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Search of human proteins with 15011974
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|15011974 Rho/Rac guanine nucleotide exchange factor 2
isooform 3 [Homo sapiens]
(958 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|253735778 Rho/Rac guanine nucleotide exchange factor 2 isofor... 1884 0.0
gi|15011974 Rho/Rac guanine nucleotide exchange factor 2 isoofor... 1884 0.0
gi|253735775 Rho/Rac guanine nucleotide exchange factor 2 isofor... 1880 0.0
gi|31563330 A-kinase anchor protein 13 isoform 1 [Homo sapiens] 574 e-163
gi|21493031 A-kinase anchor protein 13 isoform 3 [Homo sapiens] 574 e-163
gi|21493029 A-kinase anchor protein 13 isoform 2 [Homo sapiens] 574 e-163
gi|122937434 Rho-guanine nucleotide exchange factor [Homo sapiens] 509 e-144
gi|195972857 Rho/Rac guanine nucleotide exchange factor 18 isofo... 467 e-131
gi|41327769 Rho/Rac guanine nucleotide exchange factor 18 isofor... 466 e-131
gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isof... 185 2e-46
gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isofo... 185 2e-46
gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo... 171 3e-42
gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1 [... 168 3e-41
gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3 [... 168 3e-41
gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2 [... 168 3e-41
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 88 4e-17
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 88 4e-17
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 81 4e-15
gi|134133248 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens] 77 8e-14
gi|134133265 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens] 77 8e-14
gi|163792208 Rho guanine exchange factor 16 [Homo sapiens] 73 1e-12
gi|38373682 pleckstrin homology domain containing family G membe... 73 1e-12
gi|111154084 pleckstrin homology domain containing family G memb... 73 1e-12
gi|111154088 pleckstrin homology domain containing family G memb... 73 1e-12
gi|111154080 pleckstrin homology domain containing family G memb... 73 1e-12
gi|111154078 pleckstrin homology domain containing family G memb... 73 1e-12
gi|222080070 pleckstrin homology domain-containing family G memb... 72 3e-12
gi|222080068 pleckstrin homology domain-containing family G memb... 72 3e-12
gi|222080066 pleckstrin homology domain-containing family G memb... 72 3e-12
gi|190885497 Rho guanine nucleotide exchange factor 3 isoform 2 ... 69 2e-11
>gi|253735778 Rho/Rac guanine nucleotide exchange factor 2 isoform 2
[Homo sapiens]
Length = 985
Score = 1884 bits (4881), Expect = 0.0
Identities = 958/958 (100%), Positives = 958/958 (100%)
Query: 1 MKEAKDARYTNGHLFTTISVSGMTMCYACNKSITAKEALICPTCNVTIHNRCKDTLANCT 60
MKEAKDARYTNGHLFTTISVSGMTMCYACNKSITAKEALICPTCNVTIHNRCKDTLANCT
Sbjct: 28 MKEAKDARYTNGHLFTTISVSGMTMCYACNKSITAKEALICPTCNVTIHNRCKDTLANCT 87
Query: 61 KVKQKQQKAALLKNNTALQSVSLRSKTTIRERPSSAIYPSDSFRQSLLGSRRGRSSLSLA 120
KVKQKQQKAALLKNNTALQSVSLRSKTTIRERPSSAIYPSDSFRQSLLGSRRGRSSLSLA
Sbjct: 88 KVKQKQQKAALLKNNTALQSVSLRSKTTIRERPSSAIYPSDSFRQSLLGSRRGRSSLSLA 147
Query: 121 KSVSTTNIAGHFNDESPLGLRRILSQSTDSLNMRNRTLSVESLIDEEVIYSELMSDFEMD 180
KSVSTTNIAGHFNDESPLGLRRILSQSTDSLNMRNRTLSVESLIDEEVIYSELMSDFEMD
Sbjct: 148 KSVSTTNIAGHFNDESPLGLRRILSQSTDSLNMRNRTLSVESLIDEEVIYSELMSDFEMD 207
Query: 181 EKDFAADSWSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEE 240
EKDFAADSWSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEE
Sbjct: 208 EKDFAADSWSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEE 267
Query: 241 LHLEPGVVQGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLISQFSG 300
LHLEPGVVQGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLISQFSG
Sbjct: 268 LHLEPGVVQGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLISQFSG 327
Query: 301 PSAEQMCKTYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQECILLVT 360
PSAEQMCKTYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQECILLVT
Sbjct: 328 PSAEQMCKTYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQECILLVT 387
Query: 361 QRITKYPLLISRILQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQEIYNR 420
QRITKYPLLISRILQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQEIYNR
Sbjct: 388 QRITKYPLLISRILQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQEIYNR 447
Query: 421 MDPRAQTPVPGKGPFGREELLRRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVFLQEKDQ 480
MDPRAQTPVPGKGPFGREELLRRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVFLQEKDQ
Sbjct: 448 MDPRAQTPVPGKGPFGREELLRRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVFLQEKDQ 507
Query: 481 KYIFPTLDKPSVVSLQNLIVRDIANQEKGMFLISAAPPEMYEVHTASRDDRSTWIRVIQQ 540
KYIFPTLDKPSVVSLQNLIVRDIANQEKGMFLISAAPPEMYEVHTASRDDRSTWIRVIQQ
Sbjct: 508 KYIFPTLDKPSVVSLQNLIVRDIANQEKGMFLISAAPPEMYEVHTASRDDRSTWIRVIQQ 567
Query: 541 SVRTCPSREDFPLIETEDEAYLRRIKMELQQKDRALVELLREKVGLFAEMTHFQAEEDGG 600
SVRTCPSREDFPLIETEDEAYLRRIKMELQQKDRALVELLREKVGLFAEMTHFQAEEDGG
Sbjct: 568 SVRTCPSREDFPLIETEDEAYLRRIKMELQQKDRALVELLREKVGLFAEMTHFQAEEDGG 627
Query: 601 SGMALPTLPRGLFRSESLESPRGERLLQDAIREVEGLKDLLVGPGVELLLTPREPALPLE 660
SGMALPTLPRGLFRSESLESPRGERLLQDAIREVEGLKDLLVGPGVELLLTPREPALPLE
Sbjct: 628 SGMALPTLPRGLFRSESLESPRGERLLQDAIREVEGLKDLLVGPGVELLLTPREPALPLE 687
Query: 661 PDSGGNTSPGVTANGEARTFNGSIELCRADSDSSQRDRNGNQLRSPQEEALQRLVNLYGL 720
PDSGGNTSPGVTANGEARTFNGSIELCRADSDSSQRDRNGNQLRSPQEEALQRLVNLYGL
Sbjct: 688 PDSGGNTSPGVTANGEARTFNGSIELCRADSDSSQRDRNGNQLRSPQEEALQRLVNLYGL 747
Query: 721 LHGLQAAVAQQDTLMEARFPEGPERREKLCRANSRDGEAGRAGAAPVAPEKQATELALLQ 780
LHGLQAAVAQQDTLMEARFPEGPERREKLCRANSRDGEAGRAGAAPVAPEKQATELALLQ
Sbjct: 748 LHGLQAAVAQQDTLMEARFPEGPERREKLCRANSRDGEAGRAGAAPVAPEKQATELALLQ 807
Query: 781 RQHALLQEELRRCRRLGEERATEAGSLEARLRESEQARALLEREAEEARRQLAALGQTEP 840
RQHALLQEELRRCRRLGEERATEAGSLEARLRESEQARALLEREAEEARRQLAALGQTEP
Sbjct: 808 RQHALLQEELRRCRRLGEERATEAGSLEARLRESEQARALLEREAEEARRQLAALGQTEP 867
Query: 841 LPAEAPWARRPVDPRRRSLPAGDALYLSFNPPQPSRGTDRLDLPVTTRSVHRNFEDRERQ 900
LPAEAPWARRPVDPRRRSLPAGDALYLSFNPPQPSRGTDRLDLPVTTRSVHRNFEDRERQ
Sbjct: 868 LPAEAPWARRPVDPRRRSLPAGDALYLSFNPPQPSRGTDRLDLPVTTRSVHRNFEDRERQ 927
Query: 901 ELGSPEERLQDSSDPDTGSEEEGSSRLSPPHSPRDFTRMQDIPEETESRDGEAVASES 958
ELGSPEERLQDSSDPDTGSEEEGSSRLSPPHSPRDFTRMQDIPEETESRDGEAVASES
Sbjct: 928 ELGSPEERLQDSSDPDTGSEEEGSSRLSPPHSPRDFTRMQDIPEETESRDGEAVASES 985
>gi|15011974 Rho/Rac guanine nucleotide exchange factor 2 isooform 3
[Homo sapiens]
Length = 958
Score = 1884 bits (4881), Expect = 0.0
Identities = 958/958 (100%), Positives = 958/958 (100%)
Query: 1 MKEAKDARYTNGHLFTTISVSGMTMCYACNKSITAKEALICPTCNVTIHNRCKDTLANCT 60
MKEAKDARYTNGHLFTTISVSGMTMCYACNKSITAKEALICPTCNVTIHNRCKDTLANCT
Sbjct: 1 MKEAKDARYTNGHLFTTISVSGMTMCYACNKSITAKEALICPTCNVTIHNRCKDTLANCT 60
Query: 61 KVKQKQQKAALLKNNTALQSVSLRSKTTIRERPSSAIYPSDSFRQSLLGSRRGRSSLSLA 120
KVKQKQQKAALLKNNTALQSVSLRSKTTIRERPSSAIYPSDSFRQSLLGSRRGRSSLSLA
Sbjct: 61 KVKQKQQKAALLKNNTALQSVSLRSKTTIRERPSSAIYPSDSFRQSLLGSRRGRSSLSLA 120
Query: 121 KSVSTTNIAGHFNDESPLGLRRILSQSTDSLNMRNRTLSVESLIDEEVIYSELMSDFEMD 180
KSVSTTNIAGHFNDESPLGLRRILSQSTDSLNMRNRTLSVESLIDEEVIYSELMSDFEMD
Sbjct: 121 KSVSTTNIAGHFNDESPLGLRRILSQSTDSLNMRNRTLSVESLIDEEVIYSELMSDFEMD 180
Query: 181 EKDFAADSWSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEE 240
EKDFAADSWSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEE
Sbjct: 181 EKDFAADSWSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEE 240
Query: 241 LHLEPGVVQGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLISQFSG 300
LHLEPGVVQGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLISQFSG
Sbjct: 241 LHLEPGVVQGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLISQFSG 300
Query: 301 PSAEQMCKTYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQECILLVT 360
PSAEQMCKTYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQECILLVT
Sbjct: 301 PSAEQMCKTYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQECILLVT 360
Query: 361 QRITKYPLLISRILQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQEIYNR 420
QRITKYPLLISRILQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQEIYNR
Sbjct: 361 QRITKYPLLISRILQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQEIYNR 420
Query: 421 MDPRAQTPVPGKGPFGREELLRRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVFLQEKDQ 480
MDPRAQTPVPGKGPFGREELLRRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVFLQEKDQ
Sbjct: 421 MDPRAQTPVPGKGPFGREELLRRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVFLQEKDQ 480
Query: 481 KYIFPTLDKPSVVSLQNLIVRDIANQEKGMFLISAAPPEMYEVHTASRDDRSTWIRVIQQ 540
KYIFPTLDKPSVVSLQNLIVRDIANQEKGMFLISAAPPEMYEVHTASRDDRSTWIRVIQQ
Sbjct: 481 KYIFPTLDKPSVVSLQNLIVRDIANQEKGMFLISAAPPEMYEVHTASRDDRSTWIRVIQQ 540
Query: 541 SVRTCPSREDFPLIETEDEAYLRRIKMELQQKDRALVELLREKVGLFAEMTHFQAEEDGG 600
SVRTCPSREDFPLIETEDEAYLRRIKMELQQKDRALVELLREKVGLFAEMTHFQAEEDGG
Sbjct: 541 SVRTCPSREDFPLIETEDEAYLRRIKMELQQKDRALVELLREKVGLFAEMTHFQAEEDGG 600
Query: 601 SGMALPTLPRGLFRSESLESPRGERLLQDAIREVEGLKDLLVGPGVELLLTPREPALPLE 660
SGMALPTLPRGLFRSESLESPRGERLLQDAIREVEGLKDLLVGPGVELLLTPREPALPLE
Sbjct: 601 SGMALPTLPRGLFRSESLESPRGERLLQDAIREVEGLKDLLVGPGVELLLTPREPALPLE 660
Query: 661 PDSGGNTSPGVTANGEARTFNGSIELCRADSDSSQRDRNGNQLRSPQEEALQRLVNLYGL 720
PDSGGNTSPGVTANGEARTFNGSIELCRADSDSSQRDRNGNQLRSPQEEALQRLVNLYGL
Sbjct: 661 PDSGGNTSPGVTANGEARTFNGSIELCRADSDSSQRDRNGNQLRSPQEEALQRLVNLYGL 720
Query: 721 LHGLQAAVAQQDTLMEARFPEGPERREKLCRANSRDGEAGRAGAAPVAPEKQATELALLQ 780
LHGLQAAVAQQDTLMEARFPEGPERREKLCRANSRDGEAGRAGAAPVAPEKQATELALLQ
Sbjct: 721 LHGLQAAVAQQDTLMEARFPEGPERREKLCRANSRDGEAGRAGAAPVAPEKQATELALLQ 780
Query: 781 RQHALLQEELRRCRRLGEERATEAGSLEARLRESEQARALLEREAEEARRQLAALGQTEP 840
RQHALLQEELRRCRRLGEERATEAGSLEARLRESEQARALLEREAEEARRQLAALGQTEP
Sbjct: 781 RQHALLQEELRRCRRLGEERATEAGSLEARLRESEQARALLEREAEEARRQLAALGQTEP 840
Query: 841 LPAEAPWARRPVDPRRRSLPAGDALYLSFNPPQPSRGTDRLDLPVTTRSVHRNFEDRERQ 900
LPAEAPWARRPVDPRRRSLPAGDALYLSFNPPQPSRGTDRLDLPVTTRSVHRNFEDRERQ
Sbjct: 841 LPAEAPWARRPVDPRRRSLPAGDALYLSFNPPQPSRGTDRLDLPVTTRSVHRNFEDRERQ 900
Query: 901 ELGSPEERLQDSSDPDTGSEEEGSSRLSPPHSPRDFTRMQDIPEETESRDGEAVASES 958
ELGSPEERLQDSSDPDTGSEEEGSSRLSPPHSPRDFTRMQDIPEETESRDGEAVASES
Sbjct: 901 ELGSPEERLQDSSDPDTGSEEEGSSRLSPPHSPRDFTRMQDIPEETESRDGEAVASES 958
>gi|253735775 Rho/Rac guanine nucleotide exchange factor 2 isoform 1
[Homo sapiens]
Length = 986
Score = 1880 bits (4869), Expect = 0.0
Identities = 958/959 (99%), Positives = 958/959 (99%), Gaps = 1/959 (0%)
Query: 1 MKEAKDARYTNGHLFTTISVSGMTMCYACNKSITAKEALICPTCNVTIHNRCKDTLANCT 60
MKEAKDARYTNGHLFTTISVSGMTMCYACNKSITAKEALICPTCNVTIHNRCKDTLANCT
Sbjct: 28 MKEAKDARYTNGHLFTTISVSGMTMCYACNKSITAKEALICPTCNVTIHNRCKDTLANCT 87
Query: 61 KVKQKQQKAALLKNNTALQSVSLRSKTTIRERPSSAIYPSDSFRQSLLGSRRGRSSLSLA 120
KVKQKQQKAALLKNNTALQSVSLRSKTTIRERPSSAIYPSDSFRQSLLGSRRGRSSLSLA
Sbjct: 88 KVKQKQQKAALLKNNTALQSVSLRSKTTIRERPSSAIYPSDSFRQSLLGSRRGRSSLSLA 147
Query: 121 KSVSTTNIAGHFNDESPLGLRRILSQSTDSLNMRNRTLSVESLIDE-EVIYSELMSDFEM 179
KSVSTTNIAGHFNDESPLGLRRILSQSTDSLNMRNRTLSVESLIDE EVIYSELMSDFEM
Sbjct: 148 KSVSTTNIAGHFNDESPLGLRRILSQSTDSLNMRNRTLSVESLIDEAEVIYSELMSDFEM 207
Query: 180 DEKDFAADSWSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLE 239
DEKDFAADSWSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLE
Sbjct: 208 DEKDFAADSWSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLE 267
Query: 240 ELHLEPGVVQGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLISQFS 299
ELHLEPGVVQGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLISQFS
Sbjct: 268 ELHLEPGVVQGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLISQFS 327
Query: 300 GPSAEQMCKTYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQECILLV 359
GPSAEQMCKTYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQECILLV
Sbjct: 328 GPSAEQMCKTYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQECILLV 387
Query: 360 TQRITKYPLLISRILQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQEIYN 419
TQRITKYPLLISRILQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQEIYN
Sbjct: 388 TQRITKYPLLISRILQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQEIYN 447
Query: 420 RMDPRAQTPVPGKGPFGREELLRRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVFLQEKD 479
RMDPRAQTPVPGKGPFGREELLRRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVFLQEKD
Sbjct: 448 RMDPRAQTPVPGKGPFGREELLRRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVFLQEKD 507
Query: 480 QKYIFPTLDKPSVVSLQNLIVRDIANQEKGMFLISAAPPEMYEVHTASRDDRSTWIRVIQ 539
QKYIFPTLDKPSVVSLQNLIVRDIANQEKGMFLISAAPPEMYEVHTASRDDRSTWIRVIQ
Sbjct: 508 QKYIFPTLDKPSVVSLQNLIVRDIANQEKGMFLISAAPPEMYEVHTASRDDRSTWIRVIQ 567
Query: 540 QSVRTCPSREDFPLIETEDEAYLRRIKMELQQKDRALVELLREKVGLFAEMTHFQAEEDG 599
QSVRTCPSREDFPLIETEDEAYLRRIKMELQQKDRALVELLREKVGLFAEMTHFQAEEDG
Sbjct: 568 QSVRTCPSREDFPLIETEDEAYLRRIKMELQQKDRALVELLREKVGLFAEMTHFQAEEDG 627
Query: 600 GSGMALPTLPRGLFRSESLESPRGERLLQDAIREVEGLKDLLVGPGVELLLTPREPALPL 659
GSGMALPTLPRGLFRSESLESPRGERLLQDAIREVEGLKDLLVGPGVELLLTPREPALPL
Sbjct: 628 GSGMALPTLPRGLFRSESLESPRGERLLQDAIREVEGLKDLLVGPGVELLLTPREPALPL 687
Query: 660 EPDSGGNTSPGVTANGEARTFNGSIELCRADSDSSQRDRNGNQLRSPQEEALQRLVNLYG 719
EPDSGGNTSPGVTANGEARTFNGSIELCRADSDSSQRDRNGNQLRSPQEEALQRLVNLYG
Sbjct: 688 EPDSGGNTSPGVTANGEARTFNGSIELCRADSDSSQRDRNGNQLRSPQEEALQRLVNLYG 747
Query: 720 LLHGLQAAVAQQDTLMEARFPEGPERREKLCRANSRDGEAGRAGAAPVAPEKQATELALL 779
LLHGLQAAVAQQDTLMEARFPEGPERREKLCRANSRDGEAGRAGAAPVAPEKQATELALL
Sbjct: 748 LLHGLQAAVAQQDTLMEARFPEGPERREKLCRANSRDGEAGRAGAAPVAPEKQATELALL 807
Query: 780 QRQHALLQEELRRCRRLGEERATEAGSLEARLRESEQARALLEREAEEARRQLAALGQTE 839
QRQHALLQEELRRCRRLGEERATEAGSLEARLRESEQARALLEREAEEARRQLAALGQTE
Sbjct: 808 QRQHALLQEELRRCRRLGEERATEAGSLEARLRESEQARALLEREAEEARRQLAALGQTE 867
Query: 840 PLPAEAPWARRPVDPRRRSLPAGDALYLSFNPPQPSRGTDRLDLPVTTRSVHRNFEDRER 899
PLPAEAPWARRPVDPRRRSLPAGDALYLSFNPPQPSRGTDRLDLPVTTRSVHRNFEDRER
Sbjct: 868 PLPAEAPWARRPVDPRRRSLPAGDALYLSFNPPQPSRGTDRLDLPVTTRSVHRNFEDRER 927
Query: 900 QELGSPEERLQDSSDPDTGSEEEGSSRLSPPHSPRDFTRMQDIPEETESRDGEAVASES 958
QELGSPEERLQDSSDPDTGSEEEGSSRLSPPHSPRDFTRMQDIPEETESRDGEAVASES
Sbjct: 928 QELGSPEERLQDSSDPDTGSEEEGSSRLSPPHSPRDFTRMQDIPEETESRDGEAVASES 986
>gi|31563330 A-kinase anchor protein 13 isoform 1 [Homo sapiens]
Length = 2817
Score = 574 bits (1479), Expect = e-163
Identities = 361/869 (41%), Positives = 531/869 (61%), Gaps = 51/869 (5%)
Query: 5 KDARYTNGHLFTTISVSGMTMCYACNKSITAKEALICPTCNVTIHNRCKDTLANCTKVKQ 64
KD + NGH F++I V G C C K T K+A C C+ +H C+++LA+C KVK
Sbjct: 1788 KDKKTVNGHTFSSIPVVGPISCSQCMKPFTNKDAYTCANCSAFVHKGCRESLASCAKVKM 1847
Query: 65 KQQKAALLKNNTA-LQSVSLRSKTTI-RERPSSAIYPSDSFRQS-LLGSRRGRSSLSLAK 121
KQ K +L ++T+ L +V +R+K + +ERP SA+ D + + +RR + S+SL+K
Sbjct: 1848 KQPKGSLQAHDTSSLPTVIMRNKPSQPKERPRSAVLLVDETATTPIFANRRSQQSVSLSK 1907
Query: 122 SVSTTNIAGHFNDESPLGLRRILSQSTDSLNMRNRTL-SVESLIDE----EVIYSELMSD 176
SVS NI G NDE+ + LS STDSLN ++ S ESL DE ++ +L+ D
Sbjct: 1908 SVSIQNITGVGNDENMSNTWKFLSHSTDSLNKISKVNESTESLTDEGVGTDMNEGQLLGD 1967
Query: 177 FEMDEKDFAADSWSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTG 236
FE++ K A+SWS +DS FL+Q KK+V+K+Q+VIYEL+QTE HHVRTLKIM+ ++ G
Sbjct: 1968 FEIESKQLEAESWSRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQG 2027
Query: 237 MLEELHLEPGVVQGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLIS 296
M+ +L E +V+ LFPC+DEL IH++F ++LER++++L S +NF+I R+GD+L++
Sbjct: 2028 MMADLLFEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVN 2087
Query: 297 QFSGPSAEQMCKTYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQECI 356
QFSG +AE++ KTY +FC +H++++ +K+LYA+DKRFQ F++K +V++R G+ ECI
Sbjct: 2088 QFSGENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECI 2147
Query: 357 LLVTQRITKYPLLISRILQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQE 416
LLVTQRITKYP+L RILQ + E E++DL +L LVK+++ VD + EK RL E
Sbjct: 2148 LLVTQRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNE 2207
Query: 417 IYNRMDPRAQTPVPGKGPFGREELLRRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVFLQ 476
IY + D ++ + F +E+L R+KL+ DG + K A GR K+V +L+TD+LVFLQ
Sbjct: 2208 IYTKTDSKSIMRMKSGQMFAKEDLKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQ 2267
Query: 477 EKDQKYIFPTLD-KPSVVSLQNLIVRDIANQEKGMFLIS--AAPPEMYEVHTASRDDRST 533
EKDQKYIF +LD K +V+SL+ LIVR++A++EKG+FLIS PEM EVH +S+++R++
Sbjct: 2268 EKDQKYIFASLDQKSTVISLKKLIVREVAHEEKGLFLISMGMTDPEMVEVHASSKEERNS 2327
Query: 534 WIRVIQQSVRTCPSREDFPL-IETEDEAYL-----RRIKMELQQKDRALVELLREKVGLF 587
WI++IQ ++ T ED + E E+E + R +K +L QKD+ ++ LL EK +F
Sbjct: 2328 WIQIIQDTINTLNRDEDEGIPSENEEEKKMLDTRARELKEQLHQKDQKILLLLEEKEMIF 2387
Query: 588 AEMTHFQA--EEDGGSGMALPT-LPRGLFRSESLESPRGERLLQDAIREVEGLKDLLVGP 644
+M ED PT PR LFRS + E+ +G L++ AI EVE L+ L+ G
Sbjct: 2388 RDMAECSTPLPED-----CSPTHSPRVLFRSNTEEALKGGPLMKSAINEVEILQGLVSGN 2442
Query: 645 -GVELLLTPREP---------ALPLEPDS-GGNTSPGVTAN--GEARTFNGSIELCRADS 691
G L T P +LP ++ GG S + A+ GE + +L R +S
Sbjct: 2443 LGGTLGPTVSSPIEQDVVGPVSLPRRAETFGGFDSHQMNASKGGEKEEGDDGQDLRRTES 2502
Query: 692 DSSQRDRNGN-----QLRSPQEEALQRLVNLYGLLHGLQAAVAQQDTLMEARFPEGPERR 746
DS + + GN L+ E+ +Q +V+LY LL LQ V QQD+ +E + ER
Sbjct: 2503 DSGLK-KGGNANLVFMLKRNSEQVVQSVVHLYELLSALQGVVLQQDSYIEDQKLVLSER- 2560
Query: 747 EKLCRANSRDGEAGRAGAAPVAPEKQATELALLQRQHALLQEELRRCRRLGEERATEAGS 806
L R+ SR + EKQ +LA LQ+Q A EE RR R E R E
Sbjct: 2561 -ALTRSLSRPSSLIEQ-EKQRSLEKQRQDLANLQKQQAQYLEEKRRREREWEARERELRE 2618
Query: 807 LEA----RLRESEQARALLEREAEEARRQ 831
EA R E +Q + LE+E EE +++
Sbjct: 2619 REALLAQREEEVQQGQQDLEKEREELQQK 2647
>gi|21493031 A-kinase anchor protein 13 isoform 3 [Homo sapiens]
Length = 1058
Score = 574 bits (1479), Expect = e-163
Identities = 361/869 (41%), Positives = 531/869 (61%), Gaps = 51/869 (5%)
Query: 5 KDARYTNGHLFTTISVSGMTMCYACNKSITAKEALICPTCNVTIHNRCKDTLANCTKVKQ 64
KD + NGH F++I V G C C K T K+A C C+ +H C+++LA+C KVK
Sbjct: 29 KDKKTVNGHTFSSIPVVGPISCSQCMKPFTNKDAYTCANCSAFVHKGCRESLASCAKVKM 88
Query: 65 KQQKAALLKNNTA-LQSVSLRSKTTI-RERPSSAIYPSDSFRQS-LLGSRRGRSSLSLAK 121
KQ K +L ++T+ L +V +R+K + +ERP SA+ D + + +RR + S+SL+K
Sbjct: 89 KQPKGSLQAHDTSSLPTVIMRNKPSQPKERPRSAVLLVDETATTPIFANRRSQQSVSLSK 148
Query: 122 SVSTTNIAGHFNDESPLGLRRILSQSTDSLNMRNRTL-SVESLIDE----EVIYSELMSD 176
SVS NI G NDE+ + LS STDSLN ++ S ESL DE ++ +L+ D
Sbjct: 149 SVSIQNITGVGNDENMSNTWKFLSHSTDSLNKISKVNESTESLTDEGVGTDMNEGQLLGD 208
Query: 177 FEMDEKDFAADSWSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTG 236
FE++ K A+SWS +DS FL+Q KK+V+K+Q+VIYEL+QTE HHVRTLKIM+ ++ G
Sbjct: 209 FEIESKQLEAESWSRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQG 268
Query: 237 MLEELHLEPGVVQGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLIS 296
M+ +L E +V+ LFPC+DEL IH++F ++LER++++L S +NF+I R+GD+L++
Sbjct: 269 MMADLLFEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVN 328
Query: 297 QFSGPSAEQMCKTYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQECI 356
QFSG +AE++ KTY +FC +H++++ +K+LYA+DKRFQ F++K +V++R G+ ECI
Sbjct: 329 QFSGENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECI 388
Query: 357 LLVTQRITKYPLLISRILQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQE 416
LLVTQRITKYP+L RILQ + E E++DL +L LVK+++ VD + EK RL E
Sbjct: 389 LLVTQRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNE 448
Query: 417 IYNRMDPRAQTPVPGKGPFGREELLRRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVFLQ 476
IY + D ++ + F +E+L R+KL+ DG + K A GR K+V +L+TD+LVFLQ
Sbjct: 449 IYTKTDSKSIMRMKSGQMFAKEDLKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQ 508
Query: 477 EKDQKYIFPTLD-KPSVVSLQNLIVRDIANQEKGMFLIS--AAPPEMYEVHTASRDDRST 533
EKDQKYIF +LD K +V+SL+ LIVR++A++EKG+FLIS PEM EVH +S+++R++
Sbjct: 509 EKDQKYIFASLDQKSTVISLKKLIVREVAHEEKGLFLISMGMTDPEMVEVHASSKEERNS 568
Query: 534 WIRVIQQSVRTCPSREDFPL-IETEDEAYL-----RRIKMELQQKDRALVELLREKVGLF 587
WI++IQ ++ T ED + E E+E + R +K +L QKD+ ++ LL EK +F
Sbjct: 569 WIQIIQDTINTLNRDEDEGIPSENEEEKKMLDTRARELKEQLHQKDQKILLLLEEKEMIF 628
Query: 588 AEMTHFQA--EEDGGSGMALPT-LPRGLFRSESLESPRGERLLQDAIREVEGLKDLLVGP 644
+M ED PT PR LFRS + E+ +G L++ AI EVE L+ L+ G
Sbjct: 629 RDMAECSTPLPED-----CSPTHSPRVLFRSNTEEALKGGPLMKSAINEVEILQGLVSGN 683
Query: 645 -GVELLLTPREP---------ALPLEPDS-GGNTSPGVTAN--GEARTFNGSIELCRADS 691
G L T P +LP ++ GG S + A+ GE + +L R +S
Sbjct: 684 LGGTLGPTVSSPIEQDVVGPVSLPRRAETFGGFDSHQMNASKGGEKEEGDDGQDLRRTES 743
Query: 692 DSSQRDRNGN-----QLRSPQEEALQRLVNLYGLLHGLQAAVAQQDTLMEARFPEGPERR 746
DS + + GN L+ E+ +Q +V+LY LL LQ V QQD+ +E + ER
Sbjct: 744 DSGLK-KGGNANLVFMLKRNSEQVVQSVVHLYELLSALQGVVLQQDSYIEDQKLVLSER- 801
Query: 747 EKLCRANSRDGEAGRAGAAPVAPEKQATELALLQRQHALLQEELRRCRRLGEERATEAGS 806
L R+ SR + EKQ +LA LQ+Q A EE RR R E R E
Sbjct: 802 -ALTRSLSRPSSLIEQ-EKQRSLEKQRQDLANLQKQQAQYLEEKRRREREWEARERELRE 859
Query: 807 LEA----RLRESEQARALLEREAEEARRQ 831
EA R E +Q + LE+E EE +++
Sbjct: 860 REALLAQREEEVQQGQQDLEKEREELQQK 888
>gi|21493029 A-kinase anchor protein 13 isoform 2 [Homo sapiens]
Length = 2813
Score = 574 bits (1479), Expect = e-163
Identities = 361/869 (41%), Positives = 531/869 (61%), Gaps = 51/869 (5%)
Query: 5 KDARYTNGHLFTTISVSGMTMCYACNKSITAKEALICPTCNVTIHNRCKDTLANCTKVKQ 64
KD + NGH F++I V G C C K T K+A C C+ +H C+++LA+C KVK
Sbjct: 1784 KDKKTVNGHTFSSIPVVGPISCSQCMKPFTNKDAYTCANCSAFVHKGCRESLASCAKVKM 1843
Query: 65 KQQKAALLKNNTA-LQSVSLRSKTTI-RERPSSAIYPSDSFRQS-LLGSRRGRSSLSLAK 121
KQ K +L ++T+ L +V +R+K + +ERP SA+ D + + +RR + S+SL+K
Sbjct: 1844 KQPKGSLQAHDTSSLPTVIMRNKPSQPKERPRSAVLLVDETATTPIFANRRSQQSVSLSK 1903
Query: 122 SVSTTNIAGHFNDESPLGLRRILSQSTDSLNMRNRTL-SVESLIDE----EVIYSELMSD 176
SVS NI G NDE+ + LS STDSLN ++ S ESL DE ++ +L+ D
Sbjct: 1904 SVSIQNITGVGNDENMSNTWKFLSHSTDSLNKISKVNESTESLTDEGVGTDMNEGQLLGD 1963
Query: 177 FEMDEKDFAADSWSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTG 236
FE++ K A+SWS +DS FL+Q KK+V+K+Q+VIYEL+QTE HHVRTLKIM+ ++ G
Sbjct: 1964 FEIESKQLEAESWSRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQG 2023
Query: 237 MLEELHLEPGVVQGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLIS 296
M+ +L E +V+ LFPC+DEL IH++F ++LER++++L S +NF+I R+GD+L++
Sbjct: 2024 MMADLLFEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVN 2083
Query: 297 QFSGPSAEQMCKTYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQECI 356
QFSG +AE++ KTY +FC +H++++ +K+LYA+DKRFQ F++K +V++R G+ ECI
Sbjct: 2084 QFSGENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECI 2143
Query: 357 LLVTQRITKYPLLISRILQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQE 416
LLVTQRITKYP+L RILQ + E E++DL +L LVK+++ VD + EK RL E
Sbjct: 2144 LLVTQRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNE 2203
Query: 417 IYNRMDPRAQTPVPGKGPFGREELLRRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVFLQ 476
IY + D ++ + F +E+L R+KL+ DG + K A GR K+V +L+TD+LVFLQ
Sbjct: 2204 IYTKTDSKSIMRMKSGQMFAKEDLKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQ 2263
Query: 477 EKDQKYIFPTLD-KPSVVSLQNLIVRDIANQEKGMFLIS--AAPPEMYEVHTASRDDRST 533
EKDQKYIF +LD K +V+SL+ LIVR++A++EKG+FLIS PEM EVH +S+++R++
Sbjct: 2264 EKDQKYIFASLDQKSTVISLKKLIVREVAHEEKGLFLISMGMTDPEMVEVHASSKEERNS 2323
Query: 534 WIRVIQQSVRTCPSREDFPL-IETEDEAYL-----RRIKMELQQKDRALVELLREKVGLF 587
WI++IQ ++ T ED + E E+E + R +K +L QKD+ ++ LL EK +F
Sbjct: 2324 WIQIIQDTINTLNRDEDEGIPSENEEEKKMLDTRARELKEQLHQKDQKILLLLEEKEMIF 2383
Query: 588 AEMTHFQA--EEDGGSGMALPT-LPRGLFRSESLESPRGERLLQDAIREVEGLKDLLVGP 644
+M ED PT PR LFRS + E+ +G L++ AI EVE L+ L+ G
Sbjct: 2384 RDMAECSTPLPED-----CSPTHSPRVLFRSNTEEALKGGPLMKSAINEVEILQGLVSGN 2438
Query: 645 -GVELLLTPREP---------ALPLEPDS-GGNTSPGVTAN--GEARTFNGSIELCRADS 691
G L T P +LP ++ GG S + A+ GE + +L R +S
Sbjct: 2439 LGGTLGPTVSSPIEQDVVGPVSLPRRAETFGGFDSHQMNASKGGEKEEGDDGQDLRRTES 2498
Query: 692 DSSQRDRNGN-----QLRSPQEEALQRLVNLYGLLHGLQAAVAQQDTLMEARFPEGPERR 746
DS + + GN L+ E+ +Q +V+LY LL LQ V QQD+ +E + ER
Sbjct: 2499 DSGLK-KGGNANLVFMLKRNSEQVVQSVVHLYELLSALQGVVLQQDSYIEDQKLVLSER- 2556
Query: 747 EKLCRANSRDGEAGRAGAAPVAPEKQATELALLQRQHALLQEELRRCRRLGEERATEAGS 806
L R+ SR + EKQ +LA LQ+Q A EE RR R E R E
Sbjct: 2557 -ALTRSLSRPSSLIEQ-EKQRSLEKQRQDLANLQKQQAQYLEEKRRREREWEARERELRE 2614
Query: 807 LEA----RLRESEQARALLEREAEEARRQ 831
EA R E +Q + LE+E EE +++
Sbjct: 2615 REALLAQREEEVQQGQQDLEKEREELQQK 2643
>gi|122937434 Rho-guanine nucleotide exchange factor [Homo sapiens]
Length = 1651
Score = 509 bits (1310), Expect = e-144
Identities = 331/876 (37%), Positives = 482/876 (55%), Gaps = 65/876 (7%)
Query: 2 KEAKDARYTNGHLFTTISVSGMTMCYACNKSITAKEALICPTCNVTIHNRCKDTLANCTK 61
K+AKD N H F + SG+ C C+K++ KE+L C CN +H CKD CTK
Sbjct: 642 KDAKDKEKLNRHQFAPGTFSGVLQCLVCDKTLLGKESLQCSNCNANVHKGCKDAAPACTK 701
Query: 62 VKQKQQKAALLKNNTALQSVSLRSKTTIRERPSSAIYPSDSFRQSLLGSRRGRSSL--SL 119
+ Q+K K T L + S R +P +++PS S L RR L
Sbjct: 702 --KFQEKYNKNKPQTILGNSSFRDIP----QPGLSLHPSSSVPVGLPTGRRETVGQVHPL 755
Query: 120 AKSVSTTNI------AGHFNDESPLGLRRILSQSTDSLNMRNRTLSVESLIDEEVIYSEL 173
++SV T + A ES R S S + L + S ES I E+V+ S L
Sbjct: 756 SRSVPGTTLESFRRSATSLESESDHNSCRSRSHSDELLQSMGSSPSTESFIMEDVVDSSL 815
Query: 174 MSDFEMDEKDFAADSWSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLF 233
SD D ++F A+SWSL VD SF + +K+V+K+QDVI+EL+QTE+HH++TL IM+ +F
Sbjct: 816 WSDLSSDAQEFEAESWSLVVDPSFCNRQEKDVIKRQDVIFELMQTEMHHIQTLFIMSEIF 875
Query: 234 RTGMLEELHLEPGVVQGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDL 293
R GM EEL L+ V +FPC+DEL +IH F + ERR+++ C GS RNFVI R+GD+
Sbjct: 876 RKGMKEELQLDHSTVDKIFPCLDELLEIHRHFFYSMKERRQES-CAGSDRNFVIDRIGDI 934
Query: 294 LISQFSGPSAEQMCKTYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQ 353
L+ QFS +A +M K Y EFC H +A+ L+KEL ++K+FQ FI+ + +R G+
Sbjct: 935 LVQQFSEENASKMKKIYGEFCCHHKEAVNLFKEL-QQNKKFQNFIKLRNSNLLARRRGIP 993
Query: 354 ECILLVTQRITKYPLLISRILQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGAR 413
ECILLVTQRITKYP+L+ RILQ++ EE +DL AL L+K++++ VD + + EK +
Sbjct: 994 ECILLVTQRITKYPVLVERILQYTKERTEEHKDLRKALCLIKDMIATVDLKVNEYEKNQK 1053
Query: 414 LQEIYNRMDPRAQTPVPGKGPFGREELL--RRKLIHDGCLLWKTATGRFKDVLVLLMTDV 471
EI N+++ + T + F ++ L+ R L++DG + WKTATGRFKD+L LL+TDV
Sbjct: 1054 WLEILNKIENKTYTKLKNGHVFRKQALMSEERTLLYDGLVYWKTATGRFKDILALLLTDV 1113
Query: 472 LVFLQEKDQKYIFPTLD-KPSVVSLQNLIVRDIANQEKGMFLISA--APPEMYEVHTASR 528
L+FLQEKDQKYIF +D KPSV+SLQ LI R++AN+E+GMFLISA A PEMYE+HT S+
Sbjct: 1114 LLFLQEKDQKYIFAAVDQKPSVISLQKLIAREVANEERGMFLISASSAGPEMYEIHTNSK 1173
Query: 529 DDRSTWIRVIQQSVRTCPSREDFPLIETEDE--------AYLRRIKMELQQKDRALVELL 580
++R+ W+R IQQ+V +CP + E++++ A +++ + L +D+ + L
Sbjct: 1174 EERNNWMRRIQQAVESCPEEKGGRTSESDEDKRKAEARVAKIQQCQEILTNQDQQICAYL 1233
Query: 581 REKVGLFAEMTHFQAEEDGGSGMALPTLPRGLFRSESLESPRGERLLQDAIREVEGLKDL 640
EK+ ++AE+ ED + P L + + E P+ LL A++E E L+
Sbjct: 1234 EEKLHIYAELGELSGFED------VHLEPHLLIKPDPGEPPQAASLLAAALKEAESLQVA 1287
Query: 641 LVGPGVELLLTPREPA---------LPLEPDSGGNTSPGVTANGEARTFNG------SIE 685
+ + + E + L G T+ VT E R + +
Sbjct: 1288 VKASQMGAVSQSCEDSCGDSVLADTLSSHDVPGSPTASLVTGGREGRGCSDVDPGIQGVV 1347
Query: 686 LCRADSDSSQRDRNGNQLRSPQEEALQRLVNLYGLLHGLQAAVAQQDTLME-----ARFP 740
A SD+ ++ N S Q E +Q + NL LL+ LQAA+ QD+ +E +
Sbjct: 1348 TDLAVSDAGEKVECRNFPGSSQSEIIQAIQNLTRLLYSLQAALTIQDSHIEIHRLVLQQQ 1407
Query: 741 EGPERREKLCRANSRDGEAGRAGAAPVAPEKQATELA-LLQRQHALLQEE---LRRCRRL 796
EG + R + R ++Q ELA + Q QH L QE+ LRRC +
Sbjct: 1408 EGLSLGHSILRGGPLQDQKSRDA------DRQHEELANVHQLQHQLQQEQRRWLRRCEQQ 1461
Query: 797 GEERATEAGSLEARLRESEQARALLEREAEEARRQL 832
+AT L+ R RE + LL R E QL
Sbjct: 1462 QRAQATRESWLQERERECQSQEELLLRSRGELDLQL 1497
>gi|195972857 Rho/Rac guanine nucleotide exchange factor 18 isoform
b [Homo sapiens]
Length = 1173
Score = 467 bits (1201), Expect = e-131
Identities = 306/823 (37%), Positives = 459/823 (55%), Gaps = 79/823 (9%)
Query: 72 LKNNTALQSVSLRSKTTIRERPSSAIYPSDSFRQSLLGSRRGRSSLSLAKSVSTTN---I 128
L N+ L SV+ K R S P+ S + S++G + + + T I
Sbjct: 124 LSTNSVLASVTASLKEHPRGTLLSDGSPALSRNVGMTVSQKGGPQPTPSPAGPGTQLGPI 183
Query: 129 AGHFNDESPLGLRRILSQSTDSLNMRNRTLSVESLIDEEVIYSELMSDFEMDEKDFAADS 188
G DE+ + + DSL++ + + ES+ E+ + L S+ E D +F A+S
Sbjct: 184 TGEM-DEADSAFLKFKQTADDSLSLTSP--NTESIFVEDPYTASLRSEIESDGHEFEAES 240
Query: 189 WSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELHLEPGVV 248
WSLAVD+++ ++ K+EV+K+QDV+YEL+QTE+HHVRTLKIM +++ + EEL +
Sbjct: 241 WSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQFSSKAI 300
Query: 249 QGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCK 308
LFPC D+L + H+ FL++L ERR+++L GS RN+VI ++GDLL+ QFSG + E+M +
Sbjct: 301 GRLFPCADDLLETHSHFLARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKE 360
Query: 309 TYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQECILLVTQRITKYPL 368
Y FCS H++A+ YK L ++K+FQ I+K+ ++++R GVQECILLVTQRITKYP+
Sbjct: 361 KYGVFCSGHNEAVSHYKLLLQQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPV 420
Query: 369 LISRILQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQEIYNRMDPRAQTP 428
L+ RI+Q++ E+ +DLT AL L+K+++S VD + + EKG RL+EI +MD ++ +
Sbjct: 421 LVERIIQNTEAGTEDYEDLTQALNLIKDIISQVDAKVSECEKGQRLREIAGKMDLKSSSK 480
Query: 429 VPGKGPFGREELLRRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVFLQEKDQKYIFPTLD 488
+ F +E++L+R+L +G L WKT +GR KD+L +L+TDVL+ LQEKDQKY+F ++D
Sbjct: 481 LKNGLTFRKEDMLQRQLHLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQKYVFASVD 540
Query: 489 -KPSVVSLQNLIVRDIANQEKGMFLISAA--PPEMYEVHTASRDDRSTWIRVIQQSVRTC 545
KP V+SLQ LIVR++AN+EK MFLISA+ PEMYE++T+S++DR+ W+ IQ++V +C
Sbjct: 541 SKPPVISLQKLIVREVANEEKAMFLISASLQGPEMYEIYTSSKEDRNAWMAHIQRAVESC 600
Query: 546 PSREDFPLIETEDE--------AYLRRIKMELQQKDRALVELLREKVGLFAEMTHFQAEE 597
P E+ P E+E LR + L KD+ + + L EK ++ EM E
Sbjct: 601 PDEEEGPFSLPEEERKVVEARATRLRDFQERLSMKDQLIAQSLLEKQQIYLEMAEMGGLE 660
Query: 598 DGGSGMALPTLPRGLFR-SESLESPRGERLLQDAIREVEGLKDLLVGPGVELLLTPREPA 656
D LP PRGLFR + E+ +GE +L+ A+ E+EG++ L+ A
Sbjct: 661 D------LPQ-PRGLFRGGDPSETLQGELILKSAMSEIEGIQ--------SLICRQLGSA 705
Query: 657 LPLEPDSGGNTSPGVTAN-------GEARTFNGSIELCRADSDSSQRDRN---------- 699
D G +T P A + T NGS + + +D RD
Sbjct: 706 NGQAEDGGSSTGPPRRAETFAGYDCTNSPTKNGSFKKKVSSTDPRPRDWRGPPNSPDLKL 765
Query: 700 ------GNQLRSPQ------------------EEALQRLVNLYGLLHGLQAAVAQQDTLM 735
G+ SPQ E +QR+ L LL LQA +A QD+ +
Sbjct: 766 SDSDIPGSSEESPQVVEAPGTESDPRLPTVLESELVQRIQTLSQLLLNLQAVIAHQDSYV 825
Query: 736 EARFPEGPERREKLCRANSRDGEAGRAGAAPVAPEKQATELALLQRQHALLQEELRRCRR 795
E + + REK R S G EKQ E A L++ + L+ E +R R
Sbjct: 826 ETQ-RAAIQEREKQFRLQSTRGNLLLEQERQRNFEKQREERAALEKLQSQLRHEQQRWER 884
Query: 796 LGEERATEAGSLEARLRESE----QARALLEREAEEARRQLAA 834
+ + E ARL+E E Q R LE+E E RQ A
Sbjct: 885 ERQWQHQELERAGARLQEREGEARQLRERLEQERAELERQRQA 927
>gi|41327769 Rho/Rac guanine nucleotide exchange factor 18 isoform a
[Homo sapiens]
Length = 1015
Score = 466 bits (1200), Expect = e-131
Identities = 291/758 (38%), Positives = 435/758 (57%), Gaps = 75/758 (9%)
Query: 134 DESPLGLRRILSQSTDSLNMRNRTLSVESLIDEEVIYSELMSDFEMDEKDFAADSWSLAV 193
DE+ + + DSL++ + + ES+ E+ + L S+ E D +F A+SWSLAV
Sbjct: 30 DEADSAFLKFKQTADDSLSLTSP--NTESIFVEDPYTASLRSEIESDGHEFEAESWSLAV 87
Query: 194 DSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELHLEPGVVQGLFP 253
D+++ ++ K+EV+K+QDV+YEL+QTE+HHVRTLKIM +++ + EEL + LFP
Sbjct: 88 DAAYAKKQKREVVKRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQFSSKAIGRLFP 147
Query: 254 CVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCKTYSEF 313
C D+L + H+ FL++L ERR+++L GS RN+VI ++GDLL+ QFSG + E+M + Y F
Sbjct: 148 CADDLLETHSHFLARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKEKYGVF 207
Query: 314 CSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQECILLVTQRITKYPLLISRI 373
CS H++A+ YK L ++K+FQ I+K+ ++++R GVQECILLVTQRITKYP+L+ RI
Sbjct: 208 CSGHNEAVSHYKLLLQQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPVLVERI 267
Query: 374 LQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQEIYNRMDPRAQTPVPGKG 433
+Q++ E+ +DLT AL L+K+++S VD + + EKG RL+EI +MD ++ + +
Sbjct: 268 IQNTEAGTEDYEDLTQALNLIKDIISQVDAKVSECEKGQRLREIAGKMDLKSSSKLKNGL 327
Query: 434 PFGREELLRRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVFLQEKDQKYIFPTLD-KPSV 492
F +E++L+R+L +G L WKT +GR KD+L +L+TDVL+ LQEKDQKY+F ++D KP V
Sbjct: 328 TFRKEDMLQRQLHLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQKYVFASVDSKPPV 387
Query: 493 VSLQNLIVRDIANQEKGMFLISAA--PPEMYEVHTASRDDRSTWIRVIQQSVRTCPSRED 550
+SLQ LIVR++AN+EK MFLISA+ PEMYE++T+S++DR+ W+ IQ++V +CP E+
Sbjct: 388 ISLQKLIVREVANEEKAMFLISASLQGPEMYEIYTSSKEDRNAWMAHIQRAVESCPDEEE 447
Query: 551 FPLIETEDE--------AYLRRIKMELQQKDRALVELLREKVGLFAEMTHFQAEEDGGSG 602
P E+E LR + L KD+ + + L EK ++ EM ED
Sbjct: 448 GPFSLPEEERKVVEARATRLRDFQERLSMKDQLIAQSLLEKQQIYLEMAEMGGLED---- 503
Query: 603 MALPTLPRGLFR-SESLESPRGERLLQDAIREVEGLKDLLVGPGVELLLTPREPALPLEP 661
LP PRGLFR + E+ +GE +L+ A+ E+EG++ L+ A
Sbjct: 504 --LPQ-PRGLFRGGDPSETLQGELILKSAMSEIEGIQ--------SLICRQLGSANGQAE 552
Query: 662 DSGGNTSPGVTAN-------GEARTFNGSIELCRADSDSSQRDRN--------------- 699
D G +T P A + T NGS + + +D RD
Sbjct: 553 DGGSSTGPPRRAETFAGYDCTNSPTKNGSFKKKVSSTDPRPRDWRGPPNSPDLKLSDSDI 612
Query: 700 -GNQLRSPQ------------------EEALQRLVNLYGLLHGLQAAVAQQDTLMEARFP 740
G+ SPQ E +QR+ L LL LQA +A QD+ +E +
Sbjct: 613 PGSSEESPQVVEAPGTESDPRLPTVLESELVQRIQTLSQLLLNLQAVIAHQDSYVETQ-R 671
Query: 741 EGPERREKLCRANSRDGEAGRAGAAPVAPEKQATELALLQRQHALLQEELRRCRRLGEER 800
+ REK R S G EKQ E A L++ + L+ E +R R + +
Sbjct: 672 AAIQEREKQFRLQSTRGNLLLEQERQRNFEKQREERAALEKLQSQLRHEQQRWERERQWQ 731
Query: 801 ATEAGSLEARLRESE----QARALLEREAEEARRQLAA 834
E ARL+E E Q R LE+E E RQ A
Sbjct: 732 HQELERAGARLQEREGEARQLRERLEQERAELERQRQA 769
>gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isoform 2
[Homo sapiens]
Length = 1562
Score = 185 bits (470), Expect = 2e-46
Identities = 128/453 (28%), Positives = 231/453 (50%), Gaps = 38/453 (8%)
Query: 110 SRRGRSSLSLAKSVSTTNIAGHFNDESPLGLRRILSQSTDSLNMRNRTLSVESLIDEEVI 169
+R +S+ S S+ST ++ +P RR S + SL TL L D+
Sbjct: 686 TRLHQSASSSTSSLSTRSLENPTPPFTPKMGRR--SIESPSLGFCTDTLLPHLLEDDLGQ 743
Query: 170 YSELMSDFEMDEKDFAADSWSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIM 229
S+L E + A +W V + + + +Q+VI EL TE H+RTL+++
Sbjct: 744 LSDL-------EPEPDAQNWQHTVGKDVVAGLTQREIDRQEVINELFVTEASHLRTLRVL 796
Query: 230 TRLFRTGMLEELHLEPGVVQGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHR 289
+F M +E + + LFP + EL +IH + + + R + +I
Sbjct: 797 DLIFYQRMKKENLMPREELARLFPNLPELIEIHNSWCEAMKKLREEGP--------IIKE 848
Query: 290 LGDLLISQFSGPSAEQMCKTYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKR 349
+ DL++++F GP+ E++ + ++FCS S AL+L K ++ RFQ F+++ +R
Sbjct: 849 ISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQLFMQEAESHPQCRR 908
Query: 350 HGVQECILLVTQRITKYPLLISRILQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQLE 409
+++ I+ QR+TKYPLL+ I++H+ G E + L A +E+L V+E + Q E
Sbjct: 909 LQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQCREILKYVNEAVKQTE 968
Query: 410 KGARLQEIYNRMD----PRAQTPVPGKGPFGREELLRRKLIHDGCLLWKTATGRFKDVLV 465
RL+ R+D RA P+ + F +L RK+IH+G L W+ + + D+ V
Sbjct: 969 NRHRLEGYQKRLDATALERASNPLAAE--FKSLDLTTRKMIHEGPLTWRISKDKTLDLHV 1026
Query: 466 LLMTDVLVFLQEKDQKYIFPTLDKPS------------VVSLQNLIVRDIANQEKGMFLI 513
LL+ D+LV LQ++D+K + K + V+ L +++R +A ++ F+I
Sbjct: 1027 LLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIRSVATDKRAFFII 1086
Query: 514 SAA---PPEMYEVHTASRDDRSTWIRVIQQSVR 543
+ PP++YE+ + D++TW+ +++++VR
Sbjct: 1087 CTSKLGPPQIYELVALTSSDKNTWMELLEEAVR 1119
>gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isoform 1
[Homo sapiens]
Length = 1522
Score = 185 bits (470), Expect = 2e-46
Identities = 128/453 (28%), Positives = 231/453 (50%), Gaps = 38/453 (8%)
Query: 110 SRRGRSSLSLAKSVSTTNIAGHFNDESPLGLRRILSQSTDSLNMRNRTLSVESLIDEEVI 169
+R +S+ S S+ST ++ +P RR S + SL TL L D+
Sbjct: 646 TRLHQSASSSTSSLSTRSLENPTPPFTPKMGRR--SIESPSLGFCTDTLLPHLLEDDLGQ 703
Query: 170 YSELMSDFEMDEKDFAADSWSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIM 229
S+L E + A +W V + + + +Q+VI EL TE H+RTL+++
Sbjct: 704 LSDL-------EPEPDAQNWQHTVGKDVVAGLTQREIDRQEVINELFVTEASHLRTLRVL 756
Query: 230 TRLFRTGMLEELHLEPGVVQGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHR 289
+F M +E + + LFP + EL +IH + + + R + +I
Sbjct: 757 DLIFYQRMKKENLMPREELARLFPNLPELIEIHNSWCEAMKKLREEGP--------IIKE 808
Query: 290 LGDLLISQFSGPSAEQMCKTYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKR 349
+ DL++++F GP+ E++ + ++FCS S AL+L K ++ RFQ F+++ +R
Sbjct: 809 ISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQLFMQEAESHPQCRR 868
Query: 350 HGVQECILLVTQRITKYPLLISRILQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQLE 409
+++ I+ QR+TKYPLL+ I++H+ G E + L A +E+L V+E + Q E
Sbjct: 869 LQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQCREILKYVNEAVKQTE 928
Query: 410 KGARLQEIYNRMD----PRAQTPVPGKGPFGREELLRRKLIHDGCLLWKTATGRFKDVLV 465
RL+ R+D RA P+ + F +L RK+IH+G L W+ + + D+ V
Sbjct: 929 NRHRLEGYQKRLDATALERASNPLAAE--FKSLDLTTRKMIHEGPLTWRISKDKTLDLHV 986
Query: 466 LLMTDVLVFLQEKDQKYIFPTLDKPS------------VVSLQNLIVRDIANQEKGMFLI 513
LL+ D+LV LQ++D+K + K + V+ L +++R +A ++ F+I
Sbjct: 987 LLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIRSVATDKRAFFII 1046
Query: 514 SAA---PPEMYEVHTASRDDRSTWIRVIQQSVR 543
+ PP++YE+ + D++TW+ +++++VR
Sbjct: 1047 CTSKLGPPQIYELVALTSSDKNTWMELLEEAVR 1079
>gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo
sapiens]
Length = 1544
Score = 171 bits (433), Expect = 3e-42
Identities = 138/546 (25%), Positives = 248/546 (45%), Gaps = 56/546 (10%)
Query: 80 SVSLRSKTTIRERPSSAIYPSDSFRQSLLGS----RRGRSSLSLAKSVSTTNIAGHFNDE 135
S LR E + P++S G+ G+ + + +K V T+ G D
Sbjct: 643 SAKLRQSGLANEGTDAGYLPANSMSSVASGASFSQEGGKENDTGSKQVGETSAPGDTLDG 702
Query: 136 SPLGLRRILSQSTDSLN-MRNRTLSVESLID----------EEVIYSELMSDFEMDEKDF 184
+P L + L+ ++ VE + + + V + E S+ E E D
Sbjct: 703 TPRTLNTVFDFPPPPLDQVQEEECEVERVTEHGTPKPFRKFDSVAFGESQSEDEQFENDL 762
Query: 185 AAD--SWSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELH 242
D +W V L K +K+Q+VI EL TE HVRTLK++ ++F + E
Sbjct: 763 ETDPPNWQQLVSREVLLGLKPCEIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSREGI 822
Query: 243 LEPGVVQGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLISQFSGPS 302
L P ++ +F ++++ +H Q+ R++ VI ++G+ L++ FSGP
Sbjct: 823 LSPSELRKIFSNLEDILQLHIGLNEQMKAVRKR------NETSVIDQIGEDLLTWFSGPG 876
Query: 303 AEQMCKTYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQECILLVTQR 362
E++ + FCS AL++ K +D RFQ F++ + +R +++ I QR
Sbjct: 877 EEKLKHAAATFCSNQPFALEMIKSRQKKDSRFQTFVQDAESNPLCRRLQLKDIIPTQMQR 936
Query: 363 ITKYPLLISRILQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQEIYNRMD 422
+TKYPLL+ I +++ ER+ + A +++L+ V++ + + E RL++ R+D
Sbjct: 937 LTKYPLLLDNIAKYTEW-PTEREKVKKAADHCRQILNYVNQAVKEAENKQRLEDYQRRLD 995
Query: 423 PRA--QTPVPGKGPFGREELLRRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVFLQEKDQ 480
+ + P +L +RK+IH+G L+WK + D+ LL+ D+LV LQ++D
Sbjct: 996 TSSLKLSEYPNVEELRNLDLTKRKMIHEGPLVWKVNRDKTIDLYTLLLEDILVLLQKQDD 1055
Query: 481 KYIFPTLDK------------PSVVSLQNLIVRDIANQEKGMFLISAAP--PEMYEVHTA 526
+ + K V+ L ++VR +A K +F+IS + ++YE+
Sbjct: 1056 RLVLRCHSKILASTADSKHTFSPVIKLSTVLVRQVATDNKALFVISMSDNGAQIYELVAQ 1115
Query: 527 SRDDRSTWIRVI--------QQSVRTCPSREDFPLIETEDEAYLRRIKME--------LQ 570
+ +++ W +I +QS + P + P DE ++K E LQ
Sbjct: 1116 TVSEKTVWQDLICRMAASVKEQSTKPIPLPQSTPGEGDNDEEDPSKLKEEQHGISVTGLQ 1175
Query: 571 QKDRAL 576
DR L
Sbjct: 1176 SPDRDL 1181
>gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1
[Homo sapiens]
Length = 927
Score = 168 bits (425), Expect = 3e-41
Identities = 142/528 (26%), Positives = 245/528 (46%), Gaps = 65/528 (12%)
Query: 189 WSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELHLEPGVV 248
W V L K +K+Q+VI EL+ TE HVR L+++ LF M E L +
Sbjct: 413 WRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEEL 472
Query: 249 QGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCK 308
Q +FP +DEL ++H+ FL +L++RR+++ ++I +GD+L+++F G K
Sbjct: 473 QNIFPSLDELIEVHSLFLDRLMKRRQES-------GYLIEEIGDVLLARFDGAEGSWFQK 525
Query: 309 TYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQECILLVTQRITKYPL 368
S FCSR S AL+ K +D RF F+++ +R +++ I QR+TKYPL
Sbjct: 526 ISSRFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPL 585
Query: 369 LISRILQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQEIYNRMD--PRAQ 426
L+ I Q++ ER+ + A +E+L +V++ + +E RL++ R+D Q
Sbjct: 586 LLQSIGQNTEE-PTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQ 644
Query: 427 TPVPGKGPFGREELLRRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVFLQEKDQKYIF-- 484
+ P F ++ ++KL+H+G L W+ + +V VLL+ D+L+ LQ +D++ +
Sbjct: 645 SSDPMLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKS 704
Query: 485 ------PTLDKPS----VVSLQNLIVRDIANQEKGMFLISAAPPE--MYEVHTASRDDRS 532
PT D + V+ L + + R++A K +++ E +YE+ + +R
Sbjct: 705 HSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQTVSERK 764
Query: 533 TWIRVIQQSV--------------RTCPSREDFPLIETED-----------EAYLRRIKM 567
W +I ++ R PS PL+ + + +A RI
Sbjct: 765 NWCALITETAGSLKVPAPASRPKPRPSPSSTREPLLSSSENGNGGRETSPADARTERILS 824
Query: 568 EL------QQKDRALVELLREKVGLFAEMTHFQAEEDGGSGMALPTLPRGLFRSESLESP 621
+L + + LR+ + L + F AEED G+G P G+ L
Sbjct: 825 DLLPFCRPGPEGQLAATALRKVLSL--KQLLFPAEEDNGAGP--PRDGDGVPGGGPLSPA 880
Query: 622 RGERLLQDAIREVEGLKDLLVGPGVELLLTPREPALPLEPDSGGNTSP 669
R + + ++ + E +K L E L PL GGN+ P
Sbjct: 881 RTQEIQENLLSLEETMKQL------EELEEEFCRLRPLLSQLGGNSVP 922
>gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3
[Homo sapiens]
Length = 879
Score = 168 bits (425), Expect = 3e-41
Identities = 142/528 (26%), Positives = 245/528 (46%), Gaps = 65/528 (12%)
Query: 189 WSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELHLEPGVV 248
W V L K +K+Q+VI EL+ TE HVR L+++ LF M E L +
Sbjct: 365 WRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEEL 424
Query: 249 QGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCK 308
Q +FP +DEL ++H+ FL +L++RR+++ ++I +GD+L+++F G K
Sbjct: 425 QNIFPSLDELIEVHSLFLDRLMKRRQES-------GYLIEEIGDVLLARFDGAEGSWFQK 477
Query: 309 TYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQECILLVTQRITKYPL 368
S FCSR S AL+ K +D RF F+++ +R +++ I QR+TKYPL
Sbjct: 478 ISSRFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPL 537
Query: 369 LISRILQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQEIYNRMD--PRAQ 426
L+ I Q++ ER+ + A +E+L +V++ + +E RL++ R+D Q
Sbjct: 538 LLQSIGQNTEE-PTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQ 596
Query: 427 TPVPGKGPFGREELLRRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVFLQEKDQKYIF-- 484
+ P F ++ ++KL+H+G L W+ + +V VLL+ D+L+ LQ +D++ +
Sbjct: 597 SSDPMLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKS 656
Query: 485 ------PTLDKPS----VVSLQNLIVRDIANQEKGMFLISAAPPE--MYEVHTASRDDRS 532
PT D + V+ L + + R++A K +++ E +YE+ + +R
Sbjct: 657 HSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQTVSERK 716
Query: 533 TWIRVIQQSV--------------RTCPSREDFPLIETED-----------EAYLRRIKM 567
W +I ++ R PS PL+ + + +A RI
Sbjct: 717 NWCALITETAGSLKVPAPASRPKPRPSPSSTREPLLSSSENGNGGRETSPADARTERILS 776
Query: 568 EL------QQKDRALVELLREKVGLFAEMTHFQAEEDGGSGMALPTLPRGLFRSESLESP 621
+L + + LR+ + L + F AEED G+G P G+ L
Sbjct: 777 DLLPFCRPGPEGQLAATALRKVLSL--KQLLFPAEEDNGAGP--PRDGDGVPGGGPLSPA 832
Query: 622 RGERLLQDAIREVEGLKDLLVGPGVELLLTPREPALPLEPDSGGNTSP 669
R + + ++ + E +K L E L PL GGN+ P
Sbjct: 833 RTQEIQENLLSLEETMKQL------EELEEEFCRLRPLLSQLGGNSVP 874
>gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2
[Homo sapiens]
Length = 912
Score = 168 bits (425), Expect = 3e-41
Identities = 142/528 (26%), Positives = 245/528 (46%), Gaps = 65/528 (12%)
Query: 189 WSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELHLEPGVV 248
W V L K +K+Q+VI EL+ TE HVR L+++ LF M E L +
Sbjct: 398 WRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEEL 457
Query: 249 QGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCK 308
Q +FP +DEL ++H+ FL +L++RR+++ ++I +GD+L+++F G K
Sbjct: 458 QNIFPSLDELIEVHSLFLDRLMKRRQES-------GYLIEEIGDVLLARFDGAEGSWFQK 510
Query: 309 TYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQECILLVTQRITKYPL 368
S FCSR S AL+ K +D RF F+++ +R +++ I QR+TKYPL
Sbjct: 511 ISSRFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPL 570
Query: 369 LISRILQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQEIYNRMD--PRAQ 426
L+ I Q++ ER+ + A +E+L +V++ + +E RL++ R+D Q
Sbjct: 571 LLQSIGQNTEE-PTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQ 629
Query: 427 TPVPGKGPFGREELLRRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVFLQEKDQKYIF-- 484
+ P F ++ ++KL+H+G L W+ + +V VLL+ D+L+ LQ +D++ +
Sbjct: 630 SSDPMLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKS 689
Query: 485 ------PTLDKPS----VVSLQNLIVRDIANQEKGMFLISAAPPE--MYEVHTASRDDRS 532
PT D + V+ L + + R++A K +++ E +YE+ + +R
Sbjct: 690 HSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQTVSERK 749
Query: 533 TWIRVIQQSV--------------RTCPSREDFPLIETED-----------EAYLRRIKM 567
W +I ++ R PS PL+ + + +A RI
Sbjct: 750 NWCALITETAGSLKVPAPASRPKPRPSPSSTREPLLSSSENGNGGRETSPADARTERILS 809
Query: 568 EL------QQKDRALVELLREKVGLFAEMTHFQAEEDGGSGMALPTLPRGLFRSESLESP 621
+L + + LR+ + L + F AEED G+G P G+ L
Sbjct: 810 DLLPFCRPGPEGQLAATALRKVLSL--KQLLFPAEEDNGAGP--PRDGDGVPGGGPLSPA 865
Query: 622 RGERLLQDAIREVEGLKDLLVGPGVELLLTPREPALPLEPDSGGNTSP 669
R + + ++ + E +K L E L PL GGN+ P
Sbjct: 866 RTQEIQENLLSLEETMKQL------EELEEEFCRLRPLLSQLGGNSVP 907
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 87.8 bits (216), Expect = 4e-17
Identities = 93/356 (26%), Positives = 160/356 (44%), Gaps = 47/356 (13%)
Query: 207 KQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELHLEPGVVQGLFPCVDELSDIHTRFL 266
K+Q I+ELIQTE ++ L+++ +F+ M E L G + +F EL +T+ L
Sbjct: 1182 KRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTKLL 1241
Query: 267 SQLLERRRQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCKTYSEFCSRHSKALKLYKE 326
L R++ + +GD+L ++ S A Y FCS L ++
Sbjct: 1242 KALRVRKKTG-----GEKMPVQMIGDILAAELSHMQA------YIRFCSCQLNGAALLQQ 1290
Query: 327 LYARDKRFQQFIRKVTRPAVLKRHGVQECILLVTQRITKYPLLISRILQHSHGIEEERQD 386
D F++F++K+ K + +L QRIT+YPLLI IL+++ +
Sbjct: 1291 KTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSS 1350
Query: 387 LTTALGLVKELLSNVDEGIYQLEKGARLQEIYNRMDPRAQTPVPGKGPFGREELL----- 441
L AL +EL S V+EG+ + E RL+ I Q V +G E+L+
Sbjct: 1351 LKLALERAEELCSQVNEGVREKENSDRLEWI--------QAHVQCEGL--AEQLIFNSLT 1400
Query: 442 ----RRKLIHDGCLLWKTATGR------FKDVLVLLMTDVLVFLQEKDQKYIFPTLDK-- 489
RKL+H G L+KT + + F D L LL V F + +F +
Sbjct: 1401 NCLGPRKLLHSG-KLYKTKSNKELHGFLFNDFL-LLTYMVKQFAVSSGSEKLFSSKSNAQ 1458
Query: 490 ----PSVVSLQNLIVR--DIANQEKGMFLISAAPPEMYEVHTASRDDRSTWIRVIQ 539
+ + L ++V+ + ++ +F IS +Y + T + ++R+ W++ I+
Sbjct: 1459 FKMYKTPIFLNEVLVKLPTDPSSDEPVFHISHI-DRVYTLRTDNINERTAWVQKIK 1513
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 87.8 bits (216), Expect = 4e-17
Identities = 93/356 (26%), Positives = 160/356 (44%), Gaps = 47/356 (13%)
Query: 207 KQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELHLEPGVVQGLFPCVDELSDIHTRFL 266
K+Q I+ELIQTE ++ L+++ +F+ M E L G + +F EL +T+ L
Sbjct: 1209 KRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTKLL 1268
Query: 267 SQLLERRRQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCKTYSEFCSRHSKALKLYKE 326
L R++ + +GD+L ++ S A Y FCS L ++
Sbjct: 1269 KALRVRKKTG-----GEKMPVQMIGDILAAELSHMQA------YIRFCSCQLNGAALLQQ 1317
Query: 327 LYARDKRFQQFIRKVTRPAVLKRHGVQECILLVTQRITKYPLLISRILQHSHGIEEERQD 386
D F++F++K+ K + +L QRIT+YPLLI IL+++ +
Sbjct: 1318 KTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSS 1377
Query: 387 LTTALGLVKELLSNVDEGIYQLEKGARLQEIYNRMDPRAQTPVPGKGPFGREELL----- 441
L AL +EL S V+EG+ + E RL+ I Q V +G E+L+
Sbjct: 1378 LKLALERAEELCSQVNEGVREKENSDRLEWI--------QAHVQCEGL--AEQLIFNSLT 1427
Query: 442 ----RRKLIHDGCLLWKTATGR------FKDVLVLLMTDVLVFLQEKDQKYIFPTLDK-- 489
RKL+H G L+KT + + F D L LL V F + +F +
Sbjct: 1428 NCLGPRKLLHSG-KLYKTKSNKELHGFLFNDFL-LLTYMVKQFAVSSGSEKLFSSKSNAQ 1485
Query: 490 ----PSVVSLQNLIVR--DIANQEKGMFLISAAPPEMYEVHTASRDDRSTWIRVIQ 539
+ + L ++V+ + ++ +F IS +Y + T + ++R+ W++ I+
Sbjct: 1486 FKMYKTPIFLNEVLVKLPTDPSSDEPVFHISHI-DRVYTLRTDNINERTAWVQKIK 1540
Score = 33.5 bits (75), Expect = 0.98
Identities = 41/161 (25%), Positives = 67/161 (41%), Gaps = 26/161 (16%)
Query: 691 SDSSQRDRNGNQLR--SPQEEALQRLVNLYGLLHGL--------------QAAVAQQDTL 734
S S+ D NQL+ + + LQ L++L L+ L Q A+ Q +
Sbjct: 608 SKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLYKI 667
Query: 735 MEARFPEGPERREKLCRANSRDGEAGRAGAAPVAPEKQATELALLQRQHALLQEELRRCR 794
+ E +R +L + + EA R KQ E + L +EE + +
Sbjct: 668 KRDKLKEIERKRLELMQKKKLEDEAARKA-------KQGKENLWKEN---LRKEEEEKQK 717
Query: 795 RLGEERATEAGSLEARLRESEQARALLEREAEEARRQLAAL 835
RL EE+ E E R E +Q + +AEE +R+ A++
Sbjct: 718 RLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASV 758
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 81.3 bits (199), Expect = 4e-15
Identities = 59/211 (27%), Positives = 101/211 (47%), Gaps = 11/211 (5%)
Query: 207 KQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELHLEPGVVQGLFPCVDELSDIHTRFL 266
K+Q I+ELI TE ++V L+++T +F+ ++E L V +F EL + + L
Sbjct: 1237 KRQGYIHELIVTEENYVNDLQLVTEIFQKPLMESELLTEKEVAMIFVNWKELIMCNIKLL 1296
Query: 267 SQLLERRRQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCKTYSEFCSRHSKALKLYKE 326
L R++ S + +GD+L +Q + Y FCSR L ++
Sbjct: 1297 KALRVRKKM-----SGEKMPVKMIGDILSAQLPH------MQPYIRFCSRQLNGAALIQQ 1345
Query: 327 LYARDKRFQQFIRKVTRPAVLKRHGVQECILLVTQRITKYPLLISRILQHSHGIEEERQD 386
F++F++++ K + IL QR+T+YPL+I IL+++ +
Sbjct: 1346 KTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTPENHPDHSH 1405
Query: 387 LTTALGLVKELLSNVDEGIYQLEKGARLQEI 417
L AL +EL S V+EG+ + E RL+ I
Sbjct: 1406 LKHALEKAEELCSQVNEGVREKENSDRLEWI 1436
>gi|134133248 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]
Length = 725
Score = 77.0 bits (188), Expect = 8e-14
Identities = 86/392 (21%), Positives = 169/392 (43%), Gaps = 43/392 (10%)
Query: 161 ESLIDEEV--IYSELMSDFEMDEKDFAADSWSLAVDSSFLQQHKKEVMKQQDVIYELIQT 218
E +D +V + + +D ++ E+ + ++ A + L QH K + EL+ T
Sbjct: 110 EMALDSQVPKVTPQEEADSDVGEEPDSENTPQKADKDAGLAQHSGP-QKLLHIAQELLHT 168
Query: 219 ELHHVRTLKIMTRLFRTGMLEELHLEPGVVQGLFPCVDELSDIHTRFLSQLLERRRQALC 278
E +V+ L ++ ++F T L + + P V+ G+F + + H +FL L+ R
Sbjct: 169 EETYVKRLHLLDQVFCT-RLTDAGIPPEVIMGIFSNISSIHRFHGQFLLPELKTR----- 222
Query: 279 PGSTRNFVIH-RLGDLLISQFSGPSAEQMCKTYSEFCSRHSKALKLYKELYARDKRFQQF 337
T + + RLGD+L K Y E+ +A+ L R F+
Sbjct: 223 --ITEEWDTNPRLGDIL------QKLAPFLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDV 274
Query: 338 IRKVTRPAVLKRHGVQECILLVTQRITKYPLLISRILQHSHGIEEERQDLTTALGLVKEL 397
+ + + V +Q +L QR+ +Y LL+ L+ +R+D +L L+
Sbjct: 275 VHSIQKQEVCGNLTLQHHMLEPVQRVPRYELLLKDYLKRLPQDAPDRKDAERSLELISTA 334
Query: 398 LSNVDEGIYQLEKGARLQEIYNRMDPRAQTPVPGKGPFGREELLR--RKLIHDGCLLWKT 455
++ + I ++EK +L E+Y ++ G E+++ +LI +G + +
Sbjct: 335 ANHSNAAIRKVEKMHKLLEVYEQLG-------------GEEDIVNPANELIKEGQIQKLS 381
Query: 456 A-TGRFKDVLVLLMTDVLVF----LQEKDQKYIFPTLDKPSVVSLQNLIVRDIANQEKGM 510
A G +D + L ++++ L+ QK F +K + LQ V+DI
Sbjct: 382 AKNGTPQDRHLFLFNSMILYCVPKLRLMGQK--FSVREKMDISGLQ---VQDIVKPNTAH 436
Query: 511 FLISAAPPEMYEVHTASRDDRSTWIRVIQQSV 542
I E+ T + +++ WI++IQ ++
Sbjct: 437 TFIITGRKRSLELQTRTEEEKKEWIQIIQATI 468
>gi|134133265 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]
Length = 725
Score = 77.0 bits (188), Expect = 8e-14
Identities = 86/392 (21%), Positives = 169/392 (43%), Gaps = 43/392 (10%)
Query: 161 ESLIDEEV--IYSELMSDFEMDEKDFAADSWSLAVDSSFLQQHKKEVMKQQDVIYELIQT 218
E +D +V + + +D ++ E+ + ++ A + L QH K + EL+ T
Sbjct: 110 EMALDSQVPKVTPQEEADSDVGEEPDSENTPQKADKDAGLAQHSGP-QKLLHIAQELLHT 168
Query: 219 ELHHVRTLKIMTRLFRTGMLEELHLEPGVVQGLFPCVDELSDIHTRFLSQLLERRRQALC 278
E +V+ L ++ ++F T L + + P V+ G+F + + H +FL L+ R
Sbjct: 169 EETYVKRLHLLDQVFCT-RLTDAGIPPEVIMGIFSNISSIHRFHGQFLLPELKTR----- 222
Query: 279 PGSTRNFVIH-RLGDLLISQFSGPSAEQMCKTYSEFCSRHSKALKLYKELYARDKRFQQF 337
T + + RLGD+L K Y E+ +A+ L R F+
Sbjct: 223 --ITEEWDTNPRLGDIL------QKLAPFLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDV 274
Query: 338 IRKVTRPAVLKRHGVQECILLVTQRITKYPLLISRILQHSHGIEEERQDLTTALGLVKEL 397
+ + + V +Q +L QR+ +Y LL+ L+ +R+D +L L+
Sbjct: 275 VHSIQKQEVCGNLTLQHHMLEPVQRVPRYELLLKDYLKRLPQDAPDRKDAERSLELISTA 334
Query: 398 LSNVDEGIYQLEKGARLQEIYNRMDPRAQTPVPGKGPFGREELLR--RKLIHDGCLLWKT 455
++ + I ++EK +L E+Y ++ G E+++ +LI +G + +
Sbjct: 335 ANHSNAAIRKVEKMHKLLEVYEQLG-------------GEEDIVNPANELIKEGQIQKLS 381
Query: 456 A-TGRFKDVLVLLMTDVLVF----LQEKDQKYIFPTLDKPSVVSLQNLIVRDIANQEKGM 510
A G +D + L ++++ L+ QK F +K + LQ V+DI
Sbjct: 382 AKNGTPQDRHLFLFNSMILYCVPKLRLMGQK--FSVREKMDISGLQ---VQDIVKPNTAH 436
Query: 511 FLISAAPPEMYEVHTASRDDRSTWIRVIQQSV 542
I E+ T + +++ WI++IQ ++
Sbjct: 437 TFIITGRKRSLELQTRTEEEKKEWIQIIQATI 468
>gi|163792208 Rho guanine exchange factor 16 [Homo sapiens]
Length = 709
Score = 73.2 bits (178), Expect = 1e-12
Identities = 88/425 (20%), Positives = 177/425 (41%), Gaps = 53/425 (12%)
Query: 193 VDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELHLEPGVVQ--- 249
V+ L Q E K+Q+ ++E++ +E + +L I+ F L+ L V Q
Sbjct: 270 VELGILDQLSTEERKRQEAMFEILTSEFSYQHSLSILVEEF----LQSKELRATVTQMEH 325
Query: 250 -GLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCK 308
LF + ++ RF L +R + + ++ + D+L AE+
Sbjct: 326 HHLFSNILDVLGASQRFFEDLEQRHKAQV--------LVEDISDILEEH-----AEKHFH 372
Query: 309 TYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQECILLVTQRITKYPL 368
Y +CS + ++L + + F++ +R++ R + ++L QR+T+ PL
Sbjct: 373 PYIAYCSNEVYQQRTLQKLISSNAAFREALREIERRPACGGLPMLSFLILPMQRVTRLPL 432
Query: 369 LISRILQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQEIYNRMDPRAQTP 428
L+ + + G E + + AL + +L+ +EG +++E+ ++ ++ ++D
Sbjct: 433 LMDTLCLKTQGHSERYKAASRALKAISKLVRQCNEGAHRMERMEQMYTLHTQLDFSKVKS 492
Query: 429 VPGKGPFGREELLRRKLIHDGCLLWKTATGRFKDV------LVLLMTDVLVFLQEK-DQK 481
+P R L+ G L TG F+ + + L DVLV ++K ++
Sbjct: 493 LPLIS-------ASRWLLKRGELFLVEETGLFRKIASRPTCYLFLFNDVLVVTKKKSEES 545
Query: 482 YIFPTLDKPSVVSLQNLIVRDIANQEKGMFLISAAPP-------------EMYEVHTASR 528
Y+ + + + ++ + ++ G S P E + + S
Sbjct: 546 YMVQDYAQMNHIQVEKIEPSELPLPGGGNRSSSVPHPFQVTLLRNSEGRQEQLLLSSDSA 605
Query: 529 DDRSTWIRVIQQSVRT---CPSREDFPLIETEDEAYLRRI-KMELQQKDRALVELLREKV 584
DR+ WI + S R S+ D P +E + ++ ++ LQQ D LV L +E
Sbjct: 606 SDRARWIVALTHSERQWQGLSSKGDLPQVEITKAFFAKQADEVTLQQADVVLV-LQQEDG 664
Query: 585 GLFAE 589
L+ E
Sbjct: 665 WLYGE 669
>gi|38373682 pleckstrin homology domain containing family G member 5
isoform a [Homo sapiens]
Length = 1006
Score = 72.8 bits (177), Expect = 1e-12
Identities = 116/542 (21%), Positives = 213/542 (39%), Gaps = 109/542 (20%)
Query: 187 DSWSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLF--------RTGML 238
DSW +D ++ + QQ+ ++EL+ TE ++R L+++ LF +G+L
Sbjct: 318 DSWRELIDGH--EKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLL 375
Query: 239 EELHLEPGVVQGLFPCVDELSDIHTRF----LSQLLERRRQALCPGSTRNFVIHRLGDLL 294
E+ E LF + E++ +H R ++ +LE+ R R + + GD L
Sbjct: 376 CEVEAER-----LFSNIPEIAQLHRRLWASVMAPVLEKAR--------RTRALLQPGDFL 422
Query: 295 --ISQFSGPSAEQMCKTYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGV 352
F + K Y +C ++ + L + F+ +I + +R +
Sbjct: 423 KGFKMFGS-----LFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKL 477
Query: 353 QECILLVTQRITKYPLLISRILQHSHGIEEER--QDLTTALGLVKELLSNVDEGIYQLEK 410
+ + QR+TKYPLL+ +L+ + EE R + + +G V+ + +V+ + Q ++
Sbjct: 478 SDMLAKPHQRLTKYPLLLKSVLRKT---EEPRAKEAVVAMIGSVERFIHHVNACMRQRQE 534
Query: 411 GARLQEIYNRMDP---------------------RAQTPVPGKGPFGREELLRRKLIHDG 449
RL + +R+D P+PG P EE R+L+ +G
Sbjct: 535 RQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASP---EE--TRQLLLEG 589
Query: 450 CLLWKTATGRFKDVLVLLMTDVLVFLQEKDQKYIFPTLDKPSVVSLQNLIVRDIANQEKG 509
L K DV L TD+L+ + + + P +V ++ R++ ++ G
Sbjct: 590 SLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLV--DKIVCREL--RDPG 645
Query: 510 MFLI-----SAAPPEMYEVHTASRDDRSTWIRVI-------QQSVRTCPSREDFPLIETE 557
FL+ + Y + + W+ I QQ P PL E
Sbjct: 646 SFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLE 705
Query: 558 DEAYLRRIKMELQQKDRALVELLREKVGLFAEMTHFQAEEDGGSGMALPTLPRGLFRSES 617
+E + + E ++++ + E+ G S + PT+ R +S
Sbjct: 706 EEEDEQEEEEEEEEEEE-------------------EGEDSGTSAASSPTIMR-----KS 741
Query: 618 LESPRGERLLQDAIREVEGLKDLLVGPGVELLLTPREPALPLEPDSGGNTSPGVTANGEA 677
SP + D E L ++V PG + L +P + P S TS TA+
Sbjct: 742 SGSPDSQHCASDG--STETLAMVVVEPG-DTLSSPEFDSGPFSSQS-DETSLSTTASSAT 797
Query: 678 RT 679
T
Sbjct: 798 PT 799
>gi|111154084 pleckstrin homology domain containing family G member
5 isoform b [Homo sapiens]
Length = 1083
Score = 72.8 bits (177), Expect = 1e-12
Identities = 116/542 (21%), Positives = 213/542 (39%), Gaps = 109/542 (20%)
Query: 187 DSWSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLF--------RTGML 238
DSW +D ++ + QQ+ ++EL+ TE ++R L+++ LF +G+L
Sbjct: 395 DSWRELIDGH--EKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLL 452
Query: 239 EELHLEPGVVQGLFPCVDELSDIHTRF----LSQLLERRRQALCPGSTRNFVIHRLGDLL 294
E+ E LF + E++ +H R ++ +LE+ R R + + GD L
Sbjct: 453 CEVEAER-----LFSNIPEIAQLHRRLWASVMAPVLEKAR--------RTRALLQPGDFL 499
Query: 295 --ISQFSGPSAEQMCKTYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGV 352
F + K Y +C ++ + L + F+ +I + +R +
Sbjct: 500 KGFKMFGS-----LFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKL 554
Query: 353 QECILLVTQRITKYPLLISRILQHSHGIEEER--QDLTTALGLVKELLSNVDEGIYQLEK 410
+ + QR+TKYPLL+ +L+ + EE R + + +G V+ + +V+ + Q ++
Sbjct: 555 SDMLAKPHQRLTKYPLLLKSVLRKT---EEPRAKEAVVAMIGSVERFIHHVNACMRQRQE 611
Query: 411 GARLQEIYNRMDP---------------------RAQTPVPGKGPFGREELLRRKLIHDG 449
RL + +R+D P+PG P EE R+L+ +G
Sbjct: 612 RQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASP---EE--TRQLLLEG 666
Query: 450 CLLWKTATGRFKDVLVLLMTDVLVFLQEKDQKYIFPTLDKPSVVSLQNLIVRDIANQEKG 509
L K DV L TD+L+ + + + P +V ++ R++ ++ G
Sbjct: 667 SLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLV--DKIVCREL--RDPG 722
Query: 510 MFLI-----SAAPPEMYEVHTASRDDRSTWIRVI-------QQSVRTCPSREDFPLIETE 557
FL+ + Y + + W+ I QQ P PL E
Sbjct: 723 SFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLE 782
Query: 558 DEAYLRRIKMELQQKDRALVELLREKVGLFAEMTHFQAEEDGGSGMALPTLPRGLFRSES 617
+E + + E ++++ + E+ G S + PT+ R +S
Sbjct: 783 EEEDEQEEEEEEEEEEE-------------------EGEDSGTSAASSPTIMR-----KS 818
Query: 618 LESPRGERLLQDAIREVEGLKDLLVGPGVELLLTPREPALPLEPDSGGNTSPGVTANGEA 677
SP + D E L ++V PG + L +P + P S TS TA+
Sbjct: 819 SGSPDSQHCASDG--STETLAMVVVEPG-DTLSSPEFDSGPFSSQS-DETSLSTTASSAT 874
Query: 678 RT 679
T
Sbjct: 875 PT 876
>gi|111154088 pleckstrin homology domain containing family G member
5 isoform a [Homo sapiens]
Length = 1006
Score = 72.8 bits (177), Expect = 1e-12
Identities = 116/542 (21%), Positives = 213/542 (39%), Gaps = 109/542 (20%)
Query: 187 DSWSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLF--------RTGML 238
DSW +D ++ + QQ+ ++EL+ TE ++R L+++ LF +G+L
Sbjct: 318 DSWRELIDGH--EKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLL 375
Query: 239 EELHLEPGVVQGLFPCVDELSDIHTRF----LSQLLERRRQALCPGSTRNFVIHRLGDLL 294
E+ E LF + E++ +H R ++ +LE+ R R + + GD L
Sbjct: 376 CEVEAER-----LFSNIPEIAQLHRRLWASVMAPVLEKAR--------RTRALLQPGDFL 422
Query: 295 --ISQFSGPSAEQMCKTYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGV 352
F + K Y +C ++ + L + F+ +I + +R +
Sbjct: 423 KGFKMFGS-----LFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKL 477
Query: 353 QECILLVTQRITKYPLLISRILQHSHGIEEER--QDLTTALGLVKELLSNVDEGIYQLEK 410
+ + QR+TKYPLL+ +L+ + EE R + + +G V+ + +V+ + Q ++
Sbjct: 478 SDMLAKPHQRLTKYPLLLKSVLRKT---EEPRAKEAVVAMIGSVERFIHHVNACMRQRQE 534
Query: 411 GARLQEIYNRMDP---------------------RAQTPVPGKGPFGREELLRRKLIHDG 449
RL + +R+D P+PG P EE R+L+ +G
Sbjct: 535 RQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASP---EE--TRQLLLEG 589
Query: 450 CLLWKTATGRFKDVLVLLMTDVLVFLQEKDQKYIFPTLDKPSVVSLQNLIVRDIANQEKG 509
L K DV L TD+L+ + + + P +V ++ R++ ++ G
Sbjct: 590 SLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLV--DKIVCREL--RDPG 645
Query: 510 MFLI-----SAAPPEMYEVHTASRDDRSTWIRVI-------QQSVRTCPSREDFPLIETE 557
FL+ + Y + + W+ I QQ P PL E
Sbjct: 646 SFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLE 705
Query: 558 DEAYLRRIKMELQQKDRALVELLREKVGLFAEMTHFQAEEDGGSGMALPTLPRGLFRSES 617
+E + + E ++++ + E+ G S + PT+ R +S
Sbjct: 706 EEEDEQEEEEEEEEEEE-------------------EGEDSGTSAASSPTIMR-----KS 741
Query: 618 LESPRGERLLQDAIREVEGLKDLLVGPGVELLLTPREPALPLEPDSGGNTSPGVTANGEA 677
SP + D E L ++V PG + L +P + P S TS TA+
Sbjct: 742 SGSPDSQHCASDG--STETLAMVVVEPG-DTLSSPEFDSGPFSSQS-DETSLSTTASSAT 797
Query: 678 RT 679
T
Sbjct: 798 PT 799
>gi|111154080 pleckstrin homology domain containing family G member
5 isoform a [Homo sapiens]
Length = 1006
Score = 72.8 bits (177), Expect = 1e-12
Identities = 116/542 (21%), Positives = 213/542 (39%), Gaps = 109/542 (20%)
Query: 187 DSWSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLF--------RTGML 238
DSW +D ++ + QQ+ ++EL+ TE ++R L+++ LF +G+L
Sbjct: 318 DSWRELIDGH--EKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLL 375
Query: 239 EELHLEPGVVQGLFPCVDELSDIHTRF----LSQLLERRRQALCPGSTRNFVIHRLGDLL 294
E+ E LF + E++ +H R ++ +LE+ R R + + GD L
Sbjct: 376 CEVEAER-----LFSNIPEIAQLHRRLWASVMAPVLEKAR--------RTRALLQPGDFL 422
Query: 295 --ISQFSGPSAEQMCKTYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGV 352
F + K Y +C ++ + L + F+ +I + +R +
Sbjct: 423 KGFKMFGS-----LFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKL 477
Query: 353 QECILLVTQRITKYPLLISRILQHSHGIEEER--QDLTTALGLVKELLSNVDEGIYQLEK 410
+ + QR+TKYPLL+ +L+ + EE R + + +G V+ + +V+ + Q ++
Sbjct: 478 SDMLAKPHQRLTKYPLLLKSVLRKT---EEPRAKEAVVAMIGSVERFIHHVNACMRQRQE 534
Query: 411 GARLQEIYNRMDP---------------------RAQTPVPGKGPFGREELLRRKLIHDG 449
RL + +R+D P+PG P EE R+L+ +G
Sbjct: 535 RQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASP---EE--TRQLLLEG 589
Query: 450 CLLWKTATGRFKDVLVLLMTDVLVFLQEKDQKYIFPTLDKPSVVSLQNLIVRDIANQEKG 509
L K DV L TD+L+ + + + P +V ++ R++ ++ G
Sbjct: 590 SLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLV--DKIVCREL--RDPG 645
Query: 510 MFLI-----SAAPPEMYEVHTASRDDRSTWIRVI-------QQSVRTCPSREDFPLIETE 557
FL+ + Y + + W+ I QQ P PL E
Sbjct: 646 SFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLE 705
Query: 558 DEAYLRRIKMELQQKDRALVELLREKVGLFAEMTHFQAEEDGGSGMALPTLPRGLFRSES 617
+E + + E ++++ + E+ G S + PT+ R +S
Sbjct: 706 EEEDEQEEEEEEEEEEE-------------------EGEDSGTSAASSPTIMR-----KS 741
Query: 618 LESPRGERLLQDAIREVEGLKDLLVGPGVELLLTPREPALPLEPDSGGNTSPGVTANGEA 677
SP + D E L ++V PG + L +P + P S TS TA+
Sbjct: 742 SGSPDSQHCASDG--STETLAMVVVEPG-DTLSSPEFDSGPFSSQS-DETSLSTTASSAT 797
Query: 678 RT 679
T
Sbjct: 798 PT 799
>gi|111154078 pleckstrin homology domain containing family G member
5 isoform c [Homo sapiens]
Length = 1062
Score = 72.8 bits (177), Expect = 1e-12
Identities = 116/542 (21%), Positives = 213/542 (39%), Gaps = 109/542 (20%)
Query: 187 DSWSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLF--------RTGML 238
DSW +D ++ + QQ+ ++EL+ TE ++R L+++ LF +G+L
Sbjct: 374 DSWRELIDGH--EKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLL 431
Query: 239 EELHLEPGVVQGLFPCVDELSDIHTRF----LSQLLERRRQALCPGSTRNFVIHRLGDLL 294
E+ E LF + E++ +H R ++ +LE+ R R + + GD L
Sbjct: 432 CEVEAER-----LFSNIPEIAQLHRRLWASVMAPVLEKAR--------RTRALLQPGDFL 478
Query: 295 --ISQFSGPSAEQMCKTYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGV 352
F + K Y +C ++ + L + F+ +I + +R +
Sbjct: 479 KGFKMFGS-----LFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKL 533
Query: 353 QECILLVTQRITKYPLLISRILQHSHGIEEER--QDLTTALGLVKELLSNVDEGIYQLEK 410
+ + QR+TKYPLL+ +L+ + EE R + + +G V+ + +V+ + Q ++
Sbjct: 534 SDMLAKPHQRLTKYPLLLKSVLRKT---EEPRAKEAVVAMIGSVERFIHHVNACMRQRQE 590
Query: 411 GARLQEIYNRMDP---------------------RAQTPVPGKGPFGREELLRRKLIHDG 449
RL + +R+D P+PG P EE R+L+ +G
Sbjct: 591 RQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASP---EE--TRQLLLEG 645
Query: 450 CLLWKTATGRFKDVLVLLMTDVLVFLQEKDQKYIFPTLDKPSVVSLQNLIVRDIANQEKG 509
L K DV L TD+L+ + + + P +V ++ R++ ++ G
Sbjct: 646 SLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLV--DKIVCREL--RDPG 701
Query: 510 MFLI-----SAAPPEMYEVHTASRDDRSTWIRVI-------QQSVRTCPSREDFPLIETE 557
FL+ + Y + + W+ I QQ P PL E
Sbjct: 702 SFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLE 761
Query: 558 DEAYLRRIKMELQQKDRALVELLREKVGLFAEMTHFQAEEDGGSGMALPTLPRGLFRSES 617
+E + + E ++++ + E+ G S + PT+ R +S
Sbjct: 762 EEEDEQEEEEEEEEEEE-------------------EGEDSGTSAASSPTIMR-----KS 797
Query: 618 LESPRGERLLQDAIREVEGLKDLLVGPGVELLLTPREPALPLEPDSGGNTSPGVTANGEA 677
SP + D E L ++V PG + L +P + P S TS TA+
Sbjct: 798 SGSPDSQHCASDG--STETLAMVVVEPG-DTLSSPEFDSGPFSSQS-DETSLSTTASSAT 853
Query: 678 RT 679
T
Sbjct: 854 PT 855
>gi|222080070 pleckstrin homology domain-containing family G member
6 isoform b [Homo sapiens]
Length = 758
Score = 71.6 bits (174), Expect = 3e-12
Identities = 108/422 (25%), Positives = 176/422 (41%), Gaps = 78/422 (18%)
Query: 199 QQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELH---LEPGVVQGLFPCV 255
++ +E+ QQ+ ++EL+ TEL +VR LKIMT L G+L L + LF V
Sbjct: 121 KEMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNV 180
Query: 256 DELSDIHTRFLSQLL-ERRRQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCKTYSEFC 314
L H F ++L + G + + + G L Q P Y ++C
Sbjct: 181 PSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHP--------YVQYC 232
Query: 315 SRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQE-CILLVT--QRITKYPLLIS 371
R + + +E + F F++ + KR G Q C LL+ QRITKYPLL+
Sbjct: 233 LRVKQTMAYAREQQETNPLFHAFVQWCEKH---KRSGRQMLCDLLIKPHQRITKYPLLLH 289
Query: 372 RILQHSHGIEEERQDLTTAL-----GLVKELLSNVDEGIYQLEKGARLQEI--YNRMDPR 424
+L+ S E Q+ A+ ++ + V +G Q A Q I Y ++P
Sbjct: 290 AVLKRSP--EARAQEALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPYEVLEPP 347
Query: 425 AQTPVPGKGPFGREELL----------RRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVF 474
+ PF +L R+L+ +G + K DV + L +DVL
Sbjct: 348 SDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVL-- 405
Query: 475 LQEKDQKYIFPTLDKPSVV----SLQNLIVRDIANQEKGMFL-------ISAAPPEMYEV 523
L K Q+ DK V+ L+ L+ + + + + + +S+A V
Sbjct: 406 LVTKPQR----KADKAKVIRPPLMLEKLVCQPLRDPNSFLLIHLTEFQCVSSA----LLV 457
Query: 524 HTASRDDRSTWIRVIQQSVRTCPSREDFPLIETEDEAYLRRIKME--LQQKDRALVELLR 581
H S DR+ W+ QQ+ +A L+++K E +QQK R L+ L R
Sbjct: 458 HCPSPTDRAQWLEKTQQA-----------------QAALQKLKAEEYVQQK-RELLTLYR 499
Query: 582 EK 583
++
Sbjct: 500 DQ 501
>gi|222080068 pleckstrin homology domain-containing family G member
6 isoform a [Homo sapiens]
Length = 790
Score = 71.6 bits (174), Expect = 3e-12
Identities = 108/422 (25%), Positives = 176/422 (41%), Gaps = 78/422 (18%)
Query: 199 QQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELH---LEPGVVQGLFPCV 255
++ +E+ QQ+ ++EL+ TEL +VR LKIMT L G+L L + LF V
Sbjct: 153 KEMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNV 212
Query: 256 DELSDIHTRFLSQLL-ERRRQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCKTYSEFC 314
L H F ++L + G + + + G L Q P Y ++C
Sbjct: 213 PSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHP--------YVQYC 264
Query: 315 SRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQE-CILLVT--QRITKYPLLIS 371
R + + +E + F F++ + KR G Q C LL+ QRITKYPLL+
Sbjct: 265 LRVKQTMAYAREQQETNPLFHAFVQWCEKH---KRSGRQMLCDLLIKPHQRITKYPLLLH 321
Query: 372 RILQHSHGIEEERQDLTTAL-----GLVKELLSNVDEGIYQLEKGARLQEI--YNRMDPR 424
+L+ S E Q+ A+ ++ + V +G Q A Q I Y ++P
Sbjct: 322 AVLKRSP--EARAQEALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPYEVLEPP 379
Query: 425 AQTPVPGKGPFGREELL----------RRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVF 474
+ PF +L R+L+ +G + K DV + L +DVL
Sbjct: 380 SDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVL-- 437
Query: 475 LQEKDQKYIFPTLDKPSVV----SLQNLIVRDIANQEKGMFL-------ISAAPPEMYEV 523
L K Q+ DK V+ L+ L+ + + + + + +S+A V
Sbjct: 438 LVTKPQR----KADKAKVIRPPLMLEKLVCQPLRDPNSFLLIHLTEFQCVSSA----LLV 489
Query: 524 HTASRDDRSTWIRVIQQSVRTCPSREDFPLIETEDEAYLRRIKME--LQQKDRALVELLR 581
H S DR+ W+ QQ+ +A L+++K E +QQK R L+ L R
Sbjct: 490 HCPSPTDRAQWLEKTQQA-----------------QAALQKLKAEEYVQQK-RELLTLYR 531
Query: 582 EK 583
++
Sbjct: 532 DQ 533
>gi|222080066 pleckstrin homology domain-containing family G member
6 isoform a [Homo sapiens]
Length = 790
Score = 71.6 bits (174), Expect = 3e-12
Identities = 108/422 (25%), Positives = 176/422 (41%), Gaps = 78/422 (18%)
Query: 199 QQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELH---LEPGVVQGLFPCV 255
++ +E+ QQ+ ++EL+ TEL +VR LKIMT L G+L L + LF V
Sbjct: 153 KEMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNV 212
Query: 256 DELSDIHTRFLSQLL-ERRRQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCKTYSEFC 314
L H F ++L + G + + + G L Q P Y ++C
Sbjct: 213 PSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHP--------YVQYC 264
Query: 315 SRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQE-CILLVT--QRITKYPLLIS 371
R + + +E + F F++ + KR G Q C LL+ QRITKYPLL+
Sbjct: 265 LRVKQTMAYAREQQETNPLFHAFVQWCEKH---KRSGRQMLCDLLIKPHQRITKYPLLLH 321
Query: 372 RILQHSHGIEEERQDLTTAL-----GLVKELLSNVDEGIYQLEKGARLQEI--YNRMDPR 424
+L+ S E Q+ A+ ++ + V +G Q A Q I Y ++P
Sbjct: 322 AVLKRSP--EARAQEALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPYEVLEPP 379
Query: 425 AQTPVPGKGPFGREELL----------RRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVF 474
+ PF +L R+L+ +G + K DV + L +DVL
Sbjct: 380 SDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVL-- 437
Query: 475 LQEKDQKYIFPTLDKPSVV----SLQNLIVRDIANQEKGMFL-------ISAAPPEMYEV 523
L K Q+ DK V+ L+ L+ + + + + + +S+A V
Sbjct: 438 LVTKPQR----KADKAKVIRPPLMLEKLVCQPLRDPNSFLLIHLTEFQCVSSA----LLV 489
Query: 524 HTASRDDRSTWIRVIQQSVRTCPSREDFPLIETEDEAYLRRIKME--LQQKDRALVELLR 581
H S DR+ W+ QQ+ +A L+++K E +QQK R L+ L R
Sbjct: 490 HCPSPTDRAQWLEKTQQA-----------------QAALQKLKAEEYVQQK-RELLTLYR 531
Query: 582 EK 583
++
Sbjct: 532 DQ 533
>gi|190885497 Rho guanine nucleotide exchange factor 3 isoform 2
[Homo sapiens]
Length = 532
Score = 69.3 bits (168), Expect = 2e-11
Identities = 52/216 (24%), Positives = 102/216 (47%), Gaps = 19/216 (8%)
Query: 189 WSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELHLEPGVV 248
WS D Q + +K+Q+ I+EL Q E + LK+ + + ML+ + +
Sbjct: 110 WSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQEL 169
Query: 249 QGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCK 308
+F +D L +H LSQL + R+ GST + +G +L+
Sbjct: 170 NQIFGTLDSLIPLHEELLSQLRDVRKP---DGSTEH-----VGPILVGWL------PCLS 215
Query: 309 TYSEFCSRH--SKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQECILLVTQRITKY 366
+Y +CS +KAL +K+ +D R Q F+++ ++ + + + R+ KY
Sbjct: 216 SYDSYCSNQVAAKALLDHKK---QDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKY 272
Query: 367 PLLISRILQHSHGIEEERQDLTTALGLVKELLSNVD 402
PLL+ IL+H+ ++Q L A+ +++ +++ ++
Sbjct: 273 PLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEIN 308
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.132 0.375
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,977,694
Number of Sequences: 37866
Number of extensions: 1797071
Number of successful extensions: 8782
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 91
Number of HSP's successfully gapped in prelim test: 264
Number of HSP's that attempted gapping in prelim test: 7809
Number of HSP's gapped (non-prelim): 1013
length of query: 958
length of database: 18,247,518
effective HSP length: 112
effective length of query: 846
effective length of database: 14,006,526
effective search space: 11849520996
effective search space used: 11849520996
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.