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Search of human proteins with 153946403
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|153946403 BCL2/adenovirus E1B 19kD interacting protein 1
isoform BNIP1-a [Homo sapiens]
(194 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|153946403 BCL2/adenovirus E1B 19kD interacting protein 1 isof... 368 e-102
gi|153946401 BCL2/adenovirus E1B 19kD interacting protein 1 isof... 351 3e-97
gi|153946405 BCL2/adenovirus E1B 19kD interacting protein 1 isof... 347 3e-96
gi|153946399 BCL2/adenovirus E1B 19kD interacting protein 1 isof... 330 5e-91
gi|119120918 coiled-coil domain containing 64 [Homo sapiens] 43 1e-04
gi|28195388 RAB11 family interacting protein 4 (class II) [Homo ... 43 2e-04
gi|71061468 centromere protein E [Homo sapiens] 42 4e-04
gi|205277396 dynactin 1 isoform 4 [Homo sapiens] 40 0.002
gi|205277392 dynactin 1 isoform 3 [Homo sapiens] 40 0.002
gi|13259508 dynactin 1 isoform 2 [Homo sapiens] 40 0.002
gi|13259510 dynactin 1 isoform 1 [Homo sapiens] 40 0.002
gi|38044112 restin isoform b [Homo sapiens] 40 0.002
gi|4506751 restin isoform a [Homo sapiens] 40 0.002
gi|109715852 chromosome 6 open reading frame 204 isoform a [Homo... 40 0.002
gi|226958575 RAS protein activator like 2 isoform 2 [Homo sapiens] 39 0.002
gi|4758808 RAS protein activator like 2 isoform 1 [Homo sapiens] 39 0.002
gi|238908495 similar to pleckstrin homology domain protein (5V32... 39 0.002
gi|239756284 PREDICTED: similar to GOLGA8B protein, partial [Hom... 39 0.002
gi|70166430 GRINL1A combined protein isoform 2 [Homo sapiens] 39 0.002
gi|70166414 GRINL1A combined protein isoform 1 [Homo sapiens] 39 0.002
gi|111494235 GRINL1A combined protein isoform 8 [Homo sapiens] 39 0.002
gi|70166580 GRINL1A upstream protein isoform 7 [Homo sapiens] 39 0.002
gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens] 39 0.003
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 39 0.004
gi|116256445 nuclear receptor co-repressor 2 isoform 2 [Homo sap... 38 0.005
gi|116256453 nuclear receptor co-repressor 2 isoform 1 [Homo sap... 38 0.005
gi|148613880 hypothetical protein LOC145773 [Homo sapiens] 38 0.005
gi|109255234 centrosomal protein 290kDa [Homo sapiens] 37 0.008
gi|56550047 uveal autoantigen with coiled-coil domains and ankyr... 37 0.008
gi|59850762 uveal autoantigen with coiled-coil domains and ankyr... 37 0.008
>gi|153946403 BCL2/adenovirus E1B 19kD interacting protein 1 isoform
BNIP1-a [Homo sapiens]
Length = 194
Score = 368 bits (945), Expect = e-102
Identities = 194/194 (100%), Positives = 194/194 (100%)
Query: 1 MAAPQDVHVRICNQEIVKFDLEVKALIQDIRDCSGPLSALTELNTKVKEKFQQLRHRIQD 60
MAAPQDVHVRICNQEIVKFDLEVKALIQDIRDCSGPLSALTELNTKVKEKFQQLRHRIQD
Sbjct: 1 MAAPQDVHVRICNQEIVKFDLEVKALIQDIRDCSGPLSALTELNTKVKEKFQQLRHRIQD 60
Query: 61 LEQLAKEQDKESEKQLLLQEVENHKKQMLRKTTKESLAQTSSTITESLMGISRMMAQQVQ 120
LEQLAKEQDKESEKQLLLQEVENHKKQMLRKTTKESLAQTSSTITESLMGISRMMAQQVQ
Sbjct: 61 LEQLAKEQDKESEKQLLLQEVENHKKQMLRKTTKESLAQTSSTITESLMGISRMMAQQVQ 120
Query: 121 QSEEAMQSLVTSSRTILDANEEFKSMSGTIQLGRKLITKYNRRELTDKLLIFLALALFLA 180
QSEEAMQSLVTSSRTILDANEEFKSMSGTIQLGRKLITKYNRRELTDKLLIFLALALFLA
Sbjct: 121 QSEEAMQSLVTSSRTILDANEEFKSMSGTIQLGRKLITKYNRRELTDKLLIFLALALFLA 180
Query: 181 TVLYIVKKRLFPFL 194
TVLYIVKKRLFPFL
Sbjct: 181 TVLYIVKKRLFPFL 194
>gi|153946401 BCL2/adenovirus E1B 19kD interacting protein 1 isoform
BNIP1 [Homo sapiens]
Length = 228
Score = 351 bits (900), Expect = 3e-97
Identities = 194/228 (85%), Positives = 194/228 (85%), Gaps = 34/228 (14%)
Query: 1 MAAPQDVHVRICNQEIVKFDLEVKALIQDIRDCSGPLSALTELNTKVKEKFQQLRHRIQD 60
MAAPQDVHVRICNQEIVKFDLEVKALIQDIRDCSGPLSALTELNTKVKEKFQQLRHRIQD
Sbjct: 1 MAAPQDVHVRICNQEIVKFDLEVKALIQDIRDCSGPLSALTELNTKVKEKFQQLRHRIQD 60
Query: 61 LEQLAKEQDKESEKQLLLQEVENHKKQML------------------------------- 89
LEQLAKEQDKESEKQLLLQEVENHKKQML
Sbjct: 61 LEQLAKEQDKESEKQLLLQEVENHKKQMLSNQASWRKANLTCKIAIDNLEKAELLQGGDL 120
Query: 90 ---RKTTKESLAQTSSTITESLMGISRMMAQQVQQSEEAMQSLVTSSRTILDANEEFKSM 146
RKTTKESLAQTSSTITESLMGISRMMAQQVQQSEEAMQSLVTSSRTILDANEEFKSM
Sbjct: 121 LRQRKTTKESLAQTSSTITESLMGISRMMAQQVQQSEEAMQSLVTSSRTILDANEEFKSM 180
Query: 147 SGTIQLGRKLITKYNRRELTDKLLIFLALALFLATVLYIVKKRLFPFL 194
SGTIQLGRKLITKYNRRELTDKLLIFLALALFLATVLYIVKKRLFPFL
Sbjct: 181 SGTIQLGRKLITKYNRRELTDKLLIFLALALFLATVLYIVKKRLFPFL 228
>gi|153946405 BCL2/adenovirus E1B 19kD interacting protein 1 isoform
BNIP1-c [Homo sapiens]
Length = 237
Score = 347 bits (891), Expect = 3e-96
Identities = 194/237 (81%), Positives = 194/237 (81%), Gaps = 43/237 (18%)
Query: 1 MAAPQDVHVRICNQEIVKFDLEVKALIQDIRDCSGPLSALTELNTKVKEKFQQLRHRIQ- 59
MAAPQDVHVRICNQEIVKFDLEVKALIQDIRDCSGPLSALTELNTKVKEKFQQLRHRIQ
Sbjct: 1 MAAPQDVHVRICNQEIVKFDLEVKALIQDIRDCSGPLSALTELNTKVKEKFQQLRHRIQP 60
Query: 60 ------------------------------------------DLEQLAKEQDKESEKQLL 77
DLEQLAKEQDKESEKQLL
Sbjct: 61 VLYQRAFIWTASTFFFKLTYSLTDFSSTQHDFNSPTTPVTFSDLEQLAKEQDKESEKQLL 120
Query: 78 LQEVENHKKQMLRKTTKESLAQTSSTITESLMGISRMMAQQVQQSEEAMQSLVTSSRTIL 137
LQEVENHKKQMLRKTTKESLAQTSSTITESLMGISRMMAQQVQQSEEAMQSLVTSSRTIL
Sbjct: 121 LQEVENHKKQMLRKTTKESLAQTSSTITESLMGISRMMAQQVQQSEEAMQSLVTSSRTIL 180
Query: 138 DANEEFKSMSGTIQLGRKLITKYNRRELTDKLLIFLALALFLATVLYIVKKRLFPFL 194
DANEEFKSMSGTIQLGRKLITKYNRRELTDKLLIFLALALFLATVLYIVKKRLFPFL
Sbjct: 181 DANEEFKSMSGTIQLGRKLITKYNRRELTDKLLIFLALALFLATVLYIVKKRLFPFL 237
>gi|153946399 BCL2/adenovirus E1B 19kD interacting protein 1 isoform
BNIP1-b [Homo sapiens]
Length = 271
Score = 330 bits (846), Expect = 5e-91
Identities = 194/271 (71%), Positives = 194/271 (71%), Gaps = 77/271 (28%)
Query: 1 MAAPQDVHVRICNQEIVKFDLEVKALIQDIRDCSGPLSALTELNTKVKEKFQQLRHRIQ- 59
MAAPQDVHVRICNQEIVKFDLEVKALIQDIRDCSGPLSALTELNTKVKEKFQQLRHRIQ
Sbjct: 1 MAAPQDVHVRICNQEIVKFDLEVKALIQDIRDCSGPLSALTELNTKVKEKFQQLRHRIQP 60
Query: 60 ------------------------------------------DLEQLAKEQDKESEKQLL 77
DLEQLAKEQDKESEKQLL
Sbjct: 61 VLYQRAFIWTASTFFFKLTYSLTDFSSTQHDFNSPTTPVTFSDLEQLAKEQDKESEKQLL 120
Query: 78 LQEVENHKKQML----------------------------------RKTTKESLAQTSST 103
LQEVENHKKQML RKTTKESLAQTSST
Sbjct: 121 LQEVENHKKQMLSNQASWRKANLTCKIAIDNLEKAELLQGGDLLRQRKTTKESLAQTSST 180
Query: 104 ITESLMGISRMMAQQVQQSEEAMQSLVTSSRTILDANEEFKSMSGTIQLGRKLITKYNRR 163
ITESLMGISRMMAQQVQQSEEAMQSLVTSSRTILDANEEFKSMSGTIQLGRKLITKYNRR
Sbjct: 181 ITESLMGISRMMAQQVQQSEEAMQSLVTSSRTILDANEEFKSMSGTIQLGRKLITKYNRR 240
Query: 164 ELTDKLLIFLALALFLATVLYIVKKRLFPFL 194
ELTDKLLIFLALALFLATVLYIVKKRLFPFL
Sbjct: 241 ELTDKLLIFLALALFLATVLYIVKKRLFPFL 271
>gi|119120918 coiled-coil domain containing 64 [Homo sapiens]
Length = 573
Score = 43.1 bits (100), Expect = 1e-04
Identities = 36/124 (29%), Positives = 65/124 (52%), Gaps = 9/124 (7%)
Query: 13 NQEIVKFD---LEVKALIQDIRDCSGPLSALTELNTKVKEKFQQLRHRIQDLEQLAKEQD 69
NQ I++ + E+K L R+ LSA E N ++ ++L+ R+ LE+ ++D
Sbjct: 242 NQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQGTVEELQDRVLILERQGHDKD 301
Query: 70 KE-SEKQLLLQEVENHKKQMLRK----TTKESLAQTSSTITESLMGISRMM-AQQVQQSE 123
+ + QL LQEV +Q+ K T + SL +++T T L I + M A++++Q
Sbjct: 302 LQLHQSQLELQEVRLSCRQLQVKVEELTEERSLQSSAATSTSLLSEIEQSMEAEELEQER 361
Query: 124 EAMQ 127
E ++
Sbjct: 362 EQLR 365
>gi|28195388 RAB11 family interacting protein 4 (class II) [Homo
sapiens]
Length = 637
Score = 42.7 bits (99), Expect = 2e-04
Identities = 38/141 (26%), Positives = 67/141 (47%), Gaps = 15/141 (10%)
Query: 42 ELNTKVKEKFQQLRHRIQDLEQLAKEQDKESEKQLLLQEVENHK----KQMLRKTTKESL 97
+L +K+K++ QL HR+ +LE++ K+Q+ +E Q L +E H+ K K T+ L
Sbjct: 363 DLKSKLKQENTQLVHRVHELEEMVKDQETTAE-QALEEEARRHREAYGKLEREKATEVEL 421
Query: 98 -----AQTSSTITESLMGISRMMAQQVQQSEEAMQ---SLVTSSRTILDANEEFKSMSGT 149
Q TE ++R+ +Q + EE + L +S + D + +K M
Sbjct: 422 LNARVQQLEEENTELRTTVTRLKSQTEKLDEERQRMSDRLEDTSLRLKDEMDLYKRMMDK 481
Query: 150 IQLGRKLITKYNRRELTDKLL 170
++ R K RE T +L+
Sbjct: 482 LRQNRLEFQK--EREATQELI 500
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 41.6 bits (96), Expect = 4e-04
Identities = 36/133 (27%), Positives = 64/133 (48%), Gaps = 17/133 (12%)
Query: 14 QEIVKFDLEVKALIQDIRDCSGPLSALTELNTKVKEKFQQLRHRIQDLEQLAKEQDKESE 73
QEIV E I+ + S L E+ K+KEK QQL+ + Q QL Q++ SE
Sbjct: 1098 QEIVA--QEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQ---QLLNVQEEMSE 1152
Query: 74 KQLLLQEVENHKKQMLRKTTKESLAQTSSTITESLMGISRM-MAQQVQQSEEAMQSLVTS 132
Q + E+EN K ++ K +T M R+ +AQ++ ++ E ++S+
Sbjct: 1153 MQKKINEIENLKNELKNK-----------ELTLEHMETERLELAQKLNENYEEVKSITKE 1201
Query: 133 SRTILDANEEFKS 145
+ + + + F++
Sbjct: 1202 RKVLKELQKSFET 1214
Score = 33.9 bits (76), Expect = 0.089
Identities = 33/167 (19%), Positives = 73/167 (43%), Gaps = 14/167 (8%)
Query: 13 NQEIVKFDLEVKALIQDIRDCSGPLSALTELNTKVKEKFQQLRHRIQDLEQLAKE----- 67
NQEIV E + + LS T+ +++EK ++++ R+ ++EQL ++
Sbjct: 844 NQEIVNLSKEAQKFDSSLGALKTELSYKTQ---ELQEKTREVQERLNEMEQLKEQLENRD 900
Query: 68 ---QDKESEKQLLLQEVENHKKQMLRKT-TKESLAQTSSTITESLMGISRMMAQQVQQSE 123
Q E EK L+ ++++ +++ T K+ L Q ++ + + V +
Sbjct: 901 STLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNI 960
Query: 124 EAMQSLVTSSRTILDANEEFKSMSGTI--QLGRKLITKYNRRELTDK 168
+ + L + ++ E ++ I ++ R L + N E D+
Sbjct: 961 DTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDE 1007
Score = 32.0 bits (71), Expect = 0.34
Identities = 27/129 (20%), Positives = 56/129 (43%), Gaps = 3/129 (2%)
Query: 15 EIVKFDLEVKALIQDIRDCSGPLSALTELNTKVKEKFQQLRHRIQDLEQLAKEQDKESEK 74
E+V + V+ L+++I L+ ++FQ + D EQ K +E+E+
Sbjct: 783 EVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENER 842
Query: 75 QLLLQEVENHKKQMLRKTTKESLAQTS-STITESLMGISRMMAQQVQQSEEAMQSLVTSS 133
+ QE+ N K+ + + +T S T+ L +R + +++ + E+ + L
Sbjct: 843 --MNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRD 900
Query: 134 RTILDANEE 142
T+ E
Sbjct: 901 STLQTVERE 909
Score = 32.0 bits (71), Expect = 0.34
Identities = 18/100 (18%), Positives = 45/100 (45%)
Query: 22 EVKALIQDIRDCSGPLSALTELNTKVKEKFQQLRHRIQDLEQLAKEQDKESEKQLLLQEV 81
EV+ + +++ A ++ K +L +R+Q+ ++ + KE E+ +QE
Sbjct: 1542 EVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEA 1601
Query: 82 ENHKKQMLRKTTKESLAQTSSTITESLMGISRMMAQQVQQ 121
++ L++ TKE +A+ + + + + Q+
Sbjct: 1602 LQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQE 1641
Score = 30.8 bits (68), Expect = 0.76
Identities = 26/106 (24%), Positives = 50/106 (47%), Gaps = 15/106 (14%)
Query: 40 LTELNTKVKEKFQQLRHRIQDLEQLAKEQDKESEKQLLLQEVENHKKQMLRKTTKESLAQ 99
L N K++EK Q+L+ L L K+ ++ +K + E+E KKQ+
Sbjct: 1811 LENSNAKLQEKIQELKANEHQLITLKKDVNETQKK---VSEMEQLKKQI----------- 1856
Query: 100 TSSTITESLMGISRM-MAQQVQQSEEAMQSLVTSSRTILDANEEFK 144
++T S + I + +AQ++ ++ E M+S++ + E K
Sbjct: 1857 KDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLK 1902
Score = 28.9 bits (63), Expect = 2.9
Identities = 29/145 (20%), Positives = 62/145 (42%), Gaps = 7/145 (4%)
Query: 20 DLEVKALIQDIRDCSGPLSALTELNTKVKEKFQQLRHRIQDLEQLAKEQDKESEKQLLLQ 79
D E ++ ++ SAL + ++ ++L+ +++ +AKE+D LQ
Sbjct: 1396 DNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQR----LQ 1451
Query: 80 EVENHKKQMLRKTTKESLAQTSSTITESLMGISRMMAQQVQQSEEAMQSLVTSSRTILDA 139
EV + L++ KE +A+ T E L + +Q + E +L I
Sbjct: 1452 EVLQSESDQLKENIKEIVAKHLET-EEELKVAHCCLKEQEETINELRVNLSEKETEISTI 1510
Query: 140 NEEFKSMSGTIQLGRKLITKYNRRE 164
++ ++++ +Q K+ Y + E
Sbjct: 1511 QKQLEAINDKLQ--NKIQEIYEKEE 1533
Score = 28.1 bits (61), Expect = 4.9
Identities = 31/157 (19%), Positives = 66/157 (42%), Gaps = 20/157 (12%)
Query: 15 EIVKFDLEVKALIQDIRDCSGPLSALTELNTKVKEKFQQLRHRIQD-LEQLAKEQD---- 69
E+ EV+ L ++I+D S L +T K+ + R+Q LE++ K +D
Sbjct: 748 ELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLAT 807
Query: 70 KESEKQLLLQEVENHK----------KQMLRKTTK-----ESLAQTSSTITESLMGISRM 114
+S + QE +N K K +L + + +L++ + SL +
Sbjct: 808 TQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTE 867
Query: 115 MAQQVQQSEEAMQSLVTSSRTILDANEEFKSMSGTIQ 151
++ + Q+ +E + + + E+ ++ T+Q
Sbjct: 868 LSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQ 904
Score = 28.1 bits (61), Expect = 4.9
Identities = 31/150 (20%), Positives = 65/150 (43%), Gaps = 21/150 (14%)
Query: 13 NQEIVKFDLEVKALIQDIRDCSGPLSALTELNTKVKEKFQQLRHRIQD----LEQLAKEQ 68
N++ + E+K+L ++ + AL + ++KE ++ +IQ+ EQ +
Sbjct: 1334 NEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMK 1393
Query: 69 DKESEKQLLLQEVENHKKQ------------MLRKTTKESLAQTSSTITE--SLMGISRM 114
+K++E ++ E+E K + L K +ES + S E L + +
Sbjct: 1394 EKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEV 1453
Query: 115 MAQQVQQSEEAMQSLVTSSRTILDANEEFK 144
+ + Q +E ++ +V L+ EE K
Sbjct: 1454 LQSESDQLKENIKEIVAKH---LETEEELK 1480
>gi|205277396 dynactin 1 isoform 4 [Homo sapiens]
Length = 1139
Score = 39.7 bits (91), Expect = 0.002
Identities = 39/139 (28%), Positives = 68/139 (48%), Gaps = 13/139 (9%)
Query: 22 EVKALIQDIRDCSGPLSALTELNTKVKEKFQQL-RHRIQDLEQL----AKEQDKESEKQL 76
E + L +RD L L + K K ++L +H+IQ LEQ+ +K Q+++++ Q
Sbjct: 82 EEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQ-LEQVQEWKSKMQEQQADLQR 140
Query: 77 LLQEVENHKKQML--RKTTKESLAQTSSTITESLMG--ISRMMAQQVQQSEEAMQSLV-- 130
L+E K+ L ++ E +A T+ I + + ++ A+ +QQ EA++ V
Sbjct: 141 RLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDE 200
Query: 131 -TSSRTILDANEEFKSMSG 148
T+ IL A E K G
Sbjct: 201 LTTDLEILKAEIEEKGSDG 219
Score = 35.4 bits (80), Expect = 0.031
Identities = 29/122 (23%), Positives = 52/122 (42%), Gaps = 16/122 (13%)
Query: 22 EVKALIQDIRDCSGPLSALTELNTKVKEKFQQLRHRIQDLEQL----------AKEQDKE 71
E+K + + LT+ N ++EK ++LR + DLE + A+E + E
Sbjct: 291 ELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELE 350
Query: 72 SEKQLLLQEVENHKKQMLRKTTKESLAQTSSTI------TESLMGISRMMAQQVQQSEEA 125
+QL + + Q + +E++A TI T L ++R + Q + S E
Sbjct: 351 LREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVER 410
Query: 126 MQ 127
Q
Sbjct: 411 QQ 412
>gi|205277392 dynactin 1 isoform 3 [Homo sapiens]
Length = 1253
Score = 39.7 bits (91), Expect = 0.002
Identities = 39/139 (28%), Positives = 68/139 (48%), Gaps = 13/139 (9%)
Query: 22 EVKALIQDIRDCSGPLSALTELNTKVKEKFQQL-RHRIQDLEQL----AKEQDKESEKQL 76
E + L +RD L L + K K ++L +H+IQ LEQ+ +K Q+++++ Q
Sbjct: 196 EEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQ-LEQVQEWKSKMQEQQADLQR 254
Query: 77 LLQEVENHKKQML--RKTTKESLAQTSSTITESLMG--ISRMMAQQVQQSEEAMQSLV-- 130
L+E K+ L ++ E +A T+ I + + ++ A+ +QQ EA++ V
Sbjct: 255 RLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDE 314
Query: 131 -TSSRTILDANEEFKSMSG 148
T+ IL A E K G
Sbjct: 315 LTTDLEILKAEIEEKGSDG 333
Score = 35.4 bits (80), Expect = 0.031
Identities = 29/122 (23%), Positives = 52/122 (42%), Gaps = 16/122 (13%)
Query: 22 EVKALIQDIRDCSGPLSALTELNTKVKEKFQQLRHRIQDLEQL----------AKEQDKE 71
E+K + + LT+ N ++EK ++LR + DLE + A+E + E
Sbjct: 405 ELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELE 464
Query: 72 SEKQLLLQEVENHKKQMLRKTTKESLAQTSSTI------TESLMGISRMMAQQVQQSEEA 125
+QL + + Q + +E++A TI T L ++R + Q + S E
Sbjct: 465 LREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVER 524
Query: 126 MQ 127
Q
Sbjct: 525 QQ 526
>gi|13259508 dynactin 1 isoform 2 [Homo sapiens]
Length = 1144
Score = 39.7 bits (91), Expect = 0.002
Identities = 39/139 (28%), Positives = 68/139 (48%), Gaps = 13/139 (9%)
Query: 22 EVKALIQDIRDCSGPLSALTELNTKVKEKFQQL-RHRIQDLEQL----AKEQDKESEKQL 76
E + L +RD L L + K K ++L +H+IQ LEQ+ +K Q+++++ Q
Sbjct: 82 EEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQ-LEQVQEWKSKMQEQQADLQR 140
Query: 77 LLQEVENHKKQML--RKTTKESLAQTSSTITESLMG--ISRMMAQQVQQSEEAMQSLV-- 130
L+E K+ L ++ E +A T+ I + + ++ A+ +QQ EA++ V
Sbjct: 141 RLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDE 200
Query: 131 -TSSRTILDANEEFKSMSG 148
T+ IL A E K G
Sbjct: 201 LTTDLEILKAEIEEKGSDG 219
Score = 35.4 bits (80), Expect = 0.031
Identities = 29/122 (23%), Positives = 52/122 (42%), Gaps = 16/122 (13%)
Query: 22 EVKALIQDIRDCSGPLSALTELNTKVKEKFQQLRHRIQDLEQL----------AKEQDKE 71
E+K + + LT+ N ++EK ++LR + DLE + A+E + E
Sbjct: 291 ELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELE 350
Query: 72 SEKQLLLQEVENHKKQMLRKTTKESLAQTSSTI------TESLMGISRMMAQQVQQSEEA 125
+QL + + Q + +E++A TI T L ++R + Q + S E
Sbjct: 351 LREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVER 410
Query: 126 MQ 127
Q
Sbjct: 411 QQ 412
>gi|13259510 dynactin 1 isoform 1 [Homo sapiens]
Length = 1278
Score = 39.7 bits (91), Expect = 0.002
Identities = 39/139 (28%), Positives = 68/139 (48%), Gaps = 13/139 (9%)
Query: 22 EVKALIQDIRDCSGPLSALTELNTKVKEKFQQL-RHRIQDLEQL----AKEQDKESEKQL 76
E + L +RD L L + K K ++L +H+IQ LEQ+ +K Q+++++ Q
Sbjct: 216 EEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQ-LEQVQEWKSKMQEQQADLQR 274
Query: 77 LLQEVENHKKQML--RKTTKESLAQTSSTITESLMG--ISRMMAQQVQQSEEAMQSLV-- 130
L+E K+ L ++ E +A T+ I + + ++ A+ +QQ EA++ V
Sbjct: 275 RLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDE 334
Query: 131 -TSSRTILDANEEFKSMSG 148
T+ IL A E K G
Sbjct: 335 LTTDLEILKAEIEEKGSDG 353
Score = 35.4 bits (80), Expect = 0.031
Identities = 29/122 (23%), Positives = 52/122 (42%), Gaps = 16/122 (13%)
Query: 22 EVKALIQDIRDCSGPLSALTELNTKVKEKFQQLRHRIQDLEQL----------AKEQDKE 71
E+K + + LT+ N ++EK ++LR + DLE + A+E + E
Sbjct: 425 ELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELE 484
Query: 72 SEKQLLLQEVENHKKQMLRKTTKESLAQTSSTI------TESLMGISRMMAQQVQQSEEA 125
+QL + + Q + +E++A TI T L ++R + Q + S E
Sbjct: 485 LREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVER 544
Query: 126 MQ 127
Q
Sbjct: 545 QQ 546
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 39.7 bits (91), Expect = 0.002
Identities = 35/158 (22%), Positives = 78/158 (49%), Gaps = 7/158 (4%)
Query: 13 NQEIVKFDLEVKALIQDIRDCSGPLSALTELNTKVKEKFQQLRHRIQDLEQLAKEQDKES 72
NQ++ +F E++ L Q S LSAL E N K+ E+ + R + ++L +E+ +
Sbjct: 1102 NQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLN 1161
Query: 73 EKQLLLQEVENHKKQMLRKTTKESLA-QTSSTITESLMGISRMMAQQVQQSEEAMQSLVT 131
+ L E++ + + ++ +E + Q S +IT +L+ ++++ ++
Sbjct: 1162 NQ---LLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENA 1218
Query: 132 SSRTILDANEEFKSMSGTIQLGRK---LITKYNRRELT 166
S++++ + +S ++L K L K N+R+L+
Sbjct: 1219 SAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLS 1256
Score = 29.3 bits (64), Expect = 2.2
Identities = 21/112 (18%), Positives = 53/112 (47%), Gaps = 6/112 (5%)
Query: 40 LTELNTKVKEKFQQLRHRIQDLEQLAKEQDKESEKQLLLQEVENHKKQMLRKTTK----- 94
L + K+K ++ +Q+LE+L K+ DK Q ++ +QM ++ T+
Sbjct: 1005 LLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQ-TAEDAMQIMEQMTKEKTETLASL 1063
Query: 95 ESLAQTSSTITESLMGISRMMAQQVQQSEEAMQSLVTSSRTILDANEEFKSM 146
E QT++ + L + + V++ ++ + L ++ + + +E +++
Sbjct: 1064 EDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETL 1115
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 39.7 bits (91), Expect = 0.002
Identities = 35/158 (22%), Positives = 78/158 (49%), Gaps = 7/158 (4%)
Query: 13 NQEIVKFDLEVKALIQDIRDCSGPLSALTELNTKVKEKFQQLRHRIQDLEQLAKEQDKES 72
NQ++ +F E++ L Q S LSAL E N K+ E+ + R + ++L +E+ +
Sbjct: 1137 NQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLN 1196
Query: 73 EKQLLLQEVENHKKQMLRKTTKESLA-QTSSTITESLMGISRMMAQQVQQSEEAMQSLVT 131
+ L E++ + + ++ +E + Q S +IT +L+ ++++ ++
Sbjct: 1197 NQ---LLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENA 1253
Query: 132 SSRTILDANEEFKSMSGTIQLGRK---LITKYNRRELT 166
S++++ + +S ++L K L K N+R+L+
Sbjct: 1254 SAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLS 1291
Score = 29.3 bits (64), Expect = 2.2
Identities = 21/112 (18%), Positives = 53/112 (47%), Gaps = 6/112 (5%)
Query: 40 LTELNTKVKEKFQQLRHRIQDLEQLAKEQDKESEKQLLLQEVENHKKQMLRKTTK----- 94
L + K+K ++ +Q+LE+L K+ DK Q ++ +QM ++ T+
Sbjct: 1040 LLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQ-TAEDAMQIMEQMTKEKTETLASL 1098
Query: 95 ESLAQTSSTITESLMGISRMMAQQVQQSEEAMQSLVTSSRTILDANEEFKSM 146
E QT++ + L + + V++ ++ + L ++ + + +E +++
Sbjct: 1099 EDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETL 1150
>gi|109715852 chromosome 6 open reading frame 204 isoform a [Homo
sapiens]
Length = 805
Score = 39.7 bits (91), Expect = 0.002
Identities = 36/150 (24%), Positives = 69/150 (46%), Gaps = 17/150 (11%)
Query: 27 IQDIRDCSGPLSALTELNTKVKEKFQQLRHRIQDLEQLAKEQDKESEKQLLLQEVENHKK 86
+ D++ S L L E N ++E +++++ K+Q ++ E QL+ Q+ KK
Sbjct: 521 LDDVQSQSLQLQILEEKNKNLQEALIDTEKKLEEI----KKQCQDKETQLICQK----KK 572
Query: 87 QMLRKTTKESLAQTSSTITESLMGISRMMAQQVQQSEEAMQSLVTSSRTILDANE----- 141
+ TT +SL Q E + + + A+Q+Q + ++ ++ I+D+ +
Sbjct: 573 EKELVTTVQSLQQKVERCLEDGIRLPMLDAKQLQNENDNLRQQNETASKIIDSQQDEIDR 632
Query: 142 ---EFKSMSGTIQLGRKLITKYNRRELTDK 168
E +SM G + KL T+ EL K
Sbjct: 633 MILEIQSMQGKLS-KEKLTTQKMMEELEKK 661
>gi|226958575 RAS protein activator like 2 isoform 2 [Homo sapiens]
Length = 1280
Score = 39.3 bits (90), Expect = 0.002
Identities = 26/101 (25%), Positives = 56/101 (55%), Gaps = 10/101 (9%)
Query: 45 TKVKEKFQQLRHRIQDLEQLAKEQDKESEKQLLLQEVE-NHKKQMLRKTTKESLAQTSST 103
TK+KE+ + R+++ E+ Q+++ +K LL + ++ LR+ +E +Q S
Sbjct: 1135 TKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLEDSEERLRRQQEEKDSQMKSI 1194
Query: 104 ITESLMGISRMMA--QQVQQSEEAMQSLVTSSRTILDANEE 142
ISR+MA +++++ MQ+++ + + I+DA E+
Sbjct: 1195 -------ISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEK 1228
>gi|4758808 RAS protein activator like 2 isoform 1 [Homo sapiens]
Length = 1139
Score = 39.3 bits (90), Expect = 0.002
Identities = 26/101 (25%), Positives = 56/101 (55%), Gaps = 10/101 (9%)
Query: 45 TKVKEKFQQLRHRIQDLEQLAKEQDKESEKQLLLQEVE-NHKKQMLRKTTKESLAQTSST 103
TK+KE+ + R+++ E+ Q+++ +K LL + ++ LR+ +E +Q S
Sbjct: 994 TKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLEDSEERLRRQQEEKDSQMKSI 1053
Query: 104 ITESLMGISRMMA--QQVQQSEEAMQSLVTSSRTILDANEE 142
ISR+MA +++++ MQ+++ + + I+DA E+
Sbjct: 1054 -------ISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEK 1087
>gi|238908495 similar to pleckstrin homology domain protein (5V327)
[Homo sapiens]
Length = 506
Score = 39.3 bits (90), Expect = 0.002
Identities = 34/147 (23%), Positives = 71/147 (48%), Gaps = 11/147 (7%)
Query: 13 NQEIVKFDLEVKALIQDIRDCSGPLSALTELNTK----VKEKFQQLRHRIQDLEQLAKEQ 68
NQ + + + ++Q++R + EL + V+++ ++LRH + L+Q +E
Sbjct: 191 NQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQEKKELRHLTESLQQTLEEL 250
Query: 69 DKESEKQL-LLQEVENHKKQMLRKTTKESLAQTSSTITESLMGISRMMAQQVQQ---SEE 124
E +K L +L+E ENH + + ++ + S + +L I M Q +++ +E+
Sbjct: 251 SIEKKKTLEMLEENENHLQTLANQSEQ---PPPSGGLHSNLRQIEEKMQQLLEEKLLAEK 307
Query: 125 AMQSLVTSSRTILDANEEFKSMSGTIQ 151
M+ SR + + E + S S +Q
Sbjct: 308 RMKENEERSRALEEEREFYSSQSQALQ 334
Score = 27.7 bits (60), Expect = 6.4
Identities = 22/105 (20%), Positives = 47/105 (44%), Gaps = 11/105 (10%)
Query: 48 KEKFQQLRHRIQDLEQLAKEQDKESEKQLLLQEVENHKKQMLR-----KTTKESLAQTSS 102
KEK + L +++ E+L ++++ E + L Q +E K+Q + +E + +
Sbjct: 161 KEKQEYLDKLMEETEELCLQREQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELE 220
Query: 103 TITESLMGIS------RMMAQQVQQSEEAMQSLVTSSRTILDANE 141
L G+ R + + +QQ+ E + + +L+ NE
Sbjct: 221 LTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENE 265
>gi|239756284 PREDICTED: similar to GOLGA8B protein, partial [Homo
sapiens]
Length = 314
Score = 39.3 bits (90), Expect = 0.002
Identities = 28/107 (26%), Positives = 55/107 (51%), Gaps = 16/107 (14%)
Query: 17 VKFDLEVKALIQDIRDCSGPLSALTE-------LNTKVKEKFQQLRHRIQDLEQLAKEQD 69
V ++E++ L +++ +G L A E LN KE+ ++ R+Q+ ++ +EQ+
Sbjct: 6 VSSEVELQDLRKELERVAGELQAQVENNQCISLLNRGQKERLREQEERLQEQQERLREQE 65
Query: 70 KE----SEKQLLLQEVENHKKQMLR-----KTTKESLAQTSSTITES 107
K +E Q L+E+++ K L+ K +E L Q + T+T +
Sbjct: 66 KRLQQLAEPQSDLEELKHENKSALQLEQQVKELQEKLGQVTETLTSA 112
>gi|70166430 GRINL1A combined protein isoform 2 [Homo sapiens]
Length = 445
Score = 39.3 bits (90), Expect = 0.002
Identities = 30/136 (22%), Positives = 67/136 (49%), Gaps = 5/136 (3%)
Query: 8 HVRICNQEIVKFDLEVKALIQDIRDCSGPLSALTELNTKVKEKFQQLRHRIQDLEQLAKE 67
H++ + + +F+ AL D L +T N+ +K++ + L Q + + +
Sbjct: 149 HIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNL----QQTYEASMD 204
Query: 68 QDKESEKQLLLQEVENHKKQMLRKTTKESLAQTSSTITESLMGISRMMAQQVQQSEEA-M 126
+ +E ++QL + +VEN +M ++++E+ A+ +T+ L Q+ Q+ A
Sbjct: 205 KLREKQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEK 264
Query: 127 QSLVTSSRTILDANEE 142
++L+ + + L A EE
Sbjct: 265 EALLEETNSFLKAIEE 280
Score = 27.7 bits (60), Expect = 6.4
Identities = 23/87 (26%), Positives = 41/87 (47%), Gaps = 6/87 (6%)
Query: 62 EQLAKEQDKES-EKQLLLQEVENHKKQMLRKTTKESLAQTSSTITESLMG-----ISRMM 115
E+L +EQ K S EK+ LL+E + K + K A+ S + +G I RM
Sbjct: 251 EKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERME 310
Query: 116 AQQVQQSEEAMQSLVTSSRTILDANEE 142
++ Q + ++ S + D+++E
Sbjct: 311 KERHQLQLQLLEHETEMSGELTDSDKE 337
>gi|70166414 GRINL1A combined protein isoform 1 [Homo sapiens]
Length = 550
Score = 39.3 bits (90), Expect = 0.002
Identities = 30/136 (22%), Positives = 67/136 (49%), Gaps = 5/136 (3%)
Query: 8 HVRICNQEIVKFDLEVKALIQDIRDCSGPLSALTELNTKVKEKFQQLRHRIQDLEQLAKE 67
H++ + + +F+ AL D L +T N+ +K++ + L Q + + +
Sbjct: 149 HIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNL----QQTYEASMD 204
Query: 68 QDKESEKQLLLQEVENHKKQMLRKTTKESLAQTSSTITESLMGISRMMAQQVQQSEEA-M 126
+ +E ++QL + +VEN +M ++++E+ A+ +T+ L Q+ Q+ A
Sbjct: 205 KLREKQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEK 264
Query: 127 QSLVTSSRTILDANEE 142
++L+ + + L A EE
Sbjct: 265 EALLEETNSFLKAIEE 280
Score = 27.7 bits (60), Expect = 6.4
Identities = 23/87 (26%), Positives = 41/87 (47%), Gaps = 6/87 (6%)
Query: 62 EQLAKEQDKES-EKQLLLQEVENHKKQMLRKTTKESLAQTSSTITESLMG-----ISRMM 115
E+L +EQ K S EK+ LL+E + K + K A+ S + +G I RM
Sbjct: 251 EKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERME 310
Query: 116 AQQVQQSEEAMQSLVTSSRTILDANEE 142
++ Q + ++ S + D+++E
Sbjct: 311 KERHQLQLQLLEHETEMSGELTDSDKE 337
>gi|111494235 GRINL1A combined protein isoform 8 [Homo sapiens]
Length = 438
Score = 39.3 bits (90), Expect = 0.002
Identities = 30/136 (22%), Positives = 67/136 (49%), Gaps = 5/136 (3%)
Query: 8 HVRICNQEIVKFDLEVKALIQDIRDCSGPLSALTELNTKVKEKFQQLRHRIQDLEQLAKE 67
H++ + + +F+ AL D L +T N+ +K++ + L Q + + +
Sbjct: 149 HIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNL----QQTYEASMD 204
Query: 68 QDKESEKQLLLQEVENHKKQMLRKTTKESLAQTSSTITESLMGISRMMAQQVQQSEEA-M 126
+ +E ++QL + +VEN +M ++++E+ A+ +T+ L Q+ Q+ A
Sbjct: 205 KLREKQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEK 264
Query: 127 QSLVTSSRTILDANEE 142
++L+ + + L A EE
Sbjct: 265 EALLEETNSFLKAIEE 280
Score = 27.7 bits (60), Expect = 6.4
Identities = 23/87 (26%), Positives = 41/87 (47%), Gaps = 6/87 (6%)
Query: 62 EQLAKEQDKES-EKQLLLQEVENHKKQMLRKTTKESLAQTSSTITESLMG-----ISRMM 115
E+L +EQ K S EK+ LL+E + K + K A+ S + +G I RM
Sbjct: 251 EKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERME 310
Query: 116 AQQVQQSEEAMQSLVTSSRTILDANEE 142
++ Q + ++ S + D+++E
Sbjct: 311 KERHQLQLQLLEHETEMSGELTDSDKE 337
>gi|70166580 GRINL1A upstream protein isoform 7 [Homo sapiens]
Length = 466
Score = 39.3 bits (90), Expect = 0.002
Identities = 30/136 (22%), Positives = 67/136 (49%), Gaps = 5/136 (3%)
Query: 8 HVRICNQEIVKFDLEVKALIQDIRDCSGPLSALTELNTKVKEKFQQLRHRIQDLEQLAKE 67
H++ + + +F+ AL D L +T N+ +K++ + L Q + + +
Sbjct: 149 HIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNL----QQTYEASMD 204
Query: 68 QDKESEKQLLLQEVENHKKQMLRKTTKESLAQTSSTITESLMGISRMMAQQVQQSEEA-M 126
+ +E ++QL + +VEN +M ++++E+ A+ +T+ L Q+ Q+ A
Sbjct: 205 KLREKQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEK 264
Query: 127 QSLVTSSRTILDANEE 142
++L+ + + L A EE
Sbjct: 265 EALLEETNSFLKAIEE 280
Score = 27.7 bits (60), Expect = 6.4
Identities = 23/87 (26%), Positives = 41/87 (47%), Gaps = 6/87 (6%)
Query: 62 EQLAKEQDKES-EKQLLLQEVENHKKQMLRKTTKESLAQTSSTITESLMG-----ISRMM 115
E+L +EQ K S EK+ LL+E + K + K A+ S + +G I RM
Sbjct: 251 EKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERME 310
Query: 116 AQQVQQSEEAMQSLVTSSRTILDANEE 142
++ Q + ++ S + D+++E
Sbjct: 311 KERHQLQLQLLEHETEMSGELTDSDKE 337
>gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]
Length = 1946
Score = 38.9 bits (89), Expect = 0.003
Identities = 37/168 (22%), Positives = 76/168 (45%), Gaps = 15/168 (8%)
Query: 17 VKFDLEVKALIQDIRDCSGPLSALTELNTKVKEKFQQLRHRIQDLEQLAKEQDKES---- 72
++ + VK L + + + S LT K++++ +L+ I DLE + + +KE
Sbjct: 925 IQLEARVKELSERVEEEEEINSELTARGRKLEDECFELKKEIDDLETMLVKSEKEKRTTE 984
Query: 73 -EKQLLLQEVE-----NHKKQMLRKTTKESLAQTSSTI---TESLMGISRMMAQQVQQSE 123
+ + L +EVE K K +E+ QT + E L +S+ + QQ +
Sbjct: 985 HKVKNLTEEVEFLNEDISKLNRAAKVVQEAHQQTLDDLHMEEEKLSSLSKANLKLEQQVD 1044
Query: 124 EAMQSLVTSSRTILDANEEFKSMSGTIQLGRKLI--TKYNRRELTDKL 169
E +L + ++ E + G ++L R+ + + ++R L ++L
Sbjct: 1045 ELEGALEQERKARMNCERELHKLEGNLKLNRESMENLESSQRHLAEEL 1092
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 38.5 bits (88), Expect = 0.004
Identities = 38/156 (24%), Positives = 84/156 (53%), Gaps = 16/156 (10%)
Query: 15 EIVKFDLEVKALIQ---DIRDCSGPLSALTELNTKVKEKFQQLRHRIQDLEQLAKEQDKE 71
++ K +L++ L + ++ + SG L A +L ++E ++ + R Q L K+ D E
Sbjct: 1296 KVRKLELDILPLQEANAELSEKSGMLQAEKKL---LEEDVKRWKARNQHLVSQQKDPDTE 1352
Query: 72 SEKQLLLQEVENHKKQMLRKTT-----KESLAQTSSTIT--ESLMGISRMMAQQVQQSEE 124
E + LL E E H K++ + T K +A++++++T ++L+ + +V+ +E
Sbjct: 1353 -EYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKE 1411
Query: 125 AMQSLVTSSRTILDANEEFKSMSGTIQLGRKLITKY 160
+Q + + I+D E+ K+++ ++GR+ T+Y
Sbjct: 1412 TIQKDLDAK--IIDIQEKVKTITQVKKIGRRYKTQY 1445
Score = 36.6 bits (83), Expect = 0.014
Identities = 24/106 (22%), Positives = 51/106 (48%), Gaps = 5/106 (4%)
Query: 59 QDLEQLAKEQDKESEK-QLLLQEVENHKKQMLRKTTKESLAQTSSTITESLMGISRMMAQ 117
++L++L + E EK Q+ + + H++ M + T + +T+ + E + Q
Sbjct: 1233 RELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREE----KERLEQ 1288
Query: 118 QVQQSEEAMQSLVTSSRTILDANEEFKSMSGTIQLGRKLITKYNRR 163
+QQ + ++ L + +AN E SG +Q +KL+ + +R
Sbjct: 1289 DLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKR 1334
Score = 34.3 bits (77), Expect = 0.068
Identities = 26/136 (19%), Positives = 63/136 (46%), Gaps = 3/136 (2%)
Query: 9 VRICNQEIVKFDLEVKALIQDIRDCSGPLSALTELNTKVKEKFQQLRHRIQDLEQLAKEQ 68
+R +++ +K ++ +++L E K K+ +++R I+ + + E
Sbjct: 941 LRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEF 1000
Query: 69 DKESEKQLLLQEVENHKKQMLRKTTKESLAQTSSTITESLMGISRMMAQQVQQSEEAMQS 128
+ EK+L+ E E + Q ++ ES+ Q S + ++L + + + +Q++ A+ +
Sbjct: 1001 QTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSN 1060
Query: 129 LVTSSRTILDANEEFK 144
+ R D E+ K
Sbjct: 1061 EQQARR---DCQEQAK 1073
Score = 27.3 bits (59), Expect = 8.4
Identities = 29/142 (20%), Positives = 59/142 (41%), Gaps = 26/142 (18%)
Query: 41 TELNTKVKEKFQQLRHRIQDLEQLAKEQDKESEKQLLLQEVE----NHKKQM-----LRK 91
TE ++ + ++L H I L++ K +++ ++ L + ++ + K+Q+ L
Sbjct: 831 TETKQRLSSQIEKLEHEISHLKK--KLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHL 888
Query: 92 TTKESLAQTSSTITESLMGISRMMAQQVQQS-----------EEAMQSLVTSSR----TI 136
TKE L I +S M Q QS +E + LV+ R +
Sbjct: 889 NTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQV 948
Query: 137 LDANEEFKSMSGTIQLGRKLIT 158
D E K+ + ++ + ++T
Sbjct: 949 NDLKERLKTSTSNVEQYQAMVT 970
>gi|116256445 nuclear receptor co-repressor 2 isoform 2 [Homo
sapiens]
Length = 2462
Score = 38.1 bits (87), Expect = 0.005
Identities = 33/129 (25%), Positives = 65/129 (50%), Gaps = 15/129 (11%)
Query: 48 KEKFQQLRHRIQDLEQLAKEQDKESEKQLLLQEVENHKKQMLRKTT----------KESL 97
+++ QQ R E+ KE++KE+EK+ EVEN K+ +L++ T KE++
Sbjct: 505 QQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVENDKEDLLKEKTDDTSGEDNDEKEAV 564
Query: 98 A----QTSSTITESLMGISRMMAQQVQQSEEAMQSLVTSSRTILDANEEFKSMSGTIQLG 153
A +T+++ I+R MA + SEEA+ ++ ++ NE + ++
Sbjct: 565 ASKGRKTANSQGRRKGRITRSMANEA-NSEEAITPQQSAELASMELNESSRWTEEEMETA 623
Query: 154 RKLITKYNR 162
+K + ++ R
Sbjct: 624 KKGLLEHGR 632
>gi|116256453 nuclear receptor co-repressor 2 isoform 1 [Homo
sapiens]
Length = 2524
Score = 38.1 bits (87), Expect = 0.005
Identities = 33/129 (25%), Positives = 65/129 (50%), Gaps = 15/129 (11%)
Query: 48 KEKFQQLRHRIQDLEQLAKEQDKESEKQLLLQEVENHKKQMLRKTT----------KESL 97
+++ QQ R E+ KE++KE+EK+ EVEN K+ +L++ T KE++
Sbjct: 505 QQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVENDKEDLLKEKTDDTSGEDNDEKEAV 564
Query: 98 A----QTSSTITESLMGISRMMAQQVQQSEEAMQSLVTSSRTILDANEEFKSMSGTIQLG 153
A +T+++ I+R MA + SEEA+ ++ ++ NE + ++
Sbjct: 565 ASKGRKTANSQGRRKGRITRSMANEA-NSEEAITPQQSAELASMELNESSRWTEEEMETA 623
Query: 154 RKLITKYNR 162
+K + ++ R
Sbjct: 624 KKGLLEHGR 632
>gi|148613880 hypothetical protein LOC145773 [Homo sapiens]
Length = 368
Score = 38.1 bits (87), Expect = 0.005
Identities = 46/172 (26%), Positives = 74/172 (43%), Gaps = 39/172 (22%)
Query: 14 QEIVKFDLEVKALIQDIRDCSGPLSAL--------TELNTKVKEKFQQLRHRIQDLEQLA 65
Q+ K LE K I+D G +S L +E +TK+K + H++Q L+
Sbjct: 164 QQAAKLILETK-----IKDAEGQISQLLNRVDLSISEQSTKLKMSHRDSNHQLQLLDTKF 218
Query: 66 KEQDKESEKQL------LLQEVENHKKQMLRKTTKESL-AQTSSTITESLM--GISRMMA 116
K +E Q+ L QE E +K++L+K + SL + +S +E M +S+M A
Sbjct: 219 KGTVEELSNQILSARSWLQQEQERIEKELLQKIDQLSLIVKENSGASERDMEKKLSQMSA 278
Query: 117 ---------------QQVQQSEEAMQSLVTSSRTILDANEEFKSMSGTIQLG 153
Q+ +Q EE M +T + L N+ K M + G
Sbjct: 279 RLDKIEEGQKKTFDGQRTRQEEEKMHGRIT--KLELQMNQNIKEMKAEVNAG 328
>gi|109255234 centrosomal protein 290kDa [Homo sapiens]
Length = 2479
Score = 37.4 bits (85), Expect = 0.008
Identities = 35/165 (21%), Positives = 72/165 (43%), Gaps = 20/165 (12%)
Query: 7 VHVRICNQEIVKFDLEVKALIQDIRDCSGPLSALTELNTKVKEKFQQLRHRIQDLEQLA- 65
V ++ C +I D E++ L ++I +S + N ++E+ + DL +
Sbjct: 463 VEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVGLEPKTMIDLTEFRN 522
Query: 66 ----KEQDKESEKQLLLQEVE-------NHKKQMLRKTTKESLAQTSSTITESLMGISRM 114
K+Q +E Q+LL+E+E + KK++ + + +S +T + ++
Sbjct: 523 SKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTEN 582
Query: 115 MAQQVQQSEEAMQSLVTSSRTILDANEEFKSMSGTIQLGRKLITK 159
++Q + SE + L + + + EF L R+LI K
Sbjct: 583 ISQGDRISERKLDLLSLKNMSEAQSKNEF--------LSRELIEK 619
Score = 32.7 bits (73), Expect = 0.20
Identities = 24/80 (30%), Positives = 42/80 (52%), Gaps = 10/80 (12%)
Query: 9 VRICNQEIVKFDLEVKALIQDIRDCSGPLSALTELNTKVKEKFQQLRHRIQDLEQLAKEQ 68
+R+ N ++ K E+ I+ +D SG S + + + QL+ +I+DLE K
Sbjct: 2344 LRLANHQLDKEKAELIHQIEANKDQSGAESTIPDAD--------QLKEKIKDLETQLKMS 2395
Query: 69 DKESEKQLLLQEVENHKKQM 88
D EKQ L +E++ KK++
Sbjct: 2396 D--LEKQHLKEEIKKLKKEL 2413
Score = 32.3 bits (72), Expect = 0.26
Identities = 33/148 (22%), Positives = 68/148 (45%), Gaps = 29/148 (19%)
Query: 43 LNTKVKEKFQQLRHRIQDLEQLAKEQDKESE--KQLLL--QEVENHKKQMLRK------- 91
L ++ + +QL + ++LE + KE +KE + +QL L +E EN ++ R+
Sbjct: 113 LRNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKK 172
Query: 92 ----------------TTKESLAQTSSTITESLMGISRMMAQQVQQSEEAMQSLVTSSRT 135
+ KE+L ++ +S+ + +Q +E +Q+L ++
Sbjct: 173 NEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDE-IQTLTEANEK 231
Query: 136 ILDANEEF-KSMSGTIQLGRKLITKYNR 162
I N+E K++ ++Q K+ +YNR
Sbjct: 232 IEVQNQEMRKNLEESVQEMEKMTDEYNR 259
Score = 27.3 bits (59), Expect = 8.4
Identities = 18/82 (21%), Positives = 37/82 (45%), Gaps = 4/82 (4%)
Query: 5 QDVHVRICNQEIVKFDLEVKALIQDIRDCSGPLSALTELNTKVKEKFQQLRHRIQDLEQL 64
+D +++ +++ ++ E++ I D L + N QQ +IQ +
Sbjct: 360 RDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNEL----QRNKGASTLSQQTHMKIQSTLDI 415
Query: 65 AKEQDKESEKQLLLQEVENHKK 86
KE+ KE+E+ L E + +K
Sbjct: 416 LKEKTKEAERTAELAEADAREK 437
>gi|56550047 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 2 [Homo sapiens]
Length = 1403
Score = 37.4 bits (85), Expect = 0.008
Identities = 31/149 (20%), Positives = 61/149 (40%), Gaps = 22/149 (14%)
Query: 14 QEIVKFDLEVKALIQDIRDCSGPLSALTELNTKVKEKFQQLRHRIQDLEQLAKEQDKESE 73
QE K E+ L +D+RD + + E+ + K +L +++DL Q E
Sbjct: 1015 QENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEV----- 1069
Query: 74 KQLLLQEVENHKKQMLRKTTKESLAQTSSTITESLMGISRMMAQQVQQSEEAMQSLVTSS 133
K KE L + ++ T ++ + ++ +Q E+ + +
Sbjct: 1070 -----------------KNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLN 1112
Query: 134 RTILDANEEFKSMSGTIQLGRKLITKYNR 162
TI + EE KSM + ++ +TK ++
Sbjct: 1113 GTIENLKEELKSMQRCYEKEQQTVTKLHQ 1141
Score = 33.1 bits (74), Expect = 0.15
Identities = 28/150 (18%), Positives = 73/150 (48%), Gaps = 12/150 (8%)
Query: 26 LIQDIRDCSGPLSALTELNTKVKEKFQQLRHRIQDLEQLAKEQDKESEKQLLLQEVENHK 85
L+++ ++ S PL+ ++ +++ ++ +++ E+ + Q+K E L EV+N K
Sbjct: 1142 LLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEE--ESQNKMEEVSKLQSEVQNTK 1199
Query: 86 KQMLRKTTKE-----SLAQTSSTITESLMGISRMMAQQVQQSEEAMQSLVTSSRTILDAN 140
+ + + T+E T S + + ++ +A ++ EE + ++ + + + A
Sbjct: 1200 QALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAK 1259
Query: 141 EEFKSMSGTIQLGRKLITKYNRRELTDKLL 170
+E + + +I+ K +++E DK L
Sbjct: 1260 DEKELLHFSIEQEIK-----DQKERCDKSL 1284
Score = 28.5 bits (62), Expect = 3.7
Identities = 32/161 (19%), Positives = 72/161 (44%), Gaps = 11/161 (6%)
Query: 18 KFDLEVKALIQDIRDCSGPLSALTELNTKVKEKFQQLRHRIQDLEQLAKEQDKESEKQLL 77
KF+ +L ++ + + L + + K + +QL+ +++++ + K E + +
Sbjct: 618 KFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQV 677
Query: 78 LQEVENHKKQMLRKTTKESLA-QTSSTITESLMGISRMMAQQVQQSEEAMQSLVTSSRTI 136
+E ++ +K T+ +L QT E + ++++ +Q M++
Sbjct: 678 KSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVP---- 733
Query: 137 LDANEEFKSMSGTI--QLGRKLI---TKYNRREL-TDKLLI 171
L +E+ K I L RKL+ KY ++L +KLL+
Sbjct: 734 LKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLL 774
Score = 28.1 bits (61), Expect = 4.9
Identities = 30/134 (22%), Positives = 59/134 (44%), Gaps = 26/134 (19%)
Query: 40 LTELNTKVKEKFQQLRHRIQDLEQLAKEQDKESEKQLLLQEV----ENHKKQM--LRKTT 93
+ +LN K+ + Q+ + ++E+L E D S+ L+ V E H+K++ L+
Sbjct: 748 IDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNI 807
Query: 94 KESLAQTSS-------------TITESLMGISRMMAQQ---VQQSEEAM----QSLVTSS 133
E Q S +T + +MM+ Q V+ EE +L ++
Sbjct: 808 VELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTN 867
Query: 134 RTILDANEEFKSMS 147
R +LD ++F+ ++
Sbjct: 868 RELLDVKKKFEDIN 881
>gi|59850762 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 1 [Homo sapiens]
Length = 1416
Score = 37.4 bits (85), Expect = 0.008
Identities = 31/149 (20%), Positives = 61/149 (40%), Gaps = 22/149 (14%)
Query: 14 QEIVKFDLEVKALIQDIRDCSGPLSALTELNTKVKEKFQQLRHRIQDLEQLAKEQDKESE 73
QE K E+ L +D+RD + + E+ + K +L +++DL Q E
Sbjct: 1028 QENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEV----- 1082
Query: 74 KQLLLQEVENHKKQMLRKTTKESLAQTSSTITESLMGISRMMAQQVQQSEEAMQSLVTSS 133
K KE L + ++ T ++ + ++ +Q E+ + +
Sbjct: 1083 -----------------KNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLN 1125
Query: 134 RTILDANEEFKSMSGTIQLGRKLITKYNR 162
TI + EE KSM + ++ +TK ++
Sbjct: 1126 GTIENLKEELKSMQRCYEKEQQTVTKLHQ 1154
Score = 33.1 bits (74), Expect = 0.15
Identities = 28/150 (18%), Positives = 73/150 (48%), Gaps = 12/150 (8%)
Query: 26 LIQDIRDCSGPLSALTELNTKVKEKFQQLRHRIQDLEQLAKEQDKESEKQLLLQEVENHK 85
L+++ ++ S PL+ ++ +++ ++ +++ E+ + Q+K E L EV+N K
Sbjct: 1155 LLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEE--ESQNKMEEVSKLQSEVQNTK 1212
Query: 86 KQMLRKTTKE-----SLAQTSSTITESLMGISRMMAQQVQQSEEAMQSLVTSSRTILDAN 140
+ + + T+E T S + + ++ +A ++ EE + ++ + + + A
Sbjct: 1213 QALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAK 1272
Query: 141 EEFKSMSGTIQLGRKLITKYNRRELTDKLL 170
+E + + +I+ K +++E DK L
Sbjct: 1273 DEKELLHFSIEQEIK-----DQKERCDKSL 1297
Score = 28.5 bits (62), Expect = 3.7
Identities = 32/161 (19%), Positives = 72/161 (44%), Gaps = 11/161 (6%)
Query: 18 KFDLEVKALIQDIRDCSGPLSALTELNTKVKEKFQQLRHRIQDLEQLAKEQDKESEKQLL 77
KF+ +L ++ + + L + + K + +QL+ +++++ + K E + +
Sbjct: 631 KFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQV 690
Query: 78 LQEVENHKKQMLRKTTKESLA-QTSSTITESLMGISRMMAQQVQQSEEAMQSLVTSSRTI 136
+E ++ +K T+ +L QT E + ++++ +Q M++
Sbjct: 691 KSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVP---- 746
Query: 137 LDANEEFKSMSGTI--QLGRKLI---TKYNRREL-TDKLLI 171
L +E+ K I L RKL+ KY ++L +KLL+
Sbjct: 747 LKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLL 787
Score = 28.1 bits (61), Expect = 4.9
Identities = 30/134 (22%), Positives = 59/134 (44%), Gaps = 26/134 (19%)
Query: 40 LTELNTKVKEKFQQLRHRIQDLEQLAKEQDKESEKQLLLQEV----ENHKKQM--LRKTT 93
+ +LN K+ + Q+ + ++E+L E D S+ L+ V E H+K++ L+
Sbjct: 761 IDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNI 820
Query: 94 KESLAQTSS-------------TITESLMGISRMMAQQ---VQQSEEAM----QSLVTSS 133
E Q S +T + +MM+ Q V+ EE +L ++
Sbjct: 821 VELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTN 880
Query: 134 RTILDANEEFKSMS 147
R +LD ++F+ ++
Sbjct: 881 RELLDVKKKFEDIN 894
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.130 0.337
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 5,407,783
Number of Sequences: 37866
Number of extensions: 195325
Number of successful extensions: 3311
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 123
Number of HSP's successfully gapped in prelim test: 415
Number of HSP's that attempted gapping in prelim test: 2323
Number of HSP's gapped (non-prelim): 1309
length of query: 194
length of database: 18,247,518
effective HSP length: 97
effective length of query: 97
effective length of database: 14,574,516
effective search space: 1413728052
effective search space used: 1413728052
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 59 (27.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.