BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|153792195 DKFZP434H0735 protein [Homo sapiens] (1639 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|153792195 DKFZP434H0735 protein [Homo sapiens] 3319 0.0 gi|191252814 RIMS binding protein 3B [Homo sapiens] 3295 0.0 gi|191252806 RIMS binding protein 3C [Homo sapiens] 3294 0.0 gi|171906559 peripheral benzodiazepine receptor-associated prote... 369 e-101 gi|171906567 peripheral benzodiazepine receptor-associated prote... 268 2e-71 gi|140561070 RIM-binding protein 2 [Homo sapiens] 212 3e-54 gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 79 4e-14 gi|41322923 plectin 1 isoform 11 [Homo sapiens] 74 2e-12 gi|41322914 plectin 1 isoform 10 [Homo sapiens] 74 2e-12 gi|41322919 plectin 1 isoform 8 [Homo sapiens] 74 2e-12 gi|41322910 plectin 1 isoform 7 [Homo sapiens] 74 2e-12 gi|41322916 plectin 1 isoform 6 [Homo sapiens] 74 2e-12 gi|41322908 plectin 1 isoform 3 [Homo sapiens] 74 2e-12 gi|41322912 plectin 1 isoform 2 [Homo sapiens] 74 2e-12 gi|47607492 plectin 1 isoform 1 [Homo sapiens] 74 2e-12 gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 72 4e-12 gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 70 1e-11 gi|56549694 enabled homolog isoform a [Homo sapiens] 62 5e-09 gi|39930375 enabled homolog isoform b [Homo sapiens] 62 5e-09 gi|157502225 Janus kinase and microtubule interacting protein 3 ... 62 6e-09 gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap... 61 1e-08 gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap... 61 1e-08 gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap... 61 1e-08 gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapi... 61 1e-08 gi|148746195 trichohyalin [Homo sapiens] 60 2e-08 gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa... 58 7e-08 gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa... 58 7e-08 gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa... 58 7e-08 gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap... 58 7e-08 gi|41152097 DNA segment on chromosome X and Y (unique) 155 expre... 57 1e-07 >gi|153792195 DKFZP434H0735 protein [Homo sapiens] Length = 1639 Score = 3319 bits (8606), Expect = 0.0 Identities = 1639/1639 (100%), Positives = 1639/1639 (100%) Query: 1 MAKDSPSPLGASPKKPGCSSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQ 60 MAKDSPSPLGASPKKPGCSSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQ Sbjct: 1 MAKDSPSPLGASPKKPGCSSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQ 60 Query: 61 LREEAERERRQLADRLRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQL 120 LREEAERERRQLADRLRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQL Sbjct: 61 LREEAERERRQLADRLRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQL 120 Query: 121 LHRERDGVVRQARELQRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGE 180 LHRERDGVVRQARELQRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGE Sbjct: 121 LHRERDGVVRQARELQRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGE 180 Query: 181 QAARIRYLQAALEVERQLFLKYILAHFRGHPALSGSPDPQAVHSLEEPLPQTSSGSCHAP 240 QAARIRYLQAALEVERQLFLKYILAHFRGHPALSGSPDPQAVHSLEEPLPQTSSGSCHAP Sbjct: 181 QAARIRYLQAALEVERQLFLKYILAHFRGHPALSGSPDPQAVHSLEEPLPQTSSGSCHAP 240 Query: 241 KPACQLGSLDSLSAEVGVRSRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTR 300 KPACQLGSLDSLSAEVGVRSRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTR Sbjct: 241 KPACQLGSLDSLSAEVGVRSRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTR 300 Query: 301 SLPKASKSEERPSSPDTSTPGSRRLSPPPSPLPPPPPPSAHRKLSNPRGGEGSESQPCEV 360 SLPKASKSEERPSSPDTSTPGSRRLSPPPSPLPPPPPPSAHRKLSNPRGGEGSESQPCEV Sbjct: 301 SLPKASKSEERPSSPDTSTPGSRRLSPPPSPLPPPPPPSAHRKLSNPRGGEGSESQPCEV 360 Query: 361 LTPSPPGLGHHELIKLNWLLAKALWVLARRCYTLQAENKQLRRAGCPYQADEKVKRLKVK 420 LTPSPPGLGHHELIKLNWLLAKALWVLARRCYTLQAENKQLRRAGCPYQADEKVKRLKVK Sbjct: 361 LTPSPPGLGHHELIKLNWLLAKALWVLARRCYTLQAENKQLRRAGCPYQADEKVKRLKVK 420 Query: 421 RAELTGLARRLADRARKLQETNLRAVSAPIPGESCAGLELCQVFARQRARDLSEQASAPL 480 RAELTGLARRLADRARKLQETNLRAVSAPIPGESCAGLELCQVFARQRARDLSEQASAPL Sbjct: 421 RAELTGLARRLADRARKLQETNLRAVSAPIPGESCAGLELCQVFARQRARDLSEQASAPL 480 Query: 481 AKDKQIEELRQECHLLQARVASGPCSDLHTGRGGPCTQWLNVRDLDRLQRESQREVLRLQ 540 AKDKQIEELRQECHLLQARVASGPCSDLHTGRGGPCTQWLNVRDLDRLQRESQREVLRLQ Sbjct: 481 AKDKQIEELRQECHLLQARVASGPCSDLHTGRGGPCTQWLNVRDLDRLQRESQREVLRLQ 540 Query: 541 RQLMLQQGNGGAWPEAGGQSATCEEVRRQMLALERELDQRRRECQELGAQAAPARRRGEE 600 RQLMLQQGNGGAWPEAGGQSATCEEVRRQMLALERELDQRRRECQELGAQAAPARRRGEE Sbjct: 541 RQLMLQQGNGGAWPEAGGQSATCEEVRRQMLALERELDQRRRECQELGAQAAPARRRGEE 600 Query: 601 AETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLGRACQERDASGLIAEQL 660 AETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLGRACQERDASGLIAEQL Sbjct: 601 AETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLGRACQERDASGLIAEQL 660 Query: 661 LQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQVKGS 720 LQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQVKGS Sbjct: 661 LQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQVKGS 720 Query: 721 RRPKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQVSETVPASQPLSKKTS 780 RRPKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQVSETVPASQPLSKKTS Sbjct: 721 RRPKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQVSETVPASQPLSKKTS 780 Query: 781 SQSNSSSEGSMWATVPSSPTLDRDTASEVDDLEPDSVSLALEMGGSAAPAAPKLKIFMAQ 840 SQSNSSSEGSMWATVPSSPTLDRDTASEVDDLEPDSVSLALEMGGSAAPAAPKLKIFMAQ Sbjct: 781 SQSNSSSEGSMWATVPSSPTLDRDTASEVDDLEPDSVSLALEMGGSAAPAAPKLKIFMAQ 840 Query: 841 YNYNPFEGPNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELEDGRRGLVPSNFVEQIPDS 900 YNYNPFEGPNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELEDGRRGLVPSNFVEQIPDS Sbjct: 841 YNYNPFEGPNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELEDGRRGLVPSNFVEQIPDS 900 Query: 901 YIPGCLPAKSPDLGPSQLPAGQDEALEEDSLLSGKAQGVVDRGLCQMVRVGSKTEVATEI 960 YIPGCLPAKSPDLGPSQLPAGQDEALEEDSLLSGKAQGVVDRGLCQMVRVGSKTEVATEI Sbjct: 901 YIPGCLPAKSPDLGPSQLPAGQDEALEEDSLLSGKAQGVVDRGLCQMVRVGSKTEVATEI 960 Query: 961 LDTKTEACQLGLLQSMGKQGLSRPLLGTKGVLRMAPMQLHLQNVTATSANITWVYSSHRH 1020 LDTKTEACQLGLLQSMGKQGLSRPLLGTKGVLRMAPMQLHLQNVTATSANITWVYSSHRH Sbjct: 961 LDTKTEACQLGLLQSMGKQGLSRPLLGTKGVLRMAPMQLHLQNVTATSANITWVYSSHRH 1020 Query: 1021 PHVVYLDDREHALTPAGVSCYTFQGLCPGTHYRARVEVRLPRDLLQVYWGTMSSTVTFDT 1080 PHVVYLDDREHALTPAGVSCYTFQGLCPGTHYRARVEVRLPRDLLQVYWGTMSSTVTFDT Sbjct: 1021 PHVVYLDDREHALTPAGVSCYTFQGLCPGTHYRARVEVRLPRDLLQVYWGTMSSTVTFDT 1080 Query: 1081 LLAGPPYPPLDVLVERHASPGVLVVSWLPVTIDSAGSSNGVQVTGYAVYADGLKVCEVAD 1140 LLAGPPYPPLDVLVERHASPGVLVVSWLPVTIDSAGSSNGVQVTGYAVYADGLKVCEVAD Sbjct: 1081 LLAGPPYPPLDVLVERHASPGVLVVSWLPVTIDSAGSSNGVQVTGYAVYADGLKVCEVAD 1140 Query: 1141 ATAGSTLLEFSQLQVPLTWQKVSVRTMSLCGESLDSVPAQIPEDFFMCHRWPETPPFSYT 1200 ATAGSTLLEFSQLQVPLTWQKVSVRTMSLCGESLDSVPAQIPEDFFMCHRWPETPPFSYT Sbjct: 1141 ATAGSTLLEFSQLQVPLTWQKVSVRTMSLCGESLDSVPAQIPEDFFMCHRWPETPPFSYT 1200 Query: 1201 CGDPSTYRVTFPVCPQKLSLAPPSAKASPHNPGSCGEPQAKFLEAFFEEPPRRQSPVSNL 1260 CGDPSTYRVTFPVCPQKLSLAPPSAKASPHNPGSCGEPQAKFLEAFFEEPPRRQSPVSNL Sbjct: 1201 CGDPSTYRVTFPVCPQKLSLAPPSAKASPHNPGSCGEPQAKFLEAFFEEPPRRQSPVSNL 1260 Query: 1261 GSEGECPSSGAGSQAQELAEAWEGCRKDLLFQKSPQNHRPPSVSDQPGEKENCSQHMGTS 1320 GSEGECPSSGAGSQAQELAEAWEGCRKDLLFQKSPQNHRPPSVSDQPGEKENCSQHMGTS Sbjct: 1261 GSEGECPSSGAGSQAQELAEAWEGCRKDLLFQKSPQNHRPPSVSDQPGEKENCSQHMGTS 1320 Query: 1321 KSPAPGFIHLRTECGPRKEPCQEKAALERVLRQKQDAQGFTPPQLGASQQYASDFHNVLK 1380 KSPAPGFIHLRTECGPRKEPCQEKAALERVLRQKQDAQGFTPPQLGASQQYASDFHNVLK Sbjct: 1321 KSPAPGFIHLRTECGPRKEPCQEKAALERVLRQKQDAQGFTPPQLGASQQYASDFHNVLK 1380 Query: 1381 EEQEALCLDLWGTERREERREPEPHSRQGQALGVKRGCQLHEPSSALCPAPSAKVIKMPR 1440 EEQEALCLDLWGTERREERREPEPHSRQGQALGVKRGCQLHEPSSALCPAPSAKVIKMPR Sbjct: 1381 EEQEALCLDLWGTERREERREPEPHSRQGQALGVKRGCQLHEPSSALCPAPSAKVIKMPR 1440 Query: 1441 GGPQQLGTGANTPARVFVALSDYNPLVMSANLKAAEEELVFQKRQLLRVWGSQDTHDFYL 1500 GGPQQLGTGANTPARVFVALSDYNPLVMSANLKAAEEELVFQKRQLLRVWGSQDTHDFYL Sbjct: 1441 GGPQQLGTGANTPARVFVALSDYNPLVMSANLKAAEEELVFQKRQLLRVWGSQDTHDFYL 1500 Query: 1501 SECNRQVGNIPGRLVAEMEVGTEQTDRRWRSPAQGNLPSVAHLEDFQGLTIPQGSSLVLQ 1560 SECNRQVGNIPGRLVAEMEVGTEQTDRRWRSPAQGNLPSVAHLEDFQGLTIPQGSSLVLQ Sbjct: 1501 SECNRQVGNIPGRLVAEMEVGTEQTDRRWRSPAQGNLPSVAHLEDFQGLTIPQGSSLVLQ 1560 Query: 1561 GNSKRLPLWTPKIMIAALDYDPGDGQMGGQGKGRLALRAGDVVMVYGPMDDQGFYYGELG 1620 GNSKRLPLWTPKIMIAALDYDPGDGQMGGQGKGRLALRAGDVVMVYGPMDDQGFYYGELG Sbjct: 1561 GNSKRLPLWTPKIMIAALDYDPGDGQMGGQGKGRLALRAGDVVMVYGPMDDQGFYYGELG 1620 Query: 1621 GHRGLVPAHLLDHMSLHGH 1639 GHRGLVPAHLLDHMSLHGH Sbjct: 1621 GHRGLVPAHLLDHMSLHGH 1639 >gi|191252814 RIMS binding protein 3B [Homo sapiens] Length = 1639 Score = 3295 bits (8543), Expect = 0.0 Identities = 1627/1639 (99%), Positives = 1633/1639 (99%) Query: 1 MAKDSPSPLGASPKKPGCSSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQ 60 MAKDSPSPLGASPKKPGCSSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQ Sbjct: 1 MAKDSPSPLGASPKKPGCSSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQ 60 Query: 61 LREEAERERRQLADRLRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQL 120 LREEAERERRQLADRLRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQL Sbjct: 61 LREEAERERRQLADRLRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQL 120 Query: 121 LHRERDGVVRQARELQRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGE 180 LHRERDGVVRQARELQRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGE Sbjct: 121 LHRERDGVVRQARELQRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGE 180 Query: 181 QAARIRYLQAALEVERQLFLKYILAHFRGHPALSGSPDPQAVHSLEEPLPQTSSGSCHAP 240 QAARIRYLQAALEVERQLFLKYILAHFRGHPALSGSPDPQAVHSLEEPLPQTSSGSCHAP Sbjct: 181 QAARIRYLQAALEVERQLFLKYILAHFRGHPALSGSPDPQAVHSLEEPLPQTSSGSCHAP 240 Query: 241 KPACQLGSLDSLSAEVGVRSRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTR 300 KPACQLGSLDSLSAEVGVRSRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTR Sbjct: 241 KPACQLGSLDSLSAEVGVRSRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTR 300 Query: 301 SLPKASKSEERPSSPDTSTPGSRRLSPPPSPLPPPPPPSAHRKLSNPRGGEGSESQPCEV 360 SLPKASKSEERPSSPDTSTPGSRRLSPPPSPLPPPPPPSAHRKLSNPRGGEGSESQPCEV Sbjct: 301 SLPKASKSEERPSSPDTSTPGSRRLSPPPSPLPPPPPPSAHRKLSNPRGGEGSESQPCEV 360 Query: 361 LTPSPPGLGHHELIKLNWLLAKALWVLARRCYTLQAENKQLRRAGCPYQADEKVKRLKVK 420 LTPSPPGLGHHELIKLNWLLAKALWVLARRCYTLQ ENKQLRRAGCPYQADEKVKRLKVK Sbjct: 361 LTPSPPGLGHHELIKLNWLLAKALWVLARRCYTLQEENKQLRRAGCPYQADEKVKRLKVK 420 Query: 421 RAELTGLARRLADRARKLQETNLRAVSAPIPGESCAGLELCQVFARQRARDLSEQASAPL 480 RAELTGLARRLADRAR+LQETNLRAVSAPIPGESCAGLELCQVFARQRARDLSEQASAPL Sbjct: 421 RAELTGLARRLADRARELQETNLRAVSAPIPGESCAGLELCQVFARQRARDLSEQASAPL 480 Query: 481 AKDKQIEELRQECHLLQARVASGPCSDLHTGRGGPCTQWLNVRDLDRLQRESQREVLRLQ 540 AKDKQIEELRQECHLLQARVASGPCSDLHTGRGGPCTQWLNVRDLDRLQRESQREVLRLQ Sbjct: 481 AKDKQIEELRQECHLLQARVASGPCSDLHTGRGGPCTQWLNVRDLDRLQRESQREVLRLQ 540 Query: 541 RQLMLQQGNGGAWPEAGGQSATCEEVRRQMLALERELDQRRRECQELGAQAAPARRRGEE 600 RQLMLQQGNGGAWPEAGGQSATCEEVRRQMLALERELDQRRRECQELG QAAPARRRGEE Sbjct: 541 RQLMLQQGNGGAWPEAGGQSATCEEVRRQMLALERELDQRRRECQELGTQAAPARRRGEE 600 Query: 601 AETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLGRACQERDASGLIAEQL 660 AETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLGRACQERDASGLIAEQL Sbjct: 601 AETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLGRACQERDASGLIAEQL 660 Query: 661 LQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQVKGS 720 LQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQVKGS Sbjct: 661 LQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQVKGS 720 Query: 721 RRPKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQVSETVPASQPLSKKTS 780 RRPKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQVSETVPASQPLSKKTS Sbjct: 721 RRPKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQVSETVPASQPLSKKTS 780 Query: 781 SQSNSSSEGSMWATVPSSPTLDRDTASEVDDLEPDSVSLALEMGGSAAPAAPKLKIFMAQ 840 SQSNSSSEGSMWATVPSSPTLDRDTASEVDDLEPDSVSLALEMGGSAAPAAPKLKIFMAQ Sbjct: 781 SQSNSSSEGSMWATVPSSPTLDRDTASEVDDLEPDSVSLALEMGGSAAPAAPKLKIFMAQ 840 Query: 841 YNYNPFEGPNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELEDGRRGLVPSNFVEQIPDS 900 YNYNPFEGPNDHPEGELPLTAGDYIYIFGDMDEDGFYEGEL+DGRRGLVPSNFVEQIPDS Sbjct: 841 YNYNPFEGPNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELDDGRRGLVPSNFVEQIPDS 900 Query: 901 YIPGCLPAKSPDLGPSQLPAGQDEALEEDSLLSGKAQGVVDRGLCQMVRVGSKTEVATEI 960 YIPGCLPAKSPDLGPSQLPAGQDEALEEDSLLSGKAQG+VDRGLCQMVRVGSKTEVATEI Sbjct: 901 YIPGCLPAKSPDLGPSQLPAGQDEALEEDSLLSGKAQGMVDRGLCQMVRVGSKTEVATEI 960 Query: 961 LDTKTEACQLGLLQSMGKQGLSRPLLGTKGVLRMAPMQLHLQNVTATSANITWVYSSHRH 1020 LDTKTEACQLGLLQSMGKQGLSRPLLGTKGVLRMAPMQLHLQNVTATSANITWVYSSHRH Sbjct: 961 LDTKTEACQLGLLQSMGKQGLSRPLLGTKGVLRMAPMQLHLQNVTATSANITWVYSSHRH 1020 Query: 1021 PHVVYLDDREHALTPAGVSCYTFQGLCPGTHYRARVEVRLPRDLLQVYWGTMSSTVTFDT 1080 PHVVYLDDREHALTPAGVSCYTFQGLCPGTHYR RVEVRLP DLLQVYWGTMSSTVTFDT Sbjct: 1021 PHVVYLDDREHALTPAGVSCYTFQGLCPGTHYRVRVEVRLPWDLLQVYWGTMSSTVTFDT 1080 Query: 1081 LLAGPPYPPLDVLVERHASPGVLVVSWLPVTIDSAGSSNGVQVTGYAVYADGLKVCEVAD 1140 LLAGPPYPPL+VLVERHASPGVLVVSWLPVTIDSAGSSNGVQVTGYAVYADGLKVCEVAD Sbjct: 1081 LLAGPPYPPLEVLVERHASPGVLVVSWLPVTIDSAGSSNGVQVTGYAVYADGLKVCEVAD 1140 Query: 1141 ATAGSTLLEFSQLQVPLTWQKVSVRTMSLCGESLDSVPAQIPEDFFMCHRWPETPPFSYT 1200 ATAGST+LEFSQLQVPLTWQKVSVRTMSLCGESLDSVPAQIPEDFFMCHRWPETPPFSYT Sbjct: 1141 ATAGSTVLEFSQLQVPLTWQKVSVRTMSLCGESLDSVPAQIPEDFFMCHRWPETPPFSYT 1200 Query: 1201 CGDPSTYRVTFPVCPQKLSLAPPSAKASPHNPGSCGEPQAKFLEAFFEEPPRRQSPVSNL 1260 CGDPSTYRVTFPVCPQKLSLAPPSAKASPHNPGSCGEPQAKFLEAFFEEPPRRQSPVSNL Sbjct: 1201 CGDPSTYRVTFPVCPQKLSLAPPSAKASPHNPGSCGEPQAKFLEAFFEEPPRRQSPVSNL 1260 Query: 1261 GSEGECPSSGAGSQAQELAEAWEGCRKDLLFQKSPQNHRPPSVSDQPGEKENCSQHMGTS 1320 GSEGECPSSGAGSQAQELAEAWEGCRKDLLFQKSPQNHRPPSVSDQPGEKENC QHMGTS Sbjct: 1261 GSEGECPSSGAGSQAQELAEAWEGCRKDLLFQKSPQNHRPPSVSDQPGEKENCYQHMGTS 1320 Query: 1321 KSPAPGFIHLRTECGPRKEPCQEKAALERVLRQKQDAQGFTPPQLGASQQYASDFHNVLK 1380 KSPAPGFIHLRTECGPRKEPCQEKAALERVLRQKQDAQGFTPPQLGASQQYASDFHNVLK Sbjct: 1321 KSPAPGFIHLRTECGPRKEPCQEKAALERVLRQKQDAQGFTPPQLGASQQYASDFHNVLK 1380 Query: 1381 EEQEALCLDLWGTERREERREPEPHSRQGQALGVKRGCQLHEPSSALCPAPSAKVIKMPR 1440 EEQEALCLDL GTERREERREPEPHSRQGQALGVKRGCQLHEPSSALCPAPSAKVIKMPR Sbjct: 1381 EEQEALCLDLRGTERREERREPEPHSRQGQALGVKRGCQLHEPSSALCPAPSAKVIKMPR 1440 Query: 1441 GGPQQLGTGANTPARVFVALSDYNPLVMSANLKAAEEELVFQKRQLLRVWGSQDTHDFYL 1500 GGPQQLGTGANTPARVFVALSDYNPLVMSANLKAAEEELVFQKRQLLRVWGSQDTHDFYL Sbjct: 1441 GGPQQLGTGANTPARVFVALSDYNPLVMSANLKAAEEELVFQKRQLLRVWGSQDTHDFYL 1500 Query: 1501 SECNRQVGNIPGRLVAEMEVGTEQTDRRWRSPAQGNLPSVAHLEDFQGLTIPQGSSLVLQ 1560 SECNRQVGNIPGRLVAEMEVGTEQTDRRWRSPAQG+LPSVAHLEDFQGLTIPQGSSLVLQ Sbjct: 1501 SECNRQVGNIPGRLVAEMEVGTEQTDRRWRSPAQGHLPSVAHLEDFQGLTIPQGSSLVLQ 1560 Query: 1561 GNSKRLPLWTPKIMIAALDYDPGDGQMGGQGKGRLALRAGDVVMVYGPMDDQGFYYGELG 1620 GNSKRLPLWTPKIMIAALDYDPGDGQMGGQGKGRLALRAGDVVMVYGPMDDQGFYYGELG Sbjct: 1561 GNSKRLPLWTPKIMIAALDYDPGDGQMGGQGKGRLALRAGDVVMVYGPMDDQGFYYGELG 1620 Query: 1621 GHRGLVPAHLLDHMSLHGH 1639 GHRGLVPAHLLDHMSLHGH Sbjct: 1621 GHRGLVPAHLLDHMSLHGH 1639 >gi|191252806 RIMS binding protein 3C [Homo sapiens] Length = 1639 Score = 3294 bits (8541), Expect = 0.0 Identities = 1627/1639 (99%), Positives = 1632/1639 (99%) Query: 1 MAKDSPSPLGASPKKPGCSSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQ 60 MAKDSPSPLGASPKKPGCSSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQ Sbjct: 1 MAKDSPSPLGASPKKPGCSSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQ 60 Query: 61 LREEAERERRQLADRLRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQL 120 LREEAERERRQLADRLRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQL Sbjct: 61 LREEAERERRQLADRLRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQL 120 Query: 121 LHRERDGVVRQARELQRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGE 180 LHRERDGVVRQARELQRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGE Sbjct: 121 LHRERDGVVRQARELQRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGE 180 Query: 181 QAARIRYLQAALEVERQLFLKYILAHFRGHPALSGSPDPQAVHSLEEPLPQTSSGSCHAP 240 QAARIRYLQAALEVERQLFLKYILAHFRGHPALSGSPDPQAVHSLEEPLPQTSSGSCHAP Sbjct: 181 QAARIRYLQAALEVERQLFLKYILAHFRGHPALSGSPDPQAVHSLEEPLPQTSSGSCHAP 240 Query: 241 KPACQLGSLDSLSAEVGVRSRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTR 300 KPACQLGSLDSLSAEVGVRSRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTR Sbjct: 241 KPACQLGSLDSLSAEVGVRSRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTR 300 Query: 301 SLPKASKSEERPSSPDTSTPGSRRLSPPPSPLPPPPPPSAHRKLSNPRGGEGSESQPCEV 360 SLPKASKSEERPSSPDTSTPGSRRLSPPPSPLPPPPPPSAHRKLSNPRGGEGSESQPCEV Sbjct: 301 SLPKASKSEERPSSPDTSTPGSRRLSPPPSPLPPPPPPSAHRKLSNPRGGEGSESQPCEV 360 Query: 361 LTPSPPGLGHHELIKLNWLLAKALWVLARRCYTLQAENKQLRRAGCPYQADEKVKRLKVK 420 LTPSPPGLGHHELIKLNWLLAKALWVLARRCYTLQ ENKQLRRAGCPYQADEKVKRLKVK Sbjct: 361 LTPSPPGLGHHELIKLNWLLAKALWVLARRCYTLQEENKQLRRAGCPYQADEKVKRLKVK 420 Query: 421 RAELTGLARRLADRARKLQETNLRAVSAPIPGESCAGLELCQVFARQRARDLSEQASAPL 480 RAELTGLARRLADRAR+LQETNLRAVSAPIPGESCAGLELCQVFARQRARDLSEQASAPL Sbjct: 421 RAELTGLARRLADRARELQETNLRAVSAPIPGESCAGLELCQVFARQRARDLSEQASAPL 480 Query: 481 AKDKQIEELRQECHLLQARVASGPCSDLHTGRGGPCTQWLNVRDLDRLQRESQREVLRLQ 540 AKDKQIEELRQECHLLQARVASGPCSDLHTGRGGPCTQWLNVRDLDRLQRESQREVLRLQ Sbjct: 481 AKDKQIEELRQECHLLQARVASGPCSDLHTGRGGPCTQWLNVRDLDRLQRESQREVLRLQ 540 Query: 541 RQLMLQQGNGGAWPEAGGQSATCEEVRRQMLALERELDQRRRECQELGAQAAPARRRGEE 600 RQLMLQQGNGGAWPEAGGQSATCEEVRRQMLALERELDQRRRECQELG QAAPARRRGEE Sbjct: 541 RQLMLQQGNGGAWPEAGGQSATCEEVRRQMLALERELDQRRRECQELGTQAAPARRRGEE 600 Query: 601 AETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLGRACQERDASGLIAEQL 660 AETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLGRACQERDASGLIAEQL Sbjct: 601 AETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLGRACQERDASGLIAEQL 660 Query: 661 LQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQVKGS 720 LQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQVKGS Sbjct: 661 LQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQVKGS 720 Query: 721 RRPKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQVSETVPASQPLSKKTS 780 RRPKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQVSETVPASQPLSKKTS Sbjct: 721 RRPKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQVSETVPASQPLSKKTS 780 Query: 781 SQSNSSSEGSMWATVPSSPTLDRDTASEVDDLEPDSVSLALEMGGSAAPAAPKLKIFMAQ 840 SQSNSSSEGSMWATVPSSPTLDRDTASEVDDLEPDSVSLALEMGGSAAPAAPKLKIFMAQ Sbjct: 781 SQSNSSSEGSMWATVPSSPTLDRDTASEVDDLEPDSVSLALEMGGSAAPAAPKLKIFMAQ 840 Query: 841 YNYNPFEGPNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELEDGRRGLVPSNFVEQIPDS 900 YNYNPFEGPNDHPEGELPLTAGDYIYIFGDMDEDGFYEGEL+DGRRGLVPSNFVEQIPDS Sbjct: 841 YNYNPFEGPNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELDDGRRGLVPSNFVEQIPDS 900 Query: 901 YIPGCLPAKSPDLGPSQLPAGQDEALEEDSLLSGKAQGVVDRGLCQMVRVGSKTEVATEI 960 YIPGCLPAKSPDLGPSQLPAGQDEALEEDSLLSGKAQG+VDRGLCQMVRVGSKTEVATEI Sbjct: 901 YIPGCLPAKSPDLGPSQLPAGQDEALEEDSLLSGKAQGMVDRGLCQMVRVGSKTEVATEI 960 Query: 961 LDTKTEACQLGLLQSMGKQGLSRPLLGTKGVLRMAPMQLHLQNVTATSANITWVYSSHRH 1020 LDTKTEACQLGLLQSMGKQGLSRPLLGTKGVLRMAPMQLHLQNVTATSANITWVYSSHRH Sbjct: 961 LDTKTEACQLGLLQSMGKQGLSRPLLGTKGVLRMAPMQLHLQNVTATSANITWVYSSHRH 1020 Query: 1021 PHVVYLDDREHALTPAGVSCYTFQGLCPGTHYRARVEVRLPRDLLQVYWGTMSSTVTFDT 1080 PHVVYLDDREHALTPAGVSCYTFQGLCPGTHYR RVEVRLP DLLQVYWGTMSSTVTFDT Sbjct: 1021 PHVVYLDDREHALTPAGVSCYTFQGLCPGTHYRVRVEVRLPWDLLQVYWGTMSSTVTFDT 1080 Query: 1081 LLAGPPYPPLDVLVERHASPGVLVVSWLPVTIDSAGSSNGVQVTGYAVYADGLKVCEVAD 1140 LLAGPPYPPLDVLVERHASPGVLVVSWLPVTIDSAGSSNGVQVTGYAVYADGLKVCEVAD Sbjct: 1081 LLAGPPYPPLDVLVERHASPGVLVVSWLPVTIDSAGSSNGVQVTGYAVYADGLKVCEVAD 1140 Query: 1141 ATAGSTLLEFSQLQVPLTWQKVSVRTMSLCGESLDSVPAQIPEDFFMCHRWPETPPFSYT 1200 ATAGST+LEFSQLQVPLTWQKVSVRTMSLCGESLDSVPAQIPEDFFMCHRWPETPPFSYT Sbjct: 1141 ATAGSTVLEFSQLQVPLTWQKVSVRTMSLCGESLDSVPAQIPEDFFMCHRWPETPPFSYT 1200 Query: 1201 CGDPSTYRVTFPVCPQKLSLAPPSAKASPHNPGSCGEPQAKFLEAFFEEPPRRQSPVSNL 1260 CGDPSTYRVTFPVCPQKLSLAPPSAKASPHNPGSCGEPQAKFLEAFFEEPPRRQSPVSNL Sbjct: 1201 CGDPSTYRVTFPVCPQKLSLAPPSAKASPHNPGSCGEPQAKFLEAFFEEPPRRQSPVSNL 1260 Query: 1261 GSEGECPSSGAGSQAQELAEAWEGCRKDLLFQKSPQNHRPPSVSDQPGEKENCSQHMGTS 1320 GSEGECPSSGAGSQAQELAEAWEGCRKDLLFQKSPQNHRPPSVSDQPGEKENC QHMGTS Sbjct: 1261 GSEGECPSSGAGSQAQELAEAWEGCRKDLLFQKSPQNHRPPSVSDQPGEKENCYQHMGTS 1320 Query: 1321 KSPAPGFIHLRTECGPRKEPCQEKAALERVLRQKQDAQGFTPPQLGASQQYASDFHNVLK 1380 KSPAPGFIHLRTECGPRKEPCQEKAALERVLRQKQDAQGFTPPQLGASQQYASDFHNVLK Sbjct: 1321 KSPAPGFIHLRTECGPRKEPCQEKAALERVLRQKQDAQGFTPPQLGASQQYASDFHNVLK 1380 Query: 1381 EEQEALCLDLWGTERREERREPEPHSRQGQALGVKRGCQLHEPSSALCPAPSAKVIKMPR 1440 EEQEALCLDL GTERREERREPEPHSRQGQALGVKRGCQLHEPSSALCPAPSAKVIKMPR Sbjct: 1381 EEQEALCLDLRGTERREERREPEPHSRQGQALGVKRGCQLHEPSSALCPAPSAKVIKMPR 1440 Query: 1441 GGPQQLGTGANTPARVFVALSDYNPLVMSANLKAAEEELVFQKRQLLRVWGSQDTHDFYL 1500 GGPQQLGTGANTPARVFVALSDYNPLVMSANLKAAEEELVFQKRQLLRVWGSQDTHDFYL Sbjct: 1441 GGPQQLGTGANTPARVFVALSDYNPLVMSANLKAAEEELVFQKRQLLRVWGSQDTHDFYL 1500 Query: 1501 SECNRQVGNIPGRLVAEMEVGTEQTDRRWRSPAQGNLPSVAHLEDFQGLTIPQGSSLVLQ 1560 SECNRQVGNIPGRLVAEMEVGTEQTDRRWRSPAQG+LPSVAHLEDFQGL IPQGSSLVLQ Sbjct: 1501 SECNRQVGNIPGRLVAEMEVGTEQTDRRWRSPAQGHLPSVAHLEDFQGLIIPQGSSLVLQ 1560 Query: 1561 GNSKRLPLWTPKIMIAALDYDPGDGQMGGQGKGRLALRAGDVVMVYGPMDDQGFYYGELG 1620 GNSKRLPLWTPKIMIAALDYDPGDGQMGGQGKGRLALRAGDVVMVYGPMDDQGFYYGELG Sbjct: 1561 GNSKRLPLWTPKIMIAALDYDPGDGQMGGQGKGRLALRAGDVVMVYGPMDDQGFYYGELG 1620 Query: 1621 GHRGLVPAHLLDHMSLHGH 1639 GHRGLVPAHLLDHMSLHGH Sbjct: 1621 GHRGLVPAHLLDHMSLHGH 1639 >gi|171906559 peripheral benzodiazepine receptor-associated protein 1 isoform a [Homo sapiens] Length = 1857 Score = 369 bits (946), Expect = e-101 Identities = 377/1203 (31%), Positives = 531/1203 (44%), Gaps = 219/1203 (18%) Query: 377 NWLLAKALWVLARRCYTLQAENKQLRRAGCPYQADEKVKRLKVKRAELTGLARRLADRAR 436 N L +AL L +RC L+ EN+ LR++ P + +EKV+RLK K AEL +A+RL +RAR Sbjct: 123 NLELLRALGELRQRCAILKEENQMLRKSSFP-ETEEKVRRLKRKNAELAVIAKRLEERAR 181 Query: 437 KLQETNLRAVSAPIPGESCAGLELCQ-VFARQRARDLSEQASAPLAKDKQIEELRQECHL 495 KLQETNLR VSAP+P + LELC+ ARQRARDLSE ASA LAKDKQI L++EC Sbjct: 182 KLQETNLRVVSAPLPRPGTS-LELCRKALARQRARDLSETASALLAKDKQIAALQRECRE 240 Query: 496 LQARVASGPCSDLHTGRGGPCTQWLNVRDLDRLQRESQREVLRLQRQLMLQ--------- 546 LQAR+ G+ GP QWL+VRD DRL RESQREVLRLQRQ+ L+ Sbjct: 241 LQARLTL-------VGKEGP--QWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLP 291 Query: 547 ---------QGNGGA-WPEAGGQSATCE------------EVRRQMLALERELDQRRREC 584 Q GA P A G++ E E +++ LE EL ++R++C Sbjct: 292 PSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKC 351 Query: 585 QELGAQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLG 644 + L +A +RR EE E QL+ A +NA L EEN RL + +VE EN+E+RG L Sbjct: 352 ESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLL 411 Query: 645 RACQERDAS-----GLIA-----EQLLQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQA 694 QERD++ GL + EQ+L+ R+QQL+ + ++A L +E++ Sbjct: 412 GVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRR 471 Query: 695 LQCRPGHPPEQPWETSQMPESQVKGS----RRPKFHARPEDYAVSQPNRDIQEKREASLE 750 LQ + Q+ ES + R + R + S +++Q R L Sbjct: 472 LQQAQAEAQREHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFR---LH 528 Query: 751 ESPVALGESA----------------SVPQV-----------------------SETVPA 771 P+ L SA S+PQ SE PA Sbjct: 529 PGPLDLLTSALDCGSLGDCPPPPCCCSIPQPCRGSGPKDLDLPPGSPGRCTPKSSEPAPA 588 Query: 772 S-----QPLSKKTSSQSNSSSEGSMWATVPSSPTLDRDTASEVDDLEPDSVSLALEMGGS 826 + + +KK S SNSS S+ + S PT + DTASEV++LE DSVSL L Sbjct: 589 TLTGVPRRTAKKAESLSNSSHSESIHNSPKSCPTPEVDTASEVEELEADSVSL-LPAAPE 647 Query: 827 AAPAAPKLKIFMAQYNYNPFEGPNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELEDGRR 886 + ++++F+A+Y+YNPFEGPN++PE ELPLTAG+YIYI+G+MDEDGF+EGEL DGRR Sbjct: 648 GSRGGARIQVFLARYSYNPFEGPNENPEAELPLTAGEYIYIYGNMDEDGFFEGELMDGRR 707 Query: 887 GLVPSNFVEQIPDSYIPGCLPAKSPDL---------------------GPSQLPAGQDEA 925 GLVPSNFVE++ D + LP + DL G S + Q Sbjct: 708 GLVPSNFVERVSDDDLLTSLPPELADLSHSSGPELSFLSVGGGGSSSGGQSSVGRSQPRP 767 Query: 926 LEEDS----LLSGKAQGVVD-------RGLCQMVRVGSKTEVATEILDTKTE-----ACQ 969 EED+ LS +G+ + R L + ++ +A E + E C Sbjct: 768 EEEDAGDELSLSPSPEGLGEPPAVPYPRRLVVLKQLAHSVVLAWEPPPEQVELHGFHICV 827 Query: 970 LG-LLQSMGKQGLSRPLLGTKGVLRMAPMQLHLQNVTA--TSANITWVYSSHRHPHVVYL 1026 G L Q++G + +L L P+ + +Q +T+ +S + + VV Sbjct: 828 NGELRQALGPGAPPKAVLENLD-LWAGPLHISVQALTSRGSSDPLRCCLAVGARAGVVPS 886 Query: 1027 DDREHALTPAGVSCYTFQGLCPGTHYRARVEVRLPRDLLQVYWGTM---------SSTVT 1077 R H LT G H P YW T + V Sbjct: 887 QLRVHRLTATSAEITWVPGNSNLAHAIYLNGEECPPASPSTYWATFCHLRPGTPYQAQVE 946 Query: 1078 FDTLLAGPPYPPLDVLVERHASPGVLVVSWLPVTIDSA--------GSSNGVQVTGY--- 1126 GP P + L +R A+ L + LP A G S G+ + + Sbjct: 947 AQLPPQGPWEPGWERLEQRAAT---LQFTTLPAGPPDAPLDVQIEPGPSPGILIISWLPV 1003 Query: 1127 ----AVYADGLKVCEVADATAGSTLLE------------FSQLQVPLTWQKVSVRTMSLC 1170 A ++G++V A G ++E SQLQ+ ++V VRTMS Sbjct: 1004 TIDAAGTSNGVRVTGYAIYADGQKIMEVASPTAGSVLVELSQLQLLQVCREVVVRTMSPH 1063 Query: 1171 GESLDSVPAQIPEDFFMCHRWPETPPFSYTCGDPSTYRVTFPVCPQKLSLAPPSAKASPH 1230 GES DS+PA I P P S RV+ P P A ASP Sbjct: 1064 GESADSIPAPIT---------PALAPASLPA------RVSCPSPHPSPEARAPLASASP- 1107 Query: 1231 NPGSCGEPQAKFLEAFFEEPPRR--QSPVSNLGSEGECPSSGAGSQAQELAEAWEGCRKD 1288 PG P +EPP SP + ++G A +E A G ++ Sbjct: 1108 GPGDPSSPLQHPAPLGTQEPPGAPPASPSREM-AKGSHEDPPAPCSQEEAGAAVLGTSEE 1166 Query: 1289 LLFQKSPQNHRPPSVSDQPGEKENCSQHMGTSKSPAPGFIHLRTECGPRKEPCQ--EKAA 1346 S + P + K+ G + + R + P E CQ + + Sbjct: 1167 RTASTSTLGEKDPGPAAPSLAKQEAEWTAGEACPASSSTQGARAQQAPNTEMCQGGDPGS 1226 Query: 1347 LERVLRQKQDAQGFTPPQLGASQQYA--SDFHNVLKEEQEALCLDLWGTERREERREPEP 1404 R +K+D + + + SD ++ +EE+E EE E E Sbjct: 1227 GLRPRAEKEDTAELGVHLVNSLVDHGRNSDLSDIQEEEEE-----------EEEEEEEEL 1275 Query: 1405 HSR 1407 SR Sbjct: 1276 GSR 1278 Score = 128 bits (322), Expect = 4e-29 Identities = 95/261 (36%), Positives = 127/261 (48%), Gaps = 33/261 (12%) Query: 1395 RREERREPEPHSRQGQALGVKRGCQLHEPSSA-LCPAPSAKVIKMPRGGPQQLGTGANTP 1453 R E E G+ KRG ++ PS+A L PA S P + + P Sbjct: 1577 RATETGEARGQDGSGRRGPQKRGVRVLRPSTAELVPARS----------PSETLAYQHLP 1626 Query: 1454 ARVFVALSDYNPLVMSANLKAAEEELVFQKRQLLRVWGSQDTHDFYLSECNRQVGNIPGR 1513 R+FVAL DY+P+ MS N A EEEL F++ Q+L+V+G +D FY E + G IP Sbjct: 1627 VRIFVALFDYDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGEGGGRTGYIPCN 1686 Query: 1514 LVAEMEV----GTEQT-DRRWRSP-----AQGNLPSVAHLEDFQG---------LTIPQG 1554 +VAE+ V G +Q R + SP GN P V G +G Sbjct: 1687 MVAEVAVDSPAGRQQLLQRGYLSPDILLEGSGNGPFVYSTAHTTGPPPKPRRSKKAESEG 1746 Query: 1555 SSLVLQGNSKRLP---LWTPKIMIAALDYDPGDGQMGGQGKGRLALRAGDVVMVYGPMDD 1611 + G K +P L P M+AA DY+P + + L RAGDV+ V+G MDD Sbjct: 1747 PAQPCPGPPKLVPSADLKAPHSMVAAFDYNPQESSPNMDVEAELPFRAGDVITVFGGMDD 1806 Query: 1612 QGFYYGELGGHRGLVPAHLLD 1632 GFYYGEL G RGLVP++ L+ Sbjct: 1807 DGFYYGELNGQRGLVPSNFLE 1827 Score = 70.5 bits (171), Expect = 1e-11 Identities = 36/59 (61%), Positives = 44/59 (74%), Gaps = 2/59 (3%) Query: 838 MAQYNYNPFEG-PNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELEDGRRGLVPSNFVE 895 +A ++YNP E PN E ELP AGD I +FG MD+DGFY GEL +G+RGLVPSNF+E Sbjct: 1770 VAAFDYNPQESSPNMDVEAELPFRAGDVITVFGGMDDDGFYYGEL-NGQRGLVPSNFLE 1827 Score = 57.8 bits (138), Expect = 9e-08 Identities = 65/219 (29%), Positives = 90/219 (41%), Gaps = 41/219 (18%) Query: 723 PKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQVSETVPASQPLSKKTSSQ 782 PK ++ P+ Y P EK E P G SA T A +PLS+ T + Sbjct: 1540 PKANSGPKPY----PRLPAWEKGE------PERRGRSA-------TGRAKEPLSRATETG 1582 Query: 783 SNSSSEGS-MWATVPSSPTLDRDTASEVDDLEPDSVSLALEMGGSAAPAAPKLKIFMAQY 841 +GS + R + +E+ S +LA + ++IF+A + Sbjct: 1583 EARGQDGSGRRGPQKRGVRVLRPSTAELVPARSPSETLAYQH--------LPVRIFVALF 1634 Query: 842 NYNPFE-GPN-DHPEGELPLTAGDYIYIFGDMDEDGFYEGELEDGRRGLVPSNFVEQIPD 899 +Y+P PN D E ELP G + +FGD D DGFY+GE GR G +P N V ++ Sbjct: 1635 DYDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGE-GGGRTGYIPCNMVAEV-- 1691 Query: 900 SYIPGCLPAKSPDLGPSQLPAGQDEALEEDSLLSGKAQG 938 A G QL Q L D LL G G Sbjct: 1692 --------AVDSPAGRQQLL--QRGYLSPDILLEGSGNG 1720 Score = 48.9 bits (115), Expect = 4e-05 Identities = 24/65 (36%), Positives = 40/65 (61%), Gaps = 2/65 (3%) Query: 1572 KIMIAALDYDPGDGQMGGQGKGRLALRAGDVVMVYGPMDDQGFYYGEL-GGHRGLVPAHL 1630 ++ +A Y+P +G + L L AG+ + +YG MD+ GF+ GEL G RGLVP++ Sbjct: 656 QVFLARYSYNPFEGP-NENPEAELPLTAGEYIYIYGNMDEDGFFEGELMDGRRGLVPSNF 714 Query: 1631 LDHMS 1635 ++ +S Sbjct: 715 VERVS 719 Score = 48.1 bits (113), Expect = 7e-05 Identities = 86/370 (23%), Positives = 141/370 (38%), Gaps = 63/370 (17%) Query: 6 PSP-LGASPKKPGCSSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAARER--QLR 62 P P L A P +P A + L + E E E+ + E R++ L Sbjct: 296 PGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLE 355 Query: 63 EEAERERRQLADRLRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLH 122 +EA +++R+ + L + ++ R ++E + A ++ + W+ AE R + Sbjct: 356 QEARKKQRR-CEELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVT 414 Query: 123 RERDGVVRQARELQRQL--AEELVN--RGHCSRPGASEVSAAQCRC----------RLQE 168 +ERD +R+++ LQ +L E+++ R R EV Q R RLQ+ Sbjct: 415 QERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQ 474 Query: 169 VLAQLRWQTDG----------EQAARIRYL--QAALEVERQLFLKYILAHFRGHP----- 211 A+ + + +G AR+R L Q + E+ L L FR HP Sbjct: 475 AQAEAQREHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFRLHPGPLDL 534 Query: 212 --------ALSGSPDPQAVHSLEEP----------LPQTSSGSCHAPKPACQLGSLDSLS 253 +L P P S+ +P LP S G C PK S + + Sbjct: 535 LTSALDCGSLGDCPPPPCCCSIPQPCRGSGPKDLDLPPGSPGRC-TPK-----SSEPAPA 588 Query: 254 AEVGVRSRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTRSLPKASKSEERPS 313 GV R+ S +SS S H S C P + + +A P+ Sbjct: 589 TLTGVPRRTAKKAESLSNSSHSE--SIHNSPKSCPTPEVDTASEVEEL--EADSVSLLPA 644 Query: 314 SPDTSTPGSR 323 +P+ S G+R Sbjct: 645 APEGSRGGAR 654 Score = 46.2 bits (108), Expect = 3e-04 Identities = 22/66 (33%), Positives = 35/66 (53%), Gaps = 1/66 (1%) Query: 1572 KIMIAALDYDPGDGQMGGQ-GKGRLALRAGDVVMVYGPMDDQGFYYGELGGHRGLVPAHL 1630 +I +A DYDP G+ L R G ++ V+G D GFY GE GG G +P ++ Sbjct: 1628 RIFVALFDYDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGEGGGRTGYIPCNM 1687 Query: 1631 LDHMSL 1636 + +++ Sbjct: 1688 VAEVAV 1693 Score = 34.7 bits (78), Expect = 0.78 Identities = 59/258 (22%), Positives = 99/258 (38%), Gaps = 35/258 (13%) Query: 331 PLPP--PPPPSAHRKLSNPRGGEGSESQPCEVLTPSPPGLGHHELIKLNWLLAKALWVLA 388 PLPP PP P+ + P G E+ P E P LG E + L L Sbjct: 289 PLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKR 348 Query: 389 RRCYTLQAENKQLRRAGCPYQADEKVKRLKVKRAELTGLARRLADRARKLQETNLRAVSA 448 ++C +L+ E ++ +R C + + ++++ + + A L RL+ RA + ++ +A Sbjct: 349 KKCESLEQEARKKQRR-CE-ELELQLRQAQNENARLVEENSRLSGRATEKEQVEWE--NA 404 Query: 449 PIPGESCAGLELCQVFARQRARDLSEQASAPLAKDKQIEELRQECHLLQARVASGPCSDL 508 + G+ G+ + A ++++ L + + K + E+ Q L+ S Sbjct: 405 ELRGQ-LLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLS-- 461 Query: 509 HTGRGGPCTQWLNVRDLDRLQRESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRR 568 RE Q EV R LQQ A E G E Sbjct: 462 --------------------LREKQEEVRR------LQQAQAEAQREHEGAVQLLESTLD 495 Query: 569 QMLALERELDQRRRECQE 586 M A REL+++ R E Sbjct: 496 SMQARVRELEEQCRSQTE 513 >gi|171906567 peripheral benzodiazepine receptor-associated protein 1 isoform b [Homo sapiens] Length = 1797 Score = 268 bits (686), Expect = 2e-71 Identities = 337/1202 (28%), Positives = 485/1202 (40%), Gaps = 277/1202 (23%) Query: 377 NWLLAKALWVLARRCYTLQAENKQLRRAGCPYQADEKVKRLKVKRAELTGLARRLADRAR 436 N L +AL L +RC L+ EN+ LR++ P + +EKV+RLK K AEL +A + Sbjct: 123 NLELLRALGELRQRCAILKEENQMLRKSSFP-ETEEKVRRLKRKNAELAVIA-------K 174 Query: 437 KLQETNLRAVSAPIPGESCAGLELCQVFARQRARDLSEQASAPLAKDKQIEELRQECHLL 496 +L+E RAR L E LR E Sbjct: 175 RLEE---------------------------RARKLQET------------NLRVE---- 191 Query: 497 QARVASGPCSDLHTGRGGPCTQWLNVRDLDRLQRESQREVLRLQRQLMLQ---------- 546 GP QWL+VRD DRL RESQREVLRLQRQ+ L+ Sbjct: 192 -----------------GP--QWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPP 232 Query: 547 --------QGNGGA-WPEAGGQSATCE------------EVRRQMLALERELDQRRRECQ 585 Q GA P A G++ E E +++ LE EL ++R++C+ Sbjct: 233 SWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCE 292 Query: 586 ELGAQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLGR 645 L +A +RR EE E QL+ A +NA L EEN RL + +VE EN+E+RG L Sbjct: 293 SLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLG 352 Query: 646 ACQERDAS-----GLIA-----EQLLQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQAL 695 QERD++ GL + EQ+L+ R+QQL+ + ++A L +E++ L Sbjct: 353 VTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRL 412 Query: 696 QCRPGHPPEQPWETSQMPESQVKGS----RRPKFHARPEDYAVSQPNRDIQEKREASLEE 751 Q + Q+ ES + R + R + S +++Q R L Sbjct: 413 QQAQAEAQREHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFR---LHP 469 Query: 752 SPVALGESA----------------SVPQV-----------------------SETVPAS 772 P+ L SA S+PQ SE PA+ Sbjct: 470 GPLDLLTSALDCGSLGDCPPPPCCCSIPQPCRGSGPKDLDLPPGSPGRCTPKSSEPAPAT 529 Query: 773 -----QPLSKKTSSQSNSSSEGSMWATVPSSPTLDRDTASEVDDLEPDSVSLALEMGGSA 827 + +KK S SNSS S+ + S PT + DTASEV++LE DSVSL L Sbjct: 530 LTGVPRRTAKKAESLSNSSHSESIHNSPKSCPTPEVDTASEVEELEADSVSL-LPAAPEG 588 Query: 828 APAAPKLKIFMAQYNYNPFEGPNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELEDGRRG 887 + ++++F+A+Y+YNPFEGPN++PE ELPLTAG+YIYI+G+MDEDGF+EGEL DGRRG Sbjct: 589 SRGGARIQVFLARYSYNPFEGPNENPEAELPLTAGEYIYIYGNMDEDGFFEGELMDGRRG 648 Query: 888 LVPSNFVEQIPDSYIPGCLPAKSPDL---------------------GPSQLPAGQDEAL 926 LVPSNFVE++ D + LP + DL G S + Q Sbjct: 649 LVPSNFVERVSDDDLLTSLPPELADLSHSSGPELSFLSVGGGGSSSGGQSSVGRSQPRPE 708 Query: 927 EEDS----LLSGKAQGVVD-------RGLCQMVRVGSKTEVATEILDTKTE-----ACQL 970 EED+ LS +G+ + R L + ++ +A E + E C Sbjct: 709 EEDAGDELSLSPSPEGLGEPPAVPYPRRLVVLKQLAHSVVLAWEPPPEQVELHGFHICVN 768 Query: 971 G-LLQSMGKQGLSRPLLGTKGVLRMAPMQLHLQNVTA--TSANITWVYSSHRHPHVVYLD 1027 G L Q++G + +L L P+ + +Q +T+ +S + + VV Sbjct: 769 GELRQALGPGAPPKAVLENLD-LWAGPLHISVQALTSRGSSDPLRCCLAVGARAGVVPSQ 827 Query: 1028 DREHALTPAGVSCYTFQGLCPGTHYRARVEVRLPRDLLQVYWGTM---------SSTVTF 1078 R H LT G H P YW T + V Sbjct: 828 LRVHRLTATSAEITWVPGNSNLAHAIYLNGEECPPASPSTYWATFCHLRPGTPYQAQVEA 887 Query: 1079 DTLLAGPPYPPLDVLVERHASPGVLVVSWLPVTIDSA--------GSSNGVQVTGY---- 1126 GP P + L +R A+ L + LP A G S G+ + + Sbjct: 888 QLPPQGPWEPGWERLEQRAAT---LQFTTLPAGPPDAPLDVQIEPGPSPGILIISWLPVT 944 Query: 1127 ---AVYADGLKVCEVADATAGSTLLE------------FSQLQVPLTWQKVSVRTMSLCG 1171 A ++G++V A G ++E SQLQ+ ++V VRTMS G Sbjct: 945 IDAAGTSNGVRVTGYAIYADGQKIMEVASPTAGSVLVELSQLQLLQVCREVVVRTMSPHG 1004 Query: 1172 ESLDSVPAQIPEDFFMCHRWPETPPFSYTCGDPSTYRVTFPVCPQKLSLAPPSAKASPHN 1231 ES DS+PA I P P S RV+ P P A ASP Sbjct: 1005 ESADSIPAPIT---------PALAPASLPA------RVSCPSPHPSPEARAPLASASP-G 1048 Query: 1232 PGSCGEPQAKFLEAFFEEPPRR--QSPVSNLGSEGECPSSGAGSQAQELAEAWEGCRKDL 1289 PG P +EPP SP + ++G A +E A G ++ Sbjct: 1049 PGDPSSPLQHPAPLGTQEPPGAPPASPSREM-AKGSHEDPPAPCSQEEAGAAVLGTSEER 1107 Query: 1290 LFQKSPQNHRPPSVSDQPGEKENCSQHMGTSKSPAPGFIHLRTECGPRKEPCQ--EKAAL 1347 S + P + K+ G + + R + P E CQ + + Sbjct: 1108 TASTSTLGEKDPGPAAPSLAKQEAEWTAGEACPASSSTQGARAQQAPNTEMCQGGDPGSG 1167 Query: 1348 ERVLRQKQDAQGFTPPQLGASQQYA--SDFHNVLKEEQEALCLDLWGTERREERREPEPH 1405 R +K+D + + + SD ++ +EE+E EE E E Sbjct: 1168 LRPRAEKEDTAELGVHLVNSLVDHGRNSDLSDIQEEEEE-----------EEEEEEEELG 1216 Query: 1406 SR 1407 SR Sbjct: 1217 SR 1218 Score = 128 bits (322), Expect = 4e-29 Identities = 95/261 (36%), Positives = 127/261 (48%), Gaps = 33/261 (12%) Query: 1395 RREERREPEPHSRQGQALGVKRGCQLHEPSSA-LCPAPSAKVIKMPRGGPQQLGTGANTP 1453 R E E G+ KRG ++ PS+A L PA S P + + P Sbjct: 1517 RATETGEARGQDGSGRRGPQKRGVRVLRPSTAELVPARS----------PSETLAYQHLP 1566 Query: 1454 ARVFVALSDYNPLVMSANLKAAEEELVFQKRQLLRVWGSQDTHDFYLSECNRQVGNIPGR 1513 R+FVAL DY+P+ MS N A EEEL F++ Q+L+V+G +D FY E + G IP Sbjct: 1567 VRIFVALFDYDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGEGGGRTGYIPCN 1626 Query: 1514 LVAEMEV----GTEQT-DRRWRSP-----AQGNLPSVAHLEDFQG---------LTIPQG 1554 +VAE+ V G +Q R + SP GN P V G +G Sbjct: 1627 MVAEVAVDSPAGRQQLLQRGYLSPDILLEGSGNGPFVYSTAHTTGPPPKPRRSKKAESEG 1686 Query: 1555 SSLVLQGNSKRLP---LWTPKIMIAALDYDPGDGQMGGQGKGRLALRAGDVVMVYGPMDD 1611 + G K +P L P M+AA DY+P + + L RAGDV+ V+G MDD Sbjct: 1687 PAQPCPGPPKLVPSADLKAPHSMVAAFDYNPQESSPNMDVEAELPFRAGDVITVFGGMDD 1746 Query: 1612 QGFYYGELGGHRGLVPAHLLD 1632 GFYYGEL G RGLVP++ L+ Sbjct: 1747 DGFYYGELNGQRGLVPSNFLE 1767 Score = 70.5 bits (171), Expect = 1e-11 Identities = 36/59 (61%), Positives = 44/59 (74%), Gaps = 2/59 (3%) Query: 838 MAQYNYNPFEG-PNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELEDGRRGLVPSNFVE 895 +A ++YNP E PN E ELP AGD I +FG MD+DGFY GEL +G+RGLVPSNF+E Sbjct: 1710 VAAFDYNPQESSPNMDVEAELPFRAGDVITVFGGMDDDGFYYGEL-NGQRGLVPSNFLE 1767 Score = 57.8 bits (138), Expect = 9e-08 Identities = 65/219 (29%), Positives = 90/219 (41%), Gaps = 41/219 (18%) Query: 723 PKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQVSETVPASQPLSKKTSSQ 782 PK ++ P+ Y P EK E P G SA T A +PLS+ T + Sbjct: 1480 PKANSGPKPY----PRLPAWEKGE------PERRGRSA-------TGRAKEPLSRATETG 1522 Query: 783 SNSSSEGS-MWATVPSSPTLDRDTASEVDDLEPDSVSLALEMGGSAAPAAPKLKIFMAQY 841 +GS + R + +E+ S +LA + ++IF+A + Sbjct: 1523 EARGQDGSGRRGPQKRGVRVLRPSTAELVPARSPSETLAYQH--------LPVRIFVALF 1574 Query: 842 NYNPFE-GPN-DHPEGELPLTAGDYIYIFGDMDEDGFYEGELEDGRRGLVPSNFVEQIPD 899 +Y+P PN D E ELP G + +FGD D DGFY+GE GR G +P N V ++ Sbjct: 1575 DYDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGE-GGGRTGYIPCNMVAEV-- 1631 Query: 900 SYIPGCLPAKSPDLGPSQLPAGQDEALEEDSLLSGKAQG 938 A G QL Q L D LL G G Sbjct: 1632 --------AVDSPAGRQQLL--QRGYLSPDILLEGSGNG 1660 Score = 48.9 bits (115), Expect = 4e-05 Identities = 24/65 (36%), Positives = 40/65 (61%), Gaps = 2/65 (3%) Query: 1572 KIMIAALDYDPGDGQMGGQGKGRLALRAGDVVMVYGPMDDQGFYYGEL-GGHRGLVPAHL 1630 ++ +A Y+P +G + L L AG+ + +YG MD+ GF+ GEL G RGLVP++ Sbjct: 596 QVFLARYSYNPFEGP-NENPEAELPLTAGEYIYIYGNMDEDGFFEGELMDGRRGLVPSNF 654 Query: 1631 LDHMS 1635 ++ +S Sbjct: 655 VERVS 659 Score = 48.1 bits (113), Expect = 7e-05 Identities = 86/370 (23%), Positives = 141/370 (38%), Gaps = 63/370 (17%) Query: 6 PSP-LGASPKKPGCSSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAARER--QLR 62 P P L A P +P A + L + E E E+ + E R++ L Sbjct: 236 PGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLE 295 Query: 63 EEAERERRQLADRLRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLH 122 +EA +++R+ + L + ++ R ++E + A ++ + W+ AE R + Sbjct: 296 QEARKKQRR-CEELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVT 354 Query: 123 RERDGVVRQARELQRQL--AEELVN--RGHCSRPGASEVSAAQCRC----------RLQE 168 +ERD +R+++ LQ +L E+++ R R EV Q R RLQ+ Sbjct: 355 QERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQ 414 Query: 169 VLAQLRWQTDG----------EQAARIRYL--QAALEVERQLFLKYILAHFRGHP----- 211 A+ + + +G AR+R L Q + E+ L L FR HP Sbjct: 415 AQAEAQREHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFRLHPGPLDL 474 Query: 212 --------ALSGSPDPQAVHSLEEP----------LPQTSSGSCHAPKPACQLGSLDSLS 253 +L P P S+ +P LP S G C PK S + + Sbjct: 475 LTSALDCGSLGDCPPPPCCCSIPQPCRGSGPKDLDLPPGSPGRC-TPK-----SSEPAPA 528 Query: 254 AEVGVRSRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTRSLPKASKSEERPS 313 GV R+ S +SS S H S C P + + +A P+ Sbjct: 529 TLTGVPRRTAKKAESLSNSSHSE--SIHNSPKSCPTPEVDTASEVEEL--EADSVSLLPA 584 Query: 314 SPDTSTPGSR 323 +P+ S G+R Sbjct: 585 APEGSRGGAR 594 Score = 46.2 bits (108), Expect = 3e-04 Identities = 22/66 (33%), Positives = 35/66 (53%), Gaps = 1/66 (1%) Query: 1572 KIMIAALDYDPGDGQMGGQ-GKGRLALRAGDVVMVYGPMDDQGFYYGELGGHRGLVPAHL 1630 +I +A DYDP G+ L R G ++ V+G D GFY GE GG G +P ++ Sbjct: 1568 RIFVALFDYDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGEGGGRTGYIPCNM 1627 Query: 1631 LDHMSL 1636 + +++ Sbjct: 1628 VAEVAV 1633 Score = 34.7 bits (78), Expect = 0.78 Identities = 59/258 (22%), Positives = 99/258 (38%), Gaps = 35/258 (13%) Query: 331 PLPP--PPPPSAHRKLSNPRGGEGSESQPCEVLTPSPPGLGHHELIKLNWLLAKALWVLA 388 PLPP PP P+ + P G E+ P E P LG E + L L Sbjct: 229 PLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKR 288 Query: 389 RRCYTLQAENKQLRRAGCPYQADEKVKRLKVKRAELTGLARRLADRARKLQETNLRAVSA 448 ++C +L+ E ++ +R C + + ++++ + + A L RL+ RA + ++ +A Sbjct: 289 KKCESLEQEARKKQRR-CE-ELELQLRQAQNENARLVEENSRLSGRATEKEQVEWE--NA 344 Query: 449 PIPGESCAGLELCQVFARQRARDLSEQASAPLAKDKQIEELRQECHLLQARVASGPCSDL 508 + G+ G+ + A ++++ L + + K + E+ Q L+ S Sbjct: 345 ELRGQ-LLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLS-- 401 Query: 509 HTGRGGPCTQWLNVRDLDRLQRESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRR 568 RE Q EV R LQQ A E G E Sbjct: 402 --------------------LREKQEEVRR------LQQAQAEAQREHEGAVQLLESTLD 435 Query: 569 QMLALERELDQRRRECQE 586 M A REL+++ R E Sbjct: 436 SMQARVRELEEQCRSQTE 453 >gi|140561070 RIM-binding protein 2 [Homo sapiens] Length = 1052 Score = 212 bits (539), Expect = 3e-54 Identities = 190/616 (30%), Positives = 278/616 (45%), Gaps = 119/616 (19%) Query: 669 DRQQQLQRDPQKALCDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQVKGSRRPKFHAR 728 +R+QQLQ + +AL L +EI LQ S++ E + K R Sbjct: 6 ERRQQLQLEHDQALAVLSAKQQEIDLLQ------------KSKVRELEEK--------CR 45 Query: 729 PEDYAVSQPNRDIQEKREASLEESPVALGESASVPQVSETVPASQPLSKKTSSQSNSSSE 788 + + +RD+++ R+ + + LG SA P T P S+P + + + S + Sbjct: 46 TQSEQFNLLSRDLEKFRQHAGKID--LLGGSAVAPLDISTAP-SKPFPQFMNGLATSLGK 102 Query: 789 GSMWATVPSSPTLD--RDTASEVDDLEPDSVSLA-LEMGGSAAPAAP------------- 832 G A SS + R D EP S L GSA + Sbjct: 103 GQESAIGGSSAIGEYIRPLPQPGDRPEPLSAKPTFLSRSGSARCRSESDMENERNSNTSK 162 Query: 833 -----KLKIFMAQYNYNPFEGPNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELEDGRRG 887 K+ + +A+Y+YNPF+GPN++PE ELPLTAG Y+Y++GDMDEDGFYEGEL DG+RG Sbjct: 163 QRYSGKVHLCVARYSYNPFDGPNENPEAELPLTAGKYLYVYGDMDEDGFYEGELLDGQRG 222 Query: 888 LVPSNFV--------------------------------EQIPDSYIPGCLPAKSPDLGP 915 LVPSNFV E I D + P + A D Sbjct: 223 LVPSNFVDFVQDNESRLASTLGNEQDQNFINHSGIGLEGEHILDLHSPTHIDAGITDNSA 282 Query: 916 SQLPAGQDEALEED-------SLLSGKAQGV----------------------VDRGLCQ 946 L D+ E+ +L+ A+ V VD+ Sbjct: 283 GTLDVNIDDIGEDIVPYPRKITLIKQLAKSVIVGWEPPAVPPGWGTVSSYNVLVDKETRM 342 Query: 947 MVRVGSKTEVATEILDTKTEACQLGL-LQSMGKQGLSRPLLGTKGVLR---MAPMQLHLQ 1002 + +GS+T+ E L+ AC + +Q + +G S L T V + +AP L + Sbjct: 343 NLTLGSRTKALIEKLNMA--ACTYRISVQCVTSRGSSDELQCTLLVGKDVVVAPSHLRVD 400 Query: 1003 NVTATSANITWVYSSHRHPHVVYLDDREHALTPAGVSCYTFQGLCPGTHYRARVEVR--- 1059 N+T SA ++W+ ++ + HV++L++ E + A Y F L P Y+ +V + Sbjct: 401 NITQISAQLSWLPTNSNYSHVIFLNEEEFDIVKAARYKYQFFNLRPNMAYKVKVLAKPHQ 460 Query: 1060 LPRDLLQVYWGTMSSTVTFDTLLAGPPYPPLDVLVERHASPGVLVVSWLPVTIDSAGSSN 1119 +P L + V F TL AGPP PP DV V+ +P + VSW P + G SN Sbjct: 461 MPWQLPLEQREKKEAFVEFSTLPAGPPAPPQDVTVQAGVTPATIRVSWRPPVLTPTGLSN 520 Query: 1120 GVQVTGYAVYADGLKVCEVADATAGSTLLEFSQLQVPLTWQKVSVRTMSLCGESLDSVPA 1179 G VTGY VYA G +V EV TA ST +E +L+ L + V+VRT+S GES+DS A Sbjct: 521 GANVTGYGVYAKGQRVAEVIFPTADSTAVELVRLR-SLEAKGVTVRTLSAQGESVDSAVA 579 Query: 1180 QIPEDFFMCHRWPETP 1195 +P + + P TP Sbjct: 580 AVPPELLV----PPTP 591 Score = 116 bits (291), Expect = 2e-25 Identities = 68/183 (37%), Positives = 102/183 (55%), Gaps = 15/183 (8%) Query: 1453 PARVFVALSDYNPLVMSANLKAAEEELVFQKRQLLRVWGSQDTHDFYLSECNRQVGNIPG 1512 PAR+FVAL DY+PL MS N AAEEEL F++ Q+++V+G +D FY E ++G IP Sbjct: 849 PARIFVALFDYDPLTMSPNPDAAEEELPFKEGQIIKVYGDKDADGFYRGETCARLGLIPC 908 Query: 1513 RLVAEMEVGTEQ-TDRRWRSPAQGNLPSVAHLEDFQGLTIPQGSSLVLQGNSKRLPLWTP 1571 +V+E++ E+ D+ R QG LP +E + S R + Sbjct: 909 NMVSEIQADDEEMMDQLLR---QGFLPLNTPVEKIE-----------RSRRSGRRHSVST 954 Query: 1572 KIMIAALDYDPGDGQMGGQGKGRLALRAGDVVMVYGPMDDQGFYYGELGGHRGLVPAHLL 1631 + M+A DYDP + + L GD++ V+G +D+ GFYYGEL G +GLVP++ L Sbjct: 955 RRMVALYDYDPRESSPNVDVEAELTFCTGDIITVFGEIDEDGFYYGELNGQKGLVPSNFL 1014 Query: 1632 DHM 1634 + + Sbjct: 1015 EEV 1017 Score = 71.6 bits (174), Expect = 6e-12 Identities = 35/63 (55%), Positives = 47/63 (74%), Gaps = 2/63 (3%) Query: 838 MAQYNYNPFEG-PNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELEDGRRGLVPSNFVEQ 896 +A Y+Y+P E PN E EL GD I +FG++DEDGFY GEL +G++GLVPSNF+E+ Sbjct: 958 VALYDYDPRESSPNVDVEAELTFCTGDIITVFGEIDEDGFYYGEL-NGQKGLVPSNFLEE 1016 Query: 897 IPD 899 +PD Sbjct: 1017 VPD 1019 Score = 59.3 bits (142), Expect = 3e-08 Identities = 38/97 (39%), Positives = 50/97 (51%), Gaps = 5/97 (5%) Query: 805 TASEVDDLEPDSVSLALEMGGSAAPAAPKL--KIFMAQYNYNPFE-GPN-DHPEGELPLT 860 T +DD D +S P A +L +IF+A ++Y+P PN D E ELP Sbjct: 819 TVPSIDDYGRDRLSPDFYEESETDPGAEELPARIFVALFDYDPLTMSPNPDAAEEELPFK 878 Query: 861 AGDYIYIFGDMDEDGFYEGELEDGRRGLVPSNFVEQI 897 G I ++GD D DGFY GE R GL+P N V +I Sbjct: 879 EGQIIKVYGDKDADGFYRGE-TCARLGLIPCNMVSEI 914 Score = 49.7 bits (117), Expect = 2e-05 Identities = 27/61 (44%), Positives = 36/61 (59%), Gaps = 2/61 (3%) Query: 1573 IMIAALDYDPGDGQMGGQGKGRLALRAGDVVMVYGPMDDQGFYYGE-LGGHRGLVPAHLL 1631 + +A Y+P DG + L L AG + VYG MD+ GFY GE L G RGLVP++ + Sbjct: 171 LCVARYSYNPFDGP-NENPEAELPLTAGKYLYVYGDMDEDGFYEGELLDGQRGLVPSNFV 229 Query: 1632 D 1632 D Sbjct: 230 D 230 >gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4 isoform 2 [Homo sapiens] Length = 1320 Score = 79.0 bits (193), Expect = 4e-14 Identities = 92/327 (28%), Positives = 144/327 (44%), Gaps = 35/327 (10%) Query: 30 RRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSRELR 89 RR+ +L+ E ER+ A RR+ +E+QLRE+ E +R+ LA+ R K Q+ + R Sbjct: 353 RRDFLRLQQE-NKERS--EALRRQQLLQEQQLREQEEYKRQLLAE--RQKRIEQQKEQRR 407 Query: 90 QLQEEMQREREA---EIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAE---EL 143 +L+E+ +REREA + R+ R ++ E+R+L++L R ++ R+ E +++ E E Sbjct: 408 RLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEY 467 Query: 144 VNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAALEVERQLFLKYI 203 + R EV Q + Q +L + RW+ + E+ + LQ L+ E+ L Sbjct: 468 IRRQLEEEQRHLEVLQQQL-LQEQAMLLECRWR-EMEEHRQAERLQRQLQQEQAYLLSLQ 525 Query: 204 LAHFRGHPALSGSPDPQAVHSLEEPLPQTSSGSCHAPKPACQLGSLDSLSAEVGVRSRSL 263 H R HP S P P P + S S HAP+P D + EV R R Sbjct: 526 HDHRRPHPQHSQQPPP--------PQQERSKPSFHAPEPKAHYEPADR-AREVEDRFRKT 576 Query: 264 GLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTRSLPKASKSEERPSSPDTSTPGSR 323 SSP+ L+ P+ S S + S + +RP+ P Sbjct: 577 N------HSSPEAQSKQTGRVLEPPVPSRSESFSNGNS-ESVHPALQRPAEPQVQWSHLA 629 Query: 324 RLSPPPSPL------PPPPPPSAHRKL 344 L SP+ P P AH L Sbjct: 630 SLKNNVSPVSRSHSFSDPSPKFAHHHL 656 Score = 55.1 bits (131), Expect = 6e-07 Identities = 45/116 (38%), Positives = 62/116 (53%), Gaps = 9/116 (7%) Query: 27 ENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSR 86 E QRRE E R + +R + E+RR ER+ +EE ER R A+ + + E ++ Sbjct: 411 EQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRR---AEEEKRRVEREQEY 467 Query: 87 ELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEE 142 RQL+EE QR E +QLL+ EQ L + RE + RQA LQRQL +E Sbjct: 468 IRRQLEEE-QRHLEVLQQQLLQ----EQAMLLECRWREME-EHRQAERLQRQLQQE 517 Score = 52.0 bits (123), Expect = 5e-06 Identities = 77/297 (25%), Positives = 126/297 (42%), Gaps = 72/297 (24%) Query: 523 RDLDRLQRESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRRQMLA---------- 572 RD RLQ+E++ L+RQ +LQ+ Q EE +RQ+LA Sbjct: 354 RDFLRLQQENKERSEALRRQQLLQEQ----------QLREQEEYKRQLLAERQKRIEQQK 403 Query: 573 -----------------LERELDQRRRECQELGAQAAPARRRGEEAETQLQAALLKNAWL 615 ++E +QRRRE +E +RR EE E + + Sbjct: 404 EQRRRLEEQQRREREARRQQEREQRRREQEE--------KRRLEELERRRK--------- 446 Query: 616 AEENGRLQAKTDWVRKVEAENSEVRGHLGRACQERDASGLIAEQLLQ-QAARGQDRQQQL 674 EE R +A+ + R+VE E +R L +E+ ++ +QLLQ QA + R +++ Sbjct: 447 -EEEERRRAEEE-KRRVEREQEYIRRQLE---EEQRHLEVLQQQLLQEQAMLLECRWREM 501 Query: 675 QRDPQKALCDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQVKGSRRPKFHARPEDYAV 734 + Q ++ L + H P + Q P Q + S +P FHA PE A Sbjct: 502 EEHRQAERLQRQLQQEQAYLLSLQHDHRRPHPQHSQQPPPPQQERS-KPSFHA-PEPKAH 559 Query: 735 SQP---NRDIQEKREASLEESPVALGESASVPQVSETVPASQPLSKKTSSQSNSSSE 788 +P R+++++ + SP A +S +V E P+ ++ S SN +SE Sbjct: 560 YEPADRAREVEDRFRKTNHSSPEA--QSKQTGRVLE-----PPVPSRSESFSNGNSE 609 >gi|41322923 plectin 1 isoform 11 [Homo sapiens] Length = 4547 Score = 73.6 bits (179), Expect = 2e-12 Identities = 206/881 (23%), Positives = 337/881 (38%), Gaps = 164/881 (18%) Query: 25 VLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQ------------- 71 V+ Q E+ R E E RA A++RQ +EEAER RRQ Sbjct: 1456 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1515 Query: 72 -LADRLRSKWEAQRSR--------ELR-QLQEEMQREREAEI---RQLLRWKEAEQRQLQ 118 LA R++++ EA R + ELR Q +E +R R+AE+ RQ+ E QR + Sbjct: 1516 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1575 Query: 119 QLLHRERDGVVRQARELQRQLAEELVN----RGHCSRPGASEVSAAQCRCRLQEVLAQLR 174 L +R + +L+R L EE V R R + A + R + L R Sbjct: 1576 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE--R 1633 Query: 175 WQTDGEQAARIRYLQAALEVERQLFLKYILAHFRGHPA-----LSGSPDPQAVHSLE--- 226 WQ +A R+R LQA EV +Q L A + A G + QAV E Sbjct: 1634 WQLKANEALRLR-LQAE-EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1691 Query: 227 ---EPLPQTSSGSCHAPKPACQLGSLDSLSAEVGVRSRSL------GLVSSACSSSP--- 274 E Q + G+ A Q E G + R L L A +++ Sbjct: 1692 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ 1751 Query: 275 --DGLLSTHASSLDCFAPACSRSLDSTRSLPKASKSEERPSSPDTSTPGSRRLSPPPSPL 332 + L+ + ++ + +R+ + +RS + SK + R L+ + L Sbjct: 1752 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR-----LEAEAGRFRELAEEAARL 1806 Query: 333 PPPPPPSAHRKLSNPRGGEGSESQPCEVLTPSPPGLGHHELIKLNWLLA----KALWVLA 388 + ++ ++ VL +G +K +A +A Sbjct: 1807 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 1866 Query: 389 RRCYTLQA-ENKQLRRAGCPYQADEKVKRLKVKRAELTGLARR--LAD---RARKLQETN 442 RR +A + ++L ++AD + + ++++A + L R+ L + R R+ E Sbjct: 1867 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1926 Query: 443 LRAVSAPIPGESC--AGLELCQVFARQRARDL---SEQASAPLAKDKQI----EELRQEC 493 + A+ A + A LEL R A D EQA A+ +Q+ E R+E Sbjct: 1927 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 1986 Query: 494 HLLQARVASGPCSDLHTGRGGPCTQWLNVRDLDRL-------QRESQREVLRLQRQLMLQ 546 + RV ++ R + +++RL +R +R RQL L Sbjct: 1987 ---EERVQKSLAAEEEAARQRKAA----LEEVERLKAKVEEARRLRERAEQESARQLQLA 2039 Query: 547 QGNGGAWPEAGGQSATCEE------VRRQMLALERELDQRRRECQELGAQAAPARRRGEE 600 Q EA + EE V+++ L++ L Q + +L +A ARR EE Sbjct: 2040 Q-------EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2092 Query: 601 AE--------------------------TQLQAALLKNAWLAEENGRLQAKTDWVRKVEA 634 AE + QA A A E R +A+ + R+ +A Sbjct: 2093 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA 2152 Query: 635 ENSEVRGHLGRACQERDASGLIAEQLLQQAARGQD-----RQQQLQRDPQKALCDLHPSW 689 E + +R A E + AEQ L+Q A+ + R Q + D QK L D Sbjct: 2153 EQAALR-QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD----- 2206 Query: 690 KEIQALQCRPGHPPEQPWETSQMPES------QVKGSRRPKFHARPEDYAVSQPNRD--- 740 +E+Q L+ E + SQ+ E Q++ + K E+ A+ ++D Sbjct: 2207 EELQRLK---AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ 2263 Query: 741 --IQEKREASLEES------PVALGESASVPQVSETVPASQ 773 +QE+ E + + VA E+A + Q++E A Q Sbjct: 2264 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2304 Score = 58.2 bits (139), Expect = 7e-08 Identities = 175/803 (21%), Positives = 304/803 (37%), Gaps = 77/803 (9%) Query: 34 EKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSRELRQLQE 93 E LR E ER AE++R RER EA E+++ ++ +AQ RE ++LQ+ Sbjct: 1339 ETLRRMEEEERL---AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1395 Query: 94 EMQRE---RE---AEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQR---QLAEE-- 142 MQ E RE + +Q R + E +QL+Q E RQA +R ++ EE Sbjct: 1396 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1455 Query: 143 ---LVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAALEVERQLF 199 L + G +E R R +E AQ R E+A R+R Q E +R+ Sbjct: 1456 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQ--EEAERLR-RQVQDESQRKRQ 1512 Query: 200 LKYILAHFRGHPALSGSPDPQAVHSLEEPLPQTSSGSCHAPKPACQLGSLDSLSAEVGVR 259 + LA A + +A+ +LEE Q + + ++ E R Sbjct: 1513 AEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1572 Query: 260 SRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTRSLPKASKSEERPSSP---- 315 S L S S + + + A A R R+ +A R + Sbjct: 1573 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1632 Query: 316 ----DTSTPGSRRLSPPPSPLPPPPPPSAHRKLSNPRGGEGSESQPCEVLTPSPPGLGHH 371 + RL + K E E L Sbjct: 1633 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1692 Query: 372 ELIKLNWL--------LAKALWVLARRCYTLQAENK-----------QLRRAGCPYQADE 412 EL K L LA ++ R T Q E + Q A + E Sbjct: 1693 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1752 Query: 413 KVKRLKVKRAELTGLARRLADRARKLQETNLRAVSAPIPGESCAG--LELCQVFARQRAR 470 L RAE+ L LA +AR +E+ + + E+ AG EL + AR RA Sbjct: 1753 LEAELAKVRAEMEVL---LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1809 Query: 471 DLSEQASAPLAKDKQIEELRQECHLLQARVAS-GPCSDLHTGRGGPCTQWLNVRDLDRLQ 529 + LA++ + + +L ++A+ G + L T + + +RL+ Sbjct: 1810 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE--KEAENERLR 1867 Query: 530 RESQREVLRLQRQLMLQQGNGGAWPE---AGGQSATCEEVRRQMLALERELDQRRRECQE 586 R ++ E + +R+L Q A E A + A+ E+ RQ +E L QRR+ +E Sbjct: 1868 RLAEDEAFQ-RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1926 Query: 587 -LGAQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLGR 645 L +A+ + +AE +L+ +++ + QA+ + R+ + E R R Sbjct: 1927 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR--R 1984 Query: 646 ACQERDASGLIAEQLLQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQALQCRPGHPPEQ 705 +ER L AE+ + A + + ++++R L +E + L+ R + Sbjct: 1985 EAEERVQKSLAAEE--EAARQRKAALEEVER--------LKAKVEEARRLRER-----AE 2029 Query: 706 PWETSQMPESQVKGSRRPKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQV 765 Q+ +Q +R + + +AV Q +++Q+ + GE+ + + Sbjct: 2030 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2089 Query: 766 SETVPASQPLSKKTSSQSNSSSE 788 +E ++ +++ ++QS E Sbjct: 2090 AEEAEEARVQAEREAAQSRRQVE 2112 Score = 54.3 bits (129), Expect = 1e-06 Identities = 59/188 (31%), Positives = 89/188 (47%), Gaps = 24/188 (12%) Query: 23 AAVLENQRRELE-KLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWE 81 AA E +RRE E +++ L AE A R+R AA E R +A+ E A RLR + E Sbjct: 1976 AAEEERRRREAEERVQKSLAAEE---EAARQRKAALEEVERLKAKVEE---ARRLRERAE 2029 Query: 82 AQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGV--VRQARELQRQL 139 + +R+L+ QE Q+ +AE + + ++++LQQ L +E+ + +R E R+ Sbjct: 2030 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2089 Query: 140 AEELVN-RGHCSRPGA--------------SEVSAAQCRCRLQEVLAQLRWQTDGEQAAR 184 AEE R R A S AQ R + Q +LR + + E A R Sbjct: 2090 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2149 Query: 185 IRYLQAAL 192 + QAAL Sbjct: 2150 AQAEQAAL 2157 Score = 50.8 bits (120), Expect = 1e-05 Identities = 52/191 (27%), Positives = 96/191 (50%), Gaps = 23/191 (12%) Query: 24 AVLENQRRELEKLR-AELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEA 82 +VL+ R E E R A EAE A +AER AA+ R+ EEAER ++ ++ +++ +A Sbjct: 2074 SVLDQLRGEAEAARRAAEEAEEARVQAERE--AAQSRRQVEEAERLKQSAEEQAQARAQA 2131 Query: 83 QRSRELRQLQEEMQREREAEIRQ-LLRWKEAEQRQLQQLLHRE-RDGVVRQARELQRQLA 140 Q + E + + E + R A+ Q LR K+A ++++ H++ + +RQ +++++L Sbjct: 2132 QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK--HKKFAEQTLRQKAQVEQELT 2189 Query: 141 E---ELVNRGH--------CSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQ 189 +L H R A AA+ R +++E L +R Q + + L+ Sbjct: 2190 TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME-----ELSKLK 2244 Query: 190 AALEVERQLFL 200 A +E E + + Sbjct: 2245 ARIEAENRALI 2255 Score = 49.3 bits (116), Expect = 3e-05 Identities = 56/186 (30%), Positives = 89/186 (47%), Gaps = 20/186 (10%) Query: 29 QRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSREL 88 Q EL KL+A +EAE + +R L+EEAE+ ++ + R AQ + L Sbjct: 2236 QMEELSKLKARIEAENRALILRDKDNT--QRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2293 Query: 89 RQLQEEMQREREAEIRQLLRWK-----EAEQRQLQ-QLLHRERDGVVRQARELQ------ 136 RQL EE ++ A ++L+ K EA + + + +LL ++++ QAR LQ Sbjct: 2294 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2353 Query: 137 -RQLAEE---LVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAAL 192 +QLAEE R E+SA R +L+ V R Q E+ A+ R+ + A Sbjct: 2354 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR-VAEMSRAQARAEEDAQ-RFRKQAE 2411 Query: 193 EVERQL 198 E+ +L Sbjct: 2412 EIGEKL 2417 Score = 47.4 bits (111), Expect = 1e-04 Identities = 56/204 (27%), Positives = 81/204 (39%), Gaps = 46/204 (22%) Query: 24 AVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQ 83 A L+ + + R ELEAE A RAE A + AE E R +++ + + EA+ Sbjct: 1737 ARLQREAAAATQKRQELEAELAKVRAEMEVLLAS----KARAEEESRSTSEKSKQRLEAE 1792 Query: 84 RSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEEL 143 R R+L EE R R L + QRQL + + RQ E +R LAE+L Sbjct: 1793 AGR-FRELAEEAARLR------ALAEEAKRQRQLAE------EDAARQRAEAERVLAEKL 1839 Query: 144 VNRGHCSRPGAS-----------------------------EVSAAQCRCRLQEVLAQLR 174 G +R E AAQ + ++E LAQLR Sbjct: 1840 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1899 Query: 175 WQTDGEQAARIRYLQAALEVERQL 198 +D E + ++ L RQ+ Sbjct: 1900 KASDSELERQKGLVEDTLRQRRQV 1923 Score = 46.6 bits (109), Expect = 2e-04 Identities = 58/189 (30%), Positives = 90/189 (47%), Gaps = 36/189 (19%) Query: 32 ELEKLRAEL-EAERAGWRAERRRFAARER-----QLREEAERERRQLADRLRSKWEAQR- 84 EL++L+AE EA R + E F+ R + +L+ E E R L LR K QR Sbjct: 2208 ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI--LRDKDNTQRF 2265 Query: 85 ----SRELRQLQEEMQR-----EREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQAREL 135 + +++Q+ EE R + A +RQL A+QR L + + +E+ V++A L Sbjct: 2266 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2325 Query: 136 QRQLAEELVNRGHCSRPGASEVSAAQCRCRLQE----VLAQLRWQTDGEQ----AARIRY 187 + + EL+ + E++ Q R RLQE + QL +T G Q A R R Sbjct: 2326 KAE--AELLQQ-------QKELAQEQAR-RLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2375 Query: 188 LQAALEVER 196 L+ + E ER Sbjct: 2376 LEMSAEAER 2384 Score = 44.7 bits (104), Expect = 8e-04 Identities = 62/184 (33%), Positives = 86/184 (46%), Gaps = 15/184 (8%) Query: 22 AAAVLENQR--RELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSK 79 A A E QR + LE+LR L+AE A R R+ R RQ++ E +R L+SK Sbjct: 1525 AEAAREKQRALQALEELR--LQAEEAE-RRLRQAEVERARQVQVALETAQRSAEAELQSK 1581 Query: 80 WEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQL-LHRERDGVVRQARELQRQ 138 A + + QL+ +Q E A + QL +EAE+R QQ R R+ R+ Q + Sbjct: 1582 -RASFAEKTAQLERSLQEEHVA-VAQLR--EEAERRAQQQAEAERAREEAERELERWQLK 1637 Query: 139 LAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDG---EQAARIRYL-QAALEV 194 E L R A + S AQ Q+ A+ + G EQA R R L + LE Sbjct: 1638 ANEALRLRLQAEEV-AQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK 1696 Query: 195 ERQL 198 +RQL Sbjct: 1697 QRQL 1700 Score = 44.7 bits (104), Expect = 8e-04 Identities = 33/122 (27%), Positives = 67/122 (54%), Gaps = 11/122 (9%) Query: 40 LEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSRELRQLQEEMQRER 99 +E E+A + A+ +QLREE +R+++Q+ E +R R + ++E +R+ Sbjct: 2509 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM--------EQERQRLVASMEEARRRQH 2560 Query: 100 EAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEELVNRGHCSRPGASEVSA 159 EAE + +R K+ E +QL+Q ++ + + + + L+ QL + L + + + EV+A Sbjct: 2561 EAE--EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL-QLLEEQHRAALAHSEEVTA 2617 Query: 160 AQ 161 +Q Sbjct: 2618 SQ 2619 Score = 41.2 bits (95), Expect = 0.008 Identities = 34/125 (27%), Positives = 61/125 (48%), Gaps = 20/125 (16%) Query: 30 RRELEKLRAELEAERAGWRAERRRFAARER------------QLREEAERERRQLADRLR 77 R E + R +AE G + R A +E+ Q +AER R +A+ R Sbjct: 2398 RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER 2457 Query: 78 SKWEAQRSRELRQLQ-EEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQ 136 K + Q+ +L QL+ EEMQ ++ ++ Q E + LQQ E+D ++++ R ++ Sbjct: 2458 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQ-------ETQALQQSFLSEKDSLLQRERFIE 2510 Query: 137 RQLAE 141 ++ A+ Sbjct: 2511 QEKAK 2515 Score = 40.4 bits (93), Expect = 0.014 Identities = 40/140 (28%), Positives = 65/140 (46%), Gaps = 20/140 (14%) Query: 26 LENQRRELEKLRAELEAERAGWRAER----------RRFAARERQLREEAERERRQLADR 75 LE + L+KLRA+ EA++ + A R R R + E ER R ++A + Sbjct: 1125 LEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA-Q 1183 Query: 76 LRSKWEA------QRSRELRQLQEEMQREREA--EIRQLLRWKEAEQRQLQQLLHRERDG 127 L +W+A R REL QL +++ RE+ + L+ Q Q+Q + + Sbjct: 1184 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1243 Query: 128 VVRQARELQRQLAEELVNRG 147 V Q R+ ++ L EE+ G Sbjct: 1244 VREQLRQ-EQALLEEIERHG 1262 Score = 39.7 bits (91), Expect = 0.024 Identities = 42/174 (24%), Positives = 72/174 (41%), Gaps = 7/174 (4%) Query: 24 AVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQ 83 A +E R+ L + A +++R FA + QL + E +A +LR EA+ Sbjct: 1555 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVA-QLRE--EAE 1611 Query: 84 RSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEEL 143 R Q Q E +R RE R+L RW+ L+ L E + + + + +E Sbjct: 1612 RRA---QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1668 Query: 144 VNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAALEVERQ 197 R R G +E A + R ++ L + R +G R+ Q + + + Sbjct: 1669 AER-EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE 1721 Score = 39.7 bits (91), Expect = 0.024 Identities = 53/186 (28%), Positives = 84/186 (45%), Gaps = 16/186 (8%) Query: 23 AAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWE- 81 AA L +E +LR E + A RA + + Q +EA R + + A+ L+ + E Sbjct: 2280 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE-AELLQQQKEL 2338 Query: 82 -AQRSRELRQLQEEMQREREAEIRQLLRWKEAE-QRQLQQLLHRERDGVVRQARELQRQL 139 +++R L++ +E+M ++ E + R EAE QRQL+ ER + + Sbjct: 2339 AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2398 Query: 140 AEELVNRGHCSRPGASEVS--------AAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAA 191 AEE R R A E+ A Q + L + L R Q+D A R+R A Sbjct: 2399 AEEDAQR---FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD-HDAERLREAIAE 2454 Query: 192 LEVERQ 197 LE E++ Sbjct: 2455 LEREKE 2460 Score = 38.5 bits (88), Expect = 0.054 Identities = 35/136 (25%), Positives = 67/136 (49%), Gaps = 20/136 (14%) Query: 26 LENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRS 85 +E ++ +LE+L + A+ R E++R +++Q+ +E +R + + R + EA Sbjct: 2509 IEQEKAKLEQLFQDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEA--- 2562 Query: 86 RELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEELVN 145 EE R ++ E++QL E ++RQ ++LL E + Q + L+ Q L Sbjct: 2563 -------EEGVRRKQEELQQL----EQQRRQQEELLAEENQRLREQLQLLEEQHRAAL-- 2609 Query: 146 RGHCSRPGASEVSAAQ 161 H AS+V+A + Sbjct: 2610 -AHSEEVTASQVAATK 2624 Score = 37.7 bits (86), Expect = 0.092 Identities = 34/124 (27%), Positives = 55/124 (44%), Gaps = 34/124 (27%) Query: 103 IRQLLRWKEAEQRQLQQLLHRERDGVV------------------------RQARELQRQ 138 I + LR E E+R +Q ER+ + R+A+ELQ++ Sbjct: 1337 ISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR 1396 Query: 139 LAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAA----LEV 194 + EE+V R + V A Q + +QE L QLR ++ E A+ R +AA L + Sbjct: 1397 MQEEVVRREEAA------VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1450 Query: 195 ERQL 198 E ++ Sbjct: 1451 EEEI 1454 Score = 37.7 bits (86), Expect = 0.092 Identities = 58/251 (23%), Positives = 109/251 (43%), Gaps = 42/251 (16%) Query: 393 TLQAENKQLRRAGCPYQADEKVKRLKVKRAELTGL-------ARRLADRARKLQETNLRA 445 TL+AE ++ + + +RLK++ AE++ A+R +A ++ E R Sbjct: 2367 TLEAERQR------QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2420 Query: 446 VSAPIPGESCAGLELCQVFARQRARDLSEQASAPLAKDKQIEELRQECHLLQARVASGPC 505 A E ++ ++ +Q D A +++ E+L+QE LLQ + Sbjct: 2421 ELAT--QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK-----S 2473 Query: 506 SDLHTGRGGPCTQWLNVRDLDRLQRE--SQREVLRLQRQLMLQQGNGGAWPEAGGQSATC 563 ++ T + Q +++ LQ+ S+++ L LQR+ ++Q + A Sbjct: 2474 EEMQTVQ-----QEQLLQETQALQQSFLSEKDSL-LQRERFIEQEKAKLEQLFQDEVAKA 2527 Query: 564 EEVRRQMLALERELDQRRRECQELGAQAAPARRRGEEAETQL-----------QAALLKN 612 +++R + +++++Q R Q L A ARRR EAE + Q + Sbjct: 2528 QQLREEQQRQQQQMEQER---QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE 2584 Query: 613 AWLAEENGRLQ 623 LAEEN RL+ Sbjct: 2585 ELLAEENQRLR 2595 Score = 37.7 bits (86), Expect = 0.092 Identities = 38/136 (27%), Positives = 71/136 (52%), Gaps = 16/136 (11%) Query: 26 LENQRRE----LEKLR---AELEAERAGWRAERRRFAARERQLR----EEAERERRQLAD 74 LE QR++ E+LR AELE E+ + E + + +++ E+ +E + L Sbjct: 2434 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2493 Query: 75 RLRSKWEA--QRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQA 132 S+ ++ QR R + Q + ++++ + E+ + + +E +QRQ QQ + +ER +V Sbjct: 2494 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ-QQQMEQERQRLVASM 2552 Query: 133 RELQRQL--AEELVNR 146 E +R+ AEE V R Sbjct: 2553 EEARRRQHEAEEGVRR 2568 Score = 36.6 bits (83), Expect = 0.21 Identities = 55/186 (29%), Positives = 82/186 (44%), Gaps = 23/186 (12%) Query: 23 AAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERE--RRQLADR--LRS 78 AA Q E E+L+ E E+A RA+ + A +LR+EAE+E RR A++ LR Sbjct: 2104 AAQSRRQVEEAERLKQSAE-EQAQARAQAQ---AAAEKLRKEAEQEAARRAQAEQAALRQ 2159 Query: 79 KWEAQRSRELRQLQEEMQREREAEIRQ---LLRWKEAEQRQLQQLLHRERDGVVRQAREL 135 K A E + E ++A++ Q LR + E + LL E + +A E Sbjct: 2160 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2219 Query: 136 QR---QLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAAL 192 R Q+ EEL + R E+S + R + LR D Q R+LQ Sbjct: 2220 ARQRSQVEEELFS----VRVQMEELSKLKARIEAENRALILR-DKDNTQ----RFLQEEA 2270 Query: 193 EVERQL 198 E +Q+ Sbjct: 2271 EKMKQV 2276 Score = 33.1 bits (74), Expect = 2.3 Identities = 34/121 (28%), Positives = 52/121 (42%), Gaps = 12/121 (9%) Query: 22 AAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLR------EEAERERRQLADR 75 A + E Q+R+ +++ E + A RRR E +R ++ E++RRQ + Sbjct: 2527 AQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL 2586 Query: 76 LRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQAREL 135 L E QR RE QL EE R A ++ A Q + L RD + A E Sbjct: 2587 LAE--ENQRLREQLQLLEEQHRAALAHSEEV----TASQVAATKTLPNGRDALDGPAAEA 2640 Query: 136 Q 136 + Sbjct: 2641 E 2641 Score = 31.2 bits (69), Expect = 8.6 Identities = 64/283 (22%), Positives = 112/283 (39%), Gaps = 49/283 (17%) Query: 399 KQLRRAGCPYQADEKVKRLKVKRAELTGLARRLADRARKLQETNLRAVSAPIPGESCAGL 458 ++LR A + +++ + + K +L + + + LQET +A+ E + L Sbjct: 2446 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQET--QALQQSFLSEKDSLL 2503 Query: 459 ELCQVFARQRARDLSEQASAPLAKDKQI--EELRQECHLLQAR---VASGPCSDLHTGRG 513 + + +++A+ L + +AK +Q+ E+ RQ+ + Q R VAS Sbjct: 2504 QRERFIEQEKAK-LEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVAS----------- 2551 Query: 514 GPCTQWLNVRDLDRLQRESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRRQMLAL 573 + + R Q E++ V R Q +L E+ RRQ L Sbjct: 2552 --------MEEARRRQHEAEEGVRRKQEELQ-----------------QLEQQRRQQEEL 2586 Query: 574 ERELDQRRRECQELGAQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVE 633 E +QR RE +L + A E T Q A K NGR A + E Sbjct: 2587 LAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTL----PNGR-DALDGPAAEAE 2641 Query: 634 AENSEVRGHLGRACQERDASGLIAEQLLQQAARGQDRQQQLQR 676 E+S + Q +G+++ + LQ+ A+G +L R Sbjct: 2642 PEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELAR 2684 >gi|41322914 plectin 1 isoform 10 [Homo sapiens] Length = 4551 Score = 73.6 bits (179), Expect = 2e-12 Identities = 206/881 (23%), Positives = 337/881 (38%), Gaps = 164/881 (18%) Query: 25 VLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQ------------- 71 V+ Q E+ R E E RA A++RQ +EEAER RRQ Sbjct: 1460 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1519 Query: 72 -LADRLRSKWEAQRSR--------ELR-QLQEEMQREREAEI---RQLLRWKEAEQRQLQ 118 LA R++++ EA R + ELR Q +E +R R+AE+ RQ+ E QR + Sbjct: 1520 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1579 Query: 119 QLLHRERDGVVRQARELQRQLAEELVN----RGHCSRPGASEVSAAQCRCRLQEVLAQLR 174 L +R + +L+R L EE V R R + A + R + L R Sbjct: 1580 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE--R 1637 Query: 175 WQTDGEQAARIRYLQAALEVERQLFLKYILAHFRGHPA-----LSGSPDPQAVHSLE--- 226 WQ +A R+R LQA EV +Q L A + A G + QAV E Sbjct: 1638 WQLKANEALRLR-LQAE-EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1695 Query: 227 ---EPLPQTSSGSCHAPKPACQLGSLDSLSAEVGVRSRSL------GLVSSACSSSP--- 274 E Q + G+ A Q E G + R L L A +++ Sbjct: 1696 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ 1755 Query: 275 --DGLLSTHASSLDCFAPACSRSLDSTRSLPKASKSEERPSSPDTSTPGSRRLSPPPSPL 332 + L+ + ++ + +R+ + +RS + SK + R L+ + L Sbjct: 1756 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR-----LEAEAGRFRELAEEAARL 1810 Query: 333 PPPPPPSAHRKLSNPRGGEGSESQPCEVLTPSPPGLGHHELIKLNWLLA----KALWVLA 388 + ++ ++ VL +G +K +A +A Sbjct: 1811 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 1870 Query: 389 RRCYTLQA-ENKQLRRAGCPYQADEKVKRLKVKRAELTGLARR--LAD---RARKLQETN 442 RR +A + ++L ++AD + + ++++A + L R+ L + R R+ E Sbjct: 1871 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1930 Query: 443 LRAVSAPIPGESC--AGLELCQVFARQRARDL---SEQASAPLAKDKQI----EELRQEC 493 + A+ A + A LEL R A D EQA A+ +Q+ E R+E Sbjct: 1931 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 1990 Query: 494 HLLQARVASGPCSDLHTGRGGPCTQWLNVRDLDRL-------QRESQREVLRLQRQLMLQ 546 + RV ++ R + +++RL +R +R RQL L Sbjct: 1991 ---EERVQKSLAAEEEAARQRKAA----LEEVERLKAKVEEARRLRERAEQESARQLQLA 2043 Query: 547 QGNGGAWPEAGGQSATCEE------VRRQMLALERELDQRRRECQELGAQAAPARRRGEE 600 Q EA + EE V+++ L++ L Q + +L +A ARR EE Sbjct: 2044 Q-------EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2096 Query: 601 AE--------------------------TQLQAALLKNAWLAEENGRLQAKTDWVRKVEA 634 AE + QA A A E R +A+ + R+ +A Sbjct: 2097 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA 2156 Query: 635 ENSEVRGHLGRACQERDASGLIAEQLLQQAARGQD-----RQQQLQRDPQKALCDLHPSW 689 E + +R A E + AEQ L+Q A+ + R Q + D QK L D Sbjct: 2157 EQAALR-QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD----- 2210 Query: 690 KEIQALQCRPGHPPEQPWETSQMPES------QVKGSRRPKFHARPEDYAVSQPNRD--- 740 +E+Q L+ E + SQ+ E Q++ + K E+ A+ ++D Sbjct: 2211 EELQRLK---AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ 2267 Query: 741 --IQEKREASLEES------PVALGESASVPQVSETVPASQ 773 +QE+ E + + VA E+A + Q++E A Q Sbjct: 2268 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2308 Score = 58.2 bits (139), Expect = 7e-08 Identities = 175/803 (21%), Positives = 304/803 (37%), Gaps = 77/803 (9%) Query: 34 EKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSRELRQLQE 93 E LR E ER AE++R RER EA E+++ ++ +AQ RE ++LQ+ Sbjct: 1343 ETLRRMEEEERL---AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1399 Query: 94 EMQRE---RE---AEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQR---QLAEE-- 142 MQ E RE + +Q R + E +QL+Q E RQA +R ++ EE Sbjct: 1400 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1459 Query: 143 ---LVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAALEVERQLF 199 L + G +E R R +E AQ R E+A R+R Q E +R+ Sbjct: 1460 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQ--EEAERLR-RQVQDESQRKRQ 1516 Query: 200 LKYILAHFRGHPALSGSPDPQAVHSLEEPLPQTSSGSCHAPKPACQLGSLDSLSAEVGVR 259 + LA A + +A+ +LEE Q + + ++ E R Sbjct: 1517 AEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1576 Query: 260 SRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTRSLPKASKSEERPSSP---- 315 S L S S + + + A A R R+ +A R + Sbjct: 1577 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1636 Query: 316 ----DTSTPGSRRLSPPPSPLPPPPPPSAHRKLSNPRGGEGSESQPCEVLTPSPPGLGHH 371 + RL + K E E L Sbjct: 1637 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1696 Query: 372 ELIKLNWL--------LAKALWVLARRCYTLQAENK-----------QLRRAGCPYQADE 412 EL K L LA ++ R T Q E + Q A + E Sbjct: 1697 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1756 Query: 413 KVKRLKVKRAELTGLARRLADRARKLQETNLRAVSAPIPGESCAG--LELCQVFARQRAR 470 L RAE+ L LA +AR +E+ + + E+ AG EL + AR RA Sbjct: 1757 LEAELAKVRAEMEVL---LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1813 Query: 471 DLSEQASAPLAKDKQIEELRQECHLLQARVAS-GPCSDLHTGRGGPCTQWLNVRDLDRLQ 529 + LA++ + + +L ++A+ G + L T + + +RL+ Sbjct: 1814 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE--KEAENERLR 1871 Query: 530 RESQREVLRLQRQLMLQQGNGGAWPE---AGGQSATCEEVRRQMLALERELDQRRRECQE 586 R ++ E + +R+L Q A E A + A+ E+ RQ +E L QRR+ +E Sbjct: 1872 RLAEDEAFQ-RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1930 Query: 587 -LGAQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLGR 645 L +A+ + +AE +L+ +++ + QA+ + R+ + E R R Sbjct: 1931 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR--R 1988 Query: 646 ACQERDASGLIAEQLLQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQALQCRPGHPPEQ 705 +ER L AE+ + A + + ++++R L +E + L+ R + Sbjct: 1989 EAEERVQKSLAAEE--EAARQRKAALEEVER--------LKAKVEEARRLRER-----AE 2033 Query: 706 PWETSQMPESQVKGSRRPKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQV 765 Q+ +Q +R + + +AV Q +++Q+ + GE+ + + Sbjct: 2034 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2093 Query: 766 SETVPASQPLSKKTSSQSNSSSE 788 +E ++ +++ ++QS E Sbjct: 2094 AEEAEEARVQAEREAAQSRRQVE 2116 Score = 54.3 bits (129), Expect = 1e-06 Identities = 59/188 (31%), Positives = 89/188 (47%), Gaps = 24/188 (12%) Query: 23 AAVLENQRRELE-KLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWE 81 AA E +RRE E +++ L AE A R+R AA E R +A+ E A RLR + E Sbjct: 1980 AAEEERRRREAEERVQKSLAAEE---EAARQRKAALEEVERLKAKVEE---ARRLRERAE 2033 Query: 82 AQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGV--VRQARELQRQL 139 + +R+L+ QE Q+ +AE + + ++++LQQ L +E+ + +R E R+ Sbjct: 2034 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2093 Query: 140 AEELVN-RGHCSRPGA--------------SEVSAAQCRCRLQEVLAQLRWQTDGEQAAR 184 AEE R R A S AQ R + Q +LR + + E A R Sbjct: 2094 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2153 Query: 185 IRYLQAAL 192 + QAAL Sbjct: 2154 AQAEQAAL 2161 Score = 50.8 bits (120), Expect = 1e-05 Identities = 52/191 (27%), Positives = 96/191 (50%), Gaps = 23/191 (12%) Query: 24 AVLENQRRELEKLR-AELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEA 82 +VL+ R E E R A EAE A +AER AA+ R+ EEAER ++ ++ +++ +A Sbjct: 2078 SVLDQLRGEAEAARRAAEEAEEARVQAERE--AAQSRRQVEEAERLKQSAEEQAQARAQA 2135 Query: 83 QRSRELRQLQEEMQREREAEIRQ-LLRWKEAEQRQLQQLLHRE-RDGVVRQARELQRQLA 140 Q + E + + E + R A+ Q LR K+A ++++ H++ + +RQ +++++L Sbjct: 2136 QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK--HKKFAEQTLRQKAQVEQELT 2193 Query: 141 E---ELVNRGH--------CSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQ 189 +L H R A AA+ R +++E L +R Q + + L+ Sbjct: 2194 TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME-----ELSKLK 2248 Query: 190 AALEVERQLFL 200 A +E E + + Sbjct: 2249 ARIEAENRALI 2259 Score = 49.3 bits (116), Expect = 3e-05 Identities = 56/186 (30%), Positives = 89/186 (47%), Gaps = 20/186 (10%) Query: 29 QRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSREL 88 Q EL KL+A +EAE + +R L+EEAE+ ++ + R AQ + L Sbjct: 2240 QMEELSKLKARIEAENRALILRDKDNT--QRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2297 Query: 89 RQLQEEMQREREAEIRQLLRWK-----EAEQRQLQ-QLLHRERDGVVRQARELQ------ 136 RQL EE ++ A ++L+ K EA + + + +LL ++++ QAR LQ Sbjct: 2298 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2357 Query: 137 -RQLAEE---LVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAAL 192 +QLAEE R E+SA R +L+ V R Q E+ A+ R+ + A Sbjct: 2358 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR-VAEMSRAQARAEEDAQ-RFRKQAE 2415 Query: 193 EVERQL 198 E+ +L Sbjct: 2416 EIGEKL 2421 Score = 47.4 bits (111), Expect = 1e-04 Identities = 56/204 (27%), Positives = 81/204 (39%), Gaps = 46/204 (22%) Query: 24 AVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQ 83 A L+ + + R ELEAE A RAE A + AE E R +++ + + EA+ Sbjct: 1741 ARLQREAAAATQKRQELEAELAKVRAEMEVLLAS----KARAEEESRSTSEKSKQRLEAE 1796 Query: 84 RSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEEL 143 R R+L EE R R L + QRQL + + RQ E +R LAE+L Sbjct: 1797 AGR-FRELAEEAARLR------ALAEEAKRQRQLAE------EDAARQRAEAERVLAEKL 1843 Query: 144 VNRGHCSRPGAS-----------------------------EVSAAQCRCRLQEVLAQLR 174 G +R E AAQ + ++E LAQLR Sbjct: 1844 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1903 Query: 175 WQTDGEQAARIRYLQAALEVERQL 198 +D E + ++ L RQ+ Sbjct: 1904 KASDSELERQKGLVEDTLRQRRQV 1927 Score = 46.6 bits (109), Expect = 2e-04 Identities = 58/189 (30%), Positives = 90/189 (47%), Gaps = 36/189 (19%) Query: 32 ELEKLRAEL-EAERAGWRAERRRFAARER-----QLREEAERERRQLADRLRSKWEAQR- 84 EL++L+AE EA R + E F+ R + +L+ E E R L LR K QR Sbjct: 2212 ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI--LRDKDNTQRF 2269 Query: 85 ----SRELRQLQEEMQR-----EREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQAREL 135 + +++Q+ EE R + A +RQL A+QR L + + +E+ V++A L Sbjct: 2270 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2329 Query: 136 QRQLAEELVNRGHCSRPGASEVSAAQCRCRLQE----VLAQLRWQTDGEQ----AARIRY 187 + + EL+ + E++ Q R RLQE + QL +T G Q A R R Sbjct: 2330 KAE--AELLQQ-------QKELAQEQAR-RLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2379 Query: 188 LQAALEVER 196 L+ + E ER Sbjct: 2380 LEMSAEAER 2388 Score = 44.7 bits (104), Expect = 8e-04 Identities = 62/184 (33%), Positives = 86/184 (46%), Gaps = 15/184 (8%) Query: 22 AAAVLENQR--RELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSK 79 A A E QR + LE+LR L+AE A R R+ R RQ++ E +R L+SK Sbjct: 1529 AEAAREKQRALQALEELR--LQAEEAE-RRLRQAEVERARQVQVALETAQRSAEAELQSK 1585 Query: 80 WEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQL-LHRERDGVVRQARELQRQ 138 A + + QL+ +Q E A + QL +EAE+R QQ R R+ R+ Q + Sbjct: 1586 -RASFAEKTAQLERSLQEEHVA-VAQLR--EEAERRAQQQAEAERAREEAERELERWQLK 1641 Query: 139 LAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDG---EQAARIRYL-QAALEV 194 E L R A + S AQ Q+ A+ + G EQA R R L + LE Sbjct: 1642 ANEALRLRLQAEEV-AQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK 1700 Query: 195 ERQL 198 +RQL Sbjct: 1701 QRQL 1704 Score = 44.7 bits (104), Expect = 8e-04 Identities = 33/122 (27%), Positives = 67/122 (54%), Gaps = 11/122 (9%) Query: 40 LEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSRELRQLQEEMQRER 99 +E E+A + A+ +QLREE +R+++Q+ E +R R + ++E +R+ Sbjct: 2513 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM--------EQERQRLVASMEEARRRQH 2564 Query: 100 EAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEELVNRGHCSRPGASEVSA 159 EAE + +R K+ E +QL+Q ++ + + + + L+ QL + L + + + EV+A Sbjct: 2565 EAE--EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL-QLLEEQHRAALAHSEEVTA 2621 Query: 160 AQ 161 +Q Sbjct: 2622 SQ 2623 Score = 41.2 bits (95), Expect = 0.008 Identities = 34/125 (27%), Positives = 61/125 (48%), Gaps = 20/125 (16%) Query: 30 RRELEKLRAELEAERAGWRAERRRFAARER------------QLREEAERERRQLADRLR 77 R E + R +AE G + R A +E+ Q +AER R +A+ R Sbjct: 2402 RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER 2461 Query: 78 SKWEAQRSRELRQLQ-EEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQ 136 K + Q+ +L QL+ EEMQ ++ ++ Q E + LQQ E+D ++++ R ++ Sbjct: 2462 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQ-------ETQALQQSFLSEKDSLLQRERFIE 2514 Query: 137 RQLAE 141 ++ A+ Sbjct: 2515 QEKAK 2519 Score = 40.4 bits (93), Expect = 0.014 Identities = 40/140 (28%), Positives = 65/140 (46%), Gaps = 20/140 (14%) Query: 26 LENQRRELEKLRAELEAERAGWRAER----------RRFAARERQLREEAERERRQLADR 75 LE + L+KLRA+ EA++ + A R R R + E ER R ++A + Sbjct: 1129 LEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA-Q 1187 Query: 76 LRSKWEA------QRSRELRQLQEEMQREREA--EIRQLLRWKEAEQRQLQQLLHRERDG 127 L +W+A R REL QL +++ RE+ + L+ Q Q+Q + + Sbjct: 1188 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1247 Query: 128 VVRQARELQRQLAEELVNRG 147 V Q R+ ++ L EE+ G Sbjct: 1248 VREQLRQ-EQALLEEIERHG 1266 Score = 39.7 bits (91), Expect = 0.024 Identities = 42/174 (24%), Positives = 72/174 (41%), Gaps = 7/174 (4%) Query: 24 AVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQ 83 A +E R+ L + A +++R FA + QL + E +A +LR EA+ Sbjct: 1559 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVA-QLRE--EAE 1615 Query: 84 RSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEEL 143 R Q Q E +R RE R+L RW+ L+ L E + + + + +E Sbjct: 1616 RRA---QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1672 Query: 144 VNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAALEVERQ 197 R R G +E A + R ++ L + R +G R+ Q + + + Sbjct: 1673 AER-EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE 1725 Score = 39.7 bits (91), Expect = 0.024 Identities = 53/186 (28%), Positives = 84/186 (45%), Gaps = 16/186 (8%) Query: 23 AAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWE- 81 AA L +E +LR E + A RA + + Q +EA R + + A+ L+ + E Sbjct: 2284 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE-AELLQQQKEL 2342 Query: 82 -AQRSRELRQLQEEMQREREAEIRQLLRWKEAE-QRQLQQLLHRERDGVVRQARELQRQL 139 +++R L++ +E+M ++ E + R EAE QRQL+ ER + + Sbjct: 2343 AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2402 Query: 140 AEELVNRGHCSRPGASEVS--------AAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAA 191 AEE R R A E+ A Q + L + L R Q+D A R+R A Sbjct: 2403 AEEDAQR---FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD-HDAERLREAIAE 2458 Query: 192 LEVERQ 197 LE E++ Sbjct: 2459 LEREKE 2464 Score = 38.5 bits (88), Expect = 0.054 Identities = 35/136 (25%), Positives = 67/136 (49%), Gaps = 20/136 (14%) Query: 26 LENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRS 85 +E ++ +LE+L + A+ R E++R +++Q+ +E +R + + R + EA Sbjct: 2513 IEQEKAKLEQLFQDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEA--- 2566 Query: 86 RELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEELVN 145 EE R ++ E++QL E ++RQ ++LL E + Q + L+ Q L Sbjct: 2567 -------EEGVRRKQEELQQL----EQQRRQQEELLAEENQRLREQLQLLEEQHRAAL-- 2613 Query: 146 RGHCSRPGASEVSAAQ 161 H AS+V+A + Sbjct: 2614 -AHSEEVTASQVAATK 2628 Score = 37.7 bits (86), Expect = 0.092 Identities = 34/124 (27%), Positives = 55/124 (44%), Gaps = 34/124 (27%) Query: 103 IRQLLRWKEAEQRQLQQLLHRERDGVV------------------------RQARELQRQ 138 I + LR E E+R +Q ER+ + R+A+ELQ++ Sbjct: 1341 ISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR 1400 Query: 139 LAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAA----LEV 194 + EE+V R + V A Q + +QE L QLR ++ E A+ R +AA L + Sbjct: 1401 MQEEVVRREEAA------VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1454 Query: 195 ERQL 198 E ++ Sbjct: 1455 EEEI 1458 Score = 37.7 bits (86), Expect = 0.092 Identities = 58/251 (23%), Positives = 109/251 (43%), Gaps = 42/251 (16%) Query: 393 TLQAENKQLRRAGCPYQADEKVKRLKVKRAELTGL-------ARRLADRARKLQETNLRA 445 TL+AE ++ + + +RLK++ AE++ A+R +A ++ E R Sbjct: 2371 TLEAERQR------QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2424 Query: 446 VSAPIPGESCAGLELCQVFARQRARDLSEQASAPLAKDKQIEELRQECHLLQARVASGPC 505 A E ++ ++ +Q D A +++ E+L+QE LLQ + Sbjct: 2425 ELAT--QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK-----S 2477 Query: 506 SDLHTGRGGPCTQWLNVRDLDRLQRE--SQREVLRLQRQLMLQQGNGGAWPEAGGQSATC 563 ++ T + Q +++ LQ+ S+++ L LQR+ ++Q + A Sbjct: 2478 EEMQTVQ-----QEQLLQETQALQQSFLSEKDSL-LQRERFIEQEKAKLEQLFQDEVAKA 2531 Query: 564 EEVRRQMLALERELDQRRRECQELGAQAAPARRRGEEAETQL-----------QAALLKN 612 +++R + +++++Q R Q L A ARRR EAE + Q + Sbjct: 2532 QQLREEQQRQQQQMEQER---QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE 2588 Query: 613 AWLAEENGRLQ 623 LAEEN RL+ Sbjct: 2589 ELLAEENQRLR 2599 Score = 37.7 bits (86), Expect = 0.092 Identities = 38/136 (27%), Positives = 71/136 (52%), Gaps = 16/136 (11%) Query: 26 LENQRRE----LEKLR---AELEAERAGWRAERRRFAARERQLR----EEAERERRQLAD 74 LE QR++ E+LR AELE E+ + E + + +++ E+ +E + L Sbjct: 2438 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2497 Query: 75 RLRSKWEA--QRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQA 132 S+ ++ QR R + Q + ++++ + E+ + + +E +QRQ QQ + +ER +V Sbjct: 2498 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ-QQQMEQERQRLVASM 2556 Query: 133 RELQRQL--AEELVNR 146 E +R+ AEE V R Sbjct: 2557 EEARRRQHEAEEGVRR 2572 Score = 36.6 bits (83), Expect = 0.21 Identities = 55/186 (29%), Positives = 82/186 (44%), Gaps = 23/186 (12%) Query: 23 AAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERE--RRQLADR--LRS 78 AA Q E E+L+ E E+A RA+ + A +LR+EAE+E RR A++ LR Sbjct: 2108 AAQSRRQVEEAERLKQSAE-EQAQARAQAQ---AAAEKLRKEAEQEAARRAQAEQAALRQ 2163 Query: 79 KWEAQRSRELRQLQEEMQREREAEIRQ---LLRWKEAEQRQLQQLLHRERDGVVRQAREL 135 K A E + E ++A++ Q LR + E + LL E + +A E Sbjct: 2164 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2223 Query: 136 QR---QLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAAL 192 R Q+ EEL + R E+S + R + LR D Q R+LQ Sbjct: 2224 ARQRSQVEEELFS----VRVQMEELSKLKARIEAENRALILR-DKDNTQ----RFLQEEA 2274 Query: 193 EVERQL 198 E +Q+ Sbjct: 2275 EKMKQV 2280 Score = 33.1 bits (74), Expect = 2.3 Identities = 34/121 (28%), Positives = 52/121 (42%), Gaps = 12/121 (9%) Query: 22 AAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLR------EEAERERRQLADR 75 A + E Q+R+ +++ E + A RRR E +R ++ E++RRQ + Sbjct: 2531 AQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL 2590 Query: 76 LRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQAREL 135 L E QR RE QL EE R A ++ A Q + L RD + A E Sbjct: 2591 LAE--ENQRLREQLQLLEEQHRAALAHSEEV----TASQVAATKTLPNGRDALDGPAAEA 2644 Query: 136 Q 136 + Sbjct: 2645 E 2645 Score = 31.2 bits (69), Expect = 8.6 Identities = 64/283 (22%), Positives = 112/283 (39%), Gaps = 49/283 (17%) Query: 399 KQLRRAGCPYQADEKVKRLKVKRAELTGLARRLADRARKLQETNLRAVSAPIPGESCAGL 458 ++LR A + +++ + + K +L + + + LQET +A+ E + L Sbjct: 2450 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQET--QALQQSFLSEKDSLL 2507 Query: 459 ELCQVFARQRARDLSEQASAPLAKDKQI--EELRQECHLLQAR---VASGPCSDLHTGRG 513 + + +++A+ L + +AK +Q+ E+ RQ+ + Q R VAS Sbjct: 2508 QRERFIEQEKAK-LEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVAS----------- 2555 Query: 514 GPCTQWLNVRDLDRLQRESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRRQMLAL 573 + + R Q E++ V R Q +L E+ RRQ L Sbjct: 2556 --------MEEARRRQHEAEEGVRRKQEELQ-----------------QLEQQRRQQEEL 2590 Query: 574 ERELDQRRRECQELGAQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVE 633 E +QR RE +L + A E T Q A K NGR A + E Sbjct: 2591 LAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTL----PNGR-DALDGPAAEAE 2645 Query: 634 AENSEVRGHLGRACQERDASGLIAEQLLQQAARGQDRQQQLQR 676 E+S + Q +G+++ + LQ+ A+G +L R Sbjct: 2646 PEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELAR 2688 >gi|41322919 plectin 1 isoform 8 [Homo sapiens] Length = 4547 Score = 73.6 bits (179), Expect = 2e-12 Identities = 206/881 (23%), Positives = 337/881 (38%), Gaps = 164/881 (18%) Query: 25 VLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQ------------- 71 V+ Q E+ R E E RA A++RQ +EEAER RRQ Sbjct: 1456 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1515 Query: 72 -LADRLRSKWEAQRSR--------ELR-QLQEEMQREREAEI---RQLLRWKEAEQRQLQ 118 LA R++++ EA R + ELR Q +E +R R+AE+ RQ+ E QR + Sbjct: 1516 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1575 Query: 119 QLLHRERDGVVRQARELQRQLAEELVN----RGHCSRPGASEVSAAQCRCRLQEVLAQLR 174 L +R + +L+R L EE V R R + A + R + L R Sbjct: 1576 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE--R 1633 Query: 175 WQTDGEQAARIRYLQAALEVERQLFLKYILAHFRGHPA-----LSGSPDPQAVHSLE--- 226 WQ +A R+R LQA EV +Q L A + A G + QAV E Sbjct: 1634 WQLKANEALRLR-LQAE-EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1691 Query: 227 ---EPLPQTSSGSCHAPKPACQLGSLDSLSAEVGVRSRSL------GLVSSACSSSP--- 274 E Q + G+ A Q E G + R L L A +++ Sbjct: 1692 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ 1751 Query: 275 --DGLLSTHASSLDCFAPACSRSLDSTRSLPKASKSEERPSSPDTSTPGSRRLSPPPSPL 332 + L+ + ++ + +R+ + +RS + SK + R L+ + L Sbjct: 1752 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR-----LEAEAGRFRELAEEAARL 1806 Query: 333 PPPPPPSAHRKLSNPRGGEGSESQPCEVLTPSPPGLGHHELIKLNWLLA----KALWVLA 388 + ++ ++ VL +G +K +A +A Sbjct: 1807 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 1866 Query: 389 RRCYTLQA-ENKQLRRAGCPYQADEKVKRLKVKRAELTGLARR--LAD---RARKLQETN 442 RR +A + ++L ++AD + + ++++A + L R+ L + R R+ E Sbjct: 1867 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1926 Query: 443 LRAVSAPIPGESC--AGLELCQVFARQRARDL---SEQASAPLAKDKQI----EELRQEC 493 + A+ A + A LEL R A D EQA A+ +Q+ E R+E Sbjct: 1927 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 1986 Query: 494 HLLQARVASGPCSDLHTGRGGPCTQWLNVRDLDRL-------QRESQREVLRLQRQLMLQ 546 + RV ++ R + +++RL +R +R RQL L Sbjct: 1987 ---EERVQKSLAAEEEAARQRKAA----LEEVERLKAKVEEARRLRERAEQESARQLQLA 2039 Query: 547 QGNGGAWPEAGGQSATCEE------VRRQMLALERELDQRRRECQELGAQAAPARRRGEE 600 Q EA + EE V+++ L++ L Q + +L +A ARR EE Sbjct: 2040 Q-------EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2092 Query: 601 AE--------------------------TQLQAALLKNAWLAEENGRLQAKTDWVRKVEA 634 AE + QA A A E R +A+ + R+ +A Sbjct: 2093 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA 2152 Query: 635 ENSEVRGHLGRACQERDASGLIAEQLLQQAARGQD-----RQQQLQRDPQKALCDLHPSW 689 E + +R A E + AEQ L+Q A+ + R Q + D QK L D Sbjct: 2153 EQAALR-QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD----- 2206 Query: 690 KEIQALQCRPGHPPEQPWETSQMPES------QVKGSRRPKFHARPEDYAVSQPNRD--- 740 +E+Q L+ E + SQ+ E Q++ + K E+ A+ ++D Sbjct: 2207 EELQRLK---AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ 2263 Query: 741 --IQEKREASLEES------PVALGESASVPQVSETVPASQ 773 +QE+ E + + VA E+A + Q++E A Q Sbjct: 2264 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2304 Score = 58.2 bits (139), Expect = 7e-08 Identities = 175/803 (21%), Positives = 304/803 (37%), Gaps = 77/803 (9%) Query: 34 EKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSRELRQLQE 93 E LR E ER AE++R RER EA E+++ ++ +AQ RE ++LQ+ Sbjct: 1339 ETLRRMEEEERL---AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1395 Query: 94 EMQRE---RE---AEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQR---QLAEE-- 142 MQ E RE + +Q R + E +QL+Q E RQA +R ++ EE Sbjct: 1396 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1455 Query: 143 ---LVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAALEVERQLF 199 L + G +E R R +E AQ R E+A R+R Q E +R+ Sbjct: 1456 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQ--EEAERLR-RQVQDESQRKRQ 1512 Query: 200 LKYILAHFRGHPALSGSPDPQAVHSLEEPLPQTSSGSCHAPKPACQLGSLDSLSAEVGVR 259 + LA A + +A+ +LEE Q + + ++ E R Sbjct: 1513 AEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1572 Query: 260 SRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTRSLPKASKSEERPSSP---- 315 S L S S + + + A A R R+ +A R + Sbjct: 1573 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1632 Query: 316 ----DTSTPGSRRLSPPPSPLPPPPPPSAHRKLSNPRGGEGSESQPCEVLTPSPPGLGHH 371 + RL + K E E L Sbjct: 1633 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1692 Query: 372 ELIKLNWL--------LAKALWVLARRCYTLQAENK-----------QLRRAGCPYQADE 412 EL K L LA ++ R T Q E + Q A + E Sbjct: 1693 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1752 Query: 413 KVKRLKVKRAELTGLARRLADRARKLQETNLRAVSAPIPGESCAG--LELCQVFARQRAR 470 L RAE+ L LA +AR +E+ + + E+ AG EL + AR RA Sbjct: 1753 LEAELAKVRAEMEVL---LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1809 Query: 471 DLSEQASAPLAKDKQIEELRQECHLLQARVAS-GPCSDLHTGRGGPCTQWLNVRDLDRLQ 529 + LA++ + + +L ++A+ G + L T + + +RL+ Sbjct: 1810 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE--KEAENERLR 1867 Query: 530 RESQREVLRLQRQLMLQQGNGGAWPE---AGGQSATCEEVRRQMLALERELDQRRRECQE 586 R ++ E + +R+L Q A E A + A+ E+ RQ +E L QRR+ +E Sbjct: 1868 RLAEDEAFQ-RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1926 Query: 587 -LGAQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLGR 645 L +A+ + +AE +L+ +++ + QA+ + R+ + E R R Sbjct: 1927 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR--R 1984 Query: 646 ACQERDASGLIAEQLLQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQALQCRPGHPPEQ 705 +ER L AE+ + A + + ++++R L +E + L+ R + Sbjct: 1985 EAEERVQKSLAAEE--EAARQRKAALEEVER--------LKAKVEEARRLRER-----AE 2029 Query: 706 PWETSQMPESQVKGSRRPKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQV 765 Q+ +Q +R + + +AV Q +++Q+ + GE+ + + Sbjct: 2030 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2089 Query: 766 SETVPASQPLSKKTSSQSNSSSE 788 +E ++ +++ ++QS E Sbjct: 2090 AEEAEEARVQAEREAAQSRRQVE 2112 Score = 54.3 bits (129), Expect = 1e-06 Identities = 59/188 (31%), Positives = 89/188 (47%), Gaps = 24/188 (12%) Query: 23 AAVLENQRRELE-KLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWE 81 AA E +RRE E +++ L AE A R+R AA E R +A+ E A RLR + E Sbjct: 1976 AAEEERRRREAEERVQKSLAAEE---EAARQRKAALEEVERLKAKVEE---ARRLRERAE 2029 Query: 82 AQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGV--VRQARELQRQL 139 + +R+L+ QE Q+ +AE + + ++++LQQ L +E+ + +R E R+ Sbjct: 2030 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2089 Query: 140 AEELVN-RGHCSRPGA--------------SEVSAAQCRCRLQEVLAQLRWQTDGEQAAR 184 AEE R R A S AQ R + Q +LR + + E A R Sbjct: 2090 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2149 Query: 185 IRYLQAAL 192 + QAAL Sbjct: 2150 AQAEQAAL 2157 Score = 50.8 bits (120), Expect = 1e-05 Identities = 52/191 (27%), Positives = 96/191 (50%), Gaps = 23/191 (12%) Query: 24 AVLENQRRELEKLR-AELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEA 82 +VL+ R E E R A EAE A +AER AA+ R+ EEAER ++ ++ +++ +A Sbjct: 2074 SVLDQLRGEAEAARRAAEEAEEARVQAERE--AAQSRRQVEEAERLKQSAEEQAQARAQA 2131 Query: 83 QRSRELRQLQEEMQREREAEIRQ-LLRWKEAEQRQLQQLLHRE-RDGVVRQARELQRQLA 140 Q + E + + E + R A+ Q LR K+A ++++ H++ + +RQ +++++L Sbjct: 2132 QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK--HKKFAEQTLRQKAQVEQELT 2189 Query: 141 E---ELVNRGH--------CSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQ 189 +L H R A AA+ R +++E L +R Q + + L+ Sbjct: 2190 TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME-----ELSKLK 2244 Query: 190 AALEVERQLFL 200 A +E E + + Sbjct: 2245 ARIEAENRALI 2255 Score = 49.3 bits (116), Expect = 3e-05 Identities = 56/186 (30%), Positives = 89/186 (47%), Gaps = 20/186 (10%) Query: 29 QRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSREL 88 Q EL KL+A +EAE + +R L+EEAE+ ++ + R AQ + L Sbjct: 2236 QMEELSKLKARIEAENRALILRDKDNT--QRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2293 Query: 89 RQLQEEMQREREAEIRQLLRWK-----EAEQRQLQ-QLLHRERDGVVRQARELQ------ 136 RQL EE ++ A ++L+ K EA + + + +LL ++++ QAR LQ Sbjct: 2294 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2353 Query: 137 -RQLAEE---LVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAAL 192 +QLAEE R E+SA R +L+ V R Q E+ A+ R+ + A Sbjct: 2354 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR-VAEMSRAQARAEEDAQ-RFRKQAE 2411 Query: 193 EVERQL 198 E+ +L Sbjct: 2412 EIGEKL 2417 Score = 47.4 bits (111), Expect = 1e-04 Identities = 56/204 (27%), Positives = 81/204 (39%), Gaps = 46/204 (22%) Query: 24 AVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQ 83 A L+ + + R ELEAE A RAE A + AE E R +++ + + EA+ Sbjct: 1737 ARLQREAAAATQKRQELEAELAKVRAEMEVLLAS----KARAEEESRSTSEKSKQRLEAE 1792 Query: 84 RSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEEL 143 R R+L EE R R L + QRQL + + RQ E +R LAE+L Sbjct: 1793 AGR-FRELAEEAARLR------ALAEEAKRQRQLAE------EDAARQRAEAERVLAEKL 1839 Query: 144 VNRGHCSRPGAS-----------------------------EVSAAQCRCRLQEVLAQLR 174 G +R E AAQ + ++E LAQLR Sbjct: 1840 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1899 Query: 175 WQTDGEQAARIRYLQAALEVERQL 198 +D E + ++ L RQ+ Sbjct: 1900 KASDSELERQKGLVEDTLRQRRQV 1923 Score = 46.6 bits (109), Expect = 2e-04 Identities = 58/189 (30%), Positives = 90/189 (47%), Gaps = 36/189 (19%) Query: 32 ELEKLRAEL-EAERAGWRAERRRFAARER-----QLREEAERERRQLADRLRSKWEAQR- 84 EL++L+AE EA R + E F+ R + +L+ E E R L LR K QR Sbjct: 2208 ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI--LRDKDNTQRF 2265 Query: 85 ----SRELRQLQEEMQR-----EREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQAREL 135 + +++Q+ EE R + A +RQL A+QR L + + +E+ V++A L Sbjct: 2266 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2325 Query: 136 QRQLAEELVNRGHCSRPGASEVSAAQCRCRLQE----VLAQLRWQTDGEQ----AARIRY 187 + + EL+ + E++ Q R RLQE + QL +T G Q A R R Sbjct: 2326 KAE--AELLQQ-------QKELAQEQAR-RLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2375 Query: 188 LQAALEVER 196 L+ + E ER Sbjct: 2376 LEMSAEAER 2384 Score = 44.7 bits (104), Expect = 8e-04 Identities = 62/184 (33%), Positives = 86/184 (46%), Gaps = 15/184 (8%) Query: 22 AAAVLENQR--RELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSK 79 A A E QR + LE+LR L+AE A R R+ R RQ++ E +R L+SK Sbjct: 1525 AEAAREKQRALQALEELR--LQAEEAE-RRLRQAEVERARQVQVALETAQRSAEAELQSK 1581 Query: 80 WEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQL-LHRERDGVVRQARELQRQ 138 A + + QL+ +Q E A + QL +EAE+R QQ R R+ R+ Q + Sbjct: 1582 -RASFAEKTAQLERSLQEEHVA-VAQLR--EEAERRAQQQAEAERAREEAERELERWQLK 1637 Query: 139 LAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDG---EQAARIRYL-QAALEV 194 E L R A + S AQ Q+ A+ + G EQA R R L + LE Sbjct: 1638 ANEALRLRLQAEEV-AQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK 1696 Query: 195 ERQL 198 +RQL Sbjct: 1697 QRQL 1700 Score = 44.7 bits (104), Expect = 8e-04 Identities = 33/122 (27%), Positives = 67/122 (54%), Gaps = 11/122 (9%) Query: 40 LEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSRELRQLQEEMQRER 99 +E E+A + A+ +QLREE +R+++Q+ E +R R + ++E +R+ Sbjct: 2509 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM--------EQERQRLVASMEEARRRQH 2560 Query: 100 EAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEELVNRGHCSRPGASEVSA 159 EAE + +R K+ E +QL+Q ++ + + + + L+ QL + L + + + EV+A Sbjct: 2561 EAE--EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL-QLLEEQHRAALAHSEEVTA 2617 Query: 160 AQ 161 +Q Sbjct: 2618 SQ 2619 Score = 41.2 bits (95), Expect = 0.008 Identities = 34/125 (27%), Positives = 61/125 (48%), Gaps = 20/125 (16%) Query: 30 RRELEKLRAELEAERAGWRAERRRFAARER------------QLREEAERERRQLADRLR 77 R E + R +AE G + R A +E+ Q +AER R +A+ R Sbjct: 2398 RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER 2457 Query: 78 SKWEAQRSRELRQLQ-EEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQ 136 K + Q+ +L QL+ EEMQ ++ ++ Q E + LQQ E+D ++++ R ++ Sbjct: 2458 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQ-------ETQALQQSFLSEKDSLLQRERFIE 2510 Query: 137 RQLAE 141 ++ A+ Sbjct: 2511 QEKAK 2515 Score = 40.4 bits (93), Expect = 0.014 Identities = 40/140 (28%), Positives = 65/140 (46%), Gaps = 20/140 (14%) Query: 26 LENQRRELEKLRAELEAERAGWRAER----------RRFAARERQLREEAERERRQLADR 75 LE + L+KLRA+ EA++ + A R R R + E ER R ++A + Sbjct: 1125 LEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA-Q 1183 Query: 76 LRSKWEA------QRSRELRQLQEEMQREREA--EIRQLLRWKEAEQRQLQQLLHRERDG 127 L +W+A R REL QL +++ RE+ + L+ Q Q+Q + + Sbjct: 1184 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1243 Query: 128 VVRQARELQRQLAEELVNRG 147 V Q R+ ++ L EE+ G Sbjct: 1244 VREQLRQ-EQALLEEIERHG 1262 Score = 39.7 bits (91), Expect = 0.024 Identities = 42/174 (24%), Positives = 72/174 (41%), Gaps = 7/174 (4%) Query: 24 AVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQ 83 A +E R+ L + A +++R FA + QL + E +A +LR EA+ Sbjct: 1555 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVA-QLRE--EAE 1611 Query: 84 RSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEEL 143 R Q Q E +R RE R+L RW+ L+ L E + + + + +E Sbjct: 1612 RRA---QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1668 Query: 144 VNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAALEVERQ 197 R R G +E A + R ++ L + R +G R+ Q + + + Sbjct: 1669 AER-EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE 1721 Score = 39.7 bits (91), Expect = 0.024 Identities = 53/186 (28%), Positives = 84/186 (45%), Gaps = 16/186 (8%) Query: 23 AAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWE- 81 AA L +E +LR E + A RA + + Q +EA R + + A+ L+ + E Sbjct: 2280 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE-AELLQQQKEL 2338 Query: 82 -AQRSRELRQLQEEMQREREAEIRQLLRWKEAE-QRQLQQLLHRERDGVVRQARELQRQL 139 +++R L++ +E+M ++ E + R EAE QRQL+ ER + + Sbjct: 2339 AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2398 Query: 140 AEELVNRGHCSRPGASEVS--------AAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAA 191 AEE R R A E+ A Q + L + L R Q+D A R+R A Sbjct: 2399 AEEDAQR---FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD-HDAERLREAIAE 2454 Query: 192 LEVERQ 197 LE E++ Sbjct: 2455 LEREKE 2460 Score = 38.5 bits (88), Expect = 0.054 Identities = 35/136 (25%), Positives = 67/136 (49%), Gaps = 20/136 (14%) Query: 26 LENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRS 85 +E ++ +LE+L + A+ R E++R +++Q+ +E +R + + R + EA Sbjct: 2509 IEQEKAKLEQLFQDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEA--- 2562 Query: 86 RELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEELVN 145 EE R ++ E++QL E ++RQ ++LL E + Q + L+ Q L Sbjct: 2563 -------EEGVRRKQEELQQL----EQQRRQQEELLAEENQRLREQLQLLEEQHRAAL-- 2609 Query: 146 RGHCSRPGASEVSAAQ 161 H AS+V+A + Sbjct: 2610 -AHSEEVTASQVAATK 2624 Score = 37.7 bits (86), Expect = 0.092 Identities = 34/124 (27%), Positives = 55/124 (44%), Gaps = 34/124 (27%) Query: 103 IRQLLRWKEAEQRQLQQLLHRERDGVV------------------------RQARELQRQ 138 I + LR E E+R +Q ER+ + R+A+ELQ++ Sbjct: 1337 ISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR 1396 Query: 139 LAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAA----LEV 194 + EE+V R + V A Q + +QE L QLR ++ E A+ R +AA L + Sbjct: 1397 MQEEVVRREEAA------VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1450 Query: 195 ERQL 198 E ++ Sbjct: 1451 EEEI 1454 Score = 37.7 bits (86), Expect = 0.092 Identities = 58/251 (23%), Positives = 109/251 (43%), Gaps = 42/251 (16%) Query: 393 TLQAENKQLRRAGCPYQADEKVKRLKVKRAELTGL-------ARRLADRARKLQETNLRA 445 TL+AE ++ + + +RLK++ AE++ A+R +A ++ E R Sbjct: 2367 TLEAERQR------QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2420 Query: 446 VSAPIPGESCAGLELCQVFARQRARDLSEQASAPLAKDKQIEELRQECHLLQARVASGPC 505 A E ++ ++ +Q D A +++ E+L+QE LLQ + Sbjct: 2421 ELAT--QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK-----S 2473 Query: 506 SDLHTGRGGPCTQWLNVRDLDRLQRE--SQREVLRLQRQLMLQQGNGGAWPEAGGQSATC 563 ++ T + Q +++ LQ+ S+++ L LQR+ ++Q + A Sbjct: 2474 EEMQTVQ-----QEQLLQETQALQQSFLSEKDSL-LQRERFIEQEKAKLEQLFQDEVAKA 2527 Query: 564 EEVRRQMLALERELDQRRRECQELGAQAAPARRRGEEAETQL-----------QAALLKN 612 +++R + +++++Q R Q L A ARRR EAE + Q + Sbjct: 2528 QQLREEQQRQQQQMEQER---QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE 2584 Query: 613 AWLAEENGRLQ 623 LAEEN RL+ Sbjct: 2585 ELLAEENQRLR 2595 Score = 37.7 bits (86), Expect = 0.092 Identities = 38/136 (27%), Positives = 71/136 (52%), Gaps = 16/136 (11%) Query: 26 LENQRRE----LEKLR---AELEAERAGWRAERRRFAARERQLR----EEAERERRQLAD 74 LE QR++ E+LR AELE E+ + E + + +++ E+ +E + L Sbjct: 2434 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2493 Query: 75 RLRSKWEA--QRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQA 132 S+ ++ QR R + Q + ++++ + E+ + + +E +QRQ QQ + +ER +V Sbjct: 2494 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ-QQQMEQERQRLVASM 2552 Query: 133 RELQRQL--AEELVNR 146 E +R+ AEE V R Sbjct: 2553 EEARRRQHEAEEGVRR 2568 Score = 36.6 bits (83), Expect = 0.21 Identities = 55/186 (29%), Positives = 82/186 (44%), Gaps = 23/186 (12%) Query: 23 AAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERE--RRQLADR--LRS 78 AA Q E E+L+ E E+A RA+ + A +LR+EAE+E RR A++ LR Sbjct: 2104 AAQSRRQVEEAERLKQSAE-EQAQARAQAQ---AAAEKLRKEAEQEAARRAQAEQAALRQ 2159 Query: 79 KWEAQRSRELRQLQEEMQREREAEIRQ---LLRWKEAEQRQLQQLLHRERDGVVRQAREL 135 K A E + E ++A++ Q LR + E + LL E + +A E Sbjct: 2160 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2219 Query: 136 QR---QLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAAL 192 R Q+ EEL + R E+S + R + LR D Q R+LQ Sbjct: 2220 ARQRSQVEEELFS----VRVQMEELSKLKARIEAENRALILR-DKDNTQ----RFLQEEA 2270 Query: 193 EVERQL 198 E +Q+ Sbjct: 2271 EKMKQV 2276 Score = 33.1 bits (74), Expect = 2.3 Identities = 34/121 (28%), Positives = 52/121 (42%), Gaps = 12/121 (9%) Query: 22 AAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLR------EEAERERRQLADR 75 A + E Q+R+ +++ E + A RRR E +R ++ E++RRQ + Sbjct: 2527 AQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL 2586 Query: 76 LRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQAREL 135 L E QR RE QL EE R A ++ A Q + L RD + A E Sbjct: 2587 LAE--ENQRLREQLQLLEEQHRAALAHSEEV----TASQVAATKTLPNGRDALDGPAAEA 2640 Query: 136 Q 136 + Sbjct: 2641 E 2641 Score = 31.2 bits (69), Expect = 8.6 Identities = 64/283 (22%), Positives = 112/283 (39%), Gaps = 49/283 (17%) Query: 399 KQLRRAGCPYQADEKVKRLKVKRAELTGLARRLADRARKLQETNLRAVSAPIPGESCAGL 458 ++LR A + +++ + + K +L + + + LQET +A+ E + L Sbjct: 2446 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQET--QALQQSFLSEKDSLL 2503 Query: 459 ELCQVFARQRARDLSEQASAPLAKDKQI--EELRQECHLLQAR---VASGPCSDLHTGRG 513 + + +++A+ L + +AK +Q+ E+ RQ+ + Q R VAS Sbjct: 2504 QRERFIEQEKAK-LEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVAS----------- 2551 Query: 514 GPCTQWLNVRDLDRLQRESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRRQMLAL 573 + + R Q E++ V R Q +L E+ RRQ L Sbjct: 2552 --------MEEARRRQHEAEEGVRRKQEELQ-----------------QLEQQRRQQEEL 2586 Query: 574 ERELDQRRRECQELGAQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVE 633 E +QR RE +L + A E T Q A K NGR A + E Sbjct: 2587 LAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTL----PNGR-DALDGPAAEAE 2641 Query: 634 AENSEVRGHLGRACQERDASGLIAEQLLQQAARGQDRQQQLQR 676 E+S + Q +G+++ + LQ+ A+G +L R Sbjct: 2642 PEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELAR 2684 >gi|41322910 plectin 1 isoform 7 [Homo sapiens] Length = 4515 Score = 73.6 bits (179), Expect = 2e-12 Identities = 206/881 (23%), Positives = 337/881 (38%), Gaps = 164/881 (18%) Query: 25 VLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQ------------- 71 V+ Q E+ R E E RA A++RQ +EEAER RRQ Sbjct: 1424 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1483 Query: 72 -LADRLRSKWEAQRSR--------ELR-QLQEEMQREREAEI---RQLLRWKEAEQRQLQ 118 LA R++++ EA R + ELR Q +E +R R+AE+ RQ+ E QR + Sbjct: 1484 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1543 Query: 119 QLLHRERDGVVRQARELQRQLAEELVN----RGHCSRPGASEVSAAQCRCRLQEVLAQLR 174 L +R + +L+R L EE V R R + A + R + L R Sbjct: 1544 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE--R 1601 Query: 175 WQTDGEQAARIRYLQAALEVERQLFLKYILAHFRGHPA-----LSGSPDPQAVHSLE--- 226 WQ +A R+R LQA EV +Q L A + A G + QAV E Sbjct: 1602 WQLKANEALRLR-LQAE-EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1659 Query: 227 ---EPLPQTSSGSCHAPKPACQLGSLDSLSAEVGVRSRSL------GLVSSACSSSP--- 274 E Q + G+ A Q E G + R L L A +++ Sbjct: 1660 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ 1719 Query: 275 --DGLLSTHASSLDCFAPACSRSLDSTRSLPKASKSEERPSSPDTSTPGSRRLSPPPSPL 332 + L+ + ++ + +R+ + +RS + SK + R L+ + L Sbjct: 1720 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR-----LEAEAGRFRELAEEAARL 1774 Query: 333 PPPPPPSAHRKLSNPRGGEGSESQPCEVLTPSPPGLGHHELIKLNWLLA----KALWVLA 388 + ++ ++ VL +G +K +A +A Sbjct: 1775 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 1834 Query: 389 RRCYTLQA-ENKQLRRAGCPYQADEKVKRLKVKRAELTGLARR--LAD---RARKLQETN 442 RR +A + ++L ++AD + + ++++A + L R+ L + R R+ E Sbjct: 1835 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1894 Query: 443 LRAVSAPIPGESC--AGLELCQVFARQRARDL---SEQASAPLAKDKQI----EELRQEC 493 + A+ A + A LEL R A D EQA A+ +Q+ E R+E Sbjct: 1895 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 1954 Query: 494 HLLQARVASGPCSDLHTGRGGPCTQWLNVRDLDRL-------QRESQREVLRLQRQLMLQ 546 + RV ++ R + +++RL +R +R RQL L Sbjct: 1955 ---EERVQKSLAAEEEAARQRKAA----LEEVERLKAKVEEARRLRERAEQESARQLQLA 2007 Query: 547 QGNGGAWPEAGGQSATCEE------VRRQMLALERELDQRRRECQELGAQAAPARRRGEE 600 Q EA + EE V+++ L++ L Q + +L +A ARR EE Sbjct: 2008 Q-------EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2060 Query: 601 AE--------------------------TQLQAALLKNAWLAEENGRLQAKTDWVRKVEA 634 AE + QA A A E R +A+ + R+ +A Sbjct: 2061 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA 2120 Query: 635 ENSEVRGHLGRACQERDASGLIAEQLLQQAARGQD-----RQQQLQRDPQKALCDLHPSW 689 E + +R A E + AEQ L+Q A+ + R Q + D QK L D Sbjct: 2121 EQAALR-QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD----- 2174 Query: 690 KEIQALQCRPGHPPEQPWETSQMPES------QVKGSRRPKFHARPEDYAVSQPNRD--- 740 +E+Q L+ E + SQ+ E Q++ + K E+ A+ ++D Sbjct: 2175 EELQRLK---AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ 2231 Query: 741 --IQEKREASLEES------PVALGESASVPQVSETVPASQ 773 +QE+ E + + VA E+A + Q++E A Q Sbjct: 2232 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2272 Score = 58.2 bits (139), Expect = 7e-08 Identities = 175/803 (21%), Positives = 304/803 (37%), Gaps = 77/803 (9%) Query: 34 EKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSRELRQLQE 93 E LR E ER AE++R RER EA E+++ ++ +AQ RE ++LQ+ Sbjct: 1307 ETLRRMEEEERL---AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1363 Query: 94 EMQRE---RE---AEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQR---QLAEE-- 142 MQ E RE + +Q R + E +QL+Q E RQA +R ++ EE Sbjct: 1364 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1423 Query: 143 ---LVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAALEVERQLF 199 L + G +E R R +E AQ R E+A R+R Q E +R+ Sbjct: 1424 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQ--EEAERLR-RQVQDESQRKRQ 1480 Query: 200 LKYILAHFRGHPALSGSPDPQAVHSLEEPLPQTSSGSCHAPKPACQLGSLDSLSAEVGVR 259 + LA A + +A+ +LEE Q + + ++ E R Sbjct: 1481 AEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1540 Query: 260 SRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTRSLPKASKSEERPSSP---- 315 S L S S + + + A A R R+ +A R + Sbjct: 1541 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1600 Query: 316 ----DTSTPGSRRLSPPPSPLPPPPPPSAHRKLSNPRGGEGSESQPCEVLTPSPPGLGHH 371 + RL + K E E L Sbjct: 1601 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1660 Query: 372 ELIKLNWL--------LAKALWVLARRCYTLQAENK-----------QLRRAGCPYQADE 412 EL K L LA ++ R T Q E + Q A + E Sbjct: 1661 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1720 Query: 413 KVKRLKVKRAELTGLARRLADRARKLQETNLRAVSAPIPGESCAG--LELCQVFARQRAR 470 L RAE+ L LA +AR +E+ + + E+ AG EL + AR RA Sbjct: 1721 LEAELAKVRAEMEVL---LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1777 Query: 471 DLSEQASAPLAKDKQIEELRQECHLLQARVAS-GPCSDLHTGRGGPCTQWLNVRDLDRLQ 529 + LA++ + + +L ++A+ G + L T + + +RL+ Sbjct: 1778 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE--KEAENERLR 1835 Query: 530 RESQREVLRLQRQLMLQQGNGGAWPE---AGGQSATCEEVRRQMLALERELDQRRRECQE 586 R ++ E + +R+L Q A E A + A+ E+ RQ +E L QRR+ +E Sbjct: 1836 RLAEDEAFQ-RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1894 Query: 587 -LGAQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLGR 645 L +A+ + +AE +L+ +++ + QA+ + R+ + E R R Sbjct: 1895 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR--R 1952 Query: 646 ACQERDASGLIAEQLLQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQALQCRPGHPPEQ 705 +ER L AE+ + A + + ++++R L +E + L+ R + Sbjct: 1953 EAEERVQKSLAAEE--EAARQRKAALEEVER--------LKAKVEEARRLRER-----AE 1997 Query: 706 PWETSQMPESQVKGSRRPKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQV 765 Q+ +Q +R + + +AV Q +++Q+ + GE+ + + Sbjct: 1998 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2057 Query: 766 SETVPASQPLSKKTSSQSNSSSE 788 +E ++ +++ ++QS E Sbjct: 2058 AEEAEEARVQAEREAAQSRRQVE 2080 Score = 54.3 bits (129), Expect = 1e-06 Identities = 59/188 (31%), Positives = 89/188 (47%), Gaps = 24/188 (12%) Query: 23 AAVLENQRRELE-KLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWE 81 AA E +RRE E +++ L AE A R+R AA E R +A+ E A RLR + E Sbjct: 1944 AAEEERRRREAEERVQKSLAAEE---EAARQRKAALEEVERLKAKVEE---ARRLRERAE 1997 Query: 82 AQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGV--VRQARELQRQL 139 + +R+L+ QE Q+ +AE + + ++++LQQ L +E+ + +R E R+ Sbjct: 1998 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2057 Query: 140 AEELVN-RGHCSRPGA--------------SEVSAAQCRCRLQEVLAQLRWQTDGEQAAR 184 AEE R R A S AQ R + Q +LR + + E A R Sbjct: 2058 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2117 Query: 185 IRYLQAAL 192 + QAAL Sbjct: 2118 AQAEQAAL 2125 Score = 50.8 bits (120), Expect = 1e-05 Identities = 52/191 (27%), Positives = 96/191 (50%), Gaps = 23/191 (12%) Query: 24 AVLENQRRELEKLR-AELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEA 82 +VL+ R E E R A EAE A +AER AA+ R+ EEAER ++ ++ +++ +A Sbjct: 2042 SVLDQLRGEAEAARRAAEEAEEARVQAERE--AAQSRRQVEEAERLKQSAEEQAQARAQA 2099 Query: 83 QRSRELRQLQEEMQREREAEIRQ-LLRWKEAEQRQLQQLLHRE-RDGVVRQARELQRQLA 140 Q + E + + E + R A+ Q LR K+A ++++ H++ + +RQ +++++L Sbjct: 2100 QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK--HKKFAEQTLRQKAQVEQELT 2157 Query: 141 E---ELVNRGH--------CSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQ 189 +L H R A AA+ R +++E L +R Q + + L+ Sbjct: 2158 TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME-----ELSKLK 2212 Query: 190 AALEVERQLFL 200 A +E E + + Sbjct: 2213 ARIEAENRALI 2223 Score = 49.3 bits (116), Expect = 3e-05 Identities = 56/186 (30%), Positives = 89/186 (47%), Gaps = 20/186 (10%) Query: 29 QRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSREL 88 Q EL KL+A +EAE + +R L+EEAE+ ++ + R AQ + L Sbjct: 2204 QMEELSKLKARIEAENRALILRDKDNT--QRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2261 Query: 89 RQLQEEMQREREAEIRQLLRWK-----EAEQRQLQ-QLLHRERDGVVRQARELQ------ 136 RQL EE ++ A ++L+ K EA + + + +LL ++++ QAR LQ Sbjct: 2262 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2321 Query: 137 -RQLAEE---LVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAAL 192 +QLAEE R E+SA R +L+ V R Q E+ A+ R+ + A Sbjct: 2322 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR-VAEMSRAQARAEEDAQ-RFRKQAE 2379 Query: 193 EVERQL 198 E+ +L Sbjct: 2380 EIGEKL 2385 Score = 47.4 bits (111), Expect = 1e-04 Identities = 56/204 (27%), Positives = 81/204 (39%), Gaps = 46/204 (22%) Query: 24 AVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQ 83 A L+ + + R ELEAE A RAE A + AE E R +++ + + EA+ Sbjct: 1705 ARLQREAAAATQKRQELEAELAKVRAEMEVLLAS----KARAEEESRSTSEKSKQRLEAE 1760 Query: 84 RSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEEL 143 R R+L EE R R L + QRQL + + RQ E +R LAE+L Sbjct: 1761 AGR-FRELAEEAARLR------ALAEEAKRQRQLAE------EDAARQRAEAERVLAEKL 1807 Query: 144 VNRGHCSRPGAS-----------------------------EVSAAQCRCRLQEVLAQLR 174 G +R E AAQ + ++E LAQLR Sbjct: 1808 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1867 Query: 175 WQTDGEQAARIRYLQAALEVERQL 198 +D E + ++ L RQ+ Sbjct: 1868 KASDSELERQKGLVEDTLRQRRQV 1891 Score = 46.6 bits (109), Expect = 2e-04 Identities = 58/189 (30%), Positives = 90/189 (47%), Gaps = 36/189 (19%) Query: 32 ELEKLRAEL-EAERAGWRAERRRFAARER-----QLREEAERERRQLADRLRSKWEAQR- 84 EL++L+AE EA R + E F+ R + +L+ E E R L LR K QR Sbjct: 2176 ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI--LRDKDNTQRF 2233 Query: 85 ----SRELRQLQEEMQR-----EREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQAREL 135 + +++Q+ EE R + A +RQL A+QR L + + +E+ V++A L Sbjct: 2234 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2293 Query: 136 QRQLAEELVNRGHCSRPGASEVSAAQCRCRLQE----VLAQLRWQTDGEQ----AARIRY 187 + + EL+ + E++ Q R RLQE + QL +T G Q A R R Sbjct: 2294 KAE--AELLQQ-------QKELAQEQAR-RLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2343 Query: 188 LQAALEVER 196 L+ + E ER Sbjct: 2344 LEMSAEAER 2352 Score = 44.7 bits (104), Expect = 8e-04 Identities = 62/184 (33%), Positives = 86/184 (46%), Gaps = 15/184 (8%) Query: 22 AAAVLENQR--RELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSK 79 A A E QR + LE+LR L+AE A R R+ R RQ++ E +R L+SK Sbjct: 1493 AEAAREKQRALQALEELR--LQAEEAE-RRLRQAEVERARQVQVALETAQRSAEAELQSK 1549 Query: 80 WEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQL-LHRERDGVVRQARELQRQ 138 A + + QL+ +Q E A + QL +EAE+R QQ R R+ R+ Q + Sbjct: 1550 -RASFAEKTAQLERSLQEEHVA-VAQLR--EEAERRAQQQAEAERAREEAERELERWQLK 1605 Query: 139 LAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDG---EQAARIRYL-QAALEV 194 E L R A + S AQ Q+ A+ + G EQA R R L + LE Sbjct: 1606 ANEALRLRLQAEEV-AQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK 1664 Query: 195 ERQL 198 +RQL Sbjct: 1665 QRQL 1668 Score = 44.7 bits (104), Expect = 8e-04 Identities = 33/122 (27%), Positives = 67/122 (54%), Gaps = 11/122 (9%) Query: 40 LEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSRELRQLQEEMQRER 99 +E E+A + A+ +QLREE +R+++Q+ E +R R + ++E +R+ Sbjct: 2477 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM--------EQERQRLVASMEEARRRQH 2528 Query: 100 EAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEELVNRGHCSRPGASEVSA 159 EAE + +R K+ E +QL+Q ++ + + + + L+ QL + L + + + EV+A Sbjct: 2529 EAE--EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL-QLLEEQHRAALAHSEEVTA 2585 Query: 160 AQ 161 +Q Sbjct: 2586 SQ 2587 Score = 41.2 bits (95), Expect = 0.008 Identities = 34/125 (27%), Positives = 61/125 (48%), Gaps = 20/125 (16%) Query: 30 RRELEKLRAELEAERAGWRAERRRFAARER------------QLREEAERERRQLADRLR 77 R E + R +AE G + R A +E+ Q +AER R +A+ R Sbjct: 2366 RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER 2425 Query: 78 SKWEAQRSRELRQLQ-EEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQ 136 K + Q+ +L QL+ EEMQ ++ ++ Q E + LQQ E+D ++++ R ++ Sbjct: 2426 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQ-------ETQALQQSFLSEKDSLLQRERFIE 2478 Query: 137 RQLAE 141 ++ A+ Sbjct: 2479 QEKAK 2483 Score = 40.4 bits (93), Expect = 0.014 Identities = 40/140 (28%), Positives = 65/140 (46%), Gaps = 20/140 (14%) Query: 26 LENQRRELEKLRAELEAERAGWRAER----------RRFAARERQLREEAERERRQLADR 75 LE + L+KLRA+ EA++ + A R R R + E ER R ++A + Sbjct: 1093 LEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA-Q 1151 Query: 76 LRSKWEA------QRSRELRQLQEEMQREREA--EIRQLLRWKEAEQRQLQQLLHRERDG 127 L +W+A R REL QL +++ RE+ + L+ Q Q+Q + + Sbjct: 1152 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1211 Query: 128 VVRQARELQRQLAEELVNRG 147 V Q R+ ++ L EE+ G Sbjct: 1212 VREQLRQ-EQALLEEIERHG 1230 Score = 39.7 bits (91), Expect = 0.024 Identities = 42/174 (24%), Positives = 72/174 (41%), Gaps = 7/174 (4%) Query: 24 AVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQ 83 A +E R+ L + A +++R FA + QL + E +A +LR EA+ Sbjct: 1523 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVA-QLRE--EAE 1579 Query: 84 RSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEEL 143 R Q Q E +R RE R+L RW+ L+ L E + + + + +E Sbjct: 1580 RRA---QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1636 Query: 144 VNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAALEVERQ 197 R R G +E A + R ++ L + R +G R+ Q + + + Sbjct: 1637 AER-EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE 1689 Score = 39.7 bits (91), Expect = 0.024 Identities = 53/186 (28%), Positives = 84/186 (45%), Gaps = 16/186 (8%) Query: 23 AAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWE- 81 AA L +E +LR E + A RA + + Q +EA R + + A+ L+ + E Sbjct: 2248 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE-AELLQQQKEL 2306 Query: 82 -AQRSRELRQLQEEMQREREAEIRQLLRWKEAE-QRQLQQLLHRERDGVVRQARELQRQL 139 +++R L++ +E+M ++ E + R EAE QRQL+ ER + + Sbjct: 2307 AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2366 Query: 140 AEELVNRGHCSRPGASEVS--------AAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAA 191 AEE R R A E+ A Q + L + L R Q+D A R+R A Sbjct: 2367 AEEDAQR---FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD-HDAERLREAIAE 2422 Query: 192 LEVERQ 197 LE E++ Sbjct: 2423 LEREKE 2428 Score = 38.5 bits (88), Expect = 0.054 Identities = 35/136 (25%), Positives = 67/136 (49%), Gaps = 20/136 (14%) Query: 26 LENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRS 85 +E ++ +LE+L + A+ R E++R +++Q+ +E +R + + R + EA Sbjct: 2477 IEQEKAKLEQLFQDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEA--- 2530 Query: 86 RELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEELVN 145 EE R ++ E++QL E ++RQ ++LL E + Q + L+ Q L Sbjct: 2531 -------EEGVRRKQEELQQL----EQQRRQQEELLAEENQRLREQLQLLEEQHRAAL-- 2577 Query: 146 RGHCSRPGASEVSAAQ 161 H AS+V+A + Sbjct: 2578 -AHSEEVTASQVAATK 2592 Score = 37.7 bits (86), Expect = 0.092 Identities = 34/124 (27%), Positives = 55/124 (44%), Gaps = 34/124 (27%) Query: 103 IRQLLRWKEAEQRQLQQLLHRERDGVV------------------------RQARELQRQ 138 I + LR E E+R +Q ER+ + R+A+ELQ++ Sbjct: 1305 ISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR 1364 Query: 139 LAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAA----LEV 194 + EE+V R + V A Q + +QE L QLR ++ E A+ R +AA L + Sbjct: 1365 MQEEVVRREEAA------VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1418 Query: 195 ERQL 198 E ++ Sbjct: 1419 EEEI 1422 Score = 37.7 bits (86), Expect = 0.092 Identities = 58/251 (23%), Positives = 109/251 (43%), Gaps = 42/251 (16%) Query: 393 TLQAENKQLRRAGCPYQADEKVKRLKVKRAELTGL-------ARRLADRARKLQETNLRA 445 TL+AE ++ + + +RLK++ AE++ A+R +A ++ E R Sbjct: 2335 TLEAERQR------QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2388 Query: 446 VSAPIPGESCAGLELCQVFARQRARDLSEQASAPLAKDKQIEELRQECHLLQARVASGPC 505 A E ++ ++ +Q D A +++ E+L+QE LLQ + Sbjct: 2389 ELAT--QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK-----S 2441 Query: 506 SDLHTGRGGPCTQWLNVRDLDRLQRE--SQREVLRLQRQLMLQQGNGGAWPEAGGQSATC 563 ++ T + Q +++ LQ+ S+++ L LQR+ ++Q + A Sbjct: 2442 EEMQTVQ-----QEQLLQETQALQQSFLSEKDSL-LQRERFIEQEKAKLEQLFQDEVAKA 2495 Query: 564 EEVRRQMLALERELDQRRRECQELGAQAAPARRRGEEAETQL-----------QAALLKN 612 +++R + +++++Q R Q L A ARRR EAE + Q + Sbjct: 2496 QQLREEQQRQQQQMEQER---QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE 2552 Query: 613 AWLAEENGRLQ 623 LAEEN RL+ Sbjct: 2553 ELLAEENQRLR 2563 Score = 37.7 bits (86), Expect = 0.092 Identities = 38/136 (27%), Positives = 71/136 (52%), Gaps = 16/136 (11%) Query: 26 LENQRRE----LEKLR---AELEAERAGWRAERRRFAARERQLR----EEAERERRQLAD 74 LE QR++ E+LR AELE E+ + E + + +++ E+ +E + L Sbjct: 2402 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2461 Query: 75 RLRSKWEA--QRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQA 132 S+ ++ QR R + Q + ++++ + E+ + + +E +QRQ QQ + +ER +V Sbjct: 2462 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ-QQQMEQERQRLVASM 2520 Query: 133 RELQRQL--AEELVNR 146 E +R+ AEE V R Sbjct: 2521 EEARRRQHEAEEGVRR 2536 Score = 36.6 bits (83), Expect = 0.21 Identities = 55/186 (29%), Positives = 82/186 (44%), Gaps = 23/186 (12%) Query: 23 AAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERE--RRQLADR--LRS 78 AA Q E E+L+ E E+A RA+ + A +LR+EAE+E RR A++ LR Sbjct: 2072 AAQSRRQVEEAERLKQSAE-EQAQARAQAQ---AAAEKLRKEAEQEAARRAQAEQAALRQ 2127 Query: 79 KWEAQRSRELRQLQEEMQREREAEIRQ---LLRWKEAEQRQLQQLLHRERDGVVRQAREL 135 K A E + E ++A++ Q LR + E + LL E + +A E Sbjct: 2128 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2187 Query: 136 QR---QLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAAL 192 R Q+ EEL + R E+S + R + LR D Q R+LQ Sbjct: 2188 ARQRSQVEEELFS----VRVQMEELSKLKARIEAENRALILR-DKDNTQ----RFLQEEA 2238 Query: 193 EVERQL 198 E +Q+ Sbjct: 2239 EKMKQV 2244 Score = 33.1 bits (74), Expect = 2.3 Identities = 34/121 (28%), Positives = 52/121 (42%), Gaps = 12/121 (9%) Query: 22 AAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLR------EEAERERRQLADR 75 A + E Q+R+ +++ E + A RRR E +R ++ E++RRQ + Sbjct: 2495 AQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL 2554 Query: 76 LRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQAREL 135 L E QR RE QL EE R A ++ A Q + L RD + A E Sbjct: 2555 LAE--ENQRLREQLQLLEEQHRAALAHSEEV----TASQVAATKTLPNGRDALDGPAAEA 2608 Query: 136 Q 136 + Sbjct: 2609 E 2609 Score = 31.2 bits (69), Expect = 8.6 Identities = 64/283 (22%), Positives = 112/283 (39%), Gaps = 49/283 (17%) Query: 399 KQLRRAGCPYQADEKVKRLKVKRAELTGLARRLADRARKLQETNLRAVSAPIPGESCAGL 458 ++LR A + +++ + + K +L + + + LQET +A+ E + L Sbjct: 2414 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQET--QALQQSFLSEKDSLL 2471 Query: 459 ELCQVFARQRARDLSEQASAPLAKDKQI--EELRQECHLLQAR---VASGPCSDLHTGRG 513 + + +++A+ L + +AK +Q+ E+ RQ+ + Q R VAS Sbjct: 2472 QRERFIEQEKAK-LEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVAS----------- 2519 Query: 514 GPCTQWLNVRDLDRLQRESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRRQMLAL 573 + + R Q E++ V R Q +L E+ RRQ L Sbjct: 2520 --------MEEARRRQHEAEEGVRRKQEELQ-----------------QLEQQRRQQEEL 2554 Query: 574 ERELDQRRRECQELGAQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVE 633 E +QR RE +L + A E T Q A K NGR A + E Sbjct: 2555 LAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTL----PNGR-DALDGPAAEAE 2609 Query: 634 AENSEVRGHLGRACQERDASGLIAEQLLQQAARGQDRQQQLQR 676 E+S + Q +G+++ + LQ+ A+G +L R Sbjct: 2610 PEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELAR 2652 >gi|41322916 plectin 1 isoform 6 [Homo sapiens] Length = 4684 Score = 73.6 bits (179), Expect = 2e-12 Identities = 206/881 (23%), Positives = 337/881 (38%), Gaps = 164/881 (18%) Query: 25 VLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQ------------- 71 V+ Q E+ R E E RA A++RQ +EEAER RRQ Sbjct: 1593 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1652 Query: 72 -LADRLRSKWEAQRSR--------ELR-QLQEEMQREREAEI---RQLLRWKEAEQRQLQ 118 LA R++++ EA R + ELR Q +E +R R+AE+ RQ+ E QR + Sbjct: 1653 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1712 Query: 119 QLLHRERDGVVRQARELQRQLAEELVN----RGHCSRPGASEVSAAQCRCRLQEVLAQLR 174 L +R + +L+R L EE V R R + A + R + L R Sbjct: 1713 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE--R 1770 Query: 175 WQTDGEQAARIRYLQAALEVERQLFLKYILAHFRGHPA-----LSGSPDPQAVHSLE--- 226 WQ +A R+R LQA EV +Q L A + A G + QAV E Sbjct: 1771 WQLKANEALRLR-LQAE-EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1828 Query: 227 ---EPLPQTSSGSCHAPKPACQLGSLDSLSAEVGVRSRSL------GLVSSACSSSP--- 274 E Q + G+ A Q E G + R L L A +++ Sbjct: 1829 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ 1888 Query: 275 --DGLLSTHASSLDCFAPACSRSLDSTRSLPKASKSEERPSSPDTSTPGSRRLSPPPSPL 332 + L+ + ++ + +R+ + +RS + SK + R L+ + L Sbjct: 1889 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR-----LEAEAGRFRELAEEAARL 1943 Query: 333 PPPPPPSAHRKLSNPRGGEGSESQPCEVLTPSPPGLGHHELIKLNWLLA----KALWVLA 388 + ++ ++ VL +G +K +A +A Sbjct: 1944 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 2003 Query: 389 RRCYTLQA-ENKQLRRAGCPYQADEKVKRLKVKRAELTGLARR--LAD---RARKLQETN 442 RR +A + ++L ++AD + + ++++A + L R+ L + R R+ E Sbjct: 2004 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 2063 Query: 443 LRAVSAPIPGESC--AGLELCQVFARQRARDL---SEQASAPLAKDKQI----EELRQEC 493 + A+ A + A LEL R A D EQA A+ +Q+ E R+E Sbjct: 2064 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 2123 Query: 494 HLLQARVASGPCSDLHTGRGGPCTQWLNVRDLDRL-------QRESQREVLRLQRQLMLQ 546 + RV ++ R + +++RL +R +R RQL L Sbjct: 2124 ---EERVQKSLAAEEEAARQRKAA----LEEVERLKAKVEEARRLRERAEQESARQLQLA 2176 Query: 547 QGNGGAWPEAGGQSATCEE------VRRQMLALERELDQRRRECQELGAQAAPARRRGEE 600 Q EA + EE V+++ L++ L Q + +L +A ARR EE Sbjct: 2177 Q-------EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2229 Query: 601 AE--------------------------TQLQAALLKNAWLAEENGRLQAKTDWVRKVEA 634 AE + QA A A E R +A+ + R+ +A Sbjct: 2230 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA 2289 Query: 635 ENSEVRGHLGRACQERDASGLIAEQLLQQAARGQD-----RQQQLQRDPQKALCDLHPSW 689 E + +R A E + AEQ L+Q A+ + R Q + D QK L D Sbjct: 2290 EQAALR-QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD----- 2343 Query: 690 KEIQALQCRPGHPPEQPWETSQMPES------QVKGSRRPKFHARPEDYAVSQPNRD--- 740 +E+Q L+ E + SQ+ E Q++ + K E+ A+ ++D Sbjct: 2344 EELQRLK---AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ 2400 Query: 741 --IQEKREASLEES------PVALGESASVPQVSETVPASQ 773 +QE+ E + + VA E+A + Q++E A Q Sbjct: 2401 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2441 Score = 58.2 bits (139), Expect = 7e-08 Identities = 175/803 (21%), Positives = 304/803 (37%), Gaps = 77/803 (9%) Query: 34 EKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSRELRQLQE 93 E LR E ER AE++R RER EA E+++ ++ +AQ RE ++LQ+ Sbjct: 1476 ETLRRMEEEERL---AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1532 Query: 94 EMQRE---RE---AEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQR---QLAEE-- 142 MQ E RE + +Q R + E +QL+Q E RQA +R ++ EE Sbjct: 1533 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1592 Query: 143 ---LVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAALEVERQLF 199 L + G +E R R +E AQ R E+A R+R Q E +R+ Sbjct: 1593 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQ--EEAERLR-RQVQDESQRKRQ 1649 Query: 200 LKYILAHFRGHPALSGSPDPQAVHSLEEPLPQTSSGSCHAPKPACQLGSLDSLSAEVGVR 259 + LA A + +A+ +LEE Q + + ++ E R Sbjct: 1650 AEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1709 Query: 260 SRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTRSLPKASKSEERPSSP---- 315 S L S S + + + A A R R+ +A R + Sbjct: 1710 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1769 Query: 316 ----DTSTPGSRRLSPPPSPLPPPPPPSAHRKLSNPRGGEGSESQPCEVLTPSPPGLGHH 371 + RL + K E E L Sbjct: 1770 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1829 Query: 372 ELIKLNWL--------LAKALWVLARRCYTLQAENK-----------QLRRAGCPYQADE 412 EL K L LA ++ R T Q E + Q A + E Sbjct: 1830 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1889 Query: 413 KVKRLKVKRAELTGLARRLADRARKLQETNLRAVSAPIPGESCAG--LELCQVFARQRAR 470 L RAE+ L LA +AR +E+ + + E+ AG EL + AR RA Sbjct: 1890 LEAELAKVRAEMEVL---LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1946 Query: 471 DLSEQASAPLAKDKQIEELRQECHLLQARVAS-GPCSDLHTGRGGPCTQWLNVRDLDRLQ 529 + LA++ + + +L ++A+ G + L T + + +RL+ Sbjct: 1947 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE--KEAENERLR 2004 Query: 530 RESQREVLRLQRQLMLQQGNGGAWPE---AGGQSATCEEVRRQMLALERELDQRRRECQE 586 R ++ E + +R+L Q A E A + A+ E+ RQ +E L QRR+ +E Sbjct: 2005 RLAEDEAFQ-RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 2063 Query: 587 -LGAQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLGR 645 L +A+ + +AE +L+ +++ + QA+ + R+ + E R R Sbjct: 2064 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR--R 2121 Query: 646 ACQERDASGLIAEQLLQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQALQCRPGHPPEQ 705 +ER L AE+ + A + + ++++R L +E + L+ R + Sbjct: 2122 EAEERVQKSLAAEE--EAARQRKAALEEVER--------LKAKVEEARRLRER-----AE 2166 Query: 706 PWETSQMPESQVKGSRRPKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQV 765 Q+ +Q +R + + +AV Q +++Q+ + GE+ + + Sbjct: 2167 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2226 Query: 766 SETVPASQPLSKKTSSQSNSSSE 788 +E ++ +++ ++QS E Sbjct: 2227 AEEAEEARVQAEREAAQSRRQVE 2249 Score = 54.3 bits (129), Expect = 1e-06 Identities = 59/188 (31%), Positives = 89/188 (47%), Gaps = 24/188 (12%) Query: 23 AAVLENQRRELE-KLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWE 81 AA E +RRE E +++ L AE A R+R AA E R +A+ E A RLR + E Sbjct: 2113 AAEEERRRREAEERVQKSLAAEE---EAARQRKAALEEVERLKAKVEE---ARRLRERAE 2166 Query: 82 AQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGV--VRQARELQRQL 139 + +R+L+ QE Q+ +AE + + ++++LQQ L +E+ + +R E R+ Sbjct: 2167 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2226 Query: 140 AEELVN-RGHCSRPGA--------------SEVSAAQCRCRLQEVLAQLRWQTDGEQAAR 184 AEE R R A S AQ R + Q +LR + + E A R Sbjct: 2227 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2286 Query: 185 IRYLQAAL 192 + QAAL Sbjct: 2287 AQAEQAAL 2294 Score = 50.8 bits (120), Expect = 1e-05 Identities = 52/191 (27%), Positives = 96/191 (50%), Gaps = 23/191 (12%) Query: 24 AVLENQRRELEKLR-AELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEA 82 +VL+ R E E R A EAE A +AER AA+ R+ EEAER ++ ++ +++ +A Sbjct: 2211 SVLDQLRGEAEAARRAAEEAEEARVQAERE--AAQSRRQVEEAERLKQSAEEQAQARAQA 2268 Query: 83 QRSRELRQLQEEMQREREAEIRQ-LLRWKEAEQRQLQQLLHRE-RDGVVRQARELQRQLA 140 Q + E + + E + R A+ Q LR K+A ++++ H++ + +RQ +++++L Sbjct: 2269 QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK--HKKFAEQTLRQKAQVEQELT 2326 Query: 141 E---ELVNRGH--------CSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQ 189 +L H R A AA+ R +++E L +R Q + + L+ Sbjct: 2327 TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME-----ELSKLK 2381 Query: 190 AALEVERQLFL 200 A +E E + + Sbjct: 2382 ARIEAENRALI 2392 Score = 49.3 bits (116), Expect = 3e-05 Identities = 56/186 (30%), Positives = 89/186 (47%), Gaps = 20/186 (10%) Query: 29 QRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSREL 88 Q EL KL+A +EAE + +R L+EEAE+ ++ + R AQ + L Sbjct: 2373 QMEELSKLKARIEAENRALILRDKDNT--QRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2430 Query: 89 RQLQEEMQREREAEIRQLLRWK-----EAEQRQLQ-QLLHRERDGVVRQARELQ------ 136 RQL EE ++ A ++L+ K EA + + + +LL ++++ QAR LQ Sbjct: 2431 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2490 Query: 137 -RQLAEE---LVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAAL 192 +QLAEE R E+SA R +L+ V R Q E+ A+ R+ + A Sbjct: 2491 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR-VAEMSRAQARAEEDAQ-RFRKQAE 2548 Query: 193 EVERQL 198 E+ +L Sbjct: 2549 EIGEKL 2554 Score = 47.4 bits (111), Expect = 1e-04 Identities = 56/204 (27%), Positives = 81/204 (39%), Gaps = 46/204 (22%) Query: 24 AVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQ 83 A L+ + + R ELEAE A RAE A + AE E R +++ + + EA+ Sbjct: 1874 ARLQREAAAATQKRQELEAELAKVRAEMEVLLAS----KARAEEESRSTSEKSKQRLEAE 1929 Query: 84 RSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEEL 143 R R+L EE R R L + QRQL + + RQ E +R LAE+L Sbjct: 1930 AGR-FRELAEEAARLR------ALAEEAKRQRQLAE------EDAARQRAEAERVLAEKL 1976 Query: 144 VNRGHCSRPGAS-----------------------------EVSAAQCRCRLQEVLAQLR 174 G +R E AAQ + ++E LAQLR Sbjct: 1977 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 2036 Query: 175 WQTDGEQAARIRYLQAALEVERQL 198 +D E + ++ L RQ+ Sbjct: 2037 KASDSELERQKGLVEDTLRQRRQV 2060 Score = 46.6 bits (109), Expect = 2e-04 Identities = 58/189 (30%), Positives = 90/189 (47%), Gaps = 36/189 (19%) Query: 32 ELEKLRAEL-EAERAGWRAERRRFAARER-----QLREEAERERRQLADRLRSKWEAQR- 84 EL++L+AE EA R + E F+ R + +L+ E E R L LR K QR Sbjct: 2345 ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI--LRDKDNTQRF 2402 Query: 85 ----SRELRQLQEEMQR-----EREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQAREL 135 + +++Q+ EE R + A +RQL A+QR L + + +E+ V++A L Sbjct: 2403 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2462 Query: 136 QRQLAEELVNRGHCSRPGASEVSAAQCRCRLQE----VLAQLRWQTDGEQ----AARIRY 187 + + EL+ + E++ Q R RLQE + QL +T G Q A R R Sbjct: 2463 KAE--AELLQQ-------QKELAQEQAR-RLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2512 Query: 188 LQAALEVER 196 L+ + E ER Sbjct: 2513 LEMSAEAER 2521 Score = 44.7 bits (104), Expect = 8e-04 Identities = 62/184 (33%), Positives = 86/184 (46%), Gaps = 15/184 (8%) Query: 22 AAAVLENQR--RELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSK 79 A A E QR + LE+LR L+AE A R R+ R RQ++ E +R L+SK Sbjct: 1662 AEAAREKQRALQALEELR--LQAEEAE-RRLRQAEVERARQVQVALETAQRSAEAELQSK 1718 Query: 80 WEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQL-LHRERDGVVRQARELQRQ 138 A + + QL+ +Q E A + QL +EAE+R QQ R R+ R+ Q + Sbjct: 1719 -RASFAEKTAQLERSLQEEHVA-VAQLR--EEAERRAQQQAEAERAREEAERELERWQLK 1774 Query: 139 LAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDG---EQAARIRYL-QAALEV 194 E L R A + S AQ Q+ A+ + G EQA R R L + LE Sbjct: 1775 ANEALRLRLQAEEV-AQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK 1833 Query: 195 ERQL 198 +RQL Sbjct: 1834 QRQL 1837 Score = 44.7 bits (104), Expect = 8e-04 Identities = 33/122 (27%), Positives = 67/122 (54%), Gaps = 11/122 (9%) Query: 40 LEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSRELRQLQEEMQRER 99 +E E+A + A+ +QLREE +R+++Q+ E +R R + ++E +R+ Sbjct: 2646 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM--------EQERQRLVASMEEARRRQH 2697 Query: 100 EAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEELVNRGHCSRPGASEVSA 159 EAE + +R K+ E +QL+Q ++ + + + + L+ QL + L + + + EV+A Sbjct: 2698 EAE--EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL-QLLEEQHRAALAHSEEVTA 2754 Query: 160 AQ 161 +Q Sbjct: 2755 SQ 2756 Score = 41.2 bits (95), Expect = 0.008 Identities = 34/125 (27%), Positives = 61/125 (48%), Gaps = 20/125 (16%) Query: 30 RRELEKLRAELEAERAGWRAERRRFAARER------------QLREEAERERRQLADRLR 77 R E + R +AE G + R A +E+ Q +AER R +A+ R Sbjct: 2535 RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER 2594 Query: 78 SKWEAQRSRELRQLQ-EEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQ 136 K + Q+ +L QL+ EEMQ ++ ++ Q E + LQQ E+D ++++ R ++ Sbjct: 2595 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQ-------ETQALQQSFLSEKDSLLQRERFIE 2647 Query: 137 RQLAE 141 ++ A+ Sbjct: 2648 QEKAK 2652 Score = 40.4 bits (93), Expect = 0.014 Identities = 40/140 (28%), Positives = 65/140 (46%), Gaps = 20/140 (14%) Query: 26 LENQRRELEKLRAELEAERAGWRAER----------RRFAARERQLREEAERERRQLADR 75 LE + L+KLRA+ EA++ + A R R R + E ER R ++A + Sbjct: 1262 LEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA-Q 1320 Query: 76 LRSKWEA------QRSRELRQLQEEMQREREA--EIRQLLRWKEAEQRQLQQLLHRERDG 127 L +W+A R REL QL +++ RE+ + L+ Q Q+Q + + Sbjct: 1321 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1380 Query: 128 VVRQARELQRQLAEELVNRG 147 V Q R+ ++ L EE+ G Sbjct: 1381 VREQLRQ-EQALLEEIERHG 1399 Score = 39.7 bits (91), Expect = 0.024 Identities = 42/174 (24%), Positives = 72/174 (41%), Gaps = 7/174 (4%) Query: 24 AVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQ 83 A +E R+ L + A +++R FA + QL + E +A +LR EA+ Sbjct: 1692 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVA-QLRE--EAE 1748 Query: 84 RSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEEL 143 R Q Q E +R RE R+L RW+ L+ L E + + + + +E Sbjct: 1749 RRA---QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1805 Query: 144 VNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAALEVERQ 197 R R G +E A + R ++ L + R +G R+ Q + + + Sbjct: 1806 AER-EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE 1858 Score = 39.7 bits (91), Expect = 0.024 Identities = 53/186 (28%), Positives = 84/186 (45%), Gaps = 16/186 (8%) Query: 23 AAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWE- 81 AA L +E +LR E + A RA + + Q +EA R + + A+ L+ + E Sbjct: 2417 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE-AELLQQQKEL 2475 Query: 82 -AQRSRELRQLQEEMQREREAEIRQLLRWKEAE-QRQLQQLLHRERDGVVRQARELQRQL 139 +++R L++ +E+M ++ E + R EAE QRQL+ ER + + Sbjct: 2476 AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2535 Query: 140 AEELVNRGHCSRPGASEVS--------AAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAA 191 AEE R R A E+ A Q + L + L R Q+D A R+R A Sbjct: 2536 AEEDAQR---FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD-HDAERLREAIAE 2591 Query: 192 LEVERQ 197 LE E++ Sbjct: 2592 LEREKE 2597 Score = 38.5 bits (88), Expect = 0.054 Identities = 35/136 (25%), Positives = 67/136 (49%), Gaps = 20/136 (14%) Query: 26 LENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRS 85 +E ++ +LE+L + A+ R E++R +++Q+ +E +R + + R + EA Sbjct: 2646 IEQEKAKLEQLFQDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEA--- 2699 Query: 86 RELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEELVN 145 EE R ++ E++QL E ++RQ ++LL E + Q + L+ Q L Sbjct: 2700 -------EEGVRRKQEELQQL----EQQRRQQEELLAEENQRLREQLQLLEEQHRAAL-- 2746 Query: 146 RGHCSRPGASEVSAAQ 161 H AS+V+A + Sbjct: 2747 -AHSEEVTASQVAATK 2761 Score = 37.7 bits (86), Expect = 0.092 Identities = 34/124 (27%), Positives = 55/124 (44%), Gaps = 34/124 (27%) Query: 103 IRQLLRWKEAEQRQLQQLLHRERDGVV------------------------RQARELQRQ 138 I + LR E E+R +Q ER+ + R+A+ELQ++ Sbjct: 1474 ISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR 1533 Query: 139 LAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAA----LEV 194 + EE+V R + V A Q + +QE L QLR ++ E A+ R +AA L + Sbjct: 1534 MQEEVVRREEAA------VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1587 Query: 195 ERQL 198 E ++ Sbjct: 1588 EEEI 1591 Score = 37.7 bits (86), Expect = 0.092 Identities = 58/251 (23%), Positives = 109/251 (43%), Gaps = 42/251 (16%) Query: 393 TLQAENKQLRRAGCPYQADEKVKRLKVKRAELTGL-------ARRLADRARKLQETNLRA 445 TL+AE ++ + + +RLK++ AE++ A+R +A ++ E R Sbjct: 2504 TLEAERQR------QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2557 Query: 446 VSAPIPGESCAGLELCQVFARQRARDLSEQASAPLAKDKQIEELRQECHLLQARVASGPC 505 A E ++ ++ +Q D A +++ E+L+QE LLQ + Sbjct: 2558 ELAT--QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK-----S 2610 Query: 506 SDLHTGRGGPCTQWLNVRDLDRLQRE--SQREVLRLQRQLMLQQGNGGAWPEAGGQSATC 563 ++ T + Q +++ LQ+ S+++ L LQR+ ++Q + A Sbjct: 2611 EEMQTVQ-----QEQLLQETQALQQSFLSEKDSL-LQRERFIEQEKAKLEQLFQDEVAKA 2664 Query: 564 EEVRRQMLALERELDQRRRECQELGAQAAPARRRGEEAETQL-----------QAALLKN 612 +++R + +++++Q R Q L A ARRR EAE + Q + Sbjct: 2665 QQLREEQQRQQQQMEQER---QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE 2721 Query: 613 AWLAEENGRLQ 623 LAEEN RL+ Sbjct: 2722 ELLAEENQRLR 2732 Score = 37.7 bits (86), Expect = 0.092 Identities = 38/136 (27%), Positives = 71/136 (52%), Gaps = 16/136 (11%) Query: 26 LENQRRE----LEKLR---AELEAERAGWRAERRRFAARERQLR----EEAERERRQLAD 74 LE QR++ E+LR AELE E+ + E + + +++ E+ +E + L Sbjct: 2571 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2630 Query: 75 RLRSKWEA--QRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQA 132 S+ ++ QR R + Q + ++++ + E+ + + +E +QRQ QQ + +ER +V Sbjct: 2631 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ-QQQMEQERQRLVASM 2689 Query: 133 RELQRQL--AEELVNR 146 E +R+ AEE V R Sbjct: 2690 EEARRRQHEAEEGVRR 2705 Score = 36.6 bits (83), Expect = 0.21 Identities = 55/186 (29%), Positives = 82/186 (44%), Gaps = 23/186 (12%) Query: 23 AAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERE--RRQLADR--LRS 78 AA Q E E+L+ E E+A RA+ + A +LR+EAE+E RR A++ LR Sbjct: 2241 AAQSRRQVEEAERLKQSAE-EQAQARAQAQ---AAAEKLRKEAEQEAARRAQAEQAALRQ 2296 Query: 79 KWEAQRSRELRQLQEEMQREREAEIRQ---LLRWKEAEQRQLQQLLHRERDGVVRQAREL 135 K A E + E ++A++ Q LR + E + LL E + +A E Sbjct: 2297 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2356 Query: 136 QR---QLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAAL 192 R Q+ EEL + R E+S + R + LR D Q R+LQ Sbjct: 2357 ARQRSQVEEELFS----VRVQMEELSKLKARIEAENRALILR-DKDNTQ----RFLQEEA 2407 Query: 193 EVERQL 198 E +Q+ Sbjct: 2408 EKMKQV 2413 Score = 33.1 bits (74), Expect = 2.3 Identities = 34/121 (28%), Positives = 52/121 (42%), Gaps = 12/121 (9%) Query: 22 AAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLR------EEAERERRQLADR 75 A + E Q+R+ +++ E + A RRR E +R ++ E++RRQ + Sbjct: 2664 AQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL 2723 Query: 76 LRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQAREL 135 L E QR RE QL EE R A ++ A Q + L RD + A E Sbjct: 2724 LAE--ENQRLREQLQLLEEQHRAALAHSEEV----TASQVAATKTLPNGRDALDGPAAEA 2777 Query: 136 Q 136 + Sbjct: 2778 E 2778 Score = 31.2 bits (69), Expect = 8.6 Identities = 64/283 (22%), Positives = 112/283 (39%), Gaps = 49/283 (17%) Query: 399 KQLRRAGCPYQADEKVKRLKVKRAELTGLARRLADRARKLQETNLRAVSAPIPGESCAGL 458 ++LR A + +++ + + K +L + + + LQET +A+ E + L Sbjct: 2583 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQET--QALQQSFLSEKDSLL 2640 Query: 459 ELCQVFARQRARDLSEQASAPLAKDKQI--EELRQECHLLQAR---VASGPCSDLHTGRG 513 + + +++A+ L + +AK +Q+ E+ RQ+ + Q R VAS Sbjct: 2641 QRERFIEQEKAK-LEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVAS----------- 2688 Query: 514 GPCTQWLNVRDLDRLQRESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRRQMLAL 573 + + R Q E++ V R Q +L E+ RRQ L Sbjct: 2689 --------MEEARRRQHEAEEGVRRKQEELQ-----------------QLEQQRRQQEEL 2723 Query: 574 ERELDQRRRECQELGAQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVE 633 E +QR RE +L + A E T Q A K NGR A + E Sbjct: 2724 LAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTL----PNGR-DALDGPAAEAE 2778 Query: 634 AENSEVRGHLGRACQERDASGLIAEQLLQQAARGQDRQQQLQR 676 E+S + Q +G+++ + LQ+ A+G +L R Sbjct: 2779 PEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELAR 2821 >gi|41322908 plectin 1 isoform 3 [Homo sapiens] Length = 4525 Score = 73.6 bits (179), Expect = 2e-12 Identities = 206/881 (23%), Positives = 337/881 (38%), Gaps = 164/881 (18%) Query: 25 VLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQ------------- 71 V+ Q E+ R E E RA A++RQ +EEAER RRQ Sbjct: 1434 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1493 Query: 72 -LADRLRSKWEAQRSR--------ELR-QLQEEMQREREAEI---RQLLRWKEAEQRQLQ 118 LA R++++ EA R + ELR Q +E +R R+AE+ RQ+ E QR + Sbjct: 1494 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1553 Query: 119 QLLHRERDGVVRQARELQRQLAEELVN----RGHCSRPGASEVSAAQCRCRLQEVLAQLR 174 L +R + +L+R L EE V R R + A + R + L R Sbjct: 1554 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE--R 1611 Query: 175 WQTDGEQAARIRYLQAALEVERQLFLKYILAHFRGHPA-----LSGSPDPQAVHSLE--- 226 WQ +A R+R LQA EV +Q L A + A G + QAV E Sbjct: 1612 WQLKANEALRLR-LQAE-EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1669 Query: 227 ---EPLPQTSSGSCHAPKPACQLGSLDSLSAEVGVRSRSL------GLVSSACSSSP--- 274 E Q + G+ A Q E G + R L L A +++ Sbjct: 1670 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ 1729 Query: 275 --DGLLSTHASSLDCFAPACSRSLDSTRSLPKASKSEERPSSPDTSTPGSRRLSPPPSPL 332 + L+ + ++ + +R+ + +RS + SK + R L+ + L Sbjct: 1730 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR-----LEAEAGRFRELAEEAARL 1784 Query: 333 PPPPPPSAHRKLSNPRGGEGSESQPCEVLTPSPPGLGHHELIKLNWLLA----KALWVLA 388 + ++ ++ VL +G +K +A +A Sbjct: 1785 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 1844 Query: 389 RRCYTLQA-ENKQLRRAGCPYQADEKVKRLKVKRAELTGLARR--LAD---RARKLQETN 442 RR +A + ++L ++AD + + ++++A + L R+ L + R R+ E Sbjct: 1845 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1904 Query: 443 LRAVSAPIPGESC--AGLELCQVFARQRARDL---SEQASAPLAKDKQI----EELRQEC 493 + A+ A + A LEL R A D EQA A+ +Q+ E R+E Sbjct: 1905 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 1964 Query: 494 HLLQARVASGPCSDLHTGRGGPCTQWLNVRDLDRL-------QRESQREVLRLQRQLMLQ 546 + RV ++ R + +++RL +R +R RQL L Sbjct: 1965 ---EERVQKSLAAEEEAARQRKAA----LEEVERLKAKVEEARRLRERAEQESARQLQLA 2017 Query: 547 QGNGGAWPEAGGQSATCEE------VRRQMLALERELDQRRRECQELGAQAAPARRRGEE 600 Q EA + EE V+++ L++ L Q + +L +A ARR EE Sbjct: 2018 Q-------EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2070 Query: 601 AE--------------------------TQLQAALLKNAWLAEENGRLQAKTDWVRKVEA 634 AE + QA A A E R +A+ + R+ +A Sbjct: 2071 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA 2130 Query: 635 ENSEVRGHLGRACQERDASGLIAEQLLQQAARGQD-----RQQQLQRDPQKALCDLHPSW 689 E + +R A E + AEQ L+Q A+ + R Q + D QK L D Sbjct: 2131 EQAALR-QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD----- 2184 Query: 690 KEIQALQCRPGHPPEQPWETSQMPES------QVKGSRRPKFHARPEDYAVSQPNRD--- 740 +E+Q L+ E + SQ+ E Q++ + K E+ A+ ++D Sbjct: 2185 EELQRLK---AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ 2241 Query: 741 --IQEKREASLEES------PVALGESASVPQVSETVPASQ 773 +QE+ E + + VA E+A + Q++E A Q Sbjct: 2242 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2282 Score = 58.2 bits (139), Expect = 7e-08 Identities = 175/803 (21%), Positives = 304/803 (37%), Gaps = 77/803 (9%) Query: 34 EKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSRELRQLQE 93 E LR E ER AE++R RER EA E+++ ++ +AQ RE ++LQ+ Sbjct: 1317 ETLRRMEEEERL---AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1373 Query: 94 EMQRE---RE---AEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQR---QLAEE-- 142 MQ E RE + +Q R + E +QL+Q E RQA +R ++ EE Sbjct: 1374 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1433 Query: 143 ---LVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAALEVERQLF 199 L + G +E R R +E AQ R E+A R+R Q E +R+ Sbjct: 1434 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQ--EEAERLR-RQVQDESQRKRQ 1490 Query: 200 LKYILAHFRGHPALSGSPDPQAVHSLEEPLPQTSSGSCHAPKPACQLGSLDSLSAEVGVR 259 + LA A + +A+ +LEE Q + + ++ E R Sbjct: 1491 AEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1550 Query: 260 SRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTRSLPKASKSEERPSSP---- 315 S L S S + + + A A R R+ +A R + Sbjct: 1551 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1610 Query: 316 ----DTSTPGSRRLSPPPSPLPPPPPPSAHRKLSNPRGGEGSESQPCEVLTPSPPGLGHH 371 + RL + K E E L Sbjct: 1611 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1670 Query: 372 ELIKLNWL--------LAKALWVLARRCYTLQAENK-----------QLRRAGCPYQADE 412 EL K L LA ++ R T Q E + Q A + E Sbjct: 1671 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1730 Query: 413 KVKRLKVKRAELTGLARRLADRARKLQETNLRAVSAPIPGESCAG--LELCQVFARQRAR 470 L RAE+ L LA +AR +E+ + + E+ AG EL + AR RA Sbjct: 1731 LEAELAKVRAEMEVL---LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1787 Query: 471 DLSEQASAPLAKDKQIEELRQECHLLQARVAS-GPCSDLHTGRGGPCTQWLNVRDLDRLQ 529 + LA++ + + +L ++A+ G + L T + + +RL+ Sbjct: 1788 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE--KEAENERLR 1845 Query: 530 RESQREVLRLQRQLMLQQGNGGAWPE---AGGQSATCEEVRRQMLALERELDQRRRECQE 586 R ++ E + +R+L Q A E A + A+ E+ RQ +E L QRR+ +E Sbjct: 1846 RLAEDEAFQ-RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1904 Query: 587 -LGAQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLGR 645 L +A+ + +AE +L+ +++ + QA+ + R+ + E R R Sbjct: 1905 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR--R 1962 Query: 646 ACQERDASGLIAEQLLQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQALQCRPGHPPEQ 705 +ER L AE+ + A + + ++++R L +E + L+ R + Sbjct: 1963 EAEERVQKSLAAEE--EAARQRKAALEEVER--------LKAKVEEARRLRER-----AE 2007 Query: 706 PWETSQMPESQVKGSRRPKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQV 765 Q+ +Q +R + + +AV Q +++Q+ + GE+ + + Sbjct: 2008 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2067 Query: 766 SETVPASQPLSKKTSSQSNSSSE 788 +E ++ +++ ++QS E Sbjct: 2068 AEEAEEARVQAEREAAQSRRQVE 2090 Score = 54.3 bits (129), Expect = 1e-06 Identities = 59/188 (31%), Positives = 89/188 (47%), Gaps = 24/188 (12%) Query: 23 AAVLENQRRELE-KLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWE 81 AA E +RRE E +++ L AE A R+R AA E R +A+ E A RLR + E Sbjct: 1954 AAEEERRRREAEERVQKSLAAEE---EAARQRKAALEEVERLKAKVEE---ARRLRERAE 2007 Query: 82 AQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGV--VRQARELQRQL 139 + +R+L+ QE Q+ +AE + + ++++LQQ L +E+ + +R E R+ Sbjct: 2008 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2067 Query: 140 AEELVN-RGHCSRPGA--------------SEVSAAQCRCRLQEVLAQLRWQTDGEQAAR 184 AEE R R A S AQ R + Q +LR + + E A R Sbjct: 2068 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2127 Query: 185 IRYLQAAL 192 + QAAL Sbjct: 2128 AQAEQAAL 2135 Score = 50.8 bits (120), Expect = 1e-05 Identities = 52/191 (27%), Positives = 96/191 (50%), Gaps = 23/191 (12%) Query: 24 AVLENQRRELEKLR-AELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEA 82 +VL+ R E E R A EAE A +AER AA+ R+ EEAER ++ ++ +++ +A Sbjct: 2052 SVLDQLRGEAEAARRAAEEAEEARVQAERE--AAQSRRQVEEAERLKQSAEEQAQARAQA 2109 Query: 83 QRSRELRQLQEEMQREREAEIRQ-LLRWKEAEQRQLQQLLHRE-RDGVVRQARELQRQLA 140 Q + E + + E + R A+ Q LR K+A ++++ H++ + +RQ +++++L Sbjct: 2110 QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK--HKKFAEQTLRQKAQVEQELT 2167 Query: 141 E---ELVNRGH--------CSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQ 189 +L H R A AA+ R +++E L +R Q + + L+ Sbjct: 2168 TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME-----ELSKLK 2222 Query: 190 AALEVERQLFL 200 A +E E + + Sbjct: 2223 ARIEAENRALI 2233 Score = 49.3 bits (116), Expect = 3e-05 Identities = 56/186 (30%), Positives = 89/186 (47%), Gaps = 20/186 (10%) Query: 29 QRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSREL 88 Q EL KL+A +EAE + +R L+EEAE+ ++ + R AQ + L Sbjct: 2214 QMEELSKLKARIEAENRALILRDKDNT--QRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2271 Query: 89 RQLQEEMQREREAEIRQLLRWK-----EAEQRQLQ-QLLHRERDGVVRQARELQ------ 136 RQL EE ++ A ++L+ K EA + + + +LL ++++ QAR LQ Sbjct: 2272 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2331 Query: 137 -RQLAEE---LVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAAL 192 +QLAEE R E+SA R +L+ V R Q E+ A+ R+ + A Sbjct: 2332 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR-VAEMSRAQARAEEDAQ-RFRKQAE 2389 Query: 193 EVERQL 198 E+ +L Sbjct: 2390 EIGEKL 2395 Score = 47.4 bits (111), Expect = 1e-04 Identities = 56/204 (27%), Positives = 81/204 (39%), Gaps = 46/204 (22%) Query: 24 AVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQ 83 A L+ + + R ELEAE A RAE A + AE E R +++ + + EA+ Sbjct: 1715 ARLQREAAAATQKRQELEAELAKVRAEMEVLLAS----KARAEEESRSTSEKSKQRLEAE 1770 Query: 84 RSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEEL 143 R R+L EE R R L + QRQL + + RQ E +R LAE+L Sbjct: 1771 AGR-FRELAEEAARLR------ALAEEAKRQRQLAE------EDAARQRAEAERVLAEKL 1817 Query: 144 VNRGHCSRPGAS-----------------------------EVSAAQCRCRLQEVLAQLR 174 G +R E AAQ + ++E LAQLR Sbjct: 1818 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1877 Query: 175 WQTDGEQAARIRYLQAALEVERQL 198 +D E + ++ L RQ+ Sbjct: 1878 KASDSELERQKGLVEDTLRQRRQV 1901 Score = 46.6 bits (109), Expect = 2e-04 Identities = 58/189 (30%), Positives = 90/189 (47%), Gaps = 36/189 (19%) Query: 32 ELEKLRAEL-EAERAGWRAERRRFAARER-----QLREEAERERRQLADRLRSKWEAQR- 84 EL++L+AE EA R + E F+ R + +L+ E E R L LR K QR Sbjct: 2186 ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI--LRDKDNTQRF 2243 Query: 85 ----SRELRQLQEEMQR-----EREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQAREL 135 + +++Q+ EE R + A +RQL A+QR L + + +E+ V++A L Sbjct: 2244 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2303 Query: 136 QRQLAEELVNRGHCSRPGASEVSAAQCRCRLQE----VLAQLRWQTDGEQ----AARIRY 187 + + EL+ + E++ Q R RLQE + QL +T G Q A R R Sbjct: 2304 KAE--AELLQQ-------QKELAQEQAR-RLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2353 Query: 188 LQAALEVER 196 L+ + E ER Sbjct: 2354 LEMSAEAER 2362 Score = 44.7 bits (104), Expect = 8e-04 Identities = 62/184 (33%), Positives = 86/184 (46%), Gaps = 15/184 (8%) Query: 22 AAAVLENQR--RELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSK 79 A A E QR + LE+LR L+AE A R R+ R RQ++ E +R L+SK Sbjct: 1503 AEAAREKQRALQALEELR--LQAEEAE-RRLRQAEVERARQVQVALETAQRSAEAELQSK 1559 Query: 80 WEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQL-LHRERDGVVRQARELQRQ 138 A + + QL+ +Q E A + QL +EAE+R QQ R R+ R+ Q + Sbjct: 1560 -RASFAEKTAQLERSLQEEHVA-VAQLR--EEAERRAQQQAEAERAREEAERELERWQLK 1615 Query: 139 LAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDG---EQAARIRYL-QAALEV 194 E L R A + S AQ Q+ A+ + G EQA R R L + LE Sbjct: 1616 ANEALRLRLQAEEV-AQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK 1674 Query: 195 ERQL 198 +RQL Sbjct: 1675 QRQL 1678 Score = 44.7 bits (104), Expect = 8e-04 Identities = 33/122 (27%), Positives = 67/122 (54%), Gaps = 11/122 (9%) Query: 40 LEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSRELRQLQEEMQRER 99 +E E+A + A+ +QLREE +R+++Q+ E +R R + ++E +R+ Sbjct: 2487 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM--------EQERQRLVASMEEARRRQH 2538 Query: 100 EAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEELVNRGHCSRPGASEVSA 159 EAE + +R K+ E +QL+Q ++ + + + + L+ QL + L + + + EV+A Sbjct: 2539 EAE--EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL-QLLEEQHRAALAHSEEVTA 2595 Query: 160 AQ 161 +Q Sbjct: 2596 SQ 2597 Score = 41.2 bits (95), Expect = 0.008 Identities = 34/125 (27%), Positives = 61/125 (48%), Gaps = 20/125 (16%) Query: 30 RRELEKLRAELEAERAGWRAERRRFAARER------------QLREEAERERRQLADRLR 77 R E + R +AE G + R A +E+ Q +AER R +A+ R Sbjct: 2376 RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER 2435 Query: 78 SKWEAQRSRELRQLQ-EEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQ 136 K + Q+ +L QL+ EEMQ ++ ++ Q E + LQQ E+D ++++ R ++ Sbjct: 2436 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQ-------ETQALQQSFLSEKDSLLQRERFIE 2488 Query: 137 RQLAE 141 ++ A+ Sbjct: 2489 QEKAK 2493 Score = 40.4 bits (93), Expect = 0.014 Identities = 40/140 (28%), Positives = 65/140 (46%), Gaps = 20/140 (14%) Query: 26 LENQRRELEKLRAELEAERAGWRAER----------RRFAARERQLREEAERERRQLADR 75 LE + L+KLRA+ EA++ + A R R R + E ER R ++A + Sbjct: 1103 LEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA-Q 1161 Query: 76 LRSKWEA------QRSRELRQLQEEMQREREA--EIRQLLRWKEAEQRQLQQLLHRERDG 127 L +W+A R REL QL +++ RE+ + L+ Q Q+Q + + Sbjct: 1162 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1221 Query: 128 VVRQARELQRQLAEELVNRG 147 V Q R+ ++ L EE+ G Sbjct: 1222 VREQLRQ-EQALLEEIERHG 1240 Score = 39.7 bits (91), Expect = 0.024 Identities = 42/174 (24%), Positives = 72/174 (41%), Gaps = 7/174 (4%) Query: 24 AVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQ 83 A +E R+ L + A +++R FA + QL + E +A +LR EA+ Sbjct: 1533 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVA-QLRE--EAE 1589 Query: 84 RSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEEL 143 R Q Q E +R RE R+L RW+ L+ L E + + + + +E Sbjct: 1590 RRA---QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1646 Query: 144 VNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAALEVERQ 197 R R G +E A + R ++ L + R +G R+ Q + + + Sbjct: 1647 AER-EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE 1699 Score = 39.7 bits (91), Expect = 0.024 Identities = 53/186 (28%), Positives = 84/186 (45%), Gaps = 16/186 (8%) Query: 23 AAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWE- 81 AA L +E +LR E + A RA + + Q +EA R + + A+ L+ + E Sbjct: 2258 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE-AELLQQQKEL 2316 Query: 82 -AQRSRELRQLQEEMQREREAEIRQLLRWKEAE-QRQLQQLLHRERDGVVRQARELQRQL 139 +++R L++ +E+M ++ E + R EAE QRQL+ ER + + Sbjct: 2317 AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2376 Query: 140 AEELVNRGHCSRPGASEVS--------AAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAA 191 AEE R R A E+ A Q + L + L R Q+D A R+R A Sbjct: 2377 AEEDAQR---FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD-HDAERLREAIAE 2432 Query: 192 LEVERQ 197 LE E++ Sbjct: 2433 LEREKE 2438 Score = 38.5 bits (88), Expect = 0.054 Identities = 35/136 (25%), Positives = 67/136 (49%), Gaps = 20/136 (14%) Query: 26 LENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRS 85 +E ++ +LE+L + A+ R E++R +++Q+ +E +R + + R + EA Sbjct: 2487 IEQEKAKLEQLFQDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEA--- 2540 Query: 86 RELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEELVN 145 EE R ++ E++QL E ++RQ ++LL E + Q + L+ Q L Sbjct: 2541 -------EEGVRRKQEELQQL----EQQRRQQEELLAEENQRLREQLQLLEEQHRAAL-- 2587 Query: 146 RGHCSRPGASEVSAAQ 161 H AS+V+A + Sbjct: 2588 -AHSEEVTASQVAATK 2602 Score = 37.7 bits (86), Expect = 0.092 Identities = 34/124 (27%), Positives = 55/124 (44%), Gaps = 34/124 (27%) Query: 103 IRQLLRWKEAEQRQLQQLLHRERDGVV------------------------RQARELQRQ 138 I + LR E E+R +Q ER+ + R+A+ELQ++ Sbjct: 1315 ISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR 1374 Query: 139 LAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAA----LEV 194 + EE+V R + V A Q + +QE L QLR ++ E A+ R +AA L + Sbjct: 1375 MQEEVVRREEAA------VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1428 Query: 195 ERQL 198 E ++ Sbjct: 1429 EEEI 1432 Score = 37.7 bits (86), Expect = 0.092 Identities = 58/251 (23%), Positives = 109/251 (43%), Gaps = 42/251 (16%) Query: 393 TLQAENKQLRRAGCPYQADEKVKRLKVKRAELTGL-------ARRLADRARKLQETNLRA 445 TL+AE ++ + + +RLK++ AE++ A+R +A ++ E R Sbjct: 2345 TLEAERQR------QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2398 Query: 446 VSAPIPGESCAGLELCQVFARQRARDLSEQASAPLAKDKQIEELRQECHLLQARVASGPC 505 A E ++ ++ +Q D A +++ E+L+QE LLQ + Sbjct: 2399 ELAT--QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK-----S 2451 Query: 506 SDLHTGRGGPCTQWLNVRDLDRLQRE--SQREVLRLQRQLMLQQGNGGAWPEAGGQSATC 563 ++ T + Q +++ LQ+ S+++ L LQR+ ++Q + A Sbjct: 2452 EEMQTVQ-----QEQLLQETQALQQSFLSEKDSL-LQRERFIEQEKAKLEQLFQDEVAKA 2505 Query: 564 EEVRRQMLALERELDQRRRECQELGAQAAPARRRGEEAETQL-----------QAALLKN 612 +++R + +++++Q R Q L A ARRR EAE + Q + Sbjct: 2506 QQLREEQQRQQQQMEQER---QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE 2562 Query: 613 AWLAEENGRLQ 623 LAEEN RL+ Sbjct: 2563 ELLAEENQRLR 2573 Score = 37.7 bits (86), Expect = 0.092 Identities = 38/136 (27%), Positives = 71/136 (52%), Gaps = 16/136 (11%) Query: 26 LENQRRE----LEKLR---AELEAERAGWRAERRRFAARERQLR----EEAERERRQLAD 74 LE QR++ E+LR AELE E+ + E + + +++ E+ +E + L Sbjct: 2412 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2471 Query: 75 RLRSKWEA--QRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQA 132 S+ ++ QR R + Q + ++++ + E+ + + +E +QRQ QQ + +ER +V Sbjct: 2472 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ-QQQMEQERQRLVASM 2530 Query: 133 RELQRQL--AEELVNR 146 E +R+ AEE V R Sbjct: 2531 EEARRRQHEAEEGVRR 2546 Score = 36.6 bits (83), Expect = 0.21 Identities = 55/186 (29%), Positives = 82/186 (44%), Gaps = 23/186 (12%) Query: 23 AAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERE--RRQLADR--LRS 78 AA Q E E+L+ E E+A RA+ + A +LR+EAE+E RR A++ LR Sbjct: 2082 AAQSRRQVEEAERLKQSAE-EQAQARAQAQ---AAAEKLRKEAEQEAARRAQAEQAALRQ 2137 Query: 79 KWEAQRSRELRQLQEEMQREREAEIRQ---LLRWKEAEQRQLQQLLHRERDGVVRQAREL 135 K A E + E ++A++ Q LR + E + LL E + +A E Sbjct: 2138 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2197 Query: 136 QR---QLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAAL 192 R Q+ EEL + R E+S + R + LR D Q R+LQ Sbjct: 2198 ARQRSQVEEELFS----VRVQMEELSKLKARIEAENRALILR-DKDNTQ----RFLQEEA 2248 Query: 193 EVERQL 198 E +Q+ Sbjct: 2249 EKMKQV 2254 Score = 33.1 bits (74), Expect = 2.3 Identities = 34/121 (28%), Positives = 52/121 (42%), Gaps = 12/121 (9%) Query: 22 AAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLR------EEAERERRQLADR 75 A + E Q+R+ +++ E + A RRR E +R ++ E++RRQ + Sbjct: 2505 AQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL 2564 Query: 76 LRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQAREL 135 L E QR RE QL EE R A ++ A Q + L RD + A E Sbjct: 2565 LAE--ENQRLREQLQLLEEQHRAALAHSEEV----TASQVAATKTLPNGRDALDGPAAEA 2618 Query: 136 Q 136 + Sbjct: 2619 E 2619 Score = 31.2 bits (69), Expect = 8.6 Identities = 64/283 (22%), Positives = 112/283 (39%), Gaps = 49/283 (17%) Query: 399 KQLRRAGCPYQADEKVKRLKVKRAELTGLARRLADRARKLQETNLRAVSAPIPGESCAGL 458 ++LR A + +++ + + K +L + + + LQET +A+ E + L Sbjct: 2424 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQET--QALQQSFLSEKDSLL 2481 Query: 459 ELCQVFARQRARDLSEQASAPLAKDKQI--EELRQECHLLQAR---VASGPCSDLHTGRG 513 + + +++A+ L + +AK +Q+ E+ RQ+ + Q R VAS Sbjct: 2482 QRERFIEQEKAK-LEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVAS----------- 2529 Query: 514 GPCTQWLNVRDLDRLQRESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRRQMLAL 573 + + R Q E++ V R Q +L E+ RRQ L Sbjct: 2530 --------MEEARRRQHEAEEGVRRKQEELQ-----------------QLEQQRRQQEEL 2564 Query: 574 ERELDQRRRECQELGAQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVE 633 E +QR RE +L + A E T Q A K NGR A + E Sbjct: 2565 LAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTL----PNGR-DALDGPAAEAE 2619 Query: 634 AENSEVRGHLGRACQERDASGLIAEQLLQQAARGQDRQQQLQR 676 E+S + Q +G+++ + LQ+ A+G +L R Sbjct: 2620 PEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELAR 2662 >gi|41322912 plectin 1 isoform 2 [Homo sapiens] Length = 4533 Score = 73.6 bits (179), Expect = 2e-12 Identities = 206/881 (23%), Positives = 337/881 (38%), Gaps = 164/881 (18%) Query: 25 VLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQ------------- 71 V+ Q E+ R E E RA A++RQ +EEAER RRQ Sbjct: 1442 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1501 Query: 72 -LADRLRSKWEAQRSR--------ELR-QLQEEMQREREAEI---RQLLRWKEAEQRQLQ 118 LA R++++ EA R + ELR Q +E +R R+AE+ RQ+ E QR + Sbjct: 1502 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1561 Query: 119 QLLHRERDGVVRQARELQRQLAEELVN----RGHCSRPGASEVSAAQCRCRLQEVLAQLR 174 L +R + +L+R L EE V R R + A + R + L R Sbjct: 1562 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE--R 1619 Query: 175 WQTDGEQAARIRYLQAALEVERQLFLKYILAHFRGHPA-----LSGSPDPQAVHSLE--- 226 WQ +A R+R LQA EV +Q L A + A G + QAV E Sbjct: 1620 WQLKANEALRLR-LQAE-EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1677 Query: 227 ---EPLPQTSSGSCHAPKPACQLGSLDSLSAEVGVRSRSL------GLVSSACSSSP--- 274 E Q + G+ A Q E G + R L L A +++ Sbjct: 1678 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ 1737 Query: 275 --DGLLSTHASSLDCFAPACSRSLDSTRSLPKASKSEERPSSPDTSTPGSRRLSPPPSPL 332 + L+ + ++ + +R+ + +RS + SK + R L+ + L Sbjct: 1738 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR-----LEAEAGRFRELAEEAARL 1792 Query: 333 PPPPPPSAHRKLSNPRGGEGSESQPCEVLTPSPPGLGHHELIKLNWLLA----KALWVLA 388 + ++ ++ VL +G +K +A +A Sbjct: 1793 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 1852 Query: 389 RRCYTLQA-ENKQLRRAGCPYQADEKVKRLKVKRAELTGLARR--LAD---RARKLQETN 442 RR +A + ++L ++AD + + ++++A + L R+ L + R R+ E Sbjct: 1853 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1912 Query: 443 LRAVSAPIPGESC--AGLELCQVFARQRARDL---SEQASAPLAKDKQI----EELRQEC 493 + A+ A + A LEL R A D EQA A+ +Q+ E R+E Sbjct: 1913 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 1972 Query: 494 HLLQARVASGPCSDLHTGRGGPCTQWLNVRDLDRL-------QRESQREVLRLQRQLMLQ 546 + RV ++ R + +++RL +R +R RQL L Sbjct: 1973 ---EERVQKSLAAEEEAARQRKAA----LEEVERLKAKVEEARRLRERAEQESARQLQLA 2025 Query: 547 QGNGGAWPEAGGQSATCEE------VRRQMLALERELDQRRRECQELGAQAAPARRRGEE 600 Q EA + EE V+++ L++ L Q + +L +A ARR EE Sbjct: 2026 Q-------EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2078 Query: 601 AE--------------------------TQLQAALLKNAWLAEENGRLQAKTDWVRKVEA 634 AE + QA A A E R +A+ + R+ +A Sbjct: 2079 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA 2138 Query: 635 ENSEVRGHLGRACQERDASGLIAEQLLQQAARGQD-----RQQQLQRDPQKALCDLHPSW 689 E + +R A E + AEQ L+Q A+ + R Q + D QK L D Sbjct: 2139 EQAALR-QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD----- 2192 Query: 690 KEIQALQCRPGHPPEQPWETSQMPES------QVKGSRRPKFHARPEDYAVSQPNRD--- 740 +E+Q L+ E + SQ+ E Q++ + K E+ A+ ++D Sbjct: 2193 EELQRLK---AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ 2249 Query: 741 --IQEKREASLEES------PVALGESASVPQVSETVPASQ 773 +QE+ E + + VA E+A + Q++E A Q Sbjct: 2250 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2290 Score = 58.2 bits (139), Expect = 7e-08 Identities = 175/803 (21%), Positives = 304/803 (37%), Gaps = 77/803 (9%) Query: 34 EKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSRELRQLQE 93 E LR E ER AE++R RER EA E+++ ++ +AQ RE ++LQ+ Sbjct: 1325 ETLRRMEEEERL---AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1381 Query: 94 EMQRE---RE---AEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQR---QLAEE-- 142 MQ E RE + +Q R + E +QL+Q E RQA +R ++ EE Sbjct: 1382 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1441 Query: 143 ---LVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAALEVERQLF 199 L + G +E R R +E AQ R E+A R+R Q E +R+ Sbjct: 1442 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQ--EEAERLR-RQVQDESQRKRQ 1498 Query: 200 LKYILAHFRGHPALSGSPDPQAVHSLEEPLPQTSSGSCHAPKPACQLGSLDSLSAEVGVR 259 + LA A + +A+ +LEE Q + + ++ E R Sbjct: 1499 AEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1558 Query: 260 SRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTRSLPKASKSEERPSSP---- 315 S L S S + + + A A R R+ +A R + Sbjct: 1559 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1618 Query: 316 ----DTSTPGSRRLSPPPSPLPPPPPPSAHRKLSNPRGGEGSESQPCEVLTPSPPGLGHH 371 + RL + K E E L Sbjct: 1619 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1678 Query: 372 ELIKLNWL--------LAKALWVLARRCYTLQAENK-----------QLRRAGCPYQADE 412 EL K L LA ++ R T Q E + Q A + E Sbjct: 1679 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1738 Query: 413 KVKRLKVKRAELTGLARRLADRARKLQETNLRAVSAPIPGESCAG--LELCQVFARQRAR 470 L RAE+ L LA +AR +E+ + + E+ AG EL + AR RA Sbjct: 1739 LEAELAKVRAEMEVL---LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1795 Query: 471 DLSEQASAPLAKDKQIEELRQECHLLQARVAS-GPCSDLHTGRGGPCTQWLNVRDLDRLQ 529 + LA++ + + +L ++A+ G + L T + + +RL+ Sbjct: 1796 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE--KEAENERLR 1853 Query: 530 RESQREVLRLQRQLMLQQGNGGAWPE---AGGQSATCEEVRRQMLALERELDQRRRECQE 586 R ++ E + +R+L Q A E A + A+ E+ RQ +E L QRR+ +E Sbjct: 1854 RLAEDEAFQ-RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1912 Query: 587 -LGAQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLGR 645 L +A+ + +AE +L+ +++ + QA+ + R+ + E R R Sbjct: 1913 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR--R 1970 Query: 646 ACQERDASGLIAEQLLQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQALQCRPGHPPEQ 705 +ER L AE+ + A + + ++++R L +E + L+ R + Sbjct: 1971 EAEERVQKSLAAEE--EAARQRKAALEEVER--------LKAKVEEARRLRER-----AE 2015 Query: 706 PWETSQMPESQVKGSRRPKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQV 765 Q+ +Q +R + + +AV Q +++Q+ + GE+ + + Sbjct: 2016 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2075 Query: 766 SETVPASQPLSKKTSSQSNSSSE 788 +E ++ +++ ++QS E Sbjct: 2076 AEEAEEARVQAEREAAQSRRQVE 2098 Score = 54.3 bits (129), Expect = 1e-06 Identities = 59/188 (31%), Positives = 89/188 (47%), Gaps = 24/188 (12%) Query: 23 AAVLENQRRELE-KLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWE 81 AA E +RRE E +++ L AE A R+R AA E R +A+ E A RLR + E Sbjct: 1962 AAEEERRRREAEERVQKSLAAEE---EAARQRKAALEEVERLKAKVEE---ARRLRERAE 2015 Query: 82 AQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGV--VRQARELQRQL 139 + +R+L+ QE Q+ +AE + + ++++LQQ L +E+ + +R E R+ Sbjct: 2016 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2075 Query: 140 AEELVN-RGHCSRPGA--------------SEVSAAQCRCRLQEVLAQLRWQTDGEQAAR 184 AEE R R A S AQ R + Q +LR + + E A R Sbjct: 2076 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2135 Query: 185 IRYLQAAL 192 + QAAL Sbjct: 2136 AQAEQAAL 2143 Score = 50.8 bits (120), Expect = 1e-05 Identities = 52/191 (27%), Positives = 96/191 (50%), Gaps = 23/191 (12%) Query: 24 AVLENQRRELEKLR-AELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEA 82 +VL+ R E E R A EAE A +AER AA+ R+ EEAER ++ ++ +++ +A Sbjct: 2060 SVLDQLRGEAEAARRAAEEAEEARVQAERE--AAQSRRQVEEAERLKQSAEEQAQARAQA 2117 Query: 83 QRSRELRQLQEEMQREREAEIRQ-LLRWKEAEQRQLQQLLHRE-RDGVVRQARELQRQLA 140 Q + E + + E + R A+ Q LR K+A ++++ H++ + +RQ +++++L Sbjct: 2118 QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK--HKKFAEQTLRQKAQVEQELT 2175 Query: 141 E---ELVNRGH--------CSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQ 189 +L H R A AA+ R +++E L +R Q + + L+ Sbjct: 2176 TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME-----ELSKLK 2230 Query: 190 AALEVERQLFL 200 A +E E + + Sbjct: 2231 ARIEAENRALI 2241 Score = 49.3 bits (116), Expect = 3e-05 Identities = 56/186 (30%), Positives = 89/186 (47%), Gaps = 20/186 (10%) Query: 29 QRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSREL 88 Q EL KL+A +EAE + +R L+EEAE+ ++ + R AQ + L Sbjct: 2222 QMEELSKLKARIEAENRALILRDKDNT--QRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2279 Query: 89 RQLQEEMQREREAEIRQLLRWK-----EAEQRQLQ-QLLHRERDGVVRQARELQ------ 136 RQL EE ++ A ++L+ K EA + + + +LL ++++ QAR LQ Sbjct: 2280 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2339 Query: 137 -RQLAEE---LVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAAL 192 +QLAEE R E+SA R +L+ V R Q E+ A+ R+ + A Sbjct: 2340 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR-VAEMSRAQARAEEDAQ-RFRKQAE 2397 Query: 193 EVERQL 198 E+ +L Sbjct: 2398 EIGEKL 2403 Score = 47.4 bits (111), Expect = 1e-04 Identities = 56/204 (27%), Positives = 81/204 (39%), Gaps = 46/204 (22%) Query: 24 AVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQ 83 A L+ + + R ELEAE A RAE A + AE E R +++ + + EA+ Sbjct: 1723 ARLQREAAAATQKRQELEAELAKVRAEMEVLLAS----KARAEEESRSTSEKSKQRLEAE 1778 Query: 84 RSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEEL 143 R R+L EE R R L + QRQL + + RQ E +R LAE+L Sbjct: 1779 AGR-FRELAEEAARLR------ALAEEAKRQRQLAE------EDAARQRAEAERVLAEKL 1825 Query: 144 VNRGHCSRPGAS-----------------------------EVSAAQCRCRLQEVLAQLR 174 G +R E AAQ + ++E LAQLR Sbjct: 1826 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1885 Query: 175 WQTDGEQAARIRYLQAALEVERQL 198 +D E + ++ L RQ+ Sbjct: 1886 KASDSELERQKGLVEDTLRQRRQV 1909 Score = 46.6 bits (109), Expect = 2e-04 Identities = 58/189 (30%), Positives = 90/189 (47%), Gaps = 36/189 (19%) Query: 32 ELEKLRAEL-EAERAGWRAERRRFAARER-----QLREEAERERRQLADRLRSKWEAQR- 84 EL++L+AE EA R + E F+ R + +L+ E E R L LR K QR Sbjct: 2194 ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI--LRDKDNTQRF 2251 Query: 85 ----SRELRQLQEEMQR-----EREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQAREL 135 + +++Q+ EE R + A +RQL A+QR L + + +E+ V++A L Sbjct: 2252 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2311 Query: 136 QRQLAEELVNRGHCSRPGASEVSAAQCRCRLQE----VLAQLRWQTDGEQ----AARIRY 187 + + EL+ + E++ Q R RLQE + QL +T G Q A R R Sbjct: 2312 KAE--AELLQQ-------QKELAQEQAR-RLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2361 Query: 188 LQAALEVER 196 L+ + E ER Sbjct: 2362 LEMSAEAER 2370 Score = 44.7 bits (104), Expect = 8e-04 Identities = 62/184 (33%), Positives = 86/184 (46%), Gaps = 15/184 (8%) Query: 22 AAAVLENQR--RELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSK 79 A A E QR + LE+LR L+AE A R R+ R RQ++ E +R L+SK Sbjct: 1511 AEAAREKQRALQALEELR--LQAEEAE-RRLRQAEVERARQVQVALETAQRSAEAELQSK 1567 Query: 80 WEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQL-LHRERDGVVRQARELQRQ 138 A + + QL+ +Q E A + QL +EAE+R QQ R R+ R+ Q + Sbjct: 1568 -RASFAEKTAQLERSLQEEHVA-VAQLR--EEAERRAQQQAEAERAREEAERELERWQLK 1623 Query: 139 LAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDG---EQAARIRYL-QAALEV 194 E L R A + S AQ Q+ A+ + G EQA R R L + LE Sbjct: 1624 ANEALRLRLQAEEV-AQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK 1682 Query: 195 ERQL 198 +RQL Sbjct: 1683 QRQL 1686 Score = 44.7 bits (104), Expect = 8e-04 Identities = 33/122 (27%), Positives = 67/122 (54%), Gaps = 11/122 (9%) Query: 40 LEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSRELRQLQEEMQRER 99 +E E+A + A+ +QLREE +R+++Q+ E +R R + ++E +R+ Sbjct: 2495 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM--------EQERQRLVASMEEARRRQH 2546 Query: 100 EAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEELVNRGHCSRPGASEVSA 159 EAE + +R K+ E +QL+Q ++ + + + + L+ QL + L + + + EV+A Sbjct: 2547 EAE--EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL-QLLEEQHRAALAHSEEVTA 2603 Query: 160 AQ 161 +Q Sbjct: 2604 SQ 2605 Score = 41.2 bits (95), Expect = 0.008 Identities = 34/125 (27%), Positives = 61/125 (48%), Gaps = 20/125 (16%) Query: 30 RRELEKLRAELEAERAGWRAERRRFAARER------------QLREEAERERRQLADRLR 77 R E + R +AE G + R A +E+ Q +AER R +A+ R Sbjct: 2384 RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER 2443 Query: 78 SKWEAQRSRELRQLQ-EEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQ 136 K + Q+ +L QL+ EEMQ ++ ++ Q E + LQQ E+D ++++ R ++ Sbjct: 2444 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQ-------ETQALQQSFLSEKDSLLQRERFIE 2496 Query: 137 RQLAE 141 ++ A+ Sbjct: 2497 QEKAK 2501 Score = 40.4 bits (93), Expect = 0.014 Identities = 40/140 (28%), Positives = 65/140 (46%), Gaps = 20/140 (14%) Query: 26 LENQRRELEKLRAELEAERAGWRAER----------RRFAARERQLREEAERERRQLADR 75 LE + L+KLRA+ EA++ + A R R R + E ER R ++A + Sbjct: 1111 LEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA-Q 1169 Query: 76 LRSKWEA------QRSRELRQLQEEMQREREA--EIRQLLRWKEAEQRQLQQLLHRERDG 127 L +W+A R REL QL +++ RE+ + L+ Q Q+Q + + Sbjct: 1170 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1229 Query: 128 VVRQARELQRQLAEELVNRG 147 V Q R+ ++ L EE+ G Sbjct: 1230 VREQLRQ-EQALLEEIERHG 1248 Score = 39.7 bits (91), Expect = 0.024 Identities = 42/174 (24%), Positives = 72/174 (41%), Gaps = 7/174 (4%) Query: 24 AVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQ 83 A +E R+ L + A +++R FA + QL + E +A +LR EA+ Sbjct: 1541 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVA-QLRE--EAE 1597 Query: 84 RSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEEL 143 R Q Q E +R RE R+L RW+ L+ L E + + + + +E Sbjct: 1598 RRA---QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1654 Query: 144 VNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAALEVERQ 197 R R G +E A + R ++ L + R +G R+ Q + + + Sbjct: 1655 AER-EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE 1707 Score = 39.7 bits (91), Expect = 0.024 Identities = 53/186 (28%), Positives = 84/186 (45%), Gaps = 16/186 (8%) Query: 23 AAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWE- 81 AA L +E +LR E + A RA + + Q +EA R + + A+ L+ + E Sbjct: 2266 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE-AELLQQQKEL 2324 Query: 82 -AQRSRELRQLQEEMQREREAEIRQLLRWKEAE-QRQLQQLLHRERDGVVRQARELQRQL 139 +++R L++ +E+M ++ E + R EAE QRQL+ ER + + Sbjct: 2325 AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2384 Query: 140 AEELVNRGHCSRPGASEVS--------AAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAA 191 AEE R R A E+ A Q + L + L R Q+D A R+R A Sbjct: 2385 AEEDAQR---FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD-HDAERLREAIAE 2440 Query: 192 LEVERQ 197 LE E++ Sbjct: 2441 LEREKE 2446 Score = 38.5 bits (88), Expect = 0.054 Identities = 35/136 (25%), Positives = 67/136 (49%), Gaps = 20/136 (14%) Query: 26 LENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRS 85 +E ++ +LE+L + A+ R E++R +++Q+ +E +R + + R + EA Sbjct: 2495 IEQEKAKLEQLFQDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEA--- 2548 Query: 86 RELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEELVN 145 EE R ++ E++QL E ++RQ ++LL E + Q + L+ Q L Sbjct: 2549 -------EEGVRRKQEELQQL----EQQRRQQEELLAEENQRLREQLQLLEEQHRAAL-- 2595 Query: 146 RGHCSRPGASEVSAAQ 161 H AS+V+A + Sbjct: 2596 -AHSEEVTASQVAATK 2610 Score = 37.7 bits (86), Expect = 0.092 Identities = 34/124 (27%), Positives = 55/124 (44%), Gaps = 34/124 (27%) Query: 103 IRQLLRWKEAEQRQLQQLLHRERDGVV------------------------RQARELQRQ 138 I + LR E E+R +Q ER+ + R+A+ELQ++ Sbjct: 1323 ISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR 1382 Query: 139 LAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAA----LEV 194 + EE+V R + V A Q + +QE L QLR ++ E A+ R +AA L + Sbjct: 1383 MQEEVVRREEAA------VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1436 Query: 195 ERQL 198 E ++ Sbjct: 1437 EEEI 1440 Score = 37.7 bits (86), Expect = 0.092 Identities = 58/251 (23%), Positives = 109/251 (43%), Gaps = 42/251 (16%) Query: 393 TLQAENKQLRRAGCPYQADEKVKRLKVKRAELTGL-------ARRLADRARKLQETNLRA 445 TL+AE ++ + + +RLK++ AE++ A+R +A ++ E R Sbjct: 2353 TLEAERQR------QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2406 Query: 446 VSAPIPGESCAGLELCQVFARQRARDLSEQASAPLAKDKQIEELRQECHLLQARVASGPC 505 A E ++ ++ +Q D A +++ E+L+QE LLQ + Sbjct: 2407 ELAT--QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK-----S 2459 Query: 506 SDLHTGRGGPCTQWLNVRDLDRLQRE--SQREVLRLQRQLMLQQGNGGAWPEAGGQSATC 563 ++ T + Q +++ LQ+ S+++ L LQR+ ++Q + A Sbjct: 2460 EEMQTVQ-----QEQLLQETQALQQSFLSEKDSL-LQRERFIEQEKAKLEQLFQDEVAKA 2513 Query: 564 EEVRRQMLALERELDQRRRECQELGAQAAPARRRGEEAETQL-----------QAALLKN 612 +++R + +++++Q R Q L A ARRR EAE + Q + Sbjct: 2514 QQLREEQQRQQQQMEQER---QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE 2570 Query: 613 AWLAEENGRLQ 623 LAEEN RL+ Sbjct: 2571 ELLAEENQRLR 2581 Score = 37.7 bits (86), Expect = 0.092 Identities = 38/136 (27%), Positives = 71/136 (52%), Gaps = 16/136 (11%) Query: 26 LENQRRE----LEKLR---AELEAERAGWRAERRRFAARERQLR----EEAERERRQLAD 74 LE QR++ E+LR AELE E+ + E + + +++ E+ +E + L Sbjct: 2420 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2479 Query: 75 RLRSKWEA--QRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQA 132 S+ ++ QR R + Q + ++++ + E+ + + +E +QRQ QQ + +ER +V Sbjct: 2480 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ-QQQMEQERQRLVASM 2538 Query: 133 RELQRQL--AEELVNR 146 E +R+ AEE V R Sbjct: 2539 EEARRRQHEAEEGVRR 2554 Score = 36.6 bits (83), Expect = 0.21 Identities = 55/186 (29%), Positives = 82/186 (44%), Gaps = 23/186 (12%) Query: 23 AAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERE--RRQLADR--LRS 78 AA Q E E+L+ E E+A RA+ + A +LR+EAE+E RR A++ LR Sbjct: 2090 AAQSRRQVEEAERLKQSAE-EQAQARAQAQ---AAAEKLRKEAEQEAARRAQAEQAALRQ 2145 Query: 79 KWEAQRSRELRQLQEEMQREREAEIRQ---LLRWKEAEQRQLQQLLHRERDGVVRQAREL 135 K A E + E ++A++ Q LR + E + LL E + +A E Sbjct: 2146 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2205 Query: 136 QR---QLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAAL 192 R Q+ EEL + R E+S + R + LR D Q R+LQ Sbjct: 2206 ARQRSQVEEELFS----VRVQMEELSKLKARIEAENRALILR-DKDNTQ----RFLQEEA 2256 Query: 193 EVERQL 198 E +Q+ Sbjct: 2257 EKMKQV 2262 Score = 33.1 bits (74), Expect = 2.3 Identities = 34/121 (28%), Positives = 52/121 (42%), Gaps = 12/121 (9%) Query: 22 AAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLR------EEAERERRQLADR 75 A + E Q+R+ +++ E + A RRR E +R ++ E++RRQ + Sbjct: 2513 AQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL 2572 Query: 76 LRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQAREL 135 L E QR RE QL EE R A ++ A Q + L RD + A E Sbjct: 2573 LAE--ENQRLREQLQLLEEQHRAALAHSEEV----TASQVAATKTLPNGRDALDGPAAEA 2626 Query: 136 Q 136 + Sbjct: 2627 E 2627 Score = 31.2 bits (69), Expect = 8.6 Identities = 64/283 (22%), Positives = 112/283 (39%), Gaps = 49/283 (17%) Query: 399 KQLRRAGCPYQADEKVKRLKVKRAELTGLARRLADRARKLQETNLRAVSAPIPGESCAGL 458 ++LR A + +++ + + K +L + + + LQET +A+ E + L Sbjct: 2432 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQET--QALQQSFLSEKDSLL 2489 Query: 459 ELCQVFARQRARDLSEQASAPLAKDKQI--EELRQECHLLQAR---VASGPCSDLHTGRG 513 + + +++A+ L + +AK +Q+ E+ RQ+ + Q R VAS Sbjct: 2490 QRERFIEQEKAK-LEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVAS----------- 2537 Query: 514 GPCTQWLNVRDLDRLQRESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRRQMLAL 573 + + R Q E++ V R Q +L E+ RRQ L Sbjct: 2538 --------MEEARRRQHEAEEGVRRKQEELQ-----------------QLEQQRRQQEEL 2572 Query: 574 ERELDQRRRECQELGAQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVE 633 E +QR RE +L + A E T Q A K NGR A + E Sbjct: 2573 LAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTL----PNGR-DALDGPAAEAE 2627 Query: 634 AENSEVRGHLGRACQERDASGLIAEQLLQQAARGQDRQQQLQR 676 E+S + Q +G+++ + LQ+ A+G +L R Sbjct: 2628 PEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELAR 2670 >gi|47607492 plectin 1 isoform 1 [Homo sapiens] Length = 4574 Score = 73.6 bits (179), Expect = 2e-12 Identities = 206/881 (23%), Positives = 337/881 (38%), Gaps = 164/881 (18%) Query: 25 VLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQ------------- 71 V+ Q E+ R E E RA A++RQ +EEAER RRQ Sbjct: 1483 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1542 Query: 72 -LADRLRSKWEAQRSR--------ELR-QLQEEMQREREAEI---RQLLRWKEAEQRQLQ 118 LA R++++ EA R + ELR Q +E +R R+AE+ RQ+ E QR + Sbjct: 1543 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1602 Query: 119 QLLHRERDGVVRQARELQRQLAEELVN----RGHCSRPGASEVSAAQCRCRLQEVLAQLR 174 L +R + +L+R L EE V R R + A + R + L R Sbjct: 1603 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE--R 1660 Query: 175 WQTDGEQAARIRYLQAALEVERQLFLKYILAHFRGHPA-----LSGSPDPQAVHSLE--- 226 WQ +A R+R LQA EV +Q L A + A G + QAV E Sbjct: 1661 WQLKANEALRLR-LQAE-EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1718 Query: 227 ---EPLPQTSSGSCHAPKPACQLGSLDSLSAEVGVRSRSL------GLVSSACSSSP--- 274 E Q + G+ A Q E G + R L L A +++ Sbjct: 1719 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ 1778 Query: 275 --DGLLSTHASSLDCFAPACSRSLDSTRSLPKASKSEERPSSPDTSTPGSRRLSPPPSPL 332 + L+ + ++ + +R+ + +RS + SK + R L+ + L Sbjct: 1779 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR-----LEAEAGRFRELAEEAARL 1833 Query: 333 PPPPPPSAHRKLSNPRGGEGSESQPCEVLTPSPPGLGHHELIKLNWLLA----KALWVLA 388 + ++ ++ VL +G +K +A +A Sbjct: 1834 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 1893 Query: 389 RRCYTLQA-ENKQLRRAGCPYQADEKVKRLKVKRAELTGLARR--LAD---RARKLQETN 442 RR +A + ++L ++AD + + ++++A + L R+ L + R R+ E Sbjct: 1894 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1953 Query: 443 LRAVSAPIPGESC--AGLELCQVFARQRARDL---SEQASAPLAKDKQI----EELRQEC 493 + A+ A + A LEL R A D EQA A+ +Q+ E R+E Sbjct: 1954 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 2013 Query: 494 HLLQARVASGPCSDLHTGRGGPCTQWLNVRDLDRL-------QRESQREVLRLQRQLMLQ 546 + RV ++ R + +++RL +R +R RQL L Sbjct: 2014 ---EERVQKSLAAEEEAARQRKAA----LEEVERLKAKVEEARRLRERAEQESARQLQLA 2066 Query: 547 QGNGGAWPEAGGQSATCEE------VRRQMLALERELDQRRRECQELGAQAAPARRRGEE 600 Q EA + EE V+++ L++ L Q + +L +A ARR EE Sbjct: 2067 Q-------EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2119 Query: 601 AE--------------------------TQLQAALLKNAWLAEENGRLQAKTDWVRKVEA 634 AE + QA A A E R +A+ + R+ +A Sbjct: 2120 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA 2179 Query: 635 ENSEVRGHLGRACQERDASGLIAEQLLQQAARGQD-----RQQQLQRDPQKALCDLHPSW 689 E + +R A E + AEQ L+Q A+ + R Q + D QK L D Sbjct: 2180 EQAALR-QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD----- 2233 Query: 690 KEIQALQCRPGHPPEQPWETSQMPES------QVKGSRRPKFHARPEDYAVSQPNRD--- 740 +E+Q L+ E + SQ+ E Q++ + K E+ A+ ++D Sbjct: 2234 EELQRLK---AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ 2290 Query: 741 --IQEKREASLEES------PVALGESASVPQVSETVPASQ 773 +QE+ E + + VA E+A + Q++E A Q Sbjct: 2291 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2331 Score = 58.2 bits (139), Expect = 7e-08 Identities = 175/803 (21%), Positives = 304/803 (37%), Gaps = 77/803 (9%) Query: 34 EKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSRELRQLQE 93 E LR E ER AE++R RER EA E+++ ++ +AQ RE ++LQ+ Sbjct: 1366 ETLRRMEEEERL---AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1422 Query: 94 EMQRE---RE---AEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQR---QLAEE-- 142 MQ E RE + +Q R + E +QL+Q E RQA +R ++ EE Sbjct: 1423 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1482 Query: 143 ---LVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAALEVERQLF 199 L + G +E R R +E AQ R E+A R+R Q E +R+ Sbjct: 1483 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQ--EEAERLR-RQVQDESQRKRQ 1539 Query: 200 LKYILAHFRGHPALSGSPDPQAVHSLEEPLPQTSSGSCHAPKPACQLGSLDSLSAEVGVR 259 + LA A + +A+ +LEE Q + + ++ E R Sbjct: 1540 AEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1599 Query: 260 SRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTRSLPKASKSEERPSSP---- 315 S L S S + + + A A R R+ +A R + Sbjct: 1600 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1659 Query: 316 ----DTSTPGSRRLSPPPSPLPPPPPPSAHRKLSNPRGGEGSESQPCEVLTPSPPGLGHH 371 + RL + K E E L Sbjct: 1660 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1719 Query: 372 ELIKLNWL--------LAKALWVLARRCYTLQAENK-----------QLRRAGCPYQADE 412 EL K L LA ++ R T Q E + Q A + E Sbjct: 1720 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1779 Query: 413 KVKRLKVKRAELTGLARRLADRARKLQETNLRAVSAPIPGESCAG--LELCQVFARQRAR 470 L RAE+ L LA +AR +E+ + + E+ AG EL + AR RA Sbjct: 1780 LEAELAKVRAEMEVL---LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1836 Query: 471 DLSEQASAPLAKDKQIEELRQECHLLQARVAS-GPCSDLHTGRGGPCTQWLNVRDLDRLQ 529 + LA++ + + +L ++A+ G + L T + + +RL+ Sbjct: 1837 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE--KEAENERLR 1894 Query: 530 RESQREVLRLQRQLMLQQGNGGAWPE---AGGQSATCEEVRRQMLALERELDQRRRECQE 586 R ++ E + +R+L Q A E A + A+ E+ RQ +E L QRR+ +E Sbjct: 1895 RLAEDEAFQ-RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1953 Query: 587 -LGAQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLGR 645 L +A+ + +AE +L+ +++ + QA+ + R+ + E R R Sbjct: 1954 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR--R 2011 Query: 646 ACQERDASGLIAEQLLQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQALQCRPGHPPEQ 705 +ER L AE+ + A + + ++++R L +E + L+ R + Sbjct: 2012 EAEERVQKSLAAEE--EAARQRKAALEEVER--------LKAKVEEARRLRER-----AE 2056 Query: 706 PWETSQMPESQVKGSRRPKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQV 765 Q+ +Q +R + + +AV Q +++Q+ + GE+ + + Sbjct: 2057 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2116 Query: 766 SETVPASQPLSKKTSSQSNSSSE 788 +E ++ +++ ++QS E Sbjct: 2117 AEEAEEARVQAEREAAQSRRQVE 2139 Score = 54.3 bits (129), Expect = 1e-06 Identities = 59/188 (31%), Positives = 89/188 (47%), Gaps = 24/188 (12%) Query: 23 AAVLENQRRELE-KLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWE 81 AA E +RRE E +++ L AE A R+R AA E R +A+ E A RLR + E Sbjct: 2003 AAEEERRRREAEERVQKSLAAEE---EAARQRKAALEEVERLKAKVEE---ARRLRERAE 2056 Query: 82 AQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGV--VRQARELQRQL 139 + +R+L+ QE Q+ +AE + + ++++LQQ L +E+ + +R E R+ Sbjct: 2057 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2116 Query: 140 AEELVN-RGHCSRPGA--------------SEVSAAQCRCRLQEVLAQLRWQTDGEQAAR 184 AEE R R A S AQ R + Q +LR + + E A R Sbjct: 2117 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2176 Query: 185 IRYLQAAL 192 + QAAL Sbjct: 2177 AQAEQAAL 2184 Score = 50.8 bits (120), Expect = 1e-05 Identities = 52/191 (27%), Positives = 96/191 (50%), Gaps = 23/191 (12%) Query: 24 AVLENQRRELEKLR-AELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEA 82 +VL+ R E E R A EAE A +AER AA+ R+ EEAER ++ ++ +++ +A Sbjct: 2101 SVLDQLRGEAEAARRAAEEAEEARVQAERE--AAQSRRQVEEAERLKQSAEEQAQARAQA 2158 Query: 83 QRSRELRQLQEEMQREREAEIRQ-LLRWKEAEQRQLQQLLHRE-RDGVVRQARELQRQLA 140 Q + E + + E + R A+ Q LR K+A ++++ H++ + +RQ +++++L Sbjct: 2159 QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK--HKKFAEQTLRQKAQVEQELT 2216 Query: 141 E---ELVNRGH--------CSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQ 189 +L H R A AA+ R +++E L +R Q + + L+ Sbjct: 2217 TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME-----ELSKLK 2271 Query: 190 AALEVERQLFL 200 A +E E + + Sbjct: 2272 ARIEAENRALI 2282 Score = 49.3 bits (116), Expect = 3e-05 Identities = 56/186 (30%), Positives = 89/186 (47%), Gaps = 20/186 (10%) Query: 29 QRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSREL 88 Q EL KL+A +EAE + +R L+EEAE+ ++ + R AQ + L Sbjct: 2263 QMEELSKLKARIEAENRALILRDKDNT--QRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2320 Query: 89 RQLQEEMQREREAEIRQLLRWK-----EAEQRQLQ-QLLHRERDGVVRQARELQ------ 136 RQL EE ++ A ++L+ K EA + + + +LL ++++ QAR LQ Sbjct: 2321 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2380 Query: 137 -RQLAEE---LVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAAL 192 +QLAEE R E+SA R +L+ V R Q E+ A+ R+ + A Sbjct: 2381 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR-VAEMSRAQARAEEDAQ-RFRKQAE 2438 Query: 193 EVERQL 198 E+ +L Sbjct: 2439 EIGEKL 2444 Score = 47.4 bits (111), Expect = 1e-04 Identities = 56/204 (27%), Positives = 81/204 (39%), Gaps = 46/204 (22%) Query: 24 AVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQ 83 A L+ + + R ELEAE A RAE A + AE E R +++ + + EA+ Sbjct: 1764 ARLQREAAAATQKRQELEAELAKVRAEMEVLLAS----KARAEEESRSTSEKSKQRLEAE 1819 Query: 84 RSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEEL 143 R R+L EE R R L + QRQL + + RQ E +R LAE+L Sbjct: 1820 AGR-FRELAEEAARLR------ALAEEAKRQRQLAE------EDAARQRAEAERVLAEKL 1866 Query: 144 VNRGHCSRPGAS-----------------------------EVSAAQCRCRLQEVLAQLR 174 G +R E AAQ + ++E LAQLR Sbjct: 1867 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1926 Query: 175 WQTDGEQAARIRYLQAALEVERQL 198 +D E + ++ L RQ+ Sbjct: 1927 KASDSELERQKGLVEDTLRQRRQV 1950 Score = 46.6 bits (109), Expect = 2e-04 Identities = 58/189 (30%), Positives = 90/189 (47%), Gaps = 36/189 (19%) Query: 32 ELEKLRAEL-EAERAGWRAERRRFAARER-----QLREEAERERRQLADRLRSKWEAQR- 84 EL++L+AE EA R + E F+ R + +L+ E E R L LR K QR Sbjct: 2235 ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI--LRDKDNTQRF 2292 Query: 85 ----SRELRQLQEEMQR-----EREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQAREL 135 + +++Q+ EE R + A +RQL A+QR L + + +E+ V++A L Sbjct: 2293 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2352 Query: 136 QRQLAEELVNRGHCSRPGASEVSAAQCRCRLQE----VLAQLRWQTDGEQ----AARIRY 187 + + EL+ + E++ Q R RLQE + QL +T G Q A R R Sbjct: 2353 KAE--AELLQQ-------QKELAQEQAR-RLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2402 Query: 188 LQAALEVER 196 L+ + E ER Sbjct: 2403 LEMSAEAER 2411 Score = 44.7 bits (104), Expect = 8e-04 Identities = 62/184 (33%), Positives = 86/184 (46%), Gaps = 15/184 (8%) Query: 22 AAAVLENQR--RELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSK 79 A A E QR + LE+LR L+AE A R R+ R RQ++ E +R L+SK Sbjct: 1552 AEAAREKQRALQALEELR--LQAEEAE-RRLRQAEVERARQVQVALETAQRSAEAELQSK 1608 Query: 80 WEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQL-LHRERDGVVRQARELQRQ 138 A + + QL+ +Q E A + QL +EAE+R QQ R R+ R+ Q + Sbjct: 1609 -RASFAEKTAQLERSLQEEHVA-VAQLR--EEAERRAQQQAEAERAREEAERELERWQLK 1664 Query: 139 LAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDG---EQAARIRYL-QAALEV 194 E L R A + S AQ Q+ A+ + G EQA R R L + LE Sbjct: 1665 ANEALRLRLQAEEV-AQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK 1723 Query: 195 ERQL 198 +RQL Sbjct: 1724 QRQL 1727 Score = 44.7 bits (104), Expect = 8e-04 Identities = 33/122 (27%), Positives = 67/122 (54%), Gaps = 11/122 (9%) Query: 40 LEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSRELRQLQEEMQRER 99 +E E+A + A+ +QLREE +R+++Q+ E +R R + ++E +R+ Sbjct: 2536 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM--------EQERQRLVASMEEARRRQH 2587 Query: 100 EAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEELVNRGHCSRPGASEVSA 159 EAE + +R K+ E +QL+Q ++ + + + + L+ QL + L + + + EV+A Sbjct: 2588 EAE--EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL-QLLEEQHRAALAHSEEVTA 2644 Query: 160 AQ 161 +Q Sbjct: 2645 SQ 2646 Score = 41.2 bits (95), Expect = 0.008 Identities = 34/125 (27%), Positives = 61/125 (48%), Gaps = 20/125 (16%) Query: 30 RRELEKLRAELEAERAGWRAERRRFAARER------------QLREEAERERRQLADRLR 77 R E + R +AE G + R A +E+ Q +AER R +A+ R Sbjct: 2425 RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER 2484 Query: 78 SKWEAQRSRELRQLQ-EEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQ 136 K + Q+ +L QL+ EEMQ ++ ++ Q E + LQQ E+D ++++ R ++ Sbjct: 2485 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQ-------ETQALQQSFLSEKDSLLQRERFIE 2537 Query: 137 RQLAE 141 ++ A+ Sbjct: 2538 QEKAK 2542 Score = 40.4 bits (93), Expect = 0.014 Identities = 40/140 (28%), Positives = 65/140 (46%), Gaps = 20/140 (14%) Query: 26 LENQRRELEKLRAELEAERAGWRAER----------RRFAARERQLREEAERERRQLADR 75 LE + L+KLRA+ EA++ + A R R R + E ER R ++A + Sbjct: 1152 LEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA-Q 1210 Query: 76 LRSKWEA------QRSRELRQLQEEMQREREA--EIRQLLRWKEAEQRQLQQLLHRERDG 127 L +W+A R REL QL +++ RE+ + L+ Q Q+Q + + Sbjct: 1211 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1270 Query: 128 VVRQARELQRQLAEELVNRG 147 V Q R+ ++ L EE+ G Sbjct: 1271 VREQLRQ-EQALLEEIERHG 1289 Score = 39.7 bits (91), Expect = 0.024 Identities = 42/174 (24%), Positives = 72/174 (41%), Gaps = 7/174 (4%) Query: 24 AVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQ 83 A +E R+ L + A +++R FA + QL + E +A +LR EA+ Sbjct: 1582 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVA-QLRE--EAE 1638 Query: 84 RSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEEL 143 R Q Q E +R RE R+L RW+ L+ L E + + + + +E Sbjct: 1639 RRA---QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1695 Query: 144 VNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAALEVERQ 197 R R G +E A + R ++ L + R +G R+ Q + + + Sbjct: 1696 AER-EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE 1748 Score = 39.7 bits (91), Expect = 0.024 Identities = 53/186 (28%), Positives = 84/186 (45%), Gaps = 16/186 (8%) Query: 23 AAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWE- 81 AA L +E +LR E + A RA + + Q +EA R + + A+ L+ + E Sbjct: 2307 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE-AELLQQQKEL 2365 Query: 82 -AQRSRELRQLQEEMQREREAEIRQLLRWKEAE-QRQLQQLLHRERDGVVRQARELQRQL 139 +++R L++ +E+M ++ E + R EAE QRQL+ ER + + Sbjct: 2366 AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2425 Query: 140 AEELVNRGHCSRPGASEVS--------AAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAA 191 AEE R R A E+ A Q + L + L R Q+D A R+R A Sbjct: 2426 AEEDAQR---FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD-HDAERLREAIAE 2481 Query: 192 LEVERQ 197 LE E++ Sbjct: 2482 LEREKE 2487 Score = 38.5 bits (88), Expect = 0.054 Identities = 35/136 (25%), Positives = 67/136 (49%), Gaps = 20/136 (14%) Query: 26 LENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRS 85 +E ++ +LE+L + A+ R E++R +++Q+ +E +R + + R + EA Sbjct: 2536 IEQEKAKLEQLFQDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEA--- 2589 Query: 86 RELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEELVN 145 EE R ++ E++QL E ++RQ ++LL E + Q + L+ Q L Sbjct: 2590 -------EEGVRRKQEELQQL----EQQRRQQEELLAEENQRLREQLQLLEEQHRAAL-- 2636 Query: 146 RGHCSRPGASEVSAAQ 161 H AS+V+A + Sbjct: 2637 -AHSEEVTASQVAATK 2651 Score = 37.7 bits (86), Expect = 0.092 Identities = 34/124 (27%), Positives = 55/124 (44%), Gaps = 34/124 (27%) Query: 103 IRQLLRWKEAEQRQLQQLLHRERDGVV------------------------RQARELQRQ 138 I + LR E E+R +Q ER+ + R+A+ELQ++ Sbjct: 1364 ISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR 1423 Query: 139 LAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAA----LEV 194 + EE+V R + V A Q + +QE L QLR ++ E A+ R +AA L + Sbjct: 1424 MQEEVVRREEAA------VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1477 Query: 195 ERQL 198 E ++ Sbjct: 1478 EEEI 1481 Score = 37.7 bits (86), Expect = 0.092 Identities = 58/251 (23%), Positives = 109/251 (43%), Gaps = 42/251 (16%) Query: 393 TLQAENKQLRRAGCPYQADEKVKRLKVKRAELTGL-------ARRLADRARKLQETNLRA 445 TL+AE ++ + + +RLK++ AE++ A+R +A ++ E R Sbjct: 2394 TLEAERQR------QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2447 Query: 446 VSAPIPGESCAGLELCQVFARQRARDLSEQASAPLAKDKQIEELRQECHLLQARVASGPC 505 A E ++ ++ +Q D A +++ E+L+QE LLQ + Sbjct: 2448 ELAT--QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK-----S 2500 Query: 506 SDLHTGRGGPCTQWLNVRDLDRLQRE--SQREVLRLQRQLMLQQGNGGAWPEAGGQSATC 563 ++ T + Q +++ LQ+ S+++ L LQR+ ++Q + A Sbjct: 2501 EEMQTVQ-----QEQLLQETQALQQSFLSEKDSL-LQRERFIEQEKAKLEQLFQDEVAKA 2554 Query: 564 EEVRRQMLALERELDQRRRECQELGAQAAPARRRGEEAETQL-----------QAALLKN 612 +++R + +++++Q R Q L A ARRR EAE + Q + Sbjct: 2555 QQLREEQQRQQQQMEQER---QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE 2611 Query: 613 AWLAEENGRLQ 623 LAEEN RL+ Sbjct: 2612 ELLAEENQRLR 2622 Score = 37.7 bits (86), Expect = 0.092 Identities = 38/136 (27%), Positives = 71/136 (52%), Gaps = 16/136 (11%) Query: 26 LENQRRE----LEKLR---AELEAERAGWRAERRRFAARERQLR----EEAERERRQLAD 74 LE QR++ E+LR AELE E+ + E + + +++ E+ +E + L Sbjct: 2461 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2520 Query: 75 RLRSKWEA--QRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQA 132 S+ ++ QR R + Q + ++++ + E+ + + +E +QRQ QQ + +ER +V Sbjct: 2521 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ-QQQMEQERQRLVASM 2579 Query: 133 RELQRQL--AEELVNR 146 E +R+ AEE V R Sbjct: 2580 EEARRRQHEAEEGVRR 2595 Score = 36.6 bits (83), Expect = 0.21 Identities = 55/186 (29%), Positives = 82/186 (44%), Gaps = 23/186 (12%) Query: 23 AAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERE--RRQLADR--LRS 78 AA Q E E+L+ E E+A RA+ + A +LR+EAE+E RR A++ LR Sbjct: 2131 AAQSRRQVEEAERLKQSAE-EQAQARAQAQ---AAAEKLRKEAEQEAARRAQAEQAALRQ 2186 Query: 79 KWEAQRSRELRQLQEEMQREREAEIRQ---LLRWKEAEQRQLQQLLHRERDGVVRQAREL 135 K A E + E ++A++ Q LR + E + LL E + +A E Sbjct: 2187 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2246 Query: 136 QR---QLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAAL 192 R Q+ EEL + R E+S + R + LR D Q R+LQ Sbjct: 2247 ARQRSQVEEELFS----VRVQMEELSKLKARIEAENRALILR-DKDNTQ----RFLQEEA 2297 Query: 193 EVERQL 198 E +Q+ Sbjct: 2298 EKMKQV 2303 Score = 33.1 bits (74), Expect = 2.3 Identities = 34/121 (28%), Positives = 52/121 (42%), Gaps = 12/121 (9%) Query: 22 AAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLR------EEAERERRQLADR 75 A + E Q+R+ +++ E + A RRR E +R ++ E++RRQ + Sbjct: 2554 AQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL 2613 Query: 76 LRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQAREL 135 L E QR RE QL EE R A ++ A Q + L RD + A E Sbjct: 2614 LAE--ENQRLREQLQLLEEQHRAALAHSEEV----TASQVAATKTLPNGRDALDGPAAEA 2667 Query: 136 Q 136 + Sbjct: 2668 E 2668 Score = 31.2 bits (69), Expect = 8.6 Identities = 64/283 (22%), Positives = 112/283 (39%), Gaps = 49/283 (17%) Query: 399 KQLRRAGCPYQADEKVKRLKVKRAELTGLARRLADRARKLQETNLRAVSAPIPGESCAGL 458 ++LR A + +++ + + K +L + + + LQET +A+ E + L Sbjct: 2473 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQET--QALQQSFLSEKDSLL 2530 Query: 459 ELCQVFARQRARDLSEQASAPLAKDKQI--EELRQECHLLQAR---VASGPCSDLHTGRG 513 + + +++A+ L + +AK +Q+ E+ RQ+ + Q R VAS Sbjct: 2531 QRERFIEQEKAK-LEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVAS----------- 2578 Query: 514 GPCTQWLNVRDLDRLQRESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRRQMLAL 573 + + R Q E++ V R Q +L E+ RRQ L Sbjct: 2579 --------MEEARRRQHEAEEGVRRKQEELQ-----------------QLEQQRRQQEEL 2613 Query: 574 ERELDQRRRECQELGAQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVE 633 E +QR RE +L + A E T Q A K NGR A + E Sbjct: 2614 LAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTL----PNGR-DALDGPAAEAE 2668 Query: 634 AENSEVRGHLGRACQERDASGLIAEQLLQQAARGQDRQQQLQR 676 E+S + Q +G+++ + LQ+ A+G +L R Sbjct: 2669 PEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELAR 2711 >gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4 isoform 1 [Homo sapiens] Length = 1166 Score = 72.0 bits (175), Expect = 4e-12 Identities = 97/337 (28%), Positives = 144/337 (42%), Gaps = 47/337 (13%) Query: 30 RRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSRELR 89 RR+ +L+ E ER+ A RR+ +E+QLRE+ E +R+ LA+ R K Q+ + R Sbjct: 353 RRDFLRLQQE-NKERS--EALRRQQLLQEQQLREQEEYKRQLLAE--RQKRIEQQKEQRR 407 Query: 90 QLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEELVNRGHC 149 +L+E+ +REREA R +E EQR+ +Q E+ R+ EL+R+ EE R Sbjct: 408 RLEEQQRREREAR-----RQQEREQRRREQ---EEK----RRLEELERRRKEEEERR--- 452 Query: 150 SRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAALEVERQLFLKYILAHFRG 209 A + + R++ +R Q + EQ + LQ L E+ + L H R Sbjct: 453 --------RAEEEKRRVEREQEYIRRQLEEEQ-RHLEVLQQQLLQEQAMLLH---DHRRP 500 Query: 210 HPALSGSPDPQAVHSLEEPLPQTSSGSCHAPKPACQLGSLDSLSAEVGVRSRSLGLVSSA 269 HP S P P P + S S HAP+P D + EV VR+ S V S Sbjct: 501 HPQHSQQPPP--------PQQERSKPSFHAPEPKAHYEPADR-AREVPVRTTSRSPVLSR 551 Query: 270 CSSSPDGLLSTHASSLDCFAPACSRSLDSTRSLPKASKSEERPSSPDTSTPGSRRLSPPP 329 S G + + + S++ + K RP S +S GS P Sbjct: 552 RDSPLQG---SGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSS--GSSNSGSQP 606 Query: 330 SPLPPPPPPSAHR-KLSNPRGGEGSESQPCEVLTPSP 365 P S R ++ + EGS SQ E P Sbjct: 607 GSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKP 643 Score = 46.6 bits (109), Expect = 2e-04 Identities = 40/104 (38%), Positives = 57/104 (54%), Gaps = 13/104 (12%) Query: 27 ENQRREL-EKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRS 85 + QRR L E+ R E EA R R +RRR +R+L EE ER R++ +R R++ + Sbjct: 403 KEQRRRLEEQQRREREARRQQEREQRRREQEEKRRL-EELERRRKEEEERRRAE---EEK 458 Query: 86 RELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQ----LLHRER 125 R + + QE ++R+ E E R L E Q+QL Q LLH R Sbjct: 459 RRVEREQEYIRRQLEEEQRHL----EVLQQQLLQEQAMLLHDHR 498 Score = 38.9 bits (89), Expect = 0.041 Identities = 79/310 (25%), Positives = 117/310 (37%), Gaps = 102/310 (32%) Query: 523 RDLDRLQRESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRRQMLA---------- 572 RD RLQ+E++ L+RQ +LQ+ Q EE +RQ+LA Sbjct: 354 RDFLRLQQENKERSEALRRQQLLQEQ----------QLREQEEYKRQLLAERQKRIEQQK 403 Query: 573 -----------------LERELDQRRRECQELGAQAAPARRRGEEAETQLQAALLKNAWL 615 ++E +QRRRE +E +RR EE E + + Sbjct: 404 EQRRRLEEQQRREREARRQQEREQRRREQEE--------KRRLEELERRRK--------- 446 Query: 616 AEENGRLQAKTDWVRKVEAENSEVRGHLGRACQERDASGLIAEQLLQQAARGQDRQQQLQ 675 EE R +A+ + R+VE E +R L +E+ ++ +QLLQ+ Q L Sbjct: 447 -EEEERRRAEEE-KRRVEREQEYIRRQLE---EEQRHLEVLQQQLLQE-------QAMLL 494 Query: 676 RDPQKALCDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQVKGSRRPKFHARPEDYAVS 735 D ++ HP Q Q P E+ + PE PK H P D A Sbjct: 495 HDHRRP----HP-----QHSQQPPPPQQERSKPSFHAPE--------PKAHYEPADRARE 537 Query: 736 QPNRDIQEKREASLEESPV--------ALGESASV---------PQVSETVPASQPLSKK 778 P R S +SP+ G+ S +V + VP +P S Sbjct: 538 VPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVP--RPGSGS 595 Query: 779 TSSQSNSSSE 788 +S SNS S+ Sbjct: 596 SSGSSNSGSQ 605 >gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4 isoform 3 [Homo sapiens] Length = 1212 Score = 70.5 bits (171), Expect = 1e-11 Identities = 91/305 (29%), Positives = 135/305 (44%), Gaps = 49/305 (16%) Query: 30 RRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSRELR 89 RR+ +L+ E ER+ A RR+ +E+QLRE+ E +R+ LA+ R K Q+ + R Sbjct: 353 RRDFLRLQQE-NKERS--EALRRQQLLQEQQLREQEEYKRQLLAE--RQKRIEQQKEQRR 407 Query: 90 QLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEELVNRGHC 149 +L+E+ +REREA R +E EQR+ +Q E+ R+ EL+R+ EE R Sbjct: 408 RLEEQQRREREAR-----RQQEREQRRREQ---EEK----RRLEELERRRKEEEERR--- 452 Query: 150 SRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAALEVERQLFLKYILAHFRG 209 A + + R++ +R Q + EQ + LQ L E+ + L H R Sbjct: 453 --------RAEEEKRRVEREQEYIRRQLEEEQ-RHLEVLQQQLLQEQAMLLH---DHRRP 500 Query: 210 HPALSGSPDPQAVHSLEEPLPQTSSGSCHAPKPACQLGSLDSLSAEVGVRSRSLGLVSSA 269 HP S P P P + S S HAP+P D + EV R R Sbjct: 501 HPQHSQQPPP--------PQQERSKPSFHAPEPKAHYEPADR-AREVEDRFRKTN----- 546 Query: 270 CSSSPDGLLSTHASSLDCFAPACSRSLD--STRSLPKASKSEERPSSPDTSTPGSRRLSP 327 SSP+ L+ P+ S S ++ S+ A + P P +T S LS Sbjct: 547 -HSSPEAQSKQTGRVLEPPVPSRSESFSNGNSESVHPALQRPAEPQVPVRTTSRSPVLSR 605 Query: 328 PPSPL 332 SPL Sbjct: 606 RDSPL 610 Score = 46.6 bits (109), Expect = 2e-04 Identities = 40/104 (38%), Positives = 57/104 (54%), Gaps = 13/104 (12%) Query: 27 ENQRREL-EKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRS 85 + QRR L E+ R E EA R R +RRR +R+L EE ER R++ +R R++ + Sbjct: 403 KEQRRRLEEQQRREREARRQQEREQRRREQEEKRRL-EELERRRKEEEERRRAE---EEK 458 Query: 86 RELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQ----LLHRER 125 R + + QE ++R+ E E R L E Q+QL Q LLH R Sbjct: 459 RRVEREQEYIRRQLEEEQRHL----EVLQQQLLQEQAMLLHDHR 498 Score = 41.2 bits (95), Expect = 0.008 Identities = 74/296 (25%), Positives = 118/296 (39%), Gaps = 101/296 (34%) Query: 523 RDLDRLQRESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRRQMLA---------- 572 RD RLQ+E++ L+RQ +LQ+ Q EE +RQ+LA Sbjct: 354 RDFLRLQQENKERSEALRRQQLLQEQ----------QLREQEEYKRQLLAERQKRIEQQK 403 Query: 573 -----------------LERELDQRRRECQELGAQAAPARRRGEEAETQLQAALLKNAWL 615 ++E +QRRRE +E +RR EE E + + Sbjct: 404 EQRRRLEEQQRREREARRQQEREQRRREQEE--------KRRLEELERRRK--------- 446 Query: 616 AEENGRLQAKTDWVRKVEAENSEVRGHLGRACQERDASGLIAEQLLQQAARGQDRQQQLQ 675 EE R +A+ + R+VE E +R L +E+ ++ +QLLQ+ Q L Sbjct: 447 -EEEERRRAEEE-KRRVEREQEYIRRQLE---EEQRHLEVLQQQLLQE-------QAMLL 494 Query: 676 RDPQKALCDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQVKGSRRPKFHARPEDYAVS 735 D ++ HP + SQ P + +P FHA PE A Sbjct: 495 HDHRRP----HP--------------------QHSQQPPPPQQERSKPSFHA-PEPKAHY 529 Query: 736 QP---NRDIQEKREASLEESPVALGESASVPQVSETVPASQPLSKKTSSQSNSSSE 788 +P R+++++ + SP A +S +V E P+ ++ S SN +SE Sbjct: 530 EPADRAREVEDRFRKTNHSSPEA--QSKQTGRVLE-----PPVPSRSESFSNGNSE 578 >gi|56549694 enabled homolog isoform a [Homo sapiens] Length = 591 Score = 62.0 bits (149), Expect = 5e-09 Identities = 57/168 (33%), Positives = 83/168 (49%), Gaps = 9/168 (5%) Query: 19 SSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRS 78 + P+ LE QRR+L++ + + E ER R ER R RER RE ERER + +RL Sbjct: 133 NGPSQEELEIQRRQLQEQQRQKELERE--RLERERM-ERERLERERLERERLE-RERLEQ 188 Query: 79 KWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVV---RQAREL 135 + + +R R+ R+ QE ++R+ E ++ L +E R+ Q+ RER + RQ RE Sbjct: 189 E-QLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERER 247 Query: 136 QRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAA 183 Q QL E + R +S + A L VL G QAA Sbjct: 248 QEQLEREQL-EWERERRISSAAAPASVETPLNSVLGDSSASEPGLQAA 294 Score = 50.8 bits (120), Expect = 1e-05 Identities = 76/278 (27%), Positives = 111/278 (39%), Gaps = 49/278 (17%) Query: 62 REEAERERRQLADRLRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQ-QL 120 +EE E +RRQL ++ R K E +R R R+ E + ERE R+ L + EQ QL+ + Sbjct: 137 QEELEIQRRQLQEQQRQK-ELERERLERERMERERLERERLERERLERERLEQEQLERER 195 Query: 121 LHRERDGVVRQARELQRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGE 180 RER + + L+RQ E L + R E Q R RL+ + + + + E Sbjct: 196 QERERQERLERQERLERQ--ERLERQERLDR----ERQERQERERLERLERERQERERQE 249 Query: 181 QAARIRYLQAALEVERQLFLKYILAHFRGHPALSGSPDPQAVHSLEEPLPQTSSGSCHAP 240 Q R + LE ER+ + A PA S+E PL + G A Sbjct: 250 QLEREQ-----LEWERERRISSAAA-----PA-----------SVETPL-NSVLGDSSAS 287 Query: 241 KPACQLGSLDSLSAEVGVRSRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTR 300 +P Q S + + G+V + P L PA ++ Sbjct: 288 EPGLQAASQPAETPS------QQGIVLGPLAPPPPPPLPP--------GPA-----QASV 328 Query: 301 SLPKASKSEERPSSPDTSTPGSRRLSPPPSPLPPPPPP 338 +LP P P T P P P+ +PPPPPP Sbjct: 329 ALPPPPGPPPPPPLPSTGPPPPPPPPPLPNQVPPPPPP 366 Score = 33.5 bits (75), Expect = 1.7 Identities = 31/118 (26%), Positives = 41/118 (34%) Query: 249 LDSLSAEVGVRSRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTRSLPKASKS 308 L+ L E R R L + +S+ A+ P S DS+ S P + Sbjct: 235 LERLERERQERERQEQLEREQLEWERERRISSAAAPASVETPLNSVLGDSSASEPGLQAA 294 Query: 309 EERPSSPDTSTPGSRRLSPPPSPLPPPPPPSAHRKLSNPRGGEGSESQPCEVLTPSPP 366 + +P L+PPP P PP P A L P G P P PP Sbjct: 295 SQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPGPPPPPPLPSTGPPPPPP 352 >gi|39930375 enabled homolog isoform b [Homo sapiens] Length = 570 Score = 62.0 bits (149), Expect = 5e-09 Identities = 57/168 (33%), Positives = 83/168 (49%), Gaps = 9/168 (5%) Query: 19 SSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRS 78 + P+ LE QRR+L++ + + E ER R ER R RER RE ERER + +RL Sbjct: 133 NGPSQEELEIQRRQLQEQQRQKELERE--RLERERM-ERERLERERLERERLE-RERLEQ 188 Query: 79 KWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVV---RQAREL 135 + + +R R+ R+ QE ++R+ E ++ L +E R+ Q+ RER + RQ RE Sbjct: 189 E-QLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERER 247 Query: 136 QRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAA 183 Q QL E + R +S + A L VL G QAA Sbjct: 248 QEQLEREQL-EWERERRISSAAAPASVETPLNSVLGDSSASEPGLQAA 294 Score = 50.8 bits (120), Expect = 1e-05 Identities = 76/278 (27%), Positives = 111/278 (39%), Gaps = 49/278 (17%) Query: 62 REEAERERRQLADRLRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQ-QL 120 +EE E +RRQL ++ R K E +R R R+ E + ERE R+ L + EQ QL+ + Sbjct: 137 QEELEIQRRQLQEQQRQK-ELERERLERERMERERLERERLERERLERERLEQEQLERER 195 Query: 121 LHRERDGVVRQARELQRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGE 180 RER + + L+RQ E L + R E Q R RL+ + + + + E Sbjct: 196 QERERQERLERQERLERQ--ERLERQERLDR----ERQERQERERLERLERERQERERQE 249 Query: 181 QAARIRYLQAALEVERQLFLKYILAHFRGHPALSGSPDPQAVHSLEEPLPQTSSGSCHAP 240 Q R + LE ER+ + A PA S+E PL + G A Sbjct: 250 QLEREQ-----LEWERERRISSAAA-----PA-----------SVETPL-NSVLGDSSAS 287 Query: 241 KPACQLGSLDSLSAEVGVRSRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTR 300 +P Q S + + G+V + P L PA ++ Sbjct: 288 EPGLQAASQPAETPS------QQGIVLGPLAPPPPPPLPP--------GPA-----QASV 328 Query: 301 SLPKASKSEERPSSPDTSTPGSRRLSPPPSPLPPPPPP 338 +LP P P T P P P+ +PPPPPP Sbjct: 329 ALPPPPGPPPPPPLPSTGPPPPPPPPPLPNQVPPPPPP 366 Score = 33.5 bits (75), Expect = 1.7 Identities = 31/118 (26%), Positives = 41/118 (34%) Query: 249 LDSLSAEVGVRSRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTRSLPKASKS 308 L+ L E R R L + +S+ A+ P S DS+ S P + Sbjct: 235 LERLERERQERERQEQLEREQLEWERERRISSAAAPASVETPLNSVLGDSSASEPGLQAA 294 Query: 309 EERPSSPDTSTPGSRRLSPPPSPLPPPPPPSAHRKLSNPRGGEGSESQPCEVLTPSPP 366 + +P L+PPP P PP P A L P G P P PP Sbjct: 295 SQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPGPPPPPPLPSTGPPPPPP 352 >gi|157502225 Janus kinase and microtubule interacting protein 3 [Homo sapiens] Length = 844 Score = 61.6 bits (148), Expect = 6e-09 Identities = 51/186 (27%), Positives = 89/186 (47%), Gaps = 6/186 (3%) Query: 7 SPLGASPKKPGCSSPAAAVL----ENQRRELEKLRAELEAERAGWRAERRRFAARERQLR 62 S G S + G + A A L E+ R +L ++ EL+ E++ R RQ+R Sbjct: 2 SKRGMSSRAKGDKAEALAALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQVR 61 Query: 63 EEAERERRQLADRLRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLH 122 E + + L L++K ++ +EL+ ++E + R+ EAE+ ++++ K+ E ++LQ LL Sbjct: 62 EHEQHKTAVLLTELKTKLHEEKMKELQAVRETLLRQHEAELLRVIKIKDNENQRLQALLS 121 Query: 123 RERDGVVRQARELQRQLAEELVNRGHCSR--PGASEVSAAQCRCRLQEVLAQLRWQTDGE 180 RDG + + + A+E +G E+S + R E L Q D Sbjct: 122 ALRDGGPEKVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADKI 181 Query: 181 QAARIR 186 +AA IR Sbjct: 182 KAAEIR 187 Score = 31.2 bits (69), Expect = 8.6 Identities = 27/90 (30%), Positives = 45/90 (50%), Gaps = 7/90 (7%) Query: 32 ELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSRE-LRQ 90 ELE + + + AG + +L+ E+ +RQ+ LR + +AQ RE + Sbjct: 742 ELEAMLYDALQQEAGAKVAELLSEEEREKLKVAVEQWKRQVMSELRER-DAQILRERMEL 800 Query: 91 LQEEMQREREAEIRQLLRWKEAEQRQLQQL 120 LQ QR +E E R EA++RQ+++L Sbjct: 801 LQLAQQRIKELEER-----IEAQKRQIKEL 825 >gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sapiens] Length = 1293 Score = 60.8 bits (146), Expect = 1e-08 Identities = 73/263 (27%), Positives = 121/263 (46%), Gaps = 43/263 (16%) Query: 4 DSPSPLGASPKKPGCSSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLRE 63 D+ +P A + AA LE +RRE E +RA+ E E + E RR + ++ Sbjct: 709 DTTTPGPALEQLQQLEKAKAAKLEQERREAE-MRAKREEEERKRQEELRRQQEEILRRQQ 767 Query: 64 EAERERRQLADRLRSKWE----AQRSREL---RQLQEEMQREREAEIRQL--LRWKEAEQ 114 E ER+RR+ + R K E QR +E+ RQ +EE ++++E +R+L R +E E+ Sbjct: 768 EEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEER 827 Query: 115 RQLQQLLHRERDGVVRQAR---ELQRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLA 171 R+ ++LL ++ + + AR E QR+L E R R++E A Sbjct: 828 RKQEELLRKQEEEAAKWAREEEEAQRRLEEN--------------------RLRMEEEAA 867 Query: 172 QLRWQTDGEQAARIRYLQAALEVERQLFLKYILAHFRGHPALSGSPDPQAVHSLEE-PLP 230 +LR + + + + LEV+RQ L + + AL Q L + LP Sbjct: 868 RLRHEEEERK-------RKELEVQRQKEL--MRQRQQQQEALRRLQQQQQQQQLAQMKLP 918 Query: 231 QTSSGSCHAPKPACQLGSLDSLS 253 +S+ + ACQ + SL+ Sbjct: 919 SSSTWGQQSNTTACQSQATLSLA 941 Score = 56.6 bits (135), Expect = 2e-07 Identities = 46/195 (23%), Positives = 91/195 (46%), Gaps = 43/195 (22%) Query: 27 ENQRRELEKLRAELEAERAGWRAE----RRRFAARERQLREEAERERRQLADRLRSKWEA 82 E +RR+ E+L + E E A W E +RR ++ EEA R R + +R R + E Sbjct: 824 EEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEV 883 Query: 83 QRSREL-----------RQLQEEMQREREAEIR-------------------------QL 106 QR +EL R+LQ++ Q+++ A+++ ++ Sbjct: 884 QRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEI 943 Query: 107 LRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEELVNRGHCSRPGASEVSAAQCRCRL 166 + +E +RQL++ R++ +++ ++ Q+Q ++L G+ S+P + S + + Sbjct: 944 QKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQ--- 1000 Query: 167 QEVLAQLRWQTDGEQ 181 QE Q++ Q +Q Sbjct: 1001 QEEARQMQKQQQQQQ 1015 Score = 40.8 bits (94), Expect = 0.011 Identities = 41/148 (27%), Positives = 67/148 (45%), Gaps = 18/148 (12%) Query: 523 RDLDRLQRESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRRQMLALERELDQRRR 582 R+ + L R Q E LR QR+ E + EE R+Q R L++RRR Sbjct: 774 REEEELARRKQEEALRRQRE-----------QEIALRRQREEEERQQQEEALRRLEERRR 822 Query: 583 ECQELGAQAAPARRRGEEA------ETQLQAALLKNAW-LAEENGRLQAKTDWVRKVEAE 635 E +E Q R++ EEA E + Q L +N + EE RL+ + + ++ E E Sbjct: 823 EEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELE 882 Query: 636 NSEVRGHLGRACQERDASGLIAEQLLQQ 663 + + + Q+++A + +Q QQ Sbjct: 883 VQRQKELMRQRQQQQEALRRLQQQQQQQ 910 Score = 33.9 bits (76), Expect = 1.3 Identities = 48/212 (22%), Positives = 92/212 (43%), Gaps = 32/212 (15%) Query: 564 EEVRRQ---MLALERELDQRRRECQELGA-------------QAAPARRRGEEAETQLQA 607 EE+RRQ +L ++E +++RRE +EL + A R+R EE Q + Sbjct: 753 EELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEE 812 Query: 608 ALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLGRACQERDASGLIAEQLL---QQA 664 AL + E + + + +RK E E ++ A +E +A + E L ++A Sbjct: 813 ALRRLEERRREEEERRKQEELLRKQEEEAAK------WAREEEEAQRRLEENRLRMEEEA 866 Query: 665 AR-----GQDRQQQLQRDPQKALCDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQVKG 719 AR + ++++L+ QK L + ++ +AL+ +Q ++P S G Sbjct: 867 ARLRHEEEERKRKELEVQRQKEL--MRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWG 924 Query: 720 SRRPKFHARPEDYAVSQPNRDIQEKREASLEE 751 + + + + ++E+RE L E Sbjct: 925 QQSNTTACQSQATLSLAEIQKLEEERERQLRE 956 Score = 33.5 bits (75), Expect = 1.7 Identities = 35/141 (24%), Positives = 56/141 (39%), Gaps = 45/141 (31%) Query: 1 MAKDSPSPLGASPKKPGCSSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQ 60 M S S G C S A L E++KL E RERQ Sbjct: 915 MKLPSSSTWGQQSNTTACQSQATLSLA----EIQKLEEE-----------------RERQ 953 Query: 61 LREEAERERRQLADRLRSKWEAQR---------------SRELRQLQEEMQREREAEIRQ 105 LREE R++R+L L+ + + Q+ ++ L ++Q+E R+ + Sbjct: 954 LREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQ----- 1008 Query: 106 LLRWKEAEQRQLQQLLHRERD 126 K+ +Q+Q Q +R R+ Sbjct: 1009 ----KQQQQQQQHQQPNRARN 1025 Score = 33.1 bits (74), Expect = 2.3 Identities = 45/237 (18%), Positives = 94/237 (39%), Gaps = 21/237 (8%) Query: 395 QAENKQLRRAGCPYQADEKVKR----LKVKRAELTGLARRLADRARKLQETNLRAVSAPI 450 Q + + LRR + +E+ ++ L+ + E AR + R+L+E LR Sbjct: 808 QQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAA 867 Query: 451 PGESCAGLELCQVFARQRARDLSEQASAPLAKDKQIEELRQECHLLQARVASGPCSDLHT 510 + QR ++L Q +++++ +Q+ L Q ++ S + Sbjct: 868 RLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQS 927 Query: 511 GRGGPCTQ-WLNVRDLDRL-----------QRESQREVLR-LQRQLMLQQGNGGAWPEAG 557 +Q L++ ++ +L QR QRE+++ LQ+Q QQ W Sbjct: 928 NTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVS 987 Query: 558 GQSATCEEVRRQMLALERELDQRRRECQELGAQAAPARRRGEEAETQLQAALLKNAW 614 S T + +L +++E ++ ++ Q+ Q R + L ++ + W Sbjct: 988 KPSGT----TKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHSNLHTSIGNSVW 1040 Score = 32.7 bits (73), Expect = 3.0 Identities = 52/245 (21%), Positives = 95/245 (38%), Gaps = 48/245 (19%) Query: 481 AKDKQIEELRQECHLLQARVASGPCSDLHTGRG---------GPCTQWLNVRDLDRLQRE 531 A+ Q ++ +Q+ H R + S+LHT G GP QW + DL Sbjct: 1004 ARQMQKQQQQQQQHQQPNRARNNTHSNLHTSIGNSVWGSINTGPPNQWAS--DL------ 1055 Query: 532 SQREVLRLQRQLMLQQGNGGAWPEA----GGQSATCEEVRRQMLALERELDQRRR---EC 584 V + + N G W +A G +++T + L+ + R+ E Sbjct: 1056 ----VSSIWSNADTKNSNMGFWDDAVKEVGPRNSTNKNKNNASLSKSVGVSNRQNKKVEE 1111 Query: 585 QELGAQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAE---NSEVRG 641 +E + + ++ TQ +L +A N + ++++VE+ + +R Sbjct: 1112 EEKLLKLFQGVNKAQDGFTQWCEQML-HALNTANNLDVPTFVSFLKEVESPYEVHDYIRA 1170 Query: 642 HLGRACQERDASGLIAEQLLQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQALQCRPGH 701 +LG + ++ + E+ +Q A Q +QQQL + Q Q P Sbjct: 1171 YLGDTSEAKEFAKQFLERRAKQKANQQRQQQQLPQQQQ----------------QQPPQQ 1214 Query: 702 PPEQP 706 PP+QP Sbjct: 1215 PPQQP 1219 >gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sapiens] Length = 1320 Score = 60.8 bits (146), Expect = 1e-08 Identities = 73/263 (27%), Positives = 121/263 (46%), Gaps = 43/263 (16%) Query: 4 DSPSPLGASPKKPGCSSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLRE 63 D+ +P A + AA LE +RRE E +RA+ E E + E RR + ++ Sbjct: 736 DTTTPGPALEQLQQLEKAKAAKLEQERREAE-MRAKREEEERKRQEELRRQQEEILRRQQ 794 Query: 64 EAERERRQLADRLRSKWE----AQRSREL---RQLQEEMQREREAEIRQL--LRWKEAEQ 114 E ER+RR+ + R K E QR +E+ RQ +EE ++++E +R+L R +E E+ Sbjct: 795 EEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEER 854 Query: 115 RQLQQLLHRERDGVVRQAR---ELQRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLA 171 R+ ++LL ++ + + AR E QR+L E R R++E A Sbjct: 855 RKQEELLRKQEEEAAKWAREEEEAQRRLEEN--------------------RLRMEEEAA 894 Query: 172 QLRWQTDGEQAARIRYLQAALEVERQLFLKYILAHFRGHPALSGSPDPQAVHSLEE-PLP 230 +LR + + + + LEV+RQ L + + AL Q L + LP Sbjct: 895 RLRHEEEERK-------RKELEVQRQKEL--MRQRQQQQEALRRLQQQQQQQQLAQMKLP 945 Query: 231 QTSSGSCHAPKPACQLGSLDSLS 253 +S+ + ACQ + SL+ Sbjct: 946 SSSTWGQQSNTTACQSQATLSLA 968 Score = 56.6 bits (135), Expect = 2e-07 Identities = 46/195 (23%), Positives = 91/195 (46%), Gaps = 43/195 (22%) Query: 27 ENQRRELEKLRAELEAERAGWRAE----RRRFAARERQLREEAERERRQLADRLRSKWEA 82 E +RR+ E+L + E E A W E +RR ++ EEA R R + +R R + E Sbjct: 851 EEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEV 910 Query: 83 QRSREL-----------RQLQEEMQREREAEIR-------------------------QL 106 QR +EL R+LQ++ Q+++ A+++ ++ Sbjct: 911 QRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEI 970 Query: 107 LRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEELVNRGHCSRPGASEVSAAQCRCRL 166 + +E +RQL++ R++ +++ ++ Q+Q ++L G+ S+P + S + + Sbjct: 971 QKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQ--- 1027 Query: 167 QEVLAQLRWQTDGEQ 181 QE Q++ Q +Q Sbjct: 1028 QEEARQMQKQQQQQQ 1042 Score = 40.8 bits (94), Expect = 0.011 Identities = 41/148 (27%), Positives = 67/148 (45%), Gaps = 18/148 (12%) Query: 523 RDLDRLQRESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRRQMLALERELDQRRR 582 R+ + L R Q E LR QR+ E + EE R+Q R L++RRR Sbjct: 801 REEEELARRKQEEALRRQRE-----------QEIALRRQREEEERQQQEEALRRLEERRR 849 Query: 583 ECQELGAQAAPARRRGEEA------ETQLQAALLKNAW-LAEENGRLQAKTDWVRKVEAE 635 E +E Q R++ EEA E + Q L +N + EE RL+ + + ++ E E Sbjct: 850 EEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELE 909 Query: 636 NSEVRGHLGRACQERDASGLIAEQLLQQ 663 + + + Q+++A + +Q QQ Sbjct: 910 VQRQKELMRQRQQQQEALRRLQQQQQQQ 937 Score = 33.9 bits (76), Expect = 1.3 Identities = 48/212 (22%), Positives = 92/212 (43%), Gaps = 32/212 (15%) Query: 564 EEVRRQ---MLALERELDQRRRECQELGA-------------QAAPARRRGEEAETQLQA 607 EE+RRQ +L ++E +++RRE +EL + A R+R EE Q + Sbjct: 780 EELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEE 839 Query: 608 ALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLGRACQERDASGLIAEQLL---QQA 664 AL + E + + + +RK E E ++ A +E +A + E L ++A Sbjct: 840 ALRRLEERRREEEERRKQEELLRKQEEEAAK------WAREEEEAQRRLEENRLRMEEEA 893 Query: 665 AR-----GQDRQQQLQRDPQKALCDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQVKG 719 AR + ++++L+ QK L + ++ +AL+ +Q ++P S G Sbjct: 894 ARLRHEEEERKRKELEVQRQKEL--MRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWG 951 Query: 720 SRRPKFHARPEDYAVSQPNRDIQEKREASLEE 751 + + + + ++E+RE L E Sbjct: 952 QQSNTTACQSQATLSLAEIQKLEEERERQLRE 983 Score = 33.5 bits (75), Expect = 1.7 Identities = 35/141 (24%), Positives = 56/141 (39%), Gaps = 45/141 (31%) Query: 1 MAKDSPSPLGASPKKPGCSSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQ 60 M S S G C S A L E++KL E RERQ Sbjct: 942 MKLPSSSTWGQQSNTTACQSQATLSLA----EIQKLEEE-----------------RERQ 980 Query: 61 LREEAERERRQLADRLRSKWEAQR---------------SRELRQLQEEMQREREAEIRQ 105 LREE R++R+L L+ + + Q+ ++ L ++Q+E R+ + Sbjct: 981 LREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQ----- 1035 Query: 106 LLRWKEAEQRQLQQLLHRERD 126 K+ +Q+Q Q +R R+ Sbjct: 1036 ----KQQQQQQQHQQPNRARN 1052 Score = 33.1 bits (74), Expect = 2.3 Identities = 45/237 (18%), Positives = 94/237 (39%), Gaps = 21/237 (8%) Query: 395 QAENKQLRRAGCPYQADEKVKR----LKVKRAELTGLARRLADRARKLQETNLRAVSAPI 450 Q + + LRR + +E+ ++ L+ + E AR + R+L+E LR Sbjct: 835 QQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAA 894 Query: 451 PGESCAGLELCQVFARQRARDLSEQASAPLAKDKQIEELRQECHLLQARVASGPCSDLHT 510 + QR ++L Q +++++ +Q+ L Q ++ S + Sbjct: 895 RLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQS 954 Query: 511 GRGGPCTQ-WLNVRDLDRL-----------QRESQREVLR-LQRQLMLQQGNGGAWPEAG 557 +Q L++ ++ +L QR QRE+++ LQ+Q QQ W Sbjct: 955 NTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVS 1014 Query: 558 GQSATCEEVRRQMLALERELDQRRRECQELGAQAAPARRRGEEAETQLQAALLKNAW 614 S T + +L +++E ++ ++ Q+ Q R + L ++ + W Sbjct: 1015 KPSGT----TKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHSNLHTSIGNSVW 1067 Score = 32.7 bits (73), Expect = 3.0 Identities = 52/245 (21%), Positives = 95/245 (38%), Gaps = 48/245 (19%) Query: 481 AKDKQIEELRQECHLLQARVASGPCSDLHTGRG---------GPCTQWLNVRDLDRLQRE 531 A+ Q ++ +Q+ H R + S+LHT G GP QW + DL Sbjct: 1031 ARQMQKQQQQQQQHQQPNRARNNTHSNLHTSIGNSVWGSINTGPPNQWAS--DL------ 1082 Query: 532 SQREVLRLQRQLMLQQGNGGAWPEA----GGQSATCEEVRRQMLALERELDQRRR---EC 584 V + + N G W +A G +++T + L+ + R+ E Sbjct: 1083 ----VSSIWSNADTKNSNMGFWDDAVKEVGPRNSTNKNKNNASLSKSVGVSNRQNKKVEE 1138 Query: 585 QELGAQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAE---NSEVRG 641 +E + + ++ TQ +L +A N + ++++VE+ + +R Sbjct: 1139 EEKLLKLFQGVNKAQDGFTQWCEQML-HALNTANNLDVPTFVSFLKEVESPYEVHDYIRA 1197 Query: 642 HLGRACQERDASGLIAEQLLQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQALQCRPGH 701 +LG + ++ + E+ +Q A Q +QQQL + Q Q P Sbjct: 1198 YLGDTSEAKEFAKQFLERRAKQKANQQRQQQQLPQQQQ----------------QQPPQQ 1241 Query: 702 PPEQP 706 PP+QP Sbjct: 1242 PPQQP 1246 >gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sapiens] Length = 1299 Score = 60.8 bits (146), Expect = 1e-08 Identities = 73/263 (27%), Positives = 121/263 (46%), Gaps = 43/263 (16%) Query: 4 DSPSPLGASPKKPGCSSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLRE 63 D+ +P A + AA LE +RRE E +RA+ E E + E RR + ++ Sbjct: 715 DTTTPGPALEQLQQLEKAKAAKLEQERREAE-MRAKREEEERKRQEELRRQQEEILRRQQ 773 Query: 64 EAERERRQLADRLRSKWE----AQRSREL---RQLQEEMQREREAEIRQL--LRWKEAEQ 114 E ER+RR+ + R K E QR +E+ RQ +EE ++++E +R+L R +E E+ Sbjct: 774 EEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEER 833 Query: 115 RQLQQLLHRERDGVVRQAR---ELQRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLA 171 R+ ++LL ++ + + AR E QR+L E R R++E A Sbjct: 834 RKQEELLRKQEEEAAKWAREEEEAQRRLEEN--------------------RLRMEEEAA 873 Query: 172 QLRWQTDGEQAARIRYLQAALEVERQLFLKYILAHFRGHPALSGSPDPQAVHSLEE-PLP 230 +LR + + + + LEV+RQ L + + AL Q L + LP Sbjct: 874 RLRHEEEERK-------RKELEVQRQKEL--MRQRQQQQEALRRLQQQQQQQQLAQMKLP 924 Query: 231 QTSSGSCHAPKPACQLGSLDSLS 253 +S+ + ACQ + SL+ Sbjct: 925 SSSTWGQQSNTTACQSQATLSLA 947 Score = 56.6 bits (135), Expect = 2e-07 Identities = 46/195 (23%), Positives = 91/195 (46%), Gaps = 43/195 (22%) Query: 27 ENQRRELEKLRAELEAERAGWRAE----RRRFAARERQLREEAERERRQLADRLRSKWEA 82 E +RR+ E+L + E E A W E +RR ++ EEA R R + +R R + E Sbjct: 830 EEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEV 889 Query: 83 QRSREL-----------RQLQEEMQREREAEIR-------------------------QL 106 QR +EL R+LQ++ Q+++ A+++ ++ Sbjct: 890 QRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEI 949 Query: 107 LRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEELVNRGHCSRPGASEVSAAQCRCRL 166 + +E +RQL++ R++ +++ ++ Q+Q ++L G+ S+P + S + + Sbjct: 950 QKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQ--- 1006 Query: 167 QEVLAQLRWQTDGEQ 181 QE Q++ Q +Q Sbjct: 1007 QEEARQMQKQQQQQQ 1021 Score = 40.8 bits (94), Expect = 0.011 Identities = 41/148 (27%), Positives = 67/148 (45%), Gaps = 18/148 (12%) Query: 523 RDLDRLQRESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRRQMLALERELDQRRR 582 R+ + L R Q E LR QR+ E + EE R+Q R L++RRR Sbjct: 780 REEEELARRKQEEALRRQRE-----------QEIALRRQREEEERQQQEEALRRLEERRR 828 Query: 583 ECQELGAQAAPARRRGEEA------ETQLQAALLKNAW-LAEENGRLQAKTDWVRKVEAE 635 E +E Q R++ EEA E + Q L +N + EE RL+ + + ++ E E Sbjct: 829 EEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELE 888 Query: 636 NSEVRGHLGRACQERDASGLIAEQLLQQ 663 + + + Q+++A + +Q QQ Sbjct: 889 VQRQKELMRQRQQQQEALRRLQQQQQQQ 916 Score = 33.9 bits (76), Expect = 1.3 Identities = 48/212 (22%), Positives = 92/212 (43%), Gaps = 32/212 (15%) Query: 564 EEVRRQ---MLALERELDQRRRECQELGA-------------QAAPARRRGEEAETQLQA 607 EE+RRQ +L ++E +++RRE +EL + A R+R EE Q + Sbjct: 759 EELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEE 818 Query: 608 ALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLGRACQERDASGLIAEQLL---QQA 664 AL + E + + + +RK E E ++ A +E +A + E L ++A Sbjct: 819 ALRRLEERRREEEERRKQEELLRKQEEEAAK------WAREEEEAQRRLEENRLRMEEEA 872 Query: 665 AR-----GQDRQQQLQRDPQKALCDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQVKG 719 AR + ++++L+ QK L + ++ +AL+ +Q ++P S G Sbjct: 873 ARLRHEEEERKRKELEVQRQKEL--MRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWG 930 Query: 720 SRRPKFHARPEDYAVSQPNRDIQEKREASLEE 751 + + + + ++E+RE L E Sbjct: 931 QQSNTTACQSQATLSLAEIQKLEEERERQLRE 962 Score = 33.5 bits (75), Expect = 1.7 Identities = 35/141 (24%), Positives = 56/141 (39%), Gaps = 45/141 (31%) Query: 1 MAKDSPSPLGASPKKPGCSSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQ 60 M S S G C S A L E++KL E RERQ Sbjct: 921 MKLPSSSTWGQQSNTTACQSQATLSLA----EIQKLEEE-----------------RERQ 959 Query: 61 LREEAERERRQLADRLRSKWEAQR---------------SRELRQLQEEMQREREAEIRQ 105 LREE R++R+L L+ + + Q+ ++ L ++Q+E R+ + Sbjct: 960 LREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQ----- 1014 Query: 106 LLRWKEAEQRQLQQLLHRERD 126 K+ +Q+Q Q +R R+ Sbjct: 1015 ----KQQQQQQQHQQPNRARN 1031 Score = 33.1 bits (74), Expect = 2.3 Identities = 45/237 (18%), Positives = 94/237 (39%), Gaps = 21/237 (8%) Query: 395 QAENKQLRRAGCPYQADEKVKR----LKVKRAELTGLARRLADRARKLQETNLRAVSAPI 450 Q + + LRR + +E+ ++ L+ + E AR + R+L+E LR Sbjct: 814 QQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAA 873 Query: 451 PGESCAGLELCQVFARQRARDLSEQASAPLAKDKQIEELRQECHLLQARVASGPCSDLHT 510 + QR ++L Q +++++ +Q+ L Q ++ S + Sbjct: 874 RLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQS 933 Query: 511 GRGGPCTQ-WLNVRDLDRL-----------QRESQREVLR-LQRQLMLQQGNGGAWPEAG 557 +Q L++ ++ +L QR QRE+++ LQ+Q QQ W Sbjct: 934 NTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVS 993 Query: 558 GQSATCEEVRRQMLALERELDQRRRECQELGAQAAPARRRGEEAETQLQAALLKNAW 614 S T + +L +++E ++ ++ Q+ Q R + L ++ + W Sbjct: 994 KPSGT----TKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHSNLHTSIGNSVW 1046 Score = 32.7 bits (73), Expect = 3.0 Identities = 52/245 (21%), Positives = 95/245 (38%), Gaps = 48/245 (19%) Query: 481 AKDKQIEELRQECHLLQARVASGPCSDLHTGRG---------GPCTQWLNVRDLDRLQRE 531 A+ Q ++ +Q+ H R + S+LHT G GP QW + DL Sbjct: 1010 ARQMQKQQQQQQQHQQPNRARNNTHSNLHTSIGNSVWGSINTGPPNQWAS--DL------ 1061 Query: 532 SQREVLRLQRQLMLQQGNGGAWPEA----GGQSATCEEVRRQMLALERELDQRRR---EC 584 V + + N G W +A G +++T + L+ + R+ E Sbjct: 1062 ----VSSIWSNADTKNSNMGFWDDAVKEVGPRNSTNKNKNNASLSKSVGVSNRQNKKVEE 1117 Query: 585 QELGAQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAE---NSEVRG 641 +E + + ++ TQ +L +A N + ++++VE+ + +R Sbjct: 1118 EEKLLKLFQGVNKAQDGFTQWCEQML-HALNTANNLDVPTFVSFLKEVESPYEVHDYIRA 1176 Query: 642 HLGRACQERDASGLIAEQLLQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQALQCRPGH 701 +LG + ++ + E+ +Q A Q +QQQL + Q Q P Sbjct: 1177 YLGDTSEAKEFAKQFLERRAKQKANQQRQQQQLPQQQQ----------------QQPPQQ 1220 Query: 702 PPEQP 706 PP+QP Sbjct: 1221 PPQQP 1225 >gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapiens] Length = 1299 Score = 60.8 bits (146), Expect = 1e-08 Identities = 73/263 (27%), Positives = 121/263 (46%), Gaps = 43/263 (16%) Query: 4 DSPSPLGASPKKPGCSSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLRE 63 D+ +P A + AA LE +RRE E +RA+ E E + E RR + ++ Sbjct: 715 DTTTPGPALEQLQQLEKAKAAKLEQERREAE-MRAKREEEERKRQEELRRQQEEILRRQQ 773 Query: 64 EAERERRQLADRLRSKWE----AQRSREL---RQLQEEMQREREAEIRQL--LRWKEAEQ 114 E ER+RR+ + R K E QR +E+ RQ +EE ++++E +R+L R +E E+ Sbjct: 774 EEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEER 833 Query: 115 RQLQQLLHRERDGVVRQAR---ELQRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLA 171 R+ ++LL ++ + + AR E QR+L E R R++E A Sbjct: 834 RKQEELLRKQEEEAAKWAREEEEAQRRLEEN--------------------RLRMEEEAA 873 Query: 172 QLRWQTDGEQAARIRYLQAALEVERQLFLKYILAHFRGHPALSGSPDPQAVHSLEE-PLP 230 +LR + + + + LEV+RQ L + + AL Q L + LP Sbjct: 874 RLRHEEEERK-------RKELEVQRQKEL--MRQRQQQQEALRRLQQQQQQQQLAQMKLP 924 Query: 231 QTSSGSCHAPKPACQLGSLDSLS 253 +S+ + ACQ + SL+ Sbjct: 925 SSSTWGQQSNTTACQSQATLSLA 947 Score = 56.6 bits (135), Expect = 2e-07 Identities = 46/195 (23%), Positives = 91/195 (46%), Gaps = 43/195 (22%) Query: 27 ENQRRELEKLRAELEAERAGWRAE----RRRFAARERQLREEAERERRQLADRLRSKWEA 82 E +RR+ E+L + E E A W E +RR ++ EEA R R + +R R + E Sbjct: 830 EEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEV 889 Query: 83 QRSREL-----------RQLQEEMQREREAEIR-------------------------QL 106 QR +EL R+LQ++ Q+++ A+++ ++ Sbjct: 890 QRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEI 949 Query: 107 LRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEELVNRGHCSRPGASEVSAAQCRCRL 166 + +E +RQL++ R++ +++ ++ Q+Q ++L G+ S+P + S + + Sbjct: 950 QKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQ--- 1006 Query: 167 QEVLAQLRWQTDGEQ 181 QE Q++ Q +Q Sbjct: 1007 QEEARQMQKQQQQQQ 1021 Score = 40.8 bits (94), Expect = 0.011 Identities = 41/148 (27%), Positives = 67/148 (45%), Gaps = 18/148 (12%) Query: 523 RDLDRLQRESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRRQMLALERELDQRRR 582 R+ + L R Q E LR QR+ E + EE R+Q R L++RRR Sbjct: 780 REEEELARRKQEEALRRQRE-----------QEIALRRQREEEERQQQEEALRRLEERRR 828 Query: 583 ECQELGAQAAPARRRGEEA------ETQLQAALLKNAW-LAEENGRLQAKTDWVRKVEAE 635 E +E Q R++ EEA E + Q L +N + EE RL+ + + ++ E E Sbjct: 829 EEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELE 888 Query: 636 NSEVRGHLGRACQERDASGLIAEQLLQQ 663 + + + Q+++A + +Q QQ Sbjct: 889 VQRQKELMRQRQQQQEALRRLQQQQQQQ 916 Score = 33.9 bits (76), Expect = 1.3 Identities = 48/212 (22%), Positives = 92/212 (43%), Gaps = 32/212 (15%) Query: 564 EEVRRQ---MLALERELDQRRRECQELGA-------------QAAPARRRGEEAETQLQA 607 EE+RRQ +L ++E +++RRE +EL + A R+R EE Q + Sbjct: 759 EELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEE 818 Query: 608 ALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLGRACQERDASGLIAEQLL---QQA 664 AL + E + + + +RK E E ++ A +E +A + E L ++A Sbjct: 819 ALRRLEERRREEEERRKQEELLRKQEEEAAK------WAREEEEAQRRLEENRLRMEEEA 872 Query: 665 AR-----GQDRQQQLQRDPQKALCDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQVKG 719 AR + ++++L+ QK L + ++ +AL+ +Q ++P S G Sbjct: 873 ARLRHEEEERKRKELEVQRQKEL--MRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWG 930 Query: 720 SRRPKFHARPEDYAVSQPNRDIQEKREASLEE 751 + + + + ++E+RE L E Sbjct: 931 QQSNTTACQSQATLSLAEIQKLEEERERQLRE 962 Score = 33.5 bits (75), Expect = 1.7 Identities = 35/141 (24%), Positives = 56/141 (39%), Gaps = 45/141 (31%) Query: 1 MAKDSPSPLGASPKKPGCSSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQ 60 M S S G C S A L E++KL E RERQ Sbjct: 921 MKLPSSSTWGQQSNTTACQSQATLSLA----EIQKLEEE-----------------RERQ 959 Query: 61 LREEAERERRQLADRLRSKWEAQR---------------SRELRQLQEEMQREREAEIRQ 105 LREE R++R+L L+ + + Q+ ++ L ++Q+E R+ + Sbjct: 960 LREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQ----- 1014 Query: 106 LLRWKEAEQRQLQQLLHRERD 126 K+ +Q+Q Q +R R+ Sbjct: 1015 ----KQQQQQQQHQQPNRARN 1031 Score = 33.1 bits (74), Expect = 2.3 Identities = 45/237 (18%), Positives = 94/237 (39%), Gaps = 21/237 (8%) Query: 395 QAENKQLRRAGCPYQADEKVKR----LKVKRAELTGLARRLADRARKLQETNLRAVSAPI 450 Q + + LRR + +E+ ++ L+ + E AR + R+L+E LR Sbjct: 814 QQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAA 873 Query: 451 PGESCAGLELCQVFARQRARDLSEQASAPLAKDKQIEELRQECHLLQARVASGPCSDLHT 510 + QR ++L Q +++++ +Q+ L Q ++ S + Sbjct: 874 RLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQS 933 Query: 511 GRGGPCTQ-WLNVRDLDRL-----------QRESQREVLR-LQRQLMLQQGNGGAWPEAG 557 +Q L++ ++ +L QR QRE+++ LQ+Q QQ W Sbjct: 934 NTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVS 993 Query: 558 GQSATCEEVRRQMLALERELDQRRRECQELGAQAAPARRRGEEAETQLQAALLKNAW 614 S T + +L +++E ++ ++ Q+ Q R + L ++ + W Sbjct: 994 KPSGT----TKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHSNLHTSIGNSVW 1046 Score = 32.7 bits (73), Expect = 3.0 Identities = 52/245 (21%), Positives = 95/245 (38%), Gaps = 48/245 (19%) Query: 481 AKDKQIEELRQECHLLQARVASGPCSDLHTGRG---------GPCTQWLNVRDLDRLQRE 531 A+ Q ++ +Q+ H R + S+LHT G GP QW + DL Sbjct: 1010 ARQMQKQQQQQQQHQQPNRARNNTHSNLHTSIGNSVWGSINTGPPNQWAS--DL------ 1061 Query: 532 SQREVLRLQRQLMLQQGNGGAWPEA----GGQSATCEEVRRQMLALERELDQRRR---EC 584 V + + N G W +A G +++T + L+ + R+ E Sbjct: 1062 ----VSSIWSNADTKNSNMGFWDDAVKEVGPRNSTNKNKNNASLSKSVGVSNRQNKKVEE 1117 Query: 585 QELGAQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAE---NSEVRG 641 +E + + ++ TQ +L +A N + ++++VE+ + +R Sbjct: 1118 EEKLLKLFQGVNKAQDGFTQWCEQML-HALNTANNLDVPTFVSFLKEVESPYEVHDYIRA 1176 Query: 642 HLGRACQERDASGLIAEQLLQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQALQCRPGH 701 +LG + ++ + E+ +Q A Q +QQQL + Q Q P Sbjct: 1177 YLGDTSEAKEFAKQFLERRAKQKANQQRQQQQLPQQQQ----------------QQPPQQ 1220 Query: 702 PPEQP 706 PP+QP Sbjct: 1221 PPQQP 1225 >gi|148746195 trichohyalin [Homo sapiens] Length = 1943 Score = 59.7 bits (143), Expect = 2e-08 Identities = 42/125 (33%), Positives = 72/125 (57%), Gaps = 7/125 (5%) Query: 27 ENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSR 86 + +RRE ++ R E + ER + R + RE+QLR E E ERR+ R R + E +R + Sbjct: 318 QEERREQQE-RREQQEERREQQLRREQEERREQQLRREQEEERREQQLR-REQEEERREQ 375 Query: 87 ELR---QLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEEL 143 +LR QL+ E Q RE ++R+ + + +Q + +Q L RE+ +R+ ++L+R+ EE Sbjct: 376 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQ--LRREQQLRREQEEER 433 Query: 144 VNRGH 148 + H Sbjct: 434 HEQKH 438 Score = 58.9 bits (141), Expect = 4e-08 Identities = 54/175 (30%), Positives = 83/175 (47%), Gaps = 28/175 (16%) Query: 26 LENQRRELEKLRAELEAERAGWRAERRRFAARERQ--------------LREEAERERRQ 71 LE Q R+ E+L+ E E + E+RR RERQ LREE E+ RRQ Sbjct: 1076 LERQYRKEEELQQE-EEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQ 1134 Query: 72 LADRLRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQ 131 +R + E + E + L+EE ++ R E+ + R +E Q++ +QLL RE RQ Sbjct: 1135 ELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLL-REEQEKRRQ 1193 Query: 132 ARELQRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIR 186 RE Q + EEL + + R R ++ + L+WQ + E+ +R Sbjct: 1194 ERERQYREEEEL------------QRQKRKQRYRDEDQRSDLKWQWEPEKENAVR 1236 Score = 58.5 bits (140), Expect = 5e-08 Identities = 49/173 (28%), Positives = 87/173 (50%), Gaps = 15/173 (8%) Query: 27 ENQRRELEKLRAE--LEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQR 84 E +R +L K E LE ER R +R + R++ L+ E ER +++L + E + Sbjct: 543 EERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRL 602 Query: 85 SRE-LRQLQEEMQRER--------EAEIRQLLRWKEAEQRQLQQLLHRERD-GVVRQARE 134 RE + +L++E +RE+ E +QLL+ +E E+R+ QQL +++ R RE Sbjct: 603 KREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKRE 662 Query: 135 LQRQLAEELVNRGHCSRPGASEVS---AAQCRCRLQEVLAQLRWQTDGEQAAR 184 + + E+ + R H E++ Q R R++ + + +WQ + E AR Sbjct: 663 EEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADAR 715 Score = 57.8 bits (138), Expect = 9e-08 Identities = 38/118 (32%), Positives = 66/118 (55%), Gaps = 3/118 (2%) Query: 26 LENQRRELEKL-RAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQR 84 L+ + +L KL R EL ER +++R RE+QLR + E ERR+ + R + E + Sbjct: 271 LQEEEEQLRKLERQELRRERQEEEQQQQRLR-REQQLRRKQEEERREQQEERREQQERRE 329 Query: 85 SRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEE 142 +E R+ +++++RE+E Q LR ++ E+R+ QQL + + Q ++QL E Sbjct: 330 QQEERR-EQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRRE 386 Score = 57.0 bits (136), Expect = 1e-07 Identities = 45/130 (34%), Positives = 66/130 (50%), Gaps = 17/130 (13%) Query: 27 ENQRRELEKLRAELEAERAGWRAERRRFAARERQ--------------LREEAERERRQL 72 E Q RE E+L+ E E + G E RR ERQ LREE E+ RRQ Sbjct: 1047 ERQYREEEELQQE-EEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQE 1105 Query: 73 ADRLRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQA 132 +R + E + E + L+EE ++ R E+ + R +E Q++ +QLL E + R+ Sbjct: 1106 RERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPE--KRRR 1163 Query: 133 RELQRQLAEE 142 +EL+RQ EE Sbjct: 1164 QELERQYREE 1173 Score = 56.6 bits (135), Expect = 2e-07 Identities = 43/117 (36%), Positives = 63/117 (53%), Gaps = 2/117 (1%) Query: 27 ENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSR 86 E QR E EK R + E ER +R E + E+ LREE E+ RRQ +R K + + + Sbjct: 912 ELQREEREKRRRQ-EQERQ-YREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQK 969 Query: 87 ELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEEL 143 E + L EE ++ R E + R +E Q++ +QLL ER+ RQ E Q + +EL Sbjct: 970 EEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDEL 1026 Score = 55.8 bits (133), Expect = 3e-07 Identities = 56/172 (32%), Positives = 86/172 (50%), Gaps = 12/172 (6%) Query: 29 QRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSRE- 87 +RREL +LR + E+ R ER+ +R +EE E+E R+ LR + E + E Sbjct: 211 RRRELLELRRKGREEKQQQRRERQ-----DRVFQEEEEKEWRKRETVLRKEEEKLQEEEP 265 Query: 88 --LRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEELVN 145 R+LQEE ++ R+ E RQ LR + E+ Q QQ L RE+ + R+ E +R+ EE Sbjct: 266 QRQRELQEEEEQLRKLE-RQELRRERQEEEQQQQRLRREQQ-LRRKQEEERREQQEE--R 321 Query: 146 RGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAALEVERQ 197 R R E Q R QE + + + + E+ R + L+ E ER+ Sbjct: 322 REQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERR 373 Score = 55.8 bits (133), Expect = 3e-07 Identities = 51/179 (28%), Positives = 86/179 (48%), Gaps = 19/179 (10%) Query: 27 ENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSR 86 + +RRE ++LR E E R + RE+QLR E E ERR+ +LR + + +R + Sbjct: 331 QEERRE-QQLRREQEERREQQLRREQEEERREQQLRREQEEERRE--QQLRREQQLRREQ 387 Query: 87 ELR---QLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRER-----DGVVRQARELQRQ 138 +LR QL+ E Q RE ++R+ + + +Q + +Q L RE+ + Q R QR Sbjct: 388 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRL 447 Query: 139 LAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAALEVERQ 197 E+ R R +E R ++ + + + D E+ R R+L+ E R+ Sbjct: 448 KREQEERRDWLKREEETE--------RHEQERRKQQLKRDQEEERRERWLKLEEEERRE 498 Score = 55.5 bits (132), Expect = 4e-07 Identities = 44/130 (33%), Positives = 65/130 (50%), Gaps = 17/130 (13%) Query: 27 ENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAE--------------RERRQL 72 E Q R+ ++L+ E E + E+RR RERQ REE E RRQ Sbjct: 1017 ERQYRKKDELQQE-EEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQE 1075 Query: 73 ADRLRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQA 132 +R K E + E + L+EE ++ R E + R +E Q++ +QLL ER+ R+ Sbjct: 1076 LERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREERE--KRRR 1133 Query: 133 RELQRQLAEE 142 +EL+RQ EE Sbjct: 1134 QELERQYREE 1143 Score = 54.3 bits (129), Expect = 1e-06 Identities = 44/131 (33%), Positives = 64/131 (48%), Gaps = 15/131 (11%) Query: 27 ENQRRELEKLRAELEAERAGWRAERRRFAARERQLR--------------EEAERERRQL 72 E Q RE E+L+ E E + E+RR RERQ R EE E+ RRQ Sbjct: 927 ERQYREEEQLQQE-EEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQE 985 Query: 73 ADRLRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQA 132 ++ + E + E + L+EE ++ R E + R K+ Q++ +QLL ER+ Q Sbjct: 986 REKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQE 1045 Query: 133 RELQRQLAEEL 143 RE Q + EEL Sbjct: 1046 RERQYREEEEL 1056 Score = 53.9 bits (128), Expect = 1e-06 Identities = 45/175 (25%), Positives = 80/175 (45%), Gaps = 11/175 (6%) Query: 27 ENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSR 86 + QRRE + R E E WR E +L+EE + +R+L + + +R Sbjct: 227 QQQRRERQD-RVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQE 285 Query: 87 ELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEELVNR 146 R+ QEE Q+++ Q LR K+ E+R+ QQ RE+ ++ RE Q + E+ + R Sbjct: 286 LRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQ----QERREQQEERREQQLRR 341 Query: 147 GHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAALEVERQLFLK 201 E Q R +E + + + + E+ R + L+ ++ R+ L+ Sbjct: 342 EQ------EERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLR 390 Score = 53.9 bits (128), Expect = 1e-06 Identities = 56/188 (29%), Positives = 85/188 (45%), Gaps = 22/188 (11%) Query: 27 ENQRRELEKLRAELEAERAGWRAERRRFAARERQ--------------LREEAERERRQL 72 E Q R+ +KL+ + E + G E+RR RE++ LREE E+ RRQ Sbjct: 957 ERQYRKDKKLQQK-EEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQE 1015 Query: 73 ADRLRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQA 132 +R K + + E + L+EE ++ R E + R +E Q++ +QLL ER+ RQ Sbjct: 1016 WERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQE 1075 Query: 133 RELQRQLAEELVNRGH---CSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQ 189 E Q + EEL P + +CR +E L Q Q E+ + R Sbjct: 1076 LERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRR--- 1132 Query: 190 AALEVERQ 197 E+ERQ Sbjct: 1133 -RQELERQ 1139 Score = 53.9 bits (128), Expect = 1e-06 Identities = 51/183 (27%), Positives = 87/183 (47%), Gaps = 26/183 (14%) Query: 27 ENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSR 86 E Q R E+ R L+ E+ R E R E QLR+E E+E+ + +R R E ++ R Sbjct: 1697 EQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLR 1756 Query: 87 ELRQLQEEMQREREAEIR-----------QLLRWKEA-----------EQRQLQQLLHRE 124 R+ Q+ ++ER+ + R Q LR +E+ ++R+ QQL ++ Sbjct: 1757 PEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQ 1816 Query: 125 RDGVVR-QARELQRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAA 183 RDG R + +LQ + E+ + + + A E A Q + R +E Q WQ + ++ Sbjct: 1817 RDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREE---QELWQEEEQKRR 1873 Query: 184 RIR 186 + R Sbjct: 1874 QER 1876 Score = 52.4 bits (124), Expect = 4e-06 Identities = 41/109 (37%), Positives = 66/109 (60%), Gaps = 17/109 (15%) Query: 30 RRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSRELR 89 RRE ++LR + E ER + ERR E+Q R E + ERR+ +LR + E +R ++LR Sbjct: 301 RRE-QQLRRKQEEERREQQEERR-----EQQERREQQEERRE--QQLRREQEERREQQLR 352 Query: 90 QLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQ 138 + QEE +RE Q LR ++ E+R+ QQL R+ +R+ ++L+R+ Sbjct: 353 REQEEERRE------QQLRREQEEERREQQL---RREQQLRREQQLRRE 392 Score = 51.6 bits (122), Expect = 6e-06 Identities = 55/188 (29%), Positives = 86/188 (45%), Gaps = 28/188 (14%) Query: 26 LENQRRELE-------KLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADR--L 76 L Q RE + K R E + + G + RR R+R+ REE ++ RRQ +R L Sbjct: 1652 LRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRR-QERDRKFREEEQQLRRQERERKFL 1710 Query: 77 RSKWEAQRSRELRQLQEEMQREREAEIRQLLRWK------EAEQ----RQLQQLLHRERD 126 + + + +R R+ +EE Q +E E QL R + E EQ R+ QQL +ERD Sbjct: 1711 QEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERD 1770 Query: 127 GVVRQARELQRQLAEELVNRGHCSRPGASEVSAAQCR----CRLQEVLAQLRWQTD---- 178 R+ +L+++ E+ + R E Q R R Q+ + RW+ + Sbjct: 1771 RKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQL 1830 Query: 179 GEQAARIR 186 EQ R+R Sbjct: 1831 EEQEQRLR 1838 Score = 51.2 bits (121), Expect = 8e-06 Identities = 53/182 (29%), Positives = 88/182 (48%), Gaps = 20/182 (10%) Query: 27 ENQRRELEKLRAELEAERAGWRAER-RRFAARERQLREEAERERRQLADRLRSKWEAQRS 85 E + R E R LE E+ R +R R+F E+QLR + ER +++ DR R E ++ Sbjct: 1505 EQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQ-ERGQQRRQDRDRKFREEEQL 1563 Query: 86 RELRQLQEEMQREREAEIR---QLLRWKEAEQRQL-----------QQLLHRERDGVVRQ 131 R+ R+ Q+ ++ER+ + R Q +R +E E++ + QQ L +ERD R+ Sbjct: 1564 RQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFRE 1623 Query: 132 ARELQRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAA 191 +L ++ E+ ++R R E + + R QE QLR D + + LQ Sbjct: 1624 DEQLLQEREEQQLHRQERDRKFLEE----EPQLRRQEREQQLRHDRDRKFREEEQLLQEG 1679 Query: 192 LE 193 E Sbjct: 1680 EE 1681 Score = 50.8 bits (120), Expect = 1e-05 Identities = 41/125 (32%), Positives = 67/125 (53%), Gaps = 16/125 (12%) Query: 27 ENQRRELEKLRAELEAERAGW-----RAERRRFAARERQLREEAERERRQLADRLRSKWE 81 E +RRE ++L+ E E ER W ER R++QL+ + E ERR+ +L E Sbjct: 439 EQERRE-QRLKREQE-ERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLE---E 493 Query: 82 AQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAE 141 +R + + +++++RE+E Q L+ +E E+R LQQ L E +Q R Q + E Sbjct: 494 EERREQQERREQQLRREQEERREQRLKRQEEEER-LQQRLRSE-----QQLRREQEERRE 547 Query: 142 ELVNR 146 +L+ R Sbjct: 548 QLLKR 552 Score = 50.4 bits (119), Expect = 1e-05 Identities = 57/196 (29%), Positives = 83/196 (42%), Gaps = 38/196 (19%) Query: 27 ENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRS---KWEAQ 83 E Q R ++L+ E E ER R +R ER+ +E AE E+ Q +R++S KW+ Q Sbjct: 650 EQQERREQRLKREEEEERLEQRLKREH--EEERREQELAEEEQEQARERIKSRIPKWQWQ 707 Query: 84 RSREL-------------------RQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRE 124 E RQ QEE +R RE+E L+W+E E+ QQ + Sbjct: 708 LESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESE----LQWQEEERAHRQQQEEEQ 763 Query: 125 RDGVVRQARELQRQLAEELVNRGH---CSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQ 181 R Q + AEE RG +RP E Q R ++ Q R+ + E+ Sbjct: 764 RRDFTWQWQ------AEEKSERGRQRLSARPPLREQRERQLRAEERQQREQ-RFLPEEEE 816 Query: 182 AARIRYLQAALEVERQ 197 + R + E E Q Sbjct: 817 KEQRRRQRREREKELQ 832 Score = 49.3 bits (116), Expect = 3e-05 Identities = 57/187 (30%), Positives = 84/187 (44%), Gaps = 19/187 (10%) Query: 27 ENQRRELEKLRAELEAERAGWRAERRRFAAR-------ERQLREEAERERRQLADRLRSK 79 E Q R ++LR E E ER R +R+ R E+QLR E E R QL R K Sbjct: 498 EQQERREQQLRREQE-ERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEK 556 Query: 80 WEAQRSRELRQLQEEMQR-----EREAEIRQLLRWKEAEQRQLQQLLHRER----DGVVR 130 Q RE R +E+ +R +RE E RQ R K ++ +L+Q L RE + R Sbjct: 557 RLEQERREQRLKREQEERRDQLLKREEERRQQ-RLKREQEERLEQRLKREEVERLEQEER 615 Query: 131 QARELQRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQA 190 + + L+R+ EE R + E Q R Q+ + R + + E+ + L+ Sbjct: 616 REQRLKREEPEE-ERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKR 674 Query: 191 ALEVERQ 197 E ER+ Sbjct: 675 EHEEERR 681 Score = 49.3 bits (116), Expect = 3e-05 Identities = 53/175 (30%), Positives = 80/175 (45%), Gaps = 16/175 (9%) Query: 27 ENQRRELE-KLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADR--LRSKWEAQ 83 + +RRE E + + E A R E+RR + Q E++ER R++L+ R LR + E Q Sbjct: 738 KRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQ 797 Query: 84 RSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEEL 143 E RQ +E+ E E Q R + +++LQ L E+ Q RE +QL EE Sbjct: 798 LRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQ----LQRRERAQQLQEE- 852 Query: 144 VNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAALEVERQL 198 G E + R + Q + RWQ + E+ R L A ++ QL Sbjct: 853 -------EDGLQE-DQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQL 899 Score = 49.3 bits (116), Expect = 3e-05 Identities = 59/198 (29%), Positives = 91/198 (45%), Gaps = 33/198 (16%) Query: 26 LENQRRELEKLRAE------LEAERAGWRAERRRFAARERQLR-EEAERERRQLADR--- 75 L +R E + R E LE ++ + + R+F E+QLR +E +++ RQ DR Sbjct: 1563 LRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFR 1622 Query: 76 -----LRSKWEAQRSRELRQ---LQEEMQ---REREAEIRQLLRWKEAEQRQL------Q 118 L+ + E Q R+ R L+EE Q +ERE ++R K E+ QL Q Sbjct: 1623 EDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQ 1682 Query: 119 QLLHRERDGVVRQARELQRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTD 178 QL +ERD R+ RE ++QL + R + + R +E QLR +T+ Sbjct: 1683 QLRRQERD---RKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEE---QLRQETE 1736 Query: 179 GEQAARIRYLQAALEVER 196 EQ R + LE E+ Sbjct: 1737 QEQLRRQERYRKILEEEQ 1754 Score = 48.9 bits (115), Expect = 4e-05 Identities = 44/140 (31%), Positives = 66/140 (47%), Gaps = 26/140 (18%) Query: 27 ENQRRELEKLRAELEAERAGW-----RAERRRFAARERQLREEAERERRQ---------- 71 E +RR+ + R + E R W R + RE+QLR E E R Q Sbjct: 468 EQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEER 527 Query: 72 LADRLRSKWEAQRSRELRQLQ-----EEMQREREAEIRQLLRWKEAEQRQLQQLLHRERD 126 L RLRS+ + +R +E R+ Q EE + E+E R+ R K ++ + QLL RE + Sbjct: 528 LQQRLRSEQQLRREQEERREQLLKREEEKRLEQE---RREQRLKREQEERRDQLLKREEE 584 Query: 127 GVVRQARELQRQLAEELVNR 146 R+ + L+R+ E L R Sbjct: 585 ---RRQQRLKREQEERLEQR 601 Score = 48.5 bits (114), Expect = 5e-05 Identities = 49/162 (30%), Positives = 76/162 (46%), Gaps = 21/162 (12%) Query: 31 RELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSRELRQ 90 RE E+L E E ++ + R+F E+QLR + ER+R+ LRS+ ++ E Q Sbjct: 1464 REEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQ-ERDRKFREQELRSQEPERKFLEEEQ 1522 Query: 91 LQEEMQRERE--AEIRQLLRWKEAEQR------------QLQQLLHRERDGVVRQARELQ 136 QR+R+ E +QL R + +QR QL+Q RE + RQ R+ + Sbjct: 1523 QLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQ--EREEQQLSRQERDRK 1580 Query: 137 RQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTD 178 +L E+ V R R + + + R QE QLR + D Sbjct: 1581 FRLEEQKVRRQEQERKFMED----EQQLRRQEGQQQLRQERD 1618 Score = 47.4 bits (111), Expect = 1e-04 Identities = 46/130 (35%), Positives = 68/130 (52%), Gaps = 18/130 (13%) Query: 27 ENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAER-ERRQLA-------DRLRS 78 E Q+RE L E E E+ R +RR +E Q EE E+ +RR+ A D L+ Sbjct: 802 ERQQREQRFLPEEEEKEQ---RRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQE 858 Query: 79 KWEAQRSRELRQLQE---EMQREREAEIRQLLRWKEAEQRQL---QQLLHRERDGVVRQA 132 E +RS+E R+ Q+ +++ ER+ R L K A Q QL QQLL E + + R+ Sbjct: 859 DQERRRSQEQRRDQKWRWQLEEERKRR-RHTLYAKPALQEQLRKEQQLLQEEEEELQREE 917 Query: 133 RELQRQLAEE 142 RE +R+ +E Sbjct: 918 REKRRRQEQE 927 Score = 47.0 bits (110), Expect = 2e-04 Identities = 33/100 (33%), Positives = 51/100 (51%), Gaps = 8/100 (8%) Query: 50 ERRRFAARERQLREEA---ERERRQLADRLRSKWEAQRSRELRQLQEEMQREREAEIRQL 106 ++RRF R+RQL EE R++RQ +R ++ E Q ++ R Q + QR E RQ Sbjct: 118 DQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQR 177 Query: 107 LRWKEAEQR-----QLQQLLHRERDGVVRQARELQRQLAE 141 W+E E+R QLQ E + + + +R+L E Sbjct: 178 QEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLE 217 Score = 46.6 bits (109), Expect = 2e-04 Identities = 49/176 (27%), Positives = 77/176 (43%), Gaps = 9/176 (5%) Query: 27 ENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERR-----QLADRLRSKWE 81 E Q R ++LR E + R + R + RE+QLR E E ER Q R K E Sbjct: 392 EQQLRREQQLRREQQLRREQ-QLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKRE 450 Query: 82 AQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAE 141 + R+ + +EE +R + +Q L+ + E+R+ + L E + +Q R ++QL Sbjct: 451 QEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERR-EQQLRR 509 Query: 142 ELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAALEVERQ 197 E R E Q R R ++ L R Q + + R + LE ER+ Sbjct: 510 EQEERREQRLKRQEEEERLQQRLRSEQQLR--REQEERREQLLKREEEKRLEQERR 563 Score = 45.8 bits (107), Expect = 3e-04 Identities = 41/132 (31%), Positives = 64/132 (48%), Gaps = 16/132 (12%) Query: 27 ENQRRELEKLRAELEAERAG--------------WRAERRRFAARERQL-REEAERERRQ 71 + QRR+ +K R +LE ER R E++ E +L REE E+ RRQ Sbjct: 866 QEQRRD-QKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQ 924 Query: 72 LADRLRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQ 131 +R + E + E + L+EE ++ R E + R + Q++ +QLL E + RQ Sbjct: 925 EQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQ 984 Query: 132 ARELQRQLAEEL 143 RE + + EEL Sbjct: 985 EREKKYREEEEL 996 Score = 45.8 bits (107), Expect = 3e-04 Identities = 39/152 (25%), Positives = 73/152 (48%), Gaps = 28/152 (18%) Query: 26 LENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSK------ 79 LE Q RE E+L+ E E + +RR+ RERQ REE E +R++ R R + Sbjct: 1166 LERQYREEEELQQEEEQLLREEQEKRRQ--ERERQYREEEELQRQKRKQRYRDEDQRSDL 1223 Query: 80 ---WEAQR---------------SRELRQLQEEMQREREA--EIRQLLRWKEAEQRQLQQ 119 WE ++ + + RQL++ R+R++ +++ LL ++ R+ ++ Sbjct: 1224 KWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQER 1283 Query: 120 LLHRERDGVVRQARELQRQLAEELVNRGHCSR 151 ++RD + +L+R+ +E R S+ Sbjct: 1284 RRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQ 1315 Score = 44.7 bits (104), Expect = 8e-04 Identities = 42/129 (32%), Positives = 66/129 (51%), Gaps = 6/129 (4%) Query: 24 AVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAE-RERRQLADRLRSKWEA 82 ++L+++R+E ++ R E + +RR R+ Q RE AE E+ + +RL + Sbjct: 108 SLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQ 167 Query: 83 QRSREL-RQLQEEMQR-EREAEIRQLLRWKEAEQRQL---QQLLHRERDGVVRQARELQR 137 +R EL RQ QE +R ER AE QL K E + +QL RE + R+ RE ++ Sbjct: 168 RRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQ 227 Query: 138 QLAEELVNR 146 Q E +R Sbjct: 228 QQRRERQDR 236 Score = 44.3 bits (103), Expect = 0.001 Identities = 40/149 (26%), Positives = 69/149 (46%), Gaps = 14/149 (9%) Query: 29 QRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSREL 88 Q RE ++LR + + W E+ + +E++LR+E +R+ R A+ + E R E Sbjct: 1805 QEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYR--AEEQFATQEKSRREEQ 1862 Query: 89 RQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEELVNRGH 148 QEE Q+ R+ R+ LR + ++Q ++ H RQ E++ Q E G Sbjct: 1863 ELWQEEEQKRRQERERK-LREEHIRRQQKEEQRH-------RQVGEIKSQ---EGKGHGR 1911 Query: 149 CSRPGASEVSAAQCRCR-LQEVLAQLRWQ 176 PG + ++ R L E + + R Q Sbjct: 1912 LLEPGTHQFASVPVRSSPLYEYIQEQRSQ 1940 Score = 43.9 bits (102), Expect = 0.001 Identities = 49/181 (27%), Positives = 84/181 (46%), Gaps = 27/181 (14%) Query: 27 ENQRRELEKLRAELEAERAGWRAERRR----------FAARERQLREEAERERRQLADRL 76 E + R E+ R LE E+ R ER R RE+QLR++ +R+ R+ +L Sbjct: 1364 EEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQL 1423 Query: 77 RSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQ 136 + +R R+ R +EE Q R+ R+ L E++QL+Q HR+ R+ +L Sbjct: 1424 SRQ---ERDRKFR--EEEQQVRRQERERKFLE----EEQQLRQERHRK----FREEEQLL 1470 Query: 137 RQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAALEVER 196 ++ E+ ++R R E + + R QE + R Q Q ++L+ ++ R Sbjct: 1471 QEREEQQLHRQERDRKFLEE----EQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHR 1526 Query: 197 Q 197 Q Sbjct: 1527 Q 1527 Score = 43.5 bits (101), Expect = 0.002 Identities = 39/134 (29%), Positives = 62/134 (46%), Gaps = 7/134 (5%) Query: 50 ERRRFAARERQLREEAERERRQLADRLRSKWEAQRSRE-LRQLQEEMQREREAEIRQLLR 108 ERRR+ R+R EE + ER + + R ++Q ++ LR+ +EE +R +E + + Sbjct: 1282 ERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREE 1341 Query: 109 WKEAEQRQLQQLLHRERDGVVRQA----RELQRQLAEELVNRGHCSRPGASEVSAAQCRC 164 + ++R+ Q L +ERD R+ +E R+ EE R Q RC Sbjct: 1342 EQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRC 1401 Query: 165 RLQEVLAQLRWQTD 178 QE QLR D Sbjct: 1402 --QEREQQLRQDRD 1413 Score = 43.1 bits (100), Expect = 0.002 Identities = 41/139 (29%), Positives = 63/139 (45%), Gaps = 16/139 (11%) Query: 27 ENQRRELEKLRAELEAERAGWRAERRRFAARE--RQLREE----AERERRQLADRLRS-- 78 E Q R E+ R E E+ E ++ ++E R+ REE ERE +QL + R Sbjct: 1761 EQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGK 1820 Query: 79 -KWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQR 137 +WE E QL+E+ QR R+ RQ ++ EQ Q+ RE + ++ + +R Sbjct: 1821 YRWE----EEQLQLEEQEQRLRQERDRQ---YRAEEQFATQEKSRREEQELWQEEEQKRR 1873 Query: 138 QLAEELVNRGHCSRPGASE 156 Q E + H R E Sbjct: 1874 QERERKLREEHIRRQQKEE 1892 Score = 42.7 bits (99), Expect = 0.003 Identities = 46/159 (28%), Positives = 76/159 (47%), Gaps = 13/159 (8%) Query: 27 ENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQR-S 85 E +RR+ + L++E + ER + R + RE++L+ E E ER L RL+ + E +R Sbjct: 626 EEERRQ-QLLKSEEQEERRQQQLRREQQERREQRLKREEEEER--LEQRLKREHEEERRE 682 Query: 86 RELRQLQEEMQREREAEIRQLLRWK---EAEQRQLQQLLHRERDGVVRQARELQRQLAEE 142 +EL + ++E RER +W+ EA+ RQ ++ R R +Q + +RQ EE Sbjct: 683 QELAEEEQEQARERIKSRIPKWQWQLESEADARQ-SKVYSRPR----KQEGQRRRQEQEE 737 Query: 143 LVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQ 181 R S E A + + +E WQ E+ Sbjct: 738 KRRRRE-SELQWQEEERAHRQQQEEEQRRDFTWQWQAEE 775 Score = 42.4 bits (98), Expect = 0.004 Identities = 41/133 (30%), Positives = 64/133 (48%), Gaps = 17/133 (12%) Query: 27 ENQRRELEKLRAELEA-ERAGWRAERRRFAARERQLREEAER-ERRQLADRLRS------ 78 + Q REL + + E ER R +RR RQ +E ER ERR ++L+S Sbjct: 142 QEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHET 201 Query: 79 ----KWEAQRSRELRQL-----QEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVV 129 E R REL +L +E+ Q+ RE + R +E E R+ + +L +E + + Sbjct: 202 EEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQ 261 Query: 130 RQARELQRQLAEE 142 + + QR+L EE Sbjct: 262 EEEPQRQRELQEE 274 Score = 42.4 bits (98), Expect = 0.004 Identities = 45/173 (26%), Positives = 80/173 (46%), Gaps = 16/173 (9%) Query: 27 ENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLAD----RLRSKWEA 82 E +R+ LE+ + + +R E + RE Q ER+R+ L + R + + Sbjct: 1443 ERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRK 1502 Query: 83 QRSRELRQ-------LQEEMQREREAEIRQLLRWKEAEQRQLQ-QLLHRERDGVVRQARE 134 R +ELR L+EE Q R+ R+ L+ ++ +RQ + Q ++RD R+ + Sbjct: 1503 FREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQ 1562 Query: 135 LQRQLAEELVNRGHCSRPGASE---VSAAQCRCRLQEVLAQLRWQTDGEQAAR 184 L+++ E+ ++R R E V + + E QLR Q +G+Q R Sbjct: 1563 LRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQ-EGQQQLR 1614 Score = 41.2 bits (95), Expect = 0.008 Identities = 46/144 (31%), Positives = 63/144 (43%), Gaps = 29/144 (20%) Query: 29 QRRELEKLRAELEAERAGWRAERRRFAARER------QLREEAERERRQLADRLRSKWEA 82 QRRE EK LE E R ER + E Q R ++ +RR R + + E Sbjct: 823 QRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEER 882 Query: 83 QRSRE------------------LRQLQEEMQR-EREAEIRQLLRWKEAEQRQLQ----Q 119 +R R L++ +EE+QR ERE RQ + E+ QLQ Q Sbjct: 883 KRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQ 942 Query: 120 LLHRERDGVVRQARELQRQLAEEL 143 LL ER+ RQ RE Q + ++L Sbjct: 943 LLREEREKRRRQERERQYRKDKKL 966 Score = 39.3 bits (90), Expect = 0.032 Identities = 59/240 (24%), Positives = 102/240 (42%), Gaps = 35/240 (14%) Query: 527 RLQRESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRRQMLALERE--LDQRRREC 584 RL+R+ + E RLQ++L +Q EE R Q+L E E L+Q RRE Sbjct: 518 RLKRQEEEE--RLQQRLRSEQQ----------LRREQEERREQLLKREEEKRLEQERRE- 564 Query: 585 QELGAQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLG 644 Q L + R + + E + + LK E+ RL+ + +++ E E E Sbjct: 565 QRLKREQEERRDQLLKREEERRQQRLKR----EQEERLEQR---LKREEVERLEQEERRE 617 Query: 645 RACQERDASGLIAEQLLQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQALQCRPGHPPE 704 + + + +QLL+ + + RQQQL+R+ Q+ +E + L+ R E Sbjct: 618 QRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHE 677 Query: 705 QPWETSQMPESQVK------GSRRPKFHARPEDYA-------VSQPNRDIQEKREASLEE 751 + ++ E + + SR PK+ + E A S+P + ++R EE Sbjct: 678 EERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEE 737 Score = 39.3 bits (90), Expect = 0.032 Identities = 42/146 (28%), Positives = 70/146 (47%), Gaps = 26/146 (17%) Query: 27 ENQRRELEKLRAELEAERAGWRAERRRFAARERQLREE--------AERERRQLADR-LR 77 E +RR ++ E R E++ R+R+ +EE E+ RRQ DR R Sbjct: 1280 EQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFR 1339 Query: 78 SKWEAQRSRELRQL--QEEMQREREAEIR------------QLLRWKEAEQRQL---QQL 120 + + + RE + L QE ++ RE E+R Q LR +E E++ L QQL Sbjct: 1340 EEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQL 1399 Query: 121 LHRERDGVVRQARELQRQLAEELVNR 146 +ER+ +RQ R+ + + E+ ++R Sbjct: 1400 RCQEREQQLRQDRDRKFREEEQQLSR 1425 Score = 37.4 bits (85), Expect = 0.12 Identities = 52/243 (21%), Positives = 102/243 (41%), Gaps = 24/243 (9%) Query: 523 RDLDRLQRESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRRQMLALERELDQRRR 582 R+ + + E + E R +++L +Q W + ++ E+ RR+ L+R+ ++ RR Sbjct: 427 REQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQ-QLKRDQEEERR 485 Query: 583 ECQELGAQAAPARRRGEEAETQL----QAALLKNAWLAEENGRLQAKTDWVRKVEAENSE 638 E + L + R + E E QL + + EE RLQ + +++ E E Sbjct: 486 E-RWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEE 544 Query: 639 VRGHLGRACQERDASGLIAEQLL---------QQAARGQDRQQQLQRDPQKALCDLHPSW 689 R L + +E+ EQ L Q R ++R+QQ + Q+ + Sbjct: 545 RREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKR 604 Query: 690 KEIQALQCRPGHPPEQPWETSQMPESQVKGSRRPKF--HARPEDYAVSQPNRDIQEKREA 747 +E++ L+ ++ ++ + + RR + E+ Q R+ QE+RE Sbjct: 605 EEVERLE-------QEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQ 657 Query: 748 SLE 750 L+ Sbjct: 658 RLK 660 Score = 37.0 bits (84), Expect = 0.16 Identities = 21/74 (28%), Positives = 36/74 (48%) Query: 27 ENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSR 86 E ++ +LE+ L ER +FA +E+ REE E + + R + + R Sbjct: 1824 EEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREE 1883 Query: 87 ELRQLQEEMQRERE 100 +R+ Q+E QR R+ Sbjct: 1884 HIRRQQKEEQRHRQ 1897 Score = 35.8 bits (81), Expect = 0.35 Identities = 49/217 (22%), Positives = 88/217 (40%), Gaps = 30/217 (13%) Query: 561 ATCEEVRRQMLALERELDQRRRECQELGAQAAPARRRGEEAETQLQAALLKNAWLAEENG 620 A C+ + +E DQRR E ++ + P +RR ++ + Q + L + +E+ Sbjct: 101 ARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQ-ERELAEGEEQSEKQE 159 Query: 621 RLQ-------------AKTDWVRKVE--AENSEVRGHLGRACQE-RDASGLIAEQLLQQA 664 RL+ + +W + E AE +++ G +E D L +LL+ Sbjct: 160 RLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELR 219 Query: 665 ARGQDRQQQLQRDPQKALC--DLHPSW--------KEIQALQCRPGHPPEQPWETSQMPE 714 +G++ +QQ +R+ Q + + W KE + LQ P++ E + E Sbjct: 220 RKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQ---EEEPQRQRELQEEEE 276 Query: 715 SQVKGSRRPKFHARPEDYAVSQPNRDIQEKREASLEE 751 K R+ R E+ Q R Q+ R EE Sbjct: 277 QLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEE 313 Score = 35.4 bits (80), Expect = 0.46 Identities = 54/239 (22%), Positives = 96/239 (40%), Gaps = 31/239 (12%) Query: 523 RDLDRLQRESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRRQMLALERELDQRR- 581 ++L+R RE + EV + + QL+ ++ E Q EE++++ L RE ++R Sbjct: 1134 QELERQYREEE-EVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRR 1192 Query: 582 -------RECQELGAQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVEA 634 RE +EL Q R R E+ + L+ W E + + V Sbjct: 1193 QERERQYREEEELQRQKRKQRYRDEDQRSDLK-------WQWEPEKENAVRDNKVYCKGR 1245 Query: 635 ENSEVR----GHLGRACQERDASGLIAEQLLQQAARGQDRQQQLQRDPQKALCDLHPSWK 690 EN + R L ++D L+ EQ Q+ R Q+R++ QRD + Sbjct: 1246 ENEQFRQLEDSQLRDRQSQQDLQHLLGEQ--QERDREQERRRWQQRDRH---------FP 1294 Query: 691 EIQALQCRPGHPPEQPWETSQMPESQVKGSRRPKFHARPEDYAVSQPNRDIQEKREASL 749 E + L+ ++ SQ + ++ R K + D + + +QE+ E L Sbjct: 1295 EEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPL 1353 Score = 35.4 bits (80), Expect = 0.46 Identities = 83/376 (22%), Positives = 152/376 (40%), Gaps = 64/376 (17%) Query: 397 ENKQLRRAGCPYQA----DEKVK---RLKVKRAELTGLARRLADRARKLQETNLRAVSAP 449 E +QLRR Q D K + +L+ +R E L+R+ DR +L+E +R Sbjct: 1536 EEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQ-LSRQERDRKFRLEEQKVRRQE-- 1592 Query: 450 IPGESCAGLELCQVFARQRARD-LSEQASAPLAKDKQIEELRQECHLLQARVASGPCSDL 508 + +E Q RQ + L ++ +D+Q+ + R+E Sbjct: 1593 ---QERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREE---------------- 1633 Query: 509 HTGRGGPCTQWLNVRDLDRLQRESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRR 568 Q L+ ++ DR E + ++ R +R+ L+ + E + +E Sbjct: 1634 ---------QQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFRE---EEQLLQEGEE 1681 Query: 569 QMLALERELDQRRRECQELGAQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKTDW 628 Q L + + R E Q+L Q R+ + E QL+ L+ + EE R + + + Sbjct: 1682 QQLRRQERDRKFREEEQQLRRQER--ERKFLQEEQQLRRQELERKFREEEQLRQETEQEQ 1739 Query: 629 VRKVEA-----ENSEVRGHLGRAC---QERDASGLIAEQLLQQAARGQDRQQQLQRDPQK 680 +R+ E E ++R QERD EQL Q+ ++ QQ ++ + Sbjct: 1740 LRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQE----REEQQLRSQESDR 1795 Query: 681 ALCDLHPSWKEIQALQCRP-GHPPEQPWETSQM----PESQVKGSRRPKFHARPEDYAVS 735 + +E + Q RP + WE Q+ E +++ R ++ A E +A Sbjct: 1796 KFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAE-EQFATQ 1854 Query: 736 QPNRDIQEKREASLEE 751 + +R +E++E EE Sbjct: 1855 EKSR--REEQELWQEE 1868 Score = 35.0 bits (79), Expect = 0.60 Identities = 40/157 (25%), Positives = 68/157 (43%), Gaps = 14/157 (8%) Query: 525 LDRLQRESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRRQMLALERELDQRRREC 584 L++ R+ + E L QRQ ++ A E Q +C+ + E +L RRRE Sbjct: 161 LEQRDRQRRDEELWRQRQEWQEREERRAEEE---QLQSCKGHETEEFPDEEQL--RRREL 215 Query: 585 QELGAQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLG 644 EL RR+G E + Q + + EE + + +RK E + E Sbjct: 216 LEL-------RRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQ 268 Query: 645 RACQERDAS--GLIAEQLLQQAARGQDRQQQLQRDPQ 679 R QE + L ++L ++ + +QQ+L+R+ Q Sbjct: 269 RELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQ 305 Score = 34.7 bits (78), Expect = 0.78 Identities = 73/330 (22%), Positives = 130/330 (39%), Gaps = 39/330 (11%) Query: 462 QVFARQRARDLSEQASAPLAKDKQIEELRQECHLLQARVASGPCSDLHTGRGGPCTQWLN 521 Q+ ++R R E+ ++++ + L +E L Q R + Q L Sbjct: 1422 QLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEE----------QLLQ 1471 Query: 522 VRDLDRLQR-ESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRRQMLALERELDQR 580 R+ +L R E R+ L ++QL Q+ + + Q +E R+ L E++L ++ Sbjct: 1472 EREEQQLHRQERDRKFLEEEQQLRRQERDR----KFREQELRSQEPERKFLEEEQQLHRQ 1527 Query: 581 RREC-----------QELGAQAAPARRRGEEAETQLQAALLKNAWLAEENGR-LQAKTDW 628 +R+ QE G Q R R E QL+ + +E R + + Sbjct: 1528 QRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQK 1587 Query: 629 VRKVEAENS------EVRGHLGRAC--QERDASGLIAEQLLQQAARGQDRQQQLQRDPQK 680 VR+ E E ++R G+ QERD EQLLQ+ Q +Q+ R + Sbjct: 1588 VRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLE 1647 Query: 681 ALCDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQVKGSRRPKFHARPEDYAVSQPNRD 740 L +E Q R E+ + E Q++ R + R E+ + + R+ Sbjct: 1648 EEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDR-KFREEEQQLRRQERE 1706 Query: 741 ---IQEKREASLEESPVALGESASVPQVSE 767 +QE+++ +E E + Q +E Sbjct: 1707 RKFLQEEQQLRRQELERKFREEEQLRQETE 1736 Score = 33.5 bits (75), Expect = 1.7 Identities = 89/387 (22%), Positives = 149/387 (38%), Gaps = 54/387 (13%) Query: 385 WVLARRCYTLQAENKQLRRAGCPYQADEKVKRLKVKRAELTGLARRLADRARKLQ-ETNL 443 W R + Q E +Q R +QA+EK +R R L+ R R+L+ E Sbjct: 748 WQEEERAHRQQQEEEQRRDFTWQWQAEEKSER---GRQRLSARPPLREQRERQLRAEERQ 804 Query: 444 RAVSAPIPGESCAGLELCQVFARQRARDLSEQASAPLAKDKQIEELRQECHLLQARVASG 503 + +P E QR R E ++K+++ L +E LQ R + Sbjct: 805 QREQRFLPEEE---------EKEQRRRQRRE-------REKELQFLEEE-EQLQRRERAQ 847 Query: 504 PCSDLHTGRGGPCTQWLNVRDLDRLQRESQREVLRLQRQLMLQQGNGGAWPEAGGQSATC 563 + G Q R + QR Q+ +L+ + ++ A P A Sbjct: 848 QLQEEEDG-----LQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKP------ALQ 896 Query: 564 EEVRRQMLALERELDQRRRECQELGAQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQ 623 E++R++ L+ E ++ +RE +E + R+ EE + Q + L E R Q Sbjct: 897 EQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLRE--EREKRRRQ 954 Query: 624 AKTDWVRKVEAENSEVRGHLG-----RACQERDASGLIAEQLLQQ------AARGQDRQQ 672 + RK + + LG R QER+ E+L Q+ R + R+Q Sbjct: 955 ERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQ 1014 Query: 673 QLQR------DPQKALCDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQVKGSRRPKFH 726 + +R + Q+ L +E + LQ R E+ E Q E Q+ G R + Sbjct: 1015 EWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREE--EELQQEEEQLLGEER-ETR 1071 Query: 727 ARPEDYAVSQPNRDIQEKREASLEESP 753 R E + ++Q++ E L E P Sbjct: 1072 RRQELERQYRKEEELQQEEEQLLREEP 1098 Score = 33.1 bits (74), Expect = 2.3 Identities = 53/217 (24%), Positives = 88/217 (40%), Gaps = 26/217 (11%) Query: 397 ENKQLRRAGCPYQADEKVKRLKVKRAELTGLARRLADRARK-LQETNLRAVSAPIPGESC 455 E +QLRR + + K + + R E R +R RK L+E LR P E Sbjct: 1712 EEQQLRRQ----ELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLR----PEREEQQ 1763 Query: 456 AGLELCQVFARQRARDLSEQASAPLAKDKQIEELRQECHLLQARVASGPCSDLHTGRGGP 515 + R+ + E+ L + + R+E L Q R G+ Sbjct: 1764 LRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGK--- 1820 Query: 516 CTQWLNVRDLDRLQRESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRRQMLALER 575 +W + ++LQ E Q + LR +R + A Q AT E+ RR+ L + Sbjct: 1821 -YRW----EEEQLQLEEQEQRLRQERDRQYR---------AEEQFATQEKSRREEQELWQ 1866 Query: 576 ELDQRRRECQELGAQAAPARRRGEEAETQLQAALLKN 612 E +Q+RR+ +E + RR+ +E + Q +K+ Sbjct: 1867 EEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKS 1903 Score = 31.6 bits (70), Expect = 6.6 Identities = 38/132 (28%), Positives = 64/132 (48%), Gaps = 23/132 (17%) Query: 27 ENQRRELEKLRAELEAERAGWRAERRRFAARE----RQLREEAERERRQLAD---RLRSK 79 E+QR +L K + E E E A R + RE RQL + R+R+ D L + Sbjct: 1217 EDQRSDL-KWQWEPEKENAV-RDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQ 1274 Query: 80 WEAQRSRELRQLQ---------EEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVR 130 E R +E R+ Q E+++RE + E ++ ++ + ++ +QLL ER+ R Sbjct: 1275 QERDREQERRRWQQRDRHFPEEEQLEREEQKEAKR----RDRKSQEEKQLLREERE-EKR 1329 Query: 131 QARELQRQLAEE 142 + +E R+ EE Sbjct: 1330 RRQETDRKFREE 1341 Score = 31.6 bits (70), Expect = 6.6 Identities = 36/158 (22%), Positives = 65/158 (41%), Gaps = 16/158 (10%) Query: 523 RDLDRLQRESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRRQMLALERELDQRR- 581 +D DR RE ++++ R +R ++ Q +E R+ L E++L Q R Sbjct: 1410 QDRDRKFREEEQQLSRQERDRKFREEE---------QQVRRQERERKFLEEEQQLRQERH 1460 Query: 582 ---RECQELGAQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSE 638 RE ++L + + +E + + L + L + + + +R E E Sbjct: 1461 RKFREEEQLLQEREEQQLHRQERDRKF---LEEEQQLRRQERDRKFREQELRSQEPERKF 1517 Query: 639 VRGHLGRACQERDASGLIAEQLLQQAARGQDRQQQLQR 676 + Q+R L EQ L++ RGQ R+Q R Sbjct: 1518 LEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDR 1555 Score = 31.2 bits (69), Expect = 8.6 Identities = 47/159 (29%), Positives = 66/159 (41%), Gaps = 28/159 (17%) Query: 530 RESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRRQMLALERELDQRRRECQELGA 589 R+ +R+ LR +RQ QQ + +++RR+ RE + RRE QE Sbjct: 279 RKLERQELRRERQEEEQQQQ---------RLRREQQLRRKQEEERREQQEERREQQERRE 329 Query: 590 QAAPAR----RRGEEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLGR 645 Q R RR +E + Q L E + + R+ E E E + L R Sbjct: 330 QQEERREQQLRREQEERREQQ--------LRREQEEERREQQLRREQEEERREQQ--LRR 379 Query: 646 ACQERDASGLIAEQLL---QQAARGQD--RQQQLQRDPQ 679 Q R L EQ L QQ R Q R+QQL+R+ Q Sbjct: 380 EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQ 418 >gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sapiens] Length = 1297 Score = 58.2 bits (139), Expect = 7e-08 Identities = 47/130 (36%), Positives = 68/130 (52%), Gaps = 19/130 (14%) Query: 26 LENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRS 85 LE Q+RE E+ + +L AER ++R ++ Q R E++RR+ R + + E +R Sbjct: 373 LEQQQRENEEHKRQLLAER------QKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRH 426 Query: 86 RELRQLQEEMQREREAEIRQLLRWKEAEQRQL----QQLLH---------RERDGVVRQA 132 E + +EE +R E E + R E EQRQL QQLLH R++ RQA Sbjct: 427 YEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQA 486 Query: 133 RELQRQLAEE 142 LQRQL +E Sbjct: 487 ERLQRQLKQE 496 Score = 44.3 bits (103), Expect = 0.001 Identities = 42/135 (31%), Positives = 71/135 (52%), Gaps = 11/135 (8%) Query: 69 RRQLADRLRSKWEAQRSRELRQLQ---EEMQREREAEIRQLLRWKEAEQRQLQQLLHRER 125 R QLA++ RS EA R ++L Q Q EE +R+ AE ++ + ++ ++R+L++ RE+ Sbjct: 356 RLQLANKERS--EALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREK 413 Query: 126 DGVVRQARELQRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQ---LRWQTDGEQA 182 + +Q RE +R E++ R +E R +L+E Q L+ Q EQA Sbjct: 414 ELRKQQEREQRRHYEEQMRREEERRR---AEHEQEYIRRQLEEEQRQLEILQQQLLHEQA 470 Query: 183 ARIRYLQAALEVERQ 197 + Y + LE +RQ Sbjct: 471 LLLEYKRKQLEEQRQ 485 >gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sapiens] Length = 1305 Score = 58.2 bits (139), Expect = 7e-08 Identities = 47/130 (36%), Positives = 68/130 (52%), Gaps = 19/130 (14%) Query: 26 LENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRS 85 LE Q+RE E+ + +L AER ++R ++ Q R E++RR+ R + + E +R Sbjct: 373 LEQQQRENEEHKRQLLAER------QKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRH 426 Query: 86 RELRQLQEEMQREREAEIRQLLRWKEAEQRQL----QQLLH---------RERDGVVRQA 132 E + +EE +R E E + R E EQRQL QQLLH R++ RQA Sbjct: 427 YEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQA 486 Query: 133 RELQRQLAEE 142 LQRQL +E Sbjct: 487 ERLQRQLKQE 496 Score = 44.3 bits (103), Expect = 0.001 Identities = 42/135 (31%), Positives = 71/135 (52%), Gaps = 11/135 (8%) Query: 69 RRQLADRLRSKWEAQRSRELRQLQ---EEMQREREAEIRQLLRWKEAEQRQLQQLLHRER 125 R QLA++ RS EA R ++L Q Q EE +R+ AE ++ + ++ ++R+L++ RE+ Sbjct: 356 RLQLANKERS--EALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREK 413 Query: 126 DGVVRQARELQRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQ---LRWQTDGEQA 182 + +Q RE +R E++ R +E R +L+E Q L+ Q EQA Sbjct: 414 ELRKQQEREQRRHYEEQMRREEERRR---AEHEQEYIRRQLEEEQRQLEILQQQLLHEQA 470 Query: 183 ARIRYLQAALEVERQ 197 + Y + LE +RQ Sbjct: 471 LLLEYKRKQLEEQRQ 485 >gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sapiens] Length = 1352 Score = 58.2 bits (139), Expect = 7e-08 Identities = 47/130 (36%), Positives = 68/130 (52%), Gaps = 19/130 (14%) Query: 26 LENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRS 85 LE Q+RE E+ + +L AER ++R ++ Q R E++RR+ R + + E +R Sbjct: 373 LEQQQRENEEHKRQLLAER------QKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRH 426 Query: 86 RELRQLQEEMQREREAEIRQLLRWKEAEQRQL----QQLLH---------RERDGVVRQA 132 E + +EE +R E E + R E EQRQL QQLLH R++ RQA Sbjct: 427 YEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQA 486 Query: 133 RELQRQLAEE 142 LQRQL +E Sbjct: 487 ERLQRQLKQE 496 Score = 44.3 bits (103), Expect = 0.001 Identities = 42/135 (31%), Positives = 71/135 (52%), Gaps = 11/135 (8%) Query: 69 RRQLADRLRSKWEAQRSRELRQLQ---EEMQREREAEIRQLLRWKEAEQRQLQQLLHRER 125 R QLA++ RS EA R ++L Q Q EE +R+ AE ++ + ++ ++R+L++ RE+ Sbjct: 356 RLQLANKERS--EALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREK 413 Query: 126 DGVVRQARELQRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQ---LRWQTDGEQA 182 + +Q RE +R E++ R +E R +L+E Q L+ Q EQA Sbjct: 414 ELRKQQEREQRRHYEEQMRREEERRR---AEHEQEYIRRQLEEEQRQLEILQQQLLHEQA 470 Query: 183 ARIRYLQAALEVERQ 197 + Y + LE +RQ Sbjct: 471 LLLEYKRKQLEEQRQ 485 Score = 39.3 bits (90), Expect = 0.032 Identities = 38/131 (29%), Positives = 61/131 (46%), Gaps = 12/131 (9%) Query: 27 ENQRRELEKLRAELEAE--RAGWRAERRRFAARERQLREEA----ERERRQL-----ADR 75 E RRE E+ RAE E E R E+R+ ++QL E E +R+QL A+R Sbjct: 429 EQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQAER 488 Query: 76 LRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQAREL 135 L+ + + +R L LQ + Q +R E + L +KE + +E + R R+ Sbjct: 489 LQRQLKQERDY-LVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQS 547 Query: 136 QRQLAEELVNR 146 + ++ NR Sbjct: 548 SPAMPHKVANR 558 >gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sapiens] Length = 1360 Score = 58.2 bits (139), Expect = 7e-08 Identities = 47/130 (36%), Positives = 68/130 (52%), Gaps = 19/130 (14%) Query: 26 LENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRS 85 LE Q+RE E+ + +L AER ++R ++ Q R E++RR+ R + + E +R Sbjct: 373 LEQQQRENEEHKRQLLAER------QKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRH 426 Query: 86 RELRQLQEEMQREREAEIRQLLRWKEAEQRQL----QQLLH---------RERDGVVRQA 132 E + +EE +R E E + R E EQRQL QQLLH R++ RQA Sbjct: 427 YEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQA 486 Query: 133 RELQRQLAEE 142 LQRQL +E Sbjct: 487 ERLQRQLKQE 496 Score = 44.3 bits (103), Expect = 0.001 Identities = 42/135 (31%), Positives = 71/135 (52%), Gaps = 11/135 (8%) Query: 69 RRQLADRLRSKWEAQRSRELRQLQ---EEMQREREAEIRQLLRWKEAEQRQLQQLLHRER 125 R QLA++ RS EA R ++L Q Q EE +R+ AE ++ + ++ ++R+L++ RE+ Sbjct: 356 RLQLANKERS--EALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREK 413 Query: 126 DGVVRQARELQRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQ---LRWQTDGEQA 182 + +Q RE +R E++ R +E R +L+E Q L+ Q EQA Sbjct: 414 ELRKQQEREQRRHYEEQMRREEERRR---AEHEQEYIRRQLEEEQRQLEILQQQLLHEQA 470 Query: 183 ARIRYLQAALEVERQ 197 + Y + LE +RQ Sbjct: 471 LLLEYKRKQLEEQRQ 485 Score = 39.3 bits (90), Expect = 0.032 Identities = 38/131 (29%), Positives = 61/131 (46%), Gaps = 12/131 (9%) Query: 27 ENQRRELEKLRAELEAE--RAGWRAERRRFAARERQLREEA----ERERRQL-----ADR 75 E RRE E+ RAE E E R E+R+ ++QL E E +R+QL A+R Sbjct: 429 EQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQAER 488 Query: 76 LRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQAREL 135 L+ + + +R L LQ + Q +R E + L +KE + +E + R R+ Sbjct: 489 LQRQLKQERDY-LVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQS 547 Query: 136 QRQLAEELVNR 146 + ++ NR Sbjct: 548 SPAMPHKVANR 558 >gi|41152097 DNA segment on chromosome X and Y (unique) 155 expressed sequence isoform 1 [Homo sapiens] Length = 695 Score = 57.4 bits (137), Expect = 1e-07 Identities = 98/363 (26%), Positives = 144/363 (39%), Gaps = 64/363 (17%) Query: 11 ASPKKPGCSSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERR 70 AS KK LE QR E + R E EAE ER+R R+++ EE ERER+ Sbjct: 266 ASIKKRQLERQKLQELEQQREEQK--RREKEAE------ERQRAEERKQKELEELERERK 317 Query: 71 QLADRLRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVR 130 + ++LR + + QR RELR+ Q+++++ +AE EQ+QLQ+ + E ++ Sbjct: 318 R-EEKLRKREQKQRDRELRRNQKKLEK-LQAE----------EQKQLQEKIKLEERKLLL 365 Query: 131 QARELQR-QLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQ 189 R LQ +L EL++R + E + R + QE +L Q A +R ++ Sbjct: 366 AQRNLQSIRLIAELLSRAKAVKLREQEQKEEKLRLQQQEERRRL-------QEAELRRVE 418 Query: 190 AALEVERQLFLKYILAHFRGH---PALSGSPDPQAVH--------SLEEP---LPQTSSG 235 E ER L L+ R LS PD H L +P + QT S Sbjct: 419 E--EKERALGLQRKERELRERLLSILLSKKPDDSHTHDELGVAHADLLQPVLDILQTVSS 476 Query: 236 SCHAPKPACQLGSLDSLSAEVGVRSRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRS 295 C + LG A S DG + S+ AP C Sbjct: 477 GCVSATTLHPLGGQPPAGAP----------KESPAHPEADGAPKSVNGSVAEEAP-CKEV 525 Query: 296 LDSTRSLPKASKSEERPSSPDTSTPGSRRLSPPPSPLPPPPPPSAHRKLSNPRGGEGSES 355 S R +P+ SP+ PG P + P P+ + +S R SE Sbjct: 526 QSSCRVVPE-------DGSPEKRCPGGVLSCIPDNNQQPKGIPACEQNVS--RKDTRSEQ 576 Query: 356 QPC 358 C Sbjct: 577 DKC 579 Score = 33.5 bits (75), Expect = 1.7 Identities = 23/77 (29%), Positives = 43/77 (55%), Gaps = 1/77 (1%) Query: 64 EAERERRQLADRLRSKWEAQRSRELRQLQEEMQREREAEIRQL-LRWKEAEQRQLQQLLH 122 +A ++RQL + + E QR + R+ +E +R+R E +Q L E E+++ ++L Sbjct: 265 DASIKKRQLERQKLQELEQQREEQKRREKEAEERQRAEERKQKELEELERERKREEKLRK 324 Query: 123 RERDGVVRQARELQRQL 139 RE+ R+ R Q++L Sbjct: 325 REQKQRDRELRRNQKKL 341 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.315 0.131 0.393 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 74,488,539 Number of Sequences: 37866 Number of extensions: 4185343 Number of successful extensions: 40939 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 514 Number of HSP's successfully gapped in prelim test: 1231 Number of HSP's that attempted gapping in prelim test: 23358 Number of HSP's gapped (non-prelim): 11852 length of query: 1639 length of database: 18,247,518 effective HSP length: 116 effective length of query: 1523 effective length of database: 13,855,062 effective search space: 21101259426 effective search space used: 21101259426 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (22.0 bits) S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.