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Search of human proteins with 154354985
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|154354985 hook homolog 2 isoform 1 [Homo sapiens]
(719 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|154354985 hook homolog 2 isoform 1 [Homo sapiens] 1405 0.0
gi|154354987 hook homolog 2 isoform 2 [Homo sapiens] 1397 0.0
gi|14165274 golgi-associated microtubule-binding protein HOOK3 [... 676 0.0
gi|7705415 hook homolog 1 [Homo sapiens] 639 0.0
gi|148762940 DVL-binding protein DAPLE [Homo sapiens] 134 4e-31
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 130 3e-30
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 130 3e-30
gi|16262452 cingulin [Homo sapiens] 102 1e-21
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 101 3e-21
gi|21735548 centrosomal protein 2 [Homo sapiens] 101 3e-21
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 96 1e-19
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 96 1e-19
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 96 1e-19
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 96 1e-19
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 96 1e-19
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 96 1e-19
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 96 1e-19
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 96 1e-19
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 95 2e-19
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 95 2e-19
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 95 2e-19
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 95 3e-19
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 91 4e-18
gi|148746195 trichohyalin [Homo sapiens] 91 5e-18
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 90 8e-18
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 89 1e-17
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 89 1e-17
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 89 1e-17
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 89 1e-17
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 88 2e-17
>gi|154354985 hook homolog 2 isoform 1 [Homo sapiens]
Length = 719
Score = 1405 bits (3638), Expect = 0.0
Identities = 719/719 (100%), Positives = 719/719 (100%)
Query: 1 MSVDKAELCGSLLTWLQTFHVPSPCASPQDLSSGLAVAYVLNQIDPSWFNEAWLQGISED 60
MSVDKAELCGSLLTWLQTFHVPSPCASPQDLSSGLAVAYVLNQIDPSWFNEAWLQGISED
Sbjct: 1 MSVDKAELCGSLLTWLQTFHVPSPCASPQDLSSGLAVAYVLNQIDPSWFNEAWLQGISED 60
Query: 61 PGPNWKLKVSNLKMVLRSLVEYSQDVLAHPVSEEHLPDVSLIGEFSDPAELGKLLQLVLG 120
PGPNWKLKVSNLKMVLRSLVEYSQDVLAHPVSEEHLPDVSLIGEFSDPAELGKLLQLVLG
Sbjct: 61 PGPNWKLKVSNLKMVLRSLVEYSQDVLAHPVSEEHLPDVSLIGEFSDPAELGKLLQLVLG 120
Query: 121 CAISCEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYFL 180
CAISCEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYFL
Sbjct: 121 CAISCEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYFL 180
Query: 181 SEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLL 240
SEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLL
Sbjct: 181 SEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLL 240
Query: 241 LQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDEL 300
LQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDEL
Sbjct: 241 LQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDEL 300
Query: 301 RQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRA 360
RQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRA
Sbjct: 301 RQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRA 360
Query: 361 QLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEE 420
QLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEE
Sbjct: 361 QLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEE 420
Query: 421 LRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQEAADRE 480
LRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQEAADRE
Sbjct: 421 LRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQEAADRE 480
Query: 481 RQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDAISILLK 540
RQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDAISILLK
Sbjct: 481 RQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDAISILLK 540
Query: 541 RKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERY 600
RKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERY
Sbjct: 541 RKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERY 600
Query: 601 RRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEE 660
RRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEE
Sbjct: 601 RRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEE 660
Query: 661 KLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQRLATNSRRGPLGRLASLNLRPTDKH 719
KLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQRLATNSRRGPLGRLASLNLRPTDKH
Sbjct: 661 KLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQRLATNSRRGPLGRLASLNLRPTDKH 719
>gi|154354987 hook homolog 2 isoform 2 [Homo sapiens]
Length = 717
Score = 1397 bits (3617), Expect = 0.0
Identities = 717/719 (99%), Positives = 717/719 (99%), Gaps = 2/719 (0%)
Query: 1 MSVDKAELCGSLLTWLQTFHVPSPCASPQDLSSGLAVAYVLNQIDPSWFNEAWLQGISED 60
MSVDKAELCGSLLTWLQTFHVPSPCASPQDLSSGLAVAYVLNQIDPSWFNEAWLQGISED
Sbjct: 1 MSVDKAELCGSLLTWLQTFHVPSPCASPQDLSSGLAVAYVLNQIDPSWFNEAWLQGISED 60
Query: 61 PGPNWKLKVSNLKMVLRSLVEYSQDVLAHPVSEEHLPDVSLIGEFSDPAELGKLLQLVLG 120
PGPNWKLKVSNLKMVLRSLVEYSQDVLAHPVSEEHLPDVSLIGEFSDPAELGKLLQLVLG
Sbjct: 61 PGPNWKLKVSNLKMVLRSLVEYSQDVLAHPVSEEHLPDVSLIGEFSDPAELGKLLQLVLG 120
Query: 121 CAISCEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYFL 180
CAISCEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYFL
Sbjct: 121 CAISCEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYFL 180
Query: 181 SEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLL 240
SEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLL
Sbjct: 181 SEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLL 240
Query: 241 LQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDEL 300
LQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDEL
Sbjct: 241 LQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDEL 300
Query: 301 RQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRA 360
RQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRA
Sbjct: 301 RQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRA 360
Query: 361 QLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEE 420
QLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEE
Sbjct: 361 QLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEE 420
Query: 421 LRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQEAADRE 480
LRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQEAADRE
Sbjct: 421 LRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQEAADRE 480
Query: 481 RQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDAISILLK 540
RQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTED SILLK
Sbjct: 481 RQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTED--SILLK 538
Query: 541 RKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERY 600
RKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERY
Sbjct: 539 RKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERY 598
Query: 601 RRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEE 660
RRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEE
Sbjct: 599 RRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEE 658
Query: 661 KLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQRLATNSRRGPLGRLASLNLRPTDKH 719
KLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQRLATNSRRGPLGRLASLNLRPTDKH
Sbjct: 659 KLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQRLATNSRRGPLGRLASLNLRPTDKH 717
>gi|14165274 golgi-associated microtubule-binding protein HOOK3
[Homo sapiens]
Length = 718
Score = 676 bits (1743), Expect = 0.0
Identities = 359/718 (50%), Positives = 517/718 (72%), Gaps = 10/718 (1%)
Query: 2 SVDKAELCGSLLTWLQTFHVPSPCASPQDLSSGLAVAYVLNQIDPSWFNEAWLQGISEDP 61
S+++AELC SLLTW+QTF+V +PC + +DL++G+ +A VL +IDP++F+E WL I +
Sbjct: 6 SLERAELCESLLTWIQTFNVDAPCQTVEDLTNGVVMAQVLQKIDPAYFDENWLNRIKTEV 65
Query: 62 GPNWKLKVSNLKMVLRSLVEYSQDVLAHPVSEEHLPDVSLIGEFSDPAELGKLLQLVLGC 121
G NW+LK+SNLK +L+ +++Y+ ++L +++ LPDV+LIGE SD AELG++LQL+LGC
Sbjct: 66 GDNWRLKISNLKKILKGILDYNHEILGQQINDFTLPDVNLIGEHSDAAELGRMLQLILGC 125
Query: 122 AISCEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRR-YYFL 180
A++CE+KQ++IQ IM +EESVQHVVM AIQELM+K++P S + Y + D Q ++ L
Sbjct: 126 AVNCEQKQEYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEEL 185
Query: 181 SEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTA-KKLL 239
+E +E+ QRC +L+ Q+ L EEK SL EN L ER+ + + P A ++ L
Sbjct: 186 NEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSDSIEDPNSPAGRRHL 245
Query: 240 LLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDE 299
LQ+QLEQLQEE FRLE+ ++D R+RC ELE+E++EL+ +N LT+LA EAQ+LKDE+D
Sbjct: 246 QLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADEAQSLKDEIDV 305
Query: 300 LRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLR 359
LR SS++ +LE + S +++L +L +LRRQV+ LEE+N + + T LE+ELR+A + R
Sbjct: 306 LRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAAR 365
Query: 360 AQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANE 419
+QLE +RQV ELQ + EE+ KA+K FE + L+EK +S+ KEK+RL ERDSL+E E
Sbjct: 366 SQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRLRTERDSLKETIE 425
Query: 420 ELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRL-CRQEAAD 478
ELRC Q Q LT + D+LAAEI+ E+RE L+RLQ ENK L QE +D
Sbjct: 426 ELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEGSD 485
Query: 479 RERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDAISIL 538
E+ LQ L+DAN ++ LET++RL Q+L E+++QVE+LQK+LQ+QG K ED S+L
Sbjct: 486 NEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAED--SVL 543
Query: 539 LKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEE 598
LK+KLEEHL+KLHEA+ ELQ+KR IE+LEP ++S+ +IEELQ L+KK+ +++ MEE
Sbjct: 544 LKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSL-KIEELQEALRKKEEEMKQMEE 602
Query: 599 RYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQ 658
RY++Y++KA+ V++T++PKQ GA PE+ +L+ QL+ERD LE ++EK++SQRE
Sbjct: 603 RYKKYLEKAKSVIRTLDPKQN--QGAAPEIQALKNQLQERDRLFHSLEKEYEKTKSQREM 660
Query: 659 EEKLLISAWYNMGMALQQRAGEER--APAHAQSFLAQQRLATNSRRGPLGRLASLNLR 714
EEK ++SAWYNMGM L ++A E+R + QSFLA+QR AT+SRR G + R
Sbjct: 661 EEKYIVSAWYNMGMTLHKKAAEDRLASTGSGQSFLARQRQATSSRRSYPGHVQPATAR 718
>gi|7705415 hook homolog 1 [Homo sapiens]
Length = 728
Score = 639 bits (1647), Expect = 0.0
Identities = 347/714 (48%), Positives = 488/714 (68%), Gaps = 24/714 (3%)
Query: 5 KAELCGSLLTWLQTFHVPSPCASPQDLSSGLAVAYVLNQIDPSWFNEAWLQGISEDPGPN 64
K LC SL+ WLQTF+ SPC + L+SG+A+A VL+QID +WFNE+WL I ED G N
Sbjct: 11 KLPLCDSLMIWLQTFNTASPCQDVKQLTSGVAMAQVLHQIDAAWFNESWLSRIKEDVGDN 70
Query: 65 WKLKVSNLKMVLRSLVEYSQDVLAHPVSEEHLPDVSLIGEFSDPAELGKLLQLVLGCAIS 124
W++K SN+K VL+ ++ Y + L +SE +PD++ I E SDP ELG+LLQL+LGCAI+
Sbjct: 71 WRIKASNVKKVLQGIMSYYHEFLGQQISEALIPDLNQITECSDPVELGRLLQLILGCAIN 130
Query: 125 CEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYF-LSEE 183
CEKKQ+HIQ IMTLEESVQHVVM AIQELM+K+ S + G + Q +R L E
Sbjct: 131 CEKKQEHIQNIMTLEESVQHVVMTAIQELMSKEILSSPPNDAVGELEQQLKRALEELQEA 190
Query: 184 AEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEG--EGTPGLTAKKLLLL 241
E +EL+QRC +L+ Q+ L +EK SL EN + E++ + +G + + AKK
Sbjct: 191 LAEKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSFDDPNTVVAKKYFHA 250
Query: 242 QSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDELR 301
Q QLEQLQEENFRLE+ ++D R+ C ELE+++ E QHRN LTSLA+E +ALKDE+D LR
Sbjct: 251 QLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDELTSLAEETRALKDEIDVLR 310
Query: 302 QSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRAQ 361
+S++A +LE+T+ R++L +L +LR+QV+ L+E N + T LE+EL++A + R Q
Sbjct: 311 ATSDKANKLESTVEIYRQKLQDLNDLRKQVKTLQETNMMYMHNTVSLEEELKKANAARTQ 370
Query: 362 LEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEEL 421
LE +RQVQ+L + E+ +A+ FE + LEEK+E++ KEKERL+ +RD+L+E NEEL
Sbjct: 371 LETYKRQVQDLHVKLSSESKRADTLAFEMKRLEEKHEALLKEKERLIEQRDTLKETNEEL 430
Query: 422 RCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRL-CRQEAADRE 480
RC+Q+Q L Q D S + +NLAAEI+P E RE +RLQ ENK L +QE ++ E
Sbjct: 431 RCSQVQQDHLNQTDAS---ATKSYENLAAEIMPVEYREVFIRLQHENKMLRLQQEGSENE 487
Query: 481 RQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDAISILLK 540
R EELQ LE +R + LET+ RL+++++ EL+ Q+EDLQK+LQEQG K+E S LK
Sbjct: 488 RIEELQEQLEQKHRKMNELETEQRLSKERIRELQQQIEDLQKSLQEQGSKSEGESSSKLK 547
Query: 541 RKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERY 600
+KLE H++KL E ELQ+K+E IE+L+P + + ++I EL+ LQKKD D++AMEERY
Sbjct: 548 QKLEAHMEKLTEVHEELQKKQELIEDLQPDINQN-VQKINELEAALQKKDEDMKAMEERY 606
Query: 601 RRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEE 660
+ Y++KAR V++T++PK PA+ E+ LR QL E++ RI LE + + ++ R+ EE
Sbjct: 607 KMYLEKARNVIKTLDPKLNPASA---EIMLLRKQLAEKERRIEILESECKVAKF-RDYEE 662
Query: 661 KLLISAWYNMGMALQQRAGEER------------APAHAQSFLAQQRLATNSRR 702
KL++SAWYN +A Q+ E R A A+SFLAQQR TN+RR
Sbjct: 663 KLIVSAWYNKSLAFQKLGMESRLVSGGGACSDTGACTPARSFLAQQRHITNTRR 716
>gi|148762940 DVL-binding protein DAPLE [Homo sapiens]
Length = 2028
Score = 134 bits (336), Expect = 4e-31
Identities = 191/776 (24%), Positives = 320/776 (41%), Gaps = 180/776 (23%)
Query: 12 LLTWLQTFHVPSPCASPQ------DLSSGLAVAYVLNQIDPSWFNEAWLQGISEDPGPNW 65
L+TW++TF P S DL G+ + ++ QIDP N+ + ++ D
Sbjct: 17 LVTWVKTFG-PFGSGSQDNLTMYMDLVDGIFLNQIMLQIDPRPTNQRINKHVNNDVN--- 72
Query: 66 KLKVSNLKMVLRSLVEYSQDVLAHPVSEEHLPDVSLIGEFSDPA------ELGKLLQLVL 119
L++ NL +++R++ Y Q+VL + +LP+V +IG DP E+ K+L LVL
Sbjct: 73 -LRIQNLTILVRNIKTYYQEVLQQLIVM-NLPNVLMIGR--DPLSGKSMEEIKKVLLLVL 128
Query: 120 GCAISCEKKQDHIQRIMTLEESVQHVVMEAIQE----------LMTKDTPDSLSPETYGN 169
GCA+ CE+K++ I+RI L+ Q ++ IQE L + PD ++PE
Sbjct: 129 GCAVQCERKEEFIERIKQLDIETQAGIVAHIQEVTHNQENVFDLQWLELPD-VAPE---E 184
Query: 170 FDSQSRRYYF-LSEEAEEGDELQQRCLDL--ERQLM-----------------------L 203
++ SR L ++ DE + +DL ER + L
Sbjct: 185 LEALSRSMVLHLRRLIDQRDECTELIVDLTQERDYLQAQHPPSPIKSSSADSTPSPTSSL 244
Query: 204 LSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQSQLEQLQEENFRLESGREDER 263
SE+KQ LA E A + R+ R E L+ + EQL D R
Sbjct: 245 SSEDKQHLAVELADTKARLRRVRQE------------LEDKTEQLV-----------DTR 281
Query: 264 LRCAELEREVAELQHRNQALTSLAQEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGE 323
+L E+ +++ N L + A+ A+A +DE+D LR+ + R +LE LT C+ +L +
Sbjct: 282 HEVDQLVLELQKVKQENIQLAADARSARAYRDELDSLREKANRVERLELELTRCKEKLHD 341
Query: 324 LRELRRQVRQLEERNAGHAERTRQLEDEL---RRAGSLRAQLEAQRRQVQ----ELQGQR 376
+ + ++ +L E N E LE++L R G +LE + Q++ +L+ R
Sbjct: 342 VDFYKARMEELREDNIILIETKAMLEEQLTAARARGDKVHELEKENLQLKSKLHDLELDR 401
Query: 377 QEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLR---------------EANE-- 419
+ + E+ L E LE + E L E + L E NE
Sbjct: 402 DTDKKRIEELLEENMVLEIAQKQSMNESAHLGWELEQLSKNADLSDASRKSFVFELNECA 461
Query: 420 ---------ELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKR 470
E + Q +GL A L+ + L E + L+ QLE ++
Sbjct: 462 SSRILKLEKENQSLQSTIQGLRDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREK 521
Query: 471 LCRQE----------------------AADRERQ-EELQRHLEDANRARHGLETQHRLNQ 507
Q+ AD+ RQ ++L++ + NRA L + +++
Sbjct: 522 QSNQDLETLSEELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSS 581
Query: 508 Q----------------------QLSELRAQVEDLQKALQEQGGKTEDAISILLKRKLEE 545
+ +LS+L + L + L++ K E A KLE
Sbjct: 582 EARMKDVEKENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERA------EKLER 635
Query: 546 HLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVD 605
LQ+L E + L RK + LE T+ ++E L+H Q + R + R+ +D
Sbjct: 636 ELQRLQEENGRLARK---VTSLETATE-----KVEALEHESQGLQLENRTL----RKSLD 683
Query: 606 KARMVMQTMEPKQRPAAGAPPELHSLRTQLRE-RDVRIRHLEMDFEKSRSQREQEE 660
+ V +E +R E LR + R + +M+ E + +RE+EE
Sbjct: 684 TLQNVSLQLEGLERDNKQLDAENLELRRLVETMRFTSTKLAQMERENQQLEREKEE 739
Score = 77.8 bits (190), Expect = 3e-14
Identities = 102/459 (22%), Positives = 197/459 (42%), Gaps = 40/459 (8%)
Query: 200 QLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQSQLE--QLQEENFRLES 257
+++ L +E QSL GLR+ L+L +S L+ +L++EN +L
Sbjct: 464 RILKLEKENQSLQSTIQGLRDA---------------SLVLEESGLKCGELEKENHQLS- 507
Query: 258 GREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDELRQSSERA-GQLEATLTS 316
++ E+L+ +LERE Q L +E + L+ +M+ L+ R LE
Sbjct: 508 -KKIEKLQ-TQLEREKQSNQDLETLSEELIREKEQLQSDMETLKADKARQIKDLEQEKDH 565
Query: 317 CRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRAQLEAQRRQVQELQGQR 376
R + LRE R QV E R + + L + A +QLE ++RQ+ Q
Sbjct: 566 LNRAMWSLRE-RSQVSS-EARMKDVEKENKALHQTVTEANGKLSQLEFEKRQLHRDLEQA 623
Query: 377 QEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEELRCAQLQPRGLTQADP 436
+E+ +AEK E + L+E+ + ++ L + + E + QL+ R L ++
Sbjct: 624 KEKGERAEKLERELQRLQEENGRLARKVTSLETATEKVEALEHESQGLQLENRTLRKSLD 683
Query: 437 SLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQEAADRERQ-EELQRHLEDANRA 495
+L S ++ L + + LR +E R + A ER+ ++L+R E+ +
Sbjct: 684 TLQNVSLQLEGLERDNKQLDAENLELRRLVETMRFTSTKLAQMERENQQLEREKEELRKN 743
Query: 496 RHGLETQHRLNQQ-QLSELRAQVED--LQKALQEQGGKTEDAISILLKRKLEEHLQKLHE 552
L+ + +++ +LS E+ LQ++L+ KT+ LE L +L
Sbjct: 744 VDLLKALGKKSERLELSYQSVSAENLRLQQSLESSSHKTQ---------TLESELGELEA 794
Query: 553 ADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQ 612
L+R E + + + R + L+ + + + D + +E+ +R + +
Sbjct: 795 ERQALRRDLEALRLANAQLEGAEKDR-KALEQEVAQLEKDKKLLEKEAKRLWQQVELKDA 853
Query: 613 TMEPKQRPAAGAPPELHSLRTQL---RERDVRIRHLEMD 648
++ + E +L +L R+ +++ LE D
Sbjct: 854 VLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKD 892
Score = 65.5 bits (158), Expect = 2e-10
Identities = 88/403 (21%), Positives = 168/403 (41%), Gaps = 41/403 (10%)
Query: 184 AEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQS 243
+ E D+L Q + LL +E S + + E + T + +K++LL++
Sbjct: 925 SSELDKLSQELEKVGLNRELLLQEDDSGSDTKYKILEGRNESALKTTLAMKEEKIVLLEA 984
Query: 244 QLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQAL---------- 293
Q+E+ N +LES + + C L + E QH + A + A
Sbjct: 985 QMEEKASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGPG 1044
Query: 294 -KDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAER--TRQLED 350
K+ EL + +RA +LE + + E + L+ Q++ LE +N + + T Q +
Sbjct: 1045 HKEATMELLRVKDRAIELERNNAALQ---AEKQLLKEQLQHLETQNVTFSSQILTLQKQS 1101
Query: 351 ELRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNL--EEKYESVTKEKERLL 408
+ + Q + + QV+ Q A+ A+ L + + E + ES+ +++E+L
Sbjct: 1102 AFLQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETENESLQRQQEQLT 1161
Query: 409 AERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLEN 468
A ++L + +E L L R + + + S L+ L+LE+
Sbjct: 1162 AAYEALLQDHEHL--GTLHERQSAEYEALIRQHSC-------------LKTLHRNLELEH 1206
Query: 469 KRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSE---LRAQVEDLQKALQ 525
K L + +R+ EL+ + R L+ + R N + E LR +++ +
Sbjct: 1207 KELGERHGDMLKRKAELEEREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHH 1266
Query: 526 EQGGKTEDAISILLKRKLEEHLQKLHEADLELQRKREYIEELE 568
+ G+ E+ L +E L+ A LEL R + +EL+
Sbjct: 1267 QLKGEYEE-----LHAHTKELKTSLNNAQLELNRWQARFDELK 1304
Score = 62.4 bits (150), Expect = 1e-09
Identities = 125/571 (21%), Positives = 222/571 (38%), Gaps = 96/571 (16%)
Query: 181 SEEAEEGDELQQRCLDLERQLMLLSEEK----QSLAQENAGLRERMGRPEG-----EGTP 231
+++ E E ++ +DL + L SE QS++ EN L++ + E
Sbjct: 730 NQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSSHKTQTLESEL 789
Query: 232 GLTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEA- 290
G + L+ LE L+ N +LE +D + LE+EVA+L+ + L A+
Sbjct: 790 GELEAERQALRRDLEALRLANAQLEGAEKDRKA----LEQEVAQLEKDKKLLEKEAKRLW 845
Query: 291 -------QALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAE 343
L D +L + + L+ L CR G+L+EL + R L ++ HA
Sbjct: 846 QQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDNRDLTKQVTVHAR 905
Query: 344 RTRQLEDEL----RRAGSLRAQLEAQRRQVQE----------------------LQGQRQ 377
L ++L ++ L ++L+ +++++ L+G+ +
Sbjct: 906 TLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSDTKYKILEGRNE 965
Query: 378 EE-----AMKAEKWLFECRNLEEK---YESVTKEKERLLAERDSLRE---ANEELRCAQL 426
AMK EK + +EEK + E + L E ++LR+ + L+ +
Sbjct: 966 SALKTTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFK 1025
Query: 427 QPRGLTQADPSLDPTSTP-----------VDNLAAEI------LPAE---LRETLLRLQL 466
P G T A P V + A E+ L AE L+E L L+
Sbjct: 1026 HPAGKTAASHQGKEAWGPGHKEATMELLRVKDRAIELERNNAALQAEKQLLKEQLQHLET 1085
Query: 467 ENKRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQ----- 521
+N Q +++ LQ H L+ ++ Q + L AQ LQ
Sbjct: 1086 QNVTFSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTA 1145
Query: 522 -----KALQEQGGKTEDAISILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTA 576
++LQ Q + A LL+ EHL LHE ++ EY + + T
Sbjct: 1146 KETENESLQRQQEQLTAAYEALLQD--HEHLGTLHE-----RQSAEYEALIRQHSCLKTL 1198
Query: 577 RRIEELQH-NLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQL 635
R EL+H L ++ D+ + + ++ +QR A A E LR +L
Sbjct: 1199 HRNLELEHKELGERHGDMLKRKAELEEREKVLTTEREALQQEQRTNALAMGENQRLRGEL 1258
Query: 636 RERDVRIRHLEMDFEKSRSQREQEEKLLISA 666
+ L+ ++E+ + ++ + L +A
Sbjct: 1259 DRVNFLHHQLKGEYEELHAHTKELKTSLNNA 1289
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 130 bits (328), Expect = 3e-30
Identities = 177/743 (23%), Positives = 335/743 (45%), Gaps = 114/743 (15%)
Query: 12 LLTWLQTFHVPSPCASPQD--------LSSGLAVAYVLNQIDPSWFNEAWLQGISEDPGP 63
L+TW++TF P A+ L G+ + V+ QI+P ++ + ++ D
Sbjct: 18 LVTWVKTF---GPLAAGNGTNLDEYVALVDGVFLNQVMLQINPKLESQRVNKKVNNDAS- 73
Query: 64 NWKLKVSNLKMVLRSLVEYSQDVLAHPVSEEHLPDVSLIGE--FSDPA--ELGKLLQLVL 119
L++ NL +++R + Y Q+ L + LP+V +IG+ FS+ E+ KLL L+L
Sbjct: 74 ---LRMHNLSILVRQIKFYYQETLQQLIMMS-LPNVLIIGKNPFSEQGTEEVKKLLLLLL 129
Query: 120 GCAISCEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYF 179
GCA+ C+KK++ I+RI L+ + V IQE+ FD Q
Sbjct: 130 GCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQE---------NVFDLQWMEVTD 180
Query: 180 LSEEAEEGDELQQRCLDLERQLMLLSEEKQS---LAQENAGLR----ERMGRPEGEGTPG 232
+S+E E L+ L L+R + E ++ L++E GL G+PG
Sbjct: 181 MSQEDIE-PLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPG 239
Query: 233 LT--------AKKLLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALT 284
+ + +L ++++ +L++E D + ++E E+ LQ N L
Sbjct: 240 MKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLL 299
Query: 285 SLAQEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAER 344
S A+ A+ +DE+D LR+ + R +LE+ ++ + RL ++ + +V +L+E N E
Sbjct: 300 SDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLET 359
Query: 345 TRQLEDELR--RAGS------------LRAQL-------EAQRRQVQELQGQRQEEAMKA 383
LED+L RA S L+A+L + R++++EL + M
Sbjct: 360 KTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQ 419
Query: 384 EKWLFECRNLEEKYESVTKEKERLLAERDSL-REANE----ELRCAQLQPRGLTQADPSL 438
++ + E +L + E +++ E A + SL E NE L +++ + LT+ L
Sbjct: 420 KQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEEL 479
Query: 439 DPTSTPVDNLAAEILPAEL-------------------RETLLRLQLENKRLCRQEA--- 476
T V+ A++IL E +++L Q +K L +++A
Sbjct: 480 RTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLE 539
Query: 477 ----ADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQ---KALQEQGG 529
RE E + LE N H +T L Q+ A+V+D++ K L E
Sbjct: 540 KTIETLRENSERQIKILEQEN--EHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIK 597
Query: 530 KTEDAISIL------LKRKLEEHLQKLHEADLELQRKREYIE-ELEPPTDSSTARRIE-E 581
+T +S + +K++LE + +K A+ EL+ + ++E E E T +I E
Sbjct: 598 ETSSKLSKIEFEKRQIKKELEHYKEKGERAE-ELENELHHLEKENELLQKKITNLKITCE 656
Query: 582 LQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLR---TQLRER 638
L++++++L + ++ +D + + +E ++ + E LR L+
Sbjct: 657 KIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCA 716
Query: 639 DVRIRHLEMDFEKSRSQREQEEK 661
+++ L+++ ++ S++EQ +K
Sbjct: 717 SMKMAQLQLENKELESEKEQLKK 739
Score = 72.0 bits (175), Expect = 2e-12
Identities = 117/513 (22%), Positives = 218/513 (42%), Gaps = 74/513 (14%)
Query: 185 EEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQSQ 244
+E L + + +L + EK+ + +E +E+ R E L+++
Sbjct: 587 KENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEE-------------LENE 633
Query: 245 LEQLQEENFRLESGREDERLRCAE---LEREVAELQHRNQ--------------ALTSLA 287
L L++EN L+ + ++ C + LE+E +EL+ N+ L SL
Sbjct: 634 LHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLE 693
Query: 288 QEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQ 347
+E L +E ELR++ E + + EL + Q+++ E ++T +
Sbjct: 694 KENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTER 753
Query: 348 LEDELR----RAGSLRAQLEAQRRQVQELQGQRQE---EAMKAEKWLFECRNLEEKYESV 400
LE + L+ LE +++Q+L+ + Q+ E +K L E + ++ E +
Sbjct: 754 LEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQL 813
Query: 401 TKEKERLLAERDSLREANEELRCAQLQPRGLTQ-ADPSLDPTSTPVDNLAAE--ILPAEL 457
KE + L E L + ++L + R + D +L+ + + NL E L E+
Sbjct: 814 EKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEI 873
Query: 458 ---RETLLR---LQLENKRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLS 511
+E+ +R L+ ENK L ++ D + L+ L L+TQ N L
Sbjct: 874 GIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDL-----VSEKLKTQQMNN--DLE 926
Query: 512 ELRAQVEDL---QKALQEQGGKTEDAISILLKRKLEEHLQKLHEADLELQRKREYIEELE 568
+L ++E + ++ L T+D+ LL+ KLE L+K L+ K E I LE
Sbjct: 927 KLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKK------SLEIKEEKIAALE 980
Query: 569 PPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPP-- 626
+ ST ++L+ L+ + A+++R D+ RMV + P +G
Sbjct: 981 ARLEESTNYN-QQLRQELKTVKKNYEALKQRQ----DEERMVQSS-----PPISGEDNKW 1030
Query: 627 ELHSLRTQLRERDVRIRHLEMDFEKSRSQREQE 659
E S T V+ R +E++ + Q E++
Sbjct: 1031 ERESQETTRELLKVKDRLIEVERNNATLQAEKQ 1063
Score = 53.1 bits (126), Expect = 9e-07
Identities = 115/505 (22%), Positives = 204/505 (40%), Gaps = 85/505 (16%)
Query: 180 LSEEAEEGDELQQRC-LDLERQLML---LSEEKQSLAQENAGLRERMGRPEGEGTPGLTA 235
L E +E EL +R +D++ + L L EK Q N L + E GL
Sbjct: 883 LKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELE---KIGLNK 939
Query: 236 KKLL------------LLQSQLEQLQEENFRLESGREDERLRCAE--LEREVAELQHRNQ 281
++LL LL+S+LE +++ ++ +E++ E LE Q Q
Sbjct: 940 ERLLHDEQSTDDSRYKLLESKLESTLKKSLEIK----EEKIAALEARLEESTNYNQQLRQ 995
Query: 282 ALTSLAQEAQALKDEMDELRQ---SSERAGQLEATLTSCRRRLGELRELRRQVRQLEERN 338
L ++ + +ALK DE R S +G+ + EL +++ ++ ++E N
Sbjct: 996 ELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNN 1055
Query: 339 AGHAERTRQLEDELRRA----GSLRAQLEAQRRQVQELQGQR-----QEEAMKAE----- 384
A + L+ +L++ +L+AQ+ A +RQ LQ Q Q ++ E
Sbjct: 1056 ATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLN 1115
Query: 385 -----------KWLFECRNLEEKYESVTKEKERLLAERDSLREANEELRCAQLQPRGLTQ 433
+ L + +LE + ESV KE+E L + DSL + +E+L L R ++
Sbjct: 1116 SQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLEL--LHERQASE 1173
Query: 434 ADPSLDPTST-PVDNLAAEILPAELRETLLRLQLENKRLCRQEAADRERQEELQRHLEDA 492
+ + T + E+ +L + +L + +L E + QE++ LE+
Sbjct: 1174 YESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKML--LENK 1231
Query: 493 NRARHGLE------TQHRLNQQQLSELRAQVEDLQ---KALQE--QGGKTEDAISILLKR 541
N E RLN S+L + E LQ K L+ K E
Sbjct: 1232 NHETVAAEYKKLCGENDRLN-HTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFS 1290
Query: 542 KLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQ-----------HNLQKKD 590
KL+E Q+L +L + E + +L+ + ++++Q N++ KD
Sbjct: 1291 KLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKD 1350
Query: 591 ADLRAMEERYRRYVDKARMVMQTME 615
R+Y+DK + + E
Sbjct: 1351 ----LFHVEQRQYIDKLNELRRQKE 1371
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 130 bits (328), Expect = 3e-30
Identities = 177/743 (23%), Positives = 335/743 (45%), Gaps = 114/743 (15%)
Query: 12 LLTWLQTFHVPSPCASPQD--------LSSGLAVAYVLNQIDPSWFNEAWLQGISEDPGP 63
L+TW++TF P A+ L G+ + V+ QI+P ++ + ++ D
Sbjct: 18 LVTWVKTF---GPLAAGNGTNLDEYVALVDGVFLNQVMLQINPKLESQRVNKKVNNDAS- 73
Query: 64 NWKLKVSNLKMVLRSLVEYSQDVLAHPVSEEHLPDVSLIGE--FSDPA--ELGKLLQLVL 119
L++ NL +++R + Y Q+ L + LP+V +IG+ FS+ E+ KLL L+L
Sbjct: 74 ---LRMHNLSILVRQIKFYYQETLQQLIMMS-LPNVLIIGKNPFSEQGTEEVKKLLLLLL 129
Query: 120 GCAISCEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYF 179
GCA+ C+KK++ I+RI L+ + V IQE+ FD Q
Sbjct: 130 GCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQE---------NVFDLQWMEVTD 180
Query: 180 LSEEAEEGDELQQRCLDLERQLMLLSEEKQS---LAQENAGLR----ERMGRPEGEGTPG 232
+S+E E L+ L L+R + E ++ L++E GL G+PG
Sbjct: 181 MSQEDIE-PLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPG 239
Query: 233 LT--------AKKLLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALT 284
+ + +L ++++ +L++E D + ++E E+ LQ N L
Sbjct: 240 MKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLL 299
Query: 285 SLAQEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAER 344
S A+ A+ +DE+D LR+ + R +LE+ ++ + RL ++ + +V +L+E N E
Sbjct: 300 SDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLET 359
Query: 345 TRQLEDELR--RAGS------------LRAQL-------EAQRRQVQELQGQRQEEAMKA 383
LED+L RA S L+A+L + R++++EL + M
Sbjct: 360 KTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQ 419
Query: 384 EKWLFECRNLEEKYESVTKEKERLLAERDSL-REANE----ELRCAQLQPRGLTQADPSL 438
++ + E +L + E +++ E A + SL E NE L +++ + LT+ L
Sbjct: 420 KQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEEL 479
Query: 439 DPTSTPVDNLAAEILPAEL-------------------RETLLRLQLENKRLCRQEA--- 476
T V+ A++IL E +++L Q +K L +++A
Sbjct: 480 RTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLE 539
Query: 477 ----ADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQ---KALQEQGG 529
RE E + LE N H +T L Q+ A+V+D++ K L E
Sbjct: 540 KTIETLRENSERQIKILEQEN--EHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIK 597
Query: 530 KTEDAISIL------LKRKLEEHLQKLHEADLELQRKREYIE-ELEPPTDSSTARRIE-E 581
+T +S + +K++LE + +K A+ EL+ + ++E E E T +I E
Sbjct: 598 ETSSKLSKIEFEKRQIKKELEHYKEKGERAE-ELENELHHLEKENELLQKKITNLKITCE 656
Query: 582 LQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLR---TQLRER 638
L++++++L + ++ +D + + +E ++ + E LR L+
Sbjct: 657 KIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCA 716
Query: 639 DVRIRHLEMDFEKSRSQREQEEK 661
+++ L+++ ++ S++EQ +K
Sbjct: 717 SMKMAQLQLENKELESEKEQLKK 739
Score = 69.3 bits (168), Expect = 1e-11
Identities = 117/513 (22%), Positives = 217/513 (42%), Gaps = 75/513 (14%)
Query: 185 EEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQSQ 244
+E L + + +L + EK+ + +E +E+ R E L+++
Sbjct: 587 KENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEE-------------LENE 633
Query: 245 LEQLQEENFRLESGREDERLRCAE---LEREVAELQHRNQ--------------ALTSLA 287
L L++EN L+ + ++ C + LE+E +EL+ N+ L SL
Sbjct: 634 LHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLE 693
Query: 288 QEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQ 347
+E L +E ELR++ E + + EL + Q+++ E ++T +
Sbjct: 694 KENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTER 753
Query: 348 LEDELR----RAGSLRAQLEAQRRQVQELQGQRQE---EAMKAEKWLFECRNLEEKYESV 400
LE + L+ LE +++Q+L+ + Q+ E +K L E + ++ E +
Sbjct: 754 LEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQL 813
Query: 401 TKEKERLLAERDSLREANEELRCAQLQPRGLTQ-ADPSLDPTSTPVDNLAAE--ILPAEL 457
KE + L E L + ++L + R + D +L+ + + NL E L E+
Sbjct: 814 EKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEI 873
Query: 458 ---RETLLR---LQLENKRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLS 511
+E+ +R L+ ENK L ++ D + L+ L L+TQ N L
Sbjct: 874 GIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDL-----VSEKLKTQQMNN--DLE 926
Query: 512 ELRAQVEDL---QKALQEQGGKTEDAISILLKRKLEEHLQKLHEADLELQRKREYIEELE 568
+L ++E + ++ L T+D LL+ KLE L+K L+ K E I LE
Sbjct: 927 KLTHELEKIGLNKERLLHDEQSTDDRYK-LLESKLESTLKK------SLEIKEEKIAALE 979
Query: 569 PPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPP-- 626
+ ST ++L+ L+ + A+++R D+ RMV + P +G
Sbjct: 980 ARLEESTNYN-QQLRQELKTVKKNYEALKQRQ----DEERMVQSS-----PPISGEDNKW 1029
Query: 627 ELHSLRTQLRERDVRIRHLEMDFEKSRSQREQE 659
E S T V+ R +E++ + Q E++
Sbjct: 1030 ERESQETTRELLKVKDRLIEVERNNATLQAEKQ 1062
Score = 57.8 bits (138), Expect = 3e-08
Identities = 94/411 (22%), Positives = 169/411 (41%), Gaps = 49/411 (11%)
Query: 180 LSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLL 239
L + + + LQ + L L+RQ + L E+ +L +NA L+ + T + L
Sbjct: 1068 LKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQL 1127
Query: 240 LLQSQLEQLQEENFRLESGREDERLRCAEL--EREVAELQHRNQALTSLAQEAQALKDEM 297
L+Q L+ EN + RED + L + E EL H Q A E ++L +
Sbjct: 1128 LIQQ--SSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQ-----ASEYESLISKH 1180
Query: 298 DELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGS 357
L+ + + L + R LE+R ++ QLED
Sbjct: 1181 GTLKSAH--------------------KNLEVEHRDLEDRYNQLLKQKGQLED------- 1213
Query: 358 LRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREA 417
L L+ ++ ++ + A + +K E L Y + KE E L + +L+
Sbjct: 1214 LEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSL 1273
Query: 418 --NEELRCAQLQPR--GLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCR 473
N +L +L+ L + LD TST ++N E+L ++L+ L+ EN+ L
Sbjct: 1274 LNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNN-QCELL-SQLKG---NLEEENRHLLD 1328
Query: 474 QEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTED 533
Q + L LE ++ + R +L+ELR Q E L++ + +Q +
Sbjct: 1329 QIQTLMLQNRTL---LEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDP 1385
Query: 534 AISILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQH 584
+ + ++KL ++ ++ R+R+ L PT S ++ +L H
Sbjct: 1386 SPPRRRGNWITLKMRKLIKSKKDINRERQKSLTL-TPTRSDSSEGFLQLPH 1435
Score = 56.2 bits (134), Expect = 1e-07
Identities = 127/581 (21%), Positives = 231/581 (39%), Gaps = 77/581 (13%)
Query: 197 LERQLMLLSEEKQSLAQENAGL-RERMGRPEGEGTPGLTAKKLLLLQSQLEQLQEENFRL 255
L+ Q M EK + E GL +ER+ E T + LL+S+LE +++ +
Sbjct: 916 LKTQQMNNDLEKLTHELEKIGLNKERLLHDEQS-----TDDRYKLLESKLESTLKKSLEI 970
Query: 256 ESGREDERLRCAE--LEREVAELQHRNQALTSLAQEAQALKDEMDELRQ---SSERAGQL 310
+ +E++ E LE Q Q L ++ + +ALK DE R S +G+
Sbjct: 971 K----EEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGED 1026
Query: 311 EATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRA----GSLRAQLEAQR 366
+ EL +++ ++ ++E NA + L+ +L++ +L+AQ+ A +
Sbjct: 1027 NKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQ 1086
Query: 367 RQVQELQGQR-----QEEAMKAE----------------KWLFECRNLEEKYESVTKEKE 405
RQ LQ Q Q ++ E + L + +LE + ESV KE+E
Sbjct: 1087 RQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKERE 1146
Query: 406 RLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTST-PVDNLAAEILPAELRETLLRL 464
L + DSL + +E+L L R ++ + + T + E+ +L + +L
Sbjct: 1147 DLKSLYDSLIKDHEKLEL--LHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQL 1204
Query: 465 QLENKRLCRQEAADRERQEELQRHLEDANRARHGLE------TQHRLNQQQLSELRAQVE 518
+ +L E + QE++ LE+ N E RLN S+L + E
Sbjct: 1205 LKQKGQLEDLEKMLKVEQEKML--LENKNHETVAAEYKKLCGENDRLN-HTYSQLLKETE 1261
Query: 519 DLQ---KALQE--QGGKTEDAISILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDS 573
LQ K L+ K E KL+E Q+L +L + E + +L+ +
Sbjct: 1262 VLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEE 1321
Query: 574 STARRIEELQ-----------HNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAA 622
++++Q N++ KD R+Y+DK + + E +
Sbjct: 1322 ENRHLLDQIQTLMLQNRTLLEQNMESKD----LFHVEQRQYIDKLNELRRQKEKLEEKIM 1377
Query: 623 GAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMG----MALQQRA 678
+ R + ++ ++ K RE+++ L ++ + + L +
Sbjct: 1378 DQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQD 1437
Query: 679 GEERAPAHAQSFLAQQRLAT-NSRRGPLGRLASLNLRPTDK 718
++ + + S Q L T S L RL L RP DK
Sbjct: 1438 SQDSSSVGSNSLEDGQTLGTKKSSMVALKRLPFLRNRPKDK 1478
>gi|16262452 cingulin [Homo sapiens]
Length = 1203
Score = 102 bits (254), Expect = 1e-21
Identities = 143/569 (25%), Positives = 244/569 (42%), Gaps = 83/569 (14%)
Query: 180 LSEEAEEGDELQQRCLDLERQL--------------MLLSEEKQSLAQENAGLRERMGRP 225
L EA+ G EL+++ L L++ L M+ E L Q A + +
Sbjct: 669 LRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRET 728
Query: 226 EGEGTPGLTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALT- 284
+ E +++L L+ +QL+E ++ G E +L+R AE Q +AL
Sbjct: 729 QEENDE--FRRRILGLE---QQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNA 783
Query: 285 ------SLAQEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRE-LRRQVRQLEER 337
SLA +AL+ ++E ++ R GQ + TL G+ RE LRR +LEE+
Sbjct: 784 SQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQ 843
Query: 338 NAGHAERTRQLEDELRRAGS--------LRAQLE----AQRRQVQELQGQRQEEAMKAEK 385
+L EL + G L+AQLE RR+V + Q Q ++ A +AEK
Sbjct: 844 KRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEK 903
Query: 386 WLFECRNLEEKYESVTKEKERLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPV 445
L+++ + + + + AERD+ R ++EL +LQ GL Q +
Sbjct: 904 TSGGLSRLQDEIQRLRQALQASQAERDTAR-LDKELLAQRLQ--GLEQ---EAENKKRSQ 957
Query: 446 DNLAAEILPAELRETLLRLQLENKRLCRQEAADR-----ERQEELQRHLEDANRARHGLE 500
D+ A ++ E + + L +L+ ++ + DR ++ ++L+ L AR LE
Sbjct: 958 DDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLE 1017
Query: 501 TQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDAISILLKRKLEEHLQKLHEADLELQRK 560
L Q +DL+ L G + + S+ +LE Q L E +R+
Sbjct: 1018 CDK-------ISLERQNKDLKTRLASSEGFQKPSASL---SQLESQNQLLQERLQAEERE 1067
Query: 561 REYIEELEPPTDSSTARRIEEL--------QH-NLQKKDADLRAMEERYRRYVDKARMVM 611
+ ++ T+ R+++EL QH N QK LR + +R VD+A +
Sbjct: 1068 KTVLQS----TNRKLERKVKELSIQIEDERQHVNDQKDQLSLRV--KALKRQVDEAEEEI 1121
Query: 612 QTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMG 671
+ ++ ++ A E H + QL+ RI+ LE D + S+ E SA N G
Sbjct: 1122 ERLDGLRKKAQREVEEQHEVNEQLQ---ARIKSLEKDSWRKASRSAAE-----SALKNEG 1173
Query: 672 MALQQRAGEERAPAHAQSFLAQQRLATNS 700
++ + P+ S L + L T+S
Sbjct: 1174 LSSDEEFDSVYDPSSIASLLTESNLQTSS 1202
Score = 81.3 bits (199), Expect = 3e-15
Identities = 147/580 (25%), Positives = 245/580 (42%), Gaps = 84/580 (14%)
Query: 109 AELGKLLQLVLGCAISCEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYG 168
+ L +LL+ G A K+ +++R++ E ++H + + EL K PE
Sbjct: 404 SRLQELLERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNK-LKHVQGPEPAK 462
Query: 169 NF---DSQSRRYYFLSEEAEEGDELQQRCLDL-ERQLMLLS----EEKQSLAQENAGLR- 219
D R L EE EG + + L L ER+L L EE S QE +R
Sbjct: 463 EVLLKDLLETRE--LLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQ 520
Query: 220 ------ERMGRPEGEGTPG---LTAKKLLL------LQSQLEQLQEENFRLESGREDERL 264
E++ R + T L A++ + LQ +LE+ EE +S + +
Sbjct: 521 QYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKE 580
Query: 265 RCAELEREVAELQHRNQALTS-LAQEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGE 323
++E+ +L+ + + L ++ + L+ E+++ R S+ Q+E R E
Sbjct: 581 DLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEE 640
Query: 324 LRELRRQVRQLEERNAGHAERTRQLEDEL---RRAGSLRAQLEAQRRQVQE-LQGQRQ-- 377
L+EL+ + RQ +E H R R+LE +L R +LE Q Q+Q+ LQ RQ
Sbjct: 641 LKELQAE-RQSQEVAGRH--RDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDC 697
Query: 378 EEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEELRCAQLQPRGLTQADPS 437
EEA KA K + E T +R A +LRE EE + + GL Q
Sbjct: 698 EEASKA-KMVAEAE--------ATVLGQRRAAVETTLRETQEENDEFRRRILGLEQ---Q 745
Query: 438 LDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQEAADRERQEELQRHLEDANRARH 497
L T VD E + A LR+ L RL+ E ++L +EA + ++EE A+
Sbjct: 746 LKETRGLVDG--GEAVEARLRDKLQRLEAEKQQL--EEALNASQEEE-----GSLAAAKR 796
Query: 498 GLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDAISILLKRKLEEHLQKLHEADLEL 557
LE + Q+ L+ L + + L +AL+E+G + E L
Sbjct: 797 ALEARLEEAQRGLARLGQEQQTLNRALEEEGKQRE-----------------------VL 833
Query: 558 QRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPK 617
+R + +EE + D + R +EL+ + L+ ++ + Y +KAR + +
Sbjct: 834 RRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKAR---REVADA 890
Query: 618 QRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQRE 657
QR A E L I+ L + S+++R+
Sbjct: 891 QRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERD 930
Score = 72.8 bits (177), Expect = 1e-12
Identities = 138/589 (23%), Positives = 234/589 (39%), Gaps = 109/589 (18%)
Query: 153 LMTKDTPDSLSPETY----GNFDSQSRRYYFLSEEAEEGDELQQRCLDLERQLMLLSEEK 208
L K TPD L + G+ D Y + E E R R++ L+ E+
Sbjct: 290 LQFKSTPDLLRDQQEAAPPGSVDHMKATIYGILREGSSESETSVR-----RKVSLVLEKM 344
Query: 209 QSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQSQLEQ-------LQEENFRLESGRED 261
Q L ++G + + +GE T +K+ LQ +L++ L+ LE E+
Sbjct: 345 QPLVMVSSGSTKAVAG-QGELT-----RKVEELQRKLDEEVKKRQKLEPSQVGLERQLEE 398
Query: 262 ERLRCAEL----EREVAELQHRNQALTSLAQEAQALKDEMDELRQSSE-RAGQLEATLTS 316
+ C+ L ER E Q N+ L Q + L D+ ++LR E + +L+ L
Sbjct: 399 KTEECSRLQELLERRKGEAQQSNKEL----QNMKRLLDQGEDLRHGLETQVMELQNKLKH 454
Query: 317 CR----------RRLGELRELRRQV---------------------------------RQ 333
+ + L E REL +V ++
Sbjct: 455 VQGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQE 514
Query: 334 LEERNAGHAERTRQLEDELRRAGSLRAQLEAQRRQ----VQELQGQRQEEAMKAEKWLFE 389
+E + T QL ++ A A LEA+R++ V+ LQ + +E + + W
Sbjct: 515 VEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQ-- 572
Query: 390 CRNLEEKYESVTKEKERLLAERDSLREANEEL-RCAQLQPRGLTQADPSLDPTSTPVDNL 448
++ E + K+ LL R E EEL ++ R L QA S T V+ L
Sbjct: 573 -SMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDT-RQVEVL 630
Query: 449 AAEILPAELRETLLRLQLENKRLCRQEAADRERQEELQRHLE----DANRARHGLETQHR 504
E+L +E L LQ E + QE A R R EL++ L +A+R R LE Q+
Sbjct: 631 KKELL--RTQEELKELQAERQ---SQEVAGRHRDRELEKQLAVLRVEADRGRE-LEEQNL 684
Query: 505 LNQQQLSELRAQVEDLQKALQEQGGKTEDAISILLKRKLEEHLQKLHEADLELQRK---- 560
Q+ L +LR E+ KA + + E + + +E L++ E + E +R+
Sbjct: 685 QLQKTLQQLRQDCEEASKA--KMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGL 742
Query: 561 REYIEELEPPTDSSTA------RRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTM 614
+ ++E D A +++ L+ Q+ + L A +E R + +
Sbjct: 743 EQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARL 802
Query: 615 EPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEEKLL 663
E QR A E +L L E + L + +++ E++++LL
Sbjct: 803 EEAQRGLARLGQEQQTLNRALEEEGKQREVL----RRGKAELEEQKRLL 847
Score = 61.2 bits (147), Expect = 3e-09
Identities = 90/381 (23%), Positives = 154/381 (40%), Gaps = 77/381 (20%)
Query: 367 RQVQELQGQRQEEAMKAEK----WLFECRNLEEKYESVTKEKERLLAERDSLREANEELR 422
R+V+ELQ + EE K +K + R LEEK E ++ +E L + +++N+EL
Sbjct: 366 RKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKEL- 424
Query: 423 CAQLQPRGLTQADPSLDPTSTPVDNL------------AAEILPAELRET--LLRLQLEN 468
Q R L Q + T V L A E+L +L ET LL LE
Sbjct: 425 --QNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEG 482
Query: 469 KRLCRQEAADRERQ-----------------------EELQRHLEDANRARHGLETQHRL 505
K+ ++ RER+ ++ QR E R+ H +
Sbjct: 483 KQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAV 542
Query: 506 NQQQLSELRAQVEDLQKALQEQGGKTEDAISILLKRKLEEHLQKLHEADLELQRKREYIE 565
+ + ++ A V LQ+ L+E +T S+ K K E L+ + L+L+ ++E +E
Sbjct: 543 LEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNK--EDLRATKQELLQLRMEKEEME 600
Query: 566 ELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAP 625
E +IE LQ L++ RA R+ + +++T E
Sbjct: 601 E-------ELGEKIEVLQRELEQ----ARASAGDTRQVEVLKKELLRTQE---------- 639
Query: 626 PELHSLRTQLRERDVRIRHLEMDFEK---------SRSQREQEEKLLISAWYNMGMALQQ 676
EL L+ + + ++V RH + + EK R + +E+ L + +
Sbjct: 640 -ELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCE 698
Query: 677 RAGEERAPAHAQSFLAQQRLA 697
A + + A A++ + QR A
Sbjct: 699 EASKAKMVAEAEATVLGQRRA 719
Score = 51.6 bits (122), Expect = 3e-06
Identities = 67/273 (24%), Positives = 107/273 (39%), Gaps = 41/273 (15%)
Query: 107 DPAELGK--LLQLVLGCAISCEKKQ----DHIQRIMTLEESVQHVVMEAIQELMTKDTPD 160
D A L K L Q + G E K+ D +++ LEE V + E +E K+T +
Sbjct: 930 DTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEE---KNTVE 986
Query: 161 SLSPETYGNFDSQSRRYYFLSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRE 220
L+ D + L +E +L+ + LERQ N L+
Sbjct: 987 LLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQ--------------NKDLKT 1032
Query: 221 RMGRPEGEGTPGLTAKKL----LLLQSQLEQLQEENFRLESGREDERLRCAELEREVA-E 275
R+ EG P + +L LLQ +L+ + E L+S + EL ++ E
Sbjct: 1033 RLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDE 1092
Query: 276 LQHRNQALTSLAQEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLE 335
QH N L+ +ALK ++DE + ER L ++ +R+V +
Sbjct: 1093 RQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLR-------------KKAQREVEEQH 1139
Query: 336 ERNAGHAERTRQLEDELRRAGSLRAQLEAQRRQ 368
E N R + LE + R S A A + +
Sbjct: 1140 EVNEQLQARIKSLEKDSWRKASRSAAESALKNE 1172
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 101 bits (251), Expect = 3e-21
Identities = 139/606 (22%), Positives = 259/606 (42%), Gaps = 76/606 (12%)
Query: 121 CAISCEKK--QDHIQRIMTL-----EESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQ 173
C ++ EKK +D I T E+S ++ E M D + L E +
Sbjct: 988 CKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRRE------EK 1041
Query: 174 SRRYYFLSEEAEEGD--ELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTP 231
R+ + EGD +L + +L+ Q+ +E K LA++ L+ + R E E
Sbjct: 1042 QRQELEKTRRKLEGDSTDLSDQIAELQAQI---AELKMQLAKKEEELQAALARVEEEAAQ 1098
Query: 232 -GLTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEA 290
+ KK+ L+SQ+ +LQE+ LES R R AE Q R+ L +E
Sbjct: 1099 KNMALKKIRELESQISELQED---LESER---------ASRNKAEKQKRD-----LGEEL 1141
Query: 291 QALKDEMDELRQSS----ERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTR 346
+ALK E+++ S+ E + E + ++ L E E + Q++E H++
Sbjct: 1142 EALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEE--EAKTHEAQIQEMRQKHSQAVE 1199
Query: 347 QLEDELRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKER 406
+L ++L + ++A LE ++ ++ +G+ E + + + +K E+ +E +
Sbjct: 1200 ELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQV 1259
Query: 407 LLAERDSLR-EANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQ 465
E + +R E +++ Q++ +T D S+ + L ++L++T LQ
Sbjct: 1260 KFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTK-DFSALESQLQDTQELLQ 1318
Query: 466 LENKRLCRQEAADRERQEE---LQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQK 522
EN++ ++ ++E + LE+ A+H LE +Q++ L AQV D++K
Sbjct: 1319 EENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLE-------KQIATLHAQVADMKK 1371
Query: 523 ALQEQGGKTEDAISILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEEL 582
+++ G E A + KRKL++ L+ L + E + +E+ + + +L
Sbjct: 1372 KMEDSVGCLETAEEV--KRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDL 1429
Query: 583 QH------NLQKKD-------ADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGA----- 624
H NL+KK A+ + + +Y D+A + E K A A
Sbjct: 1430 DHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAM 1489
Query: 625 --PPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEER 682
EL L Q R + + D KS + E+ ++ L M L++ E +
Sbjct: 1490 EQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQ 1549
Query: 683 APAHAQ 688
A A+
Sbjct: 1550 ATEDAK 1555
Score = 88.2 bits (217), Expect = 2e-17
Identities = 131/555 (23%), Positives = 240/555 (43%), Gaps = 62/555 (11%)
Query: 180 LSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLL 239
+ E AE+ ++ ++ +LE+ L E+ LA E L + G E K
Sbjct: 1198 VEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSE---------HKRK 1248
Query: 240 LLQSQLEQLQE-----ENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALK 294
+++QL++LQ E R E + +L+ EL+ L + + L ++ AL+
Sbjct: 1249 KVEAQLQELQVKFNEGERVRTELADKVTKLQ-VELDNVTGLLSQSDSKSSKLTKDFSALE 1307
Query: 295 DEM--------DELRQS---SERAGQLEATLTSCRRRLGELRELRRQV-RQLEERNAGHA 342
++ +E RQ S + Q+E S R +L E E + + +Q+ +A A
Sbjct: 1308 SQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVA 1367
Query: 343 ERTRQLEDELRRAGSLRAQLEAQRRQVQELQG--QRQEEAMKAEKWLFECRNLEEKYESV 400
+ +++ED + G L E +R+ ++L+G QR EE + A LE+ +
Sbjct: 1368 DMKKKMEDSV---GCLETAEEVKRKLQKDLEGLSQRHEEKVAAYD------KLEKTKTRL 1418
Query: 401 TKEKERLLAERDSLREANEELRCAQLQPRGLTQADPSLDPT-STPVDNLAAEILPAELRE 459
+E + LL + D R++ L Q + L + ++ + D AE E +
Sbjct: 1419 QQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKA 1478
Query: 460 TLLRLQLENK-----RLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELR 514
L LE L R R E+L +D ++ H LE R +QQ+ E++
Sbjct: 1479 LSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMK 1538
Query: 515 AQVEDLQKALQEQGGKTEDAISILLKRKLEEHLQKLH-EADLELQRKREYIEELEPPTDS 573
Q+E+L+ LQ TEDA K +LE +LQ + + + +LQ + E EE +
Sbjct: 1539 TQLEELEDELQ----ATEDA-----KLRLEVNLQAMKAQFERDLQGRDEQSEEKK----K 1585
Query: 574 STARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQT-MEPKQRPAAGAPPELHSLR 632
R++ E++ L+ + R+M R+ ++ ++ ++ + A +L L+
Sbjct: 1586 QLVRQVREMEAELE-DERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQ 1644
Query: 633 TQLRERDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFLA 692
Q+++ + E+ +Q ++ EK L S M ++ A ERA AQ
Sbjct: 1645 AQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERD 1704
Query: 693 Q--QRLATNSRRGPL 705
+ +A +S +G L
Sbjct: 1705 ELADEIANSSGKGAL 1719
Score = 81.3 bits (199), Expect = 3e-15
Identities = 120/512 (23%), Positives = 228/512 (44%), Gaps = 77/512 (15%)
Query: 195 LDLERQLMLLSEEKQS-----LAQE---NAGLRERMGRPEGEGTPGLTAKKLLLLQSQLE 246
LD +RQ E+KQ LA+E +A E R E E T K L L LE
Sbjct: 1429 LDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKET--KALSLARALE 1486
Query: 247 QLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDELR-QSSE 305
+ E+ LE R +++ R E+E ++ +++ L + +AL+ +++E++ Q E
Sbjct: 1487 EAMEQKAELE--RLNKQFR-TEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEE 1543
Query: 306 RAGQLEATLTSCRRRLGELRELRRQV-RQLEERNAGHAERTRQLEDELRRAGSLRAQLEA 364
+L+AT + R L+ ++ Q R L+ R+ E+ +QL +R+ + A+LE
Sbjct: 1544 LEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQL---VRQVREMEAELED 1600
Query: 365 QRRQVQELQGQRQEEAMKAEKWL-FECRNLEEKYESVTKEKERLLAERDSLREANEELRC 423
+R+Q + A+ A K L + ++LE +S K ++ EA ++LR
Sbjct: 1601 ERKQ--------RSMAVAARKKLEMDLKDLEAHIDSANKNRD----------EAIKQLRK 1642
Query: 424 AQLQPRGLTQADPSLDPTSTPVDNLAAEILPAE-----LRETLLRLQLENKRLCRQEAAD 478
Q Q + + LD T + + A+ E + +++LQ E L E A
Sbjct: 1643 LQAQMKDCMR---ELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEE---LAAAERAK 1696
Query: 479 RERQEELQRHLED-ANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDAISI 537
R+ Q+E ++ AN + G L ++ L A++ L++ L+E+ G TE
Sbjct: 1697 RQAQQERDELADEIANSSGKGA-----LALEEKRRLEARIAQLEEELEEEQGNTELINDR 1751
Query: 538 LLKRKLE------------EHLQKLHEADLELQRKRE----YIEELEPPTDS-------S 574
L K L+ H QK A +L+R+ + ++E+E S +
Sbjct: 1752 LKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITA 1811
Query: 575 TARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQ 634
+I +L+ L + + +A ++ RR K + V+ ++ ++R A + T+
Sbjct: 1812 LEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTR 1871
Query: 635 LRERDVRIRHLEMDFEKSRSQREQEEKLLISA 666
L++ ++ E + +++ + R + ++ L A
Sbjct: 1872 LKQLKRQLEEAEEEAQRANASRRKLQRELEDA 1903
Score = 77.8 bits (190), Expect = 3e-14
Identities = 111/490 (22%), Positives = 219/490 (44%), Gaps = 68/490 (13%)
Query: 189 ELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLL-----QS 243
EL++ C DLE ++ E Q L E +++ + E + +A++ L L ++
Sbjct: 912 ELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEA 971
Query: 244 QLEQLQEENFRLES-----GREDERL--RCAELEREVAELQHRNQALTSLAQEAQALKDE 296
+L++L+EE LE +E + L R AE + E + ++++L L + +A+ +
Sbjct: 972 KLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITD 1031
Query: 297 MDE-LRQSSERAGQLEATLTSCRRRL-GELRELRRQVRQLEERNAGHAERTRQLEDELRR 354
++E LR+ ++ +LE T RR+L G+ +L Q+ +L+ + A
Sbjct: 1032 LEERLRREEKQRQELEKT----RRKLEGDSTDLSDQIAELQAQIA--------------- 1072
Query: 355 AGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSL 414
L+ QL + ++Q + +EEA + L + R LE + +++ +E L +ER S
Sbjct: 1073 --ELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQ---ISELQEDLESERASR 1127
Query: 415 REANEELRCAQLQPRGL-TQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCR 473
+A ++ R + L T+ + +LD T+ + + E +L+ LE +
Sbjct: 1128 NKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKR----EQEVNILKKTLEEE---- 1179
Query: 474 QEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTED 533
+ + + QE Q+H + LE Q ++A +E ++ L+ + G+ +
Sbjct: 1180 AKTHEAQIQEMRQKHSQAVEELAEQLE--------QTKRVKANLEKAKQTLENERGELAN 1231
Query: 534 AISILLKRKLE-EHLQKLHEADL-ELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDA 591
+ +LL+ K + EH +K EA L ELQ K E + + A ++ +LQ L
Sbjct: 1232 EVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVR----TELADKVTKLQVELDNVTG 1287
Query: 592 DLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEK 651
L + + + + ++ Q + SL T+L++ +E +
Sbjct: 1288 LLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQ-------VEDEKNS 1340
Query: 652 SRSQREQEEK 661
R Q E+EE+
Sbjct: 1341 FREQLEEEEE 1350
Score = 71.2 bits (173), Expect = 3e-12
Identities = 108/471 (22%), Positives = 198/471 (42%), Gaps = 110/471 (23%)
Query: 236 KKLLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKD 295
++++ + +L +++E+ E+ + ++L E +LQ + QA T L EA+
Sbjct: 845 EEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAE---- 900
Query: 296 EMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRA 355
+L A LT+ ++ L E+ LE R +E+E R
Sbjct: 901 -------------ELRARLTAKKQELEEI------CHDLEAR----------VEEEEERC 931
Query: 356 GSLRAQLEAQRRQVQELQGQRQEE-------------------AMKAEKWLFECRN---- 392
L+A+ + ++ +QEL+ Q +EE ++ E+ + E +N
Sbjct: 932 QHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLA 991
Query: 393 -----LEEKYESVT------KEKERLLAERDSLREA-----NEELRCAQLQPRGLTQADP 436
LE++ T +EK + LA+ + EA E LR + Q + L +
Sbjct: 992 KEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRR 1051
Query: 437 SLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQEAADRERQE------------- 483
L+ ST + + AE L A++ E L++QL K Q A R +E
Sbjct: 1052 KLEGDSTDLSDQIAE-LQAQIAE--LKMQLAKKEEELQAALARVEEEAAQKNMALKKIRE 1108
Query: 484 ------ELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDL---QKALQEQGGKTEDA 534
ELQ LE +R+ E Q R ++L L+ ++ED A QE K E
Sbjct: 1109 LESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQE 1168
Query: 535 ISILLKRKLEEHLQKLHEADLELQRKR--EYIEELEPPTDSSTARRIEELQHNLQKKDAD 592
++I LK+ LEE K HEA ++ R++ + +EEL + + + ++ NL+K
Sbjct: 1169 VNI-LKKTLEEE-AKTHEAQIQEMRQKHSQAVEEL-----AEQLEQTKRVKANLEKAK-- 1219
Query: 593 LRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIR 643
+ +E ++ ++++Q + +L L+ + E + R+R
Sbjct: 1220 -QTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGE-RVR 1268
Score = 58.2 bits (139), Expect = 3e-08
Identities = 80/318 (25%), Positives = 134/318 (42%), Gaps = 51/318 (16%)
Query: 372 LQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREAN---EELRCAQLQP 428
LQ RQEE M A K E + K +E+ LA + L E +L +LQ
Sbjct: 838 LQVSRQEEEMMA------------KEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQL 885
Query: 429 RGLTQADPSLDPTSTPVDNLAAEILPA--ELRETLLRLQL---ENKRLCRQEAADRERQE 483
+ QA+ L + L A + EL E L+ E + C+ A++++ +
Sbjct: 886 QEQLQAETEL---CAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQ 942
Query: 484 ----ELQRHLEDANRARHGLETQHRLNQQQLSELRAQ---VEDLQKALQEQGGKTEDAIS 536
EL+ LE+ AR L+ + + +L +L + +ED L ++ ED I+
Sbjct: 943 QNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIA 1002
Query: 537 ILLKRKLEEH--------LQKLHEA---DLE--LQRKREYIEELEPPTDSSTARRIEELQ 583
EE L+ HEA DLE L+R+ + +ELE T R++E
Sbjct: 1003 EFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELE-----KTRRKLEGDS 1057
Query: 584 HNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIR 643
+L + A+L+A + + K +Q + A + + ++RE + +I
Sbjct: 1058 TDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAA---QKNMALKKIRELESQIS 1114
Query: 644 HLEMDFEKSRSQREQEEK 661
L+ D E R+ R + EK
Sbjct: 1115 ELQEDLESERASRNKAEK 1132
Score = 52.0 bits (123), Expect = 2e-06
Identities = 73/315 (23%), Positives = 133/315 (42%), Gaps = 39/315 (12%)
Query: 171 DSQSRRYYFLSEEAEEGDELQQ---RCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEG 227
D+++ R L++ E +L+ + L+ +L K+ QE L + + G
Sbjct: 1656 DTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSG 1715
Query: 228 EGTPGLTAKKLLLLQSQLEQLQEENFRLESGRE--DERLRCAELE---------REVAEL 276
+G L K+ L ++++ QL+EE + E ++RL+ A L+ E +
Sbjct: 1716 KGALALEEKRRL--EARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHA 1773
Query: 277 QHRNQALTSLAQEAQALKDEMDELR---QSSERAG--QLEATLTSCRRRL-GELRELRRQ 330
Q A L ++ + LK ++ E+ +S +A LEA + +L E +E +
Sbjct: 1774 QKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAA 1833
Query: 331 VRQLEERNAGHAERTRQLEDELRRAGSLRAQ-------LEAQRRQVQELQGQRQEEAMKA 383
+Q+ + Q++DE R A + Q L+ +RQ++E +EEA +A
Sbjct: 1834 CKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEE----AEEEAQRA 1889
Query: 384 EKWLFECRNLEEKYESVTKEKERLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTST 443
R L+ + E T+ + + E SL+ + PR + + D +
Sbjct: 1890 NA---SRRKLQRELEDATETADAMNREVSSLKNKLRRGDLPFVVPRRMARKGAG-DGSDE 1945
Query: 444 PVDNLA--AEILPAE 456
VD A AE PAE
Sbjct: 1946 EVDGKADGAEAKPAE 1960
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 101 bits (251), Expect = 3e-21
Identities = 128/503 (25%), Positives = 223/503 (44%), Gaps = 72/503 (14%)
Query: 204 LSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQSQLEQLQEENFRLESGREDER 263
L E K L Q+ GL ++G E +++++LQ QL++ +E+ G E+
Sbjct: 1748 LQELKDQLEQQLQGLHRKVG--ETSLLLSQREQEIVVLQQQLQEAREQ------GELKEQ 1799
Query: 264 LRCAELEREVAELQHRNQALTSLAQEAQALKDEMDELRQSSERA-GQLEATLTSCRRRLG 322
++L+ L R+Q L +L QE Q + + + +++ ++ G LE + + R G
Sbjct: 1800 SLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHG 1859
Query: 323 ELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRAQLEAQRRQVQELQGQRQEEAMK 382
EL++ + Q R+LEE A R + LE+ L G LRA+ Q + + LQ Q E+A +
Sbjct: 1860 ELQDHKEQARRLEEELAVEGRRVQALEEVL---GDLRAESREQEKALLALQQQCAEQAQE 1916
Query: 383 AEKWLFECRNLEEKY---ESVTKEK----ERLLAERDSLREANEELRC-AQLQPRGLTQA 434
E E R L++ + ++V KE+ E L AE S R E R A+ L +A
Sbjct: 1917 HE---VETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKA 1973
Query: 435 DPSLDPTSTPVDNLAA-----EILPAELRETLLRLQLENKRLCRQEAADRERQEELQ--- 486
+L + A E A L+ +L Q +++L E A R ++ E+Q
Sbjct: 1974 HAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQL---EEALRIQEGEIQDQD 2030
Query: 487 -RHLEDANRARHGL-----ETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDAISILLK 540
R+ ED + + L E +H+ ++QL E + +QE+ L +
Sbjct: 2031 LRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQN--------LGQ 2082
Query: 541 RKLEEHLQKLHEADLELQ-----RKREYIE--------ELEPPTDSSTARRIEE------ 581
+ EE ++ LH++ ELQ +++E +E LE S +EE
Sbjct: 2083 EREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLD 2142
Query: 582 -----LQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLR 636
LQ L++ A LR E R + +KA+ + ++ + + L+ +
Sbjct: 2143 SLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVL 2202
Query: 637 ERDVRIRHLEMDFEKSRSQREQE 659
ERD + L+ + E +R E+E
Sbjct: 2203 ERDSEQQRLQDELELTRRALEKE 2225
Score = 90.5 bits (223), Expect = 5e-18
Identities = 158/624 (25%), Positives = 263/624 (42%), Gaps = 110/624 (17%)
Query: 127 KKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYFLSEEAEE 186
KKQ + LE H ME Q+L+ E G ++Q L+ + EE
Sbjct: 1549 KKQLVTLECLALELEENHHKMECQQKLIK---------ELEGQRETQRVALTHLTLDLEE 1599
Query: 187 -GDELQQRCL---DLERQLMLLSEEKQSLAQENAGLRER---MGRPEGEGTPGLTAK--K 237
ELQ + DLE +L+ E Q QE RE+ + R + T L + +
Sbjct: 1600 RSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQE 1659
Query: 238 LLLLQSQLEQLQEENFR----LESGREDERLRCAELEREV-------------------- 273
L+L + +++ L+++ R LE E +L E RE+
Sbjct: 1660 LMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKA 1719
Query: 274 --AELQHRNQALTSLAQEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGEL------R 325
L+H L +E + ++ + EL++ + QLE L R++GE R
Sbjct: 1720 QRGSLEHMKLILRDKEKEVECQQEHIHELQELKD---QLEQQLQGLHRKVGETSLLLSQR 1776
Query: 326 E-----LRRQVRQLEERNAGHAERTRQLEDELRRAGSLRAQ-LEAQRRQVQELQGQRQEE 379
E L++Q+++ E+ + + DE +RA + R Q LEA +++ Q+ QGQ +
Sbjct: 1777 EQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERV 1836
Query: 380 AMKAEKWLFECR----NLEEKYESVT--KEKERLLAER--------DSLREANEELRCAQ 425
KA+ L+E++ + KE+ R L E +L E +LR
Sbjct: 1837 KEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAES 1896
Query: 426 ---------LQPRGLTQADPSLDPTSTPVDN-LAAEILPAELRETLLRLQLENKRLCRQE 475
LQ + QA T D+ L A+ + E + L L+ E++ QE
Sbjct: 1897 REQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQE 1956
Query: 476 AADRERQEELQRHLEDANRARHGLETQHRLNQQQLS-ELRAQVEDLQKAL---QEQGGKT 531
A R R E LQ L A+ A G E QH L Q +LS L A LQ +L Q +
Sbjct: 1957 EAARARAEALQEALGKAHAALQGKE-QHLLEQAELSRSLEASTATLQASLDACQAHSRQL 2015
Query: 532 EDAISIL------LKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEE---- 581
E+A+ I + +E +Q+L +A + + + +E E + S A+R++E
Sbjct: 2016 EEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQ 2075
Query: 582 LQHNL--QKKDADLRAMEERYRR----YVDKARMVMQTMEPKQRPAAGAPPELHSLRTQL 635
+ NL ++++ ++R + + R K + +++ E +QR A P HS +T
Sbjct: 2076 EKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALP--HSHKTSP 2133
Query: 636 RERDVRIRHLEMDFEKSRSQREQE 659
E + L++D + R QRE E
Sbjct: 2134 MEE----QSLKLDSLEPRLQRELE 2153
Score = 84.7 bits (208), Expect = 3e-16
Identities = 123/524 (23%), Positives = 230/524 (43%), Gaps = 72/524 (13%)
Query: 188 DELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPE------GEGTPGLTAKKLLLL 241
++L Q E L +EK++L +E A L R+ E E GL++ K LL
Sbjct: 711 EQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELL- 769
Query: 242 QSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDELR 301
+S L + Q++N +E + +LE ++Q QA + E + LK E+D R
Sbjct: 770 ESSLFEAQQQNSVIEVTK-------GQLE---VQIQTVTQAKEVIQGEVRCLKLELDTER 819
Query: 302 QSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGS---- 357
+E+ A R+L + + + LE++ A H + QL ++ + S
Sbjct: 820 SQAEQERDAAA------RQLAQAEQEGKTA--LEQQKAAHEKEVNQLREKWEKERSWHQQ 871
Query: 358 ---------------LRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTK 402
L +L+ Q+ +++ +Q QR+EE +AE L + + LE + E V+
Sbjct: 872 ELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQ-LETEKERVSL 930
Query: 403 EKERLLAERDSLREANEEL-RCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPA--ELRE 459
E LL + L +A+++L R Q + + T + E+ A + R+
Sbjct: 931 -LETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRD 989
Query: 460 TLLRLQLENKRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVED 519
L LQ E+ L + + +LQ+ +ED + RL +Q++ E + ++
Sbjct: 990 DLAALQEESSSLLQDKM-------DLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQE 1042
Query: 520 LQKALQEQGGKTEDAISILLKRKLEEHLQKLHEAD----LELQRKREYIEELEPPTDSST 575
+ +Q++ + + ++++ L K E+ L L EAD EL R+ ++E + +
Sbjct: 1043 YNR-IQKELEREKASLTLSLMEK-EQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELS 1100
Query: 576 ARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQL 635
A ++E L+ +++K+AD A E + ++ + + Q Q A+ E + + QL
Sbjct: 1101 A-QMELLRQEVKEKEADFLAQEAQLLEELEASHITEQ-----QLRASLWAQEAKAAQLQL 1154
Query: 636 RERDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAG 679
R R + + E+ + Q + L S + ALQQ G
Sbjct: 1155 RLRSTESQLEALAAEQQPGNQAQAQAQLASLY----SALQQALG 1194
Score = 82.0 bits (201), Expect = 2e-15
Identities = 130/563 (23%), Positives = 231/563 (41%), Gaps = 60/563 (10%)
Query: 185 EEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQSQ 244
E+G+ + L+ L LL++ +E LR ++ E + A +LL L +
Sbjct: 1407 EQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLK 1466
Query: 245 LEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDELRQSS 304
++ QE + + E +E E+ R LE +Q R Q LT ++ + L+ + + R
Sbjct: 1467 -KRNQEVDLQQEQIQELEKCRSV-LEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVL 1524
Query: 305 E-RAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRAQLE 363
E + +LE + G++++L++Q+ LE E ++E + + L Q E
Sbjct: 1525 EHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRE 1584
Query: 364 AQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEELRC 423
QR + L +E + + + + +LE + +E + E S RE EEL
Sbjct: 1585 TQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEEL-- 1642
Query: 424 AQLQPRGLTQ----ADPSLDPTSTPVDNL------AAEILPAELRETLLRLQLENKRLCR 473
Q Q LTQ D L + L +IL +L + L L+ + L
Sbjct: 1643 -QRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTT 1701
Query: 474 QEAADRERQEE------LQR-HLEDANRARHGLETQHRLNQQ---QLSELRAQVEDLQKA 523
Q +ER EE QR LE E + Q+ +L EL+ Q+E +
Sbjct: 1702 QRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQG 1761
Query: 524 LQEQGGKTEDAISILLKRKLEEHL---QKLHEADLELQRKREYIEELEPPTDSSTARRIE 580
L + G+T S+LL ++ +E + Q+L EA + + K + ++ + A+R +
Sbjct: 1762 LHRKVGET----SLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQ 1817
Query: 581 ELQHNLQKKDADLRAMEERYRRYVD-------------------------KARMVMQTME 615
EL+ LQ++ + EER + D +AR + + +
Sbjct: 1818 ELE-ALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELA 1876
Query: 616 PKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQ 675
+ R L LR + RE++ + L+ + + E E + L +W L+
Sbjct: 1877 VEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLK 1936
Query: 676 QRAGE-ERAPAHAQSFLAQQRLA 697
+R E E A +QS Q+ A
Sbjct: 1937 ERDQELEALRAESQSSRHQEEAA 1959
Score = 77.0 bits (188), Expect = 6e-14
Identities = 120/567 (21%), Positives = 236/567 (41%), Gaps = 58/567 (10%)
Query: 180 LSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLL 239
L+ + +L+Q+ + + LL ++ +E LR+R+ + GE A + +
Sbjct: 395 LTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDT--LAGQTV 452
Query: 240 LLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDE-MD 298
LQ +++ L +E L+ RE+ R + LE+E L+ N L AQ K+E +
Sbjct: 453 DLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQE 512
Query: 299 ELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDE----LRR 354
EL + +L+ L + E +R+ E + E RQ + E L R
Sbjct: 513 ELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALAR 572
Query: 355 AGSLRAQLEAQ----RRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAE 410
A A+L + + +V +L+ + + E + L ++ + +E + + +
Sbjct: 573 AEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSR 632
Query: 411 RDSLREANEELRC----AQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQL 466
++ +A L+ A+ + L + + L+ + AE L A+LR+ +Q
Sbjct: 633 MEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAE-LQADLRD----IQE 687
Query: 467 ENKRLCRQEAADRERQEELQRHLEDANR---------ARHGLETQHRLNQQQLSELRAQV 517
E + + ++ + R +QE LE ++ AR E + + ++ E+R Q
Sbjct: 688 EKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQA 747
Query: 518 -----EDLQKALQEQGGKTEDAISILLKRKLEEHLQKLHEADLELQ-----RKREYIE-- 565
+DL + LQ E S L + + + + ++ + LE+Q + +E I+
Sbjct: 748 VERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGE 807
Query: 566 ----ELEPPTDSSTA--RRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPK-- 617
+LE T+ S A R + Q + A+E++ + + + + E +
Sbjct: 808 VRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERS 867
Query: 618 --QRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQ 675
Q+ A A L SL + E ++R++ + + E ++QRE+E SA M Q
Sbjct: 868 WHQQELAKA---LESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQM----Q 920
Query: 676 QRAGEERAPAHAQSFLAQQRLATNSRR 702
+ER Q+ LA S++
Sbjct: 921 LETEKERVSLLETLLQTQKELADASQQ 947
Score = 73.9 bits (180), Expect = 5e-13
Identities = 131/567 (23%), Positives = 239/567 (42%), Gaps = 71/567 (12%)
Query: 173 QSRRYYFLSEEAEEGDELQQRCLDLERQLM--------LLSEEKQSLAQENAGLRERMGR 224
+ R + E A+ + L++ ++LE +L + ++ ++ Q + L +
Sbjct: 863 EKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLE 922
Query: 225 PEGEGTPGL-----TAKKLLLLQSQLEQLQEENFRLESGREDE-------RLRCAELERE 272
E E L T K+L QLE+L+++ +++ +E E +L+ A+ E +
Sbjct: 923 TEKERVSLLETLLQTQKELADASQQLERLRQD-MKVQKLKEQETTGILQTQLQEAQRELK 981
Query: 273 VAELQHRNQALTSLAQEAQALKDEMDELRQSSERAGQLEATLTSCR-------RRLGELR 325
A QHR+ + + L+D+MD +Q + QL A S R +L E +
Sbjct: 982 EAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQ 1041
Query: 326 ELRRQVRQLEERNAGHAERTRQLEDE---LRRAGSLRAQ-LEAQRRQVQELQGQRQEEAM 381
E R ++LE A + E L+ A S+R Q L A R+ +QE QG+++E +
Sbjct: 1042 EYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKE--L 1099
Query: 382 KAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEELRCA-QLQPRGLTQADPSLDP 440
A+ L + ++EK ++ +LL E ++ ++LR + Q Q L
Sbjct: 1100 SAQMELLR-QEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRS 1158
Query: 441 TSTPVDNLAAEILPAELRETLLRLQLENKRLCRQEAADRERQEELQRHLE---------- 490
T + ++ LAAE P + +L L + + E + EL +
Sbjct: 1159 TESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEP 1218
Query: 491 DANRARHGLETQHRLN----QQQLSELRAQVEDLQK------ALQEQGGKTEDAISILLK 540
D N AR + L + S L +DL K L++Q K E+ ++
Sbjct: 1219 DQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEA 1278
Query: 541 RKLEEHLQKLHEADLELQRKREYIEELEPPTDS--STARRIEELQHNLQK--KDADLRAM 596
K + H + L + +L + +E + E +S S + E +LQ + A+L+ M
Sbjct: 1279 EKSQVHTE-LQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRM 1337
Query: 597 EERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVR-------IRHLEMDF 649
E + R + +A T + + AA + + E D+R +++ E++
Sbjct: 1338 EAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVES 1397
Query: 650 EKSRSQREQEEKLLISAWYNMGMALQQ 676
E+ R+Q QE+ L A G ALQ+
Sbjct: 1398 ERERAQALQEQGELKVA---QGKALQE 1421
Score = 67.4 bits (163), Expect = 4e-11
Identities = 122/588 (20%), Positives = 236/588 (40%), Gaps = 62/588 (10%)
Query: 128 KQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYFLSEEAEEG 187
+++ ++ M L+E Q MEAIQ ++ + S +++ R L +
Sbjct: 881 EREKMELEMRLKE--QQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQ 938
Query: 188 DELQQRCLDLER-----QLMLLSEEK-----QSLAQENAGLRERMGRPEGEGTPGLTAKK 237
EL LER ++ L E++ Q+ QE + R + L +
Sbjct: 939 KELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEES 998
Query: 238 LLLLQSQLE---QLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALK 294
LLQ +++ Q+++ +L + + +RL E++ ++ E Q N+ L +E +L
Sbjct: 999 SSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLT 1058
Query: 295 DEMDELRQ--------SSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTR 346
+ E Q S R +L A + GE +EL Q+ L + E
Sbjct: 1059 LSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQ------EVKE 1112
Query: 347 QLEDELRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKE- 405
+ D L + L +LEA Q+L+ + KA + R+ E + E++ E++
Sbjct: 1113 KEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQP 1172
Query: 406 --------RLLAERDSLREANEELRCAQLQPRGLTQADPS---LDPTSTPVDNLAAE--- 451
+L + +L++A + ++ + G + PS L+P +L
Sbjct: 1173 GNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPL 1232
Query: 452 --ILPAELRETLLRLQLENKRLCRQEAAD--RERQEELQRHLEDANRARHGLETQHRLNQ 507
L AE + L +L Q+ D R++ ++L+ L D + + T+ + Q
Sbjct: 1233 LTALSAEAVASALH-KLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQ 1291
Query: 508 QQLS---ELRAQVEDLQKALQEQGGKTEDAISILLKRKLEEHLQKLHEADLELQRKREYI 564
+QLS E +++ E Q +L+ + + + ++ L R LQ++ EA E + +
Sbjct: 1292 RQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRM-EAQGERELLQAAK 1350
Query: 565 EELEPPTDSSTARRIEE---------LQHNLQKKDADLRAMEERYRRYVDKARMVMQTME 615
E L + A +E L+ +L+ + L+ E ++A+ + + E
Sbjct: 1351 ENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGE 1410
Query: 616 PKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEEKLL 663
K L L L ER+ + L ++ QRE ++ L
Sbjct: 1411 LKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAAL 1458
Score = 33.1 bits (74), Expect = 0.92
Identities = 38/166 (22%), Positives = 73/166 (43%), Gaps = 12/166 (7%)
Query: 438 LDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQEAADRERQEELQRHLEDANRARH 497
++ S ++N+ + L L E +L LQ Q+ A E Q R L+++ A+
Sbjct: 1 METRSPGLNNMKPQSLQLVLEEQVLALQ--------QQMA--ENQAASWRKLKNSQEAQQ 50
Query: 498 GLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDAISILLKRKLEEHLQKLHEADLEL 557
T R Q ++ + R+ ++L+K L+ GG + + L+E L +L E
Sbjct: 51 RQATLVRKLQAKVLQYRSWCQELEKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRC 110
Query: 558 QRKREYIEELEPPTDSSTARRIEELQHNLQKKDAD-LRAMEERYRR 602
+ E +L + + + L+ +++K D RA +E R+
Sbjct: 111 ESLAEVNTQLRLHMEKADVVN-KALREDVEKLTVDWSRARDELMRK 155
Score = 31.2 bits (69), Expect = 3.5
Identities = 32/123 (26%), Positives = 53/123 (43%), Gaps = 8/123 (6%)
Query: 189 ELQQRCLDLERQLMLLSEEKQSLAQENA-----GLRERMGRPEGEGTPGLTAKKLLLLQS 243
+L+ +ER+ L E AQ + + +G G AK + LQ
Sbjct: 2295 QLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQK 2354
Query: 244 QLEQLQEENFRLESGREDERLRCAELEREVAELQHR-NQALTSLAQ--EAQALKDEMDEL 300
++ LQ + ++D R A+ RE+A L H + +L ++AQ EA L+ E L
Sbjct: 2355 EVVLLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQAPEATVLEAETRRL 2414
Query: 301 RQS 303
+S
Sbjct: 2415 DES 2417
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 95.9 bits (237), Expect = 1e-19
Identities = 131/536 (24%), Positives = 229/536 (42%), Gaps = 94/536 (17%)
Query: 233 LTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELE---------------------R 271
LT++ + + L +++EE E R +ER R AE+E R
Sbjct: 1329 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1388
Query: 272 EVAELQHRNQ--------ALTSLAQEAQALKDEMDELRQSSE-----RAGQLEATLTSCR 318
E ELQ R Q A Q+ +++++E+ +LRQSSE +A Q EA S
Sbjct: 1389 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL 1448
Query: 319 RRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRAQLEAQRRQVQE----LQG 374
R E+R +R Q+ E + G E EL+ + + EAQ+RQ QE L+
Sbjct: 1449 RIEEEIRVVRLQLEATERQRGG-------AEGELQALRARAEEAEAQKRQAQEEAERLRR 1501
Query: 375 QRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLR----EANEELRCAQLQPRG 430
Q Q+E+ + + E + + +EK+R L + LR EA LR A+++
Sbjct: 1502 QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1561
Query: 431 LTQ---------ADPSLDPTSTPVDNLAAEILPAELRE---TLLRLQLENKRLCRQEAAD 478
Q A+ L A+ L L+E + +L+ E +R +Q+A
Sbjct: 1562 QVQVALETAQRSAEAELQSKRASFAEKTAQ-LERSLQEEHVAVAQLREEAERRAQQQAEA 1620
Query: 479 RERQEELQRHLE----DANRA-RHGLETQHRLNQQQLSELRA--QVEDLQKALQEQGGKT 531
+EE +R LE AN A R L+ + Q+ L++ A Q E+ ++ + +G
Sbjct: 1621 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1680
Query: 532 EDAI--------SILLKRKL-----------EEHLQKLHEADLELQRKREYIEE----LE 568
E A+ + +R+L E+ L +L + +++R+ +EE L+
Sbjct: 1681 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1740
Query: 569 PPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPEL 628
++T +R +EL+ L K A++ + R +++R + + + AG EL
Sbjct: 1741 REAAAATQKR-QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1799
Query: 629 HSLRTQLRE-RDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERA 683
+LR + R ++ E + QR + E++L +G A + + E A
Sbjct: 1800 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1855
Score = 90.5 bits (223), Expect = 5e-18
Identities = 155/579 (26%), Positives = 245/579 (42%), Gaps = 88/579 (15%)
Query: 182 EEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTA-----K 236
+ AEE + L + LE+Q L Q+ AQ +E R + E A +
Sbjct: 1354 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ 1413
Query: 237 KLLLLQSQLEQL-------------QEENFRLESGREDERLRCAELEREVAELQHRN--- 280
+ +Q +L+QL Q E R +E +R L+ E E Q
Sbjct: 1414 QKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1473
Query: 281 --QALTSLAQEAQALK----DEMDELRQ----SSERAGQLEATLTSCRRRLGE-LRELRR 329
QAL + A+EA+A K +E + LR+ S+R Q E L S + E RE +R
Sbjct: 1474 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1533
Query: 330 QVRQLEERNAGHAERTRQL-EDELRRAGSLRAQLE-AQRRQVQELQGQRQEEAMKAEKWL 387
++ LEE E R+L + E+ RA ++ LE AQR ELQ +R A AEK
Sbjct: 1534 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR---ASFAEKTA 1590
Query: 388 FECRNLEEKYESVTKEKERLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDN 447
R+L+E++ +V + +E AER + ++A E R +A+ L+ +
Sbjct: 1591 QLERSLQEEHVAVAQLREE--AERRAQQQAEAE--------RAREEAERELERWQLKANE 1640
Query: 448 LAAEILPAE---LRETLLRLQLENKRLCRQEAADRE------------RQEEL-QRHLED 491
L AE +++L + + E ++ E A+RE RQ EL ++ LE
Sbjct: 1641 ALRLRLQAEEVAQQKSLAQAEAEKQK----EEAEREARRRGKAEEQAVRQRELAEQELEK 1696
Query: 492 ANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDAISILLKRKLEEHLQKLH 551
+ G Q +Q+L LRA+ E EQ + + L+R+ QK
Sbjct: 1697 QRQLAEGTAQQRLAAEQELIRLRAETEQ-----GEQQRQLLEEELARLQREAAAATQKRQ 1751
Query: 552 EADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVM 611
E + EL + R +E L +S AR EE + +K L A R+R ++A +
Sbjct: 1752 ELEAELAKVRAEMEVLL----ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1807
Query: 612 QTMEPKQRPAAGAPPELHSLRTQ----LRERDVRI---RHLEMDFEKSRSQREQEEKLLI 664
E +R A + R + L E+ I L+ + E + ++E E + L
Sbjct: 1808 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLR 1867
Query: 665 SAWYNMGMALQQRAGEERAPAH---AQSFLAQQRLATNS 700
+ A Q+R EE+A H + LAQ R A++S
Sbjct: 1868 RLAED--EAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1904
Score = 88.6 bits (218), Expect = 2e-17
Identities = 134/541 (24%), Positives = 226/541 (41%), Gaps = 71/541 (13%)
Query: 180 LSEEAEEGDE----LQQRCLDLERQLMLLSEEKQSLAQENAGLRERM---------GRPE 226
L E E+G++ L++ L+R+ ++++Q L E A +R M E
Sbjct: 1718 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1777
Query: 227 GEGTPGLTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAE---LQHRNQAL 283
T + ++L + +L EE RL + E+ A+ +R++AE + R +A
Sbjct: 1778 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE-----AKRQRQLAEEDAARQRAEAE 1832
Query: 284 TSLAQEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHA- 342
LA++ A+ E L+ +E A + + RRL E +R R+LEE+ A H
Sbjct: 1833 RVLAEKLAAI-GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR--RRLEEQAAQHKA 1889
Query: 343 ---ERTRQL----EDELRRAGSLRAQLEAQRRQVQE----LQGQRQEEAMKAEKWLFECR 391
ER QL + EL R L QRRQV+E L+ ++ A + E
Sbjct: 1890 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1949
Query: 392 NLEEKYESVTKEKER--LLAERDSLREANEELRCAQLQPR------GLTQADPSLDPTST 443
+ E + KE+ L A R A EE R + + R +A
Sbjct: 1950 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2009
Query: 444 PVDNLAAEILPAELRETLLRLQLENKRLCR--QEAADRERQEELQRHLEDANRARHGLET 501
V+ L A++ E R R + E+ R + QEAA + Q E + H + L+
Sbjct: 2010 EVERLKAKV--EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2067
Query: 502 QHRLNQQQLSELRAQVEDLQKALQE-QGGKTEDAISILLKRKLEEHLQKLHEADLELQRK 560
+ Q L +LR + E ++A +E + + + R+ E ++L ++ E +
Sbjct: 2068 TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2127
Query: 561 REY----IEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEP 616
R E+L + ARR + Q L++K A A E+++++ + QT+
Sbjct: 2128 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA-ADAEMEKHKKFAE------QTLRQ 2180
Query: 617 KQRPAAGAPPELHSLRTQLRER-------DVRIRHLEMDFEKSRSQREQEEKLLISAWYN 669
K A EL +LR QL E D ++ L+ + ++ QR Q E+ L S
Sbjct: 2181 K----AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2236
Query: 670 M 670
M
Sbjct: 2237 M 2237
Score = 83.6 bits (205), Expect = 6e-16
Identities = 143/554 (25%), Positives = 223/554 (40%), Gaps = 76/554 (13%)
Query: 188 DELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQSQLEQ 247
+EL+ + + ER+L E+ Q +R E + A+K L+
Sbjct: 1539 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE---RS 1595
Query: 248 LQEENFRLESGREDERLRC---AELEREVAELQHRNQALTSLAQEAQALKDEMDELRQ-- 302
LQEE+ + RE+ R AE ER E + + A EA L+ + +E+ Q
Sbjct: 1596 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1655
Query: 303 ---SSERAGQLEATLTSCRRRLGELRELRRQVRQLEERN--------AGHAERTRQLEDE 351
+E Q E RRR G+ E + R+L E+ G A++ E E
Sbjct: 1656 SLAQAEAEKQKEEAEREARRR-GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1714
Query: 352 LRRAGSLRAQLEAQRRQVQELQGQRQEEA----------------MKAEKWLF---ECRN 392
L R + Q E QR+ ++E + Q EA ++AE + + R
Sbjct: 1715 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1774
Query: 393 LEEKYESVTKEKERLLAERDSLREANEE---LRC-AQLQPRGLTQADPSLDPTSTPVDNL 448
EE + K K+RL AE RE EE LR A+ R A+ + +
Sbjct: 1775 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1834
Query: 449 AAEILPAELRETLLRLQLENKRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQ 508
AE L A T RL+ E + +++ A+ ER L+R ED R LE Q ++
Sbjct: 1835 LAEKLAAIGEAT--RLKTEAEIALKEKEAENER---LRRLAEDEAFQRRRLEEQAAQHKA 1889
Query: 509 QLSELRAQVEDLQKA-LQEQGGKTEDAIS---------ILLKRKLEEHLQKLHEADLELQ 558
+ E AQ+ + L+ Q G ED + + LK E+ E +LEL
Sbjct: 1890 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1949
Query: 559 RKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYV-DKARMVMQTMEPK 617
R R E D+ ++ EL+ Q++ L A EER RR ++ + + E
Sbjct: 1950 RIRSNAE------DTLRSKEQAELEAARQRQ---LAAEEERRRREAEERVQKSLAAEEEA 2000
Query: 618 QRPAAGAPPELHSLRT------QLRER--DVRIRHLEMDFEKSRSQREQEEKLLISAWYN 669
R A E+ L+ +LRER R L++ E ++ + + EEK A
Sbjct: 2001 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2060
Query: 670 MGMALQQRAGEERA 683
LQQ +E++
Sbjct: 2061 KEQELQQTLQQEQS 2074
Score = 80.9 bits (198), Expect = 4e-15
Identities = 143/623 (22%), Positives = 255/623 (40%), Gaps = 97/623 (15%)
Query: 133 QRIMTLEESVQHVVMEAIQELM-TKDTPDSLSPETYGNFDSQSRRYYFLSEEAEEGD--- 188
+R+ E++ V + QEL T S+ + G ++ R +EEAEE
Sbjct: 2045 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA----AEEAEEARVQA 2100
Query: 189 -----ELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQS 243
+ +++ + ER E+ Q+ AQ A + E E A++ L Q
Sbjct: 2101 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2160
Query: 244 QL--------EQLQEENFRLESGREDE----RLRCAELEREV----AELQHRNQALTSLA 287
Q ++ E+ R ++ E E RL+ E + + ELQ T A
Sbjct: 2161 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAA 2220
Query: 288 QEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQ 347
++ +++E+ +R E +L+A + + R L LR+ R L+E AE+ +Q
Sbjct: 2221 RQRSQVEEELFSVRVQMEELSKLKARIEAENRAL-ILRDKDNTQRFLQEE----AEKMKQ 2275
Query: 348 LEDELRRAGSLRAQLEAQRRQVQE------------LQGQRQEEAMKAEKWLFECRNLEE 395
+ +E R S+ AQ A+ RQ+ E + ++ + +A + E L++
Sbjct: 2276 VAEEAARL-SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2334
Query: 396 KYESVTKEKERLLAERDSL-REANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILP 454
+ E ++ RL +++ + ++ EE + Q Q + + + AE+
Sbjct: 2335 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2394
Query: 455 AELRET----LLRLQLEN--KRLCRQEAADRERQE-----ELQRHLED--ANRARHG--- 498
A+ R R Q E ++L R E A +E+ E+QR D A R R
Sbjct: 2395 AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2454
Query: 499 LETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDAISILLKRKLEEHLQKLHEADLELQ 558
LE + QQ+ L+ + E++Q QEQ LL+ L E D LQ
Sbjct: 2455 LEREKEKLQQEAKLLQLKSEEMQTVQQEQ----------LLQETQALQQSFLSEKDSLLQ 2504
Query: 559 RKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQ 618
R+R +IE+ ++E+L + K LR ++R ++ +++ R Q
Sbjct: 2505 RER-FIEQ--------EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQER---------Q 2546
Query: 619 RPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRA 678
R A + R + E + +R + + ++ QR Q+E+LL + LQ
Sbjct: 2547 RLVA----SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2602
Query: 679 GEERAP-AHAQSFLAQQRLATNS 700
+ RA AH++ A Q AT +
Sbjct: 2603 EQHRAALAHSEEVTASQVAATKT 2625
Score = 80.1 bits (196), Expect = 7e-15
Identities = 115/545 (21%), Positives = 226/545 (41%), Gaps = 44/545 (8%)
Query: 183 EAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQ 242
+ E E QR + ++ + + +A+ +A + + PE +L L
Sbjct: 1012 DKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTL 1071
Query: 243 SQLEQLQEENFRLESGREDERLRCAELE-REVAELQHRNQALTSLAQEAQALKDEMDELR 301
+LEQ+ R S E+L+ L R + +A +EAQA+ + EL
Sbjct: 1072 GKLEQV-----RSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELE 1126
Query: 302 QSSERAGQLEATLTSCRRRLGELRELRRQVRQLEER-NAGHAERTRQLE-------DELR 353
+ +L A + + LR+ R +++ ER H ER ++E L
Sbjct: 1127 ATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLE 1186
Query: 354 RAGSLRAQLEAQRRQVQELQGQ---RQEEAMKAEKWLFECRNLEEKYESV-----TKEKE 405
R ++ AQ + ++R++++L Q +E A WL + R +E+ +++ +E
Sbjct: 1187 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1246
Query: 406 RLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQ 465
+L E+ L E + R Q ++ + A++ P ++Q
Sbjct: 1247 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQ 1306
Query: 466 LENKRLCRQEAADRERQEEL----QRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQ 521
++ + ++ R EL ++++ + +E + RL +QQ +E R ++ +++
Sbjct: 1307 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1366
Query: 522 KALQEQGGKTE---------DAISILLKRKLEEHLQKLHEADLEL-QRKREYIEELEPPT 571
AL++Q E + + L+++++E + + EA ++ Q+KR EEL+
Sbjct: 1367 AALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR 1426
Query: 572 DSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSL 631
SS A +Q K A E R ++ R+V +E +R GA EL +L
Sbjct: 1427 QSSEA--------EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1478
Query: 632 RTQLRERDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFL 691
R + E + + R + + E+ R Q + E + A + ++ A R A L
Sbjct: 1479 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL 1538
Query: 692 AQQRL 696
+ RL
Sbjct: 1539 EELRL 1543
Score = 79.0 bits (193), Expect = 1e-14
Identities = 144/643 (22%), Positives = 255/643 (39%), Gaps = 85/643 (13%)
Query: 126 EKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYFLSEEAE 185
E D Q+ +++E +Q + + E+ K + + + + R E E
Sbjct: 1406 EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE 1465
Query: 186 ------EGD--ELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKK 237
EG+ L+ R + E Q EE + L ++ +R + E E + A+
Sbjct: 1466 RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEA 1525
Query: 238 LLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEM 297
+ Q E RL++ + RLR AE+ER Q +L ++ + E+
Sbjct: 1526 EAAREKQRALQALEELRLQAEEAERRLRQAEVER-------ARQVQVALETAQRSAEAEL 1578
Query: 298 DELRQS-SERAGQLEATLTSCRRRLGELR-ELRRQVRQLEERNAGHAERTRQLED-ELRR 354
R S +E+ QLE +L + +LR E R+ +Q E E R+LE +L+
Sbjct: 1579 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1638
Query: 355 AGSLRAQLE----AQRRQVQELQGQRQEEAM--------KAEKWLFECRNLEEKYESVTK 402
+LR +L+ AQ++ + + + ++Q+E KAE+ R L E+
Sbjct: 1639 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ----EL 1694
Query: 403 EKERLLAERDSLREANEELRCAQL--------QPRGLTQADPSLDPTSTPVDNLAAEILP 454
EK+R LAE + + E +L Q R L + + + + L
Sbjct: 1695 EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1754
Query: 455 AELRETLLRLQLENKRLCRQEAADRERQEELQRHLE-DANRARHGLETQHRL-------- 505
AEL + +++ R E R E+ ++ LE +A R R E RL
Sbjct: 1755 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1814
Query: 506 NQQQLSELRA--QVEDLQKALQEQGG--------KTEDAISILLKRKLEEHLQKLHEADL 555
Q+QL+E A Q + ++ L E+ KTE I++ K E L++L E D
Sbjct: 1815 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE-DE 1873
Query: 556 ELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTME 615
QR+R +EE + R+ +L+ + D++L ER + V+ + +E
Sbjct: 1874 AFQRRR--LEEQAAQHKADIEERLAQLR---KASDSEL----ERQKGLVEDTLRQRRQVE 1924
Query: 616 PKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQRE----QEEKLLISAWYNMG 671
E+ +L+ + LE++ + RS E +E+ + A
Sbjct: 1925 ----------EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ 1974
Query: 672 MALQQRAGEERAPAHAQSFLAQQRLATNSRRGPLGRLASLNLR 714
+A ++ A Q LA + A R+ L + L +
Sbjct: 1975 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2017
Score = 70.9 bits (172), Expect = 4e-12
Identities = 114/468 (24%), Positives = 195/468 (41%), Gaps = 62/468 (13%)
Query: 181 SEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLL 240
+E A + ++++ + Q+ LS+ K + EN L R T + L
Sbjct: 2217 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR--------DKDNTQRFLQE 2268
Query: 241 LQSQLEQLQEENFRLE-SGREDERLRCAELE-----REVAE--LQHRNQALTSLAQEAQA 292
+++Q+ EE RL + +E RLR E R +AE L+ + QA+ QEA
Sbjct: 2269 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAV----QEATR 2324
Query: 293 LKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDEL 352
LK E + L+Q E A + RRL E +E + +QL E G R LE E
Sbjct: 2325 LKAEAELLQQQKELAQEQA-------RRLQEDKE--QMAQQLAEETQGFQ---RTLEAER 2372
Query: 353 RRAGSLRAQLEAQRRQVQEL---QGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLA 409
+R + A+ E + +V E+ Q + +E+A + K E + E T+EK L+
Sbjct: 2373 QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2432
Query: 410 ERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENK 469
+ R+ Q+D + + L E + LL+L+ E
Sbjct: 2433 TLEIQRQ----------------QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2476
Query: 470 RLCRQEAADRERQEELQRHLEDAN---RARHGLETQHRLNQQQLSELRAQVEDLQKALQE 526
+ +QE +E Q Q L + + + +E + +Q + A+ + L++ Q
Sbjct: 2477 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2536
Query: 527 QGGKTEDAISILLKRKLEEHLQKLHEADLELQRKREYIEELEPPT---DSSTARRIEELQ 583
Q + E L+ +EE ++ HEA+ ++RK+E +++LE + A + L+
Sbjct: 2537 QQQQMEQERQRLVA-SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2595
Query: 584 HNLQKKDADLRAM----EERYRRYVDKARMVMQTMEPKQRPAAGAPPE 627
LQ + RA EE V + + + PAA A PE
Sbjct: 2596 EQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2643
Score = 54.3 bits (129), Expect = 4e-07
Identities = 100/471 (21%), Positives = 180/471 (38%), Gaps = 97/471 (20%)
Query: 299 ELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERN-------------------- 338
+L QS E+ Q E+ C+R + EL+++R Q+ E R
Sbjct: 967 QLLQSLEQGAQEESR---CQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRI 1023
Query: 339 --------------------AGHAERTRQLEDELRRAGSLRAQLEAQRRQVQELQG---- 374
+ AE+ L + A +LR++LE ++++++
Sbjct: 1024 AEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1083
Query: 375 ---------------QRQEEAMKA-EKWLFECR-------NLEEKYESVTKEKERLLAER 411
Q EE ++A E+ L E + LE S+ K + + A++
Sbjct: 1084 YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQ 1143
Query: 412 DSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEIL---PAELRETLLRLQLEN 468
+ +ELR AQ L Q D A++L A L +T +R Q E
Sbjct: 1144 PTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVR-QREL 1202
Query: 469 KRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQG 528
++L RQ RE + L L+DA R + ++ + Q + E Q + L + ++ G
Sbjct: 1203 EQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHG 1262
Query: 529 GKTEDAISILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQK 588
K E+ +R ++++ + + +L+L Y +LEP + +++ ++ +
Sbjct: 1263 EKVEEC-----QRFAKQYINAIKDYELQLV---TYKAQLEPVASPAKKPKVQSGSESVIQ 1314
Query: 589 KDADLRA----MEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRH 644
+ DLR + +Y+ ++ ME ++R A Q E R+
Sbjct: 1315 EYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLA----------EQQRAEERERLAE 1364
Query: 645 LEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQR 695
+E EK R E + A LQQR EE + AQQ+
Sbjct: 1365 VEAALEKQRQLAEAHAQAKAQA-EREAKELQQRMQEEVVRREEAAVDAQQQ 1414
Score = 49.3 bits (116), Expect = 1e-05
Identities = 87/378 (23%), Positives = 152/378 (40%), Gaps = 90/378 (23%)
Query: 162 LSPETYG---NFDSQSRRYYFLSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGL 218
L+ ET G +++ +R +S EAE L+ R ++ R E+ Q ++ +
Sbjct: 2357 LAEETQGFQRTLEAERQRQLEMSAEAER---LKLRVAEMSRAQARAEEDAQRFRKQAEEI 2413
Query: 219 RERMGRPEGEGTPGLTAKKLLLLQSQLEQLQEENFRLESGREDERLR--CAELEREVAEL 276
E++ R E T +K+ L+Q+ Q Q+ S + ERLR AELERE +L
Sbjct: 2414 GEKLHRTELA-----TQEKVTLVQTLEIQRQQ------SDHDAERLREAIAELEREKEKL 2462
Query: 277 QHRNQALT------------SLAQEAQALK-----------------------------D 295
Q + L L QE QAL+ D
Sbjct: 2463 QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2522
Query: 296 EMDELRQSSERAGQLEATLTSCRRRL-GELRELRRQVRQLEERNAGHAERTRQLEDELRR 354
E+ + +Q E + + + R+RL + E RR+ + E E R+ ++EL+
Sbjct: 2523 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE-------EGVRRKQEELQ- 2574
Query: 355 AGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSL 414
QLE QRRQ +EL + + + + + LEE++ + E + A + +
Sbjct: 2575 ------QLEQQRRQQEELLAEENQRLRE------QLQLLEEQHRAALAHSEEVTASQVAA 2622
Query: 415 REANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQ 474
+ R A P + + S D L ++ L+E + E +RL +
Sbjct: 2623 TKTLPNGRDALDGPAAEAEPEHSF-------DGLRRKVSAQRLQEAGILSAEELQRLAQG 2675
Query: 475 EAADRE--RQEELQRHLE 490
E R+E+++ +L+
Sbjct: 2676 HTTVDELARREDVRHYLQ 2693
Score = 33.1 bits (74), Expect = 0.92
Identities = 105/481 (21%), Positives = 182/481 (37%), Gaps = 60/481 (12%)
Query: 177 YYFLSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAK 236
Y+ L E E G +L L+ E+QL E + L + L+ G
Sbjct: 361 YHPLDVEKEWG-KLHVAILEREKQLRSEFERLECLQRIVTKLQMEAG------------- 406
Query: 237 KLLLLQSQLEQ----LQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQA 292
L + QL Q LQ + L +G+ +R E+ER+ L + + L + Q
Sbjct: 407 ---LCEEQLNQADALLQSDVRLLAAGKVPQR--AGEVERD---LDKADSMIRLLFNDVQT 458
Query: 293 LKD-EMDELRQSSERAGQLEATLTSCRRR--LGELRELRRQVRQLEERNAGHAERTRQLE 349
LKD + Q R +L L + R L + Q+ + +R +LE
Sbjct: 459 LKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELE 518
Query: 350 DE-LRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLL 408
D LR L A +E + +V + +++A+ L R L + E + ER
Sbjct: 519 DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQ--LGSHRGLHQSIEEFRAKIERAR 576
Query: 409 AERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAA--EILPAELRETLLRLQL 466
++ L A L L A L+ + + +L + + A +E + +
Sbjct: 577 SDEGQLSPATRGAYRDCLGRLDLQYAK-LLNSSKARLRSLESLHSFVAAATKELMWLNEK 635
Query: 467 ENKRLC-------RQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVED 519
E + + A +E L R LE + L+ ++ R VE
Sbjct: 636 EEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVES 695
Query: 520 LQKALQEQGGKTEDAISILLKRKLEEHLQK----------LHEADLELQRKREYIEELEP 569
Q ALQ T+ + + L +E HL++ + EA+ +LQ+ +E +
Sbjct: 696 FQAALQ-----TQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYS 750
Query: 570 PTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQ--RPAAGAPPE 627
S+T R+E+L + Q + L + +A+ V+Q ++P+ P G P
Sbjct: 751 CDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQ-LKPRHPAHPMRGRLPL 809
Query: 628 L 628
L
Sbjct: 810 L 810
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 95.9 bits (237), Expect = 1e-19
Identities = 131/536 (24%), Positives = 229/536 (42%), Gaps = 94/536 (17%)
Query: 233 LTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELE---------------------R 271
LT++ + + L +++EE E R +ER R AE+E R
Sbjct: 1333 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1392
Query: 272 EVAELQHRNQ--------ALTSLAQEAQALKDEMDELRQSSE-----RAGQLEATLTSCR 318
E ELQ R Q A Q+ +++++E+ +LRQSSE +A Q EA S
Sbjct: 1393 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL 1452
Query: 319 RRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRAQLEAQRRQVQE----LQG 374
R E+R +R Q+ E + G E EL+ + + EAQ+RQ QE L+
Sbjct: 1453 RIEEEIRVVRLQLEATERQRGG-------AEGELQALRARAEEAEAQKRQAQEEAERLRR 1505
Query: 375 QRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLR----EANEELRCAQLQPRG 430
Q Q+E+ + + E + + +EK+R L + LR EA LR A+++
Sbjct: 1506 QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1565
Query: 431 LTQ---------ADPSLDPTSTPVDNLAAEILPAELRE---TLLRLQLENKRLCRQEAAD 478
Q A+ L A+ L L+E + +L+ E +R +Q+A
Sbjct: 1566 QVQVALETAQRSAEAELQSKRASFAEKTAQ-LERSLQEEHVAVAQLREEAERRAQQQAEA 1624
Query: 479 RERQEELQRHLE----DANRA-RHGLETQHRLNQQQLSELRA--QVEDLQKALQEQGGKT 531
+EE +R LE AN A R L+ + Q+ L++ A Q E+ ++ + +G
Sbjct: 1625 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1684
Query: 532 EDAI--------SILLKRKL-----------EEHLQKLHEADLELQRKREYIEE----LE 568
E A+ + +R+L E+ L +L + +++R+ +EE L+
Sbjct: 1685 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1744
Query: 569 PPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPEL 628
++T +R +EL+ L K A++ + R +++R + + + AG EL
Sbjct: 1745 REAAAATQKR-QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1803
Query: 629 HSLRTQLRE-RDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERA 683
+LR + R ++ E + QR + E++L +G A + + E A
Sbjct: 1804 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1859
Score = 90.5 bits (223), Expect = 5e-18
Identities = 155/579 (26%), Positives = 245/579 (42%), Gaps = 88/579 (15%)
Query: 182 EEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTA-----K 236
+ AEE + L + LE+Q L Q+ AQ +E R + E A +
Sbjct: 1358 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ 1417
Query: 237 KLLLLQSQLEQL-------------QEENFRLESGREDERLRCAELEREVAELQHRN--- 280
+ +Q +L+QL Q E R +E +R L+ E E Q
Sbjct: 1418 QKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1477
Query: 281 --QALTSLAQEAQALK----DEMDELRQ----SSERAGQLEATLTSCRRRLGE-LRELRR 329
QAL + A+EA+A K +E + LR+ S+R Q E L S + E RE +R
Sbjct: 1478 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1537
Query: 330 QVRQLEERNAGHAERTRQL-EDELRRAGSLRAQLE-AQRRQVQELQGQRQEEAMKAEKWL 387
++ LEE E R+L + E+ RA ++ LE AQR ELQ +R A AEK
Sbjct: 1538 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR---ASFAEKTA 1594
Query: 388 FECRNLEEKYESVTKEKERLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDN 447
R+L+E++ +V + +E AER + ++A E R +A+ L+ +
Sbjct: 1595 QLERSLQEEHVAVAQLREE--AERRAQQQAEAE--------RAREEAERELERWQLKANE 1644
Query: 448 LAAEILPAE---LRETLLRLQLENKRLCRQEAADRE------------RQEEL-QRHLED 491
L AE +++L + + E ++ E A+RE RQ EL ++ LE
Sbjct: 1645 ALRLRLQAEEVAQQKSLAQAEAEKQK----EEAEREARRRGKAEEQAVRQRELAEQELEK 1700
Query: 492 ANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDAISILLKRKLEEHLQKLH 551
+ G Q +Q+L LRA+ E EQ + + L+R+ QK
Sbjct: 1701 QRQLAEGTAQQRLAAEQELIRLRAETEQ-----GEQQRQLLEEELARLQREAAAATQKRQ 1755
Query: 552 EADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVM 611
E + EL + R +E L +S AR EE + +K L A R+R ++A +
Sbjct: 1756 ELEAELAKVRAEMEVLL----ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1811
Query: 612 QTMEPKQRPAAGAPPELHSLRTQ----LRERDVRI---RHLEMDFEKSRSQREQEEKLLI 664
E +R A + R + L E+ I L+ + E + ++E E + L
Sbjct: 1812 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLR 1871
Query: 665 SAWYNMGMALQQRAGEERAPAH---AQSFLAQQRLATNS 700
+ A Q+R EE+A H + LAQ R A++S
Sbjct: 1872 RLAED--EAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1908
Score = 88.6 bits (218), Expect = 2e-17
Identities = 134/541 (24%), Positives = 226/541 (41%), Gaps = 71/541 (13%)
Query: 180 LSEEAEEGDE----LQQRCLDLERQLMLLSEEKQSLAQENAGLRERM---------GRPE 226
L E E+G++ L++ L+R+ ++++Q L E A +R M E
Sbjct: 1722 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1781
Query: 227 GEGTPGLTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAE---LQHRNQAL 283
T + ++L + +L EE RL + E+ A+ +R++AE + R +A
Sbjct: 1782 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE-----AKRQRQLAEEDAARQRAEAE 1836
Query: 284 TSLAQEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHA- 342
LA++ A+ E L+ +E A + + RRL E +R R+LEE+ A H
Sbjct: 1837 RVLAEKLAAI-GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR--RRLEEQAAQHKA 1893
Query: 343 ---ERTRQL----EDELRRAGSLRAQLEAQRRQVQE----LQGQRQEEAMKAEKWLFECR 391
ER QL + EL R L QRRQV+E L+ ++ A + E
Sbjct: 1894 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1953
Query: 392 NLEEKYESVTKEKER--LLAERDSLREANEELRCAQLQPR------GLTQADPSLDPTST 443
+ E + KE+ L A R A EE R + + R +A
Sbjct: 1954 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2013
Query: 444 PVDNLAAEILPAELRETLLRLQLENKRLCR--QEAADRERQEELQRHLEDANRARHGLET 501
V+ L A++ E R R + E+ R + QEAA + Q E + H + L+
Sbjct: 2014 EVERLKAKV--EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2071
Query: 502 QHRLNQQQLSELRAQVEDLQKALQE-QGGKTEDAISILLKRKLEEHLQKLHEADLELQRK 560
+ Q L +LR + E ++A +E + + + R+ E ++L ++ E +
Sbjct: 2072 TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2131
Query: 561 REY----IEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEP 616
R E+L + ARR + Q L++K A A E+++++ + QT+
Sbjct: 2132 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA-ADAEMEKHKKFAE------QTLRQ 2184
Query: 617 KQRPAAGAPPELHSLRTQLRER-------DVRIRHLEMDFEKSRSQREQEEKLLISAWYN 669
K A EL +LR QL E D ++ L+ + ++ QR Q E+ L S
Sbjct: 2185 K----AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2240
Query: 670 M 670
M
Sbjct: 2241 M 2241
Score = 83.6 bits (205), Expect = 6e-16
Identities = 143/554 (25%), Positives = 223/554 (40%), Gaps = 76/554 (13%)
Query: 188 DELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQSQLEQ 247
+EL+ + + ER+L E+ Q +R E + A+K L+
Sbjct: 1543 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE---RS 1599
Query: 248 LQEENFRLESGREDERLRC---AELEREVAELQHRNQALTSLAQEAQALKDEMDELRQ-- 302
LQEE+ + RE+ R AE ER E + + A EA L+ + +E+ Q
Sbjct: 1600 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1659
Query: 303 ---SSERAGQLEATLTSCRRRLGELRELRRQVRQLEERN--------AGHAERTRQLEDE 351
+E Q E RRR G+ E + R+L E+ G A++ E E
Sbjct: 1660 SLAQAEAEKQKEEAEREARRR-GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1718
Query: 352 LRRAGSLRAQLEAQRRQVQELQGQRQEEA----------------MKAEKWLF---ECRN 392
L R + Q E QR+ ++E + Q EA ++AE + + R
Sbjct: 1719 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1778
Query: 393 LEEKYESVTKEKERLLAERDSLREANEE---LRC-AQLQPRGLTQADPSLDPTSTPVDNL 448
EE + K K+RL AE RE EE LR A+ R A+ + +
Sbjct: 1779 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1838
Query: 449 AAEILPAELRETLLRLQLENKRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQ 508
AE L A T RL+ E + +++ A+ ER L+R ED R LE Q ++
Sbjct: 1839 LAEKLAAIGEAT--RLKTEAEIALKEKEAENER---LRRLAEDEAFQRRRLEEQAAQHKA 1893
Query: 509 QLSELRAQVEDLQKA-LQEQGGKTEDAIS---------ILLKRKLEEHLQKLHEADLELQ 558
+ E AQ+ + L+ Q G ED + + LK E+ E +LEL
Sbjct: 1894 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1953
Query: 559 RKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYV-DKARMVMQTMEPK 617
R R E D+ ++ EL+ Q++ L A EER RR ++ + + E
Sbjct: 1954 RIRSNAE------DTLRSKEQAELEAARQRQ---LAAEEERRRREAEERVQKSLAAEEEA 2004
Query: 618 QRPAAGAPPELHSLRT------QLRER--DVRIRHLEMDFEKSRSQREQEEKLLISAWYN 669
R A E+ L+ +LRER R L++ E ++ + + EEK A
Sbjct: 2005 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2064
Query: 670 MGMALQQRAGEERA 683
LQQ +E++
Sbjct: 2065 KEQELQQTLQQEQS 2078
Score = 80.9 bits (198), Expect = 4e-15
Identities = 143/623 (22%), Positives = 255/623 (40%), Gaps = 97/623 (15%)
Query: 133 QRIMTLEESVQHVVMEAIQELM-TKDTPDSLSPETYGNFDSQSRRYYFLSEEAEEGD--- 188
+R+ E++ V + QEL T S+ + G ++ R +EEAEE
Sbjct: 2049 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA----AEEAEEARVQA 2104
Query: 189 -----ELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQS 243
+ +++ + ER E+ Q+ AQ A + E E A++ L Q
Sbjct: 2105 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2164
Query: 244 QL--------EQLQEENFRLESGREDE----RLRCAELEREV----AELQHRNQALTSLA 287
Q ++ E+ R ++ E E RL+ E + + ELQ T A
Sbjct: 2165 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAA 2224
Query: 288 QEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQ 347
++ +++E+ +R E +L+A + + R L LR+ R L+E AE+ +Q
Sbjct: 2225 RQRSQVEEELFSVRVQMEELSKLKARIEAENRAL-ILRDKDNTQRFLQEE----AEKMKQ 2279
Query: 348 LEDELRRAGSLRAQLEAQRRQVQE------------LQGQRQEEAMKAEKWLFECRNLEE 395
+ +E R S+ AQ A+ RQ+ E + ++ + +A + E L++
Sbjct: 2280 VAEEAARL-SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2338
Query: 396 KYESVTKEKERLLAERDSL-REANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILP 454
+ E ++ RL +++ + ++ EE + Q Q + + + AE+
Sbjct: 2339 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2398
Query: 455 AELRET----LLRLQLEN--KRLCRQEAADRERQE-----ELQRHLED--ANRARHG--- 498
A+ R R Q E ++L R E A +E+ E+QR D A R R
Sbjct: 2399 AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2458
Query: 499 LETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDAISILLKRKLEEHLQKLHEADLELQ 558
LE + QQ+ L+ + E++Q QEQ LL+ L E D LQ
Sbjct: 2459 LEREKEKLQQEAKLLQLKSEEMQTVQQEQ----------LLQETQALQQSFLSEKDSLLQ 2508
Query: 559 RKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQ 618
R+R +IE+ ++E+L + K LR ++R ++ +++ R Q
Sbjct: 2509 RER-FIEQ--------EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQER---------Q 2550
Query: 619 RPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRA 678
R A + R + E + +R + + ++ QR Q+E+LL + LQ
Sbjct: 2551 RLVA----SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2606
Query: 679 GEERAP-AHAQSFLAQQRLATNS 700
+ RA AH++ A Q AT +
Sbjct: 2607 EQHRAALAHSEEVTASQVAATKT 2629
Score = 80.1 bits (196), Expect = 7e-15
Identities = 115/545 (21%), Positives = 226/545 (41%), Gaps = 44/545 (8%)
Query: 183 EAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQ 242
+ E E QR + ++ + + +A+ +A + + PE +L L
Sbjct: 1016 DKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTL 1075
Query: 243 SQLEQLQEENFRLESGREDERLRCAELE-REVAELQHRNQALTSLAQEAQALKDEMDELR 301
+LEQ+ R S E+L+ L R + +A +EAQA+ + EL
Sbjct: 1076 GKLEQV-----RSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELE 1130
Query: 302 QSSERAGQLEATLTSCRRRLGELRELRRQVRQLEER-NAGHAERTRQLE-------DELR 353
+ +L A + + LR+ R +++ ER H ER ++E L
Sbjct: 1131 ATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLE 1190
Query: 354 RAGSLRAQLEAQRRQVQELQGQ---RQEEAMKAEKWLFECRNLEEKYESV-----TKEKE 405
R ++ AQ + ++R++++L Q +E A WL + R +E+ +++ +E
Sbjct: 1191 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1250
Query: 406 RLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQ 465
+L E+ L E + R Q ++ + A++ P ++Q
Sbjct: 1251 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQ 1310
Query: 466 LENKRLCRQEAADRERQEEL----QRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQ 521
++ + ++ R EL ++++ + +E + RL +QQ +E R ++ +++
Sbjct: 1311 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1370
Query: 522 KALQEQGGKTE---------DAISILLKRKLEEHLQKLHEADLEL-QRKREYIEELEPPT 571
AL++Q E + + L+++++E + + EA ++ Q+KR EEL+
Sbjct: 1371 AALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR 1430
Query: 572 DSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSL 631
SS A +Q K A E R ++ R+V +E +R GA EL +L
Sbjct: 1431 QSSEA--------EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1482
Query: 632 RTQLRERDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFL 691
R + E + + R + + E+ R Q + E + A + ++ A R A L
Sbjct: 1483 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL 1542
Query: 692 AQQRL 696
+ RL
Sbjct: 1543 EELRL 1547
Score = 79.0 bits (193), Expect = 1e-14
Identities = 144/643 (22%), Positives = 255/643 (39%), Gaps = 85/643 (13%)
Query: 126 EKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYFLSEEAE 185
E D Q+ +++E +Q + + E+ K + + + + R E E
Sbjct: 1410 EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE 1469
Query: 186 ------EGD--ELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKK 237
EG+ L+ R + E Q EE + L ++ +R + E E + A+
Sbjct: 1470 RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEA 1529
Query: 238 LLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEM 297
+ Q E RL++ + RLR AE+ER Q +L ++ + E+
Sbjct: 1530 EAAREKQRALQALEELRLQAEEAERRLRQAEVER-------ARQVQVALETAQRSAEAEL 1582
Query: 298 DELRQS-SERAGQLEATLTSCRRRLGELR-ELRRQVRQLEERNAGHAERTRQLED-ELRR 354
R S +E+ QLE +L + +LR E R+ +Q E E R+LE +L+
Sbjct: 1583 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1642
Query: 355 AGSLRAQLE----AQRRQVQELQGQRQEEAM--------KAEKWLFECRNLEEKYESVTK 402
+LR +L+ AQ++ + + + ++Q+E KAE+ R L E+
Sbjct: 1643 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ----EL 1698
Query: 403 EKERLLAERDSLREANEELRCAQL--------QPRGLTQADPSLDPTSTPVDNLAAEILP 454
EK+R LAE + + E +L Q R L + + + + L
Sbjct: 1699 EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1758
Query: 455 AELRETLLRLQLENKRLCRQEAADRERQEELQRHLE-DANRARHGLETQHRL-------- 505
AEL + +++ R E R E+ ++ LE +A R R E RL
Sbjct: 1759 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1818
Query: 506 NQQQLSELRA--QVEDLQKALQEQGG--------KTEDAISILLKRKLEEHLQKLHEADL 555
Q+QL+E A Q + ++ L E+ KTE I++ K E L++L E D
Sbjct: 1819 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE-DE 1877
Query: 556 ELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTME 615
QR+R +EE + R+ +L+ + D++L ER + V+ + +E
Sbjct: 1878 AFQRRR--LEEQAAQHKADIEERLAQLR---KASDSEL----ERQKGLVEDTLRQRRQVE 1928
Query: 616 PKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQRE----QEEKLLISAWYNMG 671
E+ +L+ + LE++ + RS E +E+ + A
Sbjct: 1929 ----------EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ 1978
Query: 672 MALQQRAGEERAPAHAQSFLAQQRLATNSRRGPLGRLASLNLR 714
+A ++ A Q LA + A R+ L + L +
Sbjct: 1979 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2021
Score = 70.9 bits (172), Expect = 4e-12
Identities = 114/468 (24%), Positives = 195/468 (41%), Gaps = 62/468 (13%)
Query: 181 SEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLL 240
+E A + ++++ + Q+ LS+ K + EN L R T + L
Sbjct: 2221 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR--------DKDNTQRFLQE 2272
Query: 241 LQSQLEQLQEENFRLE-SGREDERLRCAELE-----REVAE--LQHRNQALTSLAQEAQA 292
+++Q+ EE RL + +E RLR E R +AE L+ + QA+ QEA
Sbjct: 2273 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAV----QEATR 2328
Query: 293 LKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDEL 352
LK E + L+Q E A + RRL E +E + +QL E G R LE E
Sbjct: 2329 LKAEAELLQQQKELAQEQA-------RRLQEDKE--QMAQQLAEETQGFQ---RTLEAER 2376
Query: 353 RRAGSLRAQLEAQRRQVQEL---QGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLA 409
+R + A+ E + +V E+ Q + +E+A + K E + E T+EK L+
Sbjct: 2377 QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2436
Query: 410 ERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENK 469
+ R+ Q+D + + L E + LL+L+ E
Sbjct: 2437 TLEIQRQ----------------QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2480
Query: 470 RLCRQEAADRERQEELQRHLEDAN---RARHGLETQHRLNQQQLSELRAQVEDLQKALQE 526
+ +QE +E Q Q L + + + +E + +Q + A+ + L++ Q
Sbjct: 2481 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2540
Query: 527 QGGKTEDAISILLKRKLEEHLQKLHEADLELQRKREYIEELEPPT---DSSTARRIEELQ 583
Q + E L+ +EE ++ HEA+ ++RK+E +++LE + A + L+
Sbjct: 2541 QQQQMEQERQRLVA-SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2599
Query: 584 HNLQKKDADLRAM----EERYRRYVDKARMVMQTMEPKQRPAAGAPPE 627
LQ + RA EE V + + + PAA A PE
Sbjct: 2600 EQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2647
Score = 54.3 bits (129), Expect = 4e-07
Identities = 100/471 (21%), Positives = 180/471 (38%), Gaps = 97/471 (20%)
Query: 299 ELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERN-------------------- 338
+L QS E+ Q E+ C+R + EL+++R Q+ E R
Sbjct: 971 QLLQSLEQGAQEESR---CQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRI 1027
Query: 339 --------------------AGHAERTRQLEDELRRAGSLRAQLEAQRRQVQELQG---- 374
+ AE+ L + A +LR++LE ++++++
Sbjct: 1028 AEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1087
Query: 375 ---------------QRQEEAMKA-EKWLFECR-------NLEEKYESVTKEKERLLAER 411
Q EE ++A E+ L E + LE S+ K + + A++
Sbjct: 1088 YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQ 1147
Query: 412 DSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEIL---PAELRETLLRLQLEN 468
+ +ELR AQ L Q D A++L A L +T +R Q E
Sbjct: 1148 PTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVR-QREL 1206
Query: 469 KRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQG 528
++L RQ RE + L L+DA R + ++ + Q + E Q + L + ++ G
Sbjct: 1207 EQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHG 1266
Query: 529 GKTEDAISILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQK 588
K E+ +R ++++ + + +L+L Y +LEP + +++ ++ +
Sbjct: 1267 EKVEEC-----QRFAKQYINAIKDYELQLV---TYKAQLEPVASPAKKPKVQSGSESVIQ 1318
Query: 589 KDADLRA----MEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRH 644
+ DLR + +Y+ ++ ME ++R A Q E R+
Sbjct: 1319 EYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLA----------EQQRAEERERLAE 1368
Query: 645 LEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQR 695
+E EK R E + A LQQR EE + AQQ+
Sbjct: 1369 VEAALEKQRQLAEAHAQAKAQA-EREAKELQQRMQEEVVRREEAAVDAQQQ 1418
Score = 49.3 bits (116), Expect = 1e-05
Identities = 87/378 (23%), Positives = 152/378 (40%), Gaps = 90/378 (23%)
Query: 162 LSPETYG---NFDSQSRRYYFLSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGL 218
L+ ET G +++ +R +S EAE L+ R ++ R E+ Q ++ +
Sbjct: 2361 LAEETQGFQRTLEAERQRQLEMSAEAER---LKLRVAEMSRAQARAEEDAQRFRKQAEEI 2417
Query: 219 RERMGRPEGEGTPGLTAKKLLLLQSQLEQLQEENFRLESGREDERLR--CAELEREVAEL 276
E++ R E T +K+ L+Q+ Q Q+ S + ERLR AELERE +L
Sbjct: 2418 GEKLHRTELA-----TQEKVTLVQTLEIQRQQ------SDHDAERLREAIAELEREKEKL 2466
Query: 277 QHRNQALT------------SLAQEAQALK-----------------------------D 295
Q + L L QE QAL+ D
Sbjct: 2467 QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2526
Query: 296 EMDELRQSSERAGQLEATLTSCRRRL-GELRELRRQVRQLEERNAGHAERTRQLEDELRR 354
E+ + +Q E + + + R+RL + E RR+ + E E R+ ++EL+
Sbjct: 2527 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE-------EGVRRKQEELQ- 2578
Query: 355 AGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSL 414
QLE QRRQ +EL + + + + + LEE++ + E + A + +
Sbjct: 2579 ------QLEQQRRQQEELLAEENQRLRE------QLQLLEEQHRAALAHSEEVTASQVAA 2626
Query: 415 REANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQ 474
+ R A P + + S D L ++ L+E + E +RL +
Sbjct: 2627 TKTLPNGRDALDGPAAEAEPEHSF-------DGLRRKVSAQRLQEAGILSAEELQRLAQG 2679
Query: 475 EAADRE--RQEELQRHLE 490
E R+E+++ +L+
Sbjct: 2680 HTTVDELARREDVRHYLQ 2697
Score = 33.1 bits (74), Expect = 0.92
Identities = 105/481 (21%), Positives = 182/481 (37%), Gaps = 60/481 (12%)
Query: 177 YYFLSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAK 236
Y+ L E E G +L L+ E+QL E + L + L+ G
Sbjct: 365 YHPLDVEKEWG-KLHVAILEREKQLRSEFERLECLQRIVTKLQMEAG------------- 410
Query: 237 KLLLLQSQLEQ----LQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQA 292
L + QL Q LQ + L +G+ +R E+ER+ L + + L + Q
Sbjct: 411 ---LCEEQLNQADALLQSDVRLLAAGKVPQR--AGEVERD---LDKADSMIRLLFNDVQT 462
Query: 293 LKD-EMDELRQSSERAGQLEATLTSCRRR--LGELRELRRQVRQLEERNAGHAERTRQLE 349
LKD + Q R +L L + R L + Q+ + +R +LE
Sbjct: 463 LKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELE 522
Query: 350 DE-LRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLL 408
D LR L A +E + +V + +++A+ L R L + E + ER
Sbjct: 523 DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQ--LGSHRGLHQSIEEFRAKIERAR 580
Query: 409 AERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAA--EILPAELRETLLRLQL 466
++ L A L L A L+ + + +L + + A +E + +
Sbjct: 581 SDEGQLSPATRGAYRDCLGRLDLQYAK-LLNSSKARLRSLESLHSFVAAATKELMWLNEK 639
Query: 467 ENKRLC-------RQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVED 519
E + + A +E L R LE + L+ ++ R VE
Sbjct: 640 EEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVES 699
Query: 520 LQKALQEQGGKTEDAISILLKRKLEEHLQK----------LHEADLELQRKREYIEELEP 569
Q ALQ T+ + + L +E HL++ + EA+ +LQ+ +E +
Sbjct: 700 FQAALQ-----TQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYS 754
Query: 570 PTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQ--RPAAGAPPE 627
S+T R+E+L + Q + L + +A+ V+Q ++P+ P G P
Sbjct: 755 CDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQ-LKPRHPAHPMRGRLPL 813
Query: 628 L 628
L
Sbjct: 814 L 814
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 95.9 bits (237), Expect = 1e-19
Identities = 131/536 (24%), Positives = 229/536 (42%), Gaps = 94/536 (17%)
Query: 233 LTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELE---------------------R 271
LT++ + + L +++EE E R +ER R AE+E R
Sbjct: 1329 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1388
Query: 272 EVAELQHRNQ--------ALTSLAQEAQALKDEMDELRQSSE-----RAGQLEATLTSCR 318
E ELQ R Q A Q+ +++++E+ +LRQSSE +A Q EA S
Sbjct: 1389 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL 1448
Query: 319 RRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRAQLEAQRRQVQE----LQG 374
R E+R +R Q+ E + G E EL+ + + EAQ+RQ QE L+
Sbjct: 1449 RIEEEIRVVRLQLEATERQRGG-------AEGELQALRARAEEAEAQKRQAQEEAERLRR 1501
Query: 375 QRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLR----EANEELRCAQLQPRG 430
Q Q+E+ + + E + + +EK+R L + LR EA LR A+++
Sbjct: 1502 QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1561
Query: 431 LTQ---------ADPSLDPTSTPVDNLAAEILPAELRE---TLLRLQLENKRLCRQEAAD 478
Q A+ L A+ L L+E + +L+ E +R +Q+A
Sbjct: 1562 QVQVALETAQRSAEAELQSKRASFAEKTAQ-LERSLQEEHVAVAQLREEAERRAQQQAEA 1620
Query: 479 RERQEELQRHLE----DANRA-RHGLETQHRLNQQQLSELRA--QVEDLQKALQEQGGKT 531
+EE +R LE AN A R L+ + Q+ L++ A Q E+ ++ + +G
Sbjct: 1621 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1680
Query: 532 EDAI--------SILLKRKL-----------EEHLQKLHEADLELQRKREYIEE----LE 568
E A+ + +R+L E+ L +L + +++R+ +EE L+
Sbjct: 1681 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1740
Query: 569 PPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPEL 628
++T +R +EL+ L K A++ + R +++R + + + AG EL
Sbjct: 1741 REAAAATQKR-QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1799
Query: 629 HSLRTQLRE-RDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERA 683
+LR + R ++ E + QR + E++L +G A + + E A
Sbjct: 1800 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1855
Score = 90.5 bits (223), Expect = 5e-18
Identities = 155/579 (26%), Positives = 245/579 (42%), Gaps = 88/579 (15%)
Query: 182 EEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTA-----K 236
+ AEE + L + LE+Q L Q+ AQ +E R + E A +
Sbjct: 1354 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ 1413
Query: 237 KLLLLQSQLEQL-------------QEENFRLESGREDERLRCAELEREVAELQHRN--- 280
+ +Q +L+QL Q E R +E +R L+ E E Q
Sbjct: 1414 QKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1473
Query: 281 --QALTSLAQEAQALK----DEMDELRQ----SSERAGQLEATLTSCRRRLGE-LRELRR 329
QAL + A+EA+A K +E + LR+ S+R Q E L S + E RE +R
Sbjct: 1474 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1533
Query: 330 QVRQLEERNAGHAERTRQL-EDELRRAGSLRAQLE-AQRRQVQELQGQRQEEAMKAEKWL 387
++ LEE E R+L + E+ RA ++ LE AQR ELQ +R A AEK
Sbjct: 1534 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR---ASFAEKTA 1590
Query: 388 FECRNLEEKYESVTKEKERLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDN 447
R+L+E++ +V + +E AER + ++A E R +A+ L+ +
Sbjct: 1591 QLERSLQEEHVAVAQLREE--AERRAQQQAEAE--------RAREEAERELERWQLKANE 1640
Query: 448 LAAEILPAE---LRETLLRLQLENKRLCRQEAADRE------------RQEEL-QRHLED 491
L AE +++L + + E ++ E A+RE RQ EL ++ LE
Sbjct: 1641 ALRLRLQAEEVAQQKSLAQAEAEKQK----EEAEREARRRGKAEEQAVRQRELAEQELEK 1696
Query: 492 ANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDAISILLKRKLEEHLQKLH 551
+ G Q +Q+L LRA+ E EQ + + L+R+ QK
Sbjct: 1697 QRQLAEGTAQQRLAAEQELIRLRAETEQ-----GEQQRQLLEEELARLQREAAAATQKRQ 1751
Query: 552 EADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVM 611
E + EL + R +E L +S AR EE + +K L A R+R ++A +
Sbjct: 1752 ELEAELAKVRAEMEVLL----ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1807
Query: 612 QTMEPKQRPAAGAPPELHSLRTQ----LRERDVRI---RHLEMDFEKSRSQREQEEKLLI 664
E +R A + R + L E+ I L+ + E + ++E E + L
Sbjct: 1808 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLR 1867
Query: 665 SAWYNMGMALQQRAGEERAPAH---AQSFLAQQRLATNS 700
+ A Q+R EE+A H + LAQ R A++S
Sbjct: 1868 RLAED--EAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1904
Score = 88.6 bits (218), Expect = 2e-17
Identities = 134/541 (24%), Positives = 226/541 (41%), Gaps = 71/541 (13%)
Query: 180 LSEEAEEGDE----LQQRCLDLERQLMLLSEEKQSLAQENAGLRERM---------GRPE 226
L E E+G++ L++ L+R+ ++++Q L E A +R M E
Sbjct: 1718 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1777
Query: 227 GEGTPGLTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAE---LQHRNQAL 283
T + ++L + +L EE RL + E+ A+ +R++AE + R +A
Sbjct: 1778 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE-----AKRQRQLAEEDAARQRAEAE 1832
Query: 284 TSLAQEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHA- 342
LA++ A+ E L+ +E A + + RRL E +R R+LEE+ A H
Sbjct: 1833 RVLAEKLAAI-GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR--RRLEEQAAQHKA 1889
Query: 343 ---ERTRQL----EDELRRAGSLRAQLEAQRRQVQE----LQGQRQEEAMKAEKWLFECR 391
ER QL + EL R L QRRQV+E L+ ++ A + E
Sbjct: 1890 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1949
Query: 392 NLEEKYESVTKEKER--LLAERDSLREANEELRCAQLQPR------GLTQADPSLDPTST 443
+ E + KE+ L A R A EE R + + R +A
Sbjct: 1950 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2009
Query: 444 PVDNLAAEILPAELRETLLRLQLENKRLCR--QEAADRERQEELQRHLEDANRARHGLET 501
V+ L A++ E R R + E+ R + QEAA + Q E + H + L+
Sbjct: 2010 EVERLKAKV--EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2067
Query: 502 QHRLNQQQLSELRAQVEDLQKALQE-QGGKTEDAISILLKRKLEEHLQKLHEADLELQRK 560
+ Q L +LR + E ++A +E + + + R+ E ++L ++ E +
Sbjct: 2068 TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2127
Query: 561 REY----IEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEP 616
R E+L + ARR + Q L++K A A E+++++ + QT+
Sbjct: 2128 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA-ADAEMEKHKKFAE------QTLRQ 2180
Query: 617 KQRPAAGAPPELHSLRTQLRER-------DVRIRHLEMDFEKSRSQREQEEKLLISAWYN 669
K A EL +LR QL E D ++ L+ + ++ QR Q E+ L S
Sbjct: 2181 K----AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2236
Query: 670 M 670
M
Sbjct: 2237 M 2237
Score = 83.6 bits (205), Expect = 6e-16
Identities = 143/554 (25%), Positives = 223/554 (40%), Gaps = 76/554 (13%)
Query: 188 DELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQSQLEQ 247
+EL+ + + ER+L E+ Q +R E + A+K L+
Sbjct: 1539 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE---RS 1595
Query: 248 LQEENFRLESGREDERLRC---AELEREVAELQHRNQALTSLAQEAQALKDEMDELRQ-- 302
LQEE+ + RE+ R AE ER E + + A EA L+ + +E+ Q
Sbjct: 1596 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1655
Query: 303 ---SSERAGQLEATLTSCRRRLGELRELRRQVRQLEERN--------AGHAERTRQLEDE 351
+E Q E RRR G+ E + R+L E+ G A++ E E
Sbjct: 1656 SLAQAEAEKQKEEAEREARRR-GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1714
Query: 352 LRRAGSLRAQLEAQRRQVQELQGQRQEEA----------------MKAEKWLF---ECRN 392
L R + Q E QR+ ++E + Q EA ++AE + + R
Sbjct: 1715 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1774
Query: 393 LEEKYESVTKEKERLLAERDSLREANEE---LRC-AQLQPRGLTQADPSLDPTSTPVDNL 448
EE + K K+RL AE RE EE LR A+ R A+ + +
Sbjct: 1775 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1834
Query: 449 AAEILPAELRETLLRLQLENKRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQ 508
AE L A T RL+ E + +++ A+ ER L+R ED R LE Q ++
Sbjct: 1835 LAEKLAAIGEAT--RLKTEAEIALKEKEAENER---LRRLAEDEAFQRRRLEEQAAQHKA 1889
Query: 509 QLSELRAQVEDLQKA-LQEQGGKTEDAIS---------ILLKRKLEEHLQKLHEADLELQ 558
+ E AQ+ + L+ Q G ED + + LK E+ E +LEL
Sbjct: 1890 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1949
Query: 559 RKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYV-DKARMVMQTMEPK 617
R R E D+ ++ EL+ Q++ L A EER RR ++ + + E
Sbjct: 1950 RIRSNAE------DTLRSKEQAELEAARQRQ---LAAEEERRRREAEERVQKSLAAEEEA 2000
Query: 618 QRPAAGAPPELHSLRT------QLRER--DVRIRHLEMDFEKSRSQREQEEKLLISAWYN 669
R A E+ L+ +LRER R L++ E ++ + + EEK A
Sbjct: 2001 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2060
Query: 670 MGMALQQRAGEERA 683
LQQ +E++
Sbjct: 2061 KEQELQQTLQQEQS 2074
Score = 80.9 bits (198), Expect = 4e-15
Identities = 143/623 (22%), Positives = 255/623 (40%), Gaps = 97/623 (15%)
Query: 133 QRIMTLEESVQHVVMEAIQELM-TKDTPDSLSPETYGNFDSQSRRYYFLSEEAEEGD--- 188
+R+ E++ V + QEL T S+ + G ++ R +EEAEE
Sbjct: 2045 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA----AEEAEEARVQA 2100
Query: 189 -----ELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQS 243
+ +++ + ER E+ Q+ AQ A + E E A++ L Q
Sbjct: 2101 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2160
Query: 244 QL--------EQLQEENFRLESGREDE----RLRCAELEREV----AELQHRNQALTSLA 287
Q ++ E+ R ++ E E RL+ E + + ELQ T A
Sbjct: 2161 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAA 2220
Query: 288 QEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQ 347
++ +++E+ +R E +L+A + + R L LR+ R L+E AE+ +Q
Sbjct: 2221 RQRSQVEEELFSVRVQMEELSKLKARIEAENRAL-ILRDKDNTQRFLQEE----AEKMKQ 2275
Query: 348 LEDELRRAGSLRAQLEAQRRQVQE------------LQGQRQEEAMKAEKWLFECRNLEE 395
+ +E R S+ AQ A+ RQ+ E + ++ + +A + E L++
Sbjct: 2276 VAEEAARL-SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2334
Query: 396 KYESVTKEKERLLAERDSL-REANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILP 454
+ E ++ RL +++ + ++ EE + Q Q + + + AE+
Sbjct: 2335 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2394
Query: 455 AELRET----LLRLQLEN--KRLCRQEAADRERQE-----ELQRHLED--ANRARHG--- 498
A+ R R Q E ++L R E A +E+ E+QR D A R R
Sbjct: 2395 AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2454
Query: 499 LETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDAISILLKRKLEEHLQKLHEADLELQ 558
LE + QQ+ L+ + E++Q QEQ LL+ L E D LQ
Sbjct: 2455 LEREKEKLQQEAKLLQLKSEEMQTVQQEQ----------LLQETQALQQSFLSEKDSLLQ 2504
Query: 559 RKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQ 618
R+R +IE+ ++E+L + K LR ++R ++ +++ R Q
Sbjct: 2505 RER-FIEQ--------EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQER---------Q 2546
Query: 619 RPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRA 678
R A + R + E + +R + + ++ QR Q+E+LL + LQ
Sbjct: 2547 RLVA----SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2602
Query: 679 GEERAP-AHAQSFLAQQRLATNS 700
+ RA AH++ A Q AT +
Sbjct: 2603 EQHRAALAHSEEVTASQVAATKT 2625
Score = 80.1 bits (196), Expect = 7e-15
Identities = 115/545 (21%), Positives = 226/545 (41%), Gaps = 44/545 (8%)
Query: 183 EAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQ 242
+ E E QR + ++ + + +A+ +A + + PE +L L
Sbjct: 1012 DKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTL 1071
Query: 243 SQLEQLQEENFRLESGREDERLRCAELE-REVAELQHRNQALTSLAQEAQALKDEMDELR 301
+LEQ+ R S E+L+ L R + +A +EAQA+ + EL
Sbjct: 1072 GKLEQV-----RSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELE 1126
Query: 302 QSSERAGQLEATLTSCRRRLGELRELRRQVRQLEER-NAGHAERTRQLE-------DELR 353
+ +L A + + LR+ R +++ ER H ER ++E L
Sbjct: 1127 ATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLE 1186
Query: 354 RAGSLRAQLEAQRRQVQELQGQ---RQEEAMKAEKWLFECRNLEEKYESV-----TKEKE 405
R ++ AQ + ++R++++L Q +E A WL + R +E+ +++ +E
Sbjct: 1187 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1246
Query: 406 RLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQ 465
+L E+ L E + R Q ++ + A++ P ++Q
Sbjct: 1247 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQ 1306
Query: 466 LENKRLCRQEAADRERQEEL----QRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQ 521
++ + ++ R EL ++++ + +E + RL +QQ +E R ++ +++
Sbjct: 1307 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1366
Query: 522 KALQEQGGKTE---------DAISILLKRKLEEHLQKLHEADLEL-QRKREYIEELEPPT 571
AL++Q E + + L+++++E + + EA ++ Q+KR EEL+
Sbjct: 1367 AALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR 1426
Query: 572 DSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSL 631
SS A +Q K A E R ++ R+V +E +R GA EL +L
Sbjct: 1427 QSSEA--------EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1478
Query: 632 RTQLRERDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFL 691
R + E + + R + + E+ R Q + E + A + ++ A R A L
Sbjct: 1479 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL 1538
Query: 692 AQQRL 696
+ RL
Sbjct: 1539 EELRL 1543
Score = 79.0 bits (193), Expect = 1e-14
Identities = 144/643 (22%), Positives = 255/643 (39%), Gaps = 85/643 (13%)
Query: 126 EKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYFLSEEAE 185
E D Q+ +++E +Q + + E+ K + + + + R E E
Sbjct: 1406 EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE 1465
Query: 186 ------EGD--ELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKK 237
EG+ L+ R + E Q EE + L ++ +R + E E + A+
Sbjct: 1466 RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEA 1525
Query: 238 LLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEM 297
+ Q E RL++ + RLR AE+ER Q +L ++ + E+
Sbjct: 1526 EAAREKQRALQALEELRLQAEEAERRLRQAEVER-------ARQVQVALETAQRSAEAEL 1578
Query: 298 DELRQS-SERAGQLEATLTSCRRRLGELR-ELRRQVRQLEERNAGHAERTRQLED-ELRR 354
R S +E+ QLE +L + +LR E R+ +Q E E R+LE +L+
Sbjct: 1579 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1638
Query: 355 AGSLRAQLE----AQRRQVQELQGQRQEEAM--------KAEKWLFECRNLEEKYESVTK 402
+LR +L+ AQ++ + + + ++Q+E KAE+ R L E+
Sbjct: 1639 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ----EL 1694
Query: 403 EKERLLAERDSLREANEELRCAQL--------QPRGLTQADPSLDPTSTPVDNLAAEILP 454
EK+R LAE + + E +L Q R L + + + + L
Sbjct: 1695 EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1754
Query: 455 AELRETLLRLQLENKRLCRQEAADRERQEELQRHLE-DANRARHGLETQHRL-------- 505
AEL + +++ R E R E+ ++ LE +A R R E RL
Sbjct: 1755 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1814
Query: 506 NQQQLSELRA--QVEDLQKALQEQGG--------KTEDAISILLKRKLEEHLQKLHEADL 555
Q+QL+E A Q + ++ L E+ KTE I++ K E L++L E D
Sbjct: 1815 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE-DE 1873
Query: 556 ELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTME 615
QR+R +EE + R+ +L+ + D++L ER + V+ + +E
Sbjct: 1874 AFQRRR--LEEQAAQHKADIEERLAQLR---KASDSEL----ERQKGLVEDTLRQRRQVE 1924
Query: 616 PKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQRE----QEEKLLISAWYNMG 671
E+ +L+ + LE++ + RS E +E+ + A
Sbjct: 1925 ----------EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ 1974
Query: 672 MALQQRAGEERAPAHAQSFLAQQRLATNSRRGPLGRLASLNLR 714
+A ++ A Q LA + A R+ L + L +
Sbjct: 1975 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2017
Score = 70.9 bits (172), Expect = 4e-12
Identities = 114/468 (24%), Positives = 195/468 (41%), Gaps = 62/468 (13%)
Query: 181 SEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLL 240
+E A + ++++ + Q+ LS+ K + EN L R T + L
Sbjct: 2217 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR--------DKDNTQRFLQE 2268
Query: 241 LQSQLEQLQEENFRLE-SGREDERLRCAELE-----REVAE--LQHRNQALTSLAQEAQA 292
+++Q+ EE RL + +E RLR E R +AE L+ + QA+ QEA
Sbjct: 2269 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAV----QEATR 2324
Query: 293 LKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDEL 352
LK E + L+Q E A + RRL E +E + +QL E G R LE E
Sbjct: 2325 LKAEAELLQQQKELAQEQA-------RRLQEDKE--QMAQQLAEETQGFQ---RTLEAER 2372
Query: 353 RRAGSLRAQLEAQRRQVQEL---QGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLA 409
+R + A+ E + +V E+ Q + +E+A + K E + E T+EK L+
Sbjct: 2373 QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2432
Query: 410 ERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENK 469
+ R+ Q+D + + L E + LL+L+ E
Sbjct: 2433 TLEIQRQ----------------QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2476
Query: 470 RLCRQEAADRERQEELQRHLEDAN---RARHGLETQHRLNQQQLSELRAQVEDLQKALQE 526
+ +QE +E Q Q L + + + +E + +Q + A+ + L++ Q
Sbjct: 2477 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2536
Query: 527 QGGKTEDAISILLKRKLEEHLQKLHEADLELQRKREYIEELEPPT---DSSTARRIEELQ 583
Q + E L+ +EE ++ HEA+ ++RK+E +++LE + A + L+
Sbjct: 2537 QQQQMEQERQRLVA-SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2595
Query: 584 HNLQKKDADLRAM----EERYRRYVDKARMVMQTMEPKQRPAAGAPPE 627
LQ + RA EE V + + + PAA A PE
Sbjct: 2596 EQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2643
Score = 54.3 bits (129), Expect = 4e-07
Identities = 100/471 (21%), Positives = 180/471 (38%), Gaps = 97/471 (20%)
Query: 299 ELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERN-------------------- 338
+L QS E+ Q E+ C+R + EL+++R Q+ E R
Sbjct: 967 QLLQSLEQGAQEESR---CQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRI 1023
Query: 339 --------------------AGHAERTRQLEDELRRAGSLRAQLEAQRRQVQELQG---- 374
+ AE+ L + A +LR++LE ++++++
Sbjct: 1024 AEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1083
Query: 375 ---------------QRQEEAMKA-EKWLFECR-------NLEEKYESVTKEKERLLAER 411
Q EE ++A E+ L E + LE S+ K + + A++
Sbjct: 1084 YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQ 1143
Query: 412 DSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEIL---PAELRETLLRLQLEN 468
+ +ELR AQ L Q D A++L A L +T +R Q E
Sbjct: 1144 PTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVR-QREL 1202
Query: 469 KRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQG 528
++L RQ RE + L L+DA R + ++ + Q + E Q + L + ++ G
Sbjct: 1203 EQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHG 1262
Query: 529 GKTEDAISILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQK 588
K E+ +R ++++ + + +L+L Y +LEP + +++ ++ +
Sbjct: 1263 EKVEEC-----QRFAKQYINAIKDYELQLV---TYKAQLEPVASPAKKPKVQSGSESVIQ 1314
Query: 589 KDADLRA----MEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRH 644
+ DLR + +Y+ ++ ME ++R A Q E R+
Sbjct: 1315 EYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLA----------EQQRAEERERLAE 1364
Query: 645 LEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQR 695
+E EK R E + A LQQR EE + AQQ+
Sbjct: 1365 VEAALEKQRQLAEAHAQAKAQA-EREAKELQQRMQEEVVRREEAAVDAQQQ 1414
Score = 49.3 bits (116), Expect = 1e-05
Identities = 87/378 (23%), Positives = 152/378 (40%), Gaps = 90/378 (23%)
Query: 162 LSPETYG---NFDSQSRRYYFLSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGL 218
L+ ET G +++ +R +S EAE L+ R ++ R E+ Q ++ +
Sbjct: 2357 LAEETQGFQRTLEAERQRQLEMSAEAER---LKLRVAEMSRAQARAEEDAQRFRKQAEEI 2413
Query: 219 RERMGRPEGEGTPGLTAKKLLLLQSQLEQLQEENFRLESGREDERLR--CAELEREVAEL 276
E++ R E T +K+ L+Q+ Q Q+ S + ERLR AELERE +L
Sbjct: 2414 GEKLHRTELA-----TQEKVTLVQTLEIQRQQ------SDHDAERLREAIAELEREKEKL 2462
Query: 277 QHRNQALT------------SLAQEAQALK-----------------------------D 295
Q + L L QE QAL+ D
Sbjct: 2463 QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2522
Query: 296 EMDELRQSSERAGQLEATLTSCRRRL-GELRELRRQVRQLEERNAGHAERTRQLEDELRR 354
E+ + +Q E + + + R+RL + E RR+ + E E R+ ++EL+
Sbjct: 2523 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE-------EGVRRKQEELQ- 2574
Query: 355 AGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSL 414
QLE QRRQ +EL + + + + + LEE++ + E + A + +
Sbjct: 2575 ------QLEQQRRQQEELLAEENQRLRE------QLQLLEEQHRAALAHSEEVTASQVAA 2622
Query: 415 REANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQ 474
+ R A P + + S D L ++ L+E + E +RL +
Sbjct: 2623 TKTLPNGRDALDGPAAEAEPEHSF-------DGLRRKVSAQRLQEAGILSAEELQRLAQG 2675
Query: 475 EAADRE--RQEELQRHLE 490
E R+E+++ +L+
Sbjct: 2676 HTTVDELARREDVRHYLQ 2693
Score = 33.1 bits (74), Expect = 0.92
Identities = 105/481 (21%), Positives = 182/481 (37%), Gaps = 60/481 (12%)
Query: 177 YYFLSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAK 236
Y+ L E E G +L L+ E+QL E + L + L+ G
Sbjct: 361 YHPLDVEKEWG-KLHVAILEREKQLRSEFERLECLQRIVTKLQMEAG------------- 406
Query: 237 KLLLLQSQLEQ----LQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQA 292
L + QL Q LQ + L +G+ +R E+ER+ L + + L + Q
Sbjct: 407 ---LCEEQLNQADALLQSDVRLLAAGKVPQR--AGEVERD---LDKADSMIRLLFNDVQT 458
Query: 293 LKD-EMDELRQSSERAGQLEATLTSCRRR--LGELRELRRQVRQLEERNAGHAERTRQLE 349
LKD + Q R +L L + R L + Q+ + +R +LE
Sbjct: 459 LKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELE 518
Query: 350 DE-LRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLL 408
D LR L A +E + +V + +++A+ L R L + E + ER
Sbjct: 519 DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQ--LGSHRGLHQSIEEFRAKIERAR 576
Query: 409 AERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAA--EILPAELRETLLRLQL 466
++ L A L L A L+ + + +L + + A +E + +
Sbjct: 577 SDEGQLSPATRGAYRDCLGRLDLQYAK-LLNSSKARLRSLESLHSFVAAATKELMWLNEK 635
Query: 467 ENKRLC-------RQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVED 519
E + + A +E L R LE + L+ ++ R VE
Sbjct: 636 EEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVES 695
Query: 520 LQKALQEQGGKTEDAISILLKRKLEEHLQK----------LHEADLELQRKREYIEELEP 569
Q ALQ T+ + + L +E HL++ + EA+ +LQ+ +E +
Sbjct: 696 FQAALQ-----TQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYS 750
Query: 570 PTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQ--RPAAGAPPE 627
S+T R+E+L + Q + L + +A+ V+Q ++P+ P G P
Sbjct: 751 CDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQ-LKPRHPAHPMRGRLPL 809
Query: 628 L 628
L
Sbjct: 810 L 810
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 95.9 bits (237), Expect = 1e-19
Identities = 131/536 (24%), Positives = 229/536 (42%), Gaps = 94/536 (17%)
Query: 233 LTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELE---------------------R 271
LT++ + + L +++EE E R +ER R AE+E R
Sbjct: 1297 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1356
Query: 272 EVAELQHRNQ--------ALTSLAQEAQALKDEMDELRQSSE-----RAGQLEATLTSCR 318
E ELQ R Q A Q+ +++++E+ +LRQSSE +A Q EA S
Sbjct: 1357 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL 1416
Query: 319 RRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRAQLEAQRRQVQE----LQG 374
R E+R +R Q+ E + G E EL+ + + EAQ+RQ QE L+
Sbjct: 1417 RIEEEIRVVRLQLEATERQRGG-------AEGELQALRARAEEAEAQKRQAQEEAERLRR 1469
Query: 375 QRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLR----EANEELRCAQLQPRG 430
Q Q+E+ + + E + + +EK+R L + LR EA LR A+++
Sbjct: 1470 QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1529
Query: 431 LTQ---------ADPSLDPTSTPVDNLAAEILPAELRE---TLLRLQLENKRLCRQEAAD 478
Q A+ L A+ L L+E + +L+ E +R +Q+A
Sbjct: 1530 QVQVALETAQRSAEAELQSKRASFAEKTAQ-LERSLQEEHVAVAQLREEAERRAQQQAEA 1588
Query: 479 RERQEELQRHLE----DANRA-RHGLETQHRLNQQQLSELRA--QVEDLQKALQEQGGKT 531
+EE +R LE AN A R L+ + Q+ L++ A Q E+ ++ + +G
Sbjct: 1589 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1648
Query: 532 EDAI--------SILLKRKL-----------EEHLQKLHEADLELQRKREYIEE----LE 568
E A+ + +R+L E+ L +L + +++R+ +EE L+
Sbjct: 1649 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1708
Query: 569 PPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPEL 628
++T +R +EL+ L K A++ + R +++R + + + AG EL
Sbjct: 1709 REAAAATQKR-QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1767
Query: 629 HSLRTQLRE-RDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERA 683
+LR + R ++ E + QR + E++L +G A + + E A
Sbjct: 1768 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1823
Score = 90.5 bits (223), Expect = 5e-18
Identities = 155/579 (26%), Positives = 245/579 (42%), Gaps = 88/579 (15%)
Query: 182 EEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTA-----K 236
+ AEE + L + LE+Q L Q+ AQ +E R + E A +
Sbjct: 1322 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ 1381
Query: 237 KLLLLQSQLEQL-------------QEENFRLESGREDERLRCAELEREVAELQHRN--- 280
+ +Q +L+QL Q E R +E +R L+ E E Q
Sbjct: 1382 QKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1441
Query: 281 --QALTSLAQEAQALK----DEMDELRQ----SSERAGQLEATLTSCRRRLGE-LRELRR 329
QAL + A+EA+A K +E + LR+ S+R Q E L S + E RE +R
Sbjct: 1442 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1501
Query: 330 QVRQLEERNAGHAERTRQL-EDELRRAGSLRAQLE-AQRRQVQELQGQRQEEAMKAEKWL 387
++ LEE E R+L + E+ RA ++ LE AQR ELQ +R A AEK
Sbjct: 1502 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR---ASFAEKTA 1558
Query: 388 FECRNLEEKYESVTKEKERLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDN 447
R+L+E++ +V + +E AER + ++A E R +A+ L+ +
Sbjct: 1559 QLERSLQEEHVAVAQLREE--AERRAQQQAEAE--------RAREEAERELERWQLKANE 1608
Query: 448 LAAEILPAE---LRETLLRLQLENKRLCRQEAADRE------------RQEEL-QRHLED 491
L AE +++L + + E ++ E A+RE RQ EL ++ LE
Sbjct: 1609 ALRLRLQAEEVAQQKSLAQAEAEKQK----EEAEREARRRGKAEEQAVRQRELAEQELEK 1664
Query: 492 ANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDAISILLKRKLEEHLQKLH 551
+ G Q +Q+L LRA+ E EQ + + L+R+ QK
Sbjct: 1665 QRQLAEGTAQQRLAAEQELIRLRAETEQ-----GEQQRQLLEEELARLQREAAAATQKRQ 1719
Query: 552 EADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVM 611
E + EL + R +E L +S AR EE + +K L A R+R ++A +
Sbjct: 1720 ELEAELAKVRAEMEVLL----ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1775
Query: 612 QTMEPKQRPAAGAPPELHSLRTQ----LRERDVRI---RHLEMDFEKSRSQREQEEKLLI 664
E +R A + R + L E+ I L+ + E + ++E E + L
Sbjct: 1776 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLR 1835
Query: 665 SAWYNMGMALQQRAGEERAPAH---AQSFLAQQRLATNS 700
+ A Q+R EE+A H + LAQ R A++S
Sbjct: 1836 RLAED--EAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1872
Score = 88.6 bits (218), Expect = 2e-17
Identities = 134/541 (24%), Positives = 226/541 (41%), Gaps = 71/541 (13%)
Query: 180 LSEEAEEGDE----LQQRCLDLERQLMLLSEEKQSLAQENAGLRERM---------GRPE 226
L E E+G++ L++ L+R+ ++++Q L E A +R M E
Sbjct: 1686 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1745
Query: 227 GEGTPGLTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAE---LQHRNQAL 283
T + ++L + +L EE RL + E+ A+ +R++AE + R +A
Sbjct: 1746 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE-----AKRQRQLAEEDAARQRAEAE 1800
Query: 284 TSLAQEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHA- 342
LA++ A+ E L+ +E A + + RRL E +R R+LEE+ A H
Sbjct: 1801 RVLAEKLAAI-GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR--RRLEEQAAQHKA 1857
Query: 343 ---ERTRQL----EDELRRAGSLRAQLEAQRRQVQE----LQGQRQEEAMKAEKWLFECR 391
ER QL + EL R L QRRQV+E L+ ++ A + E
Sbjct: 1858 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1917
Query: 392 NLEEKYESVTKEKER--LLAERDSLREANEELRCAQLQPR------GLTQADPSLDPTST 443
+ E + KE+ L A R A EE R + + R +A
Sbjct: 1918 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 1977
Query: 444 PVDNLAAEILPAELRETLLRLQLENKRLCR--QEAADRERQEELQRHLEDANRARHGLET 501
V+ L A++ E R R + E+ R + QEAA + Q E + H + L+
Sbjct: 1978 EVERLKAKV--EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2035
Query: 502 QHRLNQQQLSELRAQVEDLQKALQE-QGGKTEDAISILLKRKLEEHLQKLHEADLELQRK 560
+ Q L +LR + E ++A +E + + + R+ E ++L ++ E +
Sbjct: 2036 TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2095
Query: 561 REY----IEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEP 616
R E+L + ARR + Q L++K A A E+++++ + QT+
Sbjct: 2096 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA-ADAEMEKHKKFAE------QTLRQ 2148
Query: 617 KQRPAAGAPPELHSLRTQLRER-------DVRIRHLEMDFEKSRSQREQEEKLLISAWYN 669
K A EL +LR QL E D ++ L+ + ++ QR Q E+ L S
Sbjct: 2149 K----AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2204
Query: 670 M 670
M
Sbjct: 2205 M 2205
Score = 83.6 bits (205), Expect = 6e-16
Identities = 143/554 (25%), Positives = 223/554 (40%), Gaps = 76/554 (13%)
Query: 188 DELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQSQLEQ 247
+EL+ + + ER+L E+ Q +R E + A+K L+
Sbjct: 1507 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE---RS 1563
Query: 248 LQEENFRLESGREDERLRC---AELEREVAELQHRNQALTSLAQEAQALKDEMDELRQ-- 302
LQEE+ + RE+ R AE ER E + + A EA L+ + +E+ Q
Sbjct: 1564 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1623
Query: 303 ---SSERAGQLEATLTSCRRRLGELRELRRQVRQLEERN--------AGHAERTRQLEDE 351
+E Q E RRR G+ E + R+L E+ G A++ E E
Sbjct: 1624 SLAQAEAEKQKEEAEREARRR-GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1682
Query: 352 LRRAGSLRAQLEAQRRQVQELQGQRQEEA----------------MKAEKWLF---ECRN 392
L R + Q E QR+ ++E + Q EA ++AE + + R
Sbjct: 1683 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1742
Query: 393 LEEKYESVTKEKERLLAERDSLREANEE---LRC-AQLQPRGLTQADPSLDPTSTPVDNL 448
EE + K K+RL AE RE EE LR A+ R A+ + +
Sbjct: 1743 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1802
Query: 449 AAEILPAELRETLLRLQLENKRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQ 508
AE L A T RL+ E + +++ A+ ER L+R ED R LE Q ++
Sbjct: 1803 LAEKLAAIGEAT--RLKTEAEIALKEKEAENER---LRRLAEDEAFQRRRLEEQAAQHKA 1857
Query: 509 QLSELRAQVEDLQKA-LQEQGGKTEDAIS---------ILLKRKLEEHLQKLHEADLELQ 558
+ E AQ+ + L+ Q G ED + + LK E+ E +LEL
Sbjct: 1858 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1917
Query: 559 RKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYV-DKARMVMQTMEPK 617
R R E D+ ++ EL+ Q++ L A EER RR ++ + + E
Sbjct: 1918 RIRSNAE------DTLRSKEQAELEAARQRQ---LAAEEERRRREAEERVQKSLAAEEEA 1968
Query: 618 QRPAAGAPPELHSLRT------QLRER--DVRIRHLEMDFEKSRSQREQEEKLLISAWYN 669
R A E+ L+ +LRER R L++ E ++ + + EEK A
Sbjct: 1969 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2028
Query: 670 MGMALQQRAGEERA 683
LQQ +E++
Sbjct: 2029 KEQELQQTLQQEQS 2042
Score = 80.9 bits (198), Expect = 4e-15
Identities = 143/623 (22%), Positives = 255/623 (40%), Gaps = 97/623 (15%)
Query: 133 QRIMTLEESVQHVVMEAIQELM-TKDTPDSLSPETYGNFDSQSRRYYFLSEEAEEGD--- 188
+R+ E++ V + QEL T S+ + G ++ R +EEAEE
Sbjct: 2013 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA----AEEAEEARVQA 2068
Query: 189 -----ELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQS 243
+ +++ + ER E+ Q+ AQ A + E E A++ L Q
Sbjct: 2069 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2128
Query: 244 QL--------EQLQEENFRLESGREDE----RLRCAELEREV----AELQHRNQALTSLA 287
Q ++ E+ R ++ E E RL+ E + + ELQ T A
Sbjct: 2129 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAA 2188
Query: 288 QEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQ 347
++ +++E+ +R E +L+A + + R L LR+ R L+E AE+ +Q
Sbjct: 2189 RQRSQVEEELFSVRVQMEELSKLKARIEAENRAL-ILRDKDNTQRFLQEE----AEKMKQ 2243
Query: 348 LEDELRRAGSLRAQLEAQRRQVQE------------LQGQRQEEAMKAEKWLFECRNLEE 395
+ +E R S+ AQ A+ RQ+ E + ++ + +A + E L++
Sbjct: 2244 VAEEAARL-SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2302
Query: 396 KYESVTKEKERLLAERDSL-REANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILP 454
+ E ++ RL +++ + ++ EE + Q Q + + + AE+
Sbjct: 2303 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2362
Query: 455 AELRET----LLRLQLEN--KRLCRQEAADRERQE-----ELQRHLED--ANRARHG--- 498
A+ R R Q E ++L R E A +E+ E+QR D A R R
Sbjct: 2363 AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2422
Query: 499 LETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDAISILLKRKLEEHLQKLHEADLELQ 558
LE + QQ+ L+ + E++Q QEQ LL+ L E D LQ
Sbjct: 2423 LEREKEKLQQEAKLLQLKSEEMQTVQQEQ----------LLQETQALQQSFLSEKDSLLQ 2472
Query: 559 RKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQ 618
R+R +IE+ ++E+L + K LR ++R ++ +++ R Q
Sbjct: 2473 RER-FIEQ--------EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQER---------Q 2514
Query: 619 RPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRA 678
R A + R + E + +R + + ++ QR Q+E+LL + LQ
Sbjct: 2515 RLVA----SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2570
Query: 679 GEERAP-AHAQSFLAQQRLATNS 700
+ RA AH++ A Q AT +
Sbjct: 2571 EQHRAALAHSEEVTASQVAATKT 2593
Score = 80.1 bits (196), Expect = 7e-15
Identities = 115/545 (21%), Positives = 226/545 (41%), Gaps = 44/545 (8%)
Query: 183 EAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQ 242
+ E E QR + ++ + + +A+ +A + + PE +L L
Sbjct: 980 DKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTL 1039
Query: 243 SQLEQLQEENFRLESGREDERLRCAELE-REVAELQHRNQALTSLAQEAQALKDEMDELR 301
+LEQ+ R S E+L+ L R + +A +EAQA+ + EL
Sbjct: 1040 GKLEQV-----RSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELE 1094
Query: 302 QSSERAGQLEATLTSCRRRLGELRELRRQVRQLEER-NAGHAERTRQLE-------DELR 353
+ +L A + + LR+ R +++ ER H ER ++E L
Sbjct: 1095 ATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLE 1154
Query: 354 RAGSLRAQLEAQRRQVQELQGQ---RQEEAMKAEKWLFECRNLEEKYESV-----TKEKE 405
R ++ AQ + ++R++++L Q +E A WL + R +E+ +++ +E
Sbjct: 1155 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1214
Query: 406 RLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQ 465
+L E+ L E + R Q ++ + A++ P ++Q
Sbjct: 1215 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQ 1274
Query: 466 LENKRLCRQEAADRERQEEL----QRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQ 521
++ + ++ R EL ++++ + +E + RL +QQ +E R ++ +++
Sbjct: 1275 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1334
Query: 522 KALQEQGGKTE---------DAISILLKRKLEEHLQKLHEADLEL-QRKREYIEELEPPT 571
AL++Q E + + L+++++E + + EA ++ Q+KR EEL+
Sbjct: 1335 AALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR 1394
Query: 572 DSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSL 631
SS A +Q K A E R ++ R+V +E +R GA EL +L
Sbjct: 1395 QSSEA--------EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1446
Query: 632 RTQLRERDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFL 691
R + E + + R + + E+ R Q + E + A + ++ A R A L
Sbjct: 1447 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL 1506
Query: 692 AQQRL 696
+ RL
Sbjct: 1507 EELRL 1511
Score = 79.0 bits (193), Expect = 1e-14
Identities = 144/643 (22%), Positives = 255/643 (39%), Gaps = 85/643 (13%)
Query: 126 EKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYFLSEEAE 185
E D Q+ +++E +Q + + E+ K + + + + R E E
Sbjct: 1374 EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE 1433
Query: 186 ------EGD--ELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKK 237
EG+ L+ R + E Q EE + L ++ +R + E E + A+
Sbjct: 1434 RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEA 1493
Query: 238 LLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEM 297
+ Q E RL++ + RLR AE+ER Q +L ++ + E+
Sbjct: 1494 EAAREKQRALQALEELRLQAEEAERRLRQAEVER-------ARQVQVALETAQRSAEAEL 1546
Query: 298 DELRQS-SERAGQLEATLTSCRRRLGELR-ELRRQVRQLEERNAGHAERTRQLED-ELRR 354
R S +E+ QLE +L + +LR E R+ +Q E E R+LE +L+
Sbjct: 1547 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1606
Query: 355 AGSLRAQLE----AQRRQVQELQGQRQEEAM--------KAEKWLFECRNLEEKYESVTK 402
+LR +L+ AQ++ + + + ++Q+E KAE+ R L E+
Sbjct: 1607 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ----EL 1662
Query: 403 EKERLLAERDSLREANEELRCAQL--------QPRGLTQADPSLDPTSTPVDNLAAEILP 454
EK+R LAE + + E +L Q R L + + + + L
Sbjct: 1663 EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1722
Query: 455 AELRETLLRLQLENKRLCRQEAADRERQEELQRHLE-DANRARHGLETQHRL-------- 505
AEL + +++ R E R E+ ++ LE +A R R E RL
Sbjct: 1723 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1782
Query: 506 NQQQLSELRA--QVEDLQKALQEQGG--------KTEDAISILLKRKLEEHLQKLHEADL 555
Q+QL+E A Q + ++ L E+ KTE I++ K E L++L E D
Sbjct: 1783 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE-DE 1841
Query: 556 ELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTME 615
QR+R +EE + R+ +L+ + D++L ER + V+ + +E
Sbjct: 1842 AFQRRR--LEEQAAQHKADIEERLAQLR---KASDSEL----ERQKGLVEDTLRQRRQVE 1892
Query: 616 PKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQRE----QEEKLLISAWYNMG 671
E+ +L+ + LE++ + RS E +E+ + A
Sbjct: 1893 ----------EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ 1942
Query: 672 MALQQRAGEERAPAHAQSFLAQQRLATNSRRGPLGRLASLNLR 714
+A ++ A Q LA + A R+ L + L +
Sbjct: 1943 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 1985
Score = 70.9 bits (172), Expect = 4e-12
Identities = 114/468 (24%), Positives = 195/468 (41%), Gaps = 62/468 (13%)
Query: 181 SEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLL 240
+E A + ++++ + Q+ LS+ K + EN L R T + L
Sbjct: 2185 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR--------DKDNTQRFLQE 2236
Query: 241 LQSQLEQLQEENFRLE-SGREDERLRCAELE-----REVAE--LQHRNQALTSLAQEAQA 292
+++Q+ EE RL + +E RLR E R +AE L+ + QA+ QEA
Sbjct: 2237 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAV----QEATR 2292
Query: 293 LKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDEL 352
LK E + L+Q E A + RRL E +E + +QL E G R LE E
Sbjct: 2293 LKAEAELLQQQKELAQEQA-------RRLQEDKE--QMAQQLAEETQGFQ---RTLEAER 2340
Query: 353 RRAGSLRAQLEAQRRQVQEL---QGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLA 409
+R + A+ E + +V E+ Q + +E+A + K E + E T+EK L+
Sbjct: 2341 QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2400
Query: 410 ERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENK 469
+ R+ Q+D + + L E + LL+L+ E
Sbjct: 2401 TLEIQRQ----------------QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2444
Query: 470 RLCRQEAADRERQEELQRHLEDAN---RARHGLETQHRLNQQQLSELRAQVEDLQKALQE 526
+ +QE +E Q Q L + + + +E + +Q + A+ + L++ Q
Sbjct: 2445 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2504
Query: 527 QGGKTEDAISILLKRKLEEHLQKLHEADLELQRKREYIEELEPPT---DSSTARRIEELQ 583
Q + E L+ +EE ++ HEA+ ++RK+E +++LE + A + L+
Sbjct: 2505 QQQQMEQERQRLVA-SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2563
Query: 584 HNLQKKDADLRAM----EERYRRYVDKARMVMQTMEPKQRPAAGAPPE 627
LQ + RA EE V + + + PAA A PE
Sbjct: 2564 EQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2611
Score = 54.3 bits (129), Expect = 4e-07
Identities = 100/471 (21%), Positives = 180/471 (38%), Gaps = 97/471 (20%)
Query: 299 ELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERN-------------------- 338
+L QS E+ Q E+ C+R + EL+++R Q+ E R
Sbjct: 935 QLLQSLEQGAQEESR---CQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRI 991
Query: 339 --------------------AGHAERTRQLEDELRRAGSLRAQLEAQRRQVQELQG---- 374
+ AE+ L + A +LR++LE ++++++
Sbjct: 992 AEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1051
Query: 375 ---------------QRQEEAMKA-EKWLFECR-------NLEEKYESVTKEKERLLAER 411
Q EE ++A E+ L E + LE S+ K + + A++
Sbjct: 1052 YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQ 1111
Query: 412 DSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEIL---PAELRETLLRLQLEN 468
+ +ELR AQ L Q D A++L A L +T +R Q E
Sbjct: 1112 PTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVR-QREL 1170
Query: 469 KRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQG 528
++L RQ RE + L L+DA R + ++ + Q + E Q + L + ++ G
Sbjct: 1171 EQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHG 1230
Query: 529 GKTEDAISILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQK 588
K E+ +R ++++ + + +L+L Y +LEP + +++ ++ +
Sbjct: 1231 EKVEEC-----QRFAKQYINAIKDYELQLV---TYKAQLEPVASPAKKPKVQSGSESVIQ 1282
Query: 589 KDADLRA----MEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRH 644
+ DLR + +Y+ ++ ME ++R A Q E R+
Sbjct: 1283 EYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLA----------EQQRAEERERLAE 1332
Query: 645 LEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQR 695
+E EK R E + A LQQR EE + AQQ+
Sbjct: 1333 VEAALEKQRQLAEAHAQAKAQA-EREAKELQQRMQEEVVRREEAAVDAQQQ 1382
Score = 49.3 bits (116), Expect = 1e-05
Identities = 87/378 (23%), Positives = 152/378 (40%), Gaps = 90/378 (23%)
Query: 162 LSPETYG---NFDSQSRRYYFLSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGL 218
L+ ET G +++ +R +S EAE L+ R ++ R E+ Q ++ +
Sbjct: 2325 LAEETQGFQRTLEAERQRQLEMSAEAER---LKLRVAEMSRAQARAEEDAQRFRKQAEEI 2381
Query: 219 RERMGRPEGEGTPGLTAKKLLLLQSQLEQLQEENFRLESGREDERLR--CAELEREVAEL 276
E++ R E T +K+ L+Q+ Q Q+ S + ERLR AELERE +L
Sbjct: 2382 GEKLHRTELA-----TQEKVTLVQTLEIQRQQ------SDHDAERLREAIAELEREKEKL 2430
Query: 277 QHRNQALT------------SLAQEAQALK-----------------------------D 295
Q + L L QE QAL+ D
Sbjct: 2431 QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2490
Query: 296 EMDELRQSSERAGQLEATLTSCRRRL-GELRELRRQVRQLEERNAGHAERTRQLEDELRR 354
E+ + +Q E + + + R+RL + E RR+ + E E R+ ++EL+
Sbjct: 2491 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE-------EGVRRKQEELQ- 2542
Query: 355 AGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSL 414
QLE QRRQ +EL + + + + + LEE++ + E + A + +
Sbjct: 2543 ------QLEQQRRQQEELLAEENQRLRE------QLQLLEEQHRAALAHSEEVTASQVAA 2590
Query: 415 REANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQ 474
+ R A P + + S D L ++ L+E + E +RL +
Sbjct: 2591 TKTLPNGRDALDGPAAEAEPEHSF-------DGLRRKVSAQRLQEAGILSAEELQRLAQG 2643
Query: 475 EAADRE--RQEELQRHLE 490
E R+E+++ +L+
Sbjct: 2644 HTTVDELARREDVRHYLQ 2661
Score = 33.1 bits (74), Expect = 0.92
Identities = 105/481 (21%), Positives = 182/481 (37%), Gaps = 60/481 (12%)
Query: 177 YYFLSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAK 236
Y+ L E E G +L L+ E+QL E + L + L+ G
Sbjct: 329 YHPLDVEKEWG-KLHVAILEREKQLRSEFERLECLQRIVTKLQMEAG------------- 374
Query: 237 KLLLLQSQLEQ----LQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQA 292
L + QL Q LQ + L +G+ +R E+ER+ L + + L + Q
Sbjct: 375 ---LCEEQLNQADALLQSDVRLLAAGKVPQR--AGEVERD---LDKADSMIRLLFNDVQT 426
Query: 293 LKD-EMDELRQSSERAGQLEATLTSCRRR--LGELRELRRQVRQLEERNAGHAERTRQLE 349
LKD + Q R +L L + R L + Q+ + +R +LE
Sbjct: 427 LKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELE 486
Query: 350 DE-LRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLL 408
D LR L A +E + +V + +++A+ L R L + E + ER
Sbjct: 487 DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQ--LGSHRGLHQSIEEFRAKIERAR 544
Query: 409 AERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAA--EILPAELRETLLRLQL 466
++ L A L L A L+ + + +L + + A +E + +
Sbjct: 545 SDEGQLSPATRGAYRDCLGRLDLQYAK-LLNSSKARLRSLESLHSFVAAATKELMWLNEK 603
Query: 467 ENKRLC-------RQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVED 519
E + + A +E L R LE + L+ ++ R VE
Sbjct: 604 EEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVES 663
Query: 520 LQKALQEQGGKTEDAISILLKRKLEEHLQK----------LHEADLELQRKREYIEELEP 569
Q ALQ T+ + + L +E HL++ + EA+ +LQ+ +E +
Sbjct: 664 FQAALQ-----TQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYS 718
Query: 570 PTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQ--RPAAGAPPE 627
S+T R+E+L + Q + L + +A+ V+Q ++P+ P G P
Sbjct: 719 CDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQ-LKPRHPAHPMRGRLPL 777
Query: 628 L 628
L
Sbjct: 778 L 778
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 95.9 bits (237), Expect = 1e-19
Identities = 131/536 (24%), Positives = 229/536 (42%), Gaps = 94/536 (17%)
Query: 233 LTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELE---------------------R 271
LT++ + + L +++EE E R +ER R AE+E R
Sbjct: 1466 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1525
Query: 272 EVAELQHRNQ--------ALTSLAQEAQALKDEMDELRQSSE-----RAGQLEATLTSCR 318
E ELQ R Q A Q+ +++++E+ +LRQSSE +A Q EA S
Sbjct: 1526 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL 1585
Query: 319 RRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRAQLEAQRRQVQE----LQG 374
R E+R +R Q+ E + G E EL+ + + EAQ+RQ QE L+
Sbjct: 1586 RIEEEIRVVRLQLEATERQRGG-------AEGELQALRARAEEAEAQKRQAQEEAERLRR 1638
Query: 375 QRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLR----EANEELRCAQLQPRG 430
Q Q+E+ + + E + + +EK+R L + LR EA LR A+++
Sbjct: 1639 QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1698
Query: 431 LTQ---------ADPSLDPTSTPVDNLAAEILPAELRE---TLLRLQLENKRLCRQEAAD 478
Q A+ L A+ L L+E + +L+ E +R +Q+A
Sbjct: 1699 QVQVALETAQRSAEAELQSKRASFAEKTAQ-LERSLQEEHVAVAQLREEAERRAQQQAEA 1757
Query: 479 RERQEELQRHLE----DANRA-RHGLETQHRLNQQQLSELRA--QVEDLQKALQEQGGKT 531
+EE +R LE AN A R L+ + Q+ L++ A Q E+ ++ + +G
Sbjct: 1758 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1817
Query: 532 EDAI--------SILLKRKL-----------EEHLQKLHEADLELQRKREYIEE----LE 568
E A+ + +R+L E+ L +L + +++R+ +EE L+
Sbjct: 1818 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1877
Query: 569 PPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPEL 628
++T +R +EL+ L K A++ + R +++R + + + AG EL
Sbjct: 1878 REAAAATQKR-QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1936
Query: 629 HSLRTQLRE-RDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERA 683
+LR + R ++ E + QR + E++L +G A + + E A
Sbjct: 1937 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1992
Score = 90.5 bits (223), Expect = 5e-18
Identities = 155/579 (26%), Positives = 245/579 (42%), Gaps = 88/579 (15%)
Query: 182 EEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTA-----K 236
+ AEE + L + LE+Q L Q+ AQ +E R + E A +
Sbjct: 1491 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ 1550
Query: 237 KLLLLQSQLEQL-------------QEENFRLESGREDERLRCAELEREVAELQHRN--- 280
+ +Q +L+QL Q E R +E +R L+ E E Q
Sbjct: 1551 QKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1610
Query: 281 --QALTSLAQEAQALK----DEMDELRQ----SSERAGQLEATLTSCRRRLGE-LRELRR 329
QAL + A+EA+A K +E + LR+ S+R Q E L S + E RE +R
Sbjct: 1611 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1670
Query: 330 QVRQLEERNAGHAERTRQL-EDELRRAGSLRAQLE-AQRRQVQELQGQRQEEAMKAEKWL 387
++ LEE E R+L + E+ RA ++ LE AQR ELQ +R A AEK
Sbjct: 1671 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR---ASFAEKTA 1727
Query: 388 FECRNLEEKYESVTKEKERLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDN 447
R+L+E++ +V + +E AER + ++A E R +A+ L+ +
Sbjct: 1728 QLERSLQEEHVAVAQLREE--AERRAQQQAEAE--------RAREEAERELERWQLKANE 1777
Query: 448 LAAEILPAE---LRETLLRLQLENKRLCRQEAADRE------------RQEEL-QRHLED 491
L AE +++L + + E ++ E A+RE RQ EL ++ LE
Sbjct: 1778 ALRLRLQAEEVAQQKSLAQAEAEKQK----EEAEREARRRGKAEEQAVRQRELAEQELEK 1833
Query: 492 ANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDAISILLKRKLEEHLQKLH 551
+ G Q +Q+L LRA+ E EQ + + L+R+ QK
Sbjct: 1834 QRQLAEGTAQQRLAAEQELIRLRAETEQ-----GEQQRQLLEEELARLQREAAAATQKRQ 1888
Query: 552 EADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVM 611
E + EL + R +E L +S AR EE + +K L A R+R ++A +
Sbjct: 1889 ELEAELAKVRAEMEVLL----ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1944
Query: 612 QTMEPKQRPAAGAPPELHSLRTQ----LRERDVRI---RHLEMDFEKSRSQREQEEKLLI 664
E +R A + R + L E+ I L+ + E + ++E E + L
Sbjct: 1945 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLR 2004
Query: 665 SAWYNMGMALQQRAGEERAPAH---AQSFLAQQRLATNS 700
+ A Q+R EE+A H + LAQ R A++S
Sbjct: 2005 RLAED--EAFQRRRLEEQAAQHKADIEERLAQLRKASDS 2041
Score = 88.6 bits (218), Expect = 2e-17
Identities = 134/541 (24%), Positives = 226/541 (41%), Gaps = 71/541 (13%)
Query: 180 LSEEAEEGDE----LQQRCLDLERQLMLLSEEKQSLAQENAGLRERM---------GRPE 226
L E E+G++ L++ L+R+ ++++Q L E A +R M E
Sbjct: 1855 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1914
Query: 227 GEGTPGLTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAE---LQHRNQAL 283
T + ++L + +L EE RL + E+ A+ +R++AE + R +A
Sbjct: 1915 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE-----AKRQRQLAEEDAARQRAEAE 1969
Query: 284 TSLAQEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHA- 342
LA++ A+ E L+ +E A + + RRL E +R R+LEE+ A H
Sbjct: 1970 RVLAEKLAAI-GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR--RRLEEQAAQHKA 2026
Query: 343 ---ERTRQL----EDELRRAGSLRAQLEAQRRQVQE----LQGQRQEEAMKAEKWLFECR 391
ER QL + EL R L QRRQV+E L+ ++ A + E
Sbjct: 2027 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 2086
Query: 392 NLEEKYESVTKEKER--LLAERDSLREANEELRCAQLQPR------GLTQADPSLDPTST 443
+ E + KE+ L A R A EE R + + R +A
Sbjct: 2087 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2146
Query: 444 PVDNLAAEILPAELRETLLRLQLENKRLCR--QEAADRERQEELQRHLEDANRARHGLET 501
V+ L A++ E R R + E+ R + QEAA + Q E + H + L+
Sbjct: 2147 EVERLKAKV--EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2204
Query: 502 QHRLNQQQLSELRAQVEDLQKALQE-QGGKTEDAISILLKRKLEEHLQKLHEADLELQRK 560
+ Q L +LR + E ++A +E + + + R+ E ++L ++ E +
Sbjct: 2205 TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2264
Query: 561 REY----IEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEP 616
R E+L + ARR + Q L++K A A E+++++ + QT+
Sbjct: 2265 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA-ADAEMEKHKKFAE------QTLRQ 2317
Query: 617 KQRPAAGAPPELHSLRTQLRER-------DVRIRHLEMDFEKSRSQREQEEKLLISAWYN 669
K A EL +LR QL E D ++ L+ + ++ QR Q E+ L S
Sbjct: 2318 K----AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2373
Query: 670 M 670
M
Sbjct: 2374 M 2374
Score = 83.6 bits (205), Expect = 6e-16
Identities = 143/554 (25%), Positives = 223/554 (40%), Gaps = 76/554 (13%)
Query: 188 DELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQSQLEQ 247
+EL+ + + ER+L E+ Q +R E + A+K L+
Sbjct: 1676 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE---RS 1732
Query: 248 LQEENFRLESGREDERLRC---AELEREVAELQHRNQALTSLAQEAQALKDEMDELRQ-- 302
LQEE+ + RE+ R AE ER E + + A EA L+ + +E+ Q
Sbjct: 1733 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1792
Query: 303 ---SSERAGQLEATLTSCRRRLGELRELRRQVRQLEERN--------AGHAERTRQLEDE 351
+E Q E RRR G+ E + R+L E+ G A++ E E
Sbjct: 1793 SLAQAEAEKQKEEAEREARRR-GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1851
Query: 352 LRRAGSLRAQLEAQRRQVQELQGQRQEEA----------------MKAEKWLF---ECRN 392
L R + Q E QR+ ++E + Q EA ++AE + + R
Sbjct: 1852 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1911
Query: 393 LEEKYESVTKEKERLLAERDSLREANEE---LRC-AQLQPRGLTQADPSLDPTSTPVDNL 448
EE + K K+RL AE RE EE LR A+ R A+ + +
Sbjct: 1912 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1971
Query: 449 AAEILPAELRETLLRLQLENKRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQ 508
AE L A T RL+ E + +++ A+ ER L+R ED R LE Q ++
Sbjct: 1972 LAEKLAAIGEAT--RLKTEAEIALKEKEAENER---LRRLAEDEAFQRRRLEEQAAQHKA 2026
Query: 509 QLSELRAQVEDLQKA-LQEQGGKTEDAIS---------ILLKRKLEEHLQKLHEADLELQ 558
+ E AQ+ + L+ Q G ED + + LK E+ E +LEL
Sbjct: 2027 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 2086
Query: 559 RKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYV-DKARMVMQTMEPK 617
R R E D+ ++ EL+ Q++ L A EER RR ++ + + E
Sbjct: 2087 RIRSNAE------DTLRSKEQAELEAARQRQ---LAAEEERRRREAEERVQKSLAAEEEA 2137
Query: 618 QRPAAGAPPELHSLRT------QLRER--DVRIRHLEMDFEKSRSQREQEEKLLISAWYN 669
R A E+ L+ +LRER R L++ E ++ + + EEK A
Sbjct: 2138 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2197
Query: 670 MGMALQQRAGEERA 683
LQQ +E++
Sbjct: 2198 KEQELQQTLQQEQS 2211
Score = 80.9 bits (198), Expect = 4e-15
Identities = 143/623 (22%), Positives = 255/623 (40%), Gaps = 97/623 (15%)
Query: 133 QRIMTLEESVQHVVMEAIQELM-TKDTPDSLSPETYGNFDSQSRRYYFLSEEAEEGD--- 188
+R+ E++ V + QEL T S+ + G ++ R +EEAEE
Sbjct: 2182 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA----AEEAEEARVQA 2237
Query: 189 -----ELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQS 243
+ +++ + ER E+ Q+ AQ A + E E A++ L Q
Sbjct: 2238 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2297
Query: 244 QL--------EQLQEENFRLESGREDE----RLRCAELEREV----AELQHRNQALTSLA 287
Q ++ E+ R ++ E E RL+ E + + ELQ T A
Sbjct: 2298 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAA 2357
Query: 288 QEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQ 347
++ +++E+ +R E +L+A + + R L LR+ R L+E AE+ +Q
Sbjct: 2358 RQRSQVEEELFSVRVQMEELSKLKARIEAENRAL-ILRDKDNTQRFLQEE----AEKMKQ 2412
Query: 348 LEDELRRAGSLRAQLEAQRRQVQE------------LQGQRQEEAMKAEKWLFECRNLEE 395
+ +E R S+ AQ A+ RQ+ E + ++ + +A + E L++
Sbjct: 2413 VAEEAARL-SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2471
Query: 396 KYESVTKEKERLLAERDSL-REANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILP 454
+ E ++ RL +++ + ++ EE + Q Q + + + AE+
Sbjct: 2472 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2531
Query: 455 AELRET----LLRLQLEN--KRLCRQEAADRERQE-----ELQRHLED--ANRARHG--- 498
A+ R R Q E ++L R E A +E+ E+QR D A R R
Sbjct: 2532 AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2591
Query: 499 LETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDAISILLKRKLEEHLQKLHEADLELQ 558
LE + QQ+ L+ + E++Q QEQ LL+ L E D LQ
Sbjct: 2592 LEREKEKLQQEAKLLQLKSEEMQTVQQEQ----------LLQETQALQQSFLSEKDSLLQ 2641
Query: 559 RKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQ 618
R+R +IE+ ++E+L + K LR ++R ++ +++ R Q
Sbjct: 2642 RER-FIEQ--------EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQER---------Q 2683
Query: 619 RPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRA 678
R A + R + E + +R + + ++ QR Q+E+LL + LQ
Sbjct: 2684 RLVA----SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2739
Query: 679 GEERAP-AHAQSFLAQQRLATNS 700
+ RA AH++ A Q AT +
Sbjct: 2740 EQHRAALAHSEEVTASQVAATKT 2762
Score = 80.1 bits (196), Expect = 7e-15
Identities = 115/545 (21%), Positives = 226/545 (41%), Gaps = 44/545 (8%)
Query: 183 EAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQ 242
+ E E QR + ++ + + +A+ +A + + PE +L L
Sbjct: 1149 DKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTL 1208
Query: 243 SQLEQLQEENFRLESGREDERLRCAELE-REVAELQHRNQALTSLAQEAQALKDEMDELR 301
+LEQ+ R S E+L+ L R + +A +EAQA+ + EL
Sbjct: 1209 GKLEQV-----RSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELE 1263
Query: 302 QSSERAGQLEATLTSCRRRLGELRELRRQVRQLEER-NAGHAERTRQLE-------DELR 353
+ +L A + + LR+ R +++ ER H ER ++E L
Sbjct: 1264 ATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLE 1323
Query: 354 RAGSLRAQLEAQRRQVQELQGQ---RQEEAMKAEKWLFECRNLEEKYESV-----TKEKE 405
R ++ AQ + ++R++++L Q +E A WL + R +E+ +++ +E
Sbjct: 1324 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1383
Query: 406 RLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQ 465
+L E+ L E + R Q ++ + A++ P ++Q
Sbjct: 1384 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQ 1443
Query: 466 LENKRLCRQEAADRERQEEL----QRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQ 521
++ + ++ R EL ++++ + +E + RL +QQ +E R ++ +++
Sbjct: 1444 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1503
Query: 522 KALQEQGGKTE---------DAISILLKRKLEEHLQKLHEADLEL-QRKREYIEELEPPT 571
AL++Q E + + L+++++E + + EA ++ Q+KR EEL+
Sbjct: 1504 AALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR 1563
Query: 572 DSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSL 631
SS A +Q K A E R ++ R+V +E +R GA EL +L
Sbjct: 1564 QSSEA--------EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1615
Query: 632 RTQLRERDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFL 691
R + E + + R + + E+ R Q + E + A + ++ A R A L
Sbjct: 1616 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL 1675
Query: 692 AQQRL 696
+ RL
Sbjct: 1676 EELRL 1680
Score = 79.0 bits (193), Expect = 1e-14
Identities = 144/643 (22%), Positives = 255/643 (39%), Gaps = 85/643 (13%)
Query: 126 EKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYFLSEEAE 185
E D Q+ +++E +Q + + E+ K + + + + R E E
Sbjct: 1543 EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE 1602
Query: 186 ------EGD--ELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKK 237
EG+ L+ R + E Q EE + L ++ +R + E E + A+
Sbjct: 1603 RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEA 1662
Query: 238 LLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEM 297
+ Q E RL++ + RLR AE+ER Q +L ++ + E+
Sbjct: 1663 EAAREKQRALQALEELRLQAEEAERRLRQAEVER-------ARQVQVALETAQRSAEAEL 1715
Query: 298 DELRQS-SERAGQLEATLTSCRRRLGELR-ELRRQVRQLEERNAGHAERTRQLED-ELRR 354
R S +E+ QLE +L + +LR E R+ +Q E E R+LE +L+
Sbjct: 1716 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1775
Query: 355 AGSLRAQLE----AQRRQVQELQGQRQEEAM--------KAEKWLFECRNLEEKYESVTK 402
+LR +L+ AQ++ + + + ++Q+E KAE+ R L E+
Sbjct: 1776 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ----EL 1831
Query: 403 EKERLLAERDSLREANEELRCAQL--------QPRGLTQADPSLDPTSTPVDNLAAEILP 454
EK+R LAE + + E +L Q R L + + + + L
Sbjct: 1832 EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1891
Query: 455 AELRETLLRLQLENKRLCRQEAADRERQEELQRHLE-DANRARHGLETQHRL-------- 505
AEL + +++ R E R E+ ++ LE +A R R E RL
Sbjct: 1892 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1951
Query: 506 NQQQLSELRA--QVEDLQKALQEQGG--------KTEDAISILLKRKLEEHLQKLHEADL 555
Q+QL+E A Q + ++ L E+ KTE I++ K E L++L E D
Sbjct: 1952 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE-DE 2010
Query: 556 ELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTME 615
QR+R +EE + R+ +L+ + D++L ER + V+ + +E
Sbjct: 2011 AFQRRR--LEEQAAQHKADIEERLAQLR---KASDSEL----ERQKGLVEDTLRQRRQVE 2061
Query: 616 PKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQRE----QEEKLLISAWYNMG 671
E+ +L+ + LE++ + RS E +E+ + A
Sbjct: 2062 ----------EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ 2111
Query: 672 MALQQRAGEERAPAHAQSFLAQQRLATNSRRGPLGRLASLNLR 714
+A ++ A Q LA + A R+ L + L +
Sbjct: 2112 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2154
Score = 70.9 bits (172), Expect = 4e-12
Identities = 114/468 (24%), Positives = 195/468 (41%), Gaps = 62/468 (13%)
Query: 181 SEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLL 240
+E A + ++++ + Q+ LS+ K + EN L R T + L
Sbjct: 2354 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR--------DKDNTQRFLQE 2405
Query: 241 LQSQLEQLQEENFRLE-SGREDERLRCAELE-----REVAE--LQHRNQALTSLAQEAQA 292
+++Q+ EE RL + +E RLR E R +AE L+ + QA+ QEA
Sbjct: 2406 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAV----QEATR 2461
Query: 293 LKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDEL 352
LK E + L+Q E A + RRL E +E + +QL E G R LE E
Sbjct: 2462 LKAEAELLQQQKELAQEQA-------RRLQEDKE--QMAQQLAEETQGFQ---RTLEAER 2509
Query: 353 RRAGSLRAQLEAQRRQVQEL---QGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLA 409
+R + A+ E + +V E+ Q + +E+A + K E + E T+EK L+
Sbjct: 2510 QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2569
Query: 410 ERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENK 469
+ R+ Q+D + + L E + LL+L+ E
Sbjct: 2570 TLEIQRQ----------------QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2613
Query: 470 RLCRQEAADRERQEELQRHLEDAN---RARHGLETQHRLNQQQLSELRAQVEDLQKALQE 526
+ +QE +E Q Q L + + + +E + +Q + A+ + L++ Q
Sbjct: 2614 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2673
Query: 527 QGGKTEDAISILLKRKLEEHLQKLHEADLELQRKREYIEELEPPT---DSSTARRIEELQ 583
Q + E L+ +EE ++ HEA+ ++RK+E +++LE + A + L+
Sbjct: 2674 QQQQMEQERQRLVA-SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2732
Query: 584 HNLQKKDADLRAM----EERYRRYVDKARMVMQTMEPKQRPAAGAPPE 627
LQ + RA EE V + + + PAA A PE
Sbjct: 2733 EQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2780
Score = 54.3 bits (129), Expect = 4e-07
Identities = 100/471 (21%), Positives = 180/471 (38%), Gaps = 97/471 (20%)
Query: 299 ELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERN-------------------- 338
+L QS E+ Q E+ C+R + EL+++R Q+ E R
Sbjct: 1104 QLLQSLEQGAQEESR---CQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRI 1160
Query: 339 --------------------AGHAERTRQLEDELRRAGSLRAQLEAQRRQVQELQG---- 374
+ AE+ L + A +LR++LE ++++++
Sbjct: 1161 AEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1220
Query: 375 ---------------QRQEEAMKA-EKWLFECR-------NLEEKYESVTKEKERLLAER 411
Q EE ++A E+ L E + LE S+ K + + A++
Sbjct: 1221 YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQ 1280
Query: 412 DSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEIL---PAELRETLLRLQLEN 468
+ +ELR AQ L Q D A++L A L +T +R Q E
Sbjct: 1281 PTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVR-QREL 1339
Query: 469 KRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQG 528
++L RQ RE + L L+DA R + ++ + Q + E Q + L + ++ G
Sbjct: 1340 EQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHG 1399
Query: 529 GKTEDAISILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQK 588
K E+ +R ++++ + + +L+L Y +LEP + +++ ++ +
Sbjct: 1400 EKVEEC-----QRFAKQYINAIKDYELQLV---TYKAQLEPVASPAKKPKVQSGSESVIQ 1451
Query: 589 KDADLRA----MEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRH 644
+ DLR + +Y+ ++ ME ++R A Q E R+
Sbjct: 1452 EYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLA----------EQQRAEERERLAE 1501
Query: 645 LEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQR 695
+E EK R E + A LQQR EE + AQQ+
Sbjct: 1502 VEAALEKQRQLAEAHAQAKAQA-EREAKELQQRMQEEVVRREEAAVDAQQQ 1551
Score = 49.3 bits (116), Expect = 1e-05
Identities = 87/378 (23%), Positives = 152/378 (40%), Gaps = 90/378 (23%)
Query: 162 LSPETYG---NFDSQSRRYYFLSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGL 218
L+ ET G +++ +R +S EAE L+ R ++ R E+ Q ++ +
Sbjct: 2494 LAEETQGFQRTLEAERQRQLEMSAEAER---LKLRVAEMSRAQARAEEDAQRFRKQAEEI 2550
Query: 219 RERMGRPEGEGTPGLTAKKLLLLQSQLEQLQEENFRLESGREDERLR--CAELEREVAEL 276
E++ R E T +K+ L+Q+ Q Q+ S + ERLR AELERE +L
Sbjct: 2551 GEKLHRTELA-----TQEKVTLVQTLEIQRQQ------SDHDAERLREAIAELEREKEKL 2599
Query: 277 QHRNQALT------------SLAQEAQALK-----------------------------D 295
Q + L L QE QAL+ D
Sbjct: 2600 QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2659
Query: 296 EMDELRQSSERAGQLEATLTSCRRRL-GELRELRRQVRQLEERNAGHAERTRQLEDELRR 354
E+ + +Q E + + + R+RL + E RR+ + E E R+ ++EL+
Sbjct: 2660 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE-------EGVRRKQEELQ- 2711
Query: 355 AGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSL 414
QLE QRRQ +EL + + + + + LEE++ + E + A + +
Sbjct: 2712 ------QLEQQRRQQEELLAEENQRLRE------QLQLLEEQHRAALAHSEEVTASQVAA 2759
Query: 415 REANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQ 474
+ R A P + + S D L ++ L+E + E +RL +
Sbjct: 2760 TKTLPNGRDALDGPAAEAEPEHSF-------DGLRRKVSAQRLQEAGILSAEELQRLAQG 2812
Query: 475 EAADRE--RQEELQRHLE 490
E R+E+++ +L+
Sbjct: 2813 HTTVDELARREDVRHYLQ 2830
Score = 33.1 bits (74), Expect = 0.92
Identities = 105/481 (21%), Positives = 182/481 (37%), Gaps = 60/481 (12%)
Query: 177 YYFLSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAK 236
Y+ L E E G +L L+ E+QL E + L + L+ G
Sbjct: 498 YHPLDVEKEWG-KLHVAILEREKQLRSEFERLECLQRIVTKLQMEAG------------- 543
Query: 237 KLLLLQSQLEQ----LQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQA 292
L + QL Q LQ + L +G+ +R E+ER+ L + + L + Q
Sbjct: 544 ---LCEEQLNQADALLQSDVRLLAAGKVPQR--AGEVERD---LDKADSMIRLLFNDVQT 595
Query: 293 LKD-EMDELRQSSERAGQLEATLTSCRRR--LGELRELRRQVRQLEERNAGHAERTRQLE 349
LKD + Q R +L L + R L + Q+ + +R +LE
Sbjct: 596 LKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELE 655
Query: 350 DE-LRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLL 408
D LR L A +E + +V + +++A+ L R L + E + ER
Sbjct: 656 DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQ--LGSHRGLHQSIEEFRAKIERAR 713
Query: 409 AERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAA--EILPAELRETLLRLQL 466
++ L A L L A L+ + + +L + + A +E + +
Sbjct: 714 SDEGQLSPATRGAYRDCLGRLDLQYAK-LLNSSKARLRSLESLHSFVAAATKELMWLNEK 772
Query: 467 ENKRLC-------RQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVED 519
E + + A +E L R LE + L+ ++ R VE
Sbjct: 773 EEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVES 832
Query: 520 LQKALQEQGGKTEDAISILLKRKLEEHLQK----------LHEADLELQRKREYIEELEP 569
Q ALQ T+ + + L +E HL++ + EA+ +LQ+ +E +
Sbjct: 833 FQAALQ-----TQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYS 887
Query: 570 PTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQ--RPAAGAPPE 627
S+T R+E+L + Q + L + +A+ V+Q ++P+ P G P
Sbjct: 888 CDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQ-LKPRHPAHPMRGRLPL 946
Query: 628 L 628
L
Sbjct: 947 L 947
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 95.9 bits (237), Expect = 1e-19
Identities = 131/536 (24%), Positives = 229/536 (42%), Gaps = 94/536 (17%)
Query: 233 LTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELE---------------------R 271
LT++ + + L +++EE E R +ER R AE+E R
Sbjct: 1307 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1366
Query: 272 EVAELQHRNQ--------ALTSLAQEAQALKDEMDELRQSSE-----RAGQLEATLTSCR 318
E ELQ R Q A Q+ +++++E+ +LRQSSE +A Q EA S
Sbjct: 1367 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL 1426
Query: 319 RRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRAQLEAQRRQVQE----LQG 374
R E+R +R Q+ E + G E EL+ + + EAQ+RQ QE L+
Sbjct: 1427 RIEEEIRVVRLQLEATERQRGG-------AEGELQALRARAEEAEAQKRQAQEEAERLRR 1479
Query: 375 QRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLR----EANEELRCAQLQPRG 430
Q Q+E+ + + E + + +EK+R L + LR EA LR A+++
Sbjct: 1480 QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1539
Query: 431 LTQ---------ADPSLDPTSTPVDNLAAEILPAELRE---TLLRLQLENKRLCRQEAAD 478
Q A+ L A+ L L+E + +L+ E +R +Q+A
Sbjct: 1540 QVQVALETAQRSAEAELQSKRASFAEKTAQ-LERSLQEEHVAVAQLREEAERRAQQQAEA 1598
Query: 479 RERQEELQRHLE----DANRA-RHGLETQHRLNQQQLSELRA--QVEDLQKALQEQGGKT 531
+EE +R LE AN A R L+ + Q+ L++ A Q E+ ++ + +G
Sbjct: 1599 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1658
Query: 532 EDAI--------SILLKRKL-----------EEHLQKLHEADLELQRKREYIEE----LE 568
E A+ + +R+L E+ L +L + +++R+ +EE L+
Sbjct: 1659 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1718
Query: 569 PPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPEL 628
++T +R +EL+ L K A++ + R +++R + + + AG EL
Sbjct: 1719 REAAAATQKR-QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1777
Query: 629 HSLRTQLRE-RDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERA 683
+LR + R ++ E + QR + E++L +G A + + E A
Sbjct: 1778 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1833
Score = 90.5 bits (223), Expect = 5e-18
Identities = 155/579 (26%), Positives = 245/579 (42%), Gaps = 88/579 (15%)
Query: 182 EEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTA-----K 236
+ AEE + L + LE+Q L Q+ AQ +E R + E A +
Sbjct: 1332 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ 1391
Query: 237 KLLLLQSQLEQL-------------QEENFRLESGREDERLRCAELEREVAELQHRN--- 280
+ +Q +L+QL Q E R +E +R L+ E E Q
Sbjct: 1392 QKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1451
Query: 281 --QALTSLAQEAQALK----DEMDELRQ----SSERAGQLEATLTSCRRRLGE-LRELRR 329
QAL + A+EA+A K +E + LR+ S+R Q E L S + E RE +R
Sbjct: 1452 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1511
Query: 330 QVRQLEERNAGHAERTRQL-EDELRRAGSLRAQLE-AQRRQVQELQGQRQEEAMKAEKWL 387
++ LEE E R+L + E+ RA ++ LE AQR ELQ +R A AEK
Sbjct: 1512 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR---ASFAEKTA 1568
Query: 388 FECRNLEEKYESVTKEKERLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDN 447
R+L+E++ +V + +E AER + ++A E R +A+ L+ +
Sbjct: 1569 QLERSLQEEHVAVAQLREE--AERRAQQQAEAE--------RAREEAERELERWQLKANE 1618
Query: 448 LAAEILPAE---LRETLLRLQLENKRLCRQEAADRE------------RQEEL-QRHLED 491
L AE +++L + + E ++ E A+RE RQ EL ++ LE
Sbjct: 1619 ALRLRLQAEEVAQQKSLAQAEAEKQK----EEAEREARRRGKAEEQAVRQRELAEQELEK 1674
Query: 492 ANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDAISILLKRKLEEHLQKLH 551
+ G Q +Q+L LRA+ E EQ + + L+R+ QK
Sbjct: 1675 QRQLAEGTAQQRLAAEQELIRLRAETEQ-----GEQQRQLLEEELARLQREAAAATQKRQ 1729
Query: 552 EADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVM 611
E + EL + R +E L +S AR EE + +K L A R+R ++A +
Sbjct: 1730 ELEAELAKVRAEMEVLL----ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1785
Query: 612 QTMEPKQRPAAGAPPELHSLRTQ----LRERDVRI---RHLEMDFEKSRSQREQEEKLLI 664
E +R A + R + L E+ I L+ + E + ++E E + L
Sbjct: 1786 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLR 1845
Query: 665 SAWYNMGMALQQRAGEERAPAH---AQSFLAQQRLATNS 700
+ A Q+R EE+A H + LAQ R A++S
Sbjct: 1846 RLAED--EAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1882
Score = 88.6 bits (218), Expect = 2e-17
Identities = 134/541 (24%), Positives = 226/541 (41%), Gaps = 71/541 (13%)
Query: 180 LSEEAEEGDE----LQQRCLDLERQLMLLSEEKQSLAQENAGLRERM---------GRPE 226
L E E+G++ L++ L+R+ ++++Q L E A +R M E
Sbjct: 1696 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1755
Query: 227 GEGTPGLTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAE---LQHRNQAL 283
T + ++L + +L EE RL + E+ A+ +R++AE + R +A
Sbjct: 1756 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE-----AKRQRQLAEEDAARQRAEAE 1810
Query: 284 TSLAQEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHA- 342
LA++ A+ E L+ +E A + + RRL E +R R+LEE+ A H
Sbjct: 1811 RVLAEKLAAI-GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR--RRLEEQAAQHKA 1867
Query: 343 ---ERTRQL----EDELRRAGSLRAQLEAQRRQVQE----LQGQRQEEAMKAEKWLFECR 391
ER QL + EL R L QRRQV+E L+ ++ A + E
Sbjct: 1868 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1927
Query: 392 NLEEKYESVTKEKER--LLAERDSLREANEELRCAQLQPR------GLTQADPSLDPTST 443
+ E + KE+ L A R A EE R + + R +A
Sbjct: 1928 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 1987
Query: 444 PVDNLAAEILPAELRETLLRLQLENKRLCR--QEAADRERQEELQRHLEDANRARHGLET 501
V+ L A++ E R R + E+ R + QEAA + Q E + H + L+
Sbjct: 1988 EVERLKAKV--EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2045
Query: 502 QHRLNQQQLSELRAQVEDLQKALQE-QGGKTEDAISILLKRKLEEHLQKLHEADLELQRK 560
+ Q L +LR + E ++A +E + + + R+ E ++L ++ E +
Sbjct: 2046 TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2105
Query: 561 REY----IEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEP 616
R E+L + ARR + Q L++K A A E+++++ + QT+
Sbjct: 2106 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA-ADAEMEKHKKFAE------QTLRQ 2158
Query: 617 KQRPAAGAPPELHSLRTQLRER-------DVRIRHLEMDFEKSRSQREQEEKLLISAWYN 669
K A EL +LR QL E D ++ L+ + ++ QR Q E+ L S
Sbjct: 2159 K----AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2214
Query: 670 M 670
M
Sbjct: 2215 M 2215
Score = 83.6 bits (205), Expect = 6e-16
Identities = 143/554 (25%), Positives = 223/554 (40%), Gaps = 76/554 (13%)
Query: 188 DELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQSQLEQ 247
+EL+ + + ER+L E+ Q +R E + A+K L+
Sbjct: 1517 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE---RS 1573
Query: 248 LQEENFRLESGREDERLRC---AELEREVAELQHRNQALTSLAQEAQALKDEMDELRQ-- 302
LQEE+ + RE+ R AE ER E + + A EA L+ + +E+ Q
Sbjct: 1574 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1633
Query: 303 ---SSERAGQLEATLTSCRRRLGELRELRRQVRQLEERN--------AGHAERTRQLEDE 351
+E Q E RRR G+ E + R+L E+ G A++ E E
Sbjct: 1634 SLAQAEAEKQKEEAEREARRR-GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1692
Query: 352 LRRAGSLRAQLEAQRRQVQELQGQRQEEA----------------MKAEKWLF---ECRN 392
L R + Q E QR+ ++E + Q EA ++AE + + R
Sbjct: 1693 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1752
Query: 393 LEEKYESVTKEKERLLAERDSLREANEE---LRC-AQLQPRGLTQADPSLDPTSTPVDNL 448
EE + K K+RL AE RE EE LR A+ R A+ + +
Sbjct: 1753 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1812
Query: 449 AAEILPAELRETLLRLQLENKRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQ 508
AE L A T RL+ E + +++ A+ ER L+R ED R LE Q ++
Sbjct: 1813 LAEKLAAIGEAT--RLKTEAEIALKEKEAENER---LRRLAEDEAFQRRRLEEQAAQHKA 1867
Query: 509 QLSELRAQVEDLQKA-LQEQGGKTEDAIS---------ILLKRKLEEHLQKLHEADLELQ 558
+ E AQ+ + L+ Q G ED + + LK E+ E +LEL
Sbjct: 1868 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1927
Query: 559 RKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYV-DKARMVMQTMEPK 617
R R E D+ ++ EL+ Q++ L A EER RR ++ + + E
Sbjct: 1928 RIRSNAE------DTLRSKEQAELEAARQRQ---LAAEEERRRREAEERVQKSLAAEEEA 1978
Query: 618 QRPAAGAPPELHSLRT------QLRER--DVRIRHLEMDFEKSRSQREQEEKLLISAWYN 669
R A E+ L+ +LRER R L++ E ++ + + EEK A
Sbjct: 1979 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2038
Query: 670 MGMALQQRAGEERA 683
LQQ +E++
Sbjct: 2039 KEQELQQTLQQEQS 2052
Score = 80.9 bits (198), Expect = 4e-15
Identities = 143/623 (22%), Positives = 255/623 (40%), Gaps = 97/623 (15%)
Query: 133 QRIMTLEESVQHVVMEAIQELM-TKDTPDSLSPETYGNFDSQSRRYYFLSEEAEEGD--- 188
+R+ E++ V + QEL T S+ + G ++ R +EEAEE
Sbjct: 2023 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA----AEEAEEARVQA 2078
Query: 189 -----ELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQS 243
+ +++ + ER E+ Q+ AQ A + E E A++ L Q
Sbjct: 2079 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2138
Query: 244 QL--------EQLQEENFRLESGREDE----RLRCAELEREV----AELQHRNQALTSLA 287
Q ++ E+ R ++ E E RL+ E + + ELQ T A
Sbjct: 2139 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAA 2198
Query: 288 QEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQ 347
++ +++E+ +R E +L+A + + R L LR+ R L+E AE+ +Q
Sbjct: 2199 RQRSQVEEELFSVRVQMEELSKLKARIEAENRAL-ILRDKDNTQRFLQEE----AEKMKQ 2253
Query: 348 LEDELRRAGSLRAQLEAQRRQVQE------------LQGQRQEEAMKAEKWLFECRNLEE 395
+ +E R S+ AQ A+ RQ+ E + ++ + +A + E L++
Sbjct: 2254 VAEEAARL-SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2312
Query: 396 KYESVTKEKERLLAERDSL-REANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILP 454
+ E ++ RL +++ + ++ EE + Q Q + + + AE+
Sbjct: 2313 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2372
Query: 455 AELRET----LLRLQLEN--KRLCRQEAADRERQE-----ELQRHLED--ANRARHG--- 498
A+ R R Q E ++L R E A +E+ E+QR D A R R
Sbjct: 2373 AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2432
Query: 499 LETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDAISILLKRKLEEHLQKLHEADLELQ 558
LE + QQ+ L+ + E++Q QEQ LL+ L E D LQ
Sbjct: 2433 LEREKEKLQQEAKLLQLKSEEMQTVQQEQ----------LLQETQALQQSFLSEKDSLLQ 2482
Query: 559 RKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQ 618
R+R +IE+ ++E+L + K LR ++R ++ +++ R Q
Sbjct: 2483 RER-FIEQ--------EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQER---------Q 2524
Query: 619 RPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRA 678
R A + R + E + +R + + ++ QR Q+E+LL + LQ
Sbjct: 2525 RLVA----SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2580
Query: 679 GEERAP-AHAQSFLAQQRLATNS 700
+ RA AH++ A Q AT +
Sbjct: 2581 EQHRAALAHSEEVTASQVAATKT 2603
Score = 80.1 bits (196), Expect = 7e-15
Identities = 115/545 (21%), Positives = 226/545 (41%), Gaps = 44/545 (8%)
Query: 183 EAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQ 242
+ E E QR + ++ + + +A+ +A + + PE +L L
Sbjct: 990 DKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTL 1049
Query: 243 SQLEQLQEENFRLESGREDERLRCAELE-REVAELQHRNQALTSLAQEAQALKDEMDELR 301
+LEQ+ R S E+L+ L R + +A +EAQA+ + EL
Sbjct: 1050 GKLEQV-----RSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELE 1104
Query: 302 QSSERAGQLEATLTSCRRRLGELRELRRQVRQLEER-NAGHAERTRQLE-------DELR 353
+ +L A + + LR+ R +++ ER H ER ++E L
Sbjct: 1105 ATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLE 1164
Query: 354 RAGSLRAQLEAQRRQVQELQGQ---RQEEAMKAEKWLFECRNLEEKYESV-----TKEKE 405
R ++ AQ + ++R++++L Q +E A WL + R +E+ +++ +E
Sbjct: 1165 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1224
Query: 406 RLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQ 465
+L E+ L E + R Q ++ + A++ P ++Q
Sbjct: 1225 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQ 1284
Query: 466 LENKRLCRQEAADRERQEEL----QRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQ 521
++ + ++ R EL ++++ + +E + RL +QQ +E R ++ +++
Sbjct: 1285 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1344
Query: 522 KALQEQGGKTE---------DAISILLKRKLEEHLQKLHEADLEL-QRKREYIEELEPPT 571
AL++Q E + + L+++++E + + EA ++ Q+KR EEL+
Sbjct: 1345 AALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR 1404
Query: 572 DSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSL 631
SS A +Q K A E R ++ R+V +E +R GA EL +L
Sbjct: 1405 QSSEA--------EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1456
Query: 632 RTQLRERDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFL 691
R + E + + R + + E+ R Q + E + A + ++ A R A L
Sbjct: 1457 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL 1516
Query: 692 AQQRL 696
+ RL
Sbjct: 1517 EELRL 1521
Score = 79.0 bits (193), Expect = 1e-14
Identities = 144/643 (22%), Positives = 255/643 (39%), Gaps = 85/643 (13%)
Query: 126 EKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYFLSEEAE 185
E D Q+ +++E +Q + + E+ K + + + + R E E
Sbjct: 1384 EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE 1443
Query: 186 ------EGD--ELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKK 237
EG+ L+ R + E Q EE + L ++ +R + E E + A+
Sbjct: 1444 RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEA 1503
Query: 238 LLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEM 297
+ Q E RL++ + RLR AE+ER Q +L ++ + E+
Sbjct: 1504 EAAREKQRALQALEELRLQAEEAERRLRQAEVER-------ARQVQVALETAQRSAEAEL 1556
Query: 298 DELRQS-SERAGQLEATLTSCRRRLGELR-ELRRQVRQLEERNAGHAERTRQLED-ELRR 354
R S +E+ QLE +L + +LR E R+ +Q E E R+LE +L+
Sbjct: 1557 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1616
Query: 355 AGSLRAQLE----AQRRQVQELQGQRQEEAM--------KAEKWLFECRNLEEKYESVTK 402
+LR +L+ AQ++ + + + ++Q+E KAE+ R L E+
Sbjct: 1617 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ----EL 1672
Query: 403 EKERLLAERDSLREANEELRCAQL--------QPRGLTQADPSLDPTSTPVDNLAAEILP 454
EK+R LAE + + E +L Q R L + + + + L
Sbjct: 1673 EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1732
Query: 455 AELRETLLRLQLENKRLCRQEAADRERQEELQRHLE-DANRARHGLETQHRL-------- 505
AEL + +++ R E R E+ ++ LE +A R R E RL
Sbjct: 1733 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1792
Query: 506 NQQQLSELRA--QVEDLQKALQEQGG--------KTEDAISILLKRKLEEHLQKLHEADL 555
Q+QL+E A Q + ++ L E+ KTE I++ K E L++L E D
Sbjct: 1793 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE-DE 1851
Query: 556 ELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTME 615
QR+R +EE + R+ +L+ + D++L ER + V+ + +E
Sbjct: 1852 AFQRRR--LEEQAAQHKADIEERLAQLR---KASDSEL----ERQKGLVEDTLRQRRQVE 1902
Query: 616 PKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQRE----QEEKLLISAWYNMG 671
E+ +L+ + LE++ + RS E +E+ + A
Sbjct: 1903 ----------EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ 1952
Query: 672 MALQQRAGEERAPAHAQSFLAQQRLATNSRRGPLGRLASLNLR 714
+A ++ A Q LA + A R+ L + L +
Sbjct: 1953 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 1995
Score = 70.9 bits (172), Expect = 4e-12
Identities = 114/468 (24%), Positives = 195/468 (41%), Gaps = 62/468 (13%)
Query: 181 SEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLL 240
+E A + ++++ + Q+ LS+ K + EN L R T + L
Sbjct: 2195 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR--------DKDNTQRFLQE 2246
Query: 241 LQSQLEQLQEENFRLE-SGREDERLRCAELE-----REVAE--LQHRNQALTSLAQEAQA 292
+++Q+ EE RL + +E RLR E R +AE L+ + QA+ QEA
Sbjct: 2247 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAV----QEATR 2302
Query: 293 LKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDEL 352
LK E + L+Q E A + RRL E +E + +QL E G R LE E
Sbjct: 2303 LKAEAELLQQQKELAQEQA-------RRLQEDKE--QMAQQLAEETQGFQ---RTLEAER 2350
Query: 353 RRAGSLRAQLEAQRRQVQEL---QGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLA 409
+R + A+ E + +V E+ Q + +E+A + K E + E T+EK L+
Sbjct: 2351 QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2410
Query: 410 ERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENK 469
+ R+ Q+D + + L E + LL+L+ E
Sbjct: 2411 TLEIQRQ----------------QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2454
Query: 470 RLCRQEAADRERQEELQRHLEDAN---RARHGLETQHRLNQQQLSELRAQVEDLQKALQE 526
+ +QE +E Q Q L + + + +E + +Q + A+ + L++ Q
Sbjct: 2455 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2514
Query: 527 QGGKTEDAISILLKRKLEEHLQKLHEADLELQRKREYIEELEPPT---DSSTARRIEELQ 583
Q + E L+ +EE ++ HEA+ ++RK+E +++LE + A + L+
Sbjct: 2515 QQQQMEQERQRLVA-SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2573
Query: 584 HNLQKKDADLRAM----EERYRRYVDKARMVMQTMEPKQRPAAGAPPE 627
LQ + RA EE V + + + PAA A PE
Sbjct: 2574 EQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2621
Score = 54.3 bits (129), Expect = 4e-07
Identities = 100/471 (21%), Positives = 180/471 (38%), Gaps = 97/471 (20%)
Query: 299 ELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERN-------------------- 338
+L QS E+ Q E+ C+R + EL+++R Q+ E R
Sbjct: 945 QLLQSLEQGAQEESR---CQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRI 1001
Query: 339 --------------------AGHAERTRQLEDELRRAGSLRAQLEAQRRQVQELQG---- 374
+ AE+ L + A +LR++LE ++++++
Sbjct: 1002 AEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1061
Query: 375 ---------------QRQEEAMKA-EKWLFECR-------NLEEKYESVTKEKERLLAER 411
Q EE ++A E+ L E + LE S+ K + + A++
Sbjct: 1062 YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQ 1121
Query: 412 DSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEIL---PAELRETLLRLQLEN 468
+ +ELR AQ L Q D A++L A L +T +R Q E
Sbjct: 1122 PTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVR-QREL 1180
Query: 469 KRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQG 528
++L RQ RE + L L+DA R + ++ + Q + E Q + L + ++ G
Sbjct: 1181 EQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHG 1240
Query: 529 GKTEDAISILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQK 588
K E+ +R ++++ + + +L+L Y +LEP + +++ ++ +
Sbjct: 1241 EKVEEC-----QRFAKQYINAIKDYELQLV---TYKAQLEPVASPAKKPKVQSGSESVIQ 1292
Query: 589 KDADLRA----MEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRH 644
+ DLR + +Y+ ++ ME ++R A Q E R+
Sbjct: 1293 EYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLA----------EQQRAEERERLAE 1342
Query: 645 LEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQR 695
+E EK R E + A LQQR EE + AQQ+
Sbjct: 1343 VEAALEKQRQLAEAHAQAKAQA-EREAKELQQRMQEEVVRREEAAVDAQQQ 1392
Score = 49.3 bits (116), Expect = 1e-05
Identities = 87/378 (23%), Positives = 152/378 (40%), Gaps = 90/378 (23%)
Query: 162 LSPETYG---NFDSQSRRYYFLSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGL 218
L+ ET G +++ +R +S EAE L+ R ++ R E+ Q ++ +
Sbjct: 2335 LAEETQGFQRTLEAERQRQLEMSAEAER---LKLRVAEMSRAQARAEEDAQRFRKQAEEI 2391
Query: 219 RERMGRPEGEGTPGLTAKKLLLLQSQLEQLQEENFRLESGREDERLR--CAELEREVAEL 276
E++ R E T +K+ L+Q+ Q Q+ S + ERLR AELERE +L
Sbjct: 2392 GEKLHRTELA-----TQEKVTLVQTLEIQRQQ------SDHDAERLREAIAELEREKEKL 2440
Query: 277 QHRNQALT------------SLAQEAQALK-----------------------------D 295
Q + L L QE QAL+ D
Sbjct: 2441 QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2500
Query: 296 EMDELRQSSERAGQLEATLTSCRRRL-GELRELRRQVRQLEERNAGHAERTRQLEDELRR 354
E+ + +Q E + + + R+RL + E RR+ + E E R+ ++EL+
Sbjct: 2501 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE-------EGVRRKQEELQ- 2552
Query: 355 AGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSL 414
QLE QRRQ +EL + + + + + LEE++ + E + A + +
Sbjct: 2553 ------QLEQQRRQQEELLAEENQRLRE------QLQLLEEQHRAALAHSEEVTASQVAA 2600
Query: 415 REANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQ 474
+ R A P + + S D L ++ L+E + E +RL +
Sbjct: 2601 TKTLPNGRDALDGPAAEAEPEHSF-------DGLRRKVSAQRLQEAGILSAEELQRLAQG 2653
Query: 475 EAADRE--RQEELQRHLE 490
E R+E+++ +L+
Sbjct: 2654 HTTVDELARREDVRHYLQ 2671
Score = 33.1 bits (74), Expect = 0.92
Identities = 105/481 (21%), Positives = 182/481 (37%), Gaps = 60/481 (12%)
Query: 177 YYFLSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAK 236
Y+ L E E G +L L+ E+QL E + L + L+ G
Sbjct: 339 YHPLDVEKEWG-KLHVAILEREKQLRSEFERLECLQRIVTKLQMEAG------------- 384
Query: 237 KLLLLQSQLEQ----LQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQA 292
L + QL Q LQ + L +G+ +R E+ER+ L + + L + Q
Sbjct: 385 ---LCEEQLNQADALLQSDVRLLAAGKVPQR--AGEVERD---LDKADSMIRLLFNDVQT 436
Query: 293 LKD-EMDELRQSSERAGQLEATLTSCRRR--LGELRELRRQVRQLEERNAGHAERTRQLE 349
LKD + Q R +L L + R L + Q+ + +R +LE
Sbjct: 437 LKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELE 496
Query: 350 DE-LRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLL 408
D LR L A +E + +V + +++A+ L R L + E + ER
Sbjct: 497 DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQ--LGSHRGLHQSIEEFRAKIERAR 554
Query: 409 AERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAA--EILPAELRETLLRLQL 466
++ L A L L A L+ + + +L + + A +E + +
Sbjct: 555 SDEGQLSPATRGAYRDCLGRLDLQYAK-LLNSSKARLRSLESLHSFVAAATKELMWLNEK 613
Query: 467 ENKRLC-------RQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVED 519
E + + A +E L R LE + L+ ++ R VE
Sbjct: 614 EEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVES 673
Query: 520 LQKALQEQGGKTEDAISILLKRKLEEHLQK----------LHEADLELQRKREYIEELEP 569
Q ALQ T+ + + L +E HL++ + EA+ +LQ+ +E +
Sbjct: 674 FQAALQ-----TQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYS 728
Query: 570 PTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQ--RPAAGAPPE 627
S+T R+E+L + Q + L + +A+ V+Q ++P+ P G P
Sbjct: 729 CDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQ-LKPRHPAHPMRGRLPL 787
Query: 628 L 628
L
Sbjct: 788 L 788
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 95.9 bits (237), Expect = 1e-19
Identities = 131/536 (24%), Positives = 229/536 (42%), Gaps = 94/536 (17%)
Query: 233 LTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELE---------------------R 271
LT++ + + L +++EE E R +ER R AE+E R
Sbjct: 1315 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1374
Query: 272 EVAELQHRNQ--------ALTSLAQEAQALKDEMDELRQSSE-----RAGQLEATLTSCR 318
E ELQ R Q A Q+ +++++E+ +LRQSSE +A Q EA S
Sbjct: 1375 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL 1434
Query: 319 RRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRAQLEAQRRQVQE----LQG 374
R E+R +R Q+ E + G E EL+ + + EAQ+RQ QE L+
Sbjct: 1435 RIEEEIRVVRLQLEATERQRGG-------AEGELQALRARAEEAEAQKRQAQEEAERLRR 1487
Query: 375 QRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLR----EANEELRCAQLQPRG 430
Q Q+E+ + + E + + +EK+R L + LR EA LR A+++
Sbjct: 1488 QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1547
Query: 431 LTQ---------ADPSLDPTSTPVDNLAAEILPAELRE---TLLRLQLENKRLCRQEAAD 478
Q A+ L A+ L L+E + +L+ E +R +Q+A
Sbjct: 1548 QVQVALETAQRSAEAELQSKRASFAEKTAQ-LERSLQEEHVAVAQLREEAERRAQQQAEA 1606
Query: 479 RERQEELQRHLE----DANRA-RHGLETQHRLNQQQLSELRA--QVEDLQKALQEQGGKT 531
+EE +R LE AN A R L+ + Q+ L++ A Q E+ ++ + +G
Sbjct: 1607 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1666
Query: 532 EDAI--------SILLKRKL-----------EEHLQKLHEADLELQRKREYIEE----LE 568
E A+ + +R+L E+ L +L + +++R+ +EE L+
Sbjct: 1667 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1726
Query: 569 PPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPEL 628
++T +R +EL+ L K A++ + R +++R + + + AG EL
Sbjct: 1727 REAAAATQKR-QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1785
Query: 629 HSLRTQLRE-RDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERA 683
+LR + R ++ E + QR + E++L +G A + + E A
Sbjct: 1786 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1841
Score = 90.5 bits (223), Expect = 5e-18
Identities = 155/579 (26%), Positives = 245/579 (42%), Gaps = 88/579 (15%)
Query: 182 EEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTA-----K 236
+ AEE + L + LE+Q L Q+ AQ +E R + E A +
Sbjct: 1340 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ 1399
Query: 237 KLLLLQSQLEQL-------------QEENFRLESGREDERLRCAELEREVAELQHRN--- 280
+ +Q +L+QL Q E R +E +R L+ E E Q
Sbjct: 1400 QKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1459
Query: 281 --QALTSLAQEAQALK----DEMDELRQ----SSERAGQLEATLTSCRRRLGE-LRELRR 329
QAL + A+EA+A K +E + LR+ S+R Q E L S + E RE +R
Sbjct: 1460 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1519
Query: 330 QVRQLEERNAGHAERTRQL-EDELRRAGSLRAQLE-AQRRQVQELQGQRQEEAMKAEKWL 387
++ LEE E R+L + E+ RA ++ LE AQR ELQ +R A AEK
Sbjct: 1520 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR---ASFAEKTA 1576
Query: 388 FECRNLEEKYESVTKEKERLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDN 447
R+L+E++ +V + +E AER + ++A E R +A+ L+ +
Sbjct: 1577 QLERSLQEEHVAVAQLREE--AERRAQQQAEAE--------RAREEAERELERWQLKANE 1626
Query: 448 LAAEILPAE---LRETLLRLQLENKRLCRQEAADRE------------RQEEL-QRHLED 491
L AE +++L + + E ++ E A+RE RQ EL ++ LE
Sbjct: 1627 ALRLRLQAEEVAQQKSLAQAEAEKQK----EEAEREARRRGKAEEQAVRQRELAEQELEK 1682
Query: 492 ANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDAISILLKRKLEEHLQKLH 551
+ G Q +Q+L LRA+ E EQ + + L+R+ QK
Sbjct: 1683 QRQLAEGTAQQRLAAEQELIRLRAETEQ-----GEQQRQLLEEELARLQREAAAATQKRQ 1737
Query: 552 EADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVM 611
E + EL + R +E L +S AR EE + +K L A R+R ++A +
Sbjct: 1738 ELEAELAKVRAEMEVLL----ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1793
Query: 612 QTMEPKQRPAAGAPPELHSLRTQ----LRERDVRI---RHLEMDFEKSRSQREQEEKLLI 664
E +R A + R + L E+ I L+ + E + ++E E + L
Sbjct: 1794 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLR 1853
Query: 665 SAWYNMGMALQQRAGEERAPAH---AQSFLAQQRLATNS 700
+ A Q+R EE+A H + LAQ R A++S
Sbjct: 1854 RLAED--EAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1890
Score = 88.6 bits (218), Expect = 2e-17
Identities = 134/541 (24%), Positives = 226/541 (41%), Gaps = 71/541 (13%)
Query: 180 LSEEAEEGDE----LQQRCLDLERQLMLLSEEKQSLAQENAGLRERM---------GRPE 226
L E E+G++ L++ L+R+ ++++Q L E A +R M E
Sbjct: 1704 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1763
Query: 227 GEGTPGLTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAE---LQHRNQAL 283
T + ++L + +L EE RL + E+ A+ +R++AE + R +A
Sbjct: 1764 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE-----AKRQRQLAEEDAARQRAEAE 1818
Query: 284 TSLAQEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHA- 342
LA++ A+ E L+ +E A + + RRL E +R R+LEE+ A H
Sbjct: 1819 RVLAEKLAAI-GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR--RRLEEQAAQHKA 1875
Query: 343 ---ERTRQL----EDELRRAGSLRAQLEAQRRQVQE----LQGQRQEEAMKAEKWLFECR 391
ER QL + EL R L QRRQV+E L+ ++ A + E
Sbjct: 1876 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1935
Query: 392 NLEEKYESVTKEKER--LLAERDSLREANEELRCAQLQPR------GLTQADPSLDPTST 443
+ E + KE+ L A R A EE R + + R +A
Sbjct: 1936 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 1995
Query: 444 PVDNLAAEILPAELRETLLRLQLENKRLCR--QEAADRERQEELQRHLEDANRARHGLET 501
V+ L A++ E R R + E+ R + QEAA + Q E + H + L+
Sbjct: 1996 EVERLKAKV--EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2053
Query: 502 QHRLNQQQLSELRAQVEDLQKALQE-QGGKTEDAISILLKRKLEEHLQKLHEADLELQRK 560
+ Q L +LR + E ++A +E + + + R+ E ++L ++ E +
Sbjct: 2054 TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2113
Query: 561 REY----IEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEP 616
R E+L + ARR + Q L++K A A E+++++ + QT+
Sbjct: 2114 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA-ADAEMEKHKKFAE------QTLRQ 2166
Query: 617 KQRPAAGAPPELHSLRTQLRER-------DVRIRHLEMDFEKSRSQREQEEKLLISAWYN 669
K A EL +LR QL E D ++ L+ + ++ QR Q E+ L S
Sbjct: 2167 K----AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2222
Query: 670 M 670
M
Sbjct: 2223 M 2223
Score = 83.6 bits (205), Expect = 6e-16
Identities = 143/554 (25%), Positives = 223/554 (40%), Gaps = 76/554 (13%)
Query: 188 DELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQSQLEQ 247
+EL+ + + ER+L E+ Q +R E + A+K L+
Sbjct: 1525 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE---RS 1581
Query: 248 LQEENFRLESGREDERLRC---AELEREVAELQHRNQALTSLAQEAQALKDEMDELRQ-- 302
LQEE+ + RE+ R AE ER E + + A EA L+ + +E+ Q
Sbjct: 1582 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1641
Query: 303 ---SSERAGQLEATLTSCRRRLGELRELRRQVRQLEERN--------AGHAERTRQLEDE 351
+E Q E RRR G+ E + R+L E+ G A++ E E
Sbjct: 1642 SLAQAEAEKQKEEAEREARRR-GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1700
Query: 352 LRRAGSLRAQLEAQRRQVQELQGQRQEEA----------------MKAEKWLF---ECRN 392
L R + Q E QR+ ++E + Q EA ++AE + + R
Sbjct: 1701 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1760
Query: 393 LEEKYESVTKEKERLLAERDSLREANEE---LRC-AQLQPRGLTQADPSLDPTSTPVDNL 448
EE + K K+RL AE RE EE LR A+ R A+ + +
Sbjct: 1761 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1820
Query: 449 AAEILPAELRETLLRLQLENKRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQ 508
AE L A T RL+ E + +++ A+ ER L+R ED R LE Q ++
Sbjct: 1821 LAEKLAAIGEAT--RLKTEAEIALKEKEAENER---LRRLAEDEAFQRRRLEEQAAQHKA 1875
Query: 509 QLSELRAQVEDLQKA-LQEQGGKTEDAIS---------ILLKRKLEEHLQKLHEADLELQ 558
+ E AQ+ + L+ Q G ED + + LK E+ E +LEL
Sbjct: 1876 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1935
Query: 559 RKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYV-DKARMVMQTMEPK 617
R R E D+ ++ EL+ Q++ L A EER RR ++ + + E
Sbjct: 1936 RIRSNAE------DTLRSKEQAELEAARQRQ---LAAEEERRRREAEERVQKSLAAEEEA 1986
Query: 618 QRPAAGAPPELHSLRT------QLRER--DVRIRHLEMDFEKSRSQREQEEKLLISAWYN 669
R A E+ L+ +LRER R L++ E ++ + + EEK A
Sbjct: 1987 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2046
Query: 670 MGMALQQRAGEERA 683
LQQ +E++
Sbjct: 2047 KEQELQQTLQQEQS 2060
Score = 80.9 bits (198), Expect = 4e-15
Identities = 143/623 (22%), Positives = 255/623 (40%), Gaps = 97/623 (15%)
Query: 133 QRIMTLEESVQHVVMEAIQELM-TKDTPDSLSPETYGNFDSQSRRYYFLSEEAEEGD--- 188
+R+ E++ V + QEL T S+ + G ++ R +EEAEE
Sbjct: 2031 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA----AEEAEEARVQA 2086
Query: 189 -----ELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQS 243
+ +++ + ER E+ Q+ AQ A + E E A++ L Q
Sbjct: 2087 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2146
Query: 244 QL--------EQLQEENFRLESGREDE----RLRCAELEREV----AELQHRNQALTSLA 287
Q ++ E+ R ++ E E RL+ E + + ELQ T A
Sbjct: 2147 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAA 2206
Query: 288 QEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQ 347
++ +++E+ +R E +L+A + + R L LR+ R L+E AE+ +Q
Sbjct: 2207 RQRSQVEEELFSVRVQMEELSKLKARIEAENRAL-ILRDKDNTQRFLQEE----AEKMKQ 2261
Query: 348 LEDELRRAGSLRAQLEAQRRQVQE------------LQGQRQEEAMKAEKWLFECRNLEE 395
+ +E R S+ AQ A+ RQ+ E + ++ + +A + E L++
Sbjct: 2262 VAEEAARL-SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2320
Query: 396 KYESVTKEKERLLAERDSL-REANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILP 454
+ E ++ RL +++ + ++ EE + Q Q + + + AE+
Sbjct: 2321 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2380
Query: 455 AELRET----LLRLQLEN--KRLCRQEAADRERQE-----ELQRHLED--ANRARHG--- 498
A+ R R Q E ++L R E A +E+ E+QR D A R R
Sbjct: 2381 AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2440
Query: 499 LETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDAISILLKRKLEEHLQKLHEADLELQ 558
LE + QQ+ L+ + E++Q QEQ LL+ L E D LQ
Sbjct: 2441 LEREKEKLQQEAKLLQLKSEEMQTVQQEQ----------LLQETQALQQSFLSEKDSLLQ 2490
Query: 559 RKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQ 618
R+R +IE+ ++E+L + K LR ++R ++ +++ R Q
Sbjct: 2491 RER-FIEQ--------EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQER---------Q 2532
Query: 619 RPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRA 678
R A + R + E + +R + + ++ QR Q+E+LL + LQ
Sbjct: 2533 RLVA----SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2588
Query: 679 GEERAP-AHAQSFLAQQRLATNS 700
+ RA AH++ A Q AT +
Sbjct: 2589 EQHRAALAHSEEVTASQVAATKT 2611
Score = 80.1 bits (196), Expect = 7e-15
Identities = 115/545 (21%), Positives = 226/545 (41%), Gaps = 44/545 (8%)
Query: 183 EAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQ 242
+ E E QR + ++ + + +A+ +A + + PE +L L
Sbjct: 998 DKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTL 1057
Query: 243 SQLEQLQEENFRLESGREDERLRCAELE-REVAELQHRNQALTSLAQEAQALKDEMDELR 301
+LEQ+ R S E+L+ L R + +A +EAQA+ + EL
Sbjct: 1058 GKLEQV-----RSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELE 1112
Query: 302 QSSERAGQLEATLTSCRRRLGELRELRRQVRQLEER-NAGHAERTRQLE-------DELR 353
+ +L A + + LR+ R +++ ER H ER ++E L
Sbjct: 1113 ATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLE 1172
Query: 354 RAGSLRAQLEAQRRQVQELQGQ---RQEEAMKAEKWLFECRNLEEKYESV-----TKEKE 405
R ++ AQ + ++R++++L Q +E A WL + R +E+ +++ +E
Sbjct: 1173 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1232
Query: 406 RLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQ 465
+L E+ L E + R Q ++ + A++ P ++Q
Sbjct: 1233 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQ 1292
Query: 466 LENKRLCRQEAADRERQEEL----QRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQ 521
++ + ++ R EL ++++ + +E + RL +QQ +E R ++ +++
Sbjct: 1293 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1352
Query: 522 KALQEQGGKTE---------DAISILLKRKLEEHLQKLHEADLEL-QRKREYIEELEPPT 571
AL++Q E + + L+++++E + + EA ++ Q+KR EEL+
Sbjct: 1353 AALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR 1412
Query: 572 DSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSL 631
SS A +Q K A E R ++ R+V +E +R GA EL +L
Sbjct: 1413 QSSEA--------EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1464
Query: 632 RTQLRERDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFL 691
R + E + + R + + E+ R Q + E + A + ++ A R A L
Sbjct: 1465 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL 1524
Query: 692 AQQRL 696
+ RL
Sbjct: 1525 EELRL 1529
Score = 79.0 bits (193), Expect = 1e-14
Identities = 144/643 (22%), Positives = 255/643 (39%), Gaps = 85/643 (13%)
Query: 126 EKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYFLSEEAE 185
E D Q+ +++E +Q + + E+ K + + + + R E E
Sbjct: 1392 EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE 1451
Query: 186 ------EGD--ELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKK 237
EG+ L+ R + E Q EE + L ++ +R + E E + A+
Sbjct: 1452 RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEA 1511
Query: 238 LLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEM 297
+ Q E RL++ + RLR AE+ER Q +L ++ + E+
Sbjct: 1512 EAAREKQRALQALEELRLQAEEAERRLRQAEVER-------ARQVQVALETAQRSAEAEL 1564
Query: 298 DELRQS-SERAGQLEATLTSCRRRLGELR-ELRRQVRQLEERNAGHAERTRQLED-ELRR 354
R S +E+ QLE +L + +LR E R+ +Q E E R+LE +L+
Sbjct: 1565 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1624
Query: 355 AGSLRAQLE----AQRRQVQELQGQRQEEAM--------KAEKWLFECRNLEEKYESVTK 402
+LR +L+ AQ++ + + + ++Q+E KAE+ R L E+
Sbjct: 1625 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ----EL 1680
Query: 403 EKERLLAERDSLREANEELRCAQL--------QPRGLTQADPSLDPTSTPVDNLAAEILP 454
EK+R LAE + + E +L Q R L + + + + L
Sbjct: 1681 EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1740
Query: 455 AELRETLLRLQLENKRLCRQEAADRERQEELQRHLE-DANRARHGLETQHRL-------- 505
AEL + +++ R E R E+ ++ LE +A R R E RL
Sbjct: 1741 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1800
Query: 506 NQQQLSELRA--QVEDLQKALQEQGG--------KTEDAISILLKRKLEEHLQKLHEADL 555
Q+QL+E A Q + ++ L E+ KTE I++ K E L++L E D
Sbjct: 1801 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE-DE 1859
Query: 556 ELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTME 615
QR+R +EE + R+ +L+ + D++L ER + V+ + +E
Sbjct: 1860 AFQRRR--LEEQAAQHKADIEERLAQLR---KASDSEL----ERQKGLVEDTLRQRRQVE 1910
Query: 616 PKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQRE----QEEKLLISAWYNMG 671
E+ +L+ + LE++ + RS E +E+ + A
Sbjct: 1911 ----------EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ 1960
Query: 672 MALQQRAGEERAPAHAQSFLAQQRLATNSRRGPLGRLASLNLR 714
+A ++ A Q LA + A R+ L + L +
Sbjct: 1961 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2003
Score = 70.9 bits (172), Expect = 4e-12
Identities = 114/468 (24%), Positives = 195/468 (41%), Gaps = 62/468 (13%)
Query: 181 SEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLL 240
+E A + ++++ + Q+ LS+ K + EN L R T + L
Sbjct: 2203 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR--------DKDNTQRFLQE 2254
Query: 241 LQSQLEQLQEENFRLE-SGREDERLRCAELE-----REVAE--LQHRNQALTSLAQEAQA 292
+++Q+ EE RL + +E RLR E R +AE L+ + QA+ QEA
Sbjct: 2255 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAV----QEATR 2310
Query: 293 LKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDEL 352
LK E + L+Q E A + RRL E +E + +QL E G R LE E
Sbjct: 2311 LKAEAELLQQQKELAQEQA-------RRLQEDKE--QMAQQLAEETQGFQ---RTLEAER 2358
Query: 353 RRAGSLRAQLEAQRRQVQEL---QGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLA 409
+R + A+ E + +V E+ Q + +E+A + K E + E T+EK L+
Sbjct: 2359 QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2418
Query: 410 ERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENK 469
+ R+ Q+D + + L E + LL+L+ E
Sbjct: 2419 TLEIQRQ----------------QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2462
Query: 470 RLCRQEAADRERQEELQRHLEDAN---RARHGLETQHRLNQQQLSELRAQVEDLQKALQE 526
+ +QE +E Q Q L + + + +E + +Q + A+ + L++ Q
Sbjct: 2463 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2522
Query: 527 QGGKTEDAISILLKRKLEEHLQKLHEADLELQRKREYIEELEPPT---DSSTARRIEELQ 583
Q + E L+ +EE ++ HEA+ ++RK+E +++LE + A + L+
Sbjct: 2523 QQQQMEQERQRLVA-SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2581
Query: 584 HNLQKKDADLRAM----EERYRRYVDKARMVMQTMEPKQRPAAGAPPE 627
LQ + RA EE V + + + PAA A PE
Sbjct: 2582 EQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2629
Score = 54.3 bits (129), Expect = 4e-07
Identities = 100/471 (21%), Positives = 180/471 (38%), Gaps = 97/471 (20%)
Query: 299 ELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERN-------------------- 338
+L QS E+ Q E+ C+R + EL+++R Q+ E R
Sbjct: 953 QLLQSLEQGAQEESR---CQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRI 1009
Query: 339 --------------------AGHAERTRQLEDELRRAGSLRAQLEAQRRQVQELQG---- 374
+ AE+ L + A +LR++LE ++++++
Sbjct: 1010 AEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1069
Query: 375 ---------------QRQEEAMKA-EKWLFECR-------NLEEKYESVTKEKERLLAER 411
Q EE ++A E+ L E + LE S+ K + + A++
Sbjct: 1070 YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQ 1129
Query: 412 DSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEIL---PAELRETLLRLQLEN 468
+ +ELR AQ L Q D A++L A L +T +R Q E
Sbjct: 1130 PTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVR-QREL 1188
Query: 469 KRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQG 528
++L RQ RE + L L+DA R + ++ + Q + E Q + L + ++ G
Sbjct: 1189 EQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHG 1248
Query: 529 GKTEDAISILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQK 588
K E+ +R ++++ + + +L+L Y +LEP + +++ ++ +
Sbjct: 1249 EKVEEC-----QRFAKQYINAIKDYELQLV---TYKAQLEPVASPAKKPKVQSGSESVIQ 1300
Query: 589 KDADLRA----MEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRH 644
+ DLR + +Y+ ++ ME ++R A Q E R+
Sbjct: 1301 EYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLA----------EQQRAEERERLAE 1350
Query: 645 LEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQR 695
+E EK R E + A LQQR EE + AQQ+
Sbjct: 1351 VEAALEKQRQLAEAHAQAKAQA-EREAKELQQRMQEEVVRREEAAVDAQQQ 1400
Score = 49.3 bits (116), Expect = 1e-05
Identities = 87/378 (23%), Positives = 152/378 (40%), Gaps = 90/378 (23%)
Query: 162 LSPETYG---NFDSQSRRYYFLSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGL 218
L+ ET G +++ +R +S EAE L+ R ++ R E+ Q ++ +
Sbjct: 2343 LAEETQGFQRTLEAERQRQLEMSAEAER---LKLRVAEMSRAQARAEEDAQRFRKQAEEI 2399
Query: 219 RERMGRPEGEGTPGLTAKKLLLLQSQLEQLQEENFRLESGREDERLR--CAELEREVAEL 276
E++ R E T +K+ L+Q+ Q Q+ S + ERLR AELERE +L
Sbjct: 2400 GEKLHRTELA-----TQEKVTLVQTLEIQRQQ------SDHDAERLREAIAELEREKEKL 2448
Query: 277 QHRNQALT------------SLAQEAQALK-----------------------------D 295
Q + L L QE QAL+ D
Sbjct: 2449 QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2508
Query: 296 EMDELRQSSERAGQLEATLTSCRRRL-GELRELRRQVRQLEERNAGHAERTRQLEDELRR 354
E+ + +Q E + + + R+RL + E RR+ + E E R+ ++EL+
Sbjct: 2509 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE-------EGVRRKQEELQ- 2560
Query: 355 AGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSL 414
QLE QRRQ +EL + + + + + LEE++ + E + A + +
Sbjct: 2561 ------QLEQQRRQQEELLAEENQRLRE------QLQLLEEQHRAALAHSEEVTASQVAA 2608
Query: 415 REANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQ 474
+ R A P + + S D L ++ L+E + E +RL +
Sbjct: 2609 TKTLPNGRDALDGPAAEAEPEHSF-------DGLRRKVSAQRLQEAGILSAEELQRLAQG 2661
Query: 475 EAADRE--RQEELQRHLE 490
E R+E+++ +L+
Sbjct: 2662 HTTVDELARREDVRHYLQ 2679
Score = 33.1 bits (74), Expect = 0.92
Identities = 105/481 (21%), Positives = 182/481 (37%), Gaps = 60/481 (12%)
Query: 177 YYFLSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAK 236
Y+ L E E G +L L+ E+QL E + L + L+ G
Sbjct: 347 YHPLDVEKEWG-KLHVAILEREKQLRSEFERLECLQRIVTKLQMEAG------------- 392
Query: 237 KLLLLQSQLEQ----LQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQA 292
L + QL Q LQ + L +G+ +R E+ER+ L + + L + Q
Sbjct: 393 ---LCEEQLNQADALLQSDVRLLAAGKVPQR--AGEVERD---LDKADSMIRLLFNDVQT 444
Query: 293 LKD-EMDELRQSSERAGQLEATLTSCRRR--LGELRELRRQVRQLEERNAGHAERTRQLE 349
LKD + Q R +L L + R L + Q+ + +R +LE
Sbjct: 445 LKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELE 504
Query: 350 DE-LRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLL 408
D LR L A +E + +V + +++A+ L R L + E + ER
Sbjct: 505 DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQ--LGSHRGLHQSIEEFRAKIERAR 562
Query: 409 AERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAA--EILPAELRETLLRLQL 466
++ L A L L A L+ + + +L + + A +E + +
Sbjct: 563 SDEGQLSPATRGAYRDCLGRLDLQYAK-LLNSSKARLRSLESLHSFVAAATKELMWLNEK 621
Query: 467 ENKRLC-------RQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVED 519
E + + A +E L R LE + L+ ++ R VE
Sbjct: 622 EEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVES 681
Query: 520 LQKALQEQGGKTEDAISILLKRKLEEHLQK----------LHEADLELQRKREYIEELEP 569
Q ALQ T+ + + L +E HL++ + EA+ +LQ+ +E +
Sbjct: 682 FQAALQ-----TQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYS 736
Query: 570 PTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQ--RPAAGAPPE 627
S+T R+E+L + Q + L + +A+ V+Q ++P+ P G P
Sbjct: 737 CDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQ-LKPRHPAHPMRGRLPL 795
Query: 628 L 628
L
Sbjct: 796 L 796
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 95.9 bits (237), Expect = 1e-19
Identities = 131/536 (24%), Positives = 229/536 (42%), Gaps = 94/536 (17%)
Query: 233 LTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELE---------------------R 271
LT++ + + L +++EE E R +ER R AE+E R
Sbjct: 1356 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1415
Query: 272 EVAELQHRNQ--------ALTSLAQEAQALKDEMDELRQSSE-----RAGQLEATLTSCR 318
E ELQ R Q A Q+ +++++E+ +LRQSSE +A Q EA S
Sbjct: 1416 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL 1475
Query: 319 RRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRAQLEAQRRQVQE----LQG 374
R E+R +R Q+ E + G E EL+ + + EAQ+RQ QE L+
Sbjct: 1476 RIEEEIRVVRLQLEATERQRGG-------AEGELQALRARAEEAEAQKRQAQEEAERLRR 1528
Query: 375 QRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLR----EANEELRCAQLQPRG 430
Q Q+E+ + + E + + +EK+R L + LR EA LR A+++
Sbjct: 1529 QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1588
Query: 431 LTQ---------ADPSLDPTSTPVDNLAAEILPAELRE---TLLRLQLENKRLCRQEAAD 478
Q A+ L A+ L L+E + +L+ E +R +Q+A
Sbjct: 1589 QVQVALETAQRSAEAELQSKRASFAEKTAQ-LERSLQEEHVAVAQLREEAERRAQQQAEA 1647
Query: 479 RERQEELQRHLE----DANRA-RHGLETQHRLNQQQLSELRA--QVEDLQKALQEQGGKT 531
+EE +R LE AN A R L+ + Q+ L++ A Q E+ ++ + +G
Sbjct: 1648 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1707
Query: 532 EDAI--------SILLKRKL-----------EEHLQKLHEADLELQRKREYIEE----LE 568
E A+ + +R+L E+ L +L + +++R+ +EE L+
Sbjct: 1708 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1767
Query: 569 PPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPEL 628
++T +R +EL+ L K A++ + R +++R + + + AG EL
Sbjct: 1768 REAAAATQKR-QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1826
Query: 629 HSLRTQLRE-RDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERA 683
+LR + R ++ E + QR + E++L +G A + + E A
Sbjct: 1827 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1882
Score = 90.5 bits (223), Expect = 5e-18
Identities = 155/579 (26%), Positives = 245/579 (42%), Gaps = 88/579 (15%)
Query: 182 EEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTA-----K 236
+ AEE + L + LE+Q L Q+ AQ +E R + E A +
Sbjct: 1381 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ 1440
Query: 237 KLLLLQSQLEQL-------------QEENFRLESGREDERLRCAELEREVAELQHRN--- 280
+ +Q +L+QL Q E R +E +R L+ E E Q
Sbjct: 1441 QKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1500
Query: 281 --QALTSLAQEAQALK----DEMDELRQ----SSERAGQLEATLTSCRRRLGE-LRELRR 329
QAL + A+EA+A K +E + LR+ S+R Q E L S + E RE +R
Sbjct: 1501 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1560
Query: 330 QVRQLEERNAGHAERTRQL-EDELRRAGSLRAQLE-AQRRQVQELQGQRQEEAMKAEKWL 387
++ LEE E R+L + E+ RA ++ LE AQR ELQ +R A AEK
Sbjct: 1561 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR---ASFAEKTA 1617
Query: 388 FECRNLEEKYESVTKEKERLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDN 447
R+L+E++ +V + +E AER + ++A E R +A+ L+ +
Sbjct: 1618 QLERSLQEEHVAVAQLREE--AERRAQQQAEAE--------RAREEAERELERWQLKANE 1667
Query: 448 LAAEILPAE---LRETLLRLQLENKRLCRQEAADRE------------RQEEL-QRHLED 491
L AE +++L + + E ++ E A+RE RQ EL ++ LE
Sbjct: 1668 ALRLRLQAEEVAQQKSLAQAEAEKQK----EEAEREARRRGKAEEQAVRQRELAEQELEK 1723
Query: 492 ANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDAISILLKRKLEEHLQKLH 551
+ G Q +Q+L LRA+ E EQ + + L+R+ QK
Sbjct: 1724 QRQLAEGTAQQRLAAEQELIRLRAETEQ-----GEQQRQLLEEELARLQREAAAATQKRQ 1778
Query: 552 EADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVM 611
E + EL + R +E L +S AR EE + +K L A R+R ++A +
Sbjct: 1779 ELEAELAKVRAEMEVLL----ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1834
Query: 612 QTMEPKQRPAAGAPPELHSLRTQ----LRERDVRI---RHLEMDFEKSRSQREQEEKLLI 664
E +R A + R + L E+ I L+ + E + ++E E + L
Sbjct: 1835 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLR 1894
Query: 665 SAWYNMGMALQQRAGEERAPAH---AQSFLAQQRLATNS 700
+ A Q+R EE+A H + LAQ R A++S
Sbjct: 1895 RLAED--EAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1931
Score = 88.6 bits (218), Expect = 2e-17
Identities = 134/541 (24%), Positives = 226/541 (41%), Gaps = 71/541 (13%)
Query: 180 LSEEAEEGDE----LQQRCLDLERQLMLLSEEKQSLAQENAGLRERM---------GRPE 226
L E E+G++ L++ L+R+ ++++Q L E A +R M E
Sbjct: 1745 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1804
Query: 227 GEGTPGLTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAE---LQHRNQAL 283
T + ++L + +L EE RL + E+ A+ +R++AE + R +A
Sbjct: 1805 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE-----AKRQRQLAEEDAARQRAEAE 1859
Query: 284 TSLAQEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHA- 342
LA++ A+ E L+ +E A + + RRL E +R R+LEE+ A H
Sbjct: 1860 RVLAEKLAAI-GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR--RRLEEQAAQHKA 1916
Query: 343 ---ERTRQL----EDELRRAGSLRAQLEAQRRQVQE----LQGQRQEEAMKAEKWLFECR 391
ER QL + EL R L QRRQV+E L+ ++ A + E
Sbjct: 1917 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1976
Query: 392 NLEEKYESVTKEKER--LLAERDSLREANEELRCAQLQPR------GLTQADPSLDPTST 443
+ E + KE+ L A R A EE R + + R +A
Sbjct: 1977 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2036
Query: 444 PVDNLAAEILPAELRETLLRLQLENKRLCR--QEAADRERQEELQRHLEDANRARHGLET 501
V+ L A++ E R R + E+ R + QEAA + Q E + H + L+
Sbjct: 2037 EVERLKAKV--EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2094
Query: 502 QHRLNQQQLSELRAQVEDLQKALQE-QGGKTEDAISILLKRKLEEHLQKLHEADLELQRK 560
+ Q L +LR + E ++A +E + + + R+ E ++L ++ E +
Sbjct: 2095 TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2154
Query: 561 REY----IEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEP 616
R E+L + ARR + Q L++K A A E+++++ + QT+
Sbjct: 2155 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA-ADAEMEKHKKFAE------QTLRQ 2207
Query: 617 KQRPAAGAPPELHSLRTQLRER-------DVRIRHLEMDFEKSRSQREQEEKLLISAWYN 669
K A EL +LR QL E D ++ L+ + ++ QR Q E+ L S
Sbjct: 2208 K----AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2263
Query: 670 M 670
M
Sbjct: 2264 M 2264
Score = 83.6 bits (205), Expect = 6e-16
Identities = 143/554 (25%), Positives = 223/554 (40%), Gaps = 76/554 (13%)
Query: 188 DELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQSQLEQ 247
+EL+ + + ER+L E+ Q +R E + A+K L+
Sbjct: 1566 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE---RS 1622
Query: 248 LQEENFRLESGREDERLRC---AELEREVAELQHRNQALTSLAQEAQALKDEMDELRQ-- 302
LQEE+ + RE+ R AE ER E + + A EA L+ + +E+ Q
Sbjct: 1623 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1682
Query: 303 ---SSERAGQLEATLTSCRRRLGELRELRRQVRQLEERN--------AGHAERTRQLEDE 351
+E Q E RRR G+ E + R+L E+ G A++ E E
Sbjct: 1683 SLAQAEAEKQKEEAEREARRR-GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1741
Query: 352 LRRAGSLRAQLEAQRRQVQELQGQRQEEA----------------MKAEKWLF---ECRN 392
L R + Q E QR+ ++E + Q EA ++AE + + R
Sbjct: 1742 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1801
Query: 393 LEEKYESVTKEKERLLAERDSLREANEE---LRC-AQLQPRGLTQADPSLDPTSTPVDNL 448
EE + K K+RL AE RE EE LR A+ R A+ + +
Sbjct: 1802 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1861
Query: 449 AAEILPAELRETLLRLQLENKRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQ 508
AE L A T RL+ E + +++ A+ ER L+R ED R LE Q ++
Sbjct: 1862 LAEKLAAIGEAT--RLKTEAEIALKEKEAENER---LRRLAEDEAFQRRRLEEQAAQHKA 1916
Query: 509 QLSELRAQVEDLQKA-LQEQGGKTEDAIS---------ILLKRKLEEHLQKLHEADLELQ 558
+ E AQ+ + L+ Q G ED + + LK E+ E +LEL
Sbjct: 1917 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1976
Query: 559 RKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYV-DKARMVMQTMEPK 617
R R E D+ ++ EL+ Q++ L A EER RR ++ + + E
Sbjct: 1977 RIRSNAE------DTLRSKEQAELEAARQRQ---LAAEEERRRREAEERVQKSLAAEEEA 2027
Query: 618 QRPAAGAPPELHSLRT------QLRER--DVRIRHLEMDFEKSRSQREQEEKLLISAWYN 669
R A E+ L+ +LRER R L++ E ++ + + EEK A
Sbjct: 2028 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2087
Query: 670 MGMALQQRAGEERA 683
LQQ +E++
Sbjct: 2088 KEQELQQTLQQEQS 2101
Score = 80.9 bits (198), Expect = 4e-15
Identities = 143/623 (22%), Positives = 255/623 (40%), Gaps = 97/623 (15%)
Query: 133 QRIMTLEESVQHVVMEAIQELM-TKDTPDSLSPETYGNFDSQSRRYYFLSEEAEEGD--- 188
+R+ E++ V + QEL T S+ + G ++ R +EEAEE
Sbjct: 2072 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA----AEEAEEARVQA 2127
Query: 189 -----ELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQS 243
+ +++ + ER E+ Q+ AQ A + E E A++ L Q
Sbjct: 2128 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2187
Query: 244 QL--------EQLQEENFRLESGREDE----RLRCAELEREV----AELQHRNQALTSLA 287
Q ++ E+ R ++ E E RL+ E + + ELQ T A
Sbjct: 2188 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAA 2247
Query: 288 QEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQ 347
++ +++E+ +R E +L+A + + R L LR+ R L+E AE+ +Q
Sbjct: 2248 RQRSQVEEELFSVRVQMEELSKLKARIEAENRAL-ILRDKDNTQRFLQEE----AEKMKQ 2302
Query: 348 LEDELRRAGSLRAQLEAQRRQVQE------------LQGQRQEEAMKAEKWLFECRNLEE 395
+ +E R S+ AQ A+ RQ+ E + ++ + +A + E L++
Sbjct: 2303 VAEEAARL-SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2361
Query: 396 KYESVTKEKERLLAERDSL-REANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILP 454
+ E ++ RL +++ + ++ EE + Q Q + + + AE+
Sbjct: 2362 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2421
Query: 455 AELRET----LLRLQLEN--KRLCRQEAADRERQE-----ELQRHLED--ANRARHG--- 498
A+ R R Q E ++L R E A +E+ E+QR D A R R
Sbjct: 2422 AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2481
Query: 499 LETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDAISILLKRKLEEHLQKLHEADLELQ 558
LE + QQ+ L+ + E++Q QEQ LL+ L E D LQ
Sbjct: 2482 LEREKEKLQQEAKLLQLKSEEMQTVQQEQ----------LLQETQALQQSFLSEKDSLLQ 2531
Query: 559 RKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQ 618
R+R +IE+ ++E+L + K LR ++R ++ +++ R Q
Sbjct: 2532 RER-FIEQ--------EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQER---------Q 2573
Query: 619 RPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRA 678
R A + R + E + +R + + ++ QR Q+E+LL + LQ
Sbjct: 2574 RLVA----SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2629
Query: 679 GEERAP-AHAQSFLAQQRLATNS 700
+ RA AH++ A Q AT +
Sbjct: 2630 EQHRAALAHSEEVTASQVAATKT 2652
Score = 80.1 bits (196), Expect = 7e-15
Identities = 115/545 (21%), Positives = 226/545 (41%), Gaps = 44/545 (8%)
Query: 183 EAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQ 242
+ E E QR + ++ + + +A+ +A + + PE +L L
Sbjct: 1039 DKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTL 1098
Query: 243 SQLEQLQEENFRLESGREDERLRCAELE-REVAELQHRNQALTSLAQEAQALKDEMDELR 301
+LEQ+ R S E+L+ L R + +A +EAQA+ + EL
Sbjct: 1099 GKLEQV-----RSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELE 1153
Query: 302 QSSERAGQLEATLTSCRRRLGELRELRRQVRQLEER-NAGHAERTRQLE-------DELR 353
+ +L A + + LR+ R +++ ER H ER ++E L
Sbjct: 1154 ATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLE 1213
Query: 354 RAGSLRAQLEAQRRQVQELQGQ---RQEEAMKAEKWLFECRNLEEKYESV-----TKEKE 405
R ++ AQ + ++R++++L Q +E A WL + R +E+ +++ +E
Sbjct: 1214 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1273
Query: 406 RLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQ 465
+L E+ L E + R Q ++ + A++ P ++Q
Sbjct: 1274 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQ 1333
Query: 466 LENKRLCRQEAADRERQEEL----QRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQ 521
++ + ++ R EL ++++ + +E + RL +QQ +E R ++ +++
Sbjct: 1334 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1393
Query: 522 KALQEQGGKTE---------DAISILLKRKLEEHLQKLHEADLEL-QRKREYIEELEPPT 571
AL++Q E + + L+++++E + + EA ++ Q+KR EEL+
Sbjct: 1394 AALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR 1453
Query: 572 DSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSL 631
SS A +Q K A E R ++ R+V +E +R GA EL +L
Sbjct: 1454 QSSEA--------EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1505
Query: 632 RTQLRERDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFL 691
R + E + + R + + E+ R Q + E + A + ++ A R A L
Sbjct: 1506 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL 1565
Query: 692 AQQRL 696
+ RL
Sbjct: 1566 EELRL 1570
Score = 79.0 bits (193), Expect = 1e-14
Identities = 144/643 (22%), Positives = 255/643 (39%), Gaps = 85/643 (13%)
Query: 126 EKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYFLSEEAE 185
E D Q+ +++E +Q + + E+ K + + + + R E E
Sbjct: 1433 EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE 1492
Query: 186 ------EGD--ELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKK 237
EG+ L+ R + E Q EE + L ++ +R + E E + A+
Sbjct: 1493 RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEA 1552
Query: 238 LLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEM 297
+ Q E RL++ + RLR AE+ER Q +L ++ + E+
Sbjct: 1553 EAAREKQRALQALEELRLQAEEAERRLRQAEVER-------ARQVQVALETAQRSAEAEL 1605
Query: 298 DELRQS-SERAGQLEATLTSCRRRLGELR-ELRRQVRQLEERNAGHAERTRQLED-ELRR 354
R S +E+ QLE +L + +LR E R+ +Q E E R+LE +L+
Sbjct: 1606 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1665
Query: 355 AGSLRAQLE----AQRRQVQELQGQRQEEAM--------KAEKWLFECRNLEEKYESVTK 402
+LR +L+ AQ++ + + + ++Q+E KAE+ R L E+
Sbjct: 1666 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ----EL 1721
Query: 403 EKERLLAERDSLREANEELRCAQL--------QPRGLTQADPSLDPTSTPVDNLAAEILP 454
EK+R LAE + + E +L Q R L + + + + L
Sbjct: 1722 EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1781
Query: 455 AELRETLLRLQLENKRLCRQEAADRERQEELQRHLE-DANRARHGLETQHRL-------- 505
AEL + +++ R E R E+ ++ LE +A R R E RL
Sbjct: 1782 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1841
Query: 506 NQQQLSELRA--QVEDLQKALQEQGG--------KTEDAISILLKRKLEEHLQKLHEADL 555
Q+QL+E A Q + ++ L E+ KTE I++ K E L++L E D
Sbjct: 1842 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE-DE 1900
Query: 556 ELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTME 615
QR+R +EE + R+ +L+ + D++L ER + V+ + +E
Sbjct: 1901 AFQRRR--LEEQAAQHKADIEERLAQLR---KASDSEL----ERQKGLVEDTLRQRRQVE 1951
Query: 616 PKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQRE----QEEKLLISAWYNMG 671
E+ +L+ + LE++ + RS E +E+ + A
Sbjct: 1952 ----------EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ 2001
Query: 672 MALQQRAGEERAPAHAQSFLAQQRLATNSRRGPLGRLASLNLR 714
+A ++ A Q LA + A R+ L + L +
Sbjct: 2002 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2044
Score = 70.9 bits (172), Expect = 4e-12
Identities = 114/468 (24%), Positives = 195/468 (41%), Gaps = 62/468 (13%)
Query: 181 SEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLL 240
+E A + ++++ + Q+ LS+ K + EN L R T + L
Sbjct: 2244 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR--------DKDNTQRFLQE 2295
Query: 241 LQSQLEQLQEENFRLE-SGREDERLRCAELE-----REVAE--LQHRNQALTSLAQEAQA 292
+++Q+ EE RL + +E RLR E R +AE L+ + QA+ QEA
Sbjct: 2296 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAV----QEATR 2351
Query: 293 LKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDEL 352
LK E + L+Q E A + RRL E +E + +QL E G R LE E
Sbjct: 2352 LKAEAELLQQQKELAQEQA-------RRLQEDKE--QMAQQLAEETQGFQ---RTLEAER 2399
Query: 353 RRAGSLRAQLEAQRRQVQEL---QGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLA 409
+R + A+ E + +V E+ Q + +E+A + K E + E T+EK L+
Sbjct: 2400 QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2459
Query: 410 ERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENK 469
+ R+ Q+D + + L E + LL+L+ E
Sbjct: 2460 TLEIQRQ----------------QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2503
Query: 470 RLCRQEAADRERQEELQRHLEDAN---RARHGLETQHRLNQQQLSELRAQVEDLQKALQE 526
+ +QE +E Q Q L + + + +E + +Q + A+ + L++ Q
Sbjct: 2504 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2563
Query: 527 QGGKTEDAISILLKRKLEEHLQKLHEADLELQRKREYIEELEPPT---DSSTARRIEELQ 583
Q + E L+ +EE ++ HEA+ ++RK+E +++LE + A + L+
Sbjct: 2564 QQQQMEQERQRLVA-SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2622
Query: 584 HNLQKKDADLRAM----EERYRRYVDKARMVMQTMEPKQRPAAGAPPE 627
LQ + RA EE V + + + PAA A PE
Sbjct: 2623 EQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2670
Score = 54.3 bits (129), Expect = 4e-07
Identities = 100/471 (21%), Positives = 180/471 (38%), Gaps = 97/471 (20%)
Query: 299 ELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERN-------------------- 338
+L QS E+ Q E+ C+R + EL+++R Q+ E R
Sbjct: 994 QLLQSLEQGAQEESR---CQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRI 1050
Query: 339 --------------------AGHAERTRQLEDELRRAGSLRAQLEAQRRQVQELQG---- 374
+ AE+ L + A +LR++LE ++++++
Sbjct: 1051 AEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1110
Query: 375 ---------------QRQEEAMKA-EKWLFECR-------NLEEKYESVTKEKERLLAER 411
Q EE ++A E+ L E + LE S+ K + + A++
Sbjct: 1111 YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQ 1170
Query: 412 DSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEIL---PAELRETLLRLQLEN 468
+ +ELR AQ L Q D A++L A L +T +R Q E
Sbjct: 1171 PTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVR-QREL 1229
Query: 469 KRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQG 528
++L RQ RE + L L+DA R + ++ + Q + E Q + L + ++ G
Sbjct: 1230 EQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHG 1289
Query: 529 GKTEDAISILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQK 588
K E+ +R ++++ + + +L+L Y +LEP + +++ ++ +
Sbjct: 1290 EKVEEC-----QRFAKQYINAIKDYELQLV---TYKAQLEPVASPAKKPKVQSGSESVIQ 1341
Query: 589 KDADLRA----MEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRH 644
+ DLR + +Y+ ++ ME ++R A Q E R+
Sbjct: 1342 EYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLA----------EQQRAEERERLAE 1391
Query: 645 LEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQR 695
+E EK R E + A LQQR EE + AQQ+
Sbjct: 1392 VEAALEKQRQLAEAHAQAKAQA-EREAKELQQRMQEEVVRREEAAVDAQQQ 1441
Score = 49.3 bits (116), Expect = 1e-05
Identities = 87/378 (23%), Positives = 152/378 (40%), Gaps = 90/378 (23%)
Query: 162 LSPETYG---NFDSQSRRYYFLSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGL 218
L+ ET G +++ +R +S EAE L+ R ++ R E+ Q ++ +
Sbjct: 2384 LAEETQGFQRTLEAERQRQLEMSAEAER---LKLRVAEMSRAQARAEEDAQRFRKQAEEI 2440
Query: 219 RERMGRPEGEGTPGLTAKKLLLLQSQLEQLQEENFRLESGREDERLR--CAELEREVAEL 276
E++ R E T +K+ L+Q+ Q Q+ S + ERLR AELERE +L
Sbjct: 2441 GEKLHRTELA-----TQEKVTLVQTLEIQRQQ------SDHDAERLREAIAELEREKEKL 2489
Query: 277 QHRNQALT------------SLAQEAQALK-----------------------------D 295
Q + L L QE QAL+ D
Sbjct: 2490 QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2549
Query: 296 EMDELRQSSERAGQLEATLTSCRRRL-GELRELRRQVRQLEERNAGHAERTRQLEDELRR 354
E+ + +Q E + + + R+RL + E RR+ + E E R+ ++EL+
Sbjct: 2550 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE-------EGVRRKQEELQ- 2601
Query: 355 AGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSL 414
QLE QRRQ +EL + + + + + LEE++ + E + A + +
Sbjct: 2602 ------QLEQQRRQQEELLAEENQRLRE------QLQLLEEQHRAALAHSEEVTASQVAA 2649
Query: 415 REANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQ 474
+ R A P + + S D L ++ L+E + E +RL +
Sbjct: 2650 TKTLPNGRDALDGPAAEAEPEHSF-------DGLRRKVSAQRLQEAGILSAEELQRLAQG 2702
Query: 475 EAADRE--RQEELQRHLE 490
E R+E+++ +L+
Sbjct: 2703 HTTVDELARREDVRHYLQ 2720
Score = 33.1 bits (74), Expect = 0.92
Identities = 105/481 (21%), Positives = 182/481 (37%), Gaps = 60/481 (12%)
Query: 177 YYFLSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAK 236
Y+ L E E G +L L+ E+QL E + L + L+ G
Sbjct: 388 YHPLDVEKEWG-KLHVAILEREKQLRSEFERLECLQRIVTKLQMEAG------------- 433
Query: 237 KLLLLQSQLEQ----LQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQA 292
L + QL Q LQ + L +G+ +R E+ER+ L + + L + Q
Sbjct: 434 ---LCEEQLNQADALLQSDVRLLAAGKVPQR--AGEVERD---LDKADSMIRLLFNDVQT 485
Query: 293 LKD-EMDELRQSSERAGQLEATLTSCRRR--LGELRELRRQVRQLEERNAGHAERTRQLE 349
LKD + Q R +L L + R L + Q+ + +R +LE
Sbjct: 486 LKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELE 545
Query: 350 DE-LRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLL 408
D LR L A +E + +V + +++A+ L R L + E + ER
Sbjct: 546 DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQ--LGSHRGLHQSIEEFRAKIERAR 603
Query: 409 AERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAA--EILPAELRETLLRLQL 466
++ L A L L A L+ + + +L + + A +E + +
Sbjct: 604 SDEGQLSPATRGAYRDCLGRLDLQYAK-LLNSSKARLRSLESLHSFVAAATKELMWLNEK 662
Query: 467 ENKRLC-------RQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVED 519
E + + A +E L R LE + L+ ++ R VE
Sbjct: 663 EEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVES 722
Query: 520 LQKALQEQGGKTEDAISILLKRKLEEHLQK----------LHEADLELQRKREYIEELEP 569
Q ALQ T+ + + L +E HL++ + EA+ +LQ+ +E +
Sbjct: 723 FQAALQ-----TQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYS 777
Query: 570 PTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQ--RPAAGAPPE 627
S+T R+E+L + Q + L + +A+ V+Q ++P+ P G P
Sbjct: 778 CDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQ-LKPRHPAHPMRGRLPL 836
Query: 628 L 628
L
Sbjct: 837 L 837
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 95.1 bits (235), Expect = 2e-19
Identities = 129/537 (24%), Positives = 223/537 (41%), Gaps = 54/537 (10%)
Query: 180 LSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLL 239
LS + + Q+ + R + L +++ E AGLRE++ E ++L
Sbjct: 1335 LSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQL--EEEAAARERAGRELQ 1392
Query: 240 LLQSQLEQL----QEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKD 295
Q+QL + +EE LE+G E R E E L + + + L + + L+
Sbjct: 1393 TAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQ 1452
Query: 296 EMDELRQSSERAGQLEATLTSCRRRLGEL--RELRRQVRQLEERNAGHAE-RTRQLEDEL 352
E+D+ E+ QL +TL +R+ +L E +R +EER AE R R+
Sbjct: 1453 ELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGRERE----- 1507
Query: 353 RRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERD 412
RA SL LE ++ +EL +RQ A++A E E LL+ +D
Sbjct: 1508 ARALSLTRALEEEQEAREEL--ERQNRALRA-------------------ELEALLSSKD 1546
Query: 413 SLREANEELRCAQLQPRGLTQADPSLDPTSTPVDN--LAAEILPAELRETLLRLQLENKR 470
+ ++ EL A R QA L T +++ AAE L T+ L+ +++R
Sbjct: 1547 DVGKSVHELERA---CRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHER 1603
Query: 471 -LCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGG 529
L ++ A ER+ +L + L DA R Q L +L ++E+L+ + G
Sbjct: 1604 DLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQ 1663
Query: 530 KTEDAISILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKK 589
E+A+ L RK++ +++L E + RE I + + +R++ L+ + +
Sbjct: 1664 GKEEAVKQL--RKMQAQMKELWREVEETRTSREEIFS----QNRESEKRLKGLEAEVLRL 1717
Query: 590 DADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDF 649
+L A +R RR + R M A ++ + R+ + R+ LE +
Sbjct: 1718 QEEL-AASDRARRQAQQDRDEMAD------EVANGNLSKAAILEEKRQLEGRLGQLEEEL 1770
Query: 650 EKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQRLATNSRRGPLG 706
E+ +S E + + + E A A+S Q RG LG
Sbjct: 1771 EEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLG 1827
Score = 87.8 bits (216), Expect = 3e-17
Identities = 135/538 (25%), Positives = 220/538 (40%), Gaps = 84/538 (15%)
Query: 195 LDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQSQLEQLQEENFR 254
L + RQ +L Q L Q+ L+++ R GE LQ ++ QL+EE R
Sbjct: 870 LQVTRQDEVLQARAQEL-QKVQELQQQSAREVGE------------LQGRVAQLEEERAR 916
Query: 255 LESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDEL-RQSSERAGQLEAT 313
L E CAE E L R Q L + E +A E +E RQ +L+
Sbjct: 917 LAEQLRAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQH 976
Query: 314 LTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRAQLEAQRRQVQELQ 373
+ L E E RQ QLE+ + ++ E++L ++L +R+ +++
Sbjct: 977 IQELEAHL-EAEEGARQKLQLEKVTT--EAKMKKFEEDLLLLEDQNSKLSKERKLLEDRL 1033
Query: 374 GQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEELR------CAQLQ 427
+ +A + E+ + L KYE+ + E L + + R+ E+L+ ++LQ
Sbjct: 1034 AEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQ 1093
Query: 428 PRGLTQADPSLDPTSTPVDNLAAEI--LPAELRETLLRLQLENKRLCRQEAADRERQ--- 482
+ + Q + + L A++ EL+ L R + E + + RE Q
Sbjct: 1094 EQMVEQQQRA--------EELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAAL 1145
Query: 483 EELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDL---QKALQEQGGKTEDAISILL 539
E Q LE AR E Q R ++L LR ++ED A QE K E ++ L
Sbjct: 1146 AEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVT-EL 1204
Query: 540 KRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEER 599
K+ LEE ++HEA ++ R+R + + EL L++ A E
Sbjct: 1205 KKTLEEE-TRIHEAAVQELRQRH-------------GQALGELAEQLEQARRGKGAWE-- 1248
Query: 600 YRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEM----------DF 649
K R+ ++ + R EL SL+T +E + R R LE+ D
Sbjct: 1249 ------KTRLALEAEVSELR------AELSSLQTARQEGEQRRRRLELQLQEVQGRAGDG 1296
Query: 650 EKSRS------QREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQRLATNSR 701
E++R+ QR Q E +S N + R +E + AQ AQ+ L +R
Sbjct: 1297 ERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETR 1354
Score = 85.5 bits (210), Expect = 2e-16
Identities = 143/577 (24%), Positives = 243/577 (42%), Gaps = 57/577 (9%)
Query: 126 EKK--QDHIQRI---MTLEESV-QHVVMEAI--QELMTKDTPDSLSPETYGNFDSQSRRY 177
EKK Q HIQ + + EE Q + +E + + M K D L E + S+ R+
Sbjct: 969 EKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKL 1028
Query: 178 YF--LSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTA 235
L+E + + E +++ L + + L E E+ +E GR E E
Sbjct: 1029 LEDRLAEFSSQAAEEEEKVKSLNK--LRLKYEATIADMEDRLRKEEKGRQELEKLKRRLD 1086
Query: 236 KKLLLLQSQLEQLQE--ENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQAL 293
+ LQ Q+ + Q+ E R + GR++E L+ A L R E R Q L SL + AL
Sbjct: 1087 GESSELQEQMVEQQQRAEELRAQLGRKEEELQAA-LARAEDEGGARAQLLKSLREAQAAL 1145
Query: 294 KDEMDELRQSSERAGQLEATLTSCRRRLGE-LRELRRQVRQ-LEERNAGHAERTRQLEDE 351
+ ++L SER + +A RR LGE L LR ++ L+ NA R+++ ++
Sbjct: 1146 AEAQEDLE--SERVARTKAEKQ--RRDLGEELEALRGELEDTLDSTNAQQELRSKREQEV 1201
Query: 352 LRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYE----SVTKEKERL 407
+L + VQEL+ + + + + L + R + +E ++ E L
Sbjct: 1202 TELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSEL 1261
Query: 408 LAERDSLREANEE---------LRCAQLQ------PRGLTQADPSLDPTSTPVDNLAAEI 452
AE SL+ A +E L+ ++Q R +A L ++N++ +
Sbjct: 1262 RAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGAL 1321
Query: 453 LPAELRETLLRLQLENKRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSE 512
AE + L +K L EA + QE LQ + RA+ L ++ R + + +
Sbjct: 1322 NEAESKTIRL-----SKELSSTEAQLHDAQELLQ----EETRAKLALGSRVRAMEAEAAG 1372
Query: 513 LRAQVEDLQKALQEQGGKTEDAISIL--LKRKLEEHLQKLHEADLELQRKREYIEELEP- 569
LR Q+E+ A + G + + A + L +R+ EE L + +R E L
Sbjct: 1373 LREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQR 1432
Query: 570 -PTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVD----KARMVMQTMEPKQRPAAGA 624
+ T R+E + LQ++ D E+ R+ V K R Q + ++ A
Sbjct: 1433 LAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRA 1492
Query: 625 PPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEEK 661
E + RER+ R L E+ + RE+ E+
Sbjct: 1493 VEERERAEAEGREREARALSLTRALEEEQEAREELER 1529
Score = 54.3 bits (129), Expect = 4e-07
Identities = 73/322 (22%), Positives = 142/322 (44%), Gaps = 38/322 (11%)
Query: 112 GKLLQLVLGCAISCEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFD 171
G+L +L A + + K++ ++++ ++ ++ + E + +++ S + E+
Sbjct: 1649 GELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLK 1708
Query: 172 SQSRRYYFLSEEAEEGD----ELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEG 227
L EE D + QQ ++ ++ + K ++ +E L R+G+ E
Sbjct: 1709 GLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEE 1768
Query: 228 EGTPGLTAKKLL-----LLQSQLEQLQEE-------NFRLESGREDERLRCAELEREVAE 275
E + +LL L Q+E L E + + ESGR+ +LER++ E
Sbjct: 1769 ELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQ-------QLERQIQE 1821
Query: 276 LQHR--NQALTSLAQEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQ 333
L+ R + + A+ + +L Q+ E+ Q R R+ + +RR ++
Sbjct: 1822 LRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQ------ETRERILSGKLVRRAEKR 1875
Query: 334 LEERNAGHAERTRQLEDELRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNL 393
L+E Q+E+E R A LR QLE +V++L+ Q +E +A + R L
Sbjct: 1876 LKEV-------VLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRL 1928
Query: 394 EEKYESVTKEKERLLAERDSLR 415
+ + E VT+ E + E +LR
Sbjct: 1929 QRELEDVTESAESMNREVTTLR 1950
Score = 44.7 bits (104), Expect = 3e-04
Identities = 56/244 (22%), Positives = 104/244 (42%), Gaps = 14/244 (5%)
Query: 189 ELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLL-----LQS 243
E ++R LE +++ L EE + + ++ E G +K +L L+
Sbjct: 1702 ESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEG 1761
Query: 244 QLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDELRQS 303
+L QL+EE +S E R +L +V L A S + +A++ + +++ RQ
Sbjct: 1762 RLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLE--RQI 1819
Query: 304 SERAGQLEATLTSCR-RRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRA-- 360
E G+L R R + L ++ Q EE+ R R L +L R R
Sbjct: 1820 QELRGRLGEEDAGARARHKMTIAALESKLAQAEEQ-LEQETRERILSGKLVRRAEKRLKE 1878
Query: 361 ---QLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREA 417
Q+E +RR +L+ Q ++ ++ ++ + EE+ + RL E + + E+
Sbjct: 1879 VVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTES 1938
Query: 418 NEEL 421
E +
Sbjct: 1939 AESM 1942
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 95.1 bits (235), Expect = 2e-19
Identities = 129/537 (24%), Positives = 223/537 (41%), Gaps = 54/537 (10%)
Query: 180 LSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLL 239
LS + + Q+ + R + L +++ E AGLRE++ E ++L
Sbjct: 1327 LSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQL--EEEAAARERAGRELQ 1384
Query: 240 LLQSQLEQL----QEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKD 295
Q+QL + +EE LE+G E R E E L + + + L + + L+
Sbjct: 1385 TAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQ 1444
Query: 296 EMDELRQSSERAGQLEATLTSCRRRLGEL--RELRRQVRQLEERNAGHAE-RTRQLEDEL 352
E+D+ E+ QL +TL +R+ +L E +R +EER AE R R+
Sbjct: 1445 ELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGRERE----- 1499
Query: 353 RRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERD 412
RA SL LE ++ +EL +RQ A++A E E LL+ +D
Sbjct: 1500 ARALSLTRALEEEQEAREEL--ERQNRALRA-------------------ELEALLSSKD 1538
Query: 413 SLREANEELRCAQLQPRGLTQADPSLDPTSTPVDN--LAAEILPAELRETLLRLQLENKR 470
+ ++ EL A R QA L T +++ AAE L T+ L+ +++R
Sbjct: 1539 DVGKSVHELERA---CRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHER 1595
Query: 471 -LCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGG 529
L ++ A ER+ +L + L DA R Q L +L ++E+L+ + G
Sbjct: 1596 DLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQ 1655
Query: 530 KTEDAISILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKK 589
E+A+ L RK++ +++L E + RE I + + +R++ L+ + +
Sbjct: 1656 GKEEAVKQL--RKMQAQMKELWREVEETRTSREEIFS----QNRESEKRLKGLEAEVLRL 1709
Query: 590 DADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDF 649
+L A +R RR + R M A ++ + R+ + R+ LE +
Sbjct: 1710 QEEL-AASDRARRQAQQDRDEMAD------EVANGNLSKAAILEEKRQLEGRLGQLEEEL 1762
Query: 650 EKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQRLATNSRRGPLG 706
E+ +S E + + + E A A+S Q RG LG
Sbjct: 1763 EEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLG 1819
Score = 87.8 bits (216), Expect = 3e-17
Identities = 135/538 (25%), Positives = 220/538 (40%), Gaps = 84/538 (15%)
Query: 195 LDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQSQLEQLQEENFR 254
L + RQ +L Q L Q+ L+++ R GE LQ ++ QL+EE R
Sbjct: 862 LQVTRQDEVLQARAQEL-QKVQELQQQSAREVGE------------LQGRVAQLEEERAR 908
Query: 255 LESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDEL-RQSSERAGQLEAT 313
L E CAE E L R Q L + E +A E +E RQ +L+
Sbjct: 909 LAEQLRAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQH 968
Query: 314 LTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRAQLEAQRRQVQELQ 373
+ L E E RQ QLE+ + ++ E++L ++L +R+ +++
Sbjct: 969 IQELEAHL-EAEEGARQKLQLEKVTT--EAKMKKFEEDLLLLEDQNSKLSKERKLLEDRL 1025
Query: 374 GQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEELR------CAQLQ 427
+ +A + E+ + L KYE+ + E L + + R+ E+L+ ++LQ
Sbjct: 1026 AEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQ 1085
Query: 428 PRGLTQADPSLDPTSTPVDNLAAEI--LPAELRETLLRLQLENKRLCRQEAADRERQ--- 482
+ + Q + + L A++ EL+ L R + E + + RE Q
Sbjct: 1086 EQMVEQQQRA--------EELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAAL 1137
Query: 483 EELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDL---QKALQEQGGKTEDAISILL 539
E Q LE AR E Q R ++L LR ++ED A QE K E ++ L
Sbjct: 1138 AEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVT-EL 1196
Query: 540 KRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEER 599
K+ LEE ++HEA ++ R+R + + EL L++ A E
Sbjct: 1197 KKTLEEE-TRIHEAAVQELRQRH-------------GQALGELAEQLEQARRGKGAWE-- 1240
Query: 600 YRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEM----------DF 649
K R+ ++ + R EL SL+T +E + R R LE+ D
Sbjct: 1241 ------KTRLALEAEVSELR------AELSSLQTARQEGEQRRRRLELQLQEVQGRAGDG 1288
Query: 650 EKSRS------QREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQRLATNSR 701
E++R+ QR Q E +S N + R +E + AQ AQ+ L +R
Sbjct: 1289 ERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETR 1346
Score = 85.5 bits (210), Expect = 2e-16
Identities = 143/577 (24%), Positives = 243/577 (42%), Gaps = 57/577 (9%)
Query: 126 EKK--QDHIQRI---MTLEESV-QHVVMEAI--QELMTKDTPDSLSPETYGNFDSQSRRY 177
EKK Q HIQ + + EE Q + +E + + M K D L E + S+ R+
Sbjct: 961 EKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKL 1020
Query: 178 YF--LSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTA 235
L+E + + E +++ L + + L E E+ +E GR E E
Sbjct: 1021 LEDRLAEFSSQAAEEEEKVKSLNK--LRLKYEATIADMEDRLRKEEKGRQELEKLKRRLD 1078
Query: 236 KKLLLLQSQLEQLQE--ENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQAL 293
+ LQ Q+ + Q+ E R + GR++E L+ A L R E R Q L SL + AL
Sbjct: 1079 GESSELQEQMVEQQQRAEELRAQLGRKEEELQAA-LARAEDEGGARAQLLKSLREAQAAL 1137
Query: 294 KDEMDELRQSSERAGQLEATLTSCRRRLGE-LRELRRQVRQ-LEERNAGHAERTRQLEDE 351
+ ++L SER + +A RR LGE L LR ++ L+ NA R+++ ++
Sbjct: 1138 AEAQEDLE--SERVARTKAEKQ--RRDLGEELEALRGELEDTLDSTNAQQELRSKREQEV 1193
Query: 352 LRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYE----SVTKEKERL 407
+L + VQEL+ + + + + L + R + +E ++ E L
Sbjct: 1194 TELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSEL 1253
Query: 408 LAERDSLREANEE---------LRCAQLQ------PRGLTQADPSLDPTSTPVDNLAAEI 452
AE SL+ A +E L+ ++Q R +A L ++N++ +
Sbjct: 1254 RAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGAL 1313
Query: 453 LPAELRETLLRLQLENKRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSE 512
AE + L +K L EA + QE LQ + RA+ L ++ R + + +
Sbjct: 1314 NEAESKTIRL-----SKELSSTEAQLHDAQELLQ----EETRAKLALGSRVRAMEAEAAG 1364
Query: 513 LRAQVEDLQKALQEQGGKTEDAISIL--LKRKLEEHLQKLHEADLELQRKREYIEELEP- 569
LR Q+E+ A + G + + A + L +R+ EE L + +R E L
Sbjct: 1365 LREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQR 1424
Query: 570 -PTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVD----KARMVMQTMEPKQRPAAGA 624
+ T R+E + LQ++ D E+ R+ V K R Q + ++ A
Sbjct: 1425 LAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRA 1484
Query: 625 PPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEEK 661
E + RER+ R L E+ + RE+ E+
Sbjct: 1485 VEERERAEAEGREREARALSLTRALEEEQEAREELER 1521
Score = 54.3 bits (129), Expect = 4e-07
Identities = 73/322 (22%), Positives = 142/322 (44%), Gaps = 38/322 (11%)
Query: 112 GKLLQLVLGCAISCEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFD 171
G+L +L A + + K++ ++++ ++ ++ + E + +++ S + E+
Sbjct: 1641 GELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLK 1700
Query: 172 SQSRRYYFLSEEAEEGD----ELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEG 227
L EE D + QQ ++ ++ + K ++ +E L R+G+ E
Sbjct: 1701 GLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEE 1760
Query: 228 EGTPGLTAKKLL-----LLQSQLEQLQEE-------NFRLESGREDERLRCAELEREVAE 275
E + +LL L Q+E L E + + ESGR+ +LER++ E
Sbjct: 1761 ELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQ-------QLERQIQE 1813
Query: 276 LQHR--NQALTSLAQEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQ 333
L+ R + + A+ + +L Q+ E+ Q R R+ + +RR ++
Sbjct: 1814 LRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQ------ETRERILSGKLVRRAEKR 1867
Query: 334 LEERNAGHAERTRQLEDELRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNL 393
L+E Q+E+E R A LR QLE +V++L+ Q +E +A + R L
Sbjct: 1868 LKEV-------VLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRL 1920
Query: 394 EEKYESVTKEKERLLAERDSLR 415
+ + E VT+ E + E +LR
Sbjct: 1921 QRELEDVTESAESMNREVTTLR 1942
Score = 44.7 bits (104), Expect = 3e-04
Identities = 56/244 (22%), Positives = 104/244 (42%), Gaps = 14/244 (5%)
Query: 189 ELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLL-----LQS 243
E ++R LE +++ L EE + + ++ E G +K +L L+
Sbjct: 1694 ESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEG 1753
Query: 244 QLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDELRQS 303
+L QL+EE +S E R +L +V L A S + +A++ + +++ RQ
Sbjct: 1754 RLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLE--RQI 1811
Query: 304 SERAGQLEATLTSCR-RRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRA-- 360
E G+L R R + L ++ Q EE+ R R L +L R R
Sbjct: 1812 QELRGRLGEEDAGARARHKMTIAALESKLAQAEEQ-LEQETRERILSGKLVRRAEKRLKE 1870
Query: 361 ---QLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREA 417
Q+E +RR +L+ Q ++ ++ ++ + EE+ + RL E + + E+
Sbjct: 1871 VVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTES 1930
Query: 418 NEEL 421
E +
Sbjct: 1931 AESM 1934
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 95.1 bits (235), Expect = 2e-19
Identities = 129/537 (24%), Positives = 223/537 (41%), Gaps = 54/537 (10%)
Query: 180 LSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLL 239
LS + + Q+ + R + L +++ E AGLRE++ E ++L
Sbjct: 1368 LSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQL--EEEAAARERAGRELQ 1425
Query: 240 LLQSQLEQL----QEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKD 295
Q+QL + +EE LE+G E R E E L + + + L + + L+
Sbjct: 1426 TAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQ 1485
Query: 296 EMDELRQSSERAGQLEATLTSCRRRLGEL--RELRRQVRQLEERNAGHAE-RTRQLEDEL 352
E+D+ E+ QL +TL +R+ +L E +R +EER AE R R+
Sbjct: 1486 ELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGRERE----- 1540
Query: 353 RRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERD 412
RA SL LE ++ +EL +RQ A++A E E LL+ +D
Sbjct: 1541 ARALSLTRALEEEQEAREEL--ERQNRALRA-------------------ELEALLSSKD 1579
Query: 413 SLREANEELRCAQLQPRGLTQADPSLDPTSTPVDN--LAAEILPAELRETLLRLQLENKR 470
+ ++ EL A R QA L T +++ AAE L T+ L+ +++R
Sbjct: 1580 DVGKSVHELERA---CRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHER 1636
Query: 471 -LCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGG 529
L ++ A ER+ +L + L DA R Q L +L ++E+L+ + G
Sbjct: 1637 DLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQ 1696
Query: 530 KTEDAISILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKK 589
E+A+ L RK++ +++L E + RE I + + +R++ L+ + +
Sbjct: 1697 GKEEAVKQL--RKMQAQMKELWREVEETRTSREEIFS----QNRESEKRLKGLEAEVLRL 1750
Query: 590 DADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDF 649
+L A +R RR + R M A ++ + R+ + R+ LE +
Sbjct: 1751 QEEL-AASDRARRQAQQDRDEMAD------EVANGNLSKAAILEEKRQLEGRLGQLEEEL 1803
Query: 650 EKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQRLATNSRRGPLG 706
E+ +S E + + + E A A+S Q RG LG
Sbjct: 1804 EEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLG 1860
Score = 87.8 bits (216), Expect = 3e-17
Identities = 135/538 (25%), Positives = 220/538 (40%), Gaps = 84/538 (15%)
Query: 195 LDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQSQLEQLQEENFR 254
L + RQ +L Q L Q+ L+++ R GE LQ ++ QL+EE R
Sbjct: 903 LQVTRQDEVLQARAQEL-QKVQELQQQSAREVGE------------LQGRVAQLEEERAR 949
Query: 255 LESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDEL-RQSSERAGQLEAT 313
L E CAE E L R Q L + E +A E +E RQ +L+
Sbjct: 950 LAEQLRAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQH 1009
Query: 314 LTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRAQLEAQRRQVQELQ 373
+ L E E RQ QLE+ + ++ E++L ++L +R+ +++
Sbjct: 1010 IQELEAHL-EAEEGARQKLQLEKVTT--EAKMKKFEEDLLLLEDQNSKLSKERKLLEDRL 1066
Query: 374 GQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEELR------CAQLQ 427
+ +A + E+ + L KYE+ + E L + + R+ E+L+ ++LQ
Sbjct: 1067 AEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQ 1126
Query: 428 PRGLTQADPSLDPTSTPVDNLAAEI--LPAELRETLLRLQLENKRLCRQEAADRERQ--- 482
+ + Q + + L A++ EL+ L R + E + + RE Q
Sbjct: 1127 EQMVEQQQRA--------EELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAAL 1178
Query: 483 EELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDL---QKALQEQGGKTEDAISILL 539
E Q LE AR E Q R ++L LR ++ED A QE K E ++ L
Sbjct: 1179 AEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVT-EL 1237
Query: 540 KRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEER 599
K+ LEE ++HEA ++ R+R + + EL L++ A E
Sbjct: 1238 KKTLEEE-TRIHEAAVQELRQRH-------------GQALGELAEQLEQARRGKGAWE-- 1281
Query: 600 YRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEM----------DF 649
K R+ ++ + R EL SL+T +E + R R LE+ D
Sbjct: 1282 ------KTRLALEAEVSELR------AELSSLQTARQEGEQRRRRLELQLQEVQGRAGDG 1329
Query: 650 EKSRS------QREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQRLATNSR 701
E++R+ QR Q E +S N + R +E + AQ AQ+ L +R
Sbjct: 1330 ERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETR 1387
Score = 85.5 bits (210), Expect = 2e-16
Identities = 143/577 (24%), Positives = 243/577 (42%), Gaps = 57/577 (9%)
Query: 126 EKK--QDHIQRI---MTLEESV-QHVVMEAI--QELMTKDTPDSLSPETYGNFDSQSRRY 177
EKK Q HIQ + + EE Q + +E + + M K D L E + S+ R+
Sbjct: 1002 EKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKL 1061
Query: 178 YF--LSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTA 235
L+E + + E +++ L + + L E E+ +E GR E E
Sbjct: 1062 LEDRLAEFSSQAAEEEEKVKSLNK--LRLKYEATIADMEDRLRKEEKGRQELEKLKRRLD 1119
Query: 236 KKLLLLQSQLEQLQE--ENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQAL 293
+ LQ Q+ + Q+ E R + GR++E L+ A L R E R Q L SL + AL
Sbjct: 1120 GESSELQEQMVEQQQRAEELRAQLGRKEEELQAA-LARAEDEGGARAQLLKSLREAQAAL 1178
Query: 294 KDEMDELRQSSERAGQLEATLTSCRRRLGE-LRELRRQVRQ-LEERNAGHAERTRQLEDE 351
+ ++L SER + +A RR LGE L LR ++ L+ NA R+++ ++
Sbjct: 1179 AEAQEDLE--SERVARTKAEKQ--RRDLGEELEALRGELEDTLDSTNAQQELRSKREQEV 1234
Query: 352 LRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYE----SVTKEKERL 407
+L + VQEL+ + + + + L + R + +E ++ E L
Sbjct: 1235 TELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSEL 1294
Query: 408 LAERDSLREANEE---------LRCAQLQ------PRGLTQADPSLDPTSTPVDNLAAEI 452
AE SL+ A +E L+ ++Q R +A L ++N++ +
Sbjct: 1295 RAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGAL 1354
Query: 453 LPAELRETLLRLQLENKRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSE 512
AE + L +K L EA + QE LQ + RA+ L ++ R + + +
Sbjct: 1355 NEAESKTIRL-----SKELSSTEAQLHDAQELLQ----EETRAKLALGSRVRAMEAEAAG 1405
Query: 513 LRAQVEDLQKALQEQGGKTEDAISIL--LKRKLEEHLQKLHEADLELQRKREYIEELEP- 569
LR Q+E+ A + G + + A + L +R+ EE L + +R E L
Sbjct: 1406 LREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQR 1465
Query: 570 -PTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVD----KARMVMQTMEPKQRPAAGA 624
+ T R+E + LQ++ D E+ R+ V K R Q + ++ A
Sbjct: 1466 LAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRA 1525
Query: 625 PPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEEK 661
E + RER+ R L E+ + RE+ E+
Sbjct: 1526 VEERERAEAEGREREARALSLTRALEEEQEAREELER 1562
Score = 54.3 bits (129), Expect = 4e-07
Identities = 73/322 (22%), Positives = 142/322 (44%), Gaps = 38/322 (11%)
Query: 112 GKLLQLVLGCAISCEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFD 171
G+L +L A + + K++ ++++ ++ ++ + E + +++ S + E+
Sbjct: 1682 GELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLK 1741
Query: 172 SQSRRYYFLSEEAEEGD----ELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEG 227
L EE D + QQ ++ ++ + K ++ +E L R+G+ E
Sbjct: 1742 GLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEE 1801
Query: 228 EGTPGLTAKKLL-----LLQSQLEQLQEE-------NFRLESGREDERLRCAELEREVAE 275
E + +LL L Q+E L E + + ESGR+ +LER++ E
Sbjct: 1802 ELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQ-------QLERQIQE 1854
Query: 276 LQHR--NQALTSLAQEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQ 333
L+ R + + A+ + +L Q+ E+ Q R R+ + +RR ++
Sbjct: 1855 LRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQ------ETRERILSGKLVRRAEKR 1908
Query: 334 LEERNAGHAERTRQLEDELRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNL 393
L+E Q+E+E R A LR QLE +V++L+ Q +E +A + R L
Sbjct: 1909 LKEV-------VLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRL 1961
Query: 394 EEKYESVTKEKERLLAERDSLR 415
+ + E VT+ E + E +LR
Sbjct: 1962 QRELEDVTESAESMNREVTTLR 1983
Score = 44.7 bits (104), Expect = 3e-04
Identities = 56/244 (22%), Positives = 104/244 (42%), Gaps = 14/244 (5%)
Query: 189 ELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLL-----LQS 243
E ++R LE +++ L EE + + ++ E G +K +L L+
Sbjct: 1735 ESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEG 1794
Query: 244 QLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDELRQS 303
+L QL+EE +S E R +L +V L A S + +A++ + +++ RQ
Sbjct: 1795 RLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLE--RQI 1852
Query: 304 SERAGQLEATLTSCR-RRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRA-- 360
E G+L R R + L ++ Q EE+ R R L +L R R
Sbjct: 1853 QELRGRLGEEDAGARARHKMTIAALESKLAQAEEQ-LEQETRERILSGKLVRRAEKRLKE 1911
Query: 361 ---QLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREA 417
Q+E +RR +L+ Q ++ ++ ++ + EE+ + RL E + + E+
Sbjct: 1912 VVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTES 1971
Query: 418 NEEL 421
E +
Sbjct: 1972 AESM 1975
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 94.7 bits (234), Expect = 3e-19
Identities = 124/514 (24%), Positives = 242/514 (47%), Gaps = 65/514 (12%)
Query: 172 SQSRRYYFLSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTP 231
S R + LSE+ E +L++ ++E + L E + L Q+ +E+ G
Sbjct: 359 SLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREE-KEQHGLQLQSEIN 417
Query: 232 GLTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQE-- 289
L +K LL+++ QL E + RL+ R+ + + E++VA+LQ + L +E
Sbjct: 418 QLHSK---LLETE-RQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKV 473
Query: 290 --AQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQ 347
+ L+ ++D+ +Q + L+ + T+ +LRE + + Q+ RQ
Sbjct: 474 TNSTELQHQLDKTKQQHQEQQALQQSTTA------KLREAQNDLEQV----------LRQ 517
Query: 348 LEDELRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFEC---RNLEEK----YESV 400
+ D+ ++ +L A L+ + + L+ +R++ K + E L+EK E V
Sbjct: 518 IGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQV 577
Query: 401 TKEKERLLAERDSLREANEELRC-AQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRE 459
T+ E+L + +S ++A E L Q Q L A + T V+ L +++ ++ +
Sbjct: 578 TQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKV 637
Query: 460 TLLRLQLENKR--LCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQV 517
+ L +Q++ K L EAA ++ +LQ HL+ A A QQ+L+++ Q+
Sbjct: 638 SQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQD-------KQQELNKITTQL 690
Query: 518 EDLQKALQEQGGKTEDAISILLKRKLEEHLQKLHEADLELQRKREYIE----ELEPPT-- 571
+ + LQ+ K E +LE HL++ E L L++K E +E +LE +
Sbjct: 691 DQVTAKLQD---KQEHC------SQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLE 741
Query: 572 -DSSTARRIEELQHNLQ-KKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELH 629
+S + +++LQ Q D +LRA E + ++K + ++ +++ A L
Sbjct: 742 VKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEA-----LE 796
Query: 630 SLRTQLRERDVRIRHLEMDFEK-SRSQREQEEKL 662
S++ +L +++ + L+ DFE S+ + Q E+L
Sbjct: 797 SIKQKLTKQEEEKQILKQDFETLSQETKIQHEEL 830
Score = 86.7 bits (213), Expect = 7e-17
Identities = 119/501 (23%), Positives = 224/501 (44%), Gaps = 73/501 (14%)
Query: 190 LQQRCLDLERQLM---LLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQSQLE 246
L+Q DL+ L SEE + ++ GL+++ +P+G T ++ +L L+ QLE
Sbjct: 88 LRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTD--SSAELQSLEQQLE 145
Query: 247 QLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDELRQSSER 306
+ Q ENF ++ ++ + A+L E+A+++ + SL + A+ + E + ++
Sbjct: 146 EAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTE--ELNKE 203
Query: 307 AGQLEATLTSCRRRLG-----ELRELRRQVRQLEERNAGHAER-TRQLEDELRRAGSLRA 360
A ++ T +R G L++ QV+ L + ER + +L+DE ++ S A
Sbjct: 204 ATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYA 263
Query: 361 QLEAQRRQ---------------VQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKE 405
EA Q VQELQ + +K NL +K + TK +E
Sbjct: 264 SSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEE 323
Query: 406 RLLAERDSLREA-----NEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRET 460
+ E S + ++L C QLQ R L + T + + E+ +E E
Sbjct: 324 KHNEESVSKKNIQATLHQKDLDCQQLQSR--------LSASETSLHRIHVEL--SEKGEA 373
Query: 461 LLRLQLENKRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDL 520
+L+ E + + + ++LQ+ E+ + +HGL+ Q +NQ L +++ +
Sbjct: 374 TQKLKEELSEVETKYQHLKAEFKQLQQQREE--KEQHGLQLQSEINQ-----LHSKLLET 426
Query: 521 QKALQEQGGKTEDAISILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIE 580
++ L E G+ ++ L KL + Q++ + L+L R E ++ E T+S+
Sbjct: 427 ERQLGEAHGRLKEQRQ-LSSEKLMDKEQQVADLQLKLSRLEEQLK--EKVTNST------ 477
Query: 581 ELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDV 640
ELQH L K ++ + + + Q+ K R A +L + Q+ ++D
Sbjct: 478 ELQHQLDKT-----------KQQHQEQQALQQSTTAKLREAQN---DLEQVLRQIGDKDQ 523
Query: 641 RIRHLEMDFEKSRSQREQEEK 661
+I++LE +KS+ EK
Sbjct: 524 KIQNLEALLQKSKENISLLEK 544
Score = 70.1 bits (170), Expect = 7e-12
Identities = 115/522 (22%), Positives = 226/522 (43%), Gaps = 53/522 (10%)
Query: 104 EFSDPAELGKLLQLVLGCAISCEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLS 163
E S E+ K ++V + +KK + LE Q + + ++ + K ++LS
Sbjct: 769 ELSKQLEMEK--EIVSSTRLDLQKKSE------ALESIKQKLTKQEEEKQILKQDFETLS 820
Query: 164 PETYGNFDSQSRRYYFLSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMG 223
ET + + R E LQ+ ++ E + LS K L++ + L+
Sbjct: 821 QETKIQHEELNNRIQTTVTE------LQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKS 874
Query: 224 RPEGEGTPGL--------TAKKLL-LLQSQLEQLQEENFRLESGREDERLRCAELEREVA 274
E E G T K+L LQ Q+E +E L+ E E+ +L+ E+
Sbjct: 875 EFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELN 934
Query: 275 ELQHRN-QALTSLAQ---EAQALKDEMDELRQSSE-RAGQLEATLTSCRRRLGELRELRR 329
+Q + QA +L Q E Q L+ ++EL+QSSE + Q+EA + + + EL
Sbjct: 935 SMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELEN 994
Query: 330 QVRQLEERNAGHAERTRQLEDELRRAGSLRAQLEAQRRQVQELQGQ---RQEEAMKAEKW 386
+++Q + A ++L E + L+ E + ++LQ R+ E + +
Sbjct: 995 KLQQQLTQAA------QELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQ- 1047
Query: 387 LFECRNLEEKYESVTKEKERLLAERDSLREAN---EELRCAQLQ-PRGLTQADPSLDPTS 442
+ +++EEK ++ +E L++ R+ + N +EL+ A+ + + + L
Sbjct: 1048 --DLKSVEEK---LSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERC 1102
Query: 443 TPVDNLAAE--ILPAELRETLLRLQLENKRLCRQEAADRERQEELQRHLEDANRARHGLE 500
+ ++ E + EL +L + CRQE + EEL+ H ++ + L+
Sbjct: 1103 KALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLK 1162
Query: 501 TQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDAISILLKRKLEEHLQKLHEADLELQ-- 558
+L QQ EL+ + + L KA EQ + + + +K++ EE ++ E + +L
Sbjct: 1163 DAKQLLIQQKLELQGKADSL-KAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSE 1221
Query: 559 -RKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEER 599
+++E + ++ +I L NL + ++ + R
Sbjct: 1222 IKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRR 1263
Score = 67.8 bits (164), Expect = 3e-11
Identities = 104/541 (19%), Positives = 231/541 (42%), Gaps = 57/541 (10%)
Query: 173 QSRRYYFLSEEAEEGD-----ELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEG 227
+ R + +A EG+ +LQ++ L+ Q+ L+E+ ++ ++ + +E +
Sbjct: 544 KEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQ 603
Query: 228 EGTPGLTAK--KLLLLQSQLEQLQEENFRLESGRE-----DERLRCAE---LEREVAELQ 277
E L A ++L L++ + +L N +L +E D +++ L E A+
Sbjct: 604 EQKAHLRAAQDRVLSLETSVNEL---NSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTA 660
Query: 278 HRNQALTSLAQEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEER 337
R L AL+D+ EL + + + Q+ A L + +L +++ +E+
Sbjct: 661 QRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLES---HLKEYKEK 717
Query: 338 NAGHAERTRQLEDELRRAGSLRAQLEAQRRQ-VQELQGQRQEEAMKAEKWLFECRNLEEK 396
++T +LE ++++ + +++A + Q +Q+LQ QRQ + + LE +
Sbjct: 718 YLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEME 777
Query: 397 YESVTKEKERLLAERDSLREANEELRCAQLQPRGLTQADPSL--------DPTSTPVDNL 448
E V+ + L + ++L ++L + + + L Q +L + + +
Sbjct: 778 KEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTT 837
Query: 449 AAEILPAELRETLLRLQLENKRLCRQEAAD--RERQEELQRHLEDANRARHGLET----- 501
E+ ++ + L +L + + +D + + E ++ + A LE
Sbjct: 838 VTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKEL 897
Query: 502 QHRLNQQQLSELRAQVEDLQKALQEQ-----------GGKTEDAI----SILLKRKLEEH 546
+H+L Q + L+ Q E L+K+L+++ E I ++ K E+
Sbjct: 898 KHQLQVQMENTLKEQKE-LKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQ 956
Query: 547 LQ-KLHEADLELQRKREYIEELEPPTDSSTARRIE---ELQHNLQKKDADLRAMEERYRR 602
LQ ++E ++K++ IE L+ + ++ E +LQ L + +L A +E+
Sbjct: 957 LQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISV 1016
Query: 603 YVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEEKL 662
+ +T + Q G EL + R L+ + ++ + D +R+Q + KL
Sbjct: 1017 LQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKL 1076
Query: 663 L 663
+
Sbjct: 1077 I 1077
Score = 63.5 bits (153), Expect = 6e-10
Identities = 119/506 (23%), Positives = 220/506 (43%), Gaps = 73/506 (14%)
Query: 123 ISCEKKQDHIQ---RIMTLEESVQHVVMEAIQELMTK--DTPDSLSPETYGNFDSQSRRY 177
+S E K H + RI T +Q V ME + LMT+ D LS + +S+S
Sbjct: 819 LSQETKIQHEELNNRIQTTVTELQKVKMEK-EALMTELSTVKDKLSKVSDSLKNSKSE-- 875
Query: 178 YFLSEEAEEGD----ELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGL 233
+E ++G +L++ C +L+ QL + E +E E+ + L
Sbjct: 876 --FEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLEL 933
Query: 234 TAKKLLLLQSQ--LEQLQEENFRLE---------SGREDERLRCAELEREVAELQHRN-- 280
+ + L+Q+Q L+Q ++E +L+ S ++ +++ + E ++A LQ
Sbjct: 934 NSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELE 993
Query: 281 ----QALTSLAQEAQALKDEMDELRQSSERAGQLEATLTS-CRRRLGELRELRRQVRQLE 335
Q LT AQE A K+++ L+ + E++ + L S R EL R+ ++ +E
Sbjct: 994 NKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVE 1053
Query: 336 ER----------NAGHAERTRQLEDELRRAGSLRAQLEAQR-RQVQE----LQGQRQEEA 380
E+ N +L EL+ A + Q A++ +Q+QE LQ ++E++
Sbjct: 1054 EKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKS 1113
Query: 381 MKAEKWLFECRNLEEKYE-------SVTKEKERLLAER-DSLREANEELRCAQLQPRGLT 432
+K ++ + E L E E +TK E L + + +S++E QL +
Sbjct: 1114 LKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKL 1173
Query: 433 QADPSLDPTSTPVDNLAA--EILPAELR---ETLLRLQLENKRLCRQEAADRE------- 480
+ D V+ +IL +++ E L + +E + E ++E
Sbjct: 1174 ELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHE 1233
Query: 481 -RQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQ---KALQEQGGKTEDAIS 536
+ +L + N ++ + + +Q+++SEL Q +DL+ L+ +D
Sbjct: 1234 ENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERR 1293
Query: 537 ILLKR--KLEEHLQKLHEADLELQRK 560
LL+R K E ++KL LELQRK
Sbjct: 1294 ALLERCLKGEGEIEKLQTKVLELQRK 1319
Score = 41.2 bits (95), Expect = 0.003
Identities = 42/161 (26%), Positives = 81/161 (50%), Gaps = 24/161 (14%)
Query: 471 LCRQEAADRERQEELQRHLE---DA-NRARHGLETQHRLNQQQLSELRAQVEDLQKALQE 526
+C Q +EL +H E DA N + HG E+ L + ++ LR +V+DLQ +L+E
Sbjct: 42 ICPQCMKSLGSADELFKHYEAVHDAGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKE 101
Query: 527 QGGKTEDAISILLKRKLEEH--LQK--------LHEADLELQRKREYIEELEPPTDSSTA 576
+ +E+ LK++LE++ LQ+ + ++ ELQ + +EE + T++
Sbjct: 102 EKWYSEE-----LKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQ--TENFNI 154
Query: 577 RRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPK 617
+++++L ++K A L + D+ R + + E K
Sbjct: 155 KQMKDL---FEQKAAQLATEIADIKSKYDEERSLREAAEQK 192
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 90.9 bits (224), Expect = 4e-18
Identities = 126/547 (23%), Positives = 238/547 (43%), Gaps = 82/547 (14%)
Query: 185 EEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLL---- 240
EE + R +LE +++ L +EK L + E + E E GL K+LL
Sbjct: 865 EELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAE-ERCEGLIKSKILLEAKV 923
Query: 241 --LQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMD 298
L +LE+ +E N L + + + +C+ L+R++ +L+ LT + +E A ++++
Sbjct: 924 KELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLE---LTLTKVEKEKHATENKVK 980
Query: 299 ELRQSSERAGQLEATLTSCRRRLGELRELRRQ-----------VRQLEERNAGHAERTRQ 347
L SE LE ++ + L+E +Q V L + NA ++T
Sbjct: 981 NL---SEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDD 1037
Query: 348 LEDELRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERL 407
LE L + LRA LE +R+++ QE M E + + +EEK + E +L
Sbjct: 1038 LEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLEN---DKQQIEEKLKKKEFELSQL 1094
Query: 408 LAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLE 467
A+ D +E++ Q Q + + ++ L EI E LR ++E
Sbjct: 1095 QAKID-----DEQVHSLQFQKK--------IKELQARIEELEEEI----EAEHTLRAKIE 1137
Query: 468 NKRLCRQEAADRERQ-EELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQE 526
+R +D R+ EE+ LE+A+ A Q +N+++ +E + DL++A +
Sbjct: 1138 KQR------SDLARELEEISERLEEASGA---TSAQIEMNKKREAEFQKMRRDLEEATLQ 1188
Query: 527 QGGKTEDAISILLKRKLEEHLQKLHEADLELQRKREYIE----ELEPPTD---------S 573
+A + L++K + + +L E LQR ++ +E EL+ D S
Sbjct: 1189 -----HEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALS 1243
Query: 574 STARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRT 633
+ IE ++ + ++++A +E+ + + M ++ + + E SL +
Sbjct: 1244 KSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLIS 1303
Query: 634 QLRERDVRIRHLEMDFEKSRSQREQEEK-------LLISAWYNMGMALQQRAGEERAPAH 686
QL + + L E+ + Q E+E K L S+ ++ + +Q E+ A A
Sbjct: 1304 QLTKSK---QALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAE 1360
Query: 687 AQSFLAQ 693
Q L++
Sbjct: 1361 LQRALSK 1367
Score = 71.2 bits (173), Expect = 3e-12
Identities = 111/513 (21%), Positives = 209/513 (40%), Gaps = 69/513 (13%)
Query: 189 ELQQRCLDLERQLML-------LSEEKQSLAQENAGLRERMGRPEGEGTPGL--TAKKLL 239
ELQ R +LE ++ + +++ LA+E + ER+ G + + K+
Sbjct: 1114 ELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREA 1173
Query: 240 LLQSQLEQLQEENFRLESG----REDERLRCAELEREVAELQHRNQALTSLAQEAQALKD 295
Q L+E + E+ R+ + AEL ++ LQ Q L +E LK
Sbjct: 1174 EFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQ---KLEKEKSELKM 1230
Query: 296 EMDELRQS----SERAGQLEATLTSCRRRLGELR-----------ELRRQVRQLEERNAG 340
E+D++ + S+ +E T + + E++ +L Q +L+ +N
Sbjct: 1231 EIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGE 1290
Query: 341 HAERTRQLEDEL----RRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEK 396
+ R + E + + +L QLE +RQ++E + A + +C L E+
Sbjct: 1291 LSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQ 1350
Query: 397 YESVTKEKERLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAE 456
YE + K L + +L +AN E+ AQ + + T A + LA + AE
Sbjct: 1351 YEEEQEAKAEL---QRALSKANSEV--AQWRTKYETDAIQRTEELEEAKKKLAQRLQEAE 1405
Query: 457 LRETLLRLQLENKRLCRQEAADRERQ--------EELQRHLEDANRARHGLETQHRLNQQ 508
EN + A E+ E+L R LE ++ A L+ + R +
Sbjct: 1406 ----------ENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDK 1455
Query: 509 QLSELRAQVEDLQKALQEQGGKTEDAISILLKRK--LEEHLQKLHEADLELQRKREYIEE 566
L+E + ++++ Q L+ ++ + L K + EE + +L E + +E I +
Sbjct: 1456 VLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISD 1515
Query: 567 LEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPP 626
L +I E NLQ+ + + +E+ V ++E ++
Sbjct: 1516 L--------TEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQL 1567
Query: 627 ELHSLRTQLRERDVRIRHLEMDFEKSRSQREQE 659
EL ++++L +R V + E++ K SQR E
Sbjct: 1568 ELSQVKSEL-DRKVIEKDEEIEQLKRNSQRAAE 1599
Score = 65.1 bits (157), Expect = 2e-10
Identities = 120/543 (22%), Positives = 221/543 (40%), Gaps = 98/543 (18%)
Query: 180 LSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLL 239
+ EE + + + LL E+ + + A L+ + + E T +
Sbjct: 1323 MEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETD 1382
Query: 240 LLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDE 299
+Q + E+L+E +L +RL+ AE E A N SL + Q L+ E+++
Sbjct: 1383 AIQ-RTEELEEAKKKLA-----QRLQEAEENTETA-----NSKCASLEKTKQRLQGEVED 1431
Query: 300 LRQSSERAGQLEATLTSCRRRLGE-LRELRRQVRQLEERNAGHAERTRQLEDELRRAGSL 358
L + ER+ ATL +R + L E ++++ + + + +R L EL + +
Sbjct: 1432 LMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNA 1491
Query: 359 RA----QLEAQRRQVQELQ-------------GQRQEEAMKAEKWLFECRN-----LEEK 396
QLE RR+ + LQ G+ +EA K +K + + ++ LEE
Sbjct: 1492 YEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEV 1551
Query: 397 YESVTKEKERLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAA---EIL 453
S+ E+ ++L + L + EL R + + D ++ A +L
Sbjct: 1552 EGSLEHEESKILRVQLELSQVKSEL------DRKVIEKDEEIEQLKRNSQRAAEALQSVL 1605
Query: 454 PAELR-----------------ETLLRLQLENKRLCRQEAADRERQEEL---QRHLEDAN 493
AE+R E ++L N+++ + R Q +L Q HL+DA
Sbjct: 1606 DAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDAL 1665
Query: 494 RARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKT-----------EDAISIL---- 538
R+ L+ Q + +++ L ++E+++ AL EQ +T D + +L
Sbjct: 1666 RSNEDLKEQLAIVERRNGLLLEELEEMKVAL-EQTERTRRLSEQELLDASDRVQLLHSQN 1724
Query: 539 -----LKRKLEEHLQKLH-EADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDAD 592
K+KLE + + E + +Q R EE + A EEL KK+ D
Sbjct: 1725 TSLINTKKKLEADIAQCQAEVENSIQESRN-AEEKAKKAITDAAMMAEEL-----KKEQD 1778
Query: 593 LRAMEERYRRYVDKARMVMQTM--EPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFE 650
A ER ++ +++ +Q E +Q G ++ L ++RE + E+D E
Sbjct: 1779 TSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELE-----NELDVE 1833
Query: 651 KSR 653
+ R
Sbjct: 1834 QKR 1836
Score = 61.6 bits (148), Expect = 2e-09
Identities = 70/290 (24%), Positives = 133/290 (45%), Gaps = 41/290 (14%)
Query: 180 LSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLL 239
L + ++L+++ +ER+ LL EE + + ++ + E T L+ ++LL
Sbjct: 1661 LDDALRSNEDLKEQLAIVERRNGLLLEELEEM---------KVALEQTERTRRLSEQELL 1711
Query: 240 LLQSQLEQLQEENFRLESGR---EDERLRC-AELEREVAELQHRNQ----ALTSLAQEAQ 291
+++ L +N L + + E + +C AE+E + E ++ + A+T A A+
Sbjct: 1712 DASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAE 1771
Query: 292 ALKDEMDELRQSSERAGQLEATLTSCRRRLGELREL-----RRQVRQLEERNAGHAERTR 346
LK E D LE T+ + RL E +L ++Q+++LE R R
Sbjct: 1772 ELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLE-------NRVR 1824
Query: 347 QLEDEL----RRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTK 402
+LE+EL +R R+V+E+ Q +E+ K + ++L +K ++ K
Sbjct: 1825 ELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEED----HKNILRLQDLVDKLQAKVK 1880
Query: 403 EKERLLAERDSLREANEEL-RCAQLQPRGLTQADPSLDPTSTPVDNLAAE 451
+R E + +AN +L RC ++Q L +A D + V+ L A+
Sbjct: 1881 SYKRQAEEAE--EQANTQLSRCRRVQ-HELEEAAERADIAESQVNKLRAK 1927
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 90.5 bits (223), Expect = 5e-18
Identities = 137/592 (23%), Positives = 233/592 (39%), Gaps = 101/592 (17%)
Query: 185 EEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQSQ 244
+E ++LQ+ + +RQ L EE+Q E LR E + ++ L + Q
Sbjct: 255 KEEEKLQEE--EPQRQRELQEEEEQLRKLERQELRRERQEEEQQ-------QQRLRREQQ 305
Query: 245 LEQLQEENFR--LESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDELRQ 302
L + QEE R E RE + R + ER +L+ + +E Q +++ +E R+
Sbjct: 306 LRRKQEEERREQQEERREQQERREQQEERREQQLRREQEE----RREQQLRREQEEERRE 361
Query: 303 SSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQL--------EDELRR 354
R Q E RR +LR ++ R+ + R R +QL E +LRR
Sbjct: 362 QQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRR 421
Query: 355 AGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSL 414
LR + E +R + + Q +R++ + ++ + EE+ E +E+ + +RD
Sbjct: 422 EQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQE 481
Query: 415 REANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQ 474
E E + + R Q E RE LR + E +R Q
Sbjct: 482 EERRERWLKLEEEERREQQ----------------------ERREQQLRREQEERR--EQ 517
Query: 475 EAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDA 534
+E +E LQ+ L + R E + ++ E R + E ++ L+ + + D
Sbjct: 518 RLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQ 577
Query: 535 ISILLKRKLEEHLQKL---HEADLELQRKREYIEELEP---------------------- 569
LLKR+ E Q+L E LE + KRE +E LE
Sbjct: 578 ---LLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLL 634
Query: 570 PTDSSTARRIEELQHNLQ-------KKDADLRAMEERYRRYVDKARMVMQTMEPKQRPA- 621
++ RR ++L+ Q K++ + +E+R +R ++ R + E +Q A
Sbjct: 635 KSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQAR 694
Query: 622 ----AGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEEKLLIS----AWYNMGMA 673
+ P L ++ R ++ E R ++EQEEK W A
Sbjct: 695 ERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERA 754
Query: 674 LQQRAGEERA-------PAHAQSFLAQQRLATNSRRGPLGRLASLNLRPTDK 718
+Q+ EE+ A +S +QRL S R PL LR ++
Sbjct: 755 HRQQQEEEQRRDFTWQWQAEEKSERGRQRL---SARPPLREQRERQLRAEER 803
Score = 86.7 bits (213), Expect = 7e-17
Identities = 115/493 (23%), Positives = 206/493 (41%), Gaps = 56/493 (11%)
Query: 177 YYFLSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAK 236
YY L + +E + RC E LL + +Q Q R+R E PG +
Sbjct: 86 YYALGQATGLDEEKRARCDGKES---LLQDRRQEEDQRRFEPRDRQLEEE----PGQRRR 138
Query: 237 KLLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDE 296
Q + EQ +E E + ERL + +R EL + Q QE + + E
Sbjct: 139 -----QKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEW----QEREERRAE 189
Query: 297 MDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQL--EDELRR 354
++L+ + RRR EL ELRR+ R EE+ ER ++ E+E +
Sbjct: 190 EEQLQSCKGHETEEFPDEEQLRRR--ELLELRRKGR--EEKQQQRRERQDRVFQEEEEKE 245
Query: 355 AGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWL--FECRNLEEKYESVTKEKERLLAERD 412
L + ++QE + QRQ E + E+ L E + L + + ++++RL E+
Sbjct: 246 WRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQ 305
Query: 413 SLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKR-- 470
R+ EE R Q + R + + E RE LR + E +R
Sbjct: 306 LRRKQEEERREQQEERREQQERREQQE----------------ERREQQLRREQEERREQ 349
Query: 471 LCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGK 530
R+E + R+++L+R E+ R + L + +L ++Q Q+ Q+ +EQ
Sbjct: 350 QLRREQEEERREQQLRREQEEERREQQ-LRREQQLRREQQLRREQQLRREQQLRREQ--- 405
Query: 531 TEDAISILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKD 590
+ + E+ L++ + E Q +RE EE RR + L+ +++
Sbjct: 406 ---------QLRREQQLRREQQLRREQQLRREQEEERHEQKHEQ-ERREQRLKREQEERR 455
Query: 591 ADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFE 650
L+ EE R ++ + ++ + ++R E R Q R+ ++R + +
Sbjct: 456 DWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERR 515
Query: 651 KSRSQREQEEKLL 663
+ R +R++EE+ L
Sbjct: 516 EQRLKRQEEEERL 528
Score = 86.3 bits (212), Expect = 9e-17
Identities = 120/512 (23%), Positives = 213/512 (41%), Gaps = 45/512 (8%)
Query: 173 QSRRYYFLSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPG 232
Q R F EE + + + R E Q + E ++ +E LR+ R E
Sbjct: 1410 QDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFRE---- 1465
Query: 233 LTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQA 292
++ LL + + +QL + + E+++LR E +R + R Q L S E +
Sbjct: 1466 ---EEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDR-----KFREQELRSQEPERKF 1517
Query: 293 LKDEMDELRQSSER-----AGQLEATLTSCRRRLGELRELR--RQVRQ-LEERNAGHAER 344
L++E RQ +R QL +RR R+ R Q+RQ EE+ ER
Sbjct: 1518 LEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQER 1577
Query: 345 TRQL---EDELRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVT 401
R+ E ++RR R +E +Q++ +GQ+Q + K+ + + L+E+ E
Sbjct: 1578 DRKFRLEEQKVRRQEQERKFME-DEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQL 1636
Query: 402 KEKER---LLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELR 458
+ER L E LR E + + R + + L L + + R
Sbjct: 1637 HRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEE--QQLRRQERDRKFR 1694
Query: 459 ETLLRLQLENKRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQL------SE 512
E +L+ + + + + R++EL+R + + R E + Q++ +
Sbjct: 1695 EEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQ 1754
Query: 513 LRAQVEDLQKALQEQGGKTEDAISILLKRKLEEHLQKLHEADLELQRKREYIEELEP--- 569
LR + E+ Q QE+ K + L+++ EE + E+D + + + + +E E
Sbjct: 1755 LRPEREEQQLRRQERDRKFREEEQ--LRQEREEQQLRSQESDRKFREEEQLRQEREEQQL 1812
Query: 570 -PTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPEL 628
P R EE Q L++++ LR +ER R+Y +A T E +R E
Sbjct: 1813 RPQQRDGKYRWEEEQLQLEEQEQRLR--QERDRQY--RAEEQFATQEKSRREEQELWQEE 1868
Query: 629 HSLRTQLRERDVRIRHLEMDFEKSRSQREQEE 660
R Q RER +R H+ ++ + R+ E
Sbjct: 1869 EQKRRQERERKLREEHIRRQQKEEQRHRQVGE 1900
Score = 85.5 bits (210), Expect = 2e-16
Identities = 132/554 (23%), Positives = 235/554 (42%), Gaps = 71/554 (12%)
Query: 171 DSQSRRYYFLSEEAEEGDELQQRCLDLERQLMLLSEEKQS--LAQENAGLRERMGRPEGE 228
+ + RR + EE E E ++R L+R EE++ L E RE+ R E +
Sbjct: 450 EQEERRDWLKREEETERHEQERRKQQLKRDQ---EEERRERWLKLEEEERREQQERREQQ 506
Query: 229 GTPGLTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQ 288
L ++ + +L++ +EE + R +++LR + ER L+ + +
Sbjct: 507 ----LRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQER 562
Query: 289 EAQALKDEMDE-----LRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAE 343
Q LK E +E L++ ER Q L + E R R +V +LE+
Sbjct: 563 REQRLKREQEERRDQLLKREEERRQQ---RLKREQEERLEQRLKREEVERLEQEERREQR 619
Query: 344 RTRQLEDELRRAGSLRAQLEAQRRQVQ--ELQGQRQEEAMKAEKWLFECRNLEE--KYES 399
R+ +E RR L+++ + +RRQ Q Q +R+E+ +K E+ E LE+ K E
Sbjct: 620 LKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREE---EEERLEQRLKREH 676
Query: 400 VTKEKERLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRE 459
+ +E+ LAE + +A E ++ P+ Q + D + V + P +
Sbjct: 677 EEERREQELAEEEQ-EQARERIKSRI--PKWQWQLESEADARQSKVYSR-----PRKQEG 728
Query: 460 TLLRLQLENKRLCRQ--------EAADRERQEELQRH--------LEDANRARHGLETQH 503
R + E KR R+ E A R++QEE QR E + R R L +
Sbjct: 729 QRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARP 788
Query: 504 RLNQQQLSELRAQVEDLQKALQEQGGKTEDAISILLKRKLEEHLQKLHEADLELQRKREY 563
L +Q+ +LRA+ ++ +EQ E EE ++ E +++ ++
Sbjct: 789 PLREQRERQLRAE----ERQQREQRFLPE-----------EEEKEQRRRQRREREKELQF 833
Query: 564 IEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAG 623
+EE E A++++E + LQ+ R+ E+R + K R ++ ++R
Sbjct: 834 LEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQ---KWRWQLEEERKRRRHTLY 890
Query: 624 APPELHSLRTQLRERDVRIRHLEMDF--EKSRSQREQEEKLLISAWYNMGMALQQRAGEE 681
A P +L+ QLR+ ++ E + E+ +R QE++ + +Q EE
Sbjct: 891 AKP---ALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREE 947
Query: 682 RAPAHAQSFLAQQR 695
R Q Q R
Sbjct: 948 REKRRRQERERQYR 961
Score = 84.0 bits (206), Expect = 5e-16
Identities = 117/498 (23%), Positives = 206/498 (41%), Gaps = 47/498 (9%)
Query: 183 EAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQ 242
E E G +Q+ + ER+L E+QS QE R+R R E ++ +
Sbjct: 130 EEEPGQRRRQKRQEQERELA--EGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERR 187
Query: 243 SQLEQLQE-ENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDELR 301
++ EQLQ + E ++E+LR RE+ EL+ + + ++ Q ++ D +
Sbjct: 188 AEEEQLQSCKGHETEEFPDEEQLR----RRELLELRRKGR-----EEKQQQRRERQDRVF 238
Query: 302 QSSERA--GQLEATLTSCRRRLGE-----LRELRRQVRQLEERNAGHAERTRQLEDE--- 351
Q E + E L +L E REL+ + QL + R RQ E++
Sbjct: 239 QEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQ 298
Query: 352 -LRRAGSLRAQLEAQRRQVQE---LQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERL 407
LRR LR + E +RR+ QE Q +R+E+ + + E + + + +E+E
Sbjct: 299 RLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEE 358
Query: 408 LAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLE 467
E+ RE EE R QL+ + + L L E ++ QL
Sbjct: 359 RREQQLRREQEEERREQQLRREQQLRREQQL----RREQQLRREQQLRREQQLRREQQLR 414
Query: 468 NKRLCRQEAADRERQEE---LQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKAL 524
++ R+E R QEE Q+H ++ R E + R + + E + E ++
Sbjct: 415 REQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQ 474
Query: 525 QEQGGKTEDAISILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQH 584
Q + + E+ LK + EE ++ + +L+R++E E E LQ
Sbjct: 475 QLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEE----ERLQQ 530
Query: 585 NLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRH 644
L+ + R EER + + + E +++ L+ + ER ++
Sbjct: 531 RLRSEQQLRREQEERREQLLKREEEKRLEQERREQ----------RLKREQEERRDQLLK 580
Query: 645 LEMDFEKSRSQREQEEKL 662
E + + R +REQEE+L
Sbjct: 581 REEERRQQRLKREQEERL 598
Score = 84.0 bits (206), Expect = 5e-16
Identities = 144/605 (23%), Positives = 257/605 (42%), Gaps = 113/605 (18%)
Query: 127 KKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYFLSEEAEE 186
++++ + + LEE Q E Q+L ++ D L + + RR + EE
Sbjct: 823 QRREREKELQFLEEEEQLQRRERAQQLQEEE--DGLQEDQERRRSQEQRRDQKWRWQLEE 880
Query: 187 GDELQQRCL--------DLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGT----PGLT 234
+ ++ L L ++ LL EE++ L +E RE+ R E E L
Sbjct: 881 ERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREE---REKRRRQEQERQYREEEQLQ 937
Query: 235 AKKLLLLQSQLE----QLQEENFRLES----------GREDERLRCAELE---REVAELQ 277
++ LL+ + E Q +E +R + G E E+ R E E RE ELQ
Sbjct: 938 QEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQ 997
Query: 278 HRNQALTSLAQEAQALKD------EMDELRQSSERAGQLEATLTSCRRRLGELRELRRQV 331
+ L +E + ++ + DEL+Q E+ + E + R + RE ++
Sbjct: 998 QEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYRE-EEEL 1056
Query: 332 RQLEERNAGHAERTRQLEDELRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECR 391
+Q EE+ G TR+ R +LE Q R+ +ELQ Q +E+ ++ E E R
Sbjct: 1057 QQEEEQLLGEERETRR-----------RQELERQYRKEEELQ-QEEEQLLREEP---EKR 1101
Query: 392 NLEEKYESVTKEKERLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAE 451
+E+ +E+E E LRE E+ R +L+ + + + + + L E
Sbjct: 1102 RRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEE-----EQLLRE 1156
Query: 452 ILPAELRETLLR-------LQLENKRLCRQEAADRERQEELQRHLEDANRARHGLETQHR 504
R+ L R LQ E ++L R+E ++ RQE +++ E+ R + ++R
Sbjct: 1157 EPEKRRRQELERQYREEEELQQEEEQLLREE-QEKRRQERERQYREEEELQRQKRKQRYR 1215
Query: 505 LNQQQLSELRAQVE-DLQKALQ-----------EQGGKTEDAISILLKRKLEEHLQKL-- 550
++ Q S+L+ Q E + + A++ EQ + ED S L R+ ++ LQ L
Sbjct: 1216 -DEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLED--SQLRDRQSQQDLQHLLG 1272
Query: 551 --HEADLELQRKR-----------EYIEELEPPTDSSTARRIEELQHNLQKKDADLRAME 597
E D E +R+R E +E E R+ +E + L+++ + R +
Sbjct: 1273 EQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQ 1332
Query: 598 ERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQRE 657
E R++ ++ +++ + E LR Q R+R R L E+ R E
Sbjct: 1333 ETDRKFREEEQLLQEREE-------------QPLRRQERDRKFREEELRHQ-EQGRKFLE 1378
Query: 658 QEEKL 662
+E++L
Sbjct: 1379 EEQRL 1383
Score = 84.0 bits (206), Expect = 5e-16
Identities = 134/509 (26%), Positives = 210/509 (41%), Gaps = 105/509 (20%)
Query: 171 DSQSRRYYFLSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGT 230
+ + RR + + DELQQ E QL+ EK+ L + RER R E E
Sbjct: 1007 EREKRRRQEWERQYRKKDELQQE----EEQLLREEREKRRLQE-----RERQYREEEE-- 1055
Query: 231 PGLTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEA 290
LQ + EQL G E E R ELER+ + + Q +E
Sbjct: 1056 ----------LQQEEEQLL--------GEERETRRRQELERQYRKEEELQQ------EEE 1091
Query: 291 QALKDEMDELR-QSSERAGQLEATLTSCRRRLGELRELRRQVRQLE-ERNAGHAERTRQL 348
Q L++E ++ R Q ER + E L +L LRE R + R+ E ER E +Q
Sbjct: 1092 QLLREEPEKRRRQERERQCREEEELQQEEEQL--LREEREKRRRQELERQYREEEEVQQE 1149
Query: 349 EDELRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLL 408
E++L LR + E +RRQ E Q + +EE + E+ L L E+ E +E+ER
Sbjct: 1150 EEQL-----LREEPEKRRRQELERQYREEEELQQEEEQL-----LREEQEKRRQERERQY 1199
Query: 409 AERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLEN 468
E + L+ + R R + + + DN + RE QLE+
Sbjct: 1200 REEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVY----CKGRENEQFRQLED 1255
Query: 469 KRLCRQEAADRERQEELQRHL-EDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQ 527
+L DR+ Q++LQ L E R R Q R QQ + E L++ Q++
Sbjct: 1256 SQL-----RDRQSQQDLQHLLGEQQERDRE----QERRRWQQRDRHFPEEEQLEREEQKE 1306
Query: 528 GGKTEDAISILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQ 587
+ + RK +E Q L E E +R++E T R+ E + LQ
Sbjct: 1307 AKRRD--------RKSQEEKQLLREEREEKRRRQE------------TDRKFREEEQLLQ 1346
Query: 588 KKDADLRAMEERYRRYVDKARMVMQT----MEPKQRPAAGAPPELHSLRTQLRER----- 638
+++ +ER R++ ++ + +E +QR LR Q RER
Sbjct: 1347 EREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQR-----------LRRQERERKFLKE 1395
Query: 639 --DVRIRHLEMDFEKSRSQREQEEKLLIS 665
+R + E + R ++ +EE+ +S
Sbjct: 1396 EQQLRCQEREQQLRQDRDRKFREEEQQLS 1424
Score = 73.9 bits (180), Expect = 5e-13
Identities = 107/491 (21%), Positives = 210/491 (42%), Gaps = 63/491 (12%)
Query: 182 EEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLL 241
E+ + E +QR ER+ L EE+Q QE
Sbjct: 1371 EQGRKFLEEEQRLRRQERERKFLKEEQQLRCQER-------------------------- 1404
Query: 242 QSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDELR 301
+ QL Q ++ FR E+++L E +R+ E Q + +E + L++E +LR
Sbjct: 1405 EQQLRQDRDRKFR----EEEQQLSRQERDRKFRE---EEQQVRRQERERKFLEEE-QQLR 1456
Query: 302 QSSERAGQLEATLTSCRRRLGELRELRRQVRQL----EERNAGHAERTRQL-EDELRRAG 356
Q R + E L R E ++L RQ R EE+ ER R+ E ELR
Sbjct: 1457 QERHRKFREEEQLLQER----EEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQE 1512
Query: 357 SLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLRE 416
R LE +++ ++ QRQ + ++ E+ L +E+ + ++++R E + LR+
Sbjct: 1513 PERKFLEEEQQLHRQ---QRQRKFLQEEQQL----RRQERGQQRRQDRDRKFREEEQLRQ 1565
Query: 417 ANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQEA 476
EE + ++ + + + + +E +L+ E R R++
Sbjct: 1566 EREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDE 1625
Query: 477 ADRERQEELQRHLEDANRARHGLETQHRLNQQQL-SELRAQVEDLQKALQEQGGKTEDAI 535
+ +EE Q H ++ R R LE + +L +Q+ +LR D + +E+ ++
Sbjct: 1626 QLLQEREEQQLHRQE--RDRKFLEEEPQLRRQEREQQLR---HDRDRKFREEEQLLQEGE 1680
Query: 536 SILLKRKLEEHLQKLHEADLEL---QRKREYIEELEPPTDSSTARRIEELQHNLQKKDAD 592
L+R +E +K E + +L +R+R++++E + R+ E + Q+ + +
Sbjct: 1681 EQQLRR--QERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQE 1738
Query: 593 LRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPP--ELHSLRTQLRERDVRIRHLEMDFE 650
+ERYR+ +++ ++ + E + R E LR + E+ +R + + F
Sbjct: 1739 QLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFR 1798
Query: 651 KSRSQREQEEK 661
+ R++ E+
Sbjct: 1799 EEEQLRQEREE 1809
Score = 72.4 bits (176), Expect = 1e-12
Identities = 119/460 (25%), Positives = 201/460 (43%), Gaps = 62/460 (13%)
Query: 246 EQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDEL---RQ 302
EQL+ E + R+ + +L RE E + R Q +E + L E +E RQ
Sbjct: 1297 EQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQ 1356
Query: 303 SSERAGQLEATL--TSCRRRLGELRELRRQVRQ----LEERNAGHAERTRQL-EDELRRA 355
+R + E R+ L E + LRRQ R+ EE+ ER +QL +D R+
Sbjct: 1357 ERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKF 1416
Query: 356 GSLRAQLEAQRR----QVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAER 411
QL Q R + +E Q +RQE + K+L E + L ++ +E+E+LL ER
Sbjct: 1417 REEEQQLSRQERDRKFREEEQQVRRQE---RERKFLEEEQQLRQERHRKFREEEQLLQER 1473
Query: 412 DSL--------REANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLR 463
+ R+ EE + + Q R + L + P E ++ +
Sbjct: 1474 EEQQLHRQERDRKFLEEEQQLRRQERDRKFREQEL-RSQEPERKFLEEEQQLHRQQRQRK 1532
Query: 464 LQLENKRLCRQEAADRERQ---------EELQRHLEDANRARHGLETQHRLNQQQL---S 511
E ++L RQE + RQ E+L++ E+ +R + + RL +Q++
Sbjct: 1533 FLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQE 1592
Query: 512 ELRAQVEDLQKALQEQGGKTEDAISILLKRKLEEHLQKLHEADLELQ-RKREYIEELEPP 570
+ R +ED Q+ +++G + R+ E+ LQ+ E L Q R R+++EE EP
Sbjct: 1593 QERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEE-EP- 1650
Query: 571 TDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHS 630
R ++L+H+ +K + EE+ + ++ ++ Q + K R E
Sbjct: 1651 -QLRRQEREQQLRHDRDRKFRE----EEQLLQEGEEQQLRRQERDRKFR------EEEQQ 1699
Query: 631 LRTQLRER-------DVRIRHLEMDF---EKSRSQREQEE 660
LR Q RER +R + LE F E+ R + EQE+
Sbjct: 1700 LRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQ 1739
Score = 54.3 bits (129), Expect = 4e-07
Identities = 80/294 (27%), Positives = 128/294 (43%), Gaps = 30/294 (10%)
Query: 147 MEAIQELMTKDTPDSLSPETYGNFDSQSRRYYFLSEEAEEGDELQQRCLDLERQLMLLSE 206
ME Q+L ++ L E D + R L +E EE +Q ER L E
Sbjct: 1598 MEDEQQLRRQEGQQQLRQER----DRKFREDEQLLQEREEQQLHRQ-----ERDRKFLEE 1648
Query: 207 EKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQSQLEQLQEENFRLESGREDERLRC 266
E Q QE RE+ R + + ++ LL + + +QL+ + + E+++LR
Sbjct: 1649 EPQLRRQE----REQQLRHDRDRK--FREEEQLLQEGEEQQLRRQERDRKFREEEQQLRR 1702
Query: 267 AELEREVA--ELQHRNQALTSLAQEAQALKDE--MDELRQSSERAGQLEATLTSCRRRLG 322
E ER+ E Q R Q L +E + L+ E ++LR+ LE R
Sbjct: 1703 QERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPER--- 1759
Query: 323 ELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRA-QLEAQRRQVQELQGQRQEEAM 381
E ++LRRQ R + R + R+ E +LR S R + E Q RQ +E Q R ++
Sbjct: 1760 EEQQLRRQERDRKFREEEQLRQERE-EQQLRSQESDRKFREEEQLRQEREEQQLRPQQRD 1818
Query: 382 KAEKWLFECRNLEEKYESVTKEKER------LLAERDSLREANEELRCAQLQPR 429
+W E LEE+ + + +E++R A ++ R +EL + Q R
Sbjct: 1819 GKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKR 1872
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 89.7 bits (221), Expect = 8e-18
Identities = 144/626 (23%), Positives = 270/626 (43%), Gaps = 74/626 (11%)
Query: 126 EKKQDHIQRIMTLEESVQHVV--MEAIQELMTK------DTPDSLSPETYGNF----DSQ 173
++K+D + + L+ ++ + A QEL TK + +L ET + D +
Sbjct: 1139 KQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMR 1198
Query: 174 SRRYYFLSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGL 233
R L E +E+ ++ ++ +LE+ L + + LA E L++ E +
Sbjct: 1199 QRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHK----- 1253
Query: 234 TAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQAL 293
KKL Q+QE + ++ G +RLR EL + ++LQ+ +++L +EA+
Sbjct: 1254 -RKKLDA------QVQELHAKVSEG---DRLR-VELAEKASKLQNELDNVSTLLEEAE-- 1300
Query: 294 KDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELR 353
K + + ++ QL+ T + + L ++RQLEE E+ + E+E R
Sbjct: 1301 KKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEE-EEEAR 1359
Query: 354 R-----AGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFEC----RNLEEK---YESVT 401
+ +L++QL +++V + G + +K L + + LEEK Y+ +
Sbjct: 1360 KNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLE 1419
Query: 402 KEKERLLAERDSL-------REANEELRCAQLQPRGLTQADPSLDPT-STPVDNLAAEIL 453
K K RL E D L R+ L Q + L + S+ + D AE
Sbjct: 1420 KTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAR 1479
Query: 454 PAELRETLLRLQLENKRLCRQEAADRERQ-----EELQRHLEDANRARHGLETQHRLNQQ 508
E + L LE ++E + +Q E+L +D + H LE R +Q
Sbjct: 1480 EKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQ 1539
Query: 509 QLSELRAQVEDLQKALQEQGGKTEDAISILLKRKLEEHLQKLH-EADLELQRKREYIEEL 567
Q+ E+R Q+E+L+ LQ TEDA K +LE ++Q + + + +LQ + E EE
Sbjct: 1540 QVEEMRTQLEELEDELQ----ATEDA-----KLRLEVNMQAMKAQFERDLQTRDEQNEEK 1590
Query: 568 EPPTDSSTARRIEELQHNLQ-KKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPP 626
+ +++ EL+ L+ ++ A+ + + +D + Q +E +
Sbjct: 1591 K----RLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQ-IEAANKARDEVIK 1645
Query: 627 ELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAH 686
+L L+ Q+++ + ++ +Q ++ EK L S + ++ A ERA H
Sbjct: 1646 QLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRH 1705
Query: 687 AQSFLAQQRLATNSRRGPLGRLASLN 712
A+ + LA G+ A L+
Sbjct: 1706 AEQ--ERDELADEITNSASGKSALLD 1729
Score = 80.5 bits (197), Expect = 5e-15
Identities = 112/525 (21%), Positives = 231/525 (44%), Gaps = 76/525 (14%)
Query: 200 QLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQSQL--EQLQEENFRLES 257
Q+ EE Q+ +E ++E+ + EGE + LL + + EQLQ E L +
Sbjct: 846 QVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAET-ELFA 904
Query: 258 GREDERLRCAELEREVAELQH-----------RNQALTSLAQEAQA----LKDEMDELRQ 302
E+ R R A ++E+ E+ H RNQ L + ++ QA L++++DE +
Sbjct: 905 EAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDE-EE 963
Query: 303 SSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRAQL 362
+ + QLE + ++++ ++ LE++N+ + + +ED + S A+
Sbjct: 964 GARQKLQLEKVTAEAK-----IKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEE 1018
Query: 363 EAQRRQVQELQGQR-------QEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLR 415
E + + + +++ ++ +E K EK E + K + T + + +AE L+
Sbjct: 1019 EEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAE---LQ 1075
Query: 416 EANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQ--LENKRLCR 473
+EL+ + Q + T N A +++ EL+ + LQ E+++ R
Sbjct: 1076 AQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVV-RELQAQIAELQEDFESEKASR 1134
Query: 474 QEAADRERQ-----EELQRHLEDANRARHGLETQHRLNQQQLSELR-----------AQV 517
+A ++R E L+ LED + +Q+++EL+ AQ+
Sbjct: 1135 NKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQI 1194
Query: 518 EDLQK----ALQEQGGKTEDAISILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDS 573
+D+++ AL+E + E A K LE++ Q L + EL + + +++++ ++
Sbjct: 1195 QDMRQRHATALEELSEQLEQAKR--FKANLEKNKQGLETDNKELACEVKVLQQVKAESEH 1252
Query: 574 STAR---RIEELQHNLQKKD---ADLRAMEERYRRYVDKARMVMQTMEPK----QRPAAG 623
+ +++EL + + D +L + + +D +++ E K + AA
Sbjct: 1253 KRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAAS 1312
Query: 624 APPELHSLRTQLRER-------DVRIRHLEMDFEKSRSQREQEEK 661
+L + L+E RIR LE + + Q+E+EE+
Sbjct: 1313 LESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEE 1357
Score = 79.3 bits (194), Expect = 1e-14
Identities = 115/470 (24%), Positives = 200/470 (42%), Gaps = 78/470 (16%)
Query: 236 KKLLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKD 295
K LL + Q E+LQ ++ L +E + ++E E+ E++ ++Q L +E L +
Sbjct: 842 KPLLQVTRQEEELQAKDEELLKVKEKQ----TKVEGELEEMERKHQ---QLLEEKNILAE 894
Query: 296 EMDELRQSSERAGQLEATLTSCRRRLGE-LRELRRQVRQLEERNAGHAERTRQLEDELRR 354
++ + A ++ A L + ++ L E L +L +V + EERN ++++ ++
Sbjct: 895 QLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQ- 953
Query: 355 AGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERL------- 407
L QL+ + Q+LQ ++ K +K E LE++ KEK+ +
Sbjct: 954 --DLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAEC 1011
Query: 408 ---LAERDS---------------LREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLA 449
LAE + + + E L+ + + L +A LD +T + +
Sbjct: 1012 SSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQI 1071
Query: 450 AEILPAELRETLLRLQLENKRLCRQEAADRERQE-------------------ELQRHLE 490
AE L A++ E L+LQL K Q A R E ELQ E
Sbjct: 1072 AE-LQAQIDE--LKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFE 1128
Query: 491 DANRARHGLETQHRLNQQQLSELRAQVE---DLQKALQEQGGKTEDAISILLKRKLEEHL 547
+R+ E Q R ++L L+ ++E D A QE K E ++ LK+ LEE
Sbjct: 1129 SEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVA-ELKKALEEE- 1186
Query: 548 QKLHEADLELQRKRE--YIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVD 605
K HEA ++ R+R +EEL S + + + NL+K L + V
Sbjct: 1187 TKNHEAQIQDMRQRHATALEEL-----SEQLEQAKRFKANLEKNKQGLETDNKELACEVK 1241
Query: 606 KARMVMQTMEPKQRPAAGAPPELHS-------LRTQLRERDVRIRHLEMD 648
+ V E K++ ELH+ LR +L E+ ++++ E+D
Sbjct: 1242 VLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQN-ELD 1290
Score = 65.5 bits (158), Expect = 2e-10
Identities = 91/407 (22%), Positives = 163/407 (40%), Gaps = 54/407 (13%)
Query: 183 EAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQ 242
EAE DE +QR L + + + + K AQ A + R K+L LQ
Sbjct: 1602 EAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKAR----------DEVIKQLRKLQ 1651
Query: 243 SQLEQLQEENFRLESGREDERLRCAELEREV----AELQHRNQALTSLAQEAQALKDEMD 298
+Q++ Q E + R++ + E E+++ AE+ + L S + + + E D
Sbjct: 1652 AQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERD 1711
Query: 299 ELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRA--- 355
EL + ++ L L E R L ++ QLEE L D R+
Sbjct: 1712 ELADEITNSASGKSAL------LDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQ 1765
Query: 356 -GSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLE----EKYESVTKEKERLLAE 410
+L A+L A+R Q+ RQ+ + ++ + + LE K+++ E + +
Sbjct: 1766 VDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQ 1825
Query: 411 RDSLREANEELRCA-----QLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQ 465
+ E + R A + + L + ++ D ++ A R L+ Q
Sbjct: 1826 LEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQ 1885
Query: 466 LENKRLCRQEAADRER--QEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKA 523
LE +E A R + +LQR L+DA A GL +++S L+ ++
Sbjct: 1886 LEEA----EEEATRANASRRKLQRELDDATEANEGL-------SREVSTLKNRL------ 1928
Query: 524 LQEQGGKTEDAISILLKRKLEEHLQKLHEADLELQRKREYIEELEPP 570
+GG + S +R+L L +D + + K + E +PP
Sbjct: 1929 --RRGGPISFSSSRSGRRQLHLEGASLELSDDDTESKTSDVNETQPP 1973
Score = 62.0 bits (149), Expect = 2e-09
Identities = 83/391 (21%), Positives = 170/391 (43%), Gaps = 73/391 (18%)
Query: 283 LTSLAQEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHA 342
L + ++ + L+ + +EL + E+ ++E GEL E+ R+ +QL E A
Sbjct: 844 LLQVTRQEEELQAKDEELLKVKEKQTKVE----------GELEEMERKHQQLLEEKNILA 893
Query: 343 ERTRQLEDELRRAGSLRAQLEAQRRQVQE----LQGQRQEEAMKAEKWLFECRNLEEKYE 398
E+ + + A +RA+L A++++++E L+ + +EE EE+ +
Sbjct: 894 EQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEE--------------EERNQ 939
Query: 399 SVTKEKERLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELR 458
+ EK+++ A L E +E A+ ++ + AE ++
Sbjct: 940 ILQNEKKKMQAHIQDLEEQLDEEEGAR---------------QKLQLEKVTAEAKIKKME 984
Query: 459 ETLLRLQLENKRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQV- 517
E +L L+ +N + +++ +R E L + L + +S+L ++
Sbjct: 985 EEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLK 1044
Query: 518 ------EDLQKALQEQGGKTEDAISILLKRKLEEHLQKLHEADLELQRKREYIEELEPPT 571
++L+KA ++ G+T D L+ ++ E ++ E L+L +K E ++
Sbjct: 1045 KEEKTRQELEKAKRKLDGETTD-----LQDQIAELQAQIDELKLQLAKKEEELQGALARG 1099
Query: 572 DSSTARRIEELQ--HNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELH 629
D T + L+ LQ + A+L+ E + +KA E ++R + EL
Sbjct: 1100 DDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKA-------EKQKRDLS---EELE 1149
Query: 630 SLRTQLRER-DVRIRHLEMDFEKSRSQREQE 659
+L+T+L + D E+ R++REQE
Sbjct: 1150 ALKTELEDTLDTTAAQQEL-----RTKREQE 1175
Score = 33.9 bits (76), Expect = 0.54
Identities = 44/190 (23%), Positives = 90/190 (47%), Gaps = 23/190 (12%)
Query: 508 QQLSELRAQVEDLQKALQEQGGKTEDAISILLKRKLEEHLQKLHEADLELQRKREYIEEL 567
+Q EL+A+ E+L K ++Q K E + + +RK ++ L++ + +LQ + E E
Sbjct: 849 RQEEELQAKDEELLKVKEKQT-KVEGELEEM-ERKHQQLLEEKNILAEQLQAETELFAEA 906
Query: 568 EPPTDSSTARR--IEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAP 625
E A++ +EE+ H+L+ R EE R ++Q + K +
Sbjct: 907 EEMRARLAAKKQELEEILHDLES-----RVEEEEER------NQILQNEKKKMQ------ 949
Query: 626 PELHSLRTQLRERDVRIRHLEMDFEKSRSQ-REQEEKLLISAWYNMGMALQQRAGEERAP 684
+ L QL E + + L+++ + ++ ++ EE++L+ N +++ E+R
Sbjct: 950 AHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRI- 1008
Query: 685 AHAQSFLAQQ 694
A S LA++
Sbjct: 1009 AECSSQLAEE 1018
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 89.4 bits (220), Expect = 1e-17
Identities = 134/563 (23%), Positives = 241/563 (42%), Gaps = 71/563 (12%)
Query: 182 EEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLL 241
+ A+ +EL ++ +R L + KQ+L +ENA L + R G+ + KK L
Sbjct: 1200 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGEL-RVLGQAKQEVEHKKKKL- 1257
Query: 242 QSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQ--ALKDEMDE 299
++Q+++LQ + + ER R AEL +V +LQ+ +++T + EA+ A+K D
Sbjct: 1258 EAQVQELQSKC------SDGERAR-AELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1310
Query: 300 LRQSSERAGQLEATLTSCRRRLG---ELRELRRQVRQLEERNAGHAERTRQLEDELRRAG 356
SS+ E R++L +LR+L + L+++ E + LE R
Sbjct: 1311 ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE---RHIS 1367
Query: 357 SLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYES-------VTKEKERLLA 409
+L QL ++++Q+ + +++ E NL ++YE + K K RL
Sbjct: 1368 TLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQ 1427
Query: 410 ERDSL-------REANEELRCAQLQPRGLTQADPSLDPT-STPVDNLAAEILPAELRETL 461
E D L R+ L Q + L + ++ + D AE E +
Sbjct: 1428 ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALS 1487
Query: 462 LRLQLENKRLCRQEAADRERQ-----EELQRHLEDANRARHGLETQHRLNQQQLSELRAQ 516
L LE ++E + E+L +D + H LE R + Q+ E++ Q
Sbjct: 1488 LARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ 1547
Query: 517 VEDLQKALQEQGGKTEDAISILLKRKLEEHLQKLH-EADLELQRKREYIEELEPPTDSST 575
+E+L+ LQ TEDA K +LE ++Q L + + +LQ + E EE
Sbjct: 1548 LEELEDELQ----ATEDA-----KLRLEVNMQALKGQFERDLQARDEQNEE--------- 1589
Query: 576 ARRIEELQHNLQKKDADLRAMEERYRRYVDKA--RMVMQTMEPKQRPAAGAPPELHSLRT 633
+ +LQ L + + +L +ER +R + A + + ++ + A A
Sbjct: 1590 --KRRQLQRQLHEYETELE--DERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIK 1645
Query: 634 QLRERDVRIRHLEMDFEKSRSQRE-------QEEKLLISAWYNMGMALQQRAGEERAPAH 686
QLR+ +++ + + E +R+ R+ + EK S ++ + A ER A
Sbjct: 1646 QLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAER--AR 1703
Query: 687 AQSFLAQQRLATNSRRGPLGRLA 709
Q+ L ++ LA GR A
Sbjct: 1704 KQADLEKEELAEELASSLSGRNA 1726
Score = 69.7 bits (169), Expect = 9e-12
Identities = 115/517 (22%), Positives = 223/517 (43%), Gaps = 84/517 (16%)
Query: 189 ELQQRCLDLERQLMLLS--EEKQS-----LAQE-NAGLRERMGRPEGEGTPGLTAKKLLL 240
EL +DL+ Q L+S E+KQ LA+E N + R E K L
Sbjct: 1428 ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALS 1487
Query: 241 LQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDEL 300
L LE+ E LE R ++ L+ AE+E V+ + + L + +AL+ +M+E+
Sbjct: 1488 LARALEEALEAKEELE--RTNKMLK-AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEM 1544
Query: 301 R-QSSERAGQLEATLTSCRRRLGELRELRRQV-RQLEERNAGHAERTRQLEDELRRAGSL 358
+ Q E +L+AT + R ++ L+ Q R L+ R+ + E+ RQL+ +L
Sbjct: 1545 KTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE---Y 1601
Query: 359 RAQLEAQRRQ-------VQELQGQRQEEAMKA-------EKWLFECRNLEEKYESVTKEK 404
+LE +R+Q ++L+G ++ ++A E+ + + R L+ + + +E
Sbjct: 1602 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1661
Query: 405 ERLLAERDSL---REANE------ELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPA 455
E A RD + + NE E QLQ L A+ + + LA E+ +
Sbjct: 1662 EDARASRDEIFATAKENEKKAKSLEADLMQLQ-EDLAAAERARKQADLEKEELAEELASS 1720
Query: 456 --------------ELRETLLRLQLENKRLCRQEAADRERQ-----EELQRHLEDANRAR 496
E R L +LE ++ + +DR R+ E+L L
Sbjct: 1721 LSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTA 1780
Query: 497 HGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDAISILL----------------- 539
E+ + ++Q ELR+++ +++ A++ + T A+ +
Sbjct: 1781 QKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAA 1840
Query: 540 KRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEER 599
+ L++ +KL E L+++ +R+ E+ + + A R+++L+ L++ EE
Sbjct: 1841 TKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNA-RVKQLKRQLEE-------AEEE 1892
Query: 600 YRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLR 636
+R R + + ++ E+++L+++LR
Sbjct: 1893 SQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1929
Score = 67.8 bits (164), Expect = 3e-11
Identities = 86/366 (23%), Positives = 152/366 (41%), Gaps = 37/366 (10%)
Query: 319 RRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRAQLEAQRRQVQELQGQRQE 378
R +++ L + RQ EE A E + E + + L+ +LE + Q+ E + QE
Sbjct: 836 RLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQE 894
Query: 379 EAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEELRCAQLQPRGLTQADPSL 438
+ + E + + + +E E +L E ++ R EE R QLQ A L
Sbjct: 895 QLQAETELYAEAEEMRVRLAAKKQELEEILHEMEA-RLEEEEDRGQQLQAERKKMAQQML 953
Query: 439 D-----------PTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQEAADRERQEELQR 487
D ++ + AE +L + +L + +N +L ++ ER +L
Sbjct: 954 DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT 1013
Query: 488 HLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDAISILLKRKLEEHL 547
+L + L ++ +SEL +++ +K+ QE LKRKLE
Sbjct: 1014 NLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE---------KLKRKLEGDA 1064
Query: 548 QKLHE--ADLELQ--RKREYIEELEPPTDSSTARRIEEL--QHNLQKKDADLRAMEERYR 601
HE ADL+ Q + + + E ++ AR +E+ ++N KK +L +
Sbjct: 1065 SDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQ 1124
Query: 602 RYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRER-DVRIRHLEMDFEKSRSQREQEE 660
+D R E ++R EL +L+T+L + D E+ R++REQE
Sbjct: 1125 EDLDSERAARNKAEKQKRDLG---EELEALKTELEDTLDSTATQQEL-----RAKREQEV 1176
Query: 661 KLLISA 666
+L A
Sbjct: 1177 TVLKKA 1182
Score = 65.1 bits (157), Expect = 2e-10
Identities = 103/514 (20%), Positives = 207/514 (40%), Gaps = 80/514 (15%)
Query: 180 LSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLL 239
L + E + + +LE++ L+EEK L ++ E E E L AKK
Sbjct: 861 LQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAE-EMRVRLAAKK-- 917
Query: 240 LLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDE 299
++L+E +E+ E+E R +L+ E +AQ+ L+++++E
Sbjct: 918 ------QELEEILHEMEARLEEEEDRGQQLQAE----------RKKMAQQMLDLEEQLEE 961
Query: 300 LRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLR 359
E RQ QLE+ A + ++LEDE+
Sbjct: 962 -------------------------EEAARQKLQLEKVTA--EAKIKKLEDEILVMDDQN 994
Query: 360 AQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANE 419
+L +R+ ++E + E+ L+ K+ES+ E E L + + R+ E
Sbjct: 995 NKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE 1054
Query: 420 ELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQEAADR 479
+L+ + + + + L ++ E +L+++ + A +
Sbjct: 1055 KLK--RKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKK 1112
Query: 480 ERQ-----EELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKAL---QEQGGKT 531
R+ +LQ L+ AR+ E Q R ++L L+ ++ED + QE K
Sbjct: 1113 IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR 1172
Query: 532 EDAISILLKRKLEEHLQKLHEADLELQRKR--EYIEELEPPTD--SSTARRIEELQHNLQ 587
E +++ LK+ L+E + HEA ++ R++ + +EEL + +++ + L+
Sbjct: 1173 EQEVTV-LKKALDEETRS-HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLE 1230
Query: 588 KKDADL-----------RAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQ-- 634
K++ADL + +E + ++ + + + +R A ++H L+ +
Sbjct: 1231 KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVE 1290
Query: 635 -----LRERDVRIRHLEMDFEKSRSQREQEEKLL 663
L E + + L D SQ + ++LL
Sbjct: 1291 SVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELL 1324
Score = 38.5 bits (88), Expect = 0.022
Identities = 54/229 (23%), Positives = 103/229 (44%), Gaps = 24/229 (10%)
Query: 134 RIMTLEESVQHVV--MEAIQELMTKDTP--DSLSPETYGNFDSQSRRYYFLSEEAEEGDE 189
RI LEE ++ MEA+ + + K T + LS E + + + + E
Sbjct: 1737 RIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKE 1796
Query: 190 LQQRCLDLERQLMLLSEEKQSLAQENAGLR------ERMGRPEGEGTPGLTAK----KLL 239
L+ + ++E + S+ K ++A A + E+ R + T L K K +
Sbjct: 1797 LRSKLHEMEGAVK--SKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEI 1854
Query: 240 LLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDE 299
LLQ + E+ E ++ ++ + + R++ +L+R++ E + +Q + + + L+ E+DE
Sbjct: 1855 LLQVEDERKMAEQYKEQAEKGNARVK--QLKRQLEEAEEESQRINA---NRRKLQRELDE 1909
Query: 300 LRQSSERAGQLEATLTSCRRRLGE---LRELRRQVRQLEERNAGHAERT 345
+S+E G+ L S RR E + R R++ E G E T
Sbjct: 1910 ATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENADGSEEET 1958
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 89.4 bits (220), Expect = 1e-17
Identities = 134/563 (23%), Positives = 241/563 (42%), Gaps = 71/563 (12%)
Query: 182 EEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLL 241
+ A+ +EL ++ +R L + KQ+L +ENA L + R G+ + KK L
Sbjct: 1207 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGEL-RVLGQAKQEVEHKKKKL- 1264
Query: 242 QSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQ--ALKDEMDE 299
++Q+++LQ + + ER R AEL +V +LQ+ +++T + EA+ A+K D
Sbjct: 1265 EAQVQELQSKC------SDGERAR-AELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1317
Query: 300 LRQSSERAGQLEATLTSCRRRLG---ELRELRRQVRQLEERNAGHAERTRQLEDELRRAG 356
SS+ E R++L +LR+L + L+++ E + LE R
Sbjct: 1318 ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE---RHIS 1374
Query: 357 SLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYES-------VTKEKERLLA 409
+L QL ++++Q+ + +++ E NL ++YE + K K RL
Sbjct: 1375 TLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQ 1434
Query: 410 ERDSL-------REANEELRCAQLQPRGLTQADPSLDPT-STPVDNLAAEILPAELRETL 461
E D L R+ L Q + L + ++ + D AE E +
Sbjct: 1435 ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALS 1494
Query: 462 LRLQLENKRLCRQEAADRERQ-----EELQRHLEDANRARHGLETQHRLNQQQLSELRAQ 516
L LE ++E + E+L +D + H LE R + Q+ E++ Q
Sbjct: 1495 LARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ 1554
Query: 517 VEDLQKALQEQGGKTEDAISILLKRKLEEHLQKLH-EADLELQRKREYIEELEPPTDSST 575
+E+L+ LQ TEDA K +LE ++Q L + + +LQ + E EE
Sbjct: 1555 LEELEDELQ----ATEDA-----KLRLEVNMQALKGQFERDLQARDEQNEE--------- 1596
Query: 576 ARRIEELQHNLQKKDADLRAMEERYRRYVDKA--RMVMQTMEPKQRPAAGAPPELHSLRT 633
+ +LQ L + + +L +ER +R + A + + ++ + A A
Sbjct: 1597 --KRRQLQRQLHEYETELE--DERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIK 1652
Query: 634 QLRERDVRIRHLEMDFEKSRSQRE-------QEEKLLISAWYNMGMALQQRAGEERAPAH 686
QLR+ +++ + + E +R+ R+ + EK S ++ + A ER A
Sbjct: 1653 QLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAER--AR 1710
Query: 687 AQSFLAQQRLATNSRRGPLGRLA 709
Q+ L ++ LA GR A
Sbjct: 1711 KQADLEKEELAEELASSLSGRNA 1733
Score = 69.7 bits (169), Expect = 9e-12
Identities = 115/517 (22%), Positives = 223/517 (43%), Gaps = 84/517 (16%)
Query: 189 ELQQRCLDLERQLMLLS--EEKQS-----LAQE-NAGLRERMGRPEGEGTPGLTAKKLLL 240
EL +DL+ Q L+S E+KQ LA+E N + R E K L
Sbjct: 1435 ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALS 1494
Query: 241 LQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDEL 300
L LE+ E LE R ++ L+ AE+E V+ + + L + +AL+ +M+E+
Sbjct: 1495 LARALEEALEAKEELE--RTNKMLK-AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEM 1551
Query: 301 R-QSSERAGQLEATLTSCRRRLGELRELRRQV-RQLEERNAGHAERTRQLEDELRRAGSL 358
+ Q E +L+AT + R ++ L+ Q R L+ R+ + E+ RQL+ +L
Sbjct: 1552 KTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE---Y 1608
Query: 359 RAQLEAQRRQ-------VQELQGQRQEEAMKA-------EKWLFECRNLEEKYESVTKEK 404
+LE +R+Q ++L+G ++ ++A E+ + + R L+ + + +E
Sbjct: 1609 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1668
Query: 405 ERLLAERDSL---REANE------ELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPA 455
E A RD + + NE E QLQ L A+ + + LA E+ +
Sbjct: 1669 EDARASRDEIFATAKENEKKAKSLEADLMQLQ-EDLAAAERARKQADLEKEELAEELASS 1727
Query: 456 --------------ELRETLLRLQLENKRLCRQEAADRERQ-----EELQRHLEDANRAR 496
E R L +LE ++ + +DR R+ E+L L
Sbjct: 1728 LSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTA 1787
Query: 497 HGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDAISILL----------------- 539
E+ + ++Q ELR+++ +++ A++ + T A+ +
Sbjct: 1788 QKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAA 1847
Query: 540 KRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEER 599
+ L++ +KL E L+++ +R+ E+ + + A R+++L+ L++ EE
Sbjct: 1848 TKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNA-RVKQLKRQLEE-------AEEE 1899
Query: 600 YRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLR 636
+R R + + ++ E+++L+++LR
Sbjct: 1900 SQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1936
Score = 67.8 bits (164), Expect = 3e-11
Identities = 86/366 (23%), Positives = 152/366 (41%), Gaps = 37/366 (10%)
Query: 319 RRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRAQLEAQRRQVQELQGQRQE 378
R +++ L + RQ EE A E + E + + L+ +LE + Q+ E + QE
Sbjct: 843 RLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQE 901
Query: 379 EAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEELRCAQLQPRGLTQADPSL 438
+ + E + + + +E E +L E ++ R EE R QLQ A L
Sbjct: 902 QLQAETELYAEAEEMRVRLAAKKQELEEILHEMEA-RLEEEEDRGQQLQAERKKMAQQML 960
Query: 439 D-----------PTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQEAADRERQEELQR 487
D ++ + AE +L + +L + +N +L ++ ER +L
Sbjct: 961 DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT 1020
Query: 488 HLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDAISILLKRKLEEHL 547
+L + L ++ +SEL +++ +K+ QE LKRKLE
Sbjct: 1021 NLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE---------KLKRKLEGDA 1071
Query: 548 QKLHE--ADLELQ--RKREYIEELEPPTDSSTARRIEEL--QHNLQKKDADLRAMEERYR 601
HE ADL+ Q + + + E ++ AR +E+ ++N KK +L +
Sbjct: 1072 SDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQ 1131
Query: 602 RYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRER-DVRIRHLEMDFEKSRSQREQEE 660
+D R E ++R EL +L+T+L + D E+ R++REQE
Sbjct: 1132 EDLDSERAARNKAEKQKRDLG---EELEALKTELEDTLDSTATQQEL-----RAKREQEV 1183
Query: 661 KLLISA 666
+L A
Sbjct: 1184 TVLKKA 1189
Score = 65.1 bits (157), Expect = 2e-10
Identities = 103/514 (20%), Positives = 207/514 (40%), Gaps = 80/514 (15%)
Query: 180 LSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLL 239
L + E + + +LE++ L+EEK L ++ E E E L AKK
Sbjct: 868 LQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAE-EMRVRLAAKK-- 924
Query: 240 LLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDE 299
++L+E +E+ E+E R +L+ E +AQ+ L+++++E
Sbjct: 925 ------QELEEILHEMEARLEEEEDRGQQLQAE----------RKKMAQQMLDLEEQLEE 968
Query: 300 LRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLR 359
E RQ QLE+ A + ++LEDE+
Sbjct: 969 -------------------------EEAARQKLQLEKVTA--EAKIKKLEDEILVMDDQN 1001
Query: 360 AQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANE 419
+L +R+ ++E + E+ L+ K+ES+ E E L + + R+ E
Sbjct: 1002 NKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE 1061
Query: 420 ELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQEAADR 479
+L+ + + + + L ++ E +L+++ + A +
Sbjct: 1062 KLK--RKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKK 1119
Query: 480 ERQ-----EELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKAL---QEQGGKT 531
R+ +LQ L+ AR+ E Q R ++L L+ ++ED + QE K
Sbjct: 1120 IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR 1179
Query: 532 EDAISILLKRKLEEHLQKLHEADLELQRKR--EYIEELEPPTD--SSTARRIEELQHNLQ 587
E +++ LK+ L+E + HEA ++ R++ + +EEL + +++ + L+
Sbjct: 1180 EQEVTV-LKKALDEETRS-HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLE 1237
Query: 588 KKDADL-----------RAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQ-- 634
K++ADL + +E + ++ + + + +R A ++H L+ +
Sbjct: 1238 KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVE 1297
Query: 635 -----LRERDVRIRHLEMDFEKSRSQREQEEKLL 663
L E + + L D SQ + ++LL
Sbjct: 1298 SVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELL 1331
Score = 38.5 bits (88), Expect = 0.022
Identities = 54/229 (23%), Positives = 103/229 (44%), Gaps = 24/229 (10%)
Query: 134 RIMTLEESVQHVV--MEAIQELMTKDTP--DSLSPETYGNFDSQSRRYYFLSEEAEEGDE 189
RI LEE ++ MEA+ + + K T + LS E + + + + E
Sbjct: 1744 RIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKE 1803
Query: 190 LQQRCLDLERQLMLLSEEKQSLAQENAGLR------ERMGRPEGEGTPGLTAK----KLL 239
L+ + ++E + S+ K ++A A + E+ R + T L K K +
Sbjct: 1804 LRSKLHEMEGAVK--SKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEI 1861
Query: 240 LLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDE 299
LLQ + E+ E ++ ++ + + R++ +L+R++ E + +Q + + + L+ E+DE
Sbjct: 1862 LLQVEDERKMAEQYKEQAEKGNARVK--QLKRQLEEAEEESQRINA---NRRKLQRELDE 1916
Query: 300 LRQSSERAGQLEATLTSCRRRLGE---LRELRRQVRQLEERNAGHAERT 345
+S+E G+ L S RR E + R R++ E G E T
Sbjct: 1917 ATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENADGSEEET 1965
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 89.4 bits (220), Expect = 1e-17
Identities = 134/563 (23%), Positives = 241/563 (42%), Gaps = 71/563 (12%)
Query: 182 EEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLL 241
+ A+ +EL ++ +R L + KQ+L +ENA L + R G+ + KK L
Sbjct: 1207 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGEL-RVLGQAKQEVEHKKKKL- 1264
Query: 242 QSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQ--ALKDEMDE 299
++Q+++LQ + + ER R AEL +V +LQ+ +++T + EA+ A+K D
Sbjct: 1265 EAQVQELQSKC------SDGERAR-AELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1317
Query: 300 LRQSSERAGQLEATLTSCRRRLG---ELRELRRQVRQLEERNAGHAERTRQLEDELRRAG 356
SS+ E R++L +LR+L + L+++ E + LE R
Sbjct: 1318 ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE---RHIS 1374
Query: 357 SLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYES-------VTKEKERLLA 409
+L QL ++++Q+ + +++ E NL ++YE + K K RL
Sbjct: 1375 TLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQ 1434
Query: 410 ERDSL-------REANEELRCAQLQPRGLTQADPSLDPT-STPVDNLAAEILPAELRETL 461
E D L R+ L Q + L + ++ + D AE E +
Sbjct: 1435 ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALS 1494
Query: 462 LRLQLENKRLCRQEAADRERQ-----EELQRHLEDANRARHGLETQHRLNQQQLSELRAQ 516
L LE ++E + E+L +D + H LE R + Q+ E++ Q
Sbjct: 1495 LARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ 1554
Query: 517 VEDLQKALQEQGGKTEDAISILLKRKLEEHLQKLH-EADLELQRKREYIEELEPPTDSST 575
+E+L+ LQ TEDA K +LE ++Q L + + +LQ + E EE
Sbjct: 1555 LEELEDELQ----ATEDA-----KLRLEVNMQALKGQFERDLQARDEQNEE--------- 1596
Query: 576 ARRIEELQHNLQKKDADLRAMEERYRRYVDKA--RMVMQTMEPKQRPAAGAPPELHSLRT 633
+ +LQ L + + +L +ER +R + A + + ++ + A A
Sbjct: 1597 --KRRQLQRQLHEYETELE--DERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIK 1652
Query: 634 QLRERDVRIRHLEMDFEKSRSQRE-------QEEKLLISAWYNMGMALQQRAGEERAPAH 686
QLR+ +++ + + E +R+ R+ + EK S ++ + A ER A
Sbjct: 1653 QLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAER--AR 1710
Query: 687 AQSFLAQQRLATNSRRGPLGRLA 709
Q+ L ++ LA GR A
Sbjct: 1711 KQADLEKEELAEELASSLSGRNA 1733
Score = 70.9 bits (172), Expect = 4e-12
Identities = 113/514 (21%), Positives = 218/514 (42%), Gaps = 82/514 (15%)
Query: 189 ELQQRCLDLERQLMLLS--EEKQS-----LAQE-NAGLRERMGRPEGEGTPGLTAKKLLL 240
EL +DL+ Q L+S E+KQ LA+E N + R E K L
Sbjct: 1435 ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALS 1494
Query: 241 LQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDEL 300
L LE+ E LE R ++ L+ AE+E V+ + + L + +AL+ +M+E+
Sbjct: 1495 LARALEEALEAKEELE--RTNKMLK-AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEM 1551
Query: 301 R-QSSERAGQLEATLTSCRRRLGELRELRRQV-RQLEERNAGHAERTRQLEDELRRAGSL 358
+ Q E +L+AT + R ++ L+ Q R L+ R+ + E+ RQL+ +L
Sbjct: 1552 KTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE---Y 1608
Query: 359 RAQLEAQRRQ-------VQELQGQRQEEAMKA-------EKWLFECRNLEEKYESVTKEK 404
+LE +R+Q ++L+G ++ ++A E+ + + R L+ + + +E
Sbjct: 1609 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1668
Query: 405 ERLLAERDSL---REANE------ELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPA 455
E A RD + + NE E QLQ L A+ + + LA E+ +
Sbjct: 1669 EDARASRDEIFATAKENEKKAKSLEADLMQLQ-EDLAAAERARKQADLEKEELAEELASS 1727
Query: 456 --------------ELRETLLRLQLENKRLCRQEAADRERQ-----EELQRHLEDANRAR 496
E R L +LE ++ + +DR R+ E+L L
Sbjct: 1728 LSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTA 1787
Query: 497 HGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDAISILL----------------- 539
E+ + ++Q ELR+++ +++ A++ + T A+ +
Sbjct: 1788 QKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAA 1847
Query: 540 KRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTA------RRIEELQHNLQKKDADL 593
+ L++ +KL E L+++ +R+ E+ + + A R++EE + Q+ +A+
Sbjct: 1848 TKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANR 1907
Query: 594 RAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPE 627
R ++ + + + + + G PP+
Sbjct: 1908 RKLQRELDEATESNEAMGREVNALKSKLRGPPPQ 1941
Score = 67.8 bits (164), Expect = 3e-11
Identities = 86/366 (23%), Positives = 152/366 (41%), Gaps = 37/366 (10%)
Query: 319 RRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRAQLEAQRRQVQELQGQRQE 378
R +++ L + RQ EE A E + E + + L+ +LE + Q+ E + QE
Sbjct: 843 RLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQE 901
Query: 379 EAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEELRCAQLQPRGLTQADPSL 438
+ + E + + + +E E +L E ++ R EE R QLQ A L
Sbjct: 902 QLQAETELYAEAEEMRVRLAAKKQELEEILHEMEA-RLEEEEDRGQQLQAERKKMAQQML 960
Query: 439 D-----------PTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQEAADRERQEELQR 487
D ++ + AE +L + +L + +N +L ++ ER +L
Sbjct: 961 DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT 1020
Query: 488 HLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDAISILLKRKLEEHL 547
+L + L ++ +SEL +++ +K+ QE LKRKLE
Sbjct: 1021 NLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE---------KLKRKLEGDA 1071
Query: 548 QKLHE--ADLELQ--RKREYIEELEPPTDSSTARRIEEL--QHNLQKKDADLRAMEERYR 601
HE ADL+ Q + + + E ++ AR +E+ ++N KK +L +
Sbjct: 1072 SDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQ 1131
Query: 602 RYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRER-DVRIRHLEMDFEKSRSQREQEE 660
+D R E ++R EL +L+T+L + D E+ R++REQE
Sbjct: 1132 EDLDSERAARNKAEKQKRDLG---EELEALKTELEDTLDSTATQQEL-----RAKREQEV 1183
Query: 661 KLLISA 666
+L A
Sbjct: 1184 TVLKKA 1189
Score = 65.1 bits (157), Expect = 2e-10
Identities = 103/514 (20%), Positives = 207/514 (40%), Gaps = 80/514 (15%)
Query: 180 LSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLL 239
L + E + + +LE++ L+EEK L ++ E E E L AKK
Sbjct: 868 LQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAE-EMRVRLAAKK-- 924
Query: 240 LLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDE 299
++L+E +E+ E+E R +L+ E +AQ+ L+++++E
Sbjct: 925 ------QELEEILHEMEARLEEEEDRGQQLQAE----------RKKMAQQMLDLEEQLEE 968
Query: 300 LRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLR 359
E RQ QLE+ A + ++LEDE+
Sbjct: 969 -------------------------EEAARQKLQLEKVTA--EAKIKKLEDEILVMDDQN 1001
Query: 360 AQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANE 419
+L +R+ ++E + E+ L+ K+ES+ E E L + + R+ E
Sbjct: 1002 NKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE 1061
Query: 420 ELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQEAADR 479
+L+ + + + + L ++ E +L+++ + A +
Sbjct: 1062 KLK--RKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKK 1119
Query: 480 ERQ-----EELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKAL---QEQGGKT 531
R+ +LQ L+ AR+ E Q R ++L L+ ++ED + QE K
Sbjct: 1120 IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR 1179
Query: 532 EDAISILLKRKLEEHLQKLHEADLELQRKR--EYIEELEPPTD--SSTARRIEELQHNLQ 587
E +++ LK+ L+E + HEA ++ R++ + +EEL + +++ + L+
Sbjct: 1180 EQEVTV-LKKALDEETRS-HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLE 1237
Query: 588 KKDADL-----------RAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQ-- 634
K++ADL + +E + ++ + + + +R A ++H L+ +
Sbjct: 1238 KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVE 1297
Query: 635 -----LRERDVRIRHLEMDFEKSRSQREQEEKLL 663
L E + + L D SQ + ++LL
Sbjct: 1298 SVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELL 1331
Score = 35.8 bits (81), Expect = 0.14
Identities = 43/190 (22%), Positives = 89/190 (46%), Gaps = 21/190 (11%)
Query: 134 RIMTLEESVQHVV--MEAIQELMTKDTP--DSLSPETYGNFDSQSRRYYFLSEEAEEGDE 189
RI LEE ++ MEA+ + + K T + LS E + + + + E
Sbjct: 1744 RIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKE 1803
Query: 190 LQQRCLDLERQLMLLSEEKQSLAQENAGLR------ERMGRPEGEGTPGLTAK----KLL 239
L+ + ++E + S+ K ++A A + E+ R + T L K K +
Sbjct: 1804 LRSKLHEMEGAVK--SKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEI 1861
Query: 240 LLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDE 299
LLQ + E+ E ++ ++ + + R++ +L+R++ E + +Q + + + L+ E+DE
Sbjct: 1862 LLQVEDERKMAEQYKEQAEKGNARVK--QLKRQLEEAEEESQRINA---NRRKLQRELDE 1916
Query: 300 LRQSSERAGQ 309
+S+E G+
Sbjct: 1917 ATESNEAMGR 1926
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 89.4 bits (220), Expect = 1e-17
Identities = 134/563 (23%), Positives = 241/563 (42%), Gaps = 71/563 (12%)
Query: 182 EEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLL 241
+ A+ +EL ++ +R L + KQ+L +ENA L + R G+ + KK L
Sbjct: 1200 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGEL-RVLGQAKQEVEHKKKKL- 1257
Query: 242 QSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQ--ALKDEMDE 299
++Q+++LQ + + ER R AEL +V +LQ+ +++T + EA+ A+K D
Sbjct: 1258 EAQVQELQSKC------SDGERAR-AELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1310
Query: 300 LRQSSERAGQLEATLTSCRRRLG---ELRELRRQVRQLEERNAGHAERTRQLEDELRRAG 356
SS+ E R++L +LR+L + L+++ E + LE R
Sbjct: 1311 ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE---RHIS 1367
Query: 357 SLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYES-------VTKEKERLLA 409
+L QL ++++Q+ + +++ E NL ++YE + K K RL
Sbjct: 1368 TLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQ 1427
Query: 410 ERDSL-------REANEELRCAQLQPRGLTQADPSLDPT-STPVDNLAAEILPAELRETL 461
E D L R+ L Q + L + ++ + D AE E +
Sbjct: 1428 ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALS 1487
Query: 462 LRLQLENKRLCRQEAADRERQ-----EELQRHLEDANRARHGLETQHRLNQQQLSELRAQ 516
L LE ++E + E+L +D + H LE R + Q+ E++ Q
Sbjct: 1488 LARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ 1547
Query: 517 VEDLQKALQEQGGKTEDAISILLKRKLEEHLQKLH-EADLELQRKREYIEELEPPTDSST 575
+E+L+ LQ TEDA K +LE ++Q L + + +LQ + E EE
Sbjct: 1548 LEELEDELQ----ATEDA-----KLRLEVNMQALKGQFERDLQARDEQNEE--------- 1589
Query: 576 ARRIEELQHNLQKKDADLRAMEERYRRYVDKA--RMVMQTMEPKQRPAAGAPPELHSLRT 633
+ +LQ L + + +L +ER +R + A + + ++ + A A
Sbjct: 1590 --KRRQLQRQLHEYETELE--DERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIK 1645
Query: 634 QLRERDVRIRHLEMDFEKSRSQRE-------QEEKLLISAWYNMGMALQQRAGEERAPAH 686
QLR+ +++ + + E +R+ R+ + EK S ++ + A ER A
Sbjct: 1646 QLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAER--AR 1703
Query: 687 AQSFLAQQRLATNSRRGPLGRLA 709
Q+ L ++ LA GR A
Sbjct: 1704 KQADLEKEELAEELASSLSGRNA 1726
Score = 70.9 bits (172), Expect = 4e-12
Identities = 113/514 (21%), Positives = 218/514 (42%), Gaps = 82/514 (15%)
Query: 189 ELQQRCLDLERQLMLLS--EEKQS-----LAQE-NAGLRERMGRPEGEGTPGLTAKKLLL 240
EL +DL+ Q L+S E+KQ LA+E N + R E K L
Sbjct: 1428 ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALS 1487
Query: 241 LQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDEL 300
L LE+ E LE R ++ L+ AE+E V+ + + L + +AL+ +M+E+
Sbjct: 1488 LARALEEALEAKEELE--RTNKMLK-AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEM 1544
Query: 301 R-QSSERAGQLEATLTSCRRRLGELRELRRQV-RQLEERNAGHAERTRQLEDELRRAGSL 358
+ Q E +L+AT + R ++ L+ Q R L+ R+ + E+ RQL+ +L
Sbjct: 1545 KTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE---Y 1601
Query: 359 RAQLEAQRRQ-------VQELQGQRQEEAMKA-------EKWLFECRNLEEKYESVTKEK 404
+LE +R+Q ++L+G ++ ++A E+ + + R L+ + + +E
Sbjct: 1602 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1661
Query: 405 ERLLAERDSL---REANE------ELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPA 455
E A RD + + NE E QLQ L A+ + + LA E+ +
Sbjct: 1662 EDARASRDEIFATAKENEKKAKSLEADLMQLQ-EDLAAAERARKQADLEKEELAEELASS 1720
Query: 456 --------------ELRETLLRLQLENKRLCRQEAADRERQ-----EELQRHLEDANRAR 496
E R L +LE ++ + +DR R+ E+L L
Sbjct: 1721 LSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTA 1780
Query: 497 HGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDAISILL----------------- 539
E+ + ++Q ELR+++ +++ A++ + T A+ +
Sbjct: 1781 QKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAA 1840
Query: 540 KRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTA------RRIEELQHNLQKKDADL 593
+ L++ +KL E L+++ +R+ E+ + + A R++EE + Q+ +A+
Sbjct: 1841 TKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANR 1900
Query: 594 RAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPE 627
R ++ + + + + + G PP+
Sbjct: 1901 RKLQRELDEATESNEAMGREVNALKSKLRGPPPQ 1934
Score = 67.8 bits (164), Expect = 3e-11
Identities = 86/366 (23%), Positives = 152/366 (41%), Gaps = 37/366 (10%)
Query: 319 RRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRAQLEAQRRQVQELQGQRQE 378
R +++ L + RQ EE A E + E + + L+ +LE + Q+ E + QE
Sbjct: 836 RLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQE 894
Query: 379 EAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEELRCAQLQPRGLTQADPSL 438
+ + E + + + +E E +L E ++ R EE R QLQ A L
Sbjct: 895 QLQAETELYAEAEEMRVRLAAKKQELEEILHEMEA-RLEEEEDRGQQLQAERKKMAQQML 953
Query: 439 D-----------PTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQEAADRERQEELQR 487
D ++ + AE +L + +L + +N +L ++ ER +L
Sbjct: 954 DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT 1013
Query: 488 HLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDAISILLKRKLEEHL 547
+L + L ++ +SEL +++ +K+ QE LKRKLE
Sbjct: 1014 NLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE---------KLKRKLEGDA 1064
Query: 548 QKLHE--ADLELQ--RKREYIEELEPPTDSSTARRIEEL--QHNLQKKDADLRAMEERYR 601
HE ADL+ Q + + + E ++ AR +E+ ++N KK +L +
Sbjct: 1065 SDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQ 1124
Query: 602 RYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRER-DVRIRHLEMDFEKSRSQREQEE 660
+D R E ++R EL +L+T+L + D E+ R++REQE
Sbjct: 1125 EDLDSERAARNKAEKQKRDLG---EELEALKTELEDTLDSTATQQEL-----RAKREQEV 1176
Query: 661 KLLISA 666
+L A
Sbjct: 1177 TVLKKA 1182
Score = 65.1 bits (157), Expect = 2e-10
Identities = 103/514 (20%), Positives = 207/514 (40%), Gaps = 80/514 (15%)
Query: 180 LSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLL 239
L + E + + +LE++ L+EEK L ++ E E E L AKK
Sbjct: 861 LQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAE-EMRVRLAAKK-- 917
Query: 240 LLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDE 299
++L+E +E+ E+E R +L+ E +AQ+ L+++++E
Sbjct: 918 ------QELEEILHEMEARLEEEEDRGQQLQAE----------RKKMAQQMLDLEEQLEE 961
Query: 300 LRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLR 359
E RQ QLE+ A + ++LEDE+
Sbjct: 962 -------------------------EEAARQKLQLEKVTA--EAKIKKLEDEILVMDDQN 994
Query: 360 AQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANE 419
+L +R+ ++E + E+ L+ K+ES+ E E L + + R+ E
Sbjct: 995 NKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE 1054
Query: 420 ELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQEAADR 479
+L+ + + + + L ++ E +L+++ + A +
Sbjct: 1055 KLK--RKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKK 1112
Query: 480 ERQ-----EELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKAL---QEQGGKT 531
R+ +LQ L+ AR+ E Q R ++L L+ ++ED + QE K
Sbjct: 1113 IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR 1172
Query: 532 EDAISILLKRKLEEHLQKLHEADLELQRKR--EYIEELEPPTD--SSTARRIEELQHNLQ 587
E +++ LK+ L+E + HEA ++ R++ + +EEL + +++ + L+
Sbjct: 1173 EQEVTV-LKKALDEETRS-HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLE 1230
Query: 588 KKDADL-----------RAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQ-- 634
K++ADL + +E + ++ + + + +R A ++H L+ +
Sbjct: 1231 KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVE 1290
Query: 635 -----LRERDVRIRHLEMDFEKSRSQREQEEKLL 663
L E + + L D SQ + ++LL
Sbjct: 1291 SVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELL 1324
Score = 35.8 bits (81), Expect = 0.14
Identities = 43/190 (22%), Positives = 89/190 (46%), Gaps = 21/190 (11%)
Query: 134 RIMTLEESVQHVV--MEAIQELMTKDTP--DSLSPETYGNFDSQSRRYYFLSEEAEEGDE 189
RI LEE ++ MEA+ + + K T + LS E + + + + E
Sbjct: 1737 RIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKE 1796
Query: 190 LQQRCLDLERQLMLLSEEKQSLAQENAGLR------ERMGRPEGEGTPGLTAK----KLL 239
L+ + ++E + S+ K ++A A + E+ R + T L K K +
Sbjct: 1797 LRSKLHEMEGAVK--SKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEI 1854
Query: 240 LLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDE 299
LLQ + E+ E ++ ++ + + R++ +L+R++ E + +Q + + + L+ E+DE
Sbjct: 1855 LLQVEDERKMAEQYKEQAEKGNARVK--QLKRQLEEAEEESQRINA---NRRKLQRELDE 1909
Query: 300 LRQSSERAGQ 309
+S+E G+
Sbjct: 1910 ATESNEAMGR 1919
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 88.2 bits (217), Expect = 2e-17
Identities = 113/586 (19%), Positives = 249/586 (42%), Gaps = 74/586 (12%)
Query: 141 SVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYFLSEEAEEGDELQQRCLDLERQ 200
S H + E +TK+ D+LS E Y N + +EL+++ +L+ +
Sbjct: 151 STWHKKADRYIEELTKER-DALSLELYRNTITN--------------EELKKKNAELQEK 195
Query: 201 LMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQSQLEQLQEENFRLESGRE 260
L L EK + L+ ++ R K LL Q Q LQEE +R E
Sbjct: 196 LRLAESEKSEIQLNVKELKRKLERA-----------KFLLPQVQTNTLQEEMWRQEEELR 244
Query: 261 DERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDELRQSSERAGQLEATLTSCRRR 320
++ + + E ++ + R L ++ ++++ +++R+ +R + E L +
Sbjct: 245 EQEKKIRKQEEKMWRQEER------LREQEGKMREQEEKMRRQEKRLREQEKELREQEKE 298
Query: 321 LGELRELRRQVRQLEERNAG---HAERTRQLEDEL-RRAGSLRAQLEAQRRQVQELQGQR 376
L E ++LR Q Q++E+ E+ R+ E+++ R+ L Q + R Q Q+++ Q
Sbjct: 299 LREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQE 358
Query: 377 Q------------EEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEELR-- 422
+ EE M+ ++ ++E ++ E + + ++++ E +++RE E+++
Sbjct: 359 ERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQ 418
Query: 423 ----CAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLE----NKRLCRQ 474
Q + Q P + + + +E +R Q E K++ RQ
Sbjct: 419 EENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQ 478
Query: 475 EAADRERQEEL---QRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKT 531
E RE+++++ + + D + E + ++L E ++ + +K Q++
Sbjct: 479 EKM-REQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMR 537
Query: 532 EDAISILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDA 591
E+ + ++K + +K+ E + +R+++ EE E + E + +Q+++
Sbjct: 538 EEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEE---------MMREQEEKMQEQEE 588
Query: 592 DLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPE--LHSLRTQLRERDVRIRHLEMD- 648
+R EE+ +K + + M ++ E + + E++ +++ E
Sbjct: 589 KMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKM 648
Query: 649 FEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQ 694
+E+ REQEEK+ G + R EE+ + Q+
Sbjct: 649 WEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQE 694
Score = 85.1 bits (209), Expect = 2e-16
Identities = 96/483 (19%), Positives = 213/483 (44%), Gaps = 31/483 (6%)
Query: 185 EEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQSQ 244
E+ EL+++ +L Q L +E+Q QE + E E ++L + Q
Sbjct: 287 EQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQ 346
Query: 245 LEQLQEENFRLESGR---EDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDELR 301
+ + QE+ R + R +DERLR E E + E Q + QE + +++ ++R
Sbjct: 347 MRE-QEQKMRDQEERMWEQDERLR--EKEERMRE-QEKMWEQEEKMQEEERIREREKKMR 402
Query: 302 QSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRAQ 361
+ E + E + + E E Q ++L E+ E+ + E E + +
Sbjct: 403 EEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIW-----E 457
Query: 362 LEAQRRQVQELQGQ-----RQEEAMKAEKWLFECRN-LEEKYESVTKEKERLLAERDSLR 415
E + R +E+ GQ RQE+ + E ++E + ++ + + ++ER+ + + LR
Sbjct: 458 QEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLR 517
Query: 416 EANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQE 475
E E +R Q + Q + + T ++RE R++ K++ +E
Sbjct: 518 EKEERMR---EQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEE-RMREREKKMREEE 573
Query: 476 AADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDAI 535
RE++E++Q E + Q Q+Q ++ Q E + + +E + ++ +
Sbjct: 574 EMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEM 633
Query: 536 SILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRA 595
+ K++E +K+ E + +++ + E + E E +++ + +++++ ++
Sbjct: 634 MWEQEEKMQEQEEKMWEQEEKMREQEEKMREQE--------EKMQGQEEKMREQEEKMQG 685
Query: 596 MEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQ 655
EE+ R +K R + M ++ G ++ + ++RE++ RIR + ++ +
Sbjct: 686 QEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWG-QEEMREKEERIRDQKEKMQERLPE 744
Query: 656 REQ 658
E+
Sbjct: 745 HEE 747
Score = 55.8 bits (133), Expect = 1e-07
Identities = 53/258 (20%), Positives = 121/258 (46%), Gaps = 16/258 (6%)
Query: 173 QSRRYYFLSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPG 232
Q R + E E +E + + +Q + EEK++ QE + E E
Sbjct: 505 QEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMRE 564
Query: 233 LTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQA 292
K ++ + E ++E+ +++ E R + ++ + ++Q + + + +E
Sbjct: 565 REKK----MREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWE-QEEKMW 619
Query: 293 LKDEMDELRQSSERAGQLEATLTSCRRRLGE----LRELRRQVRQLEERNAGHAERTRQL 348
++E D++++ E + E + ++ E +RE ++R+ EE+ G E+ R+
Sbjct: 620 EQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQ 679
Query: 349 EDELR-RAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERL 407
E++++ + +R Q E R Q +++ GQ +E+ E+ ++ + EK E + +KE++
Sbjct: 680 EEKMQGQEEKMREQEEKMRGQEEKMWGQ-EEKMWGQEEKMWGQEEMREKEERIRDQKEKM 738
Query: 408 LAERDSLREANEELRCAQ 425
++ L E E RC++
Sbjct: 739 ---QERLPEHEE--RCSE 751
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.129 0.355
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,319,077
Number of Sequences: 37866
Number of extensions: 1311163
Number of successful extensions: 17902
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 343
Number of HSP's successfully gapped in prelim test: 1118
Number of HSP's that attempted gapping in prelim test: 6775
Number of HSP's gapped (non-prelim): 5023
length of query: 719
length of database: 18,247,518
effective HSP length: 110
effective length of query: 609
effective length of database: 14,082,258
effective search space: 8576095122
effective search space used: 8576095122
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.