Search of human proteins with 157671929

Search of human proteins with 157671929

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|157671929 phosphoinositide-3-kinase, class 2 alpha
polypeptide [Homo sapiens]
         (1686 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|157671929 phosphoinositide-3-kinase, class 2 alpha polypeptid...  3369   0.0  
gi|194097347 phosphoinositide-3-kinase, class 2 beta polypeptide...  1328   0.0  
gi|194353959 phosphoinositide-3-kinase, class 2 gamma polypeptid...   735   0.0  
gi|21237725 phosphoinositide-3-kinase, catalytic, gamma polypept...   388   e-107
gi|54792082 phosphoinositide-3-kinase, catalytic, alpha polypept...   375   e-103
gi|156564405 catalytic phosphatidylinositol 3-kinase delta [Homo...   363   e-100
gi|5453894 catalytic phosphatidylinositol 3-kinase beta [Homo sa...   360   6e-99
gi|34761064 catalytic phosphatidylinositol 3-kinase 3 [Homo sapi...   173   1e-42
gi|4505807 phosphatidylinositol 4-kinase type 3 alpha isoform 1 ...   127   7e-29
gi|155030226 phosphatidylinositol 4-kinase type 3 alpha isoform ...   127   7e-29
gi|4505809 catalytic phosphatidylinositol 4-kinase beta [Homo sa...   108   6e-23
gi|239757646 PREDICTED: similar to phosphatidylinositol 4-kinase...    85   7e-16
gi|15011902 synaptotagmin-like 2 isoform a [Homo sapiens]              82   6e-15
gi|244790016 synaptotagmin-like 2 isoform h [Homo sapiens]             82   6e-15
gi|254039650 synaptotagmin-like 5 isoform 1 [Homo sapiens]             79   3e-14
gi|254039648 synaptotagmin-like 5 isoform 2 [Homo sapiens]             79   3e-14
gi|20270305 synaptotagmin-like 5 isoform 1 [Homo sapiens]              79   3e-14
gi|15011900 synaptotagmin-like 2 isoform b [Homo sapiens]              79   4e-14
gi|244790020 synaptotagmin-like 2 isoform i [Homo sapiens]             79   4e-14
gi|244790013 synaptotagmin-like 2 isoform g [Homo sapiens]             79   4e-14
gi|46255068 synaptotagmin-like 2 isoform f [Homo sapiens]              79   4e-14
gi|46255066 synaptotagmin-like 2 isoform e [Homo sapiens]              79   4e-14
gi|46255064 synaptotagmin-like 2 isoform d [Homo sapiens]              79   4e-14
gi|46255062 synaptotagmin-like 2 isoform c [Homo sapiens]              79   4e-14
gi|193804862 synaptotagmin-like 4 [Homo sapiens]                       77   1e-13
gi|193804860 synaptotagmin-like 4 [Homo sapiens]                       77   1e-13
gi|150170670 piccolo isoform 2 [Homo sapiens]                          76   3e-13
gi|150378539 piccolo isoform 1 [Homo sapiens]                          76   3e-13
gi|14249614 synaptotagmin-like 1 [Homo sapiens]                        75   5e-13
gi|154354981 regulating synaptic membrane exocytosis 2 isoform b...    72   3e-12

>gi|157671929 phosphoinositide-3-kinase, class 2 alpha polypeptide
            [Homo sapiens]
          Length = 1686

 Score = 3369 bits (8736), Expect = 0.0
 Identities = 1686/1686 (100%), Positives = 1686/1686 (100%)

Query: 1    MAQISSNSGFKECPSSHPEPTRAKDVDKEEALQMEAEALAKLQKDRQVTDNQRGFELSSS 60
            MAQISSNSGFKECPSSHPEPTRAKDVDKEEALQMEAEALAKLQKDRQVTDNQRGFELSSS
Sbjct: 1    MAQISSNSGFKECPSSHPEPTRAKDVDKEEALQMEAEALAKLQKDRQVTDNQRGFELSSS 60

Query: 61   TRKKAQVYNKQDYDLMVFPESDSQKRALDIDVEKLTQAELEKLLLDDSFETKKTPVLPVT 120
            TRKKAQVYNKQDYDLMVFPESDSQKRALDIDVEKLTQAELEKLLLDDSFETKKTPVLPVT
Sbjct: 61   TRKKAQVYNKQDYDLMVFPESDSQKRALDIDVEKLTQAELEKLLLDDSFETKKTPVLPVT 120

Query: 121  PILSPSFSAQLYFRPTIQRGQWPPGLPGPSTYALPSIYPSTYSKQAAFQNGFNPRMPTFP 180
            PILSPSFSAQLYFRPTIQRGQWPPGLPGPSTYALPSIYPSTYSKQAAFQNGFNPRMPTFP
Sbjct: 121  PILSPSFSAQLYFRPTIQRGQWPPGLPGPSTYALPSIYPSTYSKQAAFQNGFNPRMPTFP 180

Query: 181  STEPIYLSLPGQSPYFSYPLTPATPFHPQGSLPIYRPVVSTDMAKLFDKIASTSEFLKNG 240
            STEPIYLSLPGQSPYFSYPLTPATPFHPQGSLPIYRPVVSTDMAKLFDKIASTSEFLKNG
Sbjct: 181  STEPIYLSLPGQSPYFSYPLTPATPFHPQGSLPIYRPVVSTDMAKLFDKIASTSEFLKNG 240

Query: 241  KARTDLEITDSKVSNLQVSPKSEDISKFDWLDLDPLSKPKVDNVEVLDHEEEKNVSSLLA 300
            KARTDLEITDSKVSNLQVSPKSEDISKFDWLDLDPLSKPKVDNVEVLDHEEEKNVSSLLA
Sbjct: 241  KARTDLEITDSKVSNLQVSPKSEDISKFDWLDLDPLSKPKVDNVEVLDHEEEKNVSSLLA 300

Query: 301  KDPWDAVLLEERSTANCHLERKVNGKSLSVATVTRSQSLNIRTTQLAKAQGHISQKDPNG 360
            KDPWDAVLLEERSTANCHLERKVNGKSLSVATVTRSQSLNIRTTQLAKAQGHISQKDPNG
Sbjct: 301  KDPWDAVLLEERSTANCHLERKVNGKSLSVATVTRSQSLNIRTTQLAKAQGHISQKDPNG 360

Query: 361  TSSLPTGSSLLQEVEVQNEEMAAFCRSITKLKTKFPYTNHRTNPGYLLSPVTAQRNICGE 420
            TSSLPTGSSLLQEVEVQNEEMAAFCRSITKLKTKFPYTNHRTNPGYLLSPVTAQRNICGE
Sbjct: 361  TSSLPTGSSLLQEVEVQNEEMAAFCRSITKLKTKFPYTNHRTNPGYLLSPVTAQRNICGE 420

Query: 421  NASVKVSIDIEGFQLPVTFTCDVSSTVEIIIMQALCWVHDDLNQVDVGSYVLKVCGQEEV 480
            NASVKVSIDIEGFQLPVTFTCDVSSTVEIIIMQALCWVHDDLNQVDVGSYVLKVCGQEEV
Sbjct: 421  NASVKVSIDIEGFQLPVTFTCDVSSTVEIIIMQALCWVHDDLNQVDVGSYVLKVCGQEEV 480

Query: 481  LQNNHCLGSHEHIQNCRKWDTEIRLQLLTFSAMCQNLARTAEDDETPVDLNKHLYQIEKP 540
            LQNNHCLGSHEHIQNCRKWDTEIRLQLLTFSAMCQNLARTAEDDETPVDLNKHLYQIEKP
Sbjct: 481  LQNNHCLGSHEHIQNCRKWDTEIRLQLLTFSAMCQNLARTAEDDETPVDLNKHLYQIEKP 540

Query: 541  CKEAMTRHPVEELLDSYHNQVELALQIENQHRAVDQVIKAVRKICSALDGVETLAITESV 600
            CKEAMTRHPVEELLDSYHNQVELALQIENQHRAVDQVIKAVRKICSALDGVETLAITESV
Sbjct: 541  CKEAMTRHPVEELLDSYHNQVELALQIENQHRAVDQVIKAVRKICSALDGVETLAITESV 600

Query: 601  KKLKRAVNLPRSKTADVTSLFGGEDTSRSSTRGSLNPENPVQVSINQLTAAIYDLLRLHA 660
            KKLKRAVNLPRSKTADVTSLFGGEDTSRSSTRGSLNPENPVQVSINQLTAAIYDLLRLHA
Sbjct: 601  KKLKRAVNLPRSKTADVTSLFGGEDTSRSSTRGSLNPENPVQVSINQLTAAIYDLLRLHA 660

Query: 661  NSGRSPTDCAQSSKSVKEAWTTTEQLQFTIFAAHGISSNWVSNYEKYYLICSLSHNGKDL 720
            NSGRSPTDCAQSSKSVKEAWTTTEQLQFTIFAAHGISSNWVSNYEKYYLICSLSHNGKDL
Sbjct: 661  NSGRSPTDCAQSSKSVKEAWTTTEQLQFTIFAAHGISSNWVSNYEKYYLICSLSHNGKDL 720

Query: 721  FKPIQSKKVGTYKNFFYLIKWDELIIFPIQISQLPLESVLHLTLFGILNQSSGSSPDSNK 780
            FKPIQSKKVGTYKNFFYLIKWDELIIFPIQISQLPLESVLHLTLFGILNQSSGSSPDSNK
Sbjct: 721  FKPIQSKKVGTYKNFFYLIKWDELIIFPIQISQLPLESVLHLTLFGILNQSSGSSPDSNK 780

Query: 781  QRKGPEALGKVSLPLFDFKRFLTCGTKLLYLWTSSHTNSVPGTVTKKGYVMERIVLQVDF 840
            QRKGPEALGKVSLPLFDFKRFLTCGTKLLYLWTSSHTNSVPGTVTKKGYVMERIVLQVDF
Sbjct: 781  QRKGPEALGKVSLPLFDFKRFLTCGTKLLYLWTSSHTNSVPGTVTKKGYVMERIVLQVDF 840

Query: 841  PSPAFDIIYTTPQVDRSIIQQHNLETLENDIKGKLLDILHKDSSLGLSKEDKAFLWEKRY 900
            PSPAFDIIYTTPQVDRSIIQQHNLETLENDIKGKLLDILHKDSSLGLSKEDKAFLWEKRY
Sbjct: 841  PSPAFDIIYTTPQVDRSIIQQHNLETLENDIKGKLLDILHKDSSLGLSKEDKAFLWEKRY 900

Query: 901  YCFKHPNCLPKILASAPNWKWVNLAKTYSLLHQWPALYPLIALELLDSKFADQEVRSLAV 960
            YCFKHPNCLPKILASAPNWKWVNLAKTYSLLHQWPALYPLIALELLDSKFADQEVRSLAV
Sbjct: 901  YCFKHPNCLPKILASAPNWKWVNLAKTYSLLHQWPALYPLIALELLDSKFADQEVRSLAV 960

Query: 961  TWIEAISDDELTDLLPQFVQALKYEIYLNSSLVQFLLSRALGNIQIAHNLYWLLKDALHD 1020
            TWIEAISDDELTDLLPQFVQALKYEIYLNSSLVQFLLSRALGNIQIAHNLYWLLKDALHD
Sbjct: 961  TWIEAISDDELTDLLPQFVQALKYEIYLNSSLVQFLLSRALGNIQIAHNLYWLLKDALHD 1020

Query: 1021 VQFSTRYEHVLGALLSVGGKRLREELLKQTKLVQLLGGVAEKVRQASGSARQVVLQRSME 1080
            VQFSTRYEHVLGALLSVGGKRLREELLKQTKLVQLLGGVAEKVRQASGSARQVVLQRSME
Sbjct: 1021 VQFSTRYEHVLGALLSVGGKRLREELLKQTKLVQLLGGVAEKVRQASGSARQVVLQRSME 1080

Query: 1081 RVQSFFQKNKCRLPLKPSLVAKELNIKSCSFFSSNAVPLKVTMVNADPMGEEINVMFKVG 1140
            RVQSFFQKNKCRLPLKPSLVAKELNIKSCSFFSSNAVPLKVTMVNADPMGEEINVMFKVG
Sbjct: 1081 RVQSFFQKNKCRLPLKPSLVAKELNIKSCSFFSSNAVPLKVTMVNADPMGEEINVMFKVG 1140

Query: 1141 EDLRQDMLALQMIKIMDKIWLKEGLDLRMVIFKCLSTGRDRGMVELVPASDTLRKIQVEY 1200
            EDLRQDMLALQMIKIMDKIWLKEGLDLRMVIFKCLSTGRDRGMVELVPASDTLRKIQVEY
Sbjct: 1141 EDLRQDMLALQMIKIMDKIWLKEGLDLRMVIFKCLSTGRDRGMVELVPASDTLRKIQVEY 1200

Query: 1201 GVTGSFKDKPLAEWLRKYNPSEEEYEKASENFIYSCAGCCVATYVLGICDRHNDNIMLRS 1260
            GVTGSFKDKPLAEWLRKYNPSEEEYEKASENFIYSCAGCCVATYVLGICDRHNDNIMLRS
Sbjct: 1201 GVTGSFKDKPLAEWLRKYNPSEEEYEKASENFIYSCAGCCVATYVLGICDRHNDNIMLRS 1260

Query: 1261 TGHMFHIDFGKFLGHAQMFGSFKRDRAPFVLTSDMAYVINGGEKPTIRFQLFVDLCCQAY 1320
            TGHMFHIDFGKFLGHAQMFGSFKRDRAPFVLTSDMAYVINGGEKPTIRFQLFVDLCCQAY
Sbjct: 1261 TGHMFHIDFGKFLGHAQMFGSFKRDRAPFVLTSDMAYVINGGEKPTIRFQLFVDLCCQAY 1320

Query: 1321 NLIRKQTNLFLNLLSLMIPSGLPELTSIQDLKYVRDALQPQTTDAEATIFFTRLIESSLG 1380
            NLIRKQTNLFLNLLSLMIPSGLPELTSIQDLKYVRDALQPQTTDAEATIFFTRLIESSLG
Sbjct: 1321 NLIRKQTNLFLNLLSLMIPSGLPELTSIQDLKYVRDALQPQTTDAEATIFFTRLIESSLG 1380

Query: 1381 SIATKFNFFIHNLAQLRFSGLPSNDEPILSFSPKTYSFRQDGRIKEVSVFTYHKKYNPDK 1440
            SIATKFNFFIHNLAQLRFSGLPSNDEPILSFSPKTYSFRQDGRIKEVSVFTYHKKYNPDK
Sbjct: 1381 SIATKFNFFIHNLAQLRFSGLPSNDEPILSFSPKTYSFRQDGRIKEVSVFTYHKKYNPDK 1440

Query: 1441 HYIYVVRILREGQIEPSFVFRTFDEFQELHNKLSIIFPLWKLPGFPNRMVLGRTHIKDVA 1500
            HYIYVVRILREGQIEPSFVFRTFDEFQELHNKLSIIFPLWKLPGFPNRMVLGRTHIKDVA
Sbjct: 1441 HYIYVVRILREGQIEPSFVFRTFDEFQELHNKLSIIFPLWKLPGFPNRMVLGRTHIKDVA 1500

Query: 1501 AKRKIELNSYLQSLMNASTDVAECDLVCTFFHPLLRDEKAEGIARSADAGSFSPTPGQIG 1560
            AKRKIELNSYLQSLMNASTDVAECDLVCTFFHPLLRDEKAEGIARSADAGSFSPTPGQIG
Sbjct: 1501 AKRKIELNSYLQSLMNASTDVAECDLVCTFFHPLLRDEKAEGIARSADAGSFSPTPGQIG 1560

Query: 1561 GAVKLSISYRNGTLFIMVMHIKDLVTEDGADPNPYVKTYLLPDNHKTSKRKTKISRKTRN 1620
            GAVKLSISYRNGTLFIMVMHIKDLVTEDGADPNPYVKTYLLPDNHKTSKRKTKISRKTRN
Sbjct: 1561 GAVKLSISYRNGTLFIMVMHIKDLVTEDGADPNPYVKTYLLPDNHKTSKRKTKISRKTRN 1620

Query: 1621 PTFNEMLVYSGYSKETLRQRELQLSVLSAESLRENFFLGGVTLPLKDFNLSKETVKWYQL 1680
            PTFNEMLVYSGYSKETLRQRELQLSVLSAESLRENFFLGGVTLPLKDFNLSKETVKWYQL
Sbjct: 1621 PTFNEMLVYSGYSKETLRQRELQLSVLSAESLRENFFLGGVTLPLKDFNLSKETVKWYQL 1680

Query: 1681 TAATYL 1686
            TAATYL
Sbjct: 1681 TAATYL 1686


>gi|194097347 phosphoinositide-3-kinase, class 2 beta polypeptide
            [Homo sapiens]
          Length = 1634

 Score = 1328 bits (3437), Expect = 0.0
 Identities = 688/1332 (51%), Positives = 931/1332 (69%), Gaps = 27/1332 (2%)

Query: 363  SLPTGSSLLQEVEVQNEEMAAFCRSITKLKTKFPYTNHRTNPGYLLSPVTAQRNICGENA 422
            ++  G  L +  E ++EE+AAFC  +  L++     ++    GY+ S VT      G+  
Sbjct: 318  TVANGHELFEVSEERDEEVAAFCHMLDILRSGSDIQDYFLT-GYVWSAVTPSPEHLGDEV 376

Query: 423  SVKVSIDIEGFQLPVTFTCDVSSTVEIIIMQALCWVHDDLNQVDVGSYVLKVCGQEEVLQ 482
            ++KV++  +  Q  +TFTC+ SSTV+++I Q LC+ HDDL  VDVG +VLK CG EE LQ
Sbjct: 377  NLKVTVLCDRLQEALTFTCNCSSTVDLLIYQTLCYTHDDLRNVDVGDFVLKPCGLEEFLQ 436

Query: 483  NNHCLGSHEHIQNCRKWDTEIRLQLLTFSAMCQNLARTAEDDETPVDLNKHLYQIEKPCK 542
            N H LGSHE+IQ CRK+D +IRLQL+    +  +LART  DD++P  LN  ++  E+P K
Sbjct: 437  NKHALGSHEYIQYCRKFDIDIRLQLMEQKVVRSDLARTVNDDQSPSTLNYLVHLQERPVK 496

Query: 543  EAMTRHPVEELLDSYHNQVELALQIENQHRA-VDQVIKAVRKICSALDGVETLAITESVK 601
            + ++R  +  L D+YHN+V+  L  +       D+V+++V+ IC+AL  VET  IT ++ 
Sbjct: 497  QTISRQALSLLFDTYHNEVDAFLLADGDFPLKADRVVQSVKAICNALAAVETPEITSALN 556

Query: 602  KLKRAVNLPRSKTADVTSLFGGEDTSRSSTRGSLNPENPVQVSINQLTAAIYDLLRLHAN 661
            +L    +  + K          +D S  + R     EN  +V +  LTAAI DL+ L+ N
Sbjct: 557  QLPPCPSRMQPKIQ--------KDPSVLAVR-----ENREKV-VEALTAAILDLVELYCN 602

Query: 662  SGRSPTDCA----QSSKSVKEAWTTTEQLQFTIFAAHGISSNWVSNYEKYYLICSLSHNG 717
            +  +    A    +    V+EA      L FT++A H I   W ++YE +YL CSLSH G
Sbjct: 603  TFNADFQTAVPGSRKHDLVQEACHFARSLAFTVYATHRIPIIWATSYEDFYLSCSLSHGG 662

Query: 718  KDLFKPIQSKKVGTYKNFFYLIKWDELIIFPIQISQLPLESVLHLTLFGILNQSSGSSPD 777
            K+L  P+Q+++    K  F+LI WD+ I FP+Q+++LP E++L  TL+ +     GSS +
Sbjct: 663  KELCSPLQTRRAHFSKYLFHLIVWDQQICFPVQVNRLPRETLLCATLYALPIPPPGSSSE 722

Query: 778  SNKQRKGPEALGKVSLPLFDFKRFLTCGTKLLYLWTSSHTNSVPGTVTKKGYVMERIVLQ 837
            +NKQR+ PEALG V+ PLF+F++ LTCG KLL LW ++  N          +  + ++LQ
Sbjct: 723  ANKQRRVPEALGWVTTPLFNFRQVLTCGRKLLGLWPATQENPSARWSAPNFHQPDSVILQ 782

Query: 838  VDFPSPAFDIIYTTPQVDRSIIQQHNLETLENDIKGKLLDILHKDSSLGLSKEDKAFLWE 897
            +DFP+ AFDI +T+P  D+    ++   +L  + + KL DI+ K+S   L+  DK  LWE
Sbjct: 783  IDFPTSAFDIKFTSPPGDK-FSPRYEFGSLREEDQRKLKDIMQKESLYWLTDADKKRLWE 841

Query: 898  KRYYCFKHPNCLPKILASAPNWKWVNLAKTYSLLHQWPALYPLIALELLDSKFADQEVRS 957
            KRYYC    + LP +LASAP+W+W  L   Y LL QW  +    AL LL + F DQEVR 
Sbjct: 842  KRYYCHSEVSSLPLVLASAPSWEWACLPDIYVLLKQWTHMNHQDALGLLHATFPDQEVRR 901

Query: 958  LAVTWIEAISDDELTDLLPQFVQALKYEIYLNSSLVQFLLSRALGNIQIAHNLYWLLKDA 1017
            +AV WI ++SD EL D LPQ VQALKYE YL+S LV+FLL RA+ ++++ H  +WLLKD 
Sbjct: 902  MAVQWIGSLSDAELLDYLPQLVQALKYECYLDSPLVRFLLKRAVSDLRVTHYFFWLLKDG 961

Query: 1018 LHDVQFSTRYEHVLGALLSVGGKRLREELLKQTKLVQLLGGVAEKVRQASGSARQVVLQR 1077
            L D QFS RY+++L ALL   GK LREE  +Q  LV  L  +A++VR+A+ SARQ +L+ 
Sbjct: 962  LKDSQFSIRYQYLLAALLCCCGKGLREEFNRQCWLVNALAKLAQQVREAAPSARQGILRT 1021

Query: 1078 SMERVQSFFQKN-KCRLPLKPSLVAKELNIKSCSFFSSNAVPLKVTMVNADPMGEEINVM 1136
             +E V+ FF  N  CRLPL PSL+ K +  + CS+F+SNAVPLK++  N DP+GE I V+
Sbjct: 1022 GLEEVKQFFALNGSCRLPLSPSLLVKGIVPRDCSYFNSNAVPLKLSFQNVDPLGENIRVI 1081

Query: 1137 FKVGEDLRQDMLALQMIKIMDKIWLKEGLDLRMVIFKCLSTGRDRGMVELVPASDTLRKI 1196
            FK G+DLRQDML LQMI+IM KIW++EGLD+RMVIF+C STGR RGMVE++P ++TLRKI
Sbjct: 1082 FKCGDDLRQDMLTLQMIRIMSKIWVQEGLDMRMVIFRCFSTGRGRGMVEMIPNAETLRKI 1141

Query: 1197 QVEYGVTGSFKDKPLAEWLRKYNPSEEEYEKASENFIYSCAGCCVATYVLGICDRHNDNI 1256
            QVE+GVTGSFKD+PLA+WL+K+NP E+EYEKA ENFIYSCAGCCVATYVLGICDRHNDNI
Sbjct: 1142 QVEHGVTGSFKDRPLADWLQKHNPGEDEYEKAVENFIYSCAGCCVATYVLGICDRHNDNI 1201

Query: 1257 MLRSTGHMFHIDFGKFLGHAQMFGSFKRDRAPFVLTSDMAYVINGGEKPTIRFQLFVDLC 1316
            ML++TGHMFHIDFG+FLGHAQMFG+ KRDRAPFV TSDMAYVINGG+KP+ RF  FVDLC
Sbjct: 1202 MLKTTGHMFHIDFGRFLGHAQMFGNIKRDRAPFVFTSDMAYVINGGDKPSSRFHDFVDLC 1261

Query: 1317 CQAYNLIRKQTNLFLNLLSLMIPSGLPELTSIQDLKYVRDALQPQTTDAEATIFFTRLIE 1376
            CQAYNLIRK T+LFLNLL LM+  G+PEL+ ++DLKYV DAL+PQ T+A AT +FTRLIE
Sbjct: 1262 CQAYNLIRKHTHLFLNLLGLMLSCGIPELSDLEDLKYVYDALRPQDTEANATTYFTRLIE 1321

Query: 1377 SSLGSIATKFNFFIHNLAQLRFSGLPSNDEPILSFSPKTYSFRQDGRIKEVSVFTYHKKY 1436
            SSLGS+ATK NFFIHNLAQ++F+G  S+D   LSF+ +T++ +  GRI +V +  + K +
Sbjct: 1322 SSLGSVATKLNFFIHNLAQMKFTG--SDDRLTLSFASRTHTLKSSGRISDVFLCRHEKIF 1379

Query: 1437 NPDKHYIYVVRILREGQIEPSFVFRTFDEFQELHNKLSIIFPLWKLPGFPNRMVLGRTHI 1496
            +P+K YIYVV+++RE   E +++ RTF+EFQELHNKL ++FP   LP FP+R V+GR+  
Sbjct: 1380 HPNKGYIYVVKVMRENTHEATYIQRTFEEFQELHNKLRLLFPSSHLPSFPSRFVIGRSRG 1439

Query: 1497 KDVAAKRKIELNSYLQSLMNASTDVAECDLVCTFFHPLLRDEKAEGI--ARSADAGSFSP 1554
            + VA +R+ ELN Y+  L++A  +VAECDLV TFFHPL RDEKA G   A  +  G+++ 
Sbjct: 1440 EAVAERRREELNGYIWHLIHAPPEVAECDLVYTFFHPLPRDEKAMGTSPAPKSSDGTWAR 1499

Query: 1555 TPGQIGGAVKLSISYRNGTLFIMVMHIKDL-VTEDGADPNPYVKTYLLPDNHKTSKRKTK 1613
              G++GG VKLSISY+N  LFIMVMHI+ L + +DG DP+PYVK YLLPD  KT+KRKTK
Sbjct: 1500 PVGKVGGEVKLSISYKNNKLFIMVMHIRGLQLLQDGNDPDPYVKIYLLPDPQKTTKRKTK 1559

Query: 1614 ISRKTRNPTFNEMLVYSGYSKETLRQRELQLSVLSAESLRENFFLGGVTLPLKDFNLSKE 1673
            ++RKT NPT+NEMLVY G  K  L+QRELQLSVLS +   EN  LG V + L++ +L++E
Sbjct: 1560 VARKTCNPTYNEMLVYDGIPKGDLQQRELQLSVLSEQGFWENVLLGEVNIRLRELDLAQE 1619

Query: 1674 TVKWYQLTAATY 1685
               W+ L + ++
Sbjct: 1620 KTGWFALGSRSH 1631


>gi|194353959 phosphoinositide-3-kinase, class 2 gamma polypeptide
            [Homo sapiens]
          Length = 1445

 Score =  735 bits (1898), Expect = 0.0
 Identities = 465/1331 (34%), Positives = 722/1331 (54%), Gaps = 130/1331 (9%)

Query: 363  SLPTGSSLLQEVEVQNEEMAAFCRSITKLKTKFPYTNHRTNPGYLLSPVTAQRNICGENA 422
            S+     L++  +  N  +A+FC  + K++ ++   +   N G + S  TA         
Sbjct: 227  SIGCSIQLVEVPQSSNTSLASFCNKVKKIRERYHAADVNFNSGKIWSTTTAFPYQLFSKT 286

Query: 423  SVKVSIDIEGFQLPVTFTCDVSSTVEIIIMQALCWVHDDLNQVDVGSYVLKVCGQEEVLQ 482
               + I I+    P+ F    +  V+ +I + L +  +D  Q+    ++L VCG EE LQ
Sbjct: 287  KFNIHIFIDNSTQPLHFMPCANYLVKDLIAEILHFCTND--QLLPKDHILSVCGSEEFLQ 344

Query: 483  NNHCLGSHEHIQNCRKWDTEIRLQLLTFSAMCQNLARTAEDDETPVDLNK-----HLYQI 537
            N+HCLGSH+  Q   K  + I+L L         L+R  E+D +   LN+     H++++
Sbjct: 345  NDHCLGSHKMFQ---KDKSVIQLHLQKSREAPGKLSRKHEEDHSQFYLNQLLEFMHIWKV 401

Query: 538  EKPCKEAMTRHPVEELLDSYHNQVELALQIENQHRAVDQVIKAVRKICSALDGVETLAIT 597
             + C   + R         Y   ++  L+ +     V  +I+ V+KICS L  VET  IT
Sbjct: 402  SRQCLLTLIR--------KYDFHLKYLLKTQEN---VYNIIEEVKKICSVLGCVETKQIT 450

Query: 598  ESVKKLKRAVNLPRSKTADVTSLFGGEDTSRSSTRGSLNPENPVQVSINQLTAAIYDLLR 657
            ++V +L  ++ L R           GE+  +SS   +   +  ++    +L+ +IY L+ 
Sbjct: 451  DAVNEL--SLILQRK----------GENFYQSSETSA---KGLIEKVTTELSTSIYQLIN 495

Query: 658  LHANSGRS---PTDCAQSSKSVKEAWTTTEQLQFTIFAAHGISSNWVSNYEKYYLICSLS 714
            ++ NS  +   P +  + +  +     +   L FT++AAH I   WV             
Sbjct: 496  VYCNSFYADFQPVNVPRCTSYLNPGLPS--HLSFTVYAAHNIPETWVHR----------- 542

Query: 715  HNGKDLFKPIQSKKVGTYKNFFYLIKWDELIIFPIQISQLPLESVLHLTLFGILNQSSGS 774
                                          I FP++I  LP ES+L + LFGI   ++ +
Sbjct: 543  ------------------------------INFPLEIKSLPRESMLTVKLFGIACATNNA 572

Query: 775  SPDSNKQRKGPEALGKVSLPLFDFKRFLTCGTKLLYLWTSSHTNSVPGTVTKKGY----V 830
            +            L    LPLF  ++ +  G+ L  +   S     P  +   G      
Sbjct: 573  N-----------LLAWTCLPLFPKEKSIL-GSMLFSMTLQSEP---PVEMITPGVWDVSQ 617

Query: 831  MERIVLQVDFPSPAFDIIYTTPQVDRSIIQQHNLETLENDIKGKLLDILHKDSSLGLSKE 890
               + LQ+DFP+  ++ +    + +RS +++   E +++     +  +  K + L LS+E
Sbjct: 618  PSPVTLQIDFPATGWEYMKPDSEENRSNLEEPLKECIKH-----IARLSQKQTPLLLSEE 672

Query: 891  DKAFLWEKRYYCFKHPNCLPKILASAPNWKWVNLAKTYSLLHQWPALYPLIALELLDSKF 950
             K +LW  R+YC      LP +L SAP W    +++ +++L +W    PL AL LL S F
Sbjct: 673  KKRYLWFYRFYCNNENCSLPLVLGSAPGWDERTVSEMHTILRRWTFSQPLEALGLLTSSF 732

Query: 951  ADQEVRSLAVTWIEAISDDELTDLLPQFVQALKYEIYLNSSLVQFLLSRALGNIQIAHNL 1010
             DQE+R +AV  ++ + +DEL + LPQ VQA+K+E  L S LVQ LL R+L +IQ+AH L
Sbjct: 733  PDQEIRKVAVQQLDNLLNDELLEYLPQLVQAVKFEWNLESPLVQLLLHRSLQSIQVAHRL 792

Query: 1011 YWLLKDALHDVQFSTRYEHVLGALLSVGGKRLREELLKQTKLVQLLGGVAEKVRQASGSA 1070
            YWLLK+A ++  F + Y+ +L AL    GK L +E  K+ KL+++LG + E+V+ AS   
Sbjct: 793  YWLLKNAENEAYFKSWYQKLLAALQFCAGKALNDEFSKEQKLIKILGDIGERVKSASDHQ 852

Query: 1071 RQVVLQRSMERVQSFFQK-NKCRLPLKPSLVAKELNIKSCSFFSSNAVPLKVTMVNADPM 1129
            RQ VL++ + R++ FFQ  N C LPL P+L  K ++  +CS+F+SNA+PLK+T +NA+PM
Sbjct: 853  RQEVLKKEIGRLEEFFQDVNTCHLPLNPALCIKGIDHDACSYFTSNALPLKITFINANPM 912

Query: 1130 GEEINVMFKVGEDLRQDMLALQMIKIMDKIWLKEGLDLRMVIFKCLSTGRDRGMVELVPA 1189
            G+ I+++FK G+DLRQDML LQ+I++MD IWL+EGLD++M+I++CLSTG+D+G+V++VP 
Sbjct: 913  GKNISIIFKAGDDLRQDMLVLQLIQVMDNIWLQEGLDMQMIIYRCLSTGKDQGLVQMVPD 972

Query: 1190 SDTLRKIQVEYGVTGSFKDKPLAEWLRKYNPSEEEYEKASENFIYSCAGCCVATYVLGIC 1249
            + TL KI    G+ G  K+  + +W  ++N  + +YEKA  NF YSCAG CV T++LG+C
Sbjct: 973  AVTLAKIHRHSGLIGPLKENTIKKWFSQHNHLKADYEKALRNFFYSCAGWCVVTFILGVC 1032

Query: 1250 DRHNDNIMLRSTGHMFHIDFGKFLGHAQMFGSFKRDRAPFVLTSDMAYVINGGEKPTIRF 1309
            DRHNDNIML  +GHMFHIDFGKFLGHAQ FG  KRDRAPF+ TS+M Y I  G K    F
Sbjct: 1033 DRHNDNIMLTKSGHMFHIDFGKFLGHAQTFGGIKRDRAPFIFTSEMEYFITEGGKNPQHF 1092

Query: 1310 QLFVDLCCQAYNLIRKQTNLFLNLLSLMIPSGLPELTSIQDLKYVRDALQPQTTDAEATI 1369
            Q FV+LCC+AYN+IRK + L LNLL +M+ +GLPEL+ IQDLKYV + L+PQ TD EAT 
Sbjct: 1093 QDFVELCCRAYNIIRKHSQLLLNLLEMMLYAGLPELSGIQDLKYVYNNLRPQDTDLEATS 1152

Query: 1370 FFTRLIESSLGSIATKFNFFIHNLAQLRFSGLPSNDEPILSFSPKTYSFRQDGRIKEVSV 1429
             FT+ I+ SL     K N  IH LAQ+  S +        +F  ++        I+  ++
Sbjct: 1153 HFTKKIKESLECFPVKLNNLIHTLAQM--SAISPAKSTSQTFPQESCLLSTTRSIERATI 1210

Query: 1430 FTYHKKYNPDKHYIYVVRILREGQIEPSFVFRTFDEFQELHNKLSIIFPLWKLPGFPNRM 1489
              + KK       +Y++++      E S   ++F++F +LH++L   F    LP FP+  
Sbjct: 1211 LGFSKK----SSNLYLIQVTHSNN-ETSLTEKSFEQFSKLHSQLQKQFASLTLPEFPHWW 1265

Query: 1490 VLGRTHIKDVAAKRKIELNSYLQSLMNASTDVAECDLVCTFFHPLLRDEKAEGIARSADA 1549
             L  T+      +R  +LN Y++ ++N S +V   D V +FF   L +   + +  S+  
Sbjct: 1266 HLPFTNSDH---RRFRDLNHYMEQILNVSHEVTNSDCVLSFF---LSEAVQQTVEESSPV 1319

Query: 1550 GSFSPTPGQIGGAVKLSISYRNGTLFIMVMHIKDLVTEDGADPNPYVKTYLLPDNHKTSK 1609
                  P +    V+L ISY +  L I+V H+K++   DG+ P+ +V+ YLLP   +  +
Sbjct: 1320 YLGEKFPDK-KPKVQLVISYEDVKLTILVKHMKNIHLPDGSAPSAHVEFYLLPYPSEVRR 1378

Query: 1610 RKTKISRKTRNPTFNEMLVYSGYSKETLRQRELQLSVLSAESLRENFFLGGVTLPLKDFN 1669
            RKTK   K  +PT+NE++VY   +       ELQ  VL      +  F+G + + L    
Sbjct: 1379 RKTKSVPKCTDPTYNEIVVYDEVT-------ELQGHVLMLIVKSKTVFVGAINIRLCSVP 1431

Query: 1670 LSKETVKWYQL 1680
            L KE  KWY L
Sbjct: 1432 LDKE--KWYPL 1440


>gi|21237725 phosphoinositide-3-kinase, catalytic, gamma polypeptide
            [Homo sapiens]
          Length = 1102

 Score =  388 bits (997), Expect = e-107
 Identities = 247/693 (35%), Positives = 386/693 (55%), Gaps = 39/693 (5%)

Query: 733  KNFFYLIKWDELIIFPIQISQLPLESVLHLTLF-----GILNQSSGSSPDSNKQRKGPEA 787
            K F   + W+  + F I+I  LP  ++L+L ++      + +++S  SP S  + K  + 
Sbjct: 402  KPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGK-VQL 460

Query: 788  LGKVSLPLFDFKRFLTCGTKLLYLWTSSHTNSVPG----------TVTKKGYVMERIVLQ 837
            L  V+L L D +  L  G  +L++W  S      G          T   K   M   +L 
Sbjct: 461  LYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILL 520

Query: 838  VDFPSP-AFDIIYTTPQVDRSIIQQHNLETLENDIKGKLLDILHKDSSLGLSKEDKAFLW 896
             ++  P A      TP  +   ++      + N ++ +L  I+  D    L+ EDK  LW
Sbjct: 521  DNYCHPIALPKHQPTPDPEGDRVRAE----MPNQLRKQLEAIIATDPLNPLTAEDKELLW 576

Query: 897  EKRYYCFKHPNCLPKILASAPNWKWVNLAKTYSLLHQ---WP--ALYPLIALELLDSKFA 951
              RY   KHP   PK+ +S    +   +AKTY LL +   W   AL   + ++LLD  F+
Sbjct: 577  HFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFS 636

Query: 952  DQEVRSLAVTWIEAISDDELTDLLPQFVQALKYEIYLNSSLVQFLLSRALGNIQIAHNLY 1011
            D+ VR++AV  +E++ DD++   L Q VQA+K+E Y +S+L +FLL R L N +I H L+
Sbjct: 637  DENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLF 696

Query: 1012 WLLKDALHDVQ-FSTRYEHVLGALLSVGGKRLREELLKQTKLVQLLGGVAEKVRQASGS- 1069
            W L+  +   + +  R+  +L A L   G  +  +  +Q +++++L  V   ++  S   
Sbjct: 697  WFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEK 756

Query: 1070 ---ARQVV--LQRSMERVQSFFQKNKCRLPLKPSLVAKELNIKSCSFFSSNAVPLKVTMV 1124
               + QV+  L++ +E +Q+       R+P  P L A  L I+ C   +S   PL +   
Sbjct: 757  YDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFK 816

Query: 1125 NADPMG---EEINVMFKVGEDLRQDMLALQMIKIMDKIWLKEGLDLRMVIFKCLSTGRDR 1181
             ADP     E I ++FK G+DLRQDML LQ+++IM+ IW  E LDL ++ + C+STG   
Sbjct: 817  CADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKI 876

Query: 1182 GMVELVPASDTLRKIQVE-YGVTGSFKDKPLAEWLRKYNPSEEEYEKASENFIYSCAGCC 1240
            GM+E+V  + T+ KIQ    G TG+FKD+ L  WL++ +P+EE+++ A E F+YSCAG C
Sbjct: 877  GMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYC 936

Query: 1241 VATYVLGICDRHNDNIMLRSTGHMFHIDFGKFLGHAQMFGSFKRDRAPFVLTSDMAYVI- 1299
            VAT+VLGI DRHNDNIM+  TG++FHIDFG  LG+ + F    ++R PFVLT D  +V+ 
Sbjct: 937  VATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMG 996

Query: 1300 NGGEKPTIRFQLFVDLCCQAYNLIRKQTNLFLNLLSLMIPSGLPELTSIQDLKYVRDALQ 1359
              G+K +  FQ F D+C +AY  +R  TNL + L S+M+ +G+P+LTS +D++Y+RDAL 
Sbjct: 997  TSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALT 1056

Query: 1360 PQTTDAEATIFFTRLIESSLGSIAT-KFNFFIH 1391
                + +A  +F   IE       T +FN+F+H
Sbjct: 1057 VGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLH 1089


>gi|54792082 phosphoinositide-3-kinase, catalytic, alpha polypeptide
            [Homo sapiens]
          Length = 1068

 Score =  375 bits (962), Expect = e-103
 Identities = 257/765 (33%), Positives = 388/765 (50%), Gaps = 67/765 (8%)

Query: 675  SVKEAWTTTEQLQFTIFAAHGISSNWVSNYEKYYLICSLSHNGKDLFKPIQSKKVGTYKN 734
            S K  W     L+  I  A  ++ N + + +K Y+   + H G+ L   + +++V     
Sbjct: 323  STKSLWVINSALRIKILCATYVNVN-IRDIDKIYVRTGIYHGGEPLCDNVNTQRVPCSNP 381

Query: 735  FFYLIKWDELIIFPIQISQLPLESVLHLTLFGILNQSSGSSPDSNKQRKGPEALGKVSLP 794
                 +W+E + + I I  LP  + L L++  +  +         K+   P A G ++L 
Sbjct: 382  -----RWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGA------KEEHCPLAWGNINL- 429

Query: 795  LFDFKRFLTCGTKLLYLWTSSHTNSV---PGTVTKKGYVMERIVLQVDFPSPAFDIIYTT 851
             FD+   L  G   L LW   H       P  VT      E   L+++F    F  +   
Sbjct: 430  -FDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDW--FSSVVKF 486

Query: 852  PQVDRSIIQQH------------------------NLETLENDIKGKLLDILHKDSSLGL 887
            P  D S+I++H                        + E  END K +L  I  +D    +
Sbjct: 487  P--DMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELREND-KEQLKAISTRDPLSEI 543

Query: 888  SKEDKAFLWEKRYYCFKHPNCLPKILASAPNWKWVN---LAKTYSLLHQWPALYPLIALE 944
            ++++K FLW  R+YC   P  LPK+L S    KW +   +A+ Y L+  WP + P  A+E
Sbjct: 544  TEQEKDFLWSHRHYCVTIPEILPKLLLSV---KWNSRDEVAQMYCLVKDWPPIKPEQAME 600

Query: 945  LLDSKFADQEVRSLAVTWIEA-ISDDELTDLLPQFVQALKYEIYLNSSLVQFLLSRALGN 1003
            LLD  + D  VR  AV  +E  ++DD+L+  L Q VQ LKYE YL++ LV+FLL +AL N
Sbjct: 601  LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN 660

Query: 1004 IQIAHNLYWLLKDALHDVQFSTRYEHVLGALLSVGG---KRLREELLKQTKLVQLLGGVA 1060
             +I H  +W LK  +H+   S R+  +L +     G   K L  ++    KL+ L   + 
Sbjct: 661  QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK 720

Query: 1061 EKVRQASGSARQVVLQRSMERVQSFFQKNKCRLPLKPSLVAKELNIKSCSFFSSNAVPLK 1120
            ++ +  +   +   L   M R            PL P+     L ++ C   SS   PL 
Sbjct: 721  QEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW 780

Query: 1121 VTMVNADPMGEEI----NVMFKVGEDLRQDMLALQMIKIMDKIWLKEGLDLRMVIFKCLS 1176
            +   N D M E +     ++FK G+DLRQDML LQ+I+IM+ IW  +GLDLRM+ + CLS
Sbjct: 781  LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS 840

Query: 1177 TGRDRGMVELVPASDTLRKIQVEYGVTGS--FKDKPLAEWLRKYNPSEEEYEKASENFIY 1234
             G   G++E+V  S T+ +IQ + G+ G+  F    L +WL+  N  E  Y+ A + F  
Sbjct: 841  IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEI-YDAAIDLFTR 899

Query: 1235 SCAGCCVATYVLGICDRHNDNIMLRSTGHMFHIDFGKFLGHAQMFGSFKRDRAPFVLTSD 1294
            SCAG CVAT++LGI DRHN NIM++  G +FHIDFG FL H +    +KR+R PFVLT D
Sbjct: 900  SCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQD 959

Query: 1295 MAYVINGGEK---PTIRFQLFVDLCCQAYNLIRKQTNLFLNLLSLMIPSGLPELTSIQDL 1351
               VI+ G +    T  F+ F ++C +AY  IR+  NLF+NL S+M+ SG+PEL S  D+
Sbjct: 960  FLIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDI 1019

Query: 1352 KYVRDALQPQTTDAEATIFFTR-LIESSLGSIATKFNFFIHNLAQ 1395
             Y+R  L    T+ EA  +F + + ++  G   TK ++  H + Q
Sbjct: 1020 AYIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQ 1064


>gi|156564405 catalytic phosphatidylinositol 3-kinase delta [Homo
            sapiens]
          Length = 1044

 Score =  363 bits (932), Expect = e-100
 Identities = 240/708 (33%), Positives = 372/708 (52%), Gaps = 25/708 (3%)

Query: 706  KYYLICSLSHNGKDLFKPIQSKKVGTYKNFFYLIKWDELIIFPIQISQLPLESVLHLTLF 765
            K  +   L H  + L K + S +V           W + + F I I  LP  + L   L+
Sbjct: 340  KLVVQAGLFHGNEMLCKTVSSSEVSVCSEPV----WKQRLEFDINICDLPRMARLCFALY 395

Query: 766  GILNQSSGSSPDSNKQRKGPEALGKVSLPLFDFKRFLTCGTKLLYLWTS-----SHTNSV 820
             ++ ++  +     K +K    +   +L LFD+K  L  G + LY+W S         + 
Sbjct: 396  AVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNP 455

Query: 821  PGTVTKKGYVMERIVLQVDFPSPAFDIIYTTPQVDRSIIQQHNLETLE--NDIKGKLLDI 878
             GTV           L +  P  A   +Y  P +++ +    + E +    + + +L +I
Sbjct: 456  TGTVRSNPNTDSAAALLICLPEVAPHPVYY-PALEKILELGRHSECVHVTEEEQLQLREI 514

Query: 879  LHKDSSLGLSKEDKAFLWEKRYYCFKH-PNCLPKILASAPNWKWVNLAKTYSLLHQWPAL 937
            L +  S  L + +K  +W+ R+   +H P  L ++L      K  ++A+   LL  WP L
Sbjct: 515  LERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPEL 574

Query: 938  YPLIALELLDSKFADQEVRSLAVTWIEAISDDELTDLLPQFVQALKYEIYLNSSLVQFLL 997
              L ALELLD  F D  V S A+  +  ++DDEL   L Q VQ LKYE YL+  L +FLL
Sbjct: 575  PVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLL 634

Query: 998  SRALGNIQIAHNLYWLLKDALHDVQFSTRYEHVLGALLSVGGKRLREELLKQTKLVQLLG 1057
             RAL N +I H L+W L+  +H    + R+  +L A    G     + L+KQ + +  L 
Sbjct: 635  DRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCR-GSTHHMKVLMKQGEALSKLK 693

Query: 1058 GVAEKVRQASGSARQVVLQRSME---RVQSFFQK-NKCRLPLKPSLVAKELNIKSCSFFS 1113
             + + V+ +S    +   +  M    R +++ +  +  + PL PS +  E+ ++ C+F  
Sbjct: 694  ALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMD 753

Query: 1114 SNAVPLKVTMVNADP-MGEEINVMFKVGEDLRQDMLALQMIKIMDKIWLKEGLDLRMVIF 1172
            S   PL +   N +   G  + ++FK G+DLRQDML LQMI++MD +W +EGLDLRM  +
Sbjct: 754  SKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPY 813

Query: 1173 KCLSTGRDRGMVELVPASDTLRKIQVE---YGVTGSFKDKPLAEWLRKYNPSEEEYEKAS 1229
             CL TG   G++E+V  SDT+  IQ+       T +F    L  WL+  NP E   ++A 
Sbjct: 814  GCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEA-LDRAI 872

Query: 1230 ENFIYSCAGCCVATYVLGICDRHNDNIMLRSTGHMFHIDFGKFLGHAQMFGSFKRDRAPF 1289
            E F  SCAG CVATYVLGI DRH+DNIM+R +G +FHIDFG FLG+ +      R+R PF
Sbjct: 873  EEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPF 932

Query: 1290 VLTSDMAYVINGGE-KPTIRFQLFVDLCCQAYNLIRKQTNLFLNLLSLMIPSGLPELTSI 1348
            +LT D  +VI  G+   + +F+ F   C +AY ++R+   LFL+L +LM  +GLPEL+  
Sbjct: 933  ILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCS 992

Query: 1349 QDLKYVRDALQPQTTDAEATIFF-TRLIESSLGSIATKFNFFIHNLAQ 1395
            +D++Y++D+L    T+ EA   F  +  E+   S  TK N+  HN+++
Sbjct: 993  KDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSK 1040


>gi|5453894 catalytic phosphatidylinositol 3-kinase beta [Homo
            sapiens]
          Length = 1070

 Score =  360 bits (924), Expect = 6e-99
 Identities = 259/775 (33%), Positives = 399/775 (51%), Gaps = 53/775 (6%)

Query: 658  LHANSGRSPTDCA-QSSKSVKEAWTTTEQLQFTIFAAHGISSNWVSNYEKYYLICSLSHN 716
            ++ NS   P     + ++ +   W      Q  +   + +++       K ++   L H 
Sbjct: 304  INRNSSNLPLPLPPKKTRIISHVWENNNPFQIVLVKGNKLNTE---ETVKVHVRAGLFHG 360

Query: 717  GKDLFKPIQSKKVGTYKNFFYLIKWDELIIFPIQISQLPLESVLHLTLFGILNQ----SS 772
             + L K I S +V    +      W+E + F I I  LP  + L   ++ +L++     S
Sbjct: 361  TELLCKTIVSSEVSGKNDHI----WNEPLEFDINICDLPRMARLCFAVYAVLDKVKTKKS 416

Query: 773  GSSPDSNKQRKGPEALGKVSLPL-------FDFKRFLTCGTKLLYLWTS-----SHTNSV 820
              + + +K +   +A GKV  P+       FDFK  L  G  +L+ W+S         + 
Sbjct: 417  TKTINPSKYQTIRKA-GKVHYPVAWVNTMVFDFKGQLRTGDIILHSWSSFPDELEEMLNP 475

Query: 821  PGTVTKKGYVMERIVLQVDFPSPAFDIIYTTPQVDRSIIQQHNLETLEN----DIKGK-- 874
             GTV    Y      L V FP       Y  P  D+ I +   + + ++       GK  
Sbjct: 476  MGTVQTNPYTENATALHVKFPENKKQPYYYPP-FDKIIEKAAEIASSDSANVSSRGGKKF 534

Query: 875  ---LLDILHKDSSLGLSKEDKAFLWEKRYYCFK-HPNCLPKILASAPNWKWVNLAKTYSL 930
               L +IL +D    L + +   +W  R  C +  P  LPK+L S    K  ++A+  +L
Sbjct: 535  LPVLKEILDRDPLSQLCENEMDLIWTLRQDCREIFPQSLPKLLLSIKWNKLEDVAQLQAL 594

Query: 931  LHQWPALYPLIALELLDSKFADQEVRSLAVTWIEAISDDELTDLLPQFVQALKYEIYLNS 990
            L  WP L P  ALELLD  + DQ VR  AV  +  +SD+EL+  L Q VQ LKYE +L+ 
Sbjct: 595  LQIWPKLPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDC 654

Query: 991  SLVQFLLSRALGNIQIAHNLYWLLKDALHDVQFSTRYEHVLGALL--SVGGKRLR----E 1044
            +L +FLL RALGN +I   L+W L+  +H    S ++  +L A    SVG  ++     E
Sbjct: 655  ALSRFLLERALGNRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKVLSKQVE 714

Query: 1045 ELLKQTKLVQLLGGVAEKVRQASG-SARQVVLQRSMERVQSFFQKNKCRLPLKPSLVAKE 1103
             L K   L  L+   A K+ +A G  A    L++S  R       +  + PL P ++  E
Sbjct: 715  ALNKLKTLNSLIKLNAVKLNRAKGKEAMHTCLKQSAYRE----ALSDLQSPLNPCVILSE 770

Query: 1104 LNIKSCSFFSSNAVPLKVTMVNADPMGEEINVMFKVGEDLRQDMLALQMIKIMDKIWLKE 1163
            L ++ C +  S   PL +   N     + + V+FK G+DLRQDML LQM+++MD +W + 
Sbjct: 771  LYVEKCKYMDSKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEA 830

Query: 1164 GLDLRMVIFKCLSTGRDRGMVELVPASDTLRKIQV---EYGVTGSFKDKPLAEWLRKYNP 1220
            GLDLRM+ + CL+TG   G++E+V  S+T+  IQ+         +F    L  WL++YN 
Sbjct: 831  GLDLRMLPYGCLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYN- 889

Query: 1221 SEEEYEKASENFIYSCAGCCVATYVLGICDRHNDNIMLRSTGHMFHIDFGKFLGHAQMFG 1280
            S ++ ++A E F  SCAG CVA+YVLGI DRH+DNIM++ TG +FHIDFG  LG+ +   
Sbjct: 890  SGDDLDRAIEEFTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKF 949

Query: 1281 SFKRDRAPFVLTSDMAYVINGGEK-PTIRFQLFVDLCCQAYNLIRKQTNLFLNLLSLMIP 1339
              KR+R PF+LT D  +VI  G+   T +F  F   C  AY ++R+  NLF+ L +LM+ 
Sbjct: 950  GIKRERVPFILTYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLT 1009

Query: 1340 SGLPELTSIQDLKYVRDALQPQTTDAEATIFFTRLIESSL-GSIATKFNFFIHNL 1393
            +GLPELTS++D++Y++D+L    ++ EA   F +  + +L  S  TK N+  H +
Sbjct: 1010 AGLPELTSVKDIQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTV 1064


>gi|34761064 catalytic phosphatidylinositol 3-kinase 3 [Homo sapiens]
          Length = 887

 Score =  173 bits (438), Expect = 1e-42
 Identities = 131/437 (29%), Positives = 208/437 (47%), Gaps = 53/437 (12%)

Query: 988  LNSSLVQFLLSRALGNIQIAHNLYWLLKDALHDVQFSTRYEHVLGALLSVGGKRLREELL 1047
            L   L  FL+SRA  N  +A+ LYW +     D     R        L+V  +R  + LL
Sbjct: 471  LEQDLCTFLISRACKNSTLANYLYWYVIVECEDQDTQQRDPKTHEMYLNVM-RRFSQALL 529

Query: 1048 KQTKLVQLLGGVA--------------EKVRQASGSARQVVLQRSMERVQSFFQKNK--- 1090
            K  K V+++  +               + V++ SG+ +     +  ER+Q+    N+   
Sbjct: 530  KGDKSVRVMRSLLAAQQTFVDRLVHLMKAVQRESGNRK-----KKNERLQALLGDNEKMN 584

Query: 1091 ------CRLPLKPSLVAKELNIKSCSFFSSNAVPLKVTMVNADPMGEEINVMFKVGEDLR 1144
                    LPL+P +  + +  ++ + F S  +P ++     D  G +  V+FK G+DLR
Sbjct: 585  LSDVELIPLPLEPQVKIRGIIPETATLFKSALMPAQLFFKTED--GGKYPVIFKHGDDLR 642

Query: 1145 QDMLALQMIKIMDKIWLKEGLDLRMVIFKCLSTGRDRGMVELVPASDTLRKIQVEYGVTG 1204
            QD L LQ+I +MDK+  KE LDL++  +K L+T    G ++ + +      +  E  +  
Sbjct: 643  QDQLILQIISLMDKLLRKENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEVLDTEGSIQN 702

Query: 1205 SFKDKPLAEWLRKYNPSEEEYEKAS----ENFIYSCAGCCVATYVLGICDRHNDNIMLRS 1260
             F         RKY PSE      S    + ++ SCAG CV TY+LG+ DRH DN++L  
Sbjct: 703  FF---------RKYAPSENGPNGISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLLLTK 753

Query: 1261 TGHMFHIDFGKFLGHAQMFGSFKRDRAPFVLTSDMAYVINGGEKPTIRFQLFVDLCCQAY 1320
            TG +FHIDFG  LG        K    P  L  +M   + G +    ++Q F   C  A+
Sbjct: 754  TGKLFHIDFGYILGRDP-----KPLPPPMKLNKEMVEGMGGTQSE--QYQEFRKQCYTAF 806

Query: 1321 NLIRKQTNLFLNLLSLMIPSGLPELTSIQD--LKYVRDALQPQTTDAEATIFFTRLIESS 1378
              +R+ +NL LNL SLM+ + +P++    D  +K V+D  +   +D EA  +   LI+ S
Sbjct: 807  LHLRRYSNLILNLFSLMVDANIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQSLIDES 866

Query: 1379 LGSIATKFNFFIHNLAQ 1395
            + ++       IH  AQ
Sbjct: 867  VHALFAAVVEQIHKFAQ 883



 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 36/100 (36%), Positives = 49/100 (49%), Gaps = 2/100 (2%)

Query: 887 LSKEDKAFLWEKRYYCFKHPNCLPKILASAPNWKWVNLAK-TYSLLHQWPALYPLIALEL 945
           L+ E++  +W+ RYY       L K L    NW     AK    LL +W  +    +LEL
Sbjct: 308 LTYEEQDLVWKFRYYLTNQEKALTKFLKCV-NWDLPQEAKQALELLGKWKPMDVEDSLEL 366

Query: 946 LDSKFADQEVRSLAVTWIEAISDDELTDLLPQFVQALKYE 985
           L S + +  VR  AV  +    D++L   L Q VQALKYE
Sbjct: 367 LSSHYTNPTVRRYAVARLRQADDEDLLMYLLQLVQALKYE 406



 Score = 32.3 bits (72), Expect = 4.0
 Identities = 16/60 (26%), Positives = 31/60 (51%), Gaps = 4/60 (6%)

Query: 708 YLICSLSHNGKDLFKPIQSKKVGTYKNFFYLIKWDELIIFPIQISQLPLESVLHLTLFGI 767
           Y+ C +   GK L  P+++    +YK F     W+E +  P++   LP  + + LT++ +
Sbjct: 58  YVTCQVFAEGKPLALPVRT----SYKAFSTRWNWNEWLKLPVKYPDLPRNAQVALTIWDV 113


>gi|4505807 phosphatidylinositol 4-kinase type 3 alpha isoform 1 [Homo
            sapiens]
          Length = 854

 Score =  127 bits (320), Expect = 7e-29
 Identities = 121/486 (24%), Positives = 216/486 (44%), Gaps = 59/486 (12%)

Query: 934  WPALYPLIALELLDSKFADQEVRS-LAVTWIEAISDDELTDLLPQFVQALKYEIYLNSSL 992
            W    P   L    S +    + +   V  + +   D +   +PQ VQAL+Y+      +
Sbjct: 364  WAPTDPPTGLSYFSSMYPPHPLTAQYGVKVLRSFPPDAILFYIPQIVQALRYDKM--GYV 421

Query: 993  VQFLLSRALGNIQIAHNLYWLLKDALHDVQFSTRYEHVLGALLSVGGKRLREELLKQTK- 1051
             +++L  A  +  +AH   W +K  ++  +   + +  +G LL    + +   L    K 
Sbjct: 422  REYILWAASKSQLLAHQFIWNMKTNIYLDEEGHQKDPDIGDLLDQLVEEITGSLSGPAKD 481

Query: 1052 LVQLLGGVAEKVRQAS--------GSARQVVLQRSMERVQSFFQKNKCRLPLKPSLVAKE 1103
              Q       K+   S        G  R+     ++  V+    +  C LP  P  +  +
Sbjct: 482  FYQREFDFFNKITNVSAIIKPYPKGDERKKACLSALSEVKV---QPGCYLPSNPEAIVLD 538

Query: 1104 LNIKSCSFFSSNA-----VPLKVTMVNADPM---------------------GEEIN--- 1134
            ++ KS +   S A        KV       +                     G++I+   
Sbjct: 539  IDYKSGTPMQSAAKAPYLAKFKVKRCGVSELEKEGLRCRSDSEDECSTQEADGQKISWQA 598

Query: 1135 VMFKVGEDLRQDMLALQMIKIMDKIWLKEGLDLRMVIFKCLSTGRDRGMVELVPASDTLR 1194
             +FKVG+D RQDMLALQ+I +   I+   GLDL +  ++ ++T    G++E +P   +  
Sbjct: 599  AIFKVGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRD 658

Query: 1195 KI--QVEYGVTGSFKDKPLAEWLRKY-NPSEEEYEKASENFIYSCAGCCVATYVLGICDR 1251
            ++  Q ++G+   F         R+Y + S   +++A  NFI S A   +  ++L I DR
Sbjct: 659  QLGRQTDFGMYDYFT--------RQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDR 710

Query: 1252 HNDNIMLRSTGHMFHIDFGKFLGHAQMFGSFKRDRAPFVLTSDMAYVINGGEKPTIRFQL 1311
            HN NIML   GH+ HIDFG F+  +   G+   +  P +  +D   +I GG+     F+ 
Sbjct: 711  HNGNIMLDKKGHIIHIDFG-FMFESSPGGNLGWE--PDIKLTDEMVMIMGGKMEATPFKW 767

Query: 1312 FVDLCCQAYNLIRKQTNLFLNLLSLMIPSGLPELTSIQDLKYVRDALQPQTTDAEATIFF 1371
            F+++C + Y  +R   +  ++L++LM+ +GLP     Q +K ++    P  T+ EA  F 
Sbjct: 768  FMEMCVRGYLAVRPYMDAVVSLVTLMLDTGLPCFRG-QTIKLLKHRFSPNMTEREAANFI 826

Query: 1372 TRLIES 1377
             ++I+S
Sbjct: 827  MKVIQS 832


>gi|155030226 phosphatidylinositol 4-kinase type 3 alpha isoform 2
            [Homo sapiens]
          Length = 2044

 Score =  127 bits (320), Expect = 7e-29
 Identities = 121/486 (24%), Positives = 216/486 (44%), Gaps = 59/486 (12%)

Query: 934  WPALYPLIALELLDSKFADQEVRS-LAVTWIEAISDDELTDLLPQFVQALKYEIYLNSSL 992
            W    P   L    S +    + +   V  + +   D +   +PQ VQAL+Y+      +
Sbjct: 1554 WAPTDPPTGLSYFSSMYPPHPLTAQYGVKVLRSFPPDAILFYIPQIVQALRYDKM--GYV 1611

Query: 993  VQFLLSRALGNIQIAHNLYWLLKDALHDVQFSTRYEHVLGALLSVGGKRLREELLKQTK- 1051
             +++L  A  +  +AH   W +K  ++  +   + +  +G LL    + +   L    K 
Sbjct: 1612 REYILWAASKSQLLAHQFIWNMKTNIYLDEEGHQKDPDIGDLLDQLVEEITGSLSGPAKD 1671

Query: 1052 LVQLLGGVAEKVRQAS--------GSARQVVLQRSMERVQSFFQKNKCRLPLKPSLVAKE 1103
              Q       K+   S        G  R+     ++  V+    +  C LP  P  +  +
Sbjct: 1672 FYQREFDFFNKITNVSAIIKPYPKGDERKKACLSALSEVKV---QPGCYLPSNPEAIVLD 1728

Query: 1104 LNIKSCSFFSSNA-----VPLKVTMVNADPM---------------------GEEIN--- 1134
            ++ KS +   S A        KV       +                     G++I+   
Sbjct: 1729 IDYKSGTPMQSAAKAPYLAKFKVKRCGVSELEKEGLRCRSDSEDECSTQEADGQKISWQA 1788

Query: 1135 VMFKVGEDLRQDMLALQMIKIMDKIWLKEGLDLRMVIFKCLSTGRDRGMVELVPASDTLR 1194
             +FKVG+D RQDMLALQ+I +   I+   GLDL +  ++ ++T    G++E +P   +  
Sbjct: 1789 AIFKVGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRD 1848

Query: 1195 KI--QVEYGVTGSFKDKPLAEWLRKY-NPSEEEYEKASENFIYSCAGCCVATYVLGICDR 1251
            ++  Q ++G+   F         R+Y + S   +++A  NFI S A   +  ++L I DR
Sbjct: 1849 QLGRQTDFGMYDYFT--------RQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDR 1900

Query: 1252 HNDNIMLRSTGHMFHIDFGKFLGHAQMFGSFKRDRAPFVLTSDMAYVINGGEKPTIRFQL 1311
            HN NIML   GH+ HIDFG F+  +   G+   +  P +  +D   +I GG+     F+ 
Sbjct: 1901 HNGNIMLDKKGHIIHIDFG-FMFESSPGGNLGWE--PDIKLTDEMVMIMGGKMEATPFKW 1957

Query: 1312 FVDLCCQAYNLIRKQTNLFLNLLSLMIPSGLPELTSIQDLKYVRDALQPQTTDAEATIFF 1371
            F+++C + Y  +R   +  ++L++LM+ +GLP     Q +K ++    P  T+ EA  F 
Sbjct: 1958 FMEMCVRGYLAVRPYMDAVVSLVTLMLDTGLPCFRG-QTIKLLKHRFSPNMTEREAANFI 2016

Query: 1372 TRLIES 1377
             ++I+S
Sbjct: 2017 MKVIQS 2022


>gi|4505809 catalytic phosphatidylinositol 4-kinase beta [Homo
            sapiens]
          Length = 828

 Score =  108 bits (269), Expect = 6e-23
 Identities = 71/255 (27%), Positives = 133/255 (52%), Gaps = 12/255 (4%)

Query: 1133 INVMFKVGEDLRQDMLALQMIKIMDKIWLKEGLDLRMVIFKCLSTGRDRGMVELVPASDT 1192
            ++V+ K G+DLRQ++LA Q++K +  IW +E + L +  +K L    D GM+E V  + +
Sbjct: 571  LSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVS 630

Query: 1193 LRKIQVEYGVTGSFKDKPLAEWLRKYNP-SEEEYEKASENFIYSCAGCCVATYVLGICDR 1251
            + +++ +  ++       L  +L+++   + E +  A  NF+ SCAG C+  Y+L + DR
Sbjct: 631  IHQVKKQSQLS------LLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDR 684

Query: 1252 HNDNIMLRSTGHMFHIDFGKFLGHAQMFGSFKRDRAPFVLTSDMAYVINGGEKPTIRFQL 1311
            HN NI+L + GH+ HIDFG  L  +     F  + + F LT++   V+ G +     F  
Sbjct: 685  HNGNILLDAEGHIIHIDFGFILSSSPRNLGF--ETSAFKLTTEFVDVMGGLDGD--MFNY 740

Query: 1312 FVDLCCQAYNLIRKQTNLFLNLLSLMIP-SGLPELTSIQDLKYVRDALQPQTTDAEATIF 1370
            +  L  Q     RK  +  + ++ +M   S LP       ++ +++      T+ +  + 
Sbjct: 741  YKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQLL 800

Query: 1371 FTRLIESSLGSIATK 1385
              ++++ S+ SI TK
Sbjct: 801  VEQMVDGSMRSITTK 815


>gi|239757646 PREDICTED: similar to phosphatidylinositol 4-kinase type
            3 alpha [Homo sapiens]
          Length = 286

 Score = 84.7 bits (208), Expect = 7e-16
 Identities = 51/138 (36%), Positives = 80/138 (57%), Gaps = 11/138 (7%)

Query: 1136 MFKVGEDLRQDMLALQMIKIMDKIWLKEGLDLRMVIFKCLSTGRDRGMVELVPASDTLRK 1195
            +FK+G+D RQDMLALQ+I +   I+   GLDL +  ++ ++T    G++E +P   +  +
Sbjct: 54   IFKLGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQ 113

Query: 1196 I--QVEYGVTGSFKDKPLAEWLRKY-NPSEEEYEKASENFIYSCAGCCVATYVLGICDRH 1252
            +  Q ++G+   F         R+Y + S   +++A  NFI S A   +  ++L I DRH
Sbjct: 114  LGRQTDFGMYDYFT--------RQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRH 165

Query: 1253 NDNIMLRSTGHMFHIDFG 1270
            N NIML   GH+ HIDFG
Sbjct: 166  NGNIMLDKKGHIIHIDFG 183


>gi|15011902 synaptotagmin-like 2 isoform a [Homo sapiens]
          Length = 910

 Score = 81.6 bits (200), Expect = 6e-15
 Identities = 52/159 (32%), Positives = 80/159 (50%), Gaps = 10/159 (6%)

Query: 1533 PLLRDEKAEGIARSADAGSFSPTPGQIGGAVKLSISYRNGT--LFIMVMHIKDLVTEDGA 1590
            P    ++  G   S  +G F     ++ G ++ +I Y      L + V   KDL   D  
Sbjct: 580  PAFLQDEVSGSVMSVYSGDFGNL--EVKGNIQFAIEYVESLKELHVFVAQCKDLAAADVK 637

Query: 1591 DP--NPYVKTYLLPDNHKTSKRKTKISRKTRNPTFNEMLVYSGYSKETLRQRELQLSVLS 1648
                +PYVK YLLPD  K  K+KT + +KT NP +NE+L Y    K+ L+ ++L LS+  
Sbjct: 638  KQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYK-IEKQILKTQKLNLSIWH 696

Query: 1649 AESLRENFFLGGVTLPLKDF---NLSKETVKWYQLTAAT 1684
             ++ + N FLG V L L+ +   N   + ++WY L   T
Sbjct: 697  RDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKT 735



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 41/133 (30%), Positives = 61/133 (45%), Gaps = 12/133 (9%)

Query: 1561 GAVKLSISY-----------RNGTLFIMVMHIKDLVTEDGADPNPYVKTYLLPDNHKTSK 1609
            G +KL++ Y             G + I V    DL    G+  N +VK  +LPD  + S+
Sbjct: 746  GEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSR 805

Query: 1610 RKTKISRKTRNPTFNEMLVYSGYSKETLRQRELQLSVLSAESLRENFFLGGVTLPLKDFN 1669
            +KT+   KT NP FN  +VY G+  E L +  ++L+V     L  N FLGG+ +      
Sbjct: 806  QKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKL-TNQFLGGLRIGFGTGK 864

Query: 1670 LSKETVKWYQLTA 1682
                 V W   T+
Sbjct: 865  SYGTEVDWMDSTS 877


>gi|244790016 synaptotagmin-like 2 isoform h [Homo sapiens]
          Length = 336

 Score = 81.6 bits (200), Expect = 6e-15
 Identities = 52/159 (32%), Positives = 80/159 (50%), Gaps = 10/159 (6%)

Query: 1533 PLLRDEKAEGIARSADAGSFSPTPGQIGGAVKLSISYRNGT--LFIMVMHIKDLVTEDGA 1590
            P    ++  G   S  +G F     ++ G ++ +I Y      L + V   KDL   D  
Sbjct: 6    PAFLQDEVSGSVMSVYSGDFGNL--EVKGNIQFAIEYVESLKELHVFVAQCKDLAAADVK 63

Query: 1591 DP--NPYVKTYLLPDNHKTSKRKTKISRKTRNPTFNEMLVYSGYSKETLRQRELQLSVLS 1648
                +PYVK YLLPD  K  K+KT + +KT NP +NE+L Y    K+ L+ ++L LS+  
Sbjct: 64   KQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYK-IEKQILKTQKLNLSIWH 122

Query: 1649 AESLRENFFLGGVTLPLKDF---NLSKETVKWYQLTAAT 1684
             ++ + N FLG V L L+ +   N   + ++WY L   T
Sbjct: 123  RDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKT 161



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 41/133 (30%), Positives = 61/133 (45%), Gaps = 12/133 (9%)

Query: 1561 GAVKLSISY-----------RNGTLFIMVMHIKDLVTEDGADPNPYVKTYLLPDNHKTSK 1609
            G +KL++ Y             G + I V    DL    G+  N +VK  +LPD  + S+
Sbjct: 172  GEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSR 231

Query: 1610 RKTKISRKTRNPTFNEMLVYSGYSKETLRQRELQLSVLSAESLRENFFLGGVTLPLKDFN 1669
            +KT+   KT NP FN  +VY G+  E L +  ++L+V     L  N FLGG+ +      
Sbjct: 232  QKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKL-TNQFLGGLRIGFGTGK 290

Query: 1670 LSKETVKWYQLTA 1682
                 V W   T+
Sbjct: 291  SYGTEVDWMDSTS 303


>gi|254039650 synaptotagmin-like 5 isoform 1 [Homo sapiens]
          Length = 730

 Score = 79.3 bits (194), Expect = 3e-14
 Identities = 51/127 (40%), Positives = 69/127 (54%), Gaps = 6/127 (4%)

Query: 1558 QIGGAVKLSISY--RNGTLFIMVMHIKDLVTEDGADP--NPYVKTYLLPDNHKTSKRKTK 1613
            ++ G + L ISY  + G L+I V + ++L   D      + YVK+YLLPD  + +KRKTK
Sbjct: 405  KVSGEILLHISYCYKTGGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNNKRKTK 464

Query: 1614 ISRKTRNPTFNEMLVYSGYSKETLRQRELQLSVLSAESLRENFFLGGVTLPLKDFNLSKE 1673
            I R   NP FNE L Y+  S   L  R LQLSV   +    N FLG V +P   +N    
Sbjct: 465  I-RTGTNPEFNETLKYT-ISHTQLETRTLQLSVWHYDRFGRNSFLGEVEIPFDSWNFENP 522

Query: 1674 TVKWYQL 1680
            T +W+ L
Sbjct: 523  TDEWFVL 529



 Score = 64.7 bits (156), Expect = 7e-10
 Identities = 35/104 (33%), Positives = 56/104 (53%), Gaps = 1/104 (0%)

Query: 1561 GAVKLSISYRNGTLFIMVMHIKDLVT-EDGADPNPYVKTYLLPDNHKTSKRKTKISRKTR 1619
            G  K S     G L + +   K+L   + G   + +VK YLLPD+ K +K KT + +K+ 
Sbjct: 576  GKKKESPVISGGILEVFIKEAKNLTAVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSV 635

Query: 1620 NPTFNEMLVYSGYSKETLRQRELQLSVLSAESLRENFFLGGVTL 1663
            NP +N   ++SG   + ++   L+L++   E+   N FLGGV L
Sbjct: 636  NPQWNHTFMFSGIHPQDIKNVCLELTIWDKEAFSSNIFLGGVRL 679


>gi|254039648 synaptotagmin-like 5 isoform 2 [Homo sapiens]
          Length = 752

 Score = 79.3 bits (194), Expect = 3e-14
 Identities = 51/127 (40%), Positives = 69/127 (54%), Gaps = 6/127 (4%)

Query: 1558 QIGGAVKLSISY--RNGTLFIMVMHIKDLVTEDGADP--NPYVKTYLLPDNHKTSKRKTK 1613
            ++ G + L ISY  + G L+I V + ++L   D      + YVK+YLLPD  + +KRKTK
Sbjct: 427  KVSGEILLHISYCYKTGGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNNKRKTK 486

Query: 1614 ISRKTRNPTFNEMLVYSGYSKETLRQRELQLSVLSAESLRENFFLGGVTLPLKDFNLSKE 1673
            I R   NP FNE L Y+  S   L  R LQLSV   +    N FLG V +P   +N    
Sbjct: 487  I-RTGTNPEFNETLKYT-ISHTQLETRTLQLSVWHYDRFGRNSFLGEVEIPFDSWNFENP 544

Query: 1674 TVKWYQL 1680
            T +W+ L
Sbjct: 545  TDEWFVL 551



 Score = 64.7 bits (156), Expect = 7e-10
 Identities = 35/104 (33%), Positives = 56/104 (53%), Gaps = 1/104 (0%)

Query: 1561 GAVKLSISYRNGTLFIMVMHIKDLVT-EDGADPNPYVKTYLLPDNHKTSKRKTKISRKTR 1619
            G  K S     G L + +   K+L   + G   + +VK YLLPD+ K +K KT + +K+ 
Sbjct: 598  GKKKESPVISGGILEVFIKEAKNLTAVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSV 657

Query: 1620 NPTFNEMLVYSGYSKETLRQRELQLSVLSAESLRENFFLGGVTL 1663
            NP +N   ++SG   + ++   L+L++   E+   N FLGGV L
Sbjct: 658  NPQWNHTFMFSGIHPQDIKNVCLELTIWDKEAFSSNIFLGGVRL 701


>gi|20270305 synaptotagmin-like 5 isoform 1 [Homo sapiens]
          Length = 730

 Score = 79.3 bits (194), Expect = 3e-14
 Identities = 51/127 (40%), Positives = 69/127 (54%), Gaps = 6/127 (4%)

Query: 1558 QIGGAVKLSISY--RNGTLFIMVMHIKDLVTEDGADP--NPYVKTYLLPDNHKTSKRKTK 1613
            ++ G + L ISY  + G L+I V + ++L   D      + YVK+YLLPD  + +KRKTK
Sbjct: 405  KVSGEILLHISYCYKTGGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNNKRKTK 464

Query: 1614 ISRKTRNPTFNEMLVYSGYSKETLRQRELQLSVLSAESLRENFFLGGVTLPLKDFNLSKE 1673
            I R   NP FNE L Y+  S   L  R LQLSV   +    N FLG V +P   +N    
Sbjct: 465  I-RTGTNPEFNETLKYT-ISHTQLETRTLQLSVWHYDRFGRNSFLGEVEIPFDSWNFENP 522

Query: 1674 TVKWYQL 1680
            T +W+ L
Sbjct: 523  TDEWFVL 529



 Score = 64.7 bits (156), Expect = 7e-10
 Identities = 35/104 (33%), Positives = 56/104 (53%), Gaps = 1/104 (0%)

Query: 1561 GAVKLSISYRNGTLFIMVMHIKDLVT-EDGADPNPYVKTYLLPDNHKTSKRKTKISRKTR 1619
            G  K S     G L + +   K+L   + G   + +VK YLLPD+ K +K KT + +K+ 
Sbjct: 576  GKKKESPVISGGILEVFIKEAKNLTAVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSV 635

Query: 1620 NPTFNEMLVYSGYSKETLRQRELQLSVLSAESLRENFFLGGVTL 1663
            NP +N   ++SG   + ++   L+L++   E+   N FLGGV L
Sbjct: 636  NPQWNHTFMFSGIHPQDIKNVCLELTIWDKEAFSSNIFLGGVRL 679


>gi|15011900 synaptotagmin-like 2 isoform b [Homo sapiens]
          Length = 376

 Score = 79.0 bits (193), Expect = 4e-14
 Identities = 51/150 (34%), Positives = 77/150 (51%), Gaps = 10/150 (6%)

Query: 1542 GIARSADAGSFSPTPGQIGGAVKLSISYRNGT--LFIMVMHIKDLVTEDGADP--NPYVK 1597
            G   S  +G F     ++ G ++ +I Y      L + V   KDL   D      +PYVK
Sbjct: 55   GSVMSVYSGDFGNL--EVKGNIQFAIEYVESLKELHVFVAQCKDLAAADVKKQRSDPYVK 112

Query: 1598 TYLLPDNHKTSKRKTKISRKTRNPTFNEMLVYSGYSKETLRQRELQLSVLSAESLRENFF 1657
             YLLPD  K  K+KT + +KT NP +NE+L Y    K+ L+ ++L LS+   ++ + N F
Sbjct: 113  AYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYK-IEKQILKTQKLNLSIWHRDTFKRNSF 171

Query: 1658 LGGVTLPLKDF---NLSKETVKWYQLTAAT 1684
            LG V L L+ +   N   + ++WY L   T
Sbjct: 172  LGEVELDLETWDWDNKQNKQLRWYPLKRKT 201



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 41/133 (30%), Positives = 61/133 (45%), Gaps = 12/133 (9%)

Query: 1561 GAVKLSISY-----------RNGTLFIMVMHIKDLVTEDGADPNPYVKTYLLPDNHKTSK 1609
            G +KL++ Y             G + I V    DL    G+  N +VK  +LPD  + S+
Sbjct: 212  GEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSR 271

Query: 1610 RKTKISRKTRNPTFNEMLVYSGYSKETLRQRELQLSVLSAESLRENFFLGGVTLPLKDFN 1669
            +KT+   KT NP FN  +VY G+  E L +  ++L+V     L  N FLGG+ +      
Sbjct: 272  QKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKL-TNQFLGGLRIGFGTGK 330

Query: 1670 LSKETVKWYQLTA 1682
                 V W   T+
Sbjct: 331  SYGTEVDWMDSTS 343


>gi|244790020 synaptotagmin-like 2 isoform i [Homo sapiens]
          Length = 935

 Score = 79.0 bits (193), Expect = 4e-14
 Identities = 51/150 (34%), Positives = 77/150 (51%), Gaps = 10/150 (6%)

Query: 1542 GIARSADAGSFSPTPGQIGGAVKLSISYRNGT--LFIMVMHIKDLVTEDGADP--NPYVK 1597
            G   S  +G F     ++ G ++ +I Y      L + V   KDL   D      +PYVK
Sbjct: 614  GSVMSVYSGDFGNL--EVKGNIQFAIEYVESLKELHVFVAQCKDLAAADVKKQRSDPYVK 671

Query: 1598 TYLLPDNHKTSKRKTKISRKTRNPTFNEMLVYSGYSKETLRQRELQLSVLSAESLRENFF 1657
             YLLPD  K  K+KT + +KT NP +NE+L Y    K+ L+ ++L LS+   ++ + N F
Sbjct: 672  AYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYK-IEKQILKTQKLNLSIWHRDTFKRNSF 730

Query: 1658 LGGVTLPLKDF---NLSKETVKWYQLTAAT 1684
            LG V L L+ +   N   + ++WY L   T
Sbjct: 731  LGEVELDLETWDWDNKQNKQLRWYPLKRKT 760



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 41/133 (30%), Positives = 61/133 (45%), Gaps = 12/133 (9%)

Query: 1561 GAVKLSISY-----------RNGTLFIMVMHIKDLVTEDGADPNPYVKTYLLPDNHKTSK 1609
            G +KL++ Y             G + I V    DL    G+  N +VK  +LPD  + S+
Sbjct: 771  GEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSR 830

Query: 1610 RKTKISRKTRNPTFNEMLVYSGYSKETLRQRELQLSVLSAESLRENFFLGGVTLPLKDFN 1669
            +KT+   KT NP FN  +VY G+  E L +  ++L+V     L  N FLGG+ +      
Sbjct: 831  QKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKL-TNQFLGGLRIGFGTGK 889

Query: 1670 LSKETVKWYQLTA 1682
                 V W   T+
Sbjct: 890  SYGTEVDWMDSTS 902


>gi|244790013 synaptotagmin-like 2 isoform g [Homo sapiens]
          Length = 934

 Score = 79.0 bits (193), Expect = 4e-14
 Identities = 51/150 (34%), Positives = 77/150 (51%), Gaps = 10/150 (6%)

Query: 1542 GIARSADAGSFSPTPGQIGGAVKLSISYRNGT--LFIMVMHIKDLVTEDGADP--NPYVK 1597
            G   S  +G F     ++ G ++ +I Y      L + V   KDL   D      +PYVK
Sbjct: 613  GSVMSVYSGDFGNL--EVKGNIQFAIEYVESLKELHVFVAQCKDLAAADVKKQRSDPYVK 670

Query: 1598 TYLLPDNHKTSKRKTKISRKTRNPTFNEMLVYSGYSKETLRQRELQLSVLSAESLRENFF 1657
             YLLPD  K  K+KT + +KT NP +NE+L Y    K+ L+ ++L LS+   ++ + N F
Sbjct: 671  AYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYK-IEKQILKTQKLNLSIWHRDTFKRNSF 729

Query: 1658 LGGVTLPLKDF---NLSKETVKWYQLTAAT 1684
            LG V L L+ +   N   + ++WY L   T
Sbjct: 730  LGEVELDLETWDWDNKQNKQLRWYPLKRKT 759



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 41/133 (30%), Positives = 61/133 (45%), Gaps = 12/133 (9%)

Query: 1561 GAVKLSISY-----------RNGTLFIMVMHIKDLVTEDGADPNPYVKTYLLPDNHKTSK 1609
            G +KL++ Y             G + I V    DL    G+  N +VK  +LPD  + S+
Sbjct: 770  GEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSR 829

Query: 1610 RKTKISRKTRNPTFNEMLVYSGYSKETLRQRELQLSVLSAESLRENFFLGGVTLPLKDFN 1669
            +KT+   KT NP FN  +VY G+  E L +  ++L+V     L  N FLGG+ +      
Sbjct: 830  QKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKL-TNQFLGGLRIGFGTGK 888

Query: 1670 LSKETVKWYQLTA 1682
                 V W   T+
Sbjct: 889  SYGTEVDWMDSTS 901


>gi|46255068 synaptotagmin-like 2 isoform f [Homo sapiens]
          Length = 365

 Score = 79.0 bits (193), Expect = 4e-14
 Identities = 51/150 (34%), Positives = 77/150 (51%), Gaps = 10/150 (6%)

Query: 1542 GIARSADAGSFSPTPGQIGGAVKLSISYRNGT--LFIMVMHIKDLVTEDGADP--NPYVK 1597
            G   S  +G F     ++ G ++ +I Y      L + V   KDL   D      +PYVK
Sbjct: 44   GSVMSVYSGDFGNL--EVKGNIQFAIEYVESLKELHVFVAQCKDLAAADVKKQRSDPYVK 101

Query: 1598 TYLLPDNHKTSKRKTKISRKTRNPTFNEMLVYSGYSKETLRQRELQLSVLSAESLRENFF 1657
             YLLPD  K  K+KT + +KT NP +NE+L Y    K+ L+ ++L LS+   ++ + N F
Sbjct: 102  AYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYK-IEKQILKTQKLNLSIWHRDTFKRNSF 160

Query: 1658 LGGVTLPLKDF---NLSKETVKWYQLTAAT 1684
            LG V L L+ +   N   + ++WY L   T
Sbjct: 161  LGEVELDLETWDWDNKQNKQLRWYPLKRKT 190



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 41/133 (30%), Positives = 61/133 (45%), Gaps = 12/133 (9%)

Query: 1561 GAVKLSISY-----------RNGTLFIMVMHIKDLVTEDGADPNPYVKTYLLPDNHKTSK 1609
            G +KL++ Y             G + I V    DL    G+  N +VK  +LPD  + S+
Sbjct: 201  GEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSR 260

Query: 1610 RKTKISRKTRNPTFNEMLVYSGYSKETLRQRELQLSVLSAESLRENFFLGGVTLPLKDFN 1669
            +KT+   KT NP FN  +VY G+  E L +  ++L+V     L  N FLGG+ +      
Sbjct: 261  QKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKL-TNQFLGGLRIGFGTGK 319

Query: 1670 LSKETVKWYQLTA 1682
                 V W   T+
Sbjct: 320  SYGTEVDWMDSTS 332


>gi|46255066 synaptotagmin-like 2 isoform e [Homo sapiens]
          Length = 376

 Score = 79.0 bits (193), Expect = 4e-14
 Identities = 51/150 (34%), Positives = 77/150 (51%), Gaps = 10/150 (6%)

Query: 1542 GIARSADAGSFSPTPGQIGGAVKLSISYRNGT--LFIMVMHIKDLVTEDGADP--NPYVK 1597
            G   S  +G F     ++ G ++ +I Y      L + V   KDL   D      +PYVK
Sbjct: 55   GSVMSVYSGDFGNL--EVKGNIQFAIEYVESLKELHVFVAQCKDLAAADVKKQRSDPYVK 112

Query: 1598 TYLLPDNHKTSKRKTKISRKTRNPTFNEMLVYSGYSKETLRQRELQLSVLSAESLRENFF 1657
             YLLPD  K  K+KT + +KT NP +NE+L Y    K+ L+ ++L LS+   ++ + N F
Sbjct: 113  AYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYK-IEKQILKTQKLNLSIWHRDTFKRNSF 171

Query: 1658 LGGVTLPLKDF---NLSKETVKWYQLTAAT 1684
            LG V L L+ +   N   + ++WY L   T
Sbjct: 172  LGEVELDLETWDWDNKQNKQLRWYPLKRKT 201



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 41/133 (30%), Positives = 61/133 (45%), Gaps = 12/133 (9%)

Query: 1561 GAVKLSISY-----------RNGTLFIMVMHIKDLVTEDGADPNPYVKTYLLPDNHKTSK 1609
            G +KL++ Y             G + I V    DL    G+  N +VK  +LPD  + S+
Sbjct: 212  GEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSR 271

Query: 1610 RKTKISRKTRNPTFNEMLVYSGYSKETLRQRELQLSVLSAESLRENFFLGGVTLPLKDFN 1669
            +KT+   KT NP FN  +VY G+  E L +  ++L+V     L  N FLGG+ +      
Sbjct: 272  QKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKL-TNQFLGGLRIGFGTGK 330

Query: 1670 LSKETVKWYQLTA 1682
                 V W   T+
Sbjct: 331  SYGTEVDWMDSTS 343


>gi|46255064 synaptotagmin-like 2 isoform d [Homo sapiens]
          Length = 1256

 Score = 79.0 bits (193), Expect = 4e-14
 Identities = 51/150 (34%), Positives = 77/150 (51%), Gaps = 10/150 (6%)

Query: 1542 GIARSADAGSFSPTPGQIGGAVKLSISYRNGT--LFIMVMHIKDLVTEDGADP--NPYVK 1597
            G   S  +G F     ++ G ++ +I Y      L + V   KDL   D      +PYVK
Sbjct: 935  GSVMSVYSGDFGNL--EVKGNIQFAIEYVESLKELHVFVAQCKDLAAADVKKQRSDPYVK 992

Query: 1598 TYLLPDNHKTSKRKTKISRKTRNPTFNEMLVYSGYSKETLRQRELQLSVLSAESLRENFF 1657
             YLLPD  K  K+KT + +KT NP +NE+L Y    K+ L+ ++L LS+   ++ + N F
Sbjct: 993  AYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYK-IEKQILKTQKLNLSIWHRDTFKRNSF 1051

Query: 1658 LGGVTLPLKDF---NLSKETVKWYQLTAAT 1684
            LG V L L+ +   N   + ++WY L   T
Sbjct: 1052 LGEVELDLETWDWDNKQNKQLRWYPLKRKT 1081



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 41/133 (30%), Positives = 61/133 (45%), Gaps = 12/133 (9%)

Query: 1561 GAVKLSISY-----------RNGTLFIMVMHIKDLVTEDGADPNPYVKTYLLPDNHKTSK 1609
            G +KL++ Y             G + I V    DL    G+  N +VK  +LPD  + S+
Sbjct: 1092 GEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSR 1151

Query: 1610 RKTKISRKTRNPTFNEMLVYSGYSKETLRQRELQLSVLSAESLRENFFLGGVTLPLKDFN 1669
            +KT+   KT NP FN  +VY G+  E L +  ++L+V     L  N FLGG+ +      
Sbjct: 1152 QKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKL-TNQFLGGLRIGFGTGK 1210

Query: 1670 LSKETVKWYQLTA 1682
                 V W   T+
Sbjct: 1211 SYGTEVDWMDSTS 1223


>gi|46255062 synaptotagmin-like 2 isoform c [Homo sapiens]
          Length = 1272

 Score = 79.0 bits (193), Expect = 4e-14
 Identities = 51/150 (34%), Positives = 77/150 (51%), Gaps = 10/150 (6%)

Query: 1542 GIARSADAGSFSPTPGQIGGAVKLSISYRNGT--LFIMVMHIKDLVTEDGADP--NPYVK 1597
            G   S  +G F     ++ G ++ +I Y      L + V   KDL   D      +PYVK
Sbjct: 951  GSVMSVYSGDFGNL--EVKGNIQFAIEYVESLKELHVFVAQCKDLAAADVKKQRSDPYVK 1008

Query: 1598 TYLLPDNHKTSKRKTKISRKTRNPTFNEMLVYSGYSKETLRQRELQLSVLSAESLRENFF 1657
             YLLPD  K  K+KT + +KT NP +NE+L Y    K+ L+ ++L LS+   ++ + N F
Sbjct: 1009 AYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYK-IEKQILKTQKLNLSIWHRDTFKRNSF 1067

Query: 1658 LGGVTLPLKDF---NLSKETVKWYQLTAAT 1684
            LG V L L+ +   N   + ++WY L   T
Sbjct: 1068 LGEVELDLETWDWDNKQNKQLRWYPLKRKT 1097



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 41/133 (30%), Positives = 61/133 (45%), Gaps = 12/133 (9%)

Query: 1561 GAVKLSISY-----------RNGTLFIMVMHIKDLVTEDGADPNPYVKTYLLPDNHKTSK 1609
            G +KL++ Y             G + I V    DL    G+  N +VK  +LPD  + S+
Sbjct: 1108 GEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSR 1167

Query: 1610 RKTKISRKTRNPTFNEMLVYSGYSKETLRQRELQLSVLSAESLRENFFLGGVTLPLKDFN 1669
            +KT+   KT NP FN  +VY G+  E L +  ++L+V     L  N FLGG+ +      
Sbjct: 1168 QKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKL-TNQFLGGLRIGFGTGK 1226

Query: 1670 LSKETVKWYQLTA 1682
                 V W   T+
Sbjct: 1227 SYGTEVDWMDSTS 1239


>gi|193804862 synaptotagmin-like 4 [Homo sapiens]
          Length = 671

 Score = 77.4 bits (189), Expect = 1e-13
 Identities = 50/130 (38%), Positives = 67/130 (51%), Gaps = 3/130 (2%)

Query: 1553 SPTPGQIGGAVKLSISYRNGTLFIMVMHIKDLVT-EDGADPNPYVKTYLLPDNHKTSKRK 1611
            S TP  +GG  K S     G L + +   K+L   + G   + +VK YLLP  +K SKRK
Sbjct: 509  SKTP--VGGDRKKSKGGEGGELQVWIKEAKNLTAAKAGGTSDSFVKGYLLPMRNKASKRK 566

Query: 1612 TKISRKTRNPTFNEMLVYSGYSKETLRQRELQLSVLSAESLRENFFLGGVTLPLKDFNLS 1671
            T + +KT NP +N   VY+G   E L+   L+L+V   E L  N FLGGV L +     +
Sbjct: 567  TPVMKKTLNPHYNHTFVYNGVRLEDLQHMCLELTVWDREPLASNDFLGGVRLGVGTGISN 626

Query: 1672 KETVKWYQLT 1681
             E V W   T
Sbjct: 627  GEVVDWMDST 636



 Score = 69.3 bits (168), Expect = 3e-11
 Identities = 45/120 (37%), Positives = 60/120 (50%), Gaps = 7/120 (5%)

Query: 1559 IGGAVKLSISYRNGTLFIMVMHIKDLVTEDGADP-----NPYVKTYLLPDNHKTSKRKTK 1613
            + G +  S+ Y   T  ++V H+K+      AD      NPYVKTYLLPD  +  KRKT 
Sbjct: 356  VTGRIAFSLKYEQQTQSLVV-HVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTS 414

Query: 1614 ISRKTRNPTFNEMLVYSGYSKETLRQRELQLSVLSAESLRENFFLGGVTLPLKDFNLSKE 1673
            I R T NP ++E L Y    +  L QR LQ SV        N FLG   + +  + L K+
Sbjct: 415  IKRDTINPLYDETLRYE-IPESLLAQRTLQFSVWHHGRFGRNTFLGEAEIQMDSWKLDKK 473


>gi|193804860 synaptotagmin-like 4 [Homo sapiens]
          Length = 671

 Score = 77.4 bits (189), Expect = 1e-13
 Identities = 50/130 (38%), Positives = 67/130 (51%), Gaps = 3/130 (2%)

Query: 1553 SPTPGQIGGAVKLSISYRNGTLFIMVMHIKDLVT-EDGADPNPYVKTYLLPDNHKTSKRK 1611
            S TP  +GG  K S     G L + +   K+L   + G   + +VK YLLP  +K SKRK
Sbjct: 509  SKTP--VGGDRKKSKGGEGGELQVWIKEAKNLTAAKAGGTSDSFVKGYLLPMRNKASKRK 566

Query: 1612 TKISRKTRNPTFNEMLVYSGYSKETLRQRELQLSVLSAESLRENFFLGGVTLPLKDFNLS 1671
            T + +KT NP +N   VY+G   E L+   L+L+V   E L  N FLGGV L +     +
Sbjct: 567  TPVMKKTLNPHYNHTFVYNGVRLEDLQHMCLELTVWDREPLASNDFLGGVRLGVGTGISN 626

Query: 1672 KETVKWYQLT 1681
             E V W   T
Sbjct: 627  GEVVDWMDST 636



 Score = 69.3 bits (168), Expect = 3e-11
 Identities = 45/120 (37%), Positives = 60/120 (50%), Gaps = 7/120 (5%)

Query: 1559 IGGAVKLSISYRNGTLFIMVMHIKDLVTEDGADP-----NPYVKTYLLPDNHKTSKRKTK 1613
            + G +  S+ Y   T  ++V H+K+      AD      NPYVKTYLLPD  +  KRKT 
Sbjct: 356  VTGRIAFSLKYEQQTQSLVV-HVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTS 414

Query: 1614 ISRKTRNPTFNEMLVYSGYSKETLRQRELQLSVLSAESLRENFFLGGVTLPLKDFNLSKE 1673
            I R T NP ++E L Y    +  L QR LQ SV        N FLG   + +  + L K+
Sbjct: 415  IKRDTINPLYDETLRYE-IPESLLAQRTLQFSVWHHGRFGRNTFLGEAEIQMDSWKLDKK 473


>gi|150170670 piccolo isoform 2 [Homo sapiens]
          Length = 4935

 Score = 75.9 bits (185), Expect = 3e-13
 Identities = 48/151 (31%), Positives = 75/151 (49%), Gaps = 16/151 (10%)

Query: 1550 GSFSPTPGQ------IGGAVKLSISYRNGTLFIMVMHIKDLVTEDGAD-PNPYVKTYLLP 1602
            GS  PT G       I G ++L I+Y  G L I ++  ++LV  D     +P+VK YLLP
Sbjct: 4679 GSSKPTDGTKVVSHPITGEIQLQINYDLGNLIIHILQARNLVPRDNNGYSDPFVKVYLLP 4738

Query: 1603 DNHKTS---------KRKTKISRKTRNPTFNEMLVYSGYSKETLRQRELQLSVLSAESLR 1653
               +           KR+TK  +K+ NP +N+ ++Y   S E L+++ L+++V   +   
Sbjct: 4739 GRGQVMVVQNASAEYKRRTKHVQKSLNPEWNQTVIYKSISMEQLKKKTLEVTVWDYDRFS 4798

Query: 1654 ENFFLGGVTLPLKDFNLSKETVKWYQLTAAT 1684
             N FLG V + L   +    T +WY L   T
Sbjct: 4799 SNDFLGEVLIDLSSTSHLDNTPRWYPLKEQT 4829


>gi|150378539 piccolo isoform 1 [Homo sapiens]
          Length = 5142

 Score = 75.9 bits (185), Expect = 3e-13
 Identities = 48/151 (31%), Positives = 75/151 (49%), Gaps = 16/151 (10%)

Query: 1550 GSFSPTPGQ------IGGAVKLSISYRNGTLFIMVMHIKDLVTEDGAD-PNPYVKTYLLP 1602
            GS  PT G       I G ++L I+Y  G L I ++  ++LV  D     +P+VK YLLP
Sbjct: 4679 GSSKPTDGTKVVSHPITGEIQLQINYDLGNLIIHILQARNLVPRDNNGYSDPFVKVYLLP 4738

Query: 1603 DNHKTS---------KRKTKISRKTRNPTFNEMLVYSGYSKETLRQRELQLSVLSAESLR 1653
               +           KR+TK  +K+ NP +N+ ++Y   S E L+++ L+++V   +   
Sbjct: 4739 GRGQVMVVQNASAEYKRRTKHVQKSLNPEWNQTVIYKSISMEQLKKKTLEVTVWDYDRFS 4798

Query: 1654 ENFFLGGVTLPLKDFNLSKETVKWYQLTAAT 1684
             N FLG V + L   +    T +WY L   T
Sbjct: 4799 SNDFLGEVLIDLSSTSHLDNTPRWYPLKEQT 4829



 Score = 39.3 bits (90), Expect = 0.033
 Identities = 35/144 (24%), Positives = 65/144 (45%), Gaps = 18/144 (12%)

Query: 1547 ADAGSFSPTPGQIGGAVKLSISYRNGTLFIMVMHIKDLVTEDGAD---PNPYVKTYLL-- 1601
            AD  + +   G+I  A+K  +      L + ++  +++  +  +    P+ YVK Y++  
Sbjct: 4999 ADTEAKTQVMGEIKIALKKEMKTDGEQLIVEILQCRNITYKFKSPDHLPDLYVKIYVMNI 5058

Query: 1602 PDNHKTSKRKTKISRKTRNPTFNEMLVYS----GYSKETLRQRELQLSVLS-AESLRENF 1656
                K  K+KT++ R  R P+FNE   +S    G+S        LQ+ + S      +  
Sbjct: 5059 STQKKVIKKKTRVCRHDREPSFNETFRFSLSPAGHS--------LQILLFSNGGKFMKKT 5110

Query: 1657 FLGGVTLPLKDFNLSKETVKWYQL 1680
             +G   + L   +L K  V W++L
Sbjct: 5111 LIGEACIWLDKVDLRKRIVNWHKL 5134


>gi|14249614 synaptotagmin-like 1 [Homo sapiens]
          Length = 550

 Score = 75.1 bits (183), Expect = 5e-13
 Identities = 49/118 (41%), Positives = 65/118 (55%), Gaps = 5/118 (4%)

Query: 1558 QIGGAVKLSISYRNGT--LFIMVMHIKDLVTEDGADPNPYVKTYLLPDNHKTSKRKTKIS 1615
            Q+ G+V  ++ Y  G   L + V+  + L        +PYVK+YLLPD  K SKRKT + 
Sbjct: 253  QVRGSVHFALHYEPGAAELRVHVIQCQGLAAARRRRSDPYVKSYLLPD--KQSKRKTAVK 310

Query: 1616 RKTRNPTFNEMLVYSGYSKETLRQRELQLSVLSAESLRENFFLGGVTLPLKDFNLSKE 1673
            ++  NP FNE L YS    E L+ R L LSV   ESL  N FLG V +PL  ++   E
Sbjct: 311  KRNLNPVFNETLRYSVPQAE-LQGRVLSLSVWHRESLGRNIFLGEVEVPLDTWDWGSE 367



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 34/111 (30%), Positives = 57/111 (51%), Gaps = 1/111 (0%)

Query: 1571 NGTLFIMVMHIKDLVTEDGADPNPYVKTYLLPDNHKTSKRKTKISRKTRNPTFNEMLVYS 1630
            +G L   V   +DL+       + YV+ ++LPD+ + S+++T++ R++ +P FN  +VY 
Sbjct: 409  SGELHFWVKEARDLLPLRAGSLDTYVQCFVLPDDSQASRQRTRVVRRSLSPVFNHTMVYD 468

Query: 1631 GYSKETLRQRELQLSVLSAESLRENFFLGGVTLPLKDFNLSKETVKWYQLT 1681
            G+    LRQ   +LS+    +L  N  LGG  L L   +     V W   T
Sbjct: 469  GFGPADLRQACAELSLWDHGAL-ANRQLGGTRLSLGTGSSYGLQVPWMDST 518


>gi|154354981 regulating synaptic membrane exocytosis 2 isoform b
            [Homo sapiens]
          Length = 1163

 Score = 72.4 bits (176), Expect = 3e-12
 Identities = 48/164 (29%), Positives = 78/164 (47%), Gaps = 6/164 (3%)

Query: 1522 AECDLVCTFFHPLLRDEKAEGIARSADAGSFSPTPGQIGG--AVKLSISYRNGTLFIMVM 1579
            A+ +   + F     D  +  +      G     P  + G  ++KL        L + ++
Sbjct: 498  AQLESSSSSFESQKMDRPSISVTSPMSPGMLRDVPQFLSGQLSIKLWFDKVGHQLIVTIL 557

Query: 1580 HIKDLVT-EDGADPNPYVKTYLLPDNHKTSKRKTKISRKTRNPTFNEMLVYSGYSKETLR 1638
              KDL + EDG   NPYVK Y LPD    +KR+TK  +KT  P +N+  +YS   +   R
Sbjct: 558  GAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIYSPVHRREFR 617

Query: 1639 QRELQLSVLSAESLR--ENFFLGGVTLPLKDFNLSKETVKWYQL 1680
            +R L++++     +R  E+ FLG + + L+   L  E   WY+L
Sbjct: 618  ERMLEITLWDQARVREEESEFLGEILIELETALLDDEP-HWYKL 660



 Score = 56.6 bits (135), Expect = 2e-07
 Identities = 34/123 (27%), Positives = 66/123 (53%), Gaps = 7/123 (5%)

Query: 1561 GAVKLSISYRNGTLFIMVMHIKDLVTEDGAD--PNPYVKTYLLPDNHKTSKRKTKISRKT 1618
            G +++ +  + G L + ++  + LV + G+   P PYVK YLL +    +K+KTK++RKT
Sbjct: 1011 GDIQVGMMDKKGQLEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVARKT 1070

Query: 1619 RNPTFNEMLVYSGYSKETLRQRELQLSVLSAES-LRENFFLGGVTLPLKDFNLSKETVKW 1677
              P + ++L +    +E+ + + LQ+ V      +    F+G   + L +  LS   + W
Sbjct: 1071 LEPLYQQLLSF----EESPQGKVLQIIVWGDYGRMDHKSFMGVAQILLDELELSNMVIGW 1126

Query: 1678 YQL 1680
            ++L
Sbjct: 1127 FKL 1129


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.134    0.391 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 61,765,688
Number of Sequences: 37866
Number of extensions: 2802283
Number of successful extensions: 8462
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 79
Number of HSP's successfully gapped in prelim test: 102
Number of HSP's that attempted gapping in prelim test: 8025
Number of HSP's gapped (non-prelim): 410
length of query: 1686
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1570
effective length of database: 13,855,062
effective search space: 21752447340
effective search space used: 21752447340
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.