Search of human proteins with 156938340

Search of human proteins with 156938340

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|156938340 transmembrane tryptase preproprotein [Homo
sapiens]
         (321 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|156938340 transmembrane tryptase preproprotein [Homo sapiens]      676   0.0  
gi|68508970 tryptase beta 2 precursor [Homo sapiens]                  235   4e-62
gi|13994276 marapsin [Homo sapiens]                                   234   8e-62
gi|13775595 tryptase alpha/beta 1 precursor [Homo sapiens]            233   2e-61
gi|117956391 protease, serine, 33 [Homo sapiens]                      226   3e-59
gi|21614531 testisin isoform 2 [Homo sapiens]                         225   5e-59
gi|5803197 testisin isoform 1 [Homo sapiens]                          223   2e-58
gi|205360905 testis-specific serine protease 1 [Homo sapiens]         221   5e-58
gi|4506153 prostasin preproprotein [Homo sapiens]                     220   1e-57
gi|11545839 protease, serine, 22 [Homo sapiens]                       218   6e-57
gi|58218970 protease, serine, 36 [Homo sapiens]                       218   7e-57
gi|21614533 testisin isoform 3 [Homo sapiens]                         208   5e-54
gi|116256363 transmembrane protease, serine 13 [Homo sapiens]         200   2e-51
gi|23957702 transmembrane protease, serine 6 [Homo sapiens]           197   1e-50
gi|78191798 plasma kallikrein B1 precursor [Homo sapiens]             194   1e-49
gi|4505881 plasminogen [Homo sapiens]                                 190   2e-48
gi|148806900 epidermis-specific serine protease-like protein [Ho...   186   2e-47
gi|34098976 marapsin 2 [Homo sapiens]                                 185   5e-47
gi|145701030 transmembrane protease, serine 4 isoform 3 [Homo sa...   182   3e-46
gi|15451940 transmembrane protease, serine 4 isoform 1 [Homo sap...   182   3e-46
gi|4758508 transmembrane protease, serine 11D [Homo sapiens]          181   6e-46
gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo sap...   181   8e-46
gi|148613878 acrosin precursor [Homo sapiens]                         181   8e-46
gi|187761337 transmembrane protease, serine 11B [Homo sapiens]        180   1e-45
gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo sa...   180   2e-45
gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo sa...   180   2e-45
gi|170932492 transmembrane protease, serine 5 [Homo sapiens]          180   2e-45
gi|222831592 transmembrane protease, serine 7 [Homo sapiens]          178   5e-45
gi|116292750 lipoprotein Lp(a) precursor [Homo sapiens]               177   1e-44
gi|11321636 tryptase delta 1 [Homo sapiens]                           176   2e-44

>gi|156938340 transmembrane tryptase preproprotein [Homo sapiens]
          Length = 321

 Score =  676 bits (1745), Expect = 0.0
 Identities = 321/321 (100%), Positives = 321/321 (100%)

Query: 1   MALGACGLLLLLAVPGVSLRTLQPGCGRPQVSDAGGRIVGGHAAPAGAWPWQASLRLRRV 60
           MALGACGLLLLLAVPGVSLRTLQPGCGRPQVSDAGGRIVGGHAAPAGAWPWQASLRLRRV
Sbjct: 1   MALGACGLLLLLAVPGVSLRTLQPGCGRPQVSDAGGRIVGGHAAPAGAWPWQASLRLRRV 60

Query: 61  HVCGGSLLSPQWVLTAAHCFSGSLNSSDYQVHLGELEITLSPHFSTVRQIILHSSPSGQP 120
           HVCGGSLLSPQWVLTAAHCFSGSLNSSDYQVHLGELEITLSPHFSTVRQIILHSSPSGQP
Sbjct: 61  HVCGGSLLSPQWVLTAAHCFSGSLNSSDYQVHLGELEITLSPHFSTVRQIILHSSPSGQP 120

Query: 121 GTSGDIALVELSVPVTLSSRILPVCLPEASDDFCPGIRCWVTGWGYTREGEPLPPPYSLR 180
           GTSGDIALVELSVPVTLSSRILPVCLPEASDDFCPGIRCWVTGWGYTREGEPLPPPYSLR
Sbjct: 121 GTSGDIALVELSVPVTLSSRILPVCLPEASDDFCPGIRCWVTGWGYTREGEPLPPPYSLR 180

Query: 181 EVKVSVVDTETCRRDYPGPGGSILQPDMLCARGPGDACQDDSGGPLVCQVNGAWVQAGIV 240
           EVKVSVVDTETCRRDYPGPGGSILQPDMLCARGPGDACQDDSGGPLVCQVNGAWVQAGIV
Sbjct: 181 EVKVSVVDTETCRRDYPGPGGSILQPDMLCARGPGDACQDDSGGPLVCQVNGAWVQAGIV 240

Query: 241 SWGEGCGRPNRPGVYTRVPAYVNWIRRHITASGGSESGYPRLPLLAGFFLPGLFLLLVSC 300
           SWGEGCGRPNRPGVYTRVPAYVNWIRRHITASGGSESGYPRLPLLAGFFLPGLFLLLVSC
Sbjct: 241 SWGEGCGRPNRPGVYTRVPAYVNWIRRHITASGGSESGYPRLPLLAGFFLPGLFLLLVSC 300

Query: 301 VLLAKCLLHPSADGTPFPAPD 321
           VLLAKCLLHPSADGTPFPAPD
Sbjct: 301 VLLAKCLLHPSADGTPFPAPD 321


>gi|68508970 tryptase beta 2 precursor [Homo sapiens]
          Length = 275

 Score =  235 bits (599), Expect = 4e-62
 Identities = 127/272 (46%), Positives = 164/272 (60%), Gaps = 15/272 (5%)

Query: 9   LLLLAVPGVSLRTLQPGCGRPQVSDAGGRIVGGHAAPAGAWPWQASLRLRR---VHVCGG 65
           LLLLA+P ++ R          +   G  IVGG  AP   WPWQ SLR+R    +H CGG
Sbjct: 4   LLLLALPVLASRAYAAPAPGQALQRVG--IVGGQEAPRSKWPWQVSLRVRDRYWMHFCGG 61

Query: 66  SLLSPQWVLTAAHCFSGSLNS-SDYQVHLGELEITLSPHFSTVRQIILHSS-PSGQPGTS 123
           SL+ PQWVLTAAHC    +   +  +V L E  +        V +II+H    + Q G  
Sbjct: 62  SLIHPQWVLTAAHCVGPDVKDLAALRVQLREQHLYYQDQLLPVSRIIVHPQFYTAQIGA- 120

Query: 124 GDIALVELSVPVTLSSRILPVCLPEASDDFCPGIRCWVTGWGYTREGEPLPPPYSLREVK 183
            DIAL+EL  PV +SS +  V LP AS+ F PG+ CWVTGWG     E LPPP+ L++VK
Sbjct: 121 -DIALLELEEPVNVSSHVHTVTLPPASETFPPGMPCWVTGWGDVDNDERLPPPFPLKQVK 179

Query: 184 VSVVDTETCRRDY-----PGPGGSILQPDMLCARGPG-DACQDDSGGPLVCQVNGAWVQA 237
           V +++   C   Y      G    I++ DMLCA     D+CQ DSGGPLVC+VNG W+QA
Sbjct: 180 VPIMENHICDAKYHLGAYTGDDVRIVRDDMLCAGNTRRDSCQGDSGGPLVCKVNGTWLQA 239

Query: 238 GIVSWGEGCGRPNRPGVYTRVPAYVNWIRRHI 269
           G+VSWGEGC +PNRPG+YTRV  Y++WI  ++
Sbjct: 240 GVVSWGEGCAQPNRPGIYTRVTYYLDWIHHYV 271


>gi|13994276 marapsin [Homo sapiens]
          Length = 290

 Score =  234 bits (597), Expect = 8e-62
 Identities = 129/273 (47%), Positives = 165/273 (60%), Gaps = 17/273 (6%)

Query: 9   LLLLAVPGVSLRTLQPGCGRPQVSDAGGRIVGGHAAPAGAWPWQASLRLRRVHVCGGSLL 68
           LLLL   G         CGRP++ +   R+VGG     G WPWQ S++    H CGGSL+
Sbjct: 9   LLLLLCFGSQRAKAATACGRPRMLN---RMVGGQDTQEGEWPWQVSIQRNGSHFCGGSLI 65

Query: 69  SPQWVLTAAHCFSGSLNSSDYQVHLGELEITL-SPH--FSTVRQIILHSSPSGQ-PGTSG 124
           + QWVLTAAHCF  +  +S YQV LG  ++    PH  ++ VRQ+   S+P  Q   +S 
Sbjct: 66  AEQWVLTAAHCFRNTSETSLYQVLLGARQLVQPGPHAMYARVRQV--ESNPLYQGTASSA 123

Query: 125 DIALVELSVPVTLSSRILPVCLPEASDDFCPGIRCWVTGWGYTREGEPLPPPYSLREVKV 184
           D+ALVEL  PV  ++ ILPVCLP+ S  F  G+ CWVTGWG   E + LP P  L+++ V
Sbjct: 124 DVALVELEAPVPFTNYILPVCLPDPSVIFETGMNCWVTGWGSPSEEDLLPEPRILQKLAV 183

Query: 185 SVVDTETCRRDYP-----GPGGSILQPDMLCA---RGPGDACQDDSGGPLVCQVNGAWVQ 236
            ++DT  C   Y      G     ++ DMLCA    G  DAC+ DSGGPLVC V  +W+Q
Sbjct: 184 PIIDTPKCNLLYSKDTEFGYQPKTIKNDMLCAGFEEGKKDACKGDSGGPLVCLVGQSWLQ 243

Query: 237 AGIVSWGEGCGRPNRPGVYTRVPAYVNWIRRHI 269
           AG++SWGEGC R NRPGVY RV A+ NWI R I
Sbjct: 244 AGVISWGEGCARQNRPGVYIRVTAHHNWIHRII 276


>gi|13775595 tryptase alpha/beta 1 precursor [Homo sapiens]
          Length = 275

 Score =  233 bits (594), Expect = 2e-61
 Identities = 126/272 (46%), Positives = 163/272 (59%), Gaps = 15/272 (5%)

Query: 9   LLLLAVPGVSLRTLQPGCGRPQVSDAGGRIVGGHAAPAGAWPWQASLRLRR---VHVCGG 65
           LLLLA+P ++ R          +   G  IVGG  AP   WPWQ SLR+     +H CGG
Sbjct: 4   LLLLALPVLASRAYAAPAPGQALQRVG--IVGGQEAPRSKWPWQVSLRVHGPYWMHFCGG 61

Query: 66  SLLSPQWVLTAAHCFSGSLNS-SDYQVHLGELEITLSPHFSTVRQIILHSS-PSGQPGTS 123
           SL+ PQWVLTAAHC    +   +  +V L E  +        V +II+H    + Q G  
Sbjct: 62  SLIHPQWVLTAAHCVGPDVKDLAALRVQLREQHLYYQDQLLPVSRIIVHPQFYTAQIGA- 120

Query: 124 GDIALVELSVPVTLSSRILPVCLPEASDDFCPGIRCWVTGWGYTREGEPLPPPYSLREVK 183
            DIAL+EL  PV +SS +  V LP AS+ F PG+ CWVTGWG     E LPPP+ L++VK
Sbjct: 121 -DIALLELEEPVNVSSHVHTVTLPPASETFPPGMPCWVTGWGDVDNDERLPPPFPLKQVK 179

Query: 184 VSVVDTETCRRDY-----PGPGGSILQPDMLCARGPG-DACQDDSGGPLVCQVNGAWVQA 237
           V +++   C   Y      G    I++ DMLCA     D+CQ DSGGPLVC+VNG W+QA
Sbjct: 180 VPIMENHICDAKYHLGAYTGDDVRIVRDDMLCAGNTRRDSCQGDSGGPLVCKVNGTWLQA 239

Query: 238 GIVSWGEGCGRPNRPGVYTRVPAYVNWIRRHI 269
           G+VSWGEGC +PNRPG+YTRV  Y++WI  ++
Sbjct: 240 GVVSWGEGCAQPNRPGIYTRVTYYLDWIHHYV 271


>gi|117956391 protease, serine, 33 [Homo sapiens]
          Length = 280

 Score =  226 bits (575), Expect = 3e-59
 Identities = 128/275 (46%), Positives = 165/275 (60%), Gaps = 18/275 (6%)

Query: 8   LLLLLAVPGVSLRTLQPGCGRPQVSDAGGRIVGGHAAPAGAWPWQASLRLRRVHVCGGSL 67
           LLL+L   G   R     CG+P++S    RIVGG     G WPWQAS++ R  HVCGGSL
Sbjct: 11  LLLVLGAAGTQGRK-SAACGQPRMSS---RIVGGRDGRDGEWPWQASIQHRGAHVCGGSL 66

Query: 68  LSPQWVLTAAHCFSGSLNSSDYQVHLGELEI-TLSPHFSTV--RQIILHSSPSGQPGTSG 124
           ++PQWVLTAAHCF      ++Y+V LG L + + SP   +V  R+++L    S + G  G
Sbjct: 67  IAPQWVLTAAHCFPRRALPAEYRVRLGALRLGSTSPRTLSVPVRRVLLPPDYS-EDGARG 125

Query: 125 DIALVELSVPVTLSSRILPVCLPEASDDFCPGIRCWVTGWGYTREGEPLPPPYSLREVKV 184
           D+AL++L  PV LS+R+ PVCLP       PG  C VTGWG  R G PLP    L+ V+V
Sbjct: 126 DLALLQLRRPVPLSARVQPVCLPVPGARPPPGTPCRVTGWGSLRPGVPLPEWRPLQGVRV 185

Query: 185 SVVDTETCR------RDYPGPGGSILQPDMLCA---RGPGDACQDDSGGPLVCQVNGAWV 235
            ++D+ TC        D P     I+ P  LCA   +G  DACQ DSGGPL C  +G+WV
Sbjct: 186 PLLDSRTCDGLYHVGADVP-QAERIVLPGSLCAGYPQGHKDACQGDSGGPLTCLQSGSWV 244

Query: 236 QAGIVSWGEGCGRPNRPGVYTRVPAYVNWIRRHIT 270
             G+VSWG+GC  PNRPGVYT V  Y  WI+  ++
Sbjct: 245 LVGVVSWGKGCALPNRPGVYTSVATYSPWIQARVS 279


>gi|21614531 testisin isoform 2 [Homo sapiens]
          Length = 312

 Score =  225 bits (573), Expect = 5e-59
 Identities = 139/321 (43%), Positives = 178/321 (55%), Gaps = 43/321 (13%)

Query: 2   ALGACGLLLLLAVPGV------SLRTLQPGCGRPQVSDAGGRIVGGHAAPAGAWPWQASL 55
           A GA  L LLLA  G+          L   CGR  ++    RIVGG  A  G WPWQ SL
Sbjct: 3   ARGALLLALLLARAGLRKPESQEAAPLSGPCGRRVITS---RIVGGEDAELGRWPWQGSL 59

Query: 56  RLRRVHVCGGSLLSPQWVLTAAHCFSGSLNS-SDYQVHLGELEITLSPHFSTVRQII--- 111
           RL   HVCG SLLS +W LTAAHCF   L+  S + V  G+L  T  P F +++      
Sbjct: 60  RLWDSHVCGVSLLSHRWALTAAHCFETDLSDPSGWMVQFGQL--TSMPSFWSLQAYYTRY 117

Query: 112 ----LHSSPSGQPGTSGDIALVELSVPVTLSSRILPVCLPEASDDFCPGIRCWVTGWGYT 167
               ++ SP     +  DIALV+LS PVT +  I P+CL  ++ +F     CWVTGWGY 
Sbjct: 118 FVSNIYLSPRYLGNSPYDIALVKLSAPVTYTKHIQPICLQASTFEFENRTDCWVTGWGYI 177

Query: 168 REGEPLPPPYSLREVKVSVVDTETC---------RRDYPGPGGSILQPDMLCA---RGPG 215
           +E E LP P++L+EV+V++++   C         R+D  G        DM+CA   +G  
Sbjct: 178 KEDEALPSPHTLQEVQVAIINNSMCNHLFLKYSFRKDIFG--------DMVCAGNAQGGK 229

Query: 216 DACQDDSGGPLVCQVNGAWVQAGIVSWGEGCGRPNRPGVYTRVPAYVNWIRRHITASGGS 275
           DAC  DSGGPL C  NG W Q G+VSWG GCGRPNRPGVYT +  +  WI++ +  SG S
Sbjct: 230 DACFGDSGGPLACNKNGLWYQIGVVSWGVGCGRPNRPGVYTNISHHFEWIQKLMAQSGMS 289

Query: 276 ESGYPRLPLLAGFFLPGLFLL 296
           +   P  PLL   F P L+ L
Sbjct: 290 QPD-PSWPLL---FFPLLWAL 306


>gi|5803197 testisin isoform 1 [Homo sapiens]
          Length = 314

 Score =  223 bits (568), Expect = 2e-58
 Identities = 139/323 (43%), Positives = 178/323 (55%), Gaps = 45/323 (13%)

Query: 2   ALGACGLLLLLAVPGV------SLRTLQPGCGRPQVSDAGGRIVGGHAAPAGAWPWQASL 55
           A GA  L LLLA  G+          L   CGR  ++    RIVGG  A  G WPWQ SL
Sbjct: 3   ARGALLLALLLARAGLRKPESQEAAPLSGPCGRRVITS---RIVGGEDAELGRWPWQGSL 59

Query: 56  RLRRVHVCGGSLLSPQWVLTAAHCFSGSLNSSD---YQVHLGELEITLSPHFSTVRQII- 111
           RL   HVCG SLLS +W LTAAHCF    + SD   + V  G+L  T  P F +++    
Sbjct: 60  RLWDSHVCGVSLLSHRWALTAAHCFETYSDLSDPSGWMVQFGQL--TSMPSFWSLQAYYT 117

Query: 112 ------LHSSPSGQPGTSGDIALVELSVPVTLSSRILPVCLPEASDDFCPGIRCWVTGWG 165
                 ++ SP     +  DIALV+LS PVT +  I P+CL  ++ +F     CWVTGWG
Sbjct: 118 RYFVSNIYLSPRYLGNSPYDIALVKLSAPVTYTKHIQPICLQASTFEFENRTDCWVTGWG 177

Query: 166 YTREGEPLPPPYSLREVKVSVVDTETC---------RRDYPGPGGSILQPDMLCA---RG 213
           Y +E E LP P++L+EV+V++++   C         R+D  G        DM+CA   +G
Sbjct: 178 YIKEDEALPSPHTLQEVQVAIINNSMCNHLFLKYSFRKDIFG--------DMVCAGNAQG 229

Query: 214 PGDACQDDSGGPLVCQVNGAWVQAGIVSWGEGCGRPNRPGVYTRVPAYVNWIRRHITASG 273
             DAC  DSGGPL C  NG W Q G+VSWG GCGRPNRPGVYT +  +  WI++ +  SG
Sbjct: 230 GKDACFGDSGGPLACNKNGLWYQIGVVSWGVGCGRPNRPGVYTNISHHFEWIQKLMAQSG 289

Query: 274 GSESGYPRLPLLAGFFLPGLFLL 296
            S+   P  PLL   F P L+ L
Sbjct: 290 MSQPD-PSWPLL---FFPLLWAL 308


>gi|205360905 testis-specific serine protease 1 [Homo sapiens]
          Length = 318

 Score =  221 bits (564), Expect = 5e-58
 Identities = 135/318 (42%), Positives = 177/318 (55%), Gaps = 30/318 (9%)

Query: 2   ALGACGLLLLLAVPGVS----LRTLQPGCGRPQVSDAGGR------------IVGGHAAP 45
           A GA  L LLLA  G+     L  LQ G G  +    GGR            + GG  + 
Sbjct: 3   ARGALLLALLLARAGLGKPGELGALQAGPGAARRPGGGGREEACGHREIHALVAGGVESA 62

Query: 46  AGAWPWQASLRLRRVHVCGGSLLSPQWVLTAAHCFSGSLNSSDYQVHLGELEITLSPH-- 103
            G WPWQASLRLRR H CGGSLLS +WVL+AAHCF      S++ V LGEL    +P   
Sbjct: 63  RGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQKHYYPSEWTVQLGELTSRPTPWNL 122

Query: 104 --FST---VRQIILHSSPSGQPGTSGDIALVELSVPVTLSSRILPVCLPEASDDFCPGIR 158
             +S+   V+ II++    G      DIAL+ L+  VT ++ I P+C+  ++ +F     
Sbjct: 123 RAYSSRYKVQDIIVNPDALGV--LRNDIALLRLASSVTYNAYIQPICIESSTFNFVHRPD 180

Query: 159 CWVTGWGY-TREGEPLPPPYSLREVKVSVVDTETCRRDYPGPGG-SILQPDMLCAR---G 213
           CWVTGWG  +  G PLPPPY+LRE +V++++   C   +  P   S++   M CA    G
Sbjct: 181 CWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNYLFEQPSSRSMIWDSMFCAGAEDG 240

Query: 214 PGDACQDDSGGPLVCQVNGAWVQAGIVSWGEGCGRPNRPGVYTRVPAYVNWIRRHITASG 273
             D C+ DSGGPLVC  +G W Q GIVSWG  CG+PNRPGVYT +  Y +WIRR ++ S 
Sbjct: 241 SVDTCKGDSGGPLVCDKDGLWYQVGIVSWGMDCGQPNRPGVYTNISVYFHWIRRVMSHST 300

Query: 274 GSESGYPRLPLLAGFFLP 291
              +    L LLA  + P
Sbjct: 301 PRPNPSQLLLLLALLWAP 318


>gi|4506153 prostasin preproprotein [Homo sapiens]
          Length = 343

 Score =  220 bits (561), Expect = 1e-57
 Identities = 124/281 (44%), Positives = 159/281 (56%), Gaps = 19/281 (6%)

Query: 3   LGACGLLLLLAV--PGVSLRTLQPGCG-RPQVSDAGGRIVGGHAAPAGAWPWQASLRLRR 59
           LGA  +LL L +   G      +  CG  PQ      RI GG +A AG WPWQ S+    
Sbjct: 12  LGAVAILLYLGLLRSGTGAEGAEAPCGVAPQA-----RITGGSSAVAGQWPWQVSITYEG 66

Query: 60  VHVCGGSLLSPQWVLTAAHCFSGSLNSSDYQVHLGELEI---TLSPHFSTVRQIILHSSP 116
           VHVCGGSL+S QWVL+AAHCF    +   Y+V LG  ++   +     ST++ II H S 
Sbjct: 67  VHVCGGSLVSEQWVLSAAHCFPSEHHKEAYEVKLGAHQLDSYSEDAKVSTLKDIIPHPSY 126

Query: 117 SGQPGTSGDIALVELSVPVTLSSRILPVCLPEASDDFCPGIRCWVTGWGYTREGEPLPPP 176
             Q G+ GDIAL++LS P+T S  I P+CLP A+  F  G+ C VTGWG+      L  P
Sbjct: 127 L-QEGSQGDIALLQLSRPITFSRYIRPICLPAANASFPNGLHCTVTGWGHVAPSVSLLTP 185

Query: 177 YSLREVKVSVVDTETCRR----DYPGPGGSILQPDMLCA---RGPGDACQDDSGGPLVCQ 229
             L++++V ++  ETC      D        +Q DM+CA    G  DACQ DSGGPL C 
Sbjct: 186 KPLQQLEVPLISRETCNCLYNIDAKPEEPHFVQEDMVCAGYVEGGKDACQGDSGGPLSCP 245

Query: 230 VNGAWVQAGIVSWGEGCGRPNRPGVYTRVPAYVNWIRRHIT 270
           V G W   GIVSWG+ CG  NRPGVYT   +Y +WI+  +T
Sbjct: 246 VEGLWYLTGIVSWGDACGARNRPGVYTLASSYASWIQSKVT 286


>gi|11545839 protease, serine, 22 [Homo sapiens]
          Length = 317

 Score =  218 bits (555), Expect = 6e-57
 Identities = 117/276 (42%), Positives = 160/276 (57%), Gaps = 14/276 (5%)

Query: 3   LGACGLLLLLAVPGV---SLRTLQPGCGRPQVSDAGGRIVGGHAAPAGAWPWQASLRLRR 59
           LG    LLLLA   +   +   + P CG+PQ  +   R+VGG  +    WPW  S++   
Sbjct: 15  LGTFTSLLLLASTAILNAARIPVPPACGKPQQLN---RVVGGEDSTDSEWPWIVSIQKNG 71

Query: 60  VHVCGGSLLSPQWVLTAAHCFSGSLNSSD-YQVHLGELEITLSPHFST---VRQIILHSS 115
            H C GSLL+ +WV+TAAHCF  +LN    + V LG  ++      S    V  +  H  
Sbjct: 72  THHCAGSLLTSRWVITAAHCFKDNLNKPYLFSVLLGAWQLGNPGSRSQKVGVAWVEPHPV 131

Query: 116 PSGQPGTSGDIALVELSVPVTLSSRILPVCLPEASDDFCPGIRCWVTGWGYTREGEPLPP 175
            S + G   DIALV L   +  S R+LP+CLP+AS    P   CW++GWG  ++G PLP 
Sbjct: 132 YSWKEGACADIALVRLERSIQFSERVLPICLPDASIHLPPNTHCWISGWGSIQDGVPLPH 191

Query: 176 PYSLREVKVSVVDTETCRRDY-PGPGGSILQPDMLCA---RGPGDACQDDSGGPLVCQVN 231
           P +L+++KV ++D+E C   Y  G G   +  DMLCA    G  DAC  DSGGPL+CQV+
Sbjct: 192 PQTLQKLKVPIIDSEVCSHLYWRGAGQGPITEDMLCAGYLEGERDACLGDSGGPLMCQVD 251

Query: 232 GAWVQAGIVSWGEGCGRPNRPGVYTRVPAYVNWIRR 267
           GAW+ AGI+SWGEGC   NRPGVY  + A+ +W+ +
Sbjct: 252 GAWLLAGIISWGEGCAERNRPGVYISLSAHRSWVEK 287


>gi|58218970 protease, serine, 36 [Homo sapiens]
          Length = 855

 Score =  218 bits (554), Expect = 7e-57
 Identities = 127/272 (46%), Positives = 161/272 (59%), Gaps = 23/272 (8%)

Query: 26  CGRPQVSDAGGRIVGGHAAPAGAWPWQASLRLRRVHVCGGSLLSPQWVLTAAHCF--SGS 83
           CGRP+ S    RIVGG  A  G WPWQ SL     H+CGGSL++P WVL+AAHCF  +G+
Sbjct: 38  CGRPEPS---ARIVGGSNAQPGTWPWQVSLHHGGGHICGGSLIAPSWVLSAAHCFMTNGT 94

Query: 84  LN-SSDYQVHLGELEITLSP----HFSTVRQIILHSSPSGQPGTSGDIALVELSVPVTLS 138
           L  ++++ V LG +     P    H   V  I++ ++ S Q     D+AL+ L+ P +L 
Sbjct: 95  LEPAAEWSVLLG-VHSQDGPLDGAHTRAVAAIVVPANYS-QVELGADLALLRLASPASLG 152

Query: 139 SRILPVCLPEASDDFCPGIRCWVTGWGYTREGEPLPPPYSLREVKVSVVDTETCRRDY-- 196
             + PVCLP AS  F  G  CW TGWG  +E +PLP P+ L+EV++ ++   TC+  Y  
Sbjct: 153 PAVWPVCLPRASHRFVHGTACWATGWGDVQEADPLPLPWVLQEVELRLLGEATCQCLYSQ 212

Query: 197 PGPGGSILQ--PDMLCA---RGPGDACQDDSGGPLVCQVNGAWVQAGIVSWGEGCGRPNR 251
           PGP    LQ  P MLCA    G  D CQ DSGGPLVC+  G W QAGI S+G GCGR NR
Sbjct: 213 PGPFNLTLQILPGMLCAGYPEGRRDTCQGDSGGPLVCEEGGRWFQAGITSFGFGCGRRNR 272

Query: 252 PGVYTRVPAYVNWIRRHITASGGSESGYPRLP 283
           PGV+T V  Y  WIR  +    GSE G P  P
Sbjct: 273 PGVFTAVATYEAWIREQVM---GSEPG-PAFP 300



 Score =  104 bits (260), Expect = 9e-23
 Identities = 72/219 (32%), Positives = 100/219 (45%), Gaps = 17/219 (7%)

Query: 41  GHAAPAGAWPWQASLRLRRVHVCGGSLLSPQWVLTAAHCFSGSLNSSDYQVHLGELEITL 100
           G A   GAWPW+A + +     C G+L+S  WVL  A CF    +S      L    + L
Sbjct: 326 GKAPRPGAWPWEAQVMVPGSRPCHGALVSESWVLAPASCFLDPNSSDSPPRDLDAWRVLL 385

Query: 101 S--PHFSTVRQIILHSSPSGQPGTSGDIALVELSVPVTLSSRILPVCLPEASDDFCPGIR 158
              P    V +++ H + S     + D+AL++L  PV LS+   PVCLP     F PG R
Sbjct: 386 PSRPRAERVARLVQHENASWD--NASDLALLQLRTPVNLSAASRPVCLPHPEHYFLPGSR 443

Query: 159 CWVTGWGYTREGEPLPPPYSLREVKVSVVDTETCRRDYPGPGGSIL----QPDMLC---- 210
           C +  WG    GEP   P +L E +  ++    C   Y   G ++      P  LC    
Sbjct: 444 CRLARWG---RGEPALGPGALLEAE--LLGGWWCHCLYGRQGAAVPLPGDPPHALCPAYQ 498

Query: 211 ARGPGDACQDDSGGPLVCQVNGAWVQAGIVSWGEGCGRP 249
            +    +C +DS   L+CQ  G W  AGI  +  GC RP
Sbjct: 499 EKEEVGSCWNDSRWSLLCQEEGTWFLAGIRDFPSGCLRP 537



 Score = 99.4 bits (246), Expect = 4e-21
 Identities = 70/208 (33%), Positives = 95/208 (45%), Gaps = 20/208 (9%)

Query: 43  AAPAGA-WPWQASLRLRRVHVCGGSLLSPQWVLTAAHCF--SGSLNSSDYQVHLGELEIT 99
           AAP G  WPW A + +    VC G LL+P WVL A HC    GS      +V+LG    +
Sbjct: 594 AAPVGVLWPWLAEVHVAGDRVCTGILLAPGWVLAATHCVLRPGSTTVPYIEVYLGRAGAS 653

Query: 100 LSPHFSTVRQIILHSSPSGQPGTSGDIALVELSVPVTLSSRILPVCLPEASDDFCPGIRC 159
             P    V ++++        G    +AL+ELS  V  S   LP+CL  A     PG  C
Sbjct: 654 SLPQGHQVSRLVISIRLPQHLGLRPPLALLELSSRVEPSPSALPICLHPAG--IPPGASC 711

Query: 160 WVTGWGYTREGEPLPPPYSLREVKVSVVDTETCRRDYPGPGGSILQPDMLC---ARGPGD 216
           WV GW   ++  P+          VS++    C   Y G    IL P  LC   A G  +
Sbjct: 712 WVLGWKEPQDRVPV-------AAAVSILTQRICDCLYQG----ILPPGTLCVLYAEGQEN 760

Query: 217 ACQDDSGGPLVCQV-NGAWVQAGIVSWG 243
            C+  S  PL+CQ+  G+W+  G+   G
Sbjct: 761 RCEMTSAPPLLCQMTEGSWILVGMAVQG 788


>gi|21614533 testisin isoform 3 [Homo sapiens]
          Length = 300

 Score =  208 bits (530), Expect = 5e-54
 Identities = 130/311 (41%), Positives = 169/311 (54%), Gaps = 35/311 (11%)

Query: 2   ALGACGLLLLLAVPGV------SLRTLQPGCGRPQVSDAGGRIVGGHAAPAGAWPWQASL 55
           A GA  L LLLA  G+          L   CGR  ++    RIVGG  A  G WPWQ SL
Sbjct: 3   ARGALLLALLLARAGLRKPESQEAAPLSGPCGRRVITS---RIVGGEDAELGRWPWQGSL 59

Query: 56  RLRRVHVCGGSLLSPQWVLTAAHCFSGSLNSSD---YQVHLGELEITLSPHFSTVRQII- 111
           RL   HVCG SLLS +W LTAAHCF    + SD   + V  G+L  T  P F +++    
Sbjct: 60  RLWDSHVCGVSLLSHRWALTAAHCFETYSDLSDPSGWMVQFGQL--TSMPSFWSLQAYYT 117

Query: 112 ------LHSSPSGQPGTSGDIALVELSVPVTLSSRILPVCLPEASDDFCPGIRCWVTGWG 165
                 ++ SP     +  DIALV+LS PVT +  I P+CL  ++ +F     CWVTGWG
Sbjct: 118 RYFVSNIYLSPRYLGNSPYDIALVKLSAPVTYTKHIQPICLQASTFEFENRTDCWVTGWG 177

Query: 166 YTREGEPLPPPYSLREVKVSVVDTETCRRDYPGPGGSILQPDMLCARGPGDACQDDSGGP 225
           Y +E E LP P++L+EV+V++++   C   +        + D+    G       DSGGP
Sbjct: 178 YIKEDEALPSPHTLQEVQVAIINNSMCNHLFLKYS---FRKDIFGDMG-------DSGGP 227

Query: 226 LVCQVNGAWVQAGIVSWGEGCGRPNRPGVYTRVPAYVNWIRRHITASGGSESGYPRLPLL 285
           L C  NG W Q G+VSWG GCGRPNRPGVYT +  +  WI++ +  SG S+   P  PLL
Sbjct: 228 LACNKNGLWYQIGVVSWGVGCGRPNRPGVYTNISHHFEWIQKLMAQSGMSQPD-PSWPLL 286

Query: 286 AGFFLPGLFLL 296
              F P L+ L
Sbjct: 287 ---FFPLLWAL 294


>gi|116256363 transmembrane protease, serine 13 [Homo sapiens]
          Length = 567

 Score =  200 bits (508), Expect = 2e-51
 Identities = 109/253 (43%), Positives = 148/253 (58%), Gaps = 9/253 (3%)

Query: 18  SLRTLQPGCGRPQVSDAGGRIVGGHAAPAGAWPWQASLRLRRVHVCGGSLLSPQWVLTAA 77
           S R +   C    +    GRIVGG  A    WPWQ SL     H+CGG+L+  QWVLTAA
Sbjct: 306 SQRYISLQCSHCGLRAMTGRIVGGALASDSKWPWQVSLHFGTTHICGGTLIDAQWVLTAA 365

Query: 78  HCFSGSLNS--SDYQVHLGELEITLSPHFSTVRQIILHSSPSGQPGTSGDIALVELSVPV 135
           HCF  +       ++V+ G   +   P  +++ +II++S+ + +     DIAL+ LS P+
Sbjct: 366 HCFFVTREKVLEGWKVYAGTSNLHQLPEAASIAEIIINSNYTDEEDDY-DIALMRLSKPL 424

Query: 136 TLSSRILPVCLPEASDDFCPGIRCWVTGWGYTREGEPLPPPYSLREVKVSVVDTETCRRD 195
           TLS+ I P CLP     F     CW+TG+G TRE +    P+ LREV+V+++D + C  D
Sbjct: 425 TLSAHIHPACLPMHGQTFSLNETCWITGFGKTRETDDKTSPF-LREVQVNLIDFKKCN-D 482

Query: 196 YPGPGGSILQPDMLCA---RGPGDACQDDSGGPLVCQVNGAWVQAGIVSWGEGCGRPNRP 252
           Y     S L P M+CA   RG  D+CQ DSGGPLVC+ N  W  AG+ SWG GCG+ N+P
Sbjct: 483 YL-VYDSYLTPRMMCAGDLRGGRDSCQGDSGGPLVCEQNNRWYLAGVTSWGTGCGQRNKP 541

Query: 253 GVYTRVPAYVNWI 265
           GVYT+V   + WI
Sbjct: 542 GVYTKVTEVLPWI 554


>gi|23957702 transmembrane protease, serine 6 [Homo sapiens]
          Length = 811

 Score =  197 bits (500), Expect = 1e-50
 Identities = 114/293 (38%), Positives = 161/293 (54%), Gaps = 40/293 (13%)

Query: 6   CGLLLLLAVPGVSLRTLQPGC-GRPQVSDAG-------------GRIVGGHAAPAGAWPW 51
           CG           ++   P C GRP   D                RIVGG  +  G WPW
Sbjct: 531 CGTFTFQCEDRSCVKKPNPQCDGRPDCRDGSDEEHCDCGLQGPSSRIVGGAVSSEGEWPW 590

Query: 52  QASLRLRRVHVCGGSLLSPQWVLTAAHCFSGSLNSSD--YQVHLGEL--------EITLS 101
           QASL++R  H+CGG+L++ +WV+TAAHCF     +S   + V LG++        E++  
Sbjct: 591 QASLQVRGRHICGGALIADRWVITAAHCFQEDSMASTVLWTVFLGKVWQNSRWPGEVSFK 650

Query: 102 PHFSTVRQIILHSSPSGQPGTSGDIALVELSVPVTLSSRILPVCLPEASDDFCPGIRCWV 161
                V +++LH     +     D+AL++L  PV  S+ + PVCLP  S  F PG+ CW+
Sbjct: 651 -----VSRLLLHPYHE-EDSHDYDVALLQLDHPVVRSAAVRPVCLPARSHFFEPGLHCWI 704

Query: 162 TGWGYTREGEPLPPPYSLREVKVSVVDTETCRRDYPGPGGSILQPDMLCA---RGPGDAC 218
           TGWG  REG P+    +L++V V ++  + C   Y       + P MLCA   +G  DAC
Sbjct: 705 TGWGALREGGPI--SNALQKVDVQLIPQDLCSEVYRYQ----VTPRMLCAGYRKGKKDAC 758

Query: 219 QDDSGGPLVCQ-VNGAWVQAGIVSWGEGCGRPNRPGVYTRVPAYVNWIRRHIT 270
           Q DSGGPLVC+ ++G W  AG+VSWG GCGRPN  GVYTR+   ++WI++ +T
Sbjct: 759 QGDSGGPLVCKALSGRWFLAGLVSWGLGCGRPNYFGVYTRITGVISWIQQVVT 811


>gi|78191798 plasma kallikrein B1 precursor [Homo sapiens]
          Length = 638

 Score =  194 bits (492), Expect = 1e-49
 Identities = 107/268 (39%), Positives = 148/268 (55%), Gaps = 15/268 (5%)

Query: 16  GVSLRTLQPGCGRPQVSDAGGRIVGGHAAPAGAWPWQASLRLRRV---HVCGGSLLSPQW 72
           G SLR    G      +    RIVGG  +  G WPWQ SL+++     H+CGGSL+  QW
Sbjct: 369 GYSLRLCNTGDNSVCTTKTSTRIVGGTNSSWGEWPWQVSLQVKLTAQRHLCGGSLIGHQW 428

Query: 73  VLTAAHCFSGSLNSSDYQVHLGEL---EITLSPHFSTVRQIILHSSPSGQPGTSGDIALV 129
           VLTAAHCF G      ++++ G L   +IT    FS +++II+H +     G   DIAL+
Sbjct: 429 VLTAAHCFDGLPLQDVWRIYSGILNLSDITKDTPFSQIKEIIIHQNYKVSEGNH-DIALI 487

Query: 130 ELSVPVTLSSRILPVCLPEASDDFCPGIRCWVTGWGYTREGEPLPPPYSLREVKVSVVDT 189
           +L  P+  +    P+CLP   D       CWVTGWG+++E   +     L++V + +V  
Sbjct: 488 KLQAPLNYTEFQKPICLPSKGDTSTIYTNCWVTGWGFSKEKGEIQN--ILQKVNIPLVTN 545

Query: 190 ETCRRDYPGPGGSILQPDMLCA---RGPGDACQDDSGGPLVCQVNGAWVQAGIVSWGEGC 246
           E C++ Y       +   M+CA    G  DAC+ DSGGPLVC+ NG W   GI SWGEGC
Sbjct: 546 EECQKRYQDYK---ITQRMVCAGYKEGGKDACKGDSGGPLVCKHNGMWRLVGITSWGEGC 602

Query: 247 GRPNRPGVYTRVPAYVNWIRRHITASGG 274
            R  +PGVYT+V  Y++WI     +S G
Sbjct: 603 ARREQPGVYTKVAEYMDWILEKTQSSDG 630


>gi|4505881 plasminogen [Homo sapiens]
          Length = 810

 Score =  190 bits (482), Expect = 2e-48
 Identities = 107/249 (42%), Positives = 141/249 (56%), Gaps = 21/249 (8%)

Query: 26  CGRPQVSD--AGGRIVGGHAAPAGAWPWQASLRLR-RVHVCGGSLLSPQWVLTAAHCFSG 82
           CG+PQV      GR+VGG  A   +WPWQ SLR R  +H CGG+L+SP+WVLTAAHC   
Sbjct: 567 CGKPQVEPKKCPGRVVGGCVAHPHSWPWQVSLRTRFGMHFCGGTLISPEWVLTAAHCLEK 626

Query: 83  SLNSSDYQVHLG-ELEITLSPHFSTVRQIILHSSPSGQPGTSGDIALVELSVPVTLSSRI 141
           S   S Y+V LG   E+ L PH   +    L   P     T  DIAL++LS P  ++ ++
Sbjct: 627 SPRPSSYKVILGAHQEVNLEPHVQEIEVSRLFLEP-----TRKDIALLKLSSPAVITDKV 681

Query: 142 LPVCLPEASDDFCPGIRCWVTGWGYTRE--GEPLPPPYSLREVKVSVVDTETCRRDYPGP 199
           +P CLP  +        C++TGWG T+   G  L     L+E ++ V++ + C R Y   
Sbjct: 682 IPACLPSPNYVVADRTECFITGWGETQGTFGAGL-----LKEAQLPVIENKVCNR-YEFL 735

Query: 200 GGSILQPDMLCA---RGPGDACQDDSGGPLVCQVNGAWVQAGIVSWGEGCGRPNRPGVYT 256
            G + Q   LCA    G  D+CQ DSGGPLVC     ++  G+ SWG GC RPN+PGVY 
Sbjct: 736 NGRV-QSTELCAGHLAGGTDSCQGDSGGPLVCFEKDKYILQGVTSWGLGCARPNKPGVYV 794

Query: 257 RVPAYVNWI 265
           RV  +V WI
Sbjct: 795 RVSRFVTWI 803


>gi|148806900 epidermis-specific serine protease-like protein [Homo
           sapiens]
          Length = 328

 Score =  186 bits (473), Expect = 2e-47
 Identities = 115/311 (36%), Positives = 164/311 (52%), Gaps = 29/311 (9%)

Query: 1   MALGACGLLLLLAVPGVSLRTLQPGCGRPQVSDAGGRIVGGHAAPAGAWPWQASLRLRRV 60
           M    C   LLL + G+S+      CG+P  S    R+VGG  A AG WPWQ SL     
Sbjct: 1   MGPAGCAFTLLLLL-GISV------CGQPVYSS---RVVGGQDAAAGRWPWQVSLHFDHN 50

Query: 61  HVCGGSLLSPQWVLTAAHCFSGSLNSSDYQVHLGELEITLSPHFST--VRQIILHSSPSG 118
            +CGGSL+S + +LTAAHC   +  +  Y V LG + +  S       V +I++H  P  
Sbjct: 51  FICGGSLVSERLILTAAHCIQPTWTTFSYTVWLGSITVGDSRKRVKYYVSKIVIH--PKY 108

Query: 119 QPGTSGDIALVELSVPVTLSSRILPVCLPEASDDFCPGIRCWVTGWGYTREGEPLPPPYS 178
           Q  T+ D+AL++LS  VT +S ILP+CLP  +        CWVTGWG  +E        +
Sbjct: 109 Q-DTTADVALLKLSSQVTFTSAILPICLPSVTKQLAIPPFCWVTGWGKVKESSDRDYHSA 167

Query: 179 LREVKVSVVDTETCRRDYPGPG------GSILQPDMLCA---RGPGDACQDDSGGPLVCQ 229
           L+E +V ++D + C + Y   G        +++ D +CA   +   D+C+ DSGGPL C 
Sbjct: 168 LQEAEVPIIDRQACEQLYNPIGIFLPALEPVIKEDKICAGDTQNMKDSCKGDSGGPLSCH 227

Query: 230 VNGAWVQAGIVSWGEGCGRPNRPGVYTRVPAYVNWIRRHITASGGSESGYPRLPLLAGFF 289
           ++G W+Q G+VSWG  CG+ + PGVYT V  Y  WI   I+ +   +      P++    
Sbjct: 228 IDGVWIQTGVVSWGLECGK-SLPGVYTNVIYYQKWINATISRANNLDFSDFLFPIV---- 282

Query: 290 LPGLFLLLVSC 300
           L  L LL  SC
Sbjct: 283 LLSLALLRPSC 293


>gi|34098976 marapsin 2 [Homo sapiens]
          Length = 326

 Score =  185 bits (469), Expect = 5e-47
 Identities = 119/324 (36%), Positives = 167/324 (51%), Gaps = 34/324 (10%)

Query: 2   ALGACGLLLLLAVP-------------GVSLRTLQPGCGRPQVSDAGGRIVGGHAAPAGA 48
           ALG   LLL++A P             G+SL T    CGRP +    G+I+GG  AP   
Sbjct: 15  ALGLLLLLLVVAPPRVAALVHRQPENQGISL-TGSVACGRPSME---GKILGGVPAPERK 70

Query: 49  WPWQASLRLRRVHVCGGSLLSPQWVLTAAHCFSGSLNSSDYQVHLGELEITLSPHFST-- 106
           WPWQ S+    +HVCGGS+L+  WVL+AAHCF    N   Y +++G + + ++ + +   
Sbjct: 71  WPWQVSVHYAGLHVCGGSILNEYWVLSAAHCFHRDKNIKIYDMYVGLVNLRVAGNHTQWY 130

Query: 107 -VRQIILHSSPSGQPGTSGDIALVELSVPVTLSSRILPVCL--PEASDDFCPGIRCWVTG 163
            V ++ILH +        GD+ALV+L   +  S  +LPVCL  PE +        CW TG
Sbjct: 131 EVNRVILHPTYEMYHPIGGDVALVQLKTRIVFSESVLPVCLATPEVN---LTSANCWATG 187

Query: 164 WGY-TREGEPLPPPYSLREVKVSVVDTETCRRDYPGPGGSILQPDMLCARGPGDA---CQ 219
           WG  +++GE       L+E+++ ++    C   Y     S + PDMLCA    +A   C+
Sbjct: 188 WGLVSKQGETSD---ELQEMQLPLILEPWCHLLYGHM--SYIMPDMLCAGDILNAKTVCE 242

Query: 220 DDSGGPLVCQVNGAWVQAGIVSWGEGCGRPNRPGVYTRVPAYVNWIRRHITASGGSESGY 279
            DSGGPLVC+ N +W+Q GIVSWG GC  P  PGVY  V  +  WI  +I  +       
Sbjct: 243 GDSGGPLVCEFNRSWLQIGIVSWGRGCSNPLYPGVYASVSYFSKWICDNIEITPTPAQPA 302

Query: 280 PRLPLLAGFFLPGLFLLLVSCVLL 303
           P L    G  L  L  +L    +L
Sbjct: 303 PALSPALGPTLSVLMAMLAGWSVL 326


>gi|145701030 transmembrane protease, serine 4 isoform 3 [Homo
           sapiens]
          Length = 432

 Score =  182 bits (463), Expect = 3e-46
 Identities = 95/234 (40%), Positives = 132/234 (56%), Gaps = 13/234 (5%)

Query: 37  RIVGGHAAPAGAWPWQASLRLRRVHVCGGSLLSPQWVLTAAHCFSGSLNSSDYQVHLGEL 96
           R+VGG  A   +WPWQ S++  + HVCGGS+L P WVLTAAHCF    +  +++V  G  
Sbjct: 199 RVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKHTDVFNWKVRAGSD 258

Query: 97  EITLSPHFSTVRQIILHSSPSGQPGTSGDIALVELSVPVTLSSRILPVCLPEASDDFCPG 156
           ++   P  +  + II+  +P        DIAL++L  P+T S  + P+CLP   ++  P 
Sbjct: 259 KLGSFPSLAVAKIIIIEFNP--MYPKDNDIALMKLQFPLTFSGTVRPICLPFFDEELTPA 316

Query: 157 IRCWVTGWGYTREGEPLPPPYSLREVKVSVVDTETCRRD--YPGPGGSILQPDMLCA--- 211
              W+ GWG+T++         L +  V V+D+  C  D  Y G     +   M+CA   
Sbjct: 317 TPLWIIGWGFTKQNGGKMSDI-LLQASVQVIDSTRCNADDAYQGE----VTEKMMCAGIP 371

Query: 212 RGPGDACQDDSGGPLVCQVNGAWVQAGIVSWGEGCGRPNRPGVYTRVPAYVNWI 265
            G  D CQ DSGGPL+ Q +  W   GIVSWG GCG P+ PGVYT+V AY+NWI
Sbjct: 372 EGGVDTCQGDSGGPLMYQ-SDQWHVVGIVSWGYGCGGPSTPGVYTKVSAYLNWI 424


>gi|15451940 transmembrane protease, serine 4 isoform 1 [Homo
           sapiens]
          Length = 437

 Score =  182 bits (463), Expect = 3e-46
 Identities = 95/234 (40%), Positives = 132/234 (56%), Gaps = 13/234 (5%)

Query: 37  RIVGGHAAPAGAWPWQASLRLRRVHVCGGSLLSPQWVLTAAHCFSGSLNSSDYQVHLGEL 96
           R+VGG  A   +WPWQ S++  + HVCGGS+L P WVLTAAHCF    +  +++V  G  
Sbjct: 204 RVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKHTDVFNWKVRAGSD 263

Query: 97  EITLSPHFSTVRQIILHSSPSGQPGTSGDIALVELSVPVTLSSRILPVCLPEASDDFCPG 156
           ++   P  +  + II+  +P        DIAL++L  P+T S  + P+CLP   ++  P 
Sbjct: 264 KLGSFPSLAVAKIIIIEFNP--MYPKDNDIALMKLQFPLTFSGTVRPICLPFFDEELTPA 321

Query: 157 IRCWVTGWGYTREGEPLPPPYSLREVKVSVVDTETCRRD--YPGPGGSILQPDMLCA--- 211
              W+ GWG+T++         L +  V V+D+  C  D  Y G     +   M+CA   
Sbjct: 322 TPLWIIGWGFTKQNGGKMSDI-LLQASVQVIDSTRCNADDAYQGE----VTEKMMCAGIP 376

Query: 212 RGPGDACQDDSGGPLVCQVNGAWVQAGIVSWGEGCGRPNRPGVYTRVPAYVNWI 265
            G  D CQ DSGGPL+ Q +  W   GIVSWG GCG P+ PGVYT+V AY+NWI
Sbjct: 377 EGGVDTCQGDSGGPLMYQ-SDQWHVVGIVSWGYGCGGPSTPGVYTKVSAYLNWI 429


>gi|4758508 transmembrane protease, serine 11D [Homo sapiens]
          Length = 418

 Score =  181 bits (460), Expect = 6e-46
 Identities = 106/248 (42%), Positives = 141/248 (56%), Gaps = 12/248 (4%)

Query: 25  GCGRPQVSDAGGRIVGGHAAPAGAWPWQASLRLRRVHVCGGSLLSPQWVLTAAHCFSGSL 84
           G G   ++ +  RI+GG  A  G+WPWQ SLRL   H CGGSL++  W+LTAAHCF  + 
Sbjct: 174 GAGPDLITLSEQRILGGTEAEEGSWPWQVSLRLNNAHHCGGSLINNMWILTAAHCFRSNS 233

Query: 85  NSSDYQVHLGELEITLSPHFSTVRQIILHSSPSGQPGTSGDIALVELSVPVTLSSRILPV 144
           N  D+    G +  T       VR I++H++         DIALV L   VT +  I  V
Sbjct: 234 NPRDWIATSG-ISTTFPKLRMRVRNILIHNNYKSAT-HENDIALVRLENSVTFTKDIHSV 291

Query: 145 CLPEASDDFCPGIRCWVTGWGYTR-EGEPLPPPYSLREVKVSVVDTETCRRDYPGPGGSI 203
           CLP A+ +  PG   +VTGWG     G  +P    LR+ +V ++  + C   +    G+I
Sbjct: 292 CLPAATQNIPPGSTAYVTGWGAQEYAGHTVP---ELRQGQVRIISNDVCNAPH-SYNGAI 347

Query: 204 LQPDMLCA---RGPGDACQDDSGGPLVCQ-VNGAWVQAGIVSWGEGCGRPNRPGVYTRVP 259
           L   MLCA   +G  DACQ DSGGPLV +     W   GIVSWG+ CG P++PGVYTRV 
Sbjct: 348 LS-GMLCAGVPQGGVDACQGDSGGPLVQEDSRRLWFIVGIVSWGDQCGLPDKPGVYTRVT 406

Query: 260 AYVNWIRR 267
           AY++WIR+
Sbjct: 407 AYLDWIRQ 414


>gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo
           sapiens]
          Length = 454

 Score =  181 bits (459), Expect = 8e-46
 Identities = 91/236 (38%), Positives = 135/236 (57%), Gaps = 6/236 (2%)

Query: 37  RIVGGHAAPAGAWPWQASLRLRRVHVCGGSLLSPQWVLTAAHCFSGSLNSSDYQVHLGEL 96
           RIVGG+ +    WPWQASL+ +  H+CGGS+++P W++TAAHC         + + +G +
Sbjct: 216 RIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYLPKSWTIQVGLV 275

Query: 97  EITLSPHFSTVRQIILHSSPSGQPGTSGDIALVELSVPVTLSSRILPVCLPEASDDFCPG 156
            +  +P  S + + I++ S         DIAL++L+ P+T +  I PVCLP + ++F  G
Sbjct: 276 SLLDNPAPSHLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNEMIQPVCLPNSEENFPDG 335

Query: 157 IRCWVTGWGYTREGEPLPPPYSLREVKVSVVDTETCRRDYPGPGGSILQPDMLCA---RG 213
             CW +GWG T +G     P  L    V ++  + C  ++    G I+ P MLCA    G
Sbjct: 336 KVCWTSGWGATEDGAGDASPV-LNHAAVPLISNKIC--NHRDVYGGIISPSMLCAGYLTG 392

Query: 214 PGDACQDDSGGPLVCQVNGAWVQAGIVSWGEGCGRPNRPGVYTRVPAYVNWIRRHI 269
             D+CQ DSGGPLVCQ    W   G  S+G GC   N+PGVYTRV ++++WI   +
Sbjct: 393 GVDSCQGDSGGPLVCQERRLWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWIHEQM 448


>gi|148613878 acrosin precursor [Homo sapiens]
          Length = 421

 Score =  181 bits (459), Expect = 8e-46
 Identities = 120/288 (41%), Positives = 150/288 (52%), Gaps = 33/288 (11%)

Query: 8   LLLLLAVPGVSL--RTLQPGCGRP--QVSDAGGRIVGGHAAPAGAWPWQASLRL-----R 58
           +LL+LAV  V+    T    CG    Q    G RIVGG AA  GAWPW  SL++      
Sbjct: 9   ILLVLAVSVVAKDNATCDGPCGLRFRQNPQGGVRIVGGKAAQHGAWPWMVSLQIFTYNSH 68

Query: 59  RVHVCGGSLLSPQWVLTAAHCFSGSLNSSDYQVHLGELEITLSPHFST--------VRQI 110
           R H CGGSLL+ +WVLTAAHCF G  N  D+++  G  EIT   +           V +I
Sbjct: 69  RYHTCGGSLLNSRWVLTAAHCFVGKNNVHDWRLVFGAKEITYGNNKPVKAPLQERYVEKI 128

Query: 111 ILHSSPSGQPGTSG-DIALVELSVPVTLSSRILPVCLPEASDDFCPGIR-CWVTGWGYTR 168
           I+H   +    T G DIALVE++ P++    I P CLP        G + CWV GWGY  
Sbjct: 129 IIHEKYNS--ATEGNDIALVEITPPISCGRFIGPGCLPHFKAGLPRGSQSCWVAGWGYIE 186

Query: 169 EGEPLPPPYSLREVKVSVVDTETCRRD--YPGPGGSILQPDMLCAR---GPGDACQDDSG 223
           E  P P    L E +V ++D + C     Y G     +QP  +CA    G  D CQ DSG
Sbjct: 187 EKAPRPSSI-LMEARVDLIDLDLCNSTQWYNGR----VQPTNVCAGYPVGKIDTCQGDSG 241

Query: 224 GPLVCQ--VNGAWVQAGIVSWGEGCGRPNRPGVYTRVPAYVNWIRRHI 269
           GPL+C+     A+V  GI SWG GC R  RPG+YT    Y+NWI   I
Sbjct: 242 GPLMCKDSKESAYVVVGITSWGVGCARAKRPGIYTATWPYLNWIASKI 289


>gi|187761337 transmembrane protease, serine 11B [Homo sapiens]
          Length = 416

 Score =  180 bits (457), Expect = 1e-45
 Identities = 106/249 (42%), Positives = 143/249 (57%), Gaps = 18/249 (7%)

Query: 26  CGRPQVSDA---GGRIVGGHAAPAGAWPWQASLRLRRVHVCGGSLLSPQWVLTAAHCFSG 82
           CGR QV+++   G +IV G ++  GAWPWQAS++ +  H CG SL+S +W+L+AAHCF+ 
Sbjct: 171 CGR-QVANSIITGNKIVNGKSSLEGAWPWQASMQWKGRHYCGASLISSRWLLSAAHCFAK 229

Query: 83  SLNSSDYQVHLGELEITLSPHFST--VRQIILHSSPSGQPGTSGDIALVELSVPVTLSSR 140
             NS D+ V+ G   I ++  + T  V+ II H + S  PG   DIALV+L+  V+ +  
Sbjct: 230 KNNSKDWTVNFG---IVVNKPYMTRKVQNIIFHENYS-SPGLHDDIALVQLAEEVSFTEY 285

Query: 141 ILPVCLPEASDDFCPGIRCWVTGWGYTREGEPLPPPYSLREVKVSVVDTETCRRDYPGPG 200
           I  +CLPEA           VTGWG          P  L+E  + ++D + C   Y   G
Sbjct: 286 IRKICLPEAKMKLSENDNVVVTGWGTLYMNGSF--PVILQEDFLKIIDNKICNASYAYSG 343

Query: 201 GSILQPDMLCA---RGPGDACQDDSGGPLVC-QVNGAWVQAGIVSWGEGCGRPNRPGVYT 256
              +   MLCA    G  DACQ+DSGGPL        W   GIVSWG+GCG+ N+PGVYT
Sbjct: 344 --FVTDTMLCAGFMSGEADACQNDSGGPLAYPDSRNIWHLVGIVSWGDGCGKKNKPGVYT 401

Query: 257 RVPAYVNWI 265
           RV +Y NWI
Sbjct: 402 RVTSYRNWI 410


>gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo
           sapiens]
          Length = 529

 Score =  180 bits (456), Expect = 2e-45
 Identities = 102/263 (38%), Positives = 143/263 (54%), Gaps = 13/263 (4%)

Query: 17  VSLRTLQPGCGRPQVSDAGGRIVGGHAAPAGAWPWQASLRLRRVHVCGGSLLSPQWVLTA 76
           VSLR +   CG    S    RIVGG +A  GAWPWQ SL ++ VHVCGGS+++P+W++TA
Sbjct: 274 VSLRCI--ACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTA 331

Query: 77  AHCFSGSLNSS-DYQVHLGELEITLSPHFS--TVRQIILHSSPSGQPGTSGDIALVELSV 133
           AHC    LN+   +    G L  +   + +   V ++I H +   +   + DIAL++L  
Sbjct: 332 AHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKT-KNNDIALMKLQK 390

Query: 134 PVTLSSRILPVCLPEASDDFCPGIRCWVTGWGYTREGEPLPPPYSLREVKVSVVDTETCR 193
           P+T +  + PVCLP       P   CW++GWG T E         L   KV +++T+ C 
Sbjct: 391 PLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSE--VLNAAKVLLIETQRCN 448

Query: 194 RDYPGPGGSILQPDMLCA---RGPGDACQDDSGGPLVCQVNGAWVQAGIVSWGEGCGRPN 250
             Y     +++ P M+CA   +G  D+CQ DSGGPLV   N  W   G  SWG GC +  
Sbjct: 449 SRY--VYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAY 506

Query: 251 RPGVYTRVPAYVNWIRRHITASG 273
           RPGVY  V  + +WI R + A G
Sbjct: 507 RPGVYGNVMVFTDWIYRQMRADG 529


>gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo
           sapiens]
          Length = 492

 Score =  180 bits (456), Expect = 2e-45
 Identities = 102/263 (38%), Positives = 143/263 (54%), Gaps = 13/263 (4%)

Query: 17  VSLRTLQPGCGRPQVSDAGGRIVGGHAAPAGAWPWQASLRLRRVHVCGGSLLSPQWVLTA 76
           VSLR +   CG    S    RIVGG +A  GAWPWQ SL ++ VHVCGGS+++P+W++TA
Sbjct: 237 VSLRCI--ACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTA 294

Query: 77  AHCFSGSLNSS-DYQVHLGELEITLSPHFS--TVRQIILHSSPSGQPGTSGDIALVELSV 133
           AHC    LN+   +    G L  +   + +   V ++I H +   +   + DIAL++L  
Sbjct: 295 AHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKT-KNNDIALMKLQK 353

Query: 134 PVTLSSRILPVCLPEASDDFCPGIRCWVTGWGYTREGEPLPPPYSLREVKVSVVDTETCR 193
           P+T +  + PVCLP       P   CW++GWG T E         L   KV +++T+ C 
Sbjct: 354 PLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSE--VLNAAKVLLIETQRCN 411

Query: 194 RDYPGPGGSILQPDMLCA---RGPGDACQDDSGGPLVCQVNGAWVQAGIVSWGEGCGRPN 250
             Y     +++ P M+CA   +G  D+CQ DSGGPLV   N  W   G  SWG GC +  
Sbjct: 412 SRY--VYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAY 469

Query: 251 RPGVYTRVPAYVNWIRRHITASG 273
           RPGVY  V  + +WI R + A G
Sbjct: 470 RPGVYGNVMVFTDWIYRQMRADG 492


>gi|170932492 transmembrane protease, serine 5 [Homo sapiens]
          Length = 457

 Score =  180 bits (456), Expect = 2e-45
 Identities = 110/262 (41%), Positives = 138/262 (52%), Gaps = 18/262 (6%)

Query: 17  VSLRTLQPGCGRPQVSDAGGRIVGGHAAPAGAWPWQASLRLRRVHVCGGSLLSPQWVLTA 76
           VSLR  + G  RP  S    RIVGG +   G WPWQAS+ L   H CGGS+L+P+WV+TA
Sbjct: 202 VSLRCSECGA-RPLAS----RIVGGQSVAPGRWPWQASVALGFRHTCGGSVLAPRWVVTA 256

Query: 77  AHCFSGS--LNSSDYQVHLGELEIT-LSPHFST-VRQIILHSSPSGQPGTSGDIALVELS 132
           AHC         S ++VH G +  + + PH    V +II H   S Q     D+AL+ L 
Sbjct: 257 AHCMHSFRLARLSSWRVHAGLVSHSAVRPHQGALVERIIPHPLYSAQ-NHDYDVALLRLQ 315

Query: 133 VPVTLSSRILPVCLPEASDDFCPGIRCWVTGWGYTREGEPLPPPYSLREVKVSVVDTETC 192
             +  S  +  VCLP     F  G RCWV+GWG+T           L++  V +  T+ C
Sbjct: 316 TALNFSDTVGAVCLPAKEQHFPKGSRCWVSGWGHTHPSHTYSSDM-LQDTVVPLFSTQLC 374

Query: 193 RRDYPGPGGSILQPDMLCAR---GPGDACQDDSGGPLVCQVNGAWVQAGIVSWGEGCGRP 249
                  G   L P MLCA    G  DACQ DSGGPLVC     W   G+VSWG GC  P
Sbjct: 375 NSSCVYSGA--LTPRMLCAGYLDGRADACQGDSGGPLVCPDGDTWRLVGVVSWGRGCAEP 432

Query: 250 NRPGVYTRVPAYVNWIRRHITA 271
           N PGVY +V  +++WI  H TA
Sbjct: 433 NHPGVYAKVAEFLDWI--HDTA 452


>gi|222831592 transmembrane protease, serine 7 [Homo sapiens]
          Length = 717

 Score =  178 bits (452), Expect = 5e-45
 Identities = 103/256 (40%), Positives = 140/256 (54%), Gaps = 16/256 (6%)

Query: 23  QPGCGRPQVSDAGGRIVGGHAAPAGAWPWQASLRLRRVHVCGGSLLSPQWVLTAAHCFSG 82
           + GC   + S A  RI+GG     G WPWQ SL       CG S++S +W+L+AAHCF G
Sbjct: 465 EEGCTCSRSSSALHRIIGGTDTLEGGWPWQVSLHFVGSAYCGASVISREWLLSAAHCFHG 524

Query: 83  SLNS--SDYQVHLGELEITLSPHFSTVRQIILHSSPSGQPGTSGDIALVELSV--PVTLS 138
           +  S  + +  HLG      +   S VR+I++H   + Q     DIAL++LS+  P TL 
Sbjct: 525 NRLSDPTPWTAHLGMYVQGNAKFVSPVRRIVVHEYYNSQT-FDYDIALLQLSIAWPETLK 583

Query: 139 SRILPVCLPEASDDFCPGIRCWVTGWGYTREGEPLPPPYSLREVKVSVVDTETCRRDYPG 198
             I P+C+P        G +CWVTGWG   E +       L++ +V ++D   C   Y  
Sbjct: 584 QLIQPICIPPTGQRVRSGEKCWVTGWGRRHEADN-KGSLVLQQAEVELIDQTLCVSTY-- 640

Query: 199 PGGSILQPDMLCA---RGPGDACQDDSGGPLVC--QVNGAWVQAGIVSWGEGCGRPNRPG 253
               I+   MLCA    G  DAC+ DSGGPL C  + +G W+  GIVSWG G GRPN PG
Sbjct: 641 ---GIITSRMLCAGIMSGKRDACKGDSGGPLSCRRKSDGKWILTGIVSWGHGSGRPNFPG 697

Query: 254 VYTRVPAYVNWIRRHI 269
           VYTRV  +V WI +++
Sbjct: 698 VYTRVSNFVPWIHKYV 713


>gi|116292750 lipoprotein Lp(a) precursor [Homo sapiens]
          Length = 2040

 Score =  177 bits (448), Expect = 1e-44
 Identities = 103/250 (41%), Positives = 133/250 (53%), Gaps = 32/250 (12%)

Query: 26   CGRPQVSD--AGGRIVGGHAAPAGAWPWQASLRLR-RVHVCGGSLLSPQWVLTAAHCFSG 82
            CG+PQV      G IVGG  A   +WPWQ SLR R   H CGG+L+SP+WVLTAAHC   
Sbjct: 1806 CGKPQVEPKKCPGSIVGGCVAHPHSWPWQVSLRTRFGKHFCGGTLISPEWVLTAAHCLKK 1865

Query: 83   SLNSSDYQVHLG-ELEITLSPHFSTVRQIILHSSPSGQPGTSGDIALVELSVPVTLSSRI 141
            S   S Y+V LG   E+ L  H   +    L   P     T  DIAL++LS P  ++ ++
Sbjct: 1866 SSRPSSYKVILGAHQEVNLESHVQEIEVSRLFLEP-----TQADIALLKLSRPAVITDKV 1920

Query: 142  LPVCLPEASDDFCPGIRCWVTGWGYTRE--GEPLPPPYSLREVKVSVVDTETCRRDYPGP 199
            +P CLP           C++TGWG T+   G  L     L+E ++ V++ E C       
Sbjct: 1921 MPACLPSPDYMVTARTECYITGWGETQGTFGTGL-----LKEAQLLVIENEVCNHY---- 1971

Query: 200  GGSILQPDMLCA----RGPGDACQDDSGGPLVCQVNGAWVQAGIVSWGEGCGRPNRPGVY 255
                     +CA    RG  D+CQ DSGGPLVC     ++  G+ SWG GC RPN+PGVY
Sbjct: 1972 -------KYICAEHLARGT-DSCQGDSGGPLVCFEKDKYILQGVTSWGLGCARPNKPGVY 2023

Query: 256  TRVPAYVNWI 265
             RV  +V WI
Sbjct: 2024 ARVSRFVTWI 2033


>gi|11321636 tryptase delta 1 [Homo sapiens]
          Length = 242

 Score =  176 bits (447), Expect = 2e-44
 Identities = 105/234 (44%), Positives = 130/234 (55%), Gaps = 13/234 (5%)

Query: 9   LLLLAVPGVSLRTLQPGCGRPQVSDAGGRIVGGHAAPAGAWPWQASLRLRR---VHVCGG 65
           LLLLA+P ++            +   G  IVGG  AP   WPWQ SLR+R    +H CGG
Sbjct: 11  LLLLALPVLASPAYVAPAPGQALQQTG--IVGGQEAPRSKWPWQVSLRVRGPYWMHFCGG 68

Query: 66  SLLSPQWVLTAAHCFSGSLNS-SDYQVHLGELEITLSPHFSTVRQIILHSSPSGQPGTSG 124
           SL+ PQWVLTAAHC    +   +  +V L E  +        V +II+H        T  
Sbjct: 69  SLIHPQWVLTAAHCVEPDIKDLAALRVQLREQHLYYQDQLLPVSRIIVHPQ-FYIIQTGA 127

Query: 125 DIALVELSVPVTLSSRILPVCLPEASDDFCPGIRCWVTGWGYTREGEPLPPPYSLREVKV 184
           DIAL+EL  PV +SS I  V LP AS+ F PG+ CWVTGWG       LPPPY L+EV+V
Sbjct: 128 DIALLELEEPVNISSHIHTVTLPPASETFPPGMPCWVTGWGDVDNNVHLPPPYPLKEVEV 187

Query: 185 SVVDTETCRRDY-----PGPGGSILQPDMLCARGPG-DACQDDSGGPLVCQVNG 232
            VV+   C  +Y      G    I++ DMLCA     D+CQ DSGGPLVC+VNG
Sbjct: 188 PVVENHLCNAEYHTGLHTGHSFQIVRDDMLCAGSENHDSCQGDSGGPLVCKVNG 241


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.141    0.468 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,562,256
Number of Sequences: 37866
Number of extensions: 954537
Number of successful extensions: 2658
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 167
Number of HSP's successfully gapped in prelim test: 16
Number of HSP's that attempted gapping in prelim test: 1990
Number of HSP's gapped (non-prelim): 216
length of query: 321
length of database: 18,247,518
effective HSP length: 102
effective length of query: 219
effective length of database: 14,385,186
effective search space: 3150355734
effective search space used: 3150355734
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.