Guide to the Human Genome
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Search of human proteins with 149192845

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|149192845 ubiquitin specific protease 24 [Homo sapiens]
         (2460 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|149192845 ubiquitin specific protease 24 [Homo sapiens]           4873   0.0  
gi|145309309 ubiquitin specific protease 9, X-linked isoform 3 [...   960   0.0  
gi|145309311 ubiquitin specific protease 9, X-linked isoform 4 [...   958   0.0  
gi|74319833 ubiquitin specific protease 9, Y-linked [Homo sapiens]    942   0.0  
gi|110347427 ubiquitin specific protease 34 [Homo sapiens]            248   4e-65
gi|71774197 ubiquitin specific protease 47 [Homo sapiens]             146   2e-34
gi|76257392 ubiquitin specific protease 48 isoform b [Homo sapiens]   143   2e-33
gi|52630449 ubiquitin specific protease 48 isoform a [Homo sapiens]   143   2e-33
gi|150378533 ubiquitin specific peptidase 7 [Homo sapiens]            119   5e-26
gi|41055953 ubiquitin thioesterase 40 [Homo sapiens]                  115   7e-25
gi|122114651 ubiquitin specific peptidase 36 [Homo sapiens]           103   2e-21
gi|197116355 ubiquitin specific peptidase 46 isoform 2 [Homo sap...   101   8e-21
gi|31377709 ubiquitin specific peptidase 46 isoform 1 [Homo sapi...   101   8e-21
gi|32698815 ubiquitin thiolesterase 12 [Homo sapiens]                 100   2e-20
gi|190684694 ubiquitin specific peptidase 8 [Homo sapiens]             97   1e-19
gi|190684692 ubiquitin specific peptidase 8 [Homo sapiens]             97   1e-19
gi|190684690 ubiquitin specific peptidase 8 [Homo sapiens]             97   1e-19
gi|79750944 ubiquitin specific peptidase 42 [Homo sapiens]             97   3e-19
gi|239757637 PREDICTED: ubiquitin specific peptidase 41 [Homo sa...    96   4e-19
gi|169215723 PREDICTED: ubiquitin specific peptidase 41 [Homo sa...    96   6e-19
gi|239746654 PREDICTED: ubiquitin specific protease 41 [Homo sap...    96   6e-19
gi|32313610 ubiquitin specific protease 18 [Homo sapiens]              96   6e-19
gi|239742276 PREDICTED: hypothetical protein XP_002342471 [Homo ...    92   5e-18
gi|153792150 deubiquitinating enzyme 3 [Homo sapiens]                  92   8e-18
gi|239758075 PREDICTED: similar to deubiquitinating enzyme DUB1 ...    91   1e-17
gi|239742297 PREDICTED: hypothetical protein XP_002342480 [Homo ...    91   1e-17
gi|239742287 PREDICTED: hypothetical protein XP_002342475 [Homo ...    91   1e-17
gi|169217654 PREDICTED: similar to deubiquitinating enzyme DUB1 ...    91   2e-17
gi|239742282 PREDICTED: hypothetical protein XP_002342474 [Homo ...    91   2e-17
gi|157785653 ubiquitin specific peptidase 17 [Homo sapiens]            90   2e-17

>gi|149192845 ubiquitin specific protease 24 [Homo sapiens]
          Length = 2460

 Score = 4873 bits (12639), Expect = 0.0
 Identities = 2460/2460 (100%), Positives = 2460/2460 (100%)

Query: 1    MTTLLCMGFSDPATIRKALRLAKNDINEAVALLTNERPGLDYGGYEPMDSGGLSESDENC 60
            MTTLLCMGFSDPATIRKALRLAKNDINEAVALLTNERPGLDYGGYEPMDSGGLSESDENC
Sbjct: 1    MTTLLCMGFSDPATIRKALRLAKNDINEAVALLTNERPGLDYGGYEPMDSGGLSESDENC 60

Query: 61   RRFMDRCMPEAFKKLLTSSAVHKWGTEIHEGIYNMLMLLIELVAERIKQDPIPTGLLGVL 120
            RRFMDRCMPEAFKKLLTSSAVHKWGTEIHEGIYNMLMLLIELVAERIKQDPIPTGLLGVL
Sbjct: 61   RRFMDRCMPEAFKKLLTSSAVHKWGTEIHEGIYNMLMLLIELVAERIKQDPIPTGLLGVL 120

Query: 121  TMAFNPDNEYHFKNRMKVSQRNWAEVFGEGNMFAVSPVSTFQKEPHGWVVDLVNKFGELG 180
            TMAFNPDNEYHFKNRMKVSQRNWAEVFGEGNMFAVSPVSTFQKEPHGWVVDLVNKFGELG
Sbjct: 121  TMAFNPDNEYHFKNRMKVSQRNWAEVFGEGNMFAVSPVSTFQKEPHGWVVDLVNKFGELG 180

Query: 181  GFAAIQAKLHSEDIELGAVSALIQPLGVCAEYLNSSVVQPMLDPVILTTIQDVRSVEEKD 240
            GFAAIQAKLHSEDIELGAVSALIQPLGVCAEYLNSSVVQPMLDPVILTTIQDVRSVEEKD
Sbjct: 181  GFAAIQAKLHSEDIELGAVSALIQPLGVCAEYLNSSVVQPMLDPVILTTIQDVRSVEEKD 240

Query: 241  LKDKRLVSIPELLSAVKLLCMRFQPDLVTIVDDLRLDILLRMLKSPHFSAKMNSLKEVTK 300
            LKDKRLVSIPELLSAVKLLCMRFQPDLVTIVDDLRLDILLRMLKSPHFSAKMNSLKEVTK
Sbjct: 241  LKDKRLVSIPELLSAVKLLCMRFQPDLVTIVDDLRLDILLRMLKSPHFSAKMNSLKEVTK 300

Query: 301  LIEDSTLSKSVKNAIDTDRLLDWLVENSVLSIALEGNIDQAQYCDRIKGIIELLGSKLSL 360
            LIEDSTLSKSVKNAIDTDRLLDWLVENSVLSIALEGNIDQAQYCDRIKGIIELLGSKLSL
Sbjct: 301  LIEDSTLSKSVKNAIDTDRLLDWLVENSVLSIALEGNIDQAQYCDRIKGIIELLGSKLSL 360

Query: 361  DELTKIWKIQSGQSSTVIENIHTIIAAAAVKFNSDQLNHLFVLIQKVLDVLWELAHLPTL 420
            DELTKIWKIQSGQSSTVIENIHTIIAAAAVKFNSDQLNHLFVLIQKVLDVLWELAHLPTL
Sbjct: 361  DELTKIWKIQSGQSSTVIENIHTIIAAAAVKFNSDQLNHLFVLIQKVLDVLWELAHLPTL 420

Query: 421  PSSLIQQALEEHLTILSDAYAVKEAIKRSYIIKCIEDIKRSSQLNNPQFVWVVPALRQLH 480
            PSSLIQQALEEHLTILSDAYAVKEAIKRSYIIKCIEDIKRSSQLNNPQFVWVVPALRQLH
Sbjct: 421  PSSLIQQALEEHLTILSDAYAVKEAIKRSYIIKCIEDIKRSSQLNNPQFVWVVPALRQLH 480

Query: 481  EITRSFIKQTYQKQDKSIIQDLKKNFEIVKLVTGSLIACHRLAAAVAGPGGLSGSTLVDG 540
            EITRSFIKQTYQKQDKSIIQDLKKNFEIVKLVTGSLIACHRLAAAVAGPGGLSGSTLVDG
Sbjct: 481  EITRSFIKQTYQKQDKSIIQDLKKNFEIVKLVTGSLIACHRLAAAVAGPGGLSGSTLVDG 540

Query: 541  RYTYREYLEAHLKFLAFFLQEATLYLGWNRAKEIWECLVTGQDVCELDREMCFEWFTKGQ 600
            RYTYREYLEAHLKFLAFFLQEATLYLGWNRAKEIWECLVTGQDVCELDREMCFEWFTKGQ
Sbjct: 541  RYTYREYLEAHLKFLAFFLQEATLYLGWNRAKEIWECLVTGQDVCELDREMCFEWFTKGQ 600

Query: 601  HDLESDVQQQLFKEKILKLESYEITMNGFNLFKTFFENVNLCDHRLKRQGAQLYVEKLEL 660
            HDLESDVQQQLFKEKILKLESYEITMNGFNLFKTFFENVNLCDHRLKRQGAQLYVEKLEL
Sbjct: 601  HDLESDVQQQLFKEKILKLESYEITMNGFNLFKTFFENVNLCDHRLKRQGAQLYVEKLEL 660

Query: 661  IGMDFIWKIAMESPDEEIANEAIQLIINYSYINLNPRLKKDSVSLHKKFIADCYTRLEAA 720
            IGMDFIWKIAMESPDEEIANEAIQLIINYSYINLNPRLKKDSVSLHKKFIADCYTRLEAA
Sbjct: 661  IGMDFIWKIAMESPDEEIANEAIQLIINYSYINLNPRLKKDSVSLHKKFIADCYTRLEAA 720

Query: 721  SSALGGPTLTHAVTRATKMLTATAMPTVATSVQSPYRSTKLVIIERLLLLAERYVITIED 780
            SSALGGPTLTHAVTRATKMLTATAMPTVATSVQSPYRSTKLVIIERLLLLAERYVITIED
Sbjct: 721  SSALGGPTLTHAVTRATKMLTATAMPTVATSVQSPYRSTKLVIIERLLLLAERYVITIED 780

Query: 781  FYSVPRTILPHGASFHGHLLTLNVTYESTKDTFTVEAHSNETIGSVRWKIAKQLCSPVDN 840
            FYSVPRTILPHGASFHGHLLTLNVTYESTKDTFTVEAHSNETIGSVRWKIAKQLCSPVDN
Sbjct: 781  FYSVPRTILPHGASFHGHLLTLNVTYESTKDTFTVEAHSNETIGSVRWKIAKQLCSPVDN 840

Query: 841  IQIFTNDSLLTVNKDQKLLHQLGFSDEQILTVKTSGSGTPSGSSADSSTSSSSSSSGVFS 900
            IQIFTNDSLLTVNKDQKLLHQLGFSDEQILTVKTSGSGTPSGSSADSSTSSSSSSSGVFS
Sbjct: 841  IQIFTNDSLLTVNKDQKLLHQLGFSDEQILTVKTSGSGTPSGSSADSSTSSSSSSSGVFS 900

Query: 901  SSYAMEQEKSLPGVVMALVCNVFDMLYQLANLEEPRITLRVRKLLLLIPTDPAIQEALDQ 960
            SSYAMEQEKSLPGVVMALVCNVFDMLYQLANLEEPRITLRVRKLLLLIPTDPAIQEALDQ
Sbjct: 901  SSYAMEQEKSLPGVVMALVCNVFDMLYQLANLEEPRITLRVRKLLLLIPTDPAIQEALDQ 960

Query: 961  LDSLGRKKTLLSESSSQSSKSPSLSSKQQHQPSASSILESLFRSFAPGMSTFRVLYNLEV 1020
            LDSLGRKKTLLSESSSQSSKSPSLSSKQQHQPSASSILESLFRSFAPGMSTFRVLYNLEV
Sbjct: 961  LDSLGRKKTLLSESSSQSSKSPSLSSKQQHQPSASSILESLFRSFAPGMSTFRVLYNLEV 1020

Query: 1021 LSSKLMPTADDDMARSCAKSFCENFLKAGGLSLVVNVMQRDSIPSEVDYETRQGVYSICL 1080
            LSSKLMPTADDDMARSCAKSFCENFLKAGGLSLVVNVMQRDSIPSEVDYETRQGVYSICL
Sbjct: 1021 LSSKLMPTADDDMARSCAKSFCENFLKAGGLSLVVNVMQRDSIPSEVDYETRQGVYSICL 1080

Query: 1081 QLARFLLVGQTMPTLLDEDLTKDGIEALSSRPFRNVSRQTSRQMSLCGTPEKSSYRQLSV 1140
            QLARFLLVGQTMPTLLDEDLTKDGIEALSSRPFRNVSRQTSRQMSLCGTPEKSSYRQLSV
Sbjct: 1081 QLARFLLVGQTMPTLLDEDLTKDGIEALSSRPFRNVSRQTSRQMSLCGTPEKSSYRQLSV 1140

Query: 1141 SDRSSIRVEEIIPAARVAIQTMEVSDFTSTVACFMRLSWAAAAGRLDLVGSSQPIKESNS 1200
            SDRSSIRVEEIIPAARVAIQTMEVSDFTSTVACFMRLSWAAAAGRLDLVGSSQPIKESNS
Sbjct: 1141 SDRSSIRVEEIIPAARVAIQTMEVSDFTSTVACFMRLSWAAAAGRLDLVGSSQPIKESNS 1200

Query: 1201 LCPAGIRNRLSSSGSNCSSGSEGEPVALHAGICVRQQSVSTKDSLIAGEALSLLVTCLQL 1260
            LCPAGIRNRLSSSGSNCSSGSEGEPVALHAGICVRQQSVSTKDSLIAGEALSLLVTCLQL
Sbjct: 1201 LCPAGIRNRLSSSGSNCSSGSEGEPVALHAGICVRQQSVSTKDSLIAGEALSLLVTCLQL 1260

Query: 1261 RSQQLASFYNLPCVADFIIDILLGSPSAEIRRVACDQLYTLSQTDTSAHPDVQKPNQFLL 1320
            RSQQLASFYNLPCVADFIIDILLGSPSAEIRRVACDQLYTLSQTDTSAHPDVQKPNQFLL
Sbjct: 1261 RSQQLASFYNLPCVADFIIDILLGSPSAEIRRVACDQLYTLSQTDTSAHPDVQKPNQFLL 1320

Query: 1321 GVILTAQLPLWSPTSIMRGVNQRLLSQCMEYFDLRCQLLDDLTTSEMEQLRISPATMLED 1380
            GVILTAQLPLWSPTSIMRGVNQRLLSQCMEYFDLRCQLLDDLTTSEMEQLRISPATMLED
Sbjct: 1321 GVILTAQLPLWSPTSIMRGVNQRLLSQCMEYFDLRCQLLDDLTTSEMEQLRISPATMLED 1380

Query: 1381 EITWLDNFEPNRTAECETSEADNILLAGHLRLIKTLLSLCGAEKEMLGSSLIKPLLDDFL 1440
            EITWLDNFEPNRTAECETSEADNILLAGHLRLIKTLLSLCGAEKEMLGSSLIKPLLDDFL
Sbjct: 1381 EITWLDNFEPNRTAECETSEADNILLAGHLRLIKTLLSLCGAEKEMLGSSLIKPLLDDFL 1440

Query: 1441 FRASRIILNSHSPAGSAAISQQDFHPKCSTANSRLAAYEVLVMLADSSPSNLQIIIKELL 1500
            FRASRIILNSHSPAGSAAISQQDFHPKCSTANSRLAAYEVLVMLADSSPSNLQIIIKELL
Sbjct: 1441 FRASRIILNSHSPAGSAAISQQDFHPKCSTANSRLAAYEVLVMLADSSPSNLQIIIKELL 1500

Query: 1501 SMHHQPDPALTKEFDYLPPVDSRSSSGFVGLRNGGATCYMNAVFQQLYMQPGLPESLLSV 1560
            SMHHQPDPALTKEFDYLPPVDSRSSSGFVGLRNGGATCYMNAVFQQLYMQPGLPESLLSV
Sbjct: 1501 SMHHQPDPALTKEFDYLPPVDSRSSSGFVGLRNGGATCYMNAVFQQLYMQPGLPESLLSV 1560

Query: 1561 DDDTDNPDDSVFYQVQSLFGHLMESKLQYYVPENFWKIFKMWNKELYVREQQDAYEFFTS 1620
            DDDTDNPDDSVFYQVQSLFGHLMESKLQYYVPENFWKIFKMWNKELYVREQQDAYEFFTS
Sbjct: 1561 DDDTDNPDDSVFYQVQSLFGHLMESKLQYYVPENFWKIFKMWNKELYVREQQDAYEFFTS 1620

Query: 1621 LIDQMDEYLKKMGRDQIFKNTFQGIYSDQKICKDCPHRYEREEAFMALNLGVTSCQSLEI 1680
            LIDQMDEYLKKMGRDQIFKNTFQGIYSDQKICKDCPHRYEREEAFMALNLGVTSCQSLEI
Sbjct: 1621 LIDQMDEYLKKMGRDQIFKNTFQGIYSDQKICKDCPHRYEREEAFMALNLGVTSCQSLEI 1680

Query: 1681 SLDQFVRGEVLEGSNAYYCEKCKEKRITVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKY 1740
            SLDQFVRGEVLEGSNAYYCEKCKEKRITVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKY
Sbjct: 1681 SLDQFVRGEVLEGSNAYYCEKCKEKRITVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKY 1740

Query: 1741 DEQIRFPWMLNMEPYTVSGMARQDSSSEVGENGRSVDQGGGGSPRKKVALTENYELVGVI 1800
            DEQIRFPWMLNMEPYTVSGMARQDSSSEVGENGRSVDQGGGGSPRKKVALTENYELVGVI
Sbjct: 1741 DEQIRFPWMLNMEPYTVSGMARQDSSSEVGENGRSVDQGGGGSPRKKVALTENYELVGVI 1800

Query: 1801 VHSGQAHAGHYYSFIKDRRGCGKGKWYKFNDTVIEEFDLNDETLEYECFGGEYRPKVYDQ 1860
            VHSGQAHAGHYYSFIKDRRGCGKGKWYKFNDTVIEEFDLNDETLEYECFGGEYRPKVYDQ
Sbjct: 1801 VHSGQAHAGHYYSFIKDRRGCGKGKWYKFNDTVIEEFDLNDETLEYECFGGEYRPKVYDQ 1860

Query: 1861 TNPYTDVRRRYWNAYMLFYQRVSDQNSPVLPKKSRVSVVRQEAEDLSLSAPSSPEISPQS 1920
            TNPYTDVRRRYWNAYMLFYQRVSDQNSPVLPKKSRVSVVRQEAEDLSLSAPSSPEISPQS
Sbjct: 1861 TNPYTDVRRRYWNAYMLFYQRVSDQNSPVLPKKSRVSVVRQEAEDLSLSAPSSPEISPQS 1920

Query: 1921 SPRPHRPNNDRLSILTKLVKKGEKKGLFVEKMPARIYQMVRDENLKFMKNRDVYSSDYFS 1980
            SPRPHRPNNDRLSILTKLVKKGEKKGLFVEKMPARIYQMVRDENLKFMKNRDVYSSDYFS
Sbjct: 1921 SPRPHRPNNDRLSILTKLVKKGEKKGLFVEKMPARIYQMVRDENLKFMKNRDVYSSDYFS 1980

Query: 1981 FVLSLASLNATKLKHPYYPCMAKVSLQLAIQFLFQTYLRTKKKLRVDTEEWIATIEALLS 2040
            FVLSLASLNATKLKHPYYPCMAKVSLQLAIQFLFQTYLRTKKKLRVDTEEWIATIEALLS
Sbjct: 1981 FVLSLASLNATKLKHPYYPCMAKVSLQLAIQFLFQTYLRTKKKLRVDTEEWIATIEALLS 2040

Query: 2041 KSFDACQWLVEYFISSEGRELIKIFLLECNVREVRVAVATILEKTLDSALFYQDKLKSLH 2100
            KSFDACQWLVEYFISSEGRELIKIFLLECNVREVRVAVATILEKTLDSALFYQDKLKSLH
Sbjct: 2041 KSFDACQWLVEYFISSEGRELIKIFLLECNVREVRVAVATILEKTLDSALFYQDKLKSLH 2100

Query: 2101 QLLEVLLALLDKDVPENCKNCAQYFFLFNTFVQKQGIRAGDLLLRHSALRHMISFLLGAS 2160
            QLLEVLLALLDKDVPENCKNCAQYFFLFNTFVQKQGIRAGDLLLRHSALRHMISFLLGAS
Sbjct: 2101 QLLEVLLALLDKDVPENCKNCAQYFFLFNTFVQKQGIRAGDLLLRHSALRHMISFLLGAS 2160

Query: 2161 RQNNQIRRWSSAQAREFGNLHNTVALLVLHSDVSSQRNVAPGIFKQRPPISIAPSSPLLP 2220
            RQNNQIRRWSSAQAREFGNLHNTVALLVLHSDVSSQRNVAPGIFKQRPPISIAPSSPLLP
Sbjct: 2161 RQNNQIRRWSSAQAREFGNLHNTVALLVLHSDVSSQRNVAPGIFKQRPPISIAPSSPLLP 2220

Query: 2221 LHEEVEALLFMSEGKPYLLEVMFALRELTGSLLALIEMVVYCCFCNEHFSFTMLHFIKNQ 2280
            LHEEVEALLFMSEGKPYLLEVMFALRELTGSLLALIEMVVYCCFCNEHFSFTMLHFIKNQ
Sbjct: 2221 LHEEVEALLFMSEGKPYLLEVMFALRELTGSLLALIEMVVYCCFCNEHFSFTMLHFIKNQ 2280

Query: 2281 LETAPPHELKNTFQLLHEILVIEDPIQVERVKFVFETENGLLALMHHSNHVDSSRCYQCV 2340
            LETAPPHELKNTFQLLHEILVIEDPIQVERVKFVFETENGLLALMHHSNHVDSSRCYQCV
Sbjct: 2281 LETAPPHELKNTFQLLHEILVIEDPIQVERVKFVFETENGLLALMHHSNHVDSSRCYQCV 2340

Query: 2341 KFLVTLAQKCPAAKEYFKENSHHWSWAVQWLQKKMSEHYWTPQSNVSNETSTGKTFQRTI 2400
            KFLVTLAQKCPAAKEYFKENSHHWSWAVQWLQKKMSEHYWTPQSNVSNETSTGKTFQRTI
Sbjct: 2341 KFLVTLAQKCPAAKEYFKENSHHWSWAVQWLQKKMSEHYWTPQSNVSNETSTGKTFQRTI 2400

Query: 2401 SAQDTLAYATALLNEKEQSGSSNGSESSPANENGDRHLQQGSESPMMIGELRSDLDDVDP 2460
            SAQDTLAYATALLNEKEQSGSSNGSESSPANENGDRHLQQGSESPMMIGELRSDLDDVDP
Sbjct: 2401 SAQDTLAYATALLNEKEQSGSSNGSESSPANENGDRHLQQGSESPMMIGELRSDLDDVDP 2460


>gi|145309309 ubiquitin specific protease 9, X-linked isoform 3 [Homo
            sapiens]
          Length = 2570

 Score =  960 bits (2482), Expect = 0.0
 Identities = 769/2593 (29%), Positives = 1228/2593 (47%), Gaps = 392/2593 (15%)

Query: 52   GLSESDENCRRFMDRCMPEAFKKLLTSSAVHKWGTEIHEGIYNMLMLLIELVAERIKQDP 111
            GL    E C+RF    +  +F K+LT  AV  W  EIH  I N    L+EL   ++ QD 
Sbjct: 108  GLDVKSEACQRFFRDGLTISFTKILTDEAVSGWKFEIHRCIINNTHRLVELCVAKLSQDW 167

Query: 112  IPTGLLGVLTMAFNPDNEYHFKNRMKVSQRNWAEV-FGEGNMFAVSPVSTFQKEPHGWVV 170
             P  LL +L MA NP  ++H  N  +  +   + V   E  +FA SP     + P GW+V
Sbjct: 168  FP--LLELLAMALNPHCKFHIYNGTRPCESVSSSVQLPEDELFARSP---DPRSPKGWLV 222

Query: 171  DLVNKFGELGGFAAIQAK-LHSEDIELGAVSALIQPLGVCAEYLNSSVVQPMLDPVILTT 229
            DL+NKFG L GF  +  + ++   + +  ++ALI+P G C E+L    V+    P+I   
Sbjct: 223  DLLNKFGTLNGFQILHDRFINGSALNVQIIAALIKPFGQCYEFLTLHTVKKYFLPIIEMV 282

Query: 230  IQDVRSVEEKDLK-----DKRLVSIPELLSAVKLLCMRF--QPDLVTIVDDLRLDILLRM 282
             Q + ++ +++LK     + +  ++  ++ ++K L  R   Q + V  ++  RL ++LR+
Sbjct: 283  PQFLENLTDEELKKEAKNEAKNDALSMIIKSLKNLASRVPGQEETVKNLEIFRLKMILRL 342

Query: 283  LKSPHFSAKMNSLKEVTKLIEDSTL------SKSVKNAIDTDRLLDWLVENSVLSIALEG 336
            L+   F+ KMN+L EV K+I   +       +   +  +  +R+ +W+ +N++LSI L  
Sbjct: 343  LQISSFNGKMNALNEVNKVISSVSYYTHRHGNPEEEEWLTAERMAEWIQQNNILSIVLRD 402

Query: 337  NIDQAQYCDRIKGIIELL--GSKLSLDELTKIWKIQSGQSSTVIENIHTIIAAAAVKFNS 394
            ++ Q QY ++++ I+  +     L+L +L  IW  Q+G+   +++N+H ++A  A  F+ 
Sbjct: 403  SLHQPQYVEKLEKILRFVIKEKALTLQDLDNIWAAQAGKHEAIVKNVHDLLAKLAWDFSP 462

Query: 395  DQLNHLF--------------------------------VLIQKVLDVLWELAHLPTLPS 422
            +QL+HLF                                V+  KVL++LW LAH   +P 
Sbjct: 463  EQLDHLFDCFKASWTNASKKQREKLLELIRRLAEDDKDGVMAHKVLNLLWNLAHSDDVPV 522

Query: 423  SLIQQALEEHLTILSDAYAV-KEAIKRSYIIKCIEDIKRSSQLNNPQFVWVVPALRQLHE 481
             ++  AL  H+ IL  + +  ++  K  +I + IE+++ + +       WV+PAL+Q+ E
Sbjct: 523  DIMDLALSAHIKILDYSCSQDRDTQKIQWIDRFIEELRTNDK-------WVIPALKQIRE 575

Query: 482  ITRSF------IKQTYQKQD----KSIIQDLKKNFEIVKLVTGSLIA-CHRLAAAVAGPG 530
            I   F      + QT +         +I  L+ N  +V LV  +L      +        
Sbjct: 576  ICSLFGEAPQNLSQTQRSPHVFYRHDLINQLQHNHALVTLVAENLATYMESMRLYARDHE 635

Query: 531  GLSGSTL-VDGRYTYREYLEAHLKFLAFFLQEATLYLGWNRAKEIWECLVTGQDVCELDR 589
                 T+ +  RY++ + ++  L FL F L++  L+L   +AK+IW+CL     V   DR
Sbjct: 636  DYDPQTVRLGSRYSHVQEVQERLNFLRFLLKDGQLWLCAPQAKQIWKCLAENA-VYLCDR 694

Query: 590  EMCFEWFTK---GQHDLESDVQQQLFKEKILKLESYEITMNGFNLFKTFFENVNLCDHRL 646
            E CF+W++K    + DL+ D+ +  F+  +L+L+   +T NG   F+ FF+ VN  + +L
Sbjct: 695  EACFKWYSKLMGDEPDLDPDINKDFFESNVLQLDPSLLTENGMKCFERFFKAVNCREGKL 754

Query: 647  KRQGAQLYVEKLELIGMDFIWKIAMESPDEEIANEAIQLIINYSYINLNPRLKKDSVSLH 706
              +     ++ LELIG+D++W++ ++S D +IA+ AI L +   Y NL PRL+ + V +H
Sbjct: 755  VAKRRAYMMDDLELIGLDYLWRVVIQSND-DIASRAIDL-LKEIYTNLGPRLQVNQVVIH 812

Query: 707  KKFIADCYTRLEAASSALGGPTLTHAVTRATKMLTATAMPTVATSVQSPYRSTKLVIIER 766
            + FI  C+ RL+A+   L        V    K        +V  + Q   R      + R
Sbjct: 813  EDFIQSCFDRLKASYDTL-------CVLDGDK-------DSVNCARQEAVR------MVR 852

Query: 767  LLLLAERYVITIEDFYSVPRTILPHGASFHGHLLTLNVTYES---TKDTFTVEAHSNETI 823
            +L +   Y+   +  Y   RTILP   +F G  L+  V + +     D   V +H+N+TI
Sbjct: 853  VLTVLREYINECDSDYHEERTILPMSRAFRGKHLSFVVRFPNQGRQVDDLEVWSHTNDTI 912

Query: 824  GSVRWKIAKQLCSPV--DNIQIFTNDSLLTVNKDQKLLHQLGFSDEQILTVKTSGSGTPS 881
            GSVR  I  ++ + V    I++F    L+    D+KL+ QL   D+ ++T K +   +  
Sbjct: 913  GSVRRCILNRIKANVAHTKIELFVGGELIDPADDRKLIGQLNLKDKSLITAKLTQISSNM 972

Query: 882  GSSADSSTSSSSSSSGVFSSSYA----MEQEKSLPGVVMALVCNVFDMLYQLA----NLE 933
             SS DSS+ SS+ S G   + Y+     E E  LPGV+M+L       L+Q+A    +L 
Sbjct: 973  PSSPDSSSDSSTGSPGNHGNHYSDGPNPEVESCLPGVIMSLHPRYISFLWQVADLGSSLN 1032

Query: 934  EPRITLRVRKLLLLIPTDPAIQEALDQLDSLGRKKTLLSESSSQSSKSPSLSSKQQHQPS 993
             P +    R L+ L+P D    E L       R   L      +SS SPS          
Sbjct: 1033 MPPLRDGARVLMKLMPPDSTTIEKL-------RAICLDHAKLGESSLSPS---------- 1075

Query: 994  ASSILESLFRSFAPGMSTFRVLYNLEVLSSKLMPT----ADDDMARSCAKSFCENFLKAG 1049
                L+SLF  F P  S  +VLY  EV+ + LMP     ADD      +  F  +FLK+G
Sbjct: 1076 ----LDSLF--FGPSAS--QVLYLTEVVYALLMPAGAPLADD------SSDFQFHFLKSG 1121

Query: 1050 GLSLVVNVMQRDSIPSEVDYETRQGVYSICLQLARFLL--VGQTMPTLLDEDLTKDGIEA 1107
            GL LV++++ R++     D ETR+G Y   L++A+ LL  +G      + E   + G+E 
Sbjct: 1122 GLPLVLSMLTRNNFLPNADMETRRGAYLNALKIAKLLLTAIGYGHVRAVAE-ACQPGVEG 1180

Query: 1108 LSSRPFRNVSRQTSRQMSLCGTPEKSSYRQLSVSDRSSIRVEEIIPAARVAIQTMEVSDF 1167
            ++  P   +++ T  Q  +  +  +S     + S    +R   +  A +++ +       
Sbjct: 1181 VN--PMTQINQVTHDQAVVLQSALQSI---PNPSSECMLRNVSVRLAQQISDEASRYMPD 1235

Query: 1168 TSTVACFMRLSWAAAAGRLDLVGSSQPIKESNSLCPAGIRNRLSSSGSNCSSGSEGEPVA 1227
               +    ++ WA+  G L LV S                  ++      ++G+E +   
Sbjct: 1236 ICVIRAIQKIIWASGCGSLQLVFSP--------------NEEITKIYEKTNAGNEPD--- 1278

Query: 1228 LHAGICVRQQSVSTKDSLIAGEALSLLVTCLQLRSQQLASFYNLPCVADFIIDILLGSPS 1287
                          +D  +  EAL ++  C  L    L +         FIID+LL   S
Sbjct: 1279 -------------LEDEQVCCEALEVMTLCFALIPTALDALSKEKAWQTFIIDLLLHCHS 1325

Query: 1288 AEIRRVACDQLYTLSQTDTSAHPDVQKPNQFLLGVILTAQLPLWSPTSIMRGVNQRLLSQ 1347
              +R+VA +Q + +       H    +P  F + ++ T          ++    +     
Sbjct: 1326 KTVRQVAQEQFFLMCTRCCMGH----RPLLFFITLLFT----------VLGSTARERAKH 1371

Query: 1348 CMEYFDLRCQLLDDLTTSEMEQLRISPATMLEDEITWLDNFEPNRTAECETSEADNILLA 1407
              +YF L   LL+    S +     +   +L +EI WL     +     ET   +  +L 
Sbjct: 1372 SGDYFTLLRHLLNYAYNSNINV--PNAEVLLNNEIDWLKRIRDDVKRTGETG-IEETILE 1428

Query: 1408 GHLRLIKTLLSLCGAEK------EMLGSSLIKPLLDDFLFRASRIIL----NSHSPAGSA 1457
            GHL + K LL+   +EK      E  G++LIK L+DDF+F AS + L    N   PA  A
Sbjct: 1429 GHLGVTKELLAFQTSEKKFHIGCEKGGANLIKELIDDFIFPASNVYLQYMRNGELPAEQA 1488

Query: 1458 AISQQDFHPKCSTANSRLAAYEVLVMLADSSPSNLQIIIKELLSMHHQPDPALT----KE 1513
                    P C +  +  A +E+LV LA     NL+ I+  L  M++      T     E
Sbjct: 1489 I-------PVCGSPPTINAGFELLVALAVGCVRNLKQIVDSLTEMYYIGTAITTCEALTE 1541

Query: 1514 FDYLPPVDSRSSSGFVGLRNGGATCYMNAVFQQLYMQPGLPESLLS-------VDDDTD- 1565
            ++YLPPV  R   GFVGL+N GATCYMN+V QQLYM P +   +L+       VDDD   
Sbjct: 1542 WEYLPPVGPRPPKGFVGLKNAGATCYMNSVIQQLYMIPSIRNGILAIEGTGSDVDDDMSG 1601

Query: 1566 ----------NPDDSVF--------------------------YQVQSLFGHLMESKLQY 1589
                      +P D VF                            +Q +FGHL  S+LQY
Sbjct: 1602 DEKQDNESNVDPRDDVFGYPQQFEDKPALSKTEDRKEYNIGVLRHLQVIFGHLAASRLQY 1661

Query: 1590 YVPENFWKIFKMWNKELYVREQQDAYEFFTSLIDQMDEYLKKMGRDQIFKNTFQGIYSDQ 1649
            YVP  FWK F++W + + +REQ DA EFF SL+D +DE LK +G   +      G ++DQ
Sbjct: 1662 YVPRGFWKQFRLWGEPVNLREQHDALEFFNSLVDSLDEALKALGHPAMLSKVLGGSFADQ 1721

Query: 1650 KICKDCPHRYEREEAFMALNLGVTSCQSLEISLDQFVRGEVLEGSNAYYCEKCKEKRITV 1709
            KIC+ CPHRYE EE+F  LN+ + + Q+L  SL+Q+V+G++LEG+NAY+CEKC +K  TV
Sbjct: 1722 KICQGCPHRYECEESFTTLNVDIRNHQNLLDSLEQYVKGDLLEGANAYHCEKCNKKVDTV 1781

Query: 1710 KRTCIKSLPSVLVIHLMRFGFDWESGRSIKYDEQIRFPWMLNMEPYTVSGMARQDSSSEV 1769
            KR  IK LP VL I L RF +DWE   +IK+++   FP  L+MEPYTV+G+A+ +  + V
Sbjct: 1782 KRLLIKKLPPVLAIQLKRFDYDWERECAIKFNDYFEFPRELDMEPYTVAGVAKLEGDN-V 1840

Query: 1770 GENGRSVDQGGGGSPRKKVALTENYELVGVIVHSGQAHAGHYYSFIKDRRGCG--KGKWY 1827
                + + Q        + A +  Y LVGV+VHSGQA  GHYYS+I  R G    + +WY
Sbjct: 1841 NPESQLIQQ--SEQSESETAGSTKYRLVGVLVHSGQASGGHYYSYIIQRNGGDGERNRWY 1898

Query: 1828 KFNDTVIEEFDL-NDETLEYECFGGEYRPKVYDQTNPYTDVRR--RYWNAYMLFYQRVS- 1883
            KF+D  + E  + +DE ++ +CFGGEY  +V+D        RR  R+WNAY+LFY+R+  
Sbjct: 1899 KFDDGDVTECKMDDDEEMKNQCFGGEYMGEVFDHMMKRMSYRRQKRWWNAYILFYERMDT 1958

Query: 1884 -DQNSPVLPKKSRVSVVRQEAEDLSLSAPSSPEISPQSSPRPHRPNNDRLSILTKLVKKG 1942
             DQ+  ++   S +++                      + RPH+       I+       
Sbjct: 1959 IDQDDELIRYISELAI----------------------TTRPHQ-------II------- 1982

Query: 1943 EKKGLFVEKMPARIYQMVRDENLKFMKNRDVYSSDYFSFVLSLASLNATKLKH------- 1995
                     MP+ I + VR +N++FM NR  YS +YF F+  L + N   L         
Sbjct: 1983 ---------MPSAIERSVRKQNVQFMHNRMQYSMEYFQFMKKLLTCNGVYLNPPPGQDHL 2033

Query: 1996 -PYYPCMAKVSLQLAIQFLFQTYLRTKKKLRVDTEEWIATIEALLSKSFDACQWLVEYFI 2054
             P    +  +S+QLA +FLF T   TKK +R    +W   +  LL  S +   W     +
Sbjct: 2034 LPEAEEITMISIQLAARFLFTTGFHTKKVVRGSASDWYDALCILLRHSKNVRFWFAHNVL 2093

Query: 2055 SSEGRELIKIFLLECNVREVRVAVATILEKTLDSAL----------------FYQDKLKS 2098
             +      + +LLEC   EVR A A ++      +L                   D L  
Sbjct: 2094 FNVSNRFSE-YLLECPSAEVRGAFAKLIVFIAHFSLQDGPCPSPFASPGPSSQAYDNLSL 2152

Query: 2099 LHQLLEVLLALLDKDVPENCKNCAQYFFLFNTFVQKQGIRAGDLLLRHS--ALRHMISFL 2156
               LL  +L LL ++V E+ ++  QYF LF  +    G+     LL+ S  A   ++S  
Sbjct: 2153 SDHLLRAVLNLLRREVSEHGRHLQQYFNLFVMYA-NLGVAEKTQLLKLSVPATFMLVSLD 2211

Query: 2157 LGASRQNNQIRRWSSAQAREFGNLHNTVALLVLHSDVSSQRNVAPGIFKQRPPI-----S 2211
             G              Q  E G L++ V+ L+   +VSS+   +       PP+      
Sbjct: 2212 EGPGPP-------IKYQYAELGKLYSVVSQLIRCCNVSSRMQSS---INGNPPLPNPFGD 2261

Query: 2212 IAPSSPLLPLHEEVEALLFMSEGKPYLLEVMFALRELTGSLLALIEMVVYCCFCNEHFSF 2271
               S P++P+ + V  +LF+     Y+ +++    E   +    ++++ +CC+ N  FS 
Sbjct: 2262 PNLSQPIMPIQQNVADILFVRTS--YVKKII----EDCSNSEETVKLLRFCCWENPQFSS 2315

Query: 2272 TMLHFIKNQLETAPPHELKNTFQLLHEILVIEDPIQVERV----KFVFETENGLLALMHH 2327
            T+L  +  Q+  +  +EL+    LL +IL+IED  Q  R+    K + +  +GL   +  
Sbjct: 2316 TVLSELLWQVAYSYTYELRPYLDLLLQILLIEDSWQTHRIHNALKGIPDDRDGLFDTIQR 2375

Query: 2328 SNHVDSSRCYQCVKFLVTLAQKCPAAKEYFKEN---SHHWSWAVQWLQKKMSE------- 2377
            S +    R YQC+K +V L   CP A +  + N      W+WAV+WL  ++         
Sbjct: 2376 SKNHYQKRAYQCIKCMVALFSNCPVAYQILQGNGDLKRKWTWAVEWLGDELERRPYTGNP 2435

Query: 2378 ----HYWTPQSNVSNETSTGKTFQRTISAQDTLAYATALLNEKEQSGSS-NGSESSPANE 2432
                + W+P    SNETS G   +R+ SA+ TLA A  L  E+ +  +S    E   + E
Sbjct: 2436 QYTYNNWSPPVQ-SNETSNGYFLERSHSARMTLAKACELCPEEVKKATSVQQIEMEESKE 2494

Query: 2433 NGDRHLQQGSESP 2445
              D+      ESP
Sbjct: 2495 PDDQDAPDEHESP 2507


>gi|145309311 ubiquitin specific protease 9, X-linked isoform 4 [Homo
            sapiens]
          Length = 2554

 Score =  958 bits (2477), Expect = 0.0
 Identities = 767/2581 (29%), Positives = 1223/2581 (47%), Gaps = 392/2581 (15%)

Query: 52   GLSESDENCRRFMDRCMPEAFKKLLTSSAVHKWGTEIHEGIYNMLMLLIELVAERIKQDP 111
            GL    E C+RF    +  +F K+LT  AV  W  EIH  I N    L+EL   ++ QD 
Sbjct: 108  GLDVKSEACQRFFRDGLTISFTKILTDEAVSGWKFEIHRCIINNTHRLVELCVAKLSQDW 167

Query: 112  IPTGLLGVLTMAFNPDNEYHFKNRMKVSQRNWAEV-FGEGNMFAVSPVSTFQKEPHGWVV 170
             P  LL +L MA NP  ++H  N  +  +   + V   E  +FA SP     + P GW+V
Sbjct: 168  FP--LLELLAMALNPHCKFHIYNGTRPCESVSSSVQLPEDELFARSP---DPRSPKGWLV 222

Query: 171  DLVNKFGELGGFAAIQAK-LHSEDIELGAVSALIQPLGVCAEYLNSSVVQPMLDPVILTT 229
            DL+NKFG L GF  +  + ++   + +  ++ALI+P G C E+L    V+    P+I   
Sbjct: 223  DLLNKFGTLNGFQILHDRFINGSALNVQIIAALIKPFGQCYEFLTLHTVKKYFLPIIEMV 282

Query: 230  IQDVRSVEEKDLK-----DKRLVSIPELLSAVKLLCMRF--QPDLVTIVDDLRLDILLRM 282
             Q + ++ +++LK     + +  ++  ++ ++K L  R   Q + V  ++  RL ++LR+
Sbjct: 283  PQFLENLTDEELKKEAKNEAKNDALSMIIKSLKNLASRVPGQEETVKNLEIFRLKMILRL 342

Query: 283  LKSPHFSAKMNSLKEVTKLIEDSTL------SKSVKNAIDTDRLLDWLVENSVLSIALEG 336
            L+   F+ KMN+L EV K+I   +       +   +  +  +R+ +W+ +N++LSI L  
Sbjct: 343  LQISSFNGKMNALNEVNKVISSVSYYTHRHGNPEEEEWLTAERMAEWIQQNNILSIVLRD 402

Query: 337  NIDQAQYCDRIKGIIELL--GSKLSLDELTKIWKIQSGQSSTVIENIHTIIAAAAVKFNS 394
            ++ Q QY ++++ I+  +     L+L +L  IW  Q+G+   +++N+H ++A  A  F+ 
Sbjct: 403  SLHQPQYVEKLEKILRFVIKEKALTLQDLDNIWAAQAGKHEAIVKNVHDLLAKLAWDFSP 462

Query: 395  DQLNHLF--------------------------------VLIQKVLDVLWELAHLPTLPS 422
            +QL+HLF                                V+  KVL++LW LAH   +P 
Sbjct: 463  EQLDHLFDCFKASWTNASKKQREKLLELIRRLAEDDKDGVMAHKVLNLLWNLAHSDDVPV 522

Query: 423  SLIQQALEEHLTILSDAYAV-KEAIKRSYIIKCIEDIKRSSQLNNPQFVWVVPALRQLHE 481
             ++  AL  H+ IL  + +  ++  K  +I + IE+++ + +       WV+PAL+Q+ E
Sbjct: 523  DIMDLALSAHIKILDYSCSQDRDTQKIQWIDRFIEELRTNDK-------WVIPALKQIRE 575

Query: 482  ITRSF------IKQTYQKQD----KSIIQDLKKNFEIVKLVTGSLIA-CHRLAAAVAGPG 530
            I   F      + QT +         +I  L+ N  +V LV  +L      +        
Sbjct: 576  ICSLFGEAPQNLSQTQRSPHVFYRHDLINQLQHNHALVTLVAENLATYMESMRLYARDHE 635

Query: 531  GLSGSTL-VDGRYTYREYLEAHLKFLAFFLQEATLYLGWNRAKEIWECLVTGQDVCELDR 589
                 T+ +  RY++ + ++  L FL F L++  L+L   +AK+IW+CL     V   DR
Sbjct: 636  DYDPQTVRLGSRYSHVQEVQERLNFLRFLLKDGQLWLCAPQAKQIWKCLAENA-VYLCDR 694

Query: 590  EMCFEWFTK---GQHDLESDVQQQLFKEKILKLESYEITMNGFNLFKTFFENVNLCDHRL 646
            E CF+W++K    + DL+ D+ +  F+  +L+L+   +T NG   F+ FF+ VN  + +L
Sbjct: 695  EACFKWYSKLMGDEPDLDPDINKDFFESNVLQLDPSLLTENGMKCFERFFKAVNCREGKL 754

Query: 647  KRQGAQLYVEKLELIGMDFIWKIAMESPDEEIANEAIQLIINYSYINLNPRLKKDSVSLH 706
              +     ++ LELIG+D++W++ ++S D +IA+ AI L +   Y NL PRL+ + V +H
Sbjct: 755  VAKRRAYMMDDLELIGLDYLWRVVIQSND-DIASRAIDL-LKEIYTNLGPRLQVNQVVIH 812

Query: 707  KKFIADCYTRLEAASSALGGPTLTHAVTRATKMLTATAMPTVATSVQSPYRSTKLVIIER 766
            + FI  C+ RL+A+   L        V    K        +V  + Q   R      + R
Sbjct: 813  EDFIQSCFDRLKASYDTL-------CVLDGDK-------DSVNCARQEAVR------MVR 852

Query: 767  LLLLAERYVITIEDFYSVPRTILPHGASFHGHLLTLNVTYES---TKDTFTVEAHSNETI 823
            +L +   Y+   +  Y   RTILP   +F G  L+  V + +     D   V +H+N+TI
Sbjct: 853  VLTVLREYINECDSDYHEERTILPMSRAFRGKHLSFVVRFPNQGRQVDDLEVWSHTNDTI 912

Query: 824  GSVRWKIAKQLCSPV--DNIQIFTNDSLLTVNKDQKLLHQLGFSDEQILTVKTSGSGTPS 881
            GSVR  I  ++ + V    I++F    L+    D+KL+ QL   D+ ++T K +   +  
Sbjct: 913  GSVRRCILNRIKANVAHTKIELFVGGELIDPADDRKLIGQLNLKDKSLITAKLTQISSNM 972

Query: 882  GSSADSSTSSSSSSSGVFSSSYA----MEQEKSLPGVVMALVCNVFDMLYQLA----NLE 933
             SS DSS+ SS+ S G   + Y+     E E  LPGV+M+L       L+Q+A    +L 
Sbjct: 973  PSSPDSSSDSSTGSPGNHGNHYSDGPNPEVESCLPGVIMSLHPRYISFLWQVADLGSSLN 1032

Query: 934  EPRITLRVRKLLLLIPTDPAIQEALDQLDSLGRKKTLLSESSSQSSKSPSLSSKQQHQPS 993
             P +    R L+ L+P D    E L       R   L      +SS SPS          
Sbjct: 1033 MPPLRDGARVLMKLMPPDSTTIEKL-------RAICLDHAKLGESSLSPS---------- 1075

Query: 994  ASSILESLFRSFAPGMSTFRVLYNLEVLSSKLMPT----ADDDMARSCAKSFCENFLKAG 1049
                L+SLF  F P  S  +VLY  EV+ + LMP     ADD      +  F  +FLK+G
Sbjct: 1076 ----LDSLF--FGPSAS--QVLYLTEVVYALLMPAGAPLADD------SSDFQFHFLKSG 1121

Query: 1050 GLSLVVNVMQRDSIPSEVDYETRQGVYSICLQLARFLL--VGQTMPTLLDEDLTKDGIEA 1107
            GL LV++++ R++     D ETR+G Y   L++A+ LL  +G      + E   + G+E 
Sbjct: 1122 GLPLVLSMLTRNNFLPNADMETRRGAYLNALKIAKLLLTAIGYGHVRAVAE-ACQPGVEG 1180

Query: 1108 LSSRPFRNVSRQTSRQMSLCGTPEKSSYRQLSVSDRSSIRVEEIIPAARVAIQTMEVSDF 1167
            ++  P   +++ T  Q  +  +  +S     + S    +R   +  A +++ +       
Sbjct: 1181 VN--PMTQINQVTHDQAVVLQSALQSI---PNPSSECMLRNVSVRLAQQISDEASRYMPD 1235

Query: 1168 TSTVACFMRLSWAAAAGRLDLVGSSQPIKESNSLCPAGIRNRLSSSGSNCSSGSEGEPVA 1227
               +    ++ WA+  G L LV S                  ++      ++G+E +   
Sbjct: 1236 ICVIRAIQKIIWASGCGSLQLVFSP--------------NEEITKIYEKTNAGNEPD--- 1278

Query: 1228 LHAGICVRQQSVSTKDSLIAGEALSLLVTCLQLRSQQLASFYNLPCVADFIIDILLGSPS 1287
                          +D  +  EAL ++  C  L    L +         FIID+LL   S
Sbjct: 1279 -------------LEDEQVCCEALEVMTLCFALIPTALDALSKEKAWQTFIIDLLLHCHS 1325

Query: 1288 AEIRRVACDQLYTLSQTDTSAHPDVQKPNQFLLGVILTAQLPLWSPTSIMRGVNQRLLSQ 1347
              +R+VA +Q + +       H    +P  F + ++ T          ++    +     
Sbjct: 1326 KTVRQVAQEQFFLMCTRCCMGH----RPLLFFITLLFT----------VLGSTARERAKH 1371

Query: 1348 CMEYFDLRCQLLDDLTTSEMEQLRISPATMLEDEITWLDNFEPNRTAECETSEADNILLA 1407
              +YF L   LL+    S +     +   +L +EI WL     +     ET   +  +L 
Sbjct: 1372 SGDYFTLLRHLLNYAYNSNINV--PNAEVLLNNEIDWLKRIRDDVKRTGETG-IEETILE 1428

Query: 1408 GHLRLIKTLLSLCGAEK------EMLGSSLIKPLLDDFLFRASRIIL----NSHSPAGSA 1457
            GHL + K LL+   +EK      E  G++LIK L+DDF+F AS + L    N   PA  A
Sbjct: 1429 GHLGVTKELLAFQTSEKKFHIGCEKGGANLIKELIDDFIFPASNVYLQYMRNGELPAEQA 1488

Query: 1458 AISQQDFHPKCSTANSRLAAYEVLVMLADSSPSNLQIIIKELLSMHHQPDPALT----KE 1513
                    P C +  +  A +E+LV LA     NL+ I+  L  M++      T     E
Sbjct: 1489 I-------PVCGSPPTINAGFELLVALAVGCVRNLKQIVDSLTEMYYIGTAITTCEALTE 1541

Query: 1514 FDYLPPVDSRSSSGFVGLRNGGATCYMNAVFQQLYMQPGLPESLLS-------VDDDTD- 1565
            ++YLPPV  R   GFVGL+N GATCYMN+V QQLYM P +   +L+       VDDD   
Sbjct: 1542 WEYLPPVGPRPPKGFVGLKNAGATCYMNSVIQQLYMIPSIRNGILAIEGTGSDVDDDMSG 1601

Query: 1566 ----------NPDDSVF--------------------------YQVQSLFGHLMESKLQY 1589
                      +P D VF                            +Q +FGHL  S+LQY
Sbjct: 1602 DEKQDNESNVDPRDDVFGYPQQFEDKPALSKTEDRKEYNIGVLRHLQVIFGHLAASRLQY 1661

Query: 1590 YVPENFWKIFKMWNKELYVREQQDAYEFFTSLIDQMDEYLKKMGRDQIFKNTFQGIYSDQ 1649
            YVP  FWK F++W + + +REQ DA EFF SL+D +DE LK +G   +      G ++DQ
Sbjct: 1662 YVPRGFWKQFRLWGEPVNLREQHDALEFFNSLVDSLDEALKALGHPAMLSKVLGGSFADQ 1721

Query: 1650 KICKDCPHRYEREEAFMALNLGVTSCQSLEISLDQFVRGEVLEGSNAYYCEKCKEKRITV 1709
            KIC+ CPHRYE EE+F  LN+ + + Q+L  SL+Q+V+G++LEG+NAY+CEKC +K  TV
Sbjct: 1722 KICQGCPHRYECEESFTTLNVDIRNHQNLLDSLEQYVKGDLLEGANAYHCEKCNKKVDTV 1781

Query: 1710 KRTCIKSLPSVLVIHLMRFGFDWESGRSIKYDEQIRFPWMLNMEPYTVSGMARQDSSSEV 1769
            KR  IK LP VL I L RF +DWE   +IK+++   FP  L+MEPYTV+G+A+ +  + V
Sbjct: 1782 KRLLIKKLPPVLAIQLKRFDYDWERECAIKFNDYFEFPRELDMEPYTVAGVAKLEGDN-V 1840

Query: 1770 GENGRSVDQGGGGSPRKKVALTENYELVGVIVHSGQAHAGHYYSFIKDRRGCG--KGKWY 1827
                + + Q        + A +  Y LVGV+VHSGQA  GHYYS+I  R G    + +WY
Sbjct: 1841 NPESQLIQQ--SEQSESETAGSTKYRLVGVLVHSGQASGGHYYSYIIQRNGGDGERNRWY 1898

Query: 1828 KFNDTVIEEFDL-NDETLEYECFGGEYRPKVYDQTNPYTDVRR--RYWNAYMLFYQRVS- 1883
            KF+D  + E  + +DE ++ +CFGGEY  +V+D        RR  R+WNAY+LFY+R+  
Sbjct: 1899 KFDDGDVTECKMDDDEEMKNQCFGGEYMGEVFDHMMKRMSYRRQKRWWNAYILFYERMDT 1958

Query: 1884 -DQNSPVLPKKSRVSVVRQEAEDLSLSAPSSPEISPQSSPRPHRPNNDRLSILTKLVKKG 1942
             DQ+  ++   S +++                      + RPH+       I+       
Sbjct: 1959 IDQDDELIRYISELAI----------------------TTRPHQ-------II------- 1982

Query: 1943 EKKGLFVEKMPARIYQMVRDENLKFMKNRDVYSSDYFSFVLSLASLNATKLKH------- 1995
                     MP+ I + VR +N++FM NR  YS +YF F+  L + N   L         
Sbjct: 1983 ---------MPSAIERSVRKQNVQFMHNRMQYSMEYFQFMKKLLTCNGVYLNPPPGQDHL 2033

Query: 1996 -PYYPCMAKVSLQLAIQFLFQTYLRTKKKLRVDTEEWIATIEALLSKSFDACQWLVEYFI 2054
             P    +  +S+QLA +FLF T   TKK +R    +W   +  LL  S +   W     +
Sbjct: 2034 LPEAEEITMISIQLAARFLFTTGFHTKKVVRGSASDWYDALCILLRHSKNVRFWFAHNVL 2093

Query: 2055 SSEGRELIKIFLLECNVREVRVAVATILEKTLDSAL----------------FYQDKLKS 2098
             +      + +LLEC   EVR A A ++      +L                   D L  
Sbjct: 2094 FNVSNRFSE-YLLECPSAEVRGAFAKLIVFIAHFSLQDGPCPSPFASPGPSSQAYDNLSL 2152

Query: 2099 LHQLLEVLLALLDKDVPENCKNCAQYFFLFNTFVQKQGIRAGDLLLRHS--ALRHMISFL 2156
               LL  +L LL ++V E+ ++  QYF LF  +    G+     LL+ S  A   ++S  
Sbjct: 2153 SDHLLRAVLNLLRREVSEHGRHLQQYFNLFVMYA-NLGVAEKTQLLKLSVPATFMLVSLD 2211

Query: 2157 LGASRQNNQIRRWSSAQAREFGNLHNTVALLVLHSDVSSQRNVAPGIFKQRPPI-----S 2211
             G              Q  E G L++ V+ L+   +VSS+   +       PP+      
Sbjct: 2212 EGPGPP-------IKYQYAELGKLYSVVSQLIRCCNVSSRMQSS---INGNPPLPNPFGD 2261

Query: 2212 IAPSSPLLPLHEEVEALLFMSEGKPYLLEVMFALRELTGSLLALIEMVVYCCFCNEHFSF 2271
               S P++P+ + V  +LF+     Y+ +++    E   +    ++++ +CC+ N  FS 
Sbjct: 2262 PNLSQPIMPIQQNVADILFVRTS--YVKKII----EDCSNSEETVKLLRFCCWENPQFSS 2315

Query: 2272 TMLHFIKNQLETAPPHELKNTFQLLHEILVIEDPIQVERV----KFVFETENGLLALMHH 2327
            T+L  +  Q+  +  +EL+    LL +IL+IED  Q  R+    K + +  +GL   +  
Sbjct: 2316 TVLSELLWQVAYSYTYELRPYLDLLLQILLIEDSWQTHRIHNALKGIPDDRDGLFDTIQR 2375

Query: 2328 SNHVDSSRCYQCVKFLVTLAQKCPAAKEYFKEN---SHHWSWAVQWLQKKMSE------- 2377
            S +    R YQC+K +V L   CP A +  + N      W+WAV+WL  ++         
Sbjct: 2376 SKNHYQKRAYQCIKCMVALFSNCPVAYQILQGNGDLKRKWTWAVEWLGDELERRPYTGNP 2435

Query: 2378 ----HYWTPQSNVSNETSTGKTFQRTISAQDTLAYATALLNEKEQSGSSNGSE-SSPANE 2432
                + W+P    SNETS G   +R+ SA+ TLA A  L  E+E        E  SP  E
Sbjct: 2436 QYTYNNWSPPVQ-SNETSNGYFLERSHSARMTLAKACELCPEEEPDDQDAPDEHESPPPE 2494

Query: 2433 N 2433
            +
Sbjct: 2495 D 2495


>gi|74319833 ubiquitin specific protease 9, Y-linked [Homo sapiens]
          Length = 2555

 Score =  942 bits (2434), Expect = 0.0
 Identities = 758/2574 (29%), Positives = 1202/2574 (46%), Gaps = 385/2574 (14%)

Query: 52   GLSESDENCRRFMDRCMPEAFKKLLTSSAVHKWGTEIHEGIYNMLMLLIELVAERIKQDP 111
            GL    E C+RF    +  +F K+L   AV  W  EIH  I N    L+EL   ++ QD 
Sbjct: 109  GLDVKSEACQRFFRDGLTISFTKILMDEAVSGWKFEIHRCIINNTHRLVELCVAKLSQDW 168

Query: 112  IPTGLLGVLTMAFNPDNEYHFKNRMKVSQRNWAEV-FGEGNMFAVSPVSTFQKEPHGWVV 170
             P  LL +L MA NP  ++H  N  +  +   +     E  +FA S   +  + P GW+V
Sbjct: 169  FP--LLELLAMALNPHCKFHIYNGTRPCELISSNAQLPEDELFARS---SDPRSPKGWLV 223

Query: 171  DLVNKFGELGGFAAIQAKL-HSEDIELGAVSALIQPLGVCAEYLNSSVVQPMLDPVILTT 229
            DL+NKFG L GF  +  +  +   + +  ++ALI+P G C E+L+   ++    PVI   
Sbjct: 224  DLINKFGTLNGFQILHDRFFNGSALNIQIIAALIKPFGQCYEFLSQHTLKKYFIPVIEIV 283

Query: 230  IQDVRSVEEKDLK-----DKRLVSIPELLSAVKLLCMRF--QPDLVTIVDDLRLDILLRM 282
               + ++ +++LK     + +  ++  ++ ++K L  R   Q + +  ++  RL ++LR+
Sbjct: 284  PHLLENLTDEELKKEAKNEAKNDALSMIIKSLKNLASRISGQDETIKNLEIFRLKMILRL 343

Query: 283  LKSPHFSAKMNSLKEVTKLIEDSTL------SKSVKNAIDTDRLLDWLVENSVLSIALEG 336
            L+   F+ KMN+L E+ K+I   +       +   +  +  +R+ +W+ +N++LSI L+ 
Sbjct: 344  LQISSFNGKMNALNEINKVISSVSYYTHRHSNPEEEEWLTAERMAEWIQQNNILSIVLQD 403

Query: 337  NIDQAQYCDRIKGIIELLGSK--LSLDELTKIWKIQSGQSSTVIENIHTIIAAAAVKFNS 394
            ++ Q QY ++++ I+  +  +  L+L +L  IW  Q+G+   +++N+H ++A  A  F+ 
Sbjct: 404  SLHQPQYVEKLEKILRFVIKEKALTLQDLDNIWAAQAGKHEAIVKNVHDLLAKLAWDFSP 463

Query: 395  DQLNHLF--------------------------------VLIQKVLDVLWELAHLPTLPS 422
             QL+HLF                                V+  KVL++LW LA    +P 
Sbjct: 464  GQLDHLFDCFKASWTNASKKQREKLLELIRRLAEDDKDGVMAHKVLNLLWNLAQSDDVPV 523

Query: 423  SLIQQALEEHLTILSDAYAV-KEAIKRSYIIKCIEDIKRSSQLNNPQFVWVVPALRQLHE 481
             ++  AL  H+ IL  + +  ++A K  +I   IE+++ + +       WV+PAL+Q+ E
Sbjct: 524  DIMDLALSAHIKILDYSCSQDRDAQKIQWIDHFIEELRTNDK-------WVIPALKQIRE 576

Query: 482  ITRSF------IKQTYQKQD----KSIIQDLKKNFEIVKLVTGSLIACHRLAAAVAGPGG 531
            I   F      + QT +         +I  L++N  +V LV  +L          AG   
Sbjct: 577  ICSLFGEASQNLSQTQRSPHIFYRHDLINQLQQNHALVTLVAENLATYMNSIRLYAGDHE 636

Query: 532  LSGSTLV--DGRYTYREYLEAHLKFLAFFLQEATLYLGWNRAKEIWECLVTGQDVCELDR 589
                  V    RY++ + ++  L FL F L++  L+L   +AK+IW+CL     V   DR
Sbjct: 637  DYDPQTVRLGSRYSHVQEVQERLNFLRFLLKDGQLWLCAPQAKQIWKCLAENA-VYLCDR 695

Query: 590  EMCFEWFTK---GQHDLESDVQQQLFKEKILKLESYEITMNGFNLFKTFFENVNLCDHRL 646
            E CF+W++K    + DL+ D+ +  F+  +L+L+   +T NG   F+ FF+ VN  + +L
Sbjct: 696  EACFKWYSKLMGDEPDLDPDINKDFFESNVLQLDPSLLTENGMKCFERFFKAVNCRERKL 755

Query: 647  KRQGAQLYVEKLELIGMDFIWKIAMESPDEEIANEAIQLIINYSYINLNPRLKKDSVSLH 706
              +     ++ LELIG+D++W++ ++S DE IAN AI L+    Y NL PRLK + V +H
Sbjct: 756  IAKRRSYMMDDLELIGLDYLWRVVIQSSDE-IANRAIDLLKEI-YTNLGPRLKANQVVIH 813

Query: 707  KKFIADCYTRLEAASSALGGPTLTHAVTRATKMLTATAMPTVATSVQSPYRSTKLVIIER 766
            + FI  C+ RL+A+   L        V    K     A       V             R
Sbjct: 814  EDFIQSCFDRLKASYDTL-------CVFDGDKNSINCARQEAIRMV-------------R 853

Query: 767  LLLLAERYVITIEDFYSVPRTILPHGASFHGHLLTLNVTYESTK---DTFTVEAHSNETI 823
            +L + + Y+   +  Y   R ILP   +F G  L+L V + +     D   + +H+N+TI
Sbjct: 854  VLTVIKEYINECDSDYHKERMILPMSRAFRGKHLSLIVRFPNQGRQVDELDIWSHTNDTI 913

Query: 824  GSVRWKIAKQLCSPVDN--IQIFTNDSLLTVNKDQKLLHQLGFSDEQILTVKTSGSGTPS 881
            GSVR  I  ++ + V +  I++F    L+    D+KL+ QL   D+ ++T K +      
Sbjct: 914  GSVRRCIVNRIKANVAHKKIELFVGGELIDSEDDRKLIGQLNLKDKSLITAKLTQINFNM 973

Query: 882  GSSADSSTSSSSSSSGVFSSSYA----MEQEKSLPGVVMALVCNVFDMLYQLA----NLE 933
             SS DSS+ SS++S G   + Y     +E E  LPGV+M++       L+Q+A    NL 
Sbjct: 974  PSSPDSSSDSSTASPGNHRNHYNDGPNLEVESCLPGVIMSVHPRYISFLWQVADLGSNLN 1033

Query: 934  EPRITLRVRKLLLLIPTDPAIQEALDQLDSLGRKKTLLSESSSQSSKSPSLSSKQQHQPS 993
             P +    R L+ L+P D    E L                     ++  L   +  +  
Sbjct: 1034 MPPLRDGARVLMKLMPPDRTAVEKL---------------------RAVCLDHAKLGEGK 1072

Query: 994  ASSILESLFRSFAPGMSTFRVLYNLEVLSSKLMPTADDDMARSCAKSFCENFLKAGGLSL 1053
             S  L+SLF  F P  S  +VLY  EV+ + LMP          +  F  +FLK+GGL L
Sbjct: 1073 LSPPLDSLF--FGPSAS--QVLYLTEVVYALLMPAGVP--LTDGSSDFQVHFLKSGGLPL 1126

Query: 1054 VVNVMQRDSIPSEVDYETRQGVYSICLQLARFLLV----GQTMPTLLDEDLTKDGIEALS 1109
            V++++ R++     D ETR+G Y   L++A+ LL     G             DG + ++
Sbjct: 1127 VLSMLIRNNFLPNTDMETRRGAYLNALKIAKLLLTAIGYGHVRAVAEACQPVVDGTDPIT 1186

Query: 1110 SRPFRNVSRQTSRQMSLCGTPEKSSYRQLSVSDRSSIRVEEIIPAARVAIQTMEVSDFTS 1169
                    +    Q +L   P  SS           +R E I+ A  ++ +         
Sbjct: 1187 QINQVTHDQAVVLQSALQSIPNPSS--------ECVLRNESILLAQEISNEASRYMPDIC 1238

Query: 1170 TVACFMRLSWAAAAGRLDLVGSSQPIKESNSLCPAGIRNRLSSSGSNCSSGSEGEPVALH 1229
             +    ++ WA+A G L LV S  P +E   +       +++++GSN             
Sbjct: 1239 VIRAIQKIIWASACGALGLVFS--PNEEITKIY------QMTTNGSN------------- 1277

Query: 1230 AGICVRQQSVSTKDSLIAGEALSLLVTCLQLRSQQLASFYNLPCVADFIIDILLGSPSAE 1289
                     +  +D  +  EAL ++  C  L    L +         FIID+LL  PS  
Sbjct: 1278 --------KLEVEDEQVCCEALEVMTLCFALLPTALDALSKEKAWQTFIIDLLLHCPSKT 1329

Query: 1290 IRRVACDQLYTLSQTDTSAHPDVQKPNQFLLGVILTAQLPLWSPTSIMRGVNQRLLSQCM 1349
            +R++A +Q + +       H    +P  F + ++ T          I+    +       
Sbjct: 1330 VRQLAQEQFFLMCTRCCMGH----RPLLFFITLLFT----------ILGSTAREKGKYSG 1375

Query: 1350 EYFDLRCQLLDDLTTSEMEQLRISPATMLEDEITWLDNFEPNRTAECETSEADNILLAGH 1409
            +YF L   LL+      +         +L  EI WL     N     ET   + IL  GH
Sbjct: 1376 DYFTLLRHLLNYAYNGNINIPNAE--VLLVSEIDWLKRIRDNVKNTGETGVEEPIL-EGH 1432

Query: 1410 LRLIKTLLSLCGAEK------EMLGSSLIKPLLDDFLFRASRIILNSHSPAGSAAISQQD 1463
            L + K LL+   +EK      E  G++LIK L+DDF+F AS++ L       S  +  + 
Sbjct: 1433 LGVTKELLAFQTSEKKYHFGCEKGGANLIKELIDDFIFPASKVYLQY---LRSGELPAEQ 1489

Query: 1464 FHPKCSTANSRLAAYEVLVMLADSSPSNLQIIIKELLSMHHQPDPALT----KEFDYLPP 1519
              P CS+  +  A +E+LV LA     NL+ I+  L  M++      T     E++YLPP
Sbjct: 1490 AIPVCSSPVTINAGFELLVALAIGCVRNLKQIVDCLTEMYYMGTAITTCEALTEWEYLPP 1549

Query: 1520 VDSRSSSGFVGLRNGGATCYMNAVFQQLYMQPGLPESLLSVD------------------ 1561
            V  R   GFVGL+N GATCYMN+V QQLYM P +  S+L+++                  
Sbjct: 1550 VGPRPPKGFVGLKNAGATCYMNSVIQQLYMIPSIRNSILAIEGTGSDLHDDMFGDEKQDS 1609

Query: 1562 DDTDNPDDSVF--------------------------YQVQSLFGHLMESKLQYYVPENF 1595
            +   +P D VF                            +Q +FGHL  S+LQYYVP  F
Sbjct: 1610 ESNVDPRDDVFGYPHQFEDKPALSKTEDRKEYNIGVLRHLQVIFGHLAASQLQYYVPRGF 1669

Query: 1596 WKIFKMWNKELYVREQQDAYEFFTSLIDQMDEYLKKMGRDQIFKNTFQGIYSDQKICKDC 1655
            WK F++W + + +REQ DA EFF SL+D +DE LK +G   I      G ++DQKIC+ C
Sbjct: 1670 WKQFRLWGEPVNLREQHDALEFFNSLVDSLDEALKALGHPAILSKVLGGSFADQKICQGC 1729

Query: 1656 PHRYEREEAFMALNLGVTSCQSLEISLDQFVRGEVLEGSNAYYCEKCKEKRITVKRTCIK 1715
            PHRYE EE+F  LN+ + + Q+L  SL+Q+++G++LEG+NAY+CEKC +K  TVKR  IK
Sbjct: 1730 PHRYECEESFTTLNVDIRNHQNLLDSLEQYIKGDLLEGANAYHCEKCDKKVDTVKRLLIK 1789

Query: 1716 SLPSVLVIHLMRFGFDWESGRSIKYDEQIRFPWMLNMEPYTVSGMA---RQDSSSE---V 1769
             LP VL I L RF +DWE   +IK+++   FP  L+M PYTV+G+A   R + +SE   +
Sbjct: 1790 KLPRVLAIQLKRFDYDWERECAIKFNDYFEFPRELDMGPYTVAGVANLERDNVNSENELI 1849

Query: 1770 GENGRSVDQGGGGSPRKKVALTENYELVGVIVHSGQAHAGHYYSFIKDRRGCG--KGKWY 1827
             +  +S ++  GG+          Y LVGV+VHSGQA  GHYYS+I  R G       WY
Sbjct: 1850 EQKEQSDNETAGGT---------KYRLVGVLVHSGQASGGHYYSYIIQRNGKDDQTDHWY 1900

Query: 1828 KFNDTVIEEFDL-NDETLEYECFGGEYRPKVYDQTNPYTDVRR--RYWNAYMLFYQRVSD 1884
            KF+D  + E  + +DE ++ +CFGGEY  +V+D        RR  R+WNAY+LFY+    
Sbjct: 1901 KFDDGDVTECKMDDDEEMKNQCFGGEYMGEVFDHMMKRMSYRRQKRWWNAYILFYE---- 1956

Query: 1885 QNSPVLPKKSRVSVVRQEAEDLSLSAPSSPEISPQSSPRPHRPNNDRLSILTKLVKKGEK 1944
                      ++ ++ ++ E +         IS  +  RPH+                  
Sbjct: 1957 ----------QMDMIDEDDEMIRY-------ISELTIARPHQ------------------ 1981

Query: 1945 KGLFVEKMPARIYQMVRDENLKFMKNRDVYSSDYFSFVLSLASLNATKLKH--------P 1996
                +   PA I + VR +N+KFM NR  YS +YF FV  L + N   L          P
Sbjct: 1982 ----IIMSPA-IERSVRKQNVKFMHNRLQYSLEYFQFVKKLLTCNGVYLNPAPGQDYLLP 2036

Query: 1997 YYPCMAKVSLQLAIQFLFQTYLRTKKKLRVDTEEWIATIEALLSKSFDACQWLVEYFISS 2056
                +  +S+QLA +FLF T   TKK +R    +W   +  LL  S +   W     + +
Sbjct: 2037 EAEEITMISIQLAARFLFTTGFHTKKIVRGPASDWYDALCVLLRHSKNVRFWFTHNVLFN 2096

Query: 2057 EGRELIKIFLLECNVREVRVAVATILEKTLDSAL--------FYQ--------DKLKSLH 2100
                  + +LLEC   EVR A A ++      +L        F          D L    
Sbjct: 2097 VSNRFSE-YLLECPSAEVRGAFAKLIVFIAHFSLQDGSCPSPFASPGPSSQACDNLSLSD 2155

Query: 2101 QLLEVLLALLDKDVPENCKNCAQYFFLFNTFVQKQGIRAGDLL-LRHSALRHMISFLLGA 2159
             LL   L LL ++V E+  +  QYF LF  +          LL L   A   ++S   G 
Sbjct: 2156 HLLRATLNLLRREVSEHGHHLQQYFNLFVMYANLGVAEKTQLLKLNVPATFMLVSLDEGP 2215

Query: 2160 SRQNNQIRRWSSAQAREFGNLHNTVALLVLHSDVSSQRNVAPGIFKQRPPI-----SIAP 2214
                         Q  E G L++ V+ L+   +VSS    +       PP+      +  
Sbjct: 2216 GPP-------IKYQYAELGKLYSVVSQLIRCCNVSSTMQSS---INGNPPLPNPFGDLNL 2265

Query: 2215 SSPLLPLHEEVEALLFMSEGKPYLLEVMFALRELTGSLLALIEMVVYCCFCNEHFSFTML 2274
            S P++P+ + V  +LF+     Y+ +++    E   +    I+++ +C + N  FS T+L
Sbjct: 2266 SQPIMPIQQNVLDILFVRTS--YVKKII----EDCSNSEDTIKLLRFCSWENPQFSSTVL 2319

Query: 2275 HFIKNQLETAPPHELKNTFQLLHEILVIEDPIQVERV----KFVFETENGLLALMHHSNH 2330
              +  Q+  +  +EL+    LL +IL+IED  Q  R+    K + +  +GL   +  S +
Sbjct: 2320 SELLWQVAYSYTYELRPYLDLLFQILLIEDSWQTHRIHNALKGIPDDRDGLFDTIQRSKN 2379

Query: 2331 VDSSRCYQCVKFLVTLAQKCPAAKEYFKEN---SHHWSWAVQWLQKKM-----------S 2376
                R YQC+K +V L   CP A +  + N      W+WAV+WL  ++           S
Sbjct: 2380 HYQKRAYQCIKCMVALFSSCPVAYQILQGNGDLKRKWTWAVEWLGDELERRPYTGNPQYS 2439

Query: 2377 EHYWTPQSNVSNETSTGKTFQRTISAQDTLAYATALLNEKEQSGSSNGSESSPA 2430
             + W+P    SNET+ G   +R+ SA+ TLA A  L  E+E        E  P+
Sbjct: 2440 YNNWSPPVQ-SNETANGYFLERSHSARMTLAKACELCPEEEPDDQDAPDEHEPS 2492


>gi|110347427 ubiquitin specific protease 34 [Homo sapiens]
          Length = 3546

 Score =  248 bits (634), Expect = 4e-65
 Identities = 192/638 (30%), Positives = 289/638 (45%), Gaps = 43/638 (6%)

Query: 1257 CLQLRSQQLASFYNLPCVADFIIDILLGSPSAEIRRVACDQLYTLSQTDTSAHPDVQKPN 1316
            C  L    LA   +L    D++  + L  P   +R  +C  LY LS +       + +  
Sbjct: 1639 CCSLVKSSLADSDHLQ---DWLKKLTLLIPETAVRHESCSGLYKLSLSGLDGGDSINRSF 1695

Query: 1317 QFLLGVILTAQLP---LWSPTSIMRGVNQRLLSQ-CMEYFDLRCQLLDDLTTSEMEQLRI 1372
              L    L   LP      P  I     + +L   C EYF L C+L+D++   +  Q  +
Sbjct: 1696 LLLAASTLLKFLPDAQALKPIRIDDYEEEPILKPGCKEYFWLLCKLVDNIHIKDASQTTL 1755

Query: 1373 SPATMLEDEITWLDNFEPNRTAECETSEADNILLAGHLRLIKTLLSLCGAEKEMLGSSLI 1432
                 L   +   D        + +    ++  L G LRL  +++      K        
Sbjct: 1756 LDLDALARHLA--DCIRSREILDHQDGNVEDDGLTGLLRLATSVVKHKPPFKFSREGQ-- 1811

Query: 1433 KPLLDDFLFRASRIILNSHSPAGSAAISQQDFHPKCSTANSRLAAYEVLVMLADSSPSNL 1492
                 +FL    R I N      S    QQ   PKC + +SR AAY++LV +   S  N 
Sbjct: 1812 -----EFL----RDIFNLLFLLPSLKDRQQ---PKCKSHSSRAAAYDLLVEMVKGSVENY 1859

Query: 1493 QIIIKELLSMHHQPDPALTKEFDYLPPVDSRSSSGFVGLRNGGATCYMNAVFQQLYMQPG 1552
            ++I   +++ H Q       ++DY P  D R+   FVGL N GATCY+ +  QQLYM P 
Sbjct: 1860 RLIHNWVMAQHMQSHAPY--KWDYWPHEDVRAECRFVGLTNLGATCYLASTIQQLYMIPE 1917

Query: 1553 LPESLLSVDDDTDNPDDSVFYQVQSLFGHLMESKLQYYVPENFWKIFKMWNKELYVREQQ 1612
              +++ +     D    +   ++Q +F +LMES+ + Y P  F K + M  + L   EQ+
Sbjct: 1918 ARQAVFTAKYSEDMKHKTTLLELQKMFTYLMESECKAYNPRPFCKTYTMDKQPLNTGEQK 1977

Query: 1613 DAYEFFTSLIDQMDEYLKKMGRDQIFKNTFQGIYSDQKICKDCPHRYEREEAFMALNLGV 1672
            D  EFFT LI +++E   ++      K+ F G+ ++  +  DC H  +  E F  +   V
Sbjct: 1978 DMTEFFTDLITKIEEMSPEL--KNTVKSLFGGVITNNVVSLDCEHVSQTAEEFYTVRCQV 2035

Query: 1673 TSCQSLEISLDQFVRGEVLEGSNAYYCEKCKEKRITVKRTCIKSLPSVLVIHLMRFGFDW 1732
               +++  SLD+    + LEG N Y C  C +K    KR C K LP +L  + MR+ F+ 
Sbjct: 2036 ADMKNIYESLDEVTIKDTLEGDNMYTCSHCGKKVRAEKRACFKKLPRILSFNTMRYTFNM 2095

Query: 1733 ESGRSIKYDEQIRFPWMLNMEPYTVSGMARQDSSSEVGENGRSVDQGGGGSPRKKVALTE 1792
             +    K +    FP  L+M PYT   +      SE  E  + V      S   K + + 
Sbjct: 2096 VTMMKEKVNTHFSFPLRLDMTPYTEDFLM---GKSERKEGFKEV------SDHSKDSESY 2146

Query: 1793 NYELVGVIVHSGQAHAGHYYSFIKD---RRGCGKGKWYKFNDTVIEEFDLNDETLEYECF 1849
             Y+L+GV VH+G A  GHYYSFI+D          KWY FND  ++ FD     L  ECF
Sbjct: 2147 EYDLIGVTVHTGTADGGHYYSFIRDIVNPHAYKNNKWYLFNDAEVKPFD--SAQLASECF 2204

Query: 1850 GGEYRPKVYDQ-TNPYTDVR-RRYWNAYMLFYQRVSDQ 1885
            GGE   K YD  T+ + D    +  +AYMLFY+R+  +
Sbjct: 2205 GGEMTTKTYDSVTDKFMDFSFEKTHSAYMLFYKRMEPE 2242



 Score = 80.5 bits (197), Expect = 2e-14
 Identities = 161/753 (21%), Positives = 284/753 (37%), Gaps = 179/753 (23%)

Query: 391  KFNSDQLNHLFV--LIQKVLDVLWELAH---LPTLPSSLIQQALEEHLTILSDAYAVKEA 445
            +FNS+ +  + +  + +K   +LW++        L   LI +A  E L      +     
Sbjct: 841  QFNSNAVTDINLDNVCKKGNTLLWDIVQDEDAVNLSEGLINEA--EKLLCSLVCWFTDRQ 898

Query: 446  IKRSYIIKCIEDIKRSSQLNNPQFVWVVPALRQLHEITRSFIKQTYQKQDKSIIQDLKKN 505
            I+  +I  C+E++  +          VV +LR L ++  +F +         I    +K 
Sbjct: 899  IRMRFIEGCLENLGNNRS--------VVISLRLLPKLFGTFQQFGSSYDTHWITMWAEKE 950

Query: 506  FEIVKLVTGSLIACHRLAAAVAGPGGLSGSTLVDGR-----YTYREYLEAHLKFLAFFLQ 560
              ++KL   +L+   +              T+ +GR     Y++   ++  L+FL     
Sbjct: 951  LNMMKLFFDNLVYYIQ--------------TVREGRQKHALYSHSAEVQVRLQFLTCVFS 996

Query: 561  EAT----LYLGWNRAKEIWECLVTGQDVCELDREMCFEWF-----TKGQHDLESDVQQQL 611
                     L   +   +W CLV   + C  D      WF     +K QH +  +  + L
Sbjct: 997  TLGSPDHFRLSLEQVDILWHCLVEDSE-CYDD---ALHWFLNQVRSKDQHAMGMETYKHL 1052

Query: 612  FKEKILKLESYEITMNGFNLFKTFFENVNLCDHRLKRQGAQLYVEKLELIGMDFIWKIAM 671
            F EK+ +L+   I+M G NLF+      +LC+       A       EL GMD  W IA+
Sbjct: 1053 FLEKMPQLKPETISMTGLNLFQ------HLCNLARLATSAYDGCSNSELCGMDQFWGIAL 1106

Query: 672  ESPDEEIANEAIQLIINYSYINLNPRLKKDSVSLHKKFIADCYTRLEAASSALGGPTLTH 731
             +   +++  AIQ I +Y YIN    L+K+     ++FI+ C   L  ASS+L       
Sbjct: 1107 RAQSGDVSRAAIQYINSY-YINGKTGLEKE-----QEFISKCMESLMIASSSL------- 1153

Query: 732  AVTRATKMLTATAMPTVATSVQSPYRSTKLVIIERLLLLAERYVITIEDFYSVP-RTILP 790
                                       + L++IER LL+ + ++      ++   R    
Sbjct: 1154 ----------------------EQESHSSLMVIERGLLMLKTHLEAFRRRFAYHLRQWQI 1191

Query: 791  HGASFHGHL--------LTLNVTYE--STKDTFTVEAHSNETIGSVR-----W--KIAKQ 833
             G     HL        L L V  +     D  T+E + ++ +  +R     W   + K+
Sbjct: 1192 EGTGISSHLKALSDKQSLPLRVVCQPAGLPDKMTIEMYPSDQVADLRAEVTHWYENLQKE 1251

Query: 834  LCSPVDNIQIF--------------------TNDSLLTVNKDQKLLHQLGFSDEQILTVK 873
              +    +Q F                    ++   LT + D+K LH+LGF D Q++ V 
Sbjct: 1252 QINQQAQLQEFGQSNRKGEFPGGLMGPVRMISSGHELTTDYDEKALHELGFKDMQMVFVS 1311

Query: 874  TSGSGTPSGSSADSSTSSSSSSSGVFSSSYAMEQEKSLPGVVMAL---VCNVFDMLYQLA 930
                G P                 + +S     Q+ ++P +++     +  +FD+L  LA
Sbjct: 1312 L---GAPRRERKGEGVQ-------LPASCLPPPQKDNIPMLLLLQEPHLTTLFDLLEMLA 1361

Query: 931  NLEEP----------------------RITLRVRKLLLLIPTDPAIQEALDQLDSLGRKK 968
            + + P                       ++ RV +LL+L+PT P +  A   +       
Sbjct: 1362 SFKPPSGKVAVDDSESLRCEELHLHAENLSRRVWELLMLLPTCPNMLMAFQNISD----- 1416

Query: 969  TLLSESSSQSSKSPSLSSKQQHQ-PSASSILESLFRSFAPGMSTFRVLYNLEVLSSKLMP 1027
                +S+   +    L  K  H+   A  I+E+L      G    R+        S L P
Sbjct: 1417 ---EQSNDGFNWKELLKIKSAHKLLYALEIIEAL------GKPNRRIRRESTGSYSDLYP 1467

Query: 1028 TADD---DMARSCAKSFCENFLKAGGLSLVVNV 1057
             +DD   D   +   S+   F+ AGGL  ++ +
Sbjct: 1468 DSDDSSEDQVENSKNSWSCKFVAAGGLQQLLEI 1500


>gi|71774197 ubiquitin specific protease 47 [Homo sapiens]
          Length = 1287

 Score =  146 bits (369), Expect = 2e-34
 Identities = 112/395 (28%), Positives = 177/395 (44%), Gaps = 49/395 (12%)

Query: 1522 SRSSSGFVGLRNGGATCYMNAVFQQLYMQPGLPESLLS--VDDDTDNPDDSVFYQVQSLF 1579
            ++S +G+VGL N   TCY+N++ Q L+M P    +L     ++  ++P  S+ YQ+Q LF
Sbjct: 93   NKSETGYVGLVNQAMTCYLNSLLQTLFMTPEFRNALYKWEFEESEEDPVTSIPYQLQRLF 152

Query: 1580 GHLMESKLQYYVPENFWKIFKMWNKELYVREQQDAYEFFTSLIDQMDEYLKKMGRDQIFK 1639
              L  SK +     +  + F   + E +  +Q D  E    + D +++  K+  +  +  
Sbjct: 153  VLLQTSKKRAIETTDVTRSFGWDSSEAW--QQHDVQELCRVMFDALEQKWKQTEQADLIN 210

Query: 1640 NTFQGIYSDQKICKDCPHRYEREEAFMALNLGVT------SCQSLEISLDQFVRGEVLEG 1693
              +QG   D   C +C +   R + ++ + L +       +  S+E +L  F++ E+L+G
Sbjct: 211  ELYQGKLKDYVRCLECGYEGWRIDTYLDIPLVIRPYGSSQAFASVEEALHAFIQPEILDG 270

Query: 1694 SNAYYCEKCKEKRITVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKYDEQIRFPWMLNM- 1752
             N Y+CE+CK+K    K       P +L + L RF FD+ +   IK ++++ FP  L+M 
Sbjct: 271  PNQYFCERCKKKCDARKGLRFLHFPYLLTLQLKRFDFDYTTMHRIKLNDRMTFPEELDMS 330

Query: 1753 ---------EPYTVS---------GMARQDSSSEVGENGRSVDQG------GGGSPRKKV 1788
                      P T S         G    D  S    N   VD+G       G     K 
Sbjct: 331  TFIDVEDEKSPQTESCTDSGAENEGSCHSDQMSNDFSNDDGVDEGICLETNSGTEKISKS 390

Query: 1789 ALTEN---YELVGVIVHSGQAHAGHYYSFIKDRRGCGKGKWYKFNDTVIEEFDLNDETLE 1845
             L +N   YEL  V+VHSG A  GHYY+ IK        +WY FND  +      D    
Sbjct: 391  GLEKNSLIYELFSVMVHSGSAAGGHYYACIK---SFSDEQWYSFNDQHVSRITQEDIK-- 445

Query: 1846 YECFGGEYRPKVYDQTNPYTDVRRRYWNAYMLFYQ 1880
             +  GG    + Y     Y+       NAYML Y+
Sbjct: 446  -KTHGGSSGSRGY-----YSSAFASSTNAYMLIYR 474


>gi|76257392 ubiquitin specific protease 48 isoform b [Homo sapiens]
          Length = 485

 Score =  143 bits (361), Expect = 2e-33
 Identities = 115/394 (29%), Positives = 170/394 (43%), Gaps = 68/394 (17%)

Query: 1518 PPVDSRSSSGFVGLRNGGATCYMNAVFQQLYMQPGLPESLL-------------SVDDDT 1564
            P  + R  + FVGL N GATCY+N   Q  ++   L ++L               + ++ 
Sbjct: 78   PNCERRKKNSFVGLTNLGATCYVNTFLQVWFLNLELRQALYLCPSTCSDYMLGDGIQEEK 137

Query: 1565 DNPDDSVFYQVQSLFGHLMESKLQYYVPENFWKIFKMWNKELYVREQQDAYEF---FTSL 1621
            D    ++   +Q LF  L  S  +Y  P  F K        L   +QQDA EF   F SL
Sbjct: 138  DYEPQTICEHLQYLFALLQNSNRRYIDPSGFVKALG-----LDTGQQQDAQEFSKLFMSL 192

Query: 1622 IDQMDEYLKKMGRDQIFKNTFQGIYSDQKICKDCPHRYEREEAFMALNLGVTSCQSLEIS 1681
            ++      K      I +  F G Y+   +C  C    +    F  L L +   + L   
Sbjct: 193  LEDTLSKQKNPDVRNIVQQQFCGEYAYVTVCNQCGRESKLLSKFYELELNIQGHKQLTDC 252

Query: 1682 LDQFVRGEVLEGSNAYYCEKCKEKRITVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKYD 1741
            + +F++ E LEG N Y+CE C+ K+   ++  + SLP  L + LMRF FD ++G   K +
Sbjct: 253  ISEFLKEEKLEGDNRYFCENCQSKQNATRKIRLLSLPCTLNLQLMRFVFDRQTGHKKKLN 312

Query: 1742 EQIRFPWMLNMEPYTVSGMARQDSSSEVGENGRSVDQGGGGSPRKKVALTENYELVGVIV 1801
              I F  +L+MEPY                    V+  GG         +  YEL  V++
Sbjct: 313  TYIGFSEILDMEPY--------------------VEHKGG---------SYVYELSAVLI 343

Query: 1802 HSG-QAHAGHYYSFIKDRRGCGKGKWYKFNDTVIEEFDLN------DETLEYECFGGEYR 1854
            H G  A++GHY + +KD +    G+WYKFND  IE+ +        +E L         +
Sbjct: 344  HRGVSAYSGHYIAHVKDPQ---SGEWYKFNDEDIEKMEGKKLQLGIEEDLAEPSKSQTRK 400

Query: 1855 PKVYDQTNPYTDVRRRYWNAYMLFYQRVSDQNSP 1888
            PK    T+          NAYML Y R+  Q  P
Sbjct: 401  PKCGKGTHCSR-------NAYMLVY-RLQTQEKP 426


>gi|52630449 ubiquitin specific protease 48 isoform a [Homo sapiens]
          Length = 1035

 Score =  143 bits (361), Expect = 2e-33
 Identities = 115/394 (29%), Positives = 170/394 (43%), Gaps = 68/394 (17%)

Query: 1518 PPVDSRSSSGFVGLRNGGATCYMNAVFQQLYMQPGLPESLL-------------SVDDDT 1564
            P  + R  + FVGL N GATCY+N   Q  ++   L ++L               + ++ 
Sbjct: 78   PNCERRKKNSFVGLTNLGATCYVNTFLQVWFLNLELRQALYLCPSTCSDYMLGDGIQEEK 137

Query: 1565 DNPDDSVFYQVQSLFGHLMESKLQYYVPENFWKIFKMWNKELYVREQQDAYEF---FTSL 1621
            D    ++   +Q LF  L  S  +Y  P  F K        L   +QQDA EF   F SL
Sbjct: 138  DYEPQTICEHLQYLFALLQNSNRRYIDPSGFVKALG-----LDTGQQQDAQEFSKLFMSL 192

Query: 1622 IDQMDEYLKKMGRDQIFKNTFQGIYSDQKICKDCPHRYEREEAFMALNLGVTSCQSLEIS 1681
            ++      K      I +  F G Y+   +C  C    +    F  L L +   + L   
Sbjct: 193  LEDTLSKQKNPDVRNIVQQQFCGEYAYVTVCNQCGRESKLLSKFYELELNIQGHKQLTDC 252

Query: 1682 LDQFVRGEVLEGSNAYYCEKCKEKRITVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKYD 1741
            + +F++ E LEG N Y+CE C+ K+   ++  + SLP  L + LMRF FD ++G   K +
Sbjct: 253  ISEFLKEEKLEGDNRYFCENCQSKQNATRKIRLLSLPCTLNLQLMRFVFDRQTGHKKKLN 312

Query: 1742 EQIRFPWMLNMEPYTVSGMARQDSSSEVGENGRSVDQGGGGSPRKKVALTENYELVGVIV 1801
              I F  +L+MEPY                    V+  GG         +  YEL  V++
Sbjct: 313  TYIGFSEILDMEPY--------------------VEHKGG---------SYVYELSAVLI 343

Query: 1802 HSG-QAHAGHYYSFIKDRRGCGKGKWYKFNDTVIEEFDLN------DETLEYECFGGEYR 1854
            H G  A++GHY + +KD +    G+WYKFND  IE+ +        +E L         +
Sbjct: 344  HRGVSAYSGHYIAHVKDPQ---SGEWYKFNDEDIEKMEGKKLQLGIEEDLAEPSKSQTRK 400

Query: 1855 PKVYDQTNPYTDVRRRYWNAYMLFYQRVSDQNSP 1888
            PK    T+          NAYML Y R+  Q  P
Sbjct: 401  PKCGKGTHCSR-------NAYMLVY-RLQTQEKP 426


>gi|150378533 ubiquitin specific peptidase 7 [Homo sapiens]
          Length = 1102

 Score =  119 bits (297), Expect = 5e-26
 Identities = 101/366 (27%), Positives = 162/366 (44%), Gaps = 52/366 (14%)

Query: 1521 DSRSSSGFVGLRNGGATCYMNAVFQQLYMQPGLPESLLSVDDDTDNPDDSVFYQVQSLFG 1580
            DS+  +G+VGL+N GATCYMN++ Q L+    L +++  +  + D+   SV   +Q +F 
Sbjct: 206  DSKKHTGYVGLKNQGATCYMNSLLQTLFFTNQLRKAVYMMPTEGDDSSKSVPLALQRVFY 265

Query: 1581 HLMESKLQYYVPENFWKIFKMWNKE-LYVREQQDAYEFFTSLIDQMDEYLKKMGRDQIFK 1639
             L  S      P    K+ K +  E L    Q D  E    L+D ++  +K    +    
Sbjct: 266  ELQHSD----KPVGTKKLTKSFGWETLDSFMQHDVQELCRVLLDNVENKMKGTCVEGTIP 321

Query: 1640 NTFQGIYSDQKICKDCPHRYEREEAFMALNLGVTSCQSLEISLDQFVRGEVLEGSNAYYC 1699
              F+G       CK+  +R +R E +  + L +   +++  S   +V  E L+G N Y  
Sbjct: 322  KLFRGKMVSYIQCKEVDYRSDRREDYYDIQLSIKGKKNIFESFVDYVAVEQLDGDNKYDA 381

Query: 1700 EK--CKEKRITVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKYDEQIRFPWMLNMEPYTV 1757
             +   +E    VK     +LP VL + LMRF +D ++ ++IK +++  FP  L ++ +  
Sbjct: 382  GEHGLQEAEKGVK---FLTLPPVLHLQLMRFMYDPQTDQNIKINDRFEFPEQLPLDEF-- 436

Query: 1758 SGMARQDSSSEVGENGRSVDQGGGGSPRKKVALTENYELVGVIVHSGQAHAGHYYSFIKD 1817
              + + D                            NY L  V+VHSG  H GHY  ++  
Sbjct: 437  --LQKTDPKDPA-----------------------NYILHAVLVHSGDNHGGHYVVYLNP 471

Query: 1818 RRGCGKGKWYKFNDTVIEEFDLNDETLEYECFGGEYRPKVYDQTNPYTDVRRRYWNAYML 1877
            +   G GKW KF+D V+      +E +E+   G +    V           R   NAYML
Sbjct: 472  K---GDGKWCKFDDDVVSRC-TKEEAIEHNYGGHDDDLSV-----------RHCTNAYML 516

Query: 1878 FYQRVS 1883
             Y R S
Sbjct: 517  VYIRES 522


>gi|41055953 ubiquitin thioesterase 40 [Homo sapiens]
          Length = 1247

 Score =  115 bits (287), Expect = 7e-25
 Identities = 85/312 (27%), Positives = 132/312 (42%), Gaps = 39/312 (12%)

Query: 1517 LPPVDSRSSSGFVGLRNGGATCYMNAVFQQLYMQPGLPESLLSVD-------DDTDNPDD 1569
            L P   R  +   G+RN G TCY+N++ Q L+  P   E+L S+        +D D PD 
Sbjct: 41   LEPPAPREFTNLSGIRNQGGTCYLNSLLQTLHFTPEFREALFSLGPEELGLFEDKDKPDA 100

Query: 1570 SVFY---QVQSLFGHLMESKLQYYVPENFWKIFKMWNKELYVREQQDAYEFFTSLIDQMD 1626
             V     Q+Q LF  L+    +     +    F  W     +R Q D  E    L   ++
Sbjct: 101  KVRIIPLQLQRLFAQLLLLDQEAASTADLTDSFG-WTSNEEMR-QHDVQELNRILFSALE 158

Query: 1627 EYLKKMGRDQIFKNTFQGIYSDQKICKDCPHRYEREEAFMALNLGVTSCQSLEISL-DQF 1685
              L       +    + G   +Q +CK+C +  ER+E F+ L + V +   LE +L + +
Sbjct: 159  TSLVGTSGHDLIYRLYHGTIVNQIVCKECKNVSERQEDFLDLTVAVKNVSGLEDALWNMY 218

Query: 1686 VRGEVLEGSNAYYCEKCKEKRITVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKYDEQIR 1745
            V  EV +  N Y+C  C       K   ++ LP  L + L+RF FD+      K      
Sbjct: 219  VEEEVFDCDNLYHCGTCDRLVKAAKSAKLRKLPPFLTVSLLRFNFDFVKCERYKETSCYT 278

Query: 1746 FPWMLNMEPYTVSGMARQDSSSEVGENGRSVDQGGGGSPRKKVALTENYELVGVIVHSGQ 1805
            FP  +N++P+           SE+ +                  L   Y+L  VI+H G 
Sbjct: 279  FPLRINLKPFC--------EQSELDD------------------LEYIYDLFSVIIHKGG 312

Query: 1806 AHAGHYYSFIKD 1817
             + GHY+ +IKD
Sbjct: 313  CYGGHYHVYIKD 324


>gi|122114651 ubiquitin specific peptidase 36 [Homo sapiens]
          Length = 1123

 Score =  103 bits (258), Expect = 2e-21
 Identities = 104/406 (25%), Positives = 161/406 (39%), Gaps = 85/406 (20%)

Query: 1530 GLRNGGATCYMNAVFQQLYMQPGLPESLLSVDDDTDNPDDSVFYQVQSLFGHLMESKLQY 1589
            GL N G TC++NA  Q L   P L   LLS +        S F  +  +  H++++    
Sbjct: 123  GLHNLGNTCFLNATIQCLTYTPPLANYLLSKEHARSCHQGS-FCMLCVMQNHIVQAFANS 181

Query: 1590 ---YVPENFWKIFKMWNKELYVREQQDAYEFFTSLIDQMDEYL----KKMGRDQ----IF 1638
                 P +F +  K   +      Q+DA+EF    ID M +       K+ R      + 
Sbjct: 182  GNAIKPVSFIRDLKKIARHFRFGNQEDAHEFLRYTIDAMQKACLNGCAKLDRQTQATTLV 241

Query: 1639 KNTFQGIYSDQKICKDCPHRYEREEAFMALNLGVTSCQSLEISLDQFVRGEVLEGSNAYY 1698
               F G    +  C  C    +  + ++ + L +    ++  +L+ FV+ +VL G NAY 
Sbjct: 242  HQIFGGYLRSRVKCSVCKSVSDTYDPYLDVALEIRQAANIVRALELFVKADVLSGENAYM 301

Query: 1699 CEKCKEKRITVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKYDEQIRFPWMLNMEPYTVS 1758
            C KCK+K    KR  I    +VL + L RF  ++  G   K  + + +P  LN+ PY   
Sbjct: 302  CAKCKKKVPASKRFTIHRTSNVLTLSLKRFA-NFSGG---KITKDVGYPEFLNIRPYMSQ 357

Query: 1759 GMARQDSSSEVGENGRSVDQGGGGSPRKKVALTENYELVGVIVHSG-QAHAGHYYSFIKD 1817
                         NG  V                 Y L  V+VHSG   HAGHYY ++K 
Sbjct: 358  ------------NNGDPV----------------MYGLYAVLVHSGYSCHAGHYYCYVK- 388

Query: 1818 RRGCGKGKWYKFNDTVIEEFDLNDETLEYECFGGEYRPKVYDQTNPYTDVRRRYWNAYML 1877
                  G+WY+ ND+++   ++                 V +Q             AY+L
Sbjct: 389  ---ASNGQWYQMNDSLVHSSNVK---------------VVLNQ------------QAYVL 418

Query: 1878 FYQRVSDQNSPVLPKKSRVSVVRQEAEDLSLSAPSSPEISPQSSPR 1923
            FY R+         KKS   ++ +     S S P  P + P  S +
Sbjct: 419  FYLRIPGS------KKSPEGLISRTG---SSSLPGRPSVIPDHSKK 455


>gi|197116355 ubiquitin specific peptidase 46 isoform 2 [Homo sapiens]
          Length = 359

 Score =  101 bits (252), Expect = 8e-21
 Identities = 98/379 (25%), Positives = 156/379 (41%), Gaps = 75/379 (19%)

Query: 1528 FVGLRNGGATCYMNAVFQQLYMQPGLPESLLSVDDDTDNPDDSVFYQVQSLFGHLMESKL 1587
            + GL N G TCY N+V Q LY      E++L+         +++   +  LF  +   K 
Sbjct: 27   YFGLVNFGNTCYCNSVLQALYFCRPFRENVLAYKAQ-QKKKENLLTCLADLFHSIATQKK 85

Query: 1588 QYYV--PENFWKIFKMWNKELYVREQQDAYEFFTSLI----DQMDEYLKKMGRDQIFKN- 1640
            +  V  P+ F    +  N       QQDA+EF   L+    D + E  K+  ++   KN 
Sbjct: 86   KVGVIPPKKFISRLRKENDLFDNYMQQDAHEFLNYLLNTIADILQEEKKQEKQNGKLKNG 145

Query: 1641 ------------------TFQGIYSDQKICKDCPHRYEREEAFMALNLGVTSCQSLEISL 1682
                               FQG  +++  C +C     ++E F+ L++ V    S+   L
Sbjct: 146  NMNEPAENNKPELTWVHEIFQGTLTNETRCLNCETVSSKDEDFLDLSVDVEQNTSITHCL 205

Query: 1683 DQFVRGEVLEGSNAYYCEKCKEKRITVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKYDE 1742
              F   E L     YYCE C  K+   KR  +K LP +L +HL RF +  +  R  K   
Sbjct: 206  RDFSNTETLCSEQKYYCETCCSKQEAQKRMRVKKLPMILALHLKRFKYMEQLHRYTKLSY 265

Query: 1743 QIRFPWMLNMEPYTVSGMARQDSSSEVGENGRSVDQGGGGSPRKKVALTENYELVGVIVH 1802
            ++ FP  L +           ++SS+                   V L   Y+LV V+VH
Sbjct: 266  RVVFPLELRLF----------NTSSDA------------------VNLDRMYDLVAVVVH 297

Query: 1803 SGQA-HAGHYYSFIKDRRGCGKGKWYKFNDTVIEEFDLNDETLEYECFGGEYRPKVYDQT 1861
             G   + GHY + +K       G W  F+D ++E+ D   + +E          + Y  T
Sbjct: 298  CGSGPNRGHYITIVKSH-----GFWLLFDDDIVEKIDA--QAIE----------EFYGLT 340

Query: 1862 NPYTDVRRRYWNAYMLFYQ 1880
               +D+ +   + Y+LFYQ
Sbjct: 341  ---SDISKNSESGYILFYQ 356


>gi|31377709 ubiquitin specific peptidase 46 isoform 1 [Homo sapiens]
          Length = 366

 Score =  101 bits (252), Expect = 8e-21
 Identities = 98/379 (25%), Positives = 156/379 (41%), Gaps = 75/379 (19%)

Query: 1528 FVGLRNGGATCYMNAVFQQLYMQPGLPESLLSVDDDTDNPDDSVFYQVQSLFGHLMESKL 1587
            + GL N G TCY N+V Q LY      E++L+         +++   +  LF  +   K 
Sbjct: 34   YFGLVNFGNTCYCNSVLQALYFCRPFRENVLAYKAQ-QKKKENLLTCLADLFHSIATQKK 92

Query: 1588 QYYV--PENFWKIFKMWNKELYVREQQDAYEFFTSLI----DQMDEYLKKMGRDQIFKN- 1640
            +  V  P+ F    +  N       QQDA+EF   L+    D + E  K+  ++   KN 
Sbjct: 93   KVGVIPPKKFISRLRKENDLFDNYMQQDAHEFLNYLLNTIADILQEEKKQEKQNGKLKNG 152

Query: 1641 ------------------TFQGIYSDQKICKDCPHRYEREEAFMALNLGVTSCQSLEISL 1682
                               FQG  +++  C +C     ++E F+ L++ V    S+   L
Sbjct: 153  NMNEPAENNKPELTWVHEIFQGTLTNETRCLNCETVSSKDEDFLDLSVDVEQNTSITHCL 212

Query: 1683 DQFVRGEVLEGSNAYYCEKCKEKRITVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKYDE 1742
              F   E L     YYCE C  K+   KR  +K LP +L +HL RF +  +  R  K   
Sbjct: 213  RDFSNTETLCSEQKYYCETCCSKQEAQKRMRVKKLPMILALHLKRFKYMEQLHRYTKLSY 272

Query: 1743 QIRFPWMLNMEPYTVSGMARQDSSSEVGENGRSVDQGGGGSPRKKVALTENYELVGVIVH 1802
            ++ FP  L +           ++SS+                   V L   Y+LV V+VH
Sbjct: 273  RVVFPLELRLF----------NTSSDA------------------VNLDRMYDLVAVVVH 304

Query: 1803 SGQA-HAGHYYSFIKDRRGCGKGKWYKFNDTVIEEFDLNDETLEYECFGGEYRPKVYDQT 1861
             G   + GHY + +K       G W  F+D ++E+ D   + +E          + Y  T
Sbjct: 305  CGSGPNRGHYITIVKSH-----GFWLLFDDDIVEKIDA--QAIE----------EFYGLT 347

Query: 1862 NPYTDVRRRYWNAYMLFYQ 1880
               +D+ +   + Y+LFYQ
Sbjct: 348  ---SDISKNSESGYILFYQ 363


>gi|32698815 ubiquitin thiolesterase 12 [Homo sapiens]
          Length = 370

 Score =  100 bits (248), Expect = 2e-20
 Identities = 103/398 (25%), Positives = 162/398 (40%), Gaps = 78/398 (19%)

Query: 1509 ALTKEFDYLPPVDSRSSSGFVGLRNGGATCYMNAVFQQLYMQPGLPESLLSVDDDTDNPD 1568
            AL KE   + P     +  + GL N G TCY N+V Q LY      E +L+         
Sbjct: 22   ALEKE---IGPEQFPVNEHYFGLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQP-RKK 77

Query: 1569 DSVFYQVQSLFGHLMESKLQYYV--PENFWKIFKMWNKELYVREQQDAYEFFTSLIDQMD 1626
            +S+   +  LF  +   K +  V  P+ F    +  N+      QQDA+EF   L++ + 
Sbjct: 78   ESLLTCLADLFHSIATQKKKVGVIPPKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIA 137

Query: 1627 EYL-------KKMGR------DQIFKNT----------FQGIYSDQKICKDCPHRYEREE 1663
            + L       K+ GR      D    N+          FQG  +++  C  C     ++E
Sbjct: 138  DILQEERKQEKQNGRLPNGNIDNENNNSTPDPTWVDEIFQGTLTNETRCLTCETISSKDE 197

Query: 1664 AFMALNLGVTSCQSLEISLDQFVRGEVLEGSNAYYCEKCKEKRITVKRTCIKSLPSVLVI 1723
             F+ L++ V    S+   L  F   E L     YYCE+C+ K+   KR  +K LP +L +
Sbjct: 198  DFLDLSVDVEQNTSITHCLRGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILAL 257

Query: 1724 HLMRFGFDWESGRSIKYDEQIRFPWMLNMEPYTVSGMARQDSSSEVGENGRSVDQGGGGS 1783
            HL RF +  +  R  K   ++ FP  L +  +  SG A                      
Sbjct: 258  HLKRFKYMDQLHRYTKLSYRVVFP--LELRLFNTSGDATNPD------------------ 297

Query: 1784 PRKKVALTENYELVGVIVHSGQA-HAGHYYSFIKDRRGCGKGKWYKFNDTVIEEFDLNDE 1842
                      Y+LV V+VH G   + GHY + +K         W  F+D ++E+ D   +
Sbjct: 298  --------RMYDLVAVVVHCGSGPNRGHYIAIVKSH-----DFWLLFDDDIVEKIDA--Q 342

Query: 1843 TLEYECFGGEYRPKVYDQTNPYTDVRRRYWNAYMLFYQ 1880
             +E          + Y  T   +D+ +   + Y+LFYQ
Sbjct: 343  AIE----------EFYGLT---SDISKNSESGYILFYQ 367


>gi|190684694 ubiquitin specific peptidase 8 [Homo sapiens]
          Length = 1118

 Score = 97.4 bits (241), Expect = 1e-19
 Identities = 96/386 (24%), Positives = 155/386 (40%), Gaps = 78/386 (20%)

Query: 1517 LPPVDSRSSSGFVGLRNGGATCYMNAVFQQLYMQPGLPESL-LSVDDDTDNPDDSVFY-- 1573
            L PV   S     GLRN G TCYMN++ Q L   P L +    +   D  N  + + +  
Sbjct: 765  LNPVFGGSGPALTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKG 824

Query: 1574 QVQSLFGHLMES----KLQYYVPENFWKIFKMWNKELYVREQQDAYEFFTSLIDQMDEYL 1629
            +V   FG +M++    + +Y  P++F       N +     QQD+ E    L+D + E L
Sbjct: 825  EVAEEFGIIMKALWTGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDL 884

Query: 1630 KKMGRDQIFKNT-----------------------------FQGIYSDQKICKDCPHRYE 1660
             K    + +K                               FQG +     C  C  +  
Sbjct: 885  NKADNRKRYKEENNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSR 944

Query: 1661 REEAFMALNLGVTSCQ--SLEISLDQFVRGEVLEGSNAYYCEKCKEKRITVKRTCIKSLP 1718
              EAFM L+L + S    +L+  L  F + E L  +N +YC  C+ +R ++K+  I  LP
Sbjct: 945  TFEAFMYLSLPLASTSKCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLP 1004

Query: 1719 SVLVIHLMRFGFD--WESGRSIKYDEQIRFPW-MLNMEPYTVSGMARQDSSSEVGENGRS 1775
             VL++HL RF +D  W+     K    + FP   L++  Y +                  
Sbjct: 1005 PVLLVHLKRFSYDGRWKQ----KLQTSVDFPLENLDLSQYVI------------------ 1042

Query: 1776 VDQGGGGSPRKKVALTENYELVGVIVHSGQAHAGHYYSFIKDRRGCGKGKWYKFNDTVIE 1835
                    P+  +   + Y L  V  H G    GHY ++ K+     + +W+KF+D  + 
Sbjct: 1043 -------GPKNNL---KKYNLFSVSNHYGGLDGGHYTAYCKN---AARQRWFKFDDHEVS 1089

Query: 1836 EFDLND--ETLEYECFGGEYRPKVYD 1859
            +  ++    +  Y  F     P+V D
Sbjct: 1090 DISVSSVKSSAAYILFYTSLGPRVTD 1115


>gi|190684692 ubiquitin specific peptidase 8 [Homo sapiens]
          Length = 1118

 Score = 97.4 bits (241), Expect = 1e-19
 Identities = 96/386 (24%), Positives = 155/386 (40%), Gaps = 78/386 (20%)

Query: 1517 LPPVDSRSSSGFVGLRNGGATCYMNAVFQQLYMQPGLPESL-LSVDDDTDNPDDSVFY-- 1573
            L PV   S     GLRN G TCYMN++ Q L   P L +    +   D  N  + + +  
Sbjct: 765  LNPVFGGSGPALTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKG 824

Query: 1574 QVQSLFGHLMES----KLQYYVPENFWKIFKMWNKELYVREQQDAYEFFTSLIDQMDEYL 1629
            +V   FG +M++    + +Y  P++F       N +     QQD+ E    L+D + E L
Sbjct: 825  EVAEEFGIIMKALWTGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDL 884

Query: 1630 KKMGRDQIFKNT-----------------------------FQGIYSDQKICKDCPHRYE 1660
             K    + +K                               FQG +     C  C  +  
Sbjct: 885  NKADNRKRYKEENNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSR 944

Query: 1661 REEAFMALNLGVTSCQ--SLEISLDQFVRGEVLEGSNAYYCEKCKEKRITVKRTCIKSLP 1718
              EAFM L+L + S    +L+  L  F + E L  +N +YC  C+ +R ++K+  I  LP
Sbjct: 945  TFEAFMYLSLPLASTSKCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLP 1004

Query: 1719 SVLVIHLMRFGFD--WESGRSIKYDEQIRFPW-MLNMEPYTVSGMARQDSSSEVGENGRS 1775
             VL++HL RF +D  W+     K    + FP   L++  Y +                  
Sbjct: 1005 PVLLVHLKRFSYDGRWKQ----KLQTSVDFPLENLDLSQYVI------------------ 1042

Query: 1776 VDQGGGGSPRKKVALTENYELVGVIVHSGQAHAGHYYSFIKDRRGCGKGKWYKFNDTVIE 1835
                    P+  +   + Y L  V  H G    GHY ++ K+     + +W+KF+D  + 
Sbjct: 1043 -------GPKNNL---KKYNLFSVSNHYGGLDGGHYTAYCKN---AARQRWFKFDDHEVS 1089

Query: 1836 EFDLND--ETLEYECFGGEYRPKVYD 1859
            +  ++    +  Y  F     P+V D
Sbjct: 1090 DISVSSVKSSAAYILFYTSLGPRVTD 1115


>gi|190684690 ubiquitin specific peptidase 8 [Homo sapiens]
          Length = 1118

 Score = 97.4 bits (241), Expect = 1e-19
 Identities = 96/386 (24%), Positives = 155/386 (40%), Gaps = 78/386 (20%)

Query: 1517 LPPVDSRSSSGFVGLRNGGATCYMNAVFQQLYMQPGLPESL-LSVDDDTDNPDDSVFY-- 1573
            L PV   S     GLRN G TCYMN++ Q L   P L +    +   D  N  + + +  
Sbjct: 765  LNPVFGGSGPALTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKG 824

Query: 1574 QVQSLFGHLMES----KLQYYVPENFWKIFKMWNKELYVREQQDAYEFFTSLIDQMDEYL 1629
            +V   FG +M++    + +Y  P++F       N +     QQD+ E    L+D + E L
Sbjct: 825  EVAEEFGIIMKALWTGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDL 884

Query: 1630 KKMGRDQIFKNT-----------------------------FQGIYSDQKICKDCPHRYE 1660
             K    + +K                               FQG +     C  C  +  
Sbjct: 885  NKADNRKRYKEENNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSR 944

Query: 1661 REEAFMALNLGVTSCQ--SLEISLDQFVRGEVLEGSNAYYCEKCKEKRITVKRTCIKSLP 1718
              EAFM L+L + S    +L+  L  F + E L  +N +YC  C+ +R ++K+  I  LP
Sbjct: 945  TFEAFMYLSLPLASTSKCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLP 1004

Query: 1719 SVLVIHLMRFGFD--WESGRSIKYDEQIRFPW-MLNMEPYTVSGMARQDSSSEVGENGRS 1775
             VL++HL RF +D  W+     K    + FP   L++  Y +                  
Sbjct: 1005 PVLLVHLKRFSYDGRWKQ----KLQTSVDFPLENLDLSQYVI------------------ 1042

Query: 1776 VDQGGGGSPRKKVALTENYELVGVIVHSGQAHAGHYYSFIKDRRGCGKGKWYKFNDTVIE 1835
                    P+  +   + Y L  V  H G    GHY ++ K+     + +W+KF+D  + 
Sbjct: 1043 -------GPKNNL---KKYNLFSVSNHYGGLDGGHYTAYCKN---AARQRWFKFDDHEVS 1089

Query: 1836 EFDLND--ETLEYECFGGEYRPKVYD 1859
            +  ++    +  Y  F     P+V D
Sbjct: 1090 DISVSSVKSSAAYILFYTSLGPRVTD 1115


>gi|79750944 ubiquitin specific peptidase 42 [Homo sapiens]
          Length = 1316

 Score = 96.7 bits (239), Expect = 3e-19
 Identities = 82/328 (25%), Positives = 142/328 (43%), Gaps = 61/328 (18%)

Query: 1530 GLRNGGATCYMNAVFQQLYMQPGLPESLLSVDDDTDNPDDSVFYQVQSLFGHLMES---- 1585
            GL+N G TC+ NA  Q L   P L   +LS  + +       F  + ++  H+ ++    
Sbjct: 112  GLQNLGNTCFANAALQCLTYTPPLANYMLS-HEHSKTCHAEGFCMMCTMQAHITQALSNP 170

Query: 1586 ----KLQYYVPENFWKIFKMWNKELYVREQQDAYEFFTSLIDQMDEYLKKMGRDQIFKNT 1641
                K  + + E      +   +      Q+DA+EF    +D M +     G +++ ++T
Sbjct: 171  GDVIKPMFVINE-----MRRIARHFRFGNQEDAHEFLQYTVDAMQKACLN-GSNKLDRHT 224

Query: 1642 ---------FQGIYSDQKICKDCPHRYEREEAFMALNLGVTSCQSLEISLDQFVRGEVLE 1692
                     F G    +  C +C    +  + ++ + L + + QS+  +L+QFV+ E L+
Sbjct: 225  QATTLVCQIFGGYLRSRVKCLNCKGVSDTFDPYLDITLEIKAAQSVNKALEQFVKPEQLD 284

Query: 1693 GSNAYYCEKCKEKRITVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKYDEQIRFPWMLNM 1752
            G N+Y C KCK+     KR  I    +VL + L RF  ++  G+  K    +++P  L++
Sbjct: 285  GENSYKCSKCKKMVPASKRFTIHRSSNVLTLSLKRFA-NFTGGKIAK---DVKYPEYLDI 340

Query: 1753 EPYTVSGMARQDSSSEVGENGRSVDQGGGGSPRKKVALTENYELVGVIVHSG-QAHAGHY 1811
             PY                NG  +                 Y L  V+VH+G   HAGHY
Sbjct: 341  RPYMSQ------------PNGEPI----------------VYVLYAVLVHTGFNCHAGHY 372

Query: 1812 YSFIKDRRGCGKGKWYKFNDTVIEEFDL 1839
            + +IK       G WY+ ND+++   D+
Sbjct: 373  FCYIK----ASNGLWYQMNDSIVSTSDI 396


>gi|239757637 PREDICTED: ubiquitin specific peptidase 41 [Homo
            sapiens]
          Length = 344

 Score = 95.9 bits (237), Expect = 4e-19
 Identities = 85/325 (26%), Positives = 133/325 (40%), Gaps = 35/325 (10%)

Query: 1517 LPPVDSRSSSGFVGLRNGGATCYMNAVFQQLYMQPGLPESL--LSVDDDTDNPDDSVFYQ 1574
            +P +      G VGL N G TC +N++ Q   M       L  ++V    D    SV +Q
Sbjct: 9    VPKISWDYRHGLVGLHNIGQTCCLNSLIQVFVMNVDFARILKRITVPRGADEQRRSVPFQ 68

Query: 1575 VQSLFGHLMESKLQYYVPENFWKIFKMWNKELYVREQQDAYEFFTSLIDQMDEYLKKMGR 1634
            +  L   + +S+ +   P       + +N  L+V  Q DA + +  L + + + +  +  
Sbjct: 69   MLLLLEKMQDSRQKAVWPLELAYCLQKYNVPLFV--QHDAAQLYLKLWNLIKDQIADVHL 126

Query: 1635 DQIFKNTFQGIYSDQKICKDCPHRYEREEAFMALNLGVTSCQS-----LEISLDQFVRGE 1689
             +  +  +     D  IC DC     R  + + L L      S     LE +L  F +  
Sbjct: 127  VERLQALYMIRVKDSLICLDCAMESSRNSSMLTLRLSFFDVDSKPLKTLEDALHCFFQPR 186

Query: 1690 VLEGSNAYYCEKCKEKRITVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKYDEQIRFPWM 1749
             L   +  +CE C +K    +   +  LP  L IHLMRF     + ++ K    + FP  
Sbjct: 187  ELSSKSKCFCENCGKKTRGKQVLKLTHLPQTLTIHLMRFSI--RNSQTRKICHSLYFPQS 244

Query: 1750 LNMEPYTVSGMARQDSSSEVGENGRSVDQGGGGSPRKKVALTENYELVGVIVHSGQAHAG 1809
            L+     +  M R+   +E        +Q GG            YEL  VI H G A +G
Sbjct: 245  LDFS--QILPMKRESCDAE--------EQSGG-----------QYELFAVIAHVGMADSG 283

Query: 1810 HYYSFIKDRRGCGKGKWYKFNDTVI 1834
            HY  +I   R    GKW+ FND+ I
Sbjct: 284  HYCVYI---RSAVDGKWFCFNDSNI 305


>gi|169215723 PREDICTED: ubiquitin specific peptidase 41 [Homo
            sapiens]
          Length = 346

 Score = 95.5 bits (236), Expect = 6e-19
 Identities = 84/315 (26%), Positives = 130/315 (41%), Gaps = 35/315 (11%)

Query: 1527 GFVGLRNGGATCYMNAVFQQLYMQPGLPESL--LSVDDDTDNPDDSVFYQVQSLFGHLME 1584
            G VGL N G TC +N++ Q   M       L  ++V    D    SV +Q+  L   + +
Sbjct: 42   GLVGLHNIGQTCCLNSLIQVFVMNVDFARILKRITVPRGADEQRRSVPFQMLLLLEKMQD 101

Query: 1585 SKLQYYVPENFWKIFKMWNKELYVREQQDAYEFFTSLIDQMDEYLKKMGRDQIFKNTFQG 1644
            S+ +   P       + +N  L+V  Q DA + +  L + + + +  +   +  +  +  
Sbjct: 102  SRQKAVWPLELAYCLQKYNVPLFV--QHDAAQLYLKLWNLIKDQIADVHLVERLQALYMI 159

Query: 1645 IYSDQKICKDCPHRYEREEAFMALNLGVTSCQS-----LEISLDQFVRGEVLEGSNAYYC 1699
               D  IC DC     R  + + L L      S     LE +L  F +   L   +  +C
Sbjct: 160  RMKDSLICLDCAMESSRNSSMLTLRLSFFDVDSKPLKTLEDALHCFFQPRELSSKSKCFC 219

Query: 1700 EKCKEKRITVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKYDEQIRFPWMLNMEPYTVSG 1759
            E C +K    +   +  LP  L IHLMRF     + ++ K    + FP  L+     +  
Sbjct: 220  ENCGKKTRGKQVLKLTHLPQTLTIHLMRFSI--RNSQTRKICHSLYFPQSLDFS--QILP 275

Query: 1760 MARQDSSSEVGENGRSVDQGGGGSPRKKVALTENYELVGVIVHSGQAHAGHYYSFIKDRR 1819
            M R+   +E        +Q GG            YEL  VI H G A +GHY  +I   R
Sbjct: 276  MKRESCDAE--------EQSGG-----------QYELFAVIAHVGMADSGHYCVYI---R 313

Query: 1820 GCGKGKWYKFNDTVI 1834
                GKW+ FND+ I
Sbjct: 314  NAVDGKWFCFNDSNI 328


>gi|239746654 PREDICTED: ubiquitin specific protease 41 [Homo sapiens]
          Length = 347

 Score = 95.5 bits (236), Expect = 6e-19
 Identities = 84/315 (26%), Positives = 130/315 (41%), Gaps = 35/315 (11%)

Query: 1527 GFVGLRNGGATCYMNAVFQQLYMQPGLPESL--LSVDDDTDNPDDSVFYQVQSLFGHLME 1584
            G VGL N G TC +N++ Q   M       L  ++V    D    SV +Q+  L   + +
Sbjct: 42   GLVGLHNIGQTCCLNSLIQVFVMNVDFARILKRITVPRGADEQRRSVPFQMLLLLEKMQD 101

Query: 1585 SKLQYYVPENFWKIFKMWNKELYVREQQDAYEFFTSLIDQMDEYLKKMGRDQIFKNTFQG 1644
            S+ +   P       + +N  L+V  Q DA + +  L + + + +  +   +  +  +  
Sbjct: 102  SRQKAVWPLELAYCLQKYNVPLFV--QHDAAQLYLKLWNLIKDQIADVHLVERLQALYMI 159

Query: 1645 IYSDQKICKDCPHRYEREEAFMALNLGVTSCQS-----LEISLDQFVRGEVLEGSNAYYC 1699
               D  IC DC     R  + + L L      S     LE +L  F +   L   +  +C
Sbjct: 160  RMKDSLICLDCAMESSRNSSMLTLRLSFFDVDSKPLKTLEDALHCFFQPRELSSKSKCFC 219

Query: 1700 EKCKEKRITVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKYDEQIRFPWMLNMEPYTVSG 1759
            E C +K    +   +  LP  L IHLMRF     + ++ K    + FP  L+     +  
Sbjct: 220  ENCGKKTRGKQVLKLTHLPQTLTIHLMRFSI--RNSQTRKICHSLYFPQSLDFS--QILP 275

Query: 1760 MARQDSSSEVGENGRSVDQGGGGSPRKKVALTENYELVGVIVHSGQAHAGHYYSFIKDRR 1819
            M R+   +E        +Q GG            YEL  VI H G A +GHY  +I   R
Sbjct: 276  MKRESCDAE--------EQSGG-----------QYELFAVIAHVGMADSGHYCVYI---R 313

Query: 1820 GCGKGKWYKFNDTVI 1834
                GKW+ FND+ I
Sbjct: 314  NAVDGKWFCFNDSNI 328


>gi|32313610 ubiquitin specific protease 18 [Homo sapiens]
          Length = 372

 Score = 95.5 bits (236), Expect = 6e-19
 Identities = 94/361 (26%), Positives = 150/361 (41%), Gaps = 45/361 (12%)

Query: 1483 MLADSS--PSNLQIIIKELLSMHHQPDPALTKEFDYLPPVDSRSSSGFVGLRNGGATCYM 1540
            +LA+SS  P++L+   +E  +M  +      + +DY          G VGL N G TC +
Sbjct: 15   ILAESSQSPADLEEKKEEDSNMKREQPRERPRAWDY--------PHGLVGLHNIGQTCCL 66

Query: 1541 NAVFQQLYMQPGLPESL--LSVDDDTDNPDDSVFYQVQSLFGHLMESKLQYYVPENFWKI 1598
            N++ Q   M       L  ++V    D    SV +Q+  L   + +S+ +   P      
Sbjct: 67   NSLIQVFVMNVDFTRILKRITVPRGADEQRRSVPFQMLLLLEKMQDSRQKAVRPLELAYC 126

Query: 1599 FKMWNKELYVREQQDAYEFFTSLIDQMDEYLKKMGRDQIFKNTFQGIYSDQKICKDCPHR 1658
             +  N  L+V  Q DA + +  L + + + +  +   +  +  +     D  IC DC   
Sbjct: 127  LQKCNVPLFV--QHDAAQLYLKLWNLIKDQITDVHLVERLQALYTIRVKDSLICVDCAME 184

Query: 1659 YEREEAFMALNLGVTSCQS-----LEISLDQFVRGEVLEGSNAYYCEKCKEKRITVKRTC 1713
              R  + + L L +    S     LE +L  F +   L   +  +CE C +K    +   
Sbjct: 185  SSRNSSMLTLPLSLFDVDSKPLKTLEDALHCFFQPRELSSKSKCFCENCGKKTRGKQVLK 244

Query: 1714 IKSLPSVLVIHLMRFGFDWESGRSIKYDEQIRFPWMLNMEPYTVSGMARQDSSSEVGENG 1773
            +  LP  L IHLMRF     + ++ K    + FP  L+     +  M R+   +E     
Sbjct: 245  LTHLPQTLTIHLMRFSI--RNSQTRKICHSLYFPQSLDFS--QILPMKRESCDAE----- 295

Query: 1774 RSVDQGGGGSPRKKVALTENYELVGVIVHSGQAHAGHYYSFIKDRRGCGKGKWYKFNDTV 1833
               +Q GG            YEL  VI H G A +GHY  +I   R    GKW+ FND+ 
Sbjct: 296  ---EQSGG-----------QYELFAVIAHVGMADSGHYCVYI---RNAVDGKWFCFNDSN 338

Query: 1834 I 1834
            I
Sbjct: 339  I 339


>gi|239742276 PREDICTED: hypothetical protein XP_002342471 [Homo
            sapiens]
          Length = 530

 Score = 92.4 bits (228), Expect = 5e-18
 Identities = 80/327 (24%), Positives = 146/327 (44%), Gaps = 50/327 (15%)

Query: 1518 PPVDSRSSSGF-VGLRNGGATCYMNAVFQQLYMQPGLPESLLSVDDDTDNPDDSVFYQVQ 1576
            PP+ SR  +    GL+N G TCY+NA  Q L  +P L   +L   + +          + 
Sbjct: 68   PPLSSRRPAAVGAGLQNMGNTCYVNASLQCLTYKPPLANYML-FREHSQTCHRHKGCMLC 126

Query: 1577 SLFGHLMESKLQYYVPENFWKIFKMWNKELYVREQQDAYEFFTSLIDQMDEYL----KKM 1632
            ++  H+  +    ++P +  +  +      +  +Q+DA+EF    +D M +      K++
Sbjct: 127  TMQAHITRA---LHIPGHVIQPSQALAAGFHRGKQEDAHEFLMFTVDAMRKACLPGHKQV 183

Query: 1633 GRDQ----IFKNTFQGIYSDQKICKDCPHRYEREEAFMALNLGVTSCQSLEISLDQFVRG 1688
             R      +    F G +  Q  C  C    +  + ++ + L + + QS++ +L+Q V+ 
Sbjct: 184  DRHSKDTTLIHQIFGGYWRSQIKCLHCHGISDTFDPYLDIALDIQAAQSVQQALEQLVKP 243

Query: 1689 EVLEGSNAYYCEKCKEKRITVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKYDEQIRFPW 1748
            E L G NAY+C  C ++    K   + +   VL++ L RF          K  + +++P 
Sbjct: 244  EELNGENAYHCGVCLQRAPASKTLTLHNSAKVLILVLKRF----PDVTGNKIAKNVQYPE 299

Query: 1749 MLNMEPYTVSGMARQDSSSEVGENGRSVDQGGGGSPRKKVALTENYELVGVIVHSG-QAH 1807
             L+M+PY    M++Q++   V                        Y L  V+VH+G   H
Sbjct: 300  CLDMQPY----MSQQNTGPLV------------------------YVLYAVLVHAGWSCH 331

Query: 1808 AGHYYSFIKDRRGCGKGKWYKFNDTVI 1834
             GHY S++K +    +G+WYK +D  +
Sbjct: 332  NGHYSSYVKAQ----EGQWYKMDDAEV 354


>gi|153792150 deubiquitinating enzyme 3 [Homo sapiens]
          Length = 530

 Score = 91.7 bits (226), Expect = 8e-18
 Identities = 82/332 (24%), Positives = 140/332 (42%), Gaps = 59/332 (17%)

Query: 1517 LPPVDSRSSSGFVGLRNGGATCYMNAVFQQLYMQPGLPESLLSVDDDT--DNPDDSVFYQ 1574
            LP    R ++   GL+N G TCY NA  Q L   P L   +LS +       P   +   
Sbjct: 68   LPLSSRRPAAVGAGLQNMGNTCYENASLQCLTYTPPLANYMLSREHSQTCQRPKCCMLCT 127

Query: 1575 VQSLFGHLMESKLQYYVPENFWKIFKMWNKELYVREQQDAYEFFTSLID----------- 1623
            +Q+     + S      P       +      +  +Q+DA+EF    +D           
Sbjct: 128  MQAHITWALHSPGHVIQPS------QALAAGFHRGKQEDAHEFLMFTVDAMKKACLPGHK 181

Query: 1624 QMDEYLKKMGRDQIFKNTFQGIYSDQKICKDCPHRYEREEAFMALNLGVTSCQSLEISLD 1683
            Q+D + K      +    F G +  Q  C  C    +  + ++ + L + + QS++ +L+
Sbjct: 182  QVDHHSKDT---TLIHQIFGGCWRSQIKCLHCHGISDTFDPYLDIALDIQAAQSVKQALE 238

Query: 1684 QFVRGEVLEGSNAYYCEKCKEKRITVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKYDEQ 1743
            Q V+ E L G NAY+C  C ++    K   + +   VL++ L RF          K  + 
Sbjct: 239  QLVKPEELNGENAYHCGLCLQRAPASKTLTLHTSAKVLILVLKRF----SDVTGNKLAKN 294

Query: 1744 IRFPWMLNMEPYTVSGMARQDSSSEVGENGRSVDQGGGGSPRKKVALTENYELVGVIVHS 1803
            +++P  L+M+PY    M++Q++   V                        Y L  V+VH+
Sbjct: 295  VQYPECLDMQPY----MSQQNTGPLV------------------------YVLYAVLVHA 326

Query: 1804 G-QAHAGHYYSFIKDRRGCGKGKWYKFNDTVI 1834
            G   H GHY+S++K +    +G+WYK +D  +
Sbjct: 327  GWSCHDGHYFSYVKAQ----EGQWYKMDDAKV 354


>gi|239758075 PREDICTED: similar to deubiquitinating enzyme DUB1 [Homo
            sapiens]
          Length = 530

 Score = 90.9 bits (224), Expect = 1e-17
 Identities = 80/330 (24%), Positives = 144/330 (43%), Gaps = 55/330 (16%)

Query: 1517 LPPVDSRSSSGFVGLRNGGATCYMNAVFQQLYMQPGLPESLLSVDDDTDNPDDSVFYQVQ 1576
            LP    R ++   GL+N G TCY+NA  Q L   P L   +LS  + +          + 
Sbjct: 68   LPLSSRRPAAVGAGLQNMGNTCYVNASLQCLTYTPPLANYMLS-REHSQTCHRHKGCMLC 126

Query: 1577 SLFGHLMESKLQYYVPENFWKIFKMWNKELYVREQQDAYEFFTSLID-----------QM 1625
            ++  H+  +    + P +  +  +      +  +Q+DA+EF    +D           Q+
Sbjct: 127  TMQAHITRA---LHNPGHVIQPSQALAAGFHRGKQEDAHEFLMFTVDAMKKACLPGHKQV 183

Query: 1626 DEYLKKMGRDQIFKNTFQGIYSDQKICKDCPHRYEREEAFMALNLGVTSCQSLEISLDQF 1685
            D + K      +    F G +  Q  C  C    +  + ++ + L + + QS++ +L+Q 
Sbjct: 184  DHHSKDT---TLIHQIFGGYWRSQIKCLHCHGISDTFDPYLDIALDIQAAQSVQQALEQL 240

Query: 1686 VRGEVLEGSNAYYCEKCKEKRITVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKYDEQIR 1745
            V+ E L G NAY+C  C ++    K   + +   VL++ L RF          K  + ++
Sbjct: 241  VKPEELNGENAYHCGVCLQRAPASKTLTLHTSAKVLILVLKRF----SDVTGNKIAKNVQ 296

Query: 1746 FPWMLNMEPYTVSGMARQDSSSEVGENGRSVDQGGGGSPRKKVALTENYELVGVIVHSG- 1804
            +P  L+M+PY    M++Q++   V                        Y L  V+VH+G 
Sbjct: 297  YPECLDMQPY----MSQQNTGPLV------------------------YVLYAVLVHAGW 328

Query: 1805 QAHAGHYYSFIKDRRGCGKGKWYKFNDTVI 1834
              H GHY+S++K +    +G+WYK +D  +
Sbjct: 329  SCHNGHYFSYVKAQ----EGQWYKMDDAEV 354


>gi|239742297 PREDICTED: hypothetical protein XP_002342480 [Homo
            sapiens]
          Length = 530

 Score = 90.9 bits (224), Expect = 1e-17
 Identities = 80/330 (24%), Positives = 144/330 (43%), Gaps = 55/330 (16%)

Query: 1517 LPPVDSRSSSGFVGLRNGGATCYMNAVFQQLYMQPGLPESLLSVDDDTDNPDDSVFYQVQ 1576
            LP    R ++   GL+N G TCY+NA  Q L   P L   +LS  + +          + 
Sbjct: 68   LPLSSRRPAAVGAGLQNMGNTCYVNASLQCLTYTPPLANYMLS-REHSQTCHRHKGCMLC 126

Query: 1577 SLFGHLMESKLQYYVPENFWKIFKMWNKELYVREQQDAYEFFTSLID-----------QM 1625
            ++  H+  +    + P +  +  +      +  +Q+DA+EF    +D           Q+
Sbjct: 127  TMQAHITRA---LHNPGHVIQPSQALAAGFHRGKQEDAHEFLMFTVDAMKKACLPGHKQV 183

Query: 1626 DEYLKKMGRDQIFKNTFQGIYSDQKICKDCPHRYEREEAFMALNLGVTSCQSLEISLDQF 1685
            D + K      +    F G +  Q  C  C    +  + ++ + L + + QS++ +L+Q 
Sbjct: 184  DHHSKDT---TLIHQIFGGYWRSQIKCLHCHGISDTFDPYLDIALDIQAAQSVQQALEQL 240

Query: 1686 VRGEVLEGSNAYYCEKCKEKRITVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKYDEQIR 1745
            V+ E L G NAY+C  C ++    K   + +   VL++ L RF          K  + ++
Sbjct: 241  VKPEELNGENAYHCGVCLQRAPASKTLTLHTSAKVLILVLKRF----SDVTGNKIAKNVQ 296

Query: 1746 FPWMLNMEPYTVSGMARQDSSSEVGENGRSVDQGGGGSPRKKVALTENYELVGVIVHSG- 1804
            +P  L+M+PY    M++Q++   V                        Y L  V+VH+G 
Sbjct: 297  YPECLDMQPY----MSQQNTGPLV------------------------YVLYAVLVHAGW 328

Query: 1805 QAHAGHYYSFIKDRRGCGKGKWYKFNDTVI 1834
              H GHY+S++K +    +G+WYK +D  +
Sbjct: 329  SCHNGHYFSYVKAQ----EGQWYKMDDAEV 354


>gi|239742287 PREDICTED: hypothetical protein XP_002342475 [Homo
            sapiens]
          Length = 530

 Score = 90.9 bits (224), Expect = 1e-17
 Identities = 80/330 (24%), Positives = 144/330 (43%), Gaps = 55/330 (16%)

Query: 1517 LPPVDSRSSSGFVGLRNGGATCYMNAVFQQLYMQPGLPESLLSVDDDTDNPDDSVFYQVQ 1576
            LP    R ++   GL+N G TCY+NA  Q L   P L   +LS  + +          + 
Sbjct: 68   LPLSSRRPAAVGAGLQNMGNTCYVNASLQCLTYTPPLANYMLS-REHSQTCHRHKGCMLC 126

Query: 1577 SLFGHLMESKLQYYVPENFWKIFKMWNKELYVREQQDAYEFFTSLID-----------QM 1625
            ++  H+  +    + P +  +  +      +  +Q+DA+EF    +D           Q+
Sbjct: 127  TMQAHITRA---LHNPGHVIQPSQALAAGFHRGKQEDAHEFLMFTVDAMKKACLPGHKQV 183

Query: 1626 DEYLKKMGRDQIFKNTFQGIYSDQKICKDCPHRYEREEAFMALNLGVTSCQSLEISLDQF 1685
            D + K      +    F G +  Q  C  C    +  + ++ + L + + QS++ +L+Q 
Sbjct: 184  DHHSKDT---TLIHQIFGGYWRSQIKCLHCHGISDTFDPYLDIALDIQAAQSVQQALEQL 240

Query: 1686 VRGEVLEGSNAYYCEKCKEKRITVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKYDEQIR 1745
            V+ E L G NAY+C  C ++    K   + +   VL++ L RF          K  + ++
Sbjct: 241  VKPEELNGENAYHCGVCLQRAPASKTLTLHTSAKVLILVLKRF----SDVTGNKIAKNVQ 296

Query: 1746 FPWMLNMEPYTVSGMARQDSSSEVGENGRSVDQGGGGSPRKKVALTENYELVGVIVHSG- 1804
            +P  L+M+PY    M++Q++   V                        Y L  V+VH+G 
Sbjct: 297  YPECLDMQPY----MSQQNTGPLV------------------------YVLYAVLVHAGW 328

Query: 1805 QAHAGHYYSFIKDRRGCGKGKWYKFNDTVI 1834
              H GHY+S++K +    +G+WYK +D  +
Sbjct: 329  SCHNGHYFSYVKAQ----EGQWYKMDDAEV 354


>gi|169217654 PREDICTED: similar to deubiquitinating enzyme DUB1 [Homo
            sapiens]
          Length = 530

 Score = 90.5 bits (223), Expect = 2e-17
 Identities = 81/327 (24%), Positives = 145/327 (44%), Gaps = 49/327 (14%)

Query: 1517 LPPVDSRSSSGFVGLRNGGATCYMNAVFQQLYMQPGLPESLLSVDDDTDNPDDSVFYQVQ 1576
            LP    R ++   GL+N G TCY+NA  Q L   P L   +LS  + +          + 
Sbjct: 68   LPLSSRRPAAVGAGLQNMGNTCYVNASLQCLTYTPPLANYMLS-REHSQTCHRHKGCMLC 126

Query: 1577 SLFGHLMESKLQYYVPENFWKIFKMWNKELYVREQQDAYEFFTSLIDQMDEYLKKMGR-- 1634
            ++  H+  +    + P +  +  +      +  +Q+DA+EF    +D M +      +  
Sbjct: 127  TMQAHITRA---LHNPGHVIQPSQALAAGFHRGKQEDAHEFLMFTVDAMKKACLPGHKQA 183

Query: 1635 DQIFKNT------FQGIYSDQKICKDCPHRYEREEAFMALNLGVTSCQSLEISLDQFVRG 1688
            D   K+T      F G +  Q  C  C    +  + ++ + L + + QS++ +L+Q V+ 
Sbjct: 184  DHHSKDTTLIHQIFGGYWRSQIKCLHCHGISDTFDPYLDIALDIQAAQSVQQALEQLVKP 243

Query: 1689 EVLEGSNAYYCEKCKEKRITVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKYDEQIRFPW 1748
            E L G NAY+C  C ++    K   + +   VL++ L RF          K  + +++P 
Sbjct: 244  EELNGENAYHCGVCLQRAPASKTLTLHTSAKVLILVLKRF----SDVTGNKIAKNVQYPE 299

Query: 1749 MLNMEPYTVSGMARQDSSSEVGENGRSVDQGGGGSPRKKVALTENYELVGVIVHSG-QAH 1807
             L+M+PY    M++Q++   V                        Y L  V+VH+G   H
Sbjct: 300  CLDMQPY----MSQQNTGPLV------------------------YVLYAVLVHAGWSCH 331

Query: 1808 AGHYYSFIKDRRGCGKGKWYKFNDTVI 1834
             GHY+S++K +    +G+WYK +D  +
Sbjct: 332  NGHYFSYVKAQ----EGQWYKMDDAEV 354


>gi|239742282 PREDICTED: hypothetical protein XP_002342474 [Homo
            sapiens]
          Length = 530

 Score = 90.5 bits (223), Expect = 2e-17
 Identities = 81/327 (24%), Positives = 145/327 (44%), Gaps = 49/327 (14%)

Query: 1517 LPPVDSRSSSGFVGLRNGGATCYMNAVFQQLYMQPGLPESLLSVDDDTDNPDDSVFYQVQ 1576
            LP    R ++   GL+N G TCY+NA  Q L   P L   +LS  + +          + 
Sbjct: 68   LPLSSRRPAAVGAGLQNMGNTCYVNASLQCLTYTPPLANYMLS-REHSQTCHRHKGCMLC 126

Query: 1577 SLFGHLMESKLQYYVPENFWKIFKMWNKELYVREQQDAYEFFTSLIDQMDEYLKKMGR-- 1634
            ++  H+  +    + P +  +  +      +  +Q+DA+EF    +D M +      +  
Sbjct: 127  TMQAHITRA---LHNPGHVIQPSQALAAGFHRGKQEDAHEFLMFTVDAMKKACLPGHKQV 183

Query: 1635 DQIFKNT------FQGIYSDQKICKDCPHRYEREEAFMALNLGVTSCQSLEISLDQFVRG 1688
            D   K+T      F G +  Q  C  C    +  + ++ + L + + QS++ +L+Q V+ 
Sbjct: 184  DHPSKDTTLIHQIFGGYWRSQIKCLHCHGISDTFDPYLDIALDIQAAQSVQQALEQLVKP 243

Query: 1689 EVLEGSNAYYCEKCKEKRITVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKYDEQIRFPW 1748
            E L G NAY+C  C ++    K   + +   VL++ L RF          K  + +++P 
Sbjct: 244  EELNGENAYHCGVCLQRAPASKTLTLHTSAKVLILVLKRF----SDVTGNKIAKNVQYPE 299

Query: 1749 MLNMEPYTVSGMARQDSSSEVGENGRSVDQGGGGSPRKKVALTENYELVGVIVHSG-QAH 1807
             L+M+PY    M++Q++   V                        Y L  V+VH+G   H
Sbjct: 300  CLDMQPY----MSQQNTGPLV------------------------YVLYAVLVHAGWSCH 331

Query: 1808 AGHYYSFIKDRRGCGKGKWYKFNDTVI 1834
             GHY+S++K +    +G+WYK +D  +
Sbjct: 332  NGHYFSYVKAQ----EGQWYKMDDAEV 354


>gi|157785653 ubiquitin specific peptidase 17 [Homo sapiens]
          Length = 530

 Score = 90.1 bits (222), Expect = 2e-17
 Identities = 79/330 (23%), Positives = 144/330 (43%), Gaps = 55/330 (16%)

Query: 1517 LPPVDSRSSSGFVGLRNGGATCYMNAVFQQLYMQPGLPESLLSVDDDTDNPDDSVFYQVQ 1576
            LP    R ++   GL+N G TCY+NA  + L   P L   +LS  + +          + 
Sbjct: 68   LPLSSRRPAAVGAGLQNMGNTCYVNASLEWLTYTPPLANYMLS-REHSQTCHRHKGCMLC 126

Query: 1577 SLFGHLMESKLQYYVPENFWKIFKMWNKELYVREQQDAYEFFTSLID-----------QM 1625
            ++  H+  +    + P +  +  +      +  +Q+DA+EF    +D           Q+
Sbjct: 127  TMQAHITRA---LHNPGHVIQPSQALAAGFHRGKQEDAHEFLMFTVDAMKKACLPGHKQV 183

Query: 1626 DEYLKKMGRDQIFKNTFQGIYSDQKICKDCPHRYEREEAFMALNLGVTSCQSLEISLDQF 1685
            D + K      +    F G +  Q  C  C    +  + ++ + L + + QS++ +L+Q 
Sbjct: 184  DHHSKDT---TLIHQIFGGYWRSQIKCLHCHGISDTFDPYLDIALDIQAAQSVQQALEQL 240

Query: 1686 VRGEVLEGSNAYYCEKCKEKRITVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKYDEQIR 1745
            V+ E L G NAY+C  C ++    K   + +   VL++ L RF          K  + ++
Sbjct: 241  VKPEELNGENAYHCGVCLQRAPASKTLTLHTSAKVLILVLKRF----SDVTGNKIAKNVQ 296

Query: 1746 FPWMLNMEPYTVSGMARQDSSSEVGENGRSVDQGGGGSPRKKVALTENYELVGVIVHSG- 1804
            +P  L+M+PY    M++Q++   V                        Y L  V+VH+G 
Sbjct: 297  YPECLDMQPY----MSQQNTGPLV------------------------YVLYAVLVHAGW 328

Query: 1805 QAHAGHYYSFIKDRRGCGKGKWYKFNDTVI 1834
              H GHY+S++K +    +G+WYK +D  +
Sbjct: 329  SCHNGHYFSYVKAQ----EGQWYKMDDAEV 354


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.133    0.387 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 88,431,910
Number of Sequences: 37866
Number of extensions: 3868856
Number of successful extensions: 15413
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 115
Number of HSP's successfully gapped in prelim test: 32
Number of HSP's that attempted gapping in prelim test: 14049
Number of HSP's gapped (non-prelim): 876
length of query: 2460
length of database: 18,247,518
effective HSP length: 119
effective length of query: 2341
effective length of database: 13,741,464
effective search space: 32168767224
effective search space used: 32168767224
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 71 (32.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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