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Search of human proteins with 150170653
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|150170653 EF-hand calcium binding domain 4A [Homo sapiens]
(294 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|150170653 EF-hand calcium binding domain 4A [Homo sapiens] 577 e-165
gi|14249254 EF-hand calcium binding domain 4B isoform c [Homo sa... 142 3e-34
gi|222418793 EF-hand calcium binding domain 4B isoform b [Homo s... 142 3e-34
gi|222418791 EF-hand calcium binding domain 4B isoform a [Homo s... 142 3e-34
gi|40255119 RAS and EF-hand domain containing [Homo sapiens] 59 7e-09
gi|148746195 trichohyalin [Homo sapiens] 55 1e-07
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 49 7e-06
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 49 7e-06
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 49 7e-06
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 49 7e-06
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 49 7e-06
gi|56549694 enabled homolog isoform a [Homo sapiens] 47 3e-05
gi|39930375 enabled homolog isoform b [Homo sapiens] 47 3e-05
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 46 4e-05
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 46 4e-05
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 45 8e-05
gi|81295809 pericentrin [Homo sapiens] 45 8e-05
gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens] 44 1e-04
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 44 2e-04
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 44 2e-04
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 43 3e-04
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 43 3e-04
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 43 3e-04
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 43 3e-04
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 43 3e-04
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 43 3e-04
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 43 3e-04
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 43 3e-04
gi|78042577 MAP7 domain containing 1 [Homo sapiens] 43 3e-04
gi|38044112 restin isoform b [Homo sapiens] 43 4e-04
>gi|150170653 EF-hand calcium binding domain 4A [Homo sapiens]
Length = 294
Score = 577 bits (1487), Expect = e-165
Identities = 294/294 (100%), Positives = 294/294 (100%)
Query: 1 MASPGKPGADEAQEEEGELEGGSAGPRAAILEQAEELFLLCDKEAKGFITKHDLQGLQSD 60
MASPGKPGADEAQEEEGELEGGSAGPRAAILEQAEELFLLCDKEAKGFITKHDLQGLQSD
Sbjct: 1 MASPGKPGADEAQEEEGELEGGSAGPRAAILEQAEELFLLCDKEAKGFITKHDLQGLQSD 60
Query: 61 LPLTPEQLEAVFESLDRAHTGFLTAREFCLGLGMFVGVASAQGANPCRTPEETFESGGLD 120
LPLTPEQLEAVFESLDRAHTGFLTAREFCLGLGMFVGVASAQGANPCRTPEETFESGGLD
Sbjct: 61 LPLTPEQLEAVFESLDRAHTGFLTAREFCLGLGMFVGVASAQGANPCRTPEETFESGGLD 120
Query: 121 VQGTAGSLDEEEEEEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPELLGSFEDVLI 180
VQGTAGSLDEEEEEEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPELLGSFEDVLI
Sbjct: 121 VQGTAGSLDEEEEEEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPELLGSFEDVLI 180
Query: 181 RASACLEEAARERDGLEQALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRS 240
RASACLEEAARERDGLEQALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRS
Sbjct: 181 RASACLEEAARERDGLEQALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRS 240
Query: 241 RLELELQSREQDLERAGLRQRERRGRRLQEHAERESQPATATGAAQGAEYTAAG 294
RLELELQSREQDLERAGLRQRERRGRRLQEHAERESQPATATGAAQGAEYTAAG
Sbjct: 241 RLELELQSREQDLERAGLRQRERRGRRLQEHAERESQPATATGAAQGAEYTAAG 294
>gi|14249254 EF-hand calcium binding domain 4B isoform c [Homo
sapiens]
Length = 395
Score = 142 bits (359), Expect = 3e-34
Identities = 92/276 (33%), Positives = 153/276 (55%), Gaps = 14/276 (5%)
Query: 15 EEGELEGGSAGPRAAILEQAEELFLLCDKEAKGFITKHDLQGLQSDLPLTPEQLEAVFES 74
E+ E + ++G + +L +A+E F CD E KGFI + D+Q L +LPL+ E+LE VF++
Sbjct: 37 EQKETQEQTSG-QLVMLRKAQEFFQTCDAEGKGFIARKDMQRLHKELPLSLEELEDVFDA 95
Query: 75 LDRAHTGFLTAREFCLGLGMFVGVASAQGANPC------RTPEETFESGGLDVQGTAGSL 128
LD G+LT +EF G F + R E+ + S G + G G
Sbjct: 96 LDADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQRHEEKVYLSRGDEDLGDMG-- 153
Query: 129 DEEEEEEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPELLGSFEDVLIRASACLEE 188
E+EE +F ++++LG VL + V+ LW +L++E P LL +FED L R + L+E
Sbjct: 154 ---EDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQE 210
Query: 189 AARERDGLEQALRRRESEHEREVRALYEETE-QLREQSRRPPSQNFARGERRSR-LELEL 246
A E++ LE AL+R+ + ++ E++ LYEE E Q++ + + ++ R + RS+ LE +L
Sbjct: 211 AHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKL 270
Query: 247 QSREQDLERAGLRQRERRGRRLQEHAERESQPATAT 282
+EQ+LE+ +Q+ G+ H ++ A T
Sbjct: 271 LCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENT 306
>gi|222418793 EF-hand calcium binding domain 4B isoform b [Homo
sapiens]
Length = 462
Score = 142 bits (359), Expect = 3e-34
Identities = 92/276 (33%), Positives = 153/276 (55%), Gaps = 14/276 (5%)
Query: 15 EEGELEGGSAGPRAAILEQAEELFLLCDKEAKGFITKHDLQGLQSDLPLTPEQLEAVFES 74
E+ E + ++G + +L +A+E F CD E KGFI + D+Q L +LPL+ E+LE VF++
Sbjct: 37 EQKETQEQTSG-QLVMLRKAQEFFQTCDAEGKGFIARKDMQRLHKELPLSLEELEDVFDA 95
Query: 75 LDRAHTGFLTAREFCLGLGMFVGVASAQGANPC------RTPEETFESGGLDVQGTAGSL 128
LD G+LT +EF G F + R E+ + S G + G G
Sbjct: 96 LDADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQRHEEKVYLSRGDEDLGDMG-- 153
Query: 129 DEEEEEEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPELLGSFEDVLIRASACLEE 188
E+EE +F ++++LG VL + V+ LW +L++E P LL +FED L R + L+E
Sbjct: 154 ---EDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQE 210
Query: 189 AARERDGLEQALRRRESEHEREVRALYEETE-QLREQSRRPPSQNFARGERRSR-LELEL 246
A E++ LE AL+R+ + ++ E++ LYEE E Q++ + + ++ R + RS+ LE +L
Sbjct: 211 AHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKL 270
Query: 247 QSREQDLERAGLRQRERRGRRLQEHAERESQPATAT 282
+EQ+LE+ +Q+ G+ H ++ A T
Sbjct: 271 LCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENT 306
>gi|222418791 EF-hand calcium binding domain 4B isoform a [Homo
sapiens]
Length = 731
Score = 142 bits (359), Expect = 3e-34
Identities = 92/276 (33%), Positives = 153/276 (55%), Gaps = 14/276 (5%)
Query: 15 EEGELEGGSAGPRAAILEQAEELFLLCDKEAKGFITKHDLQGLQSDLPLTPEQLEAVFES 74
E+ E + ++G + +L +A+E F CD E KGFI + D+Q L +LPL+ E+LE VF++
Sbjct: 37 EQKETQEQTSG-QLVMLRKAQEFFQTCDAEGKGFIARKDMQRLHKELPLSLEELEDVFDA 95
Query: 75 LDRAHTGFLTAREFCLGLGMFVGVASAQGANPC------RTPEETFESGGLDVQGTAGSL 128
LD G+LT +EF G F + R E+ + S G + G G
Sbjct: 96 LDADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQRHEEKVYLSRGDEDLGDMG-- 153
Query: 129 DEEEEEEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPELLGSFEDVLIRASACLEE 188
E+EE +F ++++LG VL + V+ LW +L++E P LL +FED L R + L+E
Sbjct: 154 ---EDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQE 210
Query: 189 AARERDGLEQALRRRESEHEREVRALYEETE-QLREQSRRPPSQNFARGERRSR-LELEL 246
A E++ LE AL+R+ + ++ E++ LYEE E Q++ + + ++ R + RS+ LE +L
Sbjct: 211 AHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKL 270
Query: 247 QSREQDLERAGLRQRERRGRRLQEHAERESQPATAT 282
+EQ+LE+ +Q+ G+ H ++ A T
Sbjct: 271 LCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENT 306
>gi|40255119 RAS and EF-hand domain containing [Homo sapiens]
Length = 740
Score = 58.5 bits (140), Expect = 7e-09
Identities = 58/262 (22%), Positives = 109/262 (41%), Gaps = 21/262 (8%)
Query: 31 LEQAEELFLLCDKEAKGFITKHDLQGLQSDLPLTPEQLEAVFESLDRAHTGFLTAREFCL 90
L + +F CD G + + + + L ++L + P EAVF+ LD G +T +EF
Sbjct: 10 LARLRSVFAACDANRSGRLEREEFRALCTELRVRPADAEAVFQRLDADRDGAITFQEFAR 69
Query: 91 G-LGMFVG-----------VASAQGANPCRTPEETFESGGLDVQGTAGSLDEEEEEEERF 138
G LG G + A P T + + G D + +
Sbjct: 70 GFLGSLRGGRRRDWGPLDPAPAVSEAGP-ETHDSEEDEGDEDAAAALATSCGPASPGRAW 128
Query: 139 HTVLEQLG-VAPVLGKQRAVRTLWARLQRERPELLGSFEDVLIRASACLEEAARERDGLE 197
+LG A + ++ V TL+ + P L+ +E V+ + + E + L
Sbjct: 129 QDFQARLGDEAKFIPREEQVSTLYQNINLVEPRLIQPYEHVIKNFIREIRLQSTEMENLA 188
Query: 198 QALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRSRLELELQS--REQDLER 255
A++R + + ++ L EE +Q R +++ R + + + E L R+ + E
Sbjct: 189 IAVKRAQDKAAMQLSELEEEMDQ-----RIQAAEHKTRKDEKRKAEEALSDLRRQYETEV 243
Query: 256 AGLRQRERRGRRLQEHAERESQ 277
L+ ++ R+L+E ++R SQ
Sbjct: 244 GDLQVTIKKLRKLEEQSKRVSQ 265
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 54.7 bits (130), Expect = 1e-07
Identities = 42/152 (27%), Positives = 67/152 (44%), Gaps = 10/152 (6%)
Query: 126 GSLDEEEEEEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPELLGSFEDVLIRASAC 185
G +++++ ER V ++ ++ +R +LQ E P+ R
Sbjct: 222 GREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQ----------RQREL 271
Query: 186 LEEAARERDGLEQALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRSRLELE 245
EE + R Q LRR E E++ + L E + R+Q Q R E++ R E +
Sbjct: 272 QEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQ 331
Query: 246 LQSREQDLERAGLRQRERRGRRLQEHAERESQ 277
+ REQ L R +RE++ RR QE RE Q
Sbjct: 332 EERREQQLRREQEERREQQLRREQEEERREQQ 363
Score = 52.4 bits (124), Expect = 5e-07
Identities = 50/149 (33%), Positives = 71/149 (47%), Gaps = 12/149 (8%)
Query: 129 DEEEEEEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPELLGSFEDVLIRASACLEE 188
+EEE+E + TVL + L ++ R R +E E L E +R EE
Sbjct: 240 EEEEKEWRKRETVLRK--EEEKLQEEEPQRQ---RELQEEEEQLRKLERQELRRERQEEE 294
Query: 189 AARERDGLEQALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRSRLELELQS 248
++R EQ LRR++ E RE + E ++ REQ Q R E+ R E +L+
Sbjct: 295 QQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRR-EQEERREQQLR- 352
Query: 249 REQDLERAGLRQRERRGRRLQEHAERESQ 277
REQ+ ER RE++ RR QE RE Q
Sbjct: 353 REQEEER-----REQQLRREQEEERREQQ 376
Score = 48.1 bits (113), Expect = 9e-06
Identities = 46/149 (30%), Positives = 67/149 (44%), Gaps = 28/149 (18%)
Query: 129 DEEEEEEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPELLGSFEDVLIRASACLEE 188
DE ++EEE+ + E+ + ++R R LQ+E +LLG E
Sbjct: 1024 DELQQEEEQL--LREEREKRRLQERERQYREE-EELQQEEEQLLGE------------ER 1068
Query: 189 AARERDGLEQALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRSRLELELQS 248
R R LE+ R+ E + E + L EE E+ R Q R ER+ R E ELQ
Sbjct: 1069 ETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQER----------ERQCREEEELQQ 1118
Query: 249 REQDLERAGLRQRERRGRRLQEHAERESQ 277
E+ L R +RE+R R+ E RE +
Sbjct: 1119 EEEQLLR---EEREKRRRQELERQYREEE 1144
Score = 47.0 bits (110), Expect = 2e-05
Identities = 45/147 (30%), Positives = 68/147 (46%), Gaps = 7/147 (4%)
Query: 131 EEEEEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPELLGSFEDVLIRASACLEEAA 190
+EEE +R + E+ L +Q R R + E+ + E L R EE
Sbjct: 261 QEEEPQRQRELQEEEEQLRKLERQELRRE---RQEEEQQQQRLRREQQLRRKQE--EERR 315
Query: 191 RERDGLEQALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRSRLELELQSRE 250
+++ + RRE + ER + L E E+ REQ R Q R E++ R E E + RE
Sbjct: 316 EQQEERREQQERREQQEERREQQLRREQEERREQQLR-REQEEERREQQLRREQEEERRE 374
Query: 251 QDLERAGLRQRERRGRRLQEHAERESQ 277
Q L R +RE++ RR ++ RE Q
Sbjct: 375 QQLRREQQLRREQQLRR-EQQLRREQQ 400
Score = 47.0 bits (110), Expect = 2e-05
Identities = 47/164 (28%), Positives = 71/164 (43%), Gaps = 21/164 (12%)
Query: 132 EEEEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRE---------RPELLGSFEDVLIRA 182
E+EEER EQ L +++ R W + + E + +L E+
Sbjct: 428 EQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRER 487
Query: 183 SACLEEAAR--ERDGLEQALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRS 240
LEE R +++ EQ LRR + E + EE E+L+++ R + ERR
Sbjct: 488 WLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERRE 547
Query: 241 RL-------ELELQSREQDLERAGLRQRERRGRRLQEHAERESQ 277
+L LE + REQ L+R Q ERR + L+ ER Q
Sbjct: 548 QLLKREEEKRLEQERREQRLKR---EQEERRDQLLKREEERRQQ 588
Score = 46.2 bits (108), Expect = 3e-05
Identities = 51/167 (30%), Positives = 75/167 (44%), Gaps = 15/167 (8%)
Query: 111 EETFESGGLDVQGTAGSLDEEEEEEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPE 170
EE + L+ Q EEE++++R + + KQ R +RE+ E
Sbjct: 273 EEEEQLRKLERQELRRERQEEEQQQQRLRREQQ------LRRKQEEERREQQEERREQQE 326
Query: 171 LLGSFEDVLIRASACLEEAARERDGLEQALRRRESEHEREVRALYEETEQLREQSRRPPS 230
E+ R L ER EQ LRR + E RE + E+ E+ REQ R
Sbjct: 327 RREQQEE---RREQQLRREQEERR--EQQLRREQEEERREQQLRREQEEERREQQLRREQ 381
Query: 231 QNFARGERRSRLELELQSREQDLERAGLRQRERRGRRLQEHAERESQ 277
Q R E++ R E +L+ REQ L R +RE++ RR ++ RE Q
Sbjct: 382 Q--LRREQQLRREQQLR-REQQLRREQQLRREQQLRR-EQQLRREQQ 424
Score = 46.2 bits (108), Expect = 3e-05
Identities = 48/160 (30%), Positives = 67/160 (41%), Gaps = 20/160 (12%)
Query: 131 EEEEEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPE------LLGSFEDVLIRASA 184
+ E+EER L++ V + ++R + RL+RE PE LL S E R
Sbjct: 591 KREQEERLEQRLKREEVERLEQEERREQ----RLKREEPEEERRQQLLKSEEQEERRQQQ 646
Query: 185 CLEEAARERDGLEQALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRSR--- 241
E R EQ L+R E E E R E E+ REQ Q AR +SR
Sbjct: 647 LRREQQERR---EQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPK 703
Query: 242 ----LELELQSREQDLERAGLRQRERRGRRLQEHAERESQ 277
LE E +R+ + +Q +R R+ QE R +
Sbjct: 704 WQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRE 743
Score = 43.5 bits (101), Expect = 2e-04
Identities = 47/156 (30%), Positives = 72/156 (46%), Gaps = 15/156 (9%)
Query: 130 EEEEEEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPELLGSFEDVLIRASACLEEA 189
E +EEE++ + + + ++R + R Q+ER E + +R +E
Sbjct: 289 ERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRRE---QEE 345
Query: 190 ARER--------DGLEQALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRSR 241
RE+ + EQ LRR E E ER + L E + REQ R Q R E++ R
Sbjct: 346 RREQQLRREQEEERREQQLRR-EQEEERREQQLRREQQLRREQQLRREQQ--LRREQQLR 402
Query: 242 LELELQSREQDLERAGLRQRERRGRRLQEHAERESQ 277
E +L+ REQ L R +RE++ RR QE E +
Sbjct: 403 REQQLR-REQQLRREQQLRREQQLRREQEEERHEQK 437
Score = 43.1 bits (100), Expect = 3e-04
Identities = 44/149 (29%), Positives = 67/149 (44%), Gaps = 23/149 (15%)
Query: 129 DEEEEEEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPELLGSFEDVLIRASACLEE 188
+EEE ++E + E+ +++ R W R R++ EL E +L EE
Sbjct: 992 EEEELQQEEEQLLREE--------REKRRRQEWERQYRKKDELQQEEEQLL------REE 1037
Query: 189 AARERDGLEQALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRSRLELELQS 248
+ R L+ RE ++ RE L +E EQL + R ++ ER+ R E ELQ
Sbjct: 1038 REKRR------LQERERQY-REEEELQQEEEQLLGEERE--TRRRQELERQYRKEEELQQ 1088
Query: 249 REQDLERAGLRQRERRGRRLQEHAERESQ 277
E+ L R +R R+ R Q E E Q
Sbjct: 1089 EEEQLLREEPEKRRRQERERQCREEEELQ 1117
Score = 42.7 bits (99), Expect = 4e-04
Identities = 39/149 (26%), Positives = 72/149 (48%), Gaps = 15/149 (10%)
Query: 129 DEEEEEEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPELLGSFEDVLIRASACLEE 188
+E ++ E+RF E+ K++ R R +RE+ EL E+ ++ ++
Sbjct: 801 EERQQREQRFLPEEEE--------KEQRRRQ---RREREK-ELQFLEEEEQLQRRERAQQ 848
Query: 189 AARERDGLEQALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRSRLELELQS 248
E DGL++ RR S+ +R + + E+ R++ R A E+ + + LQ
Sbjct: 849 LQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQE 908
Query: 249 REQDLERAGLRQRERRGRRLQEHAERESQ 277
E++L+R +RE+R R+ QE RE +
Sbjct: 909 EEEELQR---EEREKRRRQEQERQYREEE 934
Score = 42.4 bits (98), Expect = 5e-04
Identities = 64/255 (25%), Positives = 102/255 (40%), Gaps = 52/255 (20%)
Query: 41 CDKEAKGFITKHDLQGLQSD-------LPLTPEQLEAVFESLDRAHTGFLTAREFCLGL- 92
CD A +TK DL+ L P P+ ++ + E LD G + EF L +
Sbjct: 23 CDGAA---LTKKDLKNLLEREFGAVLRRPHDPKTVDLILELLDLDSNGRVDFNEFLLFIF 79
Query: 93 ----GMFVGVASAQGANPCRTPEETFESGGLDVQGTAGSLDE--EEEEEERFHTVLEQLG 146
+ + A G + E G L + +EE++ RF QL
Sbjct: 80 KVAQACYYALGQATGLD---------EEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLE 130
Query: 147 VAPVLGKQRAVRTLWARLQRERPELLGSFEDVLIRASACLEEAARERDGLEQALRRRESE 206
P G++R + R ++ER G EE + +++ LEQ R+R E
Sbjct: 131 EEP--GQRRRQK----RQEQERELAEG-------------EEQSEKQERLEQRDRQRRDE 171
Query: 207 HEREVRALYEETEQLREQSRRPPS------QNFARGERRSRLELELQSREQDLERAGLRQ 260
R ++E E+ R + + S + F E+ R EL L+ R + E ++
Sbjct: 172 ELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRREL-LELRRKGREEKQQQR 230
Query: 261 RERRGRRLQEHAERE 275
RER+ R QE E+E
Sbjct: 231 RERQDRVFQEEEEKE 245
Score = 42.0 bits (97), Expect = 6e-04
Identities = 40/149 (26%), Positives = 64/149 (42%), Gaps = 16/149 (10%)
Query: 132 EEEEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPELLGSFEDVLIRASACLEEAAR 191
EE E R LE+ K+ ++ +L RE PE E R C EE
Sbjct: 1066 EERETRRRQELERQ-----YRKEEELQQEEEQLLREEPEKRRRQE----RERQCREEEEL 1116
Query: 192 ERDGLEQALRRRESEHEREVRALYEETEQLREQSRR-----PPSQNFARGERRSRLELEL 246
+++ + RE +E+ Y E E+++++ + P + ER+ R E EL
Sbjct: 1117 QQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEEL 1176
Query: 247 QSREQDLERAGLRQRERRGRRLQEHAERE 275
Q E+ L R Q +RR R +++ E E
Sbjct: 1177 QQEEEQLLRE--EQEKRRQERERQYREEE 1203
Score = 42.0 bits (97), Expect = 6e-04
Identities = 45/174 (25%), Positives = 78/174 (44%), Gaps = 30/174 (17%)
Query: 130 EEEEEEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPELLGSFEDVLIRASAC---- 185
E+ +ER+ +LE+ + P +Q+ R R RE +L E+ +R+
Sbjct: 1738 EQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKF 1797
Query: 186 -LEEAARE-----------RDG----------LEQALRRRESEHEREVRALYEETEQLRE 223
EE R+ RDG LE+ +R E +R+ RA EE +E
Sbjct: 1798 REEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRA--EEQFATQE 1855
Query: 224 QSRRPPSQNFARGERRSRLELELQSREQDLERAGLRQRERRGRRLQEHAERESQ 277
+SRR + + E++ R E E + RE+ + R ++ E+R R++ E +E +
Sbjct: 1856 KSRREEQELWQEEEQKRRQERERKLREEHIRRQ--QKEEQRHRQVGEIKSQEGK 1907
Score = 40.4 bits (93), Expect = 0.002
Identities = 44/166 (26%), Positives = 72/166 (43%), Gaps = 21/166 (12%)
Query: 129 DEEEEEEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPE-LLGSFEDVLIRASACLE 187
++EE E+R E+ + L ++ +R R Q ER E LL E+ + +
Sbjct: 510 EQEERREQRLKRQEEEERLQQRLRSEQQLR----REQEERREQLLKREEEKRLEQERREQ 565
Query: 188 EAARERDGLEQALRRRESEHER-----------EVRALYEETEQLREQSRRPP--SQNFA 234
RE++ L +RE E + E R EE E+L ++ RR +
Sbjct: 566 RLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEP 625
Query: 235 RGERRSRL---ELELQSREQDLERAGLRQRERRGRRLQEHAERESQ 277
ERR +L E + + R+Q L R +RE+R +R +E E +
Sbjct: 626 EEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQR 671
Score = 40.0 bits (92), Expect = 0.002
Identities = 46/160 (28%), Positives = 68/160 (42%), Gaps = 13/160 (8%)
Query: 129 DEEEEEEERFHTVLEQLGVAPVLGKQRAVRT--LWARLQRERPELLGSFEDVLIRASACL 186
++EEE E+ +QL L +++ +R R Q+ R E E L R
Sbjct: 367 EQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR 426
Query: 187 EEAARERDGLEQALRRRES------EHEREVRALYEETEQLREQSRRPPSQNFARGERRS 240
E ER + RRE E R+ EETE+ ++ R+ + ERR
Sbjct: 427 REQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRE 486
Query: 241 R-LELELQSREQDLERAGLR----QRERRGRRLQEHAERE 275
R L+LE + R + ER + Q ERR +RL+ E E
Sbjct: 487 RWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEE 526
Score = 40.0 bits (92), Expect = 0.002
Identities = 43/165 (26%), Positives = 71/165 (43%), Gaps = 23/165 (13%)
Query: 128 LDEEEEEEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPELLGSFEDVLIRASACLE 187
L EEEE+E+R E+ L ++ ++ +RER + L ED L
Sbjct: 811 LPEEEEKEQRRRQRREREKELQFLEEEEQLQ------RRERAQQLQEEEDGLQEDQERRR 864
Query: 188 EAARERDG-----LEQALRRR----------ESEHEREVRALYEETEQLREQSRRPPSQN 232
+ RD LE+ +RR + + +E + L EE E+L+ + R +
Sbjct: 865 SQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREERE--KRR 922
Query: 233 FARGERRSRLELELQSREQDLERAGLRQRERRGRRLQEHAERESQ 277
ER+ R E +LQ E+ L R +R R+ R Q +++ Q
Sbjct: 923 RQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQ 967
Score = 40.0 bits (92), Expect = 0.002
Identities = 47/157 (29%), Positives = 71/157 (45%), Gaps = 29/157 (18%)
Query: 129 DEEEEEEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPELLGSFEDVLIRASACLEE 188
+ + EEE+ EQL L ++R R R +RER R L++
Sbjct: 927 ERQYREEEQLQQEEEQL-----LREEREKRR---RQERERQ----------YRKDKKLQQ 968
Query: 189 AARERDGLEQALRRRESEHE--REVRALYEETEQL-REQSRRPPSQNFARGERRSRLELE 245
+ G E RRR+ + RE L +E EQL RE+ + Q + ER+ R + E
Sbjct: 969 KEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEW---ERQYRKKDE 1025
Query: 246 LQSREQDL-----ERAGLRQRERRGRRLQEHAERESQ 277
LQ E+ L E+ L++RER+ R +E + E Q
Sbjct: 1026 LQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQ 1062
Score = 38.9 bits (89), Expect = 0.005
Identities = 47/167 (28%), Positives = 74/167 (44%), Gaps = 25/167 (14%)
Query: 128 LDEEEEEE----ERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPELLGSFEDVLIRAS 183
L E EE++ ER LE+ +++ +R R RE +LL E+ +R
Sbjct: 1628 LQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRR- 1686
Query: 184 ACLEEAARERDGLEQALRRRESEHE----------REVRALYEETEQLREQSRRPPSQNF 233
+E R+ EQ LRR+E E + +E+ + E EQLR+++ Q
Sbjct: 1687 ---QERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQET----EQEQ 1739
Query: 234 ARGERRSRLELELQSREQDLERAGLRQRERRGRRLQE---HAERESQ 277
R + R R LE + + E LR++ER + +E ERE Q
Sbjct: 1740 LRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQ 1786
Score = 38.5 bits (88), Expect = 0.007
Identities = 33/105 (31%), Positives = 49/105 (46%), Gaps = 14/105 (13%)
Query: 187 EEAARERDGLEQALRRRES-----EHEREVRALYEETE--------QLREQSRRPPSQNF 233
+E R R E+ RRRES E ER R EE + Q E+S R +
Sbjct: 726 QEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLS 785
Query: 234 ARGERRSRLELELQSRE-QDLERAGLRQRERRGRRLQEHAERESQ 277
AR R + E +L++ E Q E+ L + E + +R ++ ERE +
Sbjct: 786 ARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKE 830
Score = 38.1 bits (87), Expect = 0.009
Identities = 41/153 (26%), Positives = 64/153 (41%), Gaps = 14/153 (9%)
Query: 128 LDEEEEEEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPELLGSFEDVLIRASACLE 187
L+ + +EE EQL ++R R R + E L E+ L+R E
Sbjct: 1076 LERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEE----LQQEEEQLLRE----E 1127
Query: 188 EAARERDGLEQALRRRESEHEREVRALYEETEQLREQS--RRPPSQNFARGERRSRLELE 245
R R LE+ R E + E + L EE E+ R Q R+ + + E L E
Sbjct: 1128 REKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREE 1187
Query: 246 LQSREQDLERAGLR----QRERRGRRLQEHAER 274
+ R Q+ ER QR++R +R ++ +R
Sbjct: 1188 QEKRRQERERQYREEEELQRQKRKQRYRDEDQR 1220
Score = 37.0 bits (84), Expect = 0.021
Identities = 45/168 (26%), Positives = 67/168 (39%), Gaps = 28/168 (16%)
Query: 129 DEEEEEEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPELLGSFEDVLIRASACLEE 188
++EE E++ E+ +R + L + ER E E L R E
Sbjct: 342 EQEERREQQLRREQEE---------ERREQQLRREQEEERREQQLRREQQLRREQQLRRE 392
Query: 189 AARERDGL---EQALRRRES-------EHEREVRALYEET--EQLREQSRRPPSQNFARG 236
R+ EQ LRR + E+++R EE EQ EQ RR +
Sbjct: 393 QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQE 452
Query: 237 ERRSRLELELQS-------REQDLERAGLRQRERRGRRLQEHAERESQ 277
ERR L+ E ++ R+Q L+R +R R +L+E RE Q
Sbjct: 453 ERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQ 500
Score = 36.6 bits (83), Expect = 0.027
Identities = 40/155 (25%), Positives = 73/155 (47%), Gaps = 28/155 (18%)
Query: 130 EEEEEEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPELLGSFEDVLIRASACLEEA 189
+E+ ++++ LE+ ++R TL+A+ + ++ L + L+E
Sbjct: 866 QEQRRDQKWRWQLEE-------ERKRRRHTLYAK---------PALQEQLRKEQQLLQEE 909
Query: 190 ARERDGLEQALRRRESEHEREVRALYEETEQLR---EQSRRPPSQNFAR--GERRSRLEL 244
E E+ RRR+ E ER+ Y E EQL+ EQ R + R ER+ R +
Sbjct: 910 EEELQREEREKRRRQ-EQERQ----YREEEQLQQEEEQLLREEREKRRRQERERQYRKDK 964
Query: 245 ELQSREQDL--ERAGLRQRERRGRRLQEHAERESQ 277
+LQ +E+ L E R+R+ R ++ +E E + +
Sbjct: 965 KLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQE 999
Score = 36.6 bits (83), Expect = 0.027
Identities = 40/160 (25%), Positives = 67/160 (41%), Gaps = 22/160 (13%)
Query: 129 DEEEEEEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPELLGSFEDVLIRASACLEE 188
D + EEE+ V Q L +++ +R R RE +LL E+ L
Sbjct: 1429 DRKFREEEQ--QVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQ------LHR 1480
Query: 189 AARERDGLEQALRRRESEHEREV-----------RALYEETEQLREQSRRPPSQNFARGE 237
R+R LE+ + R E +R+ R EE +QL Q R+ + F + E
Sbjct: 1481 QERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQ---RKFLQEE 1537
Query: 238 RRSRLELELQSREQDLERAGLRQRERRGRRLQEHAERESQ 277
++ R + Q R QD +R + + R R ++ R+ +
Sbjct: 1538 QQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQER 1577
Score = 36.2 bits (82), Expect = 0.035
Identities = 25/83 (30%), Positives = 40/83 (48%), Gaps = 6/83 (7%)
Query: 197 EQALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRSRLELELQSREQD-LER 255
EQ +RR+E E R EE +QLR++ R + + R +L Q R++ LE
Sbjct: 1436 EQQVRRQERE-----RKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEE 1490
Query: 256 AGLRQRERRGRRLQEHAERESQP 278
+R+ R R+ +E R +P
Sbjct: 1491 EQQLRRQERDRKFREQELRSQEP 1513
Score = 35.8 bits (81), Expect = 0.046
Identities = 51/166 (30%), Positives = 72/166 (43%), Gaps = 26/166 (15%)
Query: 128 LDEEEEEEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPELLGSFEDVLIRASACLE 187
L EE EE+ R + L ++R + L R +R+R F + +R +
Sbjct: 1321 LREEREEKRRRQETDRKFREEEQLLQEREEQPL-RRQERDR-----KFREEELRH----Q 1370
Query: 188 EAARERDGLEQALRRRESEHE---REVRALYEETEQLREQSR----RPPSQNFARGER-R 239
E R+ EQ LRR+E E + E + +E EQ Q R R Q +R ER R
Sbjct: 1371 EQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDR 1430
Query: 240 SRLELELQSREQDLERAGLRQ----RERRGRRLQEH----AERESQ 277
E E Q R Q+ ER L + R+ R R+ +E ERE Q
Sbjct: 1431 KFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQ 1476
Score = 33.5 bits (75), Expect = 0.23
Identities = 34/136 (25%), Positives = 60/136 (44%), Gaps = 20/136 (14%)
Query: 129 DEEEEEEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPELLGSFEDVLI-----RAS 183
+EEE ++E + E+ +++ R R RE E+ E +L R
Sbjct: 1112 EEEELQQEEEQLLREE--------REKRRRQELERQYREEEEVQQEEEQLLREEPEKRRR 1163
Query: 184 ACLEEAARERDGL----EQALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERR 239
LE RE + L EQ LR + + +E Y E E+L+ Q R+ Q + ++R
Sbjct: 1164 QELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRK---QRYRDEDQR 1220
Query: 240 SRLELELQSREQDLER 255
S L+ + + +++ R
Sbjct: 1221 SDLKWQWEPEKENAVR 1236
Score = 31.2 bits (69), Expect = 1.1
Identities = 28/110 (25%), Positives = 40/110 (36%), Gaps = 23/110 (20%)
Query: 191 RERDGLEQALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRSRLELELQSR- 249
R+R E+ +RR + + + R L E EQ +Q R R E R E Q R
Sbjct: 125 RDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQERE 184
Query: 250 ----------------------EQDLERAGLRQRERRGRRLQEHAERESQ 277
E+ L R L + R+GR ++ RE Q
Sbjct: 185 ERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQ 234
Score = 30.8 bits (68), Expect = 1.5
Identities = 25/77 (32%), Positives = 40/77 (51%), Gaps = 12/77 (15%)
Query: 197 EQALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRSRLELELQSREQDLERA 256
+ LR R+S+ + + L E+ E+ REQ RR R ++R R E E+ LER
Sbjct: 1255 DSQLRDRQSQQDLQ-HLLGEQQERDREQERR-------RWQQRDRHFPE----EEQLERE 1302
Query: 257 GLRQRERRGRRLQEHAE 273
++ +RR R+ QE +
Sbjct: 1303 EQKEAKRRDRKSQEEKQ 1319
Score = 30.4 bits (67), Expect = 1.9
Identities = 30/81 (37%), Positives = 42/81 (51%), Gaps = 17/81 (20%)
Query: 193 RDGLEQALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRSRLELELQSREQD 252
R+ E+ LR E + +RE R L EE E +EQ RR +RR R E ELQ E++
Sbjct: 791 REQRERQLRAEERQ-QREQRFLPEEEE--KEQRRR---------QRRER-EKELQFLEEE 837
Query: 253 LERAGLRQRERRGRRLQEHAE 273
+ QR R ++LQE +
Sbjct: 838 EQ----LQRRERAQQLQEEED 854
Score = 30.0 bits (66), Expect = 2.5
Identities = 25/90 (27%), Positives = 41/90 (45%), Gaps = 8/90 (8%)
Query: 187 EEAARERDGLEQALRRRESEHEREVRALYE-ETEQLREQSRRPPSQNFARGERRSRLELE 245
E+ R ++G +Q + R+ + + + L E E +QL Q R + F E +L
Sbjct: 1601 EQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQER---DRKFLEEEP----QLR 1653
Query: 246 LQSREQDLERAGLRQRERRGRRLQEHAERE 275
Q REQ L R+ + LQE E++
Sbjct: 1654 RQEREQQLRHDRDRKFREEEQLLQEGEEQQ 1683
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 48.5 bits (114), Expect = 7e-06
Identities = 63/253 (24%), Positives = 104/253 (41%), Gaps = 27/253 (10%)
Query: 36 ELFLLCDKEAKGFITKHDLQGLQSDLPLTPEQLEAVFESLDRAHTGFLTAREFCLGLGMF 95
+LF DK G +T + + L QL +++ D G LTA EF L + +
Sbjct: 227 QLFNSHDKTMSGHLTGPQARTILMQSSLPQAQLASIWNLSDIDQDGKLTAEEFILAMHLI 286
Query: 96 VGVASAQGANPCRTPE-------ETFESGGLDVQGTAGSLDEEEEEEERFHTVLEQLGVA 148
S Q P PE G+ V + S+D+ EE +QL
Sbjct: 287 DVAMSGQPLPPVLPPEYIPPSFRRVRSGSGISVISST-SVDQRLPEEPVLEDEQQQL--- 342
Query: 149 PVLGKQRAVRTLWARLQRERPELLGSFEDVLIRASACLEEAARERDGLEQALRRRESEHE 208
++ + + +RE E G+ E + R A LE+ +E++ L Q R + E
Sbjct: 343 -----EKKLPVTFEDKKRENFE-RGNLE-LEKRRQALLEQQRKEQERLAQLERAEQERKE 395
Query: 209 REVR--------ALYEETEQLREQSRRPPSQNFARGERRSRLELELQSREQDLERAGLRQ 260
RE + L ++ E+ RE R+ + ERR + EL+ R++ LE R+
Sbjct: 396 RERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELE-RQRQLEWERNRR 454
Query: 261 RERRGRRLQEHAE 273
+E +R +E +
Sbjct: 455 QELLNQRNKEQED 467
Score = 28.9 bits (63), Expect = 5.7
Identities = 27/89 (30%), Positives = 45/89 (50%), Gaps = 22/89 (24%)
Query: 197 EQALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARG----ERRSRLELELQSREQD 252
E L + + E+++ +E+ ++ +NF RG E+R + LE Q +EQ+
Sbjct: 332 EPVLEDEQQQLEKKLPVTFEDKKR----------ENFERGNLELEKRRQALLEQQRKEQE 381
Query: 253 ----LERAGLRQRERRGRRLQEHAERESQ 277
LERA ++ER+ R QE ER+ Q
Sbjct: 382 RLAQLERA---EQERKERERQEQ-ERKRQ 406
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 48.5 bits (114), Expect = 7e-06
Identities = 63/253 (24%), Positives = 104/253 (41%), Gaps = 27/253 (10%)
Query: 36 ELFLLCDKEAKGFITKHDLQGLQSDLPLTPEQLEAVFESLDRAHTGFLTAREFCLGLGMF 95
+LF DK G +T + + L QL +++ D G LTA EF L + +
Sbjct: 227 QLFNSHDKTMSGHLTGPQARTILMQSSLPQAQLASIWNLSDIDQDGKLTAEEFILAMHLI 286
Query: 96 VGVASAQGANPCRTPE-------ETFESGGLDVQGTAGSLDEEEEEEERFHTVLEQLGVA 148
S Q P PE G+ V + S+D+ EE +QL
Sbjct: 287 DVAMSGQPLPPVLPPEYIPPSFRRVRSGSGISVISST-SVDQRLPEEPVLEDEQQQL--- 342
Query: 149 PVLGKQRAVRTLWARLQRERPELLGSFEDVLIRASACLEEAARERDGLEQALRRRESEHE 208
++ + + +RE E G+ E + R A LE+ +E++ L Q R + E
Sbjct: 343 -----EKKLPVTFEDKKRENFE-RGNLE-LEKRRQALLEQQRKEQERLAQLERAEQERKE 395
Query: 209 REVR--------ALYEETEQLREQSRRPPSQNFARGERRSRLELELQSREQDLERAGLRQ 260
RE + L ++ E+ RE R+ + ERR + EL+ R++ LE R+
Sbjct: 396 RERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELE-RQRQLEWERNRR 454
Query: 261 RERRGRRLQEHAE 273
+E +R +E +
Sbjct: 455 QELLNQRNKEQED 467
Score = 28.9 bits (63), Expect = 5.7
Identities = 27/89 (30%), Positives = 45/89 (50%), Gaps = 22/89 (24%)
Query: 197 EQALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARG----ERRSRLELELQSREQD 252
E L + + E+++ +E+ ++ +NF RG E+R + LE Q +EQ+
Sbjct: 332 EPVLEDEQQQLEKKLPVTFEDKKR----------ENFERGNLELEKRRQALLEQQRKEQE 381
Query: 253 ----LERAGLRQRERRGRRLQEHAERESQ 277
LERA ++ER+ R QE ER+ Q
Sbjct: 382 RLAQLERA---EQERKERERQEQ-ERKRQ 406
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 48.5 bits (114), Expect = 7e-06
Identities = 42/150 (28%), Positives = 72/150 (48%), Gaps = 10/150 (6%)
Query: 131 EEEEEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPELLGSFEDVLIRASACLEEAA 190
EEEEEE E + V G+ +R + RLQ+E E + L R E+
Sbjct: 327 EEEEEEVPEQEGEPSSIVNVPGES-TLRRDFLRLQQENKER----SEALRRQQLLQEQQL 381
Query: 191 RERDGLEQAL---RRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRSRLELEL- 246
RE++ ++ L R++ E ++E R EE ++ ++RR + R E+ + LE
Sbjct: 382 REQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEEL 441
Query: 247 -QSREQDLERAGLRQRERRGRRLQEHAERE 275
+ R+++ ER + +RR R QE+ R+
Sbjct: 442 ERRRKEEEERRRAEEEKRRVEREQEYIRRQ 471
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 48.5 bits (114), Expect = 7e-06
Identities = 42/150 (28%), Positives = 72/150 (48%), Gaps = 10/150 (6%)
Query: 131 EEEEEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPELLGSFEDVLIRASACLEEAA 190
EEEEEE E + V G+ +R + RLQ+E E + L R E+
Sbjct: 327 EEEEEEVPEQEGEPSSIVNVPGES-TLRRDFLRLQQENKER----SEALRRQQLLQEQQL 381
Query: 191 RERDGLEQAL---RRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRSRLELEL- 246
RE++ ++ L R++ E ++E R EE ++ ++RR + R E+ + LE
Sbjct: 382 REQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEEL 441
Query: 247 -QSREQDLERAGLRQRERRGRRLQEHAERE 275
+ R+++ ER + +RR R QE+ R+
Sbjct: 442 ERRRKEEEERRRAEEEKRRVEREQEYIRRQ 471
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 48.5 bits (114), Expect = 7e-06
Identities = 42/150 (28%), Positives = 72/150 (48%), Gaps = 10/150 (6%)
Query: 131 EEEEEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPELLGSFEDVLIRASACLEEAA 190
EEEEEE E + V G+ +R + RLQ+E E + L R E+
Sbjct: 327 EEEEEEVPEQEGEPSSIVNVPGES-TLRRDFLRLQQENKER----SEALRRQQLLQEQQL 381
Query: 191 RERDGLEQAL---RRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRSRLELEL- 246
RE++ ++ L R++ E ++E R EE ++ ++RR + R E+ + LE
Sbjct: 382 REQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEEL 441
Query: 247 -QSREQDLERAGLRQRERRGRRLQEHAERE 275
+ R+++ ER + +RR R QE+ R+
Sbjct: 442 ERRRKEEEERRRAEEEKRRVEREQEYIRRQ 471
>gi|56549694 enabled homolog isoform a [Homo sapiens]
Length = 591
Score = 46.6 bits (109), Expect = 3e-05
Identities = 44/113 (38%), Positives = 55/113 (48%), Gaps = 18/113 (15%)
Query: 163 RLQRERPELLGSFEDVLIRASACLEEAARERDGLEQALRRRESEHEREVRALYEETEQLR 222
RL+RER E + L R LE ER+ LEQ RE + ERE + E E+L
Sbjct: 160 RLERERME-----RERLERER--LERERLERERLEQEQLERERQ-ERERQERLERQERLE 211
Query: 223 EQSRRPPSQNFARGERRSRLELELQSREQDLERAGLRQRERRGRRLQEHAERE 275
Q R ER+ RL+ E Q R Q+ ER +RER+ R QE ERE
Sbjct: 212 RQERL---------ERQERLDRERQER-QERERLERLERERQERERQEQLERE 254
Score = 44.3 bits (103), Expect = 1e-04
Identities = 32/93 (34%), Positives = 43/93 (46%), Gaps = 1/93 (1%)
Query: 186 LEEAARERDGLE-QALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRSRLEL 244
LE ER+ +E + L R E ER R E+ + RE+ R + R ER R E
Sbjct: 156 LERERLERERMERERLERERLERERLERERLEQEQLERERQERERQERLERQERLERQER 215
Query: 245 ELQSREQDLERAGLRQRERRGRRLQEHAERESQ 277
+ D ER ++RER R +E ERE Q
Sbjct: 216 LERQERLDRERQERQERERLERLERERQERERQ 248
Score = 41.6 bits (96), Expect = 8e-04
Identities = 33/97 (34%), Positives = 45/97 (46%), Gaps = 5/97 (5%)
Query: 186 LEEAARERDGLEQALRRRESEHEREVRALYE----ETEQLREQSRRPPSQNFARGERRSR 241
L+E R+++ + L R E ER R E E E+L ++ Q R ER R
Sbjct: 147 LQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQLERERQERERQERLER 206
Query: 242 LE-LELQSREQDLERAGLRQRERRGRRLQEHAERESQ 277
E LE Q R + ER ++ER+ R E ERE Q
Sbjct: 207 QERLERQERLERQERLDRERQERQERERLERLERERQ 243
>gi|39930375 enabled homolog isoform b [Homo sapiens]
Length = 570
Score = 46.6 bits (109), Expect = 3e-05
Identities = 44/113 (38%), Positives = 55/113 (48%), Gaps = 18/113 (15%)
Query: 163 RLQRERPELLGSFEDVLIRASACLEEAARERDGLEQALRRRESEHEREVRALYEETEQLR 222
RL+RER E + L R LE ER+ LEQ RE + ERE + E E+L
Sbjct: 160 RLERERME-----RERLERER--LERERLERERLEQEQLERERQ-ERERQERLERQERLE 211
Query: 223 EQSRRPPSQNFARGERRSRLELELQSREQDLERAGLRQRERRGRRLQEHAERE 275
Q R ER+ RL+ E Q R Q+ ER +RER+ R QE ERE
Sbjct: 212 RQERL---------ERQERLDRERQER-QERERLERLERERQERERQEQLERE 254
Score = 44.3 bits (103), Expect = 1e-04
Identities = 32/93 (34%), Positives = 43/93 (46%), Gaps = 1/93 (1%)
Query: 186 LEEAARERDGLE-QALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRSRLEL 244
LE ER+ +E + L R E ER R E+ + RE+ R + R ER R E
Sbjct: 156 LERERLERERMERERLERERLERERLERERLEQEQLERERQERERQERLERQERLERQER 215
Query: 245 ELQSREQDLERAGLRQRERRGRRLQEHAERESQ 277
+ D ER ++RER R +E ERE Q
Sbjct: 216 LERQERLDRERQERQERERLERLERERQERERQ 248
Score = 41.6 bits (96), Expect = 8e-04
Identities = 33/97 (34%), Positives = 45/97 (46%), Gaps = 5/97 (5%)
Query: 186 LEEAARERDGLEQALRRRESEHEREVRALYE----ETEQLREQSRRPPSQNFARGERRSR 241
L+E R+++ + L R E ER R E E E+L ++ Q R ER R
Sbjct: 147 LQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQLERERQERERQERLER 206
Query: 242 LE-LELQSREQDLERAGLRQRERRGRRLQEHAERESQ 277
E LE Q R + ER ++ER+ R E ERE Q
Sbjct: 207 QERLERQERLERQERLDRERQERQERERLERLERERQ 243
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 45.8 bits (107), Expect = 4e-05
Identities = 44/158 (27%), Positives = 68/158 (43%), Gaps = 23/158 (14%)
Query: 131 EEEEEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPELLGSFEDVLIRASACLEEAA 190
++EEEER H L Q + + E E L + R + E+
Sbjct: 652 QQEEEERRHQELLQ------------------KKKEEEQERLRKAAEAK-RLAEQREQER 692
Query: 191 RERDGLEQALR---RRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRSRLELELQ 247
RE++ EQ R RRE E + R L E+ E+ REQ R + E+ RL+ E
Sbjct: 693 REQERREQERREQERREQERREQERQLAEQ-ERRREQERLQAERELQEREKALRLQKEQL 751
Query: 248 SREQDLERAGLRQRERRGRRLQEHAERESQPATATGAA 285
RE + ++ Q+ R+LQE E++++ A A
Sbjct: 752 QRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKA 789
Score = 40.0 bits (92), Expect = 0.002
Identities = 32/108 (29%), Positives = 54/108 (50%), Gaps = 6/108 (5%)
Query: 176 EDVLIRASACLEEAARERDGLEQALRRRESEHEREVRALYEETEQLREQS--RRPPSQNF 233
E+ L A + AA++ + +E RR++ E R +R L +E E+ R Q ++ +
Sbjct: 615 EERLAEEKAKKKAAAKKMEEVEA--RRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQ 672
Query: 234 ARGERRSRLELELQSREQDLERAGLRQRERR--GRRLQEHAERESQPA 279
R + + + + REQ+ R++ERR RR QE E+E Q A
Sbjct: 673 ERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLA 720
Score = 33.9 bits (76), Expect = 0.18
Identities = 26/117 (22%), Positives = 56/117 (47%), Gaps = 4/117 (3%)
Query: 163 RLQRERPELLGSFEDVLIRASACLEEAARERDGLEQALRRRESEHEREVRALYEETEQLR 222
R Q+ + E+V ++ L + + R+ +EQ ++ + E++ + E+TE+ +
Sbjct: 555 RRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAK 614
Query: 223 EQSRRPPSQNFARGERRSRLELELQSREQDLERAGLR--QRERRGRRLQEHAERESQ 277
E+ R + + ++E R+Q+ E LR Q+E RR QE +++ +
Sbjct: 615 EE--RLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKE 669
Score = 31.2 bits (69), Expect = 1.1
Identities = 22/96 (22%), Positives = 43/96 (44%), Gaps = 8/96 (8%)
Query: 191 RERDGLEQALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRSRLELELQSRE 250
+ER LE R+ E+E R +++ E RR + + E R R L+ + R
Sbjct: 537 KERQRLENLRRKEEAEQLRR--------QKVEEDKRRRLEEVKLKREERLRKVLQARERV 588
Query: 251 QDLERAGLRQRERRGRRLQEHAERESQPATATGAAQ 286
+ ++ +Q E++ ++ E E+ + A A+
Sbjct: 589 EQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAK 624
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 45.8 bits (107), Expect = 4e-05
Identities = 44/158 (27%), Positives = 68/158 (43%), Gaps = 23/158 (14%)
Query: 131 EEEEEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPELLGSFEDVLIRASACLEEAA 190
++EEEER H L Q + + E E L + R + E+
Sbjct: 648 QQEEEERRHQELLQ------------------KKKEEEQERLRKAAEAK-RLAEQREQER 688
Query: 191 RERDGLEQALR---RRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRSRLELELQ 247
RE++ EQ R RRE E + R L E+ E+ REQ R + E+ RL+ E
Sbjct: 689 REQERREQERREQERREQERREQERQLAEQ-ERRREQERLQAERELQEREKALRLQKEQL 747
Query: 248 SREQDLERAGLRQRERRGRRLQEHAERESQPATATGAA 285
RE + ++ Q+ R+LQE E++++ A A
Sbjct: 748 QRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKA 785
Score = 40.0 bits (92), Expect = 0.002
Identities = 32/108 (29%), Positives = 54/108 (50%), Gaps = 6/108 (5%)
Query: 176 EDVLIRASACLEEAARERDGLEQALRRRESEHEREVRALYEETEQLREQS--RRPPSQNF 233
E+ L A + AA++ + +E RR++ E R +R L +E E+ R Q ++ +
Sbjct: 611 EERLAEEKAKKKAAAKKMEEVEA--RRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQ 668
Query: 234 ARGERRSRLELELQSREQDLERAGLRQRERR--GRRLQEHAERESQPA 279
R + + + + REQ+ R++ERR RR QE E+E Q A
Sbjct: 669 ERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLA 716
Score = 35.0 bits (79), Expect = 0.079
Identities = 53/278 (19%), Positives = 113/278 (40%), Gaps = 34/278 (12%)
Query: 2 ASPGKPGADEAQEEEGELEGGSAGPRAAILEQAEELFLLCDKEAKGFITKHDLQGLQSDL 61
+SP P A + + + + +G P++A +++ + + + + + + +LQ +S
Sbjct: 420 SSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQ-AVSELDEEQHLEDEELQPPRSKT 478
Query: 62 PLTPEQLEAVFESLDRAHTGFLTAREFCLGLGMFVGVASAQGANPCRTPEETFESGGLDV 121
P +P V L R + + + P P +S
Sbjct: 479 PSSPCPASKVVRPL-RTFLHTVQRNQMLM--------------TPTSAPRSVMKS--FIK 521
Query: 122 QGTAGSLDEEEEEEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPELLGSFEDVLIR 181
+ T +D +E+E +R LE L +R R Q+ + E+V ++
Sbjct: 522 RNTPLRMDPKEKERQR----LENL--------RRKEEAEQLRRQKVEEDKRRRLEEVKLK 569
Query: 182 ASACLEEAARERDGLEQALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRSR 241
L + + R+ +EQ ++ + E++ + E+TE+ +E+ R + + +
Sbjct: 570 REERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEE--RLAEEKAKKKAAAKK 627
Query: 242 LELELQSREQDLERAGLR--QRERRGRRLQEHAERESQ 277
+E R+Q+ E LR Q+E RR QE +++ +
Sbjct: 628 MEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKE 665
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 45.1 bits (105), Expect = 8e-05
Identities = 35/153 (22%), Positives = 73/153 (47%), Gaps = 5/153 (3%)
Query: 129 DEEEEEEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPELLGSFEDVLIRASACLEE 188
++ +EEE+ Q A + ++ +R ++ RE+ E++ E+ + + E
Sbjct: 364 EKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKI-REQEEMMQEQEEKMGEQEEKMWE 422
Query: 189 AARERDGLEQALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRSRL---ELE 245
E E+ +RR+E + + + + E+ E++REQ Q GE+ ++ E +
Sbjct: 423 QEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAK 482
Query: 246 LQSREQDLERAGLRQRERRGR-RLQEHAERESQ 277
+Q +E+ + R + RE+ + R QE RE +
Sbjct: 483 MQEQEEKMRRQEEKIREQEKKIREQEEKIREQE 515
Score = 41.2 bits (95), Expect = 0.001
Identities = 32/152 (21%), Positives = 73/152 (48%), Gaps = 15/152 (9%)
Query: 129 DEEEEEEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPELLGSFEDVLIRASACLEE 188
+E +E+EE+ E+ + +++ +R ++ RE+ E++ E+ + + E
Sbjct: 425 EEMQEQEEKMRRQEEK-----IREQEKKIREQEEKI-REQEEMMQEQEEKMGEQEGKMCE 478
Query: 189 AARERDGLEQALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRSRL---ELE 245
+ E+ +RR+E + + + + E+ E++REQ Q E+ ++ E +
Sbjct: 479 QEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEK 538
Query: 246 LQSREQDLERAGLRQRERRGR------RLQEH 271
+Q +E+ + R + RE+ R ++QEH
Sbjct: 539 MQEQEEKMRRQEEKMREQEVRLRQQEEKMQEH 570
Score = 39.7 bits (91), Expect = 0.003
Identities = 41/173 (23%), Positives = 76/173 (43%), Gaps = 13/173 (7%)
Query: 111 EETFESGGLDVQGTAGSLDEEEEEEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPE 170
EE + +Q + E+EE+ R E++ +R +W + ++ R
Sbjct: 294 EEKIQEREEKIQEQEEKIREQEEKMRR----QEEMMWEKEEKMRRQEEMMWEKEEKIREL 349
Query: 171 LLGSFEDVLIRASACLEEAARERDGLEQALRRRESEHE--REVRALYEETEQLREQSRRP 228
E IR EE +E + + + +R+E E + R+ + E+ E++REQ
Sbjct: 350 EEKMHEQEKIREQ---EEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMM 406
Query: 229 PSQNFARGERRSRL---ELELQSREQDLERAGLRQRERRGR-RLQEHAERESQ 277
Q GE+ ++ E E+Q +E+ + R + RE+ + R QE RE +
Sbjct: 407 QEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQE 459
Score = 36.2 bits (82), Expect = 0.035
Identities = 34/148 (22%), Positives = 68/148 (45%), Gaps = 14/148 (9%)
Query: 130 EEEEEEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPELLGSFEDVLIRASACLEEA 189
+EE+ +ER + EQ + +R +++R+ E++ E+ + R + E
Sbjct: 293 QEEKIQEREEKIQEQ---------EEKIREQEEKMRRQE-EMMWEKEEKMRRQEEMMWEK 342
Query: 190 ARERDGLEQALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRSRLELELQSR 249
+ LE+ + +E E+E + +E E++REQ +R + + E E + R
Sbjct: 343 EEKIRELEEKMHEQEKIREQEEKR--QEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIR 400
Query: 250 EQDLERAGLRQRERRGRRLQEHAERESQ 277
EQ E Q E+ G + ++ E+E +
Sbjct: 401 EQ--EEMMQEQEEKMGEQEEKMWEQEEE 426
Score = 33.9 bits (76), Expect = 0.18
Identities = 29/109 (26%), Positives = 52/109 (47%), Gaps = 11/109 (10%)
Query: 181 RASACLEEAARERDGLEQALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRS 240
+A +EE +ERD L L R E L E+ +L+E+ + S+ +S
Sbjct: 178 KADRYIEELTKERDALSLELYRNTITDEE----LKEKNAKLQEKLQLVESE-------KS 226
Query: 241 RLELELQSREQDLERAGLRQRERRGRRLQEHAERESQPATATGAAQGAE 289
++L ++ ++ LERA L +++ + +H +E Q +A AQ E
Sbjct: 227 EIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEE 275
Score = 33.9 bits (76), Expect = 0.18
Identities = 28/121 (23%), Positives = 52/121 (42%), Gaps = 6/121 (4%)
Query: 163 RLQRERPELLGSFEDVLIRASACLEEAA---RERDGLEQALRRRESEHEREVRALYEETE 219
+LQ E L + V + A +EE R E+ + R+E + + + E+ E
Sbjct: 250 QLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEE 309
Query: 220 QLREQS---RRPPSQNFARGERRSRLELELQSREQDLERAGLRQRERRGRRLQEHAERES 276
++REQ RR + + E+ R E + +E+ + + E+ R QE +E
Sbjct: 310 KIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEE 369
Query: 277 Q 277
+
Sbjct: 370 E 370
>gi|81295809 pericentrin [Homo sapiens]
Length = 3336
Score = 45.1 bits (105), Expect = 8e-05
Identities = 37/140 (26%), Positives = 61/140 (43%), Gaps = 8/140 (5%)
Query: 158 RTLWARLQRERPELLGSFEDVLIRASACLEEAARERDGLEQALRRRESEHEREVRALYEE 217
+ L A+ Q E +L F+ L A LE+ ++++ E+ALR ES H+ + L E+
Sbjct: 363 KELSAKHQSEMEDLQNQFQKELAEQRAELEKIFQDKNQAERALRNLESHHQAAIEKLRED 422
Query: 218 TEQLREQSRRPPSQNFARGERRSRLELE-LQSREQDLERAGLRQRERRGRRL-------Q 269
+ + F E+ +LELE LQ+ +DL+ + R +L Q
Sbjct: 423 LQSEHGRCLEDLEFKFKESEKEKQLELENLQASYEDLKAQSQEEIRRLWSQLDSARTSRQ 482
Query: 270 EHAERESQPATATGAAQGAE 289
E +E Q T + E
Sbjct: 483 ELSELHEQLLARTSRVEDLE 502
Score = 38.5 bits (88), Expect = 0.007
Identities = 35/136 (25%), Positives = 61/136 (44%), Gaps = 19/136 (13%)
Query: 154 QRAVRTLWARL---QRERPELLGSFEDVLIRASACLEEAARERDGLEQALRRRESEHERE 210
Q +R LW++L + R EL E +L R S + LEQ +R +++HE E
Sbjct: 464 QEEIRRLWSQLDSARTSRQELSELHEQLLARTSRV--------EDLEQLKQREKTQHESE 515
Query: 211 VRALYEETEQLREQSRRPPSQNFARGERR---SRLELELQSREQDLERAGLRQRERRGRR 267
+ L E+ + + ++ ++R +R + L S E L GL ++ +GR+
Sbjct: 516 LEQLRIYFEKKLRDAEKTYQEDLTLLQQRLQGAREDALLDSVEVGLSCVGLEEKPEKGRK 575
Query: 268 -----LQEHAERESQP 278
L+ +ES P
Sbjct: 576 DHVDELEPERHKESLP 591
Score = 32.3 bits (72), Expect = 0.51
Identities = 35/127 (27%), Positives = 55/127 (43%), Gaps = 13/127 (10%)
Query: 178 VLIRASACLEEAARERDGLEQALRRRESEHEREVRALYEETEQLR-EQSRRPPSQNFARG 236
V+ S+ +EE + L++ +R + E E+ L+E E+L+ E S P +
Sbjct: 1706 VIYTRSSEIEELKATIENLQENQKRLQKEKAEEIEQLHEVIEKLQHELSLMGPVVHEVSD 1765
Query: 237 ERRSRLELEL----------QSREQDLERAGLRQRERRGRRLQEHAERESQPATA-TGAA 285
+ L+ EL Q+ + +LE A L +E R L + R SQ A
Sbjct: 1766 SQAGSLQSELLCSQAGGPRGQALQGELE-AALEAKEALSRLLADQERRHSQALEALQQRL 1824
Query: 286 QGAEYTA 292
QGAE A
Sbjct: 1825 QGAEEAA 1831
Score = 28.1 bits (61), Expect = 9.6
Identities = 27/130 (20%), Positives = 54/130 (41%), Gaps = 14/130 (10%)
Query: 148 APVLGKQRAVRTLWARLQRERPELLGSFEDVLIRASACLEEAARERDGLEQALRRRESEH 207
A VLG + + + LQ E E + + L+ R +D LE+ +H
Sbjct: 668 ARVLGLETEHKVQLSLLQTELKEEIELLKIENRNLYGKLQHETRLKDDLEKVKHNLIEDH 727
Query: 208 EREVRALYEETEQLREQSRRPPSQNFARGERRSRLELELQSREQDLERAGLRQRERRGRR 267
++E+ ++TE ++++ +R E + + +++L+R +
Sbjct: 728 QKELNNAKQKTELMKQEFQRK--------------ETDWKVMKEELQREAEEKLTLMLLE 773
Query: 268 LQEHAERESQ 277
L+E AE E Q
Sbjct: 774 LREKAESEKQ 783
>gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]
Length = 1564
Score = 44.3 bits (103), Expect = 1e-04
Identities = 35/93 (37%), Positives = 46/93 (49%), Gaps = 8/93 (8%)
Query: 187 EEAARERDGLEQALRRRESEHERE-VRALYEETEQLREQSR-RPPSQNFARGERRSRLEL 244
+E ARERD + R RE E ERE R +E E RE++R R + R R R
Sbjct: 673 DERARERDRERERDRERERERERERDREREKERELERERAREREREREKERDRERDR--- 729
Query: 245 ELQSREQDLERAGLRQRERRGRRLQEHAERESQ 277
R+ D ER R+R+R R +E ERE +
Sbjct: 730 ---DRDHDRERERERERDREKEREREREERERE 759
Score = 42.0 bits (97), Expect = 6e-04
Identities = 35/116 (30%), Positives = 51/116 (43%), Gaps = 6/116 (5%)
Query: 163 RLQRERPELLGSFEDVLIRASACLEEAARERDGLEQALRRRESEHEREVRALYEETEQLR 222
R + R + + D R E RER+ + R RE E ERE+ E E+ R
Sbjct: 659 RREERRVDRVDDRRDERARERDRERERDRERERERERERDREREKEREL-----ERERAR 713
Query: 223 EQSR-RPPSQNFARGERRSRLELELQSREQDLERAGLRQRERRGRRLQEHAERESQ 277
E+ R R ++ R R + RE+D E+ R+RE R R + ERE +
Sbjct: 714 EREREREKERDRERDRDRDHDRERERERERDREKEREREREERERERERERERERE 769
Score = 38.9 bits (89), Expect = 0.005
Identities = 36/101 (35%), Positives = 48/101 (47%), Gaps = 12/101 (11%)
Query: 188 EAARERDGLEQALRRRESEHEREVRALYEETEQLREQSR-RPPSQNFARGERRSR----- 241
E RER+ R +E E ERE RA E E+ +E+ R R ++ R R R
Sbjct: 688 ERERERERERDREREKERELERE-RAREREREREKERDRERDRDRDHDRERERERERDRE 746
Query: 242 --LELELQSREQDLERAGLRQRER---RGRRLQEHAERESQ 277
E E + RE++ ER R+RER R R + ERE Q
Sbjct: 747 KEREREREERERERERERERERERERERERARERDKERERQ 787
Score = 37.0 bits (84), Expect = 0.021
Identities = 27/91 (29%), Positives = 40/91 (43%), Gaps = 5/91 (5%)
Query: 187 EEAARERDGLEQALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRSRLELEL 246
+E RERD R RE E ER+ E E+ RE+ R + R R R
Sbjct: 721 KERDRERDRDRDHDRERERERERD-----REKEREREREERERERERERERERERERERE 775
Query: 247 QSREQDLERAGLRQRERRGRRLQEHAERESQ 277
++RE+D ER R E + + + E+ +
Sbjct: 776 RARERDKERERQRDWEDKDKGRDDRREKREE 806
Score = 36.2 bits (82), Expect = 0.035
Identities = 30/88 (34%), Positives = 45/88 (51%), Gaps = 3/88 (3%)
Query: 188 EAARERDGLEQALRRRESEHEREV-RALYEETEQLREQSRRPPSQNFARGERRSRLELEL 246
E ARER+ + R RE + +R+ R E E+ RE+ R + R R R E E
Sbjct: 710 ERAREREREREKERDRERDRDRDHDRERERERERDREKEREREREERERERERER-ERE- 767
Query: 247 QSREQDLERAGLRQRERRGRRLQEHAER 274
+ RE++ ERA R +ER +R E ++
Sbjct: 768 RERERERERARERDKERERQRDWEDKDK 795
Score = 35.4 bits (80), Expect = 0.060
Identities = 28/88 (31%), Positives = 41/88 (46%), Gaps = 2/88 (2%)
Query: 192 ERDGLEQALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRSRLELELQ-SRE 250
ERD + R + R+ RA + E+ R++ R + ER ELE + +RE
Sbjct: 655 ERDERREERRVDRVDDRRDERARERDRERERDRERERERERERDREREKERELERERARE 714
Query: 251 QDLERAGLRQRER-RGRRLQEHAERESQ 277
++ ER R RER R R ERE +
Sbjct: 715 REREREKERDRERDRDRDHDRERERERE 742
Score = 33.9 bits (76), Expect = 0.18
Identities = 25/84 (29%), Positives = 40/84 (47%), Gaps = 7/84 (8%)
Query: 191 RERDGLEQALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRSRLELELQSRE 250
RER+ + R +E E ERE R E E+ RE+ R R R+R + + R+
Sbjct: 735 RERERERERDREKEREREREERERERERERERERERE-------RERERARERDKERERQ 787
Query: 251 QDLERAGLRQRERRGRRLQEHAER 274
+D E + +RR +R + +R
Sbjct: 788 RDWEDKDKGRDDRREKREEIREDR 811
Score = 32.7 bits (73), Expect = 0.39
Identities = 22/81 (27%), Positives = 36/81 (44%), Gaps = 1/81 (1%)
Query: 195 GLEQALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRSRLELELQSREQDLE 254
G L R E ER V + + ++ + R ++ R R R + +E++LE
Sbjct: 649 GRNDELERDERREERRVDRVDDRRDERARERDRERERDRERERERERERDREREKERELE 708
Query: 255 RAGLRQRERRGRRLQEHAERE 275
R R+RER R + ER+
Sbjct: 709 RERARERERE-REKERDRERD 728
Score = 31.6 bits (70), Expect = 0.87
Identities = 26/84 (30%), Positives = 39/84 (46%), Gaps = 4/84 (4%)
Query: 187 EEAARERDGLEQALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRSRLELEL 246
E ER+ + R RE E ERE R E ++ RE+ R ++ R +RR + E
Sbjct: 750 EREREERERERERERERERERERE-RERARERDKERERQRDWEDKDKGRDDRREKRE--- 805
Query: 247 QSREQDLERAGLRQRERRGRRLQE 270
+ RE R G +R+ + R E
Sbjct: 806 EIREDRNPRDGHDERKSKKRYRNE 829
Score = 30.8 bits (68), Expect = 1.5
Identities = 30/95 (31%), Positives = 40/95 (42%), Gaps = 12/95 (12%)
Query: 188 EAARERDGLEQALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRSRLELELQ 247
E RER+ R RE E ERE E E+ RE+ R + ER E +
Sbjct: 736 ERERERE------RDREKEREREREERERERERERERERERERERERARERDKERERQRD 789
Query: 248 SREQDLERAGLRQ-----RERRGRRLQEHAERESQ 277
++D R R+ RE R R H ER+S+
Sbjct: 790 WEDKDKGRDDRREKREEIREDRNPR-DGHDERKSK 823
Score = 30.4 bits (67), Expect = 1.9
Identities = 29/89 (32%), Positives = 43/89 (48%), Gaps = 9/89 (10%)
Query: 192 ERDGLEQALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRSRLELELQSREQ 251
ERD +QA R+S ER R + RE+ +RP S +G R LE + + E+
Sbjct: 610 ERDNRDQA---RDSSFER--RHGERDRRDNRERDQRPSSPIRHQG-RNDELERDERREER 663
Query: 252 DLERAGLRQRER---RGRRLQEHAERESQ 277
++R R+ ER R R + ERE +
Sbjct: 664 RVDRVDDRRDERARERDRERERDRERERE 692
Score = 30.0 bits (66), Expect = 2.5
Identities = 21/70 (30%), Positives = 32/70 (45%), Gaps = 2/70 (2%)
Query: 194 DGLEQALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRSRLELELQSREQDL 253
D ++ R EH+RE +T Q + R +++ R R RL + RE+D
Sbjct: 1294 DSRDRLQERDRYEHDRERERERRDTRQ--REWDRDADKDWPRNRDRDRLRERERERERDK 1351
Query: 254 ERAGLRQRER 263
R R+RER
Sbjct: 1352 RRDLDRERER 1361
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 43.9 bits (102), Expect = 2e-04
Identities = 30/150 (20%), Positives = 74/150 (49%), Gaps = 4/150 (2%)
Query: 129 DEEEEEEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPELLGSFEDVLIRASACLEE 188
++ +++EE+ EQ+ +++ + L + Q E+ E G E+ + + E
Sbjct: 248 EQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMRE 307
Query: 189 AARERDGLEQALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRSRLE-LELQ 247
+ E+ +R +E + ++ ++E+ EQ+ EQ + Q GE+ +++ E Q
Sbjct: 308 QEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQ 367
Query: 248 SREQDLERAGLRQRERRGRRLQEHAERESQ 277
R+Q+ + +R++E + R+ +E ++ +
Sbjct: 368 VRKQEEQ---MRKQEEQMRKQEEQMRKQEE 394
Score = 38.5 bits (88), Expect = 0.007
Identities = 30/149 (20%), Positives = 68/149 (45%), Gaps = 6/149 (4%)
Query: 129 DEEEEEEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPELLGSFEDVLIRASACLEE 188
++E + E+ + EQ G +G+Q +++ E +G E+ + + + E
Sbjct: 182 EQEGQVREQEGQMGEQEGQ---MGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGE 238
Query: 189 AARERDGLEQALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRSRLELELQS 248
+ E+ ++++E + ++ + E+ EQ+REQ + Q + E E Q
Sbjct: 239 QEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQM 298
Query: 249 REQDLERAGLRQRERRGRRLQEHAERESQ 277
REQ+ + +R++E + R +E + +
Sbjct: 299 REQEEQ---MREQEEQMREQEEQMREQEE 324
Score = 35.4 bits (80), Expect = 0.060
Identities = 29/149 (19%), Positives = 69/149 (46%), Gaps = 22/149 (14%)
Query: 129 DEEEEEEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPELLGSFEDVLIRASACLEE 188
++ E+EE+ EQ+G + +W E+ E + ++ + + + E
Sbjct: 310 EQMREQEEQMREQEEQMG--------KQEEQMW-----EQKEQMWEQKEQMWKQEEQMGE 356
Query: 189 AARERDGLEQALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRSRLELELQS 248
+ E+ +R++E + ++ + ++ EQ+R+Q + Q GE++ Q
Sbjct: 357 QEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKE------QM 410
Query: 249 REQDLERAGLRQRERRGRRLQEHAERESQ 277
REQ+ E+ G +++ + R+ +EH + +
Sbjct: 411 REQE-EQMG--EQKEQMRKQEEHMGEQKE 436
Score = 32.0 bits (71), Expect = 0.67
Identities = 27/92 (29%), Positives = 45/92 (48%), Gaps = 6/92 (6%)
Query: 187 EEAARERDGLEQALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRSRL-ELE 245
E RE++G + + E E +VR E+ Q+REQ + Q GE+ ++ E E
Sbjct: 149 EGQVREQEGQVREQEGQVREQEGQVR---EQEGQVREQEGQVREQEGQMGEQEGQMGEQE 205
Query: 246 LQSREQDLERAGLRQRERRGRRLQEHAERESQ 277
Q EQ E +Q E+ G + ++ ++E Q
Sbjct: 206 EQMGEQ--EEQMQKQEEQMGEQEEQMRKQEEQ 235
Score = 32.0 bits (71), Expect = 0.67
Identities = 23/91 (25%), Positives = 45/91 (49%), Gaps = 4/91 (4%)
Query: 187 EEAARERDGLEQALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRSRLELEL 246
E RE++G + + E E +VR E+ Q+REQ + Q GE+ ++ +
Sbjct: 156 EGQVREQEGQVREQEGQVREQEGQVR---EQEGQVREQEGQMGEQEGQMGEQEEQMGEQE 212
Query: 247 QSREQDLERAGLRQRERRGRRLQEHAERESQ 277
+ ++ E+ G Q E+ ++ ++ E+E Q
Sbjct: 213 EQMQKQEEQMG-EQEEQMRKQEEQMGEQEEQ 242
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 43.9 bits (102), Expect = 2e-04
Identities = 41/126 (32%), Positives = 61/126 (48%), Gaps = 15/126 (11%)
Query: 159 TLWARL------QRERPELLGSFEDVLIRASACLEEAARERDGLEQAL-RRRESEHEREV 211
TLW + R RP GS E R L +A ++ DG ++ R++E E RE
Sbjct: 15 TLWVEVTIPLDFSRRRP---GSQESPRRRG---LGQAHKDADGDDRERNRQKERERRREK 68
Query: 212 RALYEETEQLREQSRRPPSQNFARGERRSRLELELQSREQDLERAGLRQRERRGRRLQEH 271
R ET++ RE+ RR ++ R R R + RE+ +R RQRE+ R Q+
Sbjct: 69 RQTERETDRKRER-RREKDRHRKRDRHRERQRDREKERERQTDRERDRQREKE-RNRQKE 126
Query: 272 AERESQ 277
ERE++
Sbjct: 127 RERETE 132
Score = 43.5 bits (101), Expect = 2e-04
Identities = 33/107 (30%), Positives = 51/107 (47%), Gaps = 8/107 (7%)
Query: 191 RERDGLEQALRRRESEHERE---VRALYEETEQLREQSRRPPSQNFARGERRSRLELELQ 247
R+ DG + R+R++E ERE R +TE+ R++ R R ER + E E +
Sbjct: 141 RQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENK 200
Query: 248 SREQDLERAGLRQRERR-----GRRLQEHAERESQPATATGAAQGAE 289
+ ++ ER R+RER R+ Q ER+ Q T + AE
Sbjct: 201 TEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAE 247
Score = 42.4 bits (98), Expect = 5e-04
Identities = 32/91 (35%), Positives = 49/91 (53%), Gaps = 4/91 (4%)
Query: 193 RDGLEQALRRRESEHEREVRAL--YEETEQLREQSRRPPSQNFARGERRSRLELELQSRE 250
R+G QA R RE E ER+ ++ EE E+ R++ R+ + +R + E E Q RE
Sbjct: 361 REGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQ-RE 419
Query: 251 QDLERAGLRQRER-RGRRLQEHAERESQPAT 280
++ +R R RER R R Q+ ER+ + T
Sbjct: 420 REKDRESERGRERGREREKQKGRERDRERQT 450
Score = 40.8 bits (94), Expect = 0.001
Identities = 29/86 (33%), Positives = 42/86 (48%), Gaps = 2/86 (2%)
Query: 191 RERDGLEQALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRSRLELELQSRE 250
RER+ R RE E ERE R ETE+ RE+ R + +R + + R
Sbjct: 307 RERERERNRKRERERERERE-RERQRETERDREKERERKRKRQTEMDRERNRQTGREGRR 365
Query: 251 Q-DLERAGLRQRERRGRRLQEHAERE 275
Q + ER R+R+R+ R +E ER+
Sbjct: 366 QAERERERERERDRQSAREREERERD 391
Score = 40.8 bits (94), Expect = 0.001
Identities = 33/117 (28%), Positives = 53/117 (45%), Gaps = 18/117 (15%)
Query: 188 EAARERDGLEQALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRSRLE---- 243
E RER+ + R RE E ER+ + +TE RE++R+ + + ER E
Sbjct: 322 ERERERERQRETERDREKERERKRK---RQTEMDRERNRQTGREGRRQAERERERERERD 378
Query: 244 ----LELQSREQDLERAGLRQRERR-------GRRLQEHAERESQPATATGAAQGAE 289
E + RE+D +R ++RER+ R ++ ERE + G +G E
Sbjct: 379 RQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESERGRERGRE 435
Score = 40.4 bits (93), Expect = 0.002
Identities = 32/90 (35%), Positives = 43/90 (47%), Gaps = 9/90 (10%)
Query: 191 RERDGLEQALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRSRLELELQS-- 248
RERD + R R+ E ERE E E R + R+ Q +R + E E Q+
Sbjct: 111 RERDRQREKERNRQKERERET-----EREGERGRDRQTDGQRERERQRDAEKERERQTDR 165
Query: 249 -REQDLERAGLRQRERRGRRLQEHAERESQ 277
R++ ER ++RER R QE ERE Q
Sbjct: 166 ERQRQTERNRQKEREREKNR-QERRERERQ 194
Score = 39.3 bits (90), Expect = 0.004
Identities = 29/79 (36%), Positives = 37/79 (46%), Gaps = 6/79 (7%)
Query: 201 RRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRSRLELELQSR---EQDLERAG 257
R RE E ERE ETE+ R+ R Q ER + E E S E+D ER
Sbjct: 208 RGRERERERETET---ETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERER 264
Query: 258 LRQRERRGRRLQEHAERES 276
R R+R R Q+ ER++
Sbjct: 265 ERDRDRDRDRRQKERERQT 283
Score = 39.3 bits (90), Expect = 0.004
Identities = 26/78 (33%), Positives = 42/78 (53%), Gaps = 4/78 (5%)
Query: 187 EEAARERDGLEQALRRRESEHEREVRALYEETEQLREQSR-RPPSQNFARGERRSRLELE 245
EE R+RD Q R R++E +R+ + ETE+ RE+ + R + RG R + +
Sbjct: 386 EERERDRDRDRQKERERQTEKDRDGQ---RETEKQREREKDRESERGRERGREREKQKGR 442
Query: 246 LQSREQDLERAGLRQRER 263
+ RE+ +R RQR+R
Sbjct: 443 ERDRERQTDRQAGRQRKR 460
Score = 38.1 bits (87), Expect = 0.009
Identities = 25/87 (28%), Positives = 46/87 (52%), Gaps = 8/87 (9%)
Query: 191 RERDGLEQALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRSRLELELQSRE 250
RER+ Q R RE + E+E + +E+ RE+ R ++ +R++ RE
Sbjct: 179 REREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQT-------DRE 231
Query: 251 QDLERAGLRQRERRGRRLQEHAERESQ 277
+D +R R+RE++ R + +ERE++
Sbjct: 232 RDRQRKTEREREKQAER-ERASERETE 257
Score = 38.1 bits (87), Expect = 0.009
Identities = 29/86 (33%), Positives = 42/86 (48%), Gaps = 3/86 (3%)
Query: 192 ERDGLEQALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRSRLELELQSREQ 251
ERD + R R+ E ERE R + E+ RE+ R Q +R E + + R+
Sbjct: 292 ERDRETERKRERQRERERE-RERNRKRERERERERERERQRETERDREKERERK-RKRQT 349
Query: 252 DLERAGLRQRERRGRRLQEHAERESQ 277
+++R RQ R GRR Q ERE +
Sbjct: 350 EMDRERNRQTGREGRR-QAERERERE 374
Score = 38.1 bits (87), Expect = 0.009
Identities = 25/81 (30%), Positives = 40/81 (49%), Gaps = 1/81 (1%)
Query: 188 EAARERDGLEQALRR-RESEHEREVRALYEETEQLREQSRRPPSQNFARGERRSRLELEL 246
++ARER+ E+ R R+ E ER+ + + +Q R + RG R R +
Sbjct: 380 QSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESERGRERGREREKQ 439
Query: 247 QSREQDLERAGLRQRERRGRR 267
+ RE+D ER RQ R+ +R
Sbjct: 440 KGRERDRERQTDRQAGRQRKR 460
Score = 37.7 bits (86), Expect = 0.012
Identities = 30/99 (30%), Positives = 48/99 (48%), Gaps = 7/99 (7%)
Query: 187 EEAARERDGLEQALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRSRLELEL 246
E+ ER+ + RRRE + R+ R + E ++ RE+ R + R +R +
Sbjct: 67 EKRQTERETDRKRERRREKDRHRK-RDRHRERQRDREKERERQTDR-ERDRQREKERNRQ 124
Query: 247 QSREQDLERAGLRQRER-----RGRRLQEHAERESQPAT 280
+ RE++ ER G R R+R R R Q AE+E + T
Sbjct: 125 KERERETEREGERGRDRQTDGQRERERQRDAEKERERQT 163
Score = 37.4 bits (85), Expect = 0.016
Identities = 37/119 (31%), Positives = 58/119 (48%), Gaps = 16/119 (13%)
Query: 163 RLQRERP-ELLGSFEDVLIRASACLEEAARERDGLEQALRRRESEHEREVRALYEETEQL 221
R +RER E ED R S E RER+ + R+R+++ ER+ + +TE+
Sbjct: 188 RRERERQREKENKTED---RHSERGRERERERETETETERKRQTDRERDRQ---RKTERE 241
Query: 222 REQSRRPPSQNFARGERRSRLELELQSREQDLERAGLRQRERRGRRLQEHAERESQPAT 280
RE+ A ER S E E + +E++ ER R R+RR + + +R+ Q T
Sbjct: 242 REKQ--------AERERASERETE-RDKERERERDRDRDRDRRQKERERQTDRKRQRRT 291
Score = 37.0 bits (84), Expect = 0.021
Identities = 33/106 (31%), Positives = 53/106 (50%), Gaps = 16/106 (15%)
Query: 188 EAARERDGLEQALRRRESEHERE-----VRALYEETEQLREQSR---RPPSQNFARGERR 239
E R+R + R+R++E ERE RA ETE+ +E+ R R ++ + ER
Sbjct: 221 ETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERE 280
Query: 240 SRLELELQ---SREQDLERAGLRQRER-----RGRRLQEHAERESQ 277
+ + + Q R+++ ER RQRER R R+ + ERE +
Sbjct: 281 RQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERE 326
Score = 37.0 bits (84), Expect = 0.021
Identities = 33/110 (30%), Positives = 53/110 (48%), Gaps = 8/110 (7%)
Query: 187 EEAARERD-----GLEQALRRRESEHEREVRALYE-ETEQLREQSR-RPPSQNFARGERR 239
+E RERD Q R R+++ +R+ R + ETE+ RE+ R R + R R
Sbjct: 260 KERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRER 319
Query: 240 SRLELELQSREQDLERAGLRQRERRGRRLQEHAERESQPATATGAAQGAE 289
R + R+++ ER ++RER+ R+ Q +RE T + AE
Sbjct: 320 ERERERERERQRETERDREKERERK-RKRQTEMDRERNRQTGREGRRQAE 368
Score = 36.6 bits (83), Expect = 0.027
Identities = 30/91 (32%), Positives = 41/91 (45%), Gaps = 6/91 (6%)
Query: 188 EAARERDGLEQALRRRESEHEREV-RALYEETEQLREQSRRPPSQNFARGERRSRLELEL 246
E +R+ Q R R+ E ERE R E E+ RE+ + ++ RG R R
Sbjct: 160 ERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERE---- 215
Query: 247 QSREQDLERAGLRQRERRGRRLQEHAERESQ 277
+ E + ER RER +R E ERE Q
Sbjct: 216 RETETETERKRQTDRERDRQRKTER-EREKQ 245
Score = 36.6 bits (83), Expect = 0.027
Identities = 27/93 (29%), Positives = 45/93 (48%), Gaps = 6/93 (6%)
Query: 188 EAARERDGLEQALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRSRLELELQ 247
E A ER+ R RE + +R+ +E E+ ++ R+ ++ ER+ + E
Sbjct: 249 ERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRE-- 306
Query: 248 SREQDLERAGLRQRER---RGRRLQEHAERESQ 277
RE++ ER R+RER R R Q ER+ +
Sbjct: 307 -RERERERNRKRERERERERERERQRETERDRE 338
Score = 35.8 bits (81), Expect = 0.046
Identities = 31/95 (32%), Positives = 41/95 (43%), Gaps = 6/95 (6%)
Query: 188 EAARERDGLEQALRRRESEHEREV-RALYEETEQLR----EQSRRPPSQNFARGERRSRL 242
E R R + R RE E +RE R +E E+ R E R Q G R++
Sbjct: 310 ERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAER 369
Query: 243 ELELQSREQDLERAGLRQRERRGRRLQEHAERESQ 277
E E + RE+D + A R+ R R ERE Q
Sbjct: 370 ERE-RERERDRQSAREREERERDRDRDRQKERERQ 403
Score = 34.7 bits (78), Expect = 0.10
Identities = 26/92 (28%), Positives = 44/92 (47%), Gaps = 2/92 (2%)
Query: 188 EAARERDGLEQALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRSRLELELQ 247
E ER+ + R+ E ERE + + +E+ R+ + R ER E + +
Sbjct: 243 EKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRE 302
Query: 248 -SREQDLERAGLRQRER-RGRRLQEHAERESQ 277
RE++ ER R+RER R R + +RE++
Sbjct: 303 RQRERERERERNRKRERERERERERERQRETE 334
Score = 34.7 bits (78), Expect = 0.10
Identities = 26/91 (28%), Positives = 45/91 (49%), Gaps = 2/91 (2%)
Query: 188 EAARERDGLEQALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRSRLELELQ 247
E RER+ RR++E ERE R + + RE+ R ++ R + R R + +
Sbjct: 350 EMDRERNRQTGREGRRQAERERE-RERERDRQSAREREERERDRDRDRQKERERQTEKDR 408
Query: 248 SREQDLERAGLRQRERRGRRLQEHA-ERESQ 277
+++ E+ R+++R R +E ERE Q
Sbjct: 409 DGQRETEKQREREKDRESERGRERGREREKQ 439
Score = 34.3 bits (77), Expect = 0.13
Identities = 27/89 (30%), Positives = 43/89 (48%), Gaps = 3/89 (3%)
Query: 191 RERDGLEQALRRRESEHEREV-RALYEETEQLREQSRRPPSQNFARGERRSRLELELQSR 249
R+RD + R RE E ER+ R + E+ R + + + GER + + Q R
Sbjct: 89 RKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQ-R 147
Query: 250 EQDLERAGLRQRERR-GRRLQEHAERESQ 277
E++ +R ++RER+ R Q ER Q
Sbjct: 148 ERERQRDAEKERERQTDRERQRQTERNRQ 176
Score = 33.9 bits (76), Expect = 0.18
Identities = 23/91 (25%), Positives = 46/91 (50%), Gaps = 2/91 (2%)
Query: 188 EAARERDGLEQALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRSRLELELQ 247
E ERD + R R+ + +R + +T++ R++ + + ER+ E E +
Sbjct: 253 ERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERE 312
Query: 248 -SREQDLERAGLRQRERRGRRLQEHAERESQ 277
+R+++ ER R+RER+ R + E+E +
Sbjct: 313 RNRKRERERERERERERQ-RETERDREKERE 342
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 43.1 bits (100), Expect = 3e-04
Identities = 34/109 (31%), Positives = 53/109 (48%), Gaps = 14/109 (12%)
Query: 164 LQRERPELLGSFEDVLIRASACLEEAARERDGLEQ----------ALRRRESEHEREVRA 213
+++E+ +L F+D + +A EE R++ +EQ RRR+ E E VR
Sbjct: 2509 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2568
Query: 214 LYEETEQLREQSRRPPSQNFARGERRSRLELELQSREQDLERAGLRQRE 262
EE +QL EQ RR + A +R R +L+L ++ RA L E
Sbjct: 2569 KQEELQQL-EQQRRQQEELLAEENQRLREQLQLL---EEQHRAALAHSE 2613
Score = 41.6 bits (96), Expect = 8e-04
Identities = 31/99 (31%), Positives = 49/99 (49%), Gaps = 4/99 (4%)
Query: 181 RASACLEEAARERDGLEQALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRS 240
RA LEE + + E+ LR+ E E R+V+ E ++ E + +FA E+ +
Sbjct: 1533 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFA--EKTA 1590
Query: 241 RLELELQSREQDLERAGLRQRERRGRRLQEHAERESQPA 279
+LE LQ E+ + A LR+ R + Q AER + A
Sbjct: 1591 QLERSLQ--EEHVAVAQLREEAERRAQQQAEAERAREEA 1627
Score = 40.4 bits (93), Expect = 0.002
Identities = 53/190 (27%), Positives = 78/190 (41%), Gaps = 22/190 (11%)
Query: 104 ANPCRTPEE---TFESGGLDVQGTAGSLDEEEEEEERFHTVLEQLGVAPVLGKQRAVRTL 160
A+ R EE T E ++ AG E EE R + E+ L ++ A R
Sbjct: 1769 ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ- 1827
Query: 161 WARLQRERPELLGSFEDVLIRASACLEEAARERDGLEQALRRRESEHEREVRALYEETEQ 220
R + ER VL A + EA R + E AL+ +E+E+ER R +E Q
Sbjct: 1828 --RAEAER---------VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1876
Query: 221 LREQSRRPPSQNFARGERRSRLELELQSREQDLER-AGLRQRERRGRRLQEH---AERES 276
R + ER ++L ++ + +LER GL + R RR E A + S
Sbjct: 1877 RRRLEEQAAQHKADIEERLAQLR---KASDSELERQKGLVEDTLRQRRQVEEEILALKAS 1933
Query: 277 QPATATGAAQ 286
A G A+
Sbjct: 1934 FEKAAAGKAE 1943
Score = 39.3 bits (90), Expect = 0.004
Identities = 72/315 (22%), Positives = 118/315 (37%), Gaps = 39/315 (12%)
Query: 9 ADEAQEEEGELEGGSAGPRAAILEQAEELFLLCDKEAKGFITKHDLQGLQSDLPLTPEQL 68
A+E ++ E +A R A LE+ E L ++ + + + Q L L E
Sbjct: 1986 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR--LRERAEQESARQLQLAQEAA 2043
Query: 69 EAVFESLDRAHTGFLTAREFCLG---------LGMFVGVASAQGANPCRTPEETFESGGL 119
+ ++ ++AH + +E L L G A A R E E +
Sbjct: 2044 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA-----ARRAAEEAEEARV 2098
Query: 120 DVQGTAGSLDEEEEEEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPELLGSFEDVL 179
+ A + EE ER E+ A Q A L ++E + + L
Sbjct: 2099 QAEREAAQSRRQVEEAERLKQSAEEQAQARAQA-QAAAEKLRKEAEQEAARRAQAEQAAL 2157
Query: 180 IRASACLEEAARERDGLEQALRRRESEHEREVRAL---YEETEQ----LREQSRRPPSQN 232
+ A E + + EQ LR++ ++ E+E+ L EET+ L E+ +R ++
Sbjct: 2158 RQKQAADAEMEKHKKFAEQTLRQK-AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2216
Query: 233 FARGERRSRLELELQSREQDLERAG--------------LRQRERRGRRLQEHAERESQP 278
+RS++E EL S +E LR ++ R LQE AE+ Q
Sbjct: 2217 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2276
Query: 279 ATATGAAQGAEYTAA 293
A A AA
Sbjct: 2277 AEEAARLSVAAQEAA 2291
Score = 37.4 bits (85), Expect = 0.016
Identities = 40/158 (25%), Positives = 67/158 (42%), Gaps = 7/158 (4%)
Query: 134 EEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPELLGSFEDVLIRASACLEEAARER 193
EEER E+ + ++ A R A L+ E L E+ +E+AR+
Sbjct: 1978 EEERRRREAEERVQKSLAAEEEAARQRKAALE-EVERLKAKVEEARRLRERAEQESARQL 2036
Query: 194 DGLEQALRRR----ESEHEREVRALYEETEQL--REQSRRPPSQNFARGERRSRLELELQ 247
++A ++R E H V+ +E +Q +EQS + A RR+ E E
Sbjct: 2037 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2096
Query: 248 SREQDLERAGLRQRERRGRRLQEHAERESQPATATGAA 285
+ + E A R++ RL++ AE ++Q AA
Sbjct: 2097 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2134
Score = 36.6 bits (83), Expect = 0.027
Identities = 39/127 (30%), Positives = 55/127 (43%), Gaps = 26/127 (20%)
Query: 162 ARLQRERPELLGSFEDVLIRASACLEEAARERDGLEQALRRRESEHEREVRALYEETEQL 221
A L+ E + + ED L EAAR+R + RRR ER ++L E E
Sbjct: 1942 AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 2001
Query: 222 REQSRRPPSQNFARGERRSRLELELQSREQDLERAGLRQRERRGRRLQEHAERES--QPA 279
R +R++ LE ++ER L+ + RRL+E AE+ES Q
Sbjct: 2002 R--------------QRKAALE--------EVER--LKAKVEEARRLRERAEQESARQLQ 2037
Query: 280 TATGAAQ 286
A AAQ
Sbjct: 2038 LAQEAAQ 2044
Score = 35.0 bits (79), Expect = 0.079
Identities = 43/145 (29%), Positives = 66/145 (45%), Gaps = 15/145 (10%)
Query: 153 KQRAVRTLWA-RLQRERPE--LLGSFEDVLIRASACLEEAARERDGLEQALRRRESEHER 209
KQRA++ L RLQ E E L + + + LE A R + Q+ R +E
Sbjct: 1531 KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA 1590
Query: 210 EV-RALYEE---TEQLREQSRRPPSQNFARGERRSRLELELQSREQDLERAGLRQRERRG 265
++ R+L EE QLRE++ R R ++++ E + E++LER L+ E
Sbjct: 1591 QLERSLQEEHVAVAQLREEAER-------RAQQQAEAERAREEAERELERWQLKANEALR 1643
Query: 266 RRLQ-EHAERESQPATATGAAQGAE 289
RLQ E ++ A A Q E
Sbjct: 1644 LRLQAEEVAQQKSLAQAEAEKQKEE 1668
Score = 35.0 bits (79), Expect = 0.079
Identities = 35/135 (25%), Positives = 55/135 (40%), Gaps = 8/135 (5%)
Query: 153 KQRAVRTL--WARLQRERPELLGSFEDVLIRASACLEEAARERDGLEQALRRRESEHERE 210
++ A R L W E L E+V + S EA ++++ E+ RRR E+
Sbjct: 1624 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1683
Query: 211 VR---ALYEETEQLREQSRRPPSQNFARGERRSRLELELQSREQD---LERAGLRQRERR 264
VR +E E+ R+ + Q A + RL E + EQ LE R +
Sbjct: 1684 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1743
Query: 265 GRRLQEHAERESQPA 279
Q+ E E++ A
Sbjct: 1744 AAATQKRQELEAELA 1758
Score = 31.6 bits (70), Expect = 0.87
Identities = 26/118 (22%), Positives = 57/118 (48%), Gaps = 5/118 (4%)
Query: 164 LQRERPELLGSFEDVLIRASACLEEA-ARERDGLEQALRRRESEHEREVRALYEET---E 219
LQ + E+ ++ L++ + L+++ E+D L Q R E E + + +E +
Sbjct: 2469 LQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ 2528
Query: 220 QLREQSRRPPSQNFARGERRSRLELELQSREQDLERAGLRQRERRGRRLQEHAERESQ 277
QLRE+ +R Q + +R +E R Q G+R+++ ++L++ ++ +
Sbjct: 2529 QLREEQQR-QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEE 2585
Score = 28.1 bits (61), Expect = 9.6
Identities = 31/128 (24%), Positives = 54/128 (42%), Gaps = 15/128 (11%)
Query: 164 LQRERPELLGSFEDVLIRASACLEEAARERDGLEQALRRRESEHEREVRALYEETEQLRE 223
LQRER + + A LE+ ++ Q LR + ++++ + E
Sbjct: 2503 LQRER---------FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2553
Query: 224 QSRR--PPSQNFARGERRSRLELELQSREQDLERAGLRQRERRGRRLQEHAER----ESQ 277
++RR ++ R ++ +LE Q R+Q+ A QR R +L E R S+
Sbjct: 2554 EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSE 2613
Query: 278 PATATGAA 285
TA+ A
Sbjct: 2614 EVTASQVA 2621
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 43.1 bits (100), Expect = 3e-04
Identities = 34/109 (31%), Positives = 53/109 (48%), Gaps = 14/109 (12%)
Query: 164 LQRERPELLGSFEDVLIRASACLEEAARERDGLEQ----------ALRRRESEHEREVRA 213
+++E+ +L F+D + +A EE R++ +EQ RRR+ E E VR
Sbjct: 2513 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2572
Query: 214 LYEETEQLREQSRRPPSQNFARGERRSRLELELQSREQDLERAGLRQRE 262
EE +QL EQ RR + A +R R +L+L ++ RA L E
Sbjct: 2573 KQEELQQL-EQQRRQQEELLAEENQRLREQLQLL---EEQHRAALAHSE 2617
Score = 41.6 bits (96), Expect = 8e-04
Identities = 31/99 (31%), Positives = 49/99 (49%), Gaps = 4/99 (4%)
Query: 181 RASACLEEAARERDGLEQALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRS 240
RA LEE + + E+ LR+ E E R+V+ E ++ E + +FA E+ +
Sbjct: 1537 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFA--EKTA 1594
Query: 241 RLELELQSREQDLERAGLRQRERRGRRLQEHAERESQPA 279
+LE LQ E+ + A LR+ R + Q AER + A
Sbjct: 1595 QLERSLQ--EEHVAVAQLREEAERRAQQQAEAERAREEA 1631
Score = 40.4 bits (93), Expect = 0.002
Identities = 53/190 (27%), Positives = 78/190 (41%), Gaps = 22/190 (11%)
Query: 104 ANPCRTPEE---TFESGGLDVQGTAGSLDEEEEEEERFHTVLEQLGVAPVLGKQRAVRTL 160
A+ R EE T E ++ AG E EE R + E+ L ++ A R
Sbjct: 1773 ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ- 1831
Query: 161 WARLQRERPELLGSFEDVLIRASACLEEAARERDGLEQALRRRESEHEREVRALYEETEQ 220
R + ER VL A + EA R + E AL+ +E+E+ER R +E Q
Sbjct: 1832 --RAEAER---------VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1880
Query: 221 LREQSRRPPSQNFARGERRSRLELELQSREQDLER-AGLRQRERRGRRLQEH---AERES 276
R + ER ++L ++ + +LER GL + R RR E A + S
Sbjct: 1881 RRRLEEQAAQHKADIEERLAQLR---KASDSELERQKGLVEDTLRQRRQVEEEILALKAS 1937
Query: 277 QPATATGAAQ 286
A G A+
Sbjct: 1938 FEKAAAGKAE 1947
Score = 39.3 bits (90), Expect = 0.004
Identities = 72/315 (22%), Positives = 118/315 (37%), Gaps = 39/315 (12%)
Query: 9 ADEAQEEEGELEGGSAGPRAAILEQAEELFLLCDKEAKGFITKHDLQGLQSDLPLTPEQL 68
A+E ++ E +A R A LE+ E L ++ + + + Q L L E
Sbjct: 1990 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR--LRERAEQESARQLQLAQEAA 2047
Query: 69 EAVFESLDRAHTGFLTAREFCLG---------LGMFVGVASAQGANPCRTPEETFESGGL 119
+ ++ ++AH + +E L L G A A R E E +
Sbjct: 2048 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA-----ARRAAEEAEEARV 2102
Query: 120 DVQGTAGSLDEEEEEEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPELLGSFEDVL 179
+ A + EE ER E+ A Q A L ++E + + L
Sbjct: 2103 QAEREAAQSRRQVEEAERLKQSAEEQAQARAQA-QAAAEKLRKEAEQEAARRAQAEQAAL 2161
Query: 180 IRASACLEEAARERDGLEQALRRRESEHEREVRAL---YEETEQ----LREQSRRPPSQN 232
+ A E + + EQ LR++ ++ E+E+ L EET+ L E+ +R ++
Sbjct: 2162 RQKQAADAEMEKHKKFAEQTLRQK-AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2220
Query: 233 FARGERRSRLELELQSREQDLERAG--------------LRQRERRGRRLQEHAERESQP 278
+RS++E EL S +E LR ++ R LQE AE+ Q
Sbjct: 2221 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2280
Query: 279 ATATGAAQGAEYTAA 293
A A AA
Sbjct: 2281 AEEAARLSVAAQEAA 2295
Score = 37.4 bits (85), Expect = 0.016
Identities = 40/158 (25%), Positives = 67/158 (42%), Gaps = 7/158 (4%)
Query: 134 EEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPELLGSFEDVLIRASACLEEAARER 193
EEER E+ + ++ A R A L+ E L E+ +E+AR+
Sbjct: 1982 EEERRRREAEERVQKSLAAEEEAARQRKAALE-EVERLKAKVEEARRLRERAEQESARQL 2040
Query: 194 DGLEQALRRR----ESEHEREVRALYEETEQL--REQSRRPPSQNFARGERRSRLELELQ 247
++A ++R E H V+ +E +Q +EQS + A RR+ E E
Sbjct: 2041 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2100
Query: 248 SREQDLERAGLRQRERRGRRLQEHAERESQPATATGAA 285
+ + E A R++ RL++ AE ++Q AA
Sbjct: 2101 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2138
Score = 36.6 bits (83), Expect = 0.027
Identities = 39/127 (30%), Positives = 55/127 (43%), Gaps = 26/127 (20%)
Query: 162 ARLQRERPELLGSFEDVLIRASACLEEAARERDGLEQALRRRESEHEREVRALYEETEQL 221
A L+ E + + ED L EAAR+R + RRR ER ++L E E
Sbjct: 1946 AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 2005
Query: 222 REQSRRPPSQNFARGERRSRLELELQSREQDLERAGLRQRERRGRRLQEHAERES--QPA 279
R +R++ LE ++ER L+ + RRL+E AE+ES Q
Sbjct: 2006 R--------------QRKAALE--------EVER--LKAKVEEARRLRERAEQESARQLQ 2041
Query: 280 TATGAAQ 286
A AAQ
Sbjct: 2042 LAQEAAQ 2048
Score = 35.0 bits (79), Expect = 0.079
Identities = 43/145 (29%), Positives = 66/145 (45%), Gaps = 15/145 (10%)
Query: 153 KQRAVRTLWA-RLQRERPE--LLGSFEDVLIRASACLEEAARERDGLEQALRRRESEHER 209
KQRA++ L RLQ E E L + + + LE A R + Q+ R +E
Sbjct: 1535 KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA 1594
Query: 210 EV-RALYEE---TEQLREQSRRPPSQNFARGERRSRLELELQSREQDLERAGLRQRERRG 265
++ R+L EE QLRE++ R R ++++ E + E++LER L+ E
Sbjct: 1595 QLERSLQEEHVAVAQLREEAER-------RAQQQAEAERAREEAERELERWQLKANEALR 1647
Query: 266 RRLQ-EHAERESQPATATGAAQGAE 289
RLQ E ++ A A Q E
Sbjct: 1648 LRLQAEEVAQQKSLAQAEAEKQKEE 1672
Score = 35.0 bits (79), Expect = 0.079
Identities = 35/135 (25%), Positives = 55/135 (40%), Gaps = 8/135 (5%)
Query: 153 KQRAVRTL--WARLQRERPELLGSFEDVLIRASACLEEAARERDGLEQALRRRESEHERE 210
++ A R L W E L E+V + S EA ++++ E+ RRR E+
Sbjct: 1628 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1687
Query: 211 VR---ALYEETEQLREQSRRPPSQNFARGERRSRLELELQSREQD---LERAGLRQRERR 264
VR +E E+ R+ + Q A + RL E + EQ LE R +
Sbjct: 1688 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1747
Query: 265 GRRLQEHAERESQPA 279
Q+ E E++ A
Sbjct: 1748 AAATQKRQELEAELA 1762
Score = 31.6 bits (70), Expect = 0.87
Identities = 26/118 (22%), Positives = 57/118 (48%), Gaps = 5/118 (4%)
Query: 164 LQRERPELLGSFEDVLIRASACLEEA-ARERDGLEQALRRRESEHEREVRALYEET---E 219
LQ + E+ ++ L++ + L+++ E+D L Q R E E + + +E +
Sbjct: 2473 LQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ 2532
Query: 220 QLREQSRRPPSQNFARGERRSRLELELQSREQDLERAGLRQRERRGRRLQEHAERESQ 277
QLRE+ +R Q + +R +E R Q G+R+++ ++L++ ++ +
Sbjct: 2533 QLREEQQR-QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEE 2589
Score = 28.1 bits (61), Expect = 9.6
Identities = 31/128 (24%), Positives = 54/128 (42%), Gaps = 15/128 (11%)
Query: 164 LQRERPELLGSFEDVLIRASACLEEAARERDGLEQALRRRESEHEREVRALYEETEQLRE 223
LQRER + + A LE+ ++ Q LR + ++++ + E
Sbjct: 2507 LQRER---------FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2557
Query: 224 QSRR--PPSQNFARGERRSRLELELQSREQDLERAGLRQRERRGRRLQEHAER----ESQ 277
++RR ++ R ++ +LE Q R+Q+ A QR R +L E R S+
Sbjct: 2558 EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSE 2617
Query: 278 PATATGAA 285
TA+ A
Sbjct: 2618 EVTASQVA 2625
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 43.1 bits (100), Expect = 3e-04
Identities = 34/109 (31%), Positives = 53/109 (48%), Gaps = 14/109 (12%)
Query: 164 LQRERPELLGSFEDVLIRASACLEEAARERDGLEQ----------ALRRRESEHEREVRA 213
+++E+ +L F+D + +A EE R++ +EQ RRR+ E E VR
Sbjct: 2509 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2568
Query: 214 LYEETEQLREQSRRPPSQNFARGERRSRLELELQSREQDLERAGLRQRE 262
EE +QL EQ RR + A +R R +L+L ++ RA L E
Sbjct: 2569 KQEELQQL-EQQRRQQEELLAEENQRLREQLQLL---EEQHRAALAHSE 2613
Score = 41.6 bits (96), Expect = 8e-04
Identities = 31/99 (31%), Positives = 49/99 (49%), Gaps = 4/99 (4%)
Query: 181 RASACLEEAARERDGLEQALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRS 240
RA LEE + + E+ LR+ E E R+V+ E ++ E + +FA E+ +
Sbjct: 1533 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFA--EKTA 1590
Query: 241 RLELELQSREQDLERAGLRQRERRGRRLQEHAERESQPA 279
+LE LQ E+ + A LR+ R + Q AER + A
Sbjct: 1591 QLERSLQ--EEHVAVAQLREEAERRAQQQAEAERAREEA 1627
Score = 40.4 bits (93), Expect = 0.002
Identities = 53/190 (27%), Positives = 78/190 (41%), Gaps = 22/190 (11%)
Query: 104 ANPCRTPEE---TFESGGLDVQGTAGSLDEEEEEEERFHTVLEQLGVAPVLGKQRAVRTL 160
A+ R EE T E ++ AG E EE R + E+ L ++ A R
Sbjct: 1769 ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ- 1827
Query: 161 WARLQRERPELLGSFEDVLIRASACLEEAARERDGLEQALRRRESEHEREVRALYEETEQ 220
R + ER VL A + EA R + E AL+ +E+E+ER R +E Q
Sbjct: 1828 --RAEAER---------VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1876
Query: 221 LREQSRRPPSQNFARGERRSRLELELQSREQDLER-AGLRQRERRGRRLQEH---AERES 276
R + ER ++L ++ + +LER GL + R RR E A + S
Sbjct: 1877 RRRLEEQAAQHKADIEERLAQLR---KASDSELERQKGLVEDTLRQRRQVEEEILALKAS 1933
Query: 277 QPATATGAAQ 286
A G A+
Sbjct: 1934 FEKAAAGKAE 1943
Score = 39.3 bits (90), Expect = 0.004
Identities = 72/315 (22%), Positives = 118/315 (37%), Gaps = 39/315 (12%)
Query: 9 ADEAQEEEGELEGGSAGPRAAILEQAEELFLLCDKEAKGFITKHDLQGLQSDLPLTPEQL 68
A+E ++ E +A R A LE+ E L ++ + + + Q L L E
Sbjct: 1986 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR--LRERAEQESARQLQLAQEAA 2043
Query: 69 EAVFESLDRAHTGFLTAREFCLG---------LGMFVGVASAQGANPCRTPEETFESGGL 119
+ ++ ++AH + +E L L G A A R E E +
Sbjct: 2044 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA-----ARRAAEEAEEARV 2098
Query: 120 DVQGTAGSLDEEEEEEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPELLGSFEDVL 179
+ A + EE ER E+ A Q A L ++E + + L
Sbjct: 2099 QAEREAAQSRRQVEEAERLKQSAEEQAQARAQA-QAAAEKLRKEAEQEAARRAQAEQAAL 2157
Query: 180 IRASACLEEAARERDGLEQALRRRESEHEREVRAL---YEETEQ----LREQSRRPPSQN 232
+ A E + + EQ LR++ ++ E+E+ L EET+ L E+ +R ++
Sbjct: 2158 RQKQAADAEMEKHKKFAEQTLRQK-AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2216
Query: 233 FARGERRSRLELELQSREQDLERAG--------------LRQRERRGRRLQEHAERESQP 278
+RS++E EL S +E LR ++ R LQE AE+ Q
Sbjct: 2217 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2276
Query: 279 ATATGAAQGAEYTAA 293
A A AA
Sbjct: 2277 AEEAARLSVAAQEAA 2291
Score = 37.4 bits (85), Expect = 0.016
Identities = 40/158 (25%), Positives = 67/158 (42%), Gaps = 7/158 (4%)
Query: 134 EEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPELLGSFEDVLIRASACLEEAARER 193
EEER E+ + ++ A R A L+ E L E+ +E+AR+
Sbjct: 1978 EEERRRREAEERVQKSLAAEEEAARQRKAALE-EVERLKAKVEEARRLRERAEQESARQL 2036
Query: 194 DGLEQALRRR----ESEHEREVRALYEETEQL--REQSRRPPSQNFARGERRSRLELELQ 247
++A ++R E H V+ +E +Q +EQS + A RR+ E E
Sbjct: 2037 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2096
Query: 248 SREQDLERAGLRQRERRGRRLQEHAERESQPATATGAA 285
+ + E A R++ RL++ AE ++Q AA
Sbjct: 2097 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2134
Score = 36.6 bits (83), Expect = 0.027
Identities = 39/127 (30%), Positives = 55/127 (43%), Gaps = 26/127 (20%)
Query: 162 ARLQRERPELLGSFEDVLIRASACLEEAARERDGLEQALRRRESEHEREVRALYEETEQL 221
A L+ E + + ED L EAAR+R + RRR ER ++L E E
Sbjct: 1942 AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 2001
Query: 222 REQSRRPPSQNFARGERRSRLELELQSREQDLERAGLRQRERRGRRLQEHAERES--QPA 279
R +R++ LE ++ER L+ + RRL+E AE+ES Q
Sbjct: 2002 R--------------QRKAALE--------EVER--LKAKVEEARRLRERAEQESARQLQ 2037
Query: 280 TATGAAQ 286
A AAQ
Sbjct: 2038 LAQEAAQ 2044
Score = 35.0 bits (79), Expect = 0.079
Identities = 43/145 (29%), Positives = 66/145 (45%), Gaps = 15/145 (10%)
Query: 153 KQRAVRTLWA-RLQRERPE--LLGSFEDVLIRASACLEEAARERDGLEQALRRRESEHER 209
KQRA++ L RLQ E E L + + + LE A R + Q+ R +E
Sbjct: 1531 KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA 1590
Query: 210 EV-RALYEE---TEQLREQSRRPPSQNFARGERRSRLELELQSREQDLERAGLRQRERRG 265
++ R+L EE QLRE++ R R ++++ E + E++LER L+ E
Sbjct: 1591 QLERSLQEEHVAVAQLREEAER-------RAQQQAEAERAREEAERELERWQLKANEALR 1643
Query: 266 RRLQ-EHAERESQPATATGAAQGAE 289
RLQ E ++ A A Q E
Sbjct: 1644 LRLQAEEVAQQKSLAQAEAEKQKEE 1668
Score = 35.0 bits (79), Expect = 0.079
Identities = 35/135 (25%), Positives = 55/135 (40%), Gaps = 8/135 (5%)
Query: 153 KQRAVRTL--WARLQRERPELLGSFEDVLIRASACLEEAARERDGLEQALRRRESEHERE 210
++ A R L W E L E+V + S EA ++++ E+ RRR E+
Sbjct: 1624 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1683
Query: 211 VR---ALYEETEQLREQSRRPPSQNFARGERRSRLELELQSREQD---LERAGLRQRERR 264
VR +E E+ R+ + Q A + RL E + EQ LE R +
Sbjct: 1684 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1743
Query: 265 GRRLQEHAERESQPA 279
Q+ E E++ A
Sbjct: 1744 AAATQKRQELEAELA 1758
Score = 31.6 bits (70), Expect = 0.87
Identities = 26/118 (22%), Positives = 57/118 (48%), Gaps = 5/118 (4%)
Query: 164 LQRERPELLGSFEDVLIRASACLEEA-ARERDGLEQALRRRESEHEREVRALYEET---E 219
LQ + E+ ++ L++ + L+++ E+D L Q R E E + + +E +
Sbjct: 2469 LQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ 2528
Query: 220 QLREQSRRPPSQNFARGERRSRLELELQSREQDLERAGLRQRERRGRRLQEHAERESQ 277
QLRE+ +R Q + +R +E R Q G+R+++ ++L++ ++ +
Sbjct: 2529 QLREEQQR-QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEE 2585
Score = 28.1 bits (61), Expect = 9.6
Identities = 31/128 (24%), Positives = 54/128 (42%), Gaps = 15/128 (11%)
Query: 164 LQRERPELLGSFEDVLIRASACLEEAARERDGLEQALRRRESEHEREVRALYEETEQLRE 223
LQRER + + A LE+ ++ Q LR + ++++ + E
Sbjct: 2503 LQRER---------FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2553
Query: 224 QSRR--PPSQNFARGERRSRLELELQSREQDLERAGLRQRERRGRRLQEHAER----ESQ 277
++RR ++ R ++ +LE Q R+Q+ A QR R +L E R S+
Sbjct: 2554 EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSE 2613
Query: 278 PATATGAA 285
TA+ A
Sbjct: 2614 EVTASQVA 2621
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 43.1 bits (100), Expect = 3e-04
Identities = 34/109 (31%), Positives = 53/109 (48%), Gaps = 14/109 (12%)
Query: 164 LQRERPELLGSFEDVLIRASACLEEAARERDGLEQ----------ALRRRESEHEREVRA 213
+++E+ +L F+D + +A EE R++ +EQ RRR+ E E VR
Sbjct: 2477 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2536
Query: 214 LYEETEQLREQSRRPPSQNFARGERRSRLELELQSREQDLERAGLRQRE 262
EE +QL EQ RR + A +R R +L+L ++ RA L E
Sbjct: 2537 KQEELQQL-EQQRRQQEELLAEENQRLREQLQLL---EEQHRAALAHSE 2581
Score = 41.6 bits (96), Expect = 8e-04
Identities = 31/99 (31%), Positives = 49/99 (49%), Gaps = 4/99 (4%)
Query: 181 RASACLEEAARERDGLEQALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRS 240
RA LEE + + E+ LR+ E E R+V+ E ++ E + +FA E+ +
Sbjct: 1501 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFA--EKTA 1558
Query: 241 RLELELQSREQDLERAGLRQRERRGRRLQEHAERESQPA 279
+LE LQ E+ + A LR+ R + Q AER + A
Sbjct: 1559 QLERSLQ--EEHVAVAQLREEAERRAQQQAEAERAREEA 1595
Score = 40.4 bits (93), Expect = 0.002
Identities = 53/190 (27%), Positives = 78/190 (41%), Gaps = 22/190 (11%)
Query: 104 ANPCRTPEE---TFESGGLDVQGTAGSLDEEEEEEERFHTVLEQLGVAPVLGKQRAVRTL 160
A+ R EE T E ++ AG E EE R + E+ L ++ A R
Sbjct: 1737 ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ- 1795
Query: 161 WARLQRERPELLGSFEDVLIRASACLEEAARERDGLEQALRRRESEHEREVRALYEETEQ 220
R + ER VL A + EA R + E AL+ +E+E+ER R +E Q
Sbjct: 1796 --RAEAER---------VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1844
Query: 221 LREQSRRPPSQNFARGERRSRLELELQSREQDLER-AGLRQRERRGRRLQEH---AERES 276
R + ER ++L ++ + +LER GL + R RR E A + S
Sbjct: 1845 RRRLEEQAAQHKADIEERLAQLR---KASDSELERQKGLVEDTLRQRRQVEEEILALKAS 1901
Query: 277 QPATATGAAQ 286
A G A+
Sbjct: 1902 FEKAAAGKAE 1911
Score = 39.3 bits (90), Expect = 0.004
Identities = 72/315 (22%), Positives = 118/315 (37%), Gaps = 39/315 (12%)
Query: 9 ADEAQEEEGELEGGSAGPRAAILEQAEELFLLCDKEAKGFITKHDLQGLQSDLPLTPEQL 68
A+E ++ E +A R A LE+ E L ++ + + + Q L L E
Sbjct: 1954 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR--LRERAEQESARQLQLAQEAA 2011
Query: 69 EAVFESLDRAHTGFLTAREFCLG---------LGMFVGVASAQGANPCRTPEETFESGGL 119
+ ++ ++AH + +E L L G A A R E E +
Sbjct: 2012 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA-----ARRAAEEAEEARV 2066
Query: 120 DVQGTAGSLDEEEEEEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPELLGSFEDVL 179
+ A + EE ER E+ A Q A L ++E + + L
Sbjct: 2067 QAEREAAQSRRQVEEAERLKQSAEEQAQARAQA-QAAAEKLRKEAEQEAARRAQAEQAAL 2125
Query: 180 IRASACLEEAARERDGLEQALRRRESEHEREVRAL---YEETEQ----LREQSRRPPSQN 232
+ A E + + EQ LR++ ++ E+E+ L EET+ L E+ +R ++
Sbjct: 2126 RQKQAADAEMEKHKKFAEQTLRQK-AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2184
Query: 233 FARGERRSRLELELQSREQDLERAG--------------LRQRERRGRRLQEHAERESQP 278
+RS++E EL S +E LR ++ R LQE AE+ Q
Sbjct: 2185 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2244
Query: 279 ATATGAAQGAEYTAA 293
A A AA
Sbjct: 2245 AEEAARLSVAAQEAA 2259
Score = 37.4 bits (85), Expect = 0.016
Identities = 40/158 (25%), Positives = 67/158 (42%), Gaps = 7/158 (4%)
Query: 134 EEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPELLGSFEDVLIRASACLEEAARER 193
EEER E+ + ++ A R A L+ E L E+ +E+AR+
Sbjct: 1946 EEERRRREAEERVQKSLAAEEEAARQRKAALE-EVERLKAKVEEARRLRERAEQESARQL 2004
Query: 194 DGLEQALRRR----ESEHEREVRALYEETEQL--REQSRRPPSQNFARGERRSRLELELQ 247
++A ++R E H V+ +E +Q +EQS + A RR+ E E
Sbjct: 2005 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2064
Query: 248 SREQDLERAGLRQRERRGRRLQEHAERESQPATATGAA 285
+ + E A R++ RL++ AE ++Q AA
Sbjct: 2065 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2102
Score = 36.6 bits (83), Expect = 0.027
Identities = 39/127 (30%), Positives = 55/127 (43%), Gaps = 26/127 (20%)
Query: 162 ARLQRERPELLGSFEDVLIRASACLEEAARERDGLEQALRRRESEHEREVRALYEETEQL 221
A L+ E + + ED L EAAR+R + RRR ER ++L E E
Sbjct: 1910 AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 1969
Query: 222 REQSRRPPSQNFARGERRSRLELELQSREQDLERAGLRQRERRGRRLQEHAERES--QPA 279
R +R++ LE ++ER L+ + RRL+E AE+ES Q
Sbjct: 1970 R--------------QRKAALE--------EVER--LKAKVEEARRLRERAEQESARQLQ 2005
Query: 280 TATGAAQ 286
A AAQ
Sbjct: 2006 LAQEAAQ 2012
Score = 35.0 bits (79), Expect = 0.079
Identities = 43/145 (29%), Positives = 66/145 (45%), Gaps = 15/145 (10%)
Query: 153 KQRAVRTLWA-RLQRERPE--LLGSFEDVLIRASACLEEAARERDGLEQALRRRESEHER 209
KQRA++ L RLQ E E L + + + LE A R + Q+ R +E
Sbjct: 1499 KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA 1558
Query: 210 EV-RALYEE---TEQLREQSRRPPSQNFARGERRSRLELELQSREQDLERAGLRQRERRG 265
++ R+L EE QLRE++ R R ++++ E + E++LER L+ E
Sbjct: 1559 QLERSLQEEHVAVAQLREEAER-------RAQQQAEAERAREEAERELERWQLKANEALR 1611
Query: 266 RRLQ-EHAERESQPATATGAAQGAE 289
RLQ E ++ A A Q E
Sbjct: 1612 LRLQAEEVAQQKSLAQAEAEKQKEE 1636
Score = 35.0 bits (79), Expect = 0.079
Identities = 35/135 (25%), Positives = 55/135 (40%), Gaps = 8/135 (5%)
Query: 153 KQRAVRTL--WARLQRERPELLGSFEDVLIRASACLEEAARERDGLEQALRRRESEHERE 210
++ A R L W E L E+V + S EA ++++ E+ RRR E+
Sbjct: 1592 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1651
Query: 211 VR---ALYEETEQLREQSRRPPSQNFARGERRSRLELELQSREQD---LERAGLRQRERR 264
VR +E E+ R+ + Q A + RL E + EQ LE R +
Sbjct: 1652 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1711
Query: 265 GRRLQEHAERESQPA 279
Q+ E E++ A
Sbjct: 1712 AAATQKRQELEAELA 1726
Score = 31.6 bits (70), Expect = 0.87
Identities = 26/118 (22%), Positives = 57/118 (48%), Gaps = 5/118 (4%)
Query: 164 LQRERPELLGSFEDVLIRASACLEEA-ARERDGLEQALRRRESEHEREVRALYEET---E 219
LQ + E+ ++ L++ + L+++ E+D L Q R E E + + +E +
Sbjct: 2437 LQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ 2496
Query: 220 QLREQSRRPPSQNFARGERRSRLELELQSREQDLERAGLRQRERRGRRLQEHAERESQ 277
QLRE+ +R Q + +R +E R Q G+R+++ ++L++ ++ +
Sbjct: 2497 QLREEQQR-QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEE 2553
Score = 28.1 bits (61), Expect = 9.6
Identities = 31/128 (24%), Positives = 54/128 (42%), Gaps = 15/128 (11%)
Query: 164 LQRERPELLGSFEDVLIRASACLEEAARERDGLEQALRRRESEHEREVRALYEETEQLRE 223
LQRER + + A LE+ ++ Q LR + ++++ + E
Sbjct: 2471 LQRER---------FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2521
Query: 224 QSRR--PPSQNFARGERRSRLELELQSREQDLERAGLRQRERRGRRLQEHAER----ESQ 277
++RR ++ R ++ +LE Q R+Q+ A QR R +L E R S+
Sbjct: 2522 EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSE 2581
Query: 278 PATATGAA 285
TA+ A
Sbjct: 2582 EVTASQVA 2589
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 43.1 bits (100), Expect = 3e-04
Identities = 34/109 (31%), Positives = 53/109 (48%), Gaps = 14/109 (12%)
Query: 164 LQRERPELLGSFEDVLIRASACLEEAARERDGLEQ----------ALRRRESEHEREVRA 213
+++E+ +L F+D + +A EE R++ +EQ RRR+ E E VR
Sbjct: 2646 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2705
Query: 214 LYEETEQLREQSRRPPSQNFARGERRSRLELELQSREQDLERAGLRQRE 262
EE +QL EQ RR + A +R R +L+L ++ RA L E
Sbjct: 2706 KQEELQQL-EQQRRQQEELLAEENQRLREQLQLL---EEQHRAALAHSE 2750
Score = 41.6 bits (96), Expect = 8e-04
Identities = 31/99 (31%), Positives = 49/99 (49%), Gaps = 4/99 (4%)
Query: 181 RASACLEEAARERDGLEQALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRS 240
RA LEE + + E+ LR+ E E R+V+ E ++ E + +FA E+ +
Sbjct: 1670 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFA--EKTA 1727
Query: 241 RLELELQSREQDLERAGLRQRERRGRRLQEHAERESQPA 279
+LE LQ E+ + A LR+ R + Q AER + A
Sbjct: 1728 QLERSLQ--EEHVAVAQLREEAERRAQQQAEAERAREEA 1764
Score = 40.4 bits (93), Expect = 0.002
Identities = 53/190 (27%), Positives = 78/190 (41%), Gaps = 22/190 (11%)
Query: 104 ANPCRTPEE---TFESGGLDVQGTAGSLDEEEEEEERFHTVLEQLGVAPVLGKQRAVRTL 160
A+ R EE T E ++ AG E EE R + E+ L ++ A R
Sbjct: 1906 ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ- 1964
Query: 161 WARLQRERPELLGSFEDVLIRASACLEEAARERDGLEQALRRRESEHEREVRALYEETEQ 220
R + ER VL A + EA R + E AL+ +E+E+ER R +E Q
Sbjct: 1965 --RAEAER---------VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 2013
Query: 221 LREQSRRPPSQNFARGERRSRLELELQSREQDLER-AGLRQRERRGRRLQEH---AERES 276
R + ER ++L ++ + +LER GL + R RR E A + S
Sbjct: 2014 RRRLEEQAAQHKADIEERLAQLR---KASDSELERQKGLVEDTLRQRRQVEEEILALKAS 2070
Query: 277 QPATATGAAQ 286
A G A+
Sbjct: 2071 FEKAAAGKAE 2080
Score = 39.3 bits (90), Expect = 0.004
Identities = 72/315 (22%), Positives = 118/315 (37%), Gaps = 39/315 (12%)
Query: 9 ADEAQEEEGELEGGSAGPRAAILEQAEELFLLCDKEAKGFITKHDLQGLQSDLPLTPEQL 68
A+E ++ E +A R A LE+ E L ++ + + + Q L L E
Sbjct: 2123 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR--LRERAEQESARQLQLAQEAA 2180
Query: 69 EAVFESLDRAHTGFLTAREFCLG---------LGMFVGVASAQGANPCRTPEETFESGGL 119
+ ++ ++AH + +E L L G A A R E E +
Sbjct: 2181 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA-----ARRAAEEAEEARV 2235
Query: 120 DVQGTAGSLDEEEEEEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPELLGSFEDVL 179
+ A + EE ER E+ A Q A L ++E + + L
Sbjct: 2236 QAEREAAQSRRQVEEAERLKQSAEEQAQARAQA-QAAAEKLRKEAEQEAARRAQAEQAAL 2294
Query: 180 IRASACLEEAARERDGLEQALRRRESEHEREVRAL---YEETEQ----LREQSRRPPSQN 232
+ A E + + EQ LR++ ++ E+E+ L EET+ L E+ +R ++
Sbjct: 2295 RQKQAADAEMEKHKKFAEQTLRQK-AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2353
Query: 233 FARGERRSRLELELQSREQDLERAG--------------LRQRERRGRRLQEHAERESQP 278
+RS++E EL S +E LR ++ R LQE AE+ Q
Sbjct: 2354 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2413
Query: 279 ATATGAAQGAEYTAA 293
A A AA
Sbjct: 2414 AEEAARLSVAAQEAA 2428
Score = 37.4 bits (85), Expect = 0.016
Identities = 40/158 (25%), Positives = 67/158 (42%), Gaps = 7/158 (4%)
Query: 134 EEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPELLGSFEDVLIRASACLEEAARER 193
EEER E+ + ++ A R A L+ E L E+ +E+AR+
Sbjct: 2115 EEERRRREAEERVQKSLAAEEEAARQRKAALE-EVERLKAKVEEARRLRERAEQESARQL 2173
Query: 194 DGLEQALRRR----ESEHEREVRALYEETEQL--REQSRRPPSQNFARGERRSRLELELQ 247
++A ++R E H V+ +E +Q +EQS + A RR+ E E
Sbjct: 2174 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2233
Query: 248 SREQDLERAGLRQRERRGRRLQEHAERESQPATATGAA 285
+ + E A R++ RL++ AE ++Q AA
Sbjct: 2234 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2271
Score = 36.6 bits (83), Expect = 0.027
Identities = 39/127 (30%), Positives = 55/127 (43%), Gaps = 26/127 (20%)
Query: 162 ARLQRERPELLGSFEDVLIRASACLEEAARERDGLEQALRRRESEHEREVRALYEETEQL 221
A L+ E + + ED L EAAR+R + RRR ER ++L E E
Sbjct: 2079 AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 2138
Query: 222 REQSRRPPSQNFARGERRSRLELELQSREQDLERAGLRQRERRGRRLQEHAERES--QPA 279
R +R++ LE ++ER L+ + RRL+E AE+ES Q
Sbjct: 2139 R--------------QRKAALE--------EVER--LKAKVEEARRLRERAEQESARQLQ 2174
Query: 280 TATGAAQ 286
A AAQ
Sbjct: 2175 LAQEAAQ 2181
Score = 35.0 bits (79), Expect = 0.079
Identities = 43/145 (29%), Positives = 66/145 (45%), Gaps = 15/145 (10%)
Query: 153 KQRAVRTLWA-RLQRERPE--LLGSFEDVLIRASACLEEAARERDGLEQALRRRESEHER 209
KQRA++ L RLQ E E L + + + LE A R + Q+ R +E
Sbjct: 1668 KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA 1727
Query: 210 EV-RALYEE---TEQLREQSRRPPSQNFARGERRSRLELELQSREQDLERAGLRQRERRG 265
++ R+L EE QLRE++ R R ++++ E + E++LER L+ E
Sbjct: 1728 QLERSLQEEHVAVAQLREEAER-------RAQQQAEAERAREEAERELERWQLKANEALR 1780
Query: 266 RRLQ-EHAERESQPATATGAAQGAE 289
RLQ E ++ A A Q E
Sbjct: 1781 LRLQAEEVAQQKSLAQAEAEKQKEE 1805
Score = 35.0 bits (79), Expect = 0.079
Identities = 35/135 (25%), Positives = 55/135 (40%), Gaps = 8/135 (5%)
Query: 153 KQRAVRTL--WARLQRERPELLGSFEDVLIRASACLEEAARERDGLEQALRRRESEHERE 210
++ A R L W E L E+V + S EA ++++ E+ RRR E+
Sbjct: 1761 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1820
Query: 211 VR---ALYEETEQLREQSRRPPSQNFARGERRSRLELELQSREQD---LERAGLRQRERR 264
VR +E E+ R+ + Q A + RL E + EQ LE R +
Sbjct: 1821 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1880
Query: 265 GRRLQEHAERESQPA 279
Q+ E E++ A
Sbjct: 1881 AAATQKRQELEAELA 1895
Score = 31.6 bits (70), Expect = 0.87
Identities = 26/118 (22%), Positives = 57/118 (48%), Gaps = 5/118 (4%)
Query: 164 LQRERPELLGSFEDVLIRASACLEEA-ARERDGLEQALRRRESEHEREVRALYEET---E 219
LQ + E+ ++ L++ + L+++ E+D L Q R E E + + +E +
Sbjct: 2606 LQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ 2665
Query: 220 QLREQSRRPPSQNFARGERRSRLELELQSREQDLERAGLRQRERRGRRLQEHAERESQ 277
QLRE+ +R Q + +R +E R Q G+R+++ ++L++ ++ +
Sbjct: 2666 QLREEQQR-QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEE 2722
Score = 28.1 bits (61), Expect = 9.6
Identities = 31/128 (24%), Positives = 54/128 (42%), Gaps = 15/128 (11%)
Query: 164 LQRERPELLGSFEDVLIRASACLEEAARERDGLEQALRRRESEHEREVRALYEETEQLRE 223
LQRER + + A LE+ ++ Q LR + ++++ + E
Sbjct: 2640 LQRER---------FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2690
Query: 224 QSRR--PPSQNFARGERRSRLELELQSREQDLERAGLRQRERRGRRLQEHAER----ESQ 277
++RR ++ R ++ +LE Q R+Q+ A QR R +L E R S+
Sbjct: 2691 EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSE 2750
Query: 278 PATATGAA 285
TA+ A
Sbjct: 2751 EVTASQVA 2758
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 43.1 bits (100), Expect = 3e-04
Identities = 34/109 (31%), Positives = 53/109 (48%), Gaps = 14/109 (12%)
Query: 164 LQRERPELLGSFEDVLIRASACLEEAARERDGLEQ----------ALRRRESEHEREVRA 213
+++E+ +L F+D + +A EE R++ +EQ RRR+ E E VR
Sbjct: 2487 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2546
Query: 214 LYEETEQLREQSRRPPSQNFARGERRSRLELELQSREQDLERAGLRQRE 262
EE +QL EQ RR + A +R R +L+L ++ RA L E
Sbjct: 2547 KQEELQQL-EQQRRQQEELLAEENQRLREQLQLL---EEQHRAALAHSE 2591
Score = 41.6 bits (96), Expect = 8e-04
Identities = 31/99 (31%), Positives = 49/99 (49%), Gaps = 4/99 (4%)
Query: 181 RASACLEEAARERDGLEQALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRS 240
RA LEE + + E+ LR+ E E R+V+ E ++ E + +FA E+ +
Sbjct: 1511 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFA--EKTA 1568
Query: 241 RLELELQSREQDLERAGLRQRERRGRRLQEHAERESQPA 279
+LE LQ E+ + A LR+ R + Q AER + A
Sbjct: 1569 QLERSLQ--EEHVAVAQLREEAERRAQQQAEAERAREEA 1605
Score = 40.4 bits (93), Expect = 0.002
Identities = 53/190 (27%), Positives = 78/190 (41%), Gaps = 22/190 (11%)
Query: 104 ANPCRTPEE---TFESGGLDVQGTAGSLDEEEEEEERFHTVLEQLGVAPVLGKQRAVRTL 160
A+ R EE T E ++ AG E EE R + E+ L ++ A R
Sbjct: 1747 ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ- 1805
Query: 161 WARLQRERPELLGSFEDVLIRASACLEEAARERDGLEQALRRRESEHEREVRALYEETEQ 220
R + ER VL A + EA R + E AL+ +E+E+ER R +E Q
Sbjct: 1806 --RAEAER---------VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1854
Query: 221 LREQSRRPPSQNFARGERRSRLELELQSREQDLER-AGLRQRERRGRRLQEH---AERES 276
R + ER ++L ++ + +LER GL + R RR E A + S
Sbjct: 1855 RRRLEEQAAQHKADIEERLAQLR---KASDSELERQKGLVEDTLRQRRQVEEEILALKAS 1911
Query: 277 QPATATGAAQ 286
A G A+
Sbjct: 1912 FEKAAAGKAE 1921
Score = 39.3 bits (90), Expect = 0.004
Identities = 72/315 (22%), Positives = 118/315 (37%), Gaps = 39/315 (12%)
Query: 9 ADEAQEEEGELEGGSAGPRAAILEQAEELFLLCDKEAKGFITKHDLQGLQSDLPLTPEQL 68
A+E ++ E +A R A LE+ E L ++ + + + Q L L E
Sbjct: 1964 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR--LRERAEQESARQLQLAQEAA 2021
Query: 69 EAVFESLDRAHTGFLTAREFCLG---------LGMFVGVASAQGANPCRTPEETFESGGL 119
+ ++ ++AH + +E L L G A A R E E +
Sbjct: 2022 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA-----ARRAAEEAEEARV 2076
Query: 120 DVQGTAGSLDEEEEEEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPELLGSFEDVL 179
+ A + EE ER E+ A Q A L ++E + + L
Sbjct: 2077 QAEREAAQSRRQVEEAERLKQSAEEQAQARAQA-QAAAEKLRKEAEQEAARRAQAEQAAL 2135
Query: 180 IRASACLEEAARERDGLEQALRRRESEHEREVRAL---YEETEQ----LREQSRRPPSQN 232
+ A E + + EQ LR++ ++ E+E+ L EET+ L E+ +R ++
Sbjct: 2136 RQKQAADAEMEKHKKFAEQTLRQK-AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2194
Query: 233 FARGERRSRLELELQSREQDLERAG--------------LRQRERRGRRLQEHAERESQP 278
+RS++E EL S +E LR ++ R LQE AE+ Q
Sbjct: 2195 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2254
Query: 279 ATATGAAQGAEYTAA 293
A A AA
Sbjct: 2255 AEEAARLSVAAQEAA 2269
Score = 37.4 bits (85), Expect = 0.016
Identities = 40/158 (25%), Positives = 67/158 (42%), Gaps = 7/158 (4%)
Query: 134 EEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPELLGSFEDVLIRASACLEEAARER 193
EEER E+ + ++ A R A L+ E L E+ +E+AR+
Sbjct: 1956 EEERRRREAEERVQKSLAAEEEAARQRKAALE-EVERLKAKVEEARRLRERAEQESARQL 2014
Query: 194 DGLEQALRRR----ESEHEREVRALYEETEQL--REQSRRPPSQNFARGERRSRLELELQ 247
++A ++R E H V+ +E +Q +EQS + A RR+ E E
Sbjct: 2015 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2074
Query: 248 SREQDLERAGLRQRERRGRRLQEHAERESQPATATGAA 285
+ + E A R++ RL++ AE ++Q AA
Sbjct: 2075 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2112
Score = 36.6 bits (83), Expect = 0.027
Identities = 39/127 (30%), Positives = 55/127 (43%), Gaps = 26/127 (20%)
Query: 162 ARLQRERPELLGSFEDVLIRASACLEEAARERDGLEQALRRRESEHEREVRALYEETEQL 221
A L+ E + + ED L EAAR+R + RRR ER ++L E E
Sbjct: 1920 AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 1979
Query: 222 REQSRRPPSQNFARGERRSRLELELQSREQDLERAGLRQRERRGRRLQEHAERES--QPA 279
R +R++ LE ++ER L+ + RRL+E AE+ES Q
Sbjct: 1980 R--------------QRKAALE--------EVER--LKAKVEEARRLRERAEQESARQLQ 2015
Query: 280 TATGAAQ 286
A AAQ
Sbjct: 2016 LAQEAAQ 2022
Score = 35.0 bits (79), Expect = 0.079
Identities = 43/145 (29%), Positives = 66/145 (45%), Gaps = 15/145 (10%)
Query: 153 KQRAVRTLWA-RLQRERPE--LLGSFEDVLIRASACLEEAARERDGLEQALRRRESEHER 209
KQRA++ L RLQ E E L + + + LE A R + Q+ R +E
Sbjct: 1509 KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA 1568
Query: 210 EV-RALYEE---TEQLREQSRRPPSQNFARGERRSRLELELQSREQDLERAGLRQRERRG 265
++ R+L EE QLRE++ R R ++++ E + E++LER L+ E
Sbjct: 1569 QLERSLQEEHVAVAQLREEAER-------RAQQQAEAERAREEAERELERWQLKANEALR 1621
Query: 266 RRLQ-EHAERESQPATATGAAQGAE 289
RLQ E ++ A A Q E
Sbjct: 1622 LRLQAEEVAQQKSLAQAEAEKQKEE 1646
Score = 35.0 bits (79), Expect = 0.079
Identities = 35/135 (25%), Positives = 55/135 (40%), Gaps = 8/135 (5%)
Query: 153 KQRAVRTL--WARLQRERPELLGSFEDVLIRASACLEEAARERDGLEQALRRRESEHERE 210
++ A R L W E L E+V + S EA ++++ E+ RRR E+
Sbjct: 1602 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1661
Query: 211 VR---ALYEETEQLREQSRRPPSQNFARGERRSRLELELQSREQD---LERAGLRQRERR 264
VR +E E+ R+ + Q A + RL E + EQ LE R +
Sbjct: 1662 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1721
Query: 265 GRRLQEHAERESQPA 279
Q+ E E++ A
Sbjct: 1722 AAATQKRQELEAELA 1736
Score = 31.6 bits (70), Expect = 0.87
Identities = 26/118 (22%), Positives = 57/118 (48%), Gaps = 5/118 (4%)
Query: 164 LQRERPELLGSFEDVLIRASACLEEA-ARERDGLEQALRRRESEHEREVRALYEET---E 219
LQ + E+ ++ L++ + L+++ E+D L Q R E E + + +E +
Sbjct: 2447 LQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ 2506
Query: 220 QLREQSRRPPSQNFARGERRSRLELELQSREQDLERAGLRQRERRGRRLQEHAERESQ 277
QLRE+ +R Q + +R +E R Q G+R+++ ++L++ ++ +
Sbjct: 2507 QLREEQQR-QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEE 2563
Score = 28.1 bits (61), Expect = 9.6
Identities = 31/128 (24%), Positives = 54/128 (42%), Gaps = 15/128 (11%)
Query: 164 LQRERPELLGSFEDVLIRASACLEEAARERDGLEQALRRRESEHEREVRALYEETEQLRE 223
LQRER + + A LE+ ++ Q LR + ++++ + E
Sbjct: 2481 LQRER---------FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2531
Query: 224 QSRR--PPSQNFARGERRSRLELELQSREQDLERAGLRQRERRGRRLQEHAER----ESQ 277
++RR ++ R ++ +LE Q R+Q+ A QR R +L E R S+
Sbjct: 2532 EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSE 2591
Query: 278 PATATGAA 285
TA+ A
Sbjct: 2592 EVTASQVA 2599
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 43.1 bits (100), Expect = 3e-04
Identities = 34/109 (31%), Positives = 53/109 (48%), Gaps = 14/109 (12%)
Query: 164 LQRERPELLGSFEDVLIRASACLEEAARERDGLEQ----------ALRRRESEHEREVRA 213
+++E+ +L F+D + +A EE R++ +EQ RRR+ E E VR
Sbjct: 2495 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2554
Query: 214 LYEETEQLREQSRRPPSQNFARGERRSRLELELQSREQDLERAGLRQRE 262
EE +QL EQ RR + A +R R +L+L ++ RA L E
Sbjct: 2555 KQEELQQL-EQQRRQQEELLAEENQRLREQLQLL---EEQHRAALAHSE 2599
Score = 41.6 bits (96), Expect = 8e-04
Identities = 31/99 (31%), Positives = 49/99 (49%), Gaps = 4/99 (4%)
Query: 181 RASACLEEAARERDGLEQALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRS 240
RA LEE + + E+ LR+ E E R+V+ E ++ E + +FA E+ +
Sbjct: 1519 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFA--EKTA 1576
Query: 241 RLELELQSREQDLERAGLRQRERRGRRLQEHAERESQPA 279
+LE LQ E+ + A LR+ R + Q AER + A
Sbjct: 1577 QLERSLQ--EEHVAVAQLREEAERRAQQQAEAERAREEA 1613
Score = 40.4 bits (93), Expect = 0.002
Identities = 53/190 (27%), Positives = 78/190 (41%), Gaps = 22/190 (11%)
Query: 104 ANPCRTPEE---TFESGGLDVQGTAGSLDEEEEEEERFHTVLEQLGVAPVLGKQRAVRTL 160
A+ R EE T E ++ AG E EE R + E+ L ++ A R
Sbjct: 1755 ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ- 1813
Query: 161 WARLQRERPELLGSFEDVLIRASACLEEAARERDGLEQALRRRESEHEREVRALYEETEQ 220
R + ER VL A + EA R + E AL+ +E+E+ER R +E Q
Sbjct: 1814 --RAEAER---------VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1862
Query: 221 LREQSRRPPSQNFARGERRSRLELELQSREQDLER-AGLRQRERRGRRLQEH---AERES 276
R + ER ++L ++ + +LER GL + R RR E A + S
Sbjct: 1863 RRRLEEQAAQHKADIEERLAQLR---KASDSELERQKGLVEDTLRQRRQVEEEILALKAS 1919
Query: 277 QPATATGAAQ 286
A G A+
Sbjct: 1920 FEKAAAGKAE 1929
Score = 39.3 bits (90), Expect = 0.004
Identities = 72/315 (22%), Positives = 118/315 (37%), Gaps = 39/315 (12%)
Query: 9 ADEAQEEEGELEGGSAGPRAAILEQAEELFLLCDKEAKGFITKHDLQGLQSDLPLTPEQL 68
A+E ++ E +A R A LE+ E L ++ + + + Q L L E
Sbjct: 1972 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR--LRERAEQESARQLQLAQEAA 2029
Query: 69 EAVFESLDRAHTGFLTAREFCLG---------LGMFVGVASAQGANPCRTPEETFESGGL 119
+ ++ ++AH + +E L L G A A R E E +
Sbjct: 2030 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA-----ARRAAEEAEEARV 2084
Query: 120 DVQGTAGSLDEEEEEEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPELLGSFEDVL 179
+ A + EE ER E+ A Q A L ++E + + L
Sbjct: 2085 QAEREAAQSRRQVEEAERLKQSAEEQAQARAQA-QAAAEKLRKEAEQEAARRAQAEQAAL 2143
Query: 180 IRASACLEEAARERDGLEQALRRRESEHEREVRAL---YEETEQ----LREQSRRPPSQN 232
+ A E + + EQ LR++ ++ E+E+ L EET+ L E+ +R ++
Sbjct: 2144 RQKQAADAEMEKHKKFAEQTLRQK-AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2202
Query: 233 FARGERRSRLELELQSREQDLERAG--------------LRQRERRGRRLQEHAERESQP 278
+RS++E EL S +E LR ++ R LQE AE+ Q
Sbjct: 2203 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2262
Query: 279 ATATGAAQGAEYTAA 293
A A AA
Sbjct: 2263 AEEAARLSVAAQEAA 2277
Score = 37.4 bits (85), Expect = 0.016
Identities = 40/158 (25%), Positives = 67/158 (42%), Gaps = 7/158 (4%)
Query: 134 EEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPELLGSFEDVLIRASACLEEAARER 193
EEER E+ + ++ A R A L+ E L E+ +E+AR+
Sbjct: 1964 EEERRRREAEERVQKSLAAEEEAARQRKAALE-EVERLKAKVEEARRLRERAEQESARQL 2022
Query: 194 DGLEQALRRR----ESEHEREVRALYEETEQL--REQSRRPPSQNFARGERRSRLELELQ 247
++A ++R E H V+ +E +Q +EQS + A RR+ E E
Sbjct: 2023 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2082
Query: 248 SREQDLERAGLRQRERRGRRLQEHAERESQPATATGAA 285
+ + E A R++ RL++ AE ++Q AA
Sbjct: 2083 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2120
Score = 36.6 bits (83), Expect = 0.027
Identities = 39/127 (30%), Positives = 55/127 (43%), Gaps = 26/127 (20%)
Query: 162 ARLQRERPELLGSFEDVLIRASACLEEAARERDGLEQALRRRESEHEREVRALYEETEQL 221
A L+ E + + ED L EAAR+R + RRR ER ++L E E
Sbjct: 1928 AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 1987
Query: 222 REQSRRPPSQNFARGERRSRLELELQSREQDLERAGLRQRERRGRRLQEHAERES--QPA 279
R +R++ LE ++ER L+ + RRL+E AE+ES Q
Sbjct: 1988 R--------------QRKAALE--------EVER--LKAKVEEARRLRERAEQESARQLQ 2023
Query: 280 TATGAAQ 286
A AAQ
Sbjct: 2024 LAQEAAQ 2030
Score = 35.0 bits (79), Expect = 0.079
Identities = 43/145 (29%), Positives = 66/145 (45%), Gaps = 15/145 (10%)
Query: 153 KQRAVRTLWA-RLQRERPE--LLGSFEDVLIRASACLEEAARERDGLEQALRRRESEHER 209
KQRA++ L RLQ E E L + + + LE A R + Q+ R +E
Sbjct: 1517 KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA 1576
Query: 210 EV-RALYEE---TEQLREQSRRPPSQNFARGERRSRLELELQSREQDLERAGLRQRERRG 265
++ R+L EE QLRE++ R R ++++ E + E++LER L+ E
Sbjct: 1577 QLERSLQEEHVAVAQLREEAER-------RAQQQAEAERAREEAERELERWQLKANEALR 1629
Query: 266 RRLQ-EHAERESQPATATGAAQGAE 289
RLQ E ++ A A Q E
Sbjct: 1630 LRLQAEEVAQQKSLAQAEAEKQKEE 1654
Score = 35.0 bits (79), Expect = 0.079
Identities = 35/135 (25%), Positives = 55/135 (40%), Gaps = 8/135 (5%)
Query: 153 KQRAVRTL--WARLQRERPELLGSFEDVLIRASACLEEAARERDGLEQALRRRESEHERE 210
++ A R L W E L E+V + S EA ++++ E+ RRR E+
Sbjct: 1610 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1669
Query: 211 VR---ALYEETEQLREQSRRPPSQNFARGERRSRLELELQSREQD---LERAGLRQRERR 264
VR +E E+ R+ + Q A + RL E + EQ LE R +
Sbjct: 1670 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1729
Query: 265 GRRLQEHAERESQPA 279
Q+ E E++ A
Sbjct: 1730 AAATQKRQELEAELA 1744
Score = 31.6 bits (70), Expect = 0.87
Identities = 26/118 (22%), Positives = 57/118 (48%), Gaps = 5/118 (4%)
Query: 164 LQRERPELLGSFEDVLIRASACLEEA-ARERDGLEQALRRRESEHEREVRALYEET---E 219
LQ + E+ ++ L++ + L+++ E+D L Q R E E + + +E +
Sbjct: 2455 LQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ 2514
Query: 220 QLREQSRRPPSQNFARGERRSRLELELQSREQDLERAGLRQRERRGRRLQEHAERESQ 277
QLRE+ +R Q + +R +E R Q G+R+++ ++L++ ++ +
Sbjct: 2515 QLREEQQR-QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEE 2571
Score = 28.1 bits (61), Expect = 9.6
Identities = 31/128 (24%), Positives = 54/128 (42%), Gaps = 15/128 (11%)
Query: 164 LQRERPELLGSFEDVLIRASACLEEAARERDGLEQALRRRESEHEREVRALYEETEQLRE 223
LQRER + + A LE+ ++ Q LR + ++++ + E
Sbjct: 2489 LQRER---------FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2539
Query: 224 QSRR--PPSQNFARGERRSRLELELQSREQDLERAGLRQRERRGRRLQEHAER----ESQ 277
++RR ++ R ++ +LE Q R+Q+ A QR R +L E R S+
Sbjct: 2540 EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSE 2599
Query: 278 PATATGAA 285
TA+ A
Sbjct: 2600 EVTASQVA 2607
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 43.1 bits (100), Expect = 3e-04
Identities = 34/109 (31%), Positives = 53/109 (48%), Gaps = 14/109 (12%)
Query: 164 LQRERPELLGSFEDVLIRASACLEEAARERDGLEQ----------ALRRRESEHEREVRA 213
+++E+ +L F+D + +A EE R++ +EQ RRR+ E E VR
Sbjct: 2536 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2595
Query: 214 LYEETEQLREQSRRPPSQNFARGERRSRLELELQSREQDLERAGLRQRE 262
EE +QL EQ RR + A +R R +L+L ++ RA L E
Sbjct: 2596 KQEELQQL-EQQRRQQEELLAEENQRLREQLQLL---EEQHRAALAHSE 2640
Score = 41.6 bits (96), Expect = 8e-04
Identities = 31/99 (31%), Positives = 49/99 (49%), Gaps = 4/99 (4%)
Query: 181 RASACLEEAARERDGLEQALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRS 240
RA LEE + + E+ LR+ E E R+V+ E ++ E + +FA E+ +
Sbjct: 1560 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFA--EKTA 1617
Query: 241 RLELELQSREQDLERAGLRQRERRGRRLQEHAERESQPA 279
+LE LQ E+ + A LR+ R + Q AER + A
Sbjct: 1618 QLERSLQ--EEHVAVAQLREEAERRAQQQAEAERAREEA 1654
Score = 40.4 bits (93), Expect = 0.002
Identities = 53/190 (27%), Positives = 78/190 (41%), Gaps = 22/190 (11%)
Query: 104 ANPCRTPEE---TFESGGLDVQGTAGSLDEEEEEEERFHTVLEQLGVAPVLGKQRAVRTL 160
A+ R EE T E ++ AG E EE R + E+ L ++ A R
Sbjct: 1796 ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ- 1854
Query: 161 WARLQRERPELLGSFEDVLIRASACLEEAARERDGLEQALRRRESEHEREVRALYEETEQ 220
R + ER VL A + EA R + E AL+ +E+E+ER R +E Q
Sbjct: 1855 --RAEAER---------VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1903
Query: 221 LREQSRRPPSQNFARGERRSRLELELQSREQDLER-AGLRQRERRGRRLQEH---AERES 276
R + ER ++L ++ + +LER GL + R RR E A + S
Sbjct: 1904 RRRLEEQAAQHKADIEERLAQLR---KASDSELERQKGLVEDTLRQRRQVEEEILALKAS 1960
Query: 277 QPATATGAAQ 286
A G A+
Sbjct: 1961 FEKAAAGKAE 1970
Score = 39.3 bits (90), Expect = 0.004
Identities = 72/315 (22%), Positives = 118/315 (37%), Gaps = 39/315 (12%)
Query: 9 ADEAQEEEGELEGGSAGPRAAILEQAEELFLLCDKEAKGFITKHDLQGLQSDLPLTPEQL 68
A+E ++ E +A R A LE+ E L ++ + + + Q L L E
Sbjct: 2013 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR--LRERAEQESARQLQLAQEAA 2070
Query: 69 EAVFESLDRAHTGFLTAREFCLG---------LGMFVGVASAQGANPCRTPEETFESGGL 119
+ ++ ++AH + +E L L G A A R E E +
Sbjct: 2071 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA-----ARRAAEEAEEARV 2125
Query: 120 DVQGTAGSLDEEEEEEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPELLGSFEDVL 179
+ A + EE ER E+ A Q A L ++E + + L
Sbjct: 2126 QAEREAAQSRRQVEEAERLKQSAEEQAQARAQA-QAAAEKLRKEAEQEAARRAQAEQAAL 2184
Query: 180 IRASACLEEAARERDGLEQALRRRESEHEREVRAL---YEETEQ----LREQSRRPPSQN 232
+ A E + + EQ LR++ ++ E+E+ L EET+ L E+ +R ++
Sbjct: 2185 RQKQAADAEMEKHKKFAEQTLRQK-AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2243
Query: 233 FARGERRSRLELELQSREQDLERAG--------------LRQRERRGRRLQEHAERESQP 278
+RS++E EL S +E LR ++ R LQE AE+ Q
Sbjct: 2244 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2303
Query: 279 ATATGAAQGAEYTAA 293
A A AA
Sbjct: 2304 AEEAARLSVAAQEAA 2318
Score = 37.4 bits (85), Expect = 0.016
Identities = 40/158 (25%), Positives = 67/158 (42%), Gaps = 7/158 (4%)
Query: 134 EEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPELLGSFEDVLIRASACLEEAARER 193
EEER E+ + ++ A R A L+ E L E+ +E+AR+
Sbjct: 2005 EEERRRREAEERVQKSLAAEEEAARQRKAALE-EVERLKAKVEEARRLRERAEQESARQL 2063
Query: 194 DGLEQALRRR----ESEHEREVRALYEETEQL--REQSRRPPSQNFARGERRSRLELELQ 247
++A ++R E H V+ +E +Q +EQS + A RR+ E E
Sbjct: 2064 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2123
Query: 248 SREQDLERAGLRQRERRGRRLQEHAERESQPATATGAA 285
+ + E A R++ RL++ AE ++Q AA
Sbjct: 2124 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2161
Score = 36.6 bits (83), Expect = 0.027
Identities = 39/127 (30%), Positives = 55/127 (43%), Gaps = 26/127 (20%)
Query: 162 ARLQRERPELLGSFEDVLIRASACLEEAARERDGLEQALRRRESEHEREVRALYEETEQL 221
A L+ E + + ED L EAAR+R + RRR ER ++L E E
Sbjct: 1969 AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 2028
Query: 222 REQSRRPPSQNFARGERRSRLELELQSREQDLERAGLRQRERRGRRLQEHAERES--QPA 279
R +R++ LE ++ER L+ + RRL+E AE+ES Q
Sbjct: 2029 R--------------QRKAALE--------EVER--LKAKVEEARRLRERAEQESARQLQ 2064
Query: 280 TATGAAQ 286
A AAQ
Sbjct: 2065 LAQEAAQ 2071
Score = 35.0 bits (79), Expect = 0.079
Identities = 43/145 (29%), Positives = 66/145 (45%), Gaps = 15/145 (10%)
Query: 153 KQRAVRTLWA-RLQRERPE--LLGSFEDVLIRASACLEEAARERDGLEQALRRRESEHER 209
KQRA++ L RLQ E E L + + + LE A R + Q+ R +E
Sbjct: 1558 KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA 1617
Query: 210 EV-RALYEE---TEQLREQSRRPPSQNFARGERRSRLELELQSREQDLERAGLRQRERRG 265
++ R+L EE QLRE++ R R ++++ E + E++LER L+ E
Sbjct: 1618 QLERSLQEEHVAVAQLREEAER-------RAQQQAEAERAREEAERELERWQLKANEALR 1670
Query: 266 RRLQ-EHAERESQPATATGAAQGAE 289
RLQ E ++ A A Q E
Sbjct: 1671 LRLQAEEVAQQKSLAQAEAEKQKEE 1695
Score = 35.0 bits (79), Expect = 0.079
Identities = 35/135 (25%), Positives = 55/135 (40%), Gaps = 8/135 (5%)
Query: 153 KQRAVRTL--WARLQRERPELLGSFEDVLIRASACLEEAARERDGLEQALRRRESEHERE 210
++ A R L W E L E+V + S EA ++++ E+ RRR E+
Sbjct: 1651 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1710
Query: 211 VR---ALYEETEQLREQSRRPPSQNFARGERRSRLELELQSREQD---LERAGLRQRERR 264
VR +E E+ R+ + Q A + RL E + EQ LE R +
Sbjct: 1711 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1770
Query: 265 GRRLQEHAERESQPA 279
Q+ E E++ A
Sbjct: 1771 AAATQKRQELEAELA 1785
Score = 31.6 bits (70), Expect = 0.87
Identities = 26/118 (22%), Positives = 57/118 (48%), Gaps = 5/118 (4%)
Query: 164 LQRERPELLGSFEDVLIRASACLEEA-ARERDGLEQALRRRESEHEREVRALYEET---E 219
LQ + E+ ++ L++ + L+++ E+D L Q R E E + + +E +
Sbjct: 2496 LQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ 2555
Query: 220 QLREQSRRPPSQNFARGERRSRLELELQSREQDLERAGLRQRERRGRRLQEHAERESQ 277
QLRE+ +R Q + +R +E R Q G+R+++ ++L++ ++ +
Sbjct: 2556 QLREEQQR-QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEE 2612
Score = 28.1 bits (61), Expect = 9.6
Identities = 31/128 (24%), Positives = 54/128 (42%), Gaps = 15/128 (11%)
Query: 164 LQRERPELLGSFEDVLIRASACLEEAARERDGLEQALRRRESEHEREVRALYEETEQLRE 223
LQRER + + A LE+ ++ Q LR + ++++ + E
Sbjct: 2530 LQRER---------FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2580
Query: 224 QSRR--PPSQNFARGERRSRLELELQSREQDLERAGLRQRERRGRRLQEHAER----ESQ 277
++RR ++ R ++ +LE Q R+Q+ A QR R +L E R S+
Sbjct: 2581 EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSE 2640
Query: 278 PATATGAA 285
TA+ A
Sbjct: 2641 EVTASQVA 2648
>gi|78042577 MAP7 domain containing 1 [Homo sapiens]
Length = 841
Score = 43.1 bits (100), Expect = 3e-04
Identities = 43/135 (31%), Positives = 65/135 (48%), Gaps = 13/135 (9%)
Query: 162 ARLQRERPEL---LGSFEDVLIRASACLEEAARERDGLEQALRRRESEHEREVRALYEET 218
AR QRER E L + D +R EA R E RRRE + RE +A E+
Sbjct: 610 AREQREREEQERRLQAERDKRMREEQLAREA-EARAEREAEARRREEQEARE-KAQAEQE 667
Query: 219 EQLREQSRRPPSQNFARGE-RRSRLELELQSREQDLERAGLR-------QRERRGRRLQE 270
EQ R Q ++ ++ +R E R RLE E ++Q+ ER R +R R+ +
Sbjct: 668 EQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEEIMKRTRKSEVSET 727
Query: 271 HAERESQPATATGAA 285
+++S+ A A G++
Sbjct: 728 KQKQDSKEANANGSS 742
Score = 37.4 bits (85), Expect = 0.016
Identities = 24/76 (31%), Positives = 36/76 (47%), Gaps = 3/76 (3%)
Query: 205 SEHEREVRALYEETEQLREQSRRPPSQNFARGERRSRLELELQSREQDL---ERAGLRQR 261
++ E R L E+ Q REQ R + + ER R+ E +RE + A R+R
Sbjct: 594 TDREEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRR 653
Query: 262 ERRGRRLQEHAERESQ 277
E + R + AE+E Q
Sbjct: 654 EEQEAREKAQAEQEEQ 669
Score = 35.4 bits (80), Expect = 0.060
Identities = 36/135 (26%), Positives = 58/135 (42%), Gaps = 20/135 (14%)
Query: 130 EEEEEEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPELLGSFEDVLIRASACLEEA 189
E EE+E R ++ + +++ R AR +RE A E+
Sbjct: 615 EREEQERRLQAERDKR-----MREEQLAREAEARAERE------------AEARRREEQE 657
Query: 190 ARERDGLEQALRRR--ESEHEREVRALYEETEQLREQSRRPPSQNFARGERRSRLELELQ 247
ARE+ EQ + R + + E E R+ E Q E+ + Q R ERR RLE E+
Sbjct: 658 AREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLE-EIM 716
Query: 248 SREQDLERAGLRQRE 262
R + E + +Q++
Sbjct: 717 KRTRKSEVSETKQKQ 731
Score = 33.1 bits (74), Expect = 0.30
Identities = 25/94 (26%), Positives = 43/94 (45%), Gaps = 5/94 (5%)
Query: 187 EEAARERDGLEQALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRSRLELEL 246
EEA R + R + E+E R E +++RE+ ++ A E +R E
Sbjct: 597 EEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRREEQ 656
Query: 247 QSR-----EQDLERAGLRQRERRGRRLQEHAERE 275
++R EQ+ + +Q+E R +E AER+
Sbjct: 657 EAREKAQAEQEEQERLQKQKEEAEARSREEAERQ 690
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 42.7 bits (99), Expect = 4e-04
Identities = 39/141 (27%), Positives = 66/141 (46%), Gaps = 9/141 (6%)
Query: 153 KQRAVRTLWARLQRERPE---LLGSFEDVLIRASACLEEAARERDGLEQALRRRESEHER 209
K+R V L +L + L S ED+ ++A +EAA++ + ++ L R+ S+ E+
Sbjct: 908 KERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEK 967
Query: 210 EVRALYEETEQLREQSRRPPSQNFARGER-RSRLELELQSREQDLERAGLRQRERRGRRL 268
++ + + ++L+ + R S+ + E L+ L E L+ A RE L
Sbjct: 968 KMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGA----REENSGLL 1023
Query: 269 QEHAERESQPATATGAAQGAE 289
QE E Q A AAQ AE
Sbjct: 1024 QELEELRKQ-ADKAKAAQTAE 1043
Score = 40.4 bits (93), Expect = 0.002
Identities = 43/186 (23%), Positives = 77/186 (41%), Gaps = 29/186 (15%)
Query: 108 RTPEETFESGGLDVQGTAGSLDEEEEEEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRE 167
R EE+ G L+V + E+ R + + L + + + V L RL+
Sbjct: 444 RVEEESITKGDLEVATVS--------EKSRIMELEKDLAL-----RVQEVAELRRRLESN 490
Query: 168 RP--------ELLGSFEDVLIRASACLEEAARERDGLEQALRRRESEHEREVRALYEETE 219
+P LL + + + RE L++ RE H++E++ALY TE
Sbjct: 491 KPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATE 550
Query: 220 QLREQSRRPPSQ-NFARGER-------RSRLELELQSREQDLERAGLRQRERRGRRLQEH 271
+L +++ S+ A E +S+LE + S +Q +E + + G E
Sbjct: 551 KLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEF 610
Query: 272 AERESQ 277
AE ++Q
Sbjct: 611 AELKTQ 616
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.131 0.362
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,049,272
Number of Sequences: 37866
Number of extensions: 576989
Number of successful extensions: 6192
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 231
Number of HSP's successfully gapped in prelim test: 386
Number of HSP's that attempted gapping in prelim test: 3504
Number of HSP's gapped (non-prelim): 2089
length of query: 294
length of database: 18,247,518
effective HSP length: 101
effective length of query: 193
effective length of database: 14,423,052
effective search space: 2783649036
effective search space used: 2783649036
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.