Search of human proteins with 15553127

Search of human proteins with 15553127

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|15553127 hexokinase 2 [Homo sapiens]
         (917 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|15553127 hexokinase 2 [Homo sapiens]                              1843   0.0  
gi|188497754 hexokinase 1 isoform HKI [Homo sapiens]                 1398   0.0  
gi|15991829 hexokinase 1 isoform HKI-ta/tb [Homo sapiens]            1369   0.0  
gi|15991831 hexokinase 1 isoform HKI-ta/tb [Homo sapiens]            1369   0.0  
gi|188497750 hexokinase 1 isoform HKI-td [Homo sapiens]              1368   0.0  
gi|15991827 hexokinase 1 isoform HKI-R [Homo sapiens]                1368   0.0  
gi|156151420 hexokinase domain containing 1 [Homo sapiens]           1308   0.0  
gi|194097330 hexokinase 3 [Homo sapiens]                             1013   0.0  
gi|4503951 glucokinase isoform 1 [Homo sapiens]                       520   e-147
gi|15967161 glucokinase isoform 3 [Homo sapiens]                      518   e-146
gi|15967159 glucokinase isoform 2 [Homo sapiens]                      518   e-146
gi|134254462 ribosomal modification protein rimK-like family mem...    33   1.2  
gi|50658079 tubulin tyrosine ligase-like family, member 5 [Homo ...    33   1.6  
gi|164663810 ribosomal modification protein rimK-like family mem...    32   2.7  
gi|65301164 very low density lipoprotein receptor isoform b [Hom...    30   7.9  
gi|65301167 very low density lipoprotein receptor isoform a [Hom...    30   7.9  
gi|51093830 bicaudal D homolog 1 isoform 2 [Homo sapiens]              30   7.9  
gi|51039802 bicaudal D homolog 1 isoform 1 [Homo sapiens]              30   7.9  

>gi|15553127 hexokinase 2 [Homo sapiens]
          Length = 917

 Score = 1843 bits (4774), Expect = 0.0
 Identities = 917/917 (100%), Positives = 917/917 (100%)

Query: 1   MIASHLLAYFFTELNHDQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAA 60
           MIASHLLAYFFTELNHDQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAA
Sbjct: 1   MIASHLLAYFFTELNHDQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAA 60

Query: 61  VKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMR 120
           VKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMR
Sbjct: 61  VKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMR 120

Query: 121 GSGTQLFDHIAECLANFMDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGV 180
           GSGTQLFDHIAECLANFMDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGV
Sbjct: 121 GSGTQLFDHIAECLANFMDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGV 180

Query: 181 EGRDVVALIRKAIQRRGDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYME 240
           EGRDVVALIRKAIQRRGDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYME
Sbjct: 181 EGRDVVALIRKAIQRRGDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYME 240

Query: 241 EMRHIDMVEGDEGRMCINMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGM 300
           EMRHIDMVEGDEGRMCINMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGM
Sbjct: 241 EMRHIDMVEGDEGRMCINMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGM 300

Query: 301 YMGELVRLILVKMAKEELLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLG 360
           YMGELVRLILVKMAKEELLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLG
Sbjct: 301 YMGELVRLILVKMAKEELLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLG 360

Query: 361 LDPTQEDCVATHRICQIVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKH 420
           LDPTQEDCVATHRICQIVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKH
Sbjct: 361 LDPTQEDCVATHRICQIVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKH 420

Query: 421 PHFAKRLHKTVRRLVPGCDVRFLRSEDGSGKGAAMVTAVAYRLADQHRARQKTLEHLQLS 480
           PHFAKRLHKTVRRLVPGCDVRFLRSEDGSGKGAAMVTAVAYRLADQHRARQKTLEHLQLS
Sbjct: 421 PHFAKRLHKTVRRLVPGCDVRFLRSEDGSGKGAAMVTAVAYRLADQHRARQKTLEHLQLS 480

Query: 481 HDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRV 540
           HDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRV
Sbjct: 481 HDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRV 540

Query: 541 LLVRVRNGKWGGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGF 600
           LLVRVRNGKWGGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGF
Sbjct: 541 LLVRVRNGKWGGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGF 600

Query: 601 TFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVG 660
           TFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVG
Sbjct: 601 TFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVG 660

Query: 661 TMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEGRMCVNMEWGAFGDNGCLDD 720
           TMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEGRMCVNMEWGAFGDNGCLDD
Sbjct: 661 TMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEGRMCVNMEWGAFGDNGCLDD 720

Query: 721 FRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRG 780
           FRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRG
Sbjct: 721 FRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRG 780

Query: 781 IFETKFLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAA 840
           IFETKFLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAA
Sbjct: 781 IFETKFLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAA 840

Query: 841 VVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKDLAPKCDVSFLQSEDGSGKG 900
           VVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKDLAPKCDVSFLQSEDGSGKG
Sbjct: 841 VVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKDLAPKCDVSFLQSEDGSGKG 900

Query: 901 AALITAVACRIREAGQR 917
           AALITAVACRIREAGQR
Sbjct: 901 AALITAVACRIREAGQR 917


>gi|188497754 hexokinase 1 isoform HKI [Homo sapiens]
          Length = 917

 Score = 1398 bits (3618), Expect = 0.0
 Identities = 673/912 (73%), Positives = 793/912 (86%)

Query: 1   MIASHLLAYFFTELNHDQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAA 60
           MIA+ LLAY+FTEL  DQV+K+D+YLY MRLSDETL++I  RFRKEM+ GL    +PTA 
Sbjct: 1   MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTAT 60

Query: 61  VKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMR 120
           VKMLPTFVRS PDG+E G+F+ALDLGG++FR+L V+V     Q V ME+++Y  PE+I+ 
Sbjct: 61  VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVH 120

Query: 121 GSGTQLFDHIAECLANFMDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGV 180
           GSG+QLFDH+AECL +FM+K +IKDKKLP+GFTFSFPC Q+K+DE+ L++WTK FK+SGV
Sbjct: 121 GSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGV 180

Query: 181 EGRDVVALIRKAIQRRGDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYME 240
           EG DVV L+ KAI++RGD+D +IVAVVNDTVGTMMTCGYDD +CE+GLI+GTG+NACYME
Sbjct: 181 EGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYME 240

Query: 241 EMRHIDMVEGDEGRMCINMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGM 300
           E+RHID+VEGDEGRMCIN EWGAFGDDGSL DIRTEFD+EID GSLNPGKQLFEKM+SGM
Sbjct: 241 ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGM 300

Query: 301 YMGELVRLILVKMAKEELLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLG 360
           Y+GELVRLILVKMAKE LLF G+++PELL  G+F T D+S IE  K+G+  A+E+L RLG
Sbjct: 301 YLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLG 360

Query: 361 LDPTQEDCVATHRICQIVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKH 420
           ++P+ +DCV+   +C IVS RSA+L AATL A+L R+++NKG  RLR+T+GVDGS+YK H
Sbjct: 361 VEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTH 420

Query: 421 PHFAKRLHKTVRRLVPGCDVRFLRSEDGSGKGAAMVTAVAYRLADQHRARQKTLEHLQLS 480
           P +++R HKT+RRLVP  DVRFL SE GSGKGAAMVTAVAYRLA+QHR  ++TL H  L+
Sbjct: 421 PQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLT 480

Query: 481 HDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRV 540
            D LLEVK+RM+ EME GL K+TH +A VKMLP++V  TPDGTE GDFLALDLGGTNFRV
Sbjct: 481 KDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRV 540

Query: 541 LLVRVRNGKWGGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGF 600
           LLV++R+GK   VEMHNKIYAIP E+M GTG+ELFDHIV CI+DFL+YMG+KG  +PLGF
Sbjct: 541 LLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGF 600

Query: 601 TFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVG 660
           TFSFPCQQ SLD  IL+ WTKGFKA+ C G DVVTLL++AI RREEFDLDVVAVVNDTVG
Sbjct: 601 TFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVG 660

Query: 661 TMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEGRMCVNMEWGAFGDNGCLDD 720
           TMMTC +E+P CEVGLIVGTGSNACYMEEM+NVE+VEG++G+MC+NMEWGAFGDNGCLDD
Sbjct: 661 TMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDD 720

Query: 721 FRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRG 780
            RT +D  VDE SLN GKQR+EKMISGMYLGEIVRNILIDFTK+G LFRG+ISE LKTRG
Sbjct: 721 IRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRG 780

Query: 781 IFETKFLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAA 840
           IFETKFLSQIESD LALLQVRAILQ LGL STCDDSI+VK VC VV+RRAAQLCGAGMAA
Sbjct: 781 IFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAA 840

Query: 841 VVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKDLAPKCDVSFLQSEDGSGKG 900
           VVD+IRENRGLD L VTVGVDGTLYKLHPHF+++MH+TVK+L+PKC+VSFL SEDGSGKG
Sbjct: 841 VVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKG 900

Query: 901 AALITAVACRIR 912
           AALITAV  R+R
Sbjct: 901 AALITAVGVRLR 912



 Score =  523 bits (1348), Expect = e-148
 Identities = 248/449 (55%), Positives = 339/449 (75%)

Query: 465 DQHRARQKTLEHLQLSHDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTE 524
           DQ +   K L  ++LS + L+++  R + EM+ GLS++ + +A VKMLPT+V + PDG+E
Sbjct: 17  DQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSE 76

Query: 525 KGDFLALDLGGTNFRVLLVRVRNGKWGGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIAD 584
           KGDF+ALDLGG++FR+L V+V + K   V M +++Y  P+ ++HG+G +LFDH+ +C+ D
Sbjct: 77  KGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGD 136

Query: 585 FLEYMGMKGVSLPLGFTFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRR 644
           F+E   +K   LP+GFTFSFPCQQ+ +DE+IL+ WTK FKASG EG DVV LL +AI +R
Sbjct: 137 FMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKR 196

Query: 645 EEFDLDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEGRMC 704
            ++D ++VAVVNDTVGTMMTCG++D HCEVGLI+GTG+NACYMEE+R+++LVEG+EGRMC
Sbjct: 197 GDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMC 256

Query: 705 VNMEWGAFGDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKR 764
           +N EWGAFGD+G L+D RTEFD  +D  SLNPGKQ FEKM+SGMYLGE+VR IL+   K 
Sbjct: 257 INTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKE 316

Query: 765 GLLFRGRISERLKTRGIFETKFLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVCT 824
           GLLF GRI+  L TRG F T  +S IE +   L   + IL  LG+E + DD + V+ VCT
Sbjct: 317 GLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCT 376

Query: 825 VVARRAAQLCGAGMAAVVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKDLAP 884
           +V+ R+A L  A + A+++R+R+N+G   L+ TVGVDG+LYK HP +++  H+T++ L P
Sbjct: 377 IVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVP 436

Query: 885 KCDVSFLQSEDGSGKGAALITAVACRIRE 913
             DV FL SE GSGKGAA++TAVA R+ E
Sbjct: 437 DSDVRFLLSESGSGKGAAMVTAVAYRLAE 465


>gi|15991829 hexokinase 1 isoform HKI-ta/tb [Homo sapiens]
          Length = 921

 Score = 1369 bits (3543), Expect = 0.0
 Identities = 658/892 (73%), Positives = 776/892 (86%)

Query: 21  KVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEF 80
           ++D+YLY MRLSDETL++I  RFRKEM+ GL    +PTA VKMLPTFVRS PDG+E G+F
Sbjct: 25  EIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDF 84

Query: 81  LALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDK 140
           +ALDLGG++FR+L V+V     Q V ME+++Y  PE+I+ GSG+QLFDH+AECL +FM+K
Sbjct: 85  IALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEK 144

Query: 141 LQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRRGDFD 200
            +IKDKKLP+GFTFSFPC Q+K+DE+ L++WTK FK+SGVEG DVV L+ KAI++RGD+D
Sbjct: 145 RKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYD 204

Query: 201 IDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRMCINME 260
            +IVAVVNDTVGTMMTCGYDD +CE+GLI+GTG+NACYMEE+RHID+VEGDEGRMCIN E
Sbjct: 205 ANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTE 264

Query: 261 WGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEELLF 320
           WGAFGDDGSL DIRTEFD+EID GSLNPGKQLFEKM+SGMY+GELVRLILVKMAKE LLF
Sbjct: 265 WGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLF 324

Query: 321 GGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLGLDPTQEDCVATHRICQIVST 380
            G+++PELL  G+F T D+S IE  K+G+  A+E+L RLG++P+ +DCV+   +C IVS 
Sbjct: 325 EGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSF 384

Query: 381 RSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRRLVPGCDV 440
           RSA+L AATL A+L R+++NKG  RLR+T+GVDGS+YK HP +++R HKT+RRLVP  DV
Sbjct: 385 RSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDV 444

Query: 441 RFLRSEDGSGKGAAMVTAVAYRLADQHRARQKTLEHLQLSHDQLLEVKRRMKVEMERGLS 500
           RFL SE GSGKGAAMVTAVAYRLA+QHR  ++TL H  L+ D LLEVK+RM+ EME GL 
Sbjct: 445 RFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLR 504

Query: 501 KETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKWGGVEMHNKIY 560
           K+TH +A VKMLP++V  TPDGTE GDFLALDLGGTNFRVLLV++R+GK   VEMHNKIY
Sbjct: 505 KQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIY 564

Query: 561 AIPQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNSLDESILLKWT 620
           AIP E+M GTG+ELFDHIV CI+DFL+YMG+KG  +PLGFTFSFPCQQ SLD  IL+ WT
Sbjct: 565 AIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWT 624

Query: 621 KGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGT 680
           KGFKA+ C G DVVTLL++AI RREEFDLDVVAVVNDTVGTMMTC +E+P CEVGLIVGT
Sbjct: 625 KGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGT 684

Query: 681 GSNACYMEEMRNVELVEGEEGRMCVNMEWGAFGDNGCLDDFRTEFDVAVDELSLNPGKQR 740
           GSNACYMEEM+NVE+VEG++G+MC+NMEWGAFGDNGCLDD RT +D  VDE SLN GKQR
Sbjct: 685 GSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQR 744

Query: 741 FEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRGIFETKFLSQIESDCLALLQV 800
           +EKMISGMYLGEIVRNILIDFTK+G LFRG+ISE LKTRGIFETKFLSQIESD LALLQV
Sbjct: 745 YEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQV 804

Query: 801 RAILQHLGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAAVVDRIRENRGLDALKVTVGV 860
           RAILQ LGL STCDDSI+VK VC VV+RRAAQLCGAGMAAVVD+IRENRGLD L VTVGV
Sbjct: 805 RAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGV 864

Query: 861 DGTLYKLHPHFAKVMHETVKDLAPKCDVSFLQSEDGSGKGAALITAVACRIR 912
           DGTLYKLHPHF+++MH+TVK+L+PKC+VSFL SEDGSGKGAALITAV  R+R
Sbjct: 865 DGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRLR 916



 Score =  546 bits (1406), Expect = e-155
 Identities = 258/447 (57%), Positives = 344/447 (76%)

Query: 17  DQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTE 76
           +Q +++++ L H  L+ + LLE+ KR R EME GL   TH  A VKMLP+FVR TPDGTE
Sbjct: 469 EQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTE 528

Query: 77  HGEFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLAN 136
           +G+FLALDLGGTNFRVL VK+     + VEM N+IYAIP +IM+G+G +LFDHI  C+++
Sbjct: 529 NGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISD 588

Query: 137 FMDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRR 196
           F+D + IK  ++PLGFTFSFPC QT LD   L++WTKGFK++   G DVV L+R AI+RR
Sbjct: 589 FLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRR 648

Query: 197 GDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRMC 256
            +FD+D+VAVVNDTVGTMMTC Y++  CE+GLIVGTGSNACYMEEM++++MVEGD+G+MC
Sbjct: 649 EEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMC 708

Query: 257 INMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKE 316
           INMEWGAFGD+G L+DIRT +D+ +D  SLN GKQ +EKMISGMY+GE+VR IL+   K+
Sbjct: 709 INMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKK 768

Query: 317 ELLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLGLDPTQEDCVATHRICQ 376
             LF G++S  L   G FETK +S IE ++  + + R +L +LGL+ T +D +    +C 
Sbjct: 769 GFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCG 828

Query: 377 IVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRRLVP 436
           +VS R+A LC A +AAV+ +I+EN+G +RL  T+GVDG++YK HPHF++ +H+TV+ L P
Sbjct: 829 VVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSP 888

Query: 437 GCDVRFLRSEDGSGKGAAMVTAVAYRL 463
            C+V FL SEDGSGKGAA++TAV  RL
Sbjct: 889 KCNVSFLLSEDGSGKGAALITAVGVRL 915



 Score =  521 bits (1342), Expect = e-147
 Identities = 246/442 (55%), Positives = 336/442 (76%)

Query: 472 KTLEHLQLSHDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLAL 531
           K L  ++LS + L+++  R + EM+ GLS++ + +A VKMLPT+V + PDG+EKGDF+AL
Sbjct: 28  KYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFIAL 87

Query: 532 DLGGTNFRVLLVRVRNGKWGGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIADFLEYMGM 591
           DLGG++FR+L V+V + K   V M +++Y  P+ ++HG+G +LFDH+ +C+ DF+E   +
Sbjct: 88  DLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKI 147

Query: 592 KGVSLPLGFTFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDV 651
           K   LP+GFTFSFPCQQ+ +DE+IL+ WTK FKASG EG DVV LL +AI +R ++D ++
Sbjct: 148 KDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANI 207

Query: 652 VAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEGRMCVNMEWGA 711
           VAVVNDTVGTMMTCG++D HCEVGLI+GTG+NACYMEE+R+++LVEG+EGRMC+N EWGA
Sbjct: 208 VAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTEWGA 267

Query: 712 FGDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGR 771
           FGD+G L+D RTEFD  +D  SLNPGKQ FEKM+SGMYLGE+VR IL+   K GLLF GR
Sbjct: 268 FGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFEGR 327

Query: 772 ISERLKTRGIFETKFLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVCTVVARRAA 831
           I+  L TRG F T  +S IE +   L   + IL  LG+E + DD + V+ VCT+V+ R+A
Sbjct: 328 ITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFRSA 387

Query: 832 QLCGAGMAAVVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKDLAPKCDVSFL 891
            L  A + A+++R+R+N+G   L+ TVGVDG+LYK HP +++  H+T++ L P  DV FL
Sbjct: 388 NLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDVRFL 447

Query: 892 QSEDGSGKGAALITAVACRIRE 913
            SE GSGKGAA++TAVA R+ E
Sbjct: 448 LSESGSGKGAAMVTAVAYRLAE 469


>gi|15991831 hexokinase 1 isoform HKI-ta/tb [Homo sapiens]
          Length = 921

 Score = 1369 bits (3543), Expect = 0.0
 Identities = 658/892 (73%), Positives = 776/892 (86%)

Query: 21  KVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEF 80
           ++D+YLY MRLSDETL++I  RFRKEM+ GL    +PTA VKMLPTFVRS PDG+E G+F
Sbjct: 25  EIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDF 84

Query: 81  LALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDK 140
           +ALDLGG++FR+L V+V     Q V ME+++Y  PE+I+ GSG+QLFDH+AECL +FM+K
Sbjct: 85  IALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEK 144

Query: 141 LQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRRGDFD 200
            +IKDKKLP+GFTFSFPC Q+K+DE+ L++WTK FK+SGVEG DVV L+ KAI++RGD+D
Sbjct: 145 RKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYD 204

Query: 201 IDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRMCINME 260
            +IVAVVNDTVGTMMTCGYDD +CE+GLI+GTG+NACYMEE+RHID+VEGDEGRMCIN E
Sbjct: 205 ANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTE 264

Query: 261 WGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEELLF 320
           WGAFGDDGSL DIRTEFD+EID GSLNPGKQLFEKM+SGMY+GELVRLILVKMAKE LLF
Sbjct: 265 WGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLF 324

Query: 321 GGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLGLDPTQEDCVATHRICQIVST 380
            G+++PELL  G+F T D+S IE  K+G+  A+E+L RLG++P+ +DCV+   +C IVS 
Sbjct: 325 EGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSF 384

Query: 381 RSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRRLVPGCDV 440
           RSA+L AATL A+L R+++NKG  RLR+T+GVDGS+YK HP +++R HKT+RRLVP  DV
Sbjct: 385 RSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDV 444

Query: 441 RFLRSEDGSGKGAAMVTAVAYRLADQHRARQKTLEHLQLSHDQLLEVKRRMKVEMERGLS 500
           RFL SE GSGKGAAMVTAVAYRLA+QHR  ++TL H  L+ D LLEVK+RM+ EME GL 
Sbjct: 445 RFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLR 504

Query: 501 KETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKWGGVEMHNKIY 560
           K+TH +A VKMLP++V  TPDGTE GDFLALDLGGTNFRVLLV++R+GK   VEMHNKIY
Sbjct: 505 KQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIY 564

Query: 561 AIPQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNSLDESILLKWT 620
           AIP E+M GTG+ELFDHIV CI+DFL+YMG+KG  +PLGFTFSFPCQQ SLD  IL+ WT
Sbjct: 565 AIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWT 624

Query: 621 KGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGT 680
           KGFKA+ C G DVVTLL++AI RREEFDLDVVAVVNDTVGTMMTC +E+P CEVGLIVGT
Sbjct: 625 KGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGT 684

Query: 681 GSNACYMEEMRNVELVEGEEGRMCVNMEWGAFGDNGCLDDFRTEFDVAVDELSLNPGKQR 740
           GSNACYMEEM+NVE+VEG++G+MC+NMEWGAFGDNGCLDD RT +D  VDE SLN GKQR
Sbjct: 685 GSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQR 744

Query: 741 FEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRGIFETKFLSQIESDCLALLQV 800
           +EKMISGMYLGEIVRNILIDFTK+G LFRG+ISE LKTRGIFETKFLSQIESD LALLQV
Sbjct: 745 YEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQV 804

Query: 801 RAILQHLGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAAVVDRIRENRGLDALKVTVGV 860
           RAILQ LGL STCDDSI+VK VC VV+RRAAQLCGAGMAAVVD+IRENRGLD L VTVGV
Sbjct: 805 RAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGV 864

Query: 861 DGTLYKLHPHFAKVMHETVKDLAPKCDVSFLQSEDGSGKGAALITAVACRIR 912
           DGTLYKLHPHF+++MH+TVK+L+PKC+VSFL SEDGSGKGAALITAV  R+R
Sbjct: 865 DGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRLR 916



 Score =  546 bits (1406), Expect = e-155
 Identities = 258/447 (57%), Positives = 344/447 (76%)

Query: 17  DQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTE 76
           +Q +++++ L H  L+ + LLE+ KR R EME GL   TH  A VKMLP+FVR TPDGTE
Sbjct: 469 EQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTE 528

Query: 77  HGEFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLAN 136
           +G+FLALDLGGTNFRVL VK+     + VEM N+IYAIP +IM+G+G +LFDHI  C+++
Sbjct: 529 NGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISD 588

Query: 137 FMDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRR 196
           F+D + IK  ++PLGFTFSFPC QT LD   L++WTKGFK++   G DVV L+R AI+RR
Sbjct: 589 FLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRR 648

Query: 197 GDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRMC 256
            +FD+D+VAVVNDTVGTMMTC Y++  CE+GLIVGTGSNACYMEEM++++MVEGD+G+MC
Sbjct: 649 EEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMC 708

Query: 257 INMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKE 316
           INMEWGAFGD+G L+DIRT +D+ +D  SLN GKQ +EKMISGMY+GE+VR IL+   K+
Sbjct: 709 INMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKK 768

Query: 317 ELLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLGLDPTQEDCVATHRICQ 376
             LF G++S  L   G FETK +S IE ++  + + R +L +LGL+ T +D +    +C 
Sbjct: 769 GFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCG 828

Query: 377 IVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRRLVP 436
           +VS R+A LC A +AAV+ +I+EN+G +RL  T+GVDG++YK HPHF++ +H+TV+ L P
Sbjct: 829 VVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSP 888

Query: 437 GCDVRFLRSEDGSGKGAAMVTAVAYRL 463
            C+V FL SEDGSGKGAA++TAV  RL
Sbjct: 889 KCNVSFLLSEDGSGKGAALITAVGVRL 915



 Score =  521 bits (1342), Expect = e-147
 Identities = 246/442 (55%), Positives = 336/442 (76%)

Query: 472 KTLEHLQLSHDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLAL 531
           K L  ++LS + L+++  R + EM+ GLS++ + +A VKMLPT+V + PDG+EKGDF+AL
Sbjct: 28  KYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFIAL 87

Query: 532 DLGGTNFRVLLVRVRNGKWGGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIADFLEYMGM 591
           DLGG++FR+L V+V + K   V M +++Y  P+ ++HG+G +LFDH+ +C+ DF+E   +
Sbjct: 88  DLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKI 147

Query: 592 KGVSLPLGFTFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDV 651
           K   LP+GFTFSFPCQQ+ +DE+IL+ WTK FKASG EG DVV LL +AI +R ++D ++
Sbjct: 148 KDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANI 207

Query: 652 VAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEGRMCVNMEWGA 711
           VAVVNDTVGTMMTCG++D HCEVGLI+GTG+NACYMEE+R+++LVEG+EGRMC+N EWGA
Sbjct: 208 VAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTEWGA 267

Query: 712 FGDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGR 771
           FGD+G L+D RTEFD  +D  SLNPGKQ FEKM+SGMYLGE+VR IL+   K GLLF GR
Sbjct: 268 FGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFEGR 327

Query: 772 ISERLKTRGIFETKFLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVCTVVARRAA 831
           I+  L TRG F T  +S IE +   L   + IL  LG+E + DD + V+ VCT+V+ R+A
Sbjct: 328 ITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFRSA 387

Query: 832 QLCGAGMAAVVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKDLAPKCDVSFL 891
            L  A + A+++R+R+N+G   L+ TVGVDG+LYK HP +++  H+T++ L P  DV FL
Sbjct: 388 NLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDVRFL 447

Query: 892 QSEDGSGKGAALITAVACRIRE 913
            SE GSGKGAA++TAVA R+ E
Sbjct: 448 LSESGSGKGAAMVTAVAYRLAE 469


>gi|188497750 hexokinase 1 isoform HKI-td [Homo sapiens]
          Length = 905

 Score = 1368 bits (3542), Expect = 0.0
 Identities = 658/891 (73%), Positives = 775/891 (86%)

Query: 22  VDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEFL 81
           +D+YLY MRLSDETL++I  RFRKEM+ GL    +PTA VKMLPTFVRS PDG+E G+F+
Sbjct: 10  IDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFI 69

Query: 82  ALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDKL 141
           ALDLGG++FR+L V+V     Q V ME+++Y  PE+I+ GSG+QLFDH+AECL +FM+K 
Sbjct: 70  ALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKR 129

Query: 142 QIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRRGDFDI 201
           +IKDKKLP+GFTFSFPC Q+K+DE+ L++WTK FK+SGVEG DVV L+ KAI++RGD+D 
Sbjct: 130 KIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDA 189

Query: 202 DIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRMCINMEW 261
           +IVAVVNDTVGTMMTCGYDD +CE+GLI+GTG+NACYMEE+RHID+VEGDEGRMCIN EW
Sbjct: 190 NIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTEW 249

Query: 262 GAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEELLFG 321
           GAFGDDGSL DIRTEFD+EID GSLNPGKQLFEKM+SGMY+GELVRLILVKMAKE LLF 
Sbjct: 250 GAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFE 309

Query: 322 GKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLGLDPTQEDCVATHRICQIVSTR 381
           G+++PELL  G+F T D+S IE  K+G+  A+E+L RLG++P+ +DCV+   +C IVS R
Sbjct: 310 GRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFR 369

Query: 382 SASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRRLVPGCDVR 441
           SA+L AATL A+L R+++NKG  RLR+T+GVDGS+YK HP +++R HKT+RRLVP  DVR
Sbjct: 370 SANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDVR 429

Query: 442 FLRSEDGSGKGAAMVTAVAYRLADQHRARQKTLEHLQLSHDQLLEVKRRMKVEMERGLSK 501
           FL SE GSGKGAAMVTAVAYRLA+QHR  ++TL H  L+ D LLEVK+RM+ EME GL K
Sbjct: 430 FLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRK 489

Query: 502 ETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKWGGVEMHNKIYA 561
           +TH +A VKMLP++V  TPDGTE GDFLALDLGGTNFRVLLV++R+GK   VEMHNKIYA
Sbjct: 490 QTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYA 549

Query: 562 IPQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNSLDESILLKWTK 621
           IP E+M GTG+ELFDHIV CI+DFL+YMG+KG  +PLGFTFSFPCQQ SLD  IL+ WTK
Sbjct: 550 IPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTK 609

Query: 622 GFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTG 681
           GFKA+ C G DVVTLL++AI RREEFDLDVVAVVNDTVGTMMTC +E+P CEVGLIVGTG
Sbjct: 610 GFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTG 669

Query: 682 SNACYMEEMRNVELVEGEEGRMCVNMEWGAFGDNGCLDDFRTEFDVAVDELSLNPGKQRF 741
           SNACYMEEM+NVE+VEG++G+MC+NMEWGAFGDNGCLDD RT +D  VDE SLN GKQR+
Sbjct: 670 SNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRY 729

Query: 742 EKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRGIFETKFLSQIESDCLALLQVR 801
           EKMISGMYLGEIVRNILIDFTK+G LFRG+ISE LKTRGIFETKFLSQIESD LALLQVR
Sbjct: 730 EKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVR 789

Query: 802 AILQHLGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAAVVDRIRENRGLDALKVTVGVD 861
           AILQ LGL STCDDSI+VK VC VV+RRAAQLCGAGMAAVVD+IRENRGLD L VTVGVD
Sbjct: 790 AILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVD 849

Query: 862 GTLYKLHPHFAKVMHETVKDLAPKCDVSFLQSEDGSGKGAALITAVACRIR 912
           GTLYKLHPHF+++MH+TVK+L+PKC+VSFL SEDGSGKGAALITAV  R+R
Sbjct: 850 GTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRLR 900



 Score =  546 bits (1406), Expect = e-155
 Identities = 258/447 (57%), Positives = 344/447 (76%)

Query: 17  DQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTE 76
           +Q +++++ L H  L+ + LLE+ KR R EME GL   TH  A VKMLP+FVR TPDGTE
Sbjct: 453 EQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTE 512

Query: 77  HGEFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLAN 136
           +G+FLALDLGGTNFRVL VK+     + VEM N+IYAIP +IM+G+G +LFDHI  C+++
Sbjct: 513 NGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISD 572

Query: 137 FMDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRR 196
           F+D + IK  ++PLGFTFSFPC QT LD   L++WTKGFK++   G DVV L+R AI+RR
Sbjct: 573 FLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRR 632

Query: 197 GDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRMC 256
            +FD+D+VAVVNDTVGTMMTC Y++  CE+GLIVGTGSNACYMEEM++++MVEGD+G+MC
Sbjct: 633 EEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMC 692

Query: 257 INMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKE 316
           INMEWGAFGD+G L+DIRT +D+ +D  SLN GKQ +EKMISGMY+GE+VR IL+   K+
Sbjct: 693 INMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKK 752

Query: 317 ELLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLGLDPTQEDCVATHRICQ 376
             LF G++S  L   G FETK +S IE ++  + + R +L +LGL+ T +D +    +C 
Sbjct: 753 GFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCG 812

Query: 377 IVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRRLVP 436
           +VS R+A LC A +AAV+ +I+EN+G +RL  T+GVDG++YK HPHF++ +H+TV+ L P
Sbjct: 813 VVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSP 872

Query: 437 GCDVRFLRSEDGSGKGAAMVTAVAYRL 463
            C+V FL SEDGSGKGAA++TAV  RL
Sbjct: 873 KCNVSFLLSEDGSGKGAALITAVGVRL 899



 Score =  521 bits (1343), Expect = e-148
 Identities = 247/447 (55%), Positives = 337/447 (75%)

Query: 467 HRARQKTLEHLQLSHDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTEKG 526
           H    K L  ++LS + L+++  R + EM+ GLS++ + +A VKMLPT+V + PDG+EKG
Sbjct: 7   HDFIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKG 66

Query: 527 DFLALDLGGTNFRVLLVRVRNGKWGGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIADFL 586
           DF+ALDLGG++FR+L V+V + K   V M +++Y  P+ ++HG+G +LFDH+ +C+ DF+
Sbjct: 67  DFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFM 126

Query: 587 EYMGMKGVSLPLGFTFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRREE 646
           E   +K   LP+GFTFSFPCQQ+ +DE+IL+ WTK FKASG EG DVV LL +AI +R +
Sbjct: 127 EKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGD 186

Query: 647 FDLDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEGRMCVN 706
           +D ++VAVVNDTVGTMMTCG++D HCEVGLI+GTG+NACYMEE+R+++LVEG+EGRMC+N
Sbjct: 187 YDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCIN 246

Query: 707 MEWGAFGDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGL 766
            EWGAFGD+G L+D RTEFD  +D  SLNPGKQ FEKM+SGMYLGE+VR IL+   K GL
Sbjct: 247 TEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGL 306

Query: 767 LFRGRISERLKTRGIFETKFLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVCTVV 826
           LF GRI+  L TRG F T  +S IE +   L   + IL  LG+E + DD + V+ VCT+V
Sbjct: 307 LFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIV 366

Query: 827 ARRAAQLCGAGMAAVVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKDLAPKC 886
           + R+A L  A + A+++R+R+N+G   L+ TVGVDG+LYK HP +++  H+T++ L P  
Sbjct: 367 SFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDS 426

Query: 887 DVSFLQSEDGSGKGAALITAVACRIRE 913
           DV FL SE GSGKGAA++TAVA R+ E
Sbjct: 427 DVRFLLSESGSGKGAAMVTAVAYRLAE 453


>gi|15991827 hexokinase 1 isoform HKI-R [Homo sapiens]
          Length = 916

 Score = 1368 bits (3542), Expect = 0.0
 Identities = 658/891 (73%), Positives = 775/891 (86%)

Query: 22  VDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEFL 81
           +D+YLY MRLSDETL++I  RFRKEM+ GL    +PTA VKMLPTFVRS PDG+E G+F+
Sbjct: 21  IDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFI 80

Query: 82  ALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDKL 141
           ALDLGG++FR+L V+V     Q V ME+++Y  PE+I+ GSG+QLFDH+AECL +FM+K 
Sbjct: 81  ALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKR 140

Query: 142 QIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRRGDFDI 201
           +IKDKKLP+GFTFSFPC Q+K+DE+ L++WTK FK+SGVEG DVV L+ KAI++RGD+D 
Sbjct: 141 KIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDA 200

Query: 202 DIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRMCINMEW 261
           +IVAVVNDTVGTMMTCGYDD +CE+GLI+GTG+NACYMEE+RHID+VEGDEGRMCIN EW
Sbjct: 201 NIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTEW 260

Query: 262 GAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEELLFG 321
           GAFGDDGSL DIRTEFD+EID GSLNPGKQLFEKM+SGMY+GELVRLILVKMAKE LLF 
Sbjct: 261 GAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFE 320

Query: 322 GKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLGLDPTQEDCVATHRICQIVSTR 381
           G+++PELL  G+F T D+S IE  K+G+  A+E+L RLG++P+ +DCV+   +C IVS R
Sbjct: 321 GRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFR 380

Query: 382 SASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRRLVPGCDVR 441
           SA+L AATL A+L R+++NKG  RLR+T+GVDGS+YK HP +++R HKT+RRLVP  DVR
Sbjct: 381 SANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDVR 440

Query: 442 FLRSEDGSGKGAAMVTAVAYRLADQHRARQKTLEHLQLSHDQLLEVKRRMKVEMERGLSK 501
           FL SE GSGKGAAMVTAVAYRLA+QHR  ++TL H  L+ D LLEVK+RM+ EME GL K
Sbjct: 441 FLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRK 500

Query: 502 ETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKWGGVEMHNKIYA 561
           +TH +A VKMLP++V  TPDGTE GDFLALDLGGTNFRVLLV++R+GK   VEMHNKIYA
Sbjct: 501 QTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYA 560

Query: 562 IPQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNSLDESILLKWTK 621
           IP E+M GTG+ELFDHIV CI+DFL+YMG+KG  +PLGFTFSFPCQQ SLD  IL+ WTK
Sbjct: 561 IPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTK 620

Query: 622 GFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTG 681
           GFKA+ C G DVVTLL++AI RREEFDLDVVAVVNDTVGTMMTC +E+P CEVGLIVGTG
Sbjct: 621 GFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTG 680

Query: 682 SNACYMEEMRNVELVEGEEGRMCVNMEWGAFGDNGCLDDFRTEFDVAVDELSLNPGKQRF 741
           SNACYMEEM+NVE+VEG++G+MC+NMEWGAFGDNGCLDD RT +D  VDE SLN GKQR+
Sbjct: 681 SNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRY 740

Query: 742 EKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRGIFETKFLSQIESDCLALLQVR 801
           EKMISGMYLGEIVRNILIDFTK+G LFRG+ISE LKTRGIFETKFLSQIESD LALLQVR
Sbjct: 741 EKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVR 800

Query: 802 AILQHLGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAAVVDRIRENRGLDALKVTVGVD 861
           AILQ LGL STCDDSI+VK VC VV+RRAAQLCGAGMAAVVD+IRENRGLD L VTVGVD
Sbjct: 801 AILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVD 860

Query: 862 GTLYKLHPHFAKVMHETVKDLAPKCDVSFLQSEDGSGKGAALITAVACRIR 912
           GTLYKLHPHF+++MH+TVK+L+PKC+VSFL SEDGSGKGAALITAV  R+R
Sbjct: 861 GTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRLR 911



 Score =  546 bits (1406), Expect = e-155
 Identities = 258/447 (57%), Positives = 344/447 (76%)

Query: 17  DQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTE 76
           +Q +++++ L H  L+ + LLE+ KR R EME GL   TH  A VKMLP+FVR TPDGTE
Sbjct: 464 EQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTE 523

Query: 77  HGEFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLAN 136
           +G+FLALDLGGTNFRVL VK+     + VEM N+IYAIP +IM+G+G +LFDHI  C+++
Sbjct: 524 NGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISD 583

Query: 137 FMDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRR 196
           F+D + IK  ++PLGFTFSFPC QT LD   L++WTKGFK++   G DVV L+R AI+RR
Sbjct: 584 FLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRR 643

Query: 197 GDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRMC 256
            +FD+D+VAVVNDTVGTMMTC Y++  CE+GLIVGTGSNACYMEEM++++MVEGD+G+MC
Sbjct: 644 EEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMC 703

Query: 257 INMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKE 316
           INMEWGAFGD+G L+DIRT +D+ +D  SLN GKQ +EKMISGMY+GE+VR IL+   K+
Sbjct: 704 INMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKK 763

Query: 317 ELLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLGLDPTQEDCVATHRICQ 376
             LF G++S  L   G FETK +S IE ++  + + R +L +LGL+ T +D +    +C 
Sbjct: 764 GFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCG 823

Query: 377 IVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRRLVP 436
           +VS R+A LC A +AAV+ +I+EN+G +RL  T+GVDG++YK HPHF++ +H+TV+ L P
Sbjct: 824 VVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSP 883

Query: 437 GCDVRFLRSEDGSGKGAAMVTAVAYRL 463
            C+V FL SEDGSGKGAA++TAV  RL
Sbjct: 884 KCNVSFLLSEDGSGKGAALITAVGVRL 910



 Score =  521 bits (1342), Expect = e-147
 Identities = 246/442 (55%), Positives = 336/442 (76%)

Query: 472 KTLEHLQLSHDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLAL 531
           K L  ++LS + L+++  R + EM+ GLS++ + +A VKMLPT+V + PDG+EKGDF+AL
Sbjct: 23  KYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFIAL 82

Query: 532 DLGGTNFRVLLVRVRNGKWGGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIADFLEYMGM 591
           DLGG++FR+L V+V + K   V M +++Y  P+ ++HG+G +LFDH+ +C+ DF+E   +
Sbjct: 83  DLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKI 142

Query: 592 KGVSLPLGFTFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDV 651
           K   LP+GFTFSFPCQQ+ +DE+IL+ WTK FKASG EG DVV LL +AI +R ++D ++
Sbjct: 143 KDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANI 202

Query: 652 VAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEGRMCVNMEWGA 711
           VAVVNDTVGTMMTCG++D HCEVGLI+GTG+NACYMEE+R+++LVEG+EGRMC+N EWGA
Sbjct: 203 VAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTEWGA 262

Query: 712 FGDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGR 771
           FGD+G L+D RTEFD  +D  SLNPGKQ FEKM+SGMYLGE+VR IL+   K GLLF GR
Sbjct: 263 FGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFEGR 322

Query: 772 ISERLKTRGIFETKFLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVCTVVARRAA 831
           I+  L TRG F T  +S IE +   L   + IL  LG+E + DD + V+ VCT+V+ R+A
Sbjct: 323 ITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFRSA 382

Query: 832 QLCGAGMAAVVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKDLAPKCDVSFL 891
            L  A + A+++R+R+N+G   L+ TVGVDG+LYK HP +++  H+T++ L P  DV FL
Sbjct: 383 NLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDVRFL 442

Query: 892 QSEDGSGKGAALITAVACRIRE 913
            SE GSGKGAA++TAVA R+ E
Sbjct: 443 LSESGSGKGAAMVTAVAYRLAE 464


>gi|156151420 hexokinase domain containing 1 [Homo sapiens]
          Length = 917

 Score = 1308 bits (3385), Expect = 0.0
 Identities = 621/914 (67%), Positives = 775/914 (84%), Gaps = 1/914 (0%)

Query: 1   MIASHLLAYFFTELNHDQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAA 60
           M A HL+A++F++L  DQ++KVD++LYHMRLSD+TLL+I +RFR EMEKGL   T+PTAA
Sbjct: 1   MFAVHLMAFYFSKLKEDQIKKVDRFLYHMRLSDDTLLDIMRRFRAEMEKGLAKDTNPTAA 60

Query: 61  VKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMR 120
           VKMLPTFVR+ PDG+E+GEFL+LDLGG+ FRVL V+V + G + V+ME+Q Y  P +I+R
Sbjct: 61  VKMLPTFVRAIPDGSENGEFLSLDLGGSKFRVLKVQVAEEGKRHVQMESQFYPTPNEIIR 120

Query: 121 GSGTQLFDHIAECLANFMDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGV 180
           G+GT+LF+++A+CLA+FM    +K KKLPLG TFSFPC QTKL+E  L+SWTK FK+ GV
Sbjct: 121 GNGTELFEYVADCLADFMKTKDLKHKKLPLGLTFSFPCRQTKLEEGVLLSWTKKFKARGV 180

Query: 181 EGRDVVALIRKAIQRRGDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYME 240
           +  DVV+ + KA++R  D D+DI+A+VNDTVGTMMTC YDD  CE+G+I+GTG+NACYME
Sbjct: 181 QDTDVVSRLTKAMRRHKDMDVDILALVNDTVGTMMTCAYDDPYCEVGVIIGTGTNACYME 240

Query: 241 EMRHIDMVEGDEGRMCINMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGM 300
           +M +ID+VEGDEGRMCIN EWGAFGDDG+L DIRTEFD+E+D+GSLNPGKQLFEKMISG+
Sbjct: 241 DMSNIDLVEGDEGRMCINTEWGAFGDDGALEDIRTEFDRELDLGSLNPGKQLFEKMISGL 300

Query: 301 YMGELVRLILVKMAKEELLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLG 360
           Y+GELVRLIL+KMAK  LLFGG+ S  L   G+ ET+ ++ +E  K+G+   RE+L+ LG
Sbjct: 301 YLGELVRLILLKMAKAGLLFGGEKSSALHTKGKIETRHVAAMEKYKEGLANTREILVDLG 360

Query: 361 LDPTQEDCVATHRICQIVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKH 420
           L+P++ DC+A   +C IVS RSA+LCAA LAA+L R++ENK  ERLR+T+G+DG++YK H
Sbjct: 361 LEPSEADCIAVQHVCTIVSFRSANLCAAALAAILTRLRENKKVERLRTTVGMDGTLYKIH 420

Query: 421 PHFAKRLHKTVRRLVPGCDVRFLRSEDGSGKGAAMVTAVAYRLADQHRARQKTLEHLQLS 480
           P + KRLHK VR+LVP CDVRFL SE GS KGAAMVTAVA R+  Q +   + L   QL+
Sbjct: 421 PQYPKRLHKVVRKLVPSCDVRFLLSESGSTKGAAMVTAVASRVQAQRKQIDRVLALFQLT 480

Query: 481 HDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRV 540
            +QL++V+ +M+ E+E GL K++H  A V+MLPTYVC  PDGTEKG FLALDLGGTNFRV
Sbjct: 481 REQLVDVQAKMRAELEYGLKKKSHGLATVRMLPTYVCGLPDGTEKGKFLALDLGGTNFRV 540

Query: 541 LLVRVRNGKWGGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGF 600
           LLV++R+G+   V M+NKI+AIP E+M GTG+ELFDHIVQCIADFL+YMG+KG SLPLGF
Sbjct: 541 LLVKIRSGR-RSVRMYNKIFAIPLEIMQGTGEELFDHIVQCIADFLDYMGLKGASLPLGF 599

Query: 601 TFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVG 660
           TFSFPC+Q S+D+  L+ WTKGFKA+ CEGEDVV +L+EAI RR EFDLD+VAVVNDTVG
Sbjct: 600 TFSFPCRQMSIDKGTLIGWTKGFKATDCEGEDVVDMLREAIKRRNEFDLDIVAVVNDTVG 659

Query: 661 TMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEGRMCVNMEWGAFGDNGCLDD 720
           TMMTCG+EDP+CE+GLI GTGSN CYME+MRN+E+VEG EG+MC+N EWG FGDNGC+DD
Sbjct: 660 TMMTCGYEDPNCEIGLIAGTGSNMCYMEDMRNIEMVEGGEGKMCINTEWGGFGDNGCIDD 719

Query: 721 FRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRG 780
            RT +D  VDE SLNPGKQR+EKM SGMYLGEIVR ILID TK+GLLFRG+ISERL+TRG
Sbjct: 720 IRTRYDTEVDEGSLNPGKQRYEKMTSGMYLGEIVRQILIDLTKQGLLFRGQISERLRTRG 779

Query: 781 IFETKFLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAA 840
           IFETKFLSQIESD LALLQVR ILQ LGL+STC+DSI+VKEVC  V+RRAAQLCGAG+AA
Sbjct: 780 IFETKFLSQIESDRLALLQVRRILQQLGLDSTCEDSIVVKEVCGAVSRRAAQLCGAGLAA 839

Query: 841 VVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKDLAPKCDVSFLQSEDGSGKG 900
           +V++ RE++GL+ L++TVGVDGTLYKLHPHF++++ ETVK+LAP+CDV+F+ SEDGSGKG
Sbjct: 840 IVEKRREDQGLEHLRITVGVDGTLYKLHPHFSRILQETVKELAPRCDVTFMLSEDGSGKG 899

Query: 901 AALITAVACRIREA 914
           AALITAVA R+++A
Sbjct: 900 AALITAVAKRLQQA 913


>gi|194097330 hexokinase 3 [Homo sapiens]
          Length = 923

 Score = 1013 bits (2620), Expect = 0.0
 Identities = 506/899 (56%), Positives = 658/899 (73%), Gaps = 9/899 (1%)

Query: 17  DQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTE 76
           D  + V + L   +++   L +I       ME+ L     P  AV+MLPT+V STP GTE
Sbjct: 28  DSSELVQECLQQFKVTRAQLQQIQASLLGSMEQALRGQASPAPAVRMLPTYVGSTPHGTE 87

Query: 77  HGEFLALDLG--GTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECL 134
            G+F+ L+LG  G + RVLWV +T     +VE  +Q + IP+++M G+G QLFD  A CL
Sbjct: 88  QGDFVVLELGATGASLRVLWVTLTGIEGHRVEPRSQEFVIPQEVMLGAGQQLFDFAAHCL 147

Query: 135 ANFMDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQ 194
           + F+D   +  + L LGF+FSFPCHQT LD S L+SWTKGF+ SGVEG+DVV L+R AI+
Sbjct: 148 SEFLDAQPVNKQGLQLGFSFSFPCHQTGLDRSTLISWTKGFRCSGVEGQDVVQLLRDAIR 207

Query: 195 RRGDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGR 254
           R+G ++ID+VAVVNDTVGTMM C      CE+GL+V TG+NACYMEE RH+ +++ D GR
Sbjct: 208 RQGAYNIDVVAVVNDTVGTMMGCEPGVRPCEVGLVVDTGTNACYMEEARHVAVLDEDRGR 267

Query: 255 MCINMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMA 314
           +C+++EWG+F DDG+L  + T FD  +D  SLNPG Q FEKMI G+Y+GELVRL+L  +A
Sbjct: 268 VCVSVEWGSFSDDGALGPVLTTFDHTLDHESLNPGAQRFEKMIGGLYLGELVRLVLAHLA 327

Query: 315 KEELLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLGLDPTQEDCVATHRI 374
           +  +LFGG  SP LL+ G    + ++++E    G  +   +L  LGL P   D      +
Sbjct: 328 RCGVLFGGCTSPALLSQGSILLEHVAEMEDPSTGAARVHAILQDLGLSPGASDVELVQHV 387

Query: 375 CQIVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRRL 434
           C  V TR+A LCAA LAAVL  ++ ++ ++ L+  +   G V ++HP F   L  TV  L
Sbjct: 388 CAAVCTRAAQLCAAALAAVLSCLQHSREQQTLQVAVATGGRVCERHPRFCSVLQGTVMLL 447

Query: 435 VPGCDVRFLRSEDGSGKGAAMVTAVAYRLADQHRARQKTLEHLQLSHDQLLEVKRRMKVE 494
            P CDV  + S DG G+G AMVTAVA RLA   R  ++TL   +L+HDQL  V+ +M+  
Sbjct: 448 APECDVSLIPSVDGGGRGVAMVTAVAARLAAHRRLLEETLAPFRLNHDQLAAVQAQMRKA 507

Query: 495 MERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKWGGVE 554
           M +GL  E   ++ ++MLPT+V ATPDG+E+GDFLALDLGGTNFRVLLVRV  G    V+
Sbjct: 508 MAKGLRGE---ASSLRMLPTFVRATPDGSERGDFLALDLGGTNFRVLLVRVTTG----VQ 560

Query: 555 MHNKIYAIPQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNSLDES 614
           + ++IY+IP+ V  G+G +LFDHIV CI DF +  G+ G SLPLGFTFSFPC+Q  LD+ 
Sbjct: 561 ITSEIYSIPETVAQGSGQQLFDHIVDCIVDFQQKQGLSGQSLPLGFTFSFPCRQLGLDQG 620

Query: 615 ILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGFEDPHCEV 674
           ILL WTKGFKAS CEG+DVV+LL+EAI RR+  +L+VVA+VNDTVGTMM+CG+EDP CE+
Sbjct: 621 ILLNWTKGFKASDCEGQDVVSLLREAITRRQAVELNVVAIVNDTVGTMMSCGYEDPRCEI 680

Query: 675 GLIVGTGSNACYMEEMRNVELVEGEEGRMCVNMEWGAFGDNGCLDDFRTEFDVAVDELSL 734
           GLIVGTG+NACYMEE+RNV  V G+ GRMC+NMEWGAFGD+G L    T FD +VD+ S+
Sbjct: 681 GLIVGTGTNACYMEELRNVAGVPGDSGRMCINMEWGAFGDDGSLAMLSTRFDASVDQASI 740

Query: 735 NPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRGIFETKFLSQIESDC 794
           NPGKQRFEKMISGMYLGEIVR+IL+  T  G+LFRG+  +RL+TR IF+TKFLS+IESD 
Sbjct: 741 NPGKQRFEKMISGMYLGEIVRHILLHLTSLGVLFRGQQIQRLQTRDIFKTKFLSEIESDS 800

Query: 795 LALLQVRAILQHLGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAAVVDRIRENRGLDAL 854
           LAL QVRAIL+ LGL  T DD+++V EVC  V++RAAQLCGAG+AAVV++IRENRGL+ L
Sbjct: 801 LALRQVRAILEDLGLPLTSDDALMVLEVCQAVSQRAAQLCGAGVAAVVEKIRENRGLEEL 860

Query: 855 KVTVGVDGTLYKLHPHFAKVMHETVKDLAPKCDVSFLQSEDGSGKGAALITAVACRIRE 913
            V+VGVDGTLYKLHP F+ ++  TV++LAP+C V+FLQSEDGSGKGAAL+TAVACR+ +
Sbjct: 861 AVSVGVDGTLYKLHPRFSSLVAATVRELAPRCVVTFLQSEDGSGKGAALVTAVACRLAQ 919



 Score =  487 bits (1253), Expect = e-137
 Identities = 243/447 (54%), Positives = 323/447 (72%), Gaps = 7/447 (1%)

Query: 22  VDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEFL 81
           +++ L   RL+ + L  +  + RK M KGL       ++++MLPTFVR+TPDG+E G+FL
Sbjct: 483 LEETLAPFRLNHDQLAAVQAQMRKAMAKGLRGEA---SSLRMLPTFVRATPDGSERGDFL 539

Query: 82  ALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDKL 141
           ALDLGGTNFRVL V+VT      V++ ++IY+IPE + +GSG QLFDHI +C+ +F  K 
Sbjct: 540 ALDLGGTNFRVLLVRVTTG----VQITSEIYSIPETVAQGSGQQLFDHIVDCIVDFQQKQ 595

Query: 142 QIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRRGDFDI 201
            +  + LPLGFTFSFPC Q  LD+  L++WTKGFK+S  EG+DVV+L+R+AI RR   ++
Sbjct: 596 GLSGQSLPLGFTFSFPCRQLGLDQGILLNWTKGFKASDCEGQDVVSLLREAITRRQAVEL 655

Query: 202 DIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRMCINMEW 261
           ++VA+VNDTVGTMM+CGY+D  CEIGLIVGTG+NACYMEE+R++  V GD GRMCINMEW
Sbjct: 656 NVVAIVNDTVGTMMSCGYEDPRCEIGLIVGTGTNACYMEELRNVAGVPGDSGRMCINMEW 715

Query: 262 GAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEELLFG 321
           GAFGDDGSL  + T FD  +D  S+NPGKQ FEKMISGMY+GE+VR IL+ +    +LF 
Sbjct: 716 GAFGDDGSLAMLSTRFDASVDQASINPGKQRFEKMISGMYLGEIVRHILLHLTSLGVLFR 775

Query: 322 GKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLGLDPTQEDCVATHRICQIVSTR 381
           G+    L     F+TK +S+IE +   +R+ R +L  LGL  T +D +    +CQ VS R
Sbjct: 776 GQQIQRLQTRDIFKTKFLSEIESDSLALRQVRAILEDLGLPLTSDDALMVLEVCQAVSQR 835

Query: 382 SASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRRLVPGCDVR 441
           +A LC A +AAV+++I+EN+G E L  ++GVDG++YK HP F+  +  TVR L P C V 
Sbjct: 836 AAQLCGAGVAAVVEKIRENRGLEELAVSVGVDGTLYKLHPRFSSLVAATVRELAPRCVVT 895

Query: 442 FLRSEDGSGKGAAMVTAVAYRLADQHR 468
           FL+SEDGSGKGAA+VTAVA RLA   R
Sbjct: 896 FLQSEDGSGKGAALVTAVACRLAQLTR 922



 Score =  396 bits (1017), Expect = e-110
 Identities = 205/450 (45%), Positives = 288/450 (64%), Gaps = 2/450 (0%)

Query: 464 ADQHRARQKTLEHLQLSHDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGT 523
           +D     Q+ L+  +++  QL +++  +   ME+ L  +   +  V+MLPTYV +TP GT
Sbjct: 27  SDSSELVQECLQQFKVTRAQLQQIQASLLGSMEQALRGQASPAPAVRMLPTYVGSTPHGT 86

Query: 524 EKGDFLALDLG--GTNFRVLLVRVRNGKWGGVEMHNKIYAIPQEVMHGTGDELFDHIVQC 581
           E+GDF+ L+LG  G + RVL V +   +   VE  ++ + IPQEVM G G +LFD    C
Sbjct: 87  EQGDFVVLELGATGASLRVLWVTLTGIEGHRVEPRSQEFVIPQEVMLGAGQQLFDFAAHC 146

Query: 582 IADFLEYMGMKGVSLPLGFTFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAI 641
           +++FL+   +    L LGF+FSFPC Q  LD S L+ WTKGF+ SG EG+DVV LL++AI
Sbjct: 147 LSEFLDAQPVNKQGLQLGFSFSFPCHQTGLDRSTLISWTKGFRCSGVEGQDVVQLLRDAI 206

Query: 642 HRREEFDLDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEG 701
            R+  +++DVVAVVNDTVGTMM C      CEVGL+V TG+NACYMEE R+V +++ + G
Sbjct: 207 RRQGAYNIDVVAVVNDTVGTMMGCEPGVRPCEVGLVVDTGTNACYMEEARHVAVLDEDRG 266

Query: 702 RMCVNMEWGAFGDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDF 761
           R+CV++EWG+F D+G L    T FD  +D  SLNPG QRFEKMI G+YLGE+VR +L   
Sbjct: 267 RVCVSVEWGSFSDDGALGPVLTTFDHTLDHESLNPGAQRFEKMIGGLYLGELVRLVLAHL 326

Query: 762 TKRGLLFRGRISERLKTRGIFETKFLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKE 821
            + G+LF G  S  L ++G    + ++++E       +V AILQ LGL     D  +V+ 
Sbjct: 327 ARCGVLFGGCTSPALLSQGSILLEHVAEMEDPSTGAARVHAILQDLGLSPGASDVELVQH 386

Query: 822 VCTVVARRAAQLCGAGMAAVVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKD 881
           VC  V  RAAQLC A +AAV+  ++ +R    L+V V   G + + HP F  V+  TV  
Sbjct: 387 VCAAVCTRAAQLCAAALAAVLSCLQHSREQQTLQVAVATGGRVCERHPRFCSVLQGTVML 446

Query: 882 LAPKCDVSFLQSEDGSGKGAALITAVACRI 911
           LAP+CDVS + S DG G+G A++TAVA R+
Sbjct: 447 LAPECDVSLIPSVDGGGRGVAMVTAVAARL 476


>gi|4503951 glucokinase isoform 1 [Homo sapiens]
          Length = 465

 Score =  520 bits (1340), Expect = e-147
 Identities = 242/447 (54%), Positives = 340/447 (76%), Gaps = 2/447 (0%)

Query: 20  QKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGE 79
           +KV+Q L   +L +E L ++ +R +KEM++GL   TH  A+VKMLPT+VRSTP+G+E G+
Sbjct: 14  EKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGD 73

Query: 80  FLALDLGGTNFRVLWVKVTDN--GLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLANF 137
           FL+LDLGGTNFRV+ VKV +   G   V+ ++Q+Y+IPED M G+   LFD+I+EC+++F
Sbjct: 74  FLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDF 133

Query: 138 MDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRRG 197
           +DK Q+K KKLPLGFTFSFP     +D+  L++WTKGFK+SG EG +VV L+R AI+RRG
Sbjct: 134 LDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRG 193

Query: 198 DFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRMCI 257
           DF++D+VA+VNDTV TM++C Y+DH CE+G+IVGTG NACYMEEM+++++VEGDEGRMC+
Sbjct: 194 DFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCV 253

Query: 258 NMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEE 317
           N EWGAFGD G L++   E+D+ +D  S NPG+QL+EK+I G YMGELVRL+L+++  E 
Sbjct: 254 NTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDEN 313

Query: 318 LLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLGLDPTQEDCVATHRICQI 377
           LLF G+ S +L   G FET+ +S +E +    ++   +L  LGL P+  DC    R C+ 
Sbjct: 314 LLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACES 373

Query: 378 VSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRRLVPG 437
           VSTR+A +C+A LA V+ R++E++ E+ +R T+GVDGSVYK HP F +R H +VRRL P 
Sbjct: 374 VSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPS 433

Query: 438 CDVRFLRSEDGSGKGAAMVTAVAYRLA 464
           C++ F+ SE+GSG+GAA+V+AVA + A
Sbjct: 434 CEITFIESEEGSGRGAALVSAVACKKA 460



 Score =  516 bits (1329), Expect = e-146
 Identities = 250/442 (56%), Positives = 334/442 (75%), Gaps = 2/442 (0%)

Query: 471 QKTLEHLQLSHDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLA 530
           ++ L   QL  + L +V RRM+ EM+RGL  ETH  A VKMLPTYV +TP+G+E GDFL+
Sbjct: 17  EQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLS 76

Query: 531 LDLGGTNFRVLLVRVRNGKWG--GVEMHNKIYAIPQEVMHGTGDELFDHIVQCIADFLEY 588
           LDLGGTNFRV+LV+V  G+ G   V+  +++Y+IP++ M GT + LFD+I +CI+DFL+ 
Sbjct: 77  LDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDK 136

Query: 589 MGMKGVSLPLGFTFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFD 648
             MK   LPLGFTFSFP +   +D+ ILL WTKGFKASG EG +VV LL++AI RR +F+
Sbjct: 137 HQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFE 196

Query: 649 LDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEGRMCVNME 708
           +DVVA+VNDTV TM++C +ED  CEVG+IVGTG NACYMEEM+NVELVEG+EGRMCVN E
Sbjct: 197 MDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTE 256

Query: 709 WGAFGDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLF 768
           WGAFGD+G LD+F  E+D  VDE S NPG+Q +EK+I G Y+GE+VR +L+      LLF
Sbjct: 257 WGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLF 316

Query: 769 RGRISERLKTRGIFETKFLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVCTVVAR 828
            G  SE+L+TRG FET+F+SQ+ESD     Q+  IL  LGL  +  D  IV+  C  V+ 
Sbjct: 317 HGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVST 376

Query: 829 RAAQLCGAGMAAVVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKDLAPKCDV 888
           RAA +C AG+A V++R+RE+R  D +++TVGVDG++YKLHP F +  H +V+ L P C++
Sbjct: 377 RAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEI 436

Query: 889 SFLQSEDGSGKGAALITAVACR 910
           +F++SE+GSG+GAAL++AVAC+
Sbjct: 437 TFIESEEGSGRGAALVSAVACK 458


>gi|15967161 glucokinase isoform 3 [Homo sapiens]
          Length = 464

 Score =  518 bits (1334), Expect = e-146
 Identities = 241/446 (54%), Positives = 339/446 (76%), Gaps = 2/446 (0%)

Query: 21  KVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEF 80
           +V+Q L   +L +E L ++ +R +KEM++GL   TH  A+VKMLPT+VRSTP+G+E G+F
Sbjct: 14  QVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDF 73

Query: 81  LALDLGGTNFRVLWVKVTDN--GLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLANFM 138
           L+LDLGGTNFRV+ VKV +   G   V+ ++Q+Y+IPED M G+   LFD+I+EC+++F+
Sbjct: 74  LSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFL 133

Query: 139 DKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRRGD 198
           DK Q+K KKLPLGFTFSFP     +D+  L++WTKGFK+SG EG +VV L+R AI+RRGD
Sbjct: 134 DKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGD 193

Query: 199 FDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRMCIN 258
           F++D+VA+VNDTV TM++C Y+DH CE+G+IVGTG NACYMEEM+++++VEGDEGRMC+N
Sbjct: 194 FEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVN 253

Query: 259 MEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEEL 318
            EWGAFGD G L++   E+D+ +D  S NPG+QL+EK+I G YMGELVRL+L+++  E L
Sbjct: 254 TEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENL 313

Query: 319 LFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLGLDPTQEDCVATHRICQIV 378
           LF G+ S +L   G FET+ +S +E +    ++   +L  LGL P+  DC    R C+ V
Sbjct: 314 LFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESV 373

Query: 379 STRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRRLVPGC 438
           STR+A +C+A LA V+ R++E++ E+ +R T+GVDGSVYK HP F +R H +VRRL P C
Sbjct: 374 STRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSC 433

Query: 439 DVRFLRSEDGSGKGAAMVTAVAYRLA 464
           ++ F+ SE+GSG+GAA+V+AVA + A
Sbjct: 434 EITFIESEEGSGRGAALVSAVACKKA 459



 Score =  516 bits (1329), Expect = e-146
 Identities = 250/442 (56%), Positives = 334/442 (75%), Gaps = 2/442 (0%)

Query: 471 QKTLEHLQLSHDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLA 530
           ++ L   QL  + L +V RRM+ EM+RGL  ETH  A VKMLPTYV +TP+G+E GDFL+
Sbjct: 16  EQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLS 75

Query: 531 LDLGGTNFRVLLVRVRNGKWG--GVEMHNKIYAIPQEVMHGTGDELFDHIVQCIADFLEY 588
           LDLGGTNFRV+LV+V  G+ G   V+  +++Y+IP++ M GT + LFD+I +CI+DFL+ 
Sbjct: 76  LDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDK 135

Query: 589 MGMKGVSLPLGFTFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFD 648
             MK   LPLGFTFSFP +   +D+ ILL WTKGFKASG EG +VV LL++AI RR +F+
Sbjct: 136 HQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFE 195

Query: 649 LDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEGRMCVNME 708
           +DVVA+VNDTV TM++C +ED  CEVG+IVGTG NACYMEEM+NVELVEG+EGRMCVN E
Sbjct: 196 MDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTE 255

Query: 709 WGAFGDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLF 768
           WGAFGD+G LD+F  E+D  VDE S NPG+Q +EK+I G Y+GE+VR +L+      LLF
Sbjct: 256 WGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLF 315

Query: 769 RGRISERLKTRGIFETKFLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVCTVVAR 828
            G  SE+L+TRG FET+F+SQ+ESD     Q+  IL  LGL  +  D  IV+  C  V+ 
Sbjct: 316 HGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVST 375

Query: 829 RAAQLCGAGMAAVVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKDLAPKCDV 888
           RAA +C AG+A V++R+RE+R  D +++TVGVDG++YKLHP F +  H +V+ L P C++
Sbjct: 376 RAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEI 435

Query: 889 SFLQSEDGSGKGAALITAVACR 910
           +F++SE+GSG+GAAL++AVAC+
Sbjct: 436 TFIESEEGSGRGAALVSAVACK 457


>gi|15967159 glucokinase isoform 2 [Homo sapiens]
          Length = 466

 Score =  518 bits (1333), Expect = e-146
 Identities = 241/445 (54%), Positives = 338/445 (75%), Gaps = 2/445 (0%)

Query: 22  VDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEFL 81
           V+Q L   +L +E L ++ +R +KEM++GL   TH  A+VKMLPT+VRSTP+G+E G+FL
Sbjct: 17  VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFL 76

Query: 82  ALDLGGTNFRVLWVKVTDN--GLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMD 139
           +LDLGGTNFRV+ VKV +   G   V+ ++Q+Y+IPED M G+   LFD+I+EC+++F+D
Sbjct: 77  SLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLD 136

Query: 140 KLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRRGDF 199
           K Q+K KKLPLGFTFSFP     +D+  L++WTKGFK+SG EG +VV L+R AI+RRGDF
Sbjct: 137 KHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDF 196

Query: 200 DIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRMCINM 259
           ++D+VA+VNDTV TM++C Y+DH CE+G+IVGTG NACYMEEM+++++VEGDEGRMC+N 
Sbjct: 197 EMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNT 256

Query: 260 EWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEELL 319
           EWGAFGD G L++   E+D+ +D  S NPG+QL+EK+I G YMGELVRL+L+++  E LL
Sbjct: 257 EWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLL 316

Query: 320 FGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLGLDPTQEDCVATHRICQIVS 379
           F G+ S +L   G FET+ +S +E +    ++   +L  LGL P+  DC    R C+ VS
Sbjct: 317 FHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVS 376

Query: 380 TRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRRLVPGCD 439
           TR+A +C+A LA V+ R++E++ E+ +R T+GVDGSVYK HP F +R H +VRRL P C+
Sbjct: 377 TRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCE 436

Query: 440 VRFLRSEDGSGKGAAMVTAVAYRLA 464
           + F+ SE+GSG+GAA+V+AVA + A
Sbjct: 437 ITFIESEEGSGRGAALVSAVACKKA 461



 Score =  516 bits (1329), Expect = e-146
 Identities = 250/442 (56%), Positives = 334/442 (75%), Gaps = 2/442 (0%)

Query: 471 QKTLEHLQLSHDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLA 530
           ++ L   QL  + L +V RRM+ EM+RGL  ETH  A VKMLPTYV +TP+G+E GDFL+
Sbjct: 18  EQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLS 77

Query: 531 LDLGGTNFRVLLVRVRNGKWG--GVEMHNKIYAIPQEVMHGTGDELFDHIVQCIADFLEY 588
           LDLGGTNFRV+LV+V  G+ G   V+  +++Y+IP++ M GT + LFD+I +CI+DFL+ 
Sbjct: 78  LDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDK 137

Query: 589 MGMKGVSLPLGFTFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFD 648
             MK   LPLGFTFSFP +   +D+ ILL WTKGFKASG EG +VV LL++AI RR +F+
Sbjct: 138 HQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFE 197

Query: 649 LDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEGRMCVNME 708
           +DVVA+VNDTV TM++C +ED  CEVG+IVGTG NACYMEEM+NVELVEG+EGRMCVN E
Sbjct: 198 MDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTE 257

Query: 709 WGAFGDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLF 768
           WGAFGD+G LD+F  E+D  VDE S NPG+Q +EK+I G Y+GE+VR +L+      LLF
Sbjct: 258 WGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLF 317

Query: 769 RGRISERLKTRGIFETKFLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVCTVVAR 828
            G  SE+L+TRG FET+F+SQ+ESD     Q+  IL  LGL  +  D  IV+  C  V+ 
Sbjct: 318 HGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVST 377

Query: 829 RAAQLCGAGMAAVVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKDLAPKCDV 888
           RAA +C AG+A V++R+RE+R  D +++TVGVDG++YKLHP F +  H +V+ L P C++
Sbjct: 378 RAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEI 437

Query: 889 SFLQSEDGSGKGAALITAVACR 910
           +F++SE+GSG+GAAL++AVAC+
Sbjct: 438 TFIESEEGSGRGAALVSAVACK 459


>gi|134254462 ribosomal modification protein rimK-like family member
           B [Homo sapiens]
          Length = 386

 Score = 33.1 bits (74), Expect = 1.2
 Identities = 39/170 (22%), Positives = 64/170 (37%), Gaps = 45/170 (26%)

Query: 130 IAECLANFMDKLQIKDKKLPLGFTFSFPCHQT---KLDES------FLVSWTKGFKSSGV 180
           I  C+  F    ++    +PL  TFS+  H+     +DE+       +V  T+G +   V
Sbjct: 109 ILNCVNKFWTFQELAGHGVPLPDTFSYGGHENFAKMIDEAEVLEFPMVVKNTRGHRGKAV 168

Query: 181 -------EGRDVVALIR--------KAIQRRGDFDIDIVAVVNDTVGTMMTCGYD---DH 222
                     D+  LIR        K ++     D+ ++ V    VGTM+ C  D     
Sbjct: 169 FLARDKHHLADLSHLIRHEAPYLFQKYVKESHGRDVRVIVVGGRVVGTMLRCSTDGRMQS 228

Query: 223 NCEIGLIVGTGSNACYMEEMRH---------------IDMVEGDEGRMCI 257
           NC +G   G G      E+ +                ID++  D+G  C+
Sbjct: 229 NCSLG---GVGMMCSLSEQGKQLAIQVSNILGMDVCGIDLLMKDDGSFCV 275


>gi|50658079 tubulin tyrosine ligase-like family, member 5 [Homo
            sapiens]
          Length = 1281

 Score = 32.7 bits (73), Expect = 1.6
 Identities = 32/122 (26%), Positives = 55/122 (45%), Gaps = 11/122 (9%)

Query: 454  AMVTAVAYRLADQHRARQKTLEHLQLSHDQLLEVKRRMKVEMERGLSKETHASAPVKMLP 513
            +MVTA   RLA++  ARQ    +   SH  LL  ++   + +  G+   + ASAP  + P
Sbjct: 1027 SMVTAELQRLAEKQAARQ----YSPSSHINLL-TQQVTNLNLATGIINRSSASAPPTLRP 1081

Query: 514  TYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKWGGVEMHNKIYA-----IPQEVMH 568
                + P  + + D  A +   ++     ++     W G E+ N +Y+     +PQ   H
Sbjct: 1082 IISPSGPTWSTQSDPQAPENHSSSPGSRSLQTGGFAWEG-EVENNVYSQATGVVPQHKYH 1140

Query: 569  GT 570
             T
Sbjct: 1141 PT 1142


>gi|164663810 ribosomal modification protein rimK-like family member
           A [Homo sapiens]
          Length = 391

 Score = 32.0 bits (71), Expect = 2.7
 Identities = 29/125 (23%), Positives = 49/125 (39%), Gaps = 27/125 (21%)

Query: 130 IAECLANFMDKLQIKDKKLPLGFTFSFPCHQT---KLDES------FLVSWTKGFKSSGV 180
           I  C+  F    ++    +P+  TFS+  H+     +DE+       +V  T+G +   V
Sbjct: 105 ILNCINKFWTFQELAGHGVPMPDTFSYGGHEDFSKMIDEAEPLGYPVVVKSTRGHRGKAV 164

Query: 181 E---------------GRDVVALIRKAIQRRGDFDIDIVAVVNDTVGTMMTCGYD---DH 222
                             DV  L +K ++     DI +V V    +G+M+ C  D     
Sbjct: 165 FLARDKHHLSDICHLIRHDVPYLFQKYVKESHGKDIRVVVVGGQVIGSMLRCSTDGRMQS 224

Query: 223 NCEIG 227
           NC +G
Sbjct: 225 NCSLG 229


>gi|65301164 very low density lipoprotein receptor isoform b [Homo
           sapiens]
          Length = 845

 Score = 30.4 bits (67), Expect = 7.9
 Identities = 15/49 (30%), Positives = 20/49 (40%), Gaps = 2/49 (4%)

Query: 669 DPHCEVGLIVGTGSNACYMEEMRNVELVEGEEGRMCVNMEWGAFGDNGC 717
           DP CE G         C+M   R  E+  G     C+ + W   G+N C
Sbjct: 94  DPDCEDGS--DESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDC 140


>gi|65301167 very low density lipoprotein receptor isoform a [Homo
           sapiens]
          Length = 873

 Score = 30.4 bits (67), Expect = 7.9
 Identities = 15/49 (30%), Positives = 20/49 (40%), Gaps = 2/49 (4%)

Query: 669 DPHCEVGLIVGTGSNACYMEEMRNVELVEGEEGRMCVNMEWGAFGDNGC 717
           DP CE G         C+M   R  E+  G     C+ + W   G+N C
Sbjct: 94  DPDCEDGS--DESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDC 140


>gi|51093830 bicaudal D homolog 1 isoform 2 [Homo sapiens]
          Length = 835

 Score = 30.4 bits (67), Expect = 7.9
 Identities = 31/145 (21%), Positives = 60/145 (41%), Gaps = 6/145 (4%)

Query: 11  FTELNHDQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRS 70
           F+ELN  ++QK+ Q L  +      LL   +  + ++E   GA T     V  L   V +
Sbjct: 318 FSELNISEIQKLKQQLMQVEREKAILLANLQESQTQLEHTKGALTEQHERVHRLTEHVNA 377

Query: 71  TPDGTEHGEFLALDLGGTNFRVLWVKVTD-----NGLQKVEMENQIYAIPEDIMRGSGTQ 125
              G +  + L  +L G   R    +  D     NGL+ +E + ++       ++     
Sbjct: 378 M-RGLQSSKELKAELDGEKGRDSGEEAHDYEVDINGLEILECKYRVAVTEVIDLKAEIKA 436

Query: 126 LFDHIAECLANFMDKLQIKDKKLPL 150
           L +   + + N+ D+    + K+ +
Sbjct: 437 LKEKYNKSVENYTDEKAKYESKIQM 461


>gi|51039802 bicaudal D homolog 1 isoform 1 [Homo sapiens]
          Length = 975

 Score = 30.4 bits (67), Expect = 7.9
 Identities = 31/145 (21%), Positives = 60/145 (41%), Gaps = 6/145 (4%)

Query: 11  FTELNHDQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRS 70
           F+ELN  ++QK+ Q L  +      LL   +  + ++E   GA T     V  L   V +
Sbjct: 318 FSELNISEIQKLKQQLMQVEREKAILLANLQESQTQLEHTKGALTEQHERVHRLTEHVNA 377

Query: 71  TPDGTEHGEFLALDLGGTNFRVLWVKVTD-----NGLQKVEMENQIYAIPEDIMRGSGTQ 125
              G +  + L  +L G   R    +  D     NGL+ +E + ++       ++     
Sbjct: 378 M-RGLQSSKELKAELDGEKGRDSGEEAHDYEVDINGLEILECKYRVAVTEVIDLKAEIKA 436

Query: 126 LFDHIAECLANFMDKLQIKDKKLPL 150
           L +   + + N+ D+    + K+ +
Sbjct: 437 LKEKYNKSVENYTDEKAKYESKIQM 461


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.138    0.409 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,464,434
Number of Sequences: 37866
Number of extensions: 1479327
Number of successful extensions: 2926
Number of sequences better than 10.0: 18
Number of HSP's better than 10.0 without gapping: 11
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 2878
Number of HSP's gapped (non-prelim): 38
length of query: 917
length of database: 18,247,518
effective HSP length: 111
effective length of query: 806
effective length of database: 14,044,392
effective search space: 11319779952
effective search space used: 11319779952
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.