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Search of human proteins with 153946421
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|153946421 endoplasmic reticulum to nucleus signalling 1
[Homo sapiens]
(977 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|153946421 endoplasmic reticulum to nucleus signalling 1 [Homo... 1982 0.0
gi|145312265 endoplasmic reticulum to nucleus signalling 2 [Homo... 853 0.0
gi|212549756 calcium/calmodulin-dependent protein kinase II delt... 94 6e-19
gi|26667183 calcium/calmodulin-dependent protein kinase II delta... 94 6e-19
gi|212549753 calcium/calmodulin-dependent protein kinase II delt... 94 6e-19
gi|26667186 calcium/calmodulin-dependent protein kinase II delta... 94 6e-19
gi|26667189 calcium/calmodulin-dependent protein kinase II delta... 94 6e-19
gi|26667180 calcium/calmodulin-dependent protein kinase II delta... 94 6e-19
gi|4505785 phosphorylase kinase, gamma 2 (testis) [Homo sapiens] 93 1e-18
gi|25952118 calcium/calmodulin-dependent protein kinase II alpha... 92 2e-18
gi|25952114 calcium/calmodulin-dependent protein kinase II alpha... 92 2e-18
gi|26667199 calcium/calmodulin-dependent protein kinase II gamma... 91 5e-18
gi|21359873 polo-like kinase 1 [Homo sapiens] 91 5e-18
gi|26667191 calcium/calmodulin-dependent protein kinase II gamma... 91 5e-18
gi|26667211 calcium/calmodulin-dependent protein kinase II gamma... 91 5e-18
gi|26667203 calcium/calmodulin-dependent protein kinase II gamma... 91 5e-18
gi|26667196 calcium/calmodulin-dependent protein kinase II gamma... 91 5e-18
gi|26051204 calcium/calmodulin-dependent protein kinase II beta ... 90 9e-18
gi|26051210 calcium/calmodulin-dependent protein kinase II beta ... 90 9e-18
gi|26051214 calcium/calmodulin-dependent protein kinase II beta ... 90 9e-18
gi|26051206 calcium/calmodulin-dependent protein kinase II beta ... 90 9e-18
gi|26051216 calcium/calmodulin-dependent protein kinase II beta ... 90 9e-18
gi|26051218 calcium/calmodulin-dependent protein kinase II beta ... 90 9e-18
gi|26051212 calcium/calmodulin-dependent protein kinase II beta ... 90 9e-18
gi|26051208 calcium/calmodulin-dependent protein kinase II beta ... 90 9e-18
gi|5453882 phosphorylase kinase gamma subunit 1 [Homo sapiens] 90 9e-18
gi|120659787 protein kinase D2 isoform B [Homo sapiens] 89 2e-17
gi|120659785 protein kinase D2 isoform A [Homo sapiens] 89 2e-17
gi|120659782 protein kinase D2 isoform A [Homo sapiens] 89 2e-17
gi|19923468 protein kinase D2 isoform A [Homo sapiens] 89 2e-17
>gi|153946421 endoplasmic reticulum to nucleus signalling 1 [Homo
sapiens]
Length = 977
Score = 1982 bits (5136), Expect = 0.0
Identities = 977/977 (100%), Positives = 977/977 (100%)
Query: 1 MPARRLLLLLTLLLPGLGIFGSTSTVTLPETLLFVSTLDGSLHAVSKRTGSIKWTLKEDP 60
MPARRLLLLLTLLLPGLGIFGSTSTVTLPETLLFVSTLDGSLHAVSKRTGSIKWTLKEDP
Sbjct: 1 MPARRLLLLLTLLLPGLGIFGSTSTVTLPETLLFVSTLDGSLHAVSKRTGSIKWTLKEDP 60
Query: 61 VLQVPTHVEEPAFLPDPNDGSLYTLGSKNNEGLTKLPFTIPELVQASPCRSSDGILYMGK 120
VLQVPTHVEEPAFLPDPNDGSLYTLGSKNNEGLTKLPFTIPELVQASPCRSSDGILYMGK
Sbjct: 61 VLQVPTHVEEPAFLPDPNDGSLYTLGSKNNEGLTKLPFTIPELVQASPCRSSDGILYMGK 120
Query: 121 KQDIWYVIDLLTGEKQQTLSSAFADSLCPSTSLLYLGRTEYTITMYDTKTRELRWNATYF 180
KQDIWYVIDLLTGEKQQTLSSAFADSLCPSTSLLYLGRTEYTITMYDTKTRELRWNATYF
Sbjct: 121 KQDIWYVIDLLTGEKQQTLSSAFADSLCPSTSLLYLGRTEYTITMYDTKTRELRWNATYF 180
Query: 181 DYAASLPEDDVDYKMSHFVSNGDGLVVTVDSESGDVLWIQNYASPVVAFYVWQREGLRKV 240
DYAASLPEDDVDYKMSHFVSNGDGLVVTVDSESGDVLWIQNYASPVVAFYVWQREGLRKV
Sbjct: 181 DYAASLPEDDVDYKMSHFVSNGDGLVVTVDSESGDVLWIQNYASPVVAFYVWQREGLRKV 240
Query: 241 MHINVAVETLRYLTFMSGEVGRITKWKYPFPKETEAKSKLTPTLYVGKYSTSLYASPSMV 300
MHINVAVETLRYLTFMSGEVGRITKWKYPFPKETEAKSKLTPTLYVGKYSTSLYASPSMV
Sbjct: 241 MHINVAVETLRYLTFMSGEVGRITKWKYPFPKETEAKSKLTPTLYVGKYSTSLYASPSMV 300
Query: 301 HEGVAVVPRGSTLPLLEGPQTDGVTIGDKGECVITPSTDVKFDPGLKSKNKLNYLRNYWL 360
HEGVAVVPRGSTLPLLEGPQTDGVTIGDKGECVITPSTDVKFDPGLKSKNKLNYLRNYWL
Sbjct: 301 HEGVAVVPRGSTLPLLEGPQTDGVTIGDKGECVITPSTDVKFDPGLKSKNKLNYLRNYWL 360
Query: 361 LIGHHETPLSASTKMLERFPNNLPKHRENVIPADSEKKSFEEVINLVDQTSENAPTTVSR 420
LIGHHETPLSASTKMLERFPNNLPKHRENVIPADSEKKSFEEVINLVDQTSENAPTTVSR
Sbjct: 361 LIGHHETPLSASTKMLERFPNNLPKHRENVIPADSEKKSFEEVINLVDQTSENAPTTVSR 420
Query: 421 DVEEKPAHAPARPEAPVDSMLKDMATIILSTFLLIGWVAFIITYPLSMHQQQQLQHQQFQ 480
DVEEKPAHAPARPEAPVDSMLKDMATIILSTFLLIGWVAFIITYPLSMHQQQQLQHQQFQ
Sbjct: 421 DVEEKPAHAPARPEAPVDSMLKDMATIILSTFLLIGWVAFIITYPLSMHQQQQLQHQQFQ 480
Query: 481 KELEKIQLLQQQQQQLPFHPPGDTAQDGELLDTSGPYSESSGTSSPSTSPRASNHSLCSG 540
KELEKIQLLQQQQQQLPFHPPGDTAQDGELLDTSGPYSESSGTSSPSTSPRASNHSLCSG
Sbjct: 481 KELEKIQLLQQQQQQLPFHPPGDTAQDGELLDTSGPYSESSGTSSPSTSPRASNHSLCSG 540
Query: 541 SSASKAGSSPSLEQDDGDEETSVVIVGKISFCPKDVLGHGAEGTIVYRGMFDNRDVAVKR 600
SSASKAGSSPSLEQDDGDEETSVVIVGKISFCPKDVLGHGAEGTIVYRGMFDNRDVAVKR
Sbjct: 541 SSASKAGSSPSLEQDDGDEETSVVIVGKISFCPKDVLGHGAEGTIVYRGMFDNRDVAVKR 600
Query: 601 ILPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAH 660
ILPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAH
Sbjct: 601 ILPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAH 660
Query: 661 LGLEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAV 720
LGLEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAV
Sbjct: 661 LGLEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAV 720
Query: 721 GRHSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQ 780
GRHSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQ
Sbjct: 721 GRHSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQ 780
Query: 781 RQANILLGACSLDCLHPEKHEDVIARELIEKMIAMDPQKRPSAKHVLKHPFFWSLEKQLQ 840
RQANILLGACSLDCLHPEKHEDVIARELIEKMIAMDPQKRPSAKHVLKHPFFWSLEKQLQ
Sbjct: 781 RQANILLGACSLDCLHPEKHEDVIARELIEKMIAMDPQKRPSAKHVLKHPFFWSLEKQLQ 840
Query: 841 FFQDVSDRIEKESLDGPIVKQLERGGRAVVKMDWRENITVPLQTDLRKFRTYKGGSVRDL 900
FFQDVSDRIEKESLDGPIVKQLERGGRAVVKMDWRENITVPLQTDLRKFRTYKGGSVRDL
Sbjct: 841 FFQDVSDRIEKESLDGPIVKQLERGGRAVVKMDWRENITVPLQTDLRKFRTYKGGSVRDL 900
Query: 901 LRAMRNKKHHYRELPAEVRETLGSLPDDFVCYFTSRFPHLLAHTYRAMELCSHERLFQPY 960
LRAMRNKKHHYRELPAEVRETLGSLPDDFVCYFTSRFPHLLAHTYRAMELCSHERLFQPY
Sbjct: 901 LRAMRNKKHHYRELPAEVRETLGSLPDDFVCYFTSRFPHLLAHTYRAMELCSHERLFQPY 960
Query: 961 YFHEPPEPQPPVTPDAL 977
YFHEPPEPQPPVTPDAL
Sbjct: 961 YFHEPPEPQPPVTPDAL 977
>gi|145312265 endoplasmic reticulum to nucleus signalling 2 [Homo
sapiens]
Length = 974
Score = 853 bits (2203), Expect = 0.0
Identities = 486/979 (49%), Positives = 610/979 (62%), Gaps = 84/979 (8%)
Query: 2 PARRLLLLLTLLLPGLGIFGSTSTVTLPETLLFVSTLDGSLHAVSKRTGSIKWTLKEDPV 61
P RL L L LG PE LL VSTLDGSLHA+SK+TG +KWTL++DPV
Sbjct: 58 PWPRLGLQLQFAALLLGTLSPQVHTLRPENLLLVSTLDGSLHALSKQTGDLKWTLRDDPV 117
Query: 62 LQVPTHVEEPAFLPDPNDGSLYTLGSKNNEGLTKLPFTIPELVQASPCRSSDGILYMGKK 121
++ P +V E AFL DP DGSLY LG++ +GL KLPFTIPELV ASPCRSSDG+ Y G+K
Sbjct: 118 IEGPMYVTEMAFLSDPADGSLYILGTQKQQGLMKLPFTIPELVHASPCRSSDGVFYTGRK 177
Query: 122 QDIWYVIDLLTGEKQQTLSSAFADSLCPSTSLLYLGRTEYTITMYDTKTRELRWNATYFD 181
QD W+V+D +GE Q TL++ PST LY+GRT+YT+TM+D + LRWN TY
Sbjct: 178 QDAWFVVDPESGETQMTLTTEG-----PSTPRLYIGRTQYTVTMHDPRAPALRWNTTYRR 232
Query: 182 YAASLPEDDVDYKMSHFVSNGDGLVVTVDSESGDVLWIQNYASPVVAFYVWQREGLRKVM 241
Y+A + MSH S G GL++TVD SG VLW Q+ PV+ Y W ++GLR++
Sbjct: 233 YSAPPMDGSPGKYMSHLASCGMGLLLTVDPGSGTVLWTQDLGVPVMGVYTWHQDGLRQLP 292
Query: 242 HINVAVETLRYLTFMSGEVGRITKWKYPFPKETEA-----KSKLTPTLYVGKYSTSLYAS 296
H+ +A +TL +L G + + P++T ++L TLYVGK T Y S
Sbjct: 293 HLTLARDTLHFLALRWGHI----RLPASGPRDTATLFSTLDTQLLMTLYVGKDETGFYVS 348
Query: 297 PSMVHEGVAVVPRGSTLPLLEGPQTDGVTIGDKGECVITPSTDVKFDPGLKSKNKLNYLR 356
++VH GVA+VPRG TL +GP TD VT+ GE +PST V++ G + L
Sbjct: 349 KALVHTGVALVPRGLTLAPADGPTTDEVTLQVSGEREGSPSTAVRYPSGSVA------LP 402
Query: 357 NYWLLIGHHETPLSASTKMLERFPNNLPKHRENVIPADSEKKSFEEVINLVDQTSENAPT 416
+ WLLIGHHE P T ML P E P +++ +F + L+ + E
Sbjct: 403 SQWLLIGHHELPPVLHTTMLRVHPTLGSGTAETRPPENTQAPAF--FLELLSLSREKLWD 460
Query: 417 TVSRDVEEKPAHAPARPEAPVDSML----KDMATIILSTFLLIGWVAFIITYPLSMHQQQ 472
+ E+ P DS L +D+ L+ LL GW+ F++ +QQ
Sbjct: 461 SELHPEEKTP-----------DSYLGLGPQDLLAASLTAVLLGGWILFVM-------RQQ 502
Query: 473 QLQHQQFQKELEKIQLLQQQQQQLPFHPP--GDTAQDGELLDTSGPYSESSGTSSPSTSP 530
Q Q + ++QQ+ P P +QD + L SG S
Sbjct: 503 QPQ-------------VVEKQQETPLAPADFAHISQDAQSLH--------SGAS------ 535
Query: 531 RASNHSLCSGSSASKAGSSPSLEQDDGDEETSVVIVGKISFCPKDVLGHGAEGTIVYRGM 590
R S L S S ++ P EQ + +VGKISF PKDVLG GA GT V+RG
Sbjct: 536 RRSQKRLQSPSKQAQPLDDPEAEQ--------LTVVGKISFNPKDVLGRGAGGTFVFRGQ 587
Query: 591 FDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQ 650
F+ R VAVKR+L ECF REVQLL+ESD HPNV+RYFCTE+ QF YIA+ELC A+LQ
Sbjct: 588 FEGRAVAVKRLLRECFGLVRREVQLLQESDRHPNVLRYFCTERGPQFHYIALELCRASLQ 647
Query: 651 EYVEQKDFAHLGLEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMIS 710
EYVE D GLEP +LQQ SGLAHLHSL+IVHRDLKP NILI+ P++ G + ++S
Sbjct: 648 EYVENPDLDRGGLEPEVVLQQLMSGLAHLHSLHIVHRDLKPGNILITGPDSQGLGRVVLS 707
Query: 711 DFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISE 770
DFGLCKKL GR SFS SG+PGTEGW+APE+L ++PT VDIFSAGCVFYYV+S
Sbjct: 708 DFGLCKKLPAGRCSFSLHSGIPGTEGWMAPELLQLLPPDSPTSAVDIFSAGCVFYYVLSG 767
Query: 771 GSHPFGKSLQRQANILLGACSLDCLHPEKHEDVIARELIEKMIAMDPQKRPSAKHVLKHP 830
GSHPFG SL RQANIL GA L L E H+ V+AR+L+ M++ PQ RPSA VL HP
Sbjct: 768 GSHPFGDSLYRQANILTGAPCLAHLEEEVHDKVVARDLVGAMLSPLPQPRPSAPQVLAHP 827
Query: 831 FFWSLEKQLQFFQDVSDRIEKESLDGPIVKQLERGGRAVVKMDWRENITVPLQTDLRKFR 890
FFWS KQLQFFQDVSD +EKES P+V+ LE GG AVV+ +W E+I++PLQTDLRKFR
Sbjct: 828 FFWSRAKQLQFFQDVSDWLEKESEQEPLVRALEAGGCAVVRDNWHEHISMPLQTDLRKFR 887
Query: 891 TYKGGSVRDLLRAMRNKKHHYRELPAEVRETLGSLPDDFVCYFTSRFPHLLAHTYRAMEL 950
+YKG SVRDLLRA+RNKKHHYRELP EVR+ LG +PD FV YFT+RFP LL HT+RAM
Sbjct: 888 SYKGTSVRDLLRAVRNKKHHYRELPVEVRQALGQVPDGFVQYFTNRFPRLLLHTHRAMRS 947
Query: 951 CSHERLFQPYYFHEPPEPQ 969
C+ E LF PYY PP+ +
Sbjct: 948 CASESLFLPYY---PPDSE 963
>gi|212549756 calcium/calmodulin-dependent protein kinase II delta
isoform 4 [Homo sapiens]
Length = 489
Score = 94.0 bits (232), Expect = 6e-19
Identities = 69/232 (29%), Positives = 117/232 (50%), Gaps = 29/232 (12%)
Query: 610 DREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAA-------TLQEYVEQKDFAHLG 662
+RE ++ R +HPN++R + + F Y+ +L +EY + D +H
Sbjct: 59 EREARICRLL-KHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHC- 116
Query: 663 LEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGR 722
+QQ + H H IVHRDLKP N+L++ + +K ++DFGL ++ +
Sbjct: 117 ------IQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVK--LADFGLAIEVQGDQ 168
Query: 723 HSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQ 782
++ G GT G+++PE+L +D P VD+++ G V Y++ G PF Q +
Sbjct: 169 QAW---FGFAGTPGYLSPEVLRKDPYGKP---VDMWACG-VILYILLVGYPPFWDEDQHR 221
Query: 783 ANILLGACSLDCLHPEKHEDVI---ARELIEKMIAMDPQKRPSAKHVLKHPF 831
+ A + D PE D + A++LI KM+ ++P KR +A LKHP+
Sbjct: 222 LYQQIKAGAYDFPSPE--WDTVTPEAKDLINKMLTINPAKRITASEALKHPW 271
>gi|26667183 calcium/calmodulin-dependent protein kinase II delta
isoform 1 [Homo sapiens]
Length = 478
Score = 94.0 bits (232), Expect = 6e-19
Identities = 69/232 (29%), Positives = 117/232 (50%), Gaps = 29/232 (12%)
Query: 610 DREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAA-------TLQEYVEQKDFAHLG 662
+RE ++ R +HPN++R + + F Y+ +L +EY + D +H
Sbjct: 59 EREARICRLL-KHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHC- 116
Query: 663 LEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGR 722
+QQ + H H IVHRDLKP N+L++ + +K ++DFGL ++ +
Sbjct: 117 ------IQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVK--LADFGLAIEVQGDQ 168
Query: 723 HSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQ 782
++ G GT G+++PE+L +D P VD+++ G V Y++ G PF Q +
Sbjct: 169 QAW---FGFAGTPGYLSPEVLRKDPYGKP---VDMWACG-VILYILLVGYPPFWDEDQHR 221
Query: 783 ANILLGACSLDCLHPEKHEDVI---ARELIEKMIAMDPQKRPSAKHVLKHPF 831
+ A + D PE D + A++LI KM+ ++P KR +A LKHP+
Sbjct: 222 LYQQIKAGAYDFPSPE--WDTVTPEAKDLINKMLTINPAKRITASEALKHPW 271
>gi|212549753 calcium/calmodulin-dependent protein kinase II delta
isoform 5 [Homo sapiens]
Length = 492
Score = 94.0 bits (232), Expect = 6e-19
Identities = 69/232 (29%), Positives = 117/232 (50%), Gaps = 29/232 (12%)
Query: 610 DREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAA-------TLQEYVEQKDFAHLG 662
+RE ++ R +HPN++R + + F Y+ +L +EY + D +H
Sbjct: 59 EREARICRLL-KHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHC- 116
Query: 663 LEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGR 722
+QQ + H H IVHRDLKP N+L++ + +K ++DFGL ++ +
Sbjct: 117 ------IQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVK--LADFGLAIEVQGDQ 168
Query: 723 HSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQ 782
++ G GT G+++PE+L +D P VD+++ G V Y++ G PF Q +
Sbjct: 169 QAW---FGFAGTPGYLSPEVLRKDPYGKP---VDMWACG-VILYILLVGYPPFWDEDQHR 221
Query: 783 ANILLGACSLDCLHPEKHEDVI---ARELIEKMIAMDPQKRPSAKHVLKHPF 831
+ A + D PE D + A++LI KM+ ++P KR +A LKHP+
Sbjct: 222 LYQQIKAGAYDFPSPE--WDTVTPEAKDLINKMLTINPAKRITASEALKHPW 271
>gi|26667186 calcium/calmodulin-dependent protein kinase II delta
isoform 1 [Homo sapiens]
Length = 478
Score = 94.0 bits (232), Expect = 6e-19
Identities = 69/232 (29%), Positives = 117/232 (50%), Gaps = 29/232 (12%)
Query: 610 DREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAA-------TLQEYVEQKDFAHLG 662
+RE ++ R +HPN++R + + F Y+ +L +EY + D +H
Sbjct: 59 EREARICRLL-KHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHC- 116
Query: 663 LEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGR 722
+QQ + H H IVHRDLKP N+L++ + +K ++DFGL ++ +
Sbjct: 117 ------IQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVK--LADFGLAIEVQGDQ 168
Query: 723 HSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQ 782
++ G GT G+++PE+L +D P VD+++ G V Y++ G PF Q +
Sbjct: 169 QAW---FGFAGTPGYLSPEVLRKDPYGKP---VDMWACG-VILYILLVGYPPFWDEDQHR 221
Query: 783 ANILLGACSLDCLHPEKHEDVI---ARELIEKMIAMDPQKRPSAKHVLKHPF 831
+ A + D PE D + A++LI KM+ ++P KR +A LKHP+
Sbjct: 222 LYQQIKAGAYDFPSPE--WDTVTPEAKDLINKMLTINPAKRITASEALKHPW 271
>gi|26667189 calcium/calmodulin-dependent protein kinase II delta
isoform 2 [Homo sapiens]
Length = 478
Score = 94.0 bits (232), Expect = 6e-19
Identities = 69/232 (29%), Positives = 117/232 (50%), Gaps = 29/232 (12%)
Query: 610 DREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAA-------TLQEYVEQKDFAHLG 662
+RE ++ R +HPN++R + + F Y+ +L +EY + D +H
Sbjct: 59 EREARICRLL-KHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHC- 116
Query: 663 LEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGR 722
+QQ + H H IVHRDLKP N+L++ + +K ++DFGL ++ +
Sbjct: 117 ------IQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVK--LADFGLAIEVQGDQ 168
Query: 723 HSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQ 782
++ G GT G+++PE+L +D P VD+++ G V Y++ G PF Q +
Sbjct: 169 QAW---FGFAGTPGYLSPEVLRKDPYGKP---VDMWACG-VILYILLVGYPPFWDEDQHR 221
Query: 783 ANILLGACSLDCLHPEKHEDVI---ARELIEKMIAMDPQKRPSAKHVLKHPF 831
+ A + D PE D + A++LI KM+ ++P KR +A LKHP+
Sbjct: 222 LYQQIKAGAYDFPSPE--WDTVTPEAKDLINKMLTINPAKRITASEALKHPW 271
>gi|26667180 calcium/calmodulin-dependent protein kinase II delta
isoform 3 [Homo sapiens]
Length = 499
Score = 94.0 bits (232), Expect = 6e-19
Identities = 69/232 (29%), Positives = 117/232 (50%), Gaps = 29/232 (12%)
Query: 610 DREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAA-------TLQEYVEQKDFAHLG 662
+RE ++ R +HPN++R + + F Y+ +L +EY + D +H
Sbjct: 59 EREARICRLL-KHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHC- 116
Query: 663 LEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGR 722
+QQ + H H IVHRDLKP N+L++ + +K ++DFGL ++ +
Sbjct: 117 ------IQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVK--LADFGLAIEVQGDQ 168
Query: 723 HSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQ 782
++ G GT G+++PE+L +D P VD+++ G V Y++ G PF Q +
Sbjct: 169 QAW---FGFAGTPGYLSPEVLRKDPYGKP---VDMWACG-VILYILLVGYPPFWDEDQHR 221
Query: 783 ANILLGACSLDCLHPEKHEDVI---ARELIEKMIAMDPQKRPSAKHVLKHPF 831
+ A + D PE D + A++LI KM+ ++P KR +A LKHP+
Sbjct: 222 LYQQIKAGAYDFPSPE--WDTVTPEAKDLINKMLTINPAKRITASEALKHPW 271
>gi|4505785 phosphorylase kinase, gamma 2 (testis) [Homo sapiens]
Length = 406
Score = 93.2 bits (230), Expect = 1e-18
Identities = 80/294 (27%), Positives = 138/294 (46%), Gaps = 36/294 (12%)
Query: 573 PKDVLGHGAEGTI---VYRGMFDN-----RDVAVKRILPECFS----FADREVQLLRESD 620
PKDV+G G + V+R +V +R+ PE RE +LR+
Sbjct: 26 PKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILRQVA 85
Query: 621 EHPNVIRYFCTEKDRQFQYIAIELCA-ATLQEYVEQKDFAHLGLEPITLLQQTTSGLAHL 679
HP++I + + F ++ +L L +Y+ +K A E ++++ ++ L
Sbjct: 86 GHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEK-VALSEKETRSIMRSLLEAVSFL 144
Query: 680 HSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIA 739
H+ NIVHRDLKP NIL+ ++ +SDFG L G + + GT G++A
Sbjct: 145 HANNIVHRDLKPENILLD-----DNMQIRLSDFGFSCHLEPG----EKLRELCGTPGYLA 195
Query: 740 PEMLSEDCKE-NPTY--TVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGACSLDCLH 796
PE+L E +P Y VD+++ G + + +++ GS PF Q ++
Sbjct: 196 PEILKCSMDETHPGYGKEVDLWACGVILFTLLA-GSPPFWHRRQILMLRMIMEGQYQFSS 254
Query: 797 PE-KHEDVIARELIEKMIAMDPQKRPSAKHVLKHPFF--------WSLEKQLQF 841
PE ++LI +++ +DP+ R +A+ L+HPFF W+L + +F
Sbjct: 255 PEWDDRSSTVKDLISRLLQVDPEARLTAEQALQHPFFERCEGSQPWNLTPRQRF 308
>gi|25952118 calcium/calmodulin-dependent protein kinase II alpha
isoform 2 [Homo sapiens]
Length = 478
Score = 92.0 bits (227), Expect = 2e-18
Identities = 67/232 (28%), Positives = 116/232 (50%), Gaps = 29/232 (12%)
Query: 610 DREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAA-------TLQEYVEQKDFAHLG 662
+RE ++ R +HPN++R + + Y+ +L +EY + D +H
Sbjct: 58 EREARICRLL-KHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHC- 115
Query: 663 LEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGR 722
+QQ + H H + +VHRDLKP N+L++ +K ++DFGL ++ +
Sbjct: 116 ------IQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVK--LADFGLAIEVEGEQ 167
Query: 723 HSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQ 782
++ G GT G+++PE+L +D P VD+++ G V Y++ G PF Q +
Sbjct: 168 QAW---FGFAGTPGYLSPEVLRKDPYGKP---VDLWACG-VILYILLVGYPPFWDEDQHR 220
Query: 783 ANILLGACSLDCLHPEKHEDVI---ARELIEKMIAMDPQKRPSAKHVLKHPF 831
+ A + D PE D + A++LI KM+ ++P KR +A LKHP+
Sbjct: 221 LYQQIKAGAYDFPSPE--WDTVTPEAKDLINKMLTINPSKRITAAEALKHPW 270
>gi|25952114 calcium/calmodulin-dependent protein kinase II alpha
isoform 1 [Homo sapiens]
Length = 489
Score = 92.0 bits (227), Expect = 2e-18
Identities = 67/232 (28%), Positives = 116/232 (50%), Gaps = 29/232 (12%)
Query: 610 DREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAA-------TLQEYVEQKDFAHLG 662
+RE ++ R +HPN++R + + Y+ +L +EY + D +H
Sbjct: 58 EREARICRLL-KHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHC- 115
Query: 663 LEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGR 722
+QQ + H H + +VHRDLKP N+L++ +K ++DFGL ++ +
Sbjct: 116 ------IQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVK--LADFGLAIEVEGEQ 167
Query: 723 HSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQ 782
++ G GT G+++PE+L +D P VD+++ G V Y++ G PF Q +
Sbjct: 168 QAW---FGFAGTPGYLSPEVLRKDPYGKP---VDLWACG-VILYILLVGYPPFWDEDQHR 220
Query: 783 ANILLGACSLDCLHPEKHEDVI---ARELIEKMIAMDPQKRPSAKHVLKHPF 831
+ A + D PE D + A++LI KM+ ++P KR +A LKHP+
Sbjct: 221 LYQQIKAGAYDFPSPE--WDTVTPEAKDLINKMLTINPSKRITAAEALKHPW 270
>gi|26667199 calcium/calmodulin-dependent protein kinase II gamma
isoform 3 [Homo sapiens]
Length = 518
Score = 90.9 bits (224), Expect = 5e-18
Identities = 68/232 (29%), Positives = 116/232 (50%), Gaps = 29/232 (12%)
Query: 610 DREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAA-------TLQEYVEQKDFAHLG 662
+RE ++ R +HPN++R + + F Y+ +L +EY + D +H
Sbjct: 59 EREARICRLL-KHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHC- 116
Query: 663 LEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGR 722
+ Q + H+H +IVHRDLKP N+L++ +K ++DFGL ++ +
Sbjct: 117 ------IHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVK--LADFGLAIEVQGEQ 168
Query: 723 HSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQ 782
++ G GT G+++PE+L +D P VDI++ G V Y++ G PF Q +
Sbjct: 169 QAW---FGFAGTPGYLSPEVLRKDPYGKP---VDIWACG-VILYILLVGYPPFWDEDQHK 221
Query: 783 ANILLGACSLDCLHPEKHEDVI---ARELIEKMIAMDPQKRPSAKHVLKHPF 831
+ A + D PE D + A+ LI +M+ ++P KR +A LKHP+
Sbjct: 222 LYQQIKAGAYDFPSPE--WDTVTPEAKNLINQMLTINPAKRITADQALKHPW 271
>gi|21359873 polo-like kinase 1 [Homo sapiens]
Length = 603
Score = 90.9 bits (224), Expect = 5e-18
Identities = 66/249 (26%), Positives = 117/249 (46%), Gaps = 21/249 (8%)
Query: 592 DNRDVAVKRILPECFSFADREVQLL------RESDEHPNVIRYFCTEKDRQFQYIAIELC 645
D ++V +I+P+ + + + S H +V+ + +D F ++ +ELC
Sbjct: 74 DTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELC 133
Query: 646 AATLQEYVEQKDFAHLGLEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKI 705
+ ++ A E L+Q G +LH ++HRDLK N+ ++ +
Sbjct: 134 RRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNED-----L 188
Query: 706 KAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFY 765
+ I DFGL K+ + R+ + GT +IAPE+LS K+ ++ VD++S GC+ Y
Sbjct: 189 EVKIGDFGLATKV---EYDGERKKTLCGTPNYIAPEVLS---KKGHSFEVDVWSIGCIMY 242
Query: 766 YVISEGSHPFGKSLQRQANILLGACSLDCLHPEKHEDVIARELIEKMIAMDPQKRPSAKH 825
++ G PF S ++ + + KH + +A LI+KM+ DP RP+
Sbjct: 243 TLLV-GKPPFETSCLKETYLRIKKNEYSI---PKHINPVAASLIQKMLQTDPTARPTINE 298
Query: 826 VLKHPFFWS 834
+L FF S
Sbjct: 299 LLNDEFFTS 307
>gi|26667191 calcium/calmodulin-dependent protein kinase II gamma
isoform 4 [Homo sapiens]
Length = 495
Score = 90.9 bits (224), Expect = 5e-18
Identities = 68/232 (29%), Positives = 116/232 (50%), Gaps = 29/232 (12%)
Query: 610 DREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAA-------TLQEYVEQKDFAHLG 662
+RE ++ R +HPN++R + + F Y+ +L +EY + D +H
Sbjct: 59 EREARICRLL-KHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHC- 116
Query: 663 LEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGR 722
+ Q + H+H +IVHRDLKP N+L++ +K ++DFGL ++ +
Sbjct: 117 ------IHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVK--LADFGLAIEVQGEQ 168
Query: 723 HSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQ 782
++ G GT G+++PE+L +D P VDI++ G V Y++ G PF Q +
Sbjct: 169 QAW---FGFAGTPGYLSPEVLRKDPYGKP---VDIWACG-VILYILLVGYPPFWDEDQHK 221
Query: 783 ANILLGACSLDCLHPEKHEDVI---ARELIEKMIAMDPQKRPSAKHVLKHPF 831
+ A + D PE D + A+ LI +M+ ++P KR +A LKHP+
Sbjct: 222 LYQQIKAGAYDFPSPE--WDTVTPEAKNLINQMLTINPAKRITADQALKHPW 271
>gi|26667211 calcium/calmodulin-dependent protein kinase II gamma
isoform 6 [Homo sapiens]
Length = 504
Score = 90.9 bits (224), Expect = 5e-18
Identities = 68/232 (29%), Positives = 116/232 (50%), Gaps = 29/232 (12%)
Query: 610 DREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAA-------TLQEYVEQKDFAHLG 662
+RE ++ R +HPN++R + + F Y+ +L +EY + D +H
Sbjct: 59 EREARICRLL-KHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHC- 116
Query: 663 LEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGR 722
+ Q + H+H +IVHRDLKP N+L++ +K ++DFGL ++ +
Sbjct: 117 ------IHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVK--LADFGLAIEVQGEQ 168
Query: 723 HSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQ 782
++ G GT G+++PE+L +D P VDI++ G V Y++ G PF Q +
Sbjct: 169 QAW---FGFAGTPGYLSPEVLRKDPYGKP---VDIWACG-VILYILLVGYPPFWDEDQHK 221
Query: 783 ANILLGACSLDCLHPEKHEDVI---ARELIEKMIAMDPQKRPSAKHVLKHPF 831
+ A + D PE D + A+ LI +M+ ++P KR +A LKHP+
Sbjct: 222 LYQQIKAGAYDFPSPE--WDTVTPEAKNLINQMLTINPAKRITADQALKHPW 271
>gi|26667203 calcium/calmodulin-dependent protein kinase II gamma
isoform 1 [Homo sapiens]
Length = 556
Score = 90.9 bits (224), Expect = 5e-18
Identities = 68/232 (29%), Positives = 116/232 (50%), Gaps = 29/232 (12%)
Query: 610 DREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAA-------TLQEYVEQKDFAHLG 662
+RE ++ R +HPN++R + + F Y+ +L +EY + D +H
Sbjct: 59 EREARICRLL-KHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHC- 116
Query: 663 LEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGR 722
+ Q + H+H +IVHRDLKP N+L++ +K ++DFGL ++ +
Sbjct: 117 ------IHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVK--LADFGLAIEVQGEQ 168
Query: 723 HSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQ 782
++ G GT G+++PE+L +D P VDI++ G V Y++ G PF Q +
Sbjct: 169 QAW---FGFAGTPGYLSPEVLRKDPYGKP---VDIWACG-VILYILLVGYPPFWDEDQHK 221
Query: 783 ANILLGACSLDCLHPEKHEDVI---ARELIEKMIAMDPQKRPSAKHVLKHPF 831
+ A + D PE D + A+ LI +M+ ++P KR +A LKHP+
Sbjct: 222 LYQQIKAGAYDFPSPE--WDTVTPEAKNLINQMLTINPAKRITADQALKHPW 271
>gi|26667196 calcium/calmodulin-dependent protein kinase II gamma
isoform 2 [Homo sapiens]
Length = 527
Score = 90.9 bits (224), Expect = 5e-18
Identities = 68/232 (29%), Positives = 116/232 (50%), Gaps = 29/232 (12%)
Query: 610 DREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAA-------TLQEYVEQKDFAHLG 662
+RE ++ R +HPN++R + + F Y+ +L +EY + D +H
Sbjct: 59 EREARICRLL-KHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHC- 116
Query: 663 LEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGR 722
+ Q + H+H +IVHRDLKP N+L++ +K ++DFGL ++ +
Sbjct: 117 ------IHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVK--LADFGLAIEVQGEQ 168
Query: 723 HSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQ 782
++ G GT G+++PE+L +D P VDI++ G V Y++ G PF Q +
Sbjct: 169 QAW---FGFAGTPGYLSPEVLRKDPYGKP---VDIWACG-VILYILLVGYPPFWDEDQHK 221
Query: 783 ANILLGACSLDCLHPEKHEDVI---ARELIEKMIAMDPQKRPSAKHVLKHPF 831
+ A + D PE D + A+ LI +M+ ++P KR +A LKHP+
Sbjct: 222 LYQQIKAGAYDFPSPE--WDTVTPEAKNLINQMLTINPAKRITADQALKHPW 271
>gi|26051204 calcium/calmodulin-dependent protein kinase II beta
isoform 1 [Homo sapiens]
Length = 666
Score = 90.1 bits (222), Expect = 9e-18
Identities = 66/232 (28%), Positives = 115/232 (49%), Gaps = 29/232 (12%)
Query: 610 DREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAA-------TLQEYVEQKDFAHLG 662
+RE ++ R +H N++R + + F Y+ +L +EY + D +H
Sbjct: 59 EREARICRLL-KHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHC- 116
Query: 663 LEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGR 722
+QQ + H H + +VHRDLKP N+L++ +K ++DFGL ++ +
Sbjct: 117 ------IQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVK--LADFGLAIEVQGDQ 168
Query: 723 HSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQ 782
++ G GT G+++PE+L ++ P VDI++ G V Y++ G PF Q +
Sbjct: 169 QAW---FGFAGTPGYLSPEVLRKEAYGKP---VDIWACG-VILYILLVGYPPFWDEDQHK 221
Query: 783 ANILLGACSLDCLHPEKHEDVI---ARELIEKMIAMDPQKRPSAKHVLKHPF 831
+ A + D PE D + A+ LI +M+ ++P KR +A LKHP+
Sbjct: 222 LYQQIKAGAYDFPSPE--WDTVTPEAKNLINQMLTINPAKRITAHEALKHPW 271
>gi|26051210 calcium/calmodulin-dependent protein kinase II beta
isoform 4 [Homo sapiens]
Length = 517
Score = 90.1 bits (222), Expect = 9e-18
Identities = 66/232 (28%), Positives = 115/232 (49%), Gaps = 29/232 (12%)
Query: 610 DREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAA-------TLQEYVEQKDFAHLG 662
+RE ++ R +H N++R + + F Y+ +L +EY + D +H
Sbjct: 59 EREARICRLL-KHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHC- 116
Query: 663 LEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGR 722
+QQ + H H + +VHRDLKP N+L++ +K ++DFGL ++ +
Sbjct: 117 ------IQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVK--LADFGLAIEVQGDQ 168
Query: 723 HSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQ 782
++ G GT G+++PE+L ++ P VDI++ G V Y++ G PF Q +
Sbjct: 169 QAW---FGFAGTPGYLSPEVLRKEAYGKP---VDIWACG-VILYILLVGYPPFWDEDQHK 221
Query: 783 ANILLGACSLDCLHPEKHEDVI---ARELIEKMIAMDPQKRPSAKHVLKHPF 831
+ A + D PE D + A+ LI +M+ ++P KR +A LKHP+
Sbjct: 222 LYQQIKAGAYDFPSPE--WDTVTPEAKNLINQMLTINPAKRITAHEALKHPW 271
>gi|26051214 calcium/calmodulin-dependent protein kinase II beta
isoform 6 [Homo sapiens]
Length = 492
Score = 90.1 bits (222), Expect = 9e-18
Identities = 66/232 (28%), Positives = 115/232 (49%), Gaps = 29/232 (12%)
Query: 610 DREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAA-------TLQEYVEQKDFAHLG 662
+RE ++ R +H N++R + + F Y+ +L +EY + D +H
Sbjct: 59 EREARICRLL-KHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHC- 116
Query: 663 LEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGR 722
+QQ + H H + +VHRDLKP N+L++ +K ++DFGL ++ +
Sbjct: 117 ------IQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVK--LADFGLAIEVQGDQ 168
Query: 723 HSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQ 782
++ G GT G+++PE+L ++ P VDI++ G V Y++ G PF Q +
Sbjct: 169 QAW---FGFAGTPGYLSPEVLRKEAYGKP---VDIWACG-VILYILLVGYPPFWDEDQHK 221
Query: 783 ANILLGACSLDCLHPEKHEDVI---ARELIEKMIAMDPQKRPSAKHVLKHPF 831
+ A + D PE D + A+ LI +M+ ++P KR +A LKHP+
Sbjct: 222 LYQQIKAGAYDFPSPE--WDTVTPEAKNLINQMLTINPAKRITAHEALKHPW 271
>gi|26051206 calcium/calmodulin-dependent protein kinase II beta
isoform 2 [Homo sapiens]
Length = 542
Score = 90.1 bits (222), Expect = 9e-18
Identities = 66/232 (28%), Positives = 115/232 (49%), Gaps = 29/232 (12%)
Query: 610 DREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAA-------TLQEYVEQKDFAHLG 662
+RE ++ R +H N++R + + F Y+ +L +EY + D +H
Sbjct: 59 EREARICRLL-KHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHC- 116
Query: 663 LEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGR 722
+QQ + H H + +VHRDLKP N+L++ +K ++DFGL ++ +
Sbjct: 117 ------IQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVK--LADFGLAIEVQGDQ 168
Query: 723 HSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQ 782
++ G GT G+++PE+L ++ P VDI++ G V Y++ G PF Q +
Sbjct: 169 QAW---FGFAGTPGYLSPEVLRKEAYGKP---VDIWACG-VILYILLVGYPPFWDEDQHK 221
Query: 783 ANILLGACSLDCLHPEKHEDVI---ARELIEKMIAMDPQKRPSAKHVLKHPF 831
+ A + D PE D + A+ LI +M+ ++P KR +A LKHP+
Sbjct: 222 LYQQIKAGAYDFPSPE--WDTVTPEAKNLINQMLTINPAKRITAHEALKHPW 271
>gi|26051216 calcium/calmodulin-dependent protein kinase II beta
isoform 7 [Homo sapiens]
Length = 479
Score = 90.1 bits (222), Expect = 9e-18
Identities = 66/232 (28%), Positives = 115/232 (49%), Gaps = 29/232 (12%)
Query: 610 DREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAA-------TLQEYVEQKDFAHLG 662
+RE ++ R +H N++R + + F Y+ +L +EY + D +H
Sbjct: 59 EREARICRLL-KHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHC- 116
Query: 663 LEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGR 722
+QQ + H H + +VHRDLKP N+L++ +K ++DFGL ++ +
Sbjct: 117 ------IQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVK--LADFGLAIEVQGDQ 168
Query: 723 HSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQ 782
++ G GT G+++PE+L ++ P VDI++ G V Y++ G PF Q +
Sbjct: 169 QAW---FGFAGTPGYLSPEVLRKEAYGKP---VDIWACG-VILYILLVGYPPFWDEDQHK 221
Query: 783 ANILLGACSLDCLHPEKHEDVI---ARELIEKMIAMDPQKRPSAKHVLKHPF 831
+ A + D PE D + A+ LI +M+ ++P KR +A LKHP+
Sbjct: 222 LYQQIKAGAYDFPSPE--WDTVTPEAKNLINQMLTINPAKRITAHEALKHPW 271
>gi|26051218 calcium/calmodulin-dependent protein kinase II beta
isoform 8 [Homo sapiens]
Length = 449
Score = 90.1 bits (222), Expect = 9e-18
Identities = 66/232 (28%), Positives = 115/232 (49%), Gaps = 29/232 (12%)
Query: 610 DREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAA-------TLQEYVEQKDFAHLG 662
+RE ++ R +H N++R + + F Y+ +L +EY + D +H
Sbjct: 59 EREARICRLL-KHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHC- 116
Query: 663 LEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGR 722
+QQ + H H + +VHRDLKP N+L++ +K ++DFGL ++ +
Sbjct: 117 ------IQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVK--LADFGLAIEVQGDQ 168
Query: 723 HSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQ 782
++ G GT G+++PE+L ++ P VDI++ G V Y++ G PF Q +
Sbjct: 169 QAW---FGFAGTPGYLSPEVLRKEAYGKP---VDIWACG-VILYILLVGYPPFWDEDQHK 221
Query: 783 ANILLGACSLDCLHPEKHEDVI---ARELIEKMIAMDPQKRPSAKHVLKHPF 831
+ A + D PE D + A+ LI +M+ ++P KR +A LKHP+
Sbjct: 222 LYQQIKAGAYDFPSPE--WDTVTPEAKNLINQMLTINPAKRITAHEALKHPW 271
>gi|26051212 calcium/calmodulin-dependent protein kinase II beta
isoform 5 [Homo sapiens]
Length = 503
Score = 90.1 bits (222), Expect = 9e-18
Identities = 66/232 (28%), Positives = 115/232 (49%), Gaps = 29/232 (12%)
Query: 610 DREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAA-------TLQEYVEQKDFAHLG 662
+RE ++ R +H N++R + + F Y+ +L +EY + D +H
Sbjct: 59 EREARICRLL-KHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHC- 116
Query: 663 LEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGR 722
+QQ + H H + +VHRDLKP N+L++ +K ++DFGL ++ +
Sbjct: 117 ------IQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVK--LADFGLAIEVQGDQ 168
Query: 723 HSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQ 782
++ G GT G+++PE+L ++ P VDI++ G V Y++ G PF Q +
Sbjct: 169 QAW---FGFAGTPGYLSPEVLRKEAYGKP---VDIWACG-VILYILLVGYPPFWDEDQHK 221
Query: 783 ANILLGACSLDCLHPEKHEDVI---ARELIEKMIAMDPQKRPSAKHVLKHPF 831
+ A + D PE D + A+ LI +M+ ++P KR +A LKHP+
Sbjct: 222 LYQQIKAGAYDFPSPE--WDTVTPEAKNLINQMLTINPAKRITAHEALKHPW 271
>gi|26051208 calcium/calmodulin-dependent protein kinase II beta
isoform 3 [Homo sapiens]
Length = 518
Score = 90.1 bits (222), Expect = 9e-18
Identities = 66/232 (28%), Positives = 115/232 (49%), Gaps = 29/232 (12%)
Query: 610 DREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAA-------TLQEYVEQKDFAHLG 662
+RE ++ R +H N++R + + F Y+ +L +EY + D +H
Sbjct: 59 EREARICRLL-KHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHC- 116
Query: 663 LEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGR 722
+QQ + H H + +VHRDLKP N+L++ +K ++DFGL ++ +
Sbjct: 117 ------IQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVK--LADFGLAIEVQGDQ 168
Query: 723 HSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQ 782
++ G GT G+++PE+L ++ P VDI++ G V Y++ G PF Q +
Sbjct: 169 QAW---FGFAGTPGYLSPEVLRKEAYGKP---VDIWACG-VILYILLVGYPPFWDEDQHK 221
Query: 783 ANILLGACSLDCLHPEKHEDVI---ARELIEKMIAMDPQKRPSAKHVLKHPF 831
+ A + D PE D + A+ LI +M+ ++P KR +A LKHP+
Sbjct: 222 LYQQIKAGAYDFPSPE--WDTVTPEAKNLINQMLTINPAKRITAHEALKHPW 271
>gi|5453882 phosphorylase kinase gamma subunit 1 [Homo sapiens]
Length = 387
Score = 90.1 bits (222), Expect = 9e-18
Identities = 80/280 (28%), Positives = 134/280 (47%), Gaps = 33/280 (11%)
Query: 573 PKDVLGHGAEGTIVYRGMFD--NRDVAVKRI------------LPECFSFADREVQLLRE 618
PK++LG G ++V R + +++ AVK I + E +EV +LR+
Sbjct: 22 PKEILGRGVS-SVVRRCIHKPTSQEYAVKVIDVTGGGSFSPEEVRELREATLKEVDILRK 80
Query: 619 SDEHPNVIRYFCTEKDRQFQYIAIELCA-ATLQEYVEQKDFAHLGLEPITLLQQTTSGLA 677
HPN+I+ T + F ++ +L L +Y+ +K E +++ +
Sbjct: 81 VSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEK-VTLSEKETRKIMRALLEVIC 139
Query: 678 HLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGW 737
LH LNIVHRDLKP NIL+ + ++DFG +L G R V GT +
Sbjct: 140 TLHKLNIVHRDLKPENILLD-----DNMNIKLTDFGFSCQLEPG----ERLREVCGTPSY 190
Query: 738 IAPEMLSEDCKE-NPTY--TVDIFSAGCVFYYVISEGSHPF--GKSLQRQANILLGACSL 792
+APE++ E +P Y VD++S G + Y +++ GS PF K + I+ G
Sbjct: 191 LAPEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLA-GSPPFWHRKQMLMLRMIMSGNYQF 249
Query: 793 DCLHPEKHEDVIARELIEKMIAMDPQKRPSAKHVLKHPFF 832
+ + D + ++L+ + + + PQ R +A+ L HPFF
Sbjct: 250 GSPEWDDYSDTV-KDLVSRFLVVQPQNRYTAEEALAHPFF 288
>gi|120659787 protein kinase D2 isoform B [Homo sapiens]
Length = 721
Score = 89.4 bits (220), Expect = 2e-17
Identities = 87/301 (28%), Positives = 137/301 (45%), Gaps = 27/301 (8%)
Query: 548 SSPSLEQDDGDEETSVVIVGKISFCPKDVLGHGAEGTIVYRGMF--DNRDVAVKRILPEC 605
+S S+ + + +V I P +VLG G G +VY G RDVAVK I +
Sbjct: 371 ASLSISVSNSQIQENVDIATVYQIFPDEVLGSGQFG-VVYGGKHRKTGRDVAVKVI--DK 427
Query: 606 FSFADREVQLLR------ESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFA 659
F ++ LR +S HP ++ C + + ++ +E + E + +
Sbjct: 428 LRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEMILSSEKG 487
Query: 660 HLGLEPIT--LLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKK 717
L E +T L+ Q L HLH NIVH DLKP N+L++ + ++K + DFG +
Sbjct: 488 RLP-ERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVK--LCDFGFAR- 543
Query: 718 LAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGK 777
+G SF R V GT ++APE+L + ++D++S G + Y +S G+ PF +
Sbjct: 544 -IIGEKSF--RRSVVGTPAYLAPEVL---LNQGYNRSLDMWSVGVIMYVSLS-GTFPFNE 596
Query: 778 SLQRQANILLGACSLDCLHPEKHEDVIARELIEKMIAMDPQKRPSAKHVLKHPFFWSLEK 837
I A + P H A +LI ++ + +KR S L HP W E
Sbjct: 597 DEDINDQI-QNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKSLSHP--WLQEY 653
Query: 838 Q 838
Q
Sbjct: 654 Q 654
>gi|120659785 protein kinase D2 isoform A [Homo sapiens]
Length = 878
Score = 89.4 bits (220), Expect = 2e-17
Identities = 87/301 (28%), Positives = 137/301 (45%), Gaps = 27/301 (8%)
Query: 548 SSPSLEQDDGDEETSVVIVGKISFCPKDVLGHGAEGTIVYRGMF--DNRDVAVKRILPEC 605
+S S+ + + +V I P +VLG G G +VY G RDVAVK I +
Sbjct: 528 ASLSISVSNSQIQENVDIATVYQIFPDEVLGSGQFG-VVYGGKHRKTGRDVAVKVI--DK 584
Query: 606 FSFADREVQLLR------ESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFA 659
F ++ LR +S HP ++ C + + ++ +E + E + +
Sbjct: 585 LRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEMILSSEKG 644
Query: 660 HLGLEPIT--LLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKK 717
L E +T L+ Q L HLH NIVH DLKP N+L++ + ++K + DFG +
Sbjct: 645 RLP-ERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVK--LCDFGFAR- 700
Query: 718 LAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGK 777
+G SF R V GT ++APE+L + ++D++S G + Y +S G+ PF +
Sbjct: 701 -IIGEKSF--RRSVVGTPAYLAPEVL---LNQGYNRSLDMWSVGVIMYVSLS-GTFPFNE 753
Query: 778 SLQRQANILLGACSLDCLHPEKHEDVIARELIEKMIAMDPQKRPSAKHVLKHPFFWSLEK 837
I A + P H A +LI ++ + +KR S L HP W E
Sbjct: 754 DEDINDQI-QNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKSLSHP--WLQEY 810
Query: 838 Q 838
Q
Sbjct: 811 Q 811
>gi|120659782 protein kinase D2 isoform A [Homo sapiens]
Length = 878
Score = 89.4 bits (220), Expect = 2e-17
Identities = 87/301 (28%), Positives = 137/301 (45%), Gaps = 27/301 (8%)
Query: 548 SSPSLEQDDGDEETSVVIVGKISFCPKDVLGHGAEGTIVYRGMF--DNRDVAVKRILPEC 605
+S S+ + + +V I P +VLG G G +VY G RDVAVK I +
Sbjct: 528 ASLSISVSNSQIQENVDIATVYQIFPDEVLGSGQFG-VVYGGKHRKTGRDVAVKVI--DK 584
Query: 606 FSFADREVQLLR------ESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFA 659
F ++ LR +S HP ++ C + + ++ +E + E + +
Sbjct: 585 LRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEMILSSEKG 644
Query: 660 HLGLEPIT--LLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKK 717
L E +T L+ Q L HLH NIVH DLKP N+L++ + ++K + DFG +
Sbjct: 645 RLP-ERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVK--LCDFGFAR- 700
Query: 718 LAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGK 777
+G SF R V GT ++APE+L + ++D++S G + Y +S G+ PF +
Sbjct: 701 -IIGEKSF--RRSVVGTPAYLAPEVL---LNQGYNRSLDMWSVGVIMYVSLS-GTFPFNE 753
Query: 778 SLQRQANILLGACSLDCLHPEKHEDVIARELIEKMIAMDPQKRPSAKHVLKHPFFWSLEK 837
I A + P H A +LI ++ + +KR S L HP W E
Sbjct: 754 DEDINDQI-QNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKSLSHP--WLQEY 810
Query: 838 Q 838
Q
Sbjct: 811 Q 811
>gi|19923468 protein kinase D2 isoform A [Homo sapiens]
Length = 878
Score = 89.4 bits (220), Expect = 2e-17
Identities = 87/301 (28%), Positives = 137/301 (45%), Gaps = 27/301 (8%)
Query: 548 SSPSLEQDDGDEETSVVIVGKISFCPKDVLGHGAEGTIVYRGMF--DNRDVAVKRILPEC 605
+S S+ + + +V I P +VLG G G +VY G RDVAVK I +
Sbjct: 528 ASLSISVSNSQIQENVDIATVYQIFPDEVLGSGQFG-VVYGGKHRKTGRDVAVKVI--DK 584
Query: 606 FSFADREVQLLR------ESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFA 659
F ++ LR +S HP ++ C + + ++ +E + E + +
Sbjct: 585 LRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEMILSSEKG 644
Query: 660 HLGLEPIT--LLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKK 717
L E +T L+ Q L HLH NIVH DLKP N+L++ + ++K + DFG +
Sbjct: 645 RLP-ERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVK--LCDFGFAR- 700
Query: 718 LAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGK 777
+G SF R V GT ++APE+L + ++D++S G + Y +S G+ PF +
Sbjct: 701 -IIGEKSF--RRSVVGTPAYLAPEVL---LNQGYNRSLDMWSVGVIMYVSLS-GTFPFNE 753
Query: 778 SLQRQANILLGACSLDCLHPEKHEDVIARELIEKMIAMDPQKRPSAKHVLKHPFFWSLEK 837
I A + P H A +LI ++ + +KR S L HP W E
Sbjct: 754 DEDINDQI-QNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKSLSHP--WLQEY 810
Query: 838 Q 838
Q
Sbjct: 811 Q 811
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.135 0.403
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,905,887
Number of Sequences: 37866
Number of extensions: 1999229
Number of successful extensions: 10688
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 510
Number of HSP's successfully gapped in prelim test: 386
Number of HSP's that attempted gapping in prelim test: 7997
Number of HSP's gapped (non-prelim): 2146
length of query: 977
length of database: 18,247,518
effective HSP length: 112
effective length of query: 865
effective length of database: 14,006,526
effective search space: 12115644990
effective search space used: 12115644990
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.