BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|154146216 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 [Homo sapiens] (425 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|154146216 pleckstrin homology domain containing, family A (ph... 873 0.0 gi|50234893 pleckstrin homology domain containing, family A (pho... 328 6e-90 gi|31377720 pleckstrin homology domain containing, family A (pho... 328 6e-90 gi|55741447 pleckstrin homology domain containing, family H (wit... 61 2e-09 gi|217416392 pleckstrin homology domain containing, family H (wi... 59 1e-08 gi|83716021 GRB2-associated binding protein family, member 4 [Ho... 57 4e-08 gi|18105042 GRB2-associated binding protein 2 isoform a [Homo sa... 56 5e-08 gi|158631203 dual adaptor of phosphotyrosine and 3-phosphoinosit... 55 2e-07 gi|156616273 pleckstrin [Homo sapiens] 54 2e-07 gi|37595548 phosphoinositol 3-phosphate-binding protein-3 [Homo ... 53 5e-07 gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo sa... 51 2e-06 gi|145312241 differentially expressed in FDCP 6 homolog [Homo sa... 50 4e-06 gi|110349763 cytohesin 1 isoform 2 [Homo sapiens] 50 4e-06 gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH doma... 49 7e-06 gi|187608516 centaurin, beta 2 [Homo sapiens] 49 7e-06 gi|6912460 GRB2-associated binding protein 2 isoform b [Homo sap... 49 9e-06 gi|7706643 pleckstrin 2 [Homo sapiens] 49 9e-06 gi|4758964 cytohesin 1 isoform 1 [Homo sapiens] 49 1e-05 gi|93102364 SWAP-70 protein [Homo sapiens] 48 1e-05 gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo sa... 47 3e-05 gi|239047795 pleckstrin homology domain containing, family A mem... 47 3e-05 gi|46370073 GRB2-associated binding protein 1 isoform b [Homo sa... 47 3e-05 gi|46370071 GRB2-associated binding protein 1 isoform a [Homo sa... 47 3e-05 gi|154354979 myosin X [Homo sapiens] 47 4e-05 gi|219689123 pleckstrin homology domain containing, family A mem... 46 6e-05 gi|19923493 pleckstrin homology domain containing, family A memb... 46 6e-05 gi|25777598 diacylglycerol kinase, delta 130kDa isoform 2 [Homo ... 46 6e-05 gi|38201692 RAS p21 protein activator 3 [Homo sapiens] 45 1e-04 gi|24432056 hypothetical protein LOC144717 [Homo sapiens] 45 1e-04 gi|4758968 cytohesin 3 [Homo sapiens] 45 1e-04 >gi|154146216 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 [Homo sapiens] Length = 425 Score = 873 bits (2255), Expect = 0.0 Identities = 425/425 (100%), Positives = 425/425 (100%) Query: 1 MPYVDRQNRICGFLDIEEHENSGKFLRRYFILDTQANCLLWYMDNPQNLAMGAGAVGALQ 60 MPYVDRQNRICGFLDIEEHENSGKFLRRYFILDTQANCLLWYMDNPQNLAMGAGAVGALQ Sbjct: 1 MPYVDRQNRICGFLDIEEHENSGKFLRRYFILDTQANCLLWYMDNPQNLAMGAGAVGALQ 60 Query: 61 LTYISKVSIATPKQKPKTPFCFVINALSQRYFLQANDQKDMKDWVEALNQASKITVPKGG 120 LTYISKVSIATPKQKPKTPFCFVINALSQRYFLQANDQKDMKDWVEALNQASKITVPKGG Sbjct: 61 LTYISKVSIATPKQKPKTPFCFVINALSQRYFLQANDQKDMKDWVEALNQASKITVPKGG 120 Query: 121 GLPMTTEVLKSLAAPPALEKKPQVAYKTEIIGGVVVHTPISQNGGDGQEGSEPGSHTILR 180 GLPMTTEVLKSLAAPPALEKKPQVAYKTEIIGGVVVHTPISQNGGDGQEGSEPGSHTILR Sbjct: 121 GLPMTTEVLKSLAAPPALEKKPQVAYKTEIIGGVVVHTPISQNGGDGQEGSEPGSHTILR 180 Query: 181 RSQSYIPTSGCRASTGPPLIKSGYCVKQGNVRKSWKRRFFALDDFTICYFKCEQDREPLR 240 RSQSYIPTSGCRASTGPPLIKSGYCVKQGNVRKSWKRRFFALDDFTICYFKCEQDREPLR Sbjct: 181 RSQSYIPTSGCRASTGPPLIKSGYCVKQGNVRKSWKRRFFALDDFTICYFKCEQDREPLR 240 Query: 241 TIFLKDVLKTHECLVKSGDLLMRDNLFEIITSSRTFYVQADSPEDMHSWIKEIGAAVQAL 300 TIFLKDVLKTHECLVKSGDLLMRDNLFEIITSSRTFYVQADSPEDMHSWIKEIGAAVQAL Sbjct: 241 TIFLKDVLKTHECLVKSGDLLMRDNLFEIITSSRTFYVQADSPEDMHSWIKEIGAAVQAL 300 Query: 301 KCHPRETSFSRSISLTRPGSSSLSSGPNSILCRGRPPLEEKKALCKAPSVASSWQPWTPV 360 KCHPRETSFSRSISLTRPGSSSLSSGPNSILCRGRPPLEEKKALCKAPSVASSWQPWTPV Sbjct: 301 KCHPRETSFSRSISLTRPGSSSLSSGPNSILCRGRPPLEEKKALCKAPSVASSWQPWTPV 360 Query: 361 PQAGEKLLPPGDTSEDSLFTPRPGEGSAPGVLPSSRIRHRSEPQHPKEKPFMFNLDDENI 420 PQAGEKLLPPGDTSEDSLFTPRPGEGSAPGVLPSSRIRHRSEPQHPKEKPFMFNLDDENI Sbjct: 361 PQAGEKLLPPGDTSEDSLFTPRPGEGSAPGVLPSSRIRHRSEPQHPKEKPFMFNLDDENI 420 Query: 421 RTSDV 425 RTSDV Sbjct: 421 RTSDV 425 >gi|50234893 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 [Homo sapiens] Length = 404 Score = 328 bits (841), Expect = 6e-90 Identities = 174/308 (56%), Positives = 220/308 (71%), Gaps = 9/308 (2%) Query: 1 MPYVDRQNRICGFLDIEEHENSGKFLRRYFILDTQANCLLWYMDNPQNLAMGAGAVGALQ 60 MPYVDRQNRICGFLDIEE+ENSGKFLRRYFILDT+ + +WYMDNPQNL G+ VGA++ Sbjct: 1 MPYVDRQNRICGFLDIEENENSGKFLRRYFILDTREDSFVWYMDNPQNLPSGSSRVGAIK 60 Query: 61 LTYISKVSIATPKQKPKTPFCFVINALSQRYFLQANDQKDMKDWVEALNQASKITVPKGG 120 LTYISKVS AT K +PK FCFV+NA ++YFLQANDQ+D+ +WV LN+A KITVPK Sbjct: 61 LTYISKVSDAT-KLRPKAEFCFVMNAGMRKYFLQANDQQDLVEWVNVLNKAIKITVPKQS 119 Query: 121 GLPMTTEVLKSLAAPPALEKKPQVAYKTEIIGGVVVHTPISQNGGDGQEGSEPGSHTILR 180 ++ +L+ KK QV+Y+T+I+GGV + TP + + E E L+ Sbjct: 120 DSQPNSD---NLSRHGECGKK-QVSYRTDIVGGVPIITPTQKE--EVNECGESIDRNNLK 173 Query: 181 RSQSYIPTSGCRASTGPPLIKSGYCVKQGNVRKSWKRRFFALDDFTICYFKCEQDREPLR 240 RSQS++P + +IK+GYCVKQG V K+WKRR+F LD+ TI YFK E ++EPLR Sbjct: 174 RSQSHLPYFTPKPPQDSAVIKAGYCVKQGAVMKNWKRRYFQLDENTIGYFKSELEKEPLR 233 Query: 241 TIFLKDVLKTHECLVKSGDLLMRDNLFEIITSSRTFYVQADSPEDMHSWIKEIGAAVQAL 300 I LK+V K EC K D++MRDNLFEI+T+SRTFYVQADSPE+MHSWIK + A+ A Sbjct: 234 VIPLKEVHKVQEC--KQSDIMMRDNLFEIVTTSRTFYVQADSPEEMHSWIKAVSGAIVAQ 291 Query: 301 KCHPRETS 308 + R S Sbjct: 292 RGPGRSAS 299 >gi|31377720 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 [Homo sapiens] Length = 404 Score = 328 bits (841), Expect = 6e-90 Identities = 174/308 (56%), Positives = 220/308 (71%), Gaps = 9/308 (2%) Query: 1 MPYVDRQNRICGFLDIEEHENSGKFLRRYFILDTQANCLLWYMDNPQNLAMGAGAVGALQ 60 MPYVDRQNRICGFLDIEE+ENSGKFLRRYFILDT+ + +WYMDNPQNL G+ VGA++ Sbjct: 1 MPYVDRQNRICGFLDIEENENSGKFLRRYFILDTREDSFVWYMDNPQNLPSGSSRVGAIK 60 Query: 61 LTYISKVSIATPKQKPKTPFCFVINALSQRYFLQANDQKDMKDWVEALNQASKITVPKGG 120 LTYISKVS AT K +PK FCFV+NA ++YFLQANDQ+D+ +WV LN+A KITVPK Sbjct: 61 LTYISKVSDAT-KLRPKAEFCFVMNAGMRKYFLQANDQQDLVEWVNVLNKAIKITVPKQS 119 Query: 121 GLPMTTEVLKSLAAPPALEKKPQVAYKTEIIGGVVVHTPISQNGGDGQEGSEPGSHTILR 180 ++ +L+ KK QV+Y+T+I+GGV + TP + + E E L+ Sbjct: 120 DSQPNSD---NLSRHGECGKK-QVSYRTDIVGGVPIITPTQKE--EVNECGESIDRNNLK 173 Query: 181 RSQSYIPTSGCRASTGPPLIKSGYCVKQGNVRKSWKRRFFALDDFTICYFKCEQDREPLR 240 RSQS++P + +IK+GYCVKQG V K+WKRR+F LD+ TI YFK E ++EPLR Sbjct: 174 RSQSHLPYFTPKPPQDSAVIKAGYCVKQGAVMKNWKRRYFQLDENTIGYFKSELEKEPLR 233 Query: 241 TIFLKDVLKTHECLVKSGDLLMRDNLFEIITSSRTFYVQADSPEDMHSWIKEIGAAVQAL 300 I LK+V K EC K D++MRDNLFEI+T+SRTFYVQADSPE+MHSWIK + A+ A Sbjct: 234 VIPLKEVHKVQEC--KQSDIMMRDNLFEIVTTSRTFYVQADSPEEMHSWIKAVSGAIVAQ 291 Query: 301 KCHPRETS 308 + R S Sbjct: 292 RGPGRSAS 299 >gi|55741447 pleckstrin homology domain containing, family H (with MyTH4 domain) member 1 [Homo sapiens] Length = 1364 Score = 61.2 bits (147), Expect = 2e-09 Identities = 41/128 (32%), Positives = 64/128 (50%), Gaps = 12/128 (9%) Query: 179 LRRSQSYIPTSGCRASTGPPLIKSGYCVKQGNVRKSWKRRFFALDDFTICYFKCEQD--R 236 L+R+ SY T G G L KSGY +K G+ K+WKRR+F L I Y+K D R Sbjct: 561 LQRTSSY-STDGLGLG-GESLEKSGYLLKMGSQVKTWKRRWFVLRQGQIMYYKSPSDVIR 618 Query: 237 EPLRTIFLKDVLKTHECLVKSGDLLMRDNLFEIITSSRTFYVQADSPEDMHSWIKEIGAA 296 +P + L C + G+ F++I+ +T+Y+ ADSP + WI+ + + Sbjct: 619 KPQGQVDLNS-----RCQIVRGE---GSQTFQLISEKKTYYLTADSPSLLEEWIRVLQSL 670 Query: 297 VQALKCHP 304 ++ P Sbjct: 671 LKVQATGP 678 >gi|217416392 pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 [Homo sapiens] Length = 1493 Score = 58.5 bits (140), Expect = 1e-08 Identities = 36/109 (33%), Positives = 52/109 (47%), Gaps = 10/109 (9%) Query: 198 PLIKSGYCVKQGNVRKSWKRRFFALDDFTICYFKCEQD--REPLRTIFLKDVLKTHECLV 255 PL KSGY +K KSWKRR+F L + Y+K D R+P I L + C + Sbjct: 703 PLEKSGYLLKMSGKVKSWKRRWFVLKGGELLYYKSPSDVIRKPQGHIEL-----SASCSI 757 Query: 256 KSGDLLMRDNLFEIITSSRTFYVQADSPEDMHSWIKEIGAAVQALKCHP 304 GD ++ T T+Y+ ADSP + WIK + ++ +P Sbjct: 758 LRGD---NKQTVQLTTEKHTYYLTADSPNILEEWIKVLQNVLRVQAANP 803 >gi|83716021 GRB2-associated binding protein family, member 4 [Homo sapiens] Length = 574 Score = 56.6 bits (135), Expect = 4e-08 Identities = 51/190 (26%), Positives = 83/190 (43%), Gaps = 31/190 (16%) Query: 201 KSGYCVKQGNVRKS----------WKRRFFAL-------DDFTICYFKCEQDREPLRTIF 243 +SG+ + G +RKS W++R+F L D + Y+K + ++PLRTI Sbjct: 36 RSGHVLYSGWLRKSPPEKKLRLFAWRKRWFILRRGQTSSDPDVLEYYKNDGSKKPLRTIN 95 Query: 244 LK--DVLKTHECLVKSGDLLMRDNLFEIITSSRTFYVQADSPEDMHSWIKEIGAAVQALK 301 L + L L + + + +F+I TS RTFY+ A++ EDM+ W++ I Sbjct: 96 LNLCEQLDVDVTLNFNKKEIQKGYMFDIKTSERTFYLVAETREDMNEWVQSI-----CQI 150 Query: 302 CHPRETSFSRSISLTRPGSSSLSSGPNSILCRGRPPLEEKKALCKAPSVASSWQPWTPVP 361 C R+ + + S L S P C L +++ P V+ P P+P Sbjct: 151 CGFRQEESTGFLGNISSASHGLCSSPAEPSC-SHQHLPQEQEPTSEPPVSHCVPPTWPIP 209 Query: 362 QAGEKLLPPG 371 PPG Sbjct: 210 ------APPG 213 >gi|18105042 GRB2-associated binding protein 2 isoform a [Homo sapiens] Length = 676 Score = 56.2 bits (134), Expect = 5e-08 Identities = 48/170 (28%), Positives = 76/170 (44%), Gaps = 13/170 (7%) Query: 212 RKSWKRRFFAL-------DDFTICYFKCEQDREPLRTIFLKDVLKTHECLVKSGDLLMRD 264 R +WK+R+F L D + Y+K + ++PLR I L + L + L Sbjct: 24 RYAWKKRWFILRSGRMSGDPDVLEYYKNDHSKKPLRIINLNFCEQVDAGLTFNKKELQDS 83 Query: 265 NLFEIITSSRTFYVQADSPEDMHSWIKEIGAAVQALKCHPRETSFSRSISLTRPGSSSLS 324 +F+I TS RTFY+ A++ EDM+ W++ I + T R++S G Sbjct: 84 FVFDIKTSERTFYLVAETEEDMNKWVQSI-CQICGFNQAEESTDSLRNVSSAGHGP---R 139 Query: 325 SGPNSILCRGRPPLEEKKALCKAPSVASSWQPWTPVPQAGEKLLPPGDTS 374 S P + + L E+K+ APS +S +T P + P TS Sbjct: 140 SSPAELSSSSQHLLRERKS--SAPSHSSQPTLFTFEPPVSNHMQPTLSTS 187 >gi|158631203 dual adaptor of phosphotyrosine and 3-phosphoinositides [Homo sapiens] Length = 280 Score = 54.7 bits (130), Expect = 2e-07 Identities = 36/99 (36%), Positives = 48/99 (48%), Gaps = 8/99 (8%) Query: 195 TGPPL-IKSGYCVKQGNVRKSWKRRFFALDDFTICYFKCEQDREPLRTIFLKDVLKTHEC 253 T P L K GY KQG + K+WK R+F L + YFK + EP+R +L EC Sbjct: 160 TAPSLGTKEGYLTKQGGLVKTWKTRWFTLHRNELKYFKDQMSPEPIR------ILDLTEC 213 Query: 254 LVKSGDLLM-RDNLFEIITSSRTFYVQADSPEDMHSWIK 291 D R N F ++ RTFY+ A + + WIK Sbjct: 214 SAVQFDYSQERVNCFCLVFPFRTFYLCAKTGVEADEWIK 252 >gi|156616273 pleckstrin [Homo sapiens] Length = 350 Score = 54.3 bits (129), Expect = 2e-07 Identities = 35/101 (34%), Positives = 54/101 (53%), Gaps = 3/101 (2%) Query: 199 LIKSGYCVKQGNVRKSWKRRFFAL--DDFTICYFKCEQDREPLRTIFLKDVLKTHECLVK 256 +IK G +KQG+ RK+WK R F L D + Y+ +PL I L+ + T Sbjct: 245 IIKQGCLLKQGHRRKNWKVRKFILREDPAYLHYYDPAGAEDPLGAIHLRGCVVTSVESNS 304 Query: 257 SGDLLMRDNLFEIITSSRT-FYVQADSPEDMHSWIKEIGAA 296 +G +NLFEIIT+ +++QA +P++ WI+ I A Sbjct: 305 NGRKSEEENLFEIITADEVHYFLQAATPKERTEWIRAIQMA 345 Score = 47.0 bits (110), Expect = 3e-05 Identities = 31/106 (29%), Positives = 54/106 (50%), Gaps = 5/106 (4%) Query: 197 PPLIKSGYCVKQGNVRKSWKRRFFALDDFTICYFKCEQDREPLRTIFLKDVLKTHECLVK 256 P I+ GY VK+G+V +WK + L + I ++K + D P I LK T C Sbjct: 3 PKRIREGYLVKKGSVFNTWKPMWVVLLEDGIEFYKKKSDNSPKGMIPLKGSTLTSPC--- 59 Query: 257 SGDLLMRDNLFEIITS-SRTFYVQADSPEDMHSWIKEIGAAVQALK 301 D R +F+I T+ + + QA E+ +W+++I A++ ++ Sbjct: 60 -QDFGKRMFVFKITTTKQQDHFFQAAFLEERDAWVRDIKKAIKCIE 104 Score = 30.4 bits (67), Expect = 3.2 Identities = 23/86 (26%), Positives = 36/86 (41%), Gaps = 2/86 (2%) Query: 28 RYFILDTQANCLLWYMDNPQNLAMGAGAVGALQLTYISKVSIATPKQKPKTPFCFVINAL 87 R FIL L +Y +P GA+ S S + ++ + +I A Sbjct: 264 RKFILREDPAYLHYY--DPAGAEDPLGAIHLRGCVVTSVESNSNGRKSEEENLFEIITAD 321 Query: 88 SQRYFLQANDQKDMKDWVEALNQASK 113 YFLQA K+ +W+ A+ AS+ Sbjct: 322 EVHYFLQAATPKERTEWIRAIQMASR 347 >gi|37595548 phosphoinositol 3-phosphate-binding protein-3 [Homo sapiens] Length = 1048 Score = 53.1 bits (126), Expect = 5e-07 Identities = 37/130 (28%), Positives = 70/130 (53%), Gaps = 8/130 (6%) Query: 198 PLIKSGYCVKQGNVR-KSWKRRFFALDDFTICYFKCEQDREPLRTIFLKDVLKTHECLVK 256 P+ K+G+ KQ + K W +R+F L D + Y+K E++ L +I L L V+ Sbjct: 59 PVTKAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESILGSIPL---LSFRVAAVQ 115 Query: 257 SGDLLMRDNLFEIITSS-RTFYVQADSPEDMHSWIKEIGAAVQALKCHPRETSFSRSI-- 313 D + R + F+ + RT++ A+SPE+ +WI+ +G A + ++ P + S +++ Sbjct: 116 PSDNISRKHTFKAEHAGVRTYFFSAESPEEQEAWIQAMGEAAR-VQIPPAQKSVPQAVRH 174 Query: 314 SLTRPGSSSL 323 S +P S ++ Sbjct: 175 SHEKPDSENV 184 Score = 34.3 bits (77), Expect = 0.22 Identities = 18/91 (19%), Positives = 44/91 (48%), Gaps = 7/91 (7%) Query: 27 RRYFILDTQANCLLWYMDNPQNLAMGAGAVGALQLTYISKVSIATPKQKPKTPFCFVINA 86 +R+F+L + CL +Y D + +G+ + + ++ + + K K V Sbjct: 79 KRWFVLVDR--CLFYYKDEKEESILGSIPLLSFRVAAVQPSDNISRKHTFKAEHAGV--- 133 Query: 87 LSQRYFLQANDQKDMKDWVEALNQASKITVP 117 + YF A ++ + W++A+ +A+++ +P Sbjct: 134 --RTYFFSAESPEEQEAWIQAMGEAARVQIP 162 >gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo sapiens] Length = 748 Score = 51.2 bits (121), Expect = 2e-06 Identities = 34/106 (32%), Positives = 50/106 (47%), Gaps = 18/106 (16%) Query: 200 IKSGYCVKQGNVRKSWKRRFFALDDFTICYFKCEQDREPLRTIFLK-DVLKTHEC----- 253 IK G+ KQG K+W R+F L + YFK E + +PL TIFL + + H C Sbjct: 21 IKCGWLRKQGGFVKTWHTRWFVLKGDQLYYFKDEDETKPLGTIFLPGNKVSEHPCNEENP 80 Query: 254 ------LVKSGDLLMRDNLFEIITSSRTFYVQADSPEDMHSWIKEI 293 +V GD RD + + ++ + A + DM W+K I Sbjct: 81 GKFLFEVVPGGD---RDRM---TANHESYLLMASTQNDMEDWVKSI 120 Score = 32.7 bits (73), Expect = 0.64 Identities = 35/131 (26%), Positives = 59/131 (45%), Gaps = 29/131 (22%) Query: 6 RQNRI-CGFLDIEEHENSGKFLR----RYFILDTQANCLLWYMDNPQNLAMGAGAVGALQ 60 RQN I CG+L G F++ R+F+L + + L ++ D + +G + Sbjct: 17 RQNAIKCGWL-----RKQGGFVKTWHTRWFVL--KGDQLYYFKDEDETKPLGTIFLPG-- 67 Query: 61 LTYISKVSIATPKQKPKTPFCFVI---------NALSQRYFLQANDQKDMKDWVEALNQA 111 +KVS ++ F F + A + Y L A+ Q DM+DWV+++ + Sbjct: 68 ----NKVSEHPCNEENPGKFLFEVVPGGDRDRMTANHESYLLMASTQNDMEDWVKSIRRV 123 Query: 112 SKITVPKGGGL 122 I P GGG+ Sbjct: 124 --IWGPFGGGI 132 >gi|145312241 differentially expressed in FDCP 6 homolog [Homo sapiens] Length = 631 Score = 50.1 bits (118), Expect = 4e-06 Identities = 28/100 (28%), Positives = 49/100 (49%), Gaps = 4/100 (4%) Query: 199 LIKSGYCVKQGNVRKSWKRRFFALDDFTICYFKCEQDREPLRTIFLKDVLKTHECLVKSG 258 ++K GY K+G++R++W R+F L +CYF E+ +E I L H C+ Sbjct: 217 VLKQGYLWKRGHLRRNWAERWFQLQPSCLCYFGSEECKEKRGII----PLDAHCCVEVLP 272 Query: 259 DLLMRDNLFEIITSSRTFYVQADSPEDMHSWIKEIGAAVQ 298 D + +F + T++RT+ + A W I A++ Sbjct: 273 DRDGKRCMFCVKTANRTYEMSASDTRQRQEWTAAIQMAIR 312 >gi|110349763 cytohesin 1 isoform 2 [Homo sapiens] Length = 397 Score = 50.1 bits (118), Expect = 4e-06 Identities = 36/137 (26%), Positives = 64/137 (46%), Gaps = 24/137 (17%) Query: 201 KSGYCVKQGNVRKSWKRRFFALDDFTICYFKCEQDRE-----PLRTIFLKDV--LKTHEC 253 + G+ +K G K+WKRR+F L D + YF+ D+E PL + +++V K C Sbjct: 263 REGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDSKKPNC 322 Query: 254 LVKSGDLLMRDNLFEIITSSRT-------------FYVQADSPEDMHSWIKEIGAAVQAL 300 +L + DN ++I + +T + + A +PE+ WIK I AA+ Sbjct: 323 F----ELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEEWIKCIKAAISRD 378 Query: 301 KCHPRETSFSRSISLTR 317 + + + +S T+ Sbjct: 379 PFYEMLAARKKKVSSTK 395 >gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 [Homo sapiens] Length = 834 Score = 49.3 bits (116), Expect = 7e-06 Identities = 32/133 (24%), Positives = 70/133 (52%), Gaps = 8/133 (6%) Query: 199 LIKSGYCVKQG-NVRKSWKRRFFALDDFTICYFKCEQDREPLRTIFLKDVLKTHECLVKS 257 ++ GY K+ N K+W RR+F++ + + Y K +D T+ + D+ C VK Sbjct: 269 VVMEGYLFKRASNAFKTWNRRWFSIQNSQLVYQKKLKDA---LTVVVDDL---RLCSVKP 322 Query: 258 GDLLMRDNLFEIITSSRTFYVQADSPEDMHSWIKEIGAAVQALKCHPRETSFSRSISLT- 316 + + R FE+++ +++ +QADS + +W++ + A++ + ++ +S + T Sbjct: 323 CEDIERRFCFEVLSPTKSCMLQADSEKLRQAWVQAVQASIASAYRESPDSCYSERLDRTA 382 Query: 317 RPGSSSLSSGPNS 329 P +SS+ S ++ Sbjct: 383 SPSTSSIDSATDT 395 >gi|187608516 centaurin, beta 2 [Homo sapiens] Length = 778 Score = 49.3 bits (116), Expect = 7e-06 Identities = 34/132 (25%), Positives = 66/132 (50%), Gaps = 8/132 (6%) Query: 199 LIKSGYCVKQG-NVRKSWKRRFFALDDFTICYFKCEQDREPLRTIFLKDVLKTHECLVKS 257 ++ GY K+ N K+W RR+F++ + + Y K +D T+ ++D+ C VK Sbjct: 267 IVMEGYLFKRASNAFKTWNRRWFSIQNNQLVYQKKFKDNP---TVVVEDL---RLCTVKH 320 Query: 258 GDLLMRDNLFEIITSSRTFYVQADSPEDMHSWIKEIGAAVQALKCHPRETSFSRSISLTR 317 + + R FE+++ +++ +QADS + +WIK + ++ A + + + Sbjct: 321 CEDIERRFCFEVVSPTKSCMLQADSEKLRQAWIKAVQTSI-ATAYREKGDESEKLDKKSS 379 Query: 318 PGSSSLSSGPNS 329 P + SL SG S Sbjct: 380 PSTGSLDSGNES 391 >gi|6912460 GRB2-associated binding protein 2 isoform b [Homo sapiens] Length = 638 Score = 48.9 bits (115), Expect = 9e-06 Identities = 41/146 (28%), Positives = 65/146 (44%), Gaps = 6/146 (4%) Query: 229 YFKCEQDREPLRTIFLKDVLKTHECLVKSGDLLMRDNLFEIITSSRTFYVQADSPEDMHS 288 Y+K + ++PLR I L + L + L +F+I TS RTFY+ A++ EDM+ Sbjct: 10 YYKNDHSKKPLRIINLNFCEQVDAGLTFNKKELQDSFVFDIKTSERTFYLVAETEEDMNK 69 Query: 289 WIKEIGAAVQALKCHPRETSFSRSISLTRPGSSSLSSGPNSILCRGRPPLEEKKALCKAP 348 W++ I + T R++S G S P + + L E+K+ AP Sbjct: 70 WVQSI-CQICGFNQAEESTDSLRNVSSAGHGP---RSSPAELSSSSQHLLRERKS--SAP 123 Query: 349 SVASSWQPWTPVPQAGEKLLPPGDTS 374 S +S +T P + P TS Sbjct: 124 SHSSQPTLFTFEPPVSNHMQPTLSTS 149 >gi|7706643 pleckstrin 2 [Homo sapiens] Length = 353 Score = 48.9 bits (115), Expect = 9e-06 Identities = 33/105 (31%), Positives = 54/105 (51%), Gaps = 8/105 (7%) Query: 199 LIKSGYCVKQGNVRKSWKRRFFALDDFTICYFKCEQDRE---PLRTIFLKDVLKTHECLV 255 ++K G+ VK+G++ +WK R+F L T+ Y+K E R P I L T CL Sbjct: 5 VLKEGFLVKRGHIVHNWKARWFILRQNTLVYYKLEGGRRVTPPKGRILLDGCTITCPCL- 63 Query: 256 KSGDLLMRDNLFEIITSSRT-FYVQADSPEDMHSWIKEIGAAVQA 299 + R L ++ T + T ++++A S E+ +W EI A+ A Sbjct: 64 ---EYENRPLLIKLKTQTSTEYFLEACSREERDAWAFEITGAIHA 105 Score = 45.1 bits (105), Expect = 1e-04 Identities = 33/102 (32%), Positives = 53/102 (51%), Gaps = 7/102 (6%) Query: 199 LIKSGYCVKQGNVRKSWKRRFFAL---DDFTICYFKCEQDREPLRTIFLKDVLKT--HEC 253 ++K GY KQG+ RK+WK R F L F Y +++ P+ L+ L + + Sbjct: 248 VVKQGYLAKQGHKRKNWKVRRFVLRKDPAFLHYYDPSKEENRPVGGFSLRGSLVSALEDN 307 Query: 254 LVKSG-DLLMRDNLFEIITSSRT-FYVQADSPEDMHSWIKEI 293 V +G ++ NLF++IT T +Y+QA S + WI+ I Sbjct: 308 GVPTGVKGNVQGNLFKVITKDDTHYYIQASSKAERAEWIEAI 349 >gi|4758964 cytohesin 1 isoform 1 [Homo sapiens] Length = 398 Score = 48.5 bits (114), Expect = 1e-05 Identities = 37/138 (26%), Positives = 65/138 (47%), Gaps = 25/138 (18%) Query: 201 KSGYCVKQGNVR-KSWKRRFFALDDFTICYFKCEQDRE-----PLRTIFLKDV--LKTHE 252 + G+ +K G R K+WKRR+F L D + YF+ D+E PL + +++V K Sbjct: 263 REGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDSKKPN 322 Query: 253 CLVKSGDLLMRDNLFEIITSSRT-------------FYVQADSPEDMHSWIKEIGAAVQA 299 C +L + DN ++I + +T + + A +PE+ WIK I AA+ Sbjct: 323 CF----ELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEEWIKCIKAAISR 378 Query: 300 LKCHPRETSFSRSISLTR 317 + + + +S T+ Sbjct: 379 DPFYEMLAARKKKVSSTK 396 >gi|93102364 SWAP-70 protein [Homo sapiens] Length = 585 Score = 48.1 bits (113), Expect = 1e-05 Identities = 30/104 (28%), Positives = 50/104 (48%), Gaps = 6/104 (5%) Query: 199 LIKSGYCVKQGNVRKSWKRRFFALDDFTICYFKCEQDREPLRTIFLKDVLKTHECLVKS- 257 ++K GY +K+G+ RK+W R+F L I Y+ E ++ D+L C V+S Sbjct: 211 VLKQGYMMKKGHRRKNWTERWFVLKPNIISYYVSEDLKDK-----KGDILLDENCCVESL 265 Query: 258 GDLLMRDNLFEIITSSRTFYVQADSPEDMHSWIKEIGAAVQALK 301 D + LF + +TF + A + WI+ I + + LK Sbjct: 266 PDKDGKKCLFLVKCFDKTFEISASDKKKKQEWIQAIHSTIHLLK 309 >gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo sapiens] Length = 1054 Score = 47.4 bits (111), Expect = 3e-05 Identities = 50/223 (22%), Positives = 90/223 (40%), Gaps = 21/223 (9%) Query: 79 PFCFVINALSQRYFLQANDQKDMKDWVEALNQASKITVPKGGG-----LPMTTEVLKSLA 133 P CF I A + + A+ + + + W+ LN A I K GG LP T + Sbjct: 818 PHCFTIYAAQKTIVVAASTRLEKEKWMLDLNSA--IQAAKSGGDTAPALPGRTVCTR--- 872 Query: 134 APPALEKKPQVAYKTEIIGGVVVHTPISQNGGDGQEGSEPGSHTILRRSQSYIPTSGCRA 193 PP + + ++E V S G GQ + H R+ S S Sbjct: 873 -PPRSPNEVSLEQESEDDARGVR----SSLEGHGQHRANTTMHVCWYRNTS---VSRADH 924 Query: 194 STGPPLIKSGYCVKQGNVRKSWKRRFFALDDFTICYFKCEQDREPLRTIFLKDVLKTHEC 253 S SGY +++ W++ + +F + ++K QD PL ++ +L Sbjct: 925 SAAVENQLSGYLLRKFKNSHGWQKLWVVFTNFCLFFYKTHQDDYPLASL---PLLGYSVS 981 Query: 254 LVKSGDLLMRDNLFEIITSSRTFYVQADSPEDMHSWIKEIGAA 296 + + D + +D +F++ S ++ +A+S W++ I A Sbjct: 982 IPREADGIHKDYVFKLQFKSHVYFFRAESKYTFERWMEVIQGA 1024 >gi|239047795 pleckstrin homology domain containing, family A member 7 [Homo sapiens] Length = 1121 Score = 47.0 bits (110), Expect = 3e-05 Identities = 33/130 (25%), Positives = 59/130 (45%), Gaps = 24/130 (18%) Query: 192 RASTGPPLIKSGYCVKQGNV-RKSWKRRFFALDDFTICYFKCEQDREPLRTIFLKDVLKT 250 R + P++ G+ KQ + + WKRR+F L D+ + Y+K ++ L +I L + + Sbjct: 158 RRNPNVPVVVRGWLHKQDSSGMRLWKRRWFVLADYCLFYYKDSREEAVLGSIPLPSYVIS 217 Query: 251 HECLVKSGDLLMRDNLFEII--------------------TSSRTFYVQADSPEDMHSWI 290 V D + R F+ + + RT+Y AD+ EDM++W+ Sbjct: 218 P---VAPEDRISRKYSFKAVHTGMRALIYNSSTAGSQAEQSGMRTYYFSADTQEDMNAWV 274 Query: 291 KEIGAAVQAL 300 + + A Q L Sbjct: 275 RAMNQAAQVL 284 Score = 35.4 bits (80), Expect = 0.099 Identities = 25/117 (21%), Positives = 54/117 (46%), Gaps = 16/117 (13%) Query: 12 GFLDIEEHENSGKFLRRYFILDTQANCLLWYMDNPQNLAMGAGAVGALQLTYISKVSIAT 71 G+L ++ + RR+F+L CL +Y D+ + +G+ + + ++ ++ + Sbjct: 169 GWLHKQDSSGMRLWKRRWFVLADY--CLFYYKDSREEAVLGSIPLPSYVISPVAPEDRIS 226 Query: 72 PKQKPKTPF----CFVINALS----------QRYFLQANDQKDMKDWVEALNQASKI 114 K K + N+ + + Y+ A+ Q+DM WV A+NQA+++ Sbjct: 227 RKYSFKAVHTGMRALIYNSSTAGSQAEQSGMRTYYFSADTQEDMNAWVRAMNQAAQV 283 >gi|46370073 GRB2-associated binding protein 1 isoform b [Homo sapiens] Length = 694 Score = 47.0 bits (110), Expect = 3e-05 Identities = 31/108 (28%), Positives = 53/108 (49%), Gaps = 11/108 (10%) Query: 195 TGPPLIKSGYCVKQGNVRK----SWKRRFFAL-------DDFTICYFKCEQDREPLRTIF 243 +G ++ SG+ K +K +WKRR+F L D + Y+K + ++P+R I Sbjct: 2 SGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRIID 61 Query: 244 LKDVLKTHECLVKSGDLLMRDNLFEIITSSRTFYVQADSPEDMHSWIK 291 L + L + +F+I T R FY+ ADS E+M+ W++ Sbjct: 62 LNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVR 109 >gi|46370071 GRB2-associated binding protein 1 isoform a [Homo sapiens] Length = 724 Score = 47.0 bits (110), Expect = 3e-05 Identities = 31/108 (28%), Positives = 53/108 (49%), Gaps = 11/108 (10%) Query: 195 TGPPLIKSGYCVKQGNVRK----SWKRRFFAL-------DDFTICYFKCEQDREPLRTIF 243 +G ++ SG+ K +K +WKRR+F L D + Y+K + ++P+R I Sbjct: 2 SGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRIID 61 Query: 244 LKDVLKTHECLVKSGDLLMRDNLFEIITSSRTFYVQADSPEDMHSWIK 291 L + L + +F+I T R FY+ ADS E+M+ W++ Sbjct: 62 LNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVR 109 >gi|154354979 myosin X [Homo sapiens] Length = 2058 Score = 46.6 bits (109), Expect = 4e-05 Identities = 28/95 (29%), Positives = 50/95 (52%), Gaps = 12/95 (12%) Query: 200 IKSGYCVKQGN-----VRKSWKRRFFALDDFTICYFKCEQDREPLRTIFLKDVLKTHECL 254 +K G+ K+G R++WK+R+F L + YF+ + + + T+ +V E + Sbjct: 1214 LKQGWLHKKGGGSSTLSRRNWKKRWFVLRQSKLMYFENDSEEKLKGTV---EVRTAKEII 1270 Query: 255 VKSGDLLMRDNLFEIITSSRTFYVQADSPEDMHSW 289 D ++N +II + RTF++ A+SPED W Sbjct: 1271 ----DNTTKENGIDIIMADRTFHLIAESPEDASQW 1301 Score = 37.4 bits (85), Expect = 0.026 Identities = 15/28 (53%), Positives = 20/28 (71%) Query: 263 RDNLFEIITSSRTFYVQADSPEDMHSWI 290 R N F IIT++R + AD+PE+MH WI Sbjct: 1349 RPNSFVIITANRVLHCNADTPEEMHHWI 1376 >gi|219689123 pleckstrin homology domain containing, family A member 5 isoform 2 [Homo sapiens] Length = 1105 Score = 46.2 bits (108), Expect = 6e-05 Identities = 28/106 (26%), Positives = 54/106 (50%), Gaps = 5/106 (4%) Query: 188 TSGCRASTGPPLIKSGYCVKQGNV-RKSWKRRFFALDDFTICYFKCEQDREPLRTIFLKD 246 ++ + + P+++ G+ KQ + K WK+R+F L D + Y++ E++ L +I L Sbjct: 51 SNSIKRNPNAPVVRRGWLYKQDSTGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPS 110 Query: 247 VLKTHECLVKSGDLLMRDNLFEII-TSSRTFYVQADSPEDMHSWIK 291 L+ S D + R F+ + RT+Y D+ ++M W+K Sbjct: 111 F---QIALLTSEDHINRKYAFKAAHPNMRTYYFCTDTGKEMELWMK 153 >gi|19923493 pleckstrin homology domain containing, family A member 5 isoform 1 [Homo sapiens] Length = 1116 Score = 46.2 bits (108), Expect = 6e-05 Identities = 28/106 (26%), Positives = 54/106 (50%), Gaps = 5/106 (4%) Query: 188 TSGCRASTGPPLIKSGYCVKQGNV-RKSWKRRFFALDDFTICYFKCEQDREPLRTIFLKD 246 ++ + + P+++ G+ KQ + K WK+R+F L D + Y++ E++ L +I L Sbjct: 159 SNSIKRNPNAPVVRRGWLYKQDSTGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPS 218 Query: 247 VLKTHECLVKSGDLLMRDNLFEII-TSSRTFYVQADSPEDMHSWIK 291 L+ S D + R F+ + RT+Y D+ ++M W+K Sbjct: 219 F---QIALLTSEDHINRKYAFKAAHPNMRTYYFCTDTGKEMELWMK 261 >gi|25777598 diacylglycerol kinase, delta 130kDa isoform 2 [Homo sapiens] Length = 1214 Score = 46.2 bits (108), Expect = 6e-05 Identities = 42/133 (31%), Positives = 61/133 (45%), Gaps = 14/133 (10%) Query: 159 PISQNGGDGQEGSEPGSHTILRRSQSYIPTSG-CRASTGPPLIKSGYCVKQGNVRKSWKR 217 P + D + +EPGS L R S TSG R T +IK G KQ N + KR Sbjct: 19 PPPEESSDSEPEAEPGSPQKLIRKVS---TSGQIRQKT---IIKEGMLTKQNNSFQRSKR 72 Query: 218 RFFALDDFTICYFKCEQDREPLRTIFLKDVLKTHECLVKSGDLLMRDNLFEIITSSRTFY 277 R+F L T+ Y K ++I +V T + +S + +N F +IT R Sbjct: 73 RYFKLRGRTLYYAK------TAKSIIFDEVDLTDASVAESSTKNV-NNSFTVITPCRKLI 125 Query: 278 VQADSPEDMHSWI 290 + AD+ ++M WI Sbjct: 126 LCADNRKEMEDWI 138 >gi|38201692 RAS p21 protein activator 3 [Homo sapiens] Length = 834 Score = 45.4 bits (106), Expect = 1e-04 Identities = 27/99 (27%), Positives = 54/99 (54%), Gaps = 9/99 (9%) Query: 197 PPLIKSGYCVKQGNVRK-----SWKRRFFALDDFTICYFKCEQDREPLRTIFLKDVLKTH 251 P ++K G+ +K+ RK ++K+R+F L + Y K + D +PL +I ++++L Sbjct: 575 PIVLKEGFMIKRAQGRKRFGMKNFKKRWFRLTNHEFTYHKSKGD-QPLYSIPIENILAVE 633 Query: 252 ECLVKSGDLLMRDNLFEIITSSRTFYVQADSPEDMHSWI 290 + +S + N+F++I R Y+QA++ + WI Sbjct: 634 KLEEESFKM---KNMFQVIQPERALYIQANNCVEAKDWI 669 >gi|24432056 hypothetical protein LOC144717 [Homo sapiens] Length = 249 Score = 45.4 bits (106), Expect = 1e-04 Identities = 49/198 (24%), Positives = 82/198 (41%), Gaps = 15/198 (7%) Query: 193 ASTGPPLIKSGYCVKQGNVRKSWKRRFFALDDFTICYFKCEQDREPLRTIFLKDVLKTHE 252 A+ P+ +G+ K+G ++ RR+F L + YF+ REP+ I L+ T E Sbjct: 12 ATCDAPVDNAGFLYKKGGRHAAYHRRWFVLRGNMLFYFEDAASREPVGVIILEGC--TVE 69 Query: 253 CLVKSGDLLMRDNLFEIITSSRTFYVQADSPEDMHSWIKEIG-AAVQALKCHPRETSFSR 311 + + + T +RT+ + A+S + M W+K + A+ L+ RE + Sbjct: 70 LVEAAEEFAFAVRFAG--TRARTYVLAAESQDAMEGWVKALSRASFDYLRLVVRE--LEQ 125 Query: 312 SISLTRPGSSSLSSGPNSILCRGRPPLEEKKALCKAPSVASSWQPWTPVP-QAGEKLLPP 370 ++ R G P P L AL PS+ S+ P +P LPP Sbjct: 126 QLAAVRGGGGMALPQPQPQSLPLPPSL--PSALAPVPSLPSAPAPVPALPLPRRPSALPP 183 Query: 371 GDT-----SEDSLFTPRP 383 + S ++ F P P Sbjct: 184 KENGCAVWSTEATFRPGP 201 >gi|4758968 cytohesin 3 [Homo sapiens] Length = 399 Score = 45.1 bits (105), Expect = 1e-04 Identities = 28/119 (23%), Positives = 50/119 (42%), Gaps = 28/119 (23%) Query: 201 KSGYCVKQGNVRKSWKRRFFALDDFTICYFKCEQDREPLRTIFLKDVLKTHECLVKSGDL 260 + G+ +K G K+WKRR+F L D + YF+ D+EP + ++ ++ + Sbjct: 267 REGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEP------RGIIPLENLSIREVED 320 Query: 261 LMRDNLFEIITSSR----------------------TFYVQADSPEDMHSWIKEIGAAV 297 + N FE+ S + + A SPE+ W+K I A++ Sbjct: 321 PRKPNCFELYNPSHKGQVIKACKTEADGRVVEGNHVVYRISAPSPEEKEEWMKSIKASI 379 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.317 0.134 0.410 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 19,050,605 Number of Sequences: 37866 Number of extensions: 984609 Number of successful extensions: 3617 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 69 Number of HSP's successfully gapped in prelim test: 129 Number of HSP's that attempted gapping in prelim test: 3373 Number of HSP's gapped (non-prelim): 321 length of query: 425 length of database: 18,247,518 effective HSP length: 105 effective length of query: 320 effective length of database: 14,271,588 effective search space: 4566908160 effective search space used: 4566908160 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.