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Search of human proteins with 150170729
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|150170729 microtubule associated serine/threonine kinase 3
[Homo sapiens]
(1309 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|150170729 microtubule associated serine/threonine kinase 3 [H... 2612 0.0
gi|148727255 microtubule associated serine/threonine kinase fami... 1506 0.0
gi|112363080 microtubule associated serine/threonine kinase 2 [H... 1479 0.0
gi|45120119 microtubule associated serine/threonine kinase 1 [Ho... 1421 0.0
gi|4502023 AKT2 kinase [Homo sapiens] 231 3e-60
gi|24307971 serine/threonine kinase 38 like [Homo sapiens] 230 8e-60
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 224 4e-58
gi|62241015 AKT1 kinase [Homo sapiens] 223 9e-58
gi|62241013 AKT1 kinase [Homo sapiens] 223 9e-58
gi|62241011 AKT1 kinase [Homo sapiens] 223 9e-58
gi|5453976 protein kinase C, theta [Homo sapiens] 221 4e-57
gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Hom... 221 4e-57
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 221 5e-57
gi|6005814 serine/threonine kinase 38 [Homo sapiens] 219 1e-56
gi|4885583 Rho-associated, coiled-coil containing protein kinase... 219 2e-56
gi|126091095 myotonic dystrophy protein kinase isoform 1 [Homo s... 218 2e-56
gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 218 4e-56
gi|47059024 myotonic dystrophy protein kinase isoform 2 [Homo sa... 217 5e-56
gi|126091040 myotonic dystrophy protein kinase isoform 4 [Homo s... 217 7e-56
gi|126131093 myotonic dystrophy protein kinase isoform 3 [Homo s... 217 7e-56
gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 216 9e-56
gi|5453974 protein kinase N2 [Homo sapiens] 216 1e-55
gi|28557781 protein kinase C, eta [Homo sapiens] 215 3e-55
gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Ho... 214 3e-55
gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens] 214 3e-55
gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 213 7e-55
gi|41872583 Rho-associated, coiled-coil containing protein kinas... 213 1e-54
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 213 1e-54
gi|47132591 protein kinase N1 isoform 1 [Homo sapiens] 213 1e-54
gi|47132589 protein kinase N1 isoform 2 [Homo sapiens] 213 1e-54
>gi|150170729 microtubule associated serine/threonine kinase 3 [Homo
sapiens]
Length = 1309
Score = 2612 bits (6769), Expect = 0.0
Identities = 1309/1309 (100%), Positives = 1309/1309 (100%)
Query: 1 MDESSLLRRRGLQKELSLPRRGRGCRSGNRKSLVVGTPSPTLSRPLSPLSVPTAGSSPLD 60
MDESSLLRRRGLQKELSLPRRGRGCRSGNRKSLVVGTPSPTLSRPLSPLSVPTAGSSPLD
Sbjct: 1 MDESSLLRRRGLQKELSLPRRGRGCRSGNRKSLVVGTPSPTLSRPLSPLSVPTAGSSPLD 60
Query: 61 SPRNFSAASALNFPFARRADGRRWSLASLPSSGYGTNTPSSTLSSSSSSRERLHQLPFQP 120
SPRNFSAASALNFPFARRADGRRWSLASLPSSGYGTNTPSSTLSSSSSSRERLHQLPFQP
Sbjct: 61 SPRNFSAASALNFPFARRADGRRWSLASLPSSGYGTNTPSSTLSSSSSSRERLHQLPFQP 120
Query: 121 TPDELHFLSKHFRSSENVLDEEGGRSPRLRPRSRSLSPGRATGTFDNEIVMMNHVYRERF 180
TPDELHFLSKHFRSSENVLDEEGGRSPRLRPRSRSLSPGRATGTFDNEIVMMNHVYRERF
Sbjct: 121 TPDELHFLSKHFRSSENVLDEEGGRSPRLRPRSRSLSPGRATGTFDNEIVMMNHVYRERF 180
Query: 181 PKATAQMEGRLQEFLTAYAPGARLALADGVLGFIHHQIVELARDCLAKSGENLVTSRYFL 240
PKATAQMEGRLQEFLTAYAPGARLALADGVLGFIHHQIVELARDCLAKSGENLVTSRYFL
Sbjct: 181 PKATAQMEGRLQEFLTAYAPGARLALADGVLGFIHHQIVELARDCLAKSGENLVTSRYFL 240
Query: 241 EMQEKLERLLQDAHERSDSEEVSFIVQLVRKLLIIISRPARLLECLEFDPEEFYHLLEAA 300
EMQEKLERLLQDAHERSDSEEVSFIVQLVRKLLIIISRPARLLECLEFDPEEFYHLLEAA
Sbjct: 241 EMQEKLERLLQDAHERSDSEEVSFIVQLVRKLLIIISRPARLLECLEFDPEEFYHLLEAA 300
Query: 301 EGHAREGQGIKTDLPQYIIGQLGLAKDPLEEMVPLSHLEEEQPPAPESPESRALVGQSRR 360
EGHAREGQGIKTDLPQYIIGQLGLAKDPLEEMVPLSHLEEEQPPAPESPESRALVGQSRR
Sbjct: 301 EGHAREGQGIKTDLPQYIIGQLGLAKDPLEEMVPLSHLEEEQPPAPESPESRALVGQSRR 360
Query: 361 KPCESDFETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILT 420
KPCESDFETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILT
Sbjct: 361 KPCESDFETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILT 420
Query: 421 FAENPFVVSMFCSFETRRHLCMVMEYVEGGDCATLLKNMGPLPVDMARLYFAETVLALEY 480
FAENPFVVSMFCSFETRRHLCMVMEYVEGGDCATLLKNMGPLPVDMARLYFAETVLALEY
Sbjct: 421 FAENPFVVSMFCSFETRRHLCMVMEYVEGGDCATLLKNMGPLPVDMARLYFAETVLALEY 480
Query: 481 LHNYGIVHRDLKPDNLLITSLGHIKLTDFGLSKIGLMSMATNLYEGHIEKDAREFIDKQV 540
LHNYGIVHRDLKPDNLLITSLGHIKLTDFGLSKIGLMSMATNLYEGHIEKDAREFIDKQV
Sbjct: 481 LHNYGIVHRDLKPDNLLITSLGHIKLTDFGLSKIGLMSMATNLYEGHIEKDAREFIDKQV 540
Query: 541 CGTPEYIAPEVIFRQGYGKPVDWWAMGVVLYEFLVGCVPFFGDTPEELFGQVVSDEIMWP 600
CGTPEYIAPEVIFRQGYGKPVDWWAMGVVLYEFLVGCVPFFGDTPEELFGQVVSDEIMWP
Sbjct: 541 CGTPEYIAPEVIFRQGYGKPVDWWAMGVVLYEFLVGCVPFFGDTPEELFGQVVSDEIMWP 600
Query: 601 EGDEALPADAQDLITRLLRQSPLDRLGTGGTHEVKQHPFFLALDWAGLLRHKAEFVPQLE 660
EGDEALPADAQDLITRLLRQSPLDRLGTGGTHEVKQHPFFLALDWAGLLRHKAEFVPQLE
Sbjct: 601 EGDEALPADAQDLITRLLRQSPLDRLGTGGTHEVKQHPFFLALDWAGLLRHKAEFVPQLE 660
Query: 661 AEDDTSYFDTRSERYRHLGSEDDETNDEESSTEIPQFSSCSHRFSKVYSSSEFLAVQPTP 720
AEDDTSYFDTRSERYRHLGSEDDETNDEESSTEIPQFSSCSHRFSKVYSSSEFLAVQPTP
Sbjct: 661 AEDDTSYFDTRSERYRHLGSEDDETNDEESSTEIPQFSSCSHRFSKVYSSSEFLAVQPTP 720
Query: 721 TFAERSFSEDREEGWERSEVDYGRRLSADIRLRSWTSSGSSCQSSSSQPERGPSPSLLNT 780
TFAERSFSEDREEGWERSEVDYGRRLSADIRLRSWTSSGSSCQSSSSQPERGPSPSLLNT
Sbjct: 721 TFAERSFSEDREEGWERSEVDYGRRLSADIRLRSWTSSGSSCQSSSSQPERGPSPSLLNT 780
Query: 781 ISLDTMPKFAFSSEDEGVGPGPAGPKRPVFILGEPDPPPAATPVMPKPSSLSADTAALSH 840
ISLDTMPKFAFSSEDEGVGPGPAGPKRPVFILGEPDPPPAATPVMPKPSSLSADTAALSH
Sbjct: 781 ISLDTMPKFAFSSEDEGVGPGPAGPKRPVFILGEPDPPPAATPVMPKPSSLSADTAALSH 840
Query: 841 ARLRSNSIGARHSTPRPLDAGRGRRLGGPRDPAPEKSRASSSGGSGGGSGGRVPKSASVS 900
ARLRSNSIGARHSTPRPLDAGRGRRLGGPRDPAPEKSRASSSGGSGGGSGGRVPKSASVS
Sbjct: 841 ARLRSNSIGARHSTPRPLDAGRGRRLGGPRDPAPEKSRASSSGGSGGGSGGRVPKSASVS 900
Query: 901 ALSLIITADDGSGGPLMSPLSPRSLSSNPSSRDSSPSRDPSPVCGSLRPPIVIHSSGKKY 960
ALSLIITADDGSGGPLMSPLSPRSLSSNPSSRDSSPSRDPSPVCGSLRPPIVIHSSGKKY
Sbjct: 901 ALSLIITADDGSGGPLMSPLSPRSLSSNPSSRDSSPSRDPSPVCGSLRPPIVIHSSGKKY 960
Query: 961 GFSLRAIRVYMGDSDVYTVHHVVWSVEDGSPAQEAGLRAGDLITHINGESVLGLVHMDVV 1020
GFSLRAIRVYMGDSDVYTVHHVVWSVEDGSPAQEAGLRAGDLITHINGESVLGLVHMDVV
Sbjct: 961 GFSLRAIRVYMGDSDVYTVHHVVWSVEDGSPAQEAGLRAGDLITHINGESVLGLVHMDVV 1020
Query: 1021 ELLLKSGNKISLRTTALENTSIKVGPARKNVAKGRMARRSKRSRRRETQDRRKSLFKKIS 1080
ELLLKSGNKISLRTTALENTSIKVGPARKNVAKGRMARRSKRSRRRETQDRRKSLFKKIS
Sbjct: 1021 ELLLKSGNKISLRTTALENTSIKVGPARKNVAKGRMARRSKRSRRRETQDRRKSLFKKIS 1080
Query: 1081 KQTSVLHTSRSFSSGLHHSLSSSESLPGSPTHSLSPSPTTPCRSPAPDVPADTTASPPSA 1140
KQTSVLHTSRSFSSGLHHSLSSSESLPGSPTHSLSPSPTTPCRSPAPDVPADTTASPPSA
Sbjct: 1081 KQTSVLHTSRSFSSGLHHSLSSSESLPGSPTHSLSPSPTTPCRSPAPDVPADTTASPPSA 1140
Query: 1141 SPSSSSPASPAAAGHTRPSSLHGLAAKLGPPRPKTGRRKSTSSIPPSPLACPPISAPPPR 1200
SPSSSSPASPAAAGHTRPSSLHGLAAKLGPPRPKTGRRKSTSSIPPSPLACPPISAPPPR
Sbjct: 1141 SPSSSSPASPAAAGHTRPSSLHGLAAKLGPPRPKTGRRKSTSSIPPSPLACPPISAPPPR 1200
Query: 1201 SPSPLPGHPPAPARSPRLRRGQSADKLGTGERLDGEAGRRTRGPEAELVVMRRLHLSERR 1260
SPSPLPGHPPAPARSPRLRRGQSADKLGTGERLDGEAGRRTRGPEAELVVMRRLHLSERR
Sbjct: 1201 SPSPLPGHPPAPARSPRLRRGQSADKLGTGERLDGEAGRRTRGPEAELVVMRRLHLSERR 1260
Query: 1261 DSFKKQEAVQEVSFDEPQEEATGLPTSVPQIAVEGEEAVPVALGPTGRD 1309
DSFKKQEAVQEVSFDEPQEEATGLPTSVPQIAVEGEEAVPVALGPTGRD
Sbjct: 1261 DSFKKQEAVQEVSFDEPQEEATGLPTSVPQIAVEGEEAVPVALGPTGRD 1309
>gi|148727255 microtubule associated serine/threonine kinase family
member 4 isoform a [Homo sapiens]
Length = 2434
Score = 1506 bits (3899), Expect = 0.0
Identities = 812/1347 (60%), Positives = 976/1347 (72%), Gaps = 101/1347 (7%)
Query: 1 MDESSLLRRRGLQKELSLPRRG------------RGCRSGNRKSLVVGTPSPTLSRPLSP 48
MDESS+LRRRGLQKELSLPRRG + CR+ NRKSL+ SP L RP SP
Sbjct: 1 MDESSILRRRGLQKELSLPRRGSLIDSQKWNCLVKRCRTSNRKSLIGNGQSPALPRPHSP 60
Query: 49 LSVPTAGSSPLDSPRNFSAASALNFPFARRADGRRWSLASLPSSGYGTNTPSSTLSSSSS 108
LS AG+SP DSPRNFS +++ +F FARR DGRRWSLASLPSSGYGTNTPSST+SSS S
Sbjct: 61 LSAH-AGNSPQDSPRNFSPSASAHFSFARRTDGRRWSLASLPSSGYGTNTPSSTVSSSCS 119
Query: 109 SRERLHQLPFQPTPDELHFLSKHFRSSENVLDEEGGRSPRLRPRSRSLSPGRATGTFDNE 168
S+E+LHQLP+QPTPDELHFLSKHF ++E++ E R+ +RPRSRSLSPGR+ D+E
Sbjct: 120 SQEKLHQLPYQPTPDELHFLSKHFCTTESIATENRCRNTPMRPRSRSLSPGRSPACCDHE 179
Query: 169 IVMMNHVYRERFPKATAQMEGRLQEFLTAYAPGARLALADGVLGFIHHQIVELARDCLAK 228
I+MMNHVY+ERFPKATAQME RL+E +T+Y+P L LADGVL F HHQI+ELARDCL K
Sbjct: 180 IIMMNHVYKERFPKATAQMEERLKEIITSYSPDNVLPLADGVLSFTHHQIIELARDCLDK 239
Query: 229 SGENLVTSRYFLEMQEKLERLLQDAHERSDSEEVSFIVQLVRKLLIIISRPARLLECLEF 288
S + L+TSRYFLE+Q KL++LLQ+AH+RS+S E++FI QLVRK+LI+I+RPARLLECLEF
Sbjct: 240 SHQGLITSRYFLELQHKLDKLLQEAHDRSESGELAFIKQLVRKILIVIARPARLLECLEF 299
Query: 289 DPEEFYHLLEAAEGHAREGQGIKTDLPQYIIGQLGLAKDPLEEMVPLSHLEEEQPPAPES 348
DPEEFY+LLEAAEGHA+EGQGIKTD+P+YII QLGL KDPLEEM L + + PE+
Sbjct: 300 DPEEFYYLLEAAEGHAKEGQGIKTDIPRYIISQLGLNKDPLEEMAHLGNYDSGTAETPET 359
Query: 349 PESRALVGQS---RRKPCESDFETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLIL 405
ES + S RRKP ESDFETIKLISNGAYGAVY VRH+++RQRFA+KKINKQNLIL
Sbjct: 360 DESVSSSNASLKLRRKPRESDFETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLIL 419
Query: 406 RNQIQQVFVERDILTFAENPFVVSMFCSFETRRHLCMVMEYVEGGDCATLLKNMGPLPVD 465
RNQIQQ FVERDILTFAENPFVVSM+CSFETRRHLCMVMEYVEGGDCATL+KNMGPLPVD
Sbjct: 420 RNQIQQAFVERDILTFAENPFVVSMYCSFETRRHLCMVMEYVEGGDCATLMKNMGPLPVD 479
Query: 466 MARLYFAETVLALEYLHNYGIVHRDLKPDNLLITSLGHIKLTDFGLSKIGLMSMATNLYE 525
MAR+YFAETVLALEYLHNYGIVHRDLKPDNLL+TS+GHIKLTDFGLSK+GLMSM TNLYE
Sbjct: 480 MARMYFAETVLALEYLHNYGIVHRDLKPDNLLVTSMGHIKLTDFGLSKVGLMSMTTNLYE 539
Query: 526 GHIEKDAREFIDKQVCGTPEYIAPEVIFRQGYGKPVDWWAMGVVLYEFLVGCVPFFGDTP 585
GHIEKDAREF+DKQVCGTPEYIAPEVI RQGYGKPVDWWAMG++LYEFLVGCVPFFGDTP
Sbjct: 540 GHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTP 599
Query: 586 EELFGQVVSDEIMWPEGDEALPADAQDLITRLLRQSPLDRLGTGGTHEVKQHPFFLALDW 645
EELFGQV+SDEI WPE DEA P DAQDLIT LLRQ+PL+RLGTGG +EVKQH FF +LDW
Sbjct: 600 EELFGQVISDEINWPEKDEAPPPDAQDLITLLLRQNPLERLGTGGAYEVKQHRFFRSLDW 659
Query: 646 AGLLRHKAEFVPQLEAEDDTSYFDTRSERYRHLGS-EDDETNDEESSTEIPQFSSCSHRF 704
LLR KAEF+PQLE+EDDTSYFDTRSE+Y H+ + E+D+TNDE+ + EI QFSSCSHRF
Sbjct: 660 NSLLRQKAEFIPQLESEDDTSYFDTRSEKYHHMETEEEDDTNDEDFNVEIRQFSSCSHRF 719
Query: 705 SKVYSSSEFLAVQPTPTFAERSFSEDREEGWERSEVDYGRRLSADIRLRSWTSSGSSCQS 764
SKV+SS + + ++ +E++E+ ++++ SW+S S Q
Sbjct: 720 SKVFSSIDRIT---------QNSAEEKEDSVDKTK----STTLPSTETLSWSSEYSEMQQ 766
Query: 765 SSSQPERGPSPSLLNTISLDTMPKFAFSSE---DEGVG-PG-----PAGPKRP--VFILG 813
S+ + S + +S +PK A S+E DE PG P P P
Sbjct: 767 LSTS-NSSDTESNRHKLSSGLLPKLAISTEGEQDEAASCPGDPHEEPGKPALPPEECAQE 825
Query: 814 EPDPPPAATPVMPKPSSLSADTAALSHARLRSNSIGARHSTPRPLDAGRGRRLGGPRDPA 873
EP+ A+ + S+ + + L RS + + ++ +P +PA
Sbjct: 826 EPEVTTPASTISSSTLSVGSFSEHLDQINGRSECVDSTDNSSKP-----------SSEPA 874
Query: 874 PEKSRASSSGGSGGGSGGRVPKSASVSALSLIITADDGSGGPLMSPLSPRSLSSNP-SSR 932
+R G+V KS S SALSL+I D + PL SP+SP SLSS+P SSR
Sbjct: 875 SHMARQRLESTEKKKISGKVTKSLSASALSLMIPGDMFAVSPLGSPMSPHSLSSDPSSSR 934
Query: 933 DSSPSRDPSPVCGSLRPPIVIHSSGKKYGFSLRAIRVYMGDSDVYTVHHVVWSVEDGSPA 992
DSSPSRD S S PIVIHSSGK YGF++RAIRVY+GDSD+YTVHH+VW+VE+GSPA
Sbjct: 935 DSSPSRDSSAASASPHQPIVIHSSGKNYGFTIRAIRVYVGDSDIYTVHHIVWNVEEGSPA 994
Query: 993 QEAGLRAGDLITHINGESVLGLVHMDVVELLLKSGNKISLRTTALENTSIKVGPARKNVA 1052
+AGL+AGDLITHINGE V GLVH +V+ELLLKSGNK+S+ TT ENTSIK GPAR+N
Sbjct: 995 CQAGLKAGDLITHINGEPVHGLVHTEVIELLLKSGNKVSITTTPFENTSIKTGPARRNSY 1054
Query: 1053 KGRMARRSKRSRRRETQDRRKSLFKKISKQTS-VLHTSRSFSSGLHHSLSSSESLPGSPT 1111
K RM RRSK+S+++E+ +RR+SLFKK++KQ S +LHTSRSFS L+ SLSS ESLPGSPT
Sbjct: 1055 KSRMVRRSKKSKKKESLERRRSLFKKLAKQPSPLLHTSRSFSC-LNRSLSSGESLPGSPT 1113
Query: 1112 HSLSPSPTTPCRSPAPDVPADTTASPPSASPSSSSPASPAAAGHTRPSSLHGLAAKLGPP 1171
HSLSP TP PD P+ T +S S+SPSSS+P SPA +GH RPS+LHGLA KLG
Sbjct: 1114 HSLSPRSPTPSYRSTPDFPSGTNSS-QSSSPSSSAPNSPAGSGHIRPSTLHGLAPKLGGQ 1172
Query: 1172 RPKTGRRKSTSSIPPSPLACPPISAP----PPRSPSPLPGH-----------------PP 1210
R ++GRRKS +IP SPLA P P P RSPSPL GH PP
Sbjct: 1173 RYRSGRRKSAGNIPLSPLARTPSPTPQPTSPQRSPSPLLGHSLGNSKIAQAFPSKMHSPP 1232
Query: 1211 A------------PARSPRLRRGQSADKLGTGERLDGEAGRRTRGPEAELVVMRRLHLSE 1258
P RSP L+R QS +KL + G + + + R+ L
Sbjct: 1233 TIVRHIVRPKSAEPPRSPLLKRVQSEEKLSP-----------SYGSDKKHLCSRKHSLEV 1281
Query: 1259 RRDSFKKQEAVQEVSFDEPQEEATGLP 1285
++ +++++ +E E +P
Sbjct: 1282 TQEEVQREQSQREAPLQSLDENVCDVP 1308
Score = 42.0 bits (97), Expect = 0.004
Identities = 43/177 (24%), Positives = 69/177 (38%), Gaps = 12/177 (6%)
Query: 1065 RRETQDRRKSLFKKISKQTSVLHTSRSFSSGLHHSLSSSESLPGSPTHSLSPSPTTPCRS 1124
RR + + ++L + S Q + + +S SL + P P P
Sbjct: 1887 RRGVEPKPEALLARRSLQPPGIESEKSEKLSSFPSLQKDGAK--EPERKEQPLQRHPSSI 1944
Query: 1125 PAPDVPADTTASPPS----ASPSSSSPASPAAAGHTRPSSLHGLAAKLGPPRPKTGRRKS 1180
P P + A +SP + +SPS +S P A +PS+ ++ PP+P +S
Sbjct: 1945 PPPPLTAKDLSSPAARQHCSSPSHASGREPGA----KPSTAEPSSSPQDPPKPVAAHSES 2000
Query: 1181 TSSIP-PSPLACPPISAPPPRS-PSPLPGHPPAPARSPRLRRGQSADKLGTGERLDG 1235
+S P P P PP + P RS S P + P + + + G G G
Sbjct: 2001 SSHKPRPGPDPGPPKTKHPDRSLSSQKPSVGATKGKEPATQSLGGSSREGKGHSKSG 2057
Score = 32.7 bits (73), Expect = 2.3
Identities = 47/196 (23%), Positives = 66/196 (33%), Gaps = 30/196 (15%)
Query: 1048 RKNVAKGRMARRSKRSRRR-----------------ETQDRRKSLFK------KISKQTS 1084
R++ +G RS+RS R +T D K+L QT
Sbjct: 1782 RESSERGPPTARSERSAARADTCREPSMELCFPETAKTSDNSKNLLSVGRTHPDFYTQTQ 1841
Query: 1085 VLHTSRSFSSGLHHSLSSSESLPGSPTHSLSPSPTTPCRSPAPDVPADTTASPPS--ASP 1142
+ + + +H E+ P +S S PC V P + A
Sbjct: 1842 AMEKAWAPGGKTNHKDGPGEARPPPRDNSSLHSAGIPCEKELGKVRRGVEPKPEALLARR 1901
Query: 1143 SSSSPASPAAAGHTRPS--SLHGLAAKLGPPRPKTGRRKSTSSIPPSPLACPPISAPPPR 1200
S P + S SL AK P R + ++ SSIPP PL +S+P R
Sbjct: 1902 SLQPPGIESEKSEKLSSFPSLQKDGAK-EPERKEQPLQRHPSSIPPPPLTAKDLSSPAAR 1960
Query: 1201 SPSPLPGHPPAPARSP 1216
P H A R P
Sbjct: 1961 QHCSSPSH--ASGREP 1974
>gi|112363080 microtubule associated serine/threonine kinase 2 [Homo
sapiens]
Length = 1798
Score = 1479 bits (3830), Expect = 0.0
Identities = 833/1405 (59%), Positives = 986/1405 (70%), Gaps = 135/1405 (9%)
Query: 14 KELSLPRRGRGCRSGNRKSLVV-GTPSPTLSRPLSPLSVPTAGSSPLDSPRNFSAASALN 72
KELSLPRRG CR+ NRKSL+V + SPTL RP SPL T G+SPLDSPRNFS + +
Sbjct: 157 KELSLPRRGSFCRTSNRKSLIVTSSTSPTLPRPHSPLHGHT-GNSPLDSPRNFSPNAPAH 215
Query: 73 FPF--ARRADGRRWSLASLPSSGYGTNTPSSTLSSSSSSRERLHQLPFQPTPDELHFLSK 130
F F ARR DGRRWSLASLPSSGYGTNTPSST+SSS SS+E+LHQLPFQPT DELHFL+K
Sbjct: 216 FSFVPARRTDGRRWSLASLPSSGYGTNTPSSTVSSSCSSQEKLHQLPFQPTADELHFLTK 275
Query: 131 HFRSSENVLDEEGGRSPRLRPRSRSLSPGRATGTFDNEIVMMNHVYRERFPKATAQMEGR 190
HF S+E+V DEEG +SP +RPRSRSLSPGR+ +FD+EI+MMNHVY+ERFPKATAQME R
Sbjct: 276 HF-STESVPDEEGRQSPAMRPRSRSLSPGRSPVSFDSEIIMMNHVYKERFPKATAQMEER 334
Query: 191 LQEFLTAYAPGARLALADGVLGFIHHQIVELARDCLAKSGENLVTSRYFLEMQEKLERLL 250
L EF+++ P + L LADG L FIHHQ++E+ARDCL KS L+TS+YF E+Q+ LE+LL
Sbjct: 335 LAEFISSNTPDSVLPLADGALSFIHHQVIEMARDCLDKSRSGLITSQYFYELQDNLEKLL 394
Query: 251 QDAHERSDSEEVSFIVQLVRKLLIIISRPARLLECLEFDPEEFYHLLEAAEGHAREGQGI 310
QDAHERS+S EV+F++QLV+KL+III+RPARLLECLEFDPEEFYHLLEAAEGHA+EGQGI
Sbjct: 395 QDAHERSESSEVAFVMQLVKKLMIIIARPARLLECLEFDPEEFYHLLEAAEGHAKEGQGI 454
Query: 311 KTDLPQYIIGQLGLAKDPLEEMVPLSHLEE-EQPPAPESPESRALVGQSRRKPCESDFET 369
K D+P+YI+ QLGL +DPLEEM LS + + P +S E S++ P E DFET
Sbjct: 455 KCDIPRYIVSQLGLTRDPLEEMAQLSSCDSPDTPETDDSIEGHGASLPSKKTPSEEDFET 514
Query: 370 IKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILTFAENPFVVS 429
IKLISNGAYGAV+LVRH+ TRQRFA+KKINKQNLILRNQIQQ FVERDILTFAENPFVVS
Sbjct: 515 IKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVS 574
Query: 430 MFCSFETRRHLCMVMEYVEGGDCATLLKNMGPLPVDMARLYFAETVLALEYLHNYGIVHR 489
MFCSF+T+RHLCMVMEYVEGGDCATLLKN+G LPVDM RLYFAETVLALEYLHNYGIVHR
Sbjct: 575 MFCSFDTKRHLCMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVLALEYLHNYGIVHR 634
Query: 490 DLKPDNLLITSLGHIKLTDFGLSKIGLMSMATNLYEGHIEKDAREFIDKQVCGTPEYIAP 549
DLKPDNLLITS+GHIKLTDFGLSKIGLMS+ TNLYEGHIEKDAREF+DKQVCGTPEYIAP
Sbjct: 635 DLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAP 694
Query: 550 EVIFRQGYGKPVDWWAMGVVLYEFLVGCVPFFGDTPEELFGQVVSDEIMWPEGDEALPAD 609
EVI RQGYGKPVDWWAMG++LYEFLVGCVPFFGDTPEELFGQV+SDEI+WPEGDEALP D
Sbjct: 695 EVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEIVWPEGDEALPPD 754
Query: 610 AQDLITRLLRQSPLDRLGTGGTHEVKQHPFFLALDWAGLLRHKAEFVPQLEAEDDTSYFD 669
AQDL ++LL Q+PL+RLGTG +EVKQHPFF LDW GLLR KAEF+PQLE+EDDTSYFD
Sbjct: 755 AQDLTSKLLHQNPLERLGTGSAYEVKQHPFFTGLDWTGLLRQKAEFIPQLESEDDTSYFD 814
Query: 670 TRSERYRHLGSEDDETNDEESSTEIPQFSSCSHRFSKVYSSSEFLAV---QPTPTFAERS 726
TRSERY H+ SED+E E+ EI QFSSCS RF+KVYSS E L++ + TP +RS
Sbjct: 815 TRSERYHHMDSEDEEEVSEDGCLEIRQFSSCSPRFNKVYSSMERLSLLEERRTPPPTKRS 874
Query: 727 FSEDREE---------GWERSEVDYGRRLSADIRLRSWTSSGSSCQSSSSQP--ERGPSP 775
SE++E+ G +RS V + +R R S S +S SS P R
Sbjct: 875 LSEEKEDHSDGLAGLKGRDRSWVIGSPEI---LRKRLSVSESSHTESDSSPPMTVRRRCS 931
Query: 776 SLLNTISLDTMPKFAFSSEDEGVGPGPAGPKRPVFILGEPDPPPAATPVMPKPSSLSADT 835
LL+ P+F +E P+ +++L P + PV +
Sbjct: 932 GLLDA------PRFP-EGPEEASSTLRRQPQEGIWVLTPPSGEGVSGPV--------TEH 976
Query: 836 AALSHARLRSNSIGARHSTPRPLDAGRGRRLGGPRDPAPEKS-------RASSSGGSGGG 888
+ +L ++G R S P RGR + A K+ RA SG
Sbjct: 977 SGEQRPKLDEEAVG-RSSGSSPAMETRGRGTSQLAEGATAKAISDLAVRRARHRLLSGDS 1035
Query: 889 SGGR-------VPKSASVSALSLIITADDGSGGPLMSPLSPRSLSSNPSSRDSSPSRDPS 941
+ R V KSAS +ALSL+I ++ + PL SP+SP S SSNPSSRDSSPSRD
Sbjct: 1036 TEKRTARPVNKVIKSASATALSLLIPSEHHTCSPLASPMSPHSQSSNPSSRDSSPSRDFL 1095
Query: 942 PVCGSLRPPIVIHSSGKKYGFSLRAIRVYMGDSDVYTVHHVVWSVEDGSPAQEAGLRAGD 1001
P GS+RPPI+IH +GKKYGF+LRAIRVYMGDSDVYTVHH+VW VEDG PA EAGLR GD
Sbjct: 1096 PALGSMRPPIIIHRAGKKYGFTLRAIRVYMGDSDVYTVHHMVWHVEDGGPASEAGLRQGD 1155
Query: 1002 LITHINGESVLGLVHMDVVELLLKSGNKISLRTTALENTSIKVGPARKNVAKGRMARRSK 1061
LITH+NGE V GLVH +VVEL+LKSGNK+++ TT LENTSIKVGPARK K +MARRSK
Sbjct: 1156 LITHVNGEPVHGLVHTEVVELILKSGNKVAISTTPLENTSIKVGPARKGSYKAKMARRSK 1215
Query: 1062 RSRRRETQDRRK--SLFKKISKQTSVLHTSRSFSSGLHHSLSSSESLPGSPTHSLSPSPT 1119
RSR ++ Q+ RK SLF+KI+KQ S+LHTSRS SS L+ SLSS ES PGSPTHS S SP
Sbjct: 1216 RSRGKDGQESRKRSSLFRKITKQASLLHTSRSLSS-LNRSLSSGESGPGSPTHSHSLSPR 1274
Query: 1120 TPCRS--PAPD-VPADTTASPPSASPSSSSPASPAAAGHTRPSSLHGLAAKLGPPRPKTG 1176
+P + PD V + S S+SPSSS P+SPA +GHTRPSSLHGLA KL + ++
Sbjct: 1275 SPTQGYRVTPDAVHSVGGNSSQSSSPSSSVPSSPAGSGHTRPSSLHGLAPKL-QRQYRSP 1333
Query: 1177 RRKSTSSIPPSPLA----CPPISAPPPRSPSPLPGH------------PP---------- 1210
RRKS SIP SPLA PP +A P RSPSPL GH PP
Sbjct: 1334 RRKSAGSIPLSPLAHTPSPPPPTASPQRSPSPLSGHVAQAFPTKLHLSPPLGRQLSRPKS 1393
Query: 1211 -APARSPRLRRGQSADKL-----------------------------------------G 1228
P RSP L+R QSA+KL G
Sbjct: 1394 AEPPRSPLLKRVQSAEKLAAALAASEKKLATSRKHSLDLPHSELKKELPPREVSPLEVVG 1453
Query: 1229 TGERLDGEAGRRTRG-----PEAELVVMRRLHLSERRDSFKKQEAVQEV-SFDEPQEEAT 1282
L G+ +G P L +R+ +ERR+S +KQEA++EV S ++ EE
Sbjct: 1454 ARSVLSGKGALPGKGVLQPAPSRALGTLRQ-DRAERRESLQKQEAIREVDSSEDDTEEGP 1512
Query: 1283 GLPTSVPQIAVEGEEAVPVALGPTG 1307
++++ V ++ P G
Sbjct: 1513 ENSQGAQELSLAPHPEVSQSVAPKG 1537
>gi|45120119 microtubule associated serine/threonine kinase 1 [Homo
sapiens]
Length = 1570
Score = 1421 bits (3679), Expect = 0.0
Identities = 804/1357 (59%), Positives = 958/1357 (70%), Gaps = 105/1357 (7%)
Query: 17 SLPRRGRGCRSGNRKSLVVGTPSPTLSRPLSPLSVPTAGSSPLDSPRNFSAASALNFPFA 76
S+ RR + CR+ NRKSL++ + SPTL RP SPL GSSPLDSPRNFS + +F FA
Sbjct: 21 SMFRRTKSCRTSNRKSLILTSTSPTLPRPHSPLP-GHLGSSPLDSPRNFSPNTPAHFSFA 79
Query: 77 --RRADGRRWSLASLPSSGYGTNTPSSTLSSSSSSRERLHQLPFQPTPDELHFLSKHFRS 134
RRADGRRWSLASLPSSGYGTNTPSST+SSS SS+ERLHQLP+QPT DELHFLSKHF S
Sbjct: 80 SSRRADGRRWSLASLPSSGYGTNTPSSTVSSSCSSQERLHQLPYQPTVDELHFLSKHFGS 139
Query: 135 SENVLDEEGGR-SPRLRPRSRSLSPGRATGTFDNEIVMMNHVYRERFPKATAQMEGRLQE 193
+E++ DE+GGR SP +RPRSRSLSPGR+ ++DNEIVMMNHVY+ERFPKATAQME +L++
Sbjct: 140 TESITDEDGGRRSPAVRPRSRSLSPGRSPSSYDNEIVMMNHVYKERFPKATAQMEEKLRD 199
Query: 194 FLTAYAPGARLALADGVLGFIHHQIVELARDCLAKSGENLVTSRYFLEMQEKLERLLQDA 253
F AY P + L LADGVL FIHHQI+ELARDCL KS + L+T+ YF E+QE LE+LLQDA
Sbjct: 200 FTRAYEPDSVLPLADGVLSFIHHQIIELARDCLTKSRDGLITTVYFYELQENLEKLLQDA 259
Query: 254 HERSDSEEVSFIVQLVRKLLIIISRPARLLECLEFDPEEFYHLLEAAEGHAREGQGIKTD 313
+ERS+S EV+F+ QLV+KLLIIISRPARLLECLEF+PEEFYHLLEAAEGHA+EG +KTD
Sbjct: 260 YERSESLEVAFVTQLVKKLLIIISRPARLLECLEFNPEEFYHLLEAAEGHAKEGHLVKTD 319
Query: 314 LPQYIIGQLGLAKDPLEEMVPLSHLEEEQPPAPESPE----SRALVGQSRRKPCESDFET 369
+P+YII QLGL +DP ++V HLEE+ +PE S ++++ P E+DF+T
Sbjct: 320 IPRYIIRQLGLTRDPFPDVV---HLEEQDSGGSNTPEQDDLSEGRSSKAKKPPGENDFDT 376
Query: 370 IKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILTFAENPFVVS 429
IKLISNGAYGAVYLVRHRDTRQRFA+KKINKQNLILRNQIQQ FVERDILTFAENPFVV
Sbjct: 377 IKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVG 436
Query: 430 MFCSFETRRHLCMVMEYVEGGDCATLLKNMGPLPVDMARLYFAETVLALEYLHNYGIVHR 489
MFCSFETRRHLCMVMEYVEGGDCATLLKN+G LPV+MAR+YFAETVLALEYLHNYGIVHR
Sbjct: 437 MFCSFETRRHLCMVMEYVEGGDCATLLKNIGALPVEMARMYFAETVLALEYLHNYGIVHR 496
Query: 490 DLKPDNLLITSLGHIKLTDFGLSKIGLMSMATNLYEGHIEKDAREFIDKQVCGTPEYIAP 549
DLKPDNLLITS+GHIKLTDFGLSK+GLMS+ TNLYEGHIEKDAREF+DKQVCGTPEYIAP
Sbjct: 497 DLKPDNLLITSMGHIKLTDFGLSKMGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAP 556
Query: 550 EVIFRQGYGKPVDWWAMGVVLYEFLVGCVPFFGDTPEELFGQVVSDEIMWPEGDEALPAD 609
EVI RQGYGKPVDWWAMG++LYEFLVGCVPFFGDTPEELFGQV+SD+I+WPEGDEALP +
Sbjct: 557 EVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDDILWPEGDEALPTE 616
Query: 610 AQDLITRLLRQSPLDRLGTGGTHEVKQHPFFLALDWAGLLRHKAEFVPQLEAEDDTSYFD 669
AQ LI+ LL+ +PL RLG GG EVKQH FF LDW GLLR KAEF+P LE+EDDTSYFD
Sbjct: 617 AQLLISSLLQTNPLVRLGAGGAFEVKQHSFFRDLDWTGLLRQKAEFIPHLESEDDTSYFD 676
Query: 670 TRSERYRHLGSEDDETNDEESSTEIPQFSSCSHRFSKVYSSSEFLAVQPTPTFAERSFSE 729
TRS+RY H+ S D++ EE EI QFSSCS RFSKVYSS E L+ T + S
Sbjct: 677 TRSDRYHHVNSYDEDDTTEEEPVEIRQFSSCSPRFSKVYSSMEQLSQHEPKTPVAAAGSS 736
Query: 730 DREEGWERSEVDY-GRRL---SADIRLRSWTSSG------SSCQSSSSQPERGPSPSLLN 779
RE + E G+R +R ++W S+ ++S + E P
Sbjct: 737 KREPSTKGPEEKVAGKREGLGGLTLREKTWRGGSPEIKRFSASEASFLEGEASPPLGARR 796
Query: 780 TISLDTMP-KFAFSSEDEGVGPGPAGPKRPVFILGEPDPPPAATPVMPKPSSLSADTAAL 838
S P +F+ EDE A +RP P P++ P SL A
Sbjct: 797 RFSALLEPSRFSAPQEDE----DEARLRRP--------PRPSSDPA----GSLDARAPKE 840
Query: 839 SHARLRSNSIGARHST--PRPLD---AGRGRRLGGPR---DPAPEKSRASSSGGS----- 885
++S G +T PRP D + GPR D ++R G
Sbjct: 841 ETQGEGTSSAGDSEATDRPRPGDLCPPSKDGDASGPRATNDLVLRRARHQQMSGDVAVEK 900
Query: 886 -GGGSGGRVPKSASVSALSLIITADDGSG-GPLMSPLSPRSLSSNPSSRDSSPSRDPSPV 943
+GG+V KSAS +ALS++I A D G PL SP+SPRSLSSNPSSRDSSPSRD SP
Sbjct: 901 RPSRTGGKVIKSASATALSVMIPAVDPHGSSPLASPMSPRSLSSNPSSRDSSPSRDYSPA 960
Query: 944 CGSLRPPIVIHSSGKKYGFSLRAIRVYMGDSDVYTVHHVVWSVEDGSPAQEAGLRAGDLI 1003
LR PI I SGKKYGF+LRAIRVYMGD+DVY+VHH+VW VE+G PAQEAGL AGDLI
Sbjct: 961 VSGLRSPITIQRSGKKYGFTLRAIRVYMGDTDVYSVHHIVWHVEEGGPAQEAGLCAGDLI 1020
Query: 1004 THINGESVLGLVHMDVVELLLKSGNKISLRTTALENTSIKVGPARKNVAKGRMARRSKRS 1063
TH+NGE V G+VH +VVEL+LKSGNK+++ TT ENTSI++GPAR++ K +MARR+KR
Sbjct: 1021 THVNGEPVHGMVHPEVVELILKSGNKVAVTTTPFENTSIRIGPARRSSYKAKMARRNKRP 1080
Query: 1064 RRRETQD--RRKSLFKKISKQTSVLHTSRSFSSGLHHSLSSSESLPGSPTHSL-SPSPTT 1120
+E Q+ +R SLF+KI+KQ+++LHTSRS SS L+ SLSSS+SLPGSPTH L + SPT
Sbjct: 1081 SAKEGQESKKRSSLFRKITKQSNLLHTSRSLSS-LNRSLSSSDSLPGSPTHGLPARSPTH 1139
Query: 1121 PCRSPAPDVPADTTASPPSASPSSSSPASPA--AAGHTRPSSLHGLAAKLGPPRPKTGRR 1178
RS PD A AS S+SP+SS+P SPA A+ H RPS+LHGL+ KL + ++ R
Sbjct: 1140 SYRS-TPD-SAYLGASSQSSSPASSTPNSPASSASHHIRPSTLHGLSPKL-HRQYRSARC 1196
Query: 1179 KSTSSIPPSPLACPPISAPPPRSPSPLPGH------------------PPA--------- 1211
KS +IP SPLA P +P SP PLPGH PP
Sbjct: 1197 KSAGNIPLSPLAHTP--SPTQASPPPLPGHTVGSSHTTQSFPAKLHSSPPVVRPRPKSAE 1254
Query: 1212 PARSPRLRRGQSADKLGTGERLDGEAGRRTRGPEAELVVMRRLHLSERRDSFKK--QEAV 1269
P RSP L+R QSA+KLG D + R E H R+D + ++
Sbjct: 1255 PPRSPLLKRVQSAEKLGASLSADKKGALRKHSLEVG-------HPDFRKDFHGELALHSL 1307
Query: 1270 QEVSFDEPQEEATGLPTSVPQIAVE--GEEAVPVALG 1304
E + P E G P Q+AV G + P++LG
Sbjct: 1308 AESDGETPPVEGLGAPR---QVAVRRLGRQESPLSLG 1341
Score = 37.4 bits (85), Expect = 0.095
Identities = 33/104 (31%), Positives = 46/104 (44%), Gaps = 23/104 (22%)
Query: 1099 SLSSSESLPGSPTHSLSPSPTTPCRSPAPDVPADTTASPPSASPSSSSPASPAAAGHTRP 1158
+LS S P SP LSP P TP +PA S PS++ + PAS +G T+P
Sbjct: 1490 TLSGPRSKPASP--KLSPEPQTPSLAPAK-------CSAPSSAVTPVPPASLLGSG-TKP 1539
Query: 1159 SSLHGLAAKLGPPRPKTGRRKSTSSIPPSPLACPPISAPPPRSP 1202
GL + R ++PP+ L +S+P P P
Sbjct: 1540 QV--GLTS-----------RCPAEAVPPAGLTKKGVSSPAPPGP 1570
>gi|4502023 AKT2 kinase [Homo sapiens]
Length = 481
Score = 231 bits (589), Expect = 3e-60
Identities = 133/363 (36%), Positives = 198/363 (54%), Gaps = 37/363 (10%)
Query: 350 ESRALVGQSRRKPCESDFETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQI 409
E V ++R K +DF+ +KL+ G +G V LVR + T + +A+K + K+ +I ++++
Sbjct: 135 EMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEV 194
Query: 410 QQVFVERDILTFAENPFVVSMFCSFETRRHLCMVMEYVEGGDCATLLKNMGPLPVDMARL 469
E +L +PF+ ++ +F+T LC VMEY GG+ L + AR
Sbjct: 195 AHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARF 254
Query: 470 YFAETVLALEYLHNYGIVHRDLKPDNLLITSLGHIKLTDFGLSKIGLMSMATNLYEGHIE 529
Y AE V ALEYLH+ +V+RD+K +NL++ GHIK+TDFGL K G+ AT
Sbjct: 255 YGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATM------- 307
Query: 530 KDAREFIDKQVCGTPEYIAPEVIFRQGYGKPVDWWAMGVVLYEFLVGCVPFFGDTPEELF 589
K CGTPEY+APEV+ YG+ VDWW +GVV+YE + G +PF+ E LF
Sbjct: 308 --------KTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLF 359
Query: 590 GQVVSDEIMWPEGDEALPADAQDLITRLLRQSPLDRLGTG--GTHEVKQHPFFLALDWAG 647
++ +EI +P L +A+ L+ LL++ P RLG G EV +H FFL+++W
Sbjct: 360 ELILMEEIRFP---RTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQD 416
Query: 648 LLRHK--AEFVPQLEAEDDTSYFD----------TRSERYRHLGSEDDETNDEESSTEIP 695
+++ K F PQ+ +E DT YFD T +RY LG + + T P
Sbjct: 417 VVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLG-----LLELDQRTHFP 471
Query: 696 QFS 698
QFS
Sbjct: 472 QFS 474
>gi|24307971 serine/threonine kinase 38 like [Homo sapiens]
Length = 464
Score = 230 bits (586), Expect = 8e-60
Identities = 121/326 (37%), Positives = 189/326 (57%), Gaps = 24/326 (7%)
Query: 366 DFETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILTFAENP 425
DFE++K+I GA+G V LV+ +DT +A+K + K +++ + Q+ + ERDIL A+
Sbjct: 89 DFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDMLEKEQVAHIRAERDILVEADGA 148
Query: 426 FVVSMFCSFETRRHLCMVMEYVEGGDCATLLKNMGPLPVDMARLYFAETVLALEYLHNYG 485
+VV MF SF+ +R+L ++ME++ GGD TLL L + + Y +ETVLA++ +H G
Sbjct: 149 WVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYISETVLAIDAIHQLG 208
Query: 486 IVHRDLKPDNLLITSLGHIKLTDFGLSKIGLMSMATNLY--------------------E 525
+HRD+KPDNLL+ + GH+KL+DFGL + T Y +
Sbjct: 209 FIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTEFYRNLTHNPPSDFSFQNMNSKRK 268
Query: 526 GHIEKDAREFIDKQVCGTPEYIAPEVIFRQGYGKPVDWWAMGVVLYEFLVGCVPFFGDTP 585
K R + GTP+YIAPEV + GY K DWW++GV++YE L+G PF +TP
Sbjct: 269 AETWKKNRRQLAYSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETP 328
Query: 586 EELFGQVVS--DEIMWPEGDEALPADAQDLITRLLRQSPLDRLGTGGTHEVKQHPFFLAL 643
+E + +V++ + +++P + + A+DLI R S +R+G G E+K HPFF +
Sbjct: 329 QETYRKVMNWKETLVFPP-EVPISEKAKDLILRFCIDSE-NRIGNSGVEEIKGHPFFEGV 386
Query: 644 DWAGLLRHKAEFVPQLEAEDDTSYFD 669
DW + A ++++ DDTS FD
Sbjct: 387 DWEHIRERPAAIPIEIKSIDDTSNFD 412
>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
Length = 479
Score = 224 bits (571), Expect = 4e-58
Identities = 130/348 (37%), Positives = 190/348 (54%), Gaps = 35/348 (10%)
Query: 365 SDFETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILTFAEN 424
+DF+ +KL+ G +G V LVR + + + +A+K + K+ +I ++++ E +L +
Sbjct: 146 NDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRH 205
Query: 425 PFVVSMFCSFETRRHLCMVMEYVEGGDCATLLKNMGPLPVDMARLYFAETVLALEYLHNY 484
PF+ S+ SF+T+ LC VMEYV GG+ L D R Y AE V AL+YLH+
Sbjct: 206 PFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSG 265
Query: 485 GIVHRDLKPDNLLITSLGHIKLTDFGLSKIGLMSMATNLYEGHIEKDAREFIDKQVCGTP 544
IV+RDLK +NL++ GHIK+TDFGL K G+ AT K CGTP
Sbjct: 266 KIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATM---------------KTFCGTP 310
Query: 545 EYIAPEVIFRQGYGKPVDWWAMGVVLYEFLVGCVPFFGDTPEELFGQVVSDEIMWPEGDE 604
EY+APEV+ YG+ VDWW +GVV+YE + G +PF+ E+LF ++ ++I +P
Sbjct: 311 EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFP---R 367
Query: 605 ALPADAQDLITRLLRQSPLDRLGTG--GTHEVKQHPFFLALDWAGLLRHK--AEFVPQLE 660
L +DA+ L++ LL + P RLG G E+ +H FF ++W + K F PQ+
Sbjct: 368 TLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVT 427
Query: 661 AEDDTSYFD----------TRSERYRHLGSEDDETNDEESSTEIPQFS 698
+E DT YFD T E+Y G + D E PQFS
Sbjct: 428 SETDTRYFDEEFTAQTITITPPEKYDEDGM---DCMDNERRPHFPQFS 472
>gi|62241015 AKT1 kinase [Homo sapiens]
Length = 480
Score = 223 bits (568), Expect = 9e-58
Identities = 136/386 (35%), Positives = 202/386 (52%), Gaps = 31/386 (8%)
Query: 323 GLAKDPLEEMVPLSHLEEEQPPAPESPESRALVGQSRRKPCESDFETIKLISNGAYGAVY 382
GL K EEM S + A E S A + + + ++FE +KL+ G +G V
Sbjct: 109 GLKKQEEEEMDFRSGSPSDNSGAEEMEVSLA---KPKHRVTMNEFEYLKLLGKGTFGKVI 165
Query: 383 LVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILTFAENPFVVSMFCSFETRRHLCM 442
LV+ + T + +A+K + K+ ++ ++++ E +L + +PF+ ++ SF+T LC
Sbjct: 166 LVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCF 225
Query: 443 VMEYVEGGDCATLLKNMGPLPVDMARLYFAETVLALEYLHN-YGIVHRDLKPDNLLITSL 501
VMEY GG+ L D AR Y AE V AL+YLH+ +V+RDLK +NL++
Sbjct: 226 VMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKD 285
Query: 502 GHIKLTDFGLSKIGLMSMATNLYEGHIEKDAREFIDKQVCGTPEYIAPEVIFRQGYGKPV 561
GHIK+TDFGL K G+ AT K CGTPEY+APEV+ YG+ V
Sbjct: 286 GHIKITDFGLCKEGIKDGATM---------------KTFCGTPEYLAPEVLEDNDYGRAV 330
Query: 562 DWWAMGVVLYEFLVGCVPFFGDTPEELFGQVVSDEIMWPEGDEALPADAQDLITRLLRQS 621
DWW +GVV+YE + G +PF+ E+LF ++ +EI +P L +A+ L++ LL++
Sbjct: 331 DWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP---RTLGPEAKSLLSGLLKKD 387
Query: 622 PLDRLGTGG--THEVKQHPFFLALDWAGLLRHKAE--FVPQLEAEDDTSYFDTRSERYRH 677
P RLG G E+ QH FF + W + K F PQ+ +E DT YFD
Sbjct: 388 PKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMI 447
Query: 678 LGSEDDETN-----DEESSTEIPQFS 698
+ D+ + D E PQFS
Sbjct: 448 TITPPDQDDSMECVDSERRPHFPQFS 473
>gi|62241013 AKT1 kinase [Homo sapiens]
Length = 480
Score = 223 bits (568), Expect = 9e-58
Identities = 136/386 (35%), Positives = 202/386 (52%), Gaps = 31/386 (8%)
Query: 323 GLAKDPLEEMVPLSHLEEEQPPAPESPESRALVGQSRRKPCESDFETIKLISNGAYGAVY 382
GL K EEM S + A E S A + + + ++FE +KL+ G +G V
Sbjct: 109 GLKKQEEEEMDFRSGSPSDNSGAEEMEVSLA---KPKHRVTMNEFEYLKLLGKGTFGKVI 165
Query: 383 LVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILTFAENPFVVSMFCSFETRRHLCM 442
LV+ + T + +A+K + K+ ++ ++++ E +L + +PF+ ++ SF+T LC
Sbjct: 166 LVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCF 225
Query: 443 VMEYVEGGDCATLLKNMGPLPVDMARLYFAETVLALEYLHN-YGIVHRDLKPDNLLITSL 501
VMEY GG+ L D AR Y AE V AL+YLH+ +V+RDLK +NL++
Sbjct: 226 VMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKD 285
Query: 502 GHIKLTDFGLSKIGLMSMATNLYEGHIEKDAREFIDKQVCGTPEYIAPEVIFRQGYGKPV 561
GHIK+TDFGL K G+ AT K CGTPEY+APEV+ YG+ V
Sbjct: 286 GHIKITDFGLCKEGIKDGATM---------------KTFCGTPEYLAPEVLEDNDYGRAV 330
Query: 562 DWWAMGVVLYEFLVGCVPFFGDTPEELFGQVVSDEIMWPEGDEALPADAQDLITRLLRQS 621
DWW +GVV+YE + G +PF+ E+LF ++ +EI +P L +A+ L++ LL++
Sbjct: 331 DWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP---RTLGPEAKSLLSGLLKKD 387
Query: 622 PLDRLGTGG--THEVKQHPFFLALDWAGLLRHKAE--FVPQLEAEDDTSYFDTRSERYRH 677
P RLG G E+ QH FF + W + K F PQ+ +E DT YFD
Sbjct: 388 PKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMI 447
Query: 678 LGSEDDETN-----DEESSTEIPQFS 698
+ D+ + D E PQFS
Sbjct: 448 TITPPDQDDSMECVDSERRPHFPQFS 473
>gi|62241011 AKT1 kinase [Homo sapiens]
Length = 480
Score = 223 bits (568), Expect = 9e-58
Identities = 136/386 (35%), Positives = 202/386 (52%), Gaps = 31/386 (8%)
Query: 323 GLAKDPLEEMVPLSHLEEEQPPAPESPESRALVGQSRRKPCESDFETIKLISNGAYGAVY 382
GL K EEM S + A E S A + + + ++FE +KL+ G +G V
Sbjct: 109 GLKKQEEEEMDFRSGSPSDNSGAEEMEVSLA---KPKHRVTMNEFEYLKLLGKGTFGKVI 165
Query: 383 LVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILTFAENPFVVSMFCSFETRRHLCM 442
LV+ + T + +A+K + K+ ++ ++++ E +L + +PF+ ++ SF+T LC
Sbjct: 166 LVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCF 225
Query: 443 VMEYVEGGDCATLLKNMGPLPVDMARLYFAETVLALEYLHN-YGIVHRDLKPDNLLITSL 501
VMEY GG+ L D AR Y AE V AL+YLH+ +V+RDLK +NL++
Sbjct: 226 VMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKD 285
Query: 502 GHIKLTDFGLSKIGLMSMATNLYEGHIEKDAREFIDKQVCGTPEYIAPEVIFRQGYGKPV 561
GHIK+TDFGL K G+ AT K CGTPEY+APEV+ YG+ V
Sbjct: 286 GHIKITDFGLCKEGIKDGATM---------------KTFCGTPEYLAPEVLEDNDYGRAV 330
Query: 562 DWWAMGVVLYEFLVGCVPFFGDTPEELFGQVVSDEIMWPEGDEALPADAQDLITRLLRQS 621
DWW +GVV+YE + G +PF+ E+LF ++ +EI +P L +A+ L++ LL++
Sbjct: 331 DWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP---RTLGPEAKSLLSGLLKKD 387
Query: 622 PLDRLGTGG--THEVKQHPFFLALDWAGLLRHKAE--FVPQLEAEDDTSYFDTRSERYRH 677
P RLG G E+ QH FF + W + K F PQ+ +E DT YFD
Sbjct: 388 PKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMI 447
Query: 678 LGSEDDETN-----DEESSTEIPQFS 698
+ D+ + D E PQFS
Sbjct: 448 TITPPDQDDSMECVDSERRPHFPQFS 473
>gi|5453976 protein kinase C, theta [Homo sapiens]
Length = 706
Score = 221 bits (563), Expect = 4e-57
Identities = 127/348 (36%), Positives = 197/348 (56%), Gaps = 33/348 (9%)
Query: 326 KDPLEEMVPLSHLEEEQPPAPESPESRALVGQSRRKPCESDFETIKLISNGAYGAVYLVR 385
+ PL+E+ + HL P PE + R + + K DF K++ G++G V+L
Sbjct: 347 ESPLDEVDKMCHL-----PEPELNKERPSL---QIKLKIEDFILHKMLGKGSFGKVFLAE 398
Query: 386 HRDTRQRFAIKKINKQNLILRNQIQQVFVERDILTFA-ENPFVVSMFCSFETRRHLCMVM 444
+ T Q FAIK + K +++ + ++ VE+ +L+ A E+PF+ MFC+F+T+ +L VM
Sbjct: 399 FKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVM 458
Query: 445 EYVEGGDCATLLKNMGPLPVDMARLYFAETVLALEYLHNYGIVHRDLKPDNLLITSLGHI 504
EY+ GGD +++ + A Y AE +L L++LH+ GIV+RDLK DN+L+ GHI
Sbjct: 459 EYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHI 518
Query: 505 KLTDFGLSKIGLMSMA-TNLYEGHIEKDAREFIDKQVCGTPEYIAPEVIFRQGYGKPVDW 563
K+ DFG+ K ++ A TN + CGTP+YIAPE++ Q Y VDW
Sbjct: 519 KIADFGMCKENMLGDAKTNTF----------------CGTPDYIAPEILLGQKYNHSVDW 562
Query: 564 WAMGVVLYEFLVGCVPFFGDTPEELFGQVVSDEIMWPEGDEALPADAQDLITRLLRQSPL 623
W+ GV+LYE L+G PF G EELF + D +P L +A+DL+ +L + P
Sbjct: 563 WSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRW---LEKEAKDLLVKLFVREPE 619
Query: 624 DRLGTGGTHEVKQHPFFLALDWAGLLRHKAE--FVPQLEAEDDTSYFD 669
RLG G +++QHP F ++W L R + + F P++++ D S FD
Sbjct: 620 KRLGVRG--DIRQHPLFREINWEELERKEIDPPFRPKVKSPFDCSNFD 665
>gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Homo
sapiens]
Length = 1551
Score = 221 bits (563), Expect = 4e-57
Identities = 134/364 (36%), Positives = 201/364 (55%), Gaps = 29/364 (7%)
Query: 366 DFETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILTFAENP 425
DFE +K+I GA+G V +VR RDT Q FA+K ++K ++ R + ERD+L ++
Sbjct: 70 DFEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREERDVLVKGDSR 129
Query: 426 FVVSMFCSFETRRHLCMVMEYVEGGDCATLLKNM-GPLPVDMARLYFAETVLALEYLHNY 484
+V ++ +F+ +L +VM+Y GGD TLL LP ++A+ Y AE VLA+ LH
Sbjct: 130 WVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMVLAIHSLHQL 189
Query: 485 GIVHRDLKPDNLLITSLGHIKLTDFGLSKIGLMSMATNLYEGHIEKDAREFIDKQVC-GT 543
G VHRD+KPDN+L+ GHI+L DFG + + TN +D V GT
Sbjct: 190 GYVHRDVKPDNVLLDVNGHIRLADFG----SCLRLNTN-----------GMVDSSVAVGT 234
Query: 544 PEYIAPEVI--FRQG---YGKPVDWWAMGVVLYEFLVGCVPFFGDTPEELFGQVVS--DE 596
P+YI+PE++ +G YG DWW++GV YE L G PF+ ++ E +G++++ D
Sbjct: 235 PDYISPEILQAMEEGKGHYGPQCDWWSLGVCAYELLFGETPFYAESLVETYGKIMNHEDH 294
Query: 597 IMWPEGDEALPADAQDLITRLL-RQSPLDRLGTGGTHEVKQHPFFLALDWAGLLRHKAEF 655
+ +P +PA AQDLI +LL RQ +RLG GG + + HPFF +DW L A +
Sbjct: 295 LQFPPDVPDVPASAQDLIRQLLCRQE--ERLGRGGLDDFRNHPFFEGVDWERLASSTAPY 352
Query: 656 VPQLEAEDDTSYFDTRSERYRHLGSEDDETNDEESSTEIP--QFSSCSHRFSKVYSSSEF 713
+P+L DTS FD + H G+ ++ S +P F+ S S SS +
Sbjct: 353 IPELRGPMDTSNFDVDDDTLNHPGTLPPPSHGAFSGHHLPFVGFTYTSGSHSPESSSEAW 412
Query: 714 LAVQ 717
A++
Sbjct: 413 AALE 416
Score = 37.4 bits (85), Expect = 0.095
Identities = 32/109 (29%), Positives = 45/109 (41%), Gaps = 7/109 (6%)
Query: 838 LSHARLRSNSIGARHSTPRPLDAGRGRRLGGPRDP---APEKSRASSSGGSG-GGSGGRV 893
L H + GAR +P P + GR R GP+ P + R +S G G GG +
Sbjct: 1446 LVHVGPANGRPGARDKSPAPEEKGRVARGSGPQRPHSFSEALRRPASMGSEGLGGDADPM 1505
Query: 894 PKSASVSALSLIITADDGSGGPLMSPLSPRSLSSNPSSRDSSPSRDPSP 942
+ S S ++ GS P S + +S P S SP + SP
Sbjct: 1506 KRKPWTSLSSESVSCPQGSLSPATSLM---QVSERPRSLPLSPELESSP 1551
>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
Length = 465
Score = 221 bits (562), Expect = 5e-57
Identities = 120/309 (38%), Positives = 178/309 (57%), Gaps = 22/309 (7%)
Query: 365 SDFETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILTFAEN 424
+DF+ +KL+ G +G V LVR + + + +A+K + K+ +I ++++ E +L +
Sbjct: 146 NDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRH 205
Query: 425 PFVVSMFCSFETRRHLCMVMEYVEGGDCATLLKNMGPLPVDMARLYFAETVLALEYLHNY 484
PF+ S+ SF+T+ LC VMEYV GG+ L D R Y AE V AL+YLH+
Sbjct: 206 PFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSG 265
Query: 485 GIVHRDLKPDNLLITSLGHIKLTDFGLSKIGLMSMATNLYEGHIEKDAREFIDKQVCGTP 544
IV+RDLK +NL++ GHIK+TDFGL K G+ AT K CGTP
Sbjct: 266 KIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATM---------------KTFCGTP 310
Query: 545 EYIAPEVIFRQGYGKPVDWWAMGVVLYEFLVGCVPFFGDTPEELFGQVVSDEIMWPEGDE 604
EY+APEV+ YG+ VDWW +GVV+YE + G +PF+ E+LF ++ ++I +P
Sbjct: 311 EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFP---R 367
Query: 605 ALPADAQDLITRLLRQSPLDRLGTG--GTHEVKQHPFFLALDWAGLLRHK--AEFVPQLE 660
L +DA+ L++ LL + P RLG G E+ +H FF ++W + K F PQ+
Sbjct: 368 TLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVT 427
Query: 661 AEDDTSYFD 669
+E DT YFD
Sbjct: 428 SETDTRYFD 436
>gi|6005814 serine/threonine kinase 38 [Homo sapiens]
Length = 465
Score = 219 bits (559), Expect = 1e-56
Identities = 127/365 (34%), Positives = 199/365 (54%), Gaps = 25/365 (6%)
Query: 329 LEEMVPLSHLEEEQPPAPESPESRALVGQSRRKPCE---SDFETIKLISNGAYGAVYLVR 385
LE+++ L++E+ S +R R K DFE++K+I GA+G V LV+
Sbjct: 48 LEKVMEEEGLKDEEKRLRRSAHARKETEFLRLKRTRLGLEDFESLKVIGRGAFGEVRLVQ 107
Query: 386 HRDTRQRFAIKKINKQNLILRNQIQQVFVERDILTFAENPFVVSMFCSFETRRHLCMVME 445
+DT +A+K + K +++ + Q+ + ERDIL A++ +VV MF SF+ + +L ++ME
Sbjct: 108 KKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADSLWVVKMFYSFQDKLNLYLIME 167
Query: 446 YVEGGDCATLLKNMGPLPVDMARLYFAETVLALEYLHNYGIVHRDLKPDNLLITSLGHIK 505
++ GGD TLL L + + Y AETVLA++ +H G +HRD+KPDNLL+ S GH+K
Sbjct: 168 FLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVK 227
Query: 506 LTDFGLSKIGLMSMATNLY--------------------EGHIEKDAREFIDKQVCGTPE 545
L+DFGL + T Y + K R + GTP+
Sbjct: 228 LSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSKRKAETWKRNRRQLAFSTVGTPD 287
Query: 546 YIAPEVIFRQGYGKPVDWWAMGVVLYEFLVGCVPFFGDTPEELFGQVVS-DEIMWPEGDE 604
YIAPEV + GY K DWW++GV++YE L+G PF +TP+E + +V++ E + +
Sbjct: 288 YIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYKKVMNWKETLTFPPEV 347
Query: 605 ALPADAQDLITRLLRQSPLDRLGTGGTHEVKQHPFFLALDWAGLLRHKAEFVPQLEAEDD 664
+ A+DLI R + R+G G E+K + FF +DW + A ++++ DD
Sbjct: 348 PISEKAKDLILRFCCEWE-HRIGAPGVEEIKSNSFFEGVDWEHIRERPAAISIEIKSIDD 406
Query: 665 TSYFD 669
TS FD
Sbjct: 407 TSNFD 411
>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
[Homo sapiens]
Length = 1354
Score = 219 bits (557), Expect = 2e-56
Identities = 128/316 (40%), Positives = 186/316 (58%), Gaps = 25/316 (7%)
Query: 366 DFETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILTFAENP 425
D+E +K+I GA+G V LVRH+ TR+ +A+K ++K +I R+ + ERDI+ FA +P
Sbjct: 75 DYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSP 134
Query: 426 FVVSMFCSFETRRHLCMVMEYVEGGDCATLLKNMGPLPVDMARLYFAETVLALEYLHNYG 485
+VV +F +F+ R+L MVMEY+ GGD L+ N +P AR Y AE VLAL+ +H+ G
Sbjct: 135 WVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNY-DVPEKWARFYTAEVVLALDAIHSMG 193
Query: 486 IVHRDLKPDNLLITSLGHIKLTDFGLSKIGLMSMATNLYEGHIEKDAREFIDKQVCGTPE 545
+HRD+KPDN+L+ GH+KL DFG M N EG + D GTP+
Sbjct: 194 FIHRDVKPDNMLLDKSGHLKLADFG------TCMKMN-KEGMVRCDT-------AVGTPD 239
Query: 546 YIAPEVIFRQG----YGKPVDWWAMGVVLYEFLVGCVPFFGDTPEELFGQVVS--DEIMW 599
YI+PEV+ QG YG+ DWW++GV LYE LVG PF+ D+ + ++++ + + +
Sbjct: 240 YISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTF 299
Query: 600 PEGDEALPADAQDLITRLLRQSPLDRLGTGGTHEVKQHPFFLALDWA--GLLRHKAEFVP 657
P+ D + +A++LI L + RLG G E+K+H FF WA L A VP
Sbjct: 300 PD-DNDISKEAKNLICAFLTDREV-RLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVP 357
Query: 658 QLEAEDDTSYFDTRSE 673
L ++ DTS FD E
Sbjct: 358 DLSSDIDTSNFDDLEE 373
>gi|126091095 myotonic dystrophy protein kinase isoform 1 [Homo
sapiens]
Length = 639
Score = 218 bits (556), Expect = 2e-56
Identities = 126/352 (35%), Positives = 189/352 (53%), Gaps = 26/352 (7%)
Query: 345 APESPESRALVGQSRRKPCE-SDFETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNL 403
+P +P + +V + + + DFE +K+I GA+ V +V+ + T Q +A+K +NK ++
Sbjct: 58 SPTTPPAEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDM 117
Query: 404 ILRNQIQQVFVERDILTFAENPFVVSMFCSFETRRHLCMVMEYVEGGDCATLLKNMGP-L 462
+ R ++ ERD+L + ++ + +F+ +L +VMEY GGD TLL G +
Sbjct: 118 LKRGEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERI 177
Query: 463 PVDMARLYFAETVLALEYLHNYGIVHRDLKPDNLLITSLGHIKLTDFGLSKIGLMSMATN 522
P +MAR Y AE V+A++ +H G VHRD+KPDN+L+ GHI+L DFG S + L + T
Sbjct: 178 PAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFG-SCLKLRADGT- 235
Query: 523 LYEGHIEKDAREFIDKQVCGTPEYIAPEVIFRQG-------YGKPVDWWAMGVVLYEFLV 575
R + GTP+Y++PE++ G YG DWWA+GV YE
Sbjct: 236 ---------VRSLV---AVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFY 283
Query: 576 GCVPFFGDTPEELFGQVV--SDEIMWPEGDEALPADAQDLITRLLRQSPLDRLGTGGTHE 633
G PF+ D+ E +G++V + + P DE +P +A+D I RLL P RLG GG +
Sbjct: 284 GQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLL-CPPETRLGRGGAGD 342
Query: 634 VKQHPFFLALDWAGLLRHKAEFVPQLEAEDDTSYFDTRSERYRHLGSEDDET 685
+ HPFF LDW GL F P E DT FD + + S ET
Sbjct: 343 FRTHPFFFGLDWDGLRDSVPPFTPDFEGATDTCNFDLVEDGLTAMVSGGGET 394
>gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform a [Homo sapiens]
Length = 733
Score = 218 bits (554), Expect = 4e-56
Identities = 125/342 (36%), Positives = 193/342 (56%), Gaps = 28/342 (8%)
Query: 335 LSHLEEEQPPAPESPESRALVGQSRRKPCESDFETIKLISNGAYGAVYLVRH---RDTRQ 391
LS LEEE G + P S FE +K++ G+YG V+LVR D Q
Sbjct: 29 LSRLEEEGVVKEIDISHHVKEGFEKADP--SQFELLKVLGQGSYGKVFLVRKVKGSDAGQ 86
Query: 392 RFAIKKINKQNLILRNQIQQVFVERDILTFAENPFVVSMFCSFETRRHLCMVMEYVEGGD 451
+A+K + K L +R++++ +ERDIL +PF+V + +F+T L ++++++ GGD
Sbjct: 87 LYAMKVLKKATLKVRDRVRSK-MERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGD 145
Query: 452 CATLLKNMGPLPVDMARLYFAETVLALEYLHNYGIVHRDLKPDNLLITSLGHIKLTDFGL 511
T L + + Y AE LAL++LH+ GI++RDLKP+N+L+ GHIK+TDFGL
Sbjct: 146 LFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGL 205
Query: 512 SKIGLMSMATNLYEGHIEKDAREFIDKQVCGTPEYIAPEVIFRQGYGKPVDWWAMGVVLY 571
SK I+ D R + CGT EY+APEV+ R+G+ + DWW+ GV+++
Sbjct: 206 SKEA------------IDHDKRAY---SFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMF 250
Query: 572 EFLVGCVPFFGDTPEELFGQVVSDEIMWPEGDEALPADAQDLITRLLRQSPLDRLGTG-- 629
E L G +PF G +E ++ ++ P + L +AQ L+ L +++P +RLG G
Sbjct: 251 EMLTGSLPFQGKDRKETMALILKAKLGMP---QFLSGEAQSLLRALFKRNPCNRLGAGID 307
Query: 630 GTHEVKQHPFFLALDWAGLLRH--KAEFVPQLEAEDDTSYFD 669
G E+K+HPFF+ +DW L R K F P + +DT +FD
Sbjct: 308 GVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFD 349
Score = 105 bits (262), Expect = 3e-22
Identities = 74/281 (26%), Positives = 136/281 (48%), Gaps = 32/281 (11%)
Query: 367 FETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILTFAENPF 426
+E + I G+Y H+ T +A+K I+K R+ +++ + +L + ++P
Sbjct: 415 YEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSK---RDPSEEIEI---LLRYGQHPN 468
Query: 427 VVSMFCSFETRRHLCMVMEYVEGGDCATLLKNMGPLPVDMARLYFAETVLALEYLHNYGI 486
++++ ++ + + +VME + GG+ + A ++YLH+ G+
Sbjct: 469 IITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGV 528
Query: 487 VHRDLKPDNLLIT----SLGHIKLTDFGLSKIGLMSMATNLYEGHIEKDAREFIDKQVCG 542
VHRDLKP N+L S I++ DFG +K + A + C
Sbjct: 529 VHRDLKPSNILYRDESGSPESIRVCDFGFAK---------------QLRAGNGLLMTPCY 573
Query: 543 TPEYIAPEVIFRQGYGKPVDWWAMGVVLYEFLVGCVPFFG---DTPEELFGQVVSDEIMW 599
T ++APEV+ RQGY D W++G++LY L G PF DTPEE+ ++ S +
Sbjct: 574 TANFVAPEVLKRQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYAL 633
Query: 600 PEGD-EALPADAQDLITRLLRQSPLDRLGTGGTHEVKQHPF 639
G+ +++ A+D+++++L P RL +V +HP+
Sbjct: 634 SGGNWDSISDAAKDVVSKMLHVDPHQRL---TAMQVLKHPW 671
>gi|47059024 myotonic dystrophy protein kinase isoform 2 [Homo
sapiens]
Length = 629
Score = 217 bits (553), Expect = 5e-56
Identities = 123/330 (37%), Positives = 179/330 (54%), Gaps = 25/330 (7%)
Query: 366 DFETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILTFAENP 425
DFE +K+I GA+ V +V+ + T Q +A+K +NK +++ R ++ ERD+L +
Sbjct: 70 DFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDRR 129
Query: 426 FVVSMFCSFETRRHLCMVMEYVEGGDCATLLKNMGP-LPVDMARLYFAETVLALEYLHNY 484
++ + +F+ +L +VMEY GGD TLL G +P +MAR Y AE V+A++ +H
Sbjct: 130 WITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHRL 189
Query: 485 GIVHRDLKPDNLLITSLGHIKLTDFGLSKIGLMSMATNLYEGHIEKDAREFIDKQVCGTP 544
G VHRD+KPDN+L+ GHI+L DFG S + L + T R + GTP
Sbjct: 190 GYVHRDIKPDNILLDRCGHIRLADFG-SCLKLRADGT----------VRSLV---AVGTP 235
Query: 545 EYIAPEVIFRQG-------YGKPVDWWAMGVVLYEFLVGCVPFFGDTPEELFGQVV--SD 595
+Y++PE++ G YG DWWA+GV YE G PF+ D+ E +G++V +
Sbjct: 236 DYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKE 295
Query: 596 EIMWPEGDEALPADAQDLITRLLRQSPLDRLGTGGTHEVKQHPFFLALDWAGLLRHKAEF 655
+ P DE +P +A+D I RLL P RLG GG + + HPFF LDW GL F
Sbjct: 296 HLSLPLVDEGVPEEARDFIQRLL-CPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPF 354
Query: 656 VPQLEAEDDTSYFDTRSERYRHLGSEDDET 685
P E DT FD + + S ET
Sbjct: 355 TPDFEGATDTCNFDLVEDGLTAMVSGGGET 384
>gi|126091040 myotonic dystrophy protein kinase isoform 4 [Homo
sapiens]
Length = 625
Score = 217 bits (552), Expect = 7e-56
Identities = 120/314 (38%), Positives = 174/314 (55%), Gaps = 25/314 (7%)
Query: 366 DFETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILTFAENP 425
DFE +K+I GA+ V +V+ + T Q +A+K +NK +++ R ++ ERD+L +
Sbjct: 70 DFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDRR 129
Query: 426 FVVSMFCSFETRRHLCMVMEYVEGGDCATLLKNMGP-LPVDMARLYFAETVLALEYLHNY 484
++ + +F+ +L +VMEY GGD TLL G +P +MAR Y AE V+A++ +H
Sbjct: 130 WITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHRL 189
Query: 485 GIVHRDLKPDNLLITSLGHIKLTDFGLSKIGLMSMATNLYEGHIEKDAREFIDKQVCGTP 544
G VHRD+KPDN+L+ GHI+L DFG S + L + T R + GTP
Sbjct: 190 GYVHRDIKPDNILLDRCGHIRLADFG-SCLKLRADGT----------VRSLV---AVGTP 235
Query: 545 EYIAPEVIFRQG-------YGKPVDWWAMGVVLYEFLVGCVPFFGDTPEELFGQVV--SD 595
+Y++PE++ G YG DWWA+GV YE G PF+ D+ E +G++V +
Sbjct: 236 DYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKE 295
Query: 596 EIMWPEGDEALPADAQDLITRLLRQSPLDRLGTGGTHEVKQHPFFLALDWAGLLRHKAEF 655
+ P DE +P +A+D I RLL P RLG GG + + HPFF LDW GL F
Sbjct: 296 HLSLPLVDEGVPEEARDFIQRLL-CPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPF 354
Query: 656 VPQLEAEDDTSYFD 669
P E DT FD
Sbjct: 355 TPDFEGATDTCNFD 368
>gi|126131093 myotonic dystrophy protein kinase isoform 3 [Homo
sapiens]
Length = 624
Score = 217 bits (552), Expect = 7e-56
Identities = 120/314 (38%), Positives = 174/314 (55%), Gaps = 25/314 (7%)
Query: 366 DFETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILTFAENP 425
DFE +K+I GA+ V +V+ + T Q +A+K +NK +++ R ++ ERD+L +
Sbjct: 70 DFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDRR 129
Query: 426 FVVSMFCSFETRRHLCMVMEYVEGGDCATLLKNMGP-LPVDMARLYFAETVLALEYLHNY 484
++ + +F+ +L +VMEY GGD TLL G +P +MAR Y AE V+A++ +H
Sbjct: 130 WITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHRL 189
Query: 485 GIVHRDLKPDNLLITSLGHIKLTDFGLSKIGLMSMATNLYEGHIEKDAREFIDKQVCGTP 544
G VHRD+KPDN+L+ GHI+L DFG S + L + T R + GTP
Sbjct: 190 GYVHRDIKPDNILLDRCGHIRLADFG-SCLKLRADGT----------VRSLV---AVGTP 235
Query: 545 EYIAPEVIFRQG-------YGKPVDWWAMGVVLYEFLVGCVPFFGDTPEELFGQVV--SD 595
+Y++PE++ G YG DWWA+GV YE G PF+ D+ E +G++V +
Sbjct: 236 DYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKE 295
Query: 596 EIMWPEGDEALPADAQDLITRLLRQSPLDRLGTGGTHEVKQHPFFLALDWAGLLRHKAEF 655
+ P DE +P +A+D I RLL P RLG GG + + HPFF LDW GL F
Sbjct: 296 HLSLPLVDEGVPEEARDFIQRLL-CPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPF 354
Query: 656 VPQLEAEDDTSYFD 669
P E DT FD
Sbjct: 355 TPDFEGATDTCNFD 368
>gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform b [Homo sapiens]
Length = 741
Score = 216 bits (551), Expect = 9e-56
Identities = 124/338 (36%), Positives = 193/338 (57%), Gaps = 27/338 (7%)
Query: 339 EEEQPPAPESPESRALVGQSRRKPCESDFETIKLISNGAYGAVYLVRH---RDTRQRFAI 395
EEE+ E S V + K S FE +K++ G+YG V+LVR D Q +A+
Sbjct: 40 EEEEGVVKEIDISHH-VKEGFEKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAM 98
Query: 396 KKINKQNLILRNQIQQVFVERDILTFAENPFVVSMFCSFETRRHLCMVMEYVEGGDCATL 455
K + K L +R++++ +ERDIL +PF+V + +F+T L ++++++ GGD T
Sbjct: 99 KVLKKATLKVRDRVRSK-MERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTR 157
Query: 456 LKNMGPLPVDMARLYFAETVLALEYLHNYGIVHRDLKPDNLLITSLGHIKLTDFGLSKIG 515
L + + Y AE LAL++LH+ GI++RDLKP+N+L+ GHIK+TDFGLSK
Sbjct: 158 LSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEA 217
Query: 516 LMSMATNLYEGHIEKDAREFIDKQVCGTPEYIAPEVIFRQGYGKPVDWWAMGVVLYEFLV 575
I+ D R + CGT EY+APEV+ R+G+ + DWW+ GV+++E L
Sbjct: 218 ------------IDHDKRAY---SFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLT 262
Query: 576 GCVPFFGDTPEELFGQVVSDEIMWPEGDEALPADAQDLITRLLRQSPLDRLGTG--GTHE 633
G +PF G +E ++ ++ P + L +AQ L+ L +++P +RLG G G E
Sbjct: 263 GSLPFQGKDRKETMALILKAKLGMP---QFLSGEAQSLLRALFKRNPCNRLGAGIDGVEE 319
Query: 634 VKQHPFFLALDWAGLLRH--KAEFVPQLEAEDDTSYFD 669
+K+HPFF+ +DW L R K F P + +DT +FD
Sbjct: 320 IKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFD 357
Score = 105 bits (262), Expect = 3e-22
Identities = 74/281 (26%), Positives = 136/281 (48%), Gaps = 32/281 (11%)
Query: 367 FETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILTFAENPF 426
+E + I G+Y H+ T +A+K I+K R+ +++ + +L + ++P
Sbjct: 423 YEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSK---RDPSEEIEI---LLRYGQHPN 476
Query: 427 VVSMFCSFETRRHLCMVMEYVEGGDCATLLKNMGPLPVDMARLYFAETVLALEYLHNYGI 486
++++ ++ + + +VME + GG+ + A ++YLH+ G+
Sbjct: 477 IITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGV 536
Query: 487 VHRDLKPDNLLIT----SLGHIKLTDFGLSKIGLMSMATNLYEGHIEKDAREFIDKQVCG 542
VHRDLKP N+L S I++ DFG +K + A + C
Sbjct: 537 VHRDLKPSNILYRDESGSPESIRVCDFGFAK---------------QLRAGNGLLMTPCY 581
Query: 543 TPEYIAPEVIFRQGYGKPVDWWAMGVVLYEFLVGCVPFFG---DTPEELFGQVVSDEIMW 599
T ++APEV+ RQGY D W++G++LY L G PF DTPEE+ ++ S +
Sbjct: 582 TANFVAPEVLKRQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYAL 641
Query: 600 PEGD-EALPADAQDLITRLLRQSPLDRLGTGGTHEVKQHPF 639
G+ +++ A+D+++++L P RL +V +HP+
Sbjct: 642 SGGNWDSISDAAKDVVSKMLHVDPHQRL---TAMQVLKHPW 679
>gi|5453974 protein kinase N2 [Homo sapiens]
Length = 984
Score = 216 bits (549), Expect = 1e-55
Identities = 116/311 (37%), Positives = 180/311 (57%), Gaps = 26/311 (8%)
Query: 366 DFETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDI---LTFA 422
DF ++ G +G V L +++T + FAIK + K +++ R+++ + E+ I +
Sbjct: 656 DFRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSV 715
Query: 423 ENPFVVSMFCSFETRRHLCMVMEYVEGGDCATLLKNMGPLPVDMARLYFAETVLALEYLH 482
+PF+V++F F+T+ H+C VMEY GGD + + A Y A VL L+YLH
Sbjct: 716 RHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHI-HTDVFSEPRAVFYAACVVLGLQYLH 774
Query: 483 NYGIVHRDLKPDNLLITSLGHIKLTDFGLSKIGLMSMATNLYEGHIEKDAREFIDKQVCG 542
+ IV+RDLK DNLL+ + G +K+ DFGL K G+ G+ ++ + CG
Sbjct: 775 EHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGM---------GYGDRTST------FCG 819
Query: 543 TPEYIAPEVIFRQGYGKPVDWWAMGVVLYEFLVGCVPFFGDTPEELFGQVVSDEIMWPEG 602
TPE++APEV+ Y + VDWW +GV++YE LVG PF GD EE+F +V+DE+ +P
Sbjct: 820 TPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYP-- 877
Query: 603 DEALPADAQDLITRLLRQSPLDRLGTG--GTHEVKQHPFFLALDWAGLLRHKAE--FVPQ 658
L +A ++ RLLR++P RLG +VK+HPFF +DW+ L+ K + F+P
Sbjct: 878 -RFLSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPT 936
Query: 659 LEAEDDTSYFD 669
+ +D S FD
Sbjct: 937 IRGREDVSNFD 947
>gi|28557781 protein kinase C, eta [Homo sapiens]
Length = 683
Score = 215 bits (547), Expect = 3e-55
Identities = 122/348 (35%), Positives = 190/348 (54%), Gaps = 26/348 (7%)
Query: 328 PLEEMVPLSHLEEEQPPAPESPESRALVGQSRRKPCESDFETIKLISNGAYGAVYLVRHR 387
P ++V S L + + S E + S + +FE I+++ G++G V L R +
Sbjct: 318 PTSKLVSRSTLRRQGKES--SKEGNGIGVNSSNRLGIDNFEFIRVLGKGSFGKVMLARVK 375
Query: 388 DTRQRFAIKKINKQNLILRNQIQQVFVERDILTFAEN-PFVVSMFCSFETRRHLCMVMEY 446
+T +A+K + K ++ + ++ E+ IL+ A N PF+ +FC F+T L VME+
Sbjct: 376 ETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEF 435
Query: 447 VEGGDCATLLKNMGPLPVDMARLYFAETVLALEYLHNYGIVHRDLKPDNLLITSLGHIKL 506
V GGD ++ AR Y AE + AL +LH+ GI++RDLK DN+L+ GH KL
Sbjct: 436 VNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLDHEGHCKL 495
Query: 507 TDFGLSKIGLMSMATNLYEGHIEKDAREFIDKQVCGTPEYIAPEVIFRQGYGKPVDWWAM 566
DFG+ K G+ + T CGTP+YIAPE++ YG VDWWAM
Sbjct: 496 ADFGMCKEGICNGVTT---------------ATFCGTPDYIAPEILQEMLYGPAVDWWAM 540
Query: 567 GVVLYEFLVGCVPFFGDTPEELFGQVVSDEIMWPEGDEALPADAQDLITRLLRQSPLDRL 626
GV+LYE L G PF + ++LF +++DE+++P L DA ++ + ++P RL
Sbjct: 541 GVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTW---LHEDATGILKSFMTKNPTMRL 597
Query: 627 GT---GGTHEVKQHPFFLALDWAGLLRHKAE--FVPQLEAEDDTSYFD 669
G+ GG H + +HPFF +DWA L + E F P++++ +D S FD
Sbjct: 598 GSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFD 645
>gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo
sapiens]
Length = 740
Score = 214 bits (546), Expect = 3e-55
Identities = 124/343 (36%), Positives = 192/343 (55%), Gaps = 31/343 (9%)
Query: 339 EEEQPPAPESPESRAL-----VGQSRRKPCESDFETIKLISNGAYGAVYLVRH---RDTR 390
EEE P E + + V + K S FE +K++ G++G V+LV+ D R
Sbjct: 35 EEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDAR 94
Query: 391 QRFAIKKINKQNLILRNQIQQVFVERDILTFAENPFVVSMFCSFETRRHLCMVMEYVEGG 450
Q +A+K + K L +R++++ +ERDIL +PF+V + +F+T L ++++++ GG
Sbjct: 95 QLYAMKVLKKATLKVRDRVRTK-MERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGG 153
Query: 451 DCATLLKNMGPLPVDMARLYFAETVLALEYLHNYGIVHRDLKPDNLLITSLGHIKLTDFG 510
D T L + + Y AE LAL++LH+ GI++RDLKP+N+L+ GHIKLTDFG
Sbjct: 154 DLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFG 213
Query: 511 LSKIGLMSMATNLYEGHIEKDAREFIDKQVCGTPEYIAPEVIFRQGYGKPVDWWAMGVVL 570
LSK + EK A F CGT EY+APEV+ R+G+ + DWW+ GV++
Sbjct: 214 LSKESI----------DHEKKAYSF-----CGTVEYMAPEVVNRRGHTQSADWWSFGVLM 258
Query: 571 YEFLVGCVPFFGDTPEELFGQVVSDEIMWPEGDEALPADAQDLITRLLRQSPLDRLGTG- 629
+E L G +PF G +E ++ ++ P + L +AQ L+ L +++P +RLG G
Sbjct: 259 FEMLTGTLPFQGKDRKETMTMILKAKLGMP---QFLSPEAQSLLRMLFKRNPANRLGAGP 315
Query: 630 -GTHEVKQHPFFLALDWAGLLRHKAE--FVPQLEAEDDTSYFD 669
G E+K+H FF +DW L R + F P +DT YFD
Sbjct: 316 DGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFD 358
Score = 108 bits (270), Expect = 3e-23
Identities = 82/315 (26%), Positives = 149/315 (47%), Gaps = 34/315 (10%)
Query: 340 EEQPPAPESPESRALVGQSRRKPCE--SDFETIKLISNGAYGAVYLVRHRDTRQRFAIKK 397
+++ A ++ ++V Q R + +E + I G+Y H+ T FA+K
Sbjct: 393 DDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKI 452
Query: 398 INKQNLILRNQIQQVFVERDILTFAENPFVVSMFCSFETRRHLCMVMEYVEGGDCATLLK 457
I+K R+ +++ + +L + ++P ++++ ++ +++ +V E ++GG+ +
Sbjct: 453 IDKSK---RDPTEEIEI---LLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKIL 506
Query: 458 NMGPLPVDMARLYFAETVLALEYLHNYGIVHRDLKPDNLL-ITSLGH---IKLTDFGLSK 513
A +EYLH G+VHRDLKP N+L + G+ I++ DFG +K
Sbjct: 507 RQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAK 566
Query: 514 IGLMSMATNLYEGHIEKDAREFIDKQVCGTPEYIAPEVIFRQGYGKPVDWWAMGVVLYEF 573
+ A + C T ++APEV+ RQGY D W++GV+LY
Sbjct: 567 ---------------QLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTM 611
Query: 574 LVGCVPFFG---DTPEELFGQVVSDEIMWPEGD-EALPADAQDLITRLLRQSPLDRLGTG 629
L G PF DTPEE+ ++ S + G ++ A+DL++++L P RL
Sbjct: 612 LTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAA 671
Query: 630 GTHEVKQHPFFLALD 644
V +HP+ + D
Sbjct: 672 ---LVLRHPWIVHWD 683
>gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]
Length = 745
Score = 214 bits (546), Expect = 3e-55
Identities = 118/320 (36%), Positives = 186/320 (58%), Gaps = 24/320 (7%)
Query: 355 VGQSRRKPCESDFETIKLISNGAYGAVYLVRHR---DTRQRFAIKKINKQNLILRNQIQQ 411
V + K + FE +K++ G++G V+LVR + D Q +A+K + K +L +R++++
Sbjct: 61 VKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRT 120
Query: 412 VFVERDILTFAENPFVVSMFCSFETRRHLCMVMEYVEGGDCATLLKNMGPLPVDMARLYF 471
+ERDIL +PF+V + +F+T L ++++++ GGD T L + + Y
Sbjct: 121 K-MERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYL 179
Query: 472 AETVLALEYLHNYGIVHRDLKPDNLLITSLGHIKLTDFGLSKIGLMSMATNLYEGHIEKD 531
AE LAL++LH GIV+RDLKP+N+L+ +GHIKLTDFGLSK + EK
Sbjct: 180 AELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQ----------EKK 229
Query: 532 AREFIDKQVCGTPEYIAPEVIFRQGYGKPVDWWAMGVVLYEFLVGCVPFFGDTPEELFGQ 591
A F CGT EY+APEV+ R+G+ + DWW+ GV+++E L G +PF G E
Sbjct: 230 AYSF-----CGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNM 284
Query: 592 VVSDEIMWPEGDEALPADAQDLITRLLRQSPLDRLGTGGTHEVKQHPFFLALDWAGLLRH 651
++ ++ P + L A+AQ L+ L +++P +RLG+ G E+K+H FF +DW L +
Sbjct: 285 ILKAKLGMP---QFLSAEAQSLLRMLFKRNPANRLGSEGVEEIKRHLFFANIDWDKLYKR 341
Query: 652 KAE--FVPQLEAEDDTSYFD 669
+ + F P DDT FD
Sbjct: 342 EVQPPFKPASGKPDDTFCFD 361
Score = 97.1 bits (240), Expect = 1e-19
Identities = 68/267 (25%), Positives = 124/267 (46%), Gaps = 29/267 (10%)
Query: 367 FETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILTFAENPF 426
+E + I G+Y H T FA+K I+K R+ +++ + ++ + ++P
Sbjct: 426 YELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSK---RDPSEEIEI---LMRYGQHPN 479
Query: 427 VVSMFCSFETRRHLCMVMEYVEGGDCATLLKNMGPLPVDMARLYFAETVLALEYLHNYGI 486
++++ F+ R++ +V + ++GG+ + A ++YLH G+
Sbjct: 480 IITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGV 539
Query: 487 VHRDLKPDNLLI----TSLGHIKLTDFGLSKIGLMSMATNLYEGHIEKDAREFIDKQVCG 542
VHRDLKP N+L S I++ DFG +K + + C
Sbjct: 540 VHRDLKPSNILYMDESASADSIRICDFGFAK---------------QLRGENGLLLTPCY 584
Query: 543 TPEYIAPEVIFRQGYGKPVDWWAMGVVLYEFLVGCVPFF---GDTPEELFGQVVSDEIMW 599
T ++APEV+ +QGY D W++GV+ Y L G PF DTPEE+ ++ + +
Sbjct: 585 TANFVAPEVLMQQGYDAACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSL 644
Query: 600 PEGD-EALPADAQDLITRLLRQSPLDR 625
G+ + + A+DL++ +L P R
Sbjct: 645 SGGNWDNISDGAKDLLSHMLHMDPHQR 671
>gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform a [Homo sapiens]
Length = 735
Score = 213 bits (543), Expect = 7e-55
Identities = 131/364 (35%), Positives = 196/364 (53%), Gaps = 42/364 (11%)
Query: 328 PLEEMVPLSHLE-----EEQPPAPESPES---------RALVGQSRRKPCESDFETIKLI 373
PL E+VPL EE P E G + P S FE +K++
Sbjct: 11 PLMELVPLDPENGQTSGEEAGLQPSKDEGVLKEISITHHVKAGSEKADP--SHFELLKVL 68
Query: 374 SNGAYGAVYLVR---HRDTRQRFAIKKINKQNLILRNQIQQVFVERDILTFAENPFVVSM 430
G++G V+LVR D+ +A+K + K L +R++++ +ERDIL +PFVV +
Sbjct: 69 GQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTK-MERDILADVNHPFVVKL 127
Query: 431 FCSFETRRHLCMVMEYVEGGDCATLLKNMGPLPVDMARLYFAETVLALEYLHNYGIVHRD 490
+F+T L ++++++ GGD T L + + Y AE L L++LH+ GI++RD
Sbjct: 128 HYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRD 187
Query: 491 LKPDNLLITSLGHIKLTDFGLSKIGLMSMATNLYEGHIEKDAREFIDKQVCGTPEYIAPE 550
LKP+N+L+ GHIKLTDFGLSK + EK A F CGT EY+APE
Sbjct: 188 LKPENILLDEEGHIKLTDFGLSKEAI----------DHEKKAYSF-----CGTVEYMAPE 232
Query: 551 VIFRQGYGKPVDWWAMGVVLYEFLVGCVPFFGDTPEELFGQVVSDEIMWPEGDEALPADA 610
V+ RQG+ DWW+ GV+++E L G +PF G +E ++ ++ P + L +A
Sbjct: 233 VVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMP---QFLSTEA 289
Query: 611 QDLITRLLRQSPLDRLGTG--GTHEVKQHPFFLALDWAGLLRH--KAEFVPQLEAEDDTS 666
Q L+ L +++P +RLG+G G E+K+H F+ +DW L R K F P + DDT
Sbjct: 290 QSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTF 349
Query: 667 YFDT 670
YFDT
Sbjct: 350 YFDT 353
Score = 114 bits (286), Expect = 5e-25
Identities = 83/315 (26%), Positives = 150/315 (47%), Gaps = 33/315 (10%)
Query: 339 EEEQPPAPESPESRALVGQSRRKPCESDFETIK-LISNGAYGAVYLVRHRDTRQRFAIKK 397
++ +P AP++P + + SD +K I G+Y H+ T +A+K
Sbjct: 389 DDGKPRAPQAPLHSVVQQLHGKNLVFSDGYVVKETIGVGSYSECKRCVHKATNMEYAVKV 448
Query: 398 INKQNLILRNQIQQVFVERDILTFAENPFVVSMFCSFETRRHLCMVMEYVEGGDCATLLK 457
I+K R+ +++ + +L + ++P ++++ ++ +H+ +V E + GG+ +
Sbjct: 449 IDKSK---RDPSEEIEI---LLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKIL 502
Query: 458 NMGPLPVDMARLYFAETVLALEYLHNYGIVHRDLKPDNLL-ITSLGH---IKLTDFGLSK 513
A +EYLH+ G+VHRDLKP N+L + G+ +++ DFG +K
Sbjct: 503 RQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAK 562
Query: 514 IGLMSMATNLYEGHIEKDAREFIDKQVCGTPEYIAPEVIFRQGYGKPVDWWAMGVVLYEF 573
+ A + C T ++APEV+ RQGY + D W++G++LY
Sbjct: 563 ---------------QLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTM 607
Query: 574 LVGCVPFF---GDTPEELFGQVVSDEIMWPEGD-EALPADAQDLITRLLRQSPLDRLGTG 629
L G PF DTPEE+ ++ S + G+ + A+DL++++L P RL
Sbjct: 608 LAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRL--- 664
Query: 630 GTHEVKQHPFFLALD 644
+V QHP+ D
Sbjct: 665 TAKQVLQHPWVTQKD 679
>gi|41872583 Rho-associated, coiled-coil containing protein kinase 2
[Homo sapiens]
Length = 1388
Score = 213 bits (542), Expect = 1e-54
Identities = 119/316 (37%), Positives = 185/316 (58%), Gaps = 33/316 (10%)
Query: 366 DFETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILTFAENP 425
D++ +K+I GA+G V LVRH+ +++ +A+K ++K +I R+ + ERDI+ FA +P
Sbjct: 91 DYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSP 150
Query: 426 FVVSMFCSFETRRHLCMVMEYVEGGDCATLLKNMGPLPVDMARLYFAETVLALEYLHNYG 485
+VV +F +F+ R+L MVMEY+ GGD L+ N +P A+ Y AE VLAL+ +H+ G
Sbjct: 151 WVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNY-DVPEKWAKFYTAEVVLALDAIHSMG 209
Query: 486 IVHRDLKPDNLLITSLGHIKLTDFG----LSKIGLMSMATNLYEGHIEKDAREFIDKQVC 541
++HRD+KPDN+L+ GH+KL DFG + + G++ T
Sbjct: 210 LIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDT------------------AV 251
Query: 542 GTPEYIAPEVIFRQG----YGKPVDWWAMGVVLYEFLVGCVPFFGDTPEELFGQVV--SD 595
GTP+YI+PEV+ QG YG+ DWW++GV LYE LVG PF+ D+ + +++ +
Sbjct: 252 GTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKN 311
Query: 596 EIMWPEGDEALPADAQDLITRLLRQSPLDRLGTGGTHEVKQHPFFL--ALDWAGLLRHKA 653
+ +PE D + A++LI L + RLG G E++QHPFF W + A
Sbjct: 312 SLCFPE-DAEISKHAKNLICAFLTDREV-RLGRNGVEEIRQHPFFKNDQWHWDNIRETAA 369
Query: 654 EFVPQLEAEDDTSYFD 669
VP+L ++ D+S FD
Sbjct: 370 PVVPELSSDIDSSNFD 385
>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform b [Homo sapiens]
Length = 744
Score = 213 bits (541), Expect = 1e-54
Identities = 119/313 (38%), Positives = 182/313 (58%), Gaps = 26/313 (8%)
Query: 365 SDFETIKLISNGAYGAVYLVR---HRDTRQRFAIKKINKQNLILRNQIQQVFVERDILTF 421
S FE +K++ G++G V+LVR D+ +A+K + K L +R++++ +ERDIL
Sbjct: 69 SHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTK-MERDILAD 127
Query: 422 AENPFVVSMFCSFETRRHLCMVMEYVEGGDCATLLKNMGPLPVDMARLYFAETVLALEYL 481
+PFVV + +F+T L ++++++ GGD T L + + Y AE L L++L
Sbjct: 128 VNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHL 187
Query: 482 HNYGIVHRDLKPDNLLITSLGHIKLTDFGLSKIGLMSMATNLYEGHIEKDAREFIDKQVC 541
H+ GI++RDLKP+N+L+ GHIKLTDFGLSK + EK A F C
Sbjct: 188 HSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAI----------DHEKKAYSF-----C 232
Query: 542 GTPEYIAPEVIFRQGYGKPVDWWAMGVVLYEFLVGCVPFFGDTPEELFGQVVSDEIMWPE 601
GT EY+APEV+ RQG+ DWW+ GV+++E L G +PF G +E ++ ++ P
Sbjct: 233 GTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMP- 291
Query: 602 GDEALPADAQDLITRLLRQSPLDRLGTG--GTHEVKQHPFFLALDWAGLLRH--KAEFVP 657
+ L +AQ L+ L +++P +RLG+G G E+K+H F+ +DW L R K F P
Sbjct: 292 --QFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKP 349
Query: 658 QLEAEDDTSYFDT 670
+ DDT YFDT
Sbjct: 350 AVAQPDDTFYFDT 362
Score = 114 bits (286), Expect = 5e-25
Identities = 83/315 (26%), Positives = 150/315 (47%), Gaps = 33/315 (10%)
Query: 339 EEEQPPAPESPESRALVGQSRRKPCESDFETIK-LISNGAYGAVYLVRHRDTRQRFAIKK 397
++ +P AP++P + + SD +K I G+Y H+ T +A+K
Sbjct: 398 DDGKPRAPQAPLHSVVQQLHGKNLVFSDGYVVKETIGVGSYSECKRCVHKATNMEYAVKV 457
Query: 398 INKQNLILRNQIQQVFVERDILTFAENPFVVSMFCSFETRRHLCMVMEYVEGGDCATLLK 457
I+K R+ +++ + +L + ++P ++++ ++ +H+ +V E + GG+ +
Sbjct: 458 IDKSK---RDPSEEIEI---LLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKIL 511
Query: 458 NMGPLPVDMARLYFAETVLALEYLHNYGIVHRDLKPDNLL-ITSLGH---IKLTDFGLSK 513
A +EYLH+ G+VHRDLKP N+L + G+ +++ DFG +K
Sbjct: 512 RQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAK 571
Query: 514 IGLMSMATNLYEGHIEKDAREFIDKQVCGTPEYIAPEVIFRQGYGKPVDWWAMGVVLYEF 573
+ A + C T ++APEV+ RQGY + D W++G++LY
Sbjct: 572 ---------------QLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTM 616
Query: 574 LVGCVPFF---GDTPEELFGQVVSDEIMWPEGD-EALPADAQDLITRLLRQSPLDRLGTG 629
L G PF DTPEE+ ++ S + G+ + A+DL++++L P RL
Sbjct: 617 LAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRL--- 673
Query: 630 GTHEVKQHPFFLALD 644
+V QHP+ D
Sbjct: 674 TAKQVLQHPWVTQKD 688
>gi|47132591 protein kinase N1 isoform 1 [Homo sapiens]
Length = 948
Score = 213 bits (541), Expect = 1e-54
Identities = 131/348 (37%), Positives = 192/348 (55%), Gaps = 33/348 (9%)
Query: 330 EEMVPLSHLEEEQPPAPESPESRALVGQSRRKPCE-SDFETIKLISNGAYGAVYLVRHRD 388
E P E ++ P P AL R+ P DF+ + ++ G +G V L R
Sbjct: 589 ESTAPELPSETQETPGP------ALCSPLRKSPLTLEDFKFLAVLGRGHFGKVLLSEFRP 642
Query: 389 TRQRFAIKKINKQNLILRNQIQQVFVERDIL---TFAENPFVVSMFCSFETRRHLCMVME 445
+ + FAIK + K +++ R++++ + E+ IL T A +PF+V++F F+T H+C VME
Sbjct: 643 SGELFAIKALKKGDIVARDEVESLMCEKRILAAVTSAGHPFLVNLFGCFQTPEHVCFVME 702
Query: 446 YVEGGDCATLLKNMGPLPVDMARLYFAETVLALEYLHNYGIVHRDLKPDNLLITSLGHIK 505
Y GGD + + A Y A VL L++LH + IV+RDLK DNLL+ + G++K
Sbjct: 703 YSAGGDLMLHIHS-DVFSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVK 761
Query: 506 LTDFGLSKIGLMSMATNLYEGHIEKDAREFIDKQVCGTPEYIAPEVIFRQGYGKPVDWWA 565
+ DFGL K G+ G+ ++ + CGTPE++APEV+ Y + VDWW
Sbjct: 762 IADFGLCKEGM---------GYGDRTST------FCGTPEFLAPEVLTDTSYTRAVDWWG 806
Query: 566 MGVVLYEFLVGCVPFFGDTPEELFGQVVSDEIMWPEGDEALPADAQDLITRLLRQSPLDR 625
+GV+LYE LVG PF GD EE+F +V+DE+ +P L A+A ++ RLLR++P R
Sbjct: 807 LGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYP---RFLSAEAIGIMRRLLRRNPERR 863
Query: 626 LGTG--GTHEVKQHPFFLALDWAGLL--RHKAEFVPQLEAEDDTSYFD 669
LG+ +VK+ PFF L W LL R FVP L D S FD
Sbjct: 864 LGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFD 911
>gi|47132589 protein kinase N1 isoform 2 [Homo sapiens]
Length = 942
Score = 213 bits (541), Expect = 1e-54
Identities = 131/348 (37%), Positives = 192/348 (55%), Gaps = 33/348 (9%)
Query: 330 EEMVPLSHLEEEQPPAPESPESRALVGQSRRKPCE-SDFETIKLISNGAYGAVYLVRHRD 388
E P E ++ P P AL R+ P DF+ + ++ G +G V L R
Sbjct: 583 ESTAPELPSETQETPGP------ALCSPLRKSPLTLEDFKFLAVLGRGHFGKVLLSEFRP 636
Query: 389 TRQRFAIKKINKQNLILRNQIQQVFVERDIL---TFAENPFVVSMFCSFETRRHLCMVME 445
+ + FAIK + K +++ R++++ + E+ IL T A +PF+V++F F+T H+C VME
Sbjct: 637 SGELFAIKALKKGDIVARDEVESLMCEKRILAAVTSAGHPFLVNLFGCFQTPEHVCFVME 696
Query: 446 YVEGGDCATLLKNMGPLPVDMARLYFAETVLALEYLHNYGIVHRDLKPDNLLITSLGHIK 505
Y GGD + + A Y A VL L++LH + IV+RDLK DNLL+ + G++K
Sbjct: 697 YSAGGDLMLHIHS-DVFSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVK 755
Query: 506 LTDFGLSKIGLMSMATNLYEGHIEKDAREFIDKQVCGTPEYIAPEVIFRQGYGKPVDWWA 565
+ DFGL K G+ G+ ++ + CGTPE++APEV+ Y + VDWW
Sbjct: 756 IADFGLCKEGM---------GYGDRTST------FCGTPEFLAPEVLTDTSYTRAVDWWG 800
Query: 566 MGVVLYEFLVGCVPFFGDTPEELFGQVVSDEIMWPEGDEALPADAQDLITRLLRQSPLDR 625
+GV+LYE LVG PF GD EE+F +V+DE+ +P L A+A ++ RLLR++P R
Sbjct: 801 LGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYP---RFLSAEAIGIMRRLLRRNPERR 857
Query: 626 LGTG--GTHEVKQHPFFLALDWAGLL--RHKAEFVPQLEAEDDTSYFD 669
LG+ +VK+ PFF L W LL R FVP L D S FD
Sbjct: 858 LGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFD 905
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.132 0.387
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 59,537,460
Number of Sequences: 37866
Number of extensions: 3538823
Number of successful extensions: 45255
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1084
Number of HSP's successfully gapped in prelim test: 1988
Number of HSP's that attempted gapping in prelim test: 21543
Number of HSP's gapped (non-prelim): 17007
length of query: 1309
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1195
effective length of database: 13,930,794
effective search space: 16647298830
effective search space used: 16647298830
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.