKRER 754



 Score = 77.4 bits (189), Expect = 5e-14
 Identities = 139/629 (22%), Positives = 262/629 (41%), Gaps = 86/629 (13%)

Query: 131  GHQDVSERRLDTQRPQVTMWERDVSSDRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQ-E 189
            G  + +  +L+  R +V+  E+     +++     RS  LE  +A   + +  +  LQ +
Sbjct: 1113 GRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERS--LEAERASRAERDSALETLQGQ 1170

Query: 190  LRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRKNL 249
            L    +E+   +      +  L A   +++  ++AE   +A+      A    E  RKN 
Sbjct: 1171 LEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQV-----ARGRQEAERKNS 1225

Query: 250  EEGSQRELEEVQRLHQEQLSSLTQAHE--EALSSLTSKAEGLEKSLSSLETRRAGEAKEL 307
               S  E  EV  L+++ L    ++ E    + + + K++ LE+ L  L+   A  +   
Sbjct: 1226 LISSLEE--EVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARA 1283

Query: 308  AEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVP-SEVHSQTWELERQKLLETM 366
            AE    +  LR+++   +E+ E Q    ENLR+ +  Q   +E   Q  +  ++K  +  
Sbjct: 1284 AE---RSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKE 1340

Query: 367  QHLQ----EDRDSLHATAELLQVR--VQSLTHILALQE----EELTRKVQPSDSLEPEFT 416
            Q L     E   +    +ELL  +   Q L    A  E    EEL +  Q +  L  E  
Sbjct: 1341 QALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELL 1400

Query: 417  RKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAIL---Q 473
            R  + L           ++ L+ +  E   + +QL+ + AS  E+++   +   +L    
Sbjct: 1401 RAQREL---------GELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEEN 1451

Query: 474  RSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTAS----AEEQLRLVVNAVSSSQ 529
            R L ++A       +G + L++EL +A+E   ++ Q+ A+    AE +L  V     S+ 
Sbjct: 1452 RGLGERA------NLGRQFLEVELDQARE---KYVQELAAVRADAETRLAEVQREAQSTA 1502

Query: 530  IWLETTMAKVEGAAAQLPSLNNR-------LSYAVRKVHTIRGLIARKLA-----LAQLR 577
              LE   AK EGA  ++     R       L+  V ++   +    +++      LA   
Sbjct: 1503 RELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSD 1562

Query: 578  QESCPLPPPVTDVSLELQQLREERNRLDAEL-QLSARLIQQE---------VGRAREQGE 627
            Q S      +  V  +  + ++E  RL A+L +L A+L Q+E         + +A+   +
Sbjct: 1563 QASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYD 1622

Query: 628  AERQQ-------------LSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAAS 674
            A++QQ             L K  ++L  E ++    L   GL+ + A Q  +  T +  S
Sbjct: 1623 AKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRS 1682

Query: 675  LRQELTQQQELYGQALQEKVAEVETRLRE 703
            L  ++    +      + +VA    + RE
Sbjct: 1683 LEAQVAHADQQLRDLGKFQVATDALKSRE 1711



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 130/522 (24%), Positives = 203/522 (38%), Gaps = 102/522 (19%)

Query: 174  QALSQQAEVIVRQLQELRRLEEEVRLLRET-SLQQKMRLEAQAMELEAL----------- 221
            Q L+ QAE      QEL+  +E+     +  S  Q      QA+  E L           
Sbjct: 1313 QELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQA 1372

Query: 222  --ARAEKAGRAEAEGLRAALAG--AEVVRKNLEEGS----QRELEEVQRLHQEQLSSLTQ 273
              A AEK  R E E  + A  G  AE++R   E G     ++++ E +R  Q QL +   
Sbjct: 1373 EQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQ-QLRAEKA 1431

Query: 274  AHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQREAELLRKQLSKTQE----DLE 329
            ++ E LS L  KA GL       E R  GE   L     E EL + +    QE      +
Sbjct: 1432 SYAEQLSML-KKAHGLLAE----ENRGLGERANLGRQFLEVELDQAREKYVQELAAVRAD 1486

Query: 330  AQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQS 389
            A+  L E  R+        EV +  +E  + K+LE  Q  QE+R  L A  E L+V  + 
Sbjct: 1487 AETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQRE 1546

Query: 390  LTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVK 449
             T     Q EEL++K+  SD       +K                  LKA + +  +S  
Sbjct: 1547 QTK----QVEELSKKLADSDQASKVQQQK------------------LKAVQAQGGES-- 1582

Query: 450  QLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQ 509
                             QE   LQ  L +  A++  +   A+  +L++ +A+      +Q
Sbjct: 1583 ----------------QQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQ 1626

Query: 510  QTASAEEQLRLVVNAVSSS---------------QIWLETTMAK--VEGAAAQLPSLNNR 552
            Q    +EQLR +      +               Q  L+T  A+       AQ+ SL  +
Sbjct: 1627 QNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQ 1686

Query: 553  LSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSA 612
            +++A ++   +R L   ++A   L+    P   P  D+S++   L  E       L +++
Sbjct: 1687 VAHADQQ---LRDLGKFQVATDALKSRE-PQAKPQLDLSIDSLDLSCEEG---TPLSITS 1739

Query: 613  RLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASL 654
            +L + +       GE         A  + Q L    ESL SL
Sbjct: 1740 KLPRTQPDGTSVPGEP--------ASPISQRLPPKVESLESL 1773


>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
            sapiens]
          Length = 1935

 Score =  104 bits (259), Expect = 4e-22
 Identities = 154/712 (21%), Positives = 296/712 (41%), Gaps = 107/712 (15%)

Query: 192  RLEEEVRLLRETSLQQKMR-LEAQAMELEALARAEKAGRAEAEGLRAALAGA-EVVRKNL 249
            R+E+E  L   + LQ+K++ L+A+  ELE    AE+  RA+ E LR+ L+   E + + L
Sbjct: 1093 RIEDEQAL--GSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERL 1150

Query: 250  EEGS--------------------QRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGL 289
            EE                      +R+LEE    H+   ++L + H ++++ L  + + L
Sbjct: 1151 EEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNL 1210

Query: 290  EKSLSSLETRRAGEAKELAEAQREAELLRK---QLSKTQEDLEAQV----TLVENLRKYV 342
            ++    LE  ++    EL +     E + K    L K    LE Q+    +  E  ++ V
Sbjct: 1211 QRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSV 1270

Query: 343  GEQVPSEVHSQT--WELERQ--------------KLLETMQ------HLQEDRDSLHATA 380
             +        QT   EL RQ              KL  T Q       L+E+  + +A A
Sbjct: 1271 NDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALA 1330

Query: 381  ELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQ 440
              LQ    S  H   L  E+   + +    L+   + K  S + +WR K     +Q + +
Sbjct: 1331 HALQ----SARHDCDLLREQYEEETEAKAELQRVLS-KANSEVAQWRTKYETDAIQ-RTE 1384

Query: 441  ELEHSDS-----VKQLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQL 495
            ELE +       +++ +  V ++  K +S  + +  LQ  ++D   +VE     A  L  
Sbjct: 1385 ELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDK 1444

Query: 496  ELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSY 555
            +     +    W+Q+                 SQ  LE++  +    + +L  L N    
Sbjct: 1445 KQRNFDKILAEWKQK--------------YEESQSELESSQKEARSLSTELFKLKNAYEE 1490

Query: 556  AVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAE-LQLSARL 614
            ++  + T       K     L++E   L   +      + +L + R +L+AE ++L + L
Sbjct: 1491 SLEHLETF------KRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSAL 1544

Query: 615  IQQEVGRAREQGEAERQQLS----------KVAQQLEQELQQTQESLASLGLQLEVARQG 664
             + E     E+G+  R QL           K+A++ ++E++Q + +   +   L+ +   
Sbjct: 1545 EEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEK-DEEMEQAKRNHLRVVDSLQTSLDA 1603

Query: 665  QQESTEEAASLRQELT---QQQELYGQALQEKVAEVETR---LREQLSDTERRLNEARRE 718
            +  S  EA  +++++     + E+         AE + +   L+  L DT+ +L++A R 
Sbjct: 1604 ETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRA 1663

Query: 719  HAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQ 778
            +     ++  ++RR    +   +ELR + E+   E  ++LA + + +E  + + L   Q 
Sbjct: 1664 NDDLKENIAIVERRNNLLQAELEELRAVVEQT--ERSRKLAEQ-ELIETSERVQLLHSQN 1720

Query: 779  EGLLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIK 830
              L+++ K  ++   L  L  + +  V   R  E  A   +  A    E +K
Sbjct: 1721 TSLINQKK--KMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELK 1770



 Score = 93.2 bits (230), Expect = 9e-19
 Identities = 156/766 (20%), Positives = 324/766 (42%), Gaps = 114/766 (14%)

Query: 171  EGSQALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRA 230
            E ++ L  + E+      + R+LE+E           +++ +   +EL  LA+ EK   A
Sbjct: 921  EMNERLEDEEEMNAELTAKKRKLEDEC---------SELKRDIDDLEL-TLAKVEKEKHA 970

Query: 231  ---EAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAE 287
               + + L   +AG + +   L     +E + +Q  HQ+ L  L QA E+ +++LT    
Sbjct: 971  TENKVKNLTEEMAGLDEIIAKL----TKEKKALQEAHQQALDDL-QAEEDKVNTLTKAKV 1025

Query: 288  GLEKSLSSLETRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVP 347
             LE+ +  LE     E K   + +R    L   L  TQE     +  +EN ++ + E++ 
Sbjct: 1026 KLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQE----SIMDLENDKQQLDERLK 1081

Query: 348  S---EVHSQTWELE---------RQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILA 395
                E+++    +E         ++KL E    ++E  + L A     + +V+ L   L+
Sbjct: 1082 KKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEA-ERTARAKVEKLRSDLS 1140

Query: 396  LQEEELTRKVQP---SDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQ----ELEHSDSV 448
             + EE++ +++    + S++ E  +K ++   + R  +    +Q +A       +H+DSV
Sbjct: 1141 RELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSV 1200

Query: 449  KQLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVE--------VERMGAKGLQLEL--- 497
             +L  Q+ +LQ       +E++  +  L D  + +E        +E+M  + L+ ++   
Sbjct: 1201 AELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKM-CRTLEDQMNEH 1259

Query: 498  -SRAQEARR--------RWQQQTASAE-----EQLRLVVNAVSSSQIWLETTMAKVEGAA 543
             S+A+E +R        R + QT + E     ++   +++ ++  ++     +  ++   
Sbjct: 1260 RSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQL 1319

Query: 544  AQLPSLNNRLSYAVRKVHTIRGLIARKL-----ALAQLRQESCPLPPPV--------TDV 590
             +     N L++A++       L+  +      A A+L++        V        TD 
Sbjct: 1320 EEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDA 1379

Query: 591  SLELQQLREERNRLDAELQ--------LSARLIQQEVGRAREQGEAER-----QQLSKVA 637
                ++L E + +L   LQ        ++A+    E  + R Q E E      ++ +  A
Sbjct: 1380 IQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAA 1439

Query: 638  QQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQ--EKVA 695
              L+++ +   + LA    + E ++   + S +EA SL  EL + +  Y ++L+  E   
Sbjct: 1440 AALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFK 1499

Query: 696  EVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEK-ERSQELRRLQEEARKEE 754
                 L+E++SD   +L  +     K +  L +++++   EK E    L   +     EE
Sbjct: 1500 RENKNLQEEISDLTEQLGSS----GKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEE 1555

Query: 755  GQRLARRLQ--ELERDKNLMLATLQQEGLLSRYKQQRLLTVLPSLLDK-----------K 801
            G+ L  +L+  +++ +    LA   +E   ++    R++  L + LD            K
Sbjct: 1556 GKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVK 1615

Query: 802  KSVVSSPRPPECSASAPVAAAVPTRESIKGSLSVLLDDLQDLSEAI 847
            K +       E   S     A   ++ +K   S+L D    L +A+
Sbjct: 1616 KKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAV 1661



 Score = 84.7 bits (208), Expect = 3e-16
 Identities = 115/555 (20%), Positives = 223/555 (40%), Gaps = 59/555 (10%)

Query: 288  GLEKSLSSLETRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGE--- 344
            GL   L  +   R        +AQ    L R +  K  E  ++ + +  N+R ++G    
Sbjct: 768  GLLGLLEEMRDERLSRIITRIQAQSRGVLARMEYKKLLERRDSLLVIQWNIRAFMGVKNW 827

Query: 345  -------QVPSEVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQ 397
                   ++   + S   E E   + E    L+E  +   A  + L+ ++ SL      +
Sbjct: 828  PWMKLYFKIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQ----E 883

Query: 398  EEELTRKVQPSDSLEPEFTRKCQSL-------------LNRWREKVFALMVQLKAQELEH 444
            + +L  +VQ       +   +C  L             +N   E    +  +L A++ + 
Sbjct: 884  KNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKL 943

Query: 445  SDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEAR 504
             D   +LK  +  L+  +    +E    + + ++K   +  E  G   +  +L++ ++A 
Sbjct: 944  EDECSELKRDIDDLELTLAKVEKE----KHATENKVKNLTEEMAGLDEIIAKLTKEKKAL 999

Query: 505  RRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIR 564
            +   QQ     +     VN ++ +++ LE  +  +EG+  Q   +   L  A RK+    
Sbjct: 1000 QEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLE--G 1057

Query: 565  GLIARKLALAQLRQESCPLPPPVTDVSLELQQLR---EERNRLDAELQLSARLIQQEVGR 621
             L   + ++  L  +   L   +     EL  L    E+   L ++LQ   + +Q  +  
Sbjct: 1058 DLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEE 1117

Query: 622  AREQGEAE---RQQLSKVAQQLEQELQQTQESLASLG----LQLEVARQGQQESTEEAAS 674
              E+ EAE   R ++ K+   L +EL++  E L   G    +Q+E+ ++ + E  +    
Sbjct: 1118 LEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRD 1177

Query: 675  LRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAA 734
            L +E T Q E    AL++K A+    L EQ+ + +R   +  +E ++  + L  +     
Sbjct: 1178 L-EEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNME 1236

Query: 735  QEKERSQELRRLQE--EARKEEGQRLARRLQELERDKNLMLATLQQE-GLLSRYKQQRLL 791
            Q  +    L ++    E +  E +  A   Q    D     A LQ E G LSR       
Sbjct: 1237 QIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQ------ 1290

Query: 792  TVLPSLLDKKKSVVS 806
                  LD+K++++S
Sbjct: 1291 ------LDEKEALIS 1299



 Score = 76.6 bits (187), Expect = 9e-14
 Identities = 132/644 (20%), Positives = 267/644 (41%), Gaps = 72/644 (11%)

Query: 176  LSQQAEVIVRQLQELRRLEEEVRL-LRETSLQQKMRLEAQAMELEALARAEK----AGRA 230
            L +Q + + R  Q+L + + E +L L + +   +  ++A+A  LE + R  +      R+
Sbjct: 1203 LGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKA-NLEKMCRTLEDQMNEHRS 1261

Query: 231  EAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLE 290
            +AE  + ++      R  L    Q E  E+ R   E+ + ++Q     L+  T + E L+
Sbjct: 1262 KAEETQRSVNDLTSQRAKL----QTENGELSRQLDEKEALISQLTRGKLT-YTQQLEDLK 1316

Query: 291  KSLSSLETRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGE------ 344
            + L      +   A  L  A+ + +LLR+Q    +E+ EA+  L   L K   E      
Sbjct: 1317 RQLEEEVKAKNALAHALQSARHDCDLLREQY---EEETEAKAELQRVLSKANSEVAQWRT 1373

Query: 345  QVPSEVHSQTWELE--RQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELT 402
            +  ++   +T ELE  ++KL + +Q  +E  ++++A    L+       H L  + E+L 
Sbjct: 1374 KYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLE----KTKHRLQNEIEDLM 1429

Query: 403  RKVQPSDSLEPEFTRKCQS---LLNRWREKVFALMVQLKAQELEH---SDSVKQLKGQVA 456
              V+ S++      +K ++   +L  W++K      +L++ + E    S  + +LK    
Sbjct: 1430 VDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYE 1489

Query: 457  SLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGL---QLELSRAQEARRRWQQQTAS 513
               E + +  +E   LQ  + D       E++G+ G    +LE  R Q    + + Q+A 
Sbjct: 1490 ESLEHLETFKRENKNLQEEISDLT-----EQLGSSGKTIHELEKVRKQLEAEKMELQSAL 1544

Query: 514  AEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRK-VHTIRGLIARKLA 572
             E +  L        +  LE    K E    +L   +  +  A R  +  +  L     A
Sbjct: 1545 EEAEASLEHEEGKILRAQLEFNQIKAE-IERKLAEKDEEMEQAKRNHLRVVDSLQTSLDA 1603

Query: 573  LAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQE-------------- 618
              + R E+  +   +     E++      NR+ AE Q   + +Q                
Sbjct: 1604 ETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRA 1663

Query: 619  ----------VGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQES 668
                      V R     +AE ++L  V +Q E+  +  ++ L     ++++        
Sbjct: 1664 NDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSL 1723

Query: 669  TEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQ 728
              +   +  +L+Q Q    +A+QE     E + ++ ++D      E ++E   +   L +
Sbjct: 1724 INQKKKMDADLSQLQTEVEEAVQE-CRNAEEKAKKAITDAAMMAEELKKEQDTSA-HLER 1781

Query: 729  IQRRAAQE----KERSQELRRLQEEARKEEGQRLARRLQELERD 768
            +++   Q     + R  E  ++  +  K++ Q+L  R++ELE +
Sbjct: 1782 MKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENE 1825



 Score = 74.7 bits (182), Expect = 3e-13
 Identities = 126/638 (19%), Positives = 253/638 (39%), Gaps = 86/638 (13%)

Query: 172  GSQALSQQAEVIVRQLQE-----------LRRLEEEVRLLRETSLQQKMRLEAQA----- 215
            G    +QQ E + RQL+E           L+    +  LLRE   Q +   EA+A     
Sbjct: 1304 GKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLRE---QYEEETEAKAELQRV 1360

Query: 216  --------------MELEALARAEKAGRAE---AEGLRAALAGAEVVR---KNLEEGSQR 255
                           E +A+ R E+   A+   A+ L+ A    E V     +LE+   R
Sbjct: 1361 LSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHR 1420

Query: 256  ELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQREAE 315
               E++ L  +      +    A ++L  K    +K L+  + +      EL  +Q+EA 
Sbjct: 1421 LQNEIEDLMVD-----VERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEAR 1475

Query: 316  LLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQHLQEDRDS 375
             L  +L K +   E  +  +E  ++   + +  E+   T +L      +T+  L++ R  
Sbjct: 1476 SLSTELFKLKNAYEESLEHLETFKRE-NKNLQEEISDLTEQLGSSG--KTIHELEKVRKQ 1532

Query: 376  LHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKC--------QSLLNRWR 427
            L A    LQ  ++     L  +E ++ R     + ++ E  RK         Q+  N  R
Sbjct: 1533 LEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLR 1592

Query: 428  EKVFALMVQLKAQELEHSDSVKQLKGQVASLQE---------KVTSQSQEQAILQRSLQD 478
              V +L   L A+    +++++  K     L E         ++ +++Q+Q    +SLQ 
Sbjct: 1593 V-VDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQV---KSLQS 1648

Query: 479  KAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAK 538
               + +++   A     +L        R      +  E+LR VV     S+   E  + +
Sbjct: 1649 LLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIE 1708

Query: 539  VEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKL--ALAQLRQESCPLPPPVTDVSLELQQ 596
                   L S N  L    +K+      +  ++  A+ + R         +TD ++  ++
Sbjct: 1709 TSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEE 1768

Query: 597  LREERN------RLDAELQLSARLIQQEVGRARE----QGEAERQQLSKVAQQLEQELQQ 646
            L++E++      R+   ++ + + +Q  +  A +     G+ + Q+L    ++LE EL+ 
Sbjct: 1769 LKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEA 1828

Query: 647  TQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYG------QALQEKVAEVETR 700
             Q+  A     +  + +  +E T +    R+ L + Q+L        +A + +  E E +
Sbjct: 1829 EQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQ 1888

Query: 701  LREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKE 738
                LS   +  +E      +A ++  Q+ +  A+ ++
Sbjct: 1889 ANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRD 1926



 Score = 50.8 bits (120), Expect = 5e-06
 Identities = 71/313 (22%), Positives = 131/313 (41%), Gaps = 39/313 (12%)

Query: 170  LEGSQALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAG- 228
            L  +  ++ +A+  V+ LQ L         L++T +Q    + A     E +A  E+   
Sbjct: 1629 LSHANRMAAEAQKQVKSLQSL---------LKDTQIQLDDAVRANDDLKENIAIVERRNN 1679

Query: 229  --RAEAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLHQE-------------QLSSLTQ 273
              +AE E LRA +   E  RK  E+      E VQ LH +              LS L  
Sbjct: 1680 LLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQT 1739

Query: 274  AHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVT 333
              EEA+    +  E  +K+++      A E K+  +     E ++K + +T +DL+ ++ 
Sbjct: 1740 EVEEAVQECRNAEEKAKKAITD-AAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLD 1798

Query: 334  LVENLRKYVGEQVPSEVHSQTWELERQKLLETMQHLQE---DRDSLHATAELLQVRVQSL 390
              E +    G++   ++ ++  ELE +   E  ++ +     R S     EL     +  
Sbjct: 1799 EAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDR 1858

Query: 391  THILALQE--EELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSV 448
             ++L LQ+  ++L  KV+       E   +  + L+++R+      VQ +  E E    +
Sbjct: 1859 KNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRK------VQHELDEAEERADI 1912

Query: 449  KQLKGQVASLQEK 461
             +   QV  L+ K
Sbjct: 1913 AE--SQVNKLRAK 1923



 Score = 39.3 bits (90), Expect = 0.016
 Identities = 50/215 (23%), Positives = 85/215 (39%), Gaps = 23/215 (10%)

Query: 641  EQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETR 700
            E+E+   +E    L   LE +   ++E  E+  SL QE    Q L  QA Q+ +A     
Sbjct: 846  EKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQ-LQVQAEQDNLA----- 899

Query: 701  LREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLAR 760
                  D E R ++  +   +    ++++  R   E+E + EL   ++   ++E   L R
Sbjct: 900  ------DAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAEL-TAKKRKLEDECSELKR 952

Query: 761  RLQELERDKNLMLATLQQEGLLSRYKQQRLLTVLPSL------LDKKKSVVSSPRPPECS 814
             + +LE    L LA +++E   +  K + L   +  L      L K+K  +         
Sbjct: 953  DIDDLE----LTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALD 1008

Query: 815  ASAPVAAAVPTRESIKGSLSVLLDDLQDLSEAISK 849
                    V T    K  L   +DDL+   E   K
Sbjct: 1009 DLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKK 1043


>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
          Length = 1417

 Score =  103 bits (258), Expect = 5e-22
 Identities = 151/743 (20%), Positives = 305/743 (41%), Gaps = 115/743 (15%)

Query: 152  RDVSSDRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQELRRLEEEVRLLRET------SL 205
            R +  +      + R   ++ S+ ++Q  E     L+    LE +  +LR+       + 
Sbjct: 424  RQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENKDEILRDKFSLMNENR 483

Query: 206  QQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLHQ 265
            + K+R+ AQ   L+   +  ++ R E   L   ++   + R+     S         L +
Sbjct: 484  ELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSY--------LSK 535

Query: 266  EQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQREAELLRKQLSKT- 324
             Q+SS +   +  +       E  +  +S L  + A   KE    +  A L   QLS++ 
Sbjct: 536  YQMSSFSNKEDRCIGC----CEANKLVISELRIKLA--IKEAEIQKLHANLTANQLSQSL 589

Query: 325  ------QEDLEAQVTLVENLRKYVGEQVPSEVHSQT-------WELERQKLLETMQHLQE 371
                  QE  +      E + K  G QV   V  Q        +E ERQ+L+  ++ L+ 
Sbjct: 590  ITCNDSQESSKLSSLETEPV-KLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRT 648

Query: 372  DRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLL---NRWRE 428
                + A    L+V +   T    L +EEL  K   S  LE E T+KC  LL    +  E
Sbjct: 649  KLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEE 708

Query: 429  KVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERM 488
            K+ A    + A+  E    + +   ++ SL+  + ++ ++  +      +KA ++ +E+ 
Sbjct: 709  KIVAYS-SIAAKNAELEQELMEKNEKIRSLETNINTEHEKICL----AFEKAKKIHLEQ- 762

Query: 489  GAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPS 548
              K ++ ++ R +    +  QQ    E+ + ++   +   Q  LE+    +  +  ++  
Sbjct: 763  -HKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKK 821

Query: 549  LNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAEL 608
             N +   A++                        L   V++ +++++Q       LD+ L
Sbjct: 822  ENMKKDEALK-----------------------ALQNQVSEETIKVRQ-------LDSAL 851

Query: 609  QLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQES 668
            ++            +E+      QL    ++ E++L++  E +  L  +L++     QE+
Sbjct: 852  EI-----------CKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQET 900

Query: 669  TEEAASLRQELTQQQELYGQAL--QEKVAEVETRLREQLSDTERRLNEARREHAKAVVSL 726
            +E+   L+  L QQQ++  Q      ++ + +T+L +Q+S  E+ L + R   A+ +  +
Sbjct: 901  SEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKM 960

Query: 727  RQIQRRAAQEKE-RSQELRRLQEEAR---------KEEGQRLARRLQELERD-KNLMLAT 775
             +    AA E + + Q++  L   AR         KEE  ++ + +  L+RD +N  +  
Sbjct: 961  EEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHL 1020

Query: 776  LQQEGLLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIK----- 830
             Q + +L + K +         L+KK + V      + S    +  A+  RE ++     
Sbjct: 1021 SQLDMILDQTKTE---------LEKKTNAVKELEKLQHSTETELTEALQKREVLETELQN 1071

Query: 831  --GSLSVLLDDLQDLSEAISKEE 851
              G L   L  LQ+L + + K +
Sbjct: 1072 AHGELKSTLRQLQELRDVLQKAQ 1094



 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 141/657 (21%), Positives = 271/657 (41%), Gaps = 89/657 (13%)

Query: 179  QAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAA 238
            Q ++I +Q      LE   RLL E+  + K     +   L+AL         +   L +A
Sbjct: 795  QQDIICKQ----HHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSA 850

Query: 239  LAGAE---VVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEG---LEKS 292
            L   +   V+  N  EG++ + E+  +   E++  L +  +    SL   +E    L+ +
Sbjct: 851  LEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHT 910

Query: 293  LSSLETRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQ-VTLVENLRKYVGEQVPSEVH 351
            L   +     E     E +     L KQ+SK +++L+ Q  +  E LRK + E+  S  H
Sbjct: 911  LQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRK-MEEKCESAAH 969

Query: 352  SQTWELERQKLLET-----------------MQHLQEDRDSLHATAELLQVRVQSLTHIL 394
                +L+RQK++E                  +  ++++   L    E   + +  L  IL
Sbjct: 970  EA--DLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMIL 1027

Query: 395  ALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQ 454
               + EL +K      LE +     ++ L    +K   L  +L+    E   +++QL+ +
Sbjct: 1028 DQTKTELEKKTNAVKELE-KLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQ-E 1085

Query: 455  VASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASA 514
            +  + +K     +E+    + L  +  E ++E    K   LE+ +A + R    +Q A+ 
Sbjct: 1086 LRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQ 1145

Query: 515  EEQLRLVVNA----VSSSQIWLETTMAKVE----GAAAQLPSLNNRLSYAVRKVHTIRGL 566
               L + +      +    I LE T+ K E        Q+ SLN++L  A  ++      
Sbjct: 1146 VTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQL------ 1199

Query: 567  IARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQG 626
              R+     L+ E             E+ QL++E  R    ++       + V + +EQ 
Sbjct: 1200 --REKEFIMLQNEQ------------EISQLKKEIERTQQRMKE-----MESVMKEQEQY 1240

Query: 627  EAERQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQE------LT 680
             A +    K A  L QEL+ T+E + +   +L  AR  Q ++  E   L  E      L+
Sbjct: 1241 IATQY---KEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLS 1297

Query: 681  QQQELYGQALQEKV-------AEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRR- 732
            ++++ +G  L E++       A +E R++ ++      +   +  +   ++S ++   + 
Sbjct: 1298 KEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKW 1357

Query: 733  ---AAQEKERSQELRRLQEEAR--KEEGQRLARRLQELERDKNLMLATLQQEGLLSR 784
               A  +K   Q+L    E+A+   EE Q     L +  +D+N ++     E LL++
Sbjct: 1358 KISADSQKSSVQQLNEQLEKAKLELEEAQDTVSNLHQQVQDRNEVIEA-ANEALLTK 1413



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 68/330 (20%), Positives = 138/330 (41%), Gaps = 45/330 (13%)

Query: 454 QVASLQEKVTSQSQEQAIL---QRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQ 510
           ++ SL+EK+    Q+ A L     SL  K   +  E   ++     L  AQ       QQ
Sbjct: 230 EIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQ-------QQ 282

Query: 511 TASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARK 570
            AS       ++N        LE   A+V      L    N+L  + + V      I ++
Sbjct: 283 AASVPILEEQIIN--------LE---AEVSAQDKVLREAENKLEQSQKMV------IEKE 325

Query: 571 LALAQLRQESCPLPPPVTDVSLELQQLREERNRL---DAELQLSARLIQQEVGRAREQGE 627
            +L + ++E   L   + + + + ++   +RN       EL  + +  +++V    E+ +
Sbjct: 326 QSLQESKEECIKLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQ 385

Query: 628 AERQQLSKVAQQLEQELQQTQESLASLGLQLEV----ARQGQQESTEEAASLRQELTQQQ 683
           AE + L +     E+E ++ QE       +LE+     RQ ++E+      LR    +  
Sbjct: 386 AEEEILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNS 445

Query: 684 ELYGQALQ--EKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQ 741
           E+  Q  +  + + ++E+ L  +        +E  R+    +   R+++ R A + ER  
Sbjct: 446 EVMAQLTESRQSILKLESELENK--------DEILRDKFSLMNENRELKVRVAAQNER-L 496

Query: 742 ELRRLQEEARKEEGQRLARRLQELERDKNL 771
           +L + + E+ + E + L + + +L   + L
Sbjct: 497 DLCQQEIESSRVELRSLEKIISQLPLKREL 526


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score =  103 bits (257), Expect = 7e-22
 Identities = 151/687 (21%), Positives = 287/687 (41%), Gaps = 88/687 (12%)

Query: 158  RQEPGRRGRSWGLEGSQALSQQAEVIVRQLQELR-RLEEEVRLLRETSLQQKMRLEAQAM 216
            RQE   + +   L+ ++   Q+AE  +++L++   +L EE  LL+E  LQ +  L A+A 
Sbjct: 849  RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQE-QLQAETELYAEAE 907

Query: 217  ELEALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHE 276
            E+     A+K      + L   L   E   +  E+  Q+   E +++ Q+ L    Q  E
Sbjct: 908  EMRVRLAAKK------QELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 961

Query: 277  E--ALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTL 334
            E  A   L  +    E  +  LE        +  +  +E +LL +++S    +L  +   
Sbjct: 962  EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1021

Query: 335  VENLRKYVGEQVPS----EVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQSL 390
             +NL K   +        EV  +  E  RQ+L +  + L+ D    H     LQ ++  L
Sbjct: 1022 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAEL 1081

Query: 391  THILALQEEELTRKVQPSDSLEPEFTRKCQSL--LNRWREKVFALMVQLKAQELEHSDSV 448
               LA +EEEL   +     L+ E  +K  +L  +      +  L   L ++    + + 
Sbjct: 1082 KMQLAKKEEELQAALA---RLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAE 1138

Query: 449  KQLK-----------------GQVASLQEKVTSQSQEQAILQRSLQD--KAAEVEVERMG 489
            KQ +                    A+ QE    + QE  +L+++L +  ++ E +V+ M 
Sbjct: 1139 KQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMR 1198

Query: 490  AKGL--------QLELSRAQEARRRWQQQTASAEE-QLRLVVNAVSSSQIWLETTMAKVE 540
             K          QLE  +  +A     +QT   E   L   +  +  ++  +E    K+E
Sbjct: 1199 QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE 1258

Query: 541  GAAAQLPS-----------LNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTD 589
                +L S           LN+++     +V ++ G+      L +   ++  L   V  
Sbjct: 1259 AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM------LNEAEGKAIKLAKDVAS 1312

Query: 590  VSLEL---QQLREERNRLDAELQLSARLIQQEVGRAREQGEAE---RQQLSKVAQQLEQE 643
            +S +L   Q+L +E  R    +    R +++E    ++Q + E   +Q L +    L  +
Sbjct: 1313 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1372

Query: 644  LQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLRE 703
            L  +++ L      +E   +G++   +E  +L Q+  ++   Y     +K+ + + RL++
Sbjct: 1373 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY-----DKLEKTKNRLQQ 1427

Query: 704  QLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERS----QELRRLQEEARKEEGQ--R 757
            +L D    L+  R+  +      R+  +  A+EK  S     E  R + EAR++E +   
Sbjct: 1428 ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALS 1487

Query: 758  LARRL-------QELERDKNLMLATLQ 777
            LAR L       +ELER   ++ A ++
Sbjct: 1488 LARALEEALEAKEELERTNKMLKAEME 1514



 Score =  100 bits (249), Expect = 6e-21
 Identities = 154/730 (21%), Positives = 311/730 (42%), Gaps = 108/730 (14%)

Query: 190  LRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGA-EVVRKN 248
            L RL++E+   +  +L++   LE    +L+    +E+A R +AE  +  L    E ++  
Sbjct: 1096 LARLDDEIAQ-KNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE 1154

Query: 249  LEE-----GSQREL---------------EEVQRLHQEQLSSLTQAHEEALSSLTSKAEG 288
            LE+      +Q+EL               +E  R H+ Q+  + Q H +A+  LT + E 
Sbjct: 1155 LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1214

Query: 289  LEKSLSSLETRR----------AGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENL 338
             +++ ++L+  +          AGE + L +A++E E  +K+L    ++L+++ +  E  
Sbjct: 1215 FKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERA 1274

Query: 339  RKYVGEQV---PSEVHSQTWELERQ--KLLETMQHLQEDRDSLHATAELLQVRVQSLTHI 393
            R  + ++V    +EV S T  L     K ++  + +      L  T ELLQ   +   ++
Sbjct: 1275 RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNV 1334

Query: 394  LALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLK- 452
                  +L +  +  +SL+ +   + ++  N  R  +  L +QL       SDS K+L+ 
Sbjct: 1335 ----STKLRQLEEERNSLQDQLDEEMEAKQNLERH-ISTLNIQL-------SDSKKKLQD 1382

Query: 453  --GQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQ 510
                V +L+E      +E   L +  ++KAA  +        LQ EL             
Sbjct: 1383 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL----------DDL 1432

Query: 511  TASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARK 570
                + Q +LV N +   Q   +  +A+ +  +++     +R     R+  T    +AR 
Sbjct: 1433 VVDLDNQRQLVSN-LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1491

Query: 571  LALAQLRQESCPLPPPVTDVSLE-LQQLREERNRLDAELQLSARLIQQEVGRAREQGEAE 629
            L  A   +E       +    +E L   +++  +   EL+ S R +           E +
Sbjct: 1492 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRAL-----------ETQ 1540

Query: 630  RQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQ-----QESTEEAASLRQELTQQQE 684
             +++    ++LE ELQ T+++   L + ++ A +GQ     Q   E+    R++L +Q  
Sbjct: 1541 MEEMKTQLEELEDELQATEDAKLRLEVNMQ-ALKGQFERDLQARDEQNEEKRRQLQRQLH 1599

Query: 685  LYGQALQEK------VAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKE 738
             Y   L+++       A  + +L   L D E + + A +   +A+  LR++Q +    + 
Sbjct: 1600 EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQR 1659

Query: 739  RSQELRRLQEE--ARKEEGQRLARRLQ----ELERDKNLMLATLQQEGLLSRYKQQRLLT 792
              ++ R  ++E  A  +E ++ A+ L+    +L+ D    LA  ++    +  +++ L  
Sbjct: 1660 ELEDARASRDEIFATAKENEKKAKSLEADLMQLQED----LAAAERARKQADLEKEELAE 1715

Query: 793  VLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGSLSVLLD-------DLQDLSE 845
             L S L  + ++    R  E    A +A      E  +G++  + D         + LS 
Sbjct: 1716 ELASSLSGRNALQDEKRRLE----ARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSN 1771

Query: 846  AISKEEAVCQ 855
             ++ E +  Q
Sbjct: 1772 ELATERSTAQ 1781



 Score = 91.7 bits (226), Expect = 3e-18
 Identities = 149/618 (24%), Positives = 261/618 (42%), Gaps = 101/618 (16%)

Query: 186  QLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVV 245
            +++  + LE  +  L       K +L+  A  +EAL   +K  + E E L          
Sbjct: 1355 EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAA 1414

Query: 246  RKNLEEGSQRELEEVQRL-----HQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRR 300
               LE+   R  +E+  L     +Q QL S  +  +     L ++ + +    +    R 
Sbjct: 1415 YDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRA 1474

Query: 301  AGEAKE-------LAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQ 353
              EA+E       LA A  EA   +++L +T + L+A++  + + +  VG+ V  E+   
Sbjct: 1475 EAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNV-HELEKS 1533

Query: 354  TWELERQKLLETMQHLQEDRDSLHATAEL---LQVRVQSLTHILALQEEELTRKVQPSDS 410
               LE Q + E    L+E  D L AT +    L+V +Q+L       + +  R +Q  D 
Sbjct: 1534 KRALETQ-MEEMKTQLEELEDELQATEDAKLRLEVNMQAL-------KGQFERDLQARDE 1585

Query: 411  LEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTS--QSQE 468
               E  R+ Q  L+ +  +    +   + Q    + + K+L+G +  L+ +  S  + +E
Sbjct: 1586 QNEEKRRQLQRQLHEYETE----LEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGRE 1641

Query: 469  QAILQ-RSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSS 527
            +AI Q R LQ +           K  Q EL  A+ +R    +  A+A+E  +        
Sbjct: 1642 EAIKQLRKLQAQM----------KDFQRELEDARASR---DEIFATAKENEK-------- 1680

Query: 528  SQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPV 587
                      K +   A L  L   L+ A R         ARK A   L +E        
Sbjct: 1681 ----------KAKSLEADLMQLQEDLAAAER---------ARKQA--DLEKE-------- 1711

Query: 588  TDVSLELQQLREERNRL-DAELQLSARLIQQEVGRAREQG--EAERQQLSKVAQQLEQEL 644
             +++ EL      RN L D + +L AR+ Q E     EQG  EA   ++ K  QQ EQ L
Sbjct: 1712 -ELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ-L 1769

Query: 645  QQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQ----ALQEKVAEVETR 700
                 +  S   + E ARQ  +   +E  S   E+    +   +    AL+ K+A++E +
Sbjct: 1770 SNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ 1829

Query: 701  LREQLSDTERRLNEARREHAKAVVSLRQIQ---RRAAQEKERSQ-------ELRRLQEEA 750
            + ++  + +      +++  K    L Q++   + A Q KE+++       +L+R  EEA
Sbjct: 1830 VEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEA 1889

Query: 751  RKEEGQRLARRLQELERD 768
             +EE QR+    ++L+R+
Sbjct: 1890 -EEESQRINANRRKLQRE 1906



 Score = 57.8 bits (138), Expect = 4e-08
 Identities = 82/344 (23%), Positives = 139/344 (40%), Gaps = 53/344 (15%)

Query: 164  RGRSWGLEGSQALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELE---- 219
            +GR   ++  + L  Q +   R+L++ R   +E+    + + ++   LEA  M+L+    
Sbjct: 1638 KGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLA 1697

Query: 220  ALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEAL 279
            A  RA K    E E L   LA +   R  L++  +R    + +L +E      Q + EA+
Sbjct: 1698 AAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEE--QGNMEAM 1755

Query: 280  SSLTSKAEGLEKSLSS-LETRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENL 338
            S    KA    + LS+ L T R+   K         E  R+QL +  ++L +++  +E  
Sbjct: 1756 SDRVRKATQQAEQLSNELATERSTAQKN--------ESARQQLERQNKELRSKLHEMEGA 1807

Query: 339  RKYVGEQVPSEVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQE 398
             K   +   + + ++  +LE Q         QE R+   AT  L Q + + L  IL   E
Sbjct: 1808 VKSKFKSTIAALEAKIAQLEEQV-------EQEAREKQAATKSLKQ-KDKKLKEILLQVE 1859

Query: 399  EELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASL 458
            +E  RK                            +  Q K Q  + +  VKQLK Q+   
Sbjct: 1860 DE--RK----------------------------MAEQYKEQAEKGNARVKQLKRQLEEA 1889

Query: 459  QEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQE 502
            +E+    +  +  LQR L +     E        L+ +L R  E
Sbjct: 1890 EEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1933



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 52/225 (23%), Positives = 101/225 (44%), Gaps = 15/225 (6%)

Query: 638  QQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQA--LQEKVA 695
            Q  E ELQ+T+E       +L+   Q   + TEE   L+++L  + ELY +A  ++ ++A
Sbjct: 855  QAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLA 914

Query: 696  EVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEG 755
              +  L E L + E RL E               Q+  A+ K+ +Q++  L+E+  +EE 
Sbjct: 915  AKKQELEEILHEMEARLEEEEDRG----------QQLQAERKKMAQQMLDLEEQLEEEEA 964

Query: 756  QRLARRLQELERDKNLMLATLQQEGLLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSA 815
             R   +L+++  +  +      ++ +L    Q   L+    LL+++ S +++    E   
Sbjct: 965  ARQKLQLEKVTAEAKIKKL---EDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1021

Query: 816  SAPVAAAVPTRESIKGSLSVLLDDLQDLSEAISKEEAVCQGDNLD 860
            +  +       ES+   L V L   +   + + K +   +GD  D
Sbjct: 1022 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASD 1066



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 68/274 (24%), Positives = 118/274 (43%), Gaps = 37/274 (13%)

Query: 596  QLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLG 655
            QL EE+N L  +LQ    L   E    R +  A++Q+L ++  ++E  L++ ++      
Sbjct: 884  QLTEEKNLLQEQLQAETELYA-EAEEMRVRLAAKKQELEEILHEMEARLEEEEDR--GQQ 940

Query: 656  LQLEVARQGQQ-----ESTEEAASLRQELTQQQ--------ELYGQAL-----QEKVAEV 697
            LQ E  +  QQ     E  EE  + RQ+L  ++        +L  + L       K+++ 
Sbjct: 941  LQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE 1000

Query: 698  ETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQR 757
               L E++SD    L E   E AK +  L+        E E    +R  +EE  ++E ++
Sbjct: 1001 RKLLEERISDLTTNLAE-EEEKAKNLTKLKNKHESMISELE----VRLKKEEKSRQELEK 1055

Query: 758  LARRLQELERDKNLMLATLQQEGLLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSASA 817
            L R+L+    D +  +A LQ +  ++  K Q         L KK+  + +         A
Sbjct: 1056 LKRKLEGDASDFHEQIADLQAQ--IAELKMQ---------LAKKEEELQAALARLDDEIA 1104

Query: 818  PVAAAVPTRESIKGSLSVLLDDLQDLSEAISKEE 851
                A+     ++G +S L +DL     A +K E
Sbjct: 1105 QKNNALKKIRELEGHISDLQEDLDSERAARNKAE 1138


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score =  103 bits (257), Expect = 7e-22
 Identities = 151/687 (21%), Positives = 287/687 (41%), Gaps = 88/687 (12%)

Query: 158  RQEPGRRGRSWGLEGSQALSQQAEVIVRQLQELR-RLEEEVRLLRETSLQQKMRLEAQAM 216
            RQE   + +   L+ ++   Q+AE  +++L++   +L EE  LL+E  LQ +  L A+A 
Sbjct: 856  RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQE-QLQAETELYAEAE 914

Query: 217  ELEALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHE 276
            E+     A+K      + L   L   E   +  E+  Q+   E +++ Q+ L    Q  E
Sbjct: 915  EMRVRLAAKK------QELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 968

Query: 277  E--ALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTL 334
            E  A   L  +    E  +  LE        +  +  +E +LL +++S    +L  +   
Sbjct: 969  EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1028

Query: 335  VENLRKYVGEQVPS----EVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQSL 390
             +NL K   +        EV  +  E  RQ+L +  + L+ D    H     LQ ++  L
Sbjct: 1029 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAEL 1088

Query: 391  THILALQEEELTRKVQPSDSLEPEFTRKCQSL--LNRWREKVFALMVQLKAQELEHSDSV 448
               LA +EEEL   +     L+ E  +K  +L  +      +  L   L ++    + + 
Sbjct: 1089 KMQLAKKEEELQAALA---RLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAE 1145

Query: 449  KQLK-----------------GQVASLQEKVTSQSQEQAILQRSLQD--KAAEVEVERMG 489
            KQ +                    A+ QE    + QE  +L+++L +  ++ E +V+ M 
Sbjct: 1146 KQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMR 1205

Query: 490  AKGL--------QLELSRAQEARRRWQQQTASAEE-QLRLVVNAVSSSQIWLETTMAKVE 540
             K          QLE  +  +A     +QT   E   L   +  +  ++  +E    K+E
Sbjct: 1206 QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE 1265

Query: 541  GAAAQLPS-----------LNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTD 589
                +L S           LN+++     +V ++ G+      L +   ++  L   V  
Sbjct: 1266 AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM------LNEAEGKAIKLAKDVAS 1319

Query: 590  VSLEL---QQLREERNRLDAELQLSARLIQQEVGRAREQGEAE---RQQLSKVAQQLEQE 643
            +S +L   Q+L +E  R    +    R +++E    ++Q + E   +Q L +    L  +
Sbjct: 1320 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1379

Query: 644  LQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLRE 703
            L  +++ L      +E   +G++   +E  +L Q+  ++   Y     +K+ + + RL++
Sbjct: 1380 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY-----DKLEKTKNRLQQ 1434

Query: 704  QLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERS----QELRRLQEEARKEEGQ--R 757
            +L D    L+  R+  +      R+  +  A+EK  S     E  R + EAR++E +   
Sbjct: 1435 ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALS 1494

Query: 758  LARRL-------QELERDKNLMLATLQ 777
            LAR L       +ELER   ++ A ++
Sbjct: 1495 LARALEEALEAKEELERTNKMLKAEME 1521



 Score =  100 bits (249), Expect = 6e-21
 Identities = 154/730 (21%), Positives = 311/730 (42%), Gaps = 108/730 (14%)

Query: 190  LRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGA-EVVRKN 248
            L RL++E+   +  +L++   LE    +L+    +E+A R +AE  +  L    E ++  
Sbjct: 1103 LARLDDEIAQ-KNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE 1161

Query: 249  LEE-----GSQREL---------------EEVQRLHQEQLSSLTQAHEEALSSLTSKAEG 288
            LE+      +Q+EL               +E  R H+ Q+  + Q H +A+  LT + E 
Sbjct: 1162 LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1221

Query: 289  LEKSLSSLETRR----------AGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENL 338
             +++ ++L+  +          AGE + L +A++E E  +K+L    ++L+++ +  E  
Sbjct: 1222 FKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERA 1281

Query: 339  RKYVGEQV---PSEVHSQTWELERQ--KLLETMQHLQEDRDSLHATAELLQVRVQSLTHI 393
            R  + ++V    +EV S T  L     K ++  + +      L  T ELLQ   +   ++
Sbjct: 1282 RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNV 1341

Query: 394  LALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLK- 452
                  +L +  +  +SL+ +   + ++  N  R  +  L +QL       SDS K+L+ 
Sbjct: 1342 ----STKLRQLEEERNSLQDQLDEEMEAKQNLERH-ISTLNIQL-------SDSKKKLQD 1389

Query: 453  --GQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQ 510
                V +L+E      +E   L +  ++KAA  +        LQ EL             
Sbjct: 1390 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL----------DDL 1439

Query: 511  TASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARK 570
                + Q +LV N +   Q   +  +A+ +  +++     +R     R+  T    +AR 
Sbjct: 1440 VVDLDNQRQLVSN-LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1498

Query: 571  LALAQLRQESCPLPPPVTDVSLE-LQQLREERNRLDAELQLSARLIQQEVGRAREQGEAE 629
            L  A   +E       +    +E L   +++  +   EL+ S R +           E +
Sbjct: 1499 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRAL-----------ETQ 1547

Query: 630  RQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQ-----QESTEEAASLRQELTQQQE 684
             +++    ++LE ELQ T+++   L + ++ A +GQ     Q   E+    R++L +Q  
Sbjct: 1548 MEEMKTQLEELEDELQATEDAKLRLEVNMQ-ALKGQFERDLQARDEQNEEKRRQLQRQLH 1606

Query: 685  LYGQALQEK------VAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKE 738
             Y   L+++       A  + +L   L D E + + A +   +A+  LR++Q +    + 
Sbjct: 1607 EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQR 1666

Query: 739  RSQELRRLQEE--ARKEEGQRLARRLQ----ELERDKNLMLATLQQEGLLSRYKQQRLLT 792
              ++ R  ++E  A  +E ++ A+ L+    +L+ D    LA  ++    +  +++ L  
Sbjct: 1667 ELEDARASRDEIFATAKENEKKAKSLEADLMQLQED----LAAAERARKQADLEKEELAE 1722

Query: 793  VLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGSLSVLLD-------DLQDLSE 845
             L S L  + ++    R  E    A +A      E  +G++  + D         + LS 
Sbjct: 1723 ELASSLSGRNALQDEKRRLE----ARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSN 1778

Query: 846  AISKEEAVCQ 855
             ++ E +  Q
Sbjct: 1779 ELATERSTAQ 1788



 Score = 91.7 bits (226), Expect = 3e-18
 Identities = 149/618 (24%), Positives = 261/618 (42%), Gaps = 101/618 (16%)

Query: 186  QLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVV 245
            +++  + LE  +  L       K +L+  A  +EAL   +K  + E E L          
Sbjct: 1362 EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAA 1421

Query: 246  RKNLEEGSQRELEEVQRL-----HQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRR 300
               LE+   R  +E+  L     +Q QL S  +  +     L ++ + +    +    R 
Sbjct: 1422 YDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRA 1481

Query: 301  AGEAKE-------LAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQ 353
              EA+E       LA A  EA   +++L +T + L+A++  + + +  VG+ V  E+   
Sbjct: 1482 EAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNV-HELEKS 1540

Query: 354  TWELERQKLLETMQHLQEDRDSLHATAEL---LQVRVQSLTHILALQEEELTRKVQPSDS 410
               LE Q + E    L+E  D L AT +    L+V +Q+L       + +  R +Q  D 
Sbjct: 1541 KRALETQ-MEEMKTQLEELEDELQATEDAKLRLEVNMQAL-------KGQFERDLQARDE 1592

Query: 411  LEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTS--QSQE 468
               E  R+ Q  L+ +  +    +   + Q    + + K+L+G +  L+ +  S  + +E
Sbjct: 1593 QNEEKRRQLQRQLHEYETE----LEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGRE 1648

Query: 469  QAILQ-RSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSS 527
            +AI Q R LQ +           K  Q EL  A+ +R    +  A+A+E  +        
Sbjct: 1649 EAIKQLRKLQAQM----------KDFQRELEDARASR---DEIFATAKENEK-------- 1687

Query: 528  SQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPV 587
                      K +   A L  L   L+ A R         ARK A   L +E        
Sbjct: 1688 ----------KAKSLEADLMQLQEDLAAAER---------ARKQA--DLEKE-------- 1718

Query: 588  TDVSLELQQLREERNRL-DAELQLSARLIQQEVGRAREQG--EAERQQLSKVAQQLEQEL 644
             +++ EL      RN L D + +L AR+ Q E     EQG  EA   ++ K  QQ EQ L
Sbjct: 1719 -ELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ-L 1776

Query: 645  QQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQ----ALQEKVAEVETR 700
                 +  S   + E ARQ  +   +E  S   E+    +   +    AL+ K+A++E +
Sbjct: 1777 SNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ 1836

Query: 701  LREQLSDTERRLNEARREHAKAVVSLRQIQ---RRAAQEKERSQ-------ELRRLQEEA 750
            + ++  + +      +++  K    L Q++   + A Q KE+++       +L+R  EEA
Sbjct: 1837 VEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEA 1896

Query: 751  RKEEGQRLARRLQELERD 768
             +EE QR+    ++L+R+
Sbjct: 1897 -EEESQRINANRRKLQRE 1913



 Score = 57.8 bits (138), Expect = 4e-08
 Identities = 82/344 (23%), Positives = 139/344 (40%), Gaps = 53/344 (15%)

Query: 164  RGRSWGLEGSQALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELE---- 219
            +GR   ++  + L  Q +   R+L++ R   +E+    + + ++   LEA  M+L+    
Sbjct: 1645 KGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLA 1704

Query: 220  ALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEAL 279
            A  RA K    E E L   LA +   R  L++  +R    + +L +E      Q + EA+
Sbjct: 1705 AAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEE--QGNMEAM 1762

Query: 280  SSLTSKAEGLEKSLSS-LETRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENL 338
            S    KA    + LS+ L T R+   K         E  R+QL +  ++L +++  +E  
Sbjct: 1763 SDRVRKATQQAEQLSNELATERSTAQKN--------ESARQQLERQNKELRSKLHEMEGA 1814

Query: 339  RKYVGEQVPSEVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQE 398
             K   +   + + ++  +LE Q         QE R+   AT  L Q + + L  IL   E
Sbjct: 1815 VKSKFKSTIAALEAKIAQLEEQV-------EQEAREKQAATKSLKQ-KDKKLKEILLQVE 1866

Query: 399  EELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASL 458
            +E  RK                            +  Q K Q  + +  VKQLK Q+   
Sbjct: 1867 DE--RK----------------------------MAEQYKEQAEKGNARVKQLKRQLEEA 1896

Query: 459  QEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQE 502
            +E+    +  +  LQR L +     E        L+ +L R  E
Sbjct: 1897 EEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1940



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 52/225 (23%), Positives = 101/225 (44%), Gaps = 15/225 (6%)

Query: 638  QQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQA--LQEKVA 695
            Q  E ELQ+T+E       +L+   Q   + TEE   L+++L  + ELY +A  ++ ++A
Sbjct: 862  QAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLA 921

Query: 696  EVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEG 755
              +  L E L + E RL E               Q+  A+ K+ +Q++  L+E+  +EE 
Sbjct: 922  AKKQELEEILHEMEARLEEEEDRG----------QQLQAERKKMAQQMLDLEEQLEEEEA 971

Query: 756  QRLARRLQELERDKNLMLATLQQEGLLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSA 815
             R   +L+++  +  +      ++ +L    Q   L+    LL+++ S +++    E   
Sbjct: 972  ARQKLQLEKVTAEAKIKKL---EDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1028

Query: 816  SAPVAAAVPTRESIKGSLSVLLDDLQDLSEAISKEEAVCQGDNLD 860
            +  +       ES+   L V L   +   + + K +   +GD  D
Sbjct: 1029 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASD 1073



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 68/274 (24%), Positives = 118/274 (43%), Gaps = 37/274 (13%)

Query: 596  QLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLG 655
            QL EE+N L  +LQ    L   E    R +  A++Q+L ++  ++E  L++ ++      
Sbjct: 891  QLTEEKNLLQEQLQAETELYA-EAEEMRVRLAAKKQELEEILHEMEARLEEEEDR--GQQ 947

Query: 656  LQLEVARQGQQ-----ESTEEAASLRQELTQQQ--------ELYGQAL-----QEKVAEV 697
            LQ E  +  QQ     E  EE  + RQ+L  ++        +L  + L       K+++ 
Sbjct: 948  LQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE 1007

Query: 698  ETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQR 757
               L E++SD    L E   E AK +  L+        E E    +R  +EE  ++E ++
Sbjct: 1008 RKLLEERISDLTTNLAE-EEEKAKNLTKLKNKHESMISELE----VRLKKEEKSRQELEK 1062

Query: 758  LARRLQELERDKNLMLATLQQEGLLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSASA 817
            L R+L+    D +  +A LQ +  ++  K Q         L KK+  + +         A
Sbjct: 1063 LKRKLEGDASDFHEQIADLQAQ--IAELKMQ---------LAKKEEELQAALARLDDEIA 1111

Query: 818  PVAAAVPTRESIKGSLSVLLDDLQDLSEAISKEE 851
                A+     ++G +S L +DL     A +K E
Sbjct: 1112 QKNNALKKIRELEGHISDLQEDLDSERAARNKAE 1145


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score =  103 bits (257), Expect = 7e-22
 Identities = 151/687 (21%), Positives = 287/687 (41%), Gaps = 88/687 (12%)

Query: 158  RQEPGRRGRSWGLEGSQALSQQAEVIVRQLQELR-RLEEEVRLLRETSLQQKMRLEAQAM 216
            RQE   + +   L+ ++   Q+AE  +++L++   +L EE  LL+E  LQ +  L A+A 
Sbjct: 856  RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQE-QLQAETELYAEAE 914

Query: 217  ELEALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHE 276
            E+     A+K      + L   L   E   +  E+  Q+   E +++ Q+ L    Q  E
Sbjct: 915  EMRVRLAAKK------QELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 968

Query: 277  E--ALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTL 334
            E  A   L  +    E  +  LE        +  +  +E +LL +++S    +L  +   
Sbjct: 969  EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1028

Query: 335  VENLRKYVGEQVPS----EVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQSL 390
             +NL K   +        EV  +  E  RQ+L +  + L+ D    H     LQ ++  L
Sbjct: 1029 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAEL 1088

Query: 391  THILALQEEELTRKVQPSDSLEPEFTRKCQSL--LNRWREKVFALMVQLKAQELEHSDSV 448
               LA +EEEL   +     L+ E  +K  +L  +      +  L   L ++    + + 
Sbjct: 1089 KMQLAKKEEELQAALA---RLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAE 1145

Query: 449  KQLK-----------------GQVASLQEKVTSQSQEQAILQRSLQD--KAAEVEVERMG 489
            KQ +                    A+ QE    + QE  +L+++L +  ++ E +V+ M 
Sbjct: 1146 KQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMR 1205

Query: 490  AKGL--------QLELSRAQEARRRWQQQTASAEE-QLRLVVNAVSSSQIWLETTMAKVE 540
             K          QLE  +  +A     +QT   E   L   +  +  ++  +E    K+E
Sbjct: 1206 QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE 1265

Query: 541  GAAAQLPS-----------LNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTD 589
                +L S           LN+++     +V ++ G+      L +   ++  L   V  
Sbjct: 1266 AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM------LNEAEGKAIKLAKDVAS 1319

Query: 590  VSLEL---QQLREERNRLDAELQLSARLIQQEVGRAREQGEAE---RQQLSKVAQQLEQE 643
            +S +L   Q+L +E  R    +    R +++E    ++Q + E   +Q L +    L  +
Sbjct: 1320 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1379

Query: 644  LQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLRE 703
            L  +++ L      +E   +G++   +E  +L Q+  ++   Y     +K+ + + RL++
Sbjct: 1380 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY-----DKLEKTKNRLQQ 1434

Query: 704  QLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERS----QELRRLQEEARKEEGQ--R 757
            +L D    L+  R+  +      R+  +  A+EK  S     E  R + EAR++E +   
Sbjct: 1435 ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALS 1494

Query: 758  LARRL-------QELERDKNLMLATLQ 777
            LAR L       +ELER   ++ A ++
Sbjct: 1495 LARALEEALEAKEELERTNKMLKAEME 1521



 Score =  100 bits (249), Expect = 6e-21
 Identities = 154/730 (21%), Positives = 311/730 (42%), Gaps = 108/730 (14%)

Query: 190  LRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGA-EVVRKN 248
            L RL++E+   +  +L++   LE    +L+    +E+A R +AE  +  L    E ++  
Sbjct: 1103 LARLDDEIAQ-KNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE 1161

Query: 249  LEE-----GSQREL---------------EEVQRLHQEQLSSLTQAHEEALSSLTSKAEG 288
            LE+      +Q+EL               +E  R H+ Q+  + Q H +A+  LT + E 
Sbjct: 1162 LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1221

Query: 289  LEKSLSSLETRR----------AGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENL 338
             +++ ++L+  +          AGE + L +A++E E  +K+L    ++L+++ +  E  
Sbjct: 1222 FKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERA 1281

Query: 339  RKYVGEQV---PSEVHSQTWELERQ--KLLETMQHLQEDRDSLHATAELLQVRVQSLTHI 393
            R  + ++V    +EV S T  L     K ++  + +      L  T ELLQ   +   ++
Sbjct: 1282 RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNV 1341

Query: 394  LALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLK- 452
                  +L +  +  +SL+ +   + ++  N  R  +  L +QL       SDS K+L+ 
Sbjct: 1342 ----STKLRQLEEERNSLQDQLDEEMEAKQNLERH-ISTLNIQL-------SDSKKKLQD 1389

Query: 453  --GQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQ 510
                V +L+E      +E   L +  ++KAA  +        LQ EL             
Sbjct: 1390 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL----------DDL 1439

Query: 511  TASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARK 570
                + Q +LV N +   Q   +  +A+ +  +++     +R     R+  T    +AR 
Sbjct: 1440 VVDLDNQRQLVSN-LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1498

Query: 571  LALAQLRQESCPLPPPVTDVSLE-LQQLREERNRLDAELQLSARLIQQEVGRAREQGEAE 629
            L  A   +E       +    +E L   +++  +   EL+ S R +           E +
Sbjct: 1499 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRAL-----------ETQ 1547

Query: 630  RQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQ-----QESTEEAASLRQELTQQQE 684
             +++    ++LE ELQ T+++   L + ++ A +GQ     Q   E+    R++L +Q  
Sbjct: 1548 MEEMKTQLEELEDELQATEDAKLRLEVNMQ-ALKGQFERDLQARDEQNEEKRRQLQRQLH 1606

Query: 685  LYGQALQEK------VAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKE 738
             Y   L+++       A  + +L   L D E + + A +   +A+  LR++Q +    + 
Sbjct: 1607 EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQR 1666

Query: 739  RSQELRRLQEE--ARKEEGQRLARRLQ----ELERDKNLMLATLQQEGLLSRYKQQRLLT 792
              ++ R  ++E  A  +E ++ A+ L+    +L+ D    LA  ++    +  +++ L  
Sbjct: 1667 ELEDARASRDEIFATAKENEKKAKSLEADLMQLQED----LAAAERARKQADLEKEELAE 1722

Query: 793  VLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGSLSVLLD-------DLQDLSE 845
             L S L  + ++    R  E    A +A      E  +G++  + D         + LS 
Sbjct: 1723 ELASSLSGRNALQDEKRRLE----ARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSN 1778

Query: 846  AISKEEAVCQ 855
             ++ E +  Q
Sbjct: 1779 ELATERSTAQ 1788



 Score = 93.2 bits (230), Expect = 9e-19
 Identities = 138/607 (22%), Positives = 272/607 (44%), Gaps = 62/607 (10%)

Query: 186  QLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVV 245
            +++  + LE  +  L       K +L+  A  +EAL   +K  + E E L          
Sbjct: 1362 EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAA 1421

Query: 246  RKNLEEGSQRELEEVQRL-----HQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRR 300
               LE+   R  +E+  L     +Q QL S  +  +     L ++ + +    +    R 
Sbjct: 1422 YDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRA 1481

Query: 301  AGEAKE-------LAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQ 353
              EA+E       LA A  EA   +++L +T + L+A++  + + +  VG+ V  E+   
Sbjct: 1482 EAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNV-HELEKS 1540

Query: 354  TWELERQKLLETMQHLQEDRDSLHATAEL---LQVRVQSLTHILALQEEELTRKVQPSDS 410
               LE Q + E    L+E  D L AT +    L+V +Q+L       + +  R +Q  D 
Sbjct: 1541 KRALETQ-MEEMKTQLEELEDELQATEDAKLRLEVNMQAL-------KGQFERDLQARDE 1592

Query: 411  LEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTS--QSQE 468
               E  R+ Q  L+ +  +    +   + Q    + + K+L+G +  L+ +  S  + +E
Sbjct: 1593 QNEEKRRQLQRQLHEYETE----LEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGRE 1648

Query: 469  QAILQ-RSLQDKAAEVEVERMGAKGLQLEL-SRAQEARRRWQQQTASAEEQLRLVVNAVS 526
            +AI Q R LQ +  + + E   A+  + E+ + A+E  ++ +   A   + ++L  +  +
Sbjct: 1649 EAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEA---DLMQLQEDLAA 1705

Query: 527  SSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPP 586
            + +   +  + K E A     SL+ R +    K    R L AR   +AQL +E       
Sbjct: 1706 AERARKQADLEKEELAEELASSLSGRNALQDEK----RRLEAR---IAQLEEELEEEQGN 1758

Query: 587  VTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQ 646
            +  +S  +++  ++  +L  EL  + R   Q+   AR+Q E + ++L     ++E  ++ 
Sbjct: 1759 MEAMSDRVRKATQQAEQLSNELA-TERSTAQKNESARQQLERQNKELRSKLHEMEGAVKS 1817

Query: 647  TQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLS 706
              +S  +  L+ ++A+   +E  E+ A  +Q  T+  +   + L+E + +VE        
Sbjct: 1818 KFKSTIA-ALEAKIAQL--EEQVEQEAREKQAATKSLKQKDKKLKEILLQVED------- 1867

Query: 707  DTERRLNEARREHA-KAVVSLRQIQRRAAQEKERSQEL----RRLQEEARK--EEGQRLA 759
              ER++ E  +E A K    ++Q++R+  + +E SQ +    R+LQ E  +  E  + + 
Sbjct: 1868 --ERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMG 1925

Query: 760  RRLQELE 766
            R +  L+
Sbjct: 1926 REVNALK 1932



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 74/318 (23%), Positives = 131/318 (41%), Gaps = 39/318 (12%)

Query: 164  RGRSWGLEGSQALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELE---- 219
            +GR   ++  + L  Q +   R+L++ R   +E+    + + ++   LEA  M+L+    
Sbjct: 1645 KGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLA 1704

Query: 220  ALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEAL 279
            A  RA K    E E L   LA +   R  L++  +R    + +L +E      Q + EA+
Sbjct: 1705 AAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEE--QGNMEAM 1762

Query: 280  SSLTSKAEGLEKSLSS-LETRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENL 338
            S    KA    + LS+ L T R+   K         E  R+QL +  ++L +++  +E  
Sbjct: 1763 SDRVRKATQQAEQLSNELATERSTAQKN--------ESARQQLERQNKELRSKLHEMEGA 1814

Query: 339  RKYVGEQVPSEVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQE 398
             K   +   + + ++  +LE Q         QE R+   AT  L Q + + L  IL   E
Sbjct: 1815 VKSKFKSTIAALEAKIAQLEEQV-------EQEAREKQAATKSLKQ-KDKKLKEILLQVE 1866

Query: 399  EELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASL 458
            +E                RK         EK  A + QLK Q  E  +  +++      L
Sbjct: 1867 DE----------------RKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKL 1910

Query: 459  QEKVTSQSQEQAILQRSL 476
            Q ++   ++    + R +
Sbjct: 1911 QRELDEATESNEAMGREV 1928



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 52/225 (23%), Positives = 101/225 (44%), Gaps = 15/225 (6%)

Query: 638  QQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQA--LQEKVA 695
            Q  E ELQ+T+E       +L+   Q   + TEE   L+++L  + ELY +A  ++ ++A
Sbjct: 862  QAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLA 921

Query: 696  EVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEG 755
              +  L E L + E RL E               Q+  A+ K+ +Q++  L+E+  +EE 
Sbjct: 922  AKKQELEEILHEMEARLEEEEDRG----------QQLQAERKKMAQQMLDLEEQLEEEEA 971

Query: 756  QRLARRLQELERDKNLMLATLQQEGLLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSA 815
             R   +L+++  +  +      ++ +L    Q   L+    LL+++ S +++    E   
Sbjct: 972  ARQKLQLEKVTAEAKIKKL---EDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1028

Query: 816  SAPVAAAVPTRESIKGSLSVLLDDLQDLSEAISKEEAVCQGDNLD 860
            +  +       ES+   L V L   +   + + K +   +GD  D
Sbjct: 1029 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASD 1073



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 68/274 (24%), Positives = 118/274 (43%), Gaps = 37/274 (13%)

Query: 596  QLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLG 655
            QL EE+N L  +LQ    L   E    R +  A++Q+L ++  ++E  L++ ++      
Sbjct: 891  QLTEEKNLLQEQLQAETELYA-EAEEMRVRLAAKKQELEEILHEMEARLEEEEDR--GQQ 947

Query: 656  LQLEVARQGQQ-----ESTEEAASLRQELTQQQ--------ELYGQAL-----QEKVAEV 697
            LQ E  +  QQ     E  EE  + RQ+L  ++        +L  + L       K+++ 
Sbjct: 948  LQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE 1007

Query: 698  ETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQR 757
               L E++SD    L E   E AK +  L+        E E    +R  +EE  ++E ++
Sbjct: 1008 RKLLEERISDLTTNLAE-EEEKAKNLTKLKNKHESMISELE----VRLKKEEKSRQELEK 1062

Query: 758  LARRLQELERDKNLMLATLQQEGLLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSASA 817
            L R+L+    D +  +A LQ +  ++  K Q         L KK+  + +         A
Sbjct: 1063 LKRKLEGDASDFHEQIADLQAQ--IAELKMQ---------LAKKEEELQAALARLDDEIA 1111

Query: 818  PVAAAVPTRESIKGSLSVLLDDLQDLSEAISKEE 851
                A+     ++G +S L +DL     A +K E
Sbjct: 1112 QKNNALKKIRELEGHISDLQEDLDSERAARNKAE 1145


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score =  103 bits (257), Expect = 7e-22
 Identities = 151/687 (21%), Positives = 287/687 (41%), Gaps = 88/687 (12%)

Query: 158  RQEPGRRGRSWGLEGSQALSQQAEVIVRQLQELR-RLEEEVRLLRETSLQQKMRLEAQAM 216
            RQE   + +   L+ ++   Q+AE  +++L++   +L EE  LL+E  LQ +  L A+A 
Sbjct: 849  RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQE-QLQAETELYAEAE 907

Query: 217  ELEALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHE 276
            E+     A+K      + L   L   E   +  E+  Q+   E +++ Q+ L    Q  E
Sbjct: 908  EMRVRLAAKK------QELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 961

Query: 277  E--ALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTL 334
            E  A   L  +    E  +  LE        +  +  +E +LL +++S    +L  +   
Sbjct: 962  EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1021

Query: 335  VENLRKYVGEQVPS----EVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQSL 390
             +NL K   +        EV  +  E  RQ+L +  + L+ D    H     LQ ++  L
Sbjct: 1022 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAEL 1081

Query: 391  THILALQEEELTRKVQPSDSLEPEFTRKCQSL--LNRWREKVFALMVQLKAQELEHSDSV 448
               LA +EEEL   +     L+ E  +K  +L  +      +  L   L ++    + + 
Sbjct: 1082 KMQLAKKEEELQAALA---RLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAE 1138

Query: 449  KQLK-----------------GQVASLQEKVTSQSQEQAILQRSLQD--KAAEVEVERMG 489
            KQ +                    A+ QE    + QE  +L+++L +  ++ E +V+ M 
Sbjct: 1139 KQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMR 1198

Query: 490  AKGL--------QLELSRAQEARRRWQQQTASAEE-QLRLVVNAVSSSQIWLETTMAKVE 540
             K          QLE  +  +A     +QT   E   L   +  +  ++  +E    K+E
Sbjct: 1199 QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE 1258

Query: 541  GAAAQLPS-----------LNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTD 589
                +L S           LN+++     +V ++ G+      L +   ++  L   V  
Sbjct: 1259 AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM------LNEAEGKAIKLAKDVAS 1312

Query: 590  VSLEL---QQLREERNRLDAELQLSARLIQQEVGRAREQGEAE---RQQLSKVAQQLEQE 643
            +S +L   Q+L +E  R    +    R +++E    ++Q + E   +Q L +    L  +
Sbjct: 1313 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1372

Query: 644  LQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLRE 703
            L  +++ L      +E   +G++   +E  +L Q+  ++   Y     +K+ + + RL++
Sbjct: 1373 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY-----DKLEKTKNRLQQ 1427

Query: 704  QLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERS----QELRRLQEEARKEEGQ--R 757
            +L D    L+  R+  +      R+  +  A+EK  S     E  R + EAR++E +   
Sbjct: 1428 ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALS 1487

Query: 758  LARRL-------QELERDKNLMLATLQ 777
            LAR L       +ELER   ++ A ++
Sbjct: 1488 LARALEEALEAKEELERTNKMLKAEME 1514



 Score =  100 bits (249), Expect = 6e-21
 Identities = 154/730 (21%), Positives = 311/730 (42%), Gaps = 108/730 (14%)

Query: 190  LRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGA-EVVRKN 248
            L RL++E+   +  +L++   LE    +L+    +E+A R +AE  +  L    E ++  
Sbjct: 1096 LARLDDEIAQ-KNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE 1154

Query: 249  LEE-----GSQREL---------------EEVQRLHQEQLSSLTQAHEEALSSLTSKAEG 288
            LE+      +Q+EL               +E  R H+ Q+  + Q H +A+  LT + E 
Sbjct: 1155 LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1214

Query: 289  LEKSLSSLETRR----------AGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENL 338
             +++ ++L+  +          AGE + L +A++E E  +K+L    ++L+++ +  E  
Sbjct: 1215 FKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERA 1274

Query: 339  RKYVGEQV---PSEVHSQTWELERQ--KLLETMQHLQEDRDSLHATAELLQVRVQSLTHI 393
            R  + ++V    +EV S T  L     K ++  + +      L  T ELLQ   +   ++
Sbjct: 1275 RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNV 1334

Query: 394  LALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLK- 452
                  +L +  +  +SL+ +   + ++  N  R  +  L +QL       SDS K+L+ 
Sbjct: 1335 ----STKLRQLEEERNSLQDQLDEEMEAKQNLERH-ISTLNIQL-------SDSKKKLQD 1382

Query: 453  --GQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQ 510
                V +L+E      +E   L +  ++KAA  +        LQ EL             
Sbjct: 1383 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL----------DDL 1432

Query: 511  TASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARK 570
                + Q +LV N +   Q   +  +A+ +  +++     +R     R+  T    +AR 
Sbjct: 1433 VVDLDNQRQLVSN-LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1491

Query: 571  LALAQLRQESCPLPPPVTDVSLE-LQQLREERNRLDAELQLSARLIQQEVGRAREQGEAE 629
            L  A   +E       +    +E L   +++  +   EL+ S R +           E +
Sbjct: 1492 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRAL-----------ETQ 1540

Query: 630  RQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQ-----QESTEEAASLRQELTQQQE 684
             +++    ++LE ELQ T+++   L + ++ A +GQ     Q   E+    R++L +Q  
Sbjct: 1541 MEEMKTQLEELEDELQATEDAKLRLEVNMQ-ALKGQFERDLQARDEQNEEKRRQLQRQLH 1599

Query: 685  LYGQALQEK------VAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKE 738
             Y   L+++       A  + +L   L D E + + A +   +A+  LR++Q +    + 
Sbjct: 1600 EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQR 1659

Query: 739  RSQELRRLQEE--ARKEEGQRLARRLQ----ELERDKNLMLATLQQEGLLSRYKQQRLLT 792
              ++ R  ++E  A  +E ++ A+ L+    +L+ D    LA  ++    +  +++ L  
Sbjct: 1660 ELEDARASRDEIFATAKENEKKAKSLEADLMQLQED----LAAAERARKQADLEKEELAE 1715

Query: 793  VLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGSLSVLLD-------DLQDLSE 845
             L S L  + ++    R  E    A +A      E  +G++  + D         + LS 
Sbjct: 1716 ELASSLSGRNALQDEKRRLE----ARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSN 1771

Query: 846  AISKEEAVCQ 855
             ++ E +  Q
Sbjct: 1772 ELATERSTAQ 1781



 Score = 93.2 bits (230), Expect = 9e-19
 Identities = 138/607 (22%), Positives = 272/607 (44%), Gaps = 62/607 (10%)

Query: 186  QLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVV 245
            +++  + LE  +  L       K +L+  A  +EAL   +K  + E E L          
Sbjct: 1355 EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAA 1414

Query: 246  RKNLEEGSQRELEEVQRL-----HQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRR 300
               LE+   R  +E+  L     +Q QL S  +  +     L ++ + +    +    R 
Sbjct: 1415 YDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRA 1474

Query: 301  AGEAKE-------LAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQ 353
              EA+E       LA A  EA   +++L +T + L+A++  + + +  VG+ V  E+   
Sbjct: 1475 EAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNV-HELEKS 1533

Query: 354  TWELERQKLLETMQHLQEDRDSLHATAEL---LQVRVQSLTHILALQEEELTRKVQPSDS 410
               LE Q + E    L+E  D L AT +    L+V +Q+L       + +  R +Q  D 
Sbjct: 1534 KRALETQ-MEEMKTQLEELEDELQATEDAKLRLEVNMQAL-------KGQFERDLQARDE 1585

Query: 411  LEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTS--QSQE 468
               E  R+ Q  L+ +  +    +   + Q    + + K+L+G +  L+ +  S  + +E
Sbjct: 1586 QNEEKRRQLQRQLHEYETE----LEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGRE 1641

Query: 469  QAILQ-RSLQDKAAEVEVERMGAKGLQLEL-SRAQEARRRWQQQTASAEEQLRLVVNAVS 526
            +AI Q R LQ +  + + E   A+  + E+ + A+E  ++ +   A   + ++L  +  +
Sbjct: 1642 EAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEA---DLMQLQEDLAA 1698

Query: 527  SSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPP 586
            + +   +  + K E A     SL+ R +    K    R L AR   +AQL +E       
Sbjct: 1699 AERARKQADLEKEELAEELASSLSGRNALQDEK----RRLEAR---IAQLEEELEEEQGN 1751

Query: 587  VTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQ 646
            +  +S  +++  ++  +L  EL  + R   Q+   AR+Q E + ++L     ++E  ++ 
Sbjct: 1752 MEAMSDRVRKATQQAEQLSNELA-TERSTAQKNESARQQLERQNKELRSKLHEMEGAVKS 1810

Query: 647  TQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLS 706
              +S  +  L+ ++A+   +E  E+ A  +Q  T+  +   + L+E + +VE        
Sbjct: 1811 KFKSTIA-ALEAKIAQL--EEQVEQEAREKQAATKSLKQKDKKLKEILLQVED------- 1860

Query: 707  DTERRLNEARREHA-KAVVSLRQIQRRAAQEKERSQEL----RRLQEEARK--EEGQRLA 759
              ER++ E  +E A K    ++Q++R+  + +E SQ +    R+LQ E  +  E  + + 
Sbjct: 1861 --ERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMG 1918

Query: 760  RRLQELE 766
            R +  L+
Sbjct: 1919 REVNALK 1925



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 74/318 (23%), Positives = 131/318 (41%), Gaps = 39/318 (12%)

Query: 164  RGRSWGLEGSQALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELE---- 219
            +GR   ++  + L  Q +   R+L++ R   +E+    + + ++   LEA  M+L+    
Sbjct: 1638 KGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLA 1697

Query: 220  ALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEAL 279
            A  RA K    E E L   LA +   R  L++  +R    + +L +E      Q + EA+
Sbjct: 1698 AAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEE--QGNMEAM 1755

Query: 280  SSLTSKAEGLEKSLSS-LETRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENL 338
            S    KA    + LS+ L T R+   K         E  R+QL +  ++L +++  +E  
Sbjct: 1756 SDRVRKATQQAEQLSNELATERSTAQKN--------ESARQQLERQNKELRSKLHEMEGA 1807

Query: 339  RKYVGEQVPSEVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQE 398
             K   +   + + ++  +LE Q         QE R+   AT  L Q + + L  IL   E
Sbjct: 1808 VKSKFKSTIAALEAKIAQLEEQV-------EQEAREKQAATKSLKQ-KDKKLKEILLQVE 1859

Query: 399  EELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASL 458
            +E                RK         EK  A + QLK Q  E  +  +++      L
Sbjct: 1860 DE----------------RKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKL 1903

Query: 459  QEKVTSQSQEQAILQRSL 476
            Q ++   ++    + R +
Sbjct: 1904 QRELDEATESNEAMGREV 1921



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 52/225 (23%), Positives = 101/225 (44%), Gaps = 15/225 (6%)

Query: 638  QQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQA--LQEKVA 695
            Q  E ELQ+T+E       +L+   Q   + TEE   L+++L  + ELY +A  ++ ++A
Sbjct: 855  QAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLA 914

Query: 696  EVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEG 755
              +  L E L + E RL E               Q+  A+ K+ +Q++  L+E+  +EE 
Sbjct: 915  AKKQELEEILHEMEARLEEEEDRG----------QQLQAERKKMAQQMLDLEEQLEEEEA 964

Query: 756  QRLARRLQELERDKNLMLATLQQEGLLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSA 815
             R   +L+++  +  +      ++ +L    Q   L+    LL+++ S +++    E   
Sbjct: 965  ARQKLQLEKVTAEAKIKKL---EDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1021

Query: 816  SAPVAAAVPTRESIKGSLSVLLDDLQDLSEAISKEEAVCQGDNLD 860
            +  +       ES+   L V L   +   + + K +   +GD  D
Sbjct: 1022 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASD 1066



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 68/274 (24%), Positives = 118/274 (43%), Gaps = 37/274 (13%)

Query: 596  QLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLG 655
            QL EE+N L  +LQ    L   E    R +  A++Q+L ++  ++E  L++ ++      
Sbjct: 884  QLTEEKNLLQEQLQAETELYA-EAEEMRVRLAAKKQELEEILHEMEARLEEEEDR--GQQ 940

Query: 656  LQLEVARQGQQ-----ESTEEAASLRQELTQQQ--------ELYGQAL-----QEKVAEV 697
            LQ E  +  QQ     E  EE  + RQ+L  ++        +L  + L       K+++ 
Sbjct: 941  LQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE 1000

Query: 698  ETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQR 757
               L E++SD    L E   E AK +  L+        E E    +R  +EE  ++E ++
Sbjct: 1001 RKLLEERISDLTTNLAE-EEEKAKNLTKLKNKHESMISELE----VRLKKEEKSRQELEK 1055

Query: 758  LARRLQELERDKNLMLATLQQEGLLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSASA 817
            L R+L+    D +  +A LQ +  ++  K Q         L KK+  + +         A
Sbjct: 1056 LKRKLEGDASDFHEQIADLQAQ--IAELKMQ---------LAKKEEELQAALARLDDEIA 1104

Query: 818  PVAAAVPTRESIKGSLSVLLDDLQDLSEAISKEE 851
                A+     ++G +S L +DL     A +K E
Sbjct: 1105 QKNNALKKIRELEGHISDLQEDLDSERAARNKAE 1138


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.312    0.125    0.341 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,812,064
Number of Sequences: 37866
Number of extensions: 1449807
Number of successful extensions: 24084
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 459
Number of HSP's successfully gapped in prelim test: 1222
Number of HSP's that attempted gapping in prelim test: 8437
Number of HSP's gapped (non-prelim): 6938
length of query: 871
length of database: 18,247,518
effective HSP length: 111
effective length of query: 760
effective length of database: 14,044,392
effective search space: 10673737920
effective search space used: 10673737920
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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