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Search of human proteins with 110349799
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|110349799 testis-specific protein kinase 2 [Homo sapiens]
(571 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|110349799 testis-specific protein kinase 2 [Homo sapiens] 1163 0.0
gi|66932999 testis-specific protein kinase 1 [Homo sapiens] 446 e-125
gi|4505001 LIM domain kinase 1 [Homo sapiens] 228 9e-60
gi|8051618 LIM domain kinase 2 isoform 2b [Homo sapiens] 210 2e-54
gi|5031869 LIM domain kinase 2 isoform 2a [Homo sapiens] 210 2e-54
gi|73390140 LIM domain kinase 2 isoform 1 [Homo sapiens] 202 5e-52
gi|21735552 mitogen-activated protein kinase kinase kinase 12 [H... 119 1e-26
gi|47524175 fibroblast growth factor receptor 4 isoform 1 precur... 117 4e-26
gi|47524173 fibroblast growth factor receptor 4 isoform 1 precur... 117 4e-26
gi|47524177 fibroblast growth factor receptor 4 isoform 2 precur... 115 1e-25
gi|4503787 fyn-related kinase [Homo sapiens] 115 1e-25
gi|187475373 c-src tyrosine kinase [Homo sapiens] 113 4e-25
gi|4758078 c-src tyrosine kinase [Homo sapiens] 113 4e-25
gi|57242761 receptor (TNFRSF)-interacting serine-threonine kinas... 113 5e-25
gi|21536468 AXL receptor tyrosine kinase isoform 2 [Homo sapiens] 112 1e-24
gi|21536466 AXL receptor tyrosine kinase isoform 1 [Homo sapiens] 112 1e-24
gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Ho... 112 1e-24
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo... 111 2e-24
gi|66932918 MER receptor tyrosine kinase precursor [Homo sapiens] 110 3e-24
gi|21361358 serine/threonine kinase 25 [Homo sapiens] 110 3e-24
gi|103471999 serine/threonine kinase 3 [Homo sapiens] 110 5e-24
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 110 5e-24
gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens] 108 1e-23
gi|4758696 mitogen-activated protein kinase kinase kinase 13 [Ho... 108 1e-23
gi|4758284 ephrin receptor EphB1 precursor [Homo sapiens] 107 3e-23
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 107 4e-23
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 107 4e-23
gi|219842236 feline sarcoma oncogene isoform 4 [Homo sapiens] 106 5e-23
gi|219842233 feline sarcoma oncogene isoform 3 [Homo sapiens] 106 5e-23
gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens] 106 5e-23
>gi|110349799 testis-specific protein kinase 2 [Homo sapiens]
Length = 571
Score = 1163 bits (3009), Expect = 0.0
Identities = 571/571 (100%), Positives = 571/571 (100%)
Query: 1 MDRSKRNSIAGFPPRVERLEEFEGGGGGEGNVSQVGRVWPSSYRALISAFSRLTRLDDFT 60
MDRSKRNSIAGFPPRVERLEEFEGGGGGEGNVSQVGRVWPSSYRALISAFSRLTRLDDFT
Sbjct: 1 MDRSKRNSIAGFPPRVERLEEFEGGGGGEGNVSQVGRVWPSSYRALISAFSRLTRLDDFT 60
Query: 61 CEKIGSGFFSEVFKVRHRASGQVMALKMNTLSSNRANMLKEVQLMNRLSHPNILRFMGVC 120
CEKIGSGFFSEVFKVRHRASGQVMALKMNTLSSNRANMLKEVQLMNRLSHPNILRFMGVC
Sbjct: 61 CEKIGSGFFSEVFKVRHRASGQVMALKMNTLSSNRANMLKEVQLMNRLSHPNILRFMGVC 120
Query: 121 VHQGQLHALTEYINSGNLEQLLDSNLHLPWTVRVKLAYDIAVGLSYLHFKGIFHRDLTSK 180
VHQGQLHALTEYINSGNLEQLLDSNLHLPWTVRVKLAYDIAVGLSYLHFKGIFHRDLTSK
Sbjct: 121 VHQGQLHALTEYINSGNLEQLLDSNLHLPWTVRVKLAYDIAVGLSYLHFKGIFHRDLTSK 180
Query: 181 NCLIKRDENGYSAVVADFGLAEKIPDVSMGSEKLAVVGSPFWMAPEVLRDEPYNEKADVF 240
NCLIKRDENGYSAVVADFGLAEKIPDVSMGSEKLAVVGSPFWMAPEVLRDEPYNEKADVF
Sbjct: 181 NCLIKRDENGYSAVVADFGLAEKIPDVSMGSEKLAVVGSPFWMAPEVLRDEPYNEKADVF 240
Query: 241 SYGIILCEIIARIQADPDYLPRTENFGLDYDAFQHMVGDCPPDFLQLTFNCCNMDPKLRP 300
SYGIILCEIIARIQADPDYLPRTENFGLDYDAFQHMVGDCPPDFLQLTFNCCNMDPKLRP
Sbjct: 241 SYGIILCEIIARIQADPDYLPRTENFGLDYDAFQHMVGDCPPDFLQLTFNCCNMDPKLRP 300
Query: 301 SFVEIGKTLEEILSRLQEEEQERDRKLQPTARGLLEKAPGVKRLSSLDDKIPHKSPCPRR 360
SFVEIGKTLEEILSRLQEEEQERDRKLQPTARGLLEKAPGVKRLSSLDDKIPHKSPCPRR
Sbjct: 301 SFVEIGKTLEEILSRLQEEEQERDRKLQPTARGLLEKAPGVKRLSSLDDKIPHKSPCPRR 360
Query: 361 TIWLSRSQSDIFSRKPPRTVSVLDPYYRPRDGAARTPKVNPFSARQDLMGGKIKFFDLPS 420
TIWLSRSQSDIFSRKPPRTVSVLDPYYRPRDGAARTPKVNPFSARQDLMGGKIKFFDLPS
Sbjct: 361 TIWLSRSQSDIFSRKPPRTVSVLDPYYRPRDGAARTPKVNPFSARQDLMGGKIKFFDLPS 420
Query: 421 KSVISLVFDLDAPGPGTMPLADWQEPLAPPIRRWRSLPGSPEFLHQEACPFVGREESLSD 480
KSVISLVFDLDAPGPGTMPLADWQEPLAPPIRRWRSLPGSPEFLHQEACPFVGREESLSD
Sbjct: 421 KSVISLVFDLDAPGPGTMPLADWQEPLAPPIRRWRSLPGSPEFLHQEACPFVGREESLSD 480
Query: 481 GPPPRLSSLKYRVKEIPPFRASALPAAQAHEAMDCSILQEENGFGSRPQGTSPCPAGASE 540
GPPPRLSSLKYRVKEIPPFRASALPAAQAHEAMDCSILQEENGFGSRPQGTSPCPAGASE
Sbjct: 481 GPPPRLSSLKYRVKEIPPFRASALPAAQAHEAMDCSILQEENGFGSRPQGTSPCPAGASE 540
Query: 541 EMEVEERPAGSTPATFSTSGIGLQTQGKQDG 571
EMEVEERPAGSTPATFSTSGIGLQTQGKQDG
Sbjct: 541 EMEVEERPAGSTPATFSTSGIGLQTQGKQDG 571
>gi|66932999 testis-specific protein kinase 1 [Homo sapiens]
Length = 626
Score = 446 bits (1146), Expect = e-125
Identities = 274/524 (52%), Positives = 316/524 (60%), Gaps = 71/524 (13%)
Query: 23 EGGGGGEGNVSQVGRVWPSSYRALISAFSRLTRLDDFTC-EKIGSGFFSEVFKVRHRASG 81
EG G G GR PSSYRAL SA S L R+DDF C EKIG+GFFSEV+KVRHR SG
Sbjct: 21 EGPPGPGGTGGGPGRGRPSSYRALRSAVSSLARVDDFHCAEKIGAGFFSEVYKVRHRQSG 80
Query: 82 QVMALKMNTLSSNRANMLKEVQLMNRLSHPNILRFMGVCVHQGQLHALTEYINSGNLEQL 141
QVM LKMN L SNR N L+EVQLMNRL HPNILRFMGVCVHQGQLHALTEY+N G LEQL
Sbjct: 81 QVMVLKMNKLPSNRGNTLREVQLMNRLRHPNILRFMGVCVHQGQLHALTEYMNGGTLEQL 140
Query: 142 LDSNLHLPWTVRVKLAYDIAVGLSYLHFKGIFHRDLTSKNCLIKRDENGYSAVVADFGLA 201
L S L W VR+ LA DIA GL YLH KG+FHRDLTSKNCL++R++ G++AVV DFGLA
Sbjct: 141 LSSPEPLSWPVRLHLALDIARGLRYLHSKGVFHRDLTSKNCLVRREDRGFTAVVGDFGLA 200
Query: 202 EKIPDVSMGSEK--LAVVGSPFWMAPEVLRDEPYNEKADVFSYGIILCEIIARIQADPDY 259
EKIP G+ K LAVVGSP+WMAPEVLR E Y+EKADVF++GI+LCE+IAR+ ADPDY
Sbjct: 201 EKIPVYREGARKEPLAVVGSPYWMAPEVLRGELYDEKADVFAFGIVLCELIARVPADPDY 260
Query: 260 LPRTENFGLDYDAFQHMVG-DCPPDFLQLTFNCCNMDPKLRPSFVEIGKTLEEILSRLQE 318
LPRTE+FGLD AF+ +VG DCP FL L +CCN++P R F EI + LE IL +L E
Sbjct: 261 LPRTEDFGLDVPAFRTLVGDDCPLPFLLLAIHCCNLEPSTRAPFTEITQHLEWILEQLPE 320
Query: 319 EEQERDRKLQPTARGLLEKAPGVKRLSSLDDKIPHKSPCPRRTIWLSRSQSDIFSRKPPR 378
P R L G +P P PR LSRS+SD+F P
Sbjct: 321 P--------APLTRTALTHNQGSVARGGPSATLPR--PDPR----LSRSRSDLFLPPSPE 366
Query: 379 TVSVLDPYYRPRDGAARTPKVNPFSARQDLMGGKIKFFDLPSKSVISLVFDLDAPGPGT- 437
+ P + +VNPFS R+DL GGKIK D PSK V+ LV +P P T
Sbjct: 367 S---------PPNWGDNLTRVNPFSLREDLRGGKIKLLDTPSKPVLPLV--PPSPFPSTQ 415
Query: 438 MPLADWQEPL---APPIRRWRSLPGSPEFLHQEACPFVGREESLSDGPPPRLSSLKYRVK 494
+PL E L P RR RSLP SPE R E+ GP P
Sbjct: 416 LPLVTTPETLVQPGTPARRCRSLPSSPELPR--------RMETALPGPGP---------- 457
Query: 495 EIPPFRASALPAA--QAHEAMDCSILQEENGFGSRPQGTSPCPA 536
PA A E M+C GS P+ P PA
Sbjct: 458 ----------PAVGPSAEEKMECE--------GSSPEPEPPGPA 483
>gi|4505001 LIM domain kinase 1 [Homo sapiens]
Length = 647
Score = 228 bits (582), Expect = 9e-60
Identities = 120/272 (44%), Positives = 166/272 (61%), Gaps = 20/272 (7%)
Query: 62 EKIGSGFFSEVFKVRHRASGQVMALK--MNTLSSNRANMLKEVQLMNRLSHPNILRFMGV 119
E +G G F + KV HR +G+VM +K + + LKEV++M L HPN+L+F+GV
Sbjct: 343 EVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGV 402
Query: 120 CVHQGQLHALTEYINSGNLEQLLDS-NLHLPWTVRVKLAYDIAVGLSYLHFKGIFHRDLT 178
+L+ +TEYI G L ++ S + PW+ RV A DIA G++YLH I HRDL
Sbjct: 403 LYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLN 462
Query: 179 SKNCLIKRDENGYSAVVADFGLAEKIPDVSMGSEKL------------AVVGSPFWMAPE 226
S NCL++ ++N VVADFGLA + D E L VVG+P+WMAPE
Sbjct: 463 SHNCLVRENKN---VVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPE 519
Query: 227 VLRDEPYNEKADVFSYGIILCEIIARIQADPDYLPRTENFGLDYDAF--QHMVGDCPPDF 284
++ Y+EK DVFS+GI+LCEII R+ ADPDYLPRT +FGL+ F ++ +CPP F
Sbjct: 520 MINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSF 579
Query: 285 LQLTFNCCNMDPKLRPSFVEIGKTLEEILSRL 316
+T CC++DP+ RPSFV++ LE + L
Sbjct: 580 FPITVRCCDLDPEKRPSFVKLEHWLETLRMHL 611
>gi|8051618 LIM domain kinase 2 isoform 2b [Homo sapiens]
Length = 617
Score = 210 bits (535), Expect = 2e-54
Identities = 114/279 (40%), Positives = 163/279 (58%), Gaps = 25/279 (8%)
Query: 62 EKIGSGFFSEVFKVRHRASGQVMALK--MNTLSSNRANMLKEVQLMNRLSHPNILRFMGV 119
E +G GFF + KV H+A+G+VM +K + + L EV++M L HPN+L+F+GV
Sbjct: 314 EVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGV 373
Query: 120 CVHQGQLHALTEYINSGNLEQLLDSNLHLPWTVRVKLAYDIAVGLSYLHFKGIFHRDLTS 179
+L+ LTEYI G L+ L S PW +V+ A IA G++YLH I HRDL S
Sbjct: 374 LYKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSMCIIHRDLNS 433
Query: 180 KNCLIKRDENGYSAVVADFGLAEKIPDVSMGS------------------EKLAVVGSPF 221
NCLIK D+ + VVADFGL+ I + + ++ VVG+P+
Sbjct: 434 HNCLIKLDK---TVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNPY 490
Query: 222 WMAPEVLRDEPYNEKADVFSYGIILCEIIARIQADPDYLPRTENFGLDYDAF--QHMVGD 279
WMAPE+L + Y+E D+FS+GI+LCEII ++ ADPD LPRT +FGL+ F + + D
Sbjct: 491 WMAPEMLNGKSYDETVDIFSFGIVLCEIIGQVYADPDCLPRTLDFGLNVKLFWEKFVPTD 550
Query: 280 CPPDFLQLTFNCCNMDPKLRPSFVEIGKTLEEILSRLQE 318
CPP F L CC ++P+ RP+F ++ + E + L E
Sbjct: 551 CPPAFFPLAAICCRLEPESRPAFSKLEDSFEALSLYLGE 589
>gi|5031869 LIM domain kinase 2 isoform 2a [Homo sapiens]
Length = 638
Score = 210 bits (535), Expect = 2e-54
Identities = 114/279 (40%), Positives = 163/279 (58%), Gaps = 25/279 (8%)
Query: 62 EKIGSGFFSEVFKVRHRASGQVMALK--MNTLSSNRANMLKEVQLMNRLSHPNILRFMGV 119
E +G GFF + KV H+A+G+VM +K + + L EV++M L HPN+L+F+GV
Sbjct: 335 EVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGV 394
Query: 120 CVHQGQLHALTEYINSGNLEQLLDSNLHLPWTVRVKLAYDIAVGLSYLHFKGIFHRDLTS 179
+L+ LTEYI G L+ L S PW +V+ A IA G++YLH I HRDL S
Sbjct: 395 LYKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSMCIIHRDLNS 454
Query: 180 KNCLIKRDENGYSAVVADFGLAEKIPDVSMGS------------------EKLAVVGSPF 221
NCLIK D+ + VVADFGL+ I + + ++ VVG+P+
Sbjct: 455 HNCLIKLDK---TVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNPY 511
Query: 222 WMAPEVLRDEPYNEKADVFSYGIILCEIIARIQADPDYLPRTENFGLDYDAF--QHMVGD 279
WMAPE+L + Y+E D+FS+GI+LCEII ++ ADPD LPRT +FGL+ F + + D
Sbjct: 512 WMAPEMLNGKSYDETVDIFSFGIVLCEIIGQVYADPDCLPRTLDFGLNVKLFWEKFVPTD 571
Query: 280 CPPDFLQLTFNCCNMDPKLRPSFVEIGKTLEEILSRLQE 318
CPP F L CC ++P+ RP+F ++ + E + L E
Sbjct: 572 CPPAFFPLAAICCRLEPESRPAFSKLEDSFEALSLYLGE 610
>gi|73390140 LIM domain kinase 2 isoform 1 [Homo sapiens]
Length = 686
Score = 202 bits (515), Expect = 5e-52
Identities = 109/260 (41%), Positives = 153/260 (58%), Gaps = 25/260 (9%)
Query: 62 EKIGSGFFSEVFKVRHRASGQVMALK--MNTLSSNRANMLKEVQLMNRLSHPNILRFMGV 119
E +G GFF + KV H+A+G+VM +K + + L EV++M L HPN+L+F+GV
Sbjct: 314 EVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGV 373
Query: 120 CVHQGQLHALTEYINSGNLEQLLDSNLHLPWTVRVKLAYDIAVGLSYLHFKGIFHRDLTS 179
+L+ LTEYI G L+ L S PW +V+ A IA G++YLH I HRDL S
Sbjct: 374 LYKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSMCIIHRDLNS 433
Query: 180 KNCLIKRDENGYSAVVADFGLAEKIPDVSMGS------------------EKLAVVGSPF 221
NCLIK D+ + VVADFGL+ I + + ++ VVG+P+
Sbjct: 434 HNCLIKLDK---TVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNPY 490
Query: 222 WMAPEVLRDEPYNEKADVFSYGIILCEIIARIQADPDYLPRTENFGLDYDAF--QHMVGD 279
WMAPE+L + Y+E D+FS+GI+LCEII ++ ADPD LPRT +FGL+ F + + D
Sbjct: 491 WMAPEMLNGKSYDETVDIFSFGIVLCEIIGQVYADPDCLPRTLDFGLNVKLFWEKFVPTD 550
Query: 280 CPPDFLQLTFNCCNMDPKLR 299
CPP F L CC ++P+ R
Sbjct: 551 CPPAFFPLAAICCRLEPESR 570
>gi|21735552 mitogen-activated protein kinase kinase kinase 12 [Homo
sapiens]
Length = 859
Score = 119 bits (297), Expect = 1e-26
Identities = 86/262 (32%), Positives = 134/262 (51%), Gaps = 22/262 (8%)
Query: 64 IGSGFFSEVFKVRHRASGQVMALKMNTLSSNRANMLKEVQL--MNRLSHPNILRFMGVCV 121
+GSG VF R G+ +A+K + LKE + + +L HPNI+ F GVC
Sbjct: 131 VGSGAQGAVFLGRFH--GEEVAVK-------KVRDLKETDIKHLRKLKHPNIITFKGVCT 181
Query: 122 HQGQLHALTEYINSGNLEQLLDSNLHLPWTVRVKLAYDIAVGLSYLHFKGIFHRDLTSKN 181
L E+ G L ++L + + ++ V + IA G++YLH I HRDL S N
Sbjct: 182 QAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPN 241
Query: 182 CLIKRDENGYSAVVADFGLAEKIPDVSMGSEKLAVVGSPFWMAPEVLRDEPYNEKADVFS 241
LI D+ ++DFG ++++ D S K++ G+ WMAPEV+R+EP +EK D++S
Sbjct: 242 MLITYDD---VVKISDFGTSKELSD---KSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWS 295
Query: 242 YGIILCEIIARIQADPDYLPRTENFGLDYDAFQHMV-GDCPPDFLQLTFNCCNMDPKLRP 300
+G++L E++ D +G+ ++ V CP F L C N P+ RP
Sbjct: 296 FGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRP 355
Query: 301 SFVEIGKTLE----EILSRLQE 318
SF +I L+ ++LS QE
Sbjct: 356 SFRQILLHLDIASADVLSTPQE 377
>gi|47524175 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 117 bits (292), Expect = 4e-26
Identities = 100/356 (28%), Positives = 155/356 (43%), Gaps = 54/356 (15%)
Query: 13 PPRVERLEEF--------EGGGGGEGNVSQVGRV-----WPSSYRALISAFSRLTRLDDF 59
P V++L F E G G+ + S V V P+ L+S L L +F
Sbjct: 403 PATVQKLSRFPLARQFSLESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEF 462
Query: 60 TCEKI------GSGFFSEVFKVRHRASGQ------------VMALKMNTLSSNRANMLKE 101
+++ G G F +V VR A G V LK N + A+++ E
Sbjct: 463 PRDRLVLGKPLGEGCFGQV--VRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSE 520
Query: 102 VQLMNRLS-HPNILRFMGVCVHQGQLHALTEYINSGNLEQLL----------------DS 144
+++M + H NI+ +GVC +G L+ + E GNL + L S
Sbjct: 521 MEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSS 580
Query: 145 NLHLPWTVRVKLAYDIAVGLSYLHFKGIFHRDLTSKNCLIKRDENGYSAVVADFGLAEKI 204
L + V V AY +A G+ YL + HRDL ++N L+ D +ADFGLA +
Sbjct: 581 EGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDN---VMKIADFGLARGV 637
Query: 205 PDVSMGSEKLAVVGSPFWMAPEVLRDEPYNEKADVFSYGIILCEIIARIQADPDYLPRTE 264
+ + WMAPE L D Y ++DV+S+GI+L EI + +P E
Sbjct: 638 HHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEE 697
Query: 265 NFGLDYDAFQ-HMVGDCPPDFLQLTFNCCNMDPKLRPSFVEIGKTLEEILSRLQEE 319
F L + + CPP+ L C + P RP+F ++ + L+++L + EE
Sbjct: 698 LFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEE 753
>gi|47524173 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 117 bits (292), Expect = 4e-26
Identities = 100/356 (28%), Positives = 155/356 (43%), Gaps = 54/356 (15%)
Query: 13 PPRVERLEEF--------EGGGGGEGNVSQVGRV-----WPSSYRALISAFSRLTRLDDF 59
P V++L F E G G+ + S V V P+ L+S L L +F
Sbjct: 403 PATVQKLSRFPLARQFSLESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEF 462
Query: 60 TCEKI------GSGFFSEVFKVRHRASGQ------------VMALKMNTLSSNRANMLKE 101
+++ G G F +V VR A G V LK N + A+++ E
Sbjct: 463 PRDRLVLGKPLGEGCFGQV--VRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSE 520
Query: 102 VQLMNRLS-HPNILRFMGVCVHQGQLHALTEYINSGNLEQLL----------------DS 144
+++M + H NI+ +GVC +G L+ + E GNL + L S
Sbjct: 521 MEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSS 580
Query: 145 NLHLPWTVRVKLAYDIAVGLSYLHFKGIFHRDLTSKNCLIKRDENGYSAVVADFGLAEKI 204
L + V V AY +A G+ YL + HRDL ++N L+ D +ADFGLA +
Sbjct: 581 EGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDN---VMKIADFGLARGV 637
Query: 205 PDVSMGSEKLAVVGSPFWMAPEVLRDEPYNEKADVFSYGIILCEIIARIQADPDYLPRTE 264
+ + WMAPE L D Y ++DV+S+GI+L EI + +P E
Sbjct: 638 HHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEE 697
Query: 265 NFGLDYDAFQ-HMVGDCPPDFLQLTFNCCNMDPKLRPSFVEIGKTLEEILSRLQEE 319
F L + + CPP+ L C + P RP+F ++ + L+++L + EE
Sbjct: 698 LFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEE 753
>gi|47524177 fibroblast growth factor receptor 4 isoform 2 precursor
[Homo sapiens]
Length = 762
Score = 115 bits (288), Expect = 1e-25
Identities = 96/338 (28%), Positives = 149/338 (44%), Gaps = 46/338 (13%)
Query: 23 EGGGGGEGNVSQVGRV-----WPSSYRALISAFSRLTRLDDFTCEKI------GSGFFSE 71
E G G+ + S V V P+ L+S L L +F +++ G G F +
Sbjct: 381 ESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQ 440
Query: 72 VFKVRHRASGQ------------VMALKMNTLSSNRANMLKEVQLMNRLS-HPNILRFMG 118
V VR A G V LK N + A+++ E+++M + H NI+ +G
Sbjct: 441 V--VRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLG 498
Query: 119 VCVHQGQLHALTEYINSGNLEQLL----------------DSNLHLPWTVRVKLAYDIAV 162
VC +G L+ + E GNL + L S L + V V AY +A
Sbjct: 499 VCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVAR 558
Query: 163 GLSYLHFKGIFHRDLTSKNCLIKRDENGYSAVVADFGLAEKIPDVSMGSEKLAVVGSPFW 222
G+ YL + HRDL ++N L+ D +ADFGLA + + + W
Sbjct: 559 GMQYLESRKCIHRDLAARNVLVTEDN---VMKIADFGLARGVHHIDYYKKTSNGRLPVKW 615
Query: 223 MAPEVLRDEPYNEKADVFSYGIILCEIIARIQADPDYLPRTENFGLDYDAFQ-HMVGDCP 281
MAPE L D Y ++DV+S+GI+L EI + +P E F L + + CP
Sbjct: 616 MAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCP 675
Query: 282 PDFLQLTFNCCNMDPKLRPSFVEIGKTLEEILSRLQEE 319
P+ L C + P RP+F ++ + L+++L + EE
Sbjct: 676 PELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEE 713
>gi|4503787 fyn-related kinase [Homo sapiens]
Length = 505
Score = 115 bits (287), Expect = 1e-25
Identities = 75/257 (29%), Positives = 132/257 (51%), Gaps = 12/257 (4%)
Query: 62 EKIGSGFFSEVFKVRHRASGQVMALKMNTLSSNRANMLKEVQLMNRLSHPNILRFMGVCV 121
+++GSG F EV++ + V + S + + L+E Q+M L HP +++ VC
Sbjct: 238 KRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLYAVCT 297
Query: 122 HQGQLHALTEYINSGNLEQLLD----SNLHLPWTVRVKLAYDIAVGLSYLHFKGIFHRDL 177
+ ++ +TE + G+L++ L S +HL T +V +A +A G++YL + HRDL
Sbjct: 298 LEDPIYIITELMRHGSLQEYLQNDTGSKIHL--TQQVDMAAQVASGMAYLESRNYIHRDL 355
Query: 178 TSKNCLIKRDENGYSAVVADFGLAE--KIPDVSMGSEKLAVVGSPFWMAPEVLRDEPYNE 235
++N L+ + N Y VADFGLA K+ + + + + W APE +R ++
Sbjct: 356 AARNVLV-GEHNIYK--VADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSI 412
Query: 236 KADVFSYGIILCEIIARIQADPDYLPRTENFGLDYDAFQ-HMVGDCPPDFLQLTFNCCNM 294
K+DV+S+GI+L EII + + + + ++ +CP F + C N
Sbjct: 413 KSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWNA 472
Query: 295 DPKLRPSFVEIGKTLEE 311
+PK RP+F + LE+
Sbjct: 473 EPKERPTFETLRWKLED 489
>gi|187475373 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 113 bits (283), Expect = 4e-25
Identities = 85/261 (32%), Positives = 133/261 (50%), Gaps = 26/261 (9%)
Query: 62 EKIGSGFFSEVFKVRHRASGQVMALKMNTLSSNRANMLKEVQLMNRLSHPNILRFMGVCV 121
+ IG G F +V +R G +A+K + L E +M +L H N+++ +GV V
Sbjct: 199 QTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIV 256
Query: 122 HQ-GQLHALTEYINSGNLEQLLDSNLH--LPWTVRVKLAYDIAVGLSYLHFKGIFHRDLT 178
+ G L+ +TEY+ G+L L S L +K + D+ + YL HRDL
Sbjct: 257 EEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLA 316
Query: 179 SKNCLIKRDENGYSAVVADFGLAEKIPDVSMGSEKLAVVGSPFWMAPEVLRDEPYNEKAD 238
++N L+ D A V+DFGL ++ + + KL V W APE LR++ ++ K+D
Sbjct: 317 ARNVLVSEDN---VAKVSDFGLTKEASS-TQDTGKLPVK----WTAPEALREKKFSTKSD 368
Query: 239 VFSYGIILCEIIA-------RIQADPDYLPRTENFGLDYDAFQHMVGDCPPDFLQLTFNC 291
V+S+GI+L EI + RI D +PR E G DA CPP ++ NC
Sbjct: 369 VWSFGILLWEIYSFGRVPYPRIPL-KDVVPRVEK-GYKMDA----PDGCPPAVYEVMKNC 422
Query: 292 CNMDPKLRPSFVEIGKTLEEI 312
++D +RPSF+++ + LE I
Sbjct: 423 WHLDAAMRPSFLQLREQLEHI 443
>gi|4758078 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 113 bits (283), Expect = 4e-25
Identities = 85/261 (32%), Positives = 133/261 (50%), Gaps = 26/261 (9%)
Query: 62 EKIGSGFFSEVFKVRHRASGQVMALKMNTLSSNRANMLKEVQLMNRLSHPNILRFMGVCV 121
+ IG G F +V +R G +A+K + L E +M +L H N+++ +GV V
Sbjct: 199 QTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIV 256
Query: 122 HQ-GQLHALTEYINSGNLEQLLDSNLH--LPWTVRVKLAYDIAVGLSYLHFKGIFHRDLT 178
+ G L+ +TEY+ G+L L S L +K + D+ + YL HRDL
Sbjct: 257 EEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLA 316
Query: 179 SKNCLIKRDENGYSAVVADFGLAEKIPDVSMGSEKLAVVGSPFWMAPEVLRDEPYNEKAD 238
++N L+ D A V+DFGL ++ + + KL V W APE LR++ ++ K+D
Sbjct: 317 ARNVLVSEDN---VAKVSDFGLTKEASS-TQDTGKLPVK----WTAPEALREKKFSTKSD 368
Query: 239 VFSYGIILCEIIA-------RIQADPDYLPRTENFGLDYDAFQHMVGDCPPDFLQLTFNC 291
V+S+GI+L EI + RI D +PR E G DA CPP ++ NC
Sbjct: 369 VWSFGILLWEIYSFGRVPYPRIPL-KDVVPRVEK-GYKMDA----PDGCPPAVYEVMKNC 422
Query: 292 CNMDPKLRPSFVEIGKTLEEI 312
++D +RPSF+++ + LE I
Sbjct: 423 WHLDAAMRPSFLQLREQLEHI 443
>gi|57242761 receptor (TNFRSF)-interacting serine-threonine kinase 1
[Homo sapiens]
Length = 671
Score = 113 bits (282), Expect = 5e-25
Identities = 87/310 (28%), Positives = 154/310 (49%), Gaps = 35/310 (11%)
Query: 63 KIGSGFFSEVFKVRHRASGQVMALKM-----NTLSSNRANMLKEVQLMNRLSHPNILRFM 117
++ SG F +V HR G +M +K N + N A +L+E ++MNRL H +++ +
Sbjct: 22 ELDSGGFGKVSLCFHRTQG-LMIMKTVYKGPNCIEHNEA-LLEEAKMMNRLRHSRVVKLL 79
Query: 118 GVCVHQGQLHALTEYINSGNLEQLLDSNLHLPWTVRVKLAYDIAVGLSYLHFKGIFHRDL 177
GV + +G+ + EY+ GNL +L + + P +V+ ++ +I G+ YLH KG+ H+DL
Sbjct: 80 GVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGKGVIHKDL 139
Query: 178 TSKNCLIKRDENGYSAVVADFGLA-------------EKIPDVSMGSEKLAVVGSPFWMA 224
+N L+ +N + +AD GLA ++ +V ++K G+ ++MA
Sbjct: 140 KPENILV---DNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNG--GTLYYMA 194
Query: 225 PEVLRD--EPYNEKADVFSYGIILCEIIARIQADPDYLPRTENFGLDYDAFQHMVGD--- 279
PE L D EK+DV+S+ ++L I A + + + + + V D
Sbjct: 195 PEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNRPDVDDITE 254
Query: 280 -CPPDFLQLTFNCCNMDPKLRPSFVEIGKTLEEI-LSRLQEEEQERDRKLQPTARGLLEK 337
CP + + L C +P+ RP+F I + LS+L+E +E + L+ + +
Sbjct: 255 YCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEEDVKSLK---KEYSNE 311
Query: 338 APGVKRLSSL 347
VKR+ SL
Sbjct: 312 NAVVKRMQSL 321
>gi|21536468 AXL receptor tyrosine kinase isoform 2 [Homo sapiens]
Length = 885
Score = 112 bits (279), Expect = 1e-24
Identities = 80/281 (28%), Positives = 126/281 (44%), Gaps = 30/281 (10%)
Query: 64 IGSGFFSEVFKVRHRASGQVMALKMNTLS------SNRANMLKEVQLMNRLSHPNILRFM 117
+G G F V + + ++ + + T+ S + L E M HPN++R +
Sbjct: 533 LGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLI 592
Query: 118 GVCVHQGQLHA------LTEYINSGNLEQLL------DSNLHLPWTVRVKLAYDIAVGLS 165
GVC + + + ++ G+L L D ++LP + VK DIA G+
Sbjct: 593 GVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGME 652
Query: 166 YLHFKGIFHRDLTSKNCLIKRDENGYSAVVADFGLAEKIPDVSMGSEKLAVVGSPFWMAP 225
YL K HRDL ++NC++ + S VADFGL++KI + + W+A
Sbjct: 653 YLSTKRFIHRDLAARNCMLNEN---MSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAI 709
Query: 226 EVLRDEPYNEKADVFSYGIILCEIIARIQADPDYLPRTENFGLDYDAFQH-----MVGDC 280
E L D Y K+DV+S+G+ + EI R Q P EN + YD + DC
Sbjct: 710 ESLADRVYTSKSDVWSFGVTMWEIATRGQTP---YPGVENSEI-YDYLRQGNRLKQPADC 765
Query: 281 PPDFLQLTFNCCNMDPKLRPSFVEIGKTLEEILSRLQEEEQ 321
L C ++P+ RPSF E+ + LE L L ++
Sbjct: 766 LDGLYALMSRCWELNPQDRPSFTELREDLENTLKALPPAQE 806
>gi|21536466 AXL receptor tyrosine kinase isoform 1 [Homo sapiens]
Length = 894
Score = 112 bits (279), Expect = 1e-24
Identities = 80/281 (28%), Positives = 126/281 (44%), Gaps = 30/281 (10%)
Query: 64 IGSGFFSEVFKVRHRASGQVMALKMNTLS------SNRANMLKEVQLMNRLSHPNILRFM 117
+G G F V + + ++ + + T+ S + L E M HPN++R +
Sbjct: 542 LGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLI 601
Query: 118 GVCVHQGQLHA------LTEYINSGNLEQLL------DSNLHLPWTVRVKLAYDIAVGLS 165
GVC + + + ++ G+L L D ++LP + VK DIA G+
Sbjct: 602 GVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGME 661
Query: 166 YLHFKGIFHRDLTSKNCLIKRDENGYSAVVADFGLAEKIPDVSMGSEKLAVVGSPFWMAP 225
YL K HRDL ++NC++ + S VADFGL++KI + + W+A
Sbjct: 662 YLSTKRFIHRDLAARNCMLNEN---MSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAI 718
Query: 226 EVLRDEPYNEKADVFSYGIILCEIIARIQADPDYLPRTENFGLDYDAFQH-----MVGDC 280
E L D Y K+DV+S+G+ + EI R Q P EN + YD + DC
Sbjct: 719 ESLADRVYTSKSDVWSFGVTMWEIATRGQTP---YPGVENSEI-YDYLRQGNRLKQPADC 774
Query: 281 PPDFLQLTFNCCNMDPKLRPSFVEIGKTLEEILSRLQEEEQ 321
L C ++P+ RPSF E+ + LE L L ++
Sbjct: 775 LDGLYALMSRCWELNPQDRPSFTELREDLENTLKALPPAQE 815
>gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Homo
sapiens]
Length = 1118
Score = 112 bits (279), Expect = 1e-24
Identities = 96/314 (30%), Positives = 151/314 (48%), Gaps = 41/314 (13%)
Query: 26 GGGEGNVSQVGRVWPSSYRALISAFS----------------RLTRLD--DFTCEKI-GS 66
G G ++Q ++PS+Y SAFS +L +D + T E+I G
Sbjct: 93 GWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGI 152
Query: 67 GFFSEVFKVRHRASGQVMALKM------NTLSSNRANMLKEVQLMNRLSHPNILRFMGVC 120
G F +V++ G +A+K +S N+ +E +L L HPNI+ GVC
Sbjct: 153 GGFGKVYRAFW--IGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVC 210
Query: 121 VHQGQLHALTEYINSGNLEQLLDSNLHLPWTVRVKLAYDIAVGLSYLHFKGI---FHRDL 177
+ + L + E+ G L ++L S +P + V A IA G++YLH + I HRDL
Sbjct: 211 LKEPNLCLVMEFARGGPLNRVL-SGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDL 269
Query: 178 TSKNCLI-KRDENGYSA----VVADFGLAEKIPDVSMGSEKLAVVGSPFWMAPEVLRDEP 232
S N LI ++ ENG + + DFGLA + + K++ G+ WMAPEV+R
Sbjct: 270 KSSNILILQKVENGDLSNKILKITDFGLAREWHRTT----KMSAAGTYAWMAPEVIRASM 325
Query: 233 YNEKADVFSYGIILCEIIARIQADPDYLPRTENFGLDYDAFQHMV-GDCPPDFLQLTFNC 291
+++ +DV+SYG++L E++ +G+ + + CP F +L +C
Sbjct: 326 FSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDC 385
Query: 292 CNMDPKLRPSFVEI 305
N DP RPSF I
Sbjct: 386 WNPDPHSRPSFTNI 399
>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
sapiens]
Length = 416
Score = 111 bits (278), Expect = 2e-24
Identities = 75/249 (30%), Positives = 125/249 (50%), Gaps = 9/249 (3%)
Query: 62 EKIGSGFFSEVFKVRHRASGQVMALKMNTLSSNR---ANMLKEVQLMNRLSHPNILRFMG 118
E+IG G F EVFK + QV+A+K+ L ++ +E+ ++++ + ++ G
Sbjct: 28 ERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVTKYYG 87
Query: 119 VCVHQGQLHALTEYINSGNLEQLLDSNLHLPWTVRVKLAYDIAVGLSYLHFKGIFHRDLT 178
+ +L + EY+ G+ LL + + + L +I GL YLH + HRD+
Sbjct: 88 SYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLK-EILKGLDYLHSEKKIHRDIK 146
Query: 179 SKNCLIKRDENGYSAVVADFGLAEKIPDVSMGSEKLAVVGSPFWMAPEVLRDEPYNEKAD 238
+ N L+ E G +ADFG+A ++ D + ++ VG+PFWMAPEV++ Y+ KAD
Sbjct: 147 AANVLLS--EQG-DVKLADFGVAGQLTDTQI--KRNTFVGTPFWMAPEVIQQSAYDSKAD 201
Query: 239 VFSYGIILCEIIARIQADPDYLPRTENFGLDYDAFQHMVGDCPPDFLQLTFNCCNMDPKL 298
++S GI E+ + D P F + + +VGD F + C N DP
Sbjct: 202 IWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDACLNKDPSF 261
Query: 299 RPSFVEIGK 307
RP+ E+ K
Sbjct: 262 RPTAKELLK 270
>gi|66932918 MER receptor tyrosine kinase precursor [Homo sapiens]
Length = 999
Score = 110 bits (275), Expect = 3e-24
Identities = 100/371 (26%), Positives = 159/371 (42%), Gaps = 46/371 (12%)
Query: 83 VMALKMNTLSSNRAN-MLKEVQLMNRLSHPNILRFMGVCVHQGQLH-----ALTEYINSG 136
V +K++ S L E M SHPN++R +GVC+ + ++ G
Sbjct: 618 VKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYG 677
Query: 137 NLEQ-LLDSNL-----HLPWTVRVKLAYDIAVGLSYLHFKGIFHRDLTSKNCLIKRDENG 190
+L LL S L H+P +K DIA+G+ YL + HRDL ++NC+++ D
Sbjct: 678 DLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDD--- 734
Query: 191 YSAVVADFGLAEKIPDVSMGSEKLAVVGSPFWMAPEVLRDEPYNEKADVFSYGIILCEII 250
+ VADFGL++KI + W+A E L D Y K+DV+++G+ + EI
Sbjct: 735 MTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIA 794
Query: 251 ARIQADPDYLPRTENFGLDYDAFQH-----MVGDCPPDFLQLTFNCCNMDPKLRPSFVEI 305
R P +N + YD H DC + ++ ++C DP RP+F +
Sbjct: 795 TRGMTP---YPGVQNHEM-YDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVL 850
Query: 306 GKTLEEILSRLQEEEQERDRKLQPTARGLLEKAPGVKRLSSLDDKIPHKSPCPRRTIWLS 365
LE++L L + + D T LLE + G+ + S+L + P
Sbjct: 851 RLQLEKLLESLPDVRNQADVIYVNTQ--LLESSEGLAQGSTLAPLDLNIDP--------- 899
Query: 366 RSQSDIFSRKPPRTVSVLDPYYRPRDGAARTPKVNPFSARQDLMGGKIKFFDLPSKSVIS 425
S I S P +SV+ A P R L GG ++ DL S +
Sbjct: 900 --DSIIASCTPRAAISVV---------TAEVHDSKPHEGRYILNGGSEEWEDLTSAPSAA 948
Query: 426 LVFDLDAPGPG 436
+ + ++ PG
Sbjct: 949 VTAEKNSVLPG 959
>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
Length = 426
Score = 110 bits (275), Expect = 3e-24
Identities = 79/268 (29%), Positives = 133/268 (49%), Gaps = 10/268 (3%)
Query: 44 RALISAFSRLTRLDDFT-CEKIGSGFFSEVFKVRHRASGQVMALKMNTLSSNR---ANML 99
R + SR+ + FT ++IG G F EV+K + +V+A+K+ L ++
Sbjct: 5 RGFANQHSRVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQ 64
Query: 100 KEVQLMNRLSHPNILRFMGVCVHQGQLHALTEYINSGNLEQLLDSNLHLPWTVRVKLAYD 159
+E+ ++++ P I R+ G + +L + EY+ G+ LL L T + +
Sbjct: 65 QEITVLSQCDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLKPG-PLEETYIATILRE 123
Query: 160 IAVGLSYLHFKGIFHRDLTSKNCLIKRDENGYSAVVADFGLAEKIPDVSMGSEKLAVVGS 219
I GL YLH + HRD+ + N L+ E G +ADFG+A ++ D + ++ VG+
Sbjct: 124 ILKGLDYLHSERKIHRDIKAANVLLS--EQG-DVKLADFGVAGQLTDTQI--KRNTFVGT 178
Query: 220 PFWMAPEVLRDEPYNEKADVFSYGIILCEIIARIQADPDYLPRTENFGLDYDAFQHMVGD 279
PFWMAPEV++ Y+ KAD++S GI E+ + D P F + ++ + G
Sbjct: 179 PFWMAPEVIKQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQ 238
Query: 280 CPPDFLQLTFNCCNMDPKLRPSFVEIGK 307
F + C N DP+ RP+ E+ K
Sbjct: 239 HSKPFKEFVEACLNKDPRFRPTAKELLK 266
>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
Length = 491
Score = 110 bits (274), Expect = 5e-24
Identities = 62/189 (32%), Positives = 105/189 (55%), Gaps = 6/189 (3%)
Query: 62 EKIGSGFFSEVFKVRHRASGQVMALKMNTLSSNRANMLKEVQLMNRLSHPNILRFMGVCV 121
EK+G G + VFK H+ SGQV+A+K + S+ ++KE+ +M + P ++++ G
Sbjct: 31 EKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSPYVVKYYGSYF 90
Query: 122 HQGQLHALTEYINSGNLEQLLD-SNLHLPWTVRVKLAYDIAVGLSYLHFKGIFHRDLTSK 180
L + EY +G++ ++ N L + GL YLHF HRD+ +
Sbjct: 91 KNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAG 150
Query: 181 NCLIKRDENGYSAVVADFGLAEKIPDVSMGSEKLAVVGSPFWMAPEVLRDEPYNEKADVF 240
N L+ + + A +ADFG+A ++ D +++ V+G+PFWMAPEV+++ YN AD++
Sbjct: 151 NILLNTEGH---AKLADFGVAGQLTDTM--AKRNTVIGTPFWMAPEVIQEIGYNCVADIW 205
Query: 241 SYGIILCEI 249
S GI E+
Sbjct: 206 SLGITSIEM 214
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 110 bits (274), Expect = 5e-24
Identities = 59/189 (31%), Positives = 106/189 (56%), Gaps = 6/189 (3%)
Query: 62 EKIGSGFFSEVFKVRHRASGQVMALKMNTLSSNRANMLKEVQLMNRLSHPNILRFMGVCV 121
EK+G G + V+K H+ +GQ++A+K + S+ ++KE+ +M + P+++++ G
Sbjct: 34 EKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEIIKEISIMQQCDSPHVVKYYGSYF 93
Query: 122 HQGQLHALTEYINSGNLEQLLD-SNLHLPWTVRVKLAYDIAVGLSYLHFKGIFHRDLTSK 180
L + EY +G++ ++ N L + GL YLHF HRD+ +
Sbjct: 94 KNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAG 153
Query: 181 NCLIKRDENGYSAVVADFGLAEKIPDVSMGSEKLAVVGSPFWMAPEVLRDEPYNEKADVF 240
N L+ + + A +ADFG+A ++ D +++ V+G+PFWMAPEV+++ YN AD++
Sbjct: 154 NILLNTEGH---AKLADFGVAGQLTDTM--AKRNTVIGTPFWMAPEVIQEIGYNCVADIW 208
Query: 241 SYGIILCEI 249
S GI E+
Sbjct: 209 SLGITAIEM 217
>gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens]
Length = 451
Score = 108 bits (271), Expect = 1e-23
Identities = 92/272 (33%), Positives = 137/272 (50%), Gaps = 20/272 (7%)
Query: 57 DDFT-CEKIGSGFFSEVFKVRHRASGQVMALKMNTLSSNRANMLK-EVQLMNRLSHPNIL 114
++FT C K+GSG+F EVF+ + QV ++ + ML+ E+Q M +L H +IL
Sbjct: 189 EEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHIL 248
Query: 115 RFMGVCVHQGQLHALTEYINSGNLEQLL-DSNLH-LPWTVRVKLAYDIAVGLSYLHFKGI 172
V ++ +TE + G+L +LL DS+ LP + + +A+ +A G+ YL +
Sbjct: 249 ALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQNY 308
Query: 173 FHRDLTSKNCLIKRDENGYSAVVADFGLAEKIP-DVSMGSEKLAVVGSPF-WMAPEVLRD 230
HRDL ++N L+ + V DFGLA I DV + + P+ W APE L
Sbjct: 309 IHRDLAARNILVGENT---LCKVGDFGLARLIKEDVYLSHDH----NIPYKWTAPEALSR 361
Query: 231 EPYNEKADVFSYGIILCEIIARIQADPDYLPRTENFGLDYDAFQHMVG--DCPPDFLQLT 288
Y+ K+DV+S+GI+L E+ +R Q + E F L DA M +CPP +L
Sbjct: 362 GHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAF-LRVDAGYRMPCPLECPPSVHKLM 420
Query: 289 FNCCNMDPKLRPSFVEIGKTLEEILSRLQEEE 320
C DP+ RP F K L E LS E
Sbjct: 421 LTCWCRDPEQRPCF----KALRERLSSFTSYE 448
>gi|4758696 mitogen-activated protein kinase kinase kinase 13 [Homo
sapiens]
Length = 966
Score = 108 bits (271), Expect = 1e-23
Identities = 74/240 (30%), Positives = 121/240 (50%), Gaps = 14/240 (5%)
Query: 64 IGSGFFSEVFKVRHRASGQVMALKMNTLSSNRANMLKEVQLMNRLSHPNILRFMGVCVHQ 123
+GSG VF + RA + +A+K R +++ + +L HPNI+ F GVC
Sbjct: 174 LGSGAQGAVFLGKFRA--EEVAIK-----KVREQNETDIKHLRKLKHPNIIAFKGVCTQA 226
Query: 124 GQLHALTEYINSGNLEQLLDSNLHLPWTVRVKLAYDIAVGLSYLHFKGIFHRDLTSKNCL 183
+ EY G L ++L + + + V + IA G++YLH I HRDL S N L
Sbjct: 227 PCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVL 286
Query: 184 IKRDENGYSAVVADFGLAEKIPDVSMGSEKLAVVGSPFWMAPEVLRDEPYNEKADVFSYG 243
+ + + ++DFG ++++ D S K++ G+ WMAPEV+R+EP +EK D++S+G
Sbjct: 287 VTHTD---AVKISDFGTSKELSD---KSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFG 340
Query: 244 IILCEIIARIQADPDYLPRTENFGLDYDAFQHMV-GDCPPDFLQLTFNCCNMDPKLRPSF 302
++L E++ D +G+ ++ V CP F L P+ RPSF
Sbjct: 341 VVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSF 400
>gi|4758284 ephrin receptor EphB1 precursor [Homo sapiens]
Length = 984
Score = 107 bits (267), Expect = 3e-23
Identities = 78/265 (29%), Positives = 121/265 (45%), Gaps = 18/265 (6%)
Query: 62 EKIGSGFFSEVFKVRHRASGQ------VMALKMNTLSSNRANMLKEVQLMNRLSHPNILR 115
E IG+G F EV+K R + G+ + LK R + L E +M + HPNI+R
Sbjct: 623 EVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIR 682
Query: 116 FMGVCVHQGQLHALTEYINSGNLEQLLDSNLHLPWTVR-VKLAYDIAVGLSYLHFKGIFH 174
GV + +TE++ +G L+ L N ++ V + IA G+ YL H
Sbjct: 683 LEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLAEMNYVH 742
Query: 175 RDLTSKNCLIKRDENGYSAVVADFGLAEKIPDVSMGSEKLAVVGSPF---WMAPEVLRDE 231
RDL ++N L+ + V+DFGL+ + D + + +G W APE +
Sbjct: 743 RDLAARNILV---NSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAYR 799
Query: 232 PYNEKADVFSYGIILCEIIA---RIQADPDYLPRTENFGLDYDAFQHMVGDCPPDFLQLT 288
+ +DV+SYGI++ E+++ R D DY M DCP QL
Sbjct: 800 KFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPM--DCPAALHQLM 857
Query: 289 FNCCNMDPKLRPSFVEIGKTLEEIL 313
+C D RP F EI TL++++
Sbjct: 858 LDCWQKDRNSRPRFAEIVNTLDKMI 882
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 107 bits (266), Expect = 4e-23
Identities = 84/299 (28%), Positives = 141/299 (47%), Gaps = 21/299 (7%)
Query: 53 LTRLDDFTCEKIGSGFFSEVFK---VRHRASGQVMALKMNTLSSNRANMLKEVQLMNRLS 109
+ R D K+G G + EV++ ++ + V LK +T+ LKE +M +
Sbjct: 237 MERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEE--FLKEAAVMKEIK 294
Query: 110 HPNILRFMGVCVHQGQLHALTEYINSGNLEQLLD--SNLHLPWTVRVKLAYDIAVGLSYL 167
HPN+++ +GVC + + +TE++ GNL L + + V + +A I+ + YL
Sbjct: 295 HPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYL 354
Query: 168 HFKGIFHRDLTSKNCLIKRDENGYSAVVADFGLAEKIPDVSMGSEKLAVVGSPF---WMA 224
K HRDL ++NCL+ + + VADFGL+ + G A G+ F W A
Sbjct: 355 EKKNFIHRDLAARNCLVGEN---HLVKVADFGLSR----LMTGDTYTAHAGAKFPIKWTA 407
Query: 225 PEVLRDEPYNEKADVFSYGIILCEIIARIQADPDYLPRTENFG-LDYDAFQHMVGDCPPD 283
PE L ++ K+DV+++G++L EI + + ++ + L+ D CP
Sbjct: 408 PESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEK 467
Query: 284 FLQLTFNCCNMDPKLRPSFVEIGKTLEEIL---SRLQEEEQERDRKLQPTARGLLEKAP 339
+L C +P RPSF EI + E + S E E+E ++ A L +AP
Sbjct: 468 VYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKQGVRGAVSTLLQAP 526
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 107 bits (266), Expect = 4e-23
Identities = 84/299 (28%), Positives = 141/299 (47%), Gaps = 21/299 (7%)
Query: 53 LTRLDDFTCEKIGSGFFSEVFK---VRHRASGQVMALKMNTLSSNRANMLKEVQLMNRLS 109
+ R D K+G G + EV++ ++ + V LK +T+ LKE +M +
Sbjct: 256 MERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEE--FLKEAAVMKEIK 313
Query: 110 HPNILRFMGVCVHQGQLHALTEYINSGNLEQLLD--SNLHLPWTVRVKLAYDIAVGLSYL 167
HPN+++ +GVC + + +TE++ GNL L + + V + +A I+ + YL
Sbjct: 314 HPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYL 373
Query: 168 HFKGIFHRDLTSKNCLIKRDENGYSAVVADFGLAEKIPDVSMGSEKLAVVGSPF---WMA 224
K HRDL ++NCL+ + + VADFGL+ + G A G+ F W A
Sbjct: 374 EKKNFIHRDLAARNCLVGEN---HLVKVADFGLSR----LMTGDTYTAHAGAKFPIKWTA 426
Query: 225 PEVLRDEPYNEKADVFSYGIILCEIIARIQADPDYLPRTENFG-LDYDAFQHMVGDCPPD 283
PE L ++ K+DV+++G++L EI + + ++ + L+ D CP
Sbjct: 427 PESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEK 486
Query: 284 FLQLTFNCCNMDPKLRPSFVEIGKTLEEIL---SRLQEEEQERDRKLQPTARGLLEKAP 339
+L C +P RPSF EI + E + S E E+E ++ A L +AP
Sbjct: 487 VYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKQGVRGAVSTLLQAP 545
>gi|219842236 feline sarcoma oncogene isoform 4 [Homo sapiens]
Length = 694
Score = 106 bits (265), Expect = 5e-23
Identities = 84/268 (31%), Positives = 129/268 (48%), Gaps = 26/268 (9%)
Query: 62 EKIGSGFFSEVFKVRHRASGQVMALKM--NTLSSN-RANMLKEVQLMNRLSHPNILRFMG 118
E+IG G F EVF R RA ++A+K TL + +A L+E +++ + SHPNI+R +G
Sbjct: 437 EQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIVRLIG 496
Query: 119 VCVHQGQLHALTEYINSGN-LEQLLDSNLHLPWTVRVKLAYDIAVGLSYLHFKGIFHRDL 177
VC + ++ + E + G+ L L L +++ D A G+ YL K HRDL
Sbjct: 497 VCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDL 556
Query: 178 TSKNCLIKRDENGYSAVVADFGLAEKIPD----VSMGSEKLAVVGSPFWMAPEVLRDEPY 233
++NCL+ ++DFG++ + D S G ++ V W APE L Y
Sbjct: 557 AARNCLVTEKN---VLKISDFGMSREEADGVYAASGGLRQVPVK----WTAPEALNYGRY 609
Query: 234 NEKADVFSYGIILCEIIARIQADPDYLPRTENFGLDYDAFQHMVGD------CPPDFLQL 287
+ ++DV+S+GI+L E + + A P P N F G CP +L
Sbjct: 610 SSESDVWSFGILLWETFS-LGASP--YPNLSN--QQTREFVEKGGRLPCPELCPDAVFRL 664
Query: 288 TFNCCNMDPKLRPSFVEIGKTLEEILSR 315
C +P RPSF I + L+ I R
Sbjct: 665 MEQCWAYEPGQRPSFSTIYQELQSIRKR 692
>gi|219842233 feline sarcoma oncogene isoform 3 [Homo sapiens]
Length = 752
Score = 106 bits (265), Expect = 5e-23
Identities = 84/268 (31%), Positives = 129/268 (48%), Gaps = 26/268 (9%)
Query: 62 EKIGSGFFSEVFKVRHRASGQVMALKM--NTLSSN-RANMLKEVQLMNRLSHPNILRFMG 118
E+IG G F EVF R RA ++A+K TL + +A L+E +++ + SHPNI+R +G
Sbjct: 495 EQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIVRLIG 554
Query: 119 VCVHQGQLHALTEYINSGN-LEQLLDSNLHLPWTVRVKLAYDIAVGLSYLHFKGIFHRDL 177
VC + ++ + E + G+ L L L +++ D A G+ YL K HRDL
Sbjct: 555 VCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDL 614
Query: 178 TSKNCLIKRDENGYSAVVADFGLAEKIPD----VSMGSEKLAVVGSPFWMAPEVLRDEPY 233
++NCL+ ++DFG++ + D S G ++ V W APE L Y
Sbjct: 615 AARNCLVTEKN---VLKISDFGMSREEADGVYAASGGLRQVPVK----WTAPEALNYGRY 667
Query: 234 NEKADVFSYGIILCEIIARIQADPDYLPRTENFGLDYDAFQHMVGD------CPPDFLQL 287
+ ++DV+S+GI+L E + + A P P N F G CP +L
Sbjct: 668 SSESDVWSFGILLWETFS-LGASP--YPNLSN--QQTREFVEKGGRLPCPELCPDAVFRL 722
Query: 288 TFNCCNMDPKLRPSFVEIGKTLEEILSR 315
C +P RPSF I + L+ I R
Sbjct: 723 MEQCWAYEPGQRPSFSTIYQELQSIRKR 750
>gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens]
Length = 764
Score = 106 bits (265), Expect = 5e-23
Identities = 84/268 (31%), Positives = 129/268 (48%), Gaps = 26/268 (9%)
Query: 62 EKIGSGFFSEVFKVRHRASGQVMALKM--NTLSSN-RANMLKEVQLMNRLSHPNILRFMG 118
E+IG G F EVF R RA ++A+K TL + +A L+E +++ + SHPNI+R +G
Sbjct: 507 EQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIVRLIG 566
Query: 119 VCVHQGQLHALTEYINSGN-LEQLLDSNLHLPWTVRVKLAYDIAVGLSYLHFKGIFHRDL 177
VC + ++ + E + G+ L L L +++ D A G+ YL K HRDL
Sbjct: 567 VCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDL 626
Query: 178 TSKNCLIKRDENGYSAVVADFGLAEKIPD----VSMGSEKLAVVGSPFWMAPEVLRDEPY 233
++NCL+ ++DFG++ + D S G ++ V W APE L Y
Sbjct: 627 AARNCLVTEKN---VLKISDFGMSREEADGVYAASGGLRQVPVK----WTAPEALNYGRY 679
Query: 234 NEKADVFSYGIILCEIIARIQADPDYLPRTENFGLDYDAFQHMVGD------CPPDFLQL 287
+ ++DV+S+GI+L E + + A P P N F G CP +L
Sbjct: 680 SSESDVWSFGILLWETFS-LGASP--YPNLSN--QQTREFVEKGGRLPCPELCPDAVFRL 734
Query: 288 TFNCCNMDPKLRPSFVEIGKTLEEILSR 315
C +P RPSF I + L+ I R
Sbjct: 735 MEQCWAYEPGQRPSFSTIYQELQSIRKR 762
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.136 0.414
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,174,274
Number of Sequences: 37866
Number of extensions: 1314619
Number of successful extensions: 6237
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 578
Number of HSP's successfully gapped in prelim test: 231
Number of HSP's that attempted gapping in prelim test: 4033
Number of HSP's gapped (non-prelim): 1024
length of query: 571
length of database: 18,247,518
effective HSP length: 108
effective length of query: 463
effective length of database: 14,157,990
effective search space: 6555149370
effective search space used: 6555149370
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.