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Search of human proteins with 156616273
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|156616273 pleckstrin [Homo sapiens]
(350 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|156616273 pleckstrin [Homo sapiens] 718 0.0
gi|7706643 pleckstrin 2 [Homo sapiens] 251 9e-67
gi|93102364 SWAP-70 protein [Homo sapiens] 55 9e-08
gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo sa... 55 1e-07
gi|154146216 pleckstrin homology domain containing, family A (ph... 54 2e-07
gi|50234893 pleckstrin homology domain containing, family A (pho... 54 3e-07
gi|31377720 pleckstrin homology domain containing, family A (pho... 54 3e-07
gi|145312241 differentially expressed in FDCP 6 homolog [Homo sa... 53 4e-07
gi|7019505 cytohesin 4 [Homo sapiens] 52 1e-06
gi|55770898 Rho GTPase activating protein 25 isoform a [Homo sap... 52 1e-06
gi|7661882 Rho GTPase activating protein 25 isoform b [Homo sapi... 52 1e-06
gi|195972859 cytohesin 2 isoform 2 [Homo sapiens] 51 1e-06
gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens] 51 2e-06
gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens] 51 2e-06
gi|110349763 cytohesin 1 isoform 2 [Homo sapiens] 50 4e-06
gi|34013590 Rho GTPase activating protein 2 [Homo sapiens] 50 4e-06
gi|83716021 GRB2-associated binding protein family, member 4 [Ho... 49 5e-06
gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform... 49 9e-06
gi|46370073 GRB2-associated binding protein 1 isoform b [Homo sa... 48 1e-05
gi|46370071 GRB2-associated binding protein 1 isoform a [Homo sa... 48 1e-05
gi|18105042 GRB2-associated binding protein 2 isoform a [Homo sa... 47 3e-05
gi|8670546 cytohesin 2 isoform 1 [Homo sapiens] 47 3e-05
gi|37595548 phosphoinositol 3-phosphate-binding protein-3 [Homo ... 47 3e-05
gi|4502023 AKT2 kinase [Homo sapiens] 46 4e-05
gi|4758968 cytohesin 3 [Homo sapiens] 46 6e-05
gi|4758964 cytohesin 1 isoform 1 [Homo sapiens] 45 7e-05
gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo sa... 45 7e-05
gi|55741447 pleckstrin homology domain containing, family H (wit... 45 1e-04
gi|19923592 oxysterol binding protein-like 11 [Homo sapiens] 44 2e-04
gi|20070331 oxysterol binding protein-like 9 isoform e [Homo sap... 43 4e-04
>gi|156616273 pleckstrin [Homo sapiens]
Length = 350
Score = 718 bits (1853), Expect = 0.0
Identities = 350/350 (100%), Positives = 350/350 (100%)
Query: 1 MEPKRIREGYLVKKGSVFNTWKPMWVVLLEDGIEFYKKKSDNSPKGMIPLKGSTLTSPCQ 60
MEPKRIREGYLVKKGSVFNTWKPMWVVLLEDGIEFYKKKSDNSPKGMIPLKGSTLTSPCQ
Sbjct: 1 MEPKRIREGYLVKKGSVFNTWKPMWVVLLEDGIEFYKKKSDNSPKGMIPLKGSTLTSPCQ 60
Query: 61 DFGKRMFVFKITTTKQQDHFFQAAFLEERDAWVRDIKKAIKCIEGGQKFARKSTRRSIRL 120
DFGKRMFVFKITTTKQQDHFFQAAFLEERDAWVRDIKKAIKCIEGGQKFARKSTRRSIRL
Sbjct: 61 DFGKRMFVFKITTTKQQDHFFQAAFLEERDAWVRDIKKAIKCIEGGQKFARKSTRRSIRL 120
Query: 121 PETIDLGALYLSMKDTEKGIKELNLEKDKKIFNHCFTGNCVIDWLVSNQSVRNRQEGLMI 180
PETIDLGALYLSMKDTEKGIKELNLEKDKKIFNHCFTGNCVIDWLVSNQSVRNRQEGLMI
Sbjct: 121 PETIDLGALYLSMKDTEKGIKELNLEKDKKIFNHCFTGNCVIDWLVSNQSVRNRQEGLMI 180
Query: 181 ASSLLNEGYLQPAGDMSKSAVDGTAENPFLDNPDAFYYFPDSGFFCEENSSDDDVILKEE 240
ASSLLNEGYLQPAGDMSKSAVDGTAENPFLDNPDAFYYFPDSGFFCEENSSDDDVILKEE
Sbjct: 181 ASSLLNEGYLQPAGDMSKSAVDGTAENPFLDNPDAFYYFPDSGFFCEENSSDDDVILKEE 240
Query: 241 FRGVIIKQGCLLKQGHRRKNWKVRKFILREDPAYLHYYDPAGAEDPLGAIHLRGCVVTSV 300
FRGVIIKQGCLLKQGHRRKNWKVRKFILREDPAYLHYYDPAGAEDPLGAIHLRGCVVTSV
Sbjct: 241 FRGVIIKQGCLLKQGHRRKNWKVRKFILREDPAYLHYYDPAGAEDPLGAIHLRGCVVTSV 300
Query: 301 ESNSNGRKSEEENLFEIITADEVHYFLQAATPKERTEWIRAIQMASRTGK 350
ESNSNGRKSEEENLFEIITADEVHYFLQAATPKERTEWIRAIQMASRTGK
Sbjct: 301 ESNSNGRKSEEENLFEIITADEVHYFLQAATPKERTEWIRAIQMASRTGK 350
>gi|7706643 pleckstrin 2 [Homo sapiens]
Length = 353
Score = 251 bits (640), Expect = 9e-67
Identities = 133/352 (37%), Positives = 207/352 (58%), Gaps = 11/352 (3%)
Query: 1 MEPKRIREGYLVKKGSVFNTWKPMWVVLLEDGIEFYKKKSDNS---PKGMIPLKGSTLTS 57
ME ++EG+LVK+G + + WK W +L ++ + +YK + PKG I L G T+T
Sbjct: 1 MEDGVLKEGFLVKRGHIVHNWKARWFILRQNTLVYYKLEGGRRVTPPKGRILLDGCTITC 60
Query: 58 PCQDFGKRMFVFKITTTKQQDHFFQAAFLEERDAWVRDIKKAIKCIEGGQKFARKSTRRS 117
PC ++ R + K+ T ++F +A EERDAW +I AI + G+ S R S
Sbjct: 61 PCLEYENRPLLIKLKTQTSTEYFLEACSREERDAWAFEITGAIHAGQPGKVQQLHSLRNS 120
Query: 118 IRLPETIDLGALYLSMKDTEKGIKELNLEKDKKIFNHCFTGNCVIDWLVSNQSVRNRQEG 177
+LP I L + M D+ GI+ + + F G+ ++DWL+SN +R E
Sbjct: 121 FKLPPHISLHRIVDKMHDSNTGIRSSPNMEQGSTYKKTFLGSSLVDWLISNSFTASRLEA 180
Query: 178 LMIASSLLNEGYLQPAGDMSKSAV-DGTAENPFLDNPDAFYYFPDSGFFCEENSSDDDVI 236
+ +AS L+ E +L+P G S A+ G FLD+ A Y F +S + ++ S +++
Sbjct: 181 VTLASMLMEENFLRPVGVRSMGAIRSGDLAEQFLDDSTALYTFAES--YKKKISPKEEIS 238
Query: 237 LKE-EFRGVIIKQGCLLKQGHRRKNWKVRKFILREDPAYLHYYDPAGAED-PLGAIHLRG 294
L E G ++KQG L KQGH+RKNWKVR+F+LR+DPA+LHYYDP+ E+ P+G LRG
Sbjct: 239 LSTVELSGTVVKQGYLAKQGHKRKNWKVRRFVLRKDPAFLHYYDPSKEENRPVGGFSLRG 298
Query: 295 CVVTSVESN---SNGRKSEEENLFEIITADEVHYFLQAATPKERTEWIRAIQ 343
+V+++E N + + + + NLF++IT D+ HY++QA++ ER EWI AI+
Sbjct: 299 SLVSALEDNGVPTGVKGNVQGNLFKVITKDDTHYYIQASSKAERAEWIEAIK 350
Score = 55.5 bits (132), Expect = 7e-08
Identities = 38/109 (34%), Positives = 52/109 (47%), Gaps = 9/109 (8%)
Query: 245 IIKQGCLLKQGHRRKNWKVRKFILREDPAYLHYYDPAGAE---DPLGAIHLRGCVVTSVE 301
++K+G L+K+GH NWK R FILR++ L YY G P G I L GC +T
Sbjct: 5 VLKEGFLVKRGHIVHNWKARWFILRQNT--LVYYKLEGGRRVTPPKGRILLDGCTITCPC 62
Query: 302 SNSNGRKSEEENLFEIITADEVHYFLQAATPKERTEWIRAIQMASRTGK 350
R L ++ T YFL+A + +ER W I A G+
Sbjct: 63 LEYENRPL----LIKLKTQTSTEYFLEACSREERDAWAFEITGAIHAGQ 107
Score = 47.0 bits (110), Expect = 3e-05
Identities = 34/104 (32%), Positives = 49/104 (47%), Gaps = 12/104 (11%)
Query: 6 IREGYLVKKGSVFNTWKPMWVVLLEDG--IEFYK-KKSDNSPKGMIPLKGSTLTSPCQDF 62
+++GYL K+G WK VL +D + +Y K +N P G L+GS L S +D
Sbjct: 249 VKQGYLAKQGHKRKNWKVRRFVLRKDPAFLHYYDPSKEENRPVGGFSLRGS-LVSALEDN 307
Query: 63 GKRMFV--------FKITTTKQQDHFFQAAFLEERDAWVRDIKK 98
G V FK+ T ++ QA+ ER W+ IKK
Sbjct: 308 GVPTGVKGNVQGNLFKVITKDDTHYYIQASSKAERAEWIEAIKK 351
>gi|93102364 SWAP-70 protein [Homo sapiens]
Length = 585
Score = 55.1 bits (131), Expect = 9e-08
Identities = 36/99 (36%), Positives = 57/99 (57%), Gaps = 9/99 (9%)
Query: 245 IIKQGCLLKQGHRRKNWKVRKFILREDPAYLHYYDPAGAEDPLGAIHL-RGCVVTSVESN 303
++KQG ++K+GHRRKNW R F+L+ P + YY +D G I L C V S+ +
Sbjct: 211 VLKQGYMMKKGHRRKNWTERWFVLK--PNIISYYVSEDLKDKKGDILLDENCCVESL-PD 267
Query: 304 SNGRKSEEENLFEIITADEVHYFLQAATPKERTEWIRAI 342
+G+K LF + D+ + + A+ K++ EWI+AI
Sbjct: 268 KDGKKC----LFLVKCFDKT-FEISASDKKKKQEWIQAI 301
Score = 39.3 bits (90), Expect = 0.005
Identities = 33/147 (22%), Positives = 61/147 (41%), Gaps = 9/147 (6%)
Query: 6 IREGYLVKKGSVFNTWKPMWVVLLEDGIEFYKKKSDNSPKGMIPLKGSTLTS--PCQDFG 63
+++GY++KKG W W VL + I +Y + KG I L + P +D
Sbjct: 212 LKQGYMMKKGHRRKNWTERWFVLKPNIISYYVSEDLKDKKGDILLDENCCVESLPDKDGK 271
Query: 64 KRMFVFKITTTKQQDHFFQAAFLEERDAWVRDIKKAIKCIEGGQKFARKSTRRSIRLPET 123
K +F+ K + A+ +++ W++ I I ++ G K R+ +
Sbjct: 272 KCLFLVKCF---DKTFEISASDKKKKQEWIQAIHSTIHLLKLGSPPPHKEARQRRKELRK 328
Query: 124 IDLGALYLSMKDTEKGIKELNLEKDKK 150
L ++ E+ +KEL + K
Sbjct: 329 KQLA----EQEELERQMKELQAANESK 351
>gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo
sapiens]
Length = 748
Score = 54.7 bits (130), Expect = 1e-07
Identities = 31/116 (26%), Positives = 55/116 (47%), Gaps = 9/116 (7%)
Query: 6 IREGYLVKKGSVFNTWKPMWVVLLEDGIEFYKKKSDNSPKGMIPLKGSTLTS-PCQDFGK 64
I+ G+L K+G TW W VL D + ++K + + P G I L G+ ++ PC +
Sbjct: 21 IKCGWLRKQGGFVKTWHTRWFVLKGDQLYYFKDEDETKPLGTIFLPGNKVSEHPCNEENP 80
Query: 65 RMFVFKIT--------TTKQQDHFFQAAFLEERDAWVRDIKKAIKCIEGGQKFARK 112
F+F++ T + + A+ + + WV+ I++ I GG F +K
Sbjct: 81 GKFLFEVVPGGDRDRMTANHESYLLMASTQNDMEDWVKSIRRVIWGPFGGGIFGQK 136
Score = 52.0 bits (123), Expect = 8e-07
Identities = 37/125 (29%), Positives = 59/125 (47%), Gaps = 13/125 (10%)
Query: 227 EENSSDDDVILKEEFRGVIIKQGCLLKQGHRRKNWKVRKFILREDPAYLHYYDPAGAEDP 286
EEN+ + + + R IK G L KQG K W R F+L+ D L+Y+ P
Sbjct: 2 EENNDSTENPQQGQGRQNAIKCGWLRKQGGFVKTWHTRWFVLKGD--QLYYFKDEDETKP 59
Query: 287 LGAIHLRGCVVTSVESNSNGRKSEEENLFEII--------TADEVHYFLQAATPKERTEW 338
LG I L G V + ++ + LFE++ TA+ Y L A+T + +W
Sbjct: 60 LGTIFLPG---NKVSEHPCNEENPGKFLFEVVPGGDRDRMTANHESYLLMASTQNDMEDW 116
Query: 339 IRAIQ 343
+++I+
Sbjct: 117 VKSIR 121
>gi|154146216 pleckstrin homology domain containing, family A
(phosphoinositide binding specific) member 2 [Homo
sapiens]
Length = 425
Score = 54.3 bits (129), Expect = 2e-07
Identities = 35/101 (34%), Positives = 54/101 (53%), Gaps = 3/101 (2%)
Query: 245 IIKQGCLLKQGHRRKNWKVRKFILREDPAYLHYYDPAGAEDPLGAIHLRGCVVTSVESNS 304
+IK G +KQG+ RK+WK R F L D + Y+ +PL I L+ + T
Sbjct: 199 LIKSGYCVKQGNVRKSWKRRFFAL--DDFTICYFKCEQDREPLRTIFLKDVLKTHECLVK 256
Query: 305 NGRKSEEENLFEIITADEVHYFLQAATPKERTEWIRAIQMA 345
+G +NLFEIIT+ +++QA +P++ WI+ I A
Sbjct: 257 SGDLLMRDNLFEIITSSRT-FYVQADSPEDMHSWIKEIGAA 296
Score = 47.0 bits (110), Expect = 3e-05
Identities = 31/106 (29%), Positives = 54/106 (50%), Gaps = 5/106 (4%)
Query: 3 PKRIREGYLVKKGSVFNTWKPMWVVLLEDGIEFYKKKSDNSPKGMIPLKGSTLTSPC--- 59
P I+ GY VK+G+V +WK + L + I ++K + D P I LK T C
Sbjct: 197 PPLIKSGYCVKQGNVRKSWKRRFFALDDFTICYFKCEQDREPLRTIFLKDVLKTHECLVK 256
Query: 60 -QDFGKRMFVFKITTTKQQDHFFQAAFLEERDAWVRDIKKAIKCIE 104
D R +F+I T+ + + QA E+ +W+++I A++ ++
Sbjct: 257 SGDLLMRDNLFEIITS-SRTFYVQADSPEDMHSWIKEIGAAVQALK 301
Score = 30.4 bits (67), Expect = 2.5
Identities = 23/86 (26%), Positives = 36/86 (41%), Gaps = 2/86 (2%)
Query: 264 RKFILREDPAYLHYY--DPAGAEDPLGAIHLRGCVVTSVESNSNGRKSEEENLFEIITAD 321
R FIL L +Y +P GA+ S S + ++ + +I A
Sbjct: 28 RYFILDTQANCLLWYMDNPQNLAMGAGAVGALQLTYISKVSIATPKQKPKTPFCFVINAL 87
Query: 322 EVHYFLQAATPKERTEWIRAIQMASR 347
YFLQA K+ +W+ A+ AS+
Sbjct: 88 SQRYFLQANDQKDMKDWVEALNQASK 113
>gi|50234893 pleckstrin homology domain containing, family A
(phosphoinositide binding specific) member 1 [Homo
sapiens]
Length = 404
Score = 53.5 bits (127), Expect = 3e-07
Identities = 33/102 (32%), Positives = 52/102 (50%), Gaps = 3/102 (2%)
Query: 6 IREGYLVKKGSVFNTWKPMWVVLLEDGIEFYKKKSDNSPKGMIPLKGSTLTSPCQ--DFG 63
I+ GY VK+G+V WK + L E+ I ++K + + P +IPLK C+ D
Sbjct: 193 IKAGYCVKQGAVMKNWKRRYFQLDENTIGYFKSELEKEPLRVIPLKEVHKVQECKQSDIM 252
Query: 64 KRMFVFKITTTKQQDHFFQAAFLEERDAWVRDIKKAIKCIEG 105
R +F+I TT + + QA EE +W++ + AI G
Sbjct: 253 MRDNLFEIVTT-SRTFYVQADSPEEMHSWIKAVSGAIVAQRG 293
Score = 53.1 bits (126), Expect = 4e-07
Identities = 35/101 (34%), Positives = 53/101 (52%), Gaps = 5/101 (4%)
Query: 245 IIKQGCLLKQGHRRKNWKVRKFILREDPAYLHYYDPAGAEDPLGAIHLRGCVVTSVESNS 304
+IK G +KQG KNWK R F L E+ + Y+ ++PL I L+ V V+
Sbjct: 192 VIKAGYCVKQGAVMKNWKRRYFQLDENT--IGYFKSELEKEPLRVIPLK--EVHKVQECK 247
Query: 305 NGRKSEEENLFEIITADEVHYFLQAATPKERTEWIRAIQMA 345
+NLFEI+T +++QA +P+E WI+A+ A
Sbjct: 248 QSDIMMRDNLFEIVTTSRT-FYVQADSPEEMHSWIKAVSGA 287
>gi|31377720 pleckstrin homology domain containing, family A
(phosphoinositide binding specific) member 1 [Homo
sapiens]
Length = 404
Score = 53.5 bits (127), Expect = 3e-07
Identities = 33/102 (32%), Positives = 52/102 (50%), Gaps = 3/102 (2%)
Query: 6 IREGYLVKKGSVFNTWKPMWVVLLEDGIEFYKKKSDNSPKGMIPLKGSTLTSPCQ--DFG 63
I+ GY VK+G+V WK + L E+ I ++K + + P +IPLK C+ D
Sbjct: 193 IKAGYCVKQGAVMKNWKRRYFQLDENTIGYFKSELEKEPLRVIPLKEVHKVQECKQSDIM 252
Query: 64 KRMFVFKITTTKQQDHFFQAAFLEERDAWVRDIKKAIKCIEG 105
R +F+I TT + + QA EE +W++ + AI G
Sbjct: 253 MRDNLFEIVTT-SRTFYVQADSPEEMHSWIKAVSGAIVAQRG 293
Score = 53.1 bits (126), Expect = 4e-07
Identities = 35/101 (34%), Positives = 53/101 (52%), Gaps = 5/101 (4%)
Query: 245 IIKQGCLLKQGHRRKNWKVRKFILREDPAYLHYYDPAGAEDPLGAIHLRGCVVTSVESNS 304
+IK G +KQG KNWK R F L E+ + Y+ ++PL I L+ V V+
Sbjct: 192 VIKAGYCVKQGAVMKNWKRRYFQLDENT--IGYFKSELEKEPLRVIPLK--EVHKVQECK 247
Query: 305 NGRKSEEENLFEIITADEVHYFLQAATPKERTEWIRAIQMA 345
+NLFEI+T +++QA +P+E WI+A+ A
Sbjct: 248 QSDIMMRDNLFEIVTTSRT-FYVQADSPEEMHSWIKAVSGA 287
>gi|145312241 differentially expressed in FDCP 6 homolog [Homo
sapiens]
Length = 631
Score = 53.1 bits (126), Expect = 4e-07
Identities = 35/103 (33%), Positives = 55/103 (53%), Gaps = 7/103 (6%)
Query: 245 IIKQGCLLKQGHRRKNWKVRKFILREDPAYLHYYDPAGAEDPLGAIHLRGCVVTSVESNS 304
++KQG L K+GH R+NW R F L+ P+ L Y+ ++ G I L V +
Sbjct: 217 VLKQGYLWKRGHLRRNWAERWFQLQ--PSCLCYFGSEECKEKRGIIPLDAHCCVEVLPDR 274
Query: 305 NGRKSEEENLFEIITADEVHYFLQAATPKERTEWIRAIQMASR 347
+G++ +F + TA+ Y + A+ ++R EW AIQMA R
Sbjct: 275 DGKRC----MFCVKTANRT-YEMSASDTRQRQEWTAAIQMAIR 312
Score = 40.4 bits (93), Expect = 0.002
Identities = 34/149 (22%), Positives = 65/149 (43%), Gaps = 8/149 (5%)
Query: 6 IREGYLVKKGSVFNTWKPMWVVLLEDGIEFYKKKSDNSPKGMIPLKGSTLTS--PCQDFG 63
+++GYL K+G + W W L + ++ + +G+IPL P +D
Sbjct: 218 LKQGYLWKRGHLRRNWAERWFQLQPSCLCYFGSEECKEKRGIIPLDAHCCVEVLPDRDGK 277
Query: 64 KRMFVFKITTTKQQDHFFQAAFLEERDAWVRDIKKAIKCIEGGQKFARKSTRRSIRLPET 123
+ MF K T + + A+ +R W I+ AI+ G+ K ++ R E
Sbjct: 278 RCMFCVK---TANRTYEMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRR--EQ 332
Query: 124 IDLGALYLSMKDTE-KGIKELNLEKDKKI 151
+ + K+ E +++L EK++K+
Sbjct: 333 REQRERRRAAKEEELLRLQQLQEEKERKL 361
>gi|7019505 cytohesin 4 [Homo sapiens]
Length = 394
Score = 51.6 bits (122), Expect = 1e-06
Identities = 30/113 (26%), Positives = 54/113 (47%), Gaps = 19/113 (16%)
Query: 7 REGYLVKKGSVFNTWKPMWVVLLEDGIEFYKKKSDNSPKGMIPLKG---STLTSPCQDF- 62
REG+L+K G TWK W +L ++ + +++ +D P+G+IPL+ + P + F
Sbjct: 262 REGWLLKLGGRVKTWKRRWFILTDNCLYYFEFTTDKEPRGIIPLENLSVQKVDDPKKPFC 321
Query: 63 ---------GKRMFVFK------ITTTKQQDHFFQAAFLEERDAWVRDIKKAI 100
G+++ K + K + + A EERD W+ I+ +I
Sbjct: 322 LELYNPSCRGQKIKACKTDGDGRVVEGKHESYRISATSAEERDQWIESIRASI 374
Score = 40.8 bits (94), Expect = 0.002
Identities = 30/112 (26%), Positives = 52/112 (46%), Gaps = 17/112 (15%)
Query: 247 KQGCLLKQGHRRKNWKVRKFILREDPAYLHYYDPAGAEDPLGAIHLRGCVVTSVES---- 302
++G LLK G R K WK R FIL ++ L+Y++ ++P G I L V V+
Sbjct: 262 REGWLLKLGGRVKTWKRRWFILTDN--CLYYFEFTTDKEPRGIIPLENLSVQKVDDPKKP 319
Query: 303 --------NSNGRK---SEEENLFEIITADEVHYFLQAATPKERTEWIRAIQ 343
+ G+K + + ++ Y + A + +ER +WI +I+
Sbjct: 320 FCLELYNPSCRGQKIKACKTDGDGRVVEGKHESYRISATSAEERDQWIESIR 371
>gi|55770898 Rho GTPase activating protein 25 isoform a [Homo
sapiens]
Length = 645
Score = 51.6 bits (122), Expect = 1e-06
Identities = 34/110 (30%), Positives = 53/110 (48%), Gaps = 12/110 (10%)
Query: 246 IKQGCLLKQGHRRKNWKVRKFILREDPAYLHYYDPAGAEDPLGAIHLRGCVVTSVESNSN 305
IK G L KQ KNW+ R F+LR L+YY P G ++L GC + + +N
Sbjct: 48 IKMGWLKKQRSIVKNWQQRYFVLRAQ--QLYYYKDEEDTKPQGCMYLPGCTIKEIATNP- 104
Query: 306 GRKSEEENLFEIITAD-------EVHYFLQAATPKERTEWIRAIQMASRT 348
+ + +FEII A + Y L A++ E EW++ ++ + T
Sbjct: 105 --EEAGKFVFEIIPASWDQNRMGQDSYVLMASSQAEMEEWVKFLRRVAGT 152
Score = 44.3 bits (103), Expect = 2e-04
Identities = 29/104 (27%), Positives = 52/104 (50%), Gaps = 14/104 (13%)
Query: 6 IREGYLVKKGSVFNTWKPMWVVLLEDGIEFYKKKSDNSPKGMIPLKGSTL----TSPCQD 61
I+ G+L K+ S+ W+ + VL + +YK + D P+G + L G T+ T+P ++
Sbjct: 48 IKMGWLKKQRSIVKNWQQRYFVLRAQQLYYYKDEEDTKPQGCMYLPGCTIKEIATNP-EE 106
Query: 62 FGKRMFVFKITTTK-------QQDHFFQAAFLEERDAWVRDIKK 98
GK FVF+I Q + A+ E + WV+ +++
Sbjct: 107 AGK--FVFEIIPASWDQNRMGQDSYVLMASSQAEMEEWVKFLRR 148
>gi|7661882 Rho GTPase activating protein 25 isoform b [Homo
sapiens]
Length = 638
Score = 51.6 bits (122), Expect = 1e-06
Identities = 34/110 (30%), Positives = 53/110 (48%), Gaps = 12/110 (10%)
Query: 246 IKQGCLLKQGHRRKNWKVRKFILREDPAYLHYYDPAGAEDPLGAIHLRGCVVTSVESNSN 305
IK G L KQ KNW+ R F+LR L+YY P G ++L GC + + +N
Sbjct: 41 IKMGWLKKQRSIVKNWQQRYFVLRAQ--QLYYYKDEEDTKPQGCMYLPGCTIKEIATNP- 97
Query: 306 GRKSEEENLFEIITAD-------EVHYFLQAATPKERTEWIRAIQMASRT 348
+ + +FEII A + Y L A++ E EW++ ++ + T
Sbjct: 98 --EEAGKFVFEIIPASWDQNRMGQDSYVLMASSQAEMEEWVKFLRRVAGT 145
Score = 44.3 bits (103), Expect = 2e-04
Identities = 29/104 (27%), Positives = 52/104 (50%), Gaps = 14/104 (13%)
Query: 6 IREGYLVKKGSVFNTWKPMWVVLLEDGIEFYKKKSDNSPKGMIPLKGSTL----TSPCQD 61
I+ G+L K+ S+ W+ + VL + +YK + D P+G + L G T+ T+P ++
Sbjct: 41 IKMGWLKKQRSIVKNWQQRYFVLRAQQLYYYKDEEDTKPQGCMYLPGCTIKEIATNP-EE 99
Query: 62 FGKRMFVFKITTTK-------QQDHFFQAAFLEERDAWVRDIKK 98
GK FVF+I Q + A+ E + WV+ +++
Sbjct: 100 AGK--FVFEIIPASWDQNRMGQDSYVLMASSQAEMEEWVKFLRR 141
>gi|195972859 cytohesin 2 isoform 2 [Homo sapiens]
Length = 399
Score = 51.2 bits (121), Expect = 1e-06
Identities = 32/132 (24%), Positives = 57/132 (43%), Gaps = 19/132 (14%)
Query: 7 REGYLVKKGSVFNTWKPMWVVLLEDGIEFYKKKSDNSPKGMIPLKGSTLTSPCQDFGKRM 66
REG+L+K G TWK W +L ++ + +++ +D P+G+IPL+ ++
Sbjct: 262 REGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVDDPRKPNC 321
Query: 67 FVFKITTTKQQ----------------DHF---FQAAFLEERDAWVRDIKKAIKCIEGGQ 107
F I K Q +H A EE+D W++ I+ A+ +
Sbjct: 322 FELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQEEKDEWIKSIQAAVSVDPFYE 381
Query: 108 KFARKSTRRSIR 119
A + R S++
Sbjct: 382 MLAARKKRISVK 393
Score = 48.5 bits (114), Expect = 9e-06
Identities = 34/116 (29%), Positives = 58/116 (50%), Gaps = 21/116 (18%)
Query: 247 KQGCLLKQGHRRKNWKVRKFILREDPAYLHYYDPAGAEDPLGAIHLRGCVVTSVES---- 302
++G LLK G R K WK R FIL ++ L+Y++ ++P G I L + V+
Sbjct: 262 REGWLLKLGGRVKTWKRRWFILTDN--CLYYFEYTTDKEPRGIIPLENLSIREVDDPRKP 319
Query: 303 --------NSNGR-----KSEEENLFEIITADEVHYFLQAATPKERTEWIRAIQMA 345
N+ G+ K+E + ++ + + Y + A T +E+ EWI++IQ A
Sbjct: 320 NCFELYIPNNKGQLIKACKTEADG--RVVEGNHMVYRISAPTQEEKDEWIKSIQAA 373
>gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens]
Length = 1047
Score = 50.8 bits (120), Expect = 2e-06
Identities = 38/111 (34%), Positives = 55/111 (49%), Gaps = 10/111 (9%)
Query: 238 KEEFRGVIIKQGCLLKQGHRRKNWKVRKFILREDPAYLHYYD-PAGAEDPLGAIHLRGCV 296
K+ F I+K+G LLK+G + K WK FIL A L Y++ A P G I L C
Sbjct: 468 KDAFYKNIVKKGYLLKKG-KGKRWKNLYFILEGSDAQLIYFESEKRATKPKGLIDLSVCS 526
Query: 297 VTSVESNSNGRKSEEENLFEIITA--DEVHY--FLQAATPKERTEWIRAIQ 343
V V + GR N F+I+ E HY + TP++ +W++ +Q
Sbjct: 527 VYVVHDSLFGR----PNCFQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQ 573
>gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens]
Length = 870
Score = 50.8 bits (120), Expect = 2e-06
Identities = 38/111 (34%), Positives = 55/111 (49%), Gaps = 10/111 (9%)
Query: 238 KEEFRGVIIKQGCLLKQGHRRKNWKVRKFILREDPAYLHYYD-PAGAEDPLGAIHLRGCV 296
K+ F I+K+G LLK+G + K WK FIL A L Y++ A P G I L C
Sbjct: 291 KDAFYKNIVKKGYLLKKG-KGKRWKNLYFILEGSDAQLIYFESEKRATKPKGLIDLSVCS 349
Query: 297 VTSVESNSNGRKSEEENLFEIITA--DEVHY--FLQAATPKERTEWIRAIQ 343
V V + GR N F+I+ E HY + TP++ +W++ +Q
Sbjct: 350 VYVVHDSLFGR----PNCFQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQ 396
>gi|110349763 cytohesin 1 isoform 2 [Homo sapiens]
Length = 397
Score = 49.7 bits (117), Expect = 4e-06
Identities = 35/120 (29%), Positives = 55/120 (45%), Gaps = 29/120 (24%)
Query: 247 KQGCLLKQGHRRKNWKVRKFILREDPAYLHYYDPAGAEDPLGAIHLRGCVVTSVESNSNG 306
++G LLK G R K WK R FIL ++ L+Y++ ++P G I L + VE
Sbjct: 263 REGWLLKLGGRVKTWKRRWFILTDN--CLYYFEYTTDKEPRGIIPLENLSIREVED---- 316
Query: 307 RKSEEENLFE---------------------IITADEVHYFLQAATPKERTEWIRAIQMA 345
S++ N FE ++ + Y + A TP+E+ EWI+ I+ A
Sbjct: 317 --SKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEEWIKCIKAA 374
Score = 47.8 bits (112), Expect = 1e-05
Identities = 29/113 (25%), Positives = 49/113 (43%), Gaps = 19/113 (16%)
Query: 7 REGYLVKKGSVFNTWKPMWVVLLEDGIEFYKKKSDNSPKGMIPLKGSTLTSPCQDFGKRM 66
REG+L+K G TWK W +L ++ + +++ +D P+G+IPL+ ++
Sbjct: 263 REGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDSKKPNC 322
Query: 67 FVFKITTTKQQ-------------------DHFFQAAFLEERDAWVRDIKKAI 100
F I K Q + A EE++ W++ IK AI
Sbjct: 323 FELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEEWIKCIKAAI 375
>gi|34013590 Rho GTPase activating protein 2 [Homo sapiens]
Length = 698
Score = 49.7 bits (117), Expect = 4e-06
Identities = 34/130 (26%), Positives = 60/130 (46%), Gaps = 18/130 (13%)
Query: 6 IREGYLVKKGSVFNTWKPMWVVLLEDGIEFYKKKSDNSPKGMIPLKGSTLTS---PCQDF 62
++ G+L K+ S+ W+ W VL D + +YK K + P+G I L+G+ +T +D
Sbjct: 39 LKAGWLKKQRSIMKNWQQRWFVLRGDQLFYYKDKDEIKPQGFISLQGTQVTELPPGPEDP 98
Query: 63 GKRMFVFKITTTKQQDH--------FFQAAFLEERDAWVRDIKKAIKCIEGGQKFARKST 114
GK +F +++ A+ + + WV+ I++ I GG F +
Sbjct: 99 GKHLFEISPGGAGEREKVPANPEALLLMASSQRDMEDWVQAIRRVIWAPLGGGIFGQ--- 155
Query: 115 RRSIRLPETI 124
RL ET+
Sbjct: 156 ----RLEETV 161
Score = 48.9 bits (115), Expect = 7e-06
Identities = 35/111 (31%), Positives = 54/111 (48%), Gaps = 15/111 (13%)
Query: 243 GVIIKQGCLLKQGHRRKNWKVRKFILREDPAYLHYYDPAGAEDPLGAIHLRGCVVTSVES 302
G ++K G L KQ KNW+ R F+LR D L YY P G I L+G VT +
Sbjct: 36 GPVLKAGWLKKQRSIMKNWQQRWFVLRGD--QLFYYKDKDEIKPQGFISLQGTQVTELPP 93
Query: 303 NSNGRKSEEENLFEI----------ITADEVHYFLQAATPKERTEWIRAIQ 343
G + ++LFEI + A+ L A++ ++ +W++AI+
Sbjct: 94 ---GPEDPGKHLFEISPGGAGEREKVPANPEALLLMASSQRDMEDWVQAIR 141
>gi|83716021 GRB2-associated binding protein family, member 4 [Homo
sapiens]
Length = 574
Score = 49.3 bits (116), Expect = 5e-06
Identities = 35/111 (31%), Positives = 55/111 (49%), Gaps = 12/111 (10%)
Query: 243 GVIIKQGCLLKQGHRRK----NWKVRKFILRE-----DPAYLHYYDPAGAEDPLGAIHLR 293
G ++ G L K +K W+ R FILR DP L YY G++ PL I+L
Sbjct: 38 GHVLYSGWLRKSPPEKKLRLFAWRKRWFILRRGQTSSDPDVLEYYKNDGSKKPLRTINLN 97
Query: 294 GCVVTSVESNSNGRKSEEEN--LFEIITADEVHYFLQAATPKERTEWIRAI 342
C V+ N K E + +F+I T++ ++L A T ++ EW+++I
Sbjct: 98 LCEQLDVDVTLNFNKKEIQKGYMFDIKTSERT-FYLVAETREDMNEWVQSI 147
>gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform 1
[Homo sapiens]
Length = 1045
Score = 48.5 bits (114), Expect = 9e-06
Identities = 29/92 (31%), Positives = 47/92 (51%), Gaps = 2/92 (2%)
Query: 9 GYLVKKGSVFNTWKPMWVVLLEDGIEFYKKKSDNSPKGMIPLKGSTLTSPCQDFG-KRMF 67
G L++K N W+ +WVV + FYK DN P +PL G +LT P + ++ +
Sbjct: 937 GNLLRKFKNSNGWQKLWVVFTNFCLFFYKSHQDNHPLASLPLLGYSLTIPSESENIQKDY 996
Query: 68 VFKITTTKQQDHFFQAAFLEERDAWVRDIKKA 99
VFK+ K ++F+A + W+ I+ A
Sbjct: 997 VFKL-HFKSHVYYFRAESEYTFERWMEVIRSA 1027
>gi|46370073 GRB2-associated binding protein 1 isoform b [Homo
sapiens]
Length = 694
Score = 48.1 bits (113), Expect = 1e-05
Identities = 33/109 (30%), Positives = 50/109 (45%), Gaps = 10/109 (9%)
Query: 243 GVIIKQGCLLKQGHRRK----NWKVRKFILRE-----DPAYLHYYDPAGAEDPLGAIHLR 293
G ++ G L K +K WK R F+LR DP L YY A+ P+ I L
Sbjct: 4 GEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRIIDLN 63
Query: 294 GCVVTSVESNSNGRKSEEENLFEIITADEVHYFLQAATPKERTEWIRAI 342
C N ++ E +F+I T D + ++L A + +E +W+R I
Sbjct: 64 LCQQVDAGLTFNKKEFENSYIFDINTIDRI-FYLVADSEEEMNKWVRCI 111
>gi|46370071 GRB2-associated binding protein 1 isoform a [Homo
sapiens]
Length = 724
Score = 48.1 bits (113), Expect = 1e-05
Identities = 33/109 (30%), Positives = 50/109 (45%), Gaps = 10/109 (9%)
Query: 243 GVIIKQGCLLKQGHRRK----NWKVRKFILRE-----DPAYLHYYDPAGAEDPLGAIHLR 293
G ++ G L K +K WK R F+LR DP L YY A+ P+ I L
Sbjct: 4 GEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRIIDLN 63
Query: 294 GCVVTSVESNSNGRKSEEENLFEIITADEVHYFLQAATPKERTEWIRAI 342
C N ++ E +F+I T D + ++L A + +E +W+R I
Sbjct: 64 LCQQVDAGLTFNKKEFENSYIFDINTIDRI-FYLVADSEEEMNKWVRCI 111
>gi|18105042 GRB2-associated binding protein 2 isoform a [Homo
sapiens]
Length = 676
Score = 47.0 bits (110), Expect = 3e-05
Identities = 28/91 (30%), Positives = 47/91 (51%), Gaps = 6/91 (6%)
Query: 257 RRKNWKVRKFILRE-----DPAYLHYYDPAGAEDPLGAIHLRGCVVTSVESNSNGRKSEE 311
RR WK R FILR DP L YY ++ PL I+L C N ++ ++
Sbjct: 23 RRYAWKKRWFILRSGRMSGDPDVLEYYKNDHSKKPLRIINLNFCEQVDAGLTFNKKELQD 82
Query: 312 ENLFEIITADEVHYFLQAATPKERTEWIRAI 342
+F+I T++ ++L A T ++ +W+++I
Sbjct: 83 SFVFDIKTSERT-FYLVAETEEDMNKWVQSI 112
>gi|8670546 cytohesin 2 isoform 1 [Homo sapiens]
Length = 400
Score = 46.6 bits (109), Expect = 3e-05
Identities = 32/133 (24%), Positives = 57/133 (42%), Gaps = 20/133 (15%)
Query: 7 REGYLVKKGSV-FNTWKPMWVVLLEDGIEFYKKKSDNSPKGMIPLKGSTLTSPCQDFGKR 65
REG+L+K G TWK W +L ++ + +++ +D P+G+IPL+ ++
Sbjct: 262 REGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVDDPRKPN 321
Query: 66 MFVFKITTTKQQ----------------DHF---FQAAFLEERDAWVRDIKKAIKCIEGG 106
F I K Q +H A EE+D W++ I+ A+
Sbjct: 322 CFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQEEKDEWIKSIQAAVSVDPFY 381
Query: 107 QKFARKSTRRSIR 119
+ A + R S++
Sbjct: 382 EMLAARKKRISVK 394
Score = 44.3 bits (103), Expect = 2e-04
Identities = 34/117 (29%), Positives = 58/117 (49%), Gaps = 22/117 (18%)
Query: 247 KQGCLLKQGHRR-KNWKVRKFILREDPAYLHYYDPAGAEDPLGAIHLRGCVVTSVES--- 302
++G LLK G R K WK R FIL ++ L+Y++ ++P G I L + V+
Sbjct: 262 REGWLLKLGGGRVKTWKRRWFILTDN--CLYYFEYTTDKEPRGIIPLENLSIREVDDPRK 319
Query: 303 ---------NSNGR-----KSEEENLFEIITADEVHYFLQAATPKERTEWIRAIQMA 345
N+ G+ K+E + ++ + + Y + A T +E+ EWI++IQ A
Sbjct: 320 PNCFELYIPNNKGQLIKACKTEADG--RVVEGNHMVYRISAPTQEEKDEWIKSIQAA 374
>gi|37595548 phosphoinositol 3-phosphate-binding protein-3 [Homo
sapiens]
Length = 1048
Score = 46.6 bits (109), Expect = 3e-05
Identities = 33/120 (27%), Positives = 57/120 (47%), Gaps = 3/120 (2%)
Query: 7 REGYLVKKGSV-FNTWKPMWVVLLEDGIEFYKKKSDNSPKGMIPLKGSTLTS-PCQDFGK 64
+ G+L K+ S W W VL++ + +YK + + S G IPL + + D
Sbjct: 62 KAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQPSDNIS 121
Query: 65 RMFVFKITTTKQQDHFFQAAFLEERDAWVRDIKKAIKC-IEGGQKFARKSTRRSIRLPET 123
R FK + +FF A EE++AW++ + +A + I QK ++ R S P++
Sbjct: 122 RKHTFKAEHAGVRTYFFSAESPEEQEAWIQAMGEAARVQIPPAQKSVPQAVRHSHEKPDS 181
Score = 42.7 bits (99), Expect = 5e-04
Identities = 34/112 (30%), Positives = 51/112 (45%), Gaps = 6/112 (5%)
Query: 237 LKEEFRGVIIKQGCLLKQGHRR-KNWKVRKFILREDPAYLHYYDPAGAEDPLGAIHLRGC 295
+K + K G L KQ K W R F+L + L YY E LG+I L
Sbjct: 52 MKRNPNAPVTKAGWLFKQASSGVKQWNKRWFVLVD--RCLFYYKDEKEESILGSIPLLSF 109
Query: 296 VVTSVESNSNGRKSEEENLFEIITADEVHYFLQAATPKERTEWIRAIQMASR 347
V +V+ + N ++ F+ A YF A +P+E+ WI+A+ A+R
Sbjct: 110 RVAAVQPSDN---ISRKHTFKAEHAGVRTYFFSAESPEEQEAWIQAMGEAAR 158
>gi|4502023 AKT2 kinase [Homo sapiens]
Length = 481
Score = 46.2 bits (108), Expect = 4e-05
Identities = 33/113 (29%), Positives = 50/113 (44%), Gaps = 14/113 (12%)
Query: 245 IIKQGCLLKQGHRRKNWKVRKFILREDPAYLHYYDPAGAED----PLGAIHLRGCVVTSV 300
+IK+G L K+G K W+ R F+L+ D +++ Y + A D PL + C +
Sbjct: 6 VIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAECQLMKT 65
Query: 301 ESNSNGRKSEEENLFEIIT---ADEVHYFLQAATPKERTEWIRAIQMASRTGK 350
E N F I + +P ER EW+RAIQM + + K
Sbjct: 66 E-------RPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLK 111
Score = 39.7 bits (91), Expect = 0.004
Identities = 26/98 (26%), Positives = 44/98 (44%), Gaps = 6/98 (6%)
Query: 6 IREGYLVKKGSVFNTWKPMWVVLLEDGIEFYKKKSDNSPKGMIPLKGSTLTSPCQDF--- 62
I+EG+L K+G TW+P + +L DG K+ +P +P + + CQ
Sbjct: 7 IKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAECQLMKTE 66
Query: 63 --GKRMFVFK-ITTTKQQDHFFQAAFLEERDAWVRDIK 97
FV + + T + F +ER+ W+R I+
Sbjct: 67 RPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQ 104
>gi|4758968 cytohesin 3 [Homo sapiens]
Length = 399
Score = 45.8 bits (107), Expect = 6e-05
Identities = 32/114 (28%), Positives = 57/114 (50%), Gaps = 21/114 (18%)
Query: 247 KQGCLLKQGHRRKNWKVRKFILREDPAYLHYYDPAGAEDPLGAIHLRGCVVTSVES---- 302
++G LLK G R K WK R FIL ++ L+Y++ ++P G I L + VE
Sbjct: 267 REGWLLKLGGRVKTWKRRWFILTDN--CLYYFEYTTDKEPRGIIPLENLSIREVEDPRKP 324
Query: 303 --------NSNGR-----KSEEENLFEIITADEVHYFLQAATPKERTEWIRAIQ 343
+ G+ K+E + ++ + V Y + A +P+E+ EW+++I+
Sbjct: 325 NCFELYNPSHKGQVIKACKTEADG--RVVEGNHVVYRISAPSPEEKEEWMKSIK 376
Score = 45.4 bits (106), Expect = 7e-05
Identities = 17/49 (34%), Positives = 32/49 (65%)
Query: 7 REGYLVKKGSVFNTWKPMWVVLLEDGIEFYKKKSDNSPKGMIPLKGSTL 55
REG+L+K G TWK W +L ++ + +++ +D P+G+IPL+ ++
Sbjct: 267 REGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSI 315
>gi|4758964 cytohesin 1 isoform 1 [Homo sapiens]
Length = 398
Score = 45.4 bits (106), Expect = 7e-05
Identities = 35/121 (28%), Positives = 55/121 (45%), Gaps = 30/121 (24%)
Query: 247 KQGCLLKQGHRR-KNWKVRKFILREDPAYLHYYDPAGAEDPLGAIHLRGCVVTSVESNSN 305
++G LLK G R K WK R FIL ++ L+Y++ ++P G I L + VE
Sbjct: 263 REGWLLKLGGGRVKTWKRRWFILTDN--CLYYFEYTTDKEPRGIIPLENLSIREVED--- 317
Query: 306 GRKSEEENLFE---------------------IITADEVHYFLQAATPKERTEWIRAIQM 344
S++ N FE ++ + Y + A TP+E+ EWI+ I+
Sbjct: 318 ---SKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEEWIKCIKA 374
Query: 345 A 345
A
Sbjct: 375 A 375
Score = 43.1 bits (100), Expect = 4e-04
Identities = 29/114 (25%), Positives = 49/114 (42%), Gaps = 20/114 (17%)
Query: 7 REGYLVKKGSV-FNTWKPMWVVLLEDGIEFYKKKSDNSPKGMIPLKGSTLTSPCQDFGKR 65
REG+L+K G TWK W +L ++ + +++ +D P+G+IPL+ ++
Sbjct: 263 REGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDSKKPN 322
Query: 66 MFVFKITTTKQQ-------------------DHFFQAAFLEERDAWVRDIKKAI 100
F I K Q + A EE++ W++ IK AI
Sbjct: 323 CFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEEWIKCIKAAI 376
>gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo
sapiens]
Length = 1054
Score = 45.4 bits (106), Expect = 7e-05
Identities = 28/92 (30%), Positives = 48/92 (52%), Gaps = 2/92 (2%)
Query: 9 GYLVKKGSVFNTWKPMWVVLLEDGIEFYKKKSDNSPKGMIPLKGSTLTSPCQDFG-KRMF 67
GYL++K + W+ +WVV + FYK D+ P +PL G +++ P + G + +
Sbjct: 934 GYLLRKFKNSHGWQKLWVVFTNFCLFFYKTHQDDYPLASLPLLGYSVSIPREADGIHKDY 993
Query: 68 VFKITTTKQQDHFFQAAFLEERDAWVRDIKKA 99
VFK+ K +FF+A + W+ I+ A
Sbjct: 994 VFKL-QFKSHVYFFRAESKYTFERWMEVIQGA 1024
>gi|55741447 pleckstrin homology domain containing, family H (with
MyTH4 domain) member 1 [Homo sapiens]
Length = 1364
Score = 45.1 bits (105), Expect = 1e-04
Identities = 30/98 (30%), Positives = 48/98 (48%), Gaps = 9/98 (9%)
Query: 7 REGYLVKKGSVFNTWKPMWVVLLEDGIEFYKKKSD--NSPKGMIPLKGSTLTSPCQDF-G 63
+ GYL+K GS TWK W VL + I +YK SD P+G + L S CQ G
Sbjct: 581 KSGYLLKMGSQVKTWKRRWFVLRQGQIMYYKSPSDVIRKPQGQV-----DLNSRCQIVRG 635
Query: 64 KRMFVFKITTTKQQDHFFQAAFLEERDAWVRDIKKAIK 101
+ F++ + K + ++ A + W+R ++ +K
Sbjct: 636 EGSQTFQLISEK-KTYYLTADSPSLLEEWIRVLQSLLK 672
Score = 43.9 bits (102), Expect = 2e-04
Identities = 31/99 (31%), Positives = 48/99 (48%), Gaps = 13/99 (13%)
Query: 247 KQGCLLKQGHRRKNWKVRKFILREDPAYLHYYDPAGA-EDPLGAIHLRG-CVVTSVESNS 304
K G LLK G + K WK R F+LR+ ++Y P+ P G + L C +
Sbjct: 581 KSGYLLKMGSQVKTWKRRWFVLRQG-QIMYYKSPSDVIRKPQGQVDLNSRCQIV------ 633
Query: 305 NGRKSEEENLFEIITADEVHYFLQAATPKERTEWIRAIQ 343
+ E F++I +++ Y+L A +P EWIR +Q
Sbjct: 634 ---RGEGSQTFQLI-SEKKTYYLTADSPSLLEEWIRVLQ 668
>gi|19923592 oxysterol binding protein-like 11 [Homo sapiens]
Length = 747
Score = 43.9 bits (102), Expect = 2e-04
Identities = 25/101 (24%), Positives = 47/101 (46%), Gaps = 10/101 (9%)
Query: 249 GCLLKQGHRRKNWKVRKFILREDPAYLHYY--DPAGAEDPLGAIHLRGCVVTSVESNSNG 306
G L+K + W+ R F+L + L Y+ + + + P G + L G V++ +
Sbjct: 63 GYLMKYTNLVTGWQYRFFVLNNEAGLLEYFVNEQSRNQKPRGTLQLAGAVISPSD----- 117
Query: 307 RKSEEENLFEIITADEVHYFLQAATPKERTEWIRAIQMASR 347
E+ + F + A Y L+A KER W+ +Q+ ++
Sbjct: 118 ---EDSHTFTVNAASGEQYKLRATDAKERQHWVSRLQICTQ 155
>gi|20070331 oxysterol binding protein-like 9 isoform e [Homo
sapiens]
Length = 736
Score = 43.1 bits (100), Expect = 4e-04
Identities = 31/101 (30%), Positives = 46/101 (45%), Gaps = 12/101 (11%)
Query: 246 IKQGCLLKQGHRRKNWKVRKFILREDPAYLHYY---DPAGAEDPLGAIHLRGCVVTSVES 302
I +G L K + K W+ R F+L + L YY D G + LRG V+
Sbjct: 4 IMEGPLSKWTNVMKGWQYRWFVLDYNAGLLSYYTSKDKMMRGSRRGCVRLRGAVI----- 58
Query: 303 NSNGRKSEEENLFEIITADEVHYFLQAATPKERTEWIRAIQ 343
G E+++ F I T D+ + QA ER +WI A++
Sbjct: 59 ---GIDDEDDSTFTI-TVDQKTFHFQARDADEREKWIHALE 95
Score = 36.2 bits (82), Expect = 0.045
Identities = 28/100 (28%), Positives = 47/100 (47%), Gaps = 10/100 (10%)
Query: 6 IREGYLVKKGSVFNTWKPMWVVLLEDG--IEFYKKKSD---NSPKGMIPLKGSTLTSPCQ 60
I EG L K +V W+ W VL + + +Y K S +G + L+G+ + +
Sbjct: 4 IMEGPLSKWTNVMKGWQYRWFVLDYNAGLLSYYTSKDKMMRGSRRGCVRLRGAVIGIDDE 63
Query: 61 DFGKRMFVFKITTTKQQDHFFQAAFLEERDAWVRDIKKAI 100
D F IT ++ HF QA +ER+ W+ +++ I
Sbjct: 64 DDS----TFTITVDQKTFHF-QARDADEREKWIHALEETI 98
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.136 0.411
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,605,968
Number of Sequences: 37866
Number of extensions: 610176
Number of successful extensions: 1756
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 89
Number of HSP's successfully gapped in prelim test: 75
Number of HSP's that attempted gapping in prelim test: 1498
Number of HSP's gapped (non-prelim): 284
length of query: 350
length of database: 18,247,518
effective HSP length: 103
effective length of query: 247
effective length of database: 14,347,320
effective search space: 3543788040
effective search space used: 3543788040
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.