Search of human proteins with 153218646

Search of human proteins with 153218646

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|153218646 cytochrome P450, family 11, subfamily A,
polypeptide 1 isoform a precursor [Homo sapiens]
         (521 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|153218646 cytochrome P450, family 11, subfamily A, polypeptid...  1065   0.0  
gi|153218654 cytochrome P450, family 11, subfamily A, polypeptid...   734   0.0  
gi|119829183 cytochrome P450, family 11, subfamily B, polypeptid...   344   1e-94
gi|61743918 cytochrome P450, family 11, subfamily B, polypeptide...   331   9e-91
gi|71067343 cytochrome P450, family 11, subfamily B, polypeptide...   258   7e-69
gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide ...   236   5e-62
gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1 ...   222   6e-58
gi|4503211 cytochrome P450, family 27, subfamily A, polypeptide ...   204   1e-52
gi|193083117 cytochrome P450 family 24 subfamily A polypeptide 1...   177   2e-44
gi|167466231 cytochrome P450, family 27, subfamily C, polypeptid...   170   3e-42
gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide ...   100   3e-21
gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5...   100   3e-21
gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide ...    96   8e-20
gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8...    93   7e-19
gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7...    92   1e-18
gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide ...    92   1e-18
gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide...    91   3e-18
gi|119220562 cytochrome P450, family 4, subfamily F, polypeptide...    89   1e-17
gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide ...    88   2e-17
gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11...    87   4e-17
gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11...    87   4e-17
gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide...    86   1e-16
gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide ...    83   5e-16
gi|158937242 cytochrome P450, family 4, subfamily A, polypeptide...    78   2e-14
gi|189491763 cytochrome P450, family 1, subfamily B, polypeptide...    77   4e-14
gi|195972898 thromboxane A synthase 1, platelet isoform TXS-I [H...    76   7e-14
gi|195972896 thromboxane A synthase 1, platelet isoform TXS-I [H...    76   7e-14
gi|30023836 cytochrome P450 4Z1 [Homo sapiens]                         76   9e-14
gi|29837648 cytochrome P450, family 4, subfamily X, polypeptide ...    75   1e-13
gi|158138530 cytochrome P450, family 4, subfamily F, polypeptide...    75   1e-13

>gi|153218646 cytochrome P450, family 11, subfamily A, polypeptide 1
           isoform a precursor [Homo sapiens]
          Length = 521

 Score = 1065 bits (2754), Expect = 0.0
 Identities = 521/521 (100%), Positives = 521/521 (100%)

Query: 1   MLAKGLPPRSVLVKGCQTFLSAPREGLGRLRVPTGEGAGISTRSPRPFNEIPSPGDNGWL 60
           MLAKGLPPRSVLVKGCQTFLSAPREGLGRLRVPTGEGAGISTRSPRPFNEIPSPGDNGWL
Sbjct: 1   MLAKGLPPRSVLVKGCQTFLSAPREGLGRLRVPTGEGAGISTRSPRPFNEIPSPGDNGWL 60

Query: 61  NLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVIDPEDVALLFKSEGPNPER 120
           NLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVIDPEDVALLFKSEGPNPER
Sbjct: 61  NLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVIDPEDVALLFKSEGPNPER 120

Query: 121 FLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVS 180
           FLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVS
Sbjct: 121 FLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVS 180

Query: 181 VLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQM 240
           VLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQM
Sbjct: 181 VLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQM 240

Query: 241 FHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRG 300
           FHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRG
Sbjct: 241 FHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRG 300

Query: 301 ILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAAR 360
           ILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAAR
Sbjct: 301 ILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAAR 360

Query: 361 HQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIY 420
           HQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIY
Sbjct: 361 HQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIY 420

Query: 421 ALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINML 480
           ALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINML
Sbjct: 421 ALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINML 480

Query: 481 ENFRVEIQHLSDVGTTFNLILMPEKPISFTFWPFNQEATQQ 521
           ENFRVEIQHLSDVGTTFNLILMPEKPISFTFWPFNQEATQQ
Sbjct: 481 ENFRVEIQHLSDVGTTFNLILMPEKPISFTFWPFNQEATQQ 521


>gi|153218654 cytochrome P450, family 11, subfamily A, polypeptide 1
           isoform b [Homo sapiens]
          Length = 363

 Score =  734 bits (1894), Expect = 0.0
 Identities = 363/363 (100%), Positives = 363/363 (100%)

Query: 159 MAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGER 218
           MAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGER
Sbjct: 1   MAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGER 60

Query: 219 QGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKAD 278
           QGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKAD
Sbjct: 61  QGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKAD 120

Query: 279 IYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWH 338
           IYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWH
Sbjct: 121 IYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWH 180

Query: 339 LYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYL 398
           LYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYL
Sbjct: 181 LYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYL 240

Query: 399 VNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWG 458
           VNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWG
Sbjct: 241 VNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWG 300

Query: 459 VRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPISFTFWPFNQEA 518
           VRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPISFTFWPFNQEA
Sbjct: 301 VRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPISFTFWPFNQEA 360

Query: 519 TQQ 521
           TQQ
Sbjct: 361 TQQ 363


>gi|119829183 cytochrome P450, family 11, subfamily B, polypeptide 2
           precursor [Homo sapiens]
          Length = 503

 Score =  344 bits (883), Expect = 1e-94
 Identities = 193/496 (38%), Positives = 281/496 (56%), Gaps = 3/496 (0%)

Query: 20  LSAPREGLGRLRVPTGEGAGISTRSPRPFNEIPSPGDNGWLNLYHFWRETGTHKVHLHHV 79
           ++AP   L R R   G  A  + R+  PF  +P    N WL L   WRE G   +HL   
Sbjct: 11  VAAPWLSLQRARA-LGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQGYEHLHLEMH 69

Query: 80  QNFQKYGPIYREKLGNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGV 139
           Q FQ+ GPI+R  LG    V V+ PEDV  L + +  +P R ++ PWVAY Q+     GV
Sbjct: 70  QTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKCGV 129

Query: 140 LLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDIS 199
            L     W+ +R+ LN +V++P+A + FLP++DAV+RDF   L +++ +   G+ + D+ 
Sbjct: 130 FLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQ 189

Query: 200 DDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFR 259
             +F +  E+    +FGER G++    +  +  F+ A+  MF ++V ++ +P  L R   
Sbjct: 190 PSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWIS 249

Query: 260 TKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKAN 319
            K WK+H  AWD IF   D   Q  Y EL      H  Y GI+  LL  +++S E IKAN
Sbjct: 250 PKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQH--YTGIVAELLLKAELSLEAIKAN 307

Query: 320 VTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKA 379
             E+ AG VDTT+  L   L+E+ARN  VQ +LR E LAA              +PLL+A
Sbjct: 308 SMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRA 367

Query: 380 SIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTR 439
           ++KETLRL+P+ + L+R + +DLVL++Y IPA TLVQV +Y+LGR    F  PE ++P R
Sbjct: 368 ALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQR 427

Query: 440 WLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNL 499
           WL    +   F ++ FG+G+RQCLGRR+AE EM + L ++L++F VE     D+   ++ 
Sbjct: 428 WLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSF 487

Query: 500 ILMPEKPISFTFWPFN 515
           IL P      TF   N
Sbjct: 488 ILRPGTSPLLTFRAIN 503


>gi|61743918 cytochrome P450, family 11, subfamily B, polypeptide 1
           isoform 1 precursor [Homo sapiens]
          Length = 503

 Score =  331 bits (849), Expect = 9e-91
 Identities = 186/481 (38%), Positives = 269/481 (55%), Gaps = 2/481 (0%)

Query: 35  GEGAGISTRSPRPFNEIPSPGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLG 94
           G  A    R+  PF  +P    N WL L   WRE G   +HL   Q FQ+ GPI+R  LG
Sbjct: 25  GTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQGYEDLHLEVHQTFQELGPIFRYDLG 84

Query: 95  NVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVAL 154
               V V+ PEDV  L + +  +P R  + PWVAY Q+     GV L     W+ +R+ L
Sbjct: 85  GAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRL 144

Query: 155 NQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVI 214
           N EV++P A + FLP++DAV+RDF   L +++ +   G+ + D+   +F +  E+    +
Sbjct: 145 NPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLAL 204

Query: 215 FGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIF 274
           FGER G++    +  +  F+ A+  MF ++V ++ +P  L R    K WK+H  AWD IF
Sbjct: 205 FGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIF 264

Query: 275 SKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMT 334
              D   Q  Y EL    S    Y  I+  LL ++++S + IKAN  E+ AG VDTT   
Sbjct: 265 QYGDNCIQKIYQEL--AFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFP 322

Query: 335 LQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTL 394
           L   L+E+ARN  VQ  LR E LAA              +PLL+A++KETLRL+P+ + L
Sbjct: 323 LLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFL 382

Query: 395 QRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLG 454
           +R   +DLVL++Y IPA TLV+V +Y+LGR P  F  PE ++P RWL    +   F ++ 
Sbjct: 383 ERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVP 442

Query: 455 FGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPISFTFWPF 514
           FG+G+RQCLGRR+AE EM + L ++L++ +VE     D+   ++ IL P      TF   
Sbjct: 443 FGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPLLTFRAI 502

Query: 515 N 515
           N
Sbjct: 503 N 503


>gi|71067343 cytochrome P450, family 11, subfamily B, polypeptide 1
           isoform 2 precursor [Homo sapiens]
          Length = 437

 Score =  258 bits (660), Expect = 7e-69
 Identities = 147/391 (37%), Positives = 213/391 (54%), Gaps = 2/391 (0%)

Query: 35  GEGAGISTRSPRPFNEIPSPGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLG 94
           G  A    R+  PF  +P    N WL L   WRE G   +HL   Q FQ+ GPI+R  LG
Sbjct: 25  GTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQGYEDLHLEVHQTFQELGPIFRYDLG 84

Query: 95  NVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVAL 154
               V V+ PEDV  L + +  +P R  + PWVAY Q+     GV L     W+ +R+ L
Sbjct: 85  GAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRL 144

Query: 155 NQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVI 214
           N EV++P A + FLP++DAV+RDF   L +++ +   G+ + D+   +F +  E+    +
Sbjct: 145 NPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLAL 204

Query: 215 FGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIF 274
           FGER G++    +  +  F+ A+  MF ++V ++ +P  L R    K WK+H  AWD IF
Sbjct: 205 FGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIF 264

Query: 275 SKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMT 334
              D   Q  Y EL    S    Y  I+  LL ++++S + IKAN  E+ AG VDTT   
Sbjct: 265 QYGDNCIQKIYQEL--AFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFP 322

Query: 335 LQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTL 394
           L   L+E+ARN  VQ  LR E LAA              +PLL+A++KETLRL+P+ + L
Sbjct: 323 LLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFL 382

Query: 395 QRYLVNDLVLRDYMIPAKTLVQVAIYALGRE 425
           +R   +DLVL++Y IPA  L  + +  L +E
Sbjct: 383 ERVASSDLVLQNYHIPAGVLKHLQVETLTQE 413


>gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide 1
           [Homo sapiens]
          Length = 508

 Score =  236 bits (601), Expect = 5e-62
 Identities = 156/474 (32%), Positives = 237/474 (50%), Gaps = 11/474 (2%)

Query: 46  RPFNEIPSPGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVIDPE 105
           R   +IP P    +L     + + G  ++H   VQ    +GP++    G V +VYV  P 
Sbjct: 35  RSLADIPGPSTPSFLA--ELFCKGGLSRLHELQVQGAAHFGPVWLASFGTVRTVYVAAPA 92

Query: 106 DVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMAPEATK 165
            V  L + EGP PER    PW  + +  QR  G+L  +   W++ R  L   ++ P+A  
Sbjct: 93  LVEELLRQEGPRPERCSFSPWTEHRRCRQRACGLLTAEGEEWQRLRSLLAPLLLRPQAAA 152

Query: 166 NFLPLLDAVSRDFVSVLHR-RIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEE 224
            +   L+ V  D V  L R R +  G      D++ + ++F  E I  V+ G R G LE 
Sbjct: 153 RYAGTLNNVVCDLVRRLRRQRGRGTGPPALVRDVAGEFYKFGLEGIAAVLLGSRLGCLEA 212

Query: 225 VVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNF 284
            V P+ + FI A+  +F +++  + +P  L  L     W      WD +F+ A  + +  
Sbjct: 213 QVPPDTETFIRAVGSVFVSTLLTMAMPHWLRHLV-PGPWGRLCRDWDQMFAFAQRHVERR 271

Query: 285 YWE--LRQKGSVHHDYRG--ILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLY 340
             E  +R  G    D      L   L   ++  + I  NVTE+L  GVDT S TL W LY
Sbjct: 272 EAEAAMRNGGQPEKDLESGAHLTHFLFREELPAQSILGNVTELLLAGVDTVSNTLSWALY 331

Query: 341 EMARNLKVQDMLRAEVLAARHQAQG--DMATMLQLVPLLKASIKETLRLHPISVTLQRYL 398
           E++R+ +VQ  L +E+ AA          AT+L  +PLLKA +KE LRL+P+     R  
Sbjct: 332 ELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLRLYPVVPGNSRVP 391

Query: 399 VNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWG 458
             D+ + DY+IP  TLV +  YA  R+P  F +P +F P RWL +      F +L FG+G
Sbjct: 392 DKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEGPTPHPFASLPFGFG 451

Query: 459 VRQCLGRRIAELEMTIFLINMLENFRVEIQ-HLSDVGTTFNLILMPEKPISFTF 511
            R C+GRR+AELE+ + L  +L +F V+ +   + V      +L+PE+ I+  F
Sbjct: 452 KRSCMGRRLAELELQMALAQILTHFEVQPEPGAAPVRPKTRTVLVPERSINLQF 505


>gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1
           isoform 1 precursor [Homo sapiens]
          Length = 514

 Score =  222 bits (566), Expect = 6e-58
 Identities = 146/466 (31%), Positives = 235/466 (50%), Gaps = 13/466 (2%)

Query: 49  NEIPSPGDNGWL---NLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVIDPE 105
           N    PG   W    +L     + G  K H   V+  +KYG I+R KLG+ ESV++  P 
Sbjct: 54  NAAALPGPTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPC 113

Query: 106 DVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMAPEATK 165
            +  L+++E   P+R  I PW AY  Y +   G+L+ +   W++ R A  +++M P    
Sbjct: 114 LLEALYRTESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVM 173

Query: 166 NFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEV 225
                ++ V  DF+  +     + G   +  D+  +L +++FESI  V++ +R G+L++ 
Sbjct: 174 KLDNKINEVLADFMGRIDELCDERG---HVEDLYSELNKWSFESICLVLYEKRFGLLQKN 230

Query: 226 VNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFY 285
              EA  FI AI  M  T   M+  P +L +   TK W+DH  AWD IF        N  
Sbjct: 231 AGDEAVNFIMAIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNRL 290

Query: 286 WELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARN 345
            +  Q+ S   D+   +Y     +++S +++ A VTE+    V+TT+ +L W LY ++RN
Sbjct: 291 EKYSQQPSA--DFLCDIYH---QNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRN 345

Query: 346 LKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLR 405
            +VQ  L  E+ +   + Q   A  L+ +P LKA +KE++RL P      R L    VL 
Sbjct: 346 PQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLG 405

Query: 406 DYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGR 465
           +Y +P  T++ +    LG     F D   F P RWL + + I  F +L FG G R C+GR
Sbjct: 406 EYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEKEKINPFAHLPFGVGKRMCIGR 465

Query: 466 RIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMP--EKPISF 509
           R+AEL++ + L  ++  + ++      V    +  L+P  E PI+F
Sbjct: 466 RLAELQLHLALCWIVRKYDIQATDNEPVEMLHSGTLVPSRELPIAF 511


>gi|4503211 cytochrome P450, family 27, subfamily A, polypeptide 1
           precursor [Homo sapiens]
          Length = 531

 Score =  204 bits (520), Expect = 1e-52
 Identities = 140/489 (28%), Positives = 233/489 (47%), Gaps = 19/489 (3%)

Query: 35  GEGAGISTRSPRPFNEIPSPGDNGWLNLYHFWRETGTHKVHLHHVQNFQK--YGPIYREK 92
           G G G+  R  R   EIP  G       + F      + + LH +Q   K  YGP++   
Sbjct: 45  GAGPGVRRRQ-RSLEEIPRLGQLR----FFFQLFVQGYALQLHQLQVLYKAKYGPMWMSY 99

Query: 93  LGNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRV 152
           LG    V +     +  + + EG  P R  +  W  +   +    G    +   W + R 
Sbjct: 100 LGPQMHVNLASAPLLEQVMRQEGKYPVRNDMELWKEHRDQHDLTYGPFTTEGHHWYQLRQ 159

Query: 153 ALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITN 212
           ALNQ ++ P     +    + V  DF++ L +   ++ SGN   D++   + FA E+I  
Sbjct: 160 ALNQRLLKPAEAALYTDAFNEVIDDFMTRLDQLRAESASGNQVSDMAQLFYYFALEAICY 219

Query: 213 VIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDV 272
           ++F +R G L+  +  +   F+ +I  MF  S+    LP     +     WK ++  W+ 
Sbjct: 220 ILFEKRIGCLQRSIPEDTVTFVRSIGLMFQNSLYATFLPKWTRPVL--PFWKRYLDGWNA 277

Query: 273 IFSKA----DIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGV 328
           IFS      D   ++   +L+  G       G L+ LL   ++S  +   ++ E+L  GV
Sbjct: 278 IFSFGKKLIDEKLEDMEAQLQAAGPDGIQVSGYLHFLLASGQLSPREAMGSLPELLMAGV 337

Query: 329 DTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLH 388
           DTTS TL W LY ++++ ++Q+ L  EV+      Q         +PLLKA +KETLRL+
Sbjct: 338 DTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQVPQHKDFAHMPLLKAVLKETLRLY 397

Query: 389 PISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNIT 448
           P+  T  R +  ++ +  ++ P  T      Y + R+PT F +PE+F P RWL   +  T
Sbjct: 398 PVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHYVVSRDPTAFSEPESFQPHRWLRNSQPAT 457

Query: 449 -----YFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEI-QHLSDVGTTFNLILM 502
                 F ++ FG+GVR CLGRRIAELEM + L  +++ ++V +     ++ +   ++L+
Sbjct: 458 PRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVVLAPETGELKSVARIVLV 517

Query: 503 PEKPISFTF 511
           P K +   F
Sbjct: 518 PNKKVGLQF 526


>gi|193083117 cytochrome P450 family 24 subfamily A polypeptide 1
           isoform 2 precursor [Homo sapiens]
          Length = 448

 Score =  177 bits (449), Expect = 2e-44
 Identities = 121/396 (30%), Positives = 194/396 (48%), Gaps = 11/396 (2%)

Query: 49  NEIPSPGDNGWL---NLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVIDPE 105
           N    PG   W    +L     + G  K H   V+  +KYG I+R KLG+ ESV++  P 
Sbjct: 54  NAAALPGPTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPC 113

Query: 106 DVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMAPEATK 165
            +  L+++E   P+R  I PW AY  Y +   G+L+ +   W++ R A  +++M P    
Sbjct: 114 LLEALYRTESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVM 173

Query: 166 NFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEV 225
                ++ V  DF+  +     + G   +  D+  +L +++FESI  V++ +R G+L++ 
Sbjct: 174 KLDNKINEVLADFMGRIDELCDERG---HVEDLYSELNKWSFESICLVLYEKRFGLLQKN 230

Query: 226 VNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFY 285
              EA  FI AI  M  T   M+  P +L +   TK W+DH  AWD IF        N  
Sbjct: 231 AGDEAVNFIMAIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNRL 290

Query: 286 WELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARN 345
            +  Q+ S   D+   +Y     +++S +++ A VTE+    V+TT+ +L W LY ++RN
Sbjct: 291 EKYSQQPSA--DFLCDIYH---QNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRN 345

Query: 346 LKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLR 405
            +VQ  L  E+ +   + Q   A  L+ +P LKA +KE++RL P      R L    VL 
Sbjct: 346 PQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLG 405

Query: 406 DYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWL 441
           +Y +P   + +  I A   EP          P+R L
Sbjct: 406 EYALPKGIVRKYDIQATDNEPVEMLHSGTLVPSREL 441


>gi|167466231 cytochrome P450, family 27, subfamily C, polypeptide 1
           [Homo sapiens]
          Length = 372

 Score =  170 bits (430), Expect = 3e-42
 Identities = 112/368 (30%), Positives = 188/368 (51%), Gaps = 8/368 (2%)

Query: 151 RVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESI 210
           R  L Q ++ P+    +   ++ V  D +  ++    +A  G    +++D  F+++ E +
Sbjct: 2   RSVLRQRILKPKDVAIYSGEVNQVIADLIKRIYLLRSQAEDGETVTNVNDLFFKYSMEGV 61

Query: 211 TNVIFGERQGMLEEVVNPEAQRFIDAI---YQMFHTSVPMLNLPPDLFRLFRTKTWKDHV 267
             +++  R G LE  +      +I+A+   + MF TS+    +P  L R F  K W++  
Sbjct: 62  ATILYESRLGCLENSIPQLTVEYIEALELMFSMFKTSMYAGAIPRWL-RPFIPKPWREFC 120

Query: 268 AAWDVIFSKADIYTQNFYWELR-QKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAG 326
            +WD +F  + I+  N   +++ Q         G+L  L     ++ ++I ANVTEML  
Sbjct: 121 RSWDGLFKFSQIHVDNKLRDIQYQMDRGRRVSGGLLTYLFLSQALTLQEIYANVTEMLLA 180

Query: 327 GVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLR 386
           GVDTTS TL W +Y +AR+ +VQ  +  E++    +     A  +  VPL++A +KETLR
Sbjct: 181 GVDTTSFTLSWTVYLLARHPEVQQTVYREIVKNLGERHVPTAADVPKVPLVRALLKETLR 240

Query: 387 LHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKD-- 444
           L P+     R    DLV+  Y+IP  T + +  YA   +   F   + F P RWL K   
Sbjct: 241 LFPVLPGNGRVTQEDLVIGGYLIPKGTQLALCHYATSYQDENFPRAKEFRPERWLRKGDL 300

Query: 445 KNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSD-VGTTFNLILMP 503
             +  F ++ FG GVR C+GRRIAELE+ + +I +L++F ++    ++ V    + +L P
Sbjct: 301 DRVDNFGSIPFGHGVRSCIGRRIAELEIHLVVIQLLQHFEIKTSSQTNAVHAKTHGLLTP 360

Query: 504 EKPISFTF 511
             PI   F
Sbjct: 361 GGPIHVRF 368


>gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide 4
           [Homo sapiens]
          Length = 503

 Score =  100 bits (249), Expect = 3e-21
 Identities = 65/185 (35%), Positives = 102/185 (55%), Gaps = 5/185 (2%)

Query: 327 GVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAAR-HQAQGDMATMLQLVPLLKASIKETL 385
           G +TTS  L + +YE+A +  VQ  L+ E+ A   ++A     T+LQ+   L   + ETL
Sbjct: 306 GYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQM-EYLDMVVNETL 364

Query: 386 RLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDK 445
           RL PI++ L+R    D+ +    IP   +V +  YAL R+P ++ +PE F P R+  K+K
Sbjct: 365 RLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNK 424

Query: 446 -NITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNL--ILM 502
            NI  +    FG G R C+G R A + M + LI +L+NF  +    + +    +L  +L 
Sbjct: 425 DNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQ 484

Query: 503 PEKPI 507
           PEKP+
Sbjct: 485 PEKPV 489


>gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5
           [Homo sapiens]
          Length = 502

 Score =  100 bits (249), Expect = 3e-21
 Identities = 106/452 (23%), Positives = 188/452 (41%), Gaps = 54/452 (11%)

Query: 82  FQKYGPIYREKLGNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQR----PI 137
           ++KYG ++    G +  + + DP+ +  +   E              Y  +  R    P+
Sbjct: 65  YKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKE-------------CYSVFTNRRSLGPV 111

Query: 138 GVL-----LKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSG 192
           G +     L +   WK+ R      +++P  T   L  +  +   +  VL R +++    
Sbjct: 112 GFMKSAISLAEDEEWKRIR-----SLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEK 166

Query: 193 NYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPP 252
                + D    ++ + IT   FG     ++ + NP+   F+++  +          L P
Sbjct: 167 GKPVTLKDIFGAYSMDVITGTSFGVN---IDSLNNPQ-DPFVESTKKFLKFGF----LDP 218

Query: 253 DLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWEL--RQKGSVHHD---YRGILYRLLG 307
               +           A +V     D  T NF  +   R K S  +D   +R    +L+ 
Sbjct: 219 LFLSIILFPFLTPVFEALNVSLFPKD--TINFLSKSVNRMKKSRLNDKQKHRLDFLQLMI 276

Query: 308 DSKMSFE----------DIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVL 357
           DS+ S E          ++ A     +  G +TTS  L + LYE+A +  VQ  L+ E+ 
Sbjct: 277 DSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEID 336

Query: 358 AARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQV 417
           A            +  +  L   + ETLRL P+++ L+R    D+ +    IP  ++V +
Sbjct: 337 AVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVI 396

Query: 418 AIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLI 477
             YAL  +P ++ +PE F P R+  K  +I  +    FG G R C+G R A + M + LI
Sbjct: 397 PTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALI 456

Query: 478 NMLENFRVEIQHLSDVGTTFNL--ILMPEKPI 507
            +L+NF  +    + +    +   +L PEKPI
Sbjct: 457 RVLQNFSFKPCKETQIPLKLDTQGLLQPEKPI 488


>gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 2 [Homo sapiens]
          Length = 503

 Score = 95.9 bits (237), Expect = 8e-20
 Identities = 116/463 (25%), Positives = 195/463 (42%), Gaps = 46/463 (9%)

Query: 70  GTHKVHLHHVQNF-----QKYGPIYREKLGNVESVYVIDPEDVALLFKSEGPNPERFLIP 124
           GT   +L  + NF     +KYG ++    G    + ++DP+ +  +   E  +       
Sbjct: 48  GTILFYLRGLWNFDRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYS------- 100

Query: 125 PWVAYHQYYQRPIGVL-----LKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFV 179
             V  +Q    P+G L       +   WK+ R  L+    + +  K  +P++        
Sbjct: 101 --VFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSPAFTSVKF-KEMVPIISQCG---- 153

Query: 180 SVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQ 239
            +L R +++    + S ++ D    +  + IT  +FG     L    +P  +     +  
Sbjct: 154 DMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKL 213

Query: 240 MF-HTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVI-FSKADIYTQNFYWELRQKGSVHHD 297
            F    + +++L P L  +F  +     +   DV  F K  I       E R K    H 
Sbjct: 214 DFLDPFLLLISLFPFLTPVF--EALNIGLFPKDVTHFLKNSIERMK---ESRLKDKQKH- 267

Query: 298 YRGILYRLLGDSKMSFE----------DIKANVTEMLAGGVDTTSMTLQWHLYEMARNLK 347
            R   ++ + DS+ S E          ++ A    ++    DTTS TL + +YE+A +  
Sbjct: 268 -RVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPD 326

Query: 348 VQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDY 407
           VQ  L+ E+ A            L  +  L   + ETLRL P+   + R    D+ +   
Sbjct: 327 VQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGV 386

Query: 408 MIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDK-NITYFRNLGFGWGVRQCLGRR 466
            IP    V V IYAL  +P ++ +PE F P R+  K+K +I  +R + FG G R C+G R
Sbjct: 387 FIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRNCIGMR 446

Query: 467 IAELEMTIFLINMLENFRVEIQHLSDVGTTF-NL-ILMPEKPI 507
            A   + + +I  L+NF  +    + +     NL IL PEKPI
Sbjct: 447 FALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLPILQPEKPI 489


>gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8
           [Homo sapiens]
          Length = 520

 Score = 92.8 bits (229), Expect = 7e-19
 Identities = 63/185 (34%), Positives = 97/185 (52%), Gaps = 6/185 (3%)

Query: 310 KMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEV---LAARHQAQGD 366
           ++S EDI+A     + GG DTT+  L W LY +AR+ + Q+  R EV   L  R   + +
Sbjct: 312 ELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDREPKEIE 371

Query: 367 MATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRD-YMIPAKTLVQVAIYALGRE 425
              + QL P L   +KE+LRLHP   T  R    D+VL D  +IP   +  + I+A+   
Sbjct: 372 WDDLAQL-PFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVCNINIFAIHHN 430

Query: 426 PTFFFDPENFDPTRWLSKD-KNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFR 484
           P+ + DPE +DP R+  ++ +  +    + F  G R C+G++ A  EM + L   L  FR
Sbjct: 431 PSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKVVLALTLLRFR 490

Query: 485 VEIQH 489
           +   H
Sbjct: 491 ILPDH 495


>gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7
           [Homo sapiens]
          Length = 503

 Score = 92.0 bits (227), Expect = 1e-18
 Identities = 61/197 (30%), Positives = 102/197 (51%), Gaps = 5/197 (2%)

Query: 315 DIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEV-LAARHQAQGDMATMLQL 373
           ++ A     +  G +TTS  L + +YE+A +  VQ  ++ E+     ++A     T+LQL
Sbjct: 294 ELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQL 353

Query: 374 VPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPE 433
              L   + ETLRL P+++ L+R    D+ +    IP   +V +  Y L  +P ++ +PE
Sbjct: 354 -EYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPE 412

Query: 434 NFDPTRWLSKDK-NITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSD 492
            F P R+  K+K NI  +    FG G R C+G R A + M + L+ +L+NF  +    + 
Sbjct: 413 KFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQ 472

Query: 493 V--GTTFNLILMPEKPI 507
           +     F  +L+ EKPI
Sbjct: 473 IPLKLRFGGLLLTEKPI 489


>gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 1 [Homo sapiens]
          Length = 504

 Score = 92.0 bits (227), Expect = 1e-18
 Identities = 116/464 (25%), Positives = 196/464 (42%), Gaps = 47/464 (10%)

Query: 70  GTHKVHLHHVQNF-----QKYGPIYREKLGNVESVYVIDPEDVALLFKSEGPNPERFLIP 124
           GT   +L  + NF     +KYG ++    G    + ++DP+ +  +   E  +       
Sbjct: 48  GTILFYLRGLWNFDRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYS------- 100

Query: 125 PWVAYHQYYQRPIGVL-----LKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFV 179
             V  +Q    P+G L       +   WK+ R  L+    + +  K  +P++        
Sbjct: 101 --VFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSPAFTSVKF-KEMVPIISQCG---- 153

Query: 180 SVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQ 239
            +L R +++    + S ++ D    +  + IT  +FG     L    +P  +     +  
Sbjct: 154 DMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKL 213

Query: 240 MF-HTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVI-FSKADIYTQNFYWELRQKGSVHHD 297
            F    + +++L P L  +F  +     +   DV  F K  I       E R K    H 
Sbjct: 214 DFLDPFLLLISLFPFLTPVF--EALNIGLFPKDVTHFLKNSIERMK---ESRLKDKQKH- 267

Query: 298 YRGILYRLLGDSKMSFE----------DIKANVTEMLAGGVDTTSMTLQWHLYEMARNLK 347
            R   ++ + DS+ S E          ++ A    ++    DTTS TL + +YE+A +  
Sbjct: 268 -RVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPD 326

Query: 348 VQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDY 407
           VQ  L+ E+ A            L  +  L   + ETLRL P+   + R    D+ +   
Sbjct: 327 VQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGV 386

Query: 408 MIPAKTLVQVAIYALGREPTFFFDPENFDP-TRWLSKDK-NITYFRNLGFGWGVRQCLGR 465
            IP    V V IYAL  +P ++ +PE F P +R+  K+K +I  +R + FG G R C+G 
Sbjct: 387 FIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFSKKNKDSIDLYRYIPFGAGPRNCIGM 446

Query: 466 RIAELEMTIFLINMLENFRVEIQHLSDVGTTF-NL-ILMPEKPI 507
           R A   + + +I  L+NF  +    + +     NL IL PEKPI
Sbjct: 447 RFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLPILQPEKPI 490


>gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide 12
           [Homo sapiens]
          Length = 524

 Score = 90.9 bits (224), Expect = 3e-18
 Identities = 69/210 (32%), Positives = 101/210 (48%), Gaps = 7/210 (3%)

Query: 311 MSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEV---LAARHQAQGDM 367
           +S EDI+A     + GG DTT+  L W LY +AR+ + Q+  R EV   L  R   + + 
Sbjct: 313 LSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEW 372

Query: 368 ATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRD-YMIPAKTLVQVAIYALGREP 426
             + QL P L   +KE+LRLHP +  + R    D+VL D  +IP      + I  +   P
Sbjct: 373 DDLAQL-PFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNP 431

Query: 427 TFFFDPENFDPTRW-LSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRV 485
           T + DPE +DP R+     K  +    + F  G R C+G+  A  EM + L  ML +FR 
Sbjct: 432 TVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRF 491

Query: 486 EIQHLSDVGTTFNLILMPEKPISFTFWPFN 515
              H ++      LI+  E  +     P N
Sbjct: 492 LPDH-TEPRRKLELIMRAEGGLWLRVEPLN 520


>gi|119220562 cytochrome P450, family 4, subfamily F, polypeptide 3
           [Homo sapiens]
          Length = 520

 Score = 88.6 bits (218), Expect = 1e-17
 Identities = 63/185 (34%), Positives = 93/185 (50%), Gaps = 6/185 (3%)

Query: 310 KMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEV---LAARHQAQGD 366
           K+S EDI+A     +  G DTT+  L W LY +A++ + Q+  R EV   L  R   + +
Sbjct: 312 KLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIE 371

Query: 367 MATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRD-YMIPAKTLVQVAIYALGRE 425
              + QL P L   IKE+LRLHP    + R    D+VL D  +IP   +  ++++     
Sbjct: 372 WDDLAQL-PFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLISVFGTHHN 430

Query: 426 PTFFFDPENFDPTRWLSKD-KNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFR 484
           P  + DPE +DP R+  K+ K  +    + F  G R C+G+  A  EM + L   L  FR
Sbjct: 431 PAVWPDPEVYDPFRFDPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLGLTLLRFR 490

Query: 485 VEIQH 489
           V   H
Sbjct: 491 VLPDH 495


>gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide 2
           [Homo sapiens]
          Length = 520

 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 60/185 (32%), Positives = 94/185 (50%), Gaps = 6/185 (3%)

Query: 310 KMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEV---LAARHQAQGD 366
           K+S EDI+A     +  G DTT+  L W LY +A++ + Q+  R EV   L  R   + +
Sbjct: 312 KLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIE 371

Query: 367 MATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRD-YMIPAKTLVQVAIYALGRE 425
              +  L P L   +KE+LRLHP    + R++  D+VL D  +IP   +  ++++     
Sbjct: 372 WDDLAHL-PFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHN 430

Query: 426 PTFFFDPENFDPTRWLSKD-KNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFR 484
           P  + DPE +DP R+  ++ K  +    + F  G R C+G+  A  EM + L   L  FR
Sbjct: 431 PAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFR 490

Query: 485 VEIQH 489
           V   H
Sbjct: 491 VLPDH 495


>gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11
           [Homo sapiens]
          Length = 524

 Score = 87.0 bits (214), Expect = 4e-17
 Identities = 99/369 (26%), Positives = 159/369 (43%), Gaps = 25/369 (6%)

Query: 138 GVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKK-AGSGNYSG 196
           G+LL     W + R      ++ P    N L     +    V+++H + ++ A  G+   
Sbjct: 135 GLLLSGGDKWSRHR-----RMLTPAFHFNILKPYMKIFNKSVNIMHDKWQRLASEGSARL 189

Query: 197 DISDDLFRFAFESITNVIFGERQGMLEE-----VVNPEAQRFIDAIYQ--MFHTSVPMLN 249
           D+ + +     +S+   +F       E+         E   F++   Q  + HT   +  
Sbjct: 190 DMFEHISLMTLDSLQKCVFSFESNCQEKPSEYIAAILELSAFVEKRNQQILLHTDF-LYY 248

Query: 250 LPPDLFRLFRTKTWKDHVAAWDVIFSK-ADIYTQNFYWELRQKG-SVHHDYRGILYRLLG 307
           L PD  R FR      H     VI  +   + TQ     L+ K  S   D+  +L     
Sbjct: 249 LTPDGQR-FRRACHLVHDFTDAVIQERRCTLPTQGIDDFLKNKAKSKTLDFIDVLLLSKD 307

Query: 308 DS--KMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEV---LAARHQ 362
           +   ++S EDI+A     +  G DTT+  L W LY +A++ + Q+  R EV   L  R  
Sbjct: 308 EDGKELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREP 367

Query: 363 AQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRD-YMIPAKTLVQVAIYA 421
            + +   + QL P L   IKE+LRLHP    + R    D VL D  +IP   +  + I  
Sbjct: 368 IEIEWDDLAQL-PFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVCLINIIG 426

Query: 422 LGREPTFFFDPENFDPTRWLSKD-KNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINML 480
           +   PT + DPE +DP R+  ++ K  +    + F  G R C+G+  A  EM + L   L
Sbjct: 427 IHYNPTVWPDPEVYDPFRFDQENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTL 486

Query: 481 ENFRVEIQH 489
            +FR+   H
Sbjct: 487 LHFRILPTH 495


>gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11
           [Homo sapiens]
          Length = 524

 Score = 87.0 bits (214), Expect = 4e-17
 Identities = 99/369 (26%), Positives = 159/369 (43%), Gaps = 25/369 (6%)

Query: 138 GVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKK-AGSGNYSG 196
           G+LL     W + R      ++ P    N L     +    V+++H + ++ A  G+   
Sbjct: 135 GLLLSGGDKWSRHR-----RMLTPAFHFNILKPYMKIFNKSVNIMHDKWQRLASEGSARL 189

Query: 197 DISDDLFRFAFESITNVIFGERQGMLEE-----VVNPEAQRFIDAIYQ--MFHTSVPMLN 249
           D+ + +     +S+   +F       E+         E   F++   Q  + HT   +  
Sbjct: 190 DMFEHISLMTLDSLQKCVFSFESNCQEKPSEYIAAILELSAFVEKRNQQILLHTDF-LYY 248

Query: 250 LPPDLFRLFRTKTWKDHVAAWDVIFSK-ADIYTQNFYWELRQKG-SVHHDYRGILYRLLG 307
           L PD  R FR      H     VI  +   + TQ     L+ K  S   D+  +L     
Sbjct: 249 LTPDGQR-FRRACHLVHDFTDAVIQERRCTLPTQGIDDFLKNKAKSKTLDFIDVLLLSKD 307

Query: 308 DS--KMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEV---LAARHQ 362
           +   ++S EDI+A     +  G DTT+  L W LY +A++ + Q+  R EV   L  R  
Sbjct: 308 EDGKELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREP 367

Query: 363 AQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRD-YMIPAKTLVQVAIYA 421
            + +   + QL P L   IKE+LRLHP    + R    D VL D  +IP   +  + I  
Sbjct: 368 IEIEWDDLAQL-PFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVCLINIIG 426

Query: 422 LGREPTFFFDPENFDPTRWLSKD-KNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINML 480
           +   PT + DPE +DP R+  ++ K  +    + F  G R C+G+  A  EM + L   L
Sbjct: 427 IHYNPTVWPDPEVYDPFRFDQENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTL 486

Query: 481 ENFRVEIQH 489
            +FR+   H
Sbjct: 487 LHFRILPTH 495


>gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide 2
           [Homo sapiens]
          Length = 525

 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 104/448 (23%), Positives = 184/448 (41%), Gaps = 43/448 (9%)

Query: 84  KYGPIYREKLGNVESVYVIDPEDVALLFKSEGPNPERFL---IPPWVAYHQYYQRPIGVL 140
           ++ P+ +  +G V  V + + E+V ++  S     +  +   + PW+         +G+L
Sbjct: 85  RHMPLLKLWVGPVPMVALYNAENVEVILTSSKQIDKSSMYKFLEPWLG--------LGLL 136

Query: 141 LKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISD 200
                 W+  R  L          ++FL +++  +   V  L + I +     +      
Sbjct: 137 TSTGNKWRSRRKMLTPTFHFT-ILEDFLDIMNEQANILVKKLEKHINQEAFNCFFY---- 191

Query: 201 DLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLP---PDLFRL 257
            +   A + I     G+  G        +   ++ A+Y+M       + +P    DL+ L
Sbjct: 192 -ITLCALDIICETAMGKNIGAQSN----DDSEYVRAVYRMSEMIFRRIKMPWLWLDLWYL 246

Query: 258 FRTKTWKD-------HVAAWDVIFSKADIYTQNFYWELRQKGSV--HHDYRGILYRLLG- 307
              + W+        H     VI  +A+    N       +GS    +  R  L  LL  
Sbjct: 247 MFKEGWEHKKSLQILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLLSV 306

Query: 308 ----DSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQA 363
                +++S EDI+  V   +  G DTT+  + W LY +  N +VQ  +  E+     ++
Sbjct: 307 TDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKS 366

Query: 364 QGDMATMLQLVPL--LKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYA 421
               AT+  L  L  L+  IKETLRL P      R +  D  +  Y +   T   +  YA
Sbjct: 367 DRP-ATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTEAVIIPYA 425

Query: 422 LGREPTFFFDPENFDPTRWLSKDKNITY-FRNLGFGWGVRQCLGRRIAELEMTIFLINML 480
           L R+P +F +PE F P R+  ++    + +  + F  G R C+G++ A +E    L  +L
Sbjct: 426 LHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCIL 485

Query: 481 ENFRVEI-QHLSDVGTTFNLILMPEKPI 507
            +F +E  Q   ++G    LIL P   I
Sbjct: 486 RHFWIESNQKREELGLEGQLILRPSNGI 513


>gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide 2
           [Homo sapiens]
          Length = 502

 Score = 83.2 bits (204), Expect = 5e-16
 Identities = 106/459 (23%), Positives = 189/459 (41%), Gaps = 49/459 (10%)

Query: 46  RPFNEIPSPGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVIDPE 105
           RP N  P P    +L  +         + HL      +KYG ++  +LG++ +V +    
Sbjct: 39  RPKNYPPGPWRLPFLGNFFL---VDFEQSHLEVQLFVKKYGNLFSLELGDISAVLITG-- 93

Query: 106 DVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMAPEATK 165
            + L+ ++     + F   P     ++  +  G+++    AWK+ R           A +
Sbjct: 94  -LPLIKEALIHMDQNFGNRPVTPMREHIFKKNGLIMSSGQAWKEQRR------FTLTALR 146

Query: 166 NF---LPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVI----FGER 218
           NF      L+   ++    L   IK+      +G   D  F+    +++N+I    FGER
Sbjct: 147 NFGLGKKSLEERIQEEAQHLTEAIKEE-----NGQPFDPHFKIN-NAVSNIICSITFGER 200

Query: 219 -----------QGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHV 267
                        +L+EV   EA +    +Y +F   +  L  P     LF    WK   
Sbjct: 201 FEYQDSWFQQLLKLLDEVTYLEASKTCQ-LYNVFPWIMKFLPGPHQT--LF--SNWKKLK 255

Query: 268 AAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSF--EDIKANVTEMLA 325
                +F    I      W   +       Y   + +  G+   SF  E++  +  ++  
Sbjct: 256 -----LFVSHMIDKHRKDWNPAETRDFIDAYLKEMSKHTGNPTSSFHEENLICSTLDLFF 310

Query: 326 GGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETL 385
            G +TTS TL+W L  MA   ++Q+ ++AE+     Q Q       + +P   A I E  
Sbjct: 311 AGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMPYTNAVIHEVQ 370

Query: 386 RL-HPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKD 444
           R+ + I + + R +  D  L  Y +P  T++   + AL R+PT +  P+ F+P  +L   
Sbjct: 371 RMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLENG 430

Query: 445 KNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF 483
           +       + F  G R CLG ++A  E+ IF  ++++ F
Sbjct: 431 QFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKF 469


>gi|158937242 cytochrome P450, family 4, subfamily A, polypeptide 11
           [Homo sapiens]
          Length = 519

 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 95/402 (23%), Positives = 166/402 (41%), Gaps = 45/402 (11%)

Query: 94  GNVESVYVIDPEDVALLFKSEGPNPE---RFLIPPWVAYHQYYQRPIGVLLKKSAAWKKD 150
           G    V + DP+ + ++     P      RFL P W+ Y        G+LL     W + 
Sbjct: 92  GGKVRVQLYDPDYMKVILGRSDPKSHGSYRFLAP-WIGY--------GLLLLNGQTWFQH 142

Query: 151 RVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESI 210
           R      ++ P    + L     +  D V V+  + ++    +   ++   +     ++I
Sbjct: 143 R-----RMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTI 197

Query: 211 TNVIFGERQGMLEEVVNPEAQRFIDAIYQM----FHTSVPMLNLPPDLFRLFRTKTWKDH 266
               F   QG ++  V+  +Q +I AI  +    F       +    ++ L     W   
Sbjct: 198 MKCAFSH-QGSIQ--VDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHR 254

Query: 267 VAAWDVIFSKADIYTQNFYWELRQKGSV-------HHDYRGILY--RLLGDSKMSFEDIK 317
             A  +     D   Q    +L+++G +       H D+  IL   ++   S +S +D++
Sbjct: 255 --ACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLR 312

Query: 318 ANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATM----LQL 373
           A V   +  G DTT+  + W LY +A + K Q+  R E+    H   GD A++    L  
Sbjct: 313 AEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEI----HSLLGDGASITWNHLDQ 368

Query: 374 VPLLKASIKETLRLHPISVTLQRYLVNDLVLRD-YMIPAKTLVQVAIYALGREPTFFFDP 432
           +P     IKE LRL+P    + R L   +   D   +P   +V ++IY L   P  + +P
Sbjct: 369 MPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNP 428

Query: 433 ENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTI 474
           E FDP R+       ++   L F  G R C+G++ A  E+ +
Sbjct: 429 EVFDPFRFAPGSAQHSH-AFLPFSGGSRNCIGKQFAMNELKV 469


>gi|189491763 cytochrome P450, family 1, subfamily B, polypeptide 1
           [Homo sapiens]
          Length = 543

 Score = 77.0 bits (188), Expect = 4e-14
 Identities = 56/209 (26%), Positives = 103/209 (49%), Gaps = 16/209 (7%)

Query: 307 GDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAE----VLAARHQ 362
           G +++  E++ A +T++     DT S  LQW L    R   VQ  ++AE    V   R  
Sbjct: 311 GGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLP 370

Query: 363 AQGDMATMLQLVPLLKASIKETLRLHP-ISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYA 421
             GD   +    P + A + E +R    + VT+      +  +  Y IP  T+V V  ++
Sbjct: 371 CMGDQPNL----PYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWS 426

Query: 422 LGREPTFFFDPENFDPTRWLSKD----KNITYFRNLGFGWGVRQCLGRRIAELEMTIFLI 477
           +  +P  + +PENFDP R+L KD    K++T  R + F  G R+C+G  ++++++ +F+ 
Sbjct: 427 VNHDPLKWPNPENFDPARFLDKDGLINKDLT-SRVMIFSVGKRRCIGEELSKMQLFLFIS 485

Query: 478 NMLE--NFRVEIQHLSDVGTTFNLILMPE 504
            +    +FR      + +  ++ L + P+
Sbjct: 486 ILAHQCDFRANPNEPAKMNFSYGLTIKPK 514


>gi|195972898 thromboxane A synthase 1, platelet isoform TXS-I [Homo
           sapiens]
          Length = 534

 Score = 76.3 bits (186), Expect = 7e-14
 Identities = 52/179 (29%), Positives = 90/179 (50%), Gaps = 4/179 (2%)

Query: 311 MSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEV--LAARHQAQGDMA 368
           ++ ++I       L  G +  + TL +  Y +A N   Q+ L  EV     +H A  +  
Sbjct: 327 LTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAP-EFC 385

Query: 369 TMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTF 428
           ++ + +P L   I ETLR++P +    R    D  +    IPA  ++++A+ AL  +P  
Sbjct: 386 SLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEH 445

Query: 429 FFDPENFDPTRWLSKDK-NITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVE 486
           +  PE F+P R+ ++ +     F  L FG G R CLG R+  LE+ + L+++L  FR +
Sbjct: 446 WPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQ 504


>gi|195972896 thromboxane A synthase 1, platelet isoform TXS-I [Homo
           sapiens]
          Length = 534

 Score = 76.3 bits (186), Expect = 7e-14
 Identities = 52/179 (29%), Positives = 90/179 (50%), Gaps = 4/179 (2%)

Query: 311 MSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEV--LAARHQAQGDMA 368
           ++ ++I       L  G +  + TL +  Y +A N   Q+ L  EV     +H A  +  
Sbjct: 327 LTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAP-EFC 385

Query: 369 TMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTF 428
           ++ + +P L   I ETLR++P +    R    D  +    IPA  ++++A+ AL  +P  
Sbjct: 386 SLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEH 445

Query: 429 FFDPENFDPTRWLSKDK-NITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVE 486
           +  PE F+P R+ ++ +     F  L FG G R CLG R+  LE+ + L+++L  FR +
Sbjct: 446 WPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQ 504


>gi|30023836 cytochrome P450 4Z1 [Homo sapiens]
          Length = 505

 Score = 75.9 bits (185), Expect = 9e-14
 Identities = 88/405 (21%), Positives = 164/405 (40%), Gaps = 34/405 (8%)

Query: 101 VIDPEDVALLFKSEGPNP--ERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEV 158
           V DP+   +L K + P       ++  WV          G++    + WKK R     ++
Sbjct: 93  VHDPDYAKILLKRQDPKSAVSHKILESWVGR--------GLVTLDGSKWKKHR-----QI 139

Query: 159 MAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGER 218
           + P    + L +   +  + V ++  + ++  + N   ++   +     +SI    F   
Sbjct: 140 VKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNSRLELFQHVSLMTLDSIMKCAFSH- 198

Query: 219 QGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNL---PPDLF-------RLFRTKTWKDHVA 268
           QG ++  ++     ++ A++ +   S   +N      DL        ++F     + H  
Sbjct: 199 QGSIQ--LDSTLDSYLKAVFNLSKISNQRMNNFLHHNDLVFKFSSQGQIFSKFNQELHQF 256

Query: 269 AWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFE--DIKANVTEMLAG 326
              VI  + +        +  QK     D+  IL     ++   F   D++A V   +  
Sbjct: 257 TEKVIQDRKESLKDKLKQDTTQKR--RWDFLDILLSAKSENTKDFSEADLQAEVKTFMFA 314

Query: 327 GVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLR 386
           G DTTS  + W LY +A+  + Q   R E+              L  +P     IKE LR
Sbjct: 315 GHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGSSITWEHLSQMPYTTMCIKECLR 374

Query: 387 LHPISVTLQRYLVNDLVLRD-YMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKD- 444
           L+   V + R L   +   D   +PA   V + I+AL   P F+ DP+ F+P R+  ++ 
Sbjct: 375 LYAPVVNISRLLDKPITFPDGRSLPAGITVFINIWALHHNPYFWEDPQVFNPLRFSRENS 434

Query: 445 KNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQH 489
           + I  +  + F  G+R C+G+  A +E  + +   L  F++   H
Sbjct: 435 EKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLRFKLAPDH 479


>gi|29837648 cytochrome P450, family 4, subfamily X, polypeptide 1
           [Homo sapiens]
          Length = 509

 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 99/457 (21%), Positives = 182/457 (39%), Gaps = 34/457 (7%)

Query: 43  RSPRPFNEIPSPGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVI 102
           R  RPF   P+P  + +L    F ++    K+     +  +KY   +   +G  ++ + I
Sbjct: 41  RDLRPF---PAPPTHWFLGHQKFIQDDNMEKLE----EIIEKYPRAFPFWIGPFQAFFCI 93

Query: 103 -DPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMAP 161
            DP+    L     P  +         Y Q +  P+  L K  AA    +   ++ ++ P
Sbjct: 94  YDPDYAKTLLSRTDPKSQ---------YLQKFSPPL--LGKGLAALDGPKWFQHRRLLTP 142

Query: 162 EATKNFLPL-LDAVSRDFVSVLHRRIKKAGSGNYSGDIS--------DDLFRFAFESITN 212
               N L   ++ ++     +L +  K   + + S ++         D + + AF   TN
Sbjct: 143 GFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIIMKCAFSKETN 202

Query: 213 VIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDV 272
                      + +   ++     +Y + + S  +  L P  +R  +     +     D 
Sbjct: 203 CQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQYT--DT 260

Query: 273 IFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKAN--VTEMLAGGVDT 330
           I  +     Q    +       + D+  I+     +S  SF DI  +  V+  L  G DT
Sbjct: 261 IIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAGHDT 320

Query: 331 TSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPI 390
            + ++ W LY +A N + Q+  R EV              L  +      IKET RL P 
Sbjct: 321 LAASISWILYCLALNPEHQERCREEVRGILGDGSSITWDQLGEMSYTTMCIKETCRLIPA 380

Query: 391 SVTLQRYLVNDLVLRD-YMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITY 449
             ++ R L   L   D   +PA   V ++I+ L   P  + +P+ FDP R+  ++ +  +
Sbjct: 381 VPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRH 440

Query: 450 -FRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRV 485
            +  L F  G R C+G+  A +E+ + +  +L +FRV
Sbjct: 441 PYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRV 477


>gi|158138530 cytochrome P450, family 4, subfamily F, polypeptide 22
           [Homo sapiens]
          Length = 531

 Score = 75.1 bits (183), Expect = 1e-13
 Identities = 89/386 (23%), Positives = 158/386 (40%), Gaps = 30/386 (7%)

Query: 138 GVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGN-YSG 196
           G+LL K   W + R      ++ P    + L     +      ++H + +    G+  S 
Sbjct: 143 GLLLSKGDKWSRHR-----RLLTPAFHFDILKPYMKIFNQSADIMHAKWRHLAEGSAVSL 197

Query: 197 DISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVP-MLNLPPDL- 254
           D+ + +     +S+   +F       E++ +     +I AI ++   SV     L   L 
Sbjct: 198 DMFEHISLMTLDSLQKCVFSYNSNCQEKMSD-----YISAIIELSALSVRRQYRLHHYLD 252

Query: 255 FRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHH---------DYRGILYRL 305
           F  +R+   +    A D++        Q     LRQ+G+            D+  +L   
Sbjct: 253 FIYYRSADGRRFRQACDMVHHFTTEVIQERRRALRQQGAEAWLKAKQGKTLDFIDVLLLA 312

Query: 306 LGDS--KMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLR---AEVLAAR 360
             +   ++S EDI+A     +  G DTTS  + W L+ +A+  + Q+  R    EV+  R
Sbjct: 313 RDEDGKELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGR 372

Query: 361 HQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRD-YMIPAKTLVQVAI 419
              + +   + QL P     IKE+LR +P    + R    D+ L D  +IP   +  V+I
Sbjct: 373 ELEELEWDDLTQL-PFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVSI 431

Query: 420 YALGREPTFFFDPENFDPTRW-LSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLIN 478
           Y     PT + D + ++P R+     +  +    + F  G R C+G+  A  E+ + +  
Sbjct: 432 YGTHHNPTVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVVAL 491

Query: 479 MLENFRVEIQHLSDVGTTFNLILMPE 504
            L  FR+ +     V     LIL  E
Sbjct: 492 TLLRFRLSVDRTRKVRRKPELILRTE 517


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.139    0.428 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,948,938
Number of Sequences: 37866
Number of extensions: 918927
Number of successful extensions: 1862
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 60
Number of HSP's successfully gapped in prelim test: 17
Number of HSP's that attempted gapping in prelim test: 1696
Number of HSP's gapped (non-prelim): 90
length of query: 521
length of database: 18,247,518
effective HSP length: 107
effective length of query: 414
effective length of database: 14,195,856
effective search space: 5877084384
effective search space used: 5877084384
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.