BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|149192845 ubiquitin specific protease 24 [Homo sapiens] (2460 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|149192845 ubiquitin specific protease 24 [Homo sapiens] 4873 0.0 gi|145309309 ubiquitin specific protease 9, X-linked isoform 3 [... 960 0.0 gi|145309311 ubiquitin specific protease 9, X-linked isoform 4 [... 958 0.0 gi|74319833 ubiquitin specific protease 9, Y-linked [Homo sapiens] 942 0.0 gi|110347427 ubiquitin specific protease 34 [Homo sapiens] 248 4e-65 gi|71774197 ubiquitin specific protease 47 [Homo sapiens] 146 2e-34 gi|76257392 ubiquitin specific protease 48 isoform b [Homo sapiens] 143 2e-33 gi|52630449 ubiquitin specific protease 48 isoform a [Homo sapiens] 143 2e-33 gi|150378533 ubiquitin specific peptidase 7 [Homo sapiens] 119 5e-26 gi|41055953 ubiquitin thioesterase 40 [Homo sapiens] 115 7e-25 gi|122114651 ubiquitin specific peptidase 36 [Homo sapiens] 103 2e-21 gi|197116355 ubiquitin specific peptidase 46 isoform 2 [Homo sap... 101 8e-21 gi|31377709 ubiquitin specific peptidase 46 isoform 1 [Homo sapi... 101 8e-21 gi|32698815 ubiquitin thiolesterase 12 [Homo sapiens] 100 2e-20 gi|190684694 ubiquitin specific peptidase 8 [Homo sapiens] 97 1e-19 gi|190684692 ubiquitin specific peptidase 8 [Homo sapiens] 97 1e-19 gi|190684690 ubiquitin specific peptidase 8 [Homo sapiens] 97 1e-19 gi|79750944 ubiquitin specific peptidase 42 [Homo sapiens] 97 3e-19 gi|239757637 PREDICTED: ubiquitin specific peptidase 41 [Homo sa... 96 4e-19 gi|169215723 PREDICTED: ubiquitin specific peptidase 41 [Homo sa... 96 6e-19 gi|239746654 PREDICTED: ubiquitin specific protease 41 [Homo sap... 96 6e-19 gi|32313610 ubiquitin specific protease 18 [Homo sapiens] 96 6e-19 gi|239742276 PREDICTED: hypothetical protein XP_002342471 [Homo ... 92 5e-18 gi|153792150 deubiquitinating enzyme 3 [Homo sapiens] 92 8e-18 gi|239758075 PREDICTED: similar to deubiquitinating enzyme DUB1 ... 91 1e-17 gi|239742297 PREDICTED: hypothetical protein XP_002342480 [Homo ... 91 1e-17 gi|239742287 PREDICTED: hypothetical protein XP_002342475 [Homo ... 91 1e-17 gi|169217654 PREDICTED: similar to deubiquitinating enzyme DUB1 ... 91 2e-17 gi|239742282 PREDICTED: hypothetical protein XP_002342474 [Homo ... 91 2e-17 gi|157785653 ubiquitin specific peptidase 17 [Homo sapiens] 90 2e-17 >gi|149192845 ubiquitin specific protease 24 [Homo sapiens] Length = 2460 Score = 4873 bits (12639), Expect = 0.0 Identities = 2460/2460 (100%), Positives = 2460/2460 (100%) Query: 1 MTTLLCMGFSDPATIRKALRLAKNDINEAVALLTNERPGLDYGGYEPMDSGGLSESDENC 60 MTTLLCMGFSDPATIRKALRLAKNDINEAVALLTNERPGLDYGGYEPMDSGGLSESDENC Sbjct: 1 MTTLLCMGFSDPATIRKALRLAKNDINEAVALLTNERPGLDYGGYEPMDSGGLSESDENC 60 Query: 61 RRFMDRCMPEAFKKLLTSSAVHKWGTEIHEGIYNMLMLLIELVAERIKQDPIPTGLLGVL 120 RRFMDRCMPEAFKKLLTSSAVHKWGTEIHEGIYNMLMLLIELVAERIKQDPIPTGLLGVL Sbjct: 61 RRFMDRCMPEAFKKLLTSSAVHKWGTEIHEGIYNMLMLLIELVAERIKQDPIPTGLLGVL 120 Query: 121 TMAFNPDNEYHFKNRMKVSQRNWAEVFGEGNMFAVSPVSTFQKEPHGWVVDLVNKFGELG 180 TMAFNPDNEYHFKNRMKVSQRNWAEVFGEGNMFAVSPVSTFQKEPHGWVVDLVNKFGELG Sbjct: 121 TMAFNPDNEYHFKNRMKVSQRNWAEVFGEGNMFAVSPVSTFQKEPHGWVVDLVNKFGELG 180 Query: 181 GFAAIQAKLHSEDIELGAVSALIQPLGVCAEYLNSSVVQPMLDPVILTTIQDVRSVEEKD 240 GFAAIQAKLHSEDIELGAVSALIQPLGVCAEYLNSSVVQPMLDPVILTTIQDVRSVEEKD Sbjct: 181 GFAAIQAKLHSEDIELGAVSALIQPLGVCAEYLNSSVVQPMLDPVILTTIQDVRSVEEKD 240 Query: 241 LKDKRLVSIPELLSAVKLLCMRFQPDLVTIVDDLRLDILLRMLKSPHFSAKMNSLKEVTK 300 LKDKRLVSIPELLSAVKLLCMRFQPDLVTIVDDLRLDILLRMLKSPHFSAKMNSLKEVTK Sbjct: 241 LKDKRLVSIPELLSAVKLLCMRFQPDLVTIVDDLRLDILLRMLKSPHFSAKMNSLKEVTK 300 Query: 301 LIEDSTLSKSVKNAIDTDRLLDWLVENSVLSIALEGNIDQAQYCDRIKGIIELLGSKLSL 360 LIEDSTLSKSVKNAIDTDRLLDWLVENSVLSIALEGNIDQAQYCDRIKGIIELLGSKLSL Sbjct: 301 LIEDSTLSKSVKNAIDTDRLLDWLVENSVLSIALEGNIDQAQYCDRIKGIIELLGSKLSL 360 Query: 361 DELTKIWKIQSGQSSTVIENIHTIIAAAAVKFNSDQLNHLFVLIQKVLDVLWELAHLPTL 420 DELTKIWKIQSGQSSTVIENIHTIIAAAAVKFNSDQLNHLFVLIQKVLDVLWELAHLPTL Sbjct: 361 DELTKIWKIQSGQSSTVIENIHTIIAAAAVKFNSDQLNHLFVLIQKVLDVLWELAHLPTL 420 Query: 421 PSSLIQQALEEHLTILSDAYAVKEAIKRSYIIKCIEDIKRSSQLNNPQFVWVVPALRQLH 480 PSSLIQQALEEHLTILSDAYAVKEAIKRSYIIKCIEDIKRSSQLNNPQFVWVVPALRQLH Sbjct: 421 PSSLIQQALEEHLTILSDAYAVKEAIKRSYIIKCIEDIKRSSQLNNPQFVWVVPALRQLH 480 Query: 481 EITRSFIKQTYQKQDKSIIQDLKKNFEIVKLVTGSLIACHRLAAAVAGPGGLSGSTLVDG 540 EITRSFIKQTYQKQDKSIIQDLKKNFEIVKLVTGSLIACHRLAAAVAGPGGLSGSTLVDG Sbjct: 481 EITRSFIKQTYQKQDKSIIQDLKKNFEIVKLVTGSLIACHRLAAAVAGPGGLSGSTLVDG 540 Query: 541 RYTYREYLEAHLKFLAFFLQEATLYLGWNRAKEIWECLVTGQDVCELDREMCFEWFTKGQ 600 RYTYREYLEAHLKFLAFFLQEATLYLGWNRAKEIWECLVTGQDVCELDREMCFEWFTKGQ Sbjct: 541 RYTYREYLEAHLKFLAFFLQEATLYLGWNRAKEIWECLVTGQDVCELDREMCFEWFTKGQ 600 Query: 601 HDLESDVQQQLFKEKILKLESYEITMNGFNLFKTFFENVNLCDHRLKRQGAQLYVEKLEL 660 HDLESDVQQQLFKEKILKLESYEITMNGFNLFKTFFENVNLCDHRLKRQGAQLYVEKLEL Sbjct: 601 HDLESDVQQQLFKEKILKLESYEITMNGFNLFKTFFENVNLCDHRLKRQGAQLYVEKLEL 660 Query: 661 IGMDFIWKIAMESPDEEIANEAIQLIINYSYINLNPRLKKDSVSLHKKFIADCYTRLEAA 720 IGMDFIWKIAMESPDEEIANEAIQLIINYSYINLNPRLKKDSVSLHKKFIADCYTRLEAA Sbjct: 661 IGMDFIWKIAMESPDEEIANEAIQLIINYSYINLNPRLKKDSVSLHKKFIADCYTRLEAA 720 Query: 721 SSALGGPTLTHAVTRATKMLTATAMPTVATSVQSPYRSTKLVIIERLLLLAERYVITIED 780 SSALGGPTLTHAVTRATKMLTATAMPTVATSVQSPYRSTKLVIIERLLLLAERYVITIED Sbjct: 721 SSALGGPTLTHAVTRATKMLTATAMPTVATSVQSPYRSTKLVIIERLLLLAERYVITIED 780 Query: 781 FYSVPRTILPHGASFHGHLLTLNVTYESTKDTFTVEAHSNETIGSVRWKIAKQLCSPVDN 840 FYSVPRTILPHGASFHGHLLTLNVTYESTKDTFTVEAHSNETIGSVRWKIAKQLCSPVDN Sbjct: 781 FYSVPRTILPHGASFHGHLLTLNVTYESTKDTFTVEAHSNETIGSVRWKIAKQLCSPVDN 840 Query: 841 IQIFTNDSLLTVNKDQKLLHQLGFSDEQILTVKTSGSGTPSGSSADSSTSSSSSSSGVFS 900 IQIFTNDSLLTVNKDQKLLHQLGFSDEQILTVKTSGSGTPSGSSADSSTSSSSSSSGVFS Sbjct: 841 IQIFTNDSLLTVNKDQKLLHQLGFSDEQILTVKTSGSGTPSGSSADSSTSSSSSSSGVFS 900 Query: 901 SSYAMEQEKSLPGVVMALVCNVFDMLYQLANLEEPRITLRVRKLLLLIPTDPAIQEALDQ 960 SSYAMEQEKSLPGVVMALVCNVFDMLYQLANLEEPRITLRVRKLLLLIPTDPAIQEALDQ Sbjct: 901 SSYAMEQEKSLPGVVMALVCNVFDMLYQLANLEEPRITLRVRKLLLLIPTDPAIQEALDQ 960 Query: 961 LDSLGRKKTLLSESSSQSSKSPSLSSKQQHQPSASSILESLFRSFAPGMSTFRVLYNLEV 1020 LDSLGRKKTLLSESSSQSSKSPSLSSKQQHQPSASSILESLFRSFAPGMSTFRVLYNLEV Sbjct: 961 LDSLGRKKTLLSESSSQSSKSPSLSSKQQHQPSASSILESLFRSFAPGMSTFRVLYNLEV 1020 Query: 1021 LSSKLMPTADDDMARSCAKSFCENFLKAGGLSLVVNVMQRDSIPSEVDYETRQGVYSICL 1080 LSSKLMPTADDDMARSCAKSFCENFLKAGGLSLVVNVMQRDSIPSEVDYETRQGVYSICL Sbjct: 1021 LSSKLMPTADDDMARSCAKSFCENFLKAGGLSLVVNVMQRDSIPSEVDYETRQGVYSICL 1080 Query: 1081 QLARFLLVGQTMPTLLDEDLTKDGIEALSSRPFRNVSRQTSRQMSLCGTPEKSSYRQLSV 1140 QLARFLLVGQTMPTLLDEDLTKDGIEALSSRPFRNVSRQTSRQMSLCGTPEKSSYRQLSV Sbjct: 1081 QLARFLLVGQTMPTLLDEDLTKDGIEALSSRPFRNVSRQTSRQMSLCGTPEKSSYRQLSV 1140 Query: 1141 SDRSSIRVEEIIPAARVAIQTMEVSDFTSTVACFMRLSWAAAAGRLDLVGSSQPIKESNS 1200 SDRSSIRVEEIIPAARVAIQTMEVSDFTSTVACFMRLSWAAAAGRLDLVGSSQPIKESNS Sbjct: 1141 SDRSSIRVEEIIPAARVAIQTMEVSDFTSTVACFMRLSWAAAAGRLDLVGSSQPIKESNS 1200 Query: 1201 LCPAGIRNRLSSSGSNCSSGSEGEPVALHAGICVRQQSVSTKDSLIAGEALSLLVTCLQL 1260 LCPAGIRNRLSSSGSNCSSGSEGEPVALHAGICVRQQSVSTKDSLIAGEALSLLVTCLQL Sbjct: 1201 LCPAGIRNRLSSSGSNCSSGSEGEPVALHAGICVRQQSVSTKDSLIAGEALSLLVTCLQL 1260 Query: 1261 RSQQLASFYNLPCVADFIIDILLGSPSAEIRRVACDQLYTLSQTDTSAHPDVQKPNQFLL 1320 RSQQLASFYNLPCVADFIIDILLGSPSAEIRRVACDQLYTLSQTDTSAHPDVQKPNQFLL Sbjct: 1261 RSQQLASFYNLPCVADFIIDILLGSPSAEIRRVACDQLYTLSQTDTSAHPDVQKPNQFLL 1320 Query: 1321 GVILTAQLPLWSPTSIMRGVNQRLLSQCMEYFDLRCQLLDDLTTSEMEQLRISPATMLED 1380 GVILTAQLPLWSPTSIMRGVNQRLLSQCMEYFDLRCQLLDDLTTSEMEQLRISPATMLED Sbjct: 1321 GVILTAQLPLWSPTSIMRGVNQRLLSQCMEYFDLRCQLLDDLTTSEMEQLRISPATMLED 1380 Query: 1381 EITWLDNFEPNRTAECETSEADNILLAGHLRLIKTLLSLCGAEKEMLGSSLIKPLLDDFL 1440 EITWLDNFEPNRTAECETSEADNILLAGHLRLIKTLLSLCGAEKEMLGSSLIKPLLDDFL Sbjct: 1381 EITWLDNFEPNRTAECETSEADNILLAGHLRLIKTLLSLCGAEKEMLGSSLIKPLLDDFL 1440 Query: 1441 FRASRIILNSHSPAGSAAISQQDFHPKCSTANSRLAAYEVLVMLADSSPSNLQIIIKELL 1500 FRASRIILNSHSPAGSAAISQQDFHPKCSTANSRLAAYEVLVMLADSSPSNLQIIIKELL Sbjct: 1441 FRASRIILNSHSPAGSAAISQQDFHPKCSTANSRLAAYEVLVMLADSSPSNLQIIIKELL 1500 Query: 1501 SMHHQPDPALTKEFDYLPPVDSRSSSGFVGLRNGGATCYMNAVFQQLYMQPGLPESLLSV 1560 SMHHQPDPALTKEFDYLPPVDSRSSSGFVGLRNGGATCYMNAVFQQLYMQPGLPESLLSV Sbjct: 1501 SMHHQPDPALTKEFDYLPPVDSRSSSGFVGLRNGGATCYMNAVFQQLYMQPGLPESLLSV 1560 Query: 1561 DDDTDNPDDSVFYQVQSLFGHLMESKLQYYVPENFWKIFKMWNKELYVREQQDAYEFFTS 1620 DDDTDNPDDSVFYQVQSLFGHLMESKLQYYVPENFWKIFKMWNKELYVREQQDAYEFFTS Sbjct: 1561 DDDTDNPDDSVFYQVQSLFGHLMESKLQYYVPENFWKIFKMWNKELYVREQQDAYEFFTS 1620 Query: 1621 LIDQMDEYLKKMGRDQIFKNTFQGIYSDQKICKDCPHRYEREEAFMALNLGVTSCQSLEI 1680 LIDQMDEYLKKMGRDQIFKNTFQGIYSDQKICKDCPHRYEREEAFMALNLGVTSCQSLEI Sbjct: 1621 LIDQMDEYLKKMGRDQIFKNTFQGIYSDQKICKDCPHRYEREEAFMALNLGVTSCQSLEI 1680 Query: 1681 SLDQFVRGEVLEGSNAYYCEKCKEKRITVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKY 1740 SLDQFVRGEVLEGSNAYYCEKCKEKRITVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKY Sbjct: 1681 SLDQFVRGEVLEGSNAYYCEKCKEKRITVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKY 1740 Query: 1741 DEQIRFPWMLNMEPYTVSGMARQDSSSEVGENGRSVDQGGGGSPRKKVALTENYELVGVI 1800 DEQIRFPWMLNMEPYTVSGMARQDSSSEVGENGRSVDQGGGGSPRKKVALTENYELVGVI Sbjct: 1741 DEQIRFPWMLNMEPYTVSGMARQDSSSEVGENGRSVDQGGGGSPRKKVALTENYELVGVI 1800 Query: 1801 VHSGQAHAGHYYSFIKDRRGCGKGKWYKFNDTVIEEFDLNDETLEYECFGGEYRPKVYDQ 1860 VHSGQAHAGHYYSFIKDRRGCGKGKWYKFNDTVIEEFDLNDETLEYECFGGEYRPKVYDQ Sbjct: 1801 VHSGQAHAGHYYSFIKDRRGCGKGKWYKFNDTVIEEFDLNDETLEYECFGGEYRPKVYDQ 1860 Query: 1861 TNPYTDVRRRYWNAYMLFYQRVSDQNSPVLPKKSRVSVVRQEAEDLSLSAPSSPEISPQS 1920 TNPYTDVRRRYWNAYMLFYQRVSDQNSPVLPKKSRVSVVRQEAEDLSLSAPSSPEISPQS Sbjct: 1861 TNPYTDVRRRYWNAYMLFYQRVSDQNSPVLPKKSRVSVVRQEAEDLSLSAPSSPEISPQS 1920 Query: 1921 SPRPHRPNNDRLSILTKLVKKGEKKGLFVEKMPARIYQMVRDENLKFMKNRDVYSSDYFS 1980 SPRPHRPNNDRLSILTKLVKKGEKKGLFVEKMPARIYQMVRDENLKFMKNRDVYSSDYFS Sbjct: 1921 SPRPHRPNNDRLSILTKLVKKGEKKGLFVEKMPARIYQMVRDENLKFMKNRDVYSSDYFS 1980 Query: 1981 FVLSLASLNATKLKHPYYPCMAKVSLQLAIQFLFQTYLRTKKKLRVDTEEWIATIEALLS 2040 FVLSLASLNATKLKHPYYPCMAKVSLQLAIQFLFQTYLRTKKKLRVDTEEWIATIEALLS Sbjct: 1981 FVLSLASLNATKLKHPYYPCMAKVSLQLAIQFLFQTYLRTKKKLRVDTEEWIATIEALLS 2040 Query: 2041 KSFDACQWLVEYFISSEGRELIKIFLLECNVREVRVAVATILEKTLDSALFYQDKLKSLH 2100 KSFDACQWLVEYFISSEGRELIKIFLLECNVREVRVAVATILEKTLDSALFYQDKLKSLH Sbjct: 2041 KSFDACQWLVEYFISSEGRELIKIFLLECNVREVRVAVATILEKTLDSALFYQDKLKSLH 2100 Query: 2101 QLLEVLLALLDKDVPENCKNCAQYFFLFNTFVQKQGIRAGDLLLRHSALRHMISFLLGAS 2160 QLLEVLLALLDKDVPENCKNCAQYFFLFNTFVQKQGIRAGDLLLRHSALRHMISFLLGAS Sbjct: 2101 QLLEVLLALLDKDVPENCKNCAQYFFLFNTFVQKQGIRAGDLLLRHSALRHMISFLLGAS 2160 Query: 2161 RQNNQIRRWSSAQAREFGNLHNTVALLVLHSDVSSQRNVAPGIFKQRPPISIAPSSPLLP 2220 RQNNQIRRWSSAQAREFGNLHNTVALLVLHSDVSSQRNVAPGIFKQRPPISIAPSSPLLP Sbjct: 2161 RQNNQIRRWSSAQAREFGNLHNTVALLVLHSDVSSQRNVAPGIFKQRPPISIAPSSPLLP 2220 Query: 2221 LHEEVEALLFMSEGKPYLLEVMFALRELTGSLLALIEMVVYCCFCNEHFSFTMLHFIKNQ 2280 LHEEVEALLFMSEGKPYLLEVMFALRELTGSLLALIEMVVYCCFCNEHFSFTMLHFIKNQ Sbjct: 2221 LHEEVEALLFMSEGKPYLLEVMFALRELTGSLLALIEMVVYCCFCNEHFSFTMLHFIKNQ 2280 Query: 2281 LETAPPHELKNTFQLLHEILVIEDPIQVERVKFVFETENGLLALMHHSNHVDSSRCYQCV 2340 LETAPPHELKNTFQLLHEILVIEDPIQVERVKFVFETENGLLALMHHSNHVDSSRCYQCV Sbjct: 2281 LETAPPHELKNTFQLLHEILVIEDPIQVERVKFVFETENGLLALMHHSNHVDSSRCYQCV 2340 Query: 2341 KFLVTLAQKCPAAKEYFKENSHHWSWAVQWLQKKMSEHYWTPQSNVSNETSTGKTFQRTI 2400 KFLVTLAQKCPAAKEYFKENSHHWSWAVQWLQKKMSEHYWTPQSNVSNETSTGKTFQRTI Sbjct: 2341 KFLVTLAQKCPAAKEYFKENSHHWSWAVQWLQKKMSEHYWTPQSNVSNETSTGKTFQRTI 2400 Query: 2401 SAQDTLAYATALLNEKEQSGSSNGSESSPANENGDRHLQQGSESPMMIGELRSDLDDVDP 2460 SAQDTLAYATALLNEKEQSGSSNGSESSPANENGDRHLQQGSESPMMIGELRSDLDDVDP Sbjct: 2401 SAQDTLAYATALLNEKEQSGSSNGSESSPANENGDRHLQQGSESPMMIGELRSDLDDVDP 2460 >gi|145309309 ubiquitin specific protease 9, X-linked isoform 3 [Homo sapiens] Length = 2570 Score = 960 bits (2482), Expect = 0.0 Identities = 769/2593 (29%), Positives = 1228/2593 (47%), Gaps = 392/2593 (15%) Query: 52 GLSESDENCRRFMDRCMPEAFKKLLTSSAVHKWGTEIHEGIYNMLMLLIELVAERIKQDP 111 GL E C+RF + +F K+LT AV W EIH I N L+EL ++ QD Sbjct: 108 GLDVKSEACQRFFRDGLTISFTKILTDEAVSGWKFEIHRCIINNTHRLVELCVAKLSQDW 167 Query: 112 IPTGLLGVLTMAFNPDNEYHFKNRMKVSQRNWAEV-FGEGNMFAVSPVSTFQKEPHGWVV 170 P LL +L MA NP ++H N + + + V E +FA SP + P GW+V Sbjct: 168 FP--LLELLAMALNPHCKFHIYNGTRPCESVSSSVQLPEDELFARSP---DPRSPKGWLV 222 Query: 171 DLVNKFGELGGFAAIQAK-LHSEDIELGAVSALIQPLGVCAEYLNSSVVQPMLDPVILTT 229 DL+NKFG L GF + + ++ + + ++ALI+P G C E+L V+ P+I Sbjct: 223 DLLNKFGTLNGFQILHDRFINGSALNVQIIAALIKPFGQCYEFLTLHTVKKYFLPIIEMV 282 Query: 230 IQDVRSVEEKDLK-----DKRLVSIPELLSAVKLLCMRF--QPDLVTIVDDLRLDILLRM 282 Q + ++ +++LK + + ++ ++ ++K L R Q + V ++ RL ++LR+ Sbjct: 283 PQFLENLTDEELKKEAKNEAKNDALSMIIKSLKNLASRVPGQEETVKNLEIFRLKMILRL 342 Query: 283 LKSPHFSAKMNSLKEVTKLIEDSTL------SKSVKNAIDTDRLLDWLVENSVLSIALEG 336 L+ F+ KMN+L EV K+I + + + + +R+ +W+ +N++LSI L Sbjct: 343 LQISSFNGKMNALNEVNKVISSVSYYTHRHGNPEEEEWLTAERMAEWIQQNNILSIVLRD 402 Query: 337 NIDQAQYCDRIKGIIELL--GSKLSLDELTKIWKIQSGQSSTVIENIHTIIAAAAVKFNS 394 ++ Q QY ++++ I+ + L+L +L IW Q+G+ +++N+H ++A A F+ Sbjct: 403 SLHQPQYVEKLEKILRFVIKEKALTLQDLDNIWAAQAGKHEAIVKNVHDLLAKLAWDFSP 462 Query: 395 DQLNHLF--------------------------------VLIQKVLDVLWELAHLPTLPS 422 +QL+HLF V+ KVL++LW LAH +P Sbjct: 463 EQLDHLFDCFKASWTNASKKQREKLLELIRRLAEDDKDGVMAHKVLNLLWNLAHSDDVPV 522 Query: 423 SLIQQALEEHLTILSDAYAV-KEAIKRSYIIKCIEDIKRSSQLNNPQFVWVVPALRQLHE 481 ++ AL H+ IL + + ++ K +I + IE+++ + + WV+PAL+Q+ E Sbjct: 523 DIMDLALSAHIKILDYSCSQDRDTQKIQWIDRFIEELRTNDK-------WVIPALKQIRE 575 Query: 482 ITRSF------IKQTYQKQD----KSIIQDLKKNFEIVKLVTGSLIA-CHRLAAAVAGPG 530 I F + QT + +I L+ N +V LV +L + Sbjct: 576 ICSLFGEAPQNLSQTQRSPHVFYRHDLINQLQHNHALVTLVAENLATYMESMRLYARDHE 635 Query: 531 GLSGSTL-VDGRYTYREYLEAHLKFLAFFLQEATLYLGWNRAKEIWECLVTGQDVCELDR 589 T+ + RY++ + ++ L FL F L++ L+L +AK+IW+CL V DR Sbjct: 636 DYDPQTVRLGSRYSHVQEVQERLNFLRFLLKDGQLWLCAPQAKQIWKCLAENA-VYLCDR 694 Query: 590 EMCFEWFTK---GQHDLESDVQQQLFKEKILKLESYEITMNGFNLFKTFFENVNLCDHRL 646 E CF+W++K + DL+ D+ + F+ +L+L+ +T NG F+ FF+ VN + +L Sbjct: 695 EACFKWYSKLMGDEPDLDPDINKDFFESNVLQLDPSLLTENGMKCFERFFKAVNCREGKL 754 Query: 647 KRQGAQLYVEKLELIGMDFIWKIAMESPDEEIANEAIQLIINYSYINLNPRLKKDSVSLH 706 + ++ LELIG+D++W++ ++S D +IA+ AI L + Y NL PRL+ + V +H Sbjct: 755 VAKRRAYMMDDLELIGLDYLWRVVIQSND-DIASRAIDL-LKEIYTNLGPRLQVNQVVIH 812 Query: 707 KKFIADCYTRLEAASSALGGPTLTHAVTRATKMLTATAMPTVATSVQSPYRSTKLVIIER 766 + FI C+ RL+A+ L V K +V + Q R + R Sbjct: 813 EDFIQSCFDRLKASYDTL-------CVLDGDK-------DSVNCARQEAVR------MVR 852 Query: 767 LLLLAERYVITIEDFYSVPRTILPHGASFHGHLLTLNVTYES---TKDTFTVEAHSNETI 823 +L + Y+ + Y RTILP +F G L+ V + + D V +H+N+TI Sbjct: 853 VLTVLREYINECDSDYHEERTILPMSRAFRGKHLSFVVRFPNQGRQVDDLEVWSHTNDTI 912 Query: 824 GSVRWKIAKQLCSPV--DNIQIFTNDSLLTVNKDQKLLHQLGFSDEQILTVKTSGSGTPS 881 GSVR I ++ + V I++F L+ D+KL+ QL D+ ++T K + + Sbjct: 913 GSVRRCILNRIKANVAHTKIELFVGGELIDPADDRKLIGQLNLKDKSLITAKLTQISSNM 972 Query: 882 GSSADSSTSSSSSSSGVFSSSYA----MEQEKSLPGVVMALVCNVFDMLYQLA----NLE 933 SS DSS+ SS+ S G + Y+ E E LPGV+M+L L+Q+A +L Sbjct: 973 PSSPDSSSDSSTGSPGNHGNHYSDGPNPEVESCLPGVIMSLHPRYISFLWQVADLGSSLN 1032 Query: 934 EPRITLRVRKLLLLIPTDPAIQEALDQLDSLGRKKTLLSESSSQSSKSPSLSSKQQHQPS 993 P + R L+ L+P D E L R L +SS SPS Sbjct: 1033 MPPLRDGARVLMKLMPPDSTTIEKL-------RAICLDHAKLGESSLSPS---------- 1075 Query: 994 ASSILESLFRSFAPGMSTFRVLYNLEVLSSKLMPT----ADDDMARSCAKSFCENFLKAG 1049 L+SLF F P S +VLY EV+ + LMP ADD + F +FLK+G Sbjct: 1076 ----LDSLF--FGPSAS--QVLYLTEVVYALLMPAGAPLADD------SSDFQFHFLKSG 1121 Query: 1050 GLSLVVNVMQRDSIPSEVDYETRQGVYSICLQLARFLL--VGQTMPTLLDEDLTKDGIEA 1107 GL LV++++ R++ D ETR+G Y L++A+ LL +G + E + G+E Sbjct: 1122 GLPLVLSMLTRNNFLPNADMETRRGAYLNALKIAKLLLTAIGYGHVRAVAE-ACQPGVEG 1180 Query: 1108 LSSRPFRNVSRQTSRQMSLCGTPEKSSYRQLSVSDRSSIRVEEIIPAARVAIQTMEVSDF 1167 ++ P +++ T Q + + +S + S +R + A +++ + Sbjct: 1181 VN--PMTQINQVTHDQAVVLQSALQSI---PNPSSECMLRNVSVRLAQQISDEASRYMPD 1235 Query: 1168 TSTVACFMRLSWAAAAGRLDLVGSSQPIKESNSLCPAGIRNRLSSSGSNCSSGSEGEPVA 1227 + ++ WA+ G L LV S ++ ++G+E + Sbjct: 1236 ICVIRAIQKIIWASGCGSLQLVFSP--------------NEEITKIYEKTNAGNEPD--- 1278 Query: 1228 LHAGICVRQQSVSTKDSLIAGEALSLLVTCLQLRSQQLASFYNLPCVADFIIDILLGSPS 1287 +D + EAL ++ C L L + FIID+LL S Sbjct: 1279 -------------LEDEQVCCEALEVMTLCFALIPTALDALSKEKAWQTFIIDLLLHCHS 1325 Query: 1288 AEIRRVACDQLYTLSQTDTSAHPDVQKPNQFLLGVILTAQLPLWSPTSIMRGVNQRLLSQ 1347 +R+VA +Q + + H +P F + ++ T ++ + Sbjct: 1326 KTVRQVAQEQFFLMCTRCCMGH----RPLLFFITLLFT----------VLGSTARERAKH 1371 Query: 1348 CMEYFDLRCQLLDDLTTSEMEQLRISPATMLEDEITWLDNFEPNRTAECETSEADNILLA 1407 +YF L LL+ S + + +L +EI WL + ET + +L Sbjct: 1372 SGDYFTLLRHLLNYAYNSNINV--PNAEVLLNNEIDWLKRIRDDVKRTGETG-IEETILE 1428 Query: 1408 GHLRLIKTLLSLCGAEK------EMLGSSLIKPLLDDFLFRASRIIL----NSHSPAGSA 1457 GHL + K LL+ +EK E G++LIK L+DDF+F AS + L N PA A Sbjct: 1429 GHLGVTKELLAFQTSEKKFHIGCEKGGANLIKELIDDFIFPASNVYLQYMRNGELPAEQA 1488 Query: 1458 AISQQDFHPKCSTANSRLAAYEVLVMLADSSPSNLQIIIKELLSMHHQPDPALT----KE 1513 P C + + A +E+LV LA NL+ I+ L M++ T E Sbjct: 1489 I-------PVCGSPPTINAGFELLVALAVGCVRNLKQIVDSLTEMYYIGTAITTCEALTE 1541 Query: 1514 FDYLPPVDSRSSSGFVGLRNGGATCYMNAVFQQLYMQPGLPESLLS-------VDDDTD- 1565 ++YLPPV R GFVGL+N GATCYMN+V QQLYM P + +L+ VDDD Sbjct: 1542 WEYLPPVGPRPPKGFVGLKNAGATCYMNSVIQQLYMIPSIRNGILAIEGTGSDVDDDMSG 1601 Query: 1566 ----------NPDDSVF--------------------------YQVQSLFGHLMESKLQY 1589 +P D VF +Q +FGHL S+LQY Sbjct: 1602 DEKQDNESNVDPRDDVFGYPQQFEDKPALSKTEDRKEYNIGVLRHLQVIFGHLAASRLQY 1661 Query: 1590 YVPENFWKIFKMWNKELYVREQQDAYEFFTSLIDQMDEYLKKMGRDQIFKNTFQGIYSDQ 1649 YVP FWK F++W + + +REQ DA EFF SL+D +DE LK +G + G ++DQ Sbjct: 1662 YVPRGFWKQFRLWGEPVNLREQHDALEFFNSLVDSLDEALKALGHPAMLSKVLGGSFADQ 1721 Query: 1650 KICKDCPHRYEREEAFMALNLGVTSCQSLEISLDQFVRGEVLEGSNAYYCEKCKEKRITV 1709 KIC+ CPHRYE EE+F LN+ + + Q+L SL+Q+V+G++LEG+NAY+CEKC +K TV Sbjct: 1722 KICQGCPHRYECEESFTTLNVDIRNHQNLLDSLEQYVKGDLLEGANAYHCEKCNKKVDTV 1781 Query: 1710 KRTCIKSLPSVLVIHLMRFGFDWESGRSIKYDEQIRFPWMLNMEPYTVSGMARQDSSSEV 1769 KR IK LP VL I L RF +DWE +IK+++ FP L+MEPYTV+G+A+ + + V Sbjct: 1782 KRLLIKKLPPVLAIQLKRFDYDWERECAIKFNDYFEFPRELDMEPYTVAGVAKLEGDN-V 1840 Query: 1770 GENGRSVDQGGGGSPRKKVALTENYELVGVIVHSGQAHAGHYYSFIKDRRGCG--KGKWY 1827 + + Q + A + Y LVGV+VHSGQA GHYYS+I R G + +WY Sbjct: 1841 NPESQLIQQ--SEQSESETAGSTKYRLVGVLVHSGQASGGHYYSYIIQRNGGDGERNRWY 1898 Query: 1828 KFNDTVIEEFDL-NDETLEYECFGGEYRPKVYDQTNPYTDVRR--RYWNAYMLFYQRVS- 1883 KF+D + E + +DE ++ +CFGGEY +V+D RR R+WNAY+LFY+R+ Sbjct: 1899 KFDDGDVTECKMDDDEEMKNQCFGGEYMGEVFDHMMKRMSYRRQKRWWNAYILFYERMDT 1958 Query: 1884 -DQNSPVLPKKSRVSVVRQEAEDLSLSAPSSPEISPQSSPRPHRPNNDRLSILTKLVKKG 1942 DQ+ ++ S +++ + RPH+ I+ Sbjct: 1959 IDQDDELIRYISELAI----------------------TTRPHQ-------II------- 1982 Query: 1943 EKKGLFVEKMPARIYQMVRDENLKFMKNRDVYSSDYFSFVLSLASLNATKLKH------- 1995 MP+ I + VR +N++FM NR YS +YF F+ L + N L Sbjct: 1983 ---------MPSAIERSVRKQNVQFMHNRMQYSMEYFQFMKKLLTCNGVYLNPPPGQDHL 2033 Query: 1996 -PYYPCMAKVSLQLAIQFLFQTYLRTKKKLRVDTEEWIATIEALLSKSFDACQWLVEYFI 2054 P + +S+QLA +FLF T TKK +R +W + LL S + W + Sbjct: 2034 LPEAEEITMISIQLAARFLFTTGFHTKKVVRGSASDWYDALCILLRHSKNVRFWFAHNVL 2093 Query: 2055 SSEGRELIKIFLLECNVREVRVAVATILEKTLDSAL----------------FYQDKLKS 2098 + + +LLEC EVR A A ++ +L D L Sbjct: 2094 FNVSNRFSE-YLLECPSAEVRGAFAKLIVFIAHFSLQDGPCPSPFASPGPSSQAYDNLSL 2152 Query: 2099 LHQLLEVLLALLDKDVPENCKNCAQYFFLFNTFVQKQGIRAGDLLLRHS--ALRHMISFL 2156 LL +L LL ++V E+ ++ QYF LF + G+ LL+ S A ++S Sbjct: 2153 SDHLLRAVLNLLRREVSEHGRHLQQYFNLFVMYA-NLGVAEKTQLLKLSVPATFMLVSLD 2211 Query: 2157 LGASRQNNQIRRWSSAQAREFGNLHNTVALLVLHSDVSSQRNVAPGIFKQRPPI-----S 2211 G Q E G L++ V+ L+ +VSS+ + PP+ Sbjct: 2212 EGPGPP-------IKYQYAELGKLYSVVSQLIRCCNVSSRMQSS---INGNPPLPNPFGD 2261 Query: 2212 IAPSSPLLPLHEEVEALLFMSEGKPYLLEVMFALRELTGSLLALIEMVVYCCFCNEHFSF 2271 S P++P+ + V +LF+ Y+ +++ E + ++++ +CC+ N FS Sbjct: 2262 PNLSQPIMPIQQNVADILFVRTS--YVKKII----EDCSNSEETVKLLRFCCWENPQFSS 2315 Query: 2272 TMLHFIKNQLETAPPHELKNTFQLLHEILVIEDPIQVERV----KFVFETENGLLALMHH 2327 T+L + Q+ + +EL+ LL +IL+IED Q R+ K + + +GL + Sbjct: 2316 TVLSELLWQVAYSYTYELRPYLDLLLQILLIEDSWQTHRIHNALKGIPDDRDGLFDTIQR 2375 Query: 2328 SNHVDSSRCYQCVKFLVTLAQKCPAAKEYFKEN---SHHWSWAVQWLQKKMSE------- 2377 S + R YQC+K +V L CP A + + N W+WAV+WL ++ Sbjct: 2376 SKNHYQKRAYQCIKCMVALFSNCPVAYQILQGNGDLKRKWTWAVEWLGDELERRPYTGNP 2435 Query: 2378 ----HYWTPQSNVSNETSTGKTFQRTISAQDTLAYATALLNEKEQSGSS-NGSESSPANE 2432 + W+P SNETS G +R+ SA+ TLA A L E+ + +S E + E Sbjct: 2436 QYTYNNWSPPVQ-SNETSNGYFLERSHSARMTLAKACELCPEEVKKATSVQQIEMEESKE 2494 Query: 2433 NGDRHLQQGSESP 2445 D+ ESP Sbjct: 2495 PDDQDAPDEHESP 2507 >gi|145309311 ubiquitin specific protease 9, X-linked isoform 4 [Homo sapiens] Length = 2554 Score = 958 bits (2477), Expect = 0.0 Identities = 767/2581 (29%), Positives = 1223/2581 (47%), Gaps = 392/2581 (15%) Query: 52 GLSESDENCRRFMDRCMPEAFKKLLTSSAVHKWGTEIHEGIYNMLMLLIELVAERIKQDP 111 GL E C+RF + +F K+LT AV W EIH I N L+EL ++ QD Sbjct: 108 GLDVKSEACQRFFRDGLTISFTKILTDEAVSGWKFEIHRCIINNTHRLVELCVAKLSQDW 167 Query: 112 IPTGLLGVLTMAFNPDNEYHFKNRMKVSQRNWAEV-FGEGNMFAVSPVSTFQKEPHGWVV 170 P LL +L MA NP ++H N + + + V E +FA SP + P GW+V Sbjct: 168 FP--LLELLAMALNPHCKFHIYNGTRPCESVSSSVQLPEDELFARSP---DPRSPKGWLV 222 Query: 171 DLVNKFGELGGFAAIQAK-LHSEDIELGAVSALIQPLGVCAEYLNSSVVQPMLDPVILTT 229 DL+NKFG L GF + + ++ + + ++ALI+P G C E+L V+ P+I Sbjct: 223 DLLNKFGTLNGFQILHDRFINGSALNVQIIAALIKPFGQCYEFLTLHTVKKYFLPIIEMV 282 Query: 230 IQDVRSVEEKDLK-----DKRLVSIPELLSAVKLLCMRF--QPDLVTIVDDLRLDILLRM 282 Q + ++ +++LK + + ++ ++ ++K L R Q + V ++ RL ++LR+ Sbjct: 283 PQFLENLTDEELKKEAKNEAKNDALSMIIKSLKNLASRVPGQEETVKNLEIFRLKMILRL 342 Query: 283 LKSPHFSAKMNSLKEVTKLIEDSTL------SKSVKNAIDTDRLLDWLVENSVLSIALEG 336 L+ F+ KMN+L EV K+I + + + + +R+ +W+ +N++LSI L Sbjct: 343 LQISSFNGKMNALNEVNKVISSVSYYTHRHGNPEEEEWLTAERMAEWIQQNNILSIVLRD 402 Query: 337 NIDQAQYCDRIKGIIELL--GSKLSLDELTKIWKIQSGQSSTVIENIHTIIAAAAVKFNS 394 ++ Q QY ++++ I+ + L+L +L IW Q+G+ +++N+H ++A A F+ Sbjct: 403 SLHQPQYVEKLEKILRFVIKEKALTLQDLDNIWAAQAGKHEAIVKNVHDLLAKLAWDFSP 462 Query: 395 DQLNHLF--------------------------------VLIQKVLDVLWELAHLPTLPS 422 +QL+HLF V+ KVL++LW LAH +P Sbjct: 463 EQLDHLFDCFKASWTNASKKQREKLLELIRRLAEDDKDGVMAHKVLNLLWNLAHSDDVPV 522 Query: 423 SLIQQALEEHLTILSDAYAV-KEAIKRSYIIKCIEDIKRSSQLNNPQFVWVVPALRQLHE 481 ++ AL H+ IL + + ++ K +I + IE+++ + + WV+PAL+Q+ E Sbjct: 523 DIMDLALSAHIKILDYSCSQDRDTQKIQWIDRFIEELRTNDK-------WVIPALKQIRE 575 Query: 482 ITRSF------IKQTYQKQD----KSIIQDLKKNFEIVKLVTGSLIA-CHRLAAAVAGPG 530 I F + QT + +I L+ N +V LV +L + Sbjct: 576 ICSLFGEAPQNLSQTQRSPHVFYRHDLINQLQHNHALVTLVAENLATYMESMRLYARDHE 635 Query: 531 GLSGSTL-VDGRYTYREYLEAHLKFLAFFLQEATLYLGWNRAKEIWECLVTGQDVCELDR 589 T+ + RY++ + ++ L FL F L++ L+L +AK+IW+CL V DR Sbjct: 636 DYDPQTVRLGSRYSHVQEVQERLNFLRFLLKDGQLWLCAPQAKQIWKCLAENA-VYLCDR 694 Query: 590 EMCFEWFTK---GQHDLESDVQQQLFKEKILKLESYEITMNGFNLFKTFFENVNLCDHRL 646 E CF+W++K + DL+ D+ + F+ +L+L+ +T NG F+ FF+ VN + +L Sbjct: 695 EACFKWYSKLMGDEPDLDPDINKDFFESNVLQLDPSLLTENGMKCFERFFKAVNCREGKL 754 Query: 647 KRQGAQLYVEKLELIGMDFIWKIAMESPDEEIANEAIQLIINYSYINLNPRLKKDSVSLH 706 + ++ LELIG+D++W++ ++S D +IA+ AI L + Y NL PRL+ + V +H Sbjct: 755 VAKRRAYMMDDLELIGLDYLWRVVIQSND-DIASRAIDL-LKEIYTNLGPRLQVNQVVIH 812 Query: 707 KKFIADCYTRLEAASSALGGPTLTHAVTRATKMLTATAMPTVATSVQSPYRSTKLVIIER 766 + FI C+ RL+A+ L V K +V + Q R + R Sbjct: 813 EDFIQSCFDRLKASYDTL-------CVLDGDK-------DSVNCARQEAVR------MVR 852 Query: 767 LLLLAERYVITIEDFYSVPRTILPHGASFHGHLLTLNVTYES---TKDTFTVEAHSNETI 823 +L + Y+ + Y RTILP +F G L+ V + + D V +H+N+TI Sbjct: 853 VLTVLREYINECDSDYHEERTILPMSRAFRGKHLSFVVRFPNQGRQVDDLEVWSHTNDTI 912 Query: 824 GSVRWKIAKQLCSPV--DNIQIFTNDSLLTVNKDQKLLHQLGFSDEQILTVKTSGSGTPS 881 GSVR I ++ + V I++F L+ D+KL+ QL D+ ++T K + + Sbjct: 913 GSVRRCILNRIKANVAHTKIELFVGGELIDPADDRKLIGQLNLKDKSLITAKLTQISSNM 972 Query: 882 GSSADSSTSSSSSSSGVFSSSYA----MEQEKSLPGVVMALVCNVFDMLYQLA----NLE 933 SS DSS+ SS+ S G + Y+ E E LPGV+M+L L+Q+A +L Sbjct: 973 PSSPDSSSDSSTGSPGNHGNHYSDGPNPEVESCLPGVIMSLHPRYISFLWQVADLGSSLN 1032 Query: 934 EPRITLRVRKLLLLIPTDPAIQEALDQLDSLGRKKTLLSESSSQSSKSPSLSSKQQHQPS 993 P + R L+ L+P D E L R L +SS SPS Sbjct: 1033 MPPLRDGARVLMKLMPPDSTTIEKL-------RAICLDHAKLGESSLSPS---------- 1075 Query: 994 ASSILESLFRSFAPGMSTFRVLYNLEVLSSKLMPT----ADDDMARSCAKSFCENFLKAG 1049 L+SLF F P S +VLY EV+ + LMP ADD + F +FLK+G Sbjct: 1076 ----LDSLF--FGPSAS--QVLYLTEVVYALLMPAGAPLADD------SSDFQFHFLKSG 1121 Query: 1050 GLSLVVNVMQRDSIPSEVDYETRQGVYSICLQLARFLL--VGQTMPTLLDEDLTKDGIEA 1107 GL LV++++ R++ D ETR+G Y L++A+ LL +G + E + G+E Sbjct: 1122 GLPLVLSMLTRNNFLPNADMETRRGAYLNALKIAKLLLTAIGYGHVRAVAE-ACQPGVEG 1180 Query: 1108 LSSRPFRNVSRQTSRQMSLCGTPEKSSYRQLSVSDRSSIRVEEIIPAARVAIQTMEVSDF 1167 ++ P +++ T Q + + +S + S +R + A +++ + Sbjct: 1181 VN--PMTQINQVTHDQAVVLQSALQSI---PNPSSECMLRNVSVRLAQQISDEASRYMPD 1235 Query: 1168 TSTVACFMRLSWAAAAGRLDLVGSSQPIKESNSLCPAGIRNRLSSSGSNCSSGSEGEPVA 1227 + ++ WA+ G L LV S ++ ++G+E + Sbjct: 1236 ICVIRAIQKIIWASGCGSLQLVFSP--------------NEEITKIYEKTNAGNEPD--- 1278 Query: 1228 LHAGICVRQQSVSTKDSLIAGEALSLLVTCLQLRSQQLASFYNLPCVADFIIDILLGSPS 1287 +D + EAL ++ C L L + FIID+LL S Sbjct: 1279 -------------LEDEQVCCEALEVMTLCFALIPTALDALSKEKAWQTFIIDLLLHCHS 1325 Query: 1288 AEIRRVACDQLYTLSQTDTSAHPDVQKPNQFLLGVILTAQLPLWSPTSIMRGVNQRLLSQ 1347 +R+VA +Q + + H +P F + ++ T ++ + Sbjct: 1326 KTVRQVAQEQFFLMCTRCCMGH----RPLLFFITLLFT----------VLGSTARERAKH 1371 Query: 1348 CMEYFDLRCQLLDDLTTSEMEQLRISPATMLEDEITWLDNFEPNRTAECETSEADNILLA 1407 +YF L LL+ S + + +L +EI WL + ET + +L Sbjct: 1372 SGDYFTLLRHLLNYAYNSNINV--PNAEVLLNNEIDWLKRIRDDVKRTGETG-IEETILE 1428 Query: 1408 GHLRLIKTLLSLCGAEK------EMLGSSLIKPLLDDFLFRASRIIL----NSHSPAGSA 1457 GHL + K LL+ +EK E G++LIK L+DDF+F AS + L N PA A Sbjct: 1429 GHLGVTKELLAFQTSEKKFHIGCEKGGANLIKELIDDFIFPASNVYLQYMRNGELPAEQA 1488 Query: 1458 AISQQDFHPKCSTANSRLAAYEVLVMLADSSPSNLQIIIKELLSMHHQPDPALT----KE 1513 P C + + A +E+LV LA NL+ I+ L M++ T E Sbjct: 1489 I-------PVCGSPPTINAGFELLVALAVGCVRNLKQIVDSLTEMYYIGTAITTCEALTE 1541 Query: 1514 FDYLPPVDSRSSSGFVGLRNGGATCYMNAVFQQLYMQPGLPESLLS-------VDDDTD- 1565 ++YLPPV R GFVGL+N GATCYMN+V QQLYM P + +L+ VDDD Sbjct: 1542 WEYLPPVGPRPPKGFVGLKNAGATCYMNSVIQQLYMIPSIRNGILAIEGTGSDVDDDMSG 1601 Query: 1566 ----------NPDDSVF--------------------------YQVQSLFGHLMESKLQY 1589 +P D VF +Q +FGHL S+LQY Sbjct: 1602 DEKQDNESNVDPRDDVFGYPQQFEDKPALSKTEDRKEYNIGVLRHLQVIFGHLAASRLQY 1661 Query: 1590 YVPENFWKIFKMWNKELYVREQQDAYEFFTSLIDQMDEYLKKMGRDQIFKNTFQGIYSDQ 1649 YVP FWK F++W + + +REQ DA EFF SL+D +DE LK +G + G ++DQ Sbjct: 1662 YVPRGFWKQFRLWGEPVNLREQHDALEFFNSLVDSLDEALKALGHPAMLSKVLGGSFADQ 1721 Query: 1650 KICKDCPHRYEREEAFMALNLGVTSCQSLEISLDQFVRGEVLEGSNAYYCEKCKEKRITV 1709 KIC+ CPHRYE EE+F LN+ + + Q+L SL+Q+V+G++LEG+NAY+CEKC +K TV Sbjct: 1722 KICQGCPHRYECEESFTTLNVDIRNHQNLLDSLEQYVKGDLLEGANAYHCEKCNKKVDTV 1781 Query: 1710 KRTCIKSLPSVLVIHLMRFGFDWESGRSIKYDEQIRFPWMLNMEPYTVSGMARQDSSSEV 1769 KR IK LP VL I L RF +DWE +IK+++ FP L+MEPYTV+G+A+ + + V Sbjct: 1782 KRLLIKKLPPVLAIQLKRFDYDWERECAIKFNDYFEFPRELDMEPYTVAGVAKLEGDN-V 1840 Query: 1770 GENGRSVDQGGGGSPRKKVALTENYELVGVIVHSGQAHAGHYYSFIKDRRGCG--KGKWY 1827 + + Q + A + Y LVGV+VHSGQA GHYYS+I R G + +WY Sbjct: 1841 NPESQLIQQ--SEQSESETAGSTKYRLVGVLVHSGQASGGHYYSYIIQRNGGDGERNRWY 1898 Query: 1828 KFNDTVIEEFDL-NDETLEYECFGGEYRPKVYDQTNPYTDVRR--RYWNAYMLFYQRVS- 1883 KF+D + E + +DE ++ +CFGGEY +V+D RR R+WNAY+LFY+R+ Sbjct: 1899 KFDDGDVTECKMDDDEEMKNQCFGGEYMGEVFDHMMKRMSYRRQKRWWNAYILFYERMDT 1958 Query: 1884 -DQNSPVLPKKSRVSVVRQEAEDLSLSAPSSPEISPQSSPRPHRPNNDRLSILTKLVKKG 1942 DQ+ ++ S +++ + RPH+ I+ Sbjct: 1959 IDQDDELIRYISELAI----------------------TTRPHQ-------II------- 1982 Query: 1943 EKKGLFVEKMPARIYQMVRDENLKFMKNRDVYSSDYFSFVLSLASLNATKLKH------- 1995 MP+ I + VR +N++FM NR YS +YF F+ L + N L Sbjct: 1983 ---------MPSAIERSVRKQNVQFMHNRMQYSMEYFQFMKKLLTCNGVYLNPPPGQDHL 2033 Query: 1996 -PYYPCMAKVSLQLAIQFLFQTYLRTKKKLRVDTEEWIATIEALLSKSFDACQWLVEYFI 2054 P + +S+QLA +FLF T TKK +R +W + LL S + W + Sbjct: 2034 LPEAEEITMISIQLAARFLFTTGFHTKKVVRGSASDWYDALCILLRHSKNVRFWFAHNVL 2093 Query: 2055 SSEGRELIKIFLLECNVREVRVAVATILEKTLDSAL----------------FYQDKLKS 2098 + + +LLEC EVR A A ++ +L D L Sbjct: 2094 FNVSNRFSE-YLLECPSAEVRGAFAKLIVFIAHFSLQDGPCPSPFASPGPSSQAYDNLSL 2152 Query: 2099 LHQLLEVLLALLDKDVPENCKNCAQYFFLFNTFVQKQGIRAGDLLLRHS--ALRHMISFL 2156 LL +L LL ++V E+ ++ QYF LF + G+ LL+ S A ++S Sbjct: 2153 SDHLLRAVLNLLRREVSEHGRHLQQYFNLFVMYA-NLGVAEKTQLLKLSVPATFMLVSLD 2211 Query: 2157 LGASRQNNQIRRWSSAQAREFGNLHNTVALLVLHSDVSSQRNVAPGIFKQRPPI-----S 2211 G Q E G L++ V+ L+ +VSS+ + PP+ Sbjct: 2212 EGPGPP-------IKYQYAELGKLYSVVSQLIRCCNVSSRMQSS---INGNPPLPNPFGD 2261 Query: 2212 IAPSSPLLPLHEEVEALLFMSEGKPYLLEVMFALRELTGSLLALIEMVVYCCFCNEHFSF 2271 S P++P+ + V +LF+ Y+ +++ E + ++++ +CC+ N FS Sbjct: 2262 PNLSQPIMPIQQNVADILFVRTS--YVKKII----EDCSNSEETVKLLRFCCWENPQFSS 2315 Query: 2272 TMLHFIKNQLETAPPHELKNTFQLLHEILVIEDPIQVERV----KFVFETENGLLALMHH 2327 T+L + Q+ + +EL+ LL +IL+IED Q R+ K + + +GL + Sbjct: 2316 TVLSELLWQVAYSYTYELRPYLDLLLQILLIEDSWQTHRIHNALKGIPDDRDGLFDTIQR 2375 Query: 2328 SNHVDSSRCYQCVKFLVTLAQKCPAAKEYFKEN---SHHWSWAVQWLQKKMSE------- 2377 S + R YQC+K +V L CP A + + N W+WAV+WL ++ Sbjct: 2376 SKNHYQKRAYQCIKCMVALFSNCPVAYQILQGNGDLKRKWTWAVEWLGDELERRPYTGNP 2435 Query: 2378 ----HYWTPQSNVSNETSTGKTFQRTISAQDTLAYATALLNEKEQSGSSNGSE-SSPANE 2432 + W+P SNETS G +R+ SA+ TLA A L E+E E SP E Sbjct: 2436 QYTYNNWSPPVQ-SNETSNGYFLERSHSARMTLAKACELCPEEEPDDQDAPDEHESPPPE 2494 Query: 2433 N 2433 + Sbjct: 2495 D 2495 >gi|74319833 ubiquitin specific protease 9, Y-linked [Homo sapiens] Length = 2555 Score = 942 bits (2434), Expect = 0.0 Identities = 758/2574 (29%), Positives = 1202/2574 (46%), Gaps = 385/2574 (14%) Query: 52 GLSESDENCRRFMDRCMPEAFKKLLTSSAVHKWGTEIHEGIYNMLMLLIELVAERIKQDP 111 GL E C+RF + +F K+L AV W EIH I N L+EL ++ QD Sbjct: 109 GLDVKSEACQRFFRDGLTISFTKILMDEAVSGWKFEIHRCIINNTHRLVELCVAKLSQDW 168 Query: 112 IPTGLLGVLTMAFNPDNEYHFKNRMKVSQRNWAEV-FGEGNMFAVSPVSTFQKEPHGWVV 170 P LL +L MA NP ++H N + + + E +FA S + + P GW+V Sbjct: 169 FP--LLELLAMALNPHCKFHIYNGTRPCELISSNAQLPEDELFARS---SDPRSPKGWLV 223 Query: 171 DLVNKFGELGGFAAIQAKL-HSEDIELGAVSALIQPLGVCAEYLNSSVVQPMLDPVILTT 229 DL+NKFG L GF + + + + + ++ALI+P G C E+L+ ++ PVI Sbjct: 224 DLINKFGTLNGFQILHDRFFNGSALNIQIIAALIKPFGQCYEFLSQHTLKKYFIPVIEIV 283 Query: 230 IQDVRSVEEKDLK-----DKRLVSIPELLSAVKLLCMRF--QPDLVTIVDDLRLDILLRM 282 + ++ +++LK + + ++ ++ ++K L R Q + + ++ RL ++LR+ Sbjct: 284 PHLLENLTDEELKKEAKNEAKNDALSMIIKSLKNLASRISGQDETIKNLEIFRLKMILRL 343 Query: 283 LKSPHFSAKMNSLKEVTKLIEDSTL------SKSVKNAIDTDRLLDWLVENSVLSIALEG 336 L+ F+ KMN+L E+ K+I + + + + +R+ +W+ +N++LSI L+ Sbjct: 344 LQISSFNGKMNALNEINKVISSVSYYTHRHSNPEEEEWLTAERMAEWIQQNNILSIVLQD 403 Query: 337 NIDQAQYCDRIKGIIELLGSK--LSLDELTKIWKIQSGQSSTVIENIHTIIAAAAVKFNS 394 ++ Q QY ++++ I+ + + L+L +L IW Q+G+ +++N+H ++A A F+ Sbjct: 404 SLHQPQYVEKLEKILRFVIKEKALTLQDLDNIWAAQAGKHEAIVKNVHDLLAKLAWDFSP 463 Query: 395 DQLNHLF--------------------------------VLIQKVLDVLWELAHLPTLPS 422 QL+HLF V+ KVL++LW LA +P Sbjct: 464 GQLDHLFDCFKASWTNASKKQREKLLELIRRLAEDDKDGVMAHKVLNLLWNLAQSDDVPV 523 Query: 423 SLIQQALEEHLTILSDAYAV-KEAIKRSYIIKCIEDIKRSSQLNNPQFVWVVPALRQLHE 481 ++ AL H+ IL + + ++A K +I IE+++ + + WV+PAL+Q+ E Sbjct: 524 DIMDLALSAHIKILDYSCSQDRDAQKIQWIDHFIEELRTNDK-------WVIPALKQIRE 576 Query: 482 ITRSF------IKQTYQKQD----KSIIQDLKKNFEIVKLVTGSLIACHRLAAAVAGPGG 531 I F + QT + +I L++N +V LV +L AG Sbjct: 577 ICSLFGEASQNLSQTQRSPHIFYRHDLINQLQQNHALVTLVAENLATYMNSIRLYAGDHE 636 Query: 532 LSGSTLV--DGRYTYREYLEAHLKFLAFFLQEATLYLGWNRAKEIWECLVTGQDVCELDR 589 V RY++ + ++ L FL F L++ L+L +AK+IW+CL V DR Sbjct: 637 DYDPQTVRLGSRYSHVQEVQERLNFLRFLLKDGQLWLCAPQAKQIWKCLAENA-VYLCDR 695 Query: 590 EMCFEWFTK---GQHDLESDVQQQLFKEKILKLESYEITMNGFNLFKTFFENVNLCDHRL 646 E CF+W++K + DL+ D+ + F+ +L+L+ +T NG F+ FF+ VN + +L Sbjct: 696 EACFKWYSKLMGDEPDLDPDINKDFFESNVLQLDPSLLTENGMKCFERFFKAVNCRERKL 755 Query: 647 KRQGAQLYVEKLELIGMDFIWKIAMESPDEEIANEAIQLIINYSYINLNPRLKKDSVSLH 706 + ++ LELIG+D++W++ ++S DE IAN AI L+ Y NL PRLK + V +H Sbjct: 756 IAKRRSYMMDDLELIGLDYLWRVVIQSSDE-IANRAIDLLKEI-YTNLGPRLKANQVVIH 813 Query: 707 KKFIADCYTRLEAASSALGGPTLTHAVTRATKMLTATAMPTVATSVQSPYRSTKLVIIER 766 + FI C+ RL+A+ L V K A V R Sbjct: 814 EDFIQSCFDRLKASYDTL-------CVFDGDKNSINCARQEAIRMV-------------R 853 Query: 767 LLLLAERYVITIEDFYSVPRTILPHGASFHGHLLTLNVTYESTK---DTFTVEAHSNETI 823 +L + + Y+ + Y R ILP +F G L+L V + + D + +H+N+TI Sbjct: 854 VLTVIKEYINECDSDYHKERMILPMSRAFRGKHLSLIVRFPNQGRQVDELDIWSHTNDTI 913 Query: 824 GSVRWKIAKQLCSPVDN--IQIFTNDSLLTVNKDQKLLHQLGFSDEQILTVKTSGSGTPS 881 GSVR I ++ + V + I++F L+ D+KL+ QL D+ ++T K + Sbjct: 914 GSVRRCIVNRIKANVAHKKIELFVGGELIDSEDDRKLIGQLNLKDKSLITAKLTQINFNM 973 Query: 882 GSSADSSTSSSSSSSGVFSSSYA----MEQEKSLPGVVMALVCNVFDMLYQLA----NLE 933 SS DSS+ SS++S G + Y +E E LPGV+M++ L+Q+A NL Sbjct: 974 PSSPDSSSDSSTASPGNHRNHYNDGPNLEVESCLPGVIMSVHPRYISFLWQVADLGSNLN 1033 Query: 934 EPRITLRVRKLLLLIPTDPAIQEALDQLDSLGRKKTLLSESSSQSSKSPSLSSKQQHQPS 993 P + R L+ L+P D E L ++ L + + Sbjct: 1034 MPPLRDGARVLMKLMPPDRTAVEKL---------------------RAVCLDHAKLGEGK 1072 Query: 994 ASSILESLFRSFAPGMSTFRVLYNLEVLSSKLMPTADDDMARSCAKSFCENFLKAGGLSL 1053 S L+SLF F P S +VLY EV+ + LMP + F +FLK+GGL L Sbjct: 1073 LSPPLDSLF--FGPSAS--QVLYLTEVVYALLMPAGVP--LTDGSSDFQVHFLKSGGLPL 1126 Query: 1054 VVNVMQRDSIPSEVDYETRQGVYSICLQLARFLLV----GQTMPTLLDEDLTKDGIEALS 1109 V++++ R++ D ETR+G Y L++A+ LL G DG + ++ Sbjct: 1127 VLSMLIRNNFLPNTDMETRRGAYLNALKIAKLLLTAIGYGHVRAVAEACQPVVDGTDPIT 1186 Query: 1110 SRPFRNVSRQTSRQMSLCGTPEKSSYRQLSVSDRSSIRVEEIIPAARVAIQTMEVSDFTS 1169 + Q +L P SS +R E I+ A ++ + Sbjct: 1187 QINQVTHDQAVVLQSALQSIPNPSS--------ECVLRNESILLAQEISNEASRYMPDIC 1238 Query: 1170 TVACFMRLSWAAAAGRLDLVGSSQPIKESNSLCPAGIRNRLSSSGSNCSSGSEGEPVALH 1229 + ++ WA+A G L LV S P +E + +++++GSN Sbjct: 1239 VIRAIQKIIWASACGALGLVFS--PNEEITKIY------QMTTNGSN------------- 1277 Query: 1230 AGICVRQQSVSTKDSLIAGEALSLLVTCLQLRSQQLASFYNLPCVADFIIDILLGSPSAE 1289 + +D + EAL ++ C L L + FIID+LL PS Sbjct: 1278 --------KLEVEDEQVCCEALEVMTLCFALLPTALDALSKEKAWQTFIIDLLLHCPSKT 1329 Query: 1290 IRRVACDQLYTLSQTDTSAHPDVQKPNQFLLGVILTAQLPLWSPTSIMRGVNQRLLSQCM 1349 +R++A +Q + + H +P F + ++ T I+ + Sbjct: 1330 VRQLAQEQFFLMCTRCCMGH----RPLLFFITLLFT----------ILGSTAREKGKYSG 1375 Query: 1350 EYFDLRCQLLDDLTTSEMEQLRISPATMLEDEITWLDNFEPNRTAECETSEADNILLAGH 1409 +YF L LL+ + +L EI WL N ET + IL GH Sbjct: 1376 DYFTLLRHLLNYAYNGNINIPNAE--VLLVSEIDWLKRIRDNVKNTGETGVEEPIL-EGH 1432 Query: 1410 LRLIKTLLSLCGAEK------EMLGSSLIKPLLDDFLFRASRIILNSHSPAGSAAISQQD 1463 L + K LL+ +EK E G++LIK L+DDF+F AS++ L S + + Sbjct: 1433 LGVTKELLAFQTSEKKYHFGCEKGGANLIKELIDDFIFPASKVYLQY---LRSGELPAEQ 1489 Query: 1464 FHPKCSTANSRLAAYEVLVMLADSSPSNLQIIIKELLSMHHQPDPALT----KEFDYLPP 1519 P CS+ + A +E+LV LA NL+ I+ L M++ T E++YLPP Sbjct: 1490 AIPVCSSPVTINAGFELLVALAIGCVRNLKQIVDCLTEMYYMGTAITTCEALTEWEYLPP 1549 Query: 1520 VDSRSSSGFVGLRNGGATCYMNAVFQQLYMQPGLPESLLSVD------------------ 1561 V R GFVGL+N GATCYMN+V QQLYM P + S+L+++ Sbjct: 1550 VGPRPPKGFVGLKNAGATCYMNSVIQQLYMIPSIRNSILAIEGTGSDLHDDMFGDEKQDS 1609 Query: 1562 DDTDNPDDSVF--------------------------YQVQSLFGHLMESKLQYYVPENF 1595 + +P D VF +Q +FGHL S+LQYYVP F Sbjct: 1610 ESNVDPRDDVFGYPHQFEDKPALSKTEDRKEYNIGVLRHLQVIFGHLAASQLQYYVPRGF 1669 Query: 1596 WKIFKMWNKELYVREQQDAYEFFTSLIDQMDEYLKKMGRDQIFKNTFQGIYSDQKICKDC 1655 WK F++W + + +REQ DA EFF SL+D +DE LK +G I G ++DQKIC+ C Sbjct: 1670 WKQFRLWGEPVNLREQHDALEFFNSLVDSLDEALKALGHPAILSKVLGGSFADQKICQGC 1729 Query: 1656 PHRYEREEAFMALNLGVTSCQSLEISLDQFVRGEVLEGSNAYYCEKCKEKRITVKRTCIK 1715 PHRYE EE+F LN+ + + Q+L SL+Q+++G++LEG+NAY+CEKC +K TVKR IK Sbjct: 1730 PHRYECEESFTTLNVDIRNHQNLLDSLEQYIKGDLLEGANAYHCEKCDKKVDTVKRLLIK 1789 Query: 1716 SLPSVLVIHLMRFGFDWESGRSIKYDEQIRFPWMLNMEPYTVSGMA---RQDSSSE---V 1769 LP VL I L RF +DWE +IK+++ FP L+M PYTV+G+A R + +SE + Sbjct: 1790 KLPRVLAIQLKRFDYDWERECAIKFNDYFEFPRELDMGPYTVAGVANLERDNVNSENELI 1849 Query: 1770 GENGRSVDQGGGGSPRKKVALTENYELVGVIVHSGQAHAGHYYSFIKDRRGCG--KGKWY 1827 + +S ++ GG+ Y LVGV+VHSGQA GHYYS+I R G WY Sbjct: 1850 EQKEQSDNETAGGT---------KYRLVGVLVHSGQASGGHYYSYIIQRNGKDDQTDHWY 1900 Query: 1828 KFNDTVIEEFDL-NDETLEYECFGGEYRPKVYDQTNPYTDVRR--RYWNAYMLFYQRVSD 1884 KF+D + E + +DE ++ +CFGGEY +V+D RR R+WNAY+LFY+ Sbjct: 1901 KFDDGDVTECKMDDDEEMKNQCFGGEYMGEVFDHMMKRMSYRRQKRWWNAYILFYE---- 1956 Query: 1885 QNSPVLPKKSRVSVVRQEAEDLSLSAPSSPEISPQSSPRPHRPNNDRLSILTKLVKKGEK 1944 ++ ++ ++ E + IS + RPH+ Sbjct: 1957 ----------QMDMIDEDDEMIRY-------ISELTIARPHQ------------------ 1981 Query: 1945 KGLFVEKMPARIYQMVRDENLKFMKNRDVYSSDYFSFVLSLASLNATKLKH--------P 1996 + PA I + VR +N+KFM NR YS +YF FV L + N L P Sbjct: 1982 ----IIMSPA-IERSVRKQNVKFMHNRLQYSLEYFQFVKKLLTCNGVYLNPAPGQDYLLP 2036 Query: 1997 YYPCMAKVSLQLAIQFLFQTYLRTKKKLRVDTEEWIATIEALLSKSFDACQWLVEYFISS 2056 + +S+QLA +FLF T TKK +R +W + LL S + W + + Sbjct: 2037 EAEEITMISIQLAARFLFTTGFHTKKIVRGPASDWYDALCVLLRHSKNVRFWFTHNVLFN 2096 Query: 2057 EGRELIKIFLLECNVREVRVAVATILEKTLDSAL--------FYQ--------DKLKSLH 2100 + +LLEC EVR A A ++ +L F D L Sbjct: 2097 VSNRFSE-YLLECPSAEVRGAFAKLIVFIAHFSLQDGSCPSPFASPGPSSQACDNLSLSD 2155 Query: 2101 QLLEVLLALLDKDVPENCKNCAQYFFLFNTFVQKQGIRAGDLL-LRHSALRHMISFLLGA 2159 LL L LL ++V E+ + QYF LF + LL L A ++S G Sbjct: 2156 HLLRATLNLLRREVSEHGHHLQQYFNLFVMYANLGVAEKTQLLKLNVPATFMLVSLDEGP 2215 Query: 2160 SRQNNQIRRWSSAQAREFGNLHNTVALLVLHSDVSSQRNVAPGIFKQRPPI-----SIAP 2214 Q E G L++ V+ L+ +VSS + PP+ + Sbjct: 2216 GPP-------IKYQYAELGKLYSVVSQLIRCCNVSSTMQSS---INGNPPLPNPFGDLNL 2265 Query: 2215 SSPLLPLHEEVEALLFMSEGKPYLLEVMFALRELTGSLLALIEMVVYCCFCNEHFSFTML 2274 S P++P+ + V +LF+ Y+ +++ E + I+++ +C + N FS T+L Sbjct: 2266 SQPIMPIQQNVLDILFVRTS--YVKKII----EDCSNSEDTIKLLRFCSWENPQFSSTVL 2319 Query: 2275 HFIKNQLETAPPHELKNTFQLLHEILVIEDPIQVERV----KFVFETENGLLALMHHSNH 2330 + Q+ + +EL+ LL +IL+IED Q R+ K + + +GL + S + Sbjct: 2320 SELLWQVAYSYTYELRPYLDLLFQILLIEDSWQTHRIHNALKGIPDDRDGLFDTIQRSKN 2379 Query: 2331 VDSSRCYQCVKFLVTLAQKCPAAKEYFKEN---SHHWSWAVQWLQKKM-----------S 2376 R YQC+K +V L CP A + + N W+WAV+WL ++ S Sbjct: 2380 HYQKRAYQCIKCMVALFSSCPVAYQILQGNGDLKRKWTWAVEWLGDELERRPYTGNPQYS 2439 Query: 2377 EHYWTPQSNVSNETSTGKTFQRTISAQDTLAYATALLNEKEQSGSSNGSESSPA 2430 + W+P SNET+ G +R+ SA+ TLA A L E+E E P+ Sbjct: 2440 YNNWSPPVQ-SNETANGYFLERSHSARMTLAKACELCPEEEPDDQDAPDEHEPS 2492 >gi|110347427 ubiquitin specific protease 34 [Homo sapiens] Length = 3546 Score = 248 bits (634), Expect = 4e-65 Identities = 192/638 (30%), Positives = 289/638 (45%), Gaps = 43/638 (6%) Query: 1257 CLQLRSQQLASFYNLPCVADFIIDILLGSPSAEIRRVACDQLYTLSQTDTSAHPDVQKPN 1316 C L LA +L D++ + L P +R +C LY LS + + + Sbjct: 1639 CCSLVKSSLADSDHLQ---DWLKKLTLLIPETAVRHESCSGLYKLSLSGLDGGDSINRSF 1695 Query: 1317 QFLLGVILTAQLP---LWSPTSIMRGVNQRLLSQ-CMEYFDLRCQLLDDLTTSEMEQLRI 1372 L L LP P I + +L C EYF L C+L+D++ + Q + Sbjct: 1696 LLLAASTLLKFLPDAQALKPIRIDDYEEEPILKPGCKEYFWLLCKLVDNIHIKDASQTTL 1755 Query: 1373 SPATMLEDEITWLDNFEPNRTAECETSEADNILLAGHLRLIKTLLSLCGAEKEMLGSSLI 1432 L + D + + ++ L G LRL +++ K Sbjct: 1756 LDLDALARHLA--DCIRSREILDHQDGNVEDDGLTGLLRLATSVVKHKPPFKFSREGQ-- 1811 Query: 1433 KPLLDDFLFRASRIILNSHSPAGSAAISQQDFHPKCSTANSRLAAYEVLVMLADSSPSNL 1492 +FL R I N S QQ PKC + +SR AAY++LV + S N Sbjct: 1812 -----EFL----RDIFNLLFLLPSLKDRQQ---PKCKSHSSRAAAYDLLVEMVKGSVENY 1859 Query: 1493 QIIIKELLSMHHQPDPALTKEFDYLPPVDSRSSSGFVGLRNGGATCYMNAVFQQLYMQPG 1552 ++I +++ H Q ++DY P D R+ FVGL N GATCY+ + QQLYM P Sbjct: 1860 RLIHNWVMAQHMQSHAPY--KWDYWPHEDVRAECRFVGLTNLGATCYLASTIQQLYMIPE 1917 Query: 1553 LPESLLSVDDDTDNPDDSVFYQVQSLFGHLMESKLQYYVPENFWKIFKMWNKELYVREQQ 1612 +++ + D + ++Q +F +LMES+ + Y P F K + M + L EQ+ Sbjct: 1918 ARQAVFTAKYSEDMKHKTTLLELQKMFTYLMESECKAYNPRPFCKTYTMDKQPLNTGEQK 1977 Query: 1613 DAYEFFTSLIDQMDEYLKKMGRDQIFKNTFQGIYSDQKICKDCPHRYEREEAFMALNLGV 1672 D EFFT LI +++E ++ K+ F G+ ++ + DC H + E F + V Sbjct: 1978 DMTEFFTDLITKIEEMSPEL--KNTVKSLFGGVITNNVVSLDCEHVSQTAEEFYTVRCQV 2035 Query: 1673 TSCQSLEISLDQFVRGEVLEGSNAYYCEKCKEKRITVKRTCIKSLPSVLVIHLMRFGFDW 1732 +++ SLD+ + LEG N Y C C +K KR C K LP +L + MR+ F+ Sbjct: 2036 ADMKNIYESLDEVTIKDTLEGDNMYTCSHCGKKVRAEKRACFKKLPRILSFNTMRYTFNM 2095 Query: 1733 ESGRSIKYDEQIRFPWMLNMEPYTVSGMARQDSSSEVGENGRSVDQGGGGSPRKKVALTE 1792 + K + FP L+M PYT + SE E + V S K + + Sbjct: 2096 VTMMKEKVNTHFSFPLRLDMTPYTEDFLM---GKSERKEGFKEV------SDHSKDSESY 2146 Query: 1793 NYELVGVIVHSGQAHAGHYYSFIKD---RRGCGKGKWYKFNDTVIEEFDLNDETLEYECF 1849 Y+L+GV VH+G A GHYYSFI+D KWY FND ++ FD L ECF Sbjct: 2147 EYDLIGVTVHTGTADGGHYYSFIRDIVNPHAYKNNKWYLFNDAEVKPFD--SAQLASECF 2204 Query: 1850 GGEYRPKVYDQ-TNPYTDVR-RRYWNAYMLFYQRVSDQ 1885 GGE K YD T+ + D + +AYMLFY+R+ + Sbjct: 2205 GGEMTTKTYDSVTDKFMDFSFEKTHSAYMLFYKRMEPE 2242 Score = 80.5 bits (197), Expect = 2e-14 Identities = 161/753 (21%), Positives = 284/753 (37%), Gaps = 179/753 (23%) Query: 391 KFNSDQLNHLFV--LIQKVLDVLWELAH---LPTLPSSLIQQALEEHLTILSDAYAVKEA 445 +FNS+ + + + + +K +LW++ L LI +A E L + Sbjct: 841 QFNSNAVTDINLDNVCKKGNTLLWDIVQDEDAVNLSEGLINEA--EKLLCSLVCWFTDRQ 898 Query: 446 IKRSYIIKCIEDIKRSSQLNNPQFVWVVPALRQLHEITRSFIKQTYQKQDKSIIQDLKKN 505 I+ +I C+E++ + VV +LR L ++ +F + I +K Sbjct: 899 IRMRFIEGCLENLGNNRS--------VVISLRLLPKLFGTFQQFGSSYDTHWITMWAEKE 950 Query: 506 FEIVKLVTGSLIACHRLAAAVAGPGGLSGSTLVDGR-----YTYREYLEAHLKFLAFFLQ 560 ++KL +L+ + T+ +GR Y++ ++ L+FL Sbjct: 951 LNMMKLFFDNLVYYIQ--------------TVREGRQKHALYSHSAEVQVRLQFLTCVFS 996 Query: 561 EAT----LYLGWNRAKEIWECLVTGQDVCELDREMCFEWF-----TKGQHDLESDVQQQL 611 L + +W CLV + C D WF +K QH + + + L Sbjct: 997 TLGSPDHFRLSLEQVDILWHCLVEDSE-CYDD---ALHWFLNQVRSKDQHAMGMETYKHL 1052 Query: 612 FKEKILKLESYEITMNGFNLFKTFFENVNLCDHRLKRQGAQLYVEKLELIGMDFIWKIAM 671 F EK+ +L+ I+M G NLF+ +LC+ A EL GMD W IA+ Sbjct: 1053 FLEKMPQLKPETISMTGLNLFQ------HLCNLARLATSAYDGCSNSELCGMDQFWGIAL 1106 Query: 672 ESPDEEIANEAIQLIINYSYINLNPRLKKDSVSLHKKFIADCYTRLEAASSALGGPTLTH 731 + +++ AIQ I +Y YIN L+K+ ++FI+ C L ASS+L Sbjct: 1107 RAQSGDVSRAAIQYINSY-YINGKTGLEKE-----QEFISKCMESLMIASSSL------- 1153 Query: 732 AVTRATKMLTATAMPTVATSVQSPYRSTKLVIIERLLLLAERYVITIEDFYSVP-RTILP 790 + L++IER LL+ + ++ ++ R Sbjct: 1154 ----------------------EQESHSSLMVIERGLLMLKTHLEAFRRRFAYHLRQWQI 1191 Query: 791 HGASFHGHL--------LTLNVTYE--STKDTFTVEAHSNETIGSVR-----W--KIAKQ 833 G HL L L V + D T+E + ++ + +R W + K+ Sbjct: 1192 EGTGISSHLKALSDKQSLPLRVVCQPAGLPDKMTIEMYPSDQVADLRAEVTHWYENLQKE 1251 Query: 834 LCSPVDNIQIF--------------------TNDSLLTVNKDQKLLHQLGFSDEQILTVK 873 + +Q F ++ LT + D+K LH+LGF D Q++ V Sbjct: 1252 QINQQAQLQEFGQSNRKGEFPGGLMGPVRMISSGHELTTDYDEKALHELGFKDMQMVFVS 1311 Query: 874 TSGSGTPSGSSADSSTSSSSSSSGVFSSSYAMEQEKSLPGVVMAL---VCNVFDMLYQLA 930 G P + +S Q+ ++P +++ + +FD+L LA Sbjct: 1312 L---GAPRRERKGEGVQ-------LPASCLPPPQKDNIPMLLLLQEPHLTTLFDLLEMLA 1361 Query: 931 NLEEP----------------------RITLRVRKLLLLIPTDPAIQEALDQLDSLGRKK 968 + + P ++ RV +LL+L+PT P + A + Sbjct: 1362 SFKPPSGKVAVDDSESLRCEELHLHAENLSRRVWELLMLLPTCPNMLMAFQNISD----- 1416 Query: 969 TLLSESSSQSSKSPSLSSKQQHQ-PSASSILESLFRSFAPGMSTFRVLYNLEVLSSKLMP 1027 +S+ + L K H+ A I+E+L G R+ S L P Sbjct: 1417 ---EQSNDGFNWKELLKIKSAHKLLYALEIIEAL------GKPNRRIRRESTGSYSDLYP 1467 Query: 1028 TADD---DMARSCAKSFCENFLKAGGLSLVVNV 1057 +DD D + S+ F+ AGGL ++ + Sbjct: 1468 DSDDSSEDQVENSKNSWSCKFVAAGGLQQLLEI 1500 >gi|71774197 ubiquitin specific protease 47 [Homo sapiens] Length = 1287 Score = 146 bits (369), Expect = 2e-34 Identities = 112/395 (28%), Positives = 177/395 (44%), Gaps = 49/395 (12%) Query: 1522 SRSSSGFVGLRNGGATCYMNAVFQQLYMQPGLPESLLS--VDDDTDNPDDSVFYQVQSLF 1579 ++S +G+VGL N TCY+N++ Q L+M P +L ++ ++P S+ YQ+Q LF Sbjct: 93 NKSETGYVGLVNQAMTCYLNSLLQTLFMTPEFRNALYKWEFEESEEDPVTSIPYQLQRLF 152 Query: 1580 GHLMESKLQYYVPENFWKIFKMWNKELYVREQQDAYEFFTSLIDQMDEYLKKMGRDQIFK 1639 L SK + + + F + E + +Q D E + D +++ K+ + + Sbjct: 153 VLLQTSKKRAIETTDVTRSFGWDSSEAW--QQHDVQELCRVMFDALEQKWKQTEQADLIN 210 Query: 1640 NTFQGIYSDQKICKDCPHRYEREEAFMALNLGVT------SCQSLEISLDQFVRGEVLEG 1693 +QG D C +C + R + ++ + L + + S+E +L F++ E+L+G Sbjct: 211 ELYQGKLKDYVRCLECGYEGWRIDTYLDIPLVIRPYGSSQAFASVEEALHAFIQPEILDG 270 Query: 1694 SNAYYCEKCKEKRITVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKYDEQIRFPWMLNM- 1752 N Y+CE+CK+K K P +L + L RF FD+ + IK ++++ FP L+M Sbjct: 271 PNQYFCERCKKKCDARKGLRFLHFPYLLTLQLKRFDFDYTTMHRIKLNDRMTFPEELDMS 330 Query: 1753 ---------EPYTVS---------GMARQDSSSEVGENGRSVDQG------GGGSPRKKV 1788 P T S G D S N VD+G G K Sbjct: 331 TFIDVEDEKSPQTESCTDSGAENEGSCHSDQMSNDFSNDDGVDEGICLETNSGTEKISKS 390 Query: 1789 ALTEN---YELVGVIVHSGQAHAGHYYSFIKDRRGCGKGKWYKFNDTVIEEFDLNDETLE 1845 L +N YEL V+VHSG A GHYY+ IK +WY FND + D Sbjct: 391 GLEKNSLIYELFSVMVHSGSAAGGHYYACIK---SFSDEQWYSFNDQHVSRITQEDIK-- 445 Query: 1846 YECFGGEYRPKVYDQTNPYTDVRRRYWNAYMLFYQ 1880 + GG + Y Y+ NAYML Y+ Sbjct: 446 -KTHGGSSGSRGY-----YSSAFASSTNAYMLIYR 474 >gi|76257392 ubiquitin specific protease 48 isoform b [Homo sapiens] Length = 485 Score = 143 bits (361), Expect = 2e-33 Identities = 115/394 (29%), Positives = 170/394 (43%), Gaps = 68/394 (17%) Query: 1518 PPVDSRSSSGFVGLRNGGATCYMNAVFQQLYMQPGLPESLL-------------SVDDDT 1564 P + R + FVGL N GATCY+N Q ++ L ++L + ++ Sbjct: 78 PNCERRKKNSFVGLTNLGATCYVNTFLQVWFLNLELRQALYLCPSTCSDYMLGDGIQEEK 137 Query: 1565 DNPDDSVFYQVQSLFGHLMESKLQYYVPENFWKIFKMWNKELYVREQQDAYEF---FTSL 1621 D ++ +Q LF L S +Y P F K L +QQDA EF F SL Sbjct: 138 DYEPQTICEHLQYLFALLQNSNRRYIDPSGFVKALG-----LDTGQQQDAQEFSKLFMSL 192 Query: 1622 IDQMDEYLKKMGRDQIFKNTFQGIYSDQKICKDCPHRYEREEAFMALNLGVTSCQSLEIS 1681 ++ K I + F G Y+ +C C + F L L + + L Sbjct: 193 LEDTLSKQKNPDVRNIVQQQFCGEYAYVTVCNQCGRESKLLSKFYELELNIQGHKQLTDC 252 Query: 1682 LDQFVRGEVLEGSNAYYCEKCKEKRITVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKYD 1741 + +F++ E LEG N Y+CE C+ K+ ++ + SLP L + LMRF FD ++G K + Sbjct: 253 ISEFLKEEKLEGDNRYFCENCQSKQNATRKIRLLSLPCTLNLQLMRFVFDRQTGHKKKLN 312 Query: 1742 EQIRFPWMLNMEPYTVSGMARQDSSSEVGENGRSVDQGGGGSPRKKVALTENYELVGVIV 1801 I F +L+MEPY V+ GG + YEL V++ Sbjct: 313 TYIGFSEILDMEPY--------------------VEHKGG---------SYVYELSAVLI 343 Query: 1802 HSG-QAHAGHYYSFIKDRRGCGKGKWYKFNDTVIEEFDLN------DETLEYECFGGEYR 1854 H G A++GHY + +KD + G+WYKFND IE+ + +E L + Sbjct: 344 HRGVSAYSGHYIAHVKDPQ---SGEWYKFNDEDIEKMEGKKLQLGIEEDLAEPSKSQTRK 400 Query: 1855 PKVYDQTNPYTDVRRRYWNAYMLFYQRVSDQNSP 1888 PK T+ NAYML Y R+ Q P Sbjct: 401 PKCGKGTHCSR-------NAYMLVY-RLQTQEKP 426 >gi|52630449 ubiquitin specific protease 48 isoform a [Homo sapiens] Length = 1035 Score = 143 bits (361), Expect = 2e-33 Identities = 115/394 (29%), Positives = 170/394 (43%), Gaps = 68/394 (17%) Query: 1518 PPVDSRSSSGFVGLRNGGATCYMNAVFQQLYMQPGLPESLL-------------SVDDDT 1564 P + R + FVGL N GATCY+N Q ++ L ++L + ++ Sbjct: 78 PNCERRKKNSFVGLTNLGATCYVNTFLQVWFLNLELRQALYLCPSTCSDYMLGDGIQEEK 137 Query: 1565 DNPDDSVFYQVQSLFGHLMESKLQYYVPENFWKIFKMWNKELYVREQQDAYEF---FTSL 1621 D ++ +Q LF L S +Y P F K L +QQDA EF F SL Sbjct: 138 DYEPQTICEHLQYLFALLQNSNRRYIDPSGFVKALG-----LDTGQQQDAQEFSKLFMSL 192 Query: 1622 IDQMDEYLKKMGRDQIFKNTFQGIYSDQKICKDCPHRYEREEAFMALNLGVTSCQSLEIS 1681 ++ K I + F G Y+ +C C + F L L + + L Sbjct: 193 LEDTLSKQKNPDVRNIVQQQFCGEYAYVTVCNQCGRESKLLSKFYELELNIQGHKQLTDC 252 Query: 1682 LDQFVRGEVLEGSNAYYCEKCKEKRITVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKYD 1741 + +F++ E LEG N Y+CE C+ K+ ++ + SLP L + LMRF FD ++G K + Sbjct: 253 ISEFLKEEKLEGDNRYFCENCQSKQNATRKIRLLSLPCTLNLQLMRFVFDRQTGHKKKLN 312 Query: 1742 EQIRFPWMLNMEPYTVSGMARQDSSSEVGENGRSVDQGGGGSPRKKVALTENYELVGVIV 1801 I F +L+MEPY V+ GG + YEL V++ Sbjct: 313 TYIGFSEILDMEPY--------------------VEHKGG---------SYVYELSAVLI 343 Query: 1802 HSG-QAHAGHYYSFIKDRRGCGKGKWYKFNDTVIEEFDLN------DETLEYECFGGEYR 1854 H G A++GHY + +KD + G+WYKFND IE+ + +E L + Sbjct: 344 HRGVSAYSGHYIAHVKDPQ---SGEWYKFNDEDIEKMEGKKLQLGIEEDLAEPSKSQTRK 400 Query: 1855 PKVYDQTNPYTDVRRRYWNAYMLFYQRVSDQNSP 1888 PK T+ NAYML Y R+ Q P Sbjct: 401 PKCGKGTHCSR-------NAYMLVY-RLQTQEKP 426 >gi|150378533 ubiquitin specific peptidase 7 [Homo sapiens] Length = 1102 Score = 119 bits (297), Expect = 5e-26 Identities = 101/366 (27%), Positives = 162/366 (44%), Gaps = 52/366 (14%) Query: 1521 DSRSSSGFVGLRNGGATCYMNAVFQQLYMQPGLPESLLSVDDDTDNPDDSVFYQVQSLFG 1580 DS+ +G+VGL+N GATCYMN++ Q L+ L +++ + + D+ SV +Q +F Sbjct: 206 DSKKHTGYVGLKNQGATCYMNSLLQTLFFTNQLRKAVYMMPTEGDDSSKSVPLALQRVFY 265 Query: 1581 HLMESKLQYYVPENFWKIFKMWNKE-LYVREQQDAYEFFTSLIDQMDEYLKKMGRDQIFK 1639 L S P K+ K + E L Q D E L+D ++ +K + Sbjct: 266 ELQHSD----KPVGTKKLTKSFGWETLDSFMQHDVQELCRVLLDNVENKMKGTCVEGTIP 321 Query: 1640 NTFQGIYSDQKICKDCPHRYEREEAFMALNLGVTSCQSLEISLDQFVRGEVLEGSNAYYC 1699 F+G CK+ +R +R E + + L + +++ S +V E L+G N Y Sbjct: 322 KLFRGKMVSYIQCKEVDYRSDRREDYYDIQLSIKGKKNIFESFVDYVAVEQLDGDNKYDA 381 Query: 1700 EK--CKEKRITVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKYDEQIRFPWMLNMEPYTV 1757 + +E VK +LP VL + LMRF +D ++ ++IK +++ FP L ++ + Sbjct: 382 GEHGLQEAEKGVK---FLTLPPVLHLQLMRFMYDPQTDQNIKINDRFEFPEQLPLDEF-- 436 Query: 1758 SGMARQDSSSEVGENGRSVDQGGGGSPRKKVALTENYELVGVIVHSGQAHAGHYYSFIKD 1817 + + D NY L V+VHSG H GHY ++ Sbjct: 437 --LQKTDPKDPA-----------------------NYILHAVLVHSGDNHGGHYVVYLNP 471 Query: 1818 RRGCGKGKWYKFNDTVIEEFDLNDETLEYECFGGEYRPKVYDQTNPYTDVRRRYWNAYML 1877 + G GKW KF+D V+ +E +E+ G + V R NAYML Sbjct: 472 K---GDGKWCKFDDDVVSRC-TKEEAIEHNYGGHDDDLSV-----------RHCTNAYML 516 Query: 1878 FYQRVS 1883 Y R S Sbjct: 517 VYIRES 522 >gi|41055953 ubiquitin thioesterase 40 [Homo sapiens] Length = 1247 Score = 115 bits (287), Expect = 7e-25 Identities = 85/312 (27%), Positives = 132/312 (42%), Gaps = 39/312 (12%) Query: 1517 LPPVDSRSSSGFVGLRNGGATCYMNAVFQQLYMQPGLPESLLSVD-------DDTDNPDD 1569 L P R + G+RN G TCY+N++ Q L+ P E+L S+ +D D PD Sbjct: 41 LEPPAPREFTNLSGIRNQGGTCYLNSLLQTLHFTPEFREALFSLGPEELGLFEDKDKPDA 100 Query: 1570 SVFY---QVQSLFGHLMESKLQYYVPENFWKIFKMWNKELYVREQQDAYEFFTSLIDQMD 1626 V Q+Q LF L+ + + F W +R Q D E L ++ Sbjct: 101 KVRIIPLQLQRLFAQLLLLDQEAASTADLTDSFG-WTSNEEMR-QHDVQELNRILFSALE 158 Query: 1627 EYLKKMGRDQIFKNTFQGIYSDQKICKDCPHRYEREEAFMALNLGVTSCQSLEISL-DQF 1685 L + + G +Q +CK+C + ER+E F+ L + V + LE +L + + Sbjct: 159 TSLVGTSGHDLIYRLYHGTIVNQIVCKECKNVSERQEDFLDLTVAVKNVSGLEDALWNMY 218 Query: 1686 VRGEVLEGSNAYYCEKCKEKRITVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKYDEQIR 1745 V EV + N Y+C C K ++ LP L + L+RF FD+ K Sbjct: 219 VEEEVFDCDNLYHCGTCDRLVKAAKSAKLRKLPPFLTVSLLRFNFDFVKCERYKETSCYT 278 Query: 1746 FPWMLNMEPYTVSGMARQDSSSEVGENGRSVDQGGGGSPRKKVALTENYELVGVIVHSGQ 1805 FP +N++P+ SE+ + L Y+L VI+H G Sbjct: 279 FPLRINLKPFC--------EQSELDD------------------LEYIYDLFSVIIHKGG 312 Query: 1806 AHAGHYYSFIKD 1817 + GHY+ +IKD Sbjct: 313 CYGGHYHVYIKD 324 >gi|122114651 ubiquitin specific peptidase 36 [Homo sapiens] Length = 1123 Score = 103 bits (258), Expect = 2e-21 Identities = 104/406 (25%), Positives = 161/406 (39%), Gaps = 85/406 (20%) Query: 1530 GLRNGGATCYMNAVFQQLYMQPGLPESLLSVDDDTDNPDDSVFYQVQSLFGHLMESKLQY 1589 GL N G TC++NA Q L P L LLS + S F + + H++++ Sbjct: 123 GLHNLGNTCFLNATIQCLTYTPPLANYLLSKEHARSCHQGS-FCMLCVMQNHIVQAFANS 181 Query: 1590 ---YVPENFWKIFKMWNKELYVREQQDAYEFFTSLIDQMDEYL----KKMGRDQ----IF 1638 P +F + K + Q+DA+EF ID M + K+ R + Sbjct: 182 GNAIKPVSFIRDLKKIARHFRFGNQEDAHEFLRYTIDAMQKACLNGCAKLDRQTQATTLV 241 Query: 1639 KNTFQGIYSDQKICKDCPHRYEREEAFMALNLGVTSCQSLEISLDQFVRGEVLEGSNAYY 1698 F G + C C + + ++ + L + ++ +L+ FV+ +VL G NAY Sbjct: 242 HQIFGGYLRSRVKCSVCKSVSDTYDPYLDVALEIRQAANIVRALELFVKADVLSGENAYM 301 Query: 1699 CEKCKEKRITVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKYDEQIRFPWMLNMEPYTVS 1758 C KCK+K KR I +VL + L RF ++ G K + + +P LN+ PY Sbjct: 302 CAKCKKKVPASKRFTIHRTSNVLTLSLKRFA-NFSGG---KITKDVGYPEFLNIRPYMSQ 357 Query: 1759 GMARQDSSSEVGENGRSVDQGGGGSPRKKVALTENYELVGVIVHSG-QAHAGHYYSFIKD 1817 NG V Y L V+VHSG HAGHYY ++K Sbjct: 358 ------------NNGDPV----------------MYGLYAVLVHSGYSCHAGHYYCYVK- 388 Query: 1818 RRGCGKGKWYKFNDTVIEEFDLNDETLEYECFGGEYRPKVYDQTNPYTDVRRRYWNAYML 1877 G+WY+ ND+++ ++ V +Q AY+L Sbjct: 389 ---ASNGQWYQMNDSLVHSSNVK---------------VVLNQ------------QAYVL 418 Query: 1878 FYQRVSDQNSPVLPKKSRVSVVRQEAEDLSLSAPSSPEISPQSSPR 1923 FY R+ KKS ++ + S S P P + P S + Sbjct: 419 FYLRIPGS------KKSPEGLISRTG---SSSLPGRPSVIPDHSKK 455 >gi|197116355 ubiquitin specific peptidase 46 isoform 2 [Homo sapiens] Length = 359 Score = 101 bits (252), Expect = 8e-21 Identities = 98/379 (25%), Positives = 156/379 (41%), Gaps = 75/379 (19%) Query: 1528 FVGLRNGGATCYMNAVFQQLYMQPGLPESLLSVDDDTDNPDDSVFYQVQSLFGHLMESKL 1587 + GL N G TCY N+V Q LY E++L+ +++ + LF + K Sbjct: 27 YFGLVNFGNTCYCNSVLQALYFCRPFRENVLAYKAQ-QKKKENLLTCLADLFHSIATQKK 85 Query: 1588 QYYV--PENFWKIFKMWNKELYVREQQDAYEFFTSLI----DQMDEYLKKMGRDQIFKN- 1640 + V P+ F + N QQDA+EF L+ D + E K+ ++ KN Sbjct: 86 KVGVIPPKKFISRLRKENDLFDNYMQQDAHEFLNYLLNTIADILQEEKKQEKQNGKLKNG 145 Query: 1641 ------------------TFQGIYSDQKICKDCPHRYEREEAFMALNLGVTSCQSLEISL 1682 FQG +++ C +C ++E F+ L++ V S+ L Sbjct: 146 NMNEPAENNKPELTWVHEIFQGTLTNETRCLNCETVSSKDEDFLDLSVDVEQNTSITHCL 205 Query: 1683 DQFVRGEVLEGSNAYYCEKCKEKRITVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKYDE 1742 F E L YYCE C K+ KR +K LP +L +HL RF + + R K Sbjct: 206 RDFSNTETLCSEQKYYCETCCSKQEAQKRMRVKKLPMILALHLKRFKYMEQLHRYTKLSY 265 Query: 1743 QIRFPWMLNMEPYTVSGMARQDSSSEVGENGRSVDQGGGGSPRKKVALTENYELVGVIVH 1802 ++ FP L + ++SS+ V L Y+LV V+VH Sbjct: 266 RVVFPLELRLF----------NTSSDA------------------VNLDRMYDLVAVVVH 297 Query: 1803 SGQA-HAGHYYSFIKDRRGCGKGKWYKFNDTVIEEFDLNDETLEYECFGGEYRPKVYDQT 1861 G + GHY + +K G W F+D ++E+ D + +E + Y T Sbjct: 298 CGSGPNRGHYITIVKSH-----GFWLLFDDDIVEKIDA--QAIE----------EFYGLT 340 Query: 1862 NPYTDVRRRYWNAYMLFYQ 1880 +D+ + + Y+LFYQ Sbjct: 341 ---SDISKNSESGYILFYQ 356 >gi|31377709 ubiquitin specific peptidase 46 isoform 1 [Homo sapiens] Length = 366 Score = 101 bits (252), Expect = 8e-21 Identities = 98/379 (25%), Positives = 156/379 (41%), Gaps = 75/379 (19%) Query: 1528 FVGLRNGGATCYMNAVFQQLYMQPGLPESLLSVDDDTDNPDDSVFYQVQSLFGHLMESKL 1587 + GL N G TCY N+V Q LY E++L+ +++ + LF + K Sbjct: 34 YFGLVNFGNTCYCNSVLQALYFCRPFRENVLAYKAQ-QKKKENLLTCLADLFHSIATQKK 92 Query: 1588 QYYV--PENFWKIFKMWNKELYVREQQDAYEFFTSLI----DQMDEYLKKMGRDQIFKN- 1640 + V P+ F + N QQDA+EF L+ D + E K+ ++ KN Sbjct: 93 KVGVIPPKKFISRLRKENDLFDNYMQQDAHEFLNYLLNTIADILQEEKKQEKQNGKLKNG 152 Query: 1641 ------------------TFQGIYSDQKICKDCPHRYEREEAFMALNLGVTSCQSLEISL 1682 FQG +++ C +C ++E F+ L++ V S+ L Sbjct: 153 NMNEPAENNKPELTWVHEIFQGTLTNETRCLNCETVSSKDEDFLDLSVDVEQNTSITHCL 212 Query: 1683 DQFVRGEVLEGSNAYYCEKCKEKRITVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKYDE 1742 F E L YYCE C K+ KR +K LP +L +HL RF + + R K Sbjct: 213 RDFSNTETLCSEQKYYCETCCSKQEAQKRMRVKKLPMILALHLKRFKYMEQLHRYTKLSY 272 Query: 1743 QIRFPWMLNMEPYTVSGMARQDSSSEVGENGRSVDQGGGGSPRKKVALTENYELVGVIVH 1802 ++ FP L + ++SS+ V L Y+LV V+VH Sbjct: 273 RVVFPLELRLF----------NTSSDA------------------VNLDRMYDLVAVVVH 304 Query: 1803 SGQA-HAGHYYSFIKDRRGCGKGKWYKFNDTVIEEFDLNDETLEYECFGGEYRPKVYDQT 1861 G + GHY + +K G W F+D ++E+ D + +E + Y T Sbjct: 305 CGSGPNRGHYITIVKSH-----GFWLLFDDDIVEKIDA--QAIE----------EFYGLT 347 Query: 1862 NPYTDVRRRYWNAYMLFYQ 1880 +D+ + + Y+LFYQ Sbjct: 348 ---SDISKNSESGYILFYQ 363 >gi|32698815 ubiquitin thiolesterase 12 [Homo sapiens] Length = 370 Score = 100 bits (248), Expect = 2e-20 Identities = 103/398 (25%), Positives = 162/398 (40%), Gaps = 78/398 (19%) Query: 1509 ALTKEFDYLPPVDSRSSSGFVGLRNGGATCYMNAVFQQLYMQPGLPESLLSVDDDTDNPD 1568 AL KE + P + + GL N G TCY N+V Q LY E +L+ Sbjct: 22 ALEKE---IGPEQFPVNEHYFGLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQP-RKK 77 Query: 1569 DSVFYQVQSLFGHLMESKLQYYV--PENFWKIFKMWNKELYVREQQDAYEFFTSLIDQMD 1626 +S+ + LF + K + V P+ F + N+ QQDA+EF L++ + Sbjct: 78 ESLLTCLADLFHSIATQKKKVGVIPPKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIA 137 Query: 1627 EYL-------KKMGR------DQIFKNT----------FQGIYSDQKICKDCPHRYEREE 1663 + L K+ GR D N+ FQG +++ C C ++E Sbjct: 138 DILQEERKQEKQNGRLPNGNIDNENNNSTPDPTWVDEIFQGTLTNETRCLTCETISSKDE 197 Query: 1664 AFMALNLGVTSCQSLEISLDQFVRGEVLEGSNAYYCEKCKEKRITVKRTCIKSLPSVLVI 1723 F+ L++ V S+ L F E L YYCE+C+ K+ KR +K LP +L + Sbjct: 198 DFLDLSVDVEQNTSITHCLRGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILAL 257 Query: 1724 HLMRFGFDWESGRSIKYDEQIRFPWMLNMEPYTVSGMARQDSSSEVGENGRSVDQGGGGS 1783 HL RF + + R K ++ FP L + + SG A Sbjct: 258 HLKRFKYMDQLHRYTKLSYRVVFP--LELRLFNTSGDATNPD------------------ 297 Query: 1784 PRKKVALTENYELVGVIVHSGQA-HAGHYYSFIKDRRGCGKGKWYKFNDTVIEEFDLNDE 1842 Y+LV V+VH G + GHY + +K W F+D ++E+ D + Sbjct: 298 --------RMYDLVAVVVHCGSGPNRGHYIAIVKSH-----DFWLLFDDDIVEKIDA--Q 342 Query: 1843 TLEYECFGGEYRPKVYDQTNPYTDVRRRYWNAYMLFYQ 1880 +E + Y T +D+ + + Y+LFYQ Sbjct: 343 AIE----------EFYGLT---SDISKNSESGYILFYQ 367 >gi|190684694 ubiquitin specific peptidase 8 [Homo sapiens] Length = 1118 Score = 97.4 bits (241), Expect = 1e-19 Identities = 96/386 (24%), Positives = 155/386 (40%), Gaps = 78/386 (20%) Query: 1517 LPPVDSRSSSGFVGLRNGGATCYMNAVFQQLYMQPGLPESL-LSVDDDTDNPDDSVFY-- 1573 L PV S GLRN G TCYMN++ Q L P L + + D N + + + Sbjct: 765 LNPVFGGSGPALTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKG 824 Query: 1574 QVQSLFGHLMES----KLQYYVPENFWKIFKMWNKELYVREQQDAYEFFTSLIDQMDEYL 1629 +V FG +M++ + +Y P++F N + QQD+ E L+D + E L Sbjct: 825 EVAEEFGIIMKALWTGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDL 884 Query: 1630 KKMGRDQIFKNT-----------------------------FQGIYSDQKICKDCPHRYE 1660 K + +K FQG + C C + Sbjct: 885 NKADNRKRYKEENNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSR 944 Query: 1661 REEAFMALNLGVTSCQ--SLEISLDQFVRGEVLEGSNAYYCEKCKEKRITVKRTCIKSLP 1718 EAFM L+L + S +L+ L F + E L +N +YC C+ +R ++K+ I LP Sbjct: 945 TFEAFMYLSLPLASTSKCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLP 1004 Query: 1719 SVLVIHLMRFGFD--WESGRSIKYDEQIRFPW-MLNMEPYTVSGMARQDSSSEVGENGRS 1775 VL++HL RF +D W+ K + FP L++ Y + Sbjct: 1005 PVLLVHLKRFSYDGRWKQ----KLQTSVDFPLENLDLSQYVI------------------ 1042 Query: 1776 VDQGGGGSPRKKVALTENYELVGVIVHSGQAHAGHYYSFIKDRRGCGKGKWYKFNDTVIE 1835 P+ + + Y L V H G GHY ++ K+ + +W+KF+D + Sbjct: 1043 -------GPKNNL---KKYNLFSVSNHYGGLDGGHYTAYCKN---AARQRWFKFDDHEVS 1089 Query: 1836 EFDLND--ETLEYECFGGEYRPKVYD 1859 + ++ + Y F P+V D Sbjct: 1090 DISVSSVKSSAAYILFYTSLGPRVTD 1115 >gi|190684692 ubiquitin specific peptidase 8 [Homo sapiens] Length = 1118 Score = 97.4 bits (241), Expect = 1e-19 Identities = 96/386 (24%), Positives = 155/386 (40%), Gaps = 78/386 (20%) Query: 1517 LPPVDSRSSSGFVGLRNGGATCYMNAVFQQLYMQPGLPESL-LSVDDDTDNPDDSVFY-- 1573 L PV S GLRN G TCYMN++ Q L P L + + D N + + + Sbjct: 765 LNPVFGGSGPALTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKG 824 Query: 1574 QVQSLFGHLMES----KLQYYVPENFWKIFKMWNKELYVREQQDAYEFFTSLIDQMDEYL 1629 +V FG +M++ + +Y P++F N + QQD+ E L+D + E L Sbjct: 825 EVAEEFGIIMKALWTGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDL 884 Query: 1630 KKMGRDQIFKNT-----------------------------FQGIYSDQKICKDCPHRYE 1660 K + +K FQG + C C + Sbjct: 885 NKADNRKRYKEENNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSR 944 Query: 1661 REEAFMALNLGVTSCQ--SLEISLDQFVRGEVLEGSNAYYCEKCKEKRITVKRTCIKSLP 1718 EAFM L+L + S +L+ L F + E L +N +YC C+ +R ++K+ I LP Sbjct: 945 TFEAFMYLSLPLASTSKCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLP 1004 Query: 1719 SVLVIHLMRFGFD--WESGRSIKYDEQIRFPW-MLNMEPYTVSGMARQDSSSEVGENGRS 1775 VL++HL RF +D W+ K + FP L++ Y + Sbjct: 1005 PVLLVHLKRFSYDGRWKQ----KLQTSVDFPLENLDLSQYVI------------------ 1042 Query: 1776 VDQGGGGSPRKKVALTENYELVGVIVHSGQAHAGHYYSFIKDRRGCGKGKWYKFNDTVIE 1835 P+ + + Y L V H G GHY ++ K+ + +W+KF+D + Sbjct: 1043 -------GPKNNL---KKYNLFSVSNHYGGLDGGHYTAYCKN---AARQRWFKFDDHEVS 1089 Query: 1836 EFDLND--ETLEYECFGGEYRPKVYD 1859 + ++ + Y F P+V D Sbjct: 1090 DISVSSVKSSAAYILFYTSLGPRVTD 1115 >gi|190684690 ubiquitin specific peptidase 8 [Homo sapiens] Length = 1118 Score = 97.4 bits (241), Expect = 1e-19 Identities = 96/386 (24%), Positives = 155/386 (40%), Gaps = 78/386 (20%) Query: 1517 LPPVDSRSSSGFVGLRNGGATCYMNAVFQQLYMQPGLPESL-LSVDDDTDNPDDSVFY-- 1573 L PV S GLRN G TCYMN++ Q L P L + + D N + + + Sbjct: 765 LNPVFGGSGPALTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKG 824 Query: 1574 QVQSLFGHLMES----KLQYYVPENFWKIFKMWNKELYVREQQDAYEFFTSLIDQMDEYL 1629 +V FG +M++ + +Y P++F N + QQD+ E L+D + E L Sbjct: 825 EVAEEFGIIMKALWTGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDL 884 Query: 1630 KKMGRDQIFKNT-----------------------------FQGIYSDQKICKDCPHRYE 1660 K + +K FQG + C C + Sbjct: 885 NKADNRKRYKEENNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSR 944 Query: 1661 REEAFMALNLGVTSCQ--SLEISLDQFVRGEVLEGSNAYYCEKCKEKRITVKRTCIKSLP 1718 EAFM L+L + S +L+ L F + E L +N +YC C+ +R ++K+ I LP Sbjct: 945 TFEAFMYLSLPLASTSKCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLP 1004 Query: 1719 SVLVIHLMRFGFD--WESGRSIKYDEQIRFPW-MLNMEPYTVSGMARQDSSSEVGENGRS 1775 VL++HL RF +D W+ K + FP L++ Y + Sbjct: 1005 PVLLVHLKRFSYDGRWKQ----KLQTSVDFPLENLDLSQYVI------------------ 1042 Query: 1776 VDQGGGGSPRKKVALTENYELVGVIVHSGQAHAGHYYSFIKDRRGCGKGKWYKFNDTVIE 1835 P+ + + Y L V H G GHY ++ K+ + +W+KF+D + Sbjct: 1043 -------GPKNNL---KKYNLFSVSNHYGGLDGGHYTAYCKN---AARQRWFKFDDHEVS 1089 Query: 1836 EFDLND--ETLEYECFGGEYRPKVYD 1859 + ++ + Y F P+V D Sbjct: 1090 DISVSSVKSSAAYILFYTSLGPRVTD 1115 >gi|79750944 ubiquitin specific peptidase 42 [Homo sapiens] Length = 1316 Score = 96.7 bits (239), Expect = 3e-19 Identities = 82/328 (25%), Positives = 142/328 (43%), Gaps = 61/328 (18%) Query: 1530 GLRNGGATCYMNAVFQQLYMQPGLPESLLSVDDDTDNPDDSVFYQVQSLFGHLMES---- 1585 GL+N G TC+ NA Q L P L +LS + + F + ++ H+ ++ Sbjct: 112 GLQNLGNTCFANAALQCLTYTPPLANYMLS-HEHSKTCHAEGFCMMCTMQAHITQALSNP 170 Query: 1586 ----KLQYYVPENFWKIFKMWNKELYVREQQDAYEFFTSLIDQMDEYLKKMGRDQIFKNT 1641 K + + E + + Q+DA+EF +D M + G +++ ++T Sbjct: 171 GDVIKPMFVINE-----MRRIARHFRFGNQEDAHEFLQYTVDAMQKACLN-GSNKLDRHT 224 Query: 1642 ---------FQGIYSDQKICKDCPHRYEREEAFMALNLGVTSCQSLEISLDQFVRGEVLE 1692 F G + C +C + + ++ + L + + QS+ +L+QFV+ E L+ Sbjct: 225 QATTLVCQIFGGYLRSRVKCLNCKGVSDTFDPYLDITLEIKAAQSVNKALEQFVKPEQLD 284 Query: 1693 GSNAYYCEKCKEKRITVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKYDEQIRFPWMLNM 1752 G N+Y C KCK+ KR I +VL + L RF ++ G+ K +++P L++ Sbjct: 285 GENSYKCSKCKKMVPASKRFTIHRSSNVLTLSLKRFA-NFTGGKIAK---DVKYPEYLDI 340 Query: 1753 EPYTVSGMARQDSSSEVGENGRSVDQGGGGSPRKKVALTENYELVGVIVHSG-QAHAGHY 1811 PY NG + Y L V+VH+G HAGHY Sbjct: 341 RPYMSQ------------PNGEPI----------------VYVLYAVLVHTGFNCHAGHY 372 Query: 1812 YSFIKDRRGCGKGKWYKFNDTVIEEFDL 1839 + +IK G WY+ ND+++ D+ Sbjct: 373 FCYIK----ASNGLWYQMNDSIVSTSDI 396 >gi|239757637 PREDICTED: ubiquitin specific peptidase 41 [Homo sapiens] Length = 344 Score = 95.9 bits (237), Expect = 4e-19 Identities = 85/325 (26%), Positives = 133/325 (40%), Gaps = 35/325 (10%) Query: 1517 LPPVDSRSSSGFVGLRNGGATCYMNAVFQQLYMQPGLPESL--LSVDDDTDNPDDSVFYQ 1574 +P + G VGL N G TC +N++ Q M L ++V D SV +Q Sbjct: 9 VPKISWDYRHGLVGLHNIGQTCCLNSLIQVFVMNVDFARILKRITVPRGADEQRRSVPFQ 68 Query: 1575 VQSLFGHLMESKLQYYVPENFWKIFKMWNKELYVREQQDAYEFFTSLIDQMDEYLKKMGR 1634 + L + +S+ + P + +N L+V Q DA + + L + + + + + Sbjct: 69 MLLLLEKMQDSRQKAVWPLELAYCLQKYNVPLFV--QHDAAQLYLKLWNLIKDQIADVHL 126 Query: 1635 DQIFKNTFQGIYSDQKICKDCPHRYEREEAFMALNLGVTSCQS-----LEISLDQFVRGE 1689 + + + D IC DC R + + L L S LE +L F + Sbjct: 127 VERLQALYMIRVKDSLICLDCAMESSRNSSMLTLRLSFFDVDSKPLKTLEDALHCFFQPR 186 Query: 1690 VLEGSNAYYCEKCKEKRITVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKYDEQIRFPWM 1749 L + +CE C +K + + LP L IHLMRF + ++ K + FP Sbjct: 187 ELSSKSKCFCENCGKKTRGKQVLKLTHLPQTLTIHLMRFSI--RNSQTRKICHSLYFPQS 244 Query: 1750 LNMEPYTVSGMARQDSSSEVGENGRSVDQGGGGSPRKKVALTENYELVGVIVHSGQAHAG 1809 L+ + M R+ +E +Q GG YEL VI H G A +G Sbjct: 245 LDFS--QILPMKRESCDAE--------EQSGG-----------QYELFAVIAHVGMADSG 283 Query: 1810 HYYSFIKDRRGCGKGKWYKFNDTVI 1834 HY +I R GKW+ FND+ I Sbjct: 284 HYCVYI---RSAVDGKWFCFNDSNI 305 >gi|169215723 PREDICTED: ubiquitin specific peptidase 41 [Homo sapiens] Length = 346 Score = 95.5 bits (236), Expect = 6e-19 Identities = 84/315 (26%), Positives = 130/315 (41%), Gaps = 35/315 (11%) Query: 1527 GFVGLRNGGATCYMNAVFQQLYMQPGLPESL--LSVDDDTDNPDDSVFYQVQSLFGHLME 1584 G VGL N G TC +N++ Q M L ++V D SV +Q+ L + + Sbjct: 42 GLVGLHNIGQTCCLNSLIQVFVMNVDFARILKRITVPRGADEQRRSVPFQMLLLLEKMQD 101 Query: 1585 SKLQYYVPENFWKIFKMWNKELYVREQQDAYEFFTSLIDQMDEYLKKMGRDQIFKNTFQG 1644 S+ + P + +N L+V Q DA + + L + + + + + + + + Sbjct: 102 SRQKAVWPLELAYCLQKYNVPLFV--QHDAAQLYLKLWNLIKDQIADVHLVERLQALYMI 159 Query: 1645 IYSDQKICKDCPHRYEREEAFMALNLGVTSCQS-----LEISLDQFVRGEVLEGSNAYYC 1699 D IC DC R + + L L S LE +L F + L + +C Sbjct: 160 RMKDSLICLDCAMESSRNSSMLTLRLSFFDVDSKPLKTLEDALHCFFQPRELSSKSKCFC 219 Query: 1700 EKCKEKRITVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKYDEQIRFPWMLNMEPYTVSG 1759 E C +K + + LP L IHLMRF + ++ K + FP L+ + Sbjct: 220 ENCGKKTRGKQVLKLTHLPQTLTIHLMRFSI--RNSQTRKICHSLYFPQSLDFS--QILP 275 Query: 1760 MARQDSSSEVGENGRSVDQGGGGSPRKKVALTENYELVGVIVHSGQAHAGHYYSFIKDRR 1819 M R+ +E +Q GG YEL VI H G A +GHY +I R Sbjct: 276 MKRESCDAE--------EQSGG-----------QYELFAVIAHVGMADSGHYCVYI---R 313 Query: 1820 GCGKGKWYKFNDTVI 1834 GKW+ FND+ I Sbjct: 314 NAVDGKWFCFNDSNI 328 >gi|239746654 PREDICTED: ubiquitin specific protease 41 [Homo sapiens] Length = 347 Score = 95.5 bits (236), Expect = 6e-19 Identities = 84/315 (26%), Positives = 130/315 (41%), Gaps = 35/315 (11%) Query: 1527 GFVGLRNGGATCYMNAVFQQLYMQPGLPESL--LSVDDDTDNPDDSVFYQVQSLFGHLME 1584 G VGL N G TC +N++ Q M L ++V D SV +Q+ L + + Sbjct: 42 GLVGLHNIGQTCCLNSLIQVFVMNVDFARILKRITVPRGADEQRRSVPFQMLLLLEKMQD 101 Query: 1585 SKLQYYVPENFWKIFKMWNKELYVREQQDAYEFFTSLIDQMDEYLKKMGRDQIFKNTFQG 1644 S+ + P + +N L+V Q DA + + L + + + + + + + + Sbjct: 102 SRQKAVWPLELAYCLQKYNVPLFV--QHDAAQLYLKLWNLIKDQIADVHLVERLQALYMI 159 Query: 1645 IYSDQKICKDCPHRYEREEAFMALNLGVTSCQS-----LEISLDQFVRGEVLEGSNAYYC 1699 D IC DC R + + L L S LE +L F + L + +C Sbjct: 160 RMKDSLICLDCAMESSRNSSMLTLRLSFFDVDSKPLKTLEDALHCFFQPRELSSKSKCFC 219 Query: 1700 EKCKEKRITVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKYDEQIRFPWMLNMEPYTVSG 1759 E C +K + + LP L IHLMRF + ++ K + FP L+ + Sbjct: 220 ENCGKKTRGKQVLKLTHLPQTLTIHLMRFSI--RNSQTRKICHSLYFPQSLDFS--QILP 275 Query: 1760 MARQDSSSEVGENGRSVDQGGGGSPRKKVALTENYELVGVIVHSGQAHAGHYYSFIKDRR 1819 M R+ +E +Q GG YEL VI H G A +GHY +I R Sbjct: 276 MKRESCDAE--------EQSGG-----------QYELFAVIAHVGMADSGHYCVYI---R 313 Query: 1820 GCGKGKWYKFNDTVI 1834 GKW+ FND+ I Sbjct: 314 NAVDGKWFCFNDSNI 328 >gi|32313610 ubiquitin specific protease 18 [Homo sapiens] Length = 372 Score = 95.5 bits (236), Expect = 6e-19 Identities = 94/361 (26%), Positives = 150/361 (41%), Gaps = 45/361 (12%) Query: 1483 MLADSS--PSNLQIIIKELLSMHHQPDPALTKEFDYLPPVDSRSSSGFVGLRNGGATCYM 1540 +LA+SS P++L+ +E +M + + +DY G VGL N G TC + Sbjct: 15 ILAESSQSPADLEEKKEEDSNMKREQPRERPRAWDY--------PHGLVGLHNIGQTCCL 66 Query: 1541 NAVFQQLYMQPGLPESL--LSVDDDTDNPDDSVFYQVQSLFGHLMESKLQYYVPENFWKI 1598 N++ Q M L ++V D SV +Q+ L + +S+ + P Sbjct: 67 NSLIQVFVMNVDFTRILKRITVPRGADEQRRSVPFQMLLLLEKMQDSRQKAVRPLELAYC 126 Query: 1599 FKMWNKELYVREQQDAYEFFTSLIDQMDEYLKKMGRDQIFKNTFQGIYSDQKICKDCPHR 1658 + N L+V Q DA + + L + + + + + + + + D IC DC Sbjct: 127 LQKCNVPLFV--QHDAAQLYLKLWNLIKDQITDVHLVERLQALYTIRVKDSLICVDCAME 184 Query: 1659 YEREEAFMALNLGVTSCQS-----LEISLDQFVRGEVLEGSNAYYCEKCKEKRITVKRTC 1713 R + + L L + S LE +L F + L + +CE C +K + Sbjct: 185 SSRNSSMLTLPLSLFDVDSKPLKTLEDALHCFFQPRELSSKSKCFCENCGKKTRGKQVLK 244 Query: 1714 IKSLPSVLVIHLMRFGFDWESGRSIKYDEQIRFPWMLNMEPYTVSGMARQDSSSEVGENG 1773 + LP L IHLMRF + ++ K + FP L+ + M R+ +E Sbjct: 245 LTHLPQTLTIHLMRFSI--RNSQTRKICHSLYFPQSLDFS--QILPMKRESCDAE----- 295 Query: 1774 RSVDQGGGGSPRKKVALTENYELVGVIVHSGQAHAGHYYSFIKDRRGCGKGKWYKFNDTV 1833 +Q GG YEL VI H G A +GHY +I R GKW+ FND+ Sbjct: 296 ---EQSGG-----------QYELFAVIAHVGMADSGHYCVYI---RNAVDGKWFCFNDSN 338 Query: 1834 I 1834 I Sbjct: 339 I 339 >gi|239742276 PREDICTED: hypothetical protein XP_002342471 [Homo sapiens] Length = 530 Score = 92.4 bits (228), Expect = 5e-18 Identities = 80/327 (24%), Positives = 146/327 (44%), Gaps = 50/327 (15%) Query: 1518 PPVDSRSSSGF-VGLRNGGATCYMNAVFQQLYMQPGLPESLLSVDDDTDNPDDSVFYQVQ 1576 PP+ SR + GL+N G TCY+NA Q L +P L +L + + + Sbjct: 68 PPLSSRRPAAVGAGLQNMGNTCYVNASLQCLTYKPPLANYML-FREHSQTCHRHKGCMLC 126 Query: 1577 SLFGHLMESKLQYYVPENFWKIFKMWNKELYVREQQDAYEFFTSLIDQMDEYL----KKM 1632 ++ H+ + ++P + + + + +Q+DA+EF +D M + K++ Sbjct: 127 TMQAHITRA---LHIPGHVIQPSQALAAGFHRGKQEDAHEFLMFTVDAMRKACLPGHKQV 183 Query: 1633 GRDQ----IFKNTFQGIYSDQKICKDCPHRYEREEAFMALNLGVTSCQSLEISLDQFVRG 1688 R + F G + Q C C + + ++ + L + + QS++ +L+Q V+ Sbjct: 184 DRHSKDTTLIHQIFGGYWRSQIKCLHCHGISDTFDPYLDIALDIQAAQSVQQALEQLVKP 243 Query: 1689 EVLEGSNAYYCEKCKEKRITVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKYDEQIRFPW 1748 E L G NAY+C C ++ K + + VL++ L RF K + +++P Sbjct: 244 EELNGENAYHCGVCLQRAPASKTLTLHNSAKVLILVLKRF----PDVTGNKIAKNVQYPE 299 Query: 1749 MLNMEPYTVSGMARQDSSSEVGENGRSVDQGGGGSPRKKVALTENYELVGVIVHSG-QAH 1807 L+M+PY M++Q++ V Y L V+VH+G H Sbjct: 300 CLDMQPY----MSQQNTGPLV------------------------YVLYAVLVHAGWSCH 331 Query: 1808 AGHYYSFIKDRRGCGKGKWYKFNDTVI 1834 GHY S++K + +G+WYK +D + Sbjct: 332 NGHYSSYVKAQ----EGQWYKMDDAEV 354 >gi|153792150 deubiquitinating enzyme 3 [Homo sapiens] Length = 530 Score = 91.7 bits (226), Expect = 8e-18 Identities = 82/332 (24%), Positives = 140/332 (42%), Gaps = 59/332 (17%) Query: 1517 LPPVDSRSSSGFVGLRNGGATCYMNAVFQQLYMQPGLPESLLSVDDDT--DNPDDSVFYQ 1574 LP R ++ GL+N G TCY NA Q L P L +LS + P + Sbjct: 68 LPLSSRRPAAVGAGLQNMGNTCYENASLQCLTYTPPLANYMLSREHSQTCQRPKCCMLCT 127 Query: 1575 VQSLFGHLMESKLQYYVPENFWKIFKMWNKELYVREQQDAYEFFTSLID----------- 1623 +Q+ + S P + + +Q+DA+EF +D Sbjct: 128 MQAHITWALHSPGHVIQPS------QALAAGFHRGKQEDAHEFLMFTVDAMKKACLPGHK 181 Query: 1624 QMDEYLKKMGRDQIFKNTFQGIYSDQKICKDCPHRYEREEAFMALNLGVTSCQSLEISLD 1683 Q+D + K + F G + Q C C + + ++ + L + + QS++ +L+ Sbjct: 182 QVDHHSKDT---TLIHQIFGGCWRSQIKCLHCHGISDTFDPYLDIALDIQAAQSVKQALE 238 Query: 1684 QFVRGEVLEGSNAYYCEKCKEKRITVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKYDEQ 1743 Q V+ E L G NAY+C C ++ K + + VL++ L RF K + Sbjct: 239 QLVKPEELNGENAYHCGLCLQRAPASKTLTLHTSAKVLILVLKRF----SDVTGNKLAKN 294 Query: 1744 IRFPWMLNMEPYTVSGMARQDSSSEVGENGRSVDQGGGGSPRKKVALTENYELVGVIVHS 1803 +++P L+M+PY M++Q++ V Y L V+VH+ Sbjct: 295 VQYPECLDMQPY----MSQQNTGPLV------------------------YVLYAVLVHA 326 Query: 1804 G-QAHAGHYYSFIKDRRGCGKGKWYKFNDTVI 1834 G H GHY+S++K + +G+WYK +D + Sbjct: 327 GWSCHDGHYFSYVKAQ----EGQWYKMDDAKV 354 >gi|239758075 PREDICTED: similar to deubiquitinating enzyme DUB1 [Homo sapiens] Length = 530 Score = 90.9 bits (224), Expect = 1e-17 Identities = 80/330 (24%), Positives = 144/330 (43%), Gaps = 55/330 (16%) Query: 1517 LPPVDSRSSSGFVGLRNGGATCYMNAVFQQLYMQPGLPESLLSVDDDTDNPDDSVFYQVQ 1576 LP R ++ GL+N G TCY+NA Q L P L +LS + + + Sbjct: 68 LPLSSRRPAAVGAGLQNMGNTCYVNASLQCLTYTPPLANYMLS-REHSQTCHRHKGCMLC 126 Query: 1577 SLFGHLMESKLQYYVPENFWKIFKMWNKELYVREQQDAYEFFTSLID-----------QM 1625 ++ H+ + + P + + + + +Q+DA+EF +D Q+ Sbjct: 127 TMQAHITRA---LHNPGHVIQPSQALAAGFHRGKQEDAHEFLMFTVDAMKKACLPGHKQV 183 Query: 1626 DEYLKKMGRDQIFKNTFQGIYSDQKICKDCPHRYEREEAFMALNLGVTSCQSLEISLDQF 1685 D + K + F G + Q C C + + ++ + L + + QS++ +L+Q Sbjct: 184 DHHSKDT---TLIHQIFGGYWRSQIKCLHCHGISDTFDPYLDIALDIQAAQSVQQALEQL 240 Query: 1686 VRGEVLEGSNAYYCEKCKEKRITVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKYDEQIR 1745 V+ E L G NAY+C C ++ K + + VL++ L RF K + ++ Sbjct: 241 VKPEELNGENAYHCGVCLQRAPASKTLTLHTSAKVLILVLKRF----SDVTGNKIAKNVQ 296 Query: 1746 FPWMLNMEPYTVSGMARQDSSSEVGENGRSVDQGGGGSPRKKVALTENYELVGVIVHSG- 1804 +P L+M+PY M++Q++ V Y L V+VH+G Sbjct: 297 YPECLDMQPY----MSQQNTGPLV------------------------YVLYAVLVHAGW 328 Query: 1805 QAHAGHYYSFIKDRRGCGKGKWYKFNDTVI 1834 H GHY+S++K + +G+WYK +D + Sbjct: 329 SCHNGHYFSYVKAQ----EGQWYKMDDAEV 354 >gi|239742297 PREDICTED: hypothetical protein XP_002342480 [Homo sapiens] Length = 530 Score = 90.9 bits (224), Expect = 1e-17 Identities = 80/330 (24%), Positives = 144/330 (43%), Gaps = 55/330 (16%) Query: 1517 LPPVDSRSSSGFVGLRNGGATCYMNAVFQQLYMQPGLPESLLSVDDDTDNPDDSVFYQVQ 1576 LP R ++ GL+N G TCY+NA Q L P L +LS + + + Sbjct: 68 LPLSSRRPAAVGAGLQNMGNTCYVNASLQCLTYTPPLANYMLS-REHSQTCHRHKGCMLC 126 Query: 1577 SLFGHLMESKLQYYVPENFWKIFKMWNKELYVREQQDAYEFFTSLID-----------QM 1625 ++ H+ + + P + + + + +Q+DA+EF +D Q+ Sbjct: 127 TMQAHITRA---LHNPGHVIQPSQALAAGFHRGKQEDAHEFLMFTVDAMKKACLPGHKQV 183 Query: 1626 DEYLKKMGRDQIFKNTFQGIYSDQKICKDCPHRYEREEAFMALNLGVTSCQSLEISLDQF 1685 D + K + F G + Q C C + + ++ + L + + QS++ +L+Q Sbjct: 184 DHHSKDT---TLIHQIFGGYWRSQIKCLHCHGISDTFDPYLDIALDIQAAQSVQQALEQL 240 Query: 1686 VRGEVLEGSNAYYCEKCKEKRITVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKYDEQIR 1745 V+ E L G NAY+C C ++ K + + VL++ L RF K + ++ Sbjct: 241 VKPEELNGENAYHCGVCLQRAPASKTLTLHTSAKVLILVLKRF----SDVTGNKIAKNVQ 296 Query: 1746 FPWMLNMEPYTVSGMARQDSSSEVGENGRSVDQGGGGSPRKKVALTENYELVGVIVHSG- 1804 +P L+M+PY M++Q++ V Y L V+VH+G Sbjct: 297 YPECLDMQPY----MSQQNTGPLV------------------------YVLYAVLVHAGW 328 Query: 1805 QAHAGHYYSFIKDRRGCGKGKWYKFNDTVI 1834 H GHY+S++K + +G+WYK +D + Sbjct: 329 SCHNGHYFSYVKAQ----EGQWYKMDDAEV 354 >gi|239742287 PREDICTED: hypothetical protein XP_002342475 [Homo sapiens] Length = 530 Score = 90.9 bits (224), Expect = 1e-17 Identities = 80/330 (24%), Positives = 144/330 (43%), Gaps = 55/330 (16%) Query: 1517 LPPVDSRSSSGFVGLRNGGATCYMNAVFQQLYMQPGLPESLLSVDDDTDNPDDSVFYQVQ 1576 LP R ++ GL+N G TCY+NA Q L P L +LS + + + Sbjct: 68 LPLSSRRPAAVGAGLQNMGNTCYVNASLQCLTYTPPLANYMLS-REHSQTCHRHKGCMLC 126 Query: 1577 SLFGHLMESKLQYYVPENFWKIFKMWNKELYVREQQDAYEFFTSLID-----------QM 1625 ++ H+ + + P + + + + +Q+DA+EF +D Q+ Sbjct: 127 TMQAHITRA---LHNPGHVIQPSQALAAGFHRGKQEDAHEFLMFTVDAMKKACLPGHKQV 183 Query: 1626 DEYLKKMGRDQIFKNTFQGIYSDQKICKDCPHRYEREEAFMALNLGVTSCQSLEISLDQF 1685 D + K + F G + Q C C + + ++ + L + + QS++ +L+Q Sbjct: 184 DHHSKDT---TLIHQIFGGYWRSQIKCLHCHGISDTFDPYLDIALDIQAAQSVQQALEQL 240 Query: 1686 VRGEVLEGSNAYYCEKCKEKRITVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKYDEQIR 1745 V+ E L G NAY+C C ++ K + + VL++ L RF K + ++ Sbjct: 241 VKPEELNGENAYHCGVCLQRAPASKTLTLHTSAKVLILVLKRF----SDVTGNKIAKNVQ 296 Query: 1746 FPWMLNMEPYTVSGMARQDSSSEVGENGRSVDQGGGGSPRKKVALTENYELVGVIVHSG- 1804 +P L+M+PY M++Q++ V Y L V+VH+G Sbjct: 297 YPECLDMQPY----MSQQNTGPLV------------------------YVLYAVLVHAGW 328 Query: 1805 QAHAGHYYSFIKDRRGCGKGKWYKFNDTVI 1834 H GHY+S++K + +G+WYK +D + Sbjct: 329 SCHNGHYFSYVKAQ----EGQWYKMDDAEV 354 >gi|169217654 PREDICTED: similar to deubiquitinating enzyme DUB1 [Homo sapiens] Length = 530 Score = 90.5 bits (223), Expect = 2e-17 Identities = 81/327 (24%), Positives = 145/327 (44%), Gaps = 49/327 (14%) Query: 1517 LPPVDSRSSSGFVGLRNGGATCYMNAVFQQLYMQPGLPESLLSVDDDTDNPDDSVFYQVQ 1576 LP R ++ GL+N G TCY+NA Q L P L +LS + + + Sbjct: 68 LPLSSRRPAAVGAGLQNMGNTCYVNASLQCLTYTPPLANYMLS-REHSQTCHRHKGCMLC 126 Query: 1577 SLFGHLMESKLQYYVPENFWKIFKMWNKELYVREQQDAYEFFTSLIDQMDEYLKKMGR-- 1634 ++ H+ + + P + + + + +Q+DA+EF +D M + + Sbjct: 127 TMQAHITRA---LHNPGHVIQPSQALAAGFHRGKQEDAHEFLMFTVDAMKKACLPGHKQA 183 Query: 1635 DQIFKNT------FQGIYSDQKICKDCPHRYEREEAFMALNLGVTSCQSLEISLDQFVRG 1688 D K+T F G + Q C C + + ++ + L + + QS++ +L+Q V+ Sbjct: 184 DHHSKDTTLIHQIFGGYWRSQIKCLHCHGISDTFDPYLDIALDIQAAQSVQQALEQLVKP 243 Query: 1689 EVLEGSNAYYCEKCKEKRITVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKYDEQIRFPW 1748 E L G NAY+C C ++ K + + VL++ L RF K + +++P Sbjct: 244 EELNGENAYHCGVCLQRAPASKTLTLHTSAKVLILVLKRF----SDVTGNKIAKNVQYPE 299 Query: 1749 MLNMEPYTVSGMARQDSSSEVGENGRSVDQGGGGSPRKKVALTENYELVGVIVHSG-QAH 1807 L+M+PY M++Q++ V Y L V+VH+G H Sbjct: 300 CLDMQPY----MSQQNTGPLV------------------------YVLYAVLVHAGWSCH 331 Query: 1808 AGHYYSFIKDRRGCGKGKWYKFNDTVI 1834 GHY+S++K + +G+WYK +D + Sbjct: 332 NGHYFSYVKAQ----EGQWYKMDDAEV 354 >gi|239742282 PREDICTED: hypothetical protein XP_002342474 [Homo sapiens] Length = 530 Score = 90.5 bits (223), Expect = 2e-17 Identities = 81/327 (24%), Positives = 145/327 (44%), Gaps = 49/327 (14%) Query: 1517 LPPVDSRSSSGFVGLRNGGATCYMNAVFQQLYMQPGLPESLLSVDDDTDNPDDSVFYQVQ 1576 LP R ++ GL+N G TCY+NA Q L P L +LS + + + Sbjct: 68 LPLSSRRPAAVGAGLQNMGNTCYVNASLQCLTYTPPLANYMLS-REHSQTCHRHKGCMLC 126 Query: 1577 SLFGHLMESKLQYYVPENFWKIFKMWNKELYVREQQDAYEFFTSLIDQMDEYLKKMGR-- 1634 ++ H+ + + P + + + + +Q+DA+EF +D M + + Sbjct: 127 TMQAHITRA---LHNPGHVIQPSQALAAGFHRGKQEDAHEFLMFTVDAMKKACLPGHKQV 183 Query: 1635 DQIFKNT------FQGIYSDQKICKDCPHRYEREEAFMALNLGVTSCQSLEISLDQFVRG 1688 D K+T F G + Q C C + + ++ + L + + QS++ +L+Q V+ Sbjct: 184 DHPSKDTTLIHQIFGGYWRSQIKCLHCHGISDTFDPYLDIALDIQAAQSVQQALEQLVKP 243 Query: 1689 EVLEGSNAYYCEKCKEKRITVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKYDEQIRFPW 1748 E L G NAY+C C ++ K + + VL++ L RF K + +++P Sbjct: 244 EELNGENAYHCGVCLQRAPASKTLTLHTSAKVLILVLKRF----SDVTGNKIAKNVQYPE 299 Query: 1749 MLNMEPYTVSGMARQDSSSEVGENGRSVDQGGGGSPRKKVALTENYELVGVIVHSG-QAH 1807 L+M+PY M++Q++ V Y L V+VH+G H Sbjct: 300 CLDMQPY----MSQQNTGPLV------------------------YVLYAVLVHAGWSCH 331 Query: 1808 AGHYYSFIKDRRGCGKGKWYKFNDTVI 1834 GHY+S++K + +G+WYK +D + Sbjct: 332 NGHYFSYVKAQ----EGQWYKMDDAEV 354 >gi|157785653 ubiquitin specific peptidase 17 [Homo sapiens] Length = 530 Score = 90.1 bits (222), Expect = 2e-17 Identities = 79/330 (23%), Positives = 144/330 (43%), Gaps = 55/330 (16%) Query: 1517 LPPVDSRSSSGFVGLRNGGATCYMNAVFQQLYMQPGLPESLLSVDDDTDNPDDSVFYQVQ 1576 LP R ++ GL+N G TCY+NA + L P L +LS + + + Sbjct: 68 LPLSSRRPAAVGAGLQNMGNTCYVNASLEWLTYTPPLANYMLS-REHSQTCHRHKGCMLC 126 Query: 1577 SLFGHLMESKLQYYVPENFWKIFKMWNKELYVREQQDAYEFFTSLID-----------QM 1625 ++ H+ + + P + + + + +Q+DA+EF +D Q+ Sbjct: 127 TMQAHITRA---LHNPGHVIQPSQALAAGFHRGKQEDAHEFLMFTVDAMKKACLPGHKQV 183 Query: 1626 DEYLKKMGRDQIFKNTFQGIYSDQKICKDCPHRYEREEAFMALNLGVTSCQSLEISLDQF 1685 D + K + F G + Q C C + + ++ + L + + QS++ +L+Q Sbjct: 184 DHHSKDT---TLIHQIFGGYWRSQIKCLHCHGISDTFDPYLDIALDIQAAQSVQQALEQL 240 Query: 1686 VRGEVLEGSNAYYCEKCKEKRITVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKYDEQIR 1745 V+ E L G NAY+C C ++ K + + VL++ L RF K + ++ Sbjct: 241 VKPEELNGENAYHCGVCLQRAPASKTLTLHTSAKVLILVLKRF----SDVTGNKIAKNVQ 296 Query: 1746 FPWMLNMEPYTVSGMARQDSSSEVGENGRSVDQGGGGSPRKKVALTENYELVGVIVHSG- 1804 +P L+M+PY M++Q++ V Y L V+VH+G Sbjct: 297 YPECLDMQPY----MSQQNTGPLV------------------------YVLYAVLVHAGW 328 Query: 1805 QAHAGHYYSFIKDRRGCGKGKWYKFNDTVI 1834 H GHY+S++K + +G+WYK +D + Sbjct: 329 SCHNGHYFSYVKAQ----EGQWYKMDDAEV 354 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.319 0.133 0.387 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 88,431,910 Number of Sequences: 37866 Number of extensions: 3868856 Number of successful extensions: 15413 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 115 Number of HSP's successfully gapped in prelim test: 32 Number of HSP's that attempted gapping in prelim test: 14049 Number of HSP's gapped (non-prelim): 876 length of query: 2460 length of database: 18,247,518 effective HSP length: 119 effective length of query: 2341 effective length of database: 13,741,464 effective search space: 32168767224 effective search space used: 32168767224 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 71 (32.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.