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Search of human proteins with 154146216
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|154146216 pleckstrin homology domain containing, family A
(phosphoinositide binding specific) member 2 [Homo sapiens]
(425 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|154146216 pleckstrin homology domain containing, family A (ph... 873 0.0
gi|50234893 pleckstrin homology domain containing, family A (pho... 328 6e-90
gi|31377720 pleckstrin homology domain containing, family A (pho... 328 6e-90
gi|55741447 pleckstrin homology domain containing, family H (wit... 61 2e-09
gi|217416392 pleckstrin homology domain containing, family H (wi... 59 1e-08
gi|83716021 GRB2-associated binding protein family, member 4 [Ho... 57 4e-08
gi|18105042 GRB2-associated binding protein 2 isoform a [Homo sa... 56 5e-08
gi|158631203 dual adaptor of phosphotyrosine and 3-phosphoinosit... 55 2e-07
gi|156616273 pleckstrin [Homo sapiens] 54 2e-07
gi|37595548 phosphoinositol 3-phosphate-binding protein-3 [Homo ... 53 5e-07
gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo sa... 51 2e-06
gi|145312241 differentially expressed in FDCP 6 homolog [Homo sa... 50 4e-06
gi|110349763 cytohesin 1 isoform 2 [Homo sapiens] 50 4e-06
gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH doma... 49 7e-06
gi|187608516 centaurin, beta 2 [Homo sapiens] 49 7e-06
gi|6912460 GRB2-associated binding protein 2 isoform b [Homo sap... 49 9e-06
gi|7706643 pleckstrin 2 [Homo sapiens] 49 9e-06
gi|4758964 cytohesin 1 isoform 1 [Homo sapiens] 49 1e-05
gi|93102364 SWAP-70 protein [Homo sapiens] 48 1e-05
gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo sa... 47 3e-05
gi|239047795 pleckstrin homology domain containing, family A mem... 47 3e-05
gi|46370073 GRB2-associated binding protein 1 isoform b [Homo sa... 47 3e-05
gi|46370071 GRB2-associated binding protein 1 isoform a [Homo sa... 47 3e-05
gi|154354979 myosin X [Homo sapiens] 47 4e-05
gi|219689123 pleckstrin homology domain containing, family A mem... 46 6e-05
gi|19923493 pleckstrin homology domain containing, family A memb... 46 6e-05
gi|25777598 diacylglycerol kinase, delta 130kDa isoform 2 [Homo ... 46 6e-05
gi|38201692 RAS p21 protein activator 3 [Homo sapiens] 45 1e-04
gi|24432056 hypothetical protein LOC144717 [Homo sapiens] 45 1e-04
gi|4758968 cytohesin 3 [Homo sapiens] 45 1e-04
>gi|154146216 pleckstrin homology domain containing, family A
(phosphoinositide binding specific) member 2 [Homo
sapiens]
Length = 425
Score = 873 bits (2255), Expect = 0.0
Identities = 425/425 (100%), Positives = 425/425 (100%)
Query: 1 MPYVDRQNRICGFLDIEEHENSGKFLRRYFILDTQANCLLWYMDNPQNLAMGAGAVGALQ 60
MPYVDRQNRICGFLDIEEHENSGKFLRRYFILDTQANCLLWYMDNPQNLAMGAGAVGALQ
Sbjct: 1 MPYVDRQNRICGFLDIEEHENSGKFLRRYFILDTQANCLLWYMDNPQNLAMGAGAVGALQ 60
Query: 61 LTYISKVSIATPKQKPKTPFCFVINALSQRYFLQANDQKDMKDWVEALNQASKITVPKGG 120
LTYISKVSIATPKQKPKTPFCFVINALSQRYFLQANDQKDMKDWVEALNQASKITVPKGG
Sbjct: 61 LTYISKVSIATPKQKPKTPFCFVINALSQRYFLQANDQKDMKDWVEALNQASKITVPKGG 120
Query: 121 GLPMTTEVLKSLAAPPALEKKPQVAYKTEIIGGVVVHTPISQNGGDGQEGSEPGSHTILR 180
GLPMTTEVLKSLAAPPALEKKPQVAYKTEIIGGVVVHTPISQNGGDGQEGSEPGSHTILR
Sbjct: 121 GLPMTTEVLKSLAAPPALEKKPQVAYKTEIIGGVVVHTPISQNGGDGQEGSEPGSHTILR 180
Query: 181 RSQSYIPTSGCRASTGPPLIKSGYCVKQGNVRKSWKRRFFALDDFTICYFKCEQDREPLR 240
RSQSYIPTSGCRASTGPPLIKSGYCVKQGNVRKSWKRRFFALDDFTICYFKCEQDREPLR
Sbjct: 181 RSQSYIPTSGCRASTGPPLIKSGYCVKQGNVRKSWKRRFFALDDFTICYFKCEQDREPLR 240
Query: 241 TIFLKDVLKTHECLVKSGDLLMRDNLFEIITSSRTFYVQADSPEDMHSWIKEIGAAVQAL 300
TIFLKDVLKTHECLVKSGDLLMRDNLFEIITSSRTFYVQADSPEDMHSWIKEIGAAVQAL
Sbjct: 241 TIFLKDVLKTHECLVKSGDLLMRDNLFEIITSSRTFYVQADSPEDMHSWIKEIGAAVQAL 300
Query: 301 KCHPRETSFSRSISLTRPGSSSLSSGPNSILCRGRPPLEEKKALCKAPSVASSWQPWTPV 360
KCHPRETSFSRSISLTRPGSSSLSSGPNSILCRGRPPLEEKKALCKAPSVASSWQPWTPV
Sbjct: 301 KCHPRETSFSRSISLTRPGSSSLSSGPNSILCRGRPPLEEKKALCKAPSVASSWQPWTPV 360
Query: 361 PQAGEKLLPPGDTSEDSLFTPRPGEGSAPGVLPSSRIRHRSEPQHPKEKPFMFNLDDENI 420
PQAGEKLLPPGDTSEDSLFTPRPGEGSAPGVLPSSRIRHRSEPQHPKEKPFMFNLDDENI
Sbjct: 361 PQAGEKLLPPGDTSEDSLFTPRPGEGSAPGVLPSSRIRHRSEPQHPKEKPFMFNLDDENI 420
Query: 421 RTSDV 425
RTSDV
Sbjct: 421 RTSDV 425
>gi|50234893 pleckstrin homology domain containing, family A
(phosphoinositide binding specific) member 1 [Homo
sapiens]
Length = 404
Score = 328 bits (841), Expect = 6e-90
Identities = 174/308 (56%), Positives = 220/308 (71%), Gaps = 9/308 (2%)
Query: 1 MPYVDRQNRICGFLDIEEHENSGKFLRRYFILDTQANCLLWYMDNPQNLAMGAGAVGALQ 60
MPYVDRQNRICGFLDIEE+ENSGKFLRRYFILDT+ + +WYMDNPQNL G+ VGA++
Sbjct: 1 MPYVDRQNRICGFLDIEENENSGKFLRRYFILDTREDSFVWYMDNPQNLPSGSSRVGAIK 60
Query: 61 LTYISKVSIATPKQKPKTPFCFVINALSQRYFLQANDQKDMKDWVEALNQASKITVPKGG 120
LTYISKVS AT K +PK FCFV+NA ++YFLQANDQ+D+ +WV LN+A KITVPK
Sbjct: 61 LTYISKVSDAT-KLRPKAEFCFVMNAGMRKYFLQANDQQDLVEWVNVLNKAIKITVPKQS 119
Query: 121 GLPMTTEVLKSLAAPPALEKKPQVAYKTEIIGGVVVHTPISQNGGDGQEGSEPGSHTILR 180
++ +L+ KK QV+Y+T+I+GGV + TP + + E E L+
Sbjct: 120 DSQPNSD---NLSRHGECGKK-QVSYRTDIVGGVPIITPTQKE--EVNECGESIDRNNLK 173
Query: 181 RSQSYIPTSGCRASTGPPLIKSGYCVKQGNVRKSWKRRFFALDDFTICYFKCEQDREPLR 240
RSQS++P + +IK+GYCVKQG V K+WKRR+F LD+ TI YFK E ++EPLR
Sbjct: 174 RSQSHLPYFTPKPPQDSAVIKAGYCVKQGAVMKNWKRRYFQLDENTIGYFKSELEKEPLR 233
Query: 241 TIFLKDVLKTHECLVKSGDLLMRDNLFEIITSSRTFYVQADSPEDMHSWIKEIGAAVQAL 300
I LK+V K EC K D++MRDNLFEI+T+SRTFYVQADSPE+MHSWIK + A+ A
Sbjct: 234 VIPLKEVHKVQEC--KQSDIMMRDNLFEIVTTSRTFYVQADSPEEMHSWIKAVSGAIVAQ 291
Query: 301 KCHPRETS 308
+ R S
Sbjct: 292 RGPGRSAS 299
>gi|31377720 pleckstrin homology domain containing, family A
(phosphoinositide binding specific) member 1 [Homo
sapiens]
Length = 404
Score = 328 bits (841), Expect = 6e-90
Identities = 174/308 (56%), Positives = 220/308 (71%), Gaps = 9/308 (2%)
Query: 1 MPYVDRQNRICGFLDIEEHENSGKFLRRYFILDTQANCLLWYMDNPQNLAMGAGAVGALQ 60
MPYVDRQNRICGFLDIEE+ENSGKFLRRYFILDT+ + +WYMDNPQNL G+ VGA++
Sbjct: 1 MPYVDRQNRICGFLDIEENENSGKFLRRYFILDTREDSFVWYMDNPQNLPSGSSRVGAIK 60
Query: 61 LTYISKVSIATPKQKPKTPFCFVINALSQRYFLQANDQKDMKDWVEALNQASKITVPKGG 120
LTYISKVS AT K +PK FCFV+NA ++YFLQANDQ+D+ +WV LN+A KITVPK
Sbjct: 61 LTYISKVSDAT-KLRPKAEFCFVMNAGMRKYFLQANDQQDLVEWVNVLNKAIKITVPKQS 119
Query: 121 GLPMTTEVLKSLAAPPALEKKPQVAYKTEIIGGVVVHTPISQNGGDGQEGSEPGSHTILR 180
++ +L+ KK QV+Y+T+I+GGV + TP + + E E L+
Sbjct: 120 DSQPNSD---NLSRHGECGKK-QVSYRTDIVGGVPIITPTQKE--EVNECGESIDRNNLK 173
Query: 181 RSQSYIPTSGCRASTGPPLIKSGYCVKQGNVRKSWKRRFFALDDFTICYFKCEQDREPLR 240
RSQS++P + +IK+GYCVKQG V K+WKRR+F LD+ TI YFK E ++EPLR
Sbjct: 174 RSQSHLPYFTPKPPQDSAVIKAGYCVKQGAVMKNWKRRYFQLDENTIGYFKSELEKEPLR 233
Query: 241 TIFLKDVLKTHECLVKSGDLLMRDNLFEIITSSRTFYVQADSPEDMHSWIKEIGAAVQAL 300
I LK+V K EC K D++MRDNLFEI+T+SRTFYVQADSPE+MHSWIK + A+ A
Sbjct: 234 VIPLKEVHKVQEC--KQSDIMMRDNLFEIVTTSRTFYVQADSPEEMHSWIKAVSGAIVAQ 291
Query: 301 KCHPRETS 308
+ R S
Sbjct: 292 RGPGRSAS 299
>gi|55741447 pleckstrin homology domain containing, family H (with
MyTH4 domain) member 1 [Homo sapiens]
Length = 1364
Score = 61.2 bits (147), Expect = 2e-09
Identities = 41/128 (32%), Positives = 64/128 (50%), Gaps = 12/128 (9%)
Query: 179 LRRSQSYIPTSGCRASTGPPLIKSGYCVKQGNVRKSWKRRFFALDDFTICYFKCEQD--R 236
L+R+ SY T G G L KSGY +K G+ K+WKRR+F L I Y+K D R
Sbjct: 561 LQRTSSY-STDGLGLG-GESLEKSGYLLKMGSQVKTWKRRWFVLRQGQIMYYKSPSDVIR 618
Query: 237 EPLRTIFLKDVLKTHECLVKSGDLLMRDNLFEIITSSRTFYVQADSPEDMHSWIKEIGAA 296
+P + L C + G+ F++I+ +T+Y+ ADSP + WI+ + +
Sbjct: 619 KPQGQVDLNS-----RCQIVRGE---GSQTFQLISEKKTYYLTADSPSLLEEWIRVLQSL 670
Query: 297 VQALKCHP 304
++ P
Sbjct: 671 LKVQATGP 678
>gi|217416392 pleckstrin homology domain containing, family H (with
MyTH4 domain) member 2 [Homo sapiens]
Length = 1493
Score = 58.5 bits (140), Expect = 1e-08
Identities = 36/109 (33%), Positives = 52/109 (47%), Gaps = 10/109 (9%)
Query: 198 PLIKSGYCVKQGNVRKSWKRRFFALDDFTICYFKCEQD--REPLRTIFLKDVLKTHECLV 255
PL KSGY +K KSWKRR+F L + Y+K D R+P I L + C +
Sbjct: 703 PLEKSGYLLKMSGKVKSWKRRWFVLKGGELLYYKSPSDVIRKPQGHIEL-----SASCSI 757
Query: 256 KSGDLLMRDNLFEIITSSRTFYVQADSPEDMHSWIKEIGAAVQALKCHP 304
GD ++ T T+Y+ ADSP + WIK + ++ +P
Sbjct: 758 LRGD---NKQTVQLTTEKHTYYLTADSPNILEEWIKVLQNVLRVQAANP 803
>gi|83716021 GRB2-associated binding protein family, member 4 [Homo
sapiens]
Length = 574
Score = 56.6 bits (135), Expect = 4e-08
Identities = 51/190 (26%), Positives = 83/190 (43%), Gaps = 31/190 (16%)
Query: 201 KSGYCVKQGNVRKS----------WKRRFFAL-------DDFTICYFKCEQDREPLRTIF 243
+SG+ + G +RKS W++R+F L D + Y+K + ++PLRTI
Sbjct: 36 RSGHVLYSGWLRKSPPEKKLRLFAWRKRWFILRRGQTSSDPDVLEYYKNDGSKKPLRTIN 95
Query: 244 LK--DVLKTHECLVKSGDLLMRDNLFEIITSSRTFYVQADSPEDMHSWIKEIGAAVQALK 301
L + L L + + + +F+I TS RTFY+ A++ EDM+ W++ I
Sbjct: 96 LNLCEQLDVDVTLNFNKKEIQKGYMFDIKTSERTFYLVAETREDMNEWVQSI-----CQI 150
Query: 302 CHPRETSFSRSISLTRPGSSSLSSGPNSILCRGRPPLEEKKALCKAPSVASSWQPWTPVP 361
C R+ + + S L S P C L +++ P V+ P P+P
Sbjct: 151 CGFRQEESTGFLGNISSASHGLCSSPAEPSC-SHQHLPQEQEPTSEPPVSHCVPPTWPIP 209
Query: 362 QAGEKLLPPG 371
PPG
Sbjct: 210 ------APPG 213
>gi|18105042 GRB2-associated binding protein 2 isoform a [Homo
sapiens]
Length = 676
Score = 56.2 bits (134), Expect = 5e-08
Identities = 48/170 (28%), Positives = 76/170 (44%), Gaps = 13/170 (7%)
Query: 212 RKSWKRRFFAL-------DDFTICYFKCEQDREPLRTIFLKDVLKTHECLVKSGDLLMRD 264
R +WK+R+F L D + Y+K + ++PLR I L + L + L
Sbjct: 24 RYAWKKRWFILRSGRMSGDPDVLEYYKNDHSKKPLRIINLNFCEQVDAGLTFNKKELQDS 83
Query: 265 NLFEIITSSRTFYVQADSPEDMHSWIKEIGAAVQALKCHPRETSFSRSISLTRPGSSSLS 324
+F+I TS RTFY+ A++ EDM+ W++ I + T R++S G
Sbjct: 84 FVFDIKTSERTFYLVAETEEDMNKWVQSI-CQICGFNQAEESTDSLRNVSSAGHGP---R 139
Query: 325 SGPNSILCRGRPPLEEKKALCKAPSVASSWQPWTPVPQAGEKLLPPGDTS 374
S P + + L E+K+ APS +S +T P + P TS
Sbjct: 140 SSPAELSSSSQHLLRERKS--SAPSHSSQPTLFTFEPPVSNHMQPTLSTS 187
>gi|158631203 dual adaptor of phosphotyrosine and
3-phosphoinositides [Homo sapiens]
Length = 280
Score = 54.7 bits (130), Expect = 2e-07
Identities = 36/99 (36%), Positives = 48/99 (48%), Gaps = 8/99 (8%)
Query: 195 TGPPL-IKSGYCVKQGNVRKSWKRRFFALDDFTICYFKCEQDREPLRTIFLKDVLKTHEC 253
T P L K GY KQG + K+WK R+F L + YFK + EP+R +L EC
Sbjct: 160 TAPSLGTKEGYLTKQGGLVKTWKTRWFTLHRNELKYFKDQMSPEPIR------ILDLTEC 213
Query: 254 LVKSGDLLM-RDNLFEIITSSRTFYVQADSPEDMHSWIK 291
D R N F ++ RTFY+ A + + WIK
Sbjct: 214 SAVQFDYSQERVNCFCLVFPFRTFYLCAKTGVEADEWIK 252
>gi|156616273 pleckstrin [Homo sapiens]
Length = 350
Score = 54.3 bits (129), Expect = 2e-07
Identities = 35/101 (34%), Positives = 54/101 (53%), Gaps = 3/101 (2%)
Query: 199 LIKSGYCVKQGNVRKSWKRRFFAL--DDFTICYFKCEQDREPLRTIFLKDVLKTHECLVK 256
+IK G +KQG+ RK+WK R F L D + Y+ +PL I L+ + T
Sbjct: 245 IIKQGCLLKQGHRRKNWKVRKFILREDPAYLHYYDPAGAEDPLGAIHLRGCVVTSVESNS 304
Query: 257 SGDLLMRDNLFEIITSSRT-FYVQADSPEDMHSWIKEIGAA 296
+G +NLFEIIT+ +++QA +P++ WI+ I A
Sbjct: 305 NGRKSEEENLFEIITADEVHYFLQAATPKERTEWIRAIQMA 345
Score = 47.0 bits (110), Expect = 3e-05
Identities = 31/106 (29%), Positives = 54/106 (50%), Gaps = 5/106 (4%)
Query: 197 PPLIKSGYCVKQGNVRKSWKRRFFALDDFTICYFKCEQDREPLRTIFLKDVLKTHECLVK 256
P I+ GY VK+G+V +WK + L + I ++K + D P I LK T C
Sbjct: 3 PKRIREGYLVKKGSVFNTWKPMWVVLLEDGIEFYKKKSDNSPKGMIPLKGSTLTSPC--- 59
Query: 257 SGDLLMRDNLFEIITS-SRTFYVQADSPEDMHSWIKEIGAAVQALK 301
D R +F+I T+ + + QA E+ +W+++I A++ ++
Sbjct: 60 -QDFGKRMFVFKITTTKQQDHFFQAAFLEERDAWVRDIKKAIKCIE 104
Score = 30.4 bits (67), Expect = 3.2
Identities = 23/86 (26%), Positives = 36/86 (41%), Gaps = 2/86 (2%)
Query: 28 RYFILDTQANCLLWYMDNPQNLAMGAGAVGALQLTYISKVSIATPKQKPKTPFCFVINAL 87
R FIL L +Y +P GA+ S S + ++ + +I A
Sbjct: 264 RKFILREDPAYLHYY--DPAGAEDPLGAIHLRGCVVTSVESNSNGRKSEEENLFEIITAD 321
Query: 88 SQRYFLQANDQKDMKDWVEALNQASK 113
YFLQA K+ +W+ A+ AS+
Sbjct: 322 EVHYFLQAATPKERTEWIRAIQMASR 347
>gi|37595548 phosphoinositol 3-phosphate-binding protein-3 [Homo
sapiens]
Length = 1048
Score = 53.1 bits (126), Expect = 5e-07
Identities = 37/130 (28%), Positives = 70/130 (53%), Gaps = 8/130 (6%)
Query: 198 PLIKSGYCVKQGNVR-KSWKRRFFALDDFTICYFKCEQDREPLRTIFLKDVLKTHECLVK 256
P+ K+G+ KQ + K W +R+F L D + Y+K E++ L +I L L V+
Sbjct: 59 PVTKAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESILGSIPL---LSFRVAAVQ 115
Query: 257 SGDLLMRDNLFEIITSS-RTFYVQADSPEDMHSWIKEIGAAVQALKCHPRETSFSRSI-- 313
D + R + F+ + RT++ A+SPE+ +WI+ +G A + ++ P + S +++
Sbjct: 116 PSDNISRKHTFKAEHAGVRTYFFSAESPEEQEAWIQAMGEAAR-VQIPPAQKSVPQAVRH 174
Query: 314 SLTRPGSSSL 323
S +P S ++
Sbjct: 175 SHEKPDSENV 184
Score = 34.3 bits (77), Expect = 0.22
Identities = 18/91 (19%), Positives = 44/91 (48%), Gaps = 7/91 (7%)
Query: 27 RRYFILDTQANCLLWYMDNPQNLAMGAGAVGALQLTYISKVSIATPKQKPKTPFCFVINA 86
+R+F+L + CL +Y D + +G+ + + ++ + + K K V
Sbjct: 79 KRWFVLVDR--CLFYYKDEKEESILGSIPLLSFRVAAVQPSDNISRKHTFKAEHAGV--- 133
Query: 87 LSQRYFLQANDQKDMKDWVEALNQASKITVP 117
+ YF A ++ + W++A+ +A+++ +P
Sbjct: 134 --RTYFFSAESPEEQEAWIQAMGEAARVQIP 162
>gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo
sapiens]
Length = 748
Score = 51.2 bits (121), Expect = 2e-06
Identities = 34/106 (32%), Positives = 50/106 (47%), Gaps = 18/106 (16%)
Query: 200 IKSGYCVKQGNVRKSWKRRFFALDDFTICYFKCEQDREPLRTIFLK-DVLKTHEC----- 253
IK G+ KQG K+W R+F L + YFK E + +PL TIFL + + H C
Sbjct: 21 IKCGWLRKQGGFVKTWHTRWFVLKGDQLYYFKDEDETKPLGTIFLPGNKVSEHPCNEENP 80
Query: 254 ------LVKSGDLLMRDNLFEIITSSRTFYVQADSPEDMHSWIKEI 293
+V GD RD + + ++ + A + DM W+K I
Sbjct: 81 GKFLFEVVPGGD---RDRM---TANHESYLLMASTQNDMEDWVKSI 120
Score = 32.7 bits (73), Expect = 0.64
Identities = 35/131 (26%), Positives = 59/131 (45%), Gaps = 29/131 (22%)
Query: 6 RQNRI-CGFLDIEEHENSGKFLR----RYFILDTQANCLLWYMDNPQNLAMGAGAVGALQ 60
RQN I CG+L G F++ R+F+L + + L ++ D + +G +
Sbjct: 17 RQNAIKCGWL-----RKQGGFVKTWHTRWFVL--KGDQLYYFKDEDETKPLGTIFLPG-- 67
Query: 61 LTYISKVSIATPKQKPKTPFCFVI---------NALSQRYFLQANDQKDMKDWVEALNQA 111
+KVS ++ F F + A + Y L A+ Q DM+DWV+++ +
Sbjct: 68 ----NKVSEHPCNEENPGKFLFEVVPGGDRDRMTANHESYLLMASTQNDMEDWVKSIRRV 123
Query: 112 SKITVPKGGGL 122
I P GGG+
Sbjct: 124 --IWGPFGGGI 132
>gi|145312241 differentially expressed in FDCP 6 homolog [Homo
sapiens]
Length = 631
Score = 50.1 bits (118), Expect = 4e-06
Identities = 28/100 (28%), Positives = 49/100 (49%), Gaps = 4/100 (4%)
Query: 199 LIKSGYCVKQGNVRKSWKRRFFALDDFTICYFKCEQDREPLRTIFLKDVLKTHECLVKSG 258
++K GY K+G++R++W R+F L +CYF E+ +E I L H C+
Sbjct: 217 VLKQGYLWKRGHLRRNWAERWFQLQPSCLCYFGSEECKEKRGII----PLDAHCCVEVLP 272
Query: 259 DLLMRDNLFEIITSSRTFYVQADSPEDMHSWIKEIGAAVQ 298
D + +F + T++RT+ + A W I A++
Sbjct: 273 DRDGKRCMFCVKTANRTYEMSASDTRQRQEWTAAIQMAIR 312
>gi|110349763 cytohesin 1 isoform 2 [Homo sapiens]
Length = 397
Score = 50.1 bits (118), Expect = 4e-06
Identities = 36/137 (26%), Positives = 64/137 (46%), Gaps = 24/137 (17%)
Query: 201 KSGYCVKQGNVRKSWKRRFFALDDFTICYFKCEQDRE-----PLRTIFLKDV--LKTHEC 253
+ G+ +K G K+WKRR+F L D + YF+ D+E PL + +++V K C
Sbjct: 263 REGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDSKKPNC 322
Query: 254 LVKSGDLLMRDNLFEIITSSRT-------------FYVQADSPEDMHSWIKEIGAAVQAL 300
+L + DN ++I + +T + + A +PE+ WIK I AA+
Sbjct: 323 F----ELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEEWIKCIKAAISRD 378
Query: 301 KCHPRETSFSRSISLTR 317
+ + + +S T+
Sbjct: 379 PFYEMLAARKKKVSSTK 395
>gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH domains
3 [Homo sapiens]
Length = 834
Score = 49.3 bits (116), Expect = 7e-06
Identities = 32/133 (24%), Positives = 70/133 (52%), Gaps = 8/133 (6%)
Query: 199 LIKSGYCVKQG-NVRKSWKRRFFALDDFTICYFKCEQDREPLRTIFLKDVLKTHECLVKS 257
++ GY K+ N K+W RR+F++ + + Y K +D T+ + D+ C VK
Sbjct: 269 VVMEGYLFKRASNAFKTWNRRWFSIQNSQLVYQKKLKDA---LTVVVDDL---RLCSVKP 322
Query: 258 GDLLMRDNLFEIITSSRTFYVQADSPEDMHSWIKEIGAAVQALKCHPRETSFSRSISLT- 316
+ + R FE+++ +++ +QADS + +W++ + A++ + ++ +S + T
Sbjct: 323 CEDIERRFCFEVLSPTKSCMLQADSEKLRQAWVQAVQASIASAYRESPDSCYSERLDRTA 382
Query: 317 RPGSSSLSSGPNS 329
P +SS+ S ++
Sbjct: 383 SPSTSSIDSATDT 395
>gi|187608516 centaurin, beta 2 [Homo sapiens]
Length = 778
Score = 49.3 bits (116), Expect = 7e-06
Identities = 34/132 (25%), Positives = 66/132 (50%), Gaps = 8/132 (6%)
Query: 199 LIKSGYCVKQG-NVRKSWKRRFFALDDFTICYFKCEQDREPLRTIFLKDVLKTHECLVKS 257
++ GY K+ N K+W RR+F++ + + Y K +D T+ ++D+ C VK
Sbjct: 267 IVMEGYLFKRASNAFKTWNRRWFSIQNNQLVYQKKFKDNP---TVVVEDL---RLCTVKH 320
Query: 258 GDLLMRDNLFEIITSSRTFYVQADSPEDMHSWIKEIGAAVQALKCHPRETSFSRSISLTR 317
+ + R FE+++ +++ +QADS + +WIK + ++ A + + +
Sbjct: 321 CEDIERRFCFEVVSPTKSCMLQADSEKLRQAWIKAVQTSI-ATAYREKGDESEKLDKKSS 379
Query: 318 PGSSSLSSGPNS 329
P + SL SG S
Sbjct: 380 PSTGSLDSGNES 391
>gi|6912460 GRB2-associated binding protein 2 isoform b [Homo
sapiens]
Length = 638
Score = 48.9 bits (115), Expect = 9e-06
Identities = 41/146 (28%), Positives = 65/146 (44%), Gaps = 6/146 (4%)
Query: 229 YFKCEQDREPLRTIFLKDVLKTHECLVKSGDLLMRDNLFEIITSSRTFYVQADSPEDMHS 288
Y+K + ++PLR I L + L + L +F+I TS RTFY+ A++ EDM+
Sbjct: 10 YYKNDHSKKPLRIINLNFCEQVDAGLTFNKKELQDSFVFDIKTSERTFYLVAETEEDMNK 69
Query: 289 WIKEIGAAVQALKCHPRETSFSRSISLTRPGSSSLSSGPNSILCRGRPPLEEKKALCKAP 348
W++ I + T R++S G S P + + L E+K+ AP
Sbjct: 70 WVQSI-CQICGFNQAEESTDSLRNVSSAGHGP---RSSPAELSSSSQHLLRERKS--SAP 123
Query: 349 SVASSWQPWTPVPQAGEKLLPPGDTS 374
S +S +T P + P TS
Sbjct: 124 SHSSQPTLFTFEPPVSNHMQPTLSTS 149
>gi|7706643 pleckstrin 2 [Homo sapiens]
Length = 353
Score = 48.9 bits (115), Expect = 9e-06
Identities = 33/105 (31%), Positives = 54/105 (51%), Gaps = 8/105 (7%)
Query: 199 LIKSGYCVKQGNVRKSWKRRFFALDDFTICYFKCEQDRE---PLRTIFLKDVLKTHECLV 255
++K G+ VK+G++ +WK R+F L T+ Y+K E R P I L T CL
Sbjct: 5 VLKEGFLVKRGHIVHNWKARWFILRQNTLVYYKLEGGRRVTPPKGRILLDGCTITCPCL- 63
Query: 256 KSGDLLMRDNLFEIITSSRT-FYVQADSPEDMHSWIKEIGAAVQA 299
+ R L ++ T + T ++++A S E+ +W EI A+ A
Sbjct: 64 ---EYENRPLLIKLKTQTSTEYFLEACSREERDAWAFEITGAIHA 105
Score = 45.1 bits (105), Expect = 1e-04
Identities = 33/102 (32%), Positives = 53/102 (51%), Gaps = 7/102 (6%)
Query: 199 LIKSGYCVKQGNVRKSWKRRFFAL---DDFTICYFKCEQDREPLRTIFLKDVLKT--HEC 253
++K GY KQG+ RK+WK R F L F Y +++ P+ L+ L + +
Sbjct: 248 VVKQGYLAKQGHKRKNWKVRRFVLRKDPAFLHYYDPSKEENRPVGGFSLRGSLVSALEDN 307
Query: 254 LVKSG-DLLMRDNLFEIITSSRT-FYVQADSPEDMHSWIKEI 293
V +G ++ NLF++IT T +Y+QA S + WI+ I
Sbjct: 308 GVPTGVKGNVQGNLFKVITKDDTHYYIQASSKAERAEWIEAI 349
>gi|4758964 cytohesin 1 isoform 1 [Homo sapiens]
Length = 398
Score = 48.5 bits (114), Expect = 1e-05
Identities = 37/138 (26%), Positives = 65/138 (47%), Gaps = 25/138 (18%)
Query: 201 KSGYCVKQGNVR-KSWKRRFFALDDFTICYFKCEQDRE-----PLRTIFLKDV--LKTHE 252
+ G+ +K G R K+WKRR+F L D + YF+ D+E PL + +++V K
Sbjct: 263 REGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDSKKPN 322
Query: 253 CLVKSGDLLMRDNLFEIITSSRT-------------FYVQADSPEDMHSWIKEIGAAVQA 299
C +L + DN ++I + +T + + A +PE+ WIK I AA+
Sbjct: 323 CF----ELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEEWIKCIKAAISR 378
Query: 300 LKCHPRETSFSRSISLTR 317
+ + + +S T+
Sbjct: 379 DPFYEMLAARKKKVSSTK 396
>gi|93102364 SWAP-70 protein [Homo sapiens]
Length = 585
Score = 48.1 bits (113), Expect = 1e-05
Identities = 30/104 (28%), Positives = 50/104 (48%), Gaps = 6/104 (5%)
Query: 199 LIKSGYCVKQGNVRKSWKRRFFALDDFTICYFKCEQDREPLRTIFLKDVLKTHECLVKS- 257
++K GY +K+G+ RK+W R+F L I Y+ E ++ D+L C V+S
Sbjct: 211 VLKQGYMMKKGHRRKNWTERWFVLKPNIISYYVSEDLKDK-----KGDILLDENCCVESL 265
Query: 258 GDLLMRDNLFEIITSSRTFYVQADSPEDMHSWIKEIGAAVQALK 301
D + LF + +TF + A + WI+ I + + LK
Sbjct: 266 PDKDGKKCLFLVKCFDKTFEISASDKKKKQEWIQAIHSTIHLLK 309
>gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo
sapiens]
Length = 1054
Score = 47.4 bits (111), Expect = 3e-05
Identities = 50/223 (22%), Positives = 90/223 (40%), Gaps = 21/223 (9%)
Query: 79 PFCFVINALSQRYFLQANDQKDMKDWVEALNQASKITVPKGGG-----LPMTTEVLKSLA 133
P CF I A + + A+ + + + W+ LN A I K GG LP T +
Sbjct: 818 PHCFTIYAAQKTIVVAASTRLEKEKWMLDLNSA--IQAAKSGGDTAPALPGRTVCTR--- 872
Query: 134 APPALEKKPQVAYKTEIIGGVVVHTPISQNGGDGQEGSEPGSHTILRRSQSYIPTSGCRA 193
PP + + ++E V S G GQ + H R+ S S
Sbjct: 873 -PPRSPNEVSLEQESEDDARGVR----SSLEGHGQHRANTTMHVCWYRNTS---VSRADH 924
Query: 194 STGPPLIKSGYCVKQGNVRKSWKRRFFALDDFTICYFKCEQDREPLRTIFLKDVLKTHEC 253
S SGY +++ W++ + +F + ++K QD PL ++ +L
Sbjct: 925 SAAVENQLSGYLLRKFKNSHGWQKLWVVFTNFCLFFYKTHQDDYPLASL---PLLGYSVS 981
Query: 254 LVKSGDLLMRDNLFEIITSSRTFYVQADSPEDMHSWIKEIGAA 296
+ + D + +D +F++ S ++ +A+S W++ I A
Sbjct: 982 IPREADGIHKDYVFKLQFKSHVYFFRAESKYTFERWMEVIQGA 1024
>gi|239047795 pleckstrin homology domain containing, family A member
7 [Homo sapiens]
Length = 1121
Score = 47.0 bits (110), Expect = 3e-05
Identities = 33/130 (25%), Positives = 59/130 (45%), Gaps = 24/130 (18%)
Query: 192 RASTGPPLIKSGYCVKQGNV-RKSWKRRFFALDDFTICYFKCEQDREPLRTIFLKDVLKT 250
R + P++ G+ KQ + + WKRR+F L D+ + Y+K ++ L +I L + +
Sbjct: 158 RRNPNVPVVVRGWLHKQDSSGMRLWKRRWFVLADYCLFYYKDSREEAVLGSIPLPSYVIS 217
Query: 251 HECLVKSGDLLMRDNLFEII--------------------TSSRTFYVQADSPEDMHSWI 290
V D + R F+ + + RT+Y AD+ EDM++W+
Sbjct: 218 P---VAPEDRISRKYSFKAVHTGMRALIYNSSTAGSQAEQSGMRTYYFSADTQEDMNAWV 274
Query: 291 KEIGAAVQAL 300
+ + A Q L
Sbjct: 275 RAMNQAAQVL 284
Score = 35.4 bits (80), Expect = 0.099
Identities = 25/117 (21%), Positives = 54/117 (46%), Gaps = 16/117 (13%)
Query: 12 GFLDIEEHENSGKFLRRYFILDTQANCLLWYMDNPQNLAMGAGAVGALQLTYISKVSIAT 71
G+L ++ + RR+F+L CL +Y D+ + +G+ + + ++ ++ +
Sbjct: 169 GWLHKQDSSGMRLWKRRWFVLADY--CLFYYKDSREEAVLGSIPLPSYVISPVAPEDRIS 226
Query: 72 PKQKPKTPF----CFVINALS----------QRYFLQANDQKDMKDWVEALNQASKI 114
K K + N+ + + Y+ A+ Q+DM WV A+NQA+++
Sbjct: 227 RKYSFKAVHTGMRALIYNSSTAGSQAEQSGMRTYYFSADTQEDMNAWVRAMNQAAQV 283
>gi|46370073 GRB2-associated binding protein 1 isoform b [Homo
sapiens]
Length = 694
Score = 47.0 bits (110), Expect = 3e-05
Identities = 31/108 (28%), Positives = 53/108 (49%), Gaps = 11/108 (10%)
Query: 195 TGPPLIKSGYCVKQGNVRK----SWKRRFFAL-------DDFTICYFKCEQDREPLRTIF 243
+G ++ SG+ K +K +WKRR+F L D + Y+K + ++P+R I
Sbjct: 2 SGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRIID 61
Query: 244 LKDVLKTHECLVKSGDLLMRDNLFEIITSSRTFYVQADSPEDMHSWIK 291
L + L + +F+I T R FY+ ADS E+M+ W++
Sbjct: 62 LNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVR 109
>gi|46370071 GRB2-associated binding protein 1 isoform a [Homo
sapiens]
Length = 724
Score = 47.0 bits (110), Expect = 3e-05
Identities = 31/108 (28%), Positives = 53/108 (49%), Gaps = 11/108 (10%)
Query: 195 TGPPLIKSGYCVKQGNVRK----SWKRRFFAL-------DDFTICYFKCEQDREPLRTIF 243
+G ++ SG+ K +K +WKRR+F L D + Y+K + ++P+R I
Sbjct: 2 SGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRIID 61
Query: 244 LKDVLKTHECLVKSGDLLMRDNLFEIITSSRTFYVQADSPEDMHSWIK 291
L + L + +F+I T R FY+ ADS E+M+ W++
Sbjct: 62 LNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVR 109
>gi|154354979 myosin X [Homo sapiens]
Length = 2058
Score = 46.6 bits (109), Expect = 4e-05
Identities = 28/95 (29%), Positives = 50/95 (52%), Gaps = 12/95 (12%)
Query: 200 IKSGYCVKQGN-----VRKSWKRRFFALDDFTICYFKCEQDREPLRTIFLKDVLKTHECL 254
+K G+ K+G R++WK+R+F L + YF+ + + + T+ +V E +
Sbjct: 1214 LKQGWLHKKGGGSSTLSRRNWKKRWFVLRQSKLMYFENDSEEKLKGTV---EVRTAKEII 1270
Query: 255 VKSGDLLMRDNLFEIITSSRTFYVQADSPEDMHSW 289
D ++N +II + RTF++ A+SPED W
Sbjct: 1271 ----DNTTKENGIDIIMADRTFHLIAESPEDASQW 1301
Score = 37.4 bits (85), Expect = 0.026
Identities = 15/28 (53%), Positives = 20/28 (71%)
Query: 263 RDNLFEIITSSRTFYVQADSPEDMHSWI 290
R N F IIT++R + AD+PE+MH WI
Sbjct: 1349 RPNSFVIITANRVLHCNADTPEEMHHWI 1376
>gi|219689123 pleckstrin homology domain containing, family A member
5 isoform 2 [Homo sapiens]
Length = 1105
Score = 46.2 bits (108), Expect = 6e-05
Identities = 28/106 (26%), Positives = 54/106 (50%), Gaps = 5/106 (4%)
Query: 188 TSGCRASTGPPLIKSGYCVKQGNV-RKSWKRRFFALDDFTICYFKCEQDREPLRTIFLKD 246
++ + + P+++ G+ KQ + K WK+R+F L D + Y++ E++ L +I L
Sbjct: 51 SNSIKRNPNAPVVRRGWLYKQDSTGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPS 110
Query: 247 VLKTHECLVKSGDLLMRDNLFEII-TSSRTFYVQADSPEDMHSWIK 291
L+ S D + R F+ + RT+Y D+ ++M W+K
Sbjct: 111 F---QIALLTSEDHINRKYAFKAAHPNMRTYYFCTDTGKEMELWMK 153
>gi|19923493 pleckstrin homology domain containing, family A member
5 isoform 1 [Homo sapiens]
Length = 1116
Score = 46.2 bits (108), Expect = 6e-05
Identities = 28/106 (26%), Positives = 54/106 (50%), Gaps = 5/106 (4%)
Query: 188 TSGCRASTGPPLIKSGYCVKQGNV-RKSWKRRFFALDDFTICYFKCEQDREPLRTIFLKD 246
++ + + P+++ G+ KQ + K WK+R+F L D + Y++ E++ L +I L
Sbjct: 159 SNSIKRNPNAPVVRRGWLYKQDSTGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPS 218
Query: 247 VLKTHECLVKSGDLLMRDNLFEII-TSSRTFYVQADSPEDMHSWIK 291
L+ S D + R F+ + RT+Y D+ ++M W+K
Sbjct: 219 F---QIALLTSEDHINRKYAFKAAHPNMRTYYFCTDTGKEMELWMK 261
>gi|25777598 diacylglycerol kinase, delta 130kDa isoform 2 [Homo
sapiens]
Length = 1214
Score = 46.2 bits (108), Expect = 6e-05
Identities = 42/133 (31%), Positives = 61/133 (45%), Gaps = 14/133 (10%)
Query: 159 PISQNGGDGQEGSEPGSHTILRRSQSYIPTSG-CRASTGPPLIKSGYCVKQGNVRKSWKR 217
P + D + +EPGS L R S TSG R T +IK G KQ N + KR
Sbjct: 19 PPPEESSDSEPEAEPGSPQKLIRKVS---TSGQIRQKT---IIKEGMLTKQNNSFQRSKR 72
Query: 218 RFFALDDFTICYFKCEQDREPLRTIFLKDVLKTHECLVKSGDLLMRDNLFEIITSSRTFY 277
R+F L T+ Y K ++I +V T + +S + +N F +IT R
Sbjct: 73 RYFKLRGRTLYYAK------TAKSIIFDEVDLTDASVAESSTKNV-NNSFTVITPCRKLI 125
Query: 278 VQADSPEDMHSWI 290
+ AD+ ++M WI
Sbjct: 126 LCADNRKEMEDWI 138
>gi|38201692 RAS p21 protein activator 3 [Homo sapiens]
Length = 834
Score = 45.4 bits (106), Expect = 1e-04
Identities = 27/99 (27%), Positives = 54/99 (54%), Gaps = 9/99 (9%)
Query: 197 PPLIKSGYCVKQGNVRK-----SWKRRFFALDDFTICYFKCEQDREPLRTIFLKDVLKTH 251
P ++K G+ +K+ RK ++K+R+F L + Y K + D +PL +I ++++L
Sbjct: 575 PIVLKEGFMIKRAQGRKRFGMKNFKKRWFRLTNHEFTYHKSKGD-QPLYSIPIENILAVE 633
Query: 252 ECLVKSGDLLMRDNLFEIITSSRTFYVQADSPEDMHSWI 290
+ +S + N+F++I R Y+QA++ + WI
Sbjct: 634 KLEEESFKM---KNMFQVIQPERALYIQANNCVEAKDWI 669
>gi|24432056 hypothetical protein LOC144717 [Homo sapiens]
Length = 249
Score = 45.4 bits (106), Expect = 1e-04
Identities = 49/198 (24%), Positives = 82/198 (41%), Gaps = 15/198 (7%)
Query: 193 ASTGPPLIKSGYCVKQGNVRKSWKRRFFALDDFTICYFKCEQDREPLRTIFLKDVLKTHE 252
A+ P+ +G+ K+G ++ RR+F L + YF+ REP+ I L+ T E
Sbjct: 12 ATCDAPVDNAGFLYKKGGRHAAYHRRWFVLRGNMLFYFEDAASREPVGVIILEGC--TVE 69
Query: 253 CLVKSGDLLMRDNLFEIITSSRTFYVQADSPEDMHSWIKEIG-AAVQALKCHPRETSFSR 311
+ + + T +RT+ + A+S + M W+K + A+ L+ RE +
Sbjct: 70 LVEAAEEFAFAVRFAG--TRARTYVLAAESQDAMEGWVKALSRASFDYLRLVVRE--LEQ 125
Query: 312 SISLTRPGSSSLSSGPNSILCRGRPPLEEKKALCKAPSVASSWQPWTPVP-QAGEKLLPP 370
++ R G P P L AL PS+ S+ P +P LPP
Sbjct: 126 QLAAVRGGGGMALPQPQPQSLPLPPSL--PSALAPVPSLPSAPAPVPALPLPRRPSALPP 183
Query: 371 GDT-----SEDSLFTPRP 383
+ S ++ F P P
Sbjct: 184 KENGCAVWSTEATFRPGP 201
>gi|4758968 cytohesin 3 [Homo sapiens]
Length = 399
Score = 45.1 bits (105), Expect = 1e-04
Identities = 28/119 (23%), Positives = 50/119 (42%), Gaps = 28/119 (23%)
Query: 201 KSGYCVKQGNVRKSWKRRFFALDDFTICYFKCEQDREPLRTIFLKDVLKTHECLVKSGDL 260
+ G+ +K G K+WKRR+F L D + YF+ D+EP + ++ ++ +
Sbjct: 267 REGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEP------RGIIPLENLSIREVED 320
Query: 261 LMRDNLFEIITSSR----------------------TFYVQADSPEDMHSWIKEIGAAV 297
+ N FE+ S + + A SPE+ W+K I A++
Sbjct: 321 PRKPNCFELYNPSHKGQVIKACKTEADGRVVEGNHVVYRISAPSPEEKEEWMKSIKASI 379
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.134 0.410
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,050,605
Number of Sequences: 37866
Number of extensions: 984609
Number of successful extensions: 3617
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 69
Number of HSP's successfully gapped in prelim test: 129
Number of HSP's that attempted gapping in prelim test: 3373
Number of HSP's gapped (non-prelim): 321
length of query: 425
length of database: 18,247,518
effective HSP length: 105
effective length of query: 320
effective length of database: 14,271,588
effective search space: 4566908160
effective search space used: 4566908160
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.