Search of human proteins with 15277342

Search of human proteins with 15277342

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens]
         (261 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens]          510   e-145
gi|40254992 carbonic reductase 4 [Homo sapiens]                       129   3e-30
gi|4758504 hydroxysteroid (17-beta) dehydrogenase 10 isoform 1 [...   124   6e-29
gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo ...   110   2e-24
gi|83715985 hydroxysteroid (17-beta) dehydrogenase 10 isoform 2 ...   109   3e-24
gi|66933014 3-hydroxybutyrate dehydrogenase, type 2 [Homo sapiens]    108   4e-24
gi|4504505 hydroxysteroid (17-beta) dehydrogenase 4 [Homo sapiens]    102   4e-22
gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo...   100   2e-21
gi|7705925 dicarbonyl/L-xylulose reductase [Homo sapiens]             100   2e-21
gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo sapi...    93   2e-19
gi|126723750 dehydrogenase/reductase (SDR family) member 4 like ...    92   5e-19
gi|19923817 peroxisomal trans-2-enoyl-CoA reductase [Homo sapiens]     88   7e-18
gi|4503301 2,4-dienoyl CoA reductase 1 precursor [Homo sapiens]        87   1e-17
gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform ...    86   4e-17
gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens]        77   1e-14
gi|10190704 2,4-dienoyl CoA reductase 2 [Homo sapiens]                 75   8e-14
gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo sap...    72   5e-13
gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens]           70   2e-12
gi|25282469 retinol dehydrogenase 10 [Homo sapiens]                    67   2e-11
gi|224922801 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform...    65   5e-11
gi|209862901 dehydrogenase/reductase (SDR family) member 1 [Homo...    65   5e-11
gi|19923983 dehydrogenase/reductase (SDR family) member 1 [Homo ...    65   5e-11
gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A...    65   8e-11
gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo...    64   1e-10
gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]         63   3e-10
gi|150247226 retinol dehydrogenase 16 [Homo sapiens]                   63   3e-10
gi|126723191 dehydrogenase/reductase (SDR family) member 4 like ...    63   3e-10
gi|223646115 short chain dehydrogenase/reductase family 16C, mem...    59   3e-09
gi|50726952 retinol dehydrogenase 5 (11-cis and 9-cis) [Homo sap...    59   3e-09
gi|10190746 retinol dehydrogenase 14 (all-trans and 9-cis) [Homo...    57   2e-08

>gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens]
          Length = 261

 Score =  510 bits (1313), Expect = e-145
 Identities = 261/261 (100%), Positives = 261/261 (100%)

Query: 1   MASQLQNRLRSALALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGS 60
           MASQLQNRLRSALALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGS
Sbjct: 1   MASQLQNRLRSALALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGS 60

Query: 61  KEGPPRGNHAAFQADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDW 120
           KEGPPRGNHAAFQADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDW
Sbjct: 61  KEGPPRGNHAAFQADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDW 120

Query: 121 DKVIAVNLKGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLT 180
           DKVIAVNLKGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLT
Sbjct: 121 DKVIAVNLKGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLT 180

Query: 181 QTAARELGRHGIRCNSVLPGFIATPMTQKVPQKVVDKITEMIPMGHLGDPEDVADVVAFL 240
           QTAARELGRHGIRCNSVLPGFIATPMTQKVPQKVVDKITEMIPMGHLGDPEDVADVVAFL
Sbjct: 181 QTAARELGRHGIRCNSVLPGFIATPMTQKVPQKVVDKITEMIPMGHLGDPEDVADVVAFL 240

Query: 241 ASEDSGYITGTSVEVTGGLFM 261
           ASEDSGYITGTSVEVTGGLFM
Sbjct: 241 ASEDSGYITGTSVEVTGGLFM 261


>gi|40254992 carbonic reductase 4 [Homo sapiens]
          Length = 237

 Score =  129 bits (324), Expect = 3e-30
 Identities = 85/244 (34%), Positives = 131/244 (53%), Gaps = 17/244 (6%)

Query: 16  VTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGSKEGPPRGNHAAFQAD 75
           V G   GIGRAV+  +A +G  +A             R L G  +  G   G+H AF  D
Sbjct: 7   VFGGSRGIGRAVAQLMARKGYRLAVI----------ARNLEGAKAAAGDLGGDHLAFSCD 56

Query: 76  VSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDWDKVIAVNLKGTFLVT 135
           V++    +   E+++    R  + +V+ AGI +D  L+    +D    +  NL G+ L  
Sbjct: 57  VAKEHDVQNTFEELEKHLGRV-NFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLTC 115

Query: 136 QAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLTQTAARELGRHGIRCN 195
           +AA + ++     GSI+N+ SIVG  GN GQ+ Y+ASK G++G ++  A+E+ R  IR N
Sbjct: 116 KAAMRTMIQQQ-GGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRVN 174

Query: 196 SVLPGFIATPMTQKVPQKVVDKITEMIPMGHLGDPEDVADVVAFLASEDSGYITGTSVEV 255
            V PGF+ T MT+ + +   + + + IP+G  G+  +VA  V FL   +S YITG  + V
Sbjct: 175 VVAPGFVHTDMTKDLKE---EHLKKNIPLGRFGETIEVAHAVVFLL--ESPYITGHVLVV 229

Query: 256 TGGL 259
            GGL
Sbjct: 230 DGGL 233


>gi|4758504 hydroxysteroid (17-beta) dehydrogenase 10 isoform 1
           [Homo sapiens]
          Length = 261

 Score =  124 bits (312), Expect = 6e-29
 Identities = 83/266 (31%), Positives = 134/266 (50%), Gaps = 27/266 (10%)

Query: 9   LRSALALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGSKEGPPRGN 68
           ++  +A++TG  SG+G A + RL G+GA+    DL  +  +   + LG           N
Sbjct: 8   VKGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLG-----------N 56

Query: 69  HAAFQ-ADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSE------DDWD 121
           +  F  ADV+  +  +  L   +  F R   V V+CAGI       ++ +      +D+ 
Sbjct: 57  NCVFAPADVTSEKDVQTALALAKGKFGRV-DVAVNCAGIAVASKTYNLKKGQTHTLEDFQ 115

Query: 122 KVIAVNLKGTFLVTQAAAQALVSN-----GCRGSIINISSIVGKVGNVGQTNYAASKAGV 176
           +V+ VNL GTF V +  A  +  N     G RG IIN +S+    G VGQ  Y+ASK G+
Sbjct: 116 RVLDVNLMGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGI 175

Query: 177 IGLTQTAARELGRHGIRCNSVLPGFIATPMTQKVPQKVVDKITEMIPM-GHLGDPEDVAD 235
           +G+T   AR+L   GIR  ++ PG   TP+   +P+KV + +   +P    LGDP + A 
Sbjct: 176 VGMTLPIARDLAPIGIRVMTIAPGLFGTPLLTSLPEKVCNFLASQVPFPSRLGDPAEYAH 235

Query: 236 VVAFLASEDSGYITGTSVEVTGGLFM 261
           +V   A  ++ ++ G  + + G + M
Sbjct: 236 LVQ--AIIENPFLNGEVIRLDGAIRM 259


>gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo
           sapiens]
          Length = 278

 Score =  110 bits (274), Expect = 2e-24
 Identities = 78/252 (30%), Positives = 124/252 (49%), Gaps = 10/252 (3%)

Query: 9   LRSALALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGSKEGPPRGN 68
           L + +ALVT +  GIG A++ RLA +GA V      +    + V  L G G         
Sbjct: 30  LANKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQGEGLSV------ 83

Query: 69  HAAFQADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDWDKVIAVNL 128
                  V +A     L+            +V + A       ++ ++E+ WDK + +N+
Sbjct: 84  -TGTVCHVGKAEDRERLVATAVKLHGGIDILVSNAAVNPFFGSIMDVTEEVWDKTLDINV 142

Query: 129 KGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLTQTAARELG 188
           K   L+T+A    +   G  GS++ +SSI     + G + Y  SK  ++GLT+T A EL 
Sbjct: 143 KAPALMTKAVVPEMEKRG-GGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIELA 201

Query: 189 RHGIRCNSVLPGFIATPMTQKV--PQKVVDKITEMIPMGHLGDPEDVADVVAFLASEDSG 246
              IR N + PG I T  ++ +   ++  + + E + +  LG+PED A +V+FL SED+ 
Sbjct: 202 PRNIRVNCLAPGLIKTSFSRMLWMDKEKEESMKETLRIRRLGEPEDCAGIVSFLCSEDAS 261

Query: 247 YITGTSVEVTGG 258
           YITG +V V GG
Sbjct: 262 YITGETVVVGGG 273


>gi|83715985 hydroxysteroid (17-beta) dehydrogenase 10 isoform 2
           [Homo sapiens]
          Length = 252

 Score =  109 bits (272), Expect = 3e-24
 Identities = 79/266 (29%), Positives = 129/266 (48%), Gaps = 36/266 (13%)

Query: 9   LRSALALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGSKEGPPRGN 68
           ++  +A++TG  SG+G A + RL G+GA+    DL  +  +   + LG           N
Sbjct: 8   VKGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLG-----------N 56

Query: 69  HAAFQ-ADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSE------DDWD 121
           +  F  ADV+  +  +  L   +  F R   V V+CAGI       ++ +      +D+ 
Sbjct: 57  NCVFAPADVTSEKDVQTALALAKGKFGRV-DVAVNCAGIAVASKTYNLKKGQTHTLEDFQ 115

Query: 122 KVIAVNLKGTFLVTQAAAQALVSN-----GCRGSIINISSIVGKVGNVGQTNYAASKAGV 176
           +V+ VNL GTF V +  A  +  N     G RG IIN +S+    G VGQ  Y+ASK G+
Sbjct: 116 RVLDVNLMGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGI 175

Query: 177 IGLTQTAARELGRHGIRCNSVLPGFIATPMTQKVPQKVVDKITEMIPM-GHLGDPEDVAD 235
           +G+T   AR+L   G+           TP+   +P+KV + +   +P    LGDP + A 
Sbjct: 176 VGMTLPIARDLAPIGL---------FGTPLLTSLPEKVCNFLASQVPFPSRLGDPAEYAH 226

Query: 236 VVAFLASEDSGYITGTSVEVTGGLFM 261
           +V   A  ++ ++ G  + + G + M
Sbjct: 227 LVQ--AIIENPFLNGEVIRLDGAIRM 250


>gi|66933014 3-hydroxybutyrate dehydrogenase, type 2 [Homo sapiens]
          Length = 245

 Score =  108 bits (271), Expect = 4e-24
 Identities = 76/258 (29%), Positives = 129/258 (50%), Gaps = 25/258 (9%)

Query: 8   RLRSALALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGSKEGPPRG 67
           RL   + ++T A  GIG+A ++  A EGA V A D++ +  QE  +    PG +      
Sbjct: 3   RLDGKVIILTAAAQGIGQAAALAFAREGAKVIATDINESKLQELEKY---PGIQTRV--- 56

Query: 68  NHAAFQADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDWDKVIAVN 127
                  DV++ +       +V+        V+ + AG      +L   E DWD  + +N
Sbjct: 57  ------LDVTKKKQIDQFANEVERL-----DVLFNVAGFVHHGTVLDCEEKDWDFSMNLN 105

Query: 128 LKGTFLVTQAAAQALVSNGCRGSIINISSIVGKV-GNVGQTNYAASKAGVIGLTQTAARE 186
           ++  +L+ +A    +++    G+IIN+SS+   V G V +  Y+ +KA VIGLT++ A +
Sbjct: 106 VRSMYLMIKAFLPKMLAQKS-GNIINMSSVASSVKGVVNRCVYSTTKAAVIGLTKSVAAD 164

Query: 187 LGRHGIRCNSVLPGFIATPMTQK------VPQKVVDKITEMIPMGHLGDPEDVADVVAFL 240
             + GIRCN V PG + TP  Q+       P++  +   +    G     E++A +  +L
Sbjct: 165 FIQQGIRCNCVCPGTVDTPSLQERIQARGNPEEARNDFLKRQKTGRFATAEEIAMLCVYL 224

Query: 241 ASEDSGYITGTSVEVTGG 258
           AS++S Y+TG  V + GG
Sbjct: 225 ASDESAYVTGNPVIIDGG 242


>gi|4504505 hydroxysteroid (17-beta) dehydrogenase 4 [Homo sapiens]
          Length = 736

 Score =  102 bits (253), Expect = 4e-22
 Identities = 86/263 (32%), Positives = 124/263 (47%), Gaps = 41/263 (15%)

Query: 8   RLRSALALVTGAGSGIGRAVSVRLAGEGATVAACDLD---------RAAAQETVRLLGGP 58
           R    + LVTGAG+G+GRA ++  A  GA V   DL            AA + V  +   
Sbjct: 6   RFDGRVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSLAADKVVEEIRRR 65

Query: 59  GSKEGPPRGNHAAFQADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSED 118
           G K            A+         +++     F R   VVV+ AGI +D     +S++
Sbjct: 66  GGKA----------VANYDSVEEGEKVVKTALDAFGRI-DVVVNNAGILRDRSFARISDE 114

Query: 119 DWDKVIAVNLKGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIG 178
           DWD +  V+L+G+F VT+AA + +      G II  SS  G  GN GQ NY+A+K G++G
Sbjct: 115 DWDIIHRVHLRGSFQVTRAAWEHMKKQKY-GRIIMTSSASGIYGNFGQANYSAAKLGLLG 173

Query: 179 LTQTAARELGRHGIRCNSVLPGFIATPMTQKV-PQKVVDKITEMIPMGHLGDPEDVADVV 237
           L  + A E  +  I CN++ P    + MTQ V P+ +V+ +           PE VA +V
Sbjct: 174 LANSLAIEGRKSNIHCNTIAPN-AGSRMTQTVMPEDLVEAL----------KPEYVAPLV 222

Query: 238 AFLASEDSGYITGTSVEVTGGLF 260
            +L  E        S E  GGLF
Sbjct: 223 LWLCHE--------SCEENGGLF 237


>gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo
           sapiens]
          Length = 270

 Score =  100 bits (248), Expect = 2e-21
 Identities = 71/257 (27%), Positives = 118/257 (45%), Gaps = 20/257 (7%)

Query: 8   RLRSALALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGSKEGPPRG 67
           R    + +VTG G GIG  +       GA V  CD D +  +   + L G          
Sbjct: 6   RYAGKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQELPGA--------- 56

Query: 68  NHAAFQADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDWDKVIAVN 127
                  DV++    + L+ +    F R   VV +       +     S   + +++ +N
Sbjct: 57  --VFILCDVTQEDDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELN 114

Query: 128 LKGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLTQTAAREL 187
           L GT+ +T+ A   L  +  +G++INISS+VG +G      Y A+K  V  +T+  A + 
Sbjct: 115 LLGTYTLTKLALPYLRKS--QGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDE 172

Query: 188 GRHGIRCNSVLPGFIATPMTQKV------PQKVVDKITEMIPMGHLGDPEDVADVVAFLA 241
             +G+R N + PG I TP+ +++      P+  + +     P+G +G P +V     FLA
Sbjct: 173 SPYGVRVNCISPGNIWTPLWEELAALMPDPRATIREGMLAQPLGRMGQPAEVGAAAVFLA 232

Query: 242 SEDSGYITGTSVEVTGG 258
           SE + + TG  + VTGG
Sbjct: 233 SE-ANFCTGIELLVTGG 248


>gi|7705925 dicarbonyl/L-xylulose reductase [Homo sapiens]
          Length = 244

 Score =  100 bits (248), Expect = 2e-21
 Identities = 76/249 (30%), Positives = 117/249 (46%), Gaps = 20/249 (8%)

Query: 15  LVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGSKEGPPRGNHAAFQA 74
           LVTGAG GIGR     L   GA V A    +A     VR    PG +             
Sbjct: 11  LVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVREC--PGIEP---------VCV 59

Query: 75  DVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDWDKVIAVNLKGTFLV 134
           D+ +  A    L  V      P  ++V+ A +   +  L ++++ +D+   VNL+    V
Sbjct: 60  DLGDWEATERALGSVG-----PVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQV 114

Query: 135 TQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLTQTAARELGRHGIRC 194
           +Q  A+ L++ G  G+I+N+SS   +      + Y ++K  +  LT+  A ELG H IR 
Sbjct: 115 SQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRV 174

Query: 195 NSVLPGFIATPMTQKV---PQKVVDKITEMIPMGHLGDPEDVADVVAFLASEDSGYITGT 251
           N+V P  + T M Q     P K    +   IP+G   + E V + + FL S+ SG  TG+
Sbjct: 175 NAVNPTVVMTSMGQATWSDPHKAKTMLNR-IPLGKFAEVEHVVNAILFLLSDRSGMTTGS 233

Query: 252 SVEVTGGLF 260
           ++ V GG +
Sbjct: 234 TLPVEGGFW 242


>gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo
           sapiens]
          Length = 280

 Score = 93.2 bits (230), Expect = 2e-19
 Identities = 74/251 (29%), Positives = 114/251 (45%), Gaps = 11/251 (4%)

Query: 9   LRSALALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGSKEGPPRGN 68
           L + +A+VTG+ SGIG A++ RLA +GA V      +      +  L G G         
Sbjct: 34  LANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLSV------ 87

Query: 69  HAAFQADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDWDKVIAVNL 128
            A     V +A     L+ +          +V S          L  SE  WDK+++VN+
Sbjct: 88  -AGIVCHVGKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNV 146

Query: 129 KGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLTQTAARELG 188
           K   L+       + +   RG++I +SSI      V    Y  SK  ++GLT+T A EL 
Sbjct: 147 KSPALLLSQLLPYMENR--RGAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALELA 204

Query: 189 RHGIRCNSVLPGFIATPMTQKV--PQKVVDKITEMIPMGHLGDPEDVADVVAFLASEDSG 246
              IR N V+PG I T  ++     + +     E   +  +G+ ED A +V+FL S D+ 
Sbjct: 205 PKDIRVNCVVPGIIKTDFSKVFHGNESLWKNFKEHHQLQRIGESEDCAGIVSFLCSPDAS 264

Query: 247 YITGTSVEVTG 257
           Y+ G ++ V G
Sbjct: 265 YVNGENIAVAG 275


>gi|126723750 dehydrogenase/reductase (SDR family) member 4 like 1
           [Homo sapiens]
          Length = 281

 Score = 92.0 bits (227), Expect = 5e-19
 Identities = 79/253 (31%), Positives = 120/253 (47%), Gaps = 9/253 (3%)

Query: 9   LRSALALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPG-SKEGPPRG 67
           L + +ALVT +   IG AV+ RLA +GA V      +    + V  L G G S  G    
Sbjct: 30  LTNKVALVTASTDWIGFAVAQRLAQDGAHVVVSRRKQQNVDQAVATLQGEGLSMTGTV-- 87

Query: 68  NHAAFQADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDWDKVIAVN 127
            H     D     A    L  V    S   S+  S  G+     LL  +E+ WD+ + +N
Sbjct: 88  CHVGKMKDWERLVATAMKLHGVIDILSL--SITNSKRGLFWFT-LLQTAEEAWDRNLDIN 144

Query: 128 LKGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLTQTAAREL 187
            K   L+ +A    +   G  GS+  ++S+       G + Y  SK  ++GL +T A EL
Sbjct: 145 GKALALMIKAVVPEMEKRG-GGSVGFLASVAAFRPLPGFSPYNVSKTALLGLNKTLAIEL 203

Query: 188 GRHGIRCNSVLPGFIATPMTQK--VPQKVVDKITEMIPMGHLGDPEDVADVVAFLASEDS 245
               IR N + PG I T  ++   + ++  + + E + +  LG+PED   +V+FL SED+
Sbjct: 204 APRNIRVNCLAPGLIKTSFSRMLWMDKEKEESMKETLRIRRLGEPEDSLGIVSFLCSEDA 263

Query: 246 GYITGTSVEVTGG 258
            Y+TG +V V GG
Sbjct: 264 SYLTGETVMVGGG 276


>gi|19923817 peroxisomal trans-2-enoyl-CoA reductase [Homo sapiens]
          Length = 303

 Score = 88.2 bits (217), Expect = 7e-18
 Identities = 77/259 (29%), Positives = 118/259 (45%), Gaps = 19/259 (7%)

Query: 9   LRSALALVTGAGSGIGRAVSVRLA--GEGATVAACDLDRAAAQETVRLLGGPGSKEGPPR 66
           L+  +A+VTG  +GIG+A+   L   G    +A+  L+R  +         P +K+    
Sbjct: 16  LQGQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAADELQANLPPTKQA--- 72

Query: 67  GNHAAFQADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLL---HMSEDDWDKV 123
                 Q ++        L++     F +   +V +  G    +FL    H+S   W  V
Sbjct: 73  -RVIPIQCNIRNEEEVNNLVKSTLDTFGKINFLVNNGGG----QFLSPAEHISSKGWHAV 127

Query: 124 IAVNLKGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLTQTA 183
           +  NL GTF + +A   + +     GSI+NI  +  K G     +  A++AGV  LT++ 
Sbjct: 128 LETNLTGTFYMCKAVYSSWMKEH-GGSIVNII-VPTKAGFPLAVHSGAARAGVYNLTKSL 185

Query: 184 ARELGRHGIRCNSVLPGFI----ATPMTQKVPQKVVDKITEMIPMGHLGDPEDVADVVAF 239
           A E    GIR N V PG I    A        Q   +   + IP   +G PE+V+ VV F
Sbjct: 186 ALEWACSGIRINCVAPGVIYSQTAVENYGSWGQSFFEGSFQKIPAKRIGVPEEVSSVVCF 245

Query: 240 LASEDSGYITGTSVEVTGG 258
           L S  + +ITG SV+V GG
Sbjct: 246 LLSPAASFITGQSVDVDGG 264


>gi|4503301 2,4-dienoyl CoA reductase 1 precursor [Homo sapiens]
          Length = 335

 Score = 87.0 bits (214), Expect = 1e-17
 Identities = 67/258 (25%), Positives = 123/258 (47%), Gaps = 16/258 (6%)

Query: 7   NRLRSALALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGSKEGPPR 66
           N  +  +A +TG G+G+G+ ++  L+  GA           A   + +L     +     
Sbjct: 55  NSFQGKVAFITGGGTGLGKGMTTLLSSLGAQCVI-------ASRKMDVLKATAEQISSQT 107

Query: 67  GNHA-AFQADVSEARAARCLLEQVQACFSRPPSVVVSCAG--ITQDEFLLHMSEDDWDKV 123
           GN   A Q DV +    +  + ++      P  V+ + AG  I+  E    +S + W  +
Sbjct: 108 GNKVHAIQCDVRDPDMVQNTVSELIKVAGHPNIVINNAAGNFISPTE---RLSPNAWKTI 164

Query: 124 IAVNLKGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLTQTA 183
             + L GT  VT    + L+      + ++I++I  + G+      A++KAGV  ++++ 
Sbjct: 165 TDIVLNGTAFVTLEIGKQLIKAQKGAAFLSITTIYAETGSGFVVPSASAKAGVEAMSKSL 224

Query: 184 ARELGRHGIRCNSVLPGFIAT--PMTQKVPQKVVDK-ITEMIPMGHLGDPEDVADVVAFL 240
           A E G++G+R N + PG I T    ++  P    +K +   IP G LG  E++A++ AFL
Sbjct: 225 AAEWGKYGMRFNVIQPGPIKTKGAFSRLDPTGTFEKEMIGRIPCGRLGTVEELANLAAFL 284

Query: 241 ASEDSGYITGTSVEVTGG 258
            S+ + +I G  ++  GG
Sbjct: 285 CSDYASWINGAVIKFDGG 302


>gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 1
           [Homo sapiens]
          Length = 266

 Score = 85.5 bits (210), Expect = 4e-17
 Identities = 75/258 (29%), Positives = 127/258 (49%), Gaps = 32/258 (12%)

Query: 13  LALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGSKEGPPRGNHAAF 72
           +ALVTGA  GIGRA +  L  +GA VA  D +  A  +    L     ++  P+      
Sbjct: 7   VALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAAL----DEQFEPQKT-LFI 61

Query: 73  QADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDWDKVIAVNL---- 128
           Q DV++ +  R    +V   F R   ++V+ AG+         +E +W+K + +NL    
Sbjct: 62  QCDVADQQQLRDTFRKVVDHFGRL-DILVNNAGVN--------NEKNWEKTLQINLVSVI 112

Query: 129 KGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLTQTA--ARE 186
            GT+L     ++   + G  G IIN+SS+ G +    Q  Y ASK G++G T++A  A  
Sbjct: 113 SGTYLGLDYMSKQ--NGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAAN 170

Query: 187 LGRHGIRCNSVLPGFIATPMTQKVPQ--------KVVDKITEMIPMGHLGDPEDVADVVA 238
           L   G+R N++ PGF+ T + + + +        +  D I +MI    + DP  +A+ + 
Sbjct: 171 LMNSGVRLNAICPGFVNTAILESIEKEENMGQYIEYKDHIKDMIKYYGILDPPLIANGLI 230

Query: 239 FLASEDSGYITGTSVEVT 256
            L  +D+  + G  +++T
Sbjct: 231 TLIEDDA--LNGAIMKIT 246


>gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens]
          Length = 260

 Score = 77.4 bits (189), Expect = 1e-14
 Identities = 72/247 (29%), Positives = 111/247 (44%), Gaps = 11/247 (4%)

Query: 1   MASQLQNRLRSALALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGS 60
           MA     R R  LALVTGA  GIG AV+  L  +G  V  C    A     +  L     
Sbjct: 1   MARPGMERWRDRLALVTGASGGIGAAVARALVQQGLKVVGC----ARTVGNIEELAAECK 56

Query: 61  KEGPPRGNHAAFQADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDW 120
             G P G    ++ D+S       +   +++  S    + ++ AG+ + + LL  S   W
Sbjct: 57  SAGYP-GTLIPYRCDLSNEEDILSMFSAIRSQHS-GVDICINNAGLARPDTLLSGSTSGW 114

Query: 121 DKVIAVNLKGTFLVTQAAAQALVS-NGCRGSIINISSIVG-KVGNVGQTN-YAASKAGVI 177
             +  VN+    + T+ A Q++   N   G IINI+S+ G +V  +  T+ Y+A+K  V 
Sbjct: 115 KDMFNVNVLALSICTREAYQSMKERNVDDGHIININSMSGHRVLPLSVTHFYSATKYAVT 174

Query: 178 GLTQTAAREL--GRHGIRCNSVLPGFIATPMTQKVPQKVVDKITEMIPMGHLGDPEDVAD 235
            LT+   +EL   +  IR   + PG + T    K+  K  +K            PEDVA+
Sbjct: 175 ALTEGLRQELREAQTHIRATCISPGVVETQFAFKLHDKDPEKAAATYEQMKCLKPEDVAE 234

Query: 236 VVAFLAS 242
            V ++ S
Sbjct: 235 AVIYVLS 241


>gi|10190704 2,4-dienoyl CoA reductase 2 [Homo sapiens]
          Length = 292

 Score = 74.7 bits (182), Expect = 8e-14
 Identities = 68/259 (26%), Positives = 114/259 (44%), Gaps = 17/259 (6%)

Query: 9   LRSALALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGSKEGPPRGN 68
           LR  +A +TG GSGIG  ++      G                 R L G   +   P   
Sbjct: 26  LRDKVAFITGGGSGIGFRIAEIFMRHGCHTVIASRSLPRVLTAARKLAGATGRRCLP--- 82

Query: 69  HAAFQADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLH---MSEDDWDKVIA 125
                 DV    A    ++Q    F R   ++++CA      FL     +S + +  V+ 
Sbjct: 83  ---LSMDVRAPPAVMAAVDQALKEFGRI-DILINCAA---GNFLCPAGALSFNAFKTVMD 135

Query: 126 VNLKGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLTQTAAR 185
           ++  GTF V++   +    +   G I+NI++ +G  G   Q +  ++KA V  +T+  A 
Sbjct: 136 IDTSGTFNVSRVLYEKFFRDH-GGVIVNITATLGNRGQALQVHAGSAKAAVDAMTRHLAV 194

Query: 186 ELGRHGIRCNSVLPGFIA-TPMTQKV--PQKVVDKITEMIPMGHLGDPEDVADVVAFLAS 242
           E G   IR NS+ PG I+ T   +++  PQ  +       P+  LG+  ++A  V +LAS
Sbjct: 195 EWGPQNIRVNSLAPGPISGTEGLRRLGGPQASLSTKVTASPLQRLGNKTEIAHSVLYLAS 254

Query: 243 EDSGYITGTSVEVTGGLFM 261
             + Y+TG  +   GG ++
Sbjct: 255 PLASYVTGAVLVADGGAWL 273


>gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo
           sapiens]
          Length = 300

 Score = 72.0 bits (175), Expect = 5e-13
 Identities = 61/202 (30%), Positives = 90/202 (44%), Gaps = 9/202 (4%)

Query: 9   LRSALALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGSKEGPPRGN 68
           L + +A+VTG+ SGIG A++ RLA +GA V      +      +  L G G         
Sbjct: 34  LANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLSV------ 87

Query: 69  HAAFQADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDWDKVIAVNL 128
            A     V +A     L+ +          +V S          L  SE  WDK+++VN+
Sbjct: 88  -AGIVCHVGKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNV 146

Query: 129 KGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLTQTAARELG 188
           K   L+       + +   RG++I +SSI      V    Y  SK  ++GLT+T A EL 
Sbjct: 147 KSPALLLSQLLPYMENR--RGAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALELA 204

Query: 189 RHGIRCNSVLPGFIATPMTQKV 210
              IR N V+PG I T  ++ V
Sbjct: 205 PKDIRVNCVVPGIIKTDFSKVV 226


>gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens]
          Length = 309

 Score = 69.7 bits (169), Expect = 2e-12
 Identities = 60/225 (26%), Positives = 104/225 (46%), Gaps = 23/225 (10%)

Query: 13  LALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGSKEGPPRGNHAAF 72
           + L+TGAGSG+GR ++++ A  G+ +   D+++   +ET ++     ++E      H A+
Sbjct: 42  IVLITGAGSGLGRLLALQFARLGSVLVLWDINKEGNEETCKM-----AREAGATRVH-AY 95

Query: 73  QADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDWDKVIAVNLKGTF 132
             D S+      + +QV+       S++++ AGI   +  L   ++  +K   VN K   
Sbjct: 96  TCDCSQKEGVYRVADQVKKEVG-DVSILINNAGIVTGKKFLDCPDELMEKSFDVNFKAHL 154

Query: 133 LVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLTQTAAREL---GR 189
              +A   A+++N   G ++ ISS  G  G  G  +Y ASK    G  ++   E     +
Sbjct: 155 WTYKAFLPAMIAND-HGHLVCISSSAGLSGVNGLADYCASKFAAFGFAESVFVETFVQKQ 213

Query: 190 HGIRCNSVLPGFIATPMTQKV------------PQKVVDKITEMI 222
            GI+   V P FI T M +              P+  V+KI E I
Sbjct: 214 KGIKTTIVCPFFIKTGMFEGCTTGCPSLLPILEPKYAVEKIVEAI 258


>gi|25282469 retinol dehydrogenase 10 [Homo sapiens]
          Length = 341

 Score = 67.0 bits (162), Expect = 2e-11
 Identities = 56/215 (26%), Positives = 95/215 (44%), Gaps = 23/215 (10%)

Query: 13  LALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLL----------------G 56
           + L+TGAGSG+GR  ++  A   A +   D++  + +ET  ++                 
Sbjct: 38  VCLITGAGSGLGRLFALEFARRRALLVLWDINTQSNEETAGMVRHIYRDLEAADAAALQA 97

Query: 57  GPGSKEGPPRGNHAAFQ--ADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLH 114
           G G +E  P  N   F    DV +        E+V+       SV+V+ AG+     LL 
Sbjct: 98  GNGEEEILPHCNLQVFTYTCDVGKRENVYLTAERVRKEVGEV-SVLVNNAGVVSGHHLLE 156

Query: 115 MSEDDWDKVIAVNLKGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKA 174
             ++  ++ + VN    F  T+A    ++     G I+ ++S +G     G  +Y ASK 
Sbjct: 157 CPDELIERTMMVNCHAHFWTTKAFLPTMLEIN-HGHIVTVASSLGLFSTAGVEDYCASKF 215

Query: 175 GVIGLTQTAAREL---GRHGIRCNSVLPGFIATPM 206
           GV+G  ++ + EL    + GI+   V P  + T M
Sbjct: 216 GVVGFHESLSHELKAAEKDGIKTTLVCPYLVDTGM 250


>gi|224922801 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 2
           [Homo sapiens]
          Length = 178

 Score = 65.5 bits (158), Expect = 5e-11
 Identities = 56/176 (31%), Positives = 88/176 (50%), Gaps = 20/176 (11%)

Query: 13  LALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGSKEGPPRGNHAAF 72
           +ALVTGA  GIGRA +  L  +GA VA  D +  A  +    L     ++  P+      
Sbjct: 7   VALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAAL----DEQFEPQKT-LFI 61

Query: 73  QADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDWDKVIAVNL---- 128
           Q DV++ +  R    +V   F R   ++V+ AG+         +E +W+K + +NL    
Sbjct: 62  QCDVADQQQLRDTFRKVVDHFGRL-DILVNNAGVN--------NEKNWEKTLQINLVSVI 112

Query: 129 KGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLTQTAA 184
            GT+L     ++   + G  G IIN+SS+ G +    Q  Y ASK G++G T++AA
Sbjct: 113 SGTYLGLDYMSKQ--NGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAA 166


>gi|209862901 dehydrogenase/reductase (SDR family) member 1 [Homo
           sapiens]
          Length = 313

 Score = 65.5 bits (158), Expect = 5e-11
 Identities = 61/212 (28%), Positives = 91/212 (42%), Gaps = 24/212 (11%)

Query: 9   LRSALALVTGAGSGIGRAVSVRLAGEGATVAAC----DLDRAAAQETVRLLGGPGSKEGP 64
           +   + +VTGA  GIGR ++++L   GATV       D  R  AQE   L          
Sbjct: 5   MNGQVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQEAQSL---------- 54

Query: 65  PRGNHAAFQADVSEARAARCLLEQVQACFSRPPSVVVS--CAGI-----TQDEFLLHMSE 117
             G       D S+    R L EQV         V+V+   AG+     T+++       
Sbjct: 55  -GGQCVPVVCDSSQESEVRSLFEQVDREQQGRLDVLVNNAYAGVQTILNTRNKAFWETPA 113

Query: 118 DDWDKVIAVNLKGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVI 177
             WD +  V L+G +  +   A+ +V  G +G I+ ISS  G +  +    Y   KA   
Sbjct: 114 SMWDDINNVGLRGHYFCSVYGARLMVPAG-QGLIVVISS-PGSLQYMFNVPYGVGKAACD 171

Query: 178 GLTQTAARELGRHGIRCNSVLPGFIATPMTQK 209
            L    A EL RHG+ C S+ PG + T + ++
Sbjct: 172 KLAADCAHELRRHGVSCVSLWPGIVQTELLKE 203


>gi|19923983 dehydrogenase/reductase (SDR family) member 1 [Homo
           sapiens]
          Length = 313

 Score = 65.5 bits (158), Expect = 5e-11
 Identities = 61/212 (28%), Positives = 91/212 (42%), Gaps = 24/212 (11%)

Query: 9   LRSALALVTGAGSGIGRAVSVRLAGEGATVAAC----DLDRAAAQETVRLLGGPGSKEGP 64
           +   + +VTGA  GIGR ++++L   GATV       D  R  AQE   L          
Sbjct: 5   MNGQVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQEAQSL---------- 54

Query: 65  PRGNHAAFQADVSEARAARCLLEQVQACFSRPPSVVVS--CAGI-----TQDEFLLHMSE 117
             G       D S+    R L EQV         V+V+   AG+     T+++       
Sbjct: 55  -GGQCVPVVCDSSQESEVRSLFEQVDREQQGRLDVLVNNAYAGVQTILNTRNKAFWETPA 113

Query: 118 DDWDKVIAVNLKGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVI 177
             WD +  V L+G +  +   A+ +V  G +G I+ ISS  G +  +    Y   KA   
Sbjct: 114 SMWDDINNVGLRGHYFCSVYGARLMVPAG-QGLIVVISS-PGSLQYMFNVPYGVGKAACD 171

Query: 178 GLTQTAARELGRHGIRCNSVLPGFIATPMTQK 209
            L    A EL RHG+ C S+ PG + T + ++
Sbjct: 172 KLAADCAHELRRHGVSCVSLWPGIVQTELLKE 203


>gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A
           [Homo sapiens]
          Length = 300

 Score = 64.7 bits (156), Expect = 8e-11
 Identities = 59/235 (25%), Positives = 99/235 (42%), Gaps = 23/235 (9%)

Query: 4   QLQNRLRSALALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETV---RLLGGPGS 60
           Q +  +   + L+TGAG GIGR  +   A   + +   D+++   +ET    R LG    
Sbjct: 29  QRRKSVAGEIVLITGAGHGIGRQTTYEFAKRQSILVLWDINKRGVEETAAECRKLGVTAH 88

Query: 61  KEGPPRGNHAAFQADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDW 120
                     A+  D S        L QV+       ++VV+ AG      LL   +++ 
Sbjct: 89  ----------AYVVDCSNREEIYRSLNQVKKEVG-DVTIVVNNAGTVYPADLLSTKDEEI 137

Query: 121 DKVIAVNLKGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLT 180
            K   VN+ G F +T+A   +++     G I+ ++S+ G  G      Y +SK   +G  
Sbjct: 138 TKTFEVNILGHFWITKALLPSMMERN-HGHIVTVASVCGHEGIPYLIPYCSSKFAAVGFH 196

Query: 181 QTAARE---LGRHGIRCNSVLP-----GFIATPMTQKVPQKVVDKITEMIPMGHL 227
           +    E   LG+ GI+ + + P     GF   P T+  P    D++   +  G L
Sbjct: 197 RGLTSELQALGKTGIKTSCLCPVFVNTGFTKNPSTRLWPVLETDEVVRSLIDGIL 251


>gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo
           sapiens]
          Length = 325

 Score = 64.3 bits (155), Expect = 1e-10
 Identities = 51/200 (25%), Positives = 96/200 (48%), Gaps = 5/200 (2%)

Query: 9   LRSALALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVR-LLGGPGSKEGPPRG 67
           LR+A+ ++TGA SG+G+  +      GA +  C  +  A +E +R L     +K    + 
Sbjct: 50  LRNAVVVITGATSGLGKECAKVFYAAGAKLVLCGRNGGALEELIRELTASHATKVQTHKP 109

Query: 68  NHAAFQADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDWDKVIAVN 127
               F  D++++ A      ++  CF     ++V+ AGI+    ++  + D   +V+  N
Sbjct: 110 YLVTF--DLTDSGAIVAAAAEILQCFGY-VDILVNNAGISYRGTIMDTTVDVDKRVMETN 166

Query: 128 LKGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLTQTAAREL 187
             G   +T+A   +++    +G I+ ISSI GK+    ++ YAASK            E+
Sbjct: 167 YFGPVALTKALLPSMIKRR-QGHIVAISSIQGKMSIPFRSAYAASKHATQAFFDCLRAEM 225

Query: 188 GRHGIRCNSVLPGFIATPMT 207
            ++ I    + PG+I T ++
Sbjct: 226 EQYEIEVTVISPGYIHTNLS 245


>gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]
          Length = 300

 Score = 62.8 bits (151), Expect = 3e-10
 Identities = 59/240 (24%), Positives = 99/240 (41%), Gaps = 19/240 (7%)

Query: 13  LALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGSKEGPPRGNHAAF 72
           + L+TGAG GIGR  +   A   + +   D+++   +ET     G G+K          F
Sbjct: 38  IVLITGAGHGIGRLTAYEFAKLKSKLVLWDINKHGLEETAAKCKGLGAKV-------HTF 90

Query: 73  QADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDWDKVIAVNLKGTF 132
             D S         ++V+A      S++V+ AG+     L    +   +K   VN+   F
Sbjct: 91  VVDCSNREDIYSSAKKVKAEIG-DVSILVNNAGVVYTSDLFATQDPQIEKTFEVNVLAHF 149

Query: 133 LVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLTQTAARELGR--- 189
             T+A   A+  N   G I+ ++S  G V       Y +SK   +G  +T   EL     
Sbjct: 150 WTTKAFLPAMTKNN-HGHIVTVASAAGHVSVPFLLAYCSSKFAAVGFHKTLTDELAALQI 208

Query: 190 HGIRCNSVLP-----GFIATPMTQKVPQKVVDKITEMIPMGHLGDPE--DVADVVAFLAS 242
            G++   + P     GFI  P T   P    +++   +  G L + +   +   +AFL +
Sbjct: 209 TGVKTTCLCPNFVNTGFIKNPSTSLGPTLEPEEVVNRLMHGILTEQKMIFIPSSIAFLTT 268


>gi|150247226 retinol dehydrogenase 16 [Homo sapiens]
          Length = 317

 Score = 62.8 bits (151), Expect = 3e-10
 Identities = 55/212 (25%), Positives = 94/212 (44%), Gaps = 23/212 (10%)

Query: 4   QLQNRLRSALALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGSKEG 63
           Q+ + LR     +TG  SG G+ ++ +L   G  V A  L    A++            G
Sbjct: 22  QVLSHLRDKYVFITGCDSGFGKLLARQLDARGLRVLAACLTEKGAEQL----------RG 71

Query: 64  PPRGNHAAFQADVSEARAARCLLEQVQACFSRPPSV--VVSCAGIT----QDEFLLHMSE 117
                      DV++  +     + V+ C  R   +  +V+ AGI+     +E L   ++
Sbjct: 72  QTSDRLETVTLDVTKTESVAAAAQWVKECV-RDKGLWGLVNNAGISLPTAPNELL---TK 127

Query: 118 DDWDKVIAVNLKGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVI 177
            D+  ++ VNL G   VT +    +     RG ++N+SS++G+V   G   Y  SK GV 
Sbjct: 128 QDFVTILDVNLLGVIDVTLSLLPLV--RRARGRVVNVSSVMGRVSLFGG-GYCISKYGVE 184

Query: 178 GLTQTAARELGRHGIRCNSVLPGFIATPMTQK 209
             + +  REL   G++   + PG+  T +T K
Sbjct: 185 AFSDSLRRELSYFGVKVAMIEPGYFKTAVTSK 216


>gi|126723191 dehydrogenase/reductase (SDR family) member 4 like 2
           [Homo sapiens]
          Length = 232

 Score = 62.8 bits (151), Expect = 3e-10
 Identities = 56/198 (28%), Positives = 85/198 (42%), Gaps = 11/198 (5%)

Query: 1   MASQLQNR---LRSALALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGG 57
           MAS    R   L + +ALVT +  GIG A++ RLA + A V      +    + V  L G
Sbjct: 19  MASSRMTRRDPLTNKVALVTASTDGIGFAIARRLAQDRAHVVVSSRKQQNVDQAVATLQG 78

Query: 58  PGSKEGPPRGNHAAFQADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSE 117
            G                V +A     L+            +V + A       L+ ++E
Sbjct: 79  EGLSV-------TGTVCHVGKAEDRERLVAMAVKLHGGIDILVSNAAVNPFFGSLMDVTE 131

Query: 118 DDWDKVIAVNLKGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVI 177
           + WDK + +N+K   L+T+A    +   G  GS++ +SSI     + G + Y  SK  ++
Sbjct: 132 EVWDKTLDINVKAPALMTKAVVPEMEKRG-GGSVVIVSSIAAFSPSPGFSPYNVSKTALL 190

Query: 178 GLTQTAARELGRHGIRCN 195
           GL  T A EL    IR N
Sbjct: 191 GLNNTLAIELAPRNIRVN 208


>gi|223646115 short chain dehydrogenase/reductase family 16C, member
           6 [Homo sapiens]
          Length = 323

 Score = 59.3 bits (142), Expect = 3e-09
 Identities = 59/213 (27%), Positives = 96/213 (45%), Gaps = 22/213 (10%)

Query: 13  LALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGSKEGPPRGNHAAF 72
           + L TGAGSG+GR +++  A  GA +   D+++    ET RL    G K+  P      +
Sbjct: 38  IVLTTGAGSGLGRQLAIYFARFGAILVLWDVNQEGNMETCRLAKEKGGKKVFP------Y 91

Query: 73  QADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDWDKVIAVNLKGTF 132
             D S  +    + +QV+  F    +++V+ A +   +  L + +   +K   VN    F
Sbjct: 92  TCDCSNRQEVYRVADQVRKEFG-DVTILVNNADLVTGKPFLDIPDHMVEKSFLVNAITHF 150

Query: 133 LVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTN-------YAASKAGVIGLTQTAAR 185
              +A   A++     G ++ ISSI G VG  G ++       Y+ASK    G  ++   
Sbjct: 151 WTCKAFLPAVIKAN-HGHLVCISSIAGVVGINGLSDEYFVSPYYSASKFAAFGFAESLFF 209

Query: 186 EL---GRHGIRCNSVLPGFIATPM----TQKVP 211
           EL    +  ++   V P FI T M    T K P
Sbjct: 210 ELTMIKKTEVKSTIVCPHFINTGMFEGCTSKYP 242


>gi|50726952 retinol dehydrogenase 5 (11-cis and 9-cis) [Homo
           sapiens]
          Length = 318

 Score = 59.3 bits (142), Expect = 3e-09
 Identities = 53/199 (26%), Positives = 92/199 (46%), Gaps = 15/199 (7%)

Query: 11  SALALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGSKEGPPRGNHA 70
           +A   +TG  SG GR ++++L   G  V A  L  + A++  R+              H 
Sbjct: 28  NAFVFITGCDSGFGRLLALQLDQRGFRVLASCLTPSGAEDLQRVASSR---------LHT 78

Query: 71  AFQADVSEARAARCLLEQVQACFSRPPSV-VVSCAGITQDEFLLH-MSEDDWDKVIAVNL 128
               D+++ ++ +   + V+          +V+ AG+         ++ DD+ +V+ VN 
Sbjct: 79  TL-LDITDPQSVQQAAKWVEMHVKEAGLFGLVNNAGVAGIIGPTPWLTRDDFQRVLNVNT 137

Query: 129 KGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLTQTAARELG 188
            G   VT A    L     RG +INI+S++G++   G   Y  SK G+   + +  R++ 
Sbjct: 138 MGPIGVTLALLPLLQQ--ARGRVINITSVLGRLAANGG-GYCVSKFGLEAFSDSLRRDVA 194

Query: 189 RHGIRCNSVLPGFIATPMT 207
             GIR + V PGF  TP+T
Sbjct: 195 HFGIRVSIVEPGFFRTPVT 213


>gi|10190746 retinol dehydrogenase 14 (all-trans and 9-cis) [Homo
           sapiens]
          Length = 336

 Score = 56.6 bits (135), Expect = 2e-08
 Identities = 63/249 (25%), Positives = 107/249 (42%), Gaps = 25/249 (10%)

Query: 15  LVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQET-------VRLLGGPGSKEGPPR- 66
           L+TGA SG+GRA +  L   GA V     DRA A+E        +R     G + G    
Sbjct: 47  LITGANSGLGRATAAELLRLGARVIMGCRDRARAEEAAGQLRRELRQAAECGPEPGVSGV 106

Query: 67  GNHAAFQADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDWDKVIAV 126
           G     + D++  R+ R   +++     R   V+++ AGI Q  ++   +ED ++    V
Sbjct: 107 GELIVRELDLASLRSVRAFCQEMLQEEPR-LDVLINNAGIFQCPYM--KTEDGFEMQFGV 163

Query: 127 NLKGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTN------------YAASKA 174
           N  G FL+T      L+ +     I+ +SS + K G++   +            Y+ SK 
Sbjct: 164 NHLGHFLLTNLLL-GLLKSSAPSRIVVVSSKLYKYGDINFDDLNSEQSYNKSFCYSRSKL 222

Query: 175 GVIGLTQTAARELGRHGIRCNSVLPGFIATPMTQKVP-QKVVDKITEMIPMGHLGDPEDV 233
             I  T+  AR L    +  N + PG + T + + +    +V  +  ++       P + 
Sbjct: 223 ANILFTRELARRLEGTNVTVNVLHPGIVRTNLGRHIHIPLLVKPLFNLVSWAFFKTPVEG 282

Query: 234 ADVVAFLAS 242
           A    +LAS
Sbjct: 283 AQTSIYLAS 291


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.132    0.379 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,302,745
Number of Sequences: 37866
Number of extensions: 400780
Number of successful extensions: 1307
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 57
Number of HSP's successfully gapped in prelim test: 30
Number of HSP's that attempted gapping in prelim test: 1170
Number of HSP's gapped (non-prelim): 102
length of query: 261
length of database: 18,247,518
effective HSP length: 100
effective length of query: 161
effective length of database: 14,460,918
effective search space: 2328207798
effective search space used: 2328207798
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.