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Search of human proteins with 156104891
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|156104891 general transcription factor IIF, polypeptide 1,
74kDa [Homo sapiens]
(517 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|156104891 general transcription factor IIF, polypeptide 1, 74... 1030 0.0
gi|7661950 SH2 domain binding protein 1 [Homo sapiens] 73 5e-13
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 72 1e-12
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 70 6e-12
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ... 70 6e-12
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] 69 8e-12
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof... 69 8e-12
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof... 69 8e-12
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof... 69 8e-12
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof... 69 8e-12
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens] 69 1e-11
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens] 69 1e-11
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof... 68 2e-11
gi|48255931 hepatoma-derived growth factor-related protein 2 iso... 65 1e-10
gi|14249158 hepatoma-derived growth factor-related protein 2 iso... 65 1e-10
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens] 64 3e-10
gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens] 64 3e-10
gi|224589071 BMS1-like, ribosome assembly protein [Homo sapiens] 64 4e-10
gi|56118310 nuclear casein kinase and cyclin-dependent kinase su... 62 1e-09
gi|55956788 nucleolin [Homo sapiens] 62 2e-09
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 62 2e-09
gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens] 61 2e-09
gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1... 61 2e-09
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens] 61 3e-09
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 61 3e-09
gi|20270337 Leo1, Paf1/RNA polymerase II complex component, homo... 61 3e-09
gi|221219020 NYD-SP11 protein [Homo sapiens] 60 4e-09
gi|55741677 SET domain containing 1A [Homo sapiens] 60 5e-09
gi|21396500 HIRA interacting protein 3 [Homo sapiens] 60 5e-09
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa... 59 1e-08
>gi|156104891 general transcription factor IIF, polypeptide 1, 74kDa
[Homo sapiens]
Length = 517
Score = 1030 bits (2662), Expect = 0.0
Identities = 517/517 (100%), Positives = 517/517 (100%)
Query: 1 MAALGPSSQNVTEYVVRVPKNTTKKYNIMAFNAADKVNFATWNQARLERDLSNKKIYQEE 60
MAALGPSSQNVTEYVVRVPKNTTKKYNIMAFNAADKVNFATWNQARLERDLSNKKIYQEE
Sbjct: 1 MAALGPSSQNVTEYVVRVPKNTTKKYNIMAFNAADKVNFATWNQARLERDLSNKKIYQEE 60
Query: 61 EMPESGAGSEFNRKLREEARRKKYGIVLKEFRPEDQPWLLRVNGKSGRKFKGIKKGGVTE 120
EMPESGAGSEFNRKLREEARRKKYGIVLKEFRPEDQPWLLRVNGKSGRKFKGIKKGGVTE
Sbjct: 61 EMPESGAGSEFNRKLREEARRKKYGIVLKEFRPEDQPWLLRVNGKSGRKFKGIKKGGVTE 120
Query: 121 NTSYYIFTQCPDGAFEAFPVHNWYNFTPLARHRTLTAEEAEEEWERRNKVLNHFSIMQQR 180
NTSYYIFTQCPDGAFEAFPVHNWYNFTPLARHRTLTAEEAEEEWERRNKVLNHFSIMQQR
Sbjct: 121 NTSYYIFTQCPDGAFEAFPVHNWYNFTPLARHRTLTAEEAEEEWERRNKVLNHFSIMQQR 180
Query: 181 RLKDQDQDEDEEEKEKRGRRKASELRIHDLEDDLEMSSDASDASGEEGGRVPKAKKKAPL 240
RLKDQDQDEDEEEKEKRGRRKASELRIHDLEDDLEMSSDASDASGEEGGRVPKAKKKAPL
Sbjct: 181 RLKDQDQDEDEEEKEKRGRRKASELRIHDLEDDLEMSSDASDASGEEGGRVPKAKKKAPL 240
Query: 241 AKGGRKKKKKKGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEEPESKAKAPQQEEGPKG 300
AKGGRKKKKKKGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEEPESKAKAPQQEEGPKG
Sbjct: 241 AKGGRKKKKKKGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEEPESKAKAPQQEEGPKG 300
Query: 301 VDEQSDSSEESEEEKPPEEDKEEEEEKKAPTPQEKKRRKDSSEESDSSEESDIDSEASSA 360
VDEQSDSSEESEEEKPPEEDKEEEEEKKAPTPQEKKRRKDSSEESDSSEESDIDSEASSA
Sbjct: 301 VDEQSDSSEESEEEKPPEEDKEEEEEKKAPTPQEKKRRKDSSEESDSSEESDIDSEASSA 360
Query: 361 LFMAKKKTPPKRERKPSGGSSRGNSRPGTPSAEGGSTSSTLRAAASKLEQGKRVSEMPAA 420
LFMAKKKTPPKRERKPSGGSSRGNSRPGTPSAEGGSTSSTLRAAASKLEQGKRVSEMPAA
Sbjct: 361 LFMAKKKTPPKRERKPSGGSSRGNSRPGTPSAEGGSTSSTLRAAASKLEQGKRVSEMPAA 420
Query: 421 KRLRLDTGPQSLSGKSTPQPPSGKTTPNSGDVQVTEDAVRRYLTRKPMTTKDLLKKFQTK 480
KRLRLDTGPQSLSGKSTPQPPSGKTTPNSGDVQVTEDAVRRYLTRKPMTTKDLLKKFQTK
Sbjct: 421 KRLRLDTGPQSLSGKSTPQPPSGKTTPNSGDVQVTEDAVRRYLTRKPMTTKDLLKKFQTK 480
Query: 481 KTGLSSEQTVNVLAQILKRLNPERKMINDKMHFSLKE 517
KTGLSSEQTVNVLAQILKRLNPERKMINDKMHFSLKE
Sbjct: 481 KTGLSSEQTVNVLAQILKRLNPERKMINDKMHFSLKE 517
>gi|7661950 SH2 domain binding protein 1 [Homo sapiens]
Length = 1173
Score = 73.2 bits (178), Expect = 5e-13
Identities = 81/312 (25%), Positives = 121/312 (38%), Gaps = 33/312 (10%)
Query: 152 HRTLTAEEAEEEWERRNKVLNHFSIMQQRRLKDQDQDEDEEEKEKRGRRKASELRIHDLE 211
H ++ EEE E R K +++Q+ LK+Q E++ +EK ++K E R +E
Sbjct: 827 HVARARKQDEEERELRAKQEQEKELLRQKLLKEQ---EEKRLREKEEQKKLLEQRAQYVE 883
Query: 212 DDLEMSSDASDASGEEGGRVPKAKKKAPLAKGGRKKKKKKGSDDEAFEDSDDGDFEGQEV 271
+ + +A K+ GG ++ KK G DE D D D +
Sbjct: 884 KTKNILMFTGET---------EATKEKKRGGGGGRRSKKGGEFDEFVNDDTDDDLPISKK 934
Query: 272 DYMSDGSSSSQE---EPESKAKAPQQEEGPKGVDEQSDSSEESEEEKPPEEDKEEEEEKK 328
GS S QE E + K ++ PKG +E SD E KP + + E+KK
Sbjct: 935 KKRRKGSGSEQEGEDEEGGERKKKKRRRHPKG-EEGSDDDETENGPKPKKRRPPKAEKKK 993
Query: 329 APTPQEKKRRKDSSEESDSSEESDIDSEASSALFMAKKKTPPKRERKPSGGSSRGNSRPG 388
AP P+ +S + S DS L +A + P R + S R
Sbjct: 994 APKPERLPPSMKGKIKSKAIISSSDDSSDEDKLKIADEGHP--RNSNSNSDSDEDEQRKK 1051
Query: 389 TPSAEGGSTSSTLRAAASKLEQGKRVSEMPAAKRLRLDTGPQSLSGKSTPQPPSGKTTPN 448
S+E S + Q K SE + +R R Q S PS K P
Sbjct: 1052 CASSESDSDEN----------QNKSGSEAGSPRRPRRQRSDQD----SDSDQPSRKRRP- 1096
Query: 449 SGDVQVTEDAVR 460
SG Q ++V+
Sbjct: 1097 SGSEQSDNESVQ 1108
Score = 62.8 bits (151), Expect = 7e-10
Identities = 77/351 (21%), Positives = 131/351 (37%), Gaps = 54/351 (15%)
Query: 48 ERDLSNKKIYQEEEMPESGAGSEFNRKLREEARRKKYGIVLKEFRPEDQPWLLRVNGKSG 107
ER+L K+ ++E + + + ++LRE+ +KK ++ + + L+
Sbjct: 838 ERELRAKQEQEKELLRQKLLKEQEEKRLREKEEQKKLLEQRAQYVEKTKNILMFTGETEA 897
Query: 108 RKFKGIKKGGVTENTSYYIFTQCPDGAFEAFPVHNWYNFTPLARHRTLTAEEAEEEWERR 167
K K K+GG S G F+ F ++ +++
Sbjct: 898 TKEK--KRGGGGGRRSK------KGGEFDEF-----------------VNDDTDDD---- 928
Query: 168 NKVLNHFSIMQQRRLKDQDQDEDEEEKEKRGRRKASELRIHDLEDDLEMSSDASDASGEE 227
I ++++ + E E E E+ G RK + R H + SD E
Sbjct: 929 ------LPISKKKKRRKGSGSEQEGEDEEGGERKKKKRRRH------PKGEEGSDDDETE 976
Query: 228 GGRVPKAKKKAPLAKGGRKKKKKKGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEEPES 287
G PK KK+ P K +KKK E S G + + + SD SS E
Sbjct: 977 NG--PKPKKRRP-----PKAEKKKAPKPERLPPSMKGKIKSKAIISSSDDSSD-----ED 1024
Query: 288 KAKAPQQEEGPKGVDEQSDSSEESEEEKPPEEDKEEEEEKKAPTPQEKKRRKDSSEESDS 347
K K E P+ + SDS E+ + +K + + +E + + R+ + SD
Sbjct: 1025 KLKI-ADEGHPRNSNSNSDSDEDEQRKKCASSESDSDENQNKSGSEAGSPRRPRRQRSDQ 1083
Query: 348 SEESDIDSEASSALFMAKKKTPPKRERKPSGGSSRGNSRPGTPSAEGGSTS 398
+SD S + + + G S +SRP +PSAE S
Sbjct: 1084 DSDSDQPSRKRRPSGSEQSDNESVQSGRSHSGVSENDSRPASPSAESDHES 1134
Score = 53.5 bits (127), Expect = 4e-07
Identities = 55/251 (21%), Positives = 101/251 (40%), Gaps = 36/251 (14%)
Query: 176 IMQQRRLKDQDQDEDEEEKEKRGRRKASELRIHDLEDDLEMSSDASDASGEEGGRVPKA- 234
I ++++ + E E E E+ G RK + R H ++ + + + R PKA
Sbjct: 931 ISKKKKRRKGSGSEQEGEDEEGGERKKKKRRRHPKGEEGSDDDETENGPKPKKRRPPKAE 990
Query: 235 KKKAP----LAKGGRKKKKKKGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEEPESKAK 290
KKKAP L + K K K + + SD+ + + + + +S+S + + + K
Sbjct: 991 KKKAPKPERLPPSMKGKIKSKAIISSSDDSSDEDKLKIADEGHPRNSNSNSDSDEDEQRK 1050
Query: 291 APQQEEGPKGVDEQSDSSEESEEEKPPEEDKEEEEEKKAPTPQEKKRRKDSSEESDS--- 347
E ++ SE +P + +++ + P+ +KRR SE+SD+
Sbjct: 1051 KCASSESDSDENQNKSGSEAGSPRRPRRQRSDQDSDSDQPS---RKRRPSGSEQSDNESV 1107
Query: 348 -------------------SEESDIDSEASSALFMAKKKTPPKRERKPSGGSSRGNSRPG 388
S ESD +SE S + + + E +P G ++ + R
Sbjct: 1108 QSGRSHSGVSENDSRPASPSAESDHESERGSDNEGSGQGS--GNESEPEGSNNEASDR-- 1163
Query: 389 TPSAEGGSTSS 399
+E GS S
Sbjct: 1164 --GSEHGSDDS 1172
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 72.0 bits (175), Expect = 1e-12
Identities = 54/242 (22%), Positives = 107/242 (44%), Gaps = 16/242 (6%)
Query: 161 EEEWERRNKVLNHFSIMQQRRLKDQDQDEDEEEKEKRGRRKASELRIHDLEDDLEMSSDA 220
+EEW++R+ +Q K+++Q+ +E +E+ G + E D E++ E
Sbjct: 699 KEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEE---GDREEEEE----- 750
Query: 221 SDASGEEGGRVPKAKKKAPLAKGGRKKKKKKGSDDEAFEDSDDGDFEGQEVDYMSD---- 276
+ G+E G + + + +G RKK+++ G +++ E+ D G+ E +E + +
Sbjct: 751 KEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEE 810
Query: 277 -GSSSSQEEPESKAKAPQQEEGPKGVDEQSDSSE---ESEEEKPPEEDKEEEEEKKAPTP 332
G E E K + ++EE +G +E+ + E E EEE+ + +EE EE +
Sbjct: 811 GGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEE 870
Query: 333 QEKKRRKDSSEESDSSEESDIDSEASSALFMAKKKTPPKRERKPSGGSSRGNSRPGTPSA 392
E+ + EE + E + + E + + + E + G +G
Sbjct: 871 GEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEG 930
Query: 393 EG 394
EG
Sbjct: 931 EG 932
Score = 64.7 bits (156), Expect = 2e-10
Identities = 59/270 (21%), Positives = 112/270 (41%), Gaps = 15/270 (5%)
Query: 158 EEAEEEWERRNKVLNHFSIMQQRRLKDQDQDEDEEEKEKRGRRKASELRIHDLEDDLEMS 217
E EEE E R + ++ +++ + +EEE+E G + E E++ E
Sbjct: 795 EGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGE----GEEEEGEGE 850
Query: 218 SDASDASGEEGGRVPKAKKKAPLAKGGRKKKKKKGSDDEAFE---DSDDGDFEGQE---- 270
+ + GEE G + +++ +G ++++ +G +E E + ++G+ EG+E
Sbjct: 851 EEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEG 910
Query: 271 VDYMSDGSSSSQEEPESKAKAPQQEEGP-KGVDEQSDSSEESEEEKPPEEDKEEEEEKKA 329
+G +EE E ++EEG +G D + + EE E + EE+ E E E++
Sbjct: 911 EGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEG 970
Query: 330 PTPQEKKRRKDSSEESDSSEESDIDSEASSALFMAKKKTPPKRERKPSG---GSSRGNSR 386
E+ + EE + E + E +++ + E + G G G
Sbjct: 971 EGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEG 1030
Query: 387 PGTPSAEGGSTSSTLRAAASKLEQGKRVSE 416
G E G R + E+ +R E
Sbjct: 1031 EGEGEEEEGEEEGEEREKEGEGEENRRNRE 1060
Score = 64.3 bits (155), Expect = 3e-10
Identities = 51/237 (21%), Positives = 105/237 (44%), Gaps = 9/237 (3%)
Query: 158 EEAEEEWERRNKVLNHFSIMQQRRLKDQDQDEDEEEKEKRGRRKASELRIHDLEDDLEMS 217
EE E E E + + ++ + + +EEE E +G + E E++ E
Sbjct: 881 EEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGE 940
Query: 218 SDASDASGEEGGRVPKAKKKAPLAKGGRKKKKKKGSDDEAFEDSDDGDFEGQEVDYMSDG 277
+ + GEE + +++ +G ++ + +G + E + ++G+ EG+E + +G
Sbjct: 941 GEDGEGEGEEEEGEWEGEEEEGEGEG-EEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEG 999
Query: 278 SSSSQEEPESKAKAPQQEEGP-----KGVDEQSDSSEESEEEKPPEEDKEEEEEKKAPTP 332
+ E E + + ++EEG +G + + + EE EE+ E +KE E E+
Sbjct: 1000 EEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNR 1059
Query: 333 QEKKRRKDSSEESDSSEESDIDSEASSALFMAK---KKTPPKRERKPSGGSSRGNSR 386
+E++ + +E+ E D E + K K K +K S +++GN +
Sbjct: 1060 EEEEEEEGKYQETGEEENERQDGEEYKKVSKIKGSVKYGKHKTYQKKSVTNTQGNGK 1116
Score = 58.9 bits (141), Expect = 1e-08
Identities = 50/199 (25%), Positives = 89/199 (44%), Gaps = 16/199 (8%)
Query: 159 EAEEEWERRNKVLNHFSIMQQRRLKDQDQDEDEEEKEKRGRRKASELRIHDLEDDLEMSS 218
E EEE E K ++ R +++E E +KE+R ++ D + E +
Sbjct: 746 EEEEEKEGEGKEEGEGEEVEGER----EKEEGERKKEERAGKEEKGEEEGDQGEGEEEET 801
Query: 219 DASDASGEEGGRVPKAKKKAPLAKGGRKKKKKKGSDDEAFEDSDDGDFEGQEVDYMSDGS 278
+ EEGG V + + KG R++++++G +E + ++ + EG+E +G
Sbjct: 802 EGRGEEKEEGGEVEGGEVEE--GKGEREEEEEEGEGEEEEGEGEEEEGEGEE----EEGE 855
Query: 279 SSSQEEPESKAKAPQQEEGPKGVDEQSDSSEESEEEKPPEEDKEE-----EEEKKAPTPQ 333
+EE E + EEG +G E+ + E EEE E ++EE EEE + +
Sbjct: 856 GKGEEEGEEGEGEEEGEEG-EGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEE 914
Query: 334 EKKRRKDSSEESDSSEESD 352
E+ K E + E +
Sbjct: 915 EEGEGKGEEEGEEGEGEGE 933
Score = 58.9 bits (141), Expect = 1e-08
Identities = 50/202 (24%), Positives = 93/202 (46%), Gaps = 12/202 (5%)
Query: 159 EAEEEWERRNKVLNHFSIMQQRRLKDQDQDE-DEEEKEKRGRRK--ASELRIHDLEDDL- 214
E E E E + + +++ ++ DQ E +EEE E RG K E+ ++E+
Sbjct: 765 EGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKG 824
Query: 215 EMSSDASDASGEEGGRVPKAKKKAPLAKGGRKKKKKKGSDDEAFEDSDDGDFEGQEVDYM 274
E + + GEE + ++ + G K +++G + E E+ ++G+ EG+E
Sbjct: 825 EREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEE---- 880
Query: 275 SDGSSSSQEEPESKAKAPQQEEGPKGVDEQSDSSEESEEEKPPEEDKEEEEEKKAPTPQE 334
+G +EE E + ++EEG +G E+ E EEE + ++E EE + +E
Sbjct: 881 EEGEGEGEEEGEGEG---EEEEG-EGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEE 936
Query: 335 KKRRKDSSEESDSSEESDIDSE 356
+ + E EE + + E
Sbjct: 937 GEGEGEDGEGEGEEEEGEWEGE 958
Score = 57.8 bits (138), Expect = 2e-08
Identities = 67/327 (20%), Positives = 126/327 (38%), Gaps = 31/327 (9%)
Query: 158 EEAEEEWERRNKVLNHFSIMQQRRLKDQDQDEDEEEKEKRGRRKASELRIHDLEDDLEMS 217
EE EEE E ++ ++++ + +EEE E +G + E + ++ E
Sbjct: 827 EEEEEEGEGEE---------EEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGE 877
Query: 218 SDASDASGE---EG-GRVPKAKKKAPLAKGGRKKKKKKGSDDEAFEDSDDGDFEGQEVDY 273
+ + GE EG G + + + + G + +++ + + E+ ++G+ EG+E +
Sbjct: 878 GEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEG 937
Query: 274 MSDGSSSSQEEPESKAKAPQQEEGPKGVDEQSDSSE----ESEEEKPPEEDKEEEEEKKA 329
+G E E + + +EE +G E+ E E E E+ E + EEEE +
Sbjct: 938 EGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEE 997
Query: 330 PTPQEKKRRKDSSEESDSSEESDIDSEASSALFMAKKKTPPKRERKPSGGSSRGNSRPGT 389
+E + ++ E + EE +++ E E + G G
Sbjct: 998 EGEEEGEGEEEGEGEGEEEEEGEVEGEVEG------------EEGEGEGEEEEGEEEGEE 1045
Query: 390 PSAEGGSTSSTLRAAASKLEQGKRVSEMPAAKRLRLDTGPQSLSGKSTPQPPSGK-TTPN 448
EG + + E+GK E + R D K GK T
Sbjct: 1046 REKEGEGEENRRNREEEEEEEGK-YQETGEEENERQDGEEYKKVSKIKGSVKYGKHKTYQ 1104
Query: 449 SGDVQVTEDAVRRYLTRKPMTTKDLLK 475
V T+ + ++ P+ +K LLK
Sbjct: 1105 KKSVTNTQGNGKEQRSKMPVQSKRLLK 1131
Score = 50.1 bits (118), Expect = 5e-06
Identities = 47/232 (20%), Positives = 96/232 (41%), Gaps = 46/232 (19%)
Query: 182 LKDQDQDEDEEE-KEKRGRRKASELRIHDLEDDLEMSSDASDASGE-------------- 226
+++Q+ + +EE K GR++ +E+ DL D E+S + + GE
Sbjct: 601 IEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKAKSVGEAEDGPEGRGDGTCE 660
Query: 227 ------------EGGRVPKAKKKAPLAKGGRKKKKKKGSDDEAFEDSDDGDFEGQEVDYM 274
E + K K + + + G +K+ ++ D ++ + + +E +
Sbjct: 661 EGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQ 720
Query: 275 SDGSSSSQEEPESKAKAPQQEEGPKGVDEQSDSSEESE---EEKPPEEDKEEEEEKKAPT 331
+ + +E E + ++EEG + +E+ + + E EE E +KEE E KK
Sbjct: 721 KERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKK--- 777
Query: 332 PQEKKRRKDSSEESDSSEESDIDSEASSALFMAKKKTPPKRERKPSGGSSRG 383
+E+ +++ EE E + +++T + E K GG G
Sbjct: 778 -EERAGKEEKGEEEGDQGEGE------------EEETEGRGEEKEEGGEVEG 816
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 69.7 bits (169), Expect = 6e-12
Identities = 76/359 (21%), Positives = 146/359 (40%), Gaps = 28/359 (7%)
Query: 148 PLARHR---TLTAEEAEEEWERRNKVLNHFSIMQQRRLKDQDQDEDEEEKEKRGRRKASE 204
PL HR T++++ + + E + H + + +++ ++++ E E+ E
Sbjct: 422 PLYTHRPPITISSKIQKPKVEAPKLKVQHKFV--EEIIEETKVEDEKSEMEEALTAITEE 479
Query: 205 LRIHDLEDDLEMSSDASDASGEEGGRVPKAKKKAPLAKGGRKKKKKKGS-DDEAFEDSDD 263
L + E+ E + + + E V A KK+P+ + K+++G ++E ++ ++
Sbjct: 480 LAVSMKEEKKEAAEEKEEEPEAEEEEV--AAKKSPVKATAPEVKEEEGEKEEEEGQEEEE 537
Query: 264 GDFEGQEVDYMSDGSSSSQEEPESKAKAPQQEEGPKGVDEQSDSSEESEEEKPPEEDKE- 322
+ EG + D +G S ++E S+ + +QEEG + + + +E EE+K E+ +E
Sbjct: 538 EEDEGAKSDQAEEGGS--EKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEV 595
Query: 323 -------------EEEEKKAPTPQEKKRRKDSSEESDSSEESDIDSEASSALFMAKKKTP 369
+ E+ K+P P+ K S S E S + K K+P
Sbjct: 596 ATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSP 655
Query: 370 PKRERKPSGGSSRGNSRPGTPSAEGGSTSSTLRAAASKLEQGKRVSEMPAAKRLRLDTGP 429
+ G S + P A+ S + A SK E GK E + + P
Sbjct: 656 VPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGK--GEQKEEEEKEVKEAP 713
Query: 430 QSLSGKSTPQPPSGKTTPNSGDVQVTEDAVRRYLTRKPMTTKDLLKKFQTKKTGLSSEQ 488
+ + + P + V E+AV +T L K +TK+ G +Q
Sbjct: 714 KEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEK--ETKEEGKPLQQ 770
Score = 33.5 bits (75), Expect = 0.48
Identities = 38/168 (22%), Positives = 62/168 (36%), Gaps = 12/168 (7%)
Query: 215 EMSSDASDASGEEGGRVPKAKKKAPLAKGGRKKKKKKGS--DDEAFEDSDDGDFEGQEVD 272
E S A GE+ K K+AP + KK++K + + E + + V
Sbjct: 689 EAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVT 748
Query: 273 YMSDGSSSSQEEPESKAKAPQQEEGPKGVDEQSDSSEESEEEKPPEEDKEE-----EEEK 327
++E + + K QQE+ + + S EE ++ KE+ E E
Sbjct: 749 ITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEG 808
Query: 328 KAPTPQEKKRRKDSSEESDSSEESDIDSEASSALFMAKKKTPPKRERK 375
K QE K + EE + +D + +KK K E K
Sbjct: 809 KEEVEQETKEKGSGREEEKGVVTNGLDLSPAD-----EKKGGDKSEEK 851
Score = 32.7 bits (73), Expect = 0.82
Identities = 38/168 (22%), Positives = 70/168 (41%), Gaps = 21/168 (12%)
Query: 183 KDQDQDEDEEEKEKRGRRKASELRIHDLEDDLEMSSDASDASGEEGGRVPKAKKKAPLAK 242
K + ++E+E+E ++ + + E + +D E S E V K +
Sbjct: 698 KGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHL 757
Query: 243 GGRKKKKKKGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEEPESKAKAPQQEEGPKGVD 302
K+ K++G + ++ + EG S +E + AK ++E+ V+
Sbjct: 758 --EKETKEEGKPLQQEKEKEKAGGEG----------GSEEEGSDKGAKGSRKED--IAVN 803
Query: 303 EQSDSSEESEEEKPPEEDKEEEEEKKAPT------PQEKKRRKDSSEE 344
+ + EE E+E E+ EEEK T P ++K+ D SEE
Sbjct: 804 GEVEGKEEVEQE-TKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEE 850
>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
[Homo sapiens]
Length = 540
Score = 69.7 bits (169), Expect = 6e-12
Identities = 76/359 (21%), Positives = 146/359 (40%), Gaps = 28/359 (7%)
Query: 148 PLARHR---TLTAEEAEEEWERRNKVLNHFSIMQQRRLKDQDQDEDEEEKEKRGRRKASE 204
PL HR T++++ + + E + H + + +++ ++++ E E+ E
Sbjct: 46 PLYTHRPPITISSKIQKPKVEAPKLKVQHKFV--EEIIEETKVEDEKSEMEEALTAITEE 103
Query: 205 LRIHDLEDDLEMSSDASDASGEEGGRVPKAKKKAPLAKGGRKKKKKKGS-DDEAFEDSDD 263
L + E+ E + + + E V A KK+P+ + K+++G ++E ++ ++
Sbjct: 104 LAVSMKEEKKEAAEEKEEEPEAEEEEV--AAKKSPVKATAPEVKEEEGEKEEEEGQEEEE 161
Query: 264 GDFEGQEVDYMSDGSSSSQEEPESKAKAPQQEEGPKGVDEQSDSSEESEEEKPPEEDKE- 322
+ EG + D +G S ++E S+ + +QEEG + + + +E EE+K E+ +E
Sbjct: 162 EEDEGAKSDQAEEGGS--EKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEV 219
Query: 323 -------------EEEEKKAPTPQEKKRRKDSSEESDSSEESDIDSEASSALFMAKKKTP 369
+ E+ K+P P+ K S S E S + K K+P
Sbjct: 220 ATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSP 279
Query: 370 PKRERKPSGGSSRGNSRPGTPSAEGGSTSSTLRAAASKLEQGKRVSEMPAAKRLRLDTGP 429
+ G S + P A+ S + A SK E GK E + + P
Sbjct: 280 VPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGK--GEQKEEEEKEVKEAP 337
Query: 430 QSLSGKSTPQPPSGKTTPNSGDVQVTEDAVRRYLTRKPMTTKDLLKKFQTKKTGLSSEQ 488
+ + + P + V E+AV +T L K +TK+ G +Q
Sbjct: 338 KEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEK--ETKEEGKPLQQ 394
Score = 33.5 bits (75), Expect = 0.48
Identities = 38/168 (22%), Positives = 62/168 (36%), Gaps = 12/168 (7%)
Query: 215 EMSSDASDASGEEGGRVPKAKKKAPLAKGGRKKKKKKGS--DDEAFEDSDDGDFEGQEVD 272
E S A GE+ K K+AP + KK++K + + E + + V
Sbjct: 313 EAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVT 372
Query: 273 YMSDGSSSSQEEPESKAKAPQQEEGPKGVDEQSDSSEESEEEKPPEEDKEE-----EEEK 327
++E + + K QQE+ + + S EE ++ KE+ E E
Sbjct: 373 ITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEG 432
Query: 328 KAPTPQEKKRRKDSSEESDSSEESDIDSEASSALFMAKKKTPPKRERK 375
K QE K + EE + +D + +KK K E K
Sbjct: 433 KEEVEQETKEKGSGREEEKGVVTNGLDLSPAD-----EKKGGDKSEEK 475
Score = 32.7 bits (73), Expect = 0.82
Identities = 38/168 (22%), Positives = 70/168 (41%), Gaps = 21/168 (12%)
Query: 183 KDQDQDEDEEEKEKRGRRKASELRIHDLEDDLEMSSDASDASGEEGGRVPKAKKKAPLAK 242
K + ++E+E+E ++ + + E + +D E S E V K +
Sbjct: 322 KGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHL 381
Query: 243 GGRKKKKKKGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEEPESKAKAPQQEEGPKGVD 302
K+ K++G + ++ + EG S +E + AK ++E+ V+
Sbjct: 382 --EKETKEEGKPLQQEKEKEKAGGEG----------GSEEEGSDKGAKGSRKED--IAVN 427
Query: 303 EQSDSSEESEEEKPPEEDKEEEEEKKAPT------PQEKKRRKDSSEE 344
+ + EE E+E E+ EEEK T P ++K+ D SEE
Sbjct: 428 GEVEGKEEVEQE-TKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEE 474
>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
Length = 2400
Score = 69.3 bits (168), Expect = 8e-12
Identities = 69/288 (23%), Positives = 118/288 (40%), Gaps = 25/288 (8%)
Query: 178 QQRRLKDQDQDEDEEEKEKRGR-RKASELRIHDLEDDLEMSSDASDASGEEGGRVPKAKK 236
Q+ + Q + E E E G +KA + + E + + S+ +A EG P+++
Sbjct: 2088 QEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEG 2147
Query: 237 KAPLAKGGRKKKKKKGSDDEAFEDSDDGDFEG---QEVDYMSDGSSSSQEEPESKAKAPQ 293
G + + +G + + E+ + EG E + + S E PE++ +A
Sbjct: 2148 VEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQP 2207
Query: 294 QEEGPKGVDEQSDSSEESEEEKPPEEDKEEEEEKKAPTPQEKKRRKDSSEESDSSEESDI 353
+ EG + + + ++ E E + PE + E + E + T EKK S SEE+
Sbjct: 2208 ELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPESEGETQGEKKGSPQVSLGDGQSEEA-- 2265
Query: 354 DSEASSALFMAKKKTPPKRERKPSGGSSRGNSRPGTPSAEGGSTSSTLRAAASKLEQGKR 413
SE+SS + + TPP PS G + RPG+ + S +S+ K +
Sbjct: 2266 -SESSSPV-PEDRPTPP-----PSPGGDTPHQRPGSQTGPSSSRASSWGNCWQKDSENDH 2318
Query: 414 V-----------SEMPAAKRLRLDTGPQSLSGKSTPQPPSGKTTPNSG 450
V + P A+R P+S S + P G TP G
Sbjct: 2319 VLGDTRSPDAKSTGTPHAERKATRMYPES-STSEQEEAPLGSRTPEQG 2365
Score = 57.0 bits (136), Expect = 4e-08
Identities = 54/277 (19%), Positives = 109/277 (39%), Gaps = 15/277 (5%)
Query: 189 EDEEEKEKRGRRKASELRIHDLEDDLEMSS------DASDASGEEGGRVPKAKKKAPLAK 242
E E+E E R + + ED+L+ + D + G EG P+A+ +A
Sbjct: 1789 EAEQEGEGISERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPES 1848
Query: 243 GGRKKKKKKGSDDEAFEDS--DDGDFEGQEVDYMSDGSSSSQEEPESKAKAPQQEEGPKG 300
G + + +G EA ++ + D E E + + S E PE++ + + EG +
Sbjct: 1849 EGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEA 1908
Query: 301 VDEQSDSSEESEEEKPPEEDKEEEEEKKAPTPQEKKRRKDSSEESDSSEESDIDSEASSA 360
+ + ++ E+E + E + E+E E + QE + +E E I+S+ +
Sbjct: 1909 PEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEE 1968
Query: 361 LFMAKKKTPPKRERKPSGGSSRGNSRPGTPSAEGGSTSSTLRAAASKLE-QGKRVSEMPA 419
+ + E + + G ++P + E ++ A + + + V P
Sbjct: 1969 EAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPK 2028
Query: 420 AKRLRLDTGPQSLSGKSTPQPPSGKTTPNSGDVQVTE 456
++ G ++ + Q G P S V+ E
Sbjct: 2029 SE------GEEAQEVEGETQKTEGDAQPESDGVEAPE 2059
Score = 53.1 bits (126), Expect = 6e-07
Identities = 61/328 (18%), Positives = 129/328 (39%), Gaps = 44/328 (13%)
Query: 155 LTAEEAEEEWERRNKVLNHFSI---MQQRRLKDQDQDEDEEEKEKRGRRKASELRIHDLE 211
+ ++EAEEE + ++ + + Q+ + Q + ED E E G + + E
Sbjct: 1961 IESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGE-------MQEAE 2013
Query: 212 DDLEMSSDASDASGE-EGGRVPKAKKKAPLAKGGRKKKKKKGSDDEAFEDSDDGDFEGQE 270
++ + SD +A + EG + + + +G + + EA E++ + + E QE
Sbjct: 2014 EEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQE 2073
Query: 271 VDYMSDGSSSSQEEPESKAKAPQQEEGPKGVDEQSDSSEESEEEKPPEEDKEEEEEKKAP 330
+ + S + E++ +A + EG + + + ++ + E P E + + E +
Sbjct: 2074 AEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIE 2133
Query: 331 TPQ---EKKRRKDSSEESDSSEESDIDSEASSALFMAKKKTPPKRERKPSGGSSRGNSRP 387
P+ E + + E D+ E+ +SE A A+++ P+ E + G ++P
Sbjct: 2134 APEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQ-EAEEEAQPELE-GVEAPEAEGEAQP 2191
Query: 388 GT-----PSAEG-----------------------GSTSSTLRAAASKLEQGKRVSEMPA 419
+ P AEG G + A +G+ E
Sbjct: 2192 ESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPESEGETQGEKKG 2251
Query: 420 AKRLRLDTGPQSLSGKSTPQPPSGKTTP 447
+ ++ L G + +S+ P + TP
Sbjct: 2252 SPQVSLGDGQSEEASESSSPVPEDRPTP 2279
Score = 48.5 bits (114), Expect = 1e-05
Identities = 59/280 (21%), Positives = 112/280 (40%), Gaps = 18/280 (6%)
Query: 185 QDQDEDEEEKEKRGRRKASELRIHDLEDDLEMSSDASDASGE-EGGRVPKAKKKA-PLAK 242
Q + E E E G + +E +D+E +A E E P+A+ + P ++
Sbjct: 1845 QPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESE 1904
Query: 243 GGRKKKKKKGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEEPESKAKAPQQEEGPKGVD 302
G + +K + E E + + EG++ + S+G+ + + E +A Q+ EG +
Sbjct: 1905 GAEAPEAEKEAQPET-ESVEALETEGED-EPESEGAEAQEAE-----EAAQEAEGQTQPE 1957
Query: 303 EQSDSSEESEEEKPPEEDKEEEEEKKAPTPQEKKRRKDSSEESDSSEESDIDSEASSALF 362
+ S+E+EEE PE + E E + T + + ++ ES+ E + + E A
Sbjct: 1958 SEVIESQEAEEEAQPESEDVEALEVEVETQEAEG---EAQPESEDVEAPEAEGEMQEAEE 2014
Query: 363 MAKKKTPPKRERKPSGGSSRGNSRPGTPSAEGGSTSSTLRAAASKLEQGKRVSEMPA--- 419
A+ ++ + S G T EG + + A + E+ + +E
Sbjct: 2015 EAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEA 2074
Query: 420 ---AKRLRLDTGPQSLSGKSTPQPPSGKTTPNSGDVQVTE 456
A D Q G++ P+ + G+ Q E
Sbjct: 2075 EGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAE 2114
Score = 42.7 bits (99), Expect = 8e-04
Identities = 57/254 (22%), Positives = 101/254 (39%), Gaps = 44/254 (17%)
Query: 188 DEDEEEKEKRGRRKASELR-----IHDLEDDLEMSSDASDASG--EEGGRVPKAKKKAPL 240
+EDE E++ +R +S L E LE + + ++ G EE ++ + K + L
Sbjct: 1272 NEDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGL 1331
Query: 241 AKGGRKKKKKKGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEE----------PESKAK 290
+ G + ++ K ++ E ++ E Q + G QEE PE +
Sbjct: 1332 QEEGVQLEETKETEGEGQQEE-----EAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQ 1386
Query: 291 APQQEEGPK--GVDEQSD--SSEESEEEKPPEEDKEEEEEKKAPTPQEKKRRKDSSEESD 346
EEG K G+ E+ E SE P + +E++ P +E+ R +S E
Sbjct: 1387 GEALEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDD----PVQEEEAGRASASAEPC 1442
Query: 347 SSEESDIDSEASSALFMAKKKTPPKRER-----------KPSGGSSRGNSRPGTPSAEGG 395
+E ++ +E S L + P ER KP G + G +G
Sbjct: 1443 PAEGTEEPTEPPSHL---SETDPSASERQSGSQLEPGLEKPPGATMMGQEHTQAQPTQGA 1499
Query: 396 STSSTLRAAASKLE 409
+ S+ A ++ L+
Sbjct: 1500 AERSSSVACSAALD 1513
Score = 33.1 bits (74), Expect = 0.63
Identities = 26/94 (27%), Positives = 41/94 (43%), Gaps = 10/94 (10%)
Query: 374 RKPSGGSSRGNSRPGTPSAEGGSTSSTLRAAASKLEQGKRVSEMPAAKRLRLDTGPQSLS 433
R P G G +PG + G ++ ++ R++AS+ + +SE K LR GPQ
Sbjct: 882 RGPGGSPQEGTRQPGPTPSPGPNSGASRRSSASQGAGSRGLSE---EKTLRSGGGPQG-- 936
Query: 434 GKSTPQPPSGKTTPNSGDVQVTEDAVRRYLTRKP 467
Q + +P+S E VR +L P
Sbjct: 937 -----QEEASGVSPSSLPRSSPEAVVREWLDNIP 965
>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
9 [Homo sapiens]
Length = 771
Score = 69.3 bits (168), Expect = 8e-12
Identities = 79/294 (26%), Positives = 121/294 (41%), Gaps = 43/294 (14%)
Query: 151 RHRTLTAEEAEEEWER--RNKVLNHFSIMQQRRLKD--------------QDQDEDEEEK 194
RHR ++A EWER R ++ S ++ RL+ Q + +++E+
Sbjct: 125 RHRE-EQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKER 183
Query: 195 EKRG--RRKASELRIHDLEDDLEMSSDASD-ASGEEGGRVPKAKKKAPLAKGGRKKKKKK 251
E+R RRK E R M D SD R P + G +K K+
Sbjct: 184 ERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKE 243
Query: 252 GSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEEPESKAKAPQQEEGPKGVDEQSDSSEES 311
+E SD D E S SSS+ ES + + ++EE + +E+ +SEES
Sbjct: 244 EKMEERDLLSDLQDISDSERKTSSAESSSA----ESGSGSEEEEEEEEEEEEEGSTSEES 299
Query: 312 EEEKPPEEDKEEEEEKKAPTPQEKKRRKDSSEESDSSEESDIDSEASSALFMAKKKTPPK 371
EEE E++EEEEE++ + E+ + + E S+ D + E + L + P
Sbjct: 300 EEE----EEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLV----VPES 351
Query: 372 RERKPSGGSSRGNSRPGTPSAEGGSTSSTLRAAASKLEQGKRVSEMPAAKRLRL 425
R + SG S G EG SS L +G V + PA + L
Sbjct: 352 RFDRDSGESEEAEEEVG----EGTPQSSA-------LTEGDYVPDSPALSPIEL 394
Score = 32.3 bits (72), Expect = 1.1
Identities = 44/216 (20%), Positives = 78/216 (36%), Gaps = 32/216 (14%)
Query: 245 RKKKKKKGSDDEAFEDSDDGDF------EGQEVDYM------------SDGSSSSQEEPE 286
R+K++++ ++ + ++SDD D EG+ D+ D EE +
Sbjct: 22 RRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDRGEEDD 81
Query: 287 SKAKAPQQEEGPKGVDEQSDSSEESEEEKPPEEDKEEEEEK---------KAPTPQEKKR 337
S A P Q+ K + E++ ++KE E E+ KA E+++
Sbjct: 82 SLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQK 141
Query: 338 RKDSSEESDSSEESDIDSEASSALFMAKKKTPPKRERKPSGGSSRGNSRPGTPSA--EGG 395
R++ + E E ++ K + K +R+ R R A E
Sbjct: 142 RREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVS 201
Query: 396 STSSTLRAAAS---KLEQGKRVSEMPAAKRLRLDTG 428
+ T+R S K R P +R L G
Sbjct: 202 AHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDG 237
>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform
5 [Homo sapiens]
Length = 748
Score = 69.3 bits (168), Expect = 8e-12
Identities = 79/294 (26%), Positives = 121/294 (41%), Gaps = 43/294 (14%)
Query: 151 RHRTLTAEEAEEEWER--RNKVLNHFSIMQQRRLKD--------------QDQDEDEEEK 194
RHR ++A EWER R ++ S ++ RL+ Q + +++E+
Sbjct: 102 RHRE-EQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKER 160
Query: 195 EKRG--RRKASELRIHDLEDDLEMSSDASD-ASGEEGGRVPKAKKKAPLAKGGRKKKKKK 251
E+R RRK E R M D SD R P + G +K K+
Sbjct: 161 ERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKE 220
Query: 252 GSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEEPESKAKAPQQEEGPKGVDEQSDSSEES 311
+E SD D E S SSS+ ES + + ++EE + +E+ +SEES
Sbjct: 221 EKMEERDLLSDLQDISDSERKTSSAESSSA----ESGSGSEEEEEEEEEEEEEGSTSEES 276
Query: 312 EEEKPPEEDKEEEEEKKAPTPQEKKRRKDSSEESDSSEESDIDSEASSALFMAKKKTPPK 371
EEE E++EEEEE++ + E+ + + E S+ D + E + L + P
Sbjct: 277 EEE----EEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLV----VPES 328
Query: 372 RERKPSGGSSRGNSRPGTPSAEGGSTSSTLRAAASKLEQGKRVSEMPAAKRLRL 425
R + SG S G EG SS L +G V + PA + L
Sbjct: 329 RFDRDSGESEEAEEEVG----EGTPQSSA-------LTEGDYVPDSPALSPIEL 371
Score = 48.1 bits (113), Expect = 2e-05
Identities = 55/270 (20%), Positives = 109/270 (40%), Gaps = 21/270 (7%)
Query: 158 EEAEEEWERRNKVLNHFSIMQQRRLKDQDQDEDEEEKEKRGRRKASELRIHDLEDDLEMS 217
EE E R + + ++ ++D+ + ED+ K ++ + + ++H +D+
Sbjct: 15 EEGELRDHRMEITIRNSPYRREDSMEDRGE-EDDSLAIKPPQQMSRKEKVHHRKDEKRKE 73
Query: 218 SDASDASGEEGGRVPKAKKKAPLAKGGRKKKKKKGSDDEAFEDSDDGDFEGQEVDYMSDG 277
+ EGG+ + K+K R+ +++K +E +D ++E Q+ M+
Sbjct: 74 KRRHRSHSAEGGKHARVKEKE------REHERRKRHREE--QDKARREWERQKRREMA-R 124
Query: 278 SSSSQEEPESKAKAPQQEEGPKGVDEQSDSSEESEEEKPPEEDKEEEEEKKAPTPQEKKR 337
S +E + ++E K ++Q + E+ E E+ EE ++E E ++ + +
Sbjct: 125 EHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTM 184
Query: 338 RKDSSEESDSSEESDIDSEASSALFMAKKKTPPKRERKPS-----------GGSSRGNSR 386
R+D S++ +S S F P +E K S R S
Sbjct: 185 REDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSS 244
Query: 387 PGTPSAEGGSTSSTLRAAASKLEQGKRVSE 416
+ SAE GS S + E+ SE
Sbjct: 245 AESSSAESGSGSEEEEEEEEEEEEEGSTSE 274
Score = 36.2 bits (82), Expect = 0.074
Identities = 32/161 (19%), Positives = 65/161 (40%), Gaps = 4/161 (2%)
Query: 189 EDEEEKEKRGRRKASELRIHDLEDDLEMSSDASDASGEEGGRVPKAKKKAPLAKGGRKKK 248
+ ++ KR + ELR H +E + S + S E+ G + P + RK+K
Sbjct: 3 QSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEK 62
Query: 249 KKKGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEEPESKAKAPQQEEGPKGVDEQSDSS 308
D++ E + + + E E + + ++++ + E+
Sbjct: 63 VHHRKDEKRKEKRRHRSHSAEGGKHAR--VKEKEREHERRKRHREEQDKARREWERQKRR 120
Query: 309 EESEEEKPPEEDKEEEEEKKAPTPQEKKRRKDSSEESDSSE 349
E + E E D+ E+ E+K +E+K R+ E+ + E
Sbjct: 121 EMAREHSRRERDRLEQLERK--RERERKMREQQKEQREQKE 159
>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
4 [Homo sapiens]
Length = 737
Score = 69.3 bits (168), Expect = 8e-12
Identities = 79/294 (26%), Positives = 121/294 (41%), Gaps = 43/294 (14%)
Query: 151 RHRTLTAEEAEEEWER--RNKVLNHFSIMQQRRLKD--------------QDQDEDEEEK 194
RHR ++A EWER R ++ S ++ RL+ Q + +++E+
Sbjct: 91 RHRE-EQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKER 149
Query: 195 EKRG--RRKASELRIHDLEDDLEMSSDASD-ASGEEGGRVPKAKKKAPLAKGGRKKKKKK 251
E+R RRK E R M D SD R P + G +K K+
Sbjct: 150 ERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKE 209
Query: 252 GSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEEPESKAKAPQQEEGPKGVDEQSDSSEES 311
+E SD D E S SSS+ ES + + ++EE + +E+ +SEES
Sbjct: 210 EKMEERDLLSDLQDISDSERKTSSAESSSA----ESGSGSEEEEEEEEEEEEEGSTSEES 265
Query: 312 EEEKPPEEDKEEEEEKKAPTPQEKKRRKDSSEESDSSEESDIDSEASSALFMAKKKTPPK 371
EEE E++EEEEE++ + E+ + + E S+ D + E + L + P
Sbjct: 266 EEE----EEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLV----VPES 317
Query: 372 RERKPSGGSSRGNSRPGTPSAEGGSTSSTLRAAASKLEQGKRVSEMPAAKRLRL 425
R + SG S G EG SS L +G V + PA + L
Sbjct: 318 RFDRDSGESEEAEEEVG----EGTPQSSA-------LTEGDYVPDSPALSPIEL 360
Score = 29.3 bits (64), Expect = 9.0
Identities = 35/167 (20%), Positives = 57/167 (34%), Gaps = 14/167 (8%)
Query: 276 DGSSSSQEEPESKAKAPQQEEGPKGVDEQSDSSEESEEEKPPEEDKEEEEEK-------- 327
D EE +S A P Q+ K + E++ ++KE E E+
Sbjct: 37 DSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQ 96
Query: 328 -KAPTPQEKKRRKDSSEESDSSEESDIDSEASSALFMAKKKTPPKRERKPSGGSSRGNSR 386
KA E+++R++ + E E ++ K + K +R+ R R
Sbjct: 97 DKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEER 156
Query: 387 PGTPSA--EGGSTSSTLRAAAS---KLEQGKRVSEMPAAKRLRLDTG 428
A E + T+R S K R P +R L G
Sbjct: 157 RKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDG 203
>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
2 [Homo sapiens]
Length = 782
Score = 69.3 bits (168), Expect = 8e-12
Identities = 79/294 (26%), Positives = 121/294 (41%), Gaps = 43/294 (14%)
Query: 151 RHRTLTAEEAEEEWER--RNKVLNHFSIMQQRRLKD--------------QDQDEDEEEK 194
RHR ++A EWER R ++ S ++ RL+ Q + +++E+
Sbjct: 136 RHRE-EQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKER 194
Query: 195 EKRG--RRKASELRIHDLEDDLEMSSDASD-ASGEEGGRVPKAKKKAPLAKGGRKKKKKK 251
E+R RRK E R M D SD R P + G +K K+
Sbjct: 195 ERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKE 254
Query: 252 GSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEEPESKAKAPQQEEGPKGVDEQSDSSEES 311
+E SD D E S SSS+ ES + + ++EE + +E+ +SEES
Sbjct: 255 EKMEERDLLSDLQDISDSERKTSSAESSSA----ESGSGSEEEEEEEEEEEEEGSTSEES 310
Query: 312 EEEKPPEEDKEEEEEKKAPTPQEKKRRKDSSEESDSSEESDIDSEASSALFMAKKKTPPK 371
EEE E++EEEEE++ + E+ + + E S+ D + E + L + P
Sbjct: 311 EEE----EEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLV----VPES 362
Query: 372 RERKPSGGSSRGNSRPGTPSAEGGSTSSTLRAAASKLEQGKRVSEMPAAKRLRL 425
R + SG S G EG SS L +G V + PA + L
Sbjct: 363 RFDRDSGESEEAEEEVG----EGTPQSSA-------LTEGDYVPDSPALSPIEL 405
Score = 48.1 bits (113), Expect = 2e-05
Identities = 55/270 (20%), Positives = 109/270 (40%), Gaps = 21/270 (7%)
Query: 158 EEAEEEWERRNKVLNHFSIMQQRRLKDQDQDEDEEEKEKRGRRKASELRIHDLEDDLEMS 217
EE E R + + ++ ++D+ + ED+ K ++ + + ++H +D+
Sbjct: 49 EEGELRDHRMEITIRNSPYRREDSMEDRGE-EDDSLAIKPPQQMSRKEKVHHRKDEKRKE 107
Query: 218 SDASDASGEEGGRVPKAKKKAPLAKGGRKKKKKKGSDDEAFEDSDDGDFEGQEVDYMSDG 277
+ EGG+ + K+K R+ +++K +E +D ++E Q+ M+
Sbjct: 108 KRRHRSHSAEGGKHARVKEKE------REHERRKRHREE--QDKARREWERQKRREMA-R 158
Query: 278 SSSSQEEPESKAKAPQQEEGPKGVDEQSDSSEESEEEKPPEEDKEEEEEKKAPTPQEKKR 337
S +E + ++E K ++Q + E+ E E+ EE ++E E ++ + +
Sbjct: 159 EHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTM 218
Query: 338 RKDSSEESDSSEESDIDSEASSALFMAKKKTPPKRERKPS-----------GGSSRGNSR 386
R+D S++ +S S F P +E K S R S
Sbjct: 219 REDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSS 278
Query: 387 PGTPSAEGGSTSSTLRAAASKLEQGKRVSE 416
+ SAE GS S + E+ SE
Sbjct: 279 AESSSAESGSGSEEEEEEEEEEEEEGSTSE 308
Score = 32.0 bits (71), Expect = 1.4
Identities = 36/176 (20%), Positives = 65/176 (36%), Gaps = 33/176 (18%)
Query: 233 KAKKKAPLAKGGRKKKKKKGSDDEAFEDSDDGDFEGQEVDYM--------SDGSSSSQEE 284
K ++K K K+ K D + ++G+ ++ D EE
Sbjct: 20 KKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEE 79
Query: 285 PESKA-KAPQQEEGPKGVDEQSD------------SSEESEEEKPPEEDKEEEEEKKAPT 331
+S A K PQQ + V + D S+E + + E+++E E K+
Sbjct: 80 DDSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHRE 139
Query: 332 PQEKKR------------RKDSSEESDSSEESDIDSEASSALFMAKKKTPPKRERK 375
Q+K R R+ S E D E+ + E + +K+ ++ER+
Sbjct: 140 EQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERE 195
>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
Length = 770
Score = 68.6 bits (166), Expect = 1e-11
Identities = 79/294 (26%), Positives = 121/294 (41%), Gaps = 43/294 (14%)
Query: 151 RHRTLTAEEAEEEWER--RNKVLNHFSIMQQRRLKD--------------QDQDEDEEEK 194
RHR ++A EWER R ++ S ++ RL+ Q + +++E+
Sbjct: 124 RHRE-EQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKER 182
Query: 195 EKRG--RRKASELRIHDLEDDLEMSSDASD-ASGEEGGRVPKAKKKAPLAKGGRKKKKKK 251
E+R RRK E R M D SD R P + G +K K+
Sbjct: 183 ERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKE 242
Query: 252 GSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEEPESKAKAPQQEEGPKGVDEQSDSSEES 311
+E SD D E S SSS+ ES + + ++EE + +E+ +SEES
Sbjct: 243 EKMEERDLLSDLQDISDSERKTSSAESSSA----ESGSGSEEEEEEEEEEEEEGSTSEES 298
Query: 312 EEEKPPEEDKEEEEEKKAPTPQEKKRRKDSSEESDSSEESDIDSEASSALFMAKKKTPPK 371
EEE E++EEEEE++ + E+ + + E S+ D + E + L + P
Sbjct: 299 EEE----EEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLV----VPES 350
Query: 372 RERKPSGGSSRGNSRPGTPSAEGGSTSSTLRAAASKLEQGKRVSEMPAAKRLRL 425
R + SG S G EG SS L +G V + PA + L
Sbjct: 351 RFDRDSGESEEAEEEVG----EGTPQSSA-------LTEGDYVPDSPALLPIEL 393
Score = 33.5 bits (75), Expect = 0.48
Identities = 35/162 (21%), Positives = 67/162 (41%), Gaps = 31/162 (19%)
Query: 245 RKKKKKKGSDDEAFEDSDDGDF------EGQEVDYM------------SDGSSSSQEEPE 286
R+K++++ ++ + ++SDD D EG+ D+ D EE +
Sbjct: 22 RRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDRGEEDD 81
Query: 287 SKA-KAPQQEEGPKGVDEQSDSSEESEEEKPPEEDKEEEEEKKAPTPQEKKR-------- 337
S A K PQQ + V + D + + + +++E E K+ Q+K R
Sbjct: 82 SLAIKPPQQMSRKEKVHHRKDEKRKEKWKHARVKEREHERRKRHREEQDKARREWERQKR 141
Query: 338 ----RKDSSEESDSSEESDIDSEASSALFMAKKKTPPKRERK 375
R+ S E D E+ + E + +K+ ++ER+
Sbjct: 142 REMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERE 183
>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
Length = 780
Score = 68.6 bits (166), Expect = 1e-11
Identities = 79/294 (26%), Positives = 121/294 (41%), Gaps = 43/294 (14%)
Query: 151 RHRTLTAEEAEEEWER--RNKVLNHFSIMQQRRLKD--------------QDQDEDEEEK 194
RHR ++A EWER R ++ S ++ RL+ Q + +++E+
Sbjct: 134 RHRE-EQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKER 192
Query: 195 EKRG--RRKASELRIHDLEDDLEMSSDASD-ASGEEGGRVPKAKKKAPLAKGGRKKKKKK 251
E+R RRK E R M D SD R P + G +K K+
Sbjct: 193 ERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKE 252
Query: 252 GSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEEPESKAKAPQQEEGPKGVDEQSDSSEES 311
+E SD D E S SSS+ ES + + ++EE + +E+ +SEES
Sbjct: 253 EKMEERDLLSDLQDISDSERKTSSAESSSA----ESGSGSEEEEEEEEEEEEEGSTSEES 308
Query: 312 EEEKPPEEDKEEEEEKKAPTPQEKKRRKDSSEESDSSEESDIDSEASSALFMAKKKTPPK 371
EEE E++EEEEE++ + E+ + + E S+ D + E + L + P
Sbjct: 309 EEE----EEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLV----VPES 360
Query: 372 RERKPSGGSSRGNSRPGTPSAEGGSTSSTLRAAASKLEQGKRVSEMPAAKRLRL 425
R + SG S G EG SS L +G V + PA + L
Sbjct: 361 RFDRDSGESEEAEEEVG----EGTPQSSA-------LTEGDYVPDSPALLPIEL 403
Score = 39.3 bits (90), Expect = 0.009
Identities = 45/196 (22%), Positives = 80/196 (40%), Gaps = 18/196 (9%)
Query: 156 TAEEAEEEWERRNKVLNHFSIMQQRRLKDQDQDEDEEEKEKRGRRKASELRIHDLEDDLE 215
T +E +E +RR + I +RLK+ D + + + + G ELR H +E +
Sbjct: 12 TLDEILQEKKRRKEQEEKAEI---KRLKNSDDRDSKRDSLEEG-----ELRDHCMEITIR 63
Query: 216 MSSDASDASGEEGGRVPKAKKKAPLAKGGRKKKKKKGSDDEAFEDSDDGDFEGQEVDYMS 275
S + S E+ G + P + RK+K D++ E +
Sbjct: 64 NSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKCRHHSHSAE------ 117
Query: 276 DGSSSSQEEPESKAKAPQQEEGPKGVDE--QSDSSEESEEEKPPEEDKEEEEEKKAPTPQ 333
G + +E E + + +EE K E + E + E E D+ E+ E+K +
Sbjct: 118 GGKHARVKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERK--RER 175
Query: 334 EKKRRKDSSEESDSSE 349
E+K R+ E+ + E
Sbjct: 176 ERKMREQQKEQREQKE 191
>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
8 [Homo sapiens]
Length = 780
Score = 68.2 bits (165), Expect = 2e-11
Identities = 69/268 (25%), Positives = 113/268 (42%), Gaps = 31/268 (11%)
Query: 158 EEAEEEWERRNKVLNHFSIMQQRRLKDQDQDEDEEEKEKRGRRKASELRIHDLEDDLEMS 217
E+ E + ER K+ +QR K++++ +E KE+ RR+ S ED
Sbjct: 167 EQLERKRERERKMREQQK--EQREQKERERRAEERRKEREARREVSAHHRTMRED----Y 220
Query: 218 SDASDASGEEGGRVPKAKKKAPLAKGGRKKKKKKGSDDEAFEDSDDGDFEGQEVDYMSDG 277
SD AS +++ L G + K++K + + D D D
Sbjct: 221 SDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDIS------DSERKT 274
Query: 278 SSSSQEEPESKAKAPQQEEGPKGVDEQSDSSEESEEEKPPEEDKEEEEEKKAPTPQEKKR 337
SS+ ES + + ++EE + +E+ +SEESEEE E++EEEEE++ + E+
Sbjct: 275 SSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEE----EEEEEEEEEETGSNSEEAS 330
Query: 338 RKDSSEESDSSEESDIDSEASSALFMAKKKTPPKRERKPSGGSSRGNSRPGTPSAEGGST 397
+ + E S+ D + E + L + P R + SG S G EG
Sbjct: 331 EQSAEEVSEEEMSEDEERENENHLLV----VPESRFDRDSGESEEAEEEVG----EGTPQ 382
Query: 398 SSTLRAAASKLEQGKRVSEMPAAKRLRL 425
SS L +G V + PA + L
Sbjct: 383 SSA-------LTEGDYVPDSPALSPIEL 403
Score = 42.4 bits (98), Expect = 0.001
Identities = 62/312 (19%), Positives = 115/312 (36%), Gaps = 17/312 (5%)
Query: 156 TAEEAEEEWERRNKVLNHFSIMQQRRLKDQDQDEDEEEKEKRGRRKASELRIHDL----E 211
T +E +E +RR + I + + D+D D E E R E+ I + E
Sbjct: 12 TLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLE-EGELRDHCMEITIRNSPYRRE 70
Query: 212 DDLEMSSDASDASGEEGGRVPKAKKKAPLAKGGRKKKKKKGSDDEAFEDSDDGDFEGQEV 271
D +E + D+ + + K+K K ++K+KK E + + +E
Sbjct: 71 DSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQ 130
Query: 272 DYMSDGSSSSQEEPESKAKAPQQEEGPKGV----DEQSDSSEESEEEKPPEEDKEEEEEK 327
D + Q+ E + ++E G GV D + E E+ E ++E+ E+
Sbjct: 131 D-KARREWERQKRREMAREHSRRERGNDGVCLFRDRLEQLERKRERERKMREQQKEQREQ 189
Query: 328 KAPTPQEKKRRKDSSEESDSSEESDIDSEASSALFMAK--KKTPPKRERKPSGGSSRGNS 385
K + ++RRK+ + S E S A ++PP R P G+
Sbjct: 190 KERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPP---RPPRERFELGDG 246
Query: 386 RPGTPSAEGGSTSSTLRAAASKLEQGKRVSEMPAAKRLRLDTGPQSLSGKSTPQPPSGKT 445
R P E L + + +R + + +G + + + G T
Sbjct: 247 R--KPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGST 304
Query: 446 TPNSGDVQVTED 457
+ S + + E+
Sbjct: 305 SEESEEEEEEEE 316
>gi|48255931 hepatoma-derived growth factor-related protein 2
isoform 1 [Homo sapiens]
Length = 671
Score = 65.1 bits (157), Expect = 1e-10
Identities = 63/243 (25%), Positives = 93/243 (38%), Gaps = 18/243 (7%)
Query: 186 DQDEDEEEKEKRGRRKASELRIHDLEDDLEMSSDASDASGEEGGRVPKAKKKAPLAKGGR 245
D DED+E+ RG + + D +E SD+ +S G K+K P K
Sbjct: 115 DADEDDED---RGVMAVTAVTATAASDRMESDSDSDKSSDNSG-----LKRKTPALKMSV 166
Query: 246 KKKKKKGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEEPESKAKAPQQEEGPKGVDEQS 305
K+ +K S D + E E S+ +S PE KA GP G ++
Sbjct: 167 SKRARKASSDLDQASVSPSEEENSESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKK 226
Query: 306 DSSEESEEEKPPEEDKEEEEEKKAPTPQEKKRRKDSSEESDSSEESDID-SEASSALFMA 364
+ S + D + + + P P R SS S SS +SD+ + A
Sbjct: 227 KAPSAS------DSDSKADSDGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPA 280
Query: 365 KKKTPPKRERKPSGGSSRGNSRPGTPSAEGGSTSSTLR---AAASKLEQGKRVSEMPAAK 421
+K P R RKP +S + S E S R A +LE +R + +
Sbjct: 281 EKPLPKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARRRREQEEELR 340
Query: 422 RLR 424
RLR
Sbjct: 341 RLR 343
Score = 61.6 bits (148), Expect = 2e-09
Identities = 76/334 (22%), Positives = 135/334 (40%), Gaps = 31/334 (9%)
Query: 196 KRGRRKASELRIHDL----EDDLEMSSDASDASGEEGGRVPKAKKKAPLAK--GGRKKKK 249
KR R+ +S+L + E++ E SS++ S ++ KA +AP GGRKKKK
Sbjct: 168 KRARKASSDLDQASVSPSEEENSESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKK 227
Query: 250 K-KGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEEPESKAKAPQQEEGPKGVDEQ--SD 306
SD ++ DSD E + + SSSS +S + G K ++
Sbjct: 228 APSASDSDSKADSDGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKP 287
Query: 307 SSEESEEEKPPEEDKEEEEEKKAPTPQEKKRRKDS-SEESDSSEESDIDSEASSALFMAK 365
+ + E+PP + + + E KRR ++ E ++ + + E K
Sbjct: 288 RGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARRRREQEEELRRLREQEK 347
Query: 366 KKTPPKRERKPSGGSSRGNSRPGTPSAEGGSTSSTLRAAASKLEQGKRVSE---MPAAKR 422
++ +RER G + RG+ GGS+ LR +++ R P++
Sbjct: 348 EEKERRRERADRGEAERGS---------GGSSGDELREDDEPVKKRGRKGRGRGPPSSSD 398
Query: 423 LRLDTGPQSLSGKSTPQPPSGKTTPNSGDVQVTEDAVRRYLTRKPMTTKDLLKKFQTKKT 482
+ + + KS +P S T P Q E VR ++ K +++ + +
Sbjct: 399 SEPEAELEREAKKSAKKPQSSSTEPARKPGQ-KEKRVRPEEKQQAKPVK--VERTRKRSE 455
Query: 483 GLSSEQTVNVLAQILKRLNPERKMINDKMHFSLK 516
G S ++ V K+ P + K+H +K
Sbjct: 456 GFSMDRKVE------KKKEPSVEEKLQKLHSEIK 483
Score = 39.7 bits (91), Expect = 0.007
Identities = 46/204 (22%), Positives = 86/204 (42%), Gaps = 57/204 (27%)
Query: 150 ARHRTLTAEEAEEEWERRNKVLNHFSIMQQRRLKDQDQDEDEEEKEKRGRRKASELRIHD 209
AR R L A E+ E + RRL++Q+++E E +E+ R +A
Sbjct: 322 ARRRELEARRRREQEE------------ELRRLREQEKEEKERRRERADRGEAER----- 364
Query: 210 LEDDLEMSSDASDASGEEGGRVPKAKKKAPLAKGGRKKKKKKGSDDEAFEDSD-DGDFEG 268
+ +SG+E + P+ K GR K +G + DS+ + + E
Sbjct: 365 ---------GSGGSSGDE-----LREDDEPVKKRGR---KGRGRGPPSSSDSEPEAELER 407
Query: 269 QEVDYMSDGSSSSQEEPESKAKAPQQEEGPKGVDEQSDSSEESEEEKPPEEDKEEE---- 324
+ + S ++P+S + P ++ G K E+ EE ++ KP + ++ +
Sbjct: 408 E--------AKKSAKKPQSSSTEPARKPGQK---EKRVRPEEKQQAKPVKVERTRKRSEG 456
Query: 325 -------EEKKAPTPQEKKRRKDS 341
E+KK P+ +EK ++ S
Sbjct: 457 FSMDRKVEKKKEPSVEEKLQKLHS 480
>gi|14249158 hepatoma-derived growth factor-related protein 2
isoform 2 [Homo sapiens]
Length = 670
Score = 65.1 bits (157), Expect = 1e-10
Identities = 63/243 (25%), Positives = 93/243 (38%), Gaps = 18/243 (7%)
Query: 186 DQDEDEEEKEKRGRRKASELRIHDLEDDLEMSSDASDASGEEGGRVPKAKKKAPLAKGGR 245
D DED+E+ RG + + D +E SD+ +S G K+K P K
Sbjct: 115 DADEDDED---RGVMAVTAVTATAASDRMESDSDSDKSSDNSG-----LKRKTPALKMSV 166
Query: 246 KKKKKKGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEEPESKAKAPQQEEGPKGVDEQS 305
K+ +K S D + E E S+ +S PE KA GP G ++
Sbjct: 167 SKRARKASSDLDQASVSPSEEENSESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKK 226
Query: 306 DSSEESEEEKPPEEDKEEEEEKKAPTPQEKKRRKDSSEESDSSEESDID-SEASSALFMA 364
+ S + D + + + P P R SS S SS +SD+ + A
Sbjct: 227 KAPSAS------DSDSKADSDGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPA 280
Query: 365 KKKTPPKRERKPSGGSSRGNSRPGTPSAEGGSTSSTLR---AAASKLEQGKRVSEMPAAK 421
+K P R RKP +S + S E S R A +LE +R + +
Sbjct: 281 EKPLPKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARRRREQEEELR 340
Query: 422 RLR 424
RLR
Sbjct: 341 RLR 343
Score = 61.6 bits (148), Expect = 2e-09
Identities = 76/334 (22%), Positives = 135/334 (40%), Gaps = 31/334 (9%)
Query: 196 KRGRRKASELRIHDL----EDDLEMSSDASDASGEEGGRVPKAKKKAPLAK--GGRKKKK 249
KR R+ +S+L + E++ E SS++ S ++ KA +AP GGRKKKK
Sbjct: 168 KRARKASSDLDQASVSPSEEENSESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKK 227
Query: 250 K-KGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEEPESKAKAPQQEEGPKGVDEQ--SD 306
SD ++ DSD E + + SSSS +S + G K ++
Sbjct: 228 APSASDSDSKADSDGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKP 287
Query: 307 SSEESEEEKPPEEDKEEEEEKKAPTPQEKKRRKDS-SEESDSSEESDIDSEASSALFMAK 365
+ + E+PP + + + E KRR ++ E ++ + + E K
Sbjct: 288 RGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARRRREQEEELRRLREQEK 347
Query: 366 KKTPPKRERKPSGGSSRGNSRPGTPSAEGGSTSSTLRAAASKLEQGKRVSE---MPAAKR 422
++ +RER G + RG+ GGS+ LR +++ R P++
Sbjct: 348 EEKERRRERADRGEAERGS---------GGSSGDELREDDEPVKKRGRKGRGRGPPSSSD 398
Query: 423 LRLDTGPQSLSGKSTPQPPSGKTTPNSGDVQVTEDAVRRYLTRKPMTTKDLLKKFQTKKT 482
+ + + KS +P S T P Q E VR ++ K +++ + +
Sbjct: 399 SEPEAELEREAKKSAKKPQSSSTEPARKPGQ-KEKRVRPEEKQQAKPVK--VERTRKRSE 455
Query: 483 GLSSEQTVNVLAQILKRLNPERKMINDKMHFSLK 516
G S ++ V K+ P + K+H +K
Sbjct: 456 GFSMDRKVE------KKKEPSVEEKLQKLHSEIK 483
Score = 39.7 bits (91), Expect = 0.007
Identities = 46/204 (22%), Positives = 86/204 (42%), Gaps = 57/204 (27%)
Query: 150 ARHRTLTAEEAEEEWERRNKVLNHFSIMQQRRLKDQDQDEDEEEKEKRGRRKASELRIHD 209
AR R L A E+ E + RRL++Q+++E E +E+ R +A
Sbjct: 322 ARRRELEARRRREQEE------------ELRRLREQEKEEKERRRERADRGEAER----- 364
Query: 210 LEDDLEMSSDASDASGEEGGRVPKAKKKAPLAKGGRKKKKKKGSDDEAFEDSD-DGDFEG 268
+ +SG+E + P+ K GR K +G + DS+ + + E
Sbjct: 365 ---------GSGGSSGDE-----LREDDEPVKKRGR---KGRGRGPPSSSDSEPEAELER 407
Query: 269 QEVDYMSDGSSSSQEEPESKAKAPQQEEGPKGVDEQSDSSEESEEEKPPEEDKEEE---- 324
+ + S ++P+S + P ++ G K E+ EE ++ KP + ++ +
Sbjct: 408 E--------AKKSAKKPQSSSTEPARKPGQK---EKRVRPEEKQQAKPVKVERTRKRSEG 456
Query: 325 -------EEKKAPTPQEKKRRKDS 341
E+KK P+ +EK ++ S
Sbjct: 457 FSMDRKVEKKKEPSVEEKLQKLHS 480
>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
Length = 2454
Score = 64.3 bits (155), Expect = 3e-10
Identities = 89/390 (22%), Positives = 163/390 (41%), Gaps = 67/390 (17%)
Query: 44 QARLERDLSNKKIYQEEEMPESGA----GSEFNRKLREEARRKKYGIVLKE-----FRPE 94
+ R R+LS+K+ +E + S + SE N+K ++ KK +++KE R
Sbjct: 1095 ELRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTS 1154
Query: 95 DQPWLLRVNGKSGRKFKGIKKGGVTENTSYYIFTQCPDGAFEAFPVHNWYNFTP------ 148
+ + S + + + E +S Q E + + F
Sbjct: 1155 TKRKQADITSSSSSDIEDDDQNSIGEGSSD---EQKIKPVTENLVLSSHTGFCQSSGDEA 1211
Query: 149 LARHRTLTAEEAEEEWERRNKVLNHFSIMQQRRLKDQDQD---EDEEEKEKRGRRKASEL 205
L++ +T ++ +++ + N++ + + + D+D +DE E+ K+ K +E
Sbjct: 1212 LSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEE 1271
Query: 206 RIHDLEDDLEMSSDASDASGEEGG------RVPKAKKKAPLAKGGRKKKKKKGSDDE--- 256
D E +++S+ SD+ EE R+ + K + G +KK K E
Sbjct: 1272 NPGDEEAKNQVNSE-SDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKG 1330
Query: 257 ------AFEDSDDGDFE----GQEVDYMSDGS-----SSSQEEPESKAKAPQQEEGPKGV 301
+ EDS+D DF+ +EV D S+ + E E ++ +Q++ + +
Sbjct: 1331 RNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRI 1390
Query: 302 DEQSDS-------SEESEEEKPPEEDKEEEEEK---------KAPTPQEKKRRKDSSEES 345
Q DS SEE EEEK EE++EEEEE+ K+P KK RK ++
Sbjct: 1391 KVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDK 1450
Query: 346 DSSEESDIDSEASSALFMAKKKTPPKRERK 375
+E + E ++K +RER+
Sbjct: 1451 LRTETQNALKEEEE-----RRKRIAERERE 1475
Score = 56.2 bits (134), Expect = 7e-08
Identities = 45/201 (22%), Positives = 92/201 (45%), Gaps = 31/201 (15%)
Query: 167 RNKVLNHFSIMQQRRLKDQDQDEDEEEKEKRGRRKASELRIHDLEDDLEMSSDASDASGE 226
R+++L H + ++ + + +E KE +GR + + D + S + + S
Sbjct: 1299 RHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSES 1358
Query: 227 EGGRVPKAK--KKAPLAKGGRK-KKKKKGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQE 283
E + P+ + KKA L + R K+KKK + EDS S+ S+S+E
Sbjct: 1359 EDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSS------------SENKSNSEE 1406
Query: 284 EPESKAKAPQQEEGPKGVDEQSDSSEESEEEKPP-----------EEDKEEEEEKKAPTP 332
E E K + ++EE +E+ + +E+++ K P ++DK E + A
Sbjct: 1407 EEEEKEEEEEEEE-----EEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKE 1461
Query: 333 QEKKRRKDSSEESDSSEESDI 353
+E++R++ + E + + ++
Sbjct: 1462 EEERRKRIAEREREREKLREV 1482
Score = 47.8 bits (112), Expect = 2e-05
Identities = 72/325 (22%), Positives = 129/325 (39%), Gaps = 36/325 (11%)
Query: 190 DEEEKEKRGRRKASELRIHDLEDDLEMSSDASDASGEEGGRVPKAKKKAPLAKGGRKKKK 249
D E+K K+ R K S+ + +L D E S+ D+ KK+ GR+KK+
Sbjct: 1003 DGEKKSKKIRDKTSKKK-DELSDYAEKSTGKGDSCDSS------EDKKSKNGAYGREKKR 1055
Query: 250 KKGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEE-PESKAKAPQQEEGPKGVDEQSDSS 308
K + + D + ++ DG +SS + + + + + E S
Sbjct: 1056 CKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGS 1115
Query: 309 EESEEEKPPEEDKEEEE----EKKAPTPQEKKRR------KDSSEESDSSEESDIDSEAS 358
S+ E+ E++K++++ +KKA +EKKR K + SS SDI+ +
Sbjct: 1116 SSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQ 1175
Query: 359 SALFMAKKKTPPKRERKPSGGSSRGNSRPGTPSAEGGSTSSTLRAAASKLEQGKRVSEMP 418
+++ + + +++ KP + +S G + G S + E
Sbjct: 1176 NSI---GEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENR 1232
Query: 419 AAKRLRLDTGPQSLS----GKSTPQPPSGK------TTPNSGDVQV-----TEDAVRRYL 463
AK++ L+ +LS G S +P GK N GD + +E
Sbjct: 1233 IAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEE 1292
Query: 464 TRKPMTTKDLLKKFQTKKTGLSSEQ 488
++KP LL+ T G S E+
Sbjct: 1293 SKKPRYRHRLLRHKLTVSDGESGEE 1317
Score = 37.0 bits (84), Expect = 0.043
Identities = 77/360 (21%), Positives = 136/360 (37%), Gaps = 40/360 (11%)
Query: 183 KDQDQDEDEEEKEK----RGRRKASELRIHDLEDDLEMSSDASDASGEEGGRVPKAKKKA 238
KD D EDE+ +K +G + + DD E + S EG V K
Sbjct: 807 KDFDSSEDEKHSKKGMDNQGHKNLKTSQ-EGSSDDAERKQERETFSSAEG-TVDKDTTIM 864
Query: 239 PLAKGGRKKKKKKGSDDEAFEDSD-DGDFEGQEVDYMSDGSSSSQEEPESKAKAPQQEEG 297
L KK++ S D + S + F EV +++ S+ K Q +G
Sbjct: 865 ELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQ--DG 922
Query: 298 PKGVDEQ---SDSSEESEEEKPPEEDKEEEEEKKAPTPQEKKRRKDSSEESDSSEESDID 354
+ E+ D S+E+ E+ ++ K+ EEKK P+ +KK K + SS+ ++
Sbjct: 923 LSDIAEKFLKKDQSDETSED-DKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKL 981
Query: 355 SEASSALFMAK----------------KKTPPKRERKPSGGSSRGNSRPGTPSAEGGSTS 398
E K KK K +K S G + S
Sbjct: 982 PEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSED 1041
Query: 399 STLRAAASKLEQGKRVSEMPAAKRLRLDTGPQSLSGKSTPQPPSGKTTPNSGDVQVTEDA 458
+ A E+ KR + + R R Q S T + + NS D ++
Sbjct: 1042 KKSKNGAYGREK-KRCKLLGKSSRKR-----QDCSSSDTEKYSMKEDGCNSSDKRLKRIE 1095
Query: 459 VRRYLTRKPMTTKDLLKKFQTKKTGLSSEQTVNVLAQILKRLNPERK--MINDKMHFSLK 516
+R R+ +++K K+ Q+ + +E++ + +R + ++K ++ +K SL+
Sbjct: 1096 LRE---RRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLR 1152
>gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]
Length = 2492
Score = 64.3 bits (155), Expect = 3e-10
Identities = 89/390 (22%), Positives = 163/390 (41%), Gaps = 67/390 (17%)
Query: 44 QARLERDLSNKKIYQEEEMPESGA----GSEFNRKLREEARRKKYGIVLKE-----FRPE 94
+ R R+LS+K+ +E + S + SE N+K ++ KK +++KE R
Sbjct: 1133 ELRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTS 1192
Query: 95 DQPWLLRVNGKSGRKFKGIKKGGVTENTSYYIFTQCPDGAFEAFPVHNWYNFTP------ 148
+ + S + + + E +S Q E + + F
Sbjct: 1193 TKRKQADITSSSSSDIEDDDQNSIGEGSSD---EQKIKPVTENLVLSSHTGFCQSSGDEA 1249
Query: 149 LARHRTLTAEEAEEEWERRNKVLNHFSIMQQRRLKDQDQD---EDEEEKEKRGRRKASEL 205
L++ +T ++ +++ + N++ + + + D+D +DE E+ K+ K +E
Sbjct: 1250 LSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEE 1309
Query: 206 RIHDLEDDLEMSSDASDASGEEGG------RVPKAKKKAPLAKGGRKKKKKKGSDDE--- 256
D E +++S+ SD+ EE R+ + K + G +KK K E
Sbjct: 1310 NPGDEEAKNQVNSE-SDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKG 1368
Query: 257 ------AFEDSDDGDFE----GQEVDYMSDGS-----SSSQEEPESKAKAPQQEEGPKGV 301
+ EDS+D DF+ +EV D S+ + E E ++ +Q++ + +
Sbjct: 1369 RNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRI 1428
Query: 302 DEQSDS-------SEESEEEKPPEEDKEEEEEK---------KAPTPQEKKRRKDSSEES 345
Q DS SEE EEEK EE++EEEEE+ K+P KK RK ++
Sbjct: 1429 KVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDK 1488
Query: 346 DSSEESDIDSEASSALFMAKKKTPPKRERK 375
+E + E ++K +RER+
Sbjct: 1489 LRTETQNALKEEEE-----RRKRIAERERE 1513
Score = 56.2 bits (134), Expect = 7e-08
Identities = 45/201 (22%), Positives = 92/201 (45%), Gaps = 31/201 (15%)
Query: 167 RNKVLNHFSIMQQRRLKDQDQDEDEEEKEKRGRRKASELRIHDLEDDLEMSSDASDASGE 226
R+++L H + ++ + + +E KE +GR + + D + S + + S
Sbjct: 1337 RHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSES 1396
Query: 227 EGGRVPKAK--KKAPLAKGGRK-KKKKKGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQE 283
E + P+ + KKA L + R K+KKK + EDS S+ S+S+E
Sbjct: 1397 EDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSS------------SENKSNSEE 1444
Query: 284 EPESKAKAPQQEEGPKGVDEQSDSSEESEEEKPP-----------EEDKEEEEEKKAPTP 332
E E K + ++EE +E+ + +E+++ K P ++DK E + A
Sbjct: 1445 EEEEKEEEEEEEE-----EEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKE 1499
Query: 333 QEKKRRKDSSEESDSSEESDI 353
+E++R++ + E + + ++
Sbjct: 1500 EEERRKRIAEREREREKLREV 1520
Score = 47.8 bits (112), Expect = 2e-05
Identities = 72/325 (22%), Positives = 129/325 (39%), Gaps = 36/325 (11%)
Query: 190 DEEEKEKRGRRKASELRIHDLEDDLEMSSDASDASGEEGGRVPKAKKKAPLAKGGRKKKK 249
D E+K K+ R K S+ + +L D E S+ D+ KK+ GR+KK+
Sbjct: 1041 DGEKKSKKIRDKTSKKK-DELSDYAEKSTGKGDSCDSS------EDKKSKNGAYGREKKR 1093
Query: 250 KKGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEE-PESKAKAPQQEEGPKGVDEQSDSS 308
K + + D + ++ DG +SS + + + + + E S
Sbjct: 1094 CKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGS 1153
Query: 309 EESEEEKPPEEDKEEEE----EKKAPTPQEKKRR------KDSSEESDSSEESDIDSEAS 358
S+ E+ E++K++++ +KKA +EKKR K + SS SDI+ +
Sbjct: 1154 SSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQ 1213
Query: 359 SALFMAKKKTPPKRERKPSGGSSRGNSRPGTPSAEGGSTSSTLRAAASKLEQGKRVSEMP 418
+++ + + +++ KP + +S G + G S + E
Sbjct: 1214 NSI---GEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENR 1270
Query: 419 AAKRLRLDTGPQSLS----GKSTPQPPSGK------TTPNSGDVQV-----TEDAVRRYL 463
AK++ L+ +LS G S +P GK N GD + +E
Sbjct: 1271 IAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEE 1330
Query: 464 TRKPMTTKDLLKKFQTKKTGLSSEQ 488
++KP LL+ T G S E+
Sbjct: 1331 SKKPRYRHRLLRHKLTVSDGESGEE 1355
Score = 37.0 bits (84), Expect = 0.043
Identities = 77/360 (21%), Positives = 136/360 (37%), Gaps = 40/360 (11%)
Query: 183 KDQDQDEDEEEKEK----RGRRKASELRIHDLEDDLEMSSDASDASGEEGGRVPKAKKKA 238
KD D EDE+ +K +G + + DD E + S EG V K
Sbjct: 845 KDFDSSEDEKHSKKGMDNQGHKNLKTSQ-EGSSDDAERKQERETFSSAEG-TVDKDTTIM 902
Query: 239 PLAKGGRKKKKKKGSDDEAFEDSD-DGDFEGQEVDYMSDGSSSSQEEPESKAKAPQQEEG 297
L KK++ S D + S + F EV +++ S+ K Q +G
Sbjct: 903 ELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQ--DG 960
Query: 298 PKGVDEQ---SDSSEESEEEKPPEEDKEEEEEKKAPTPQEKKRRKDSSEESDSSEESDID 354
+ E+ D S+E+ E+ ++ K+ EEKK P+ +KK K + SS+ ++
Sbjct: 961 LSDIAEKFLKKDQSDETSED-DKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKL 1019
Query: 355 SEASSALFMAK----------------KKTPPKRERKPSGGSSRGNSRPGTPSAEGGSTS 398
E K KK K +K S G + S
Sbjct: 1020 PEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSED 1079
Query: 399 STLRAAASKLEQGKRVSEMPAAKRLRLDTGPQSLSGKSTPQPPSGKTTPNSGDVQVTEDA 458
+ A E+ KR + + R R Q S T + + NS D ++
Sbjct: 1080 KKSKNGAYGREK-KRCKLLGKSSRKR-----QDCSSSDTEKYSMKEDGCNSSDKRLKRIE 1133
Query: 459 VRRYLTRKPMTTKDLLKKFQTKKTGLSSEQTVNVLAQILKRLNPERK--MINDKMHFSLK 516
+R R+ +++K K+ Q+ + +E++ + +R + ++K ++ +K SL+
Sbjct: 1134 LRE---RRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLR 1190
>gi|224589071 BMS1-like, ribosome assembly protein [Homo sapiens]
Length = 1282
Score = 63.5 bits (153), Expect = 4e-10
Identities = 41/147 (27%), Positives = 71/147 (48%), Gaps = 4/147 (2%)
Query: 201 KASELRIHDLEDDLEMSSDASDASGEEGGRVPKAKKKAPLAKGGRKKKKKKGSDDEAFED 260
K + R+ D + S+ D +G +PK +K+ L G ++K G +DE+ +
Sbjct: 386 KMASSRVTLFSDSKPLGSEDID---NQGLMMPKEEKQMDLNTGRMRRKAIFGDEDESGDS 442
Query: 261 SDDGDFEGQEVDYMSDGSSSSQEEPESKAKAPQQEEGPKGVDEQS-DSSEESEEEKPPEE 319
D+ D E E D + +GSS + E E A+ Q KG+ + + E+SE + P
Sbjct: 443 DDEEDDEMSEDDGLENGSSDEEAEEEENAEMTDQYMAVKGIKRRKLELEEDSEMDLPAFA 502
Query: 320 DKEEEEEKKAPTPQEKKRRKDSSEESD 346
D +++ E+ + E + +SSEE D
Sbjct: 503 DSDDDLERSSAEEGEAEEADESSEEED 529
Score = 44.7 bits (104), Expect = 2e-04
Identities = 65/263 (24%), Positives = 94/263 (35%), Gaps = 53/263 (20%)
Query: 184 DQDQDEDEEEKEKRGRRKASELRIHDLEDDLEMSSDASDASGEEGGRVPKAKKKAPLAKG 243
D D +ED+E E +D LE S +A EE + + KG
Sbjct: 441 DSDDEEDDEMSE---------------DDGLENGSSDEEAEEEENAEM---TDQYMAVKG 482
Query: 244 GRKKKKKKGSDDE----AFEDSDDGDFEGQEVDYMSDGSSSSQEEPESKAKAPQQEEGPK 299
+++K + D E AF DSDD D E S EE + ++ G K
Sbjct: 483 IKRRKLELEEDSEMDLPAFADSDD-DLE------RSSAEEGEAEEADESSEEEDCTAGEK 535
Query: 300 GVDEQSDSSEESEEEKPP---EEDKEEEEE----KKAPTP---------QEKKRRKDSSE 343
G+ + E S+ P + D+ E+ KKA P +E +D SE
Sbjct: 536 GISGSKAAGEGSKAGLSPANCQSDRVNLEKSLLMKKAALPTFDSGHCTAEEVFASEDESE 595
Query: 344 ESDSSEESDIDSEASSALFMAKKKTPPKRERKPSGGSSRGNSRPGTPSAEGGSTSSTLRA 403
ES S + DSE A+ K+ KPS SS P E + L+
Sbjct: 596 ESSSLSAEEEDSENEEAI--------RKKLSKPSQVSSGQKLGPQNFIDETSDIENLLKE 647
Query: 404 AASKLEQGKRVSEMPAAKRLRLD 426
E+ E A + + D
Sbjct: 648 EEDYKEENNDSKETSGALKWKED 670
Score = 38.9 bits (89), Expect = 0.011
Identities = 53/222 (23%), Positives = 81/222 (36%), Gaps = 63/222 (28%)
Query: 183 KDQDQDEDEEEKEKRGRRKASELRIHDLEDDLEMSSDASDASGEEGGRVPKAKKKAPLAK 242
+D+ D D+EE ++ +D LE S +A EE + + K
Sbjct: 436 EDESGDSDDEEDDEMSE-----------DDGLENGSSDEEAEEEENAEMTD---QYMAVK 481
Query: 243 GGRKKKKKKGSDDE----AFEDSDDG-------DFEGQEVDYMSD------------GSS 279
G +++K + D E AF DSDD + E +E D S+ GS
Sbjct: 482 GIKRRKLELEEDSEMDLPAFADSDDDLERSSAEEGEAEEADESSEEEDCTAGEKGISGSK 541
Query: 280 SSQEEPES---------------------KAKAPQQEEGPKGVDE---QSDSSEESEEEK 315
++ E ++ KA P + G +E D SEES
Sbjct: 542 AAGEGSKAGLSPANCQSDRVNLEKSLLMKKAALPTFDSGHCTAEEVFASEDESEESSSLS 601
Query: 316 PPEEDKEEEE--EKKAPTPQEKKRRKDSSEESDSSEESDIDS 355
EED E EE KK P + + ++ E SDI++
Sbjct: 602 AEEEDSENEEAIRKKLSKPSQVSSGQKLGPQNFIDETSDIEN 643
>gi|56118310 nuclear casein kinase and cyclin-dependent kinase
substrate 1 [Homo sapiens]
Length = 243
Score = 62.0 bits (149), Expect = 1e-09
Identities = 59/227 (25%), Positives = 93/227 (40%), Gaps = 15/227 (6%)
Query: 217 SSDASDASGEEGGRVPKAKKKAPLAKGGRKKKKKKGSDDEAFEDSDDGDFEGQEVDYMSD 276
S DA + G + G K + +P +++ K +D EDS+D D + ++ D S
Sbjct: 19 SDDADEDYGRDSGPPTKKIRSSPREAKNKRRSGKNSQEDS--EDSEDKDVKTKKDD--SH 74
Query: 277 GSSSSQEEPESKAKAPQQEEGPKGVDEQSDSSEESEEEKPPEEDKEEEEEKKAPTPQEKK 336
+ S++E E QQ + S E E+ EE++EEE+E AP QEK
Sbjct: 75 SAEDSEDEKEDHKNVRQQRQAASKA--ASKQREMLMEDVGSEEEQEEEDE--APF-QEKD 129
Query: 337 RRKDSSEESDSSEESDIDSEASSALFMAKKKTPPKRERKPSGGSSRGNSRPGTPSAEGGS 396
D + ++SD S M KK P ++E+K + P +G
Sbjct: 130 SGSDEDFLMEDDDDSDYGSSKKKNKKMVKKSKPERKEKKMPKPRLKATVTPSPVKGKG-- 187
Query: 397 TSSTLRAAASKLEQGKRVSEMPAAKRLRLDTGPQSLSGKSTPQPPSG 443
R ASK + K S P + ++ P+ + S P SG
Sbjct: 188 --KVGRPTASKASKEKTPS--PKEEDEEPESPPEKKTSTSPPPEKSG 230
Score = 49.7 bits (117), Expect = 6e-06
Identities = 49/193 (25%), Positives = 84/193 (43%), Gaps = 31/193 (16%)
Query: 185 QDQDEDEEEKEKRGRRKASELRIHDLEDDLEMSSDASDASGEEGGRVPKAKKKAPLAKGG 244
Q+ ED E+K+ + ++ S H ED + D + + A K+ +
Sbjct: 55 QEDSEDSEDKDVKTKKDDS----HSAEDSEDEKEDHKNVRQQRQAASKAASKQREMLMED 110
Query: 245 RKKKKKKGSDDEA-FEDSDDG---DFEGQEVDYMSDGSSSSQEEPESKAKAPQQEEGP-- 298
++++ +DEA F++ D G DF ++ D GSS + + K P+++E
Sbjct: 111 VGSEEEQEEEDEAPFQEKDSGSDEDFLMEDDDDSDYGSSKKKNKKMVKKSKPERKEKKMP 170
Query: 299 ---------------KGVDEQSDSSEESEEE--KPPEEDKEEEE--EKKAPT--PQEKKR 337
KG + +S+ S+E+ P EED+E E EKK T P EK
Sbjct: 171 KPRLKATVTPSPVKGKGKVGRPTASKASKEKTPSPKEEDEEPESPPEKKTSTSPPPEKSG 230
Query: 338 RKDSSEESDSSEE 350
+ S +E+ S E+
Sbjct: 231 DEGSEDEAPSGED 243
>gi|55956788 nucleolin [Homo sapiens]
Length = 710
Score = 61.6 bits (148), Expect = 2e-09
Identities = 43/173 (24%), Positives = 78/173 (45%), Gaps = 21/173 (12%)
Query: 180 RRLKDQDQDEDEEEKEKRGRRKASELRIHDLEDDLEMSSDASDASGEEGGRVPKAKKKAP 239
+ K +D DE+E++ D E+D E D D +E P A K A
Sbjct: 138 KNAKKEDSDEEEDD---------------DSEEDEE---DDEDEDEDEDEIEPAAMKAAA 179
Query: 240 LAKGGRKKKKKKGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEEPESKAKAPQQEEGPK 299
A + + DDE +D ++ D E + ++ + + KAK ++E +
Sbjct: 180 AAPASEDEDDEDDEDDEDDDDDEEDDSEEEAMETTPAKGKKAAKVVPVKAKNVAEDEDEE 239
Query: 300 GVDEQSDSSEESEEEKPPEEDKEEEEEKKAPTPQEK---KRRKDSSEESDSSE 349
DE D ++ ++E +ED EEEEE++ P ++ KR+K+ +++ + E
Sbjct: 240 EDDEDEDDDDDEDDEDDDDEDDEEEEEEEEEEPVKEAPGKRKKEMAKQKAAPE 292
Score = 59.3 bits (142), Expect = 8e-09
Identities = 46/169 (27%), Positives = 72/169 (42%), Gaps = 35/169 (20%)
Query: 184 DQDQDEDEEEKEKRGRRKASELRIHDLEDDLEMSSDASDASGEEGGRVPKAKKKAPLAKG 243
D+D+DEDE+E E + A+ + EDD + D D EE +A + P AKG
Sbjct: 160 DEDEDEDEDEIEPAAMKAAAAAPASEDEDDEDDEDDEDDDDDEEDDSEEEAMETTP-AKG 218
Query: 244 GRK------KKKKKGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEEPESKAKAPQQEEG 297
+ K K D++ ED +D D + E D D
Sbjct: 219 KKAAKVVPVKAKNVAEDEDEEEDDEDEDDDDDEDDEDDD--------------------- 257
Query: 298 PKGVDEQSDSSEESEEEKPPEE---DKEEEEEKKAPTPQEKKRRKDSSE 343
DE + EE EEE+P +E +++E K+ P+ KK++ + +E
Sbjct: 258 ----DEDDEEEEEEEEEEPVKEAPGKRKKEMAKQKAAPEAKKQKVEGTE 302
Score = 55.1 bits (131), Expect = 2e-07
Identities = 39/143 (27%), Positives = 62/143 (43%), Gaps = 25/143 (17%)
Query: 225 GEEGGRVPKAKKKAPLAKGGRKKKKKKGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEE 284
G++G +P K A K +K+ + DD++ ED +D + E ++ D + +
Sbjct: 123 GKKGAAIPA--KGAKNGKNAKKEDSDEEEDDDSEEDEEDDEDEDEDEDEIEPAAM----- 175
Query: 285 PESKAKAPQQEEGPKGVDEQSDSSEESEEEKPPEEDKEEEEEKKAPTPQEKKRRK----- 339
++ A AP E DE + E+ E++ EED EEE + + KK K
Sbjct: 176 -KAAAAAPASE------DEDDEDDEDDEDDDDDEEDDSEEEAMETTPAKGKKAAKVVPVK 228
Query: 340 ------DSSEESDSSEESDIDSE 356
D EE D +E D D E
Sbjct: 229 AKNVAEDEDEEEDDEDEDDDDDE 251
Score = 50.4 bits (119), Expect = 4e-06
Identities = 37/131 (28%), Positives = 52/131 (39%), Gaps = 12/131 (9%)
Query: 232 PKAKKKAPLAKGGRKKKKKKGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEEPESKAKA 291
P K A AKG + K K D + ED D + E + D D ++ A A
Sbjct: 122 PGKKGAAIPAKGAKNGKNAKKEDSDEEEDDDSEEDEEDDEDEDEDEDEIEPAAMKAAAAA 181
Query: 292 PQQEEGPKGVDEQSDSSEESEEEKPPEEDKEEEEEKKAPTPQEKKRRK------DSSEES 345
P E DE + E+ E++ EED EEE + + KK K + E
Sbjct: 182 PASE------DEDDEDDEDDEDDDDDEEDDSEEEAMETTPAKGKKAAKVVPVKAKNVAED 235
Query: 346 DSSEESDIDSE 356
+ EE D D +
Sbjct: 236 EDEEEDDEDED 246
Score = 43.5 bits (101), Expect = 5e-04
Identities = 42/207 (20%), Positives = 81/207 (39%), Gaps = 30/207 (14%)
Query: 183 KDQDQDEDEEEK---------EKRGRRKASELRIHDLEDDLEMSSDASDAS------GEE 227
+D++ EDEE+ +K+G++ A+ + + + A+ A G++
Sbjct: 29 EDEEMSEDEEDDSSGEEVVIPQKKGKKAAATSAKKVVVSPTKKVAVATPAKKAAVTPGKK 88
Query: 228 GGRVPKAKKKAPLAKGGRKKKKKKGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEEPES 287
P AKK AK KK + +A + +G ++ +E+ +
Sbjct: 89 AAATP-AKKTVTPAKAVTTPGKKGATPGKALVATPGKKGAAIPAKGAKNGKNAKKEDSDE 147
Query: 288 KAKAPQQEEGPKGVDEQSDSSEESEEEKPPEEDKEEEEEKKAPTPQEKKRRKDSSEESDS 347
+E DS E+ E+++ +ED++E E +D +E D
Sbjct: 148 --------------EEDDDSEEDEEDDEDEDEDEDEIEPAAMKAAAAAPASEDEDDEDDE 193
Query: 348 SEESDIDSEASSALFMAKKKTPPKRER 374
+E D D E + A + TP K ++
Sbjct: 194 DDEDDDDDEEDDSEEEAMETTPAKGKK 220
Score = 31.2 bits (69), Expect = 2.4
Identities = 28/124 (22%), Positives = 53/124 (42%), Gaps = 16/124 (12%)
Query: 289 AKAPQQEEGPKGVDEQSDSSEESEEEKPPEEDKEEE---EEKKAPTPQEKKRRKDSSEE- 344
AKA + + PK + EE E++ ED+E++ EE P + KK S+++
Sbjct: 5 AKAGKNQGDPKKMAPPPKEVEEDSEDEEMSEDEEDDSSGEEVVIPQKKGKKAAATSAKKV 64
Query: 345 ----------SDSSEESDIDSEASSALFMAKKKTPPKRERKPSG--GSSRGNSRPGTPSA 392
+ ++++ + +A AKK P + G G++ G + TP
Sbjct: 65 VVSPTKKVAVATPAKKAAVTPGKKAAATPAKKTVTPAKAVTTPGKKGATPGKALVATPGK 124
Query: 393 EGGS 396
+G +
Sbjct: 125 KGAA 128
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 61.6 bits (148), Expect = 2e-09
Identities = 77/348 (22%), Positives = 142/348 (40%), Gaps = 32/348 (9%)
Query: 159 EAEEEWERRNKVLNHFSIMQQRRLKDQDQDEDEEEKEKRGRRKASELRIHDLEDDLEMSS 218
++EE+ + K I++++ + Q +E EE+EK + + + E++ E
Sbjct: 439 KSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGE 498
Query: 219 DASDASGEEGGRVPKAKKKAPLAKGGRKKKKKKGSDDEAFEDSDDGDFEGQEVDYMSDGS 278
+ + + E P+ + K+P+ + + + K + E + EV
Sbjct: 499 EETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSP-------AEVKSPEKAK 551
Query: 279 SSSQEEPES--KAKAPQQEEGPKGVDEQSDSSEES---EEEKPPEEDKEEEEEKKAPTPQ 333
S ++EE +S +AK+P++EE + +S +S EE K P E K E KA +P
Sbjct: 552 SPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPE---KAKSPV 608
Query: 334 EKKRRKDSSEESDSSEESDIDSEASSALFMAKKKTPPKRERK-------PSGGSSRGNSR 386
+++ + + +S EE+ +E S K K+P K E K P ++ +
Sbjct: 609 KEEAKSPAEAKSPVKEEAKSPAEVKSP---EKAKSPTKEEAKSPEKAKSPEKEEAKSPEK 665
Query: 387 PGTP-SAEGGS---TSSTLRAAASKLEQGKR--VSEMPAAKRLRLDTGPQSLSGKSTPQP 440
+P AE S S ++A A E+ K E + ++ + ++ S + P
Sbjct: 666 AKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSP 725
Query: 441 PSGKT-TPNSGDVQVTEDAVRRYLTRKPMTTKDLLKKFQTKKTGLSSE 487
+ TP V E+A + P K L K KT E
Sbjct: 726 VKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEE 773
Score = 56.2 bits (134), Expect = 7e-08
Identities = 57/252 (22%), Positives = 111/252 (44%), Gaps = 31/252 (12%)
Query: 170 VLNHFSIMQQRRLKDQDQDEDEEE--KEKRGRRKASELRIHDLEDDLEMSSDASDASGEE 227
V H + + ++K ++ E E +E+ + +E ++ ++ E + + EE
Sbjct: 432 VSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTE----EVTEEEEKEAKEEEGKEEE 487
Query: 228 GGRVPKAKKKAPLAKGGRKKKKKKGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEEPES 287
GG +A+ GG ++ K +++ A + + +E ++ S +EE
Sbjct: 488 GGEEEEAE-------GGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEE--- 537
Query: 288 KAKAPQQEEGPKGVDEQSDSSEESEEEKPPEEDKEEEEEKKAP--TPQEKKRRKDSSEES 345
AK+P + + P E++ S + E + PPE E+EE K+P +K + + EE+
Sbjct: 538 -AKSPAEVKSP----EKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEA 592
Query: 346 DSSEESDIDSEASS-----ALFMAKKKTPPKRERKPSGGSSRGNSRPGTPSAEGGSTSST 400
S E+ +A S A A+ K+P K E K S + + +P+ E S
Sbjct: 593 KSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAK-SPAEVKSPEKAKSPTKE--EAKSP 649
Query: 401 LRAAASKLEQGK 412
+A + + E+ K
Sbjct: 650 EKAKSPEKEEAK 661
Score = 55.1 bits (131), Expect = 2e-07
Identities = 85/406 (20%), Positives = 150/406 (36%), Gaps = 62/406 (15%)
Query: 154 TLTAEEAEEEWERRNKVLNHFSIMQQRRLKDQDQDEDEEEKEKRGRRKASELRIHDLEDD 213
T+ EE EE + +V +++ K+++ E+E +E+ E + E+
Sbjct: 454 TVIVEEQTEETQVTEEVTEE----EEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEA 509
Query: 214 LEMSSDASDASGEEGGRVPKAKK------KAPLAKGGRKKKKKKGSDD-----EAFEDSD 262
+A EE +AK K+P +K K ++ EA
Sbjct: 510 ASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEK 569
Query: 263 DGDFEGQEVDYMSDGSSSSQEEPES--------KAKAPQQEEGPKGVDEQSDSSEES--- 311
+ EV S ++EE +S KAK+P +EE + +S EE+
Sbjct: 570 EEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSP 629
Query: 312 --------------EEEKPPEEDKEEEEEKKAPTPQEKKRRKDSSEESDSSEESDIDSEA 357
EE K PE+ K E+E +A +P++ K + +S +S + +EA
Sbjct: 630 AEVKSPEKAKSPTKEEAKSPEKAKSPEKE-EAKSPEKAKSPVKAEAKSPEKAKSPVKAEA 688
Query: 358 SSALFMAKKKTPPKRERK-------PSGGSSRGNSRPGTPSAEGGSTSSTLRAAASKLEQ 410
S K K+P K E K P ++ + +P E T ++ + +
Sbjct: 689 KSP---EKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAK 745
Query: 411 GKRVSEMP-AAKRLRLDTGPQSLSGKSTPQPPSGK-----TTPNSGDVQVTEDAVRRYLT 464
++ P AK L + + K + P+ K +P +V+ E A
Sbjct: 746 SPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKE 805
Query: 465 RKPMTTKDLLKKFQTKKTGLSSEQTVNVLAQILKRLNPERKMINDK 510
K++ KK + K E+ Q +K P +K +K
Sbjct: 806 DAKAPEKEIPKKEEVKSPVKEEEK-----PQEVKVKEPPKKAEEEK 846
Score = 52.8 bits (125), Expect = 8e-07
Identities = 38/166 (22%), Positives = 78/166 (46%), Gaps = 5/166 (3%)
Query: 185 QDQDEDEEEKEKRGRRKASELRIHDLEDDLEMSSDASDASGEEGGRVPKAKKKAPLAKGG 244
+D ++E K++ + K E + +E E +A E+ +VP +K+AP
Sbjct: 857 KDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEV 916
Query: 245 RKKKKKKGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEEPESK-AKAPQQEEGPKGVDE 303
++ K K + A ++ DD + +E ++ ++ E+ ++K KA + EE PK E
Sbjct: 917 KEDAKPKEKTEVAKKEPDDA--KAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPK--TE 972
Query: 304 QSDSSEESEEEKPPEEDKEEEEEKKAPTPQEKKRRKDSSEESDSSE 349
++ K P + K E+ EK + T Q+ + + + E +++
Sbjct: 973 AKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDKAAK 1018
Score = 49.7 bits (117), Expect = 6e-06
Identities = 52/217 (23%), Positives = 92/217 (42%), Gaps = 36/217 (16%)
Query: 185 QDQDEDEEEKEKRGRRKASELRIHDLEDDLEMSSDASDASGEEGGRVPKAKKKAPLAKGG 244
+++++ +E K K +KA E + + + D+ EE KK+AP K
Sbjct: 825 KEEEKPQEVKVKEPPKKAEE----EKAPATPKTEEKKDSKKEEA-----PKKEAPKPKVE 875
Query: 245 RKKKKKKGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEEPESKAKAPQQE-EGPKGVDE 303
KK + A E + E + +EE E K K P E E P V+
Sbjct: 876 EKK-------EPAVEKPKESKVE------------AKKEEAEDKKKVPTPEKEAPAKVEV 916
Query: 304 QSDSSEESEEE---KPPEEDKEEEEEKKAPTPQEKKRRKDSSEESDSSEESDIDSEASSA 360
+ D+ + + E K P++ K +E K A + +KD+ EE E +EA +
Sbjct: 917 KEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAK 976
Query: 361 ---LFMAKKKTPPKRER-KPSGGSSRGNSRPGTPSAE 393
++K+ + PK E+ + S + + +S+P + E
Sbjct: 977 EDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATE 1013
Score = 46.2 bits (108), Expect = 7e-05
Identities = 49/221 (22%), Positives = 90/221 (40%), Gaps = 29/221 (13%)
Query: 222 DASGEEGGRVPKAKKKAPLAKGGRKKKKKKGSDDEAFEDSDDGDFEGQEVDYMSDGSSSS 281
DA E K + K+P+ K+++K + + E + E ++ S
Sbjct: 806 DAKAPEKEIPKKEEVKSPV------KEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDS 859
Query: 282 QEEPESKAKAPQ---QEEGPKGVDEQSDSSEESEEEKPPEEDKEEEEEKKAPTPQEKKRR 338
++E K +AP+ +E+ V++ +S E+++E+ ++ K EK+AP E K
Sbjct: 860 KKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKED 919
Query: 339 KDSSEESDSSEESDIDSEASSALFMAKKK------------------TPPKRERKPSGGS 380
E+++ +++ D++A A+KK PK E K
Sbjct: 920 AKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDD 979
Query: 381 SRGNSRPGTPSAEGGSTSSTLRAAASKLEQGKRVSEMPAAK 421
+ P P AE SS+ SK ++ +E AAK
Sbjct: 980 KTLSKEPSKPKAEKAEKSSSTDQKDSK--PPEKATEDKAAK 1018
Score = 43.9 bits (102), Expect = 4e-04
Identities = 57/275 (20%), Positives = 113/275 (41%), Gaps = 41/275 (14%)
Query: 182 LKDQDQDEDEEEKEKRGRRKASELRIHDLEDDLEMSSDASDASGEEGGRVPKAKK----- 236
+K++ + ++ + + K+ E ++++ + A EE KAK
Sbjct: 698 VKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAK 757
Query: 237 ----KAPLAKGGRKKKKKKGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEEPESKAKA- 291
K+P AK K++ + +D F + + +EV S +E+ ++ K
Sbjct: 758 TLDVKSPEAKTPAKEEARSPADK--FPEKAKSPVK-EEVKSPEKAKSPLKEDAKAPEKEI 814
Query: 292 PQQEEGPKGVDEQSDSSE--------ESEEEKPPE----EDKEEEEEKKAPTPQEKKRRK 339
P++EE V E+ E ++EEEK P E+K++ ++++AP + K +
Sbjct: 815 PKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKV 874
Query: 340 DSSEES--DSSEESDIDSEASSALFMAKKKTPP---------KRERKPSGGSSRGNSRPG 388
+ +E + +ES ++++ A K TP K + KP + P
Sbjct: 875 EEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPD 934
Query: 389 TPSAEGGSTSSTLRAAA-----SKLEQGKRVSEMP 418
A+ S + + AA +K E+ K+ E P
Sbjct: 935 DAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKP 969
Score = 40.8 bits (94), Expect = 0.003
Identities = 37/189 (19%), Positives = 73/189 (38%), Gaps = 15/189 (7%)
Query: 288 KAKAPQQEEGPKGVDEQSDSSEESEEEKPPEEDKEEEEEKKAPTPQEKKRRKDSSEESDS 347
K K+ ++ + + ++++ EE EE E+ EEEEK+A + K+ EE++
Sbjct: 437 KVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEG 496
Query: 348 SEESDIDSEASSALFMAKKKTPPKRERKPSGGSSRGNSRPGTPSAEGGSTSSTLRAAASK 407
EE A A +P K + P ++ + +P E + + +++
Sbjct: 497 GEEETKSPPAEEA------ASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKA 550
Query: 408 LEQGKRVSEMPAAKRLRLDTGPQSLSGKSTPQPPSGKTTPNSGDVQVTEDAVRRYLTRKP 467
K ++ P + P+ KS P+ +P E+A + P
Sbjct: 551 KSPAKEEAKSPPEAK-----SPEKEEAKS----PAEVKSPEKAKSPAKEEAKSPAEAKSP 601
Query: 468 MTTKDLLKK 476
K +K+
Sbjct: 602 EKAKSPVKE 610
>gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens]
Length = 494
Score = 61.2 bits (147), Expect = 2e-09
Identities = 53/258 (20%), Positives = 97/258 (37%), Gaps = 15/258 (5%)
Query: 181 RLKDQDQDEDEEEKEKRGRRKASELRIHDLEDDLEMSSDASDASGEEGGRVPKAKKKAPL 240
R + Q + ++EK + ++ S R H S D ++ + V K K ++P
Sbjct: 233 RSRSQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNVGKPKSRSP- 291
Query: 241 AKGGRKKKKKKGSDDEAFEDSDDGDFE---GQEVDYMSDGSSS-----SQEEPESKAKAP 292
++ K K + S + E+ G QE S S S+ S++K+
Sbjct: 292 SRHKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSKGGSRSRSRSRSKSK 351
Query: 293 QQEEGPKGVDEQSDSSEESEEEKPPEEDKEEEEEKKAPTPQEKKR------RKDSSEESD 346
+ +G K E+S S S + + + + KA + ++KK+ + S S
Sbjct: 352 DKRKGRKRSREESRSRSRSRSKSERSRKRGSKRDSKAGSSKKKKKEDTDRSQSRSPSRSV 411
Query: 347 SSEESDIDSEASSALFMAKKKTPPKRERKPSGGSSRGNSRPGTPSAEGGSTSSTLRAAAS 406
S E SE+S + + + S S S+P PS + S + +
Sbjct: 412 SKEREHAKSESSQREGRGESENAGTNQETRSRSRSNSKSKPNLPSESRSRSKSASKTRSR 471
Query: 407 KLEQGKRVSEMPAAKRLR 424
+ + S P+ R R
Sbjct: 472 SKSRSRSASRSPSRSRSR 489
Score = 38.9 bits (89), Expect = 0.011
Identities = 51/237 (21%), Positives = 89/237 (37%), Gaps = 41/237 (17%)
Query: 150 ARHRTLTAEEAEEEWERRNKVLNHFSIMQQRRLKDQDQDEDEEEKEKRGRRKASELRIHD 209
++ R+ + E EE +R + R+ + + + + R R K+ + R
Sbjct: 298 SKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSKGGSRSRSRSRSKSKDKRKGR 357
Query: 210 LEDDLEMSSDASDASGEEGGRVPKAKKKAPLAKGGRKKKKKKGSDDEAFEDSDDGDFEGQ 269
E S + S E R +K+ + K G KKKKK ED+D
Sbjct: 358 KRSREESRSRSRSRSKSERSRKRGSKRDS---KAGSSKKKKK-------EDTDRSQSR-- 405
Query: 270 EVDYMSDGSSSSQEEPESKAKAPQQEEGPKGVDEQSDSSEESEEEKPPEEDKEEEEEKKA 329
S S S+E +K+++ Q+E +G E + +++E+ + K
Sbjct: 406 -----SPSRSVSKEREHAKSESSQRE--GRGESENAGTNQETRSR------SRSNSKSKP 452
Query: 330 PTPQEKKRRKDSSEESDSSEESDIDSEASSALFMAKKKTPPKRERKPSGGSSRGNSR 386
P E + R S+ ++ S +S S + R PS SR +SR
Sbjct: 453 NLPSESRSRSKSASKTRSRSKSRSRSAS----------------RSPSRSRSRSHSR 493
Score = 34.7 bits (78), Expect = 0.22
Identities = 35/164 (21%), Positives = 64/164 (39%), Gaps = 16/164 (9%)
Query: 275 SDGSSSSQEEPESKAKAPQQEEGPKGVDEQSDSSEESEEEKPPEEDKEEEEEKKAPTPQE 334
S S SS + S++++ + QS S + E+ + P ++K A +
Sbjct: 208 SGSSKSSHSKSRSRSRSGSRSRSKSRSRSQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRS 267
Query: 335 KKRRKDSSEES-DSSEESDIDSEASSALFMAKKKTPPKR-----ERKPSGGSSRG----- 383
K KD +EE +++ S + +K K+ + E + G SRG
Sbjct: 268 KS--KDQAEEKIQNNDNVGKPKSRSPSRHKSKSKSRSRSQERRVEEEKRGSVSRGRSQEK 325
Query: 384 ---NSRPGTPSAEGGSTSSTLRAAASKLEQGKRVSEMPAAKRLR 424
SR + S G + S R+ + +G++ S + R R
Sbjct: 326 SLRQSRSRSRSKGGSRSRSRSRSKSKDKRKGRKRSREESRSRSR 369
>gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1
[Homo sapiens]
Length = 651
Score = 61.2 bits (147), Expect = 2e-09
Identities = 69/320 (21%), Positives = 134/320 (41%), Gaps = 56/320 (17%)
Query: 180 RRLKDQDQDEDEEEKEKRGRRKASELRIHDLEDDLEMSSDASDA-SGE-EGGRVPKAKKK 237
++ D + ++ ++ K K ++ ++ D + D++ ++++DA SG+ + R K K
Sbjct: 293 KKSSDAESEDSKDAK-KDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDK 351
Query: 238 APLAKGGRKKKKKK---------GSDDEAFEDS---------DDGDFEGQEVDYMSDG-- 277
L K +KK KK G +A DS DD + +++ + +D
Sbjct: 352 KKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSES 411
Query: 278 --SSSSQEEPESKAKAPQQEEGPKGVDEQSDSSEESEEEKPPEEDKEEEEEKKAPTPQEK 335
S ++ E K K + + K V +S++ E K + +++E+K ++
Sbjct: 412 ELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKD 471
Query: 336 KRRKDSSEESDSSE-ESDI-------------------------DSEASSALFMAKKKTP 369
++KD+ + ++S+E ESD+ D+E++ A F KT
Sbjct: 472 DKKKDAKKNAESTEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTG 531
Query: 370 PKRERKPSGGSSRGNSRPGTPSAEGGSTSSTLRAAASKLE--QGKRVSEMPAAKRLRLDT 427
K K G + P A+ S +A SK+E + KR M + K +
Sbjct: 532 FKTSTKIKGSDTESEESLYKPGAKKKIDESDGTSANSKMEGLESKRGFRMSSKKTTFNEK 591
Query: 428 GPQSLSGKSTPQPPSGKTTP 447
G ++ +G+ PPS + P
Sbjct: 592 GEKASTGR---VPPSREKPP 608
Score = 56.2 bits (134), Expect = 7e-08
Identities = 64/305 (20%), Positives = 126/305 (41%), Gaps = 29/305 (9%)
Query: 187 QDEDEEEKEKRGRRKASELRIHDLEDDLEMSSDASDA-SGEEGGRVPKAKK-KAPLAKGG 244
+ ED ++ +K ++ ++ D + D++ ++++DA SG+ KK K L K
Sbjct: 299 ESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDD 358
Query: 245 RKKKKKKGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEEPESKAKAPQQEEGPKGVDEQ 304
+KK KK + D++ GD + ++ + + KA + ++ K +
Sbjct: 359 KKKDTKKYPEST---DTESGD------------AKDARNDSRNLKKASKNDDKKKDAKKI 403
Query: 305 SDSSEESEEEKPPEEDKEEEEEKKAPTPQEKKRRKDSSEESDSSEESDIDSEASSALFMA 364
+ S++ E + E K+E+++KK KK K+ E +D+ E DS+
Sbjct: 404 TFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSK-------- 455
Query: 365 KKKTPPKRERKPSGGSSRGNSRPGTPSAEGGSTSSTLRAAASKL-EQGKRVSEMPAAKRL 423
K K K+ +K S + + +AE S L K + K+ S+ K
Sbjct: 456 KGKKDEKKGKKDSKKDDK--KKDAKKNAESTEMESDLELKKDKKHSKEKKGSKKDIKKDA 513
Query: 424 RLDTGPQSLSGKSTPQPPSGKTTPNSGDVQVTEDAVRRYLTRKPMTTKDLLKKFQTKKTG 483
R DT + + +T G +E+++ + +K + D +K G
Sbjct: 514 RKDTESTDAEFDESSKTGFKTSTKIKGSDTESEESLYKPGAKKKIDESDGTSA-NSKMEG 572
Query: 484 LSSEQ 488
L S++
Sbjct: 573 LESKR 577
Score = 47.0 bits (110), Expect = 4e-05
Identities = 33/174 (18%), Positives = 71/174 (40%), Gaps = 3/174 (1%)
Query: 211 EDDLEMSSDASDASGEEGGRVPKAKKKAPLAKGGRKKKKKKG-SDDEAFEDSDDGDFEGQ 269
+D + + +SDA E+ K KK + K +K KKK D D++ GD + +
Sbjct: 286 KDTKKNAKKSSDAESEDSKDAKKDSKK--VKKNVKKDDKKKDVKKDTESTDAESGDSKDE 343
Query: 270 EVDYMSDGSSSSQEEPESKAKAPQQEEGPKGVDEQSDSSEESEEEKPPEEDKEEEEEKKA 329
D D +++ + K + + D + ++ +K + D ++++ KK
Sbjct: 344 RKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKI 403
Query: 330 PTPQEKKRRKDSSEESDSSEESDIDSEASSALFMAKKKTPPKRERKPSGGSSRG 383
+ + +S E ++ DS+ + + + + +P G S +G
Sbjct: 404 TFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKG 457
Score = 33.1 bits (74), Expect = 0.63
Identities = 23/104 (22%), Positives = 50/104 (48%), Gaps = 10/104 (9%)
Query: 288 KAKAPQQEEGPKGVDEQSDSSEE------SEEEKPPEEDKEEEEEKKAPTPQEKKRRKDS 341
KA+ + ++ G + DS ++ + E K E+K + + + TP + +
Sbjct: 112 KAEYKKSKDEKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKSSHENEQ 171
Query: 342 SEESDSSEESDIDSEASSALFMAKKKTPPKRERKPSGGSSRGNS 385
S++S SS E++ +S+ S + K ++++K S S + N+
Sbjct: 172 SKKSKSSSETNPESQNSKTV----SKNCSQKDKKDSKNSKKTNT 211
Score = 33.1 bits (74), Expect = 0.63
Identities = 42/268 (15%), Positives = 94/268 (35%), Gaps = 15/268 (5%)
Query: 176 IMQQRRLKDQDQDE----DEEEKEKRGRRKASELRIHDLEDDLEMSSDASDASGEEGGRV 231
I++++ + + D+ E E+ + K+S + ++ +S + S ++
Sbjct: 147 IVEEKTKRQNEADKTPLKSSHENEQSKKSKSSSETNPESQNSKTVSKNCSQKDKKDSKNS 206
Query: 232 PKAKKKAPLAKGGRKK--KKKKGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEEPESKA 289
K + K KK K+ K S+D E + VD++ S E A
Sbjct: 207 KKTNTEFLHTKNNPKKDLKRSKTSNDPISEICSENSLN---VDFLMLVGQSDDESINFDA 263
Query: 290 KAPQQEEGP------KGVDEQSDSSEESEEEKPPEEDKEEEEEKKAPTPQEKKRRKDSSE 343
+ K ++++ ++ E ++ ++ KK +K +KD +
Sbjct: 264 WLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKK 323
Query: 344 ESDSSEESDIDSEASSALFMAKKKTPPKRERKPSGGSSRGNSRPGTPSAEGGSTSSTLRA 403
+ + D+E+ + K K++ K P + E G
Sbjct: 324 KDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARND 383
Query: 404 AASKLEQGKRVSEMPAAKRLRLDTGPQS 431
+ + + K + AK++ T +S
Sbjct: 384 SRNLKKASKNDDKKKDAKKITFSTDSES 411
>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
Length = 1301
Score = 60.8 bits (146), Expect = 3e-09
Identities = 45/223 (20%), Positives = 77/223 (34%), Gaps = 9/223 (4%)
Query: 186 DQDEDEEEKEKRGRRKASELRIHDLEDDLEMSSDASDASGEEGGRVPKAKKKAPLAKGGR 245
D D + + +S+ D SSD+SD+S + +K ++ +
Sbjct: 579 DSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDS 638
Query: 246 KKKKKKGSDDEAFEDSDDGDFEGQ----EVDYMSDGSSSSQEEPESKAKAPQQEEGPKGV 301
K + ++ ++SD D + SD S SS S +
Sbjct: 639 KSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNS 698
Query: 302 DEQSDSSEESEEEKPPEEDKE-----EEEEKKAPTPQEKKRRKDSSEESDSSEESDIDSE 356
E SDSS+ S+ + D + + + + DSS+ SDSS SD
Sbjct: 699 SESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDS 758
Query: 357 ASSALFMAKKKTPPKRERKPSGGSSRGNSRPGTPSAEGGSTSS 399
+ S+ + + S SS N + + S SS
Sbjct: 759 SDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSS 801
Score = 57.0 bits (136), Expect = 4e-08
Identities = 44/216 (20%), Positives = 73/216 (33%), Gaps = 3/216 (1%)
Query: 184 DQDQDEDEEEKEKRGRRKASELRIHDLEDDLEMSSDASDASGEEGGRVPKAKKKAPLAKG 243
D D D + G +D D + SD+SD+ + + +
Sbjct: 514 DSDSTSDTNNSDSNGNGNNGN-DDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSS 572
Query: 244 GRKKKKKKGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEEPESKAKAPQQEEGPKGVDE 303
S D DS D D S SS S + +S + + + K +
Sbjct: 573 DSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESD 632
Query: 304 QSDSSEESEEEKPPEEDKEEEEEKKAPTPQEKKRRKDSSEESDSSEESDIDSEASSALFM 363
SDS +S+ D + + + DSS+ SDSS+ S ++S+
Sbjct: 633 SSDSDSKSDSSDSNSSDSSDNSD--SSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSS 690
Query: 364 AKKKTPPKRERKPSGGSSRGNSRPGTPSAEGGSTSS 399
+ E S SS +S + S+ S+ S
Sbjct: 691 DSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDS 726
Score = 56.6 bits (135), Expect = 5e-08
Identities = 50/264 (18%), Positives = 90/264 (34%), Gaps = 3/264 (1%)
Query: 186 DQDEDEEEKEKRGRRKASELRIHDLEDDLEMSSDASDASGEEGGRVPKAKKKAPLAKGGR 245
D D + S+ D SSD+SD+S + +
Sbjct: 709 DSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSS 768
Query: 246 KKKKKKGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEEPESKAKAPQQEEGPKGVDEQS 305
S D + SD D S SS S +S + + + S
Sbjct: 769 DSSDSSDSSDSS-NSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSS 827
Query: 306 DSSEESEEEKPPEEDKEEEEEKKAPTPQEKKRRKDSSEESDSSEESDIDSEASSALFMAK 365
+SS+ S+ D + + + + R DSS SDSS+ SD + + S+
Sbjct: 828 NSSDSSDSSN--SSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDS 885
Query: 366 KKTPPKRERKPSGGSSRGNSRPGTPSAEGGSTSSTLRAAASKLEQGKRVSEMPAAKRLRL 425
++ + S SS +S + S++ +S++ ++ S S +
Sbjct: 886 NESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSS 945
Query: 426 DTGPQSLSGKSTPQPPSGKTTPNS 449
D+ S S S+ S ++ +S
Sbjct: 946 DSSDSSNSSDSSNSSDSSNSSDSS 969
Score = 56.2 bits (134), Expect = 7e-08
Identities = 42/237 (17%), Positives = 83/237 (35%)
Query: 213 DLEMSSDASDASGEEGGRVPKAKKKAPLAKGGRKKKKKKGSDDEAFEDSDDGDFEGQEVD 272
D SSD+SD+S G + ++ + S+ DS D + D
Sbjct: 834 DSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSD 893
Query: 273 YMSDGSSSSQEEPESKAKAPQQEEGPKGVDEQSDSSEESEEEKPPEEDKEEEEEKKAPTP 332
+SS + +S + + +S +S ++ + + +
Sbjct: 894 SSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNS 953
Query: 333 QEKKRRKDSSEESDSSEESDIDSEASSALFMAKKKTPPKRERKPSGGSSRGNSRPGTPSA 392
+ DSS SDSS+ + DS SS + + S S+ +S + S+
Sbjct: 954 SDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSS 1013
Query: 393 EGGSTSSTLRAAASKLEQGKRVSEMPAAKRLRLDTGPQSLSGKSTPQPPSGKTTPNS 449
+ ++S + ++ S S + D+ S S S+ S ++ +S
Sbjct: 1014 DSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSS 1070
Score = 55.5 bits (132), Expect = 1e-07
Identities = 41/209 (19%), Positives = 79/209 (37%), Gaps = 4/209 (1%)
Query: 250 KKGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEEPESKAKAPQQEEGPKGVDEQSDSSE 309
+ +D+A +SD+ + Y SD S + +SK E+ +++S+
Sbjct: 470 ESNGNDDANSESDNNSSSRGDASYNSDESKDNGNGSDSKGA----EDDDSDSTSDTNNSD 525
Query: 310 ESEEEKPPEEDKEEEEEKKAPTPQEKKRRKDSSEESDSSEESDIDSEASSALFMAKKKTP 369
+ +D ++ + K + DSS SDSS+ SD DS S++ +
Sbjct: 526 SNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDS 585
Query: 370 PKRERKPSGGSSRGNSRPGTPSAEGGSTSSTLRAAASKLEQGKRVSEMPAAKRLRLDTGP 429
+ S S NS + S++ +S + ++ SK + K S+ + +
Sbjct: 586 DSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDS 645
Query: 430 QSLSGKSTPQPPSGKTTPNSGDVQVTEDA 458
S + NS D + D+
Sbjct: 646 NSSDSSDNSDSSDSSNSSNSSDSSDSSDS 674
Score = 55.1 bits (131), Expect = 2e-07
Identities = 49/283 (17%), Positives = 87/283 (30%), Gaps = 26/283 (9%)
Query: 184 DQDQDEDEEEKEKRGRRKASELRIHDLEDDLEMSSDASDASGEEGGRVPKAKKKAPLAKG 243
D D + + + + D SD+SD+S +
Sbjct: 551 DSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSD---------------- 594
Query: 244 GRKKKKKKGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEEPESKAKAPQQEEGPKGVDE 303
SD DS D D SD S S + +S +K+ + +
Sbjct: 595 --SSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSD 652
Query: 304 QSDSSE--------ESEEEKPPEEDKEEEEEKKAPTPQEKKRRKDSSEESDSSEESDIDS 355
SDSS+ +S + + + + + +SSE SDSS+ SD DS
Sbjct: 653 NSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDS 712
Query: 356 EASSALFMAKKKTPPKRERKPSGGSSRGNSRPGTPSAEGGSTSSTLRAAASKLEQGKRVS 415
SS + S SS + + + S SS +++ +
Sbjct: 713 SDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSD 772
Query: 416 EMPAAKRLRLDTGPQSLSGKSTPQPPSGKTTPNSGDVQVTEDA 458
++ S + + + + NS D + D+
Sbjct: 773 SSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDS 815
Score = 54.7 bits (130), Expect = 2e-07
Identities = 52/286 (18%), Positives = 89/286 (31%), Gaps = 17/286 (5%)
Query: 184 DQDQDEDEEEKEKRGRRKASELRIHDLEDDLEMSSDASDASGEEGGRVPKAKKKAPLAKG 243
D D D + S+ + SSD+SD+S + +
Sbjct: 635 DSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSD 694
Query: 244 GRKKKKKKGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEEPESKAKAPQQEEGPKGVDE 303
+ S D + DS D SD S+SS S + +
Sbjct: 695 SSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSD 754
Query: 304 QSDSSE-----------ESEEEKPPEEDKEEEEEKKAPTPQEKKRRKDSSEESDSSEESD 352
SDSS+ +S + + + + + DSS SDSS+ SD
Sbjct: 755 SSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSD 814
Query: 353 IDSEASSALFMAKKKTPPKRERKPSGGSSRGNSRPGTPSAEGGSTSSTLRAAASKLEQGK 412
SS + S S+ +S + S++G + S+ R+ +S
Sbjct: 815 SSDSDSS------NSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSS 868
Query: 413 RVSEMPAAKRLRLDTGPQSLSGKSTPQPPSGKTTPNSGDVQVTEDA 458
S+ + + S S S + +S D + D+
Sbjct: 869 DSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDS 914
Score = 54.7 bits (130), Expect = 2e-07
Identities = 55/293 (18%), Positives = 97/293 (33%), Gaps = 19/293 (6%)
Query: 184 DQDQDEDEEEKEKRGRRKASELRIHDLEDDLEMSSDASDASGEEGGRVPKAKKKAPLAKG 243
D D + +S+ D SSD+SD S + + + +
Sbjct: 811 DSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDS 870
Query: 244 GRKKKKKKGSD----------DEAFEDSDDGDFEGQEVDYMSDGSSSSQEEPESKAKAPQ 293
SD ++ + S+ D + + SD S SS S++
Sbjct: 871 SDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSS 930
Query: 294 QEEGPKGVDEQSDSSEESEEEKPPE-------EDKEEEEEKKAPTPQEKKRRKDSSEESD 346
SDSS+ S+ + + + + + + DSS+ SD
Sbjct: 931 DNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSD 990
Query: 347 SSEESD-IDSEASSALFMAKKKTPPKRERKPSGGSSRGNSRPGTPSAEGGSTSSTLRAAA 405
SS+ SD DS SS + + S S NS + S++ +S + ++
Sbjct: 991 SSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSD 1050
Query: 406 SKLEQGKRVSEMPAAKRLRLDTGPQSLSGKSTPQPPSGKTTPNSGDVQVTEDA 458
S S + D+ S S S+ S ++ NS D + D+
Sbjct: 1051 SSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSS-NSSDSSDSSDS 1102
Score = 53.9 bits (128), Expect = 3e-07
Identities = 42/228 (18%), Positives = 75/228 (32%), Gaps = 18/228 (7%)
Query: 186 DQDEDEEEKEKRGRRKASELRIHDLEDDLEMSSDASDASGEEGGRVPKAKKKAPLAKGGR 245
D + + +S+ D SSD+SD+S + + +
Sbjct: 775 DSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSD 834
Query: 246 KKKKKKGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEEPESKAKAPQQEEGPKGVDEQS 305
SD D D D + SD S+SS S + +E S
Sbjct: 835 SSNSSDSSDSSDSSDGSDSDSSNR-----SDSSNSSDSSDSSDSSNSSDSSDSSDSNESS 889
Query: 306 DSSEESEEEKPPEEDKEE-------------EEEKKAPTPQEKKRRKDSSEESDSSEESD 352
+SS+ S+ + D + + ++ + DSS SDSS+ SD
Sbjct: 890 NSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSD 949
Query: 353 IDSEASSALFMAKKKTPPKRERKPSGGSSRGNSRPGTPSAEGGSTSST 400
+ + S+ + + S S NS + S++ +S +
Sbjct: 950 SSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDS 997
Score = 53.1 bits (126), Expect = 6e-07
Identities = 48/247 (19%), Positives = 91/247 (36%), Gaps = 10/247 (4%)
Query: 211 EDDLEMSSDASDA-SGEEGGRVPKAKKKAPLAKGGRKKKKKKGSDDEAFEDSDDG-DFEG 268
+DD + +SD +++ S G K+ KG SD DS D D +
Sbjct: 512 DDDSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDS 571
Query: 269 QEVDYMSDGSSSSQEEPESKAKAPQQEEGPKGVDEQSDSSEESEEEKPPEEDKEEEEEKK 328
+ + SD SS + +S + SDSS+ S+ + + + +
Sbjct: 572 SDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSES 631
Query: 329 APTPQEKK------RRKDSSEESDSSEESDIDSEASSALFMAKKKTPPKRERKPSGGSSR 382
+ + K DSS+ SDSS+ S+ + + S+ + + S S
Sbjct: 632 DSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSS--DSSDSSDSSSSSDSSNSSDS 689
Query: 383 GNSRPGTPSAEGGSTSSTLRAAASKLEQGKRVSEMPAAKRLRLDTGPQSLSGKSTPQPPS 442
+S + S+E +S + + +S + + D+ S S S+ S
Sbjct: 690 SDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDS 749
Query: 443 GKTTPNS 449
++ +S
Sbjct: 750 SNSSDSS 756
Score = 53.1 bits (126), Expect = 6e-07
Identities = 44/266 (16%), Positives = 87/266 (32%), Gaps = 2/266 (0%)
Query: 186 DQDEDEEEKEKRGRRKASELRIHDLEDDLEMSSDASDASGEEGGRVPKAKKKAPLAKGGR 245
D + + + +S+ D SSD+SD+S ++ +
Sbjct: 1032 DSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSS 1091
Query: 246 KKKKKKGSDD--EAFEDSDDGDFEGQEVDYMSDGSSSSQEEPESKAKAPQQEEGPKGVDE 303
S D ++ + SD D S SS S + +S + +
Sbjct: 1092 NSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESS 1151
Query: 304 QSDSSEESEEEKPPEEDKEEEEEKKAPTPQEKKRRKDSSEESDSSEESDIDSEASSALFM 363
S S +S + + + + + + DSS+ SDSS+ SD + S+
Sbjct: 1152 DSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSS 1211
Query: 364 AKKKTPPKRERKPSGGSSRGNSRPGTPSAEGGSTSSTLRAAASKLEQGKRVSEMPAAKRL 423
+ + S SS N + + S SS ++ + S+
Sbjct: 1212 DSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDS 1271
Query: 424 RLDTGPQSLSGKSTPQPPSGKTTPNS 449
+ +G + +G + G + +S
Sbjct: 1272 QSKSGNGNNNGSDSDSDSEGSDSNHS 1297
Score = 51.2 bits (121), Expect = 2e-06
Identities = 48/245 (19%), Positives = 83/245 (33%), Gaps = 8/245 (3%)
Query: 213 DLEMSSDASDASGEEGGRVPKAKKKAPLAKGGRKKKKKKGSDDEAFEDSDDGDFEGQEVD 272
D SSD+SD++ + + + + S+ DS D D
Sbjct: 961 DSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSD 1020
Query: 273 YM-SDGSSSSQEEPESKAKAPQQEEGPKGVDEQSDSSEESEEEKPPEEDKEEEEEKKAPT 331
S SS+S + +S + + S +S +S + + + + +
Sbjct: 1021 SSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSD 1080
Query: 332 PQEKKRRKDSSEESDSSEESD-------IDSEASSALFMAKKKTPPKRERKPSGGSSRGN 384
E DSS SDSS+ SD DS SS + + S S N
Sbjct: 1081 SSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSN 1140
Query: 385 SRPGTPSAEGGSTSSTLRAAASKLEQGKRVSEMPAAKRLRLDTGPQSLSGKSTPQPPSGK 444
S + S+E +S + ++ S S + D+ S S S+ S
Sbjct: 1141 SSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSD 1200
Query: 445 TTPNS 449
++ +S
Sbjct: 1201 SSDSS 1205
Score = 50.1 bits (118), Expect = 5e-06
Identities = 47/267 (17%), Positives = 81/267 (30%), Gaps = 6/267 (2%)
Query: 184 DQDQDEDEEEKEKRGRRKASELRIHDLEDDLEMSSDASDASGE-EGGRVPKAKKKAPLAK 242
D D E S D SSD+SD+S + + + +
Sbjct: 878 DSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSD 937
Query: 243 GGRKKKKKKGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEEPESKAKAPQQEEGPKGVD 302
SD DS + D SS S + S + +
Sbjct: 938 SSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDS 997
Query: 303 EQSDSSEESEEEKPPEEDKEEEEEKKAPTPQEKKRRKDSSEESDSSEESDIDSEASSALF 362
S +S +S + + + + DSS+ SDSS+ SD + S+
Sbjct: 998 SDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSS-- 1055
Query: 363 MAKKKTPPKRERKPSGGSSRGNSRPGTPSAEGGSTSSTLRAAASKLEQGKRVSEMPAAKR 422
+ S S +S + S+E +S + ++ S S +
Sbjct: 1056 ---NSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSS 1112
Query: 423 LRLDTGPQSLSGKSTPQPPSGKTTPNS 449
D+ S S S+ S ++ +S
Sbjct: 1113 DSSDSSDSSNSSDSSDSSDSSDSSDSS 1139
Score = 50.1 bits (118), Expect = 5e-06
Identities = 49/276 (17%), Positives = 89/276 (32%), Gaps = 2/276 (0%)
Query: 184 DQDQDEDEEEKEKRGRRKASELRIHDLEDDLEMSSDASDASGEEGGRVPKAKKKAPLAKG 243
D D + +S D SSD+SD+S + +
Sbjct: 961 DSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSD 1020
Query: 244 GRKKKKKKGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEEPESKAKAPQQEEGPKGVDE 303
S D + + SD D S SS+S + +S + +
Sbjct: 1021 SSNSSDSSNSSDSS-DSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSS 1079
Query: 304 QSDSSEESEEEKPPEEDKEEEEEKKAPTPQEKKRRKDSSEESDSSEESD-IDSEASSALF 362
S S +S + + + + + + DSS+ S+SS+ SD DS SS
Sbjct: 1080 DSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSS 1139
Query: 363 MAKKKTPPKRERKPSGGSSRGNSRPGTPSAEGGSTSSTLRAAASKLEQGKRVSEMPAAKR 422
+ + S S +S + S++ +S + ++ S S +
Sbjct: 1140 NSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSS 1199
Query: 423 LRLDTGPQSLSGKSTPQPPSGKTTPNSGDVQVTEDA 458
D+ S S S+ S ++ +S E +
Sbjct: 1200 DSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESS 1235
Score = 49.3 bits (116), Expect = 8e-06
Identities = 46/259 (17%), Positives = 94/259 (36%), Gaps = 11/259 (4%)
Query: 190 DEEEKEKRGRRKASELRIHDLEDDLEMSSDASDASGEEGGRVPKAKKKAPLAKGGRKKKK 249
D ++K +G S + +D S + S + G+ ++K G K
Sbjct: 454 DFDDKSMQGDDPNSSDESNGNDDANSESDNNSSSRGDASYNSDESKDNG----NGSDSKG 509
Query: 250 KKGSDDEAFEDSDDGDFEGQ------EVDYMSDGSSSSQEEPESKAKAPQQEEGPKGVDE 303
+ D ++ D+++ D G + D G S + + + D
Sbjct: 510 AEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDS 569
Query: 304 QSDSSEESEEEKPPEEDKEEEEEKKAPTPQEKKRRKDSSEESDSSEESDIDSEASSALFM 363
S S S + + D + + + DSS+ SDSS+ SD S++ S
Sbjct: 570 DSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSD-SSDSKSDSSK 628
Query: 364 AKKKTPPKRERKPSGGSSRGNSRPGTPSAEGGSTSSTLRAAASKLEQGKRVSEMPAAKRL 423
++ + + S S+ +S + S++ ++S++ ++ S S +
Sbjct: 629 SESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSD 688
Query: 424 RLDTGPQSLSGKSTPQPPS 442
D+ S S +S+ S
Sbjct: 689 SSDSSDSSNSSESSDSSDS 707
Score = 48.1 bits (113), Expect = 2e-05
Identities = 39/273 (14%), Positives = 81/273 (29%)
Query: 186 DQDEDEEEKEKRGRRKASELRIHDLEDDLEMSSDASDASGEEGGRVPKAKKKAPLAKGGR 245
D + + +S+ ++ SSD+SD+S + + +
Sbjct: 860 DSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSN 919
Query: 246 KKKKKKGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEEPESKAKAPQQEEGPKGVDEQS 305
+ S+ +S D D +SS + + + S
Sbjct: 920 SSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDS 979
Query: 306 DSSEESEEEKPPEEDKEEEEEKKAPTPQEKKRRKDSSEESDSSEESDIDSEASSALFMAK 365
+S +S + + + + + + DSS SDSS SD + + S+
Sbjct: 980 SNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDS 1039
Query: 366 KKTPPKRERKPSGGSSRGNSRPGTPSAEGGSTSSTLRAAASKLEQGKRVSEMPAAKRLRL 425
+ + S SS + + + S SS ++ E ++
Sbjct: 1040 SDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDS 1099
Query: 426 DTGPQSLSGKSTPQPPSGKTTPNSGDVQVTEDA 458
S + + NS D + D+
Sbjct: 1100 SDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDS 1132
Score = 32.3 bits (72), Expect = 1.1
Identities = 37/184 (20%), Positives = 76/184 (41%), Gaps = 16/184 (8%)
Query: 184 DQDQDEDEEEKEKRGRRKASELRIHDLEDDLEMSSDASDASGEEGGRVPKAK----KKAP 239
D +ED ++ G + A D ED++ +S ++ + E +K K+A
Sbjct: 169 DAGHNEDVAVVQEDGPQVAGSNNSTDNEDEIIENSCRNEGNTSEITPQINSKRNGTKEAE 228
Query: 240 LAKG-----GRKKKKKKGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEEPESKAKAPQQ 294
+ G G S + A ED D+G + ++ + + SS+ + + ++
Sbjct: 229 VTPGTGEDAGLDNSDGSPSGNGADEDEDEGSGDDEDEEAGNGKDSSNNSKGQEGQDHGKE 288
Query: 295 EEGPKGVDEQSDSSE----ESEEEKPPEEDKE---EEEEKKAPTPQEKKRRKDSSEESDS 347
++ + + SDS E E +E+ E D + + EE A P++ ++ + +
Sbjct: 289 DDHDSSIGQNSDSKEYYDPEGKEDPHNEVDGDKTSKSEENSAGIPEDNGSQRIEDTQKLN 348
Query: 348 SEES 351
ES
Sbjct: 349 HRES 352
Score = 31.2 bits (69), Expect = 2.4
Identities = 30/147 (20%), Positives = 60/147 (40%), Gaps = 6/147 (4%)
Query: 244 GRKKKKKKGSDDEAFEDSDDG-----DFEGQE-VDYMSDGSSSSQEEPESKAKAPQQEEG 297
G + + +GS D+ E++ +G + +GQE D+ + S S +K EG
Sbjct: 250 GADEDEDEGSGDDEDEEAGNGKDSSNNSKGQEGQDHGKEDDHDSSIGQNSDSKEYYDPEG 309
Query: 298 PKGVDEQSDSSEESEEEKPPEEDKEEEEEKKAPTPQEKKRRKDSSEESDSSEESDIDSEA 357
+ + D + S+ E+ E+ ++ Q+ R+ E+ ++ES+ +
Sbjct: 310 KEDPHNEVDGDKTSKSEENSAGIPEDNGSQRIEDTQKLNHRESKRVENRITKESETHAVG 369
Query: 358 SSALFMAKKKTPPKRERKPSGGSSRGN 384
S + K P R + +GN
Sbjct: 370 KSQDKGIEIKGPSSGNRNITKEVGKGN 396
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 60.8 bits (146), Expect = 3e-09
Identities = 59/268 (22%), Positives = 120/268 (44%), Gaps = 23/268 (8%)
Query: 153 RTLTAEEAEE-EWERRNKVLNHFSIMQQRRLKDQDQDEDEEEKEKRGRRKASELRIHDLE 211
+T+ ++AE+ E ER+ + + + + ++ + + ++ K+K +RK E ++
Sbjct: 226 KTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEE---ETVK 282
Query: 212 DDLEMSSDASDASGEEGGRVPKAKKKAPLAKGGRKKKKKKGSDDEAFEDSDDGDFEGQEV 271
+ + + AS E+ A+ K + KKKKKG +E ++ G
Sbjct: 283 SKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKG------- 335
Query: 272 DYMSDGSSSSQEEPESKAKAPQQEEGPKGVDEQSDSSEESEEEKPPEEDKEEEEEKKAPT 331
++ + E+ AK ++EE K +E+ E E K EE++ E+E+++
Sbjct: 336 ----PSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKK 391
Query: 332 PQEKKRRKDSSEE----SDSSEESDIDSEASSALFMAKKKTPPKRE----RKPSGGSSRG 383
+EK+R++ +E + S E+ +EA+ L A+ P ++ ++P +
Sbjct: 392 QKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKR 451
Query: 384 NSRPGTPSAEGGSTSSTLRAAASKLEQG 411
P ++ S S L AA +EQG
Sbjct: 452 KKIPQQLESKEVSESMELCAAVEVMEQG 479
Score = 57.4 bits (137), Expect = 3e-08
Identities = 72/351 (20%), Positives = 139/351 (39%), Gaps = 61/351 (17%)
Query: 189 EDEEEKEKRGRRKASELRIHDLEDDL--EMSSDASDASGEEGGRV-----PKAKKKAPLA 241
+++E ++ +G++K + + EDD+ E+ + +A G + R P +
Sbjct: 33 KEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPTENNEEEFT 92
Query: 242 KGGRKKKKKKGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEEPESKAKAPQQEEGPKGV 301
+KKK +KG ++F+D+D + E ++ +SK A + E G
Sbjct: 93 SKDKKKKGQKGKK-QSFDDNDSEELE--------------DKDSKSKKTAKPKVEMYSGS 137
Query: 302 DEQSDSSEESEEEKPPEE------DKEEEEEKKAPTPQEKKRRKDSSEESDSSEESDIDS 355
D+ D ++ ++ K + D EE+E + +E+ R S E D S+E
Sbjct: 138 DDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDE----- 192
Query: 356 EASSALFMAKKKTPPKRERKPSGGSSRGNSRPGTPSAEGGSTSSTLRAAASKLEQGKRVS 415
F+ +K K ++ G + + S + T + +A + E+ KR
Sbjct: 193 ------FLQSRKGQKKNQKNKPGPNIESGNEDDDASFK-IKTVAQKKAEKKERERKKRDE 245
Query: 416 EMPAAKRLR----LDTGPQSLSGKSTPQ------PPSGKTTPNSGDVQVTEDAVRRYLTR 465
E ++L+ L+TG + S + Q K T ++G + +E+
Sbjct: 246 EKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAA 305
Query: 466 KPMTTKDLLKKFQTKKTGLSSEQ-----------TVNVLAQILKRLNPERK 505
+ D KK + KK G E+ TV + + L +L E +
Sbjct: 306 EDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEE 356
Score = 53.9 bits (128), Expect = 3e-07
Identities = 67/353 (18%), Positives = 139/353 (39%), Gaps = 36/353 (10%)
Query: 145 NFTPLARHRTLTAEEAEEEWERRNKVL-NHFSIMQQRRLKDQDQDEDEEEKEKRGRRKAS 203
+F L + A+++ ++W+ + N I ++ R+ + DE ++ + R+
Sbjct: 142 DFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQK 201
Query: 204 ELRIHDLEDDLEMSSDASDAS------------GEEGGRVPKAKKKAPLAKGGRKKKKKK 251
+ + + ++E ++ DAS +E R + ++KA L K K++ +
Sbjct: 202 KNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELET 261
Query: 252 GSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEEPESKAKAPQQEEGPKGVDEQSDSSEES 311
G D++ + FE + V + E KA+ P E D + D ++
Sbjct: 262 GKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAED----DNEGDKKKKD 317
Query: 312 EEEKPPEEDKEEEEEKKAPTPQEKK-------RRKDSSEESDSSEESDID--SEASSALF 362
+++K E++++E+E+KK P+ K + K+ E EE I E +
Sbjct: 318 KKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRK 377
Query: 363 MAKKKTPPKRERKPSGGSSRGNSRPGTPSAEGGSTSSTLRAAASKLEQGKRVSEMPAAKR 422
++ KRERK + R EG + + R A ++ E ++ + +
Sbjct: 378 EEERLEQEKRERK----KQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEV 433
Query: 423 LRLDTGP------QSLSGKSTPQPPSGKTTPNSGDVQVTEDAVRRYLTRKPMT 469
D+ P + K PQ K S ++ + + + + K T
Sbjct: 434 PSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEET 486
Score = 49.7 bits (117), Expect = 6e-06
Identities = 83/397 (20%), Positives = 147/397 (37%), Gaps = 80/397 (20%)
Query: 46 RLERDLSNKKIYQEEEMPESGAGS-------EFNRKLREEARRKKY----GIVLKEFRPE 94
R +RD K+ + +E E G E RK EE + K G++
Sbjct: 240 RKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKA 299
Query: 95 DQPWLLRVNGKSGRKFKGIKKGGVTENTSYYIFTQCPDGAFEAFPVHNWYNFTPLARHRT 154
+ P + + +K K KK + + P A T A
Sbjct: 300 ETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKA------------TVKAMQEA 347
Query: 155 LTAEEAEEEWERRNKVLNHFSIMQQRRLKDQDQDEDEEEKEKRGRRKASELRIHDLEDDL 214
L + EEE ++R + +++ K ++++ E+EK +R ++K E + ++
Sbjct: 348 LAKLKEEEERQKREEE-ERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGK 406
Query: 215 EMSSDASDASGE----------EGGRVPKAK---KKAPLAKGGRKKK------KKKGSDD 255
++ +A +G VP KK P+ + ++KK K+ S+
Sbjct: 407 LLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSES 466
Query: 256 --------------------------EAFEDSDDG---DFEGQEVDYMSDGSSSSQEEPE 286
E ED++D D+E D ++ ++ E
Sbjct: 467 MELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIE 526
Query: 287 SKAKAPQQEEGPKGVDEQSDSSEESEEE------KPPEEDKEEEEEKKAPTPQEKKRRKD 340
K ++EE + +E +S EE EEE + EED++ +EK + +KK K+
Sbjct: 527 VKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKE 586
Query: 341 SSEESDSSEESDIDSEASSALFMAKKKTPPKRERKPS 377
S SDS +SD D + K+ KR + S
Sbjct: 587 MS--SDSEYDSDDDRTKEERAYDKAKRRIEKRRLEHS 621
Score = 46.2 bits (108), Expect = 7e-05
Identities = 37/141 (26%), Positives = 65/141 (46%), Gaps = 26/141 (18%)
Query: 248 KKKKGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEEPESKAKAPQQEEGPKGVDEQSDS 307
KK+K +++ +D D D E+ +G+ +++E+ K+K +++E K ++ D
Sbjct: 3 KKQKNKSEDSTKDDIDLDALAAEI----EGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDI 58
Query: 308 SEESEE---------------EKPPEEDKEEEEEKKAPTPQEKKRRKDSSEESDSSEESD 352
+E EE P E+ EEE K + +K +K S +++DS E D
Sbjct: 59 LKELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELED 118
Query: 353 IDSEASSALFMAKKKTPPKRE 373
DS+ +KK PK E
Sbjct: 119 KDSK-------SKKTAKPKVE 132
>gi|20270337 Leo1, Paf1/RNA polymerase II complex component, homolog
[Homo sapiens]
Length = 666
Score = 60.8 bits (146), Expect = 3e-09
Identities = 52/244 (21%), Positives = 97/244 (39%), Gaps = 13/244 (5%)
Query: 157 AEEAEEEWERRNKVLNHFSIMQQRRLKDQDQDEDEEEKEKRGRRKASEL----RIHDLED 212
++ E ER + N S + Q + D+++E G SE + H +D
Sbjct: 84 SDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGSHHSEAEGSEKAHS-DD 142
Query: 213 DLEMSSDASDASGEEGGRVPKAKKKAPLAKGGRKKKKKKGSDDEAFEDSDDGDFEGQEVD 272
+ D SD S +E + +++A +G + K + DDE +++DD +E
Sbjct: 143 EKWGREDKSDQSDDEKIQNSDDEERA---QGSDEDKLQNSDDDEKMQNTDD-----EERP 194
Query: 273 YMSDGSSSSQEEPESKAKAPQQEEGPKGVDEQSDSSEESEEEKPPEEDKEEEEEKKAPTP 332
+SD E E ++ DE+ +S +E + + EE + ++++
Sbjct: 195 QLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQAS 254
Query: 333 QEKKRRKDSSEESDSSEESDIDSEASSALFMAKKKTPPKRERKPSGGSSRGNSRPGTPSA 392
E+ R D EE D ES S++ + K+K + + + GT
Sbjct: 255 DEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDTEVPKDNSGTMDL 314
Query: 393 EGGS 396
GG+
Sbjct: 315 FGGA 318
Score = 45.8 bits (107), Expect = 9e-05
Identities = 39/184 (21%), Positives = 70/184 (38%), Gaps = 19/184 (10%)
Query: 182 LKDQDQDEDEEEKEKRGRRKASELRIHDLEDDLEMSSDASDASGEEGGRVPKAKKKAPLA 241
++D + + E E++ S D + D E ++ S+ASG E + + P
Sbjct: 4 MEDLFGSDADSEAERKDSDSGS-----DSDSDQENAASGSNASGSESDQDERGDSGQP-- 56
Query: 242 KGGRKKKKKKGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEEPE----------SKAKA 291
K+ S+DE D + D S+ S S E S+A
Sbjct: 57 --SNKELFGDDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPN 114
Query: 292 PQQEEGPKGVDEQSDSSEESEEEKPPEEDKEEEEEKKAPTPQEKKRRKDSSEESDSSEES 351
++EG + S E E+ +++K E+K + EK + D E + S+E
Sbjct: 115 DDEDEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDED 174
Query: 352 DIDS 355
+ +
Sbjct: 175 KLQN 178
Score = 33.5 bits (75), Expect = 0.48
Identities = 24/104 (23%), Positives = 37/104 (35%), Gaps = 11/104 (10%)
Query: 263 DGDFEGQEVDYMSDGSSSSQEEPESKAKAPQQEEGPKGVDEQSDSSE---------ESEE 313
D D E + D SD S S + E+ A DE+ DS + +SE+
Sbjct: 11 DADSEAERKD--SDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSED 68
Query: 314 EKPPEEDKEEEEEKKAPTPQEKKRRKDSSEESDSSEESDIDSEA 357
E + +++ E R D + S + SEA
Sbjct: 69 EGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEA 112
Score = 32.7 bits (73), Expect = 0.82
Identities = 34/126 (26%), Positives = 46/126 (36%), Gaps = 20/126 (15%)
Query: 155 LTAEEAEEEWERRNKVLNHFSIMQQRRLKDQDQDEDEEEKEK----------RGRRKASE 204
L A E +RR + H + L+ DE+EE +E +G +
Sbjct: 543 LRASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESISLAAIKNRYKGGIREER 602
Query: 205 LRIHDLEDDLEMSSDASD--------ASGEEGGRVPKAKKKAPLAKGGRKKKKKKGSDDE 256
RI+ + D D + S EEG P K+KA KK KK DE
Sbjct: 603 ARIYSSDSDEGSEEDKAQRLLKAKKLTSDEEGE--PSGKRKAEDDDKANKKHKKYVISDE 660
Query: 257 AFEDSD 262
ED D
Sbjct: 661 EEEDDD 666
Score = 31.6 bits (70), Expect = 1.8
Identities = 34/152 (22%), Positives = 56/152 (36%), Gaps = 47/152 (30%)
Query: 249 KKKGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEE--------------PESKAKAPQQ 294
++K SD + DSD E + GS S Q+E +S+ +
Sbjct: 17 ERKDSDSGSDSDSDQ---ENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEGASH 73
Query: 295 EEGPKGVDEQSDSSEESEE-----------------EKPPEEDKEE-------------E 324
G E+SD+ E+ E + P +D++E E
Sbjct: 74 HSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGSHHSEAE 133
Query: 325 EEKKAPTPQEKKRRKDSSEESDSSEESDIDSE 356
+KA + EK R+D S++SD + + D E
Sbjct: 134 GSEKAHSDDEKWGREDKSDQSDDEKIQNSDDE 165
Score = 31.6 bits (70), Expect = 1.8
Identities = 27/101 (26%), Positives = 43/101 (42%), Gaps = 4/101 (3%)
Query: 282 QEEPESKAKAPQQEEGPKGVDEQSDSSEESEEEKPPEEDKEEEEEKKAPTPQEKKRRKDS 341
+EE +A ++ + + ++Q + +P D+EEE E+ K R K
Sbjct: 538 KEEERLRASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESISLAAIKNRYKGG 597
Query: 342 SEESDS---SEESDIDSEASSALFMAK-KKTPPKRERKPSG 378
E + S +SD SE A + K KK E +PSG
Sbjct: 598 IREERARIYSSDSDEGSEEDKAQRLLKAKKLTSDEEGEPSG 638
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 60.5 bits (145), Expect = 4e-09
Identities = 60/223 (26%), Positives = 109/223 (48%), Gaps = 31/223 (13%)
Query: 151 RHRTLTAEEAE---EEW---ERRNKVLNHFSIM--QQRRLKDQ-----DQDEDEEEKEKR 197
+ R L+ E+++ +EW E+R+++ + +QR+L ++ +++E E+E +
Sbjct: 2107 KERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESK 2166
Query: 198 GRRKASELRIHDLEDDLEMSSDASDASGEEGGRVPKAKK---KAPLAKGGRKKKKKKGSD 254
RK SE+ + D E+ EE +P K+ K AK G K K+K S
Sbjct: 2167 LARKHSEVILDDEEE----------GGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQ 2216
Query: 255 DEAFEDSDDGDFEGQEV-DYMSDGSSSSQEEPESKAKAPQQEEGPKGVDEQSDSSEESEE 313
+ E + E + + D + S S EE E + + ++EE +E+ EE E
Sbjct: 2217 VDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGE 2276
Query: 314 EKPPEEDKEEEEEKKAPTPQEKKRRKDSSEESDSSEESDIDSE 356
EK E+++EE+++KK +EKK+ + +E E+ +I SE
Sbjct: 2277 EKQVEKEEEEKKKKK----KEKKKEEVQEKEEVFEEKEEIMSE 2315
Score = 50.4 bits (119), Expect = 4e-06
Identities = 50/207 (24%), Positives = 98/207 (47%), Gaps = 10/207 (4%)
Query: 178 QQRRLKDQDQDEDEEEKE-KRGRRKASELRIHDLEDDLEMSSDASDASGEEGGRVPKAKK 236
++R+L +++ +EE++ + RK ++ + +DD EM+ + +E + +K
Sbjct: 1591 EERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEK 1650
Query: 237 KAPLAKGGRKKKKK--KGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEEPESKAKAP-Q 293
+ A+ +K+KK K + A E+ G+ + + + +E P+ + Q
Sbjct: 1651 LSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQ 1710
Query: 294 QEEGPKGVDEQSDSSEE---SEEEKPPEEDKEEEEEKKAPTPQEK---KRRKDSSEESDS 347
++E + ++E EE EEE EE K EE+KK +E +R K S EE+
Sbjct: 1711 EKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKL 1770
Query: 348 SEESDIDSEASSALFMAKKKTPPKRER 374
++E ++ + L K+K P + ER
Sbjct: 1771 AQEEELLIQEKEKLAQHKEKMPEEEER 1797
Score = 38.9 bits (89), Expect = 0.011
Identities = 71/297 (23%), Positives = 120/297 (40%), Gaps = 77/297 (25%)
Query: 45 ARLERDLSNKK---IYQEEEMPESGAGSEFNRKLREEAR--RKKYGIVLKEFRPE-DQPW 98
AR +R L+NK I +EE+M E S+ RK E ++ GI +E P + W
Sbjct: 2140 ARKQRKLANKMRRMINKEEKMTEEE--SKLARKHSEVILDDEEEGGIEEEEVIPFLKRRW 2197
Query: 99 LLRVNGKSGRKFKGIKKGGVTENTSYYIFTQCPDGAFEAFPVHNWYNFTPLARHRTLTAE 158
R K G K K V E S F++ + + L + +L++E
Sbjct: 2198 RKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDE-----------LEKQESLSSE 2246
Query: 159 EAEEEWERRNKVLNHFSIMQQRRLKDQDQDEDEEEKEKRGRRKASELRIHDLEDDLEMSS 218
E EE E ++ R +++ ++E+EE KE
Sbjct: 2247 EEEEREE------------EEEREEEEVREEEEERKE----------------------- 2271
Query: 219 DASDASGEEGGRVPKAKKKAPLAKGGRKKKKKKGSDDEAFEDSDDGDFEGQEVDYMSDGS 278
EE G + +K+ KKKKKK E ++ ++ E +E+
Sbjct: 2272 -------EEEGEEKQVEKEEE-----EKKKKKKEKKKEEVQEKEEVFEEKEEI------- 2312
Query: 279 SSSQEEPESKAKAPQQEEGPKGVDEQSDSSEESEEEKPPEEDKEEEEEKKAPTPQEK 335
S+EE ES + ++EE ++E+ D E E K ++ K +E+ +K+ +E+
Sbjct: 2313 -MSEEETESLSDEEEEEES-CSLEEEVD--REKEILKKEKQFKLQEQRRKSLRGRER 2365
Score = 33.5 bits (75), Expect = 0.48
Identities = 49/201 (24%), Positives = 86/201 (42%), Gaps = 45/201 (22%)
Query: 149 LARHRTLTAEEAEEEWERRNKVLNHFSIMQQR--RLKDQDQDEDEEEKEKRGRRKASELR 206
LA+ A E E+ ++ K+ +I+ Q+ L ++Q+ D +EKE A EL
Sbjct: 1665 LAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKEL-----AQELE 1719
Query: 207 IHDLEDDLEMSSDASDASGEEGGRVPKAKKKAPLAKGGRKKKKKKGSDDEAFEDSDDGDF 266
+LE D+E S + +E G++ + KKK + +++K S++E
Sbjct: 1720 --ELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEE---------- 1767
Query: 267 EGQEVDYMSDGSSSSQEEP---ESKAKAPQQEEGPKGVDEQSDSSEESEEEKPPEEDKEE 323
+ +QEE + K K Q +E + EEE+ +E+
Sbjct: 1768 -----------TKLAQEEELLIQEKEKLAQHKE------------KMPEEEERLGRKREQ 1804
Query: 324 EEEKKAPTPQEKKRRKDSSEE 344
EKK Q+++R +S EE
Sbjct: 1805 LIEKKMKLAQKRERWINSMEE 1825
>gi|55741677 SET domain containing 1A [Homo sapiens]
Length = 1707
Score = 60.1 bits (144), Expect = 5e-09
Identities = 53/198 (26%), Positives = 77/198 (38%), Gaps = 14/198 (7%)
Query: 180 RRLKDQDQDEDEEEKEKRGRRKASELRIHDLEDDLEMSSDASDASGEEGGRVPKAKKKAP 239
+R + + E EEK R A E EDD E +A + G G + PK ++
Sbjct: 896 KRKEPSEISEASEEKRPRPSTPAEED-----EDDPEQEKEAGEP-GRPGTKPPKRDEERG 949
Query: 240 LAKGGRKKKKKKGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEEPESKAKAPQQEEGPK 299
+G K +K D E E S + E E D D +EE K ++ E
Sbjct: 950 KTQG--KHRKSFALDSEGEEASQESSSEKDEEDDEEDEEDEDREEAVDTTK--KETEVSD 1005
Query: 300 GVDEQSDSSEE----SEEEKPPEEDKEEEEEKKAPTPQEKKRRKDSSEESDSSEESDIDS 355
G DE+SDSS + ++ + + + E + + SS S SSE S D
Sbjct: 1006 GEDEESDSSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDE 1065
Query: 356 EASSALFMAKKKTPPKRE 373
E +PP RE
Sbjct: 1066 EEEERPAALPSASPPPRE 1083
Score = 56.2 bits (134), Expect = 7e-08
Identities = 56/265 (21%), Positives = 111/265 (41%), Gaps = 16/265 (6%)
Query: 161 EEEWERRNKVLNHFSIMQQRRLKDQDQDEDEEEKEKRGRRKASELRIHDLEDDLEMSSDA 220
++ WE + + F +++ K EE+KEK ++ L + D +
Sbjct: 824 DQWWESKEEKAKPFQNAAKQQAK-------EEDKEKTKLKEPGLLSLVDWAKSGGTTGIE 876
Query: 221 SDA--SGEEGG-RVP--KAKKKAPLAKGGRKKKKKKGSDDEAFEDSDDGDFEGQEVDYMS 275
+ A SG G R+P K K+K P ++K+ A ED DD + QE +
Sbjct: 877 AFAFGSGLRGALRLPSFKVKRKEPSEISEASEEKRPRPSTPAEEDEDDPE---QEKEAGE 933
Query: 276 DGSSSSQEEPESKAKAPQQEEGPKGVDEQSDSSEESEEEKPPEEDKEEEEEKKAPTPQEK 335
G ++ + + Q + K S+ E S+E ++++++EE+++ +E
Sbjct: 934 PGRPGTKPPKRDEERGKTQGKHRKSFALDSEGEEASQESSSEKDEEDDEEDEEDEDREEA 993
Query: 336 KRRKDSSEESDSSEESDIDSEASSALFMAKKKTPPKRERKPSGGSSRGNSRPGTPSAEGG 395
E E+ + DS + +L+ S SS +S + S+
Sbjct: 994 VDTTKKETEVSDGEDEESDSSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSSSS 1053
Query: 396 STSSTLRAAASKLEQGKRVSEMPAA 420
S+SS+ +++ E+ +R + +P+A
Sbjct: 1054 SSSSS-ESSSEDEEEEERPAALPSA 1077
Score = 44.3 bits (103), Expect = 3e-04
Identities = 52/243 (21%), Positives = 82/243 (33%), Gaps = 43/243 (17%)
Query: 184 DQDQDEDEEEKE----------------KRGRRKASELRIHDLEDDLEMSS--------- 218
++D+D+ E+EKE +RG+ + + L+ + E +S
Sbjct: 919 EEDEDDPEQEKEAGEPGRPGTKPPKRDEERGKTQGKHRKSFALDSEGEEASQESSSEKDE 978
Query: 219 --DASDASGEEGGRVPKAKKKAPLAKGGRKKKKKKGSDDEAFEDSDDGDFEGQEVDYMSD 276
D D E+ KK G ++ S + DSD E D SD
Sbjct: 979 EDDEEDEEDEDREEAVDTTKKETEVSDGEDEESDSSSKCSLYADSDG------ENDSTSD 1032
Query: 277 GSSSSQEEPESKAKAPQQEEGPKGVDEQSDSSEESEEEKPPEEDKEEEEEKKAPTPQEKK 336
SSS S + + E S S +E EEE+P ++ P P
Sbjct: 1033 SESSSSSSSSSSSSSSSSSSSSSSSSESS-SEDEEEEERPAALPSASPPPREVPVPTPAP 1091
Query: 337 RRKDSSEESDSSEESDI-DSEASSALFMAKKK--------TPPKRERKPSGGSSRGNSRP 387
E S + + + EAS A + PP+ P + R + RP
Sbjct: 1092 VEVPVPERVAGSPVTPLPEQEASPARPAGPTEESPPSAPLRPPEPPAGPPAPAPRPDERP 1151
Query: 388 GTP 390
+P
Sbjct: 1152 SSP 1154
Score = 30.8 bits (68), Expect = 3.1
Identities = 27/130 (20%), Positives = 55/130 (42%), Gaps = 13/130 (10%)
Query: 254 DDEAFEDSDDGDFEGQEVDYM----SDGSSSSQEEPESKAKAPQQEEGPKGV-----DEQ 304
D EA E SD+ + + ++ + + P + P+ P + DE
Sbjct: 1276 DSEATETSDEAERPRPLLSHILLEHNYALAVKPTPPAPALRPPEPVPAPAALFSSPADEV 1335
Query: 305 SDSSE----ESEEEKPPEEDKEEEEEKKAPTPQEKKRRKDSSEESDSSEESDIDSEASSA 360
++ E E+EE KP + ++ EE ++ + ++ ++SS+ S SS+ S
Sbjct: 1336 LEAPEVVVAEAEEPKPQQLQQQREEGEEEGEEEGEEEEEESSDSSSSSDGEGALRRRSLR 1395
Query: 361 LFMAKKKTPP 370
+++ PP
Sbjct: 1396 SHARRRRPPP 1405
>gi|21396500 HIRA interacting protein 3 [Homo sapiens]
Length = 556
Score = 60.1 bits (144), Expect = 5e-09
Identities = 68/307 (22%), Positives = 119/307 (38%), Gaps = 56/307 (18%)
Query: 151 RHRTLTAEEAEEEWERRNKVLNHFSIMQQRRLKDQDQDEDEEEKEKRGRRKASELRIHDL 210
R R L A+ EE E +++ K + + + +K+ G+ S + +
Sbjct: 147 RQRDLPAQRGEESSEE-----------EEKGYKGKTRKKPVVKKQAPGKASVSRKQAREE 195
Query: 211 EDDLEMSSDASDASGEEGGRVPKAKKKAPLAKGGRKKKKKKGSDDEAFEDSDDGDFEGQE 270
++ E A EG + K+ K++ +KK +E E+ + + E ++
Sbjct: 196 SEESEAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQKKEQREEEVEEEEKEEDE-EK 254
Query: 271 VDYMSDGSSSSQEEPESKAKAPQQEEGPKGVDEQSDSSEESEE-----------EKPPEE 319
D+ S+ + + + ++ +Q+ K + SDS EE +E +PP +
Sbjct: 255 GDWKPRTRSNGRRKSAREERSCKQKSQAKRLLGDSDSEEEQKEAASSGDDSGRDREPPVQ 314
Query: 320 DK-----------------EEEEEKKAPTPQEKKRRKDSSEESDSSEESDI-----DSEA 357
K E+EE+ P K RK + S S EESD+ DSEA
Sbjct: 315 RKSEDRTQLKGGKRLSGSSEDEEDSGKGEPTAKGSRKMARLGSTSGEESDLEREVSDSEA 374
Query: 358 SSALFMAKKKTPPKRERKPSGGSSRGNSRPGTPSAEGGSTSSTLRAAASKLEQGKRVSEM 417
+K K+ + S +S G+P A+GG S G+R +
Sbjct: 375 GGGPQGERKNRSSKKSSRKGRTRSSSSSSDGSPEAKGGKAGS-----------GRRGEDH 423
Query: 418 PAAKRLR 424
PA RL+
Sbjct: 424 PAVMRLK 430
Score = 57.8 bits (138), Expect = 2e-08
Identities = 80/307 (26%), Positives = 117/307 (38%), Gaps = 74/307 (24%)
Query: 191 EEEKEKRGRRKASELRIHDLEDDLEMSSDASDASGEEGGRVPKAKKKAPLAKGGRKKKKK 250
+EE +R + E + + DL + EE G K +KK + K + K
Sbjct: 128 KEENPRRASKAVEESSDEERQRDLPAQRGEESSEEEEKGYKGKTRKKPVVKK--QAPGKA 185
Query: 251 KGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEEPESKAKAPQQEEGPKGVDEQSDSSEE 310
S +A E+S++ E E + ++ EG KG +S +E
Sbjct: 186 SVSRKQAREESEES-------------------EAEPVQRTAKKVEGNKGTKSLKESEQE 226
Query: 311 SE-----------EEKPPEEDKEEEEEKK--APTPQEKKRRKDSSEESDSSEES------ 351
SE EE+ EE+KEE+EEK P + RRK + EE ++S
Sbjct: 227 SEEEILAQKKEQREEEVEEEEKEEDEEKGDWKPRTRSNGRRKSAREERSCKQKSQAKRLL 286
Query: 352 -DIDSE------ASSALFMAKKKTPPKRER----------KPSGGSSRG--NSRPGTPSA 392
D DSE ASS + + PP + + K GSS +S G P+A
Sbjct: 287 GDSDSEEEQKEAASSGDDSGRDREPPVQRKSEDRTQLKGGKRLSGSSEDEEDSGKGEPTA 346
Query: 393 EG-------GSTS---STLRAAASKLE-----QGKRVSEMPAAKRLRLDTGPQSLSGKST 437
+G GSTS S L S E QG+R + + T S S +
Sbjct: 347 KGSRKMARLGSTSGEESDLEREVSDSEAGGGPQGERKNRSSKKSSRKGRTRSSSSSSDGS 406
Query: 438 PQPPSGK 444
P+ GK
Sbjct: 407 PEAKGGK 413
Score = 46.2 bits (108), Expect = 7e-05
Identities = 51/199 (25%), Positives = 81/199 (40%), Gaps = 22/199 (11%)
Query: 175 SIMQQRRLKDQDQDEDEEEKEKRGRRKASELRIHDLEDDLEMSSDASDASGEEGGRVPKA 234
SI+++R L + E E EK+ ++ E E+ L+M D + AS E+ + K
Sbjct: 27 SIVRRRYLAHSGRSHLEPE-EKQALKRLVE------EELLKMQVDEA-ASREDKLDLTKK 78
Query: 235 KKKAPLAKGGRKKKKKKGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEEPESKAKAPQQ 294
K+ P ++K+ + F + E DY + + S AK
Sbjct: 79 GKRPPTPCSDPERKRFR------FNSESESGSEASSPDYFGPPAKNGVAAEVSPAKEENP 132
Query: 295 EEGPKGVDEQSDSSEESEEEKPPEEDKEEEEEK-------KAPTPQEKKRRKDSSEESDS 347
K V+E SD + + E+ EEEEK K P +++ K S +
Sbjct: 133 RRASKAVEESSDEERQRDLPAQRGEESSEEEEKGYKGKTRKKPVVKKQAPGKASVSRKQA 192
Query: 348 SEESDIDSEASSALFMAKK 366
EES+ +SEA AKK
Sbjct: 193 REESE-ESEAEPVQRTAKK 210
>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
sapiens]
Length = 699
Score = 58.9 bits (141), Expect = 1e-08
Identities = 64/253 (25%), Positives = 105/253 (41%), Gaps = 37/253 (14%)
Query: 227 EGGRVPKAKKKA--PLAKGGRKKKKKKGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEE 284
+ +VP+ K +A P+AK K KKK S DS+D E +EV Q
Sbjct: 59 KSAKVPERKLQANGPVAK----KAKKKASSS----DSEDSSEEEEEV----------QGP 100
Query: 285 PESKAKAPQQEEGPKGVDEQSDSSEESEEEKPPEEDKEEEEEK----KAPTPQEK----- 335
P KA P + G + +SE S E+ ++D EE+++K K PQ K
Sbjct: 101 PAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAP 160
Query: 336 -KRRKDSSEESDSSEESDIDSEASSALFMAKKKTPPKRERKPSGGSSRGNSRPGTPSAEG 394
K+ K S +SDSS E + + K K KP+ + + G ++
Sbjct: 161 PKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPK--IANGKAASSS 218
Query: 395 GSTSSTLRAAASKLEQGKRVSEMPAAKRLRLDTGPQSLSGKSTPQPPSGKTTPNSGDVQV 454
S+SS+ + S+ E+ + K+ + P + +TP S + +S D
Sbjct: 219 SSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAP--VKAATTPTRKSSSSEDSSSD--- 273
Query: 455 TEDAVRRYLTRKP 467
E+ ++ + KP
Sbjct: 274 EEEEQKKPMKNKP 286
Score = 58.5 bits (140), Expect = 1e-08
Identities = 78/282 (27%), Positives = 112/282 (39%), Gaps = 32/282 (11%)
Query: 217 SSDASDASGEEGG-RVPKAKKKAPLAK------GGRKKKKKKGSDDEAFEDSDDGDFEGQ 269
SSD+ D+S EE + P AKK A AK G K + S E E SDD D E Q
Sbjct: 84 SSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSE--ESSDDDDEEDQ 141
Query: 270 EVDYMSDGSSSSQEEPESKA-KAPQQEEGPKGVDEQSDSSEES---EEEKPPEEDKEEEE 325
+ + G +P++KA KAP ++ K D SDSS E + +KP +
Sbjct: 142 KKQPVQKGV-----KPQAKAAKAPPKKA--KSSDSDSDSSSEDEPPKNQKPKITPVTVKA 194
Query: 326 EKKAP------TPQEKKRRKDSSEESDSSEESDIDSEASSALFMAKKKTPPKR-ERKPSG 378
+ KAP P+ + SS S SS S DSE A KK P K+ K
Sbjct: 195 QTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPV 254
Query: 379 GSSRGNSRPGTPSAEGGSTSSTLRAAASKLEQGKRVSEMPAAKRLRLDTGPQSLSGKSTP 438
++ +R + S + S + K + G S P + P+ G P
Sbjct: 255 KAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSA-----PPPKKSLGTQPP 309
Query: 439 QPPSGKTTPNSGDVQVTEDAVRRYLTRKPMTTKDLLKKFQTK 480
+ K P ++++ K TK ++ K TK
Sbjct: 310 KKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTK 351
Score = 55.8 bits (133), Expect = 9e-08
Identities = 84/380 (22%), Positives = 139/380 (36%), Gaps = 90/380 (23%)
Query: 184 DQDQDEDEEEKEKRG-----------RRKASELRIHDLEDDLEMSSDASDASGEEGGRVP 232
++ D+D+EE +K+ KA + + D + SS+ ++ P
Sbjct: 130 EESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITP 189
Query: 233 ---KAKKKAPLAKGGRKKKK----KKGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEEP 285
KA+ KAP K R K K S + S D +E + + +++
Sbjct: 190 VTVKAQTKAP-PKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQV 248
Query: 286 ESKA--KAPQQEEGPKGVDEQSDSSEESEEEKP------------------PEEDKEEEE 325
+KA KA E S S EE E++KP P++ +
Sbjct: 249 VAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQP 308
Query: 326 EKKAPTPQEK-KRRKDSSEESDSSEESDIDSEASSALFMAKKKTPPKRE----------- 373
KKA Q+ + +DSS+ESDSS E + + + A K PP ++
Sbjct: 309 PKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDS 368
Query: 374 ---------RKPSGGSSRGNSRPGT--------PSAE------GGSTSSTLRAAASKLEQ 410
KP+G + +++P P+A GG T +A +S E+
Sbjct: 369 DSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEE 428
Query: 411 GKRVSEMPAAKRLRLDTGPQ-------SLSGKSTPQPPSGKTTPNSGDVQVTEDAVRRYL 463
SE K++ T P+ SL K PQ + + + D +E+
Sbjct: 429 ESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQ--GSRDSSSDSDSSSSEE------ 480
Query: 464 TRKPMTTKDLLKKFQTKKTG 483
+ T+K +KK K G
Sbjct: 481 -EEEKTSKSAVKKKPQKVAG 499
Score = 55.1 bits (131), Expect = 2e-07
Identities = 77/309 (24%), Positives = 117/309 (37%), Gaps = 70/309 (22%)
Query: 186 DQDEDEEEKEKRGRRKA----SELRIHDLEDDLEMSSDASDASGEEGGRVPK-------- 233
D+ + E+EK+ KA + + + E SSD+SD+ E P
Sbjct: 327 DESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKN 386
Query: 234 ------AKKKAPLAKGGRKKKKKKGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEE--- 284
K+P K K+ G + D +E SSSS+EE
Sbjct: 387 SSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEE-------SSSSEEEKTK 439
Query: 285 -------PESKAKAPQQ---EEGPKGV-----DEQSDSSEESEEEKPPEEDKEEEEEKKA 329
P++ AKA ++ P+G D S SSEE EEEK + +++ +K A
Sbjct: 440 KMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEE-EEEKTSKSAVKKKPQKVA 498
Query: 330 --PTPQEKKRRKDSSEESDSSEESDIDSEASSALFMAKKKTPPKRERKPSGGSSRGNSRP 387
P + K ES +S SD SE + E K G +G+ RP
Sbjct: 499 GGAAPSKPASAKKGKAESSNSSSSDDSSE--------------EEEEKLKG---KGSPRP 541
Query: 388 GTPSAEGGSTSSTLRAAASK----LEQGKRVSEMPAAKRLRLDTGPQSLSGKSTPQPPSG 443
P A G S + A+K E+ K+ + + +K L Q+ + K P +
Sbjct: 542 QAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQAK 601
Query: 444 K---TTPNS 449
K TPN+
Sbjct: 602 KIKLQTPNT 610
Score = 48.9 bits (115), Expect = 1e-05
Identities = 51/226 (22%), Positives = 89/226 (39%), Gaps = 28/226 (12%)
Query: 213 DLEMSSDASDASGEEGGRV------PKAKKKAPLAKGGRKKKKKKGSDDEAFEDSDDGDF 266
D S + S +S EE + PKA KA L+ K+ +GS D S D D
Sbjct: 422 DSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPA--KQAPQGSRDS----SSDSDS 475
Query: 267 EGQEVDYMSDGSSSSQEEPESKAKAPQQEEGPKGVDEQSDSSEESEEEKPPEEDKEEEEE 326
E + S+ +++P+ A + +++SS S + EE++E+ +
Sbjct: 476 SSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKG 535
Query: 327 KKAPTPQEKKRR-------------KDSSEESDSSEESDIDSEASSALFMAKKKTPPKRE 373
K +P PQ K K+S EE + +++ + S +L K+ K
Sbjct: 536 KGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEA 595
Query: 374 RKPSGGSSR---GNSRPGTPSAEGGSTSSTLRAAASKLEQGKRVSE 416
P + N+ P E ++S R ++E RV++
Sbjct: 596 ETPQAKKIKLQTPNTFPKRKKGEKRASSPFRRVREEEIEVDSRVAD 641
Score = 42.4 bits (98), Expect = 0.001
Identities = 62/260 (23%), Positives = 100/260 (38%), Gaps = 58/260 (22%)
Query: 184 DQDQDEDEEEKEKR----GRRKASELRIHDL------EDDLEMSSDA-SDASGEEGGRVP 232
+++ EEEK K+ + KA+ L + + SSD+ S +S EE +
Sbjct: 427 EEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTS 486
Query: 233 KA--KKKAPLAKGGRKKKK----KKGSDDEAFEDSDDGDFEGQEVDYMSDGS-------- 278
K+ KKK GG K KKG + + S D E +E GS
Sbjct: 487 KSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKA 546
Query: 279 --------------SSSQEEPESKAKAP--QQEEGPKGVDEQSDSSEESEE--------E 314
+S+EE E K KA + G +Q+++++E+E +
Sbjct: 547 NGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQAKKIKLQ 606
Query: 315 KPPEEDKEEEEEKKAPTPQEKKRRK---------DSSEESDSSEESDIDSEASSALFMAK 365
P K ++ EK+A +P + R + D+S ++ D A+ L K
Sbjct: 607 TPNTFPKRKKGEKRASSPFRRVREEEIEVDSRVADNSFDAKRGAAGDWGERANQVLKFTK 666
Query: 366 KKTPPKRERKPSGGSSRGNS 385
K+ + K GS RG S
Sbjct: 667 GKSFRHEKTKKKRGSYRGGS 686
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.304 0.124 0.338
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,656,021
Number of Sequences: 37866
Number of extensions: 1290083
Number of successful extensions: 40459
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1016
Number of HSP's successfully gapped in prelim test: 1431
Number of HSP's that attempted gapping in prelim test: 9947
Number of HSP's gapped (non-prelim): 13216
length of query: 517
length of database: 18,247,518
effective HSP length: 107
effective length of query: 410
effective length of database: 14,195,856
effective search space: 5820300960
effective search space used: 5820300960
T: 11
A: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.