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Search of human proteins with 109826351
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|109826351 melanophilin isoform 2 [Homo sapiens]
(572 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|109826351 melanophilin isoform 2 [Homo sapiens] 1143 0.0
gi|13129108 melanophilin isoform 1 [Homo sapiens] 1128 0.0
gi|59853352 myosin VIIA and Rab interacting protein [Homo sapiens] 171 1e-42
gi|193804862 synaptotagmin-like 4 [Homo sapiens] 74 4e-13
gi|193804860 synaptotagmin-like 4 [Homo sapiens] 74 4e-13
gi|110227631 synaptotagmin-like 3 [Homo sapiens] 68 2e-11
gi|254039650 synaptotagmin-like 5 isoform 1 [Homo sapiens] 66 8e-11
gi|254039648 synaptotagmin-like 5 isoform 2 [Homo sapiens] 66 8e-11
gi|20270305 synaptotagmin-like 5 isoform 1 [Homo sapiens] 66 8e-11
gi|194272142 myosin IXB isoform 2 [Homo sapiens] 58 3e-08
gi|33356170 myosin IXB isoform 1 [Homo sapiens] 58 3e-08
gi|219804203 rabphilin 3A homolog isoform 1 [Homo sapiens] 47 5e-05
gi|45267837 rabphilin 3A homolog isoform 2 [Homo sapiens] 47 5e-05
gi|60097902 filaggrin [Homo sapiens] 45 2e-04
gi|15011902 synaptotagmin-like 2 isoform a [Homo sapiens] 44 3e-04
gi|244790020 synaptotagmin-like 2 isoform i [Homo sapiens] 44 3e-04
gi|244790013 synaptotagmin-like 2 isoform g [Homo sapiens] 44 3e-04
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e... 44 5e-04
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d... 44 5e-04
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ... 44 5e-04
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ... 44 5e-04
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] 44 5e-04
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa... 43 7e-04
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 43 7e-04
gi|66792814 retrotransposon gag domain containing 4 [Homo sapiens] 43 9e-04
gi|27262628 nuclear autoantigenic sperm protein isoform 2 [Homo ... 42 0.001
gi|27262634 nuclear autoantigenic sperm protein isoform 1 [Homo ... 42 0.001
gi|48255931 hepatoma-derived growth factor-related protein 2 iso... 42 0.001
gi|14249158 hepatoma-derived growth factor-related protein 2 iso... 42 0.001
gi|217330641 IWS1 homolog [Homo sapiens] 42 0.002
>gi|109826351 melanophilin isoform 2 [Homo sapiens]
Length = 572
Score = 1143 bits (2957), Expect = 0.0
Identities = 572/572 (100%), Positives = 572/572 (100%)
Query: 1 MGKKLDLSKLTDEEAQHVLEVVQRDFDLRRKEEERLEALKGKIKKESSKRELLSDTAHLN 60
MGKKLDLSKLTDEEAQHVLEVVQRDFDLRRKEEERLEALKGKIKKESSKRELLSDTAHLN
Sbjct: 1 MGKKLDLSKLTDEEAQHVLEVVQRDFDLRRKEEERLEALKGKIKKESSKRELLSDTAHLN 60
Query: 61 ETHCARCLQPYQLLVNSKRQCLECGLFTCKSCGRVHPEEQGWICDPCHLARVVKIGSLEW 120
ETHCARCLQPYQLLVNSKRQCLECGLFTCKSCGRVHPEEQGWICDPCHLARVVKIGSLEW
Sbjct: 61 ETHCARCLQPYQLLVNSKRQCLECGLFTCKSCGRVHPEEQGWICDPCHLARVVKIGSLEW 120
Query: 121 YYEHVKARFKRFGSAKVIRSLHGRLQGGAGPELISEERSGDSDQTDEDGEPGSEAQAQAQ 180
YYEHVKARFKRFGSAKVIRSLHGRLQGGAGPELISEERSGDSDQTDEDGEPGSEAQAQAQ
Sbjct: 121 YYEHVKARFKRFGSAKVIRSLHGRLQGGAGPELISEERSGDSDQTDEDGEPGSEAQAQAQ 180
Query: 181 PFGSKKKRLLSVHDFDFEGDSDDSTQPQGHSLHLSSVPEARDSPQSLTDESCSEKAAPHK 240
PFGSKKKRLLSVHDFDFEGDSDDSTQPQGHSLHLSSVPEARDSPQSLTDESCSEKAAPHK
Sbjct: 181 PFGSKKKRLLSVHDFDFEGDSDDSTQPQGHSLHLSSVPEARDSPQSLTDESCSEKAAPHK 240
Query: 241 AEGLEEADTGASGCHSHPEEQPTSISPSRHGALAELCPPGGSHRMALGTAAALGSNVIRN 300
AEGLEEADTGASGCHSHPEEQPTSISPSRHGALAELCPPGGSHRMALGTAAALGSNVIRN
Sbjct: 241 AEGLEEADTGASGCHSHPEEQPTSISPSRHGALAELCPPGGSHRMALGTAAALGSNVIRN 300
Query: 301 EQLPLQYLADVDTSDEESIRAHVMASHHSKRRGRASSESQGLGAGVRTEADVEEEALRRK 360
EQLPLQYLADVDTSDEESIRAHVMASHHSKRRGRASSESQGLGAGVRTEADVEEEALRRK
Sbjct: 301 EQLPLQYLADVDTSDEESIRAHVMASHHSKRRGRASSESQGLGAGVRTEADVEEEALRRK 360
Query: 361 LEELTSNVSDQETSSEEEEAKDEKAEPNRDKSVGPLPQADPEVGTAAHQTNRQEKSPQDP 420
LEELTSNVSDQETSSEEEEAKDEKAEPNRDKSVGPLPQADPEVGTAAHQTNRQEKSPQDP
Sbjct: 361 LEELTSNVSDQETSSEEEEAKDEKAEPNRDKSVGPLPQADPEVGTAAHQTNRQEKSPQDP 420
Query: 421 GDPVQYNRTTDEELSELEDRVAVTASEVQQAESEVSDIESRIAALRAAGLTVKPSGKPRR 480
GDPVQYNRTTDEELSELEDRVAVTASEVQQAESEVSDIESRIAALRAAGLTVKPSGKPRR
Sbjct: 421 GDPVQYNRTTDEELSELEDRVAVTASEVQQAESEVSDIESRIAALRAAGLTVKPSGKPRR 480
Query: 481 KSNLPIFLPRVAGKLGKRPEDPNADPSSEAKAMAVPYLLRRKFSNSLKSQGKDDDSFDRK 540
KSNLPIFLPRVAGKLGKRPEDPNADPSSEAKAMAVPYLLRRKFSNSLKSQGKDDDSFDRK
Sbjct: 481 KSNLPIFLPRVAGKLGKRPEDPNADPSSEAKAMAVPYLLRRKFSNSLKSQGKDDDSFDRK 540
Query: 541 SVYRGSLTQRNPNARKGMASHTFAKPVVAHQS 572
SVYRGSLTQRNPNARKGMASHTFAKPVVAHQS
Sbjct: 541 SVYRGSLTQRNPNARKGMASHTFAKPVVAHQS 572
>gi|13129108 melanophilin isoform 1 [Homo sapiens]
Length = 600
Score = 1128 bits (2918), Expect = 0.0
Identities = 572/600 (95%), Positives = 572/600 (95%), Gaps = 28/600 (4%)
Query: 1 MGKKLDLSKLTDEEAQHVLEVVQRDFDLRRKEEERLEALKGKIKKESSKRELLSDTAHLN 60
MGKKLDLSKLTDEEAQHVLEVVQRDFDLRRKEEERLEALKGKIKKESSKRELLSDTAHLN
Sbjct: 1 MGKKLDLSKLTDEEAQHVLEVVQRDFDLRRKEEERLEALKGKIKKESSKRELLSDTAHLN 60
Query: 61 ETHCARCLQPYQLLVNSKRQCLECGLFTCKSCGRVHPEEQGWICDPCHLARVVKIGSLEW 120
ETHCARCLQPYQLLVNSKRQCLECGLFTCKSCGRVHPEEQGWICDPCHLARVVKIGSLEW
Sbjct: 61 ETHCARCLQPYQLLVNSKRQCLECGLFTCKSCGRVHPEEQGWICDPCHLARVVKIGSLEW 120
Query: 121 YYEHVKARFKRFGSAKVIRSLHGRLQGGAGPELISEERSGDSDQTDEDGEPGSEAQAQAQ 180
YYEHVKARFKRFGSAKVIRSLHGRLQGGAGPELISEERSGDSDQTDEDGEPGSEAQAQAQ
Sbjct: 121 YYEHVKARFKRFGSAKVIRSLHGRLQGGAGPELISEERSGDSDQTDEDGEPGSEAQAQAQ 180
Query: 181 PFGSKKKRLLSVHDFDFEGDSDDSTQPQGHSLHLSSVPEARDSPQSLTDESCSEKAAPHK 240
PFGSKKKRLLSVHDFDFEGDSDDSTQPQGHSLHLSSVPEARDSPQSLTDESCSEKAAPHK
Sbjct: 181 PFGSKKKRLLSVHDFDFEGDSDDSTQPQGHSLHLSSVPEARDSPQSLTDESCSEKAAPHK 240
Query: 241 AEGLEEADTGASGCHSHPEEQPTSISPSRHGALAELCPPGGSHRMALGTAAALGSNVIRN 300
AEGLEEADTGASGCHSHPEEQPTSISPSRHGALAELCPPGGSHRMALGTAAALGSNVIRN
Sbjct: 241 AEGLEEADTGASGCHSHPEEQPTSISPSRHGALAELCPPGGSHRMALGTAAALGSNVIRN 300
Query: 301 EQLPLQYLADVDTSDEESIRAHVMASHHSKRRGRASSESQ-------------------- 340
EQLPLQYLADVDTSDEESIRAHVMASHHSKRRGRASSESQ
Sbjct: 301 EQLPLQYLADVDTSDEESIRAHVMASHHSKRRGRASSESQIFELNKHISAVECLLTYLEN 360
Query: 341 --------GLGAGVRTEADVEEEALRRKLEELTSNVSDQETSSEEEEAKDEKAEPNRDKS 392
GLGAGVRTEADVEEEALRRKLEELTSNVSDQETSSEEEEAKDEKAEPNRDKS
Sbjct: 361 TVVPPLAKGLGAGVRTEADVEEEALRRKLEELTSNVSDQETSSEEEEAKDEKAEPNRDKS 420
Query: 393 VGPLPQADPEVGTAAHQTNRQEKSPQDPGDPVQYNRTTDEELSELEDRVAVTASEVQQAE 452
VGPLPQADPEVGTAAHQTNRQEKSPQDPGDPVQYNRTTDEELSELEDRVAVTASEVQQAE
Sbjct: 421 VGPLPQADPEVGTAAHQTNRQEKSPQDPGDPVQYNRTTDEELSELEDRVAVTASEVQQAE 480
Query: 453 SEVSDIESRIAALRAAGLTVKPSGKPRRKSNLPIFLPRVAGKLGKRPEDPNADPSSEAKA 512
SEVSDIESRIAALRAAGLTVKPSGKPRRKSNLPIFLPRVAGKLGKRPEDPNADPSSEAKA
Sbjct: 481 SEVSDIESRIAALRAAGLTVKPSGKPRRKSNLPIFLPRVAGKLGKRPEDPNADPSSEAKA 540
Query: 513 MAVPYLLRRKFSNSLKSQGKDDDSFDRKSVYRGSLTQRNPNARKGMASHTFAKPVVAHQS 572
MAVPYLLRRKFSNSLKSQGKDDDSFDRKSVYRGSLTQRNPNARKGMASHTFAKPVVAHQS
Sbjct: 541 MAVPYLLRRKFSNSLKSQGKDDDSFDRKSVYRGSLTQRNPNARKGMASHTFAKPVVAHQS 600
>gi|59853352 myosin VIIA and Rab interacting protein [Homo sapiens]
Length = 859
Score = 171 bits (434), Expect = 1e-42
Identities = 110/291 (37%), Positives = 159/291 (54%), Gaps = 16/291 (5%)
Query: 1 MGKKLDLSKLTDEEAQHVLEVVQRDFDLRRKEEERLEALKGKIKKESSKRELLSDTAHLN 60
MG+KLDLS LTD+E +HVL+VVQRDF+LR+KEEERL LK K+ +E SK +LS
Sbjct: 1 MGRKLDLSGLTDDETEHVLQVVQRDFNLRKKEEERLSELKQKLDEEGSKCSILSKHQQFV 60
Query: 61 ETHCARCLQPYQLLVNSKRQCLECGLFTCKSCGRVHPEEQGWICDPCHLARVVKIGSLEW 120
E C RC P+ LVN+KRQC +C CKSC E+ W+C C AR+++ SLEW
Sbjct: 61 EHCCMRCCSPFTFLVNTKRQCGDCKFNVCKSCCSYQKHEKAWVCCVCQQARLLRAQSLEW 120
Query: 121 YYEHVKARFKRFGSAKVIRSLH--GRLQGGAGPELISEERSGDSDQTDEDGEPGSEAQAQ 178
+Y +VK+RFKRFGSAKV+++L+ RL+ GA +++ +S+ +E GS++
Sbjct: 121 FYNNVKSRFKRFGSAKVLKNLYRKHRLESGACFDILGGSLF-ESNLENEGSISGSDSTFY 179
Query: 179 AQPFGSKKKRLLSVH-DFDFEGDSDDSTQPQGHSLHLSSVPEA---RDSPQSLTDESCSE 234
Q G L+V E + ++ + + L EA RD + LT+E +
Sbjct: 180 RQSEGHSVMDTLAVALRVAEEAIEEAISKAEAYGDSLDKQNEASYLRDHKEELTEELATT 239
Query: 235 ------KAAPHKAEGLEEADTG---ASGCHSHPEEQPTSISPSRHGALAEL 276
+ K+E E + G C + ++ TS SP + A A L
Sbjct: 240 ILQKIIRKQKSKSEQQVEEEPGWPHPQSCSTKVADEGTSASPGGYRAPAAL 290
Score = 53.1 bits (126), Expect = 7e-07
Identities = 85/389 (21%), Positives = 150/389 (38%), Gaps = 66/389 (16%)
Query: 207 PQGHSLHLSSVPEARDSPQSL---TDESCSEKAAPHKAEGLEEADTGASGCHSHPEEQPT 263
P + L + +PQ T +S + APH + A P ++P+
Sbjct: 483 PAAEKMRLHGELDVNFNPQLASRETSDSSEPEEAPHTTDRRARRWRRARLGSEEPSKEPS 542
Query: 264 SISPSRHGALAELCPPGGSHRMALGTAAALGSNVIRNEQLPLQYLADVDTSDEESIRAHV 323
S S L +L +H+++ L I NE Q L D T ++ R +
Sbjct: 543 SPSAQ----LRDL----DTHQVS----DDLSETDISNEARDPQTLTDT-TEEKRRNRLYE 589
Query: 324 MASHHSKRRG----------RASSESQGLGAGVRTEADVEEEALRRKLEELTS------- 366
+A S++ + SE+Q + +E L++K ++
Sbjct: 590 LAMKMSEKETSSGEDQESEPKTESENQKESLSSEDNSQSVQEELKKKFSAVSLCNISTEV 649
Query: 367 ----NVSDQETSSEEEEAKDEKAEPNRDKSVGP-----------LPQADPEVGTAAHQTN 411
N +++ + + + P+R K + P L + V AA
Sbjct: 650 LKVINATEELIAGSTGPWESPQVPPDRQKGMFPRGTDQVRLDEQLTSLEENVYLAAGTVY 709
Query: 412 RQEKSPQDPGDPVQ--YNRTTDEELSELEDRVAVTASEVQQAESEVSDIESRIAALRAAG 469
E + D + ++ T + L++LED+VA A++V AE ++SDIESRI+AL AG
Sbjct: 710 GLETQLTELEDAARCIHSGTDETHLADLEDQVATAAAQVHHAELQISDIESRISALTIAG 769
Query: 470 LTVKPSGKPRRKSNLPIFLPRVAGKLGKRPEDPNADPS-SEAKAMAVPYLLRRKFSNSLK 528
L + P + R+ + +R + D S + + + P + K S
Sbjct: 770 LNIAPCVRFTRRRDQK-----------QRTQVQTIDTSRQQRRKLPAPPVKAEKIETSSV 818
Query: 529 SQGKDDDSFDRKSVYRGSLTQRNPNARKG 557
+ K +F+ + +GS T R RKG
Sbjct: 819 TTIK---TFNHNFILQGSSTNRT-KERKG 843
>gi|193804862 synaptotagmin-like 4 [Homo sapiens]
Length = 671
Score = 73.9 bits (180), Expect = 4e-13
Identities = 43/142 (30%), Positives = 72/142 (50%), Gaps = 8/142 (5%)
Query: 1 MGKKLDLSKLTDEEAQHVLEVVQRDFDLRRKEEERLEALKG---KIKKESSKRELLSDTA 57
M + LDLS L++EE +L V+QRD ++R+ +E+R+ LK +IK++ +KR +
Sbjct: 1 MSELLDLSFLSEEEKDLILSVLQRDEEVRKADEKRIRRLKNELLEIKRKGAKR----GSQ 56
Query: 58 HLNETHCARCLQPYQLLVNSKRQCLECGLFTCKSCGRVHPEEQGWICDPCHLARVVKIGS 117
H ++ CARC + L C C C+ C R+ W C C +K +
Sbjct: 57 HYSDRTCARCQESLGRLSPKTNTCRGCNHLVCRDC-RIQESNGTWRCKVCAKEIELKKAT 115
Query: 118 LEWYYEHVKARFKRFGSAKVIR 139
+W+Y+ RF +++IR
Sbjct: 116 GDWFYDQKVNRFAYRTGSEIIR 137
>gi|193804860 synaptotagmin-like 4 [Homo sapiens]
Length = 671
Score = 73.9 bits (180), Expect = 4e-13
Identities = 43/142 (30%), Positives = 72/142 (50%), Gaps = 8/142 (5%)
Query: 1 MGKKLDLSKLTDEEAQHVLEVVQRDFDLRRKEEERLEALKG---KIKKESSKRELLSDTA 57
M + LDLS L++EE +L V+QRD ++R+ +E+R+ LK +IK++ +KR +
Sbjct: 1 MSELLDLSFLSEEEKDLILSVLQRDEEVRKADEKRIRRLKNELLEIKRKGAKR----GSQ 56
Query: 58 HLNETHCARCLQPYQLLVNSKRQCLECGLFTCKSCGRVHPEEQGWICDPCHLARVVKIGS 117
H ++ CARC + L C C C+ C R+ W C C +K +
Sbjct: 57 HYSDRTCARCQESLGRLSPKTNTCRGCNHLVCRDC-RIQESNGTWRCKVCAKEIELKKAT 115
Query: 118 LEWYYEHVKARFKRFGSAKVIR 139
+W+Y+ RF +++IR
Sbjct: 116 GDWFYDQKVNRFAYRTGSEIIR 137
>gi|110227631 synaptotagmin-like 3 [Homo sapiens]
Length = 542
Score = 68.2 bits (165), Expect = 2e-11
Identities = 43/138 (31%), Positives = 63/138 (45%), Gaps = 1/138 (0%)
Query: 1 MGKKLDLSKLTDEEAQHVLEVVQRDFDLRRKEEERLEALKGKIKKESSKRELLSDTAHLN 60
M +++DLS L + E + +L+V+ RD ++ EEER LK ++ K +D H
Sbjct: 1 MAQEIDLSALKELEREAILQVLYRDQAVQNTEEERTRKLKTHLQHLRWKGAKNTDWEH-K 59
Query: 61 ETHCARCLQPYQLLVNSKRQCLECGLFTCKSCGRVHPEEQGWICDPCHLARVVKIGSLEW 120
E CARC Q L++ C C C C W C C R VKI + EW
Sbjct: 60 EKCCARCQQVLGFLLHRGAVCRGCSHRVCAQCRVFLRGTHAWKCTVCFEDRNVKIKTGEW 119
Query: 121 YYEHVKARFKRFGSAKVI 138
+YE +F G + +
Sbjct: 120 FYEERAKKFPTGGKHETV 137
>gi|254039650 synaptotagmin-like 5 isoform 1 [Homo sapiens]
Length = 730
Score = 66.2 bits (160), Expect = 8e-11
Identities = 51/191 (26%), Positives = 85/191 (44%), Gaps = 16/191 (8%)
Query: 5 LDLSKLTDEEAQHVLEVVQRDFDLRRKEEERLEALKGKI---KKESSKRELLSDTAHLNE 61
++LS L D E + +L V++RD L++ E++R+ LK ++ K+ S K + +
Sbjct: 8 INLSFLLDHEKEMILGVLKRDEYLKKVEDKRIRKLKNELLEAKRRSGKTQQEASRV---- 63
Query: 62 THCARCLQPYQLLVNSKRQCLECGLFTCKSCGRVHPEEQGWICDPCHLARVVKIGSLEWY 121
C C + L+ + C C L C+ C RV W C C ++I + EW+
Sbjct: 64 --CVHCHRNLGLIFDRGDPCQACSLRVCREC-RVAGPNGSWKCTVCDKIAQLRIITGEWF 120
Query: 122 YEHVKARFKRFG--SAKVIRSLHGRLQGGAGPELISEERSGDSDQTDEDGEPGSEAQAQA 179
+E RFK+ V+R R GA E+ D++++D G +A
Sbjct: 121 FEEKAKRFKQVNVLGTDVVRQSILRRSPGAEEVQSQEQTRQDAEKSDTSPVAGKKASHD- 179
Query: 180 QPFGSKKKRLL 190
G K+K L
Sbjct: 180 ---GPKRKGFL 187
>gi|254039648 synaptotagmin-like 5 isoform 2 [Homo sapiens]
Length = 752
Score = 66.2 bits (160), Expect = 8e-11
Identities = 51/191 (26%), Positives = 85/191 (44%), Gaps = 16/191 (8%)
Query: 5 LDLSKLTDEEAQHVLEVVQRDFDLRRKEEERLEALKGKI---KKESSKRELLSDTAHLNE 61
++LS L D E + +L V++RD L++ E++R+ LK ++ K+ S K + +
Sbjct: 8 INLSFLLDHEKEMILGVLKRDEYLKKVEDKRIRKLKNELLEAKRRSGKTQQEASRV---- 63
Query: 62 THCARCLQPYQLLVNSKRQCLECGLFTCKSCGRVHPEEQGWICDPCHLARVVKIGSLEWY 121
C C + L+ + C C L C+ C RV W C C ++I + EW+
Sbjct: 64 --CVHCHRNLGLIFDRGDPCQACSLRVCREC-RVAGPNGSWKCTVCDKIAQLRIITGEWF 120
Query: 122 YEHVKARFKRFG--SAKVIRSLHGRLQGGAGPELISEERSGDSDQTDEDGEPGSEAQAQA 179
+E RFK+ V+R R GA E+ D++++D G +A
Sbjct: 121 FEEKAKRFKQVNVLGTDVVRQSILRRSPGAEEVQSQEQTRQDAEKSDTSPVAGKKASHD- 179
Query: 180 QPFGSKKKRLL 190
G K+K L
Sbjct: 180 ---GPKRKGFL 187
>gi|20270305 synaptotagmin-like 5 isoform 1 [Homo sapiens]
Length = 730
Score = 66.2 bits (160), Expect = 8e-11
Identities = 51/191 (26%), Positives = 85/191 (44%), Gaps = 16/191 (8%)
Query: 5 LDLSKLTDEEAQHVLEVVQRDFDLRRKEEERLEALKGKI---KKESSKRELLSDTAHLNE 61
++LS L D E + +L V++RD L++ E++R+ LK ++ K+ S K + +
Sbjct: 8 INLSFLLDHEKEMILGVLKRDEYLKKVEDKRIRKLKNELLEAKRRSGKTQQEASRV---- 63
Query: 62 THCARCLQPYQLLVNSKRQCLECGLFTCKSCGRVHPEEQGWICDPCHLARVVKIGSLEWY 121
C C + L+ + C C L C+ C RV W C C ++I + EW+
Sbjct: 64 --CVHCHRNLGLIFDRGDPCQACSLRVCREC-RVAGPNGSWKCTVCDKIAQLRIITGEWF 120
Query: 122 YEHVKARFKRFG--SAKVIRSLHGRLQGGAGPELISEERSGDSDQTDEDGEPGSEAQAQA 179
+E RFK+ V+R R GA E+ D++++D G +A
Sbjct: 121 FEEKAKRFKQVNVLGTDVVRQSILRRSPGAEEVQSQEQTRQDAEKSDTSPVAGKKASHD- 179
Query: 180 QPFGSKKKRLL 190
G K+K L
Sbjct: 180 ---GPKRKGFL 187
>gi|194272142 myosin IXB isoform 2 [Homo sapiens]
Length = 2022
Score = 57.8 bits (138), Expect = 3e-08
Identities = 124/557 (22%), Positives = 212/557 (38%), Gaps = 66/557 (11%)
Query: 10 LTDEEAQHVLEVVQRDFDLRRKEEERLEALKGKIKKESSKRELLSDTAHLNETHCARCLQ 69
L ++AQ EV+ + + ++ + K K+ + ++R+ L +T H LQ
Sbjct: 905 LLPKDAQPCREVISTLLEKMKIDKRNYQIGKTKVFLKETERQALQETLHREVVRKILLLQ 964
Query: 70 PYQLLVNSKRQCLEC--GLFTCKSCGRVHPEEQGWICDPCHLARVVKIGSLEWYYEHVKA 127
+ +V +R L+ T ++C R + + A V S Y++
Sbjct: 965 SWFRMVLERRHFLQMKRAAVTIQACWRSYRVRRALERTQ---AAVYLQASWRGYWQRKLY 1021
Query: 128 RFKRFGSAKVIRSLHGRLQGGAGPELISEERSGDSDQTD--EDGEPGSEAQAQAQPFGSK 185
R ++ ++ G LQ + ++ISE++ + + + E G+E Q Q G +
Sbjct: 1022 RHQKQSIIRLQSLCRGHLQRKSFSQMISEKQKAEEKEREALEAARAGAEEGGQGQAAGGQ 1081
Query: 186 KKRLLSVHDFDFEGDSDDSTQPQGHSLHLSSVPEARDSPQSLTDESCSEKAAPHKAEGLE 245
+ ++ +P HL+S PE + S +S + S EK AP + L
Sbjct: 1082 QV-------------AEQGPEPAEDGGHLASEPEVQPSDRSPLEHSSPEKEAPSPEKTLP 1128
Query: 246 EADTGASGCHSHPEEQPTSIS--PSRHGALAELCPPGGSHRMALGTAAALGSNVIR-NEQ 302
T A+ H E+ P+S SR E H + +AL R ++
Sbjct: 1129 PQKTVAAESH---EKVPSSREKRESRRQRGLEHVKFQNKHIQSCKEESALREPSRRVTQE 1185
Query: 303 LPLQYLADVDTSDEESIRAHVMASHHSKRRGRASSESQGLGAG---VRTEADVEEEALR- 358
+ L D S E+ V + + + + + Q + G TE + + R
Sbjct: 1186 QGVSLLEDKKESREDETLLVVETEAENTSQKQPTEQPQAMAVGKVSEETEKTLPSGSPRP 1245
Query: 359 RKLEELTSNVSDQETSSEEEEAKDEKAEPNRDKSVGPLPQADPEVGTAAHQTNRQEKSPQ 418
+LE TS D S + E E DKS P P V QEK P
Sbjct: 1246 GQLERPTSLALDSRVSPPAPGSAPETPE---DKS---KPCGSPRV---------QEK-PD 1289
Query: 419 DPGDPVQYNRTTDEE--LSELE---DRVAVTASEVQQAESEVSDIESRIAALRAAGLTVK 473
PG Q R D E S +E + V A+ S+ D+ R RA G +
Sbjct: 1290 SPGGSTQIQRYLDAERLASAVELWRGKKLVAAASPSAMLSQSLDLSDR---HRATGAALT 1346
Query: 474 PSGKPRRK---SNLPIFLPRVAGKLGKRPEDPNADPSSEAKAMAVPYLLRRK--FSNSLK 528
P+ + R S++ LP +A P A+ + ++ P + ++K ++SL
Sbjct: 1347 PTEERRTSFSTSDVSKLLPSLA------KAQPAAETTDGERSAKKPAVQKKKPGDASSLP 1400
Query: 529 SQGKDDDS-FDRKSVYR 544
G S D KS ++
Sbjct: 1401 DAGLSPGSQVDSKSTFK 1417
>gi|33356170 myosin IXB isoform 1 [Homo sapiens]
Length = 2157
Score = 57.8 bits (138), Expect = 3e-08
Identities = 124/557 (22%), Positives = 212/557 (38%), Gaps = 66/557 (11%)
Query: 10 LTDEEAQHVLEVVQRDFDLRRKEEERLEALKGKIKKESSKRELLSDTAHLNETHCARCLQ 69
L ++AQ EV+ + + ++ + K K+ + ++R+ L +T H LQ
Sbjct: 905 LLPKDAQPCREVISTLLEKMKIDKRNYQIGKTKVFLKETERQALQETLHREVVRKILLLQ 964
Query: 70 PYQLLVNSKRQCLEC--GLFTCKSCGRVHPEEQGWICDPCHLARVVKIGSLEWYYEHVKA 127
+ +V +R L+ T ++C R + + A V S Y++
Sbjct: 965 SWFRMVLERRHFLQMKRAAVTIQACWRSYRVRRALERTQ---AAVYLQASWRGYWQRKLY 1021
Query: 128 RFKRFGSAKVIRSLHGRLQGGAGPELISEERSGDSDQTD--EDGEPGSEAQAQAQPFGSK 185
R ++ ++ G LQ + ++ISE++ + + + E G+E Q Q G +
Sbjct: 1022 RHQKQSIIRLQSLCRGHLQRKSFSQMISEKQKAEEKEREALEAARAGAEEGGQGQAAGGQ 1081
Query: 186 KKRLLSVHDFDFEGDSDDSTQPQGHSLHLSSVPEARDSPQSLTDESCSEKAAPHKAEGLE 245
+ ++ +P HL+S PE + S +S + S EK AP + L
Sbjct: 1082 QV-------------AEQGPEPAEDGGHLASEPEVQPSDRSPLEHSSPEKEAPSPEKTLP 1128
Query: 246 EADTGASGCHSHPEEQPTSIS--PSRHGALAELCPPGGSHRMALGTAAALGSNVIR-NEQ 302
T A+ H E+ P+S SR E H + +AL R ++
Sbjct: 1129 PQKTVAAESH---EKVPSSREKRESRRQRGLEHVKFQNKHIQSCKEESALREPSRRVTQE 1185
Query: 303 LPLQYLADVDTSDEESIRAHVMASHHSKRRGRASSESQGLGAG---VRTEADVEEEALR- 358
+ L D S E+ V + + + + + Q + G TE + + R
Sbjct: 1186 QGVSLLEDKKESREDETLLVVETEAENTSQKQPTEQPQAMAVGKVSEETEKTLPSGSPRP 1245
Query: 359 RKLEELTSNVSDQETSSEEEEAKDEKAEPNRDKSVGPLPQADPEVGTAAHQTNRQEKSPQ 418
+LE TS D S + E E DKS P P V QEK P
Sbjct: 1246 GQLERPTSLALDSRVSPPAPGSAPETPE---DKS---KPCGSPRV---------QEK-PD 1289
Query: 419 DPGDPVQYNRTTDEE--LSELE---DRVAVTASEVQQAESEVSDIESRIAALRAAGLTVK 473
PG Q R D E S +E + V A+ S+ D+ R RA G +
Sbjct: 1290 SPGGSTQIQRYLDAERLASAVELWRGKKLVAAASPSAMLSQSLDLSDR---HRATGAALT 1346
Query: 474 PSGKPRRK---SNLPIFLPRVAGKLGKRPEDPNADPSSEAKAMAVPYLLRRK--FSNSLK 528
P+ + R S++ LP +A P A+ + ++ P + ++K ++SL
Sbjct: 1347 PTEERRTSFSTSDVSKLLPSLA------KAQPAAETTDGERSAKKPAVQKKKPGDASSLP 1400
Query: 529 SQGKDDDS-FDRKSVYR 544
G S D KS ++
Sbjct: 1401 DAGLSPGSQVDSKSTFK 1417
>gi|219804203 rabphilin 3A homolog isoform 1 [Homo sapiens]
Length = 694
Score = 47.0 bits (110), Expect = 5e-05
Identities = 67/312 (21%), Positives = 119/312 (38%), Gaps = 41/312 (13%)
Query: 9 KLTDEEAQHVLEVVQRDFDLRRKEEERLEALKGKIKKESSKRELLSDTAHLNETHCARCL 68
+LTDEE + + V+ R + E+ER+ L ++ E+ ++ + D + C C
Sbjct: 49 ELTDEEKEIINRVIARAEKMEEMEQERIGRLVDRL--ENMRKNVAGDGVN----RCILCG 102
Query: 69 QPYQLLVNSKRQCLECGLFTCKSCG-----RVHPEEQGWICDPCHLARVVKIGSLEWYYE 123
+ +L ++ C +C C CG R+H W+C C R V S W+++
Sbjct: 103 EQLGMLGSACVVCEDCKKNVCTKCGVETNNRLH---SVWLCKICIEQREVWKRSGAWFFK 159
Query: 124 HVKAR-------FKRFGSAKVIRSLHGRLQGGAGPEL--------ISEERSGDSDQTDED 168
+ K+ + + Q P+ SE+R G +T D
Sbjct: 160 GFPKQVLPQPMPIKKTKPQQPVSEPAAPEQPAPEPKHPARAPARGDSEDRRGPGQKTGPD 219
Query: 169 --GEPGSEAQAQAQPFGSKKKRLLSVHD---FDFEGDSDDSTQPQGHSLHLSSVPEARDS 223
PG S+ + S D +D G + DS++ +SV +R +
Sbjct: 220 PASAPGRGNYGPPVRRASEARMSSSSRDSESWDHSGGAGDSSRSPAGLRRANSVQASRPA 279
Query: 224 PQSLTDESCSEKAAPHKAEGLEEADTGASGCHSHPEEQPTSISPSRHGALAELCPPGGSH 283
P S+ + + P G + G P+++P ++PS G A PP
Sbjct: 280 PGSVQSPAPPQPGQPGTPGG---SRPGPGPAGRFPDQKP-EVAPSDPGTTA---PPREER 332
Query: 284 RMALGTAAALGS 295
+G A+G+
Sbjct: 333 TGGVGGYPAVGA 344
>gi|45267837 rabphilin 3A homolog isoform 2 [Homo sapiens]
Length = 690
Score = 47.0 bits (110), Expect = 5e-05
Identities = 67/312 (21%), Positives = 119/312 (38%), Gaps = 41/312 (13%)
Query: 9 KLTDEEAQHVLEVVQRDFDLRRKEEERLEALKGKIKKESSKRELLSDTAHLNETHCARCL 68
+LTDEE + + V+ R + E+ER+ L ++ E+ ++ + D + C C
Sbjct: 45 ELTDEEKEIINRVIARAEKMEEMEQERIGRLVDRL--ENMRKNVAGDGVN----RCILCG 98
Query: 69 QPYQLLVNSKRQCLECGLFTCKSCG-----RVHPEEQGWICDPCHLARVVKIGSLEWYYE 123
+ +L ++ C +C C CG R+H W+C C R V S W+++
Sbjct: 99 EQLGMLGSACVVCEDCKKNVCTKCGVETNNRLH---SVWLCKICIEQREVWKRSGAWFFK 155
Query: 124 HVKAR-------FKRFGSAKVIRSLHGRLQGGAGPEL--------ISEERSGDSDQTDED 168
+ K+ + + Q P+ SE+R G +T D
Sbjct: 156 GFPKQVLPQPMPIKKTKPQQPVSEPAAPEQPAPEPKHPARAPARGDSEDRRGPGQKTGPD 215
Query: 169 --GEPGSEAQAQAQPFGSKKKRLLSVHD---FDFEGDSDDSTQPQGHSLHLSSVPEARDS 223
PG S+ + S D +D G + DS++ +SV +R +
Sbjct: 216 PASAPGRGNYGPPVRRASEARMSSSSRDSESWDHSGGAGDSSRSPAGLRRANSVQASRPA 275
Query: 224 PQSLTDESCSEKAAPHKAEGLEEADTGASGCHSHPEEQPTSISPSRHGALAELCPPGGSH 283
P S+ + + P G + G P+++P ++PS G A PP
Sbjct: 276 PGSVQSPAPPQPGQPGTPGG---SRPGPGPAGRFPDQKP-EVAPSDPGTTA---PPREER 328
Query: 284 RMALGTAAALGS 295
+G A+G+
Sbjct: 329 TGGVGGYPAVGA 340
>gi|60097902 filaggrin [Homo sapiens]
Length = 4061
Score = 44.7 bits (104), Expect = 2e-04
Identities = 76/344 (22%), Positives = 125/344 (36%), Gaps = 41/344 (11%)
Query: 147 GGAGPELIS-----EERSGDSDQTD--EDGEPGSEAQA-------QAQPFGSKKKRLLSV 192
G +GP S EE+SGD + EP + A + Q + GSK R
Sbjct: 1533 GQSGPRSASRQTRNEEQSGDGSRHSGSRHHEPSTRAGSSRHSQVGQGESAGSKTSRRQGS 1592
Query: 193 ---HDFDFEGDSDDSTQPQGHSLHLSSVPEARD-------SPQSLTDESCSE--KAAPHK 240
D D EG S+DS + + S + AR+ +P+S ++ S A +
Sbjct: 1593 SVSQDRDSEGHSEDSER-RSESASRNHYGSAREQSRHGSRNPRSHQEDRASHGHSAESSR 1651
Query: 241 AEGLEEADTGASGCHSHPEEQPTSISPSRHGA----LAELCPPGGSHRMALGTAAALGSN 296
G A+T + G + +EQ S RHG+ A+ G+ R + N
Sbjct: 1652 QSGTRHAETSSGGQAASSQEQARSSPGERHGSRHQQSADSSTDSGTGRRQDSSVVGDSGN 1711
Query: 297 VIRNEQLPLQYLADVDTSDEESIRAHVMA-----SHHSKRRGRASSESQGLGAGVRTEAD 351
+ + SD +S+ AH A SH RG+ S E G +
Sbjct: 1712 RGSSGSQASDSEGHSEESDTQSVSAHGQAGPHQQSHQESTRGQ-SGERSGRSGSFLYQVS 1770
Query: 352 VEEEALRRKLEELTSNVSDQETSSEEEEAKDEKAEPNRDKSVGPLPQADPEVGTAAHQTN 411
E++ T + S E+A+D + + + P Q +
Sbjct: 1771 THEQS--ESAHGRTGPSTGGRQRSRHEQARDSSRHSASQEGQDTI-RGHPGSSRGGRQGS 1827
Query: 412 RQEKSPQDPG-DPVQYNRTTDEELSELEDRVAVTASEVQQAESE 454
E+S G ++ TT +E S++ + + S +Q +E
Sbjct: 1828 HYEQSVDSSGHSGSHHSHTTSQERSDVSRGQSGSRSVSRQTRNE 1871
Score = 42.4 bits (98), Expect = 0.001
Identities = 50/216 (23%), Positives = 81/216 (37%), Gaps = 33/216 (15%)
Query: 155 SEERSGDSDQTDEDGEPGSEAQAQAQ--------------PFGSKKKRLLSVHDFDFEGD 200
+EE+SGD T G EA +QA P S+ + D D +G
Sbjct: 573 NEEQSGDG--TRHSGSRHHEASSQADSSRHSQVGQGQSSGPRTSRNQGSSVSQDSDSQGH 630
Query: 201 SDDSTQPQG---HSLHLSSVPEARDS---PQSLTDESC--SEKAAPHKAEGLEEADTGAS 252
S+DS + G + H S+ ++RD P+S ++ A + G +S
Sbjct: 631 SEDSERWSGSASRNHHGSAQEQSRDGSRHPRSHHEDRAGHGHSADSSRKSGTRHTQNSSS 690
Query: 253 GCHSHPEEQPTSISPSRHGALAELCPPGGSHRMALGTAAALGSNVIRNE-------QLPL 305
G + EQ S + RHG+ +L S GT S+ +R+
Sbjct: 691 GQAASSHEQARSSAGERHGSRHQLQSADSSRHS--GTGHGQASSAVRDSGHRGSSGSQAT 748
Query: 306 QYLADVDTSDEESIRAHVMASHHSKRRGRASSESQG 341
+ SD +S+ H A HH + ++ + G
Sbjct: 749 DSEGHSEDSDTQSVSGHGQAGHHQQSHQESARDRSG 784
Score = 42.0 bits (97), Expect = 0.002
Identities = 55/232 (23%), Positives = 78/232 (33%), Gaps = 23/232 (9%)
Query: 133 GSAKVIRSLHGRLQGGAGPELISEERSGDSDQTDEDGEPGSEAQAQAQPFGSKKKRLLSV 192
GS R Q G G S Q D S A P S+ +
Sbjct: 3481 GSRSASRQTRNDEQSGDGSRHSWSHHHEASTQADSSRHSQSGQGQSAGPRTSRNQGSSVS 3540
Query: 193 HDFDFEGDSDDSTQPQGHSL--HLSSVPE-ARDSPQSLTDESCSEKAAPHKAE-----GL 244
D D +G S+DS + G + H S E +RD + T H AE G
Sbjct: 3541 QDSDSQGHSEDSERWSGSASRNHRGSAQEQSRDGSRHPTSHHEDRAGHGHSAESSRQSGT 3600
Query: 245 EEADTGASGCHSHPEEQPTSISPSRHGALAELCPPGGSHRMALGTAAALGSNVIRNE--- 301
A+ + G + EQ S + RHG+ + H G S+ +R+
Sbjct: 3601 HHAENSSGGQAASSHEQARSSAGERHGSHHQQSADSSRHS---GIGHGQASSAVRDSGHR 3657
Query: 302 ----QLPLQYLADVDTSDEESIRAHVMA-----SHHSKRRGRASSESQGLGA 344
+ SD +S+ AH A SH RGR++ S G+
Sbjct: 3658 GSSGSQASDSEGHSEDSDTQSVSAHGQAGPHQQSHQESTRGRSAGRSGRSGS 3709
Score = 41.6 bits (96), Expect = 0.002
Identities = 70/325 (21%), Positives = 119/325 (36%), Gaps = 27/325 (8%)
Query: 152 ELISEERSGDSDQTDEDGEPGSE--AQAQAQPFGSKKKRLLSV-HDFDFEGDSDDSTQPQ 208
++ RS D + + E +Q Q ++K+R V D D EG S+DS +
Sbjct: 255 KIYERSRSSDGKSSSQVNRSRHENTSQVPLQESRTRKRRGSRVSQDRDSEGHSEDSERHS 314
Query: 209 GHSL---HLSSVPEARDS---PQSLTDESCSE--KAAPHKAEGLEEADTGASGCHSHPEE 260
G + H S+ ++RD P+S ++ S A + G A+T + G + E
Sbjct: 315 GSASRNHHGSAWEQSRDGSRHPRSHDEDRASHGHSADSSRQSGTRHAETSSRGQTASSHE 374
Query: 261 QPTSISPSRHGALAELCPPGGSHRMALGTAAALGSNVIRNEQLPLQYLAD-----VDTSD 315
Q S RHG+ + H A G A + R + A + SD
Sbjct: 375 QARSSPGERHGSGHQQSADSSRH-SATGRGQASSAVSDRGHRGSSGSQASDSEGHSENSD 433
Query: 316 EESIRAHVMA-----SHHSKRRGRASSESQGLGAGVRTEADVEEEALRRKLEELTSNVSD 370
+S+ H A SH RGR+ S G+ + + E+ T +
Sbjct: 434 TQSVSGHGKAGLRQQSHQESTRGRSGERSGRSGSSLYQVSTHEQP---DSAHGRTGTSTG 490
Query: 371 QETSSEEEEAKDEKAEPNRDKSVGPLPQADPEVGTAAHQTNRQEKSPQDPG-DPVQYNRT 429
S E+A+D + + + P Q + E+S G ++ T
Sbjct: 491 GRQGSHHEQARDSSRHSASQEGQDTI-RGHPGSSRGGRQGSHHEQSVNRSGHSGSHHSHT 549
Query: 430 TDEELSELEDRVAVTASEVQQAESE 454
T + S+ + + S +Q +E
Sbjct: 550 TSQGRSDASHGQSGSRSASRQTRNE 574
Score = 40.0 bits (92), Expect = 0.006
Identities = 61/260 (23%), Positives = 98/260 (37%), Gaps = 38/260 (14%)
Query: 155 SEERSGDSDQ----------TDEDGEPGSEAQAQAQPFGSKKKRLLSV---HDFDFEGDS 201
+EE+SGDS + T D S+A Q Q GS++ R D D EG S
Sbjct: 3167 NEEQSGDSSRHSVSRHHEASTHADISRHSQA-VQGQSEGSRRSRRQGSSVSQDSDSEGHS 3225
Query: 202 DDSTQPQGHSL--HLSSVPEARDSPQSLTDESCSEKAAPH-------KAEGLEEADTGAS 252
+DS + G + H SV E + S S E A H + G A+T +
Sbjct: 3226 EDSERWSGSASRNHRGSVQE-QSRHGSRHPRSHHEDRAGHGHSADRSRQSGTRHAETSSG 3284
Query: 253 GCHSHPEEQPTSISPSRHGALAELCPPGGSHRMALGTAAALGSNVIRNEQ-------LPL 305
G + EQ S RHG+ + H G S+ +R+ +
Sbjct: 3285 GQAASSHEQARSSPGERHGSRHQQSADSSRHS---GIPRGQASSAVRDSRHWGSSGSQAS 3341
Query: 306 QYLADVDTSDEESIRAHVMASHHSKRRGRASSESQGLGAGVRTEADVEEEALRRKLEEL- 364
+ SD +S+ H A H + ++ + G G R+ + + + + + E
Sbjct: 3342 DSEGHSEESDTQSVSGHGQAGPHQQSHQESARDRSG-GRSGRSGSFLYQVSTHEQSESAH 3400
Query: 365 --TSNVSDQETSSEEEEAKD 382
T + + S E+A+D
Sbjct: 3401 GRTRTSTGRRQGSHHEQARD 3420
Score = 31.6 bits (70), Expect = 2.1
Identities = 61/314 (19%), Positives = 110/314 (35%), Gaps = 31/314 (9%)
Query: 161 DSDQTDEDGEPGSEAQAQAQPFGSKKKRLLSVHDFDFEGDSDDSTQPQGHSL--HLSSVP 218
D + + G+ SE ++ GS + D D EG S+DS + G + H S
Sbjct: 921 DISRHSQAGQGQSEGSRTSRRQGSSVSQ-----DSDSEGHSEDSERWSGSASRNHRGSAQ 975
Query: 219 EARDSPQSLTDESCSEKAAPH-------KAEGLEEADTGASGCHSHPEEQPTSISPSRHG 271
E + S S E A H + G A+T + G + EQ S RHG
Sbjct: 976 E-QSRHGSRHPRSHHEDRAGHGHSADSSRQSGTPHAETSSGGQAASSHEQARSSPGERHG 1034
Query: 272 ALAELCPPGGSHRMALGTAAALGSNVIRNE-------QLPLQYLADVDTSDEESIRAHVM 324
+ + H G S+ +R+ + SD +S+ H
Sbjct: 1035 SRHQQSADSSRHS---GIPRRQASSAVRDSGHWGSSGSQASDSEGHSEESDTQSVSGHGQ 1091
Query: 325 ASHHSKRRGRASSESQGLGAGVRTEADVEEEALRRKLEEL---TSNVSDQETSSEEEEAK 381
H + ++ + G G R+ + + + + + E T + + S E+A+
Sbjct: 1092 DGPHQQSHQESARDWSG-GRSGRSGSFIYQVSTHEQSESAHGRTRTSTGRRQGSHHEQAR 1150
Query: 382 DEKAEPNRDKSVGPLPQADPEVGTAAHQTNRQEKSPQDPG-DPVQYNRTTDEELSELEDR 440
D + + +A P Q + E+S G ++ TT + S+
Sbjct: 1151 DSSRHSASQEGQDTI-RAHPGSRRGGRQGSHHEQSVDRSGHSGSHHSHTTSQGRSDASHG 1209
Query: 441 VAVTASEVQQAESE 454
+ + S +Q +
Sbjct: 1210 QSGSRSASRQTRKD 1223
>gi|15011902 synaptotagmin-like 2 isoform a [Homo sapiens]
Length = 910
Score = 44.3 bits (103), Expect = 3e-04
Identities = 21/48 (43%), Positives = 33/48 (68%)
Query: 5 LDLSKLTDEEAQHVLEVVQRDFDLRRKEEERLEALKGKIKKESSKREL 52
+DLS LT+EE + +++V+QRD L+R EEER+ L KIK + + +
Sbjct: 2 IDLSFLTEEEQEAIMKVLQRDAALKRAEEERVRHLPEKIKDDQQLKNM 49
>gi|244790020 synaptotagmin-like 2 isoform i [Homo sapiens]
Length = 935
Score = 44.3 bits (103), Expect = 3e-04
Identities = 21/48 (43%), Positives = 33/48 (68%)
Query: 5 LDLSKLTDEEAQHVLEVVQRDFDLRRKEEERLEALKGKIKKESSKREL 52
+DLS LT+EE + +++V+QRD L+R EEER+ L KIK + + +
Sbjct: 2 IDLSFLTEEEQEAIMKVLQRDAALKRAEEERVRHLPEKIKDDQQLKNM 49
>gi|244790013 synaptotagmin-like 2 isoform g [Homo sapiens]
Length = 934
Score = 44.3 bits (103), Expect = 3e-04
Identities = 21/48 (43%), Positives = 33/48 (68%)
Query: 5 LDLSKLTDEEAQHVLEVVQRDFDLRRKEEERLEALKGKIKKESSKREL 52
+DLS LT+EE + +++V+QRD L+R EEER+ L KIK + + +
Sbjct: 2 IDLSFLTEEEQEAIMKVLQRDAALKRAEEERVRHLPEKIKDDQQLKNM 49
>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
[Homo sapiens]
Length = 1451
Score = 43.5 bits (101), Expect = 5e-04
Identities = 80/339 (23%), Positives = 132/339 (38%), Gaps = 52/339 (15%)
Query: 155 SEERSGDSDQTDEDGEPG-SEAQAQAQPFGSKKKRLLSVHDFDFEGDSDDSTQPQGHSLH 213
SE+ S SD+TD +G+P AQ +A +K+ + D + Q +G +L
Sbjct: 200 SEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGK-VGDVTPQVKGGAL- 257
Query: 214 LSSVPEARDSPQSLTDESCSEKAAPHKAEGLEEADTGASGCHSHPEEQPTSISPSRHGAL 273
P A+ + + + SE EG E + +G S + + A
Sbjct: 258 ----PPAKRAKKPEEESESSE-------EGSESEEEAPAGTRSQVKASEKILQVRAASAP 306
Query: 274 AELCPPGGSHRMALGTAAALGSNVIRNEQLPLQYLADVDTSDEESIRAHVMASHHSKRRG 333
A+ P G+ G A A+ S + + ++SD E A +K G
Sbjct: 307 AKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASG 366
Query: 334 RAS---------SESQGLGA-----GVRTEADVEEEALRRKLEELTSNVSDQETSSEEEE 379
+ S ES GA G A + +A +R+ D ++SSEE +
Sbjct: 367 KTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKRE--------EDSQSSSEESD 418
Query: 380 AKDEKAEPNRDKSVGPLPQADPEVGTAAHQTNRQEKSPQDPGDPVQYNRTTDEELSELED 439
+++E P + K G PQ A ++ R+ +P P R T ++++
Sbjct: 419 SEEE--APAQAKPSGKAPQV-RAASAPAKESPRKGAAPAPP-------RKTGPAAAQVQ- 467
Query: 440 RVAVTASEVQQAESEVSDIE-SRIAALRAAGLTVKPSGK 477
E ++ SE SD + +AA+ AA VKP GK
Sbjct: 468 --VGKQEEDSRSSSEESDSDREALAAMNAA--QVKPLGK 502
Score = 35.8 bits (81), Expect = 0.11
Identities = 74/345 (21%), Positives = 128/345 (37%), Gaps = 60/345 (17%)
Query: 155 SEERSGDSDQTDEDGEPGSEAQAQAQPFGSKKKRLLS-VHDFDFEGDSDDSTQPQGHSL- 212
SE+ S S ++EDGE A++ G R + V + E DD P L
Sbjct: 1108 SEDSSDSSSGSEEDGEGPQGAKSAHTLVGPTPSRTETLVEETAAESSEDDVVAPSQSLLS 1167
Query: 213 -------------------HLSSVPEARDSPQSLTDESCSEKAAPHKAEGLEEADTG--- 250
L S P + + D ++A P +A G+ TG
Sbjct: 1168 GYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKE 1227
Query: 251 -ASGCHSHPEEQPTSISPSRHGALAELCPPGGSHRMALG-----TAAALGSNVIR--NEQ 302
ASG +P + + + L + LG A + ++V++ E
Sbjct: 1228 AASGTTPQKSRKPKKGAGNPQASTLAL--QSNITQCLLGQPWPLNEAQVQASVVKVLTEL 1285
Query: 303 LPLQYLADVDTSDEES-----IRAHVMASHHSKRRGRASSESQGLGAGVRTEADVEEEAL 357
L + VDT+ E S R ++ R S + + LGAG EA V E
Sbjct: 1286 LEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKT 1345
Query: 358 ------RRKLEELTSNVSDQ--ETSSEEEEAKDEKAEPNRDKSVGPLPQADPEVGTAAHQ 409
+ K ++ + +V ++ + S + AKDE E K +G + E G ++
Sbjct: 1346 STTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDE-PEEELQKGMGTV-----EGGDQSNP 1399
Query: 410 TNRQEKSPQDPGDPVQYNRTTDEELSELEDRVAVTASEVQQAESE 454
+++EK D R D+E E + + +++ ++ S+
Sbjct: 1400 KSKKEKKKSD-------KRKKDKEKKEKKKKAKKASTKDSESPSQ 1437
Score = 34.7 bits (78), Expect = 0.24
Identities = 64/300 (21%), Positives = 106/300 (35%), Gaps = 54/300 (18%)
Query: 146 QGGAGPELISEERSGDSDQTDEDGEPGSEAQAQAQPFGSKKKRLLSVHDFDFEGDSDDST 205
Q GPE E SG S++ + D E +E AQ +P G
Sbjct: 859 QAQTGPE----EDSGSSEE-ESDSEEEAETLAQVKPSG---------------------- 891
Query: 206 QPQGHSLHLSSVPEARDSPQSLTDESCSEKAAPHKAEGLEEADTGASGCHSHPE-EQPTS 264
+ H + + P A++SP+ + K P A+ ++ D+G+S S + E P +
Sbjct: 892 --KTHQIRAALAP-AKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAA 948
Query: 265 ISPSRHGALAELCPP---GGSHRMALGTAAALGSNVIRNEQLPLQYLADVDTSDEESIRA 321
++ ++ + PP +R G AA P Q A + +
Sbjct: 949 VTSAQ-----VIKPPLIFVDPNRSPAGPAAT-----------PAQAQAASTPRKARASES 992
Query: 322 HVMASHHSKRRGRASSESQGLGAGVRTEADVEEEALRR--KLEELTSNVSDQETSSEEEE 379
+S +Q L G+RT A R + S +E+S +
Sbjct: 993 TARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDG 1052
Query: 380 AKDEKAEPNRDKSVGPLPQADPEVGTAAHQTNRQEKSPQDPGDPVQYNRTTDEELSELED 439
K E D +VG LP P+ + + + + P+ P VQ E + ED
Sbjct: 1053 KKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLP--EVQQATKAPESSDDSED 1110
Score = 33.1 bits (74), Expect = 0.71
Identities = 80/380 (21%), Positives = 127/380 (33%), Gaps = 84/380 (22%)
Query: 147 GGAGPELISEE---RSGDSDQTDEDGEPGSEAQAQAQPFGSKKKRLLSVHDFDFEGDSDD 203
G GP + + R DS + E+ + EA AQA+P G
Sbjct: 392 GKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGK------------------- 432
Query: 204 STQPQGHSLHLSSVPEARDSPQSLTDESCSEKAAPHKAE---GLEEADTGASGCHSHPEE 260
PQ + +S P A++SP+ + K P A+ G +E D+ +S S +
Sbjct: 433 --APQ---VRAASAP-AKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDR 486
Query: 261 QPTSISPSRHGALAELCPPGGSHR------MALGTAAALGSNVIRNEQLPLQYLADVDTS 314
+ + + A++ P G S + M +G V + P A V
Sbjct: 487 EALAAMNA-----AQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKW 541
Query: 315 DEESIRAHVMASHHSKRRGRASSESQGLGAGVRTEADVEEEALRRKLEELTSNVSDQETS 374
+E+ S S SS+ + A + L+ K + Q+
Sbjct: 542 EED--------SESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAG 593
Query: 375 SEEEEAKDEKAEPNRDKSVGPLPQADPEVGTA---AHQTNRQEKSPQDPGDPVQYNRTTD 431
+ K EK N + S AD E A A Q K PQ P + N T
Sbjct: 594 PVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTT-- 651
Query: 432 EELSELEDRVAVTASEVQQAESEVSDIESRIAALRAAGLTVKPSGKPRRKSNLPIFLPRV 491
A ++V+ + A R AG P+G P V
Sbjct: 652 -------------------ASAKVAPVRVGTQAPRKAGTATSPAGSS----------PAV 682
Query: 492 AGKLGKRPEDPNADPSSEAK 511
AG + ED ++ S+++
Sbjct: 683 AGGTQRPAEDSSSSEESDSE 702
>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
[Homo sapiens]
Length = 1488
Score = 43.5 bits (101), Expect = 5e-04
Identities = 80/339 (23%), Positives = 132/339 (38%), Gaps = 52/339 (15%)
Query: 155 SEERSGDSDQTDEDGEPG-SEAQAQAQPFGSKKKRLLSVHDFDFEGDSDDSTQPQGHSLH 213
SE+ S SD+TD +G+P AQ +A +K+ + D + Q +G +L
Sbjct: 200 SEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGK-VGDVTPQVKGGAL- 257
Query: 214 LSSVPEARDSPQSLTDESCSEKAAPHKAEGLEEADTGASGCHSHPEEQPTSISPSRHGAL 273
P A+ + + + SE EG E + +G S + + A
Sbjct: 258 ----PPAKRAKKPEEESESSE-------EGSESEEEAPAGTRSQVKASEKILQVRAASAP 306
Query: 274 AELCPPGGSHRMALGTAAALGSNVIRNEQLPLQYLADVDTSDEESIRAHVMASHHSKRRG 333
A+ P G+ G A A+ S + + ++SD E A +K G
Sbjct: 307 AKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASG 366
Query: 334 RAS---------SESQGLGA-----GVRTEADVEEEALRRKLEELTSNVSDQETSSEEEE 379
+ S ES GA G A + +A +R+ D ++SSEE +
Sbjct: 367 KTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKRE--------EDSQSSSEESD 418
Query: 380 AKDEKAEPNRDKSVGPLPQADPEVGTAAHQTNRQEKSPQDPGDPVQYNRTTDEELSELED 439
+++E P + K G PQ A ++ R+ +P P R T ++++
Sbjct: 419 SEEE--APAQAKPSGKAPQV-RAASAPAKESPRKGAAPAPP-------RKTGPAAAQVQ- 467
Query: 440 RVAVTASEVQQAESEVSDIE-SRIAALRAAGLTVKPSGK 477
E ++ SE SD + +AA+ AA VKP GK
Sbjct: 468 --VGKQEEDSRSSSEESDSDREALAAMNAA--QVKPLGK 502
Score = 33.5 bits (75), Expect = 0.54
Identities = 61/301 (20%), Positives = 106/301 (35%), Gaps = 18/301 (5%)
Query: 146 QGGAGPELISEERSGDSDQTDEDGEPGSEAQAQAQPFGSKKKRLLSVHDFDFEGDSDDST 205
Q GPE E SG S++ + D E +E AQ +P G + ++ +
Sbjct: 859 QAQTGPE----EDSGSSEE-ESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAP 913
Query: 206 QPQGHSLHLSSVPEARDSPQSLTDESCSEKAAPHKAEGLEEADTGASGCHSHPEEQPTSI 265
P G + ++ +D S ++ES S+ AP + P P
Sbjct: 914 TPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPL--IFVDPNRSPA-- 969
Query: 266 SPSRHGALAELCPPGGSHRMALGTAAALGSNVIRNEQLPLQ--YLADVDTSDEESIRAHV 323
P+ A A+ R + TA + S + +P + T+ AH
Sbjct: 970 GPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHP 1029
Query: 324 MASHHSKRRGRASS-ESQGLGAGVRTEADVEEEALRR----KLEELTSNVSDQETSSEEE 378
+ + G +SS ES + G + E + + + L + V Q+ S +
Sbjct: 1030 RIAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQP 1089
Query: 379 EAKDEKAEPNRDKSVGPLPQADPEVGTAAHQTNRQEKSPQDPGDPVQYNRTTDEELSELE 438
+ D +VG LP P+ + + + + P+ P VQ E + E
Sbjct: 1090 PVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLP--EVQQATKAPESSDDSE 1147
Query: 439 D 439
D
Sbjct: 1148 D 1148
Score = 33.1 bits (74), Expect = 0.71
Identities = 80/380 (21%), Positives = 127/380 (33%), Gaps = 84/380 (22%)
Query: 147 GGAGPELISEE---RSGDSDQTDEDGEPGSEAQAQAQPFGSKKKRLLSVHDFDFEGDSDD 203
G GP + + R DS + E+ + EA AQA+P G
Sbjct: 392 GKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGK------------------- 432
Query: 204 STQPQGHSLHLSSVPEARDSPQSLTDESCSEKAAPHKAE---GLEEADTGASGCHSHPEE 260
PQ + +S P A++SP+ + K P A+ G +E D+ +S S +
Sbjct: 433 --APQ---VRAASAP-AKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDR 486
Query: 261 QPTSISPSRHGALAELCPPGGSHR------MALGTAAALGSNVIRNEQLPLQYLADVDTS 314
+ + + A++ P G S + M +G V + P A V
Sbjct: 487 EALAAMNA-----AQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKW 541
Query: 315 DEESIRAHVMASHHSKRRGRASSESQGLGAGVRTEADVEEEALRRKLEELTSNVSDQETS 374
+E+ S S SS+ + A + L+ K + Q+
Sbjct: 542 EED--------SESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAG 593
Query: 375 SEEEEAKDEKAEPNRDKSVGPLPQADPEVGTA---AHQTNRQEKSPQDPGDPVQYNRTTD 431
+ K EK N + S AD E A A Q K PQ P + N T
Sbjct: 594 PVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTT-- 651
Query: 432 EELSELEDRVAVTASEVQQAESEVSDIESRIAALRAAGLTVKPSGKPRRKSNLPIFLPRV 491
A ++V+ + A R AG P+G P V
Sbjct: 652 -------------------ASAKVAPVRVGTQAPRKAGTATSPAGSS----------PAV 682
Query: 492 AGKLGKRPEDPNADPSSEAK 511
AG + ED ++ S+++
Sbjct: 683 AGGTQRPAEDSSSSEESDSE 702
>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a
[Homo sapiens]
Length = 1450
Score = 43.5 bits (101), Expect = 5e-04
Identities = 80/339 (23%), Positives = 132/339 (38%), Gaps = 52/339 (15%)
Query: 155 SEERSGDSDQTDEDGEPG-SEAQAQAQPFGSKKKRLLSVHDFDFEGDSDDSTQPQGHSLH 213
SE+ S SD+TD +G+P AQ +A +K+ + D + Q +G +L
Sbjct: 200 SEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGK-VGDVTPQVKGGAL- 257
Query: 214 LSSVPEARDSPQSLTDESCSEKAAPHKAEGLEEADTGASGCHSHPEEQPTSISPSRHGAL 273
P A+ + + + SE EG E + +G S + + A
Sbjct: 258 ----PPAKRAKKPEEESESSE-------EGSESEEEAPAGTRSQVKASEKILQVRAASAP 306
Query: 274 AELCPPGGSHRMALGTAAALGSNVIRNEQLPLQYLADVDTSDEESIRAHVMASHHSKRRG 333
A+ P G+ G A A+ S + + ++SD E A +K G
Sbjct: 307 AKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASG 366
Query: 334 RAS---------SESQGLGA-----GVRTEADVEEEALRRKLEELTSNVSDQETSSEEEE 379
+ S ES GA G A + +A +R+ D ++SSEE +
Sbjct: 367 KTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKRE--------EDSQSSSEESD 418
Query: 380 AKDEKAEPNRDKSVGPLPQADPEVGTAAHQTNRQEKSPQDPGDPVQYNRTTDEELSELED 439
+++E P + K G PQ A ++ R+ +P P R T ++++
Sbjct: 419 SEEE--APAQAKPSGKAPQV-RAASAPAKESPRKGAAPAPP-------RKTGPAAAQVQ- 467
Query: 440 RVAVTASEVQQAESEVSDIE-SRIAALRAAGLTVKPSGK 477
E ++ SE SD + +AA+ AA VKP GK
Sbjct: 468 --VGKQEEDSRSSSEESDSDREALAAMNAA--QVKPLGK 502
Score = 34.7 bits (78), Expect = 0.24
Identities = 64/300 (21%), Positives = 106/300 (35%), Gaps = 54/300 (18%)
Query: 146 QGGAGPELISEERSGDSDQTDEDGEPGSEAQAQAQPFGSKKKRLLSVHDFDFEGDSDDST 205
Q GPE E SG S++ + D E +E AQ +P G
Sbjct: 859 QAQTGPE----EDSGSSEE-ESDSEEEAETLAQVKPSG---------------------- 891
Query: 206 QPQGHSLHLSSVPEARDSPQSLTDESCSEKAAPHKAEGLEEADTGASGCHSHPE-EQPTS 264
+ H + + P A++SP+ + K P A+ ++ D+G+S S + E P +
Sbjct: 892 --KTHQIRAALAP-AKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAA 948
Query: 265 ISPSRHGALAELCPP---GGSHRMALGTAAALGSNVIRNEQLPLQYLADVDTSDEESIRA 321
++ ++ + PP +R G AA P Q A + +
Sbjct: 949 VTSAQ-----VIKPPLIFVDPNRSPAGPAAT-----------PAQAQAASTPRKARASES 992
Query: 322 HVMASHHSKRRGRASSESQGLGAGVRTEADVEEEALRR--KLEELTSNVSDQETSSEEEE 379
+S +Q L G+RT A R + S +E+S +
Sbjct: 993 TARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDG 1052
Query: 380 AKDEKAEPNRDKSVGPLPQADPEVGTAAHQTNRQEKSPQDPGDPVQYNRTTDEELSELED 439
K E D +VG LP P+ + + + + P+ P VQ E + ED
Sbjct: 1053 KKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLP--EVQQATKAPESSDDSED 1110
Score = 33.1 bits (74), Expect = 0.71
Identities = 80/380 (21%), Positives = 127/380 (33%), Gaps = 84/380 (22%)
Query: 147 GGAGPELISEE---RSGDSDQTDEDGEPGSEAQAQAQPFGSKKKRLLSVHDFDFEGDSDD 203
G GP + + R DS + E+ + EA AQA+P G
Sbjct: 392 GKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGK------------------- 432
Query: 204 STQPQGHSLHLSSVPEARDSPQSLTDESCSEKAAPHKAE---GLEEADTGASGCHSHPEE 260
PQ + +S P A++SP+ + K P A+ G +E D+ +S S +
Sbjct: 433 --APQ---VRAASAP-AKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDR 486
Query: 261 QPTSISPSRHGALAELCPPGGSHR------MALGTAAALGSNVIRNEQLPLQYLADVDTS 314
+ + + A++ P G S + M +G V + P A V
Sbjct: 487 EALAAMNA-----AQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKW 541
Query: 315 DEESIRAHVMASHHSKRRGRASSESQGLGAGVRTEADVEEEALRRKLEELTSNVSDQETS 374
+E+ S S SS+ + A + L+ K + Q+
Sbjct: 542 EED--------SESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAG 593
Query: 375 SEEEEAKDEKAEPNRDKSVGPLPQADPEVGTA---AHQTNRQEKSPQDPGDPVQYNRTTD 431
+ K EK N + S AD E A A Q K PQ P + N T
Sbjct: 594 PVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTT-- 651
Query: 432 EELSELEDRVAVTASEVQQAESEVSDIESRIAALRAAGLTVKPSGKPRRKSNLPIFLPRV 491
A ++V+ + A R AG P+G P V
Sbjct: 652 -------------------ASAKVAPVRVGTQAPRKAGTATSPAGSS----------PAV 682
Query: 492 AGKLGKRPEDPNADPSSEAK 511
AG + ED ++ S+++
Sbjct: 683 AGGTQRPAEDSSSSEESDSE 702
>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c
[Homo sapiens]
Length = 958
Score = 43.5 bits (101), Expect = 5e-04
Identities = 80/339 (23%), Positives = 132/339 (38%), Gaps = 52/339 (15%)
Query: 155 SEERSGDSDQTDEDGEPG-SEAQAQAQPFGSKKKRLLSVHDFDFEGDSDDSTQPQGHSLH 213
SE+ S SD+TD +G+P AQ +A +K+ + D + Q +G +L
Sbjct: 200 SEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGK-VGDVTPQVKGGAL- 257
Query: 214 LSSVPEARDSPQSLTDESCSEKAAPHKAEGLEEADTGASGCHSHPEEQPTSISPSRHGAL 273
P A+ + + + SE EG E + +G S + + A
Sbjct: 258 ----PPAKRAKKPEEESESSE-------EGSESEEEAPAGTRSQVKASEKILQVRAASAP 306
Query: 274 AELCPPGGSHRMALGTAAALGSNVIRNEQLPLQYLADVDTSDEESIRAHVMASHHSKRRG 333
A+ P G+ G A A+ S + + ++SD E A +K G
Sbjct: 307 AKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASG 366
Query: 334 RAS---------SESQGLGA-----GVRTEADVEEEALRRKLEELTSNVSDQETSSEEEE 379
+ S ES GA G A + +A +R+ D ++SSEE +
Sbjct: 367 KTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKRE--------EDSQSSSEESD 418
Query: 380 AKDEKAEPNRDKSVGPLPQADPEVGTAAHQTNRQEKSPQDPGDPVQYNRTTDEELSELED 439
+++E P + K G PQ A ++ R+ +P P R T ++++
Sbjct: 419 SEEE--APAQAKPSGKAPQV-RAASAPAKESPRKGAAPAPP-------RKTGPAAAQVQ- 467
Query: 440 RVAVTASEVQQAESEVSDIE-SRIAALRAAGLTVKPSGK 477
E ++ SE SD + +AA+ AA VKP GK
Sbjct: 468 --VGKQEEDSRSSSEESDSDREALAAMNAA--QVKPLGK 502
Score = 33.1 bits (74), Expect = 0.71
Identities = 80/380 (21%), Positives = 127/380 (33%), Gaps = 84/380 (22%)
Query: 147 GGAGPELISEE---RSGDSDQTDEDGEPGSEAQAQAQPFGSKKKRLLSVHDFDFEGDSDD 203
G GP + + R DS + E+ + EA AQA+P G
Sbjct: 392 GKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGK------------------- 432
Query: 204 STQPQGHSLHLSSVPEARDSPQSLTDESCSEKAAPHKAE---GLEEADTGASGCHSHPEE 260
PQ + +S P A++SP+ + K P A+ G +E D+ +S S +
Sbjct: 433 --APQ---VRAASAP-AKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDR 486
Query: 261 QPTSISPSRHGALAELCPPGGSHR------MALGTAAALGSNVIRNEQLPLQYLADVDTS 314
+ + + A++ P G S + M +G V + P A V
Sbjct: 487 EALAAMNA-----AQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKW 541
Query: 315 DEESIRAHVMASHHSKRRGRASSESQGLGAGVRTEADVEEEALRRKLEELTSNVSDQETS 374
+E+ S S SS+ + A + L+ K + Q+
Sbjct: 542 EED--------SESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAG 593
Query: 375 SEEEEAKDEKAEPNRDKSVGPLPQADPEVGTA---AHQTNRQEKSPQDPGDPVQYNRTTD 431
+ K EK N + S AD E A A Q K PQ P + N T
Sbjct: 594 PVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTT-- 651
Query: 432 EELSELEDRVAVTASEVQQAESEVSDIESRIAALRAAGLTVKPSGKPRRKSNLPIFLPRV 491
A ++V+ + A R AG P+G P V
Sbjct: 652 -------------------ASAKVAPVRVGTQAPRKAGTATSPAGSS----------PAV 682
Query: 492 AGKLGKRPEDPNADPSSEAK 511
AG + ED ++ S+++
Sbjct: 683 AGGTQRPAEDSSSSEESDSE 702
>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
Length = 2400
Score = 43.5 bits (101), Expect = 5e-04
Identities = 76/367 (20%), Positives = 131/367 (35%), Gaps = 44/367 (11%)
Query: 146 QGGAGPEL-----ISEERSGDSDQT---DED---GEPGSEAQAQ---AQPFGSKKKRLLS 191
+GG GP L + E G+ Q D+D GE +A AQ + S+
Sbjct: 1727 EGGLGPGLSQGPGVDEGEDGEGSQRLNRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSE 1786
Query: 192 VHDFDFEGDS-----DDSTQPQGHSLHLSSVPEA---RDSPQSLTDESC----SEKAAPH 239
+ + + EG+ + Q GH +L A +D QS E +E A
Sbjct: 1787 LGEAEQEGEGISERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQP 1846
Query: 240 KAEGLEEADTGASGCHSHPEEQPTSISPSRHGALAELCP-------PGGSHRMALGTAAA 292
++EG+E + + E QP S A E P P + + A
Sbjct: 1847 ESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGA 1906
Query: 293 LGSNVIRNEQLPLQYLADVDTSDEESIRAHVMASHHSKRRGRASSESQGLGAGVRTEADV 352
+ Q + + ++T E+ + + ++ + + + V +
Sbjct: 1907 EAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEA 1966
Query: 353 EEEALRRKLEELTSNVSDQETSSEEEEAKDEKAEPNRDKSVGPLPQADPEVGTAAHQTNR 412
EEEA + + E++ + + ET E EA+ E + ++ G + +A+ E +
Sbjct: 1967 EEEA-QPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEA 2025
Query: 413 QEKSPQDPGDPVQYNRTTDE----------ELSELEDRVAVTASEVQQAESEVSDIESRI 462
Q KS + V+ E E E E+ EVQ+AE E +
Sbjct: 2026 QPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDV 2085
Query: 463 AALRAAG 469
A A G
Sbjct: 2086 DAQEAEG 2092
Score = 37.0 bits (84), Expect = 0.049
Identities = 59/307 (19%), Positives = 106/307 (34%), Gaps = 28/307 (9%)
Query: 164 QTDEDGEPGSEAQAQAQPFGSKKKRLLSVHDFDFEGD-------------SDDSTQPQGH 210
Q + +G EA+ +AQP + L + + + E + ++ TQP+
Sbjct: 1900 QPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESE 1959
Query: 211 SLHLSSVPEARDSPQSLTDESCSEKAAPHKAEGL---EEADTGASGCHSHPEEQPTSISP 267
+ S E P+S E+ + +AEG E D A +E P
Sbjct: 1960 VIE-SQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQP 2018
Query: 268 SRHGALAELCPPGGSHRMALGTAAALGSNVIRNEQLPLQYLADVDTSDEESIRAHVMASH 327
G A+ G + G + + P + ++EE+ A
Sbjct: 2019 ESDGVEAQPKSEGEEAQEVEGE-----TQKTEGDAQPESDGVEAPEAEEEAQEAE---GE 2070
Query: 328 HSKRRGRASSESQGLGAGVRTEADVEEEALRRKLEELTSNVSDQETSSEEEEAKDEKAEP 387
+ G A ES+ + A EA+ E + +E + Q+ E + +A+P
Sbjct: 2071 VQEAEGEAHPESEDVDA---QEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQP 2127
Query: 388 NRDKSVGPLPQADPEVGTAAHQTNRQEKSPQDPGDPVQYNRTTDEELSELEDRVAVTASE 447
+ P + + + + + E Q + ++ +E ELE A A
Sbjct: 2128 ESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEG 2187
Query: 448 VQQAESE 454
Q ESE
Sbjct: 2188 EAQPESE 2194
Score = 32.3 bits (72), Expect = 1.2
Identities = 46/217 (21%), Positives = 86/217 (39%), Gaps = 23/217 (10%)
Query: 146 QGGAGPEL--ISEERSGDSDQTDEDGEPGSEAQAQAQPF--GSKKKRLLSVHDFDFEG-- 199
+G A PE I + + + Q + +G EA+ +AQP G + + EG
Sbjct: 2154 EGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVE 2213
Query: 200 --DSDDSTQPQGHSLHLSSVPEARDSPQSLTDESCSEKAAPHKAEGLEEADTGASGCHSH 257
++++ QP+ + E P+S + +K +P + G +++ +
Sbjct: 2214 APEAEEEAQPEPEGVETPEA-EGEAQPESEGETQGEKKGSPQVSLGDGQSEEASESSSPV 2272
Query: 258 PEEQPTSISPSRHGALAELCPPGGSHRMALGTAAALGSNVIRNEQLPLQYLADVDTSDEE 317
PE++PT PS G P GS + A+ N + + L D + D +
Sbjct: 2273 PEDRPTP-PPSPGGDTPHQRP--GSQTGPSSSRASSWGNCWQKDSENDHVLGDTRSPDAK 2329
Query: 318 SIRAHVMASHHSKRRG------RASSESQGLGAGVRT 348
S + H++R+ ++SE + G RT
Sbjct: 2330 S-----TGTPHAERKATRMYPESSTSEQEEAPLGSRT 2361
>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
sapiens]
Length = 699
Score = 43.1 bits (100), Expect = 7e-04
Identities = 81/364 (22%), Positives = 130/364 (35%), Gaps = 63/364 (17%)
Query: 155 SEERSGDSDQTDED--GEPGSEAQAQAQ----PFGSKKKRLLSVHDFDFEGDSDDSTQPQ 208
S S DS + +E+ G P +A A+ P G + + D DD +
Sbjct: 83 SSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQK 142
Query: 209 GHSLHLSSVPEARDSPQSLTDESCSEKAAPHKAEGLEEADTGASGCHSHPEEQPTSISPS 268
+ P+A+ + KA P KA+ ++D+ +S P+ Q I+P
Sbjct: 143 KQPVQKGVKPQAK-----------AAKAPPKKAKS-SDSDSDSSSEDEPPKNQKPKITPV 190
Query: 269 RHGALAELCPPGG--SHRMALGTAAALGSNVIRNEQLPLQYLADVDTSDEESIRAHVMAS 326
A + P + ++A G AA+ S+ + + D S+EE A +
Sbjct: 191 TVKAQTKAPPKPARAAPKIANGKAASSSSSSSSS--------SSSDDSEEEKAAATPKKT 242
Query: 327 HHSKRRGRASSESQGLGAGVRTEADVEEEALRRKLEELTSNVSDQETSSEEEEAKDE-KA 385
K+ V +A V+ + S+ S+ +S EEEE K K
Sbjct: 243 VPKKQ--------------VVAKAPVKAATTPTR----KSSSSEDSSSDEEEEQKKPMKN 284
Query: 386 EPNRDKSVGPLPQADPEVGTAAHQTNRQEKSPQDPGDPVQYNRTTDEELSELEDR----- 440
+P SV P P A P + Q ++ Q P + + + + SE E +
Sbjct: 285 KPGPYSSVPP-PSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKA 343
Query: 441 ----------VAVTASEVQQAESEVSDIESRIAALRAAGLTVKPSGKPRRKSNLPIFLPR 490
A A+E S+ E A + AG T S KP + P P
Sbjct: 344 VVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPA 403
Query: 491 VAGK 494
A K
Sbjct: 404 AAPK 407
Score = 38.9 bits (89), Expect = 0.013
Identities = 62/261 (23%), Positives = 103/261 (39%), Gaps = 39/261 (14%)
Query: 155 SEERSGDSDQT-DEDGEPGSEA---QAQAQPFGSKKKRLLSVHDFDFEGDSDDS--TQPQ 208
SE+ S +SD + +E+ +P ++A +A +P +KK S D + DD ++P
Sbjct: 322 SEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPA 381
Query: 209 GHSLHLSSVPEARDSPQSLTDESCSEK--AAPHKAEGLEEADTGASGCHSHPEEQPTSIS 266
G + + S+ P ++T +S + K AAP + G + S EE+ +S
Sbjct: 382 GTTKNSSNKP-------AVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSE 434
Query: 267 PSRHGALAELCPPGGSHRMALGTAAALGSNVIRNEQLPLQYLADVDTSDEESIRAHVMAS 326
+ + P + + AL A R+ +D D+S E
Sbjct: 435 EEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSS------SDSDSSSSEE-------E 481
Query: 327 HHSKRRGRASSESQGLGAGVRTEADVEEEALRRKLEELTSNVSDQETSSEEEEAKDEKAE 386
+ + Q + G A + A +K + +SN S + SSEEEE K
Sbjct: 482 EEKTSKSAVKKKPQKVAGG----AAPSKPASAKKGKAESSNSSSSDDSSEEEEEK----- 532
Query: 387 PNRDKSVGPLPQADPEVGTAA 407
P PQA GT+A
Sbjct: 533 --LKGKGSPRPQAPKANGTSA 551
Score = 35.8 bits (81), Expect = 0.11
Identities = 106/477 (22%), Positives = 176/477 (36%), Gaps = 111/477 (23%)
Query: 143 GRLQGGAGPELISEERSGDSDQTDEDGEP---GSEAQAQAQPFGSKKKRLLSVHDFDFEG 199
G+ A SEE S D D+ D+ +P G + QA+A KK + D D +
Sbjct: 117 GKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAK---SSDSDSDS 173
Query: 200 DSDDSTQPQGHSLHLSSV----------PEARDSPQ----------------SLTDESCS 233
S+D P+ ++ V AR +P+ S +D+S
Sbjct: 174 SSEDE-PPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEE 232
Query: 234 EKA----------------APHKAEGLEEADTGAS-GCHSHPEEQPTSISPSRHGALAEL 276
EKA AP KA + +S S EE+ ++ G + +
Sbjct: 233 EKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSV 292
Query: 277 CPPGG-SHRMALGTAAALGSNVIRNEQLPLQYLADVDTSDEESIRAHVMASHHSKRRGRA 335
PP + +LGT + +Q P++ + D+SDE +
Sbjct: 293 PPPSAPPPKKSLGTQPP--KKAVEKQQ-PVE--SSEDSSDESD----------------S 331
Query: 336 SSESQGLGAGVRTEADVEEEALR----RKLEELTSNVSDQETSSEEEEAKDEKAEPNRDK 391
SSE + T+A V + + +K E +S+ SD + SSE++EA + A ++
Sbjct: 332 SSEEE---KKPPTKAVVSKATTKPPPAKKAAESSSDSSDSD-SSEDDEAPSKPAGTTKNS 387
Query: 392 SVGP-LPQADPEVGTAAHQTNRQEKSPQDP--GDPVQYNRTTDEELSELEDRVAVTASEV 448
S P + P V AA +P+ P G R D SE E ++SE
Sbjct: 388 SNKPAVTTKSPAVKPAA--------APKQPVGGGQKLLTRKADSSSSEEES----SSSEE 435
Query: 449 QQAESEVSDIESRIAALRAAGLTVKPSGKPRRKSNLPIFLPRVAGKLGKRPEDPNADPSS 508
++ + V+ + + A A L K + + R S+ + E+ S+
Sbjct: 436 EKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSD------SDSSSSEEEEEKTSKSA 489
Query: 509 EAK---------AMAVPYLLRRKFSNSLKSQGKDDDSFDRKSVYRGSLTQRNPNARK 556
K A + P ++ + S S DD S + + +G + R P A K
Sbjct: 490 VKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPR-PQAPK 545
Score = 32.3 bits (72), Expect = 1.2
Identities = 38/160 (23%), Positives = 60/160 (37%), Gaps = 17/160 (10%)
Query: 369 SDQETSSEEEEAKDEKAEPNRDKSVGPLPQADPEVGTAAHQTNRQEKSPQDPGDPVQYNR 428
SD E SSEEEE E P K+ P + G AA + + S + D + ++
Sbjct: 85 SDSEDSSEEEE---EVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQ 141
Query: 429 TTDEELSELEDRVAVTASEVQQAESEVSDIES------------RIAALRAAGLTVKPSG 476
++ + + ++A+S SD +S +I + T P
Sbjct: 142 KKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPP- 200
Query: 477 KPRRKSNLPIFLPRVAGKLGKRPEDPNADPSSEAKAMAVP 516
KP R + I + A ++D S E KA A P
Sbjct: 201 KPARAAP-KIANGKAASSSSSSSSSSSSDDSEEEKAAATP 239
>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
Length = 2752
Score = 43.1 bits (100), Expect = 7e-04
Identities = 77/364 (21%), Positives = 126/364 (34%), Gaps = 52/364 (14%)
Query: 158 RSGDSDQTDEDGEPGSEAQAQAQPFGSKKKRLLSVHDFDFEGDSDDSTQPQGHSL-HLSS 216
R+ +++ P ++ Q A P S+ + L+ V + S +P G L HLSS
Sbjct: 1207 RTPPRERSGAGSSPETKEQNSALPTSSQDEELMEV--------VEKSEEPAGQILSHLSS 1258
Query: 217 V------------PEARDSPQSLTDESCSEKAAPHKAEGLEEADTGASGCHSHPEEQPTS 264
PE + P S+ A +A + + G H PE + S
Sbjct: 1259 ELKEMSTSNFESSPEVEERPAVSLTLDQSQSQASLEAVEVPSMASSWGGPHFSPEHKELS 1318
Query: 265 ISPSRHGALAELCPPGGSHRMALGTAAALGSNVIRNEQLPLQYLADVDTS-----DEESI 319
SP R + P + LGT G + E L +L ++T E+S
Sbjct: 1319 NSPLRENSFGS--PLEFRNSGPLGTEMNTGFSSEVKEDLNGPFLNQLETDPSLDMKEQST 1376
Query: 320 RAHVMASHHSKRRGRASSESQGLGAGVRTEADVEEEALRRKLEELTSNVSDQE------- 372
R+ + H S + E G+ + + V + R E +S+ S E
Sbjct: 1377 RS---SGHSSSELSPDAVEKAGMSSNQSISSPVLDAVPRTPSRERSSSASSPEMKDGLPR 1433
Query: 373 ------TSSEEEEAKDEKAEPNRDKSVGPLPQADPEVGTAAHQTNRQEKSPQDPGDP-VQ 425
S +D P+R G P T + + + SP+ P
Sbjct: 1434 TPSRRSRSGSSPGLRDGSGTPSRHSLSGSSPGMKDIPRTPSRGRSECDSSPEPKALPQTP 1493
Query: 426 YNRTTDEELSELEDRVAVTASEVQQAESEV-------SDIESRIAALRAAGLTVKPSGKP 478
R+ EL ++ E +ES V + + R + + L VKPS P
Sbjct: 1494 RPRSRSPSSPELNNKCLTPQRERSGSESSVDQKTVARTPLGQRSRSGSSQELDVKPSASP 1553
Query: 479 RRKS 482
+ +S
Sbjct: 1554 QERS 1557
Score = 33.9 bits (76), Expect = 0.41
Identities = 81/398 (20%), Positives = 137/398 (34%), Gaps = 84/398 (21%)
Query: 134 SAKVIRSLHGRLQGGAGPELISEERSGDSDQTDEDGEPGSEAQAQAQPFGSKKKRLLSVH 193
S +V S + R+ G P L+ RS +T S ++ P S +
Sbjct: 2382 SPRVPLSAYERVSGRTSPPLLDRARS----RTPPSAPSQSRMTSERAPSPSSR------- 2430
Query: 194 DFDFEGDSDDSTQPQGHSLHLSSVPEARDSPQS-----LTDESCSEKAAPHKAEGLEEAD 248
G + S +P A+D P+S +D+S A G +
Sbjct: 2431 --------------MGQAPSQSLLPPAQDQPRSPVPSAFSDQSRCLIAQTTPVAGSQSLS 2476
Query: 249 TGASGCHSHPEEQPTSISPSRHGALAELCPPGGSH----RMALGTAAALGSNVIRNEQLP 304
+GA T+ S H + + PG H T A S + +
Sbjct: 2477 SGAVAT--------TTSSAGDHNGMLSVPAPGVPHSDVGEPPASTGAQQPSALAALQPAK 2528
Query: 305 LQYLADVDTSDEESIRAHVMASHHSKRRGRASSESQGLGAGVRTEADVE---------EE 355
+ + +S S + +S S G +SS+S+G V+ E ++ +E
Sbjct: 2529 ERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPTPAPKE 2588
Query: 356 ALR-----------RKLEELTSNVSDQETSSEEEEAKDEKAEPNRDKSVG---------- 394
A+R RK +S+ S +SS + + + S
Sbjct: 2589 AVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2648
Query: 395 -----PLPQADPEVGTAAHQT--NRQEKSPQDPGDPVQYNRTTDEELSELEDRVAVTASE 447
P PQA P+ + R+ +SP+ P D ++ +R+ S +E R
Sbjct: 2649 PSPAKPGPQALPKPASPKKPPPGERRSRSPRKPIDSLRDSRSL--SYSPVERRRPSPQPS 2706
Query: 448 VQQAESEVSDIESRIAALRAAGLTVKPSGKPRRKSNLP 485
+ +S S+ SR G + PS K RR++ P
Sbjct: 2707 PRDQQSSSSERGSRRG---QRGDSRSPSHKRRRETPSP 2741
Score = 31.6 bits (70), Expect = 2.1
Identities = 78/383 (20%), Positives = 132/383 (34%), Gaps = 30/383 (7%)
Query: 149 AGPELISEERSGDSDQTDEDGEPGSEAQAQAQPFGSKKKRLLSVHDFDFEGDSDDSTQPQ 208
+GP L +E +G S + ED Q + P K++ S D+ +
Sbjct: 1336 SGP-LGTEMNTGFSSEVKEDLNGPFLNQLETDPSLDMKEQSTRSSGHSSSELSPDAVEKA 1394
Query: 209 GHSLHLS-SVPEARDSPQSLTDESCSEKAAPHKAEGLEEADTGASGCHSHPEEQPTSISP 267
G S + S S P P++ + E S ++P +GL + S S P + S +P
Sbjct: 1395 GMSSNQSISSPVLDAVPRTPSRERSSSASSPEMKDGLPRTPSRRSRSGSSPGLRDGSGTP 1454
Query: 268 SRHGALAELCPPGGSHRMALGTAAALGSNVIRNEQLPLQYLADVDTSDEESIRAHVMASH 327
SRH + ++ G I + P + ++ D+S E + +
Sbjct: 1455 SRHSL----------------SGSSPGMKDI--PRTPSRGRSECDSSPEPKA---LPQTP 1493
Query: 328 HSKRRGRASSESQGLGAGVRTEADVEEEALRRKLEELTSNVSDQETSSEEEEAKDEKAEP 387
+ R +S E + E E ++ +K T + S +E A P
Sbjct: 1494 RPRSRSPSSPELNNKCLTPQRERSGSESSVDQKTVARTPLGQRSRSGSSQELDVKPSASP 1553
Query: 388 NRDKSVGPLPQADPEVGTAAHQTNRQEKSPQ-DPGDPVQYNRTTDEELSELED--RVAVT 444
P + + T Q +R SP+ D + R+ E++D R A
Sbjct: 1554 QERSESDSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSPRRSRSGSSPEVKDKPRAAPR 1613
Query: 445 ASEVQQAESEVSDIESRIAALRA-AGLTVKPSGKPRRKSNLPIFLPRVAGKLGKRPEDPN 503
A + E R R+ +G + K G S+ P K
Sbjct: 1614 AQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRGPSPEGSSSTESSPEHPPKSRTARRGSR 1673
Query: 504 ADPSSEAKAMAVPYLLRRKFSNS 526
+ P + K+ P RR+ S S
Sbjct: 1674 SSPEPKTKSRTPP---RRRSSRS 1693
>gi|66792814 retrotransposon gag domain containing 4 [Homo sapiens]
Length = 569
Score = 42.7 bits (99), Expect = 9e-04
Identities = 48/210 (22%), Positives = 83/210 (39%), Gaps = 42/210 (20%)
Query: 315 DEESIRAHVMASHHSKRRGRA----SSESQGLGAGVRTEADVEEEALRRKLEELTSNVSD 370
+++ R H + S ++R RA E + E +EE + EE+ +
Sbjct: 348 EDQEARRHRLHSKDQRKRMRAFQQEMKEKEEEEMKKEEEMKKKEEKEEEEEEEMKQKEEE 407
Query: 371 QETSSEEEEAKDEKAEPNRDKSVGPLPQADPEVGTAAHQTNRQEKSPQDPGDPVQYNRTT 430
+E ++ EE + K E + D+ G P+ +P+ QDPG Y
Sbjct: 408 EEIRNKNEEEGESKDEEDEDEDGGQKPEGEPQ---------------QDPGTEETYGEVE 452
Query: 431 DEELSELEDRVAVTASEVQ----QAESEVSDIESRIAA---LRAAGLTVKPSGKPRRKSN 483
+E L E +D E++ A S+ S S A L A+ ++PS + R ++
Sbjct: 453 EEPLDEAQDDDLDELMEMEPTFVHASSQTSGPTSGYHAENFLGASPPIIQPS-RRRNQNR 511
Query: 484 LPIF---------------LPRVAGKLGKR 498
+P+ L R G+LG+R
Sbjct: 512 VPLLEGLPGTNSPFYSSPQLIRRTGRLGQR 541
>gi|27262628 nuclear autoantigenic sperm protein isoform 2 [Homo
sapiens]
Length = 788
Score = 42.4 bits (98), Expect = 0.001
Identities = 70/329 (21%), Positives = 130/329 (39%), Gaps = 62/329 (18%)
Query: 146 QGGAGPELISEER--SGDSDQTDEDGEP-----GSEAQAQAQPFGSKKKR---LLSVHDF 195
+GGA PE +E SG +Q D E G++ Q + + G ++K+ ++S+ +
Sbjct: 214 KGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEK 273
Query: 196 DFEGDSDD---STQPQGHSLHLSS---------VPEARDSPQS--LTDESCSEKAAPHKA 241
E + + + QG ++ + + V D P+ +T E+ + KA +
Sbjct: 274 PKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQL 333
Query: 242 EGLEEADTGASGCHSHPEEQPTSISPSRHGALAELCPPGGSHRMALGTAAALGSNVIRNE 301
G E S PE + S A +E+ G L A+ + +
Sbjct: 334 VGQEVPPAEES-----PEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGD 388
Query: 302 QLPLQYLADVD----TSD----EESIRAHVMASHHSKRRGRASSESQGLGAGVRTEADVE 353
Q P++ ++ T D EE +RA ++ S + + ES+ G GV T+ V
Sbjct: 389 QTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKL--SVEESEAAGDGVDTK--VA 444
Query: 354 EEALRRKLEELTSNVSDQETSSEEEEAKDEKAEPNRDKSVGPLPQADPEVGTAAHQTNRQ 413
+ A + E+ +++ET EE+ K+ + E +
Sbjct: 445 QGATEKSPEDKVQIAANEETQEREEQMKEGE-----------------ETEGSEEDDKEN 487
Query: 414 EKSPQDPGDPVQYNRT----TDEELSELE 438
+K+ + P D V N++ +EE+ LE
Sbjct: 488 DKTEEMPNDSVLENKSLQENEEEEIGNLE 516
>gi|27262634 nuclear autoantigenic sperm protein isoform 1 [Homo
sapiens]
Length = 790
Score = 42.4 bits (98), Expect = 0.001
Identities = 70/329 (21%), Positives = 130/329 (39%), Gaps = 62/329 (18%)
Query: 146 QGGAGPELISEER--SGDSDQTDEDGEP-----GSEAQAQAQPFGSKKKR---LLSVHDF 195
+GGA PE +E SG +Q D E G++ Q + + G ++K+ ++S+ +
Sbjct: 216 KGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEK 275
Query: 196 DFEGDSDD---STQPQGHSLHLSS---------VPEARDSPQS--LTDESCSEKAAPHKA 241
E + + + QG ++ + + V D P+ +T E+ + KA +
Sbjct: 276 PKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQL 335
Query: 242 EGLEEADTGASGCHSHPEEQPTSISPSRHGALAELCPPGGSHRMALGTAAALGSNVIRNE 301
G E S PE + S A +E+ G L A+ + +
Sbjct: 336 VGQEVPPAEES-----PEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGD 390
Query: 302 QLPLQYLADVD----TSD----EESIRAHVMASHHSKRRGRASSESQGLGAGVRTEADVE 353
Q P++ ++ T D EE +RA ++ S + + ES+ G GV T+ V
Sbjct: 391 QTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKL--SVEESEAAGDGVDTK--VA 446
Query: 354 EEALRRKLEELTSNVSDQETSSEEEEAKDEKAEPNRDKSVGPLPQADPEVGTAAHQTNRQ 413
+ A + E+ +++ET EE+ K+ + E +
Sbjct: 447 QGATEKSPEDKVQIAANEETQEREEQMKEGE-----------------ETEGSEEDDKEN 489
Query: 414 EKSPQDPGDPVQYNRT----TDEELSELE 438
+K+ + P D V N++ +EE+ LE
Sbjct: 490 DKTEEMPNDSVLENKSLQENEEEEIGNLE 518
>gi|48255931 hepatoma-derived growth factor-related protein 2
isoform 1 [Homo sapiens]
Length = 671
Score = 42.4 bits (98), Expect = 0.001
Identities = 66/310 (21%), Positives = 119/310 (38%), Gaps = 39/310 (12%)
Query: 155 SEERSGDSDQT-DEDGEPGSEAQAQAQ---PFGS-KKKRLLSVHDFDFEGDSDDSTQPQG 209
+ E S +S++T D+D P +A +A P G KKK+ S D D + DS D +P+
Sbjct: 189 NSESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADS-DGAKPEP 247
Query: 210 HSLHLSSVPEARDSPQSLTDESCSEKAAPHKAEGLEEADTGASGCHSHPEEQPTSISPSR 269
++ S+ + S S +D S K P + E+ G PE P+S S
Sbjct: 248 VAMARSA--SSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSSDS 305
Query: 270 HGALAELCPPGGSHRMALGTAAALGSNVIRNEQLPLQYLADVDTSDEESIRAHVMASHHS 329
E+ R L + R ++ L+ L + + ++E R
Sbjct: 306 DS--DEVDRISEWKRRDEARRRELEARRRREQEEELRRLREQEKEEKERRRERADRGEAE 363
Query: 330 KRRGRASSES-------------QGLGAGVRTEADVEEEALRRKLEELTSNVSDQETSSE 376
+ G +S + +G G G + +D E EA +LE + + SS
Sbjct: 364 RGSGGSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEPEA---ELEREAKKSAKKPQSSS 420
Query: 377 EEEA-----KDEKAEPNRDKSVGPLPQADPEVGTAAHQTNRQEKSPQDPGDPVQYNRTTD 431
E A K+++ P + P+ + +R+ + ++P + +
Sbjct: 421 TEPARKPGQKEKRVRPEEKQQAKPVKVERTRKRSEGFSMDRKVEKKKEP--------SVE 472
Query: 432 EELSELEDRV 441
E+L +L +
Sbjct: 473 EKLQKLHSEI 482
Score = 31.6 bits (70), Expect = 2.1
Identities = 17/62 (27%), Positives = 33/62 (53%)
Query: 334 RASSESQGLGAGVRTEADVEEEALRRKLEELTSNVSDQETSSEEEEAKDEKAEPNRDKSV 393
+ +E + G + E +E+A + +L++ V+ + TS + E A+D++ E RD
Sbjct: 568 KEKAEEKLAGEELAGEEAPQEKAEDKPSTDLSAPVNGEATSQKGESAEDKEHEEGRDSEE 627
Query: 394 GP 395
GP
Sbjct: 628 GP 629
>gi|14249158 hepatoma-derived growth factor-related protein 2
isoform 2 [Homo sapiens]
Length = 670
Score = 42.4 bits (98), Expect = 0.001
Identities = 66/310 (21%), Positives = 119/310 (38%), Gaps = 39/310 (12%)
Query: 155 SEERSGDSDQT-DEDGEPGSEAQAQAQ---PFGS-KKKRLLSVHDFDFEGDSDDSTQPQG 209
+ E S +S++T D+D P +A +A P G KKK+ S D D + DS D +P+
Sbjct: 189 NSESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADS-DGAKPEP 247
Query: 210 HSLHLSSVPEARDSPQSLTDESCSEKAAPHKAEGLEEADTGASGCHSHPEEQPTSISPSR 269
++ S+ + S S +D S K P + E+ G PE P+S S
Sbjct: 248 VAMARSA--SSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSSDS 305
Query: 270 HGALAELCPPGGSHRMALGTAAALGSNVIRNEQLPLQYLADVDTSDEESIRAHVMASHHS 329
E+ R L + R ++ L+ L + + ++E R
Sbjct: 306 DS--DEVDRISEWKRRDEARRRELEARRRREQEEELRRLREQEKEEKERRRERADRGEAE 363
Query: 330 KRRGRASSES-------------QGLGAGVRTEADVEEEALRRKLEELTSNVSDQETSSE 376
+ G +S + +G G G + +D E EA +LE + + SS
Sbjct: 364 RGSGGSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEPEA---ELEREAKKSAKKPQSSS 420
Query: 377 EEEA-----KDEKAEPNRDKSVGPLPQADPEVGTAAHQTNRQEKSPQDPGDPVQYNRTTD 431
E A K+++ P + P+ + +R+ + ++P + +
Sbjct: 421 TEPARKPGQKEKRVRPEEKQQAKPVKVERTRKRSEGFSMDRKVEKKKEP--------SVE 472
Query: 432 EELSELEDRV 441
E+L +L +
Sbjct: 473 EKLQKLHSEI 482
Score = 31.6 bits (70), Expect = 2.1
Identities = 17/62 (27%), Positives = 33/62 (53%)
Query: 334 RASSESQGLGAGVRTEADVEEEALRRKLEELTSNVSDQETSSEEEEAKDEKAEPNRDKSV 393
+ +E + G + E +E+A + +L++ V+ + TS + E A+D++ E RD
Sbjct: 568 KEKAEEKLAGEELAGEEAPQEKAEDKPSTDLSAPVNGEATSQKGESAEDKEHEEGRDSEE 627
Query: 394 GP 395
GP
Sbjct: 628 GP 629
>gi|217330641 IWS1 homolog [Homo sapiens]
Length = 819
Score = 42.0 bits (97), Expect = 0.002
Identities = 76/335 (22%), Positives = 130/335 (38%), Gaps = 43/335 (12%)
Query: 155 SEERSGDSDQTDEDGEPGSEAQAQAQPFGSKKKRLLSVHDFDFEGDSDDSTQPQGHSLHL 214
S+ + D +Q D E SE + S+ + LL+ H D E + H
Sbjct: 106 SDSENEDVNQHGSDSE--SEETRKLPGSDSENEELLNGHASDSENEDVGK-----HPASD 158
Query: 215 SSVPEARDSPQSLTD----------ESCSEKAAPHKAEGLE-EADTGASGCHSHPEEQPT 263
S + E + SP S ++ +S SE+ H+A E E S EE P
Sbjct: 159 SEIEELQKSPASDSETEDALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPK 218
Query: 264 -------SISPSRHGAL----AELCPPGGSHRMALGTAAALGSNVIRNEQLPLQYLADVD 312
S P RH A EL P S + S+ NE+LP ++D +
Sbjct: 219 PQVSDSESEEPPRHQASDSENEELPKPRISDSESEDPPRHQASDS-ENEELPKPRISDSE 277
Query: 313 TSDEESIRAHVMASHHSKRRGRASSESQGLGAGVRTEADVEEEALRRKLEELTSNVSDQE 372
+ D +A + + + SES+G G ++++ E+A R K + + + SD+E
Sbjct: 278 SEDPPRNQASDSENEELPKPRVSDSESEGPQKGPASDSET-EDASRHKQKPESDDDSDRE 336
Query: 373 TSSEEEEAKDEKAEPNRDKSVGPLPQADPEVGTAAHQTNRQEKSPQD----PGDPVQYNR 428
E+ E +++ + +D E + ++++K D G+ + +
Sbjct: 337 NKGEDTEMQNDSFHSDSHMDRKKFHSSDSE-----EEEHKKQKMDSDEDEKEGEEEKVAK 391
Query: 429 TTDEELSELEDRVAVTASE---VQQAESEVSDIES 460
LS+ ED +A + V A+ SD S
Sbjct: 392 RKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVS 426
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.127 0.358
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,890,210
Number of Sequences: 37866
Number of extensions: 1233587
Number of successful extensions: 9173
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 102
Number of HSP's successfully gapped in prelim test: 463
Number of HSP's that attempted gapping in prelim test: 7566
Number of HSP's gapped (non-prelim): 1716
length of query: 572
length of database: 18,247,518
effective HSP length: 108
effective length of query: 464
effective length of database: 14,157,990
effective search space: 6569307360
effective search space used: 6569307360
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.