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Search of human proteins with 148839316
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|148839316 NIMA-related kinase 4 [Homo sapiens]
(841 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|148839316 NIMA-related kinase 4 [Homo sapiens] 1667 0.0
gi|41872673 NIMA-related kinase 1 [Homo sapiens] 296 7e-80
gi|23510391 NIMA-related kinase 3 isoform a [Homo sapiens] 257 4e-68
gi|23510393 NIMA-related kinase 3 isoform a [Homo sapiens] 257 4e-68
gi|225735561 NIMA-related kinase 3 isoform b [Homo sapiens] 255 1e-67
gi|83627721 NIMA-related kinase 5 [Homo sapiens] 253 5e-67
gi|41281753 NIMA-related kinase 11 isoform 2 [Homo sapiens] 229 8e-60
gi|225637562 NIMA-related kinase 11 isoform 3 [Homo sapiens] 229 8e-60
gi|225637560 NIMA-related kinase 11 isoform 1 [Homo sapiens] 229 8e-60
gi|30039692 NIMA-related kinase 8 [Homo sapiens] 216 7e-56
gi|222136641 NIMA-related kinase 9 [Homo sapiens] 216 9e-56
gi|4505373 NIMA-related kinase 2 [Homo sapiens] 192 8e-49
gi|19424132 NIMA-related kinase 7 [Homo sapiens] 189 9e-48
gi|222418622 NIMA-related kinase 6 isoform 1 [Homo sapiens] 182 1e-45
gi|19923407 NIMA-related kinase 6 isoform 2 [Homo sapiens] 182 1e-45
gi|217330634 serine/threonine kinase 36 [Homo sapiens] 150 6e-36
gi|68077164 Yeast Sps1/Ste20-related kinase 4 isoform 1 [Homo sa... 146 9e-35
gi|63998898 Yeast Sps1/Ste20-related kinase 4 isoform 2 [Homo sa... 146 9e-35
gi|93004081 polo-like kinase 2 [Homo sapiens] 143 6e-34
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens] 140 5e-33
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens] 140 5e-33
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens] 140 5e-33
gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens] 140 5e-33
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 139 1e-32
gi|208431827 eukaryotic translation initiation factor 2-alpha ki... 138 2e-32
gi|4506103 eukaryotic translation initiation factor 2-alpha kina... 138 2e-32
gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 136 7e-32
gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 136 7e-32
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 135 1e-31
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 135 1e-31
>gi|148839316 NIMA-related kinase 4 [Homo sapiens]
Length = 841
Score = 1667 bits (4317), Expect = 0.0
Identities = 841/841 (100%), Positives = 841/841 (100%)
Query: 1 MPLAAYCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQL 60
MPLAAYCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQL
Sbjct: 1 MPLAAYCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQL 60
Query: 61 KHPNIVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQ 120
KHPNIVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQ
Sbjct: 61 KHPNIVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQ 120
Query: 121 YLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSN 180
YLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSN
Sbjct: 121 YLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSN 180
Query: 181 KPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRT 240
KPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRT
Sbjct: 181 KPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRT 240
Query: 241 MLSKRPEERPSVRSILRQPYIKRQISFFLEATKIKTSKNNIKNGDSQSKPFATVVSGEAE 300
MLSKRPEERPSVRSILRQPYIKRQISFFLEATKIKTSKNNIKNGDSQSKPFATVVSGEAE
Sbjct: 241 MLSKRPEERPSVRSILRQPYIKRQISFFLEATKIKTSKNNIKNGDSQSKPFATVVSGEAE 300
Query: 301 SNHEVIHPQPLSSEGSQTYIMGEGKCLSQEKPRASGLLKSPASLKAHTCKQDLSNTTELA 360
SNHEVIHPQPLSSEGSQTYIMGEGKCLSQEKPRASGLLKSPASLKAHTCKQDLSNTTELA
Sbjct: 301 SNHEVIHPQPLSSEGSQTYIMGEGKCLSQEKPRASGLLKSPASLKAHTCKQDLSNTTELA 360
Query: 361 TISSVNIDILPAKGRDSVSDGFVQENQPRYLDASNELGGICSISQVEEEMLQDNTKSSAQ 420
TISSVNIDILPAKGRDSVSDGFVQENQPRYLDASNELGGICSISQVEEEMLQDNTKSSAQ
Sbjct: 361 TISSVNIDILPAKGRDSVSDGFVQENQPRYLDASNELGGICSISQVEEEMLQDNTKSSAQ 420
Query: 421 PENLIPMWSSDIVTGEKNEPVKPLQPLIKEQKPKDQSLALSPKLECSGTILAHSNLRLLG 480
PENLIPMWSSDIVTGEKNEPVKPLQPLIKEQKPKDQSLALSPKLECSGTILAHSNLRLLG
Sbjct: 421 PENLIPMWSSDIVTGEKNEPVKPLQPLIKEQKPKDQSLALSPKLECSGTILAHSNLRLLG 480
Query: 481 SSDSPASASRVAGITGVCHHAQDQVAGECIIEKQGRIHPDLQPHNSGSEPSLSRQRRQKR 540
SSDSPASASRVAGITGVCHHAQDQVAGECIIEKQGRIHPDLQPHNSGSEPSLSRQRRQKR
Sbjct: 481 SSDSPASASRVAGITGVCHHAQDQVAGECIIEKQGRIHPDLQPHNSGSEPSLSRQRRQKR 540
Query: 541 REQTEHRGEKRQVRRDLFAFQESPPRFLPSHPIVGKVDVTSTQKEAENQRRVVTGSVSSS 600
REQTEHRGEKRQVRRDLFAFQESPPRFLPSHPIVGKVDVTSTQKEAENQRRVVTGSVSSS
Sbjct: 541 REQTEHRGEKRQVRRDLFAFQESPPRFLPSHPIVGKVDVTSTQKEAENQRRVVTGSVSSS 600
Query: 601 RSSEMSSSKDRPLSARERRRLKQSQEEMSSSGPSVRKASLSVAGPGKPQEEDQPLPARRL 660
RSSEMSSSKDRPLSARERRRLKQSQEEMSSSGPSVRKASLSVAGPGKPQEEDQPLPARRL
Sbjct: 601 RSSEMSSSKDRPLSARERRRLKQSQEEMSSSGPSVRKASLSVAGPGKPQEEDQPLPARRL 660
Query: 661 SSDCSVTQERKQIHCLSEDELSSSTSSTDKSDGDYGEGKGQTNEINALVQLMTQTLKLDS 720
SSDCSVTQERKQIHCLSEDELSSSTSSTDKSDGDYGEGKGQTNEINALVQLMTQTLKLDS
Sbjct: 661 SSDCSVTQERKQIHCLSEDELSSSTSSTDKSDGDYGEGKGQTNEINALVQLMTQTLKLDS 720
Query: 721 KESCEDVPVANPVSEFKLHRKYRDTLILHGKVAEEAEEIHFKELPSAIMPGSEKIRRLVE 780
KESCEDVPVANPVSEFKLHRKYRDTLILHGKVAEEAEEIHFKELPSAIMPGSEKIRRLVE
Sbjct: 721 KESCEDVPVANPVSEFKLHRKYRDTLILHGKVAEEAEEIHFKELPSAIMPGSEKIRRLVE 780
Query: 781 VLRTDVIRGLGVQLLEQVYDLLEEEDEFDREVRLREHMGEKYTTYSVKARQLKFFEENMN 840
VLRTDVIRGLGVQLLEQVYDLLEEEDEFDREVRLREHMGEKYTTYSVKARQLKFFEENMN
Sbjct: 781 VLRTDVIRGLGVQLLEQVYDLLEEEDEFDREVRLREHMGEKYTTYSVKARQLKFFEENMN 840
Query: 841 F 841
F
Sbjct: 841 F 841
>gi|41872673 NIMA-related kinase 1 [Homo sapiens]
Length = 1258
Score = 296 bits (757), Expect = 7e-80
Identities = 135/264 (51%), Positives = 195/264 (73%), Gaps = 1/264 (0%)
Query: 6 YCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNI 65
Y L+ +G+GS+G+ LVK DG+QYVIK++N+ SS+ER + +E +L+ +KHPNI
Sbjct: 4 YVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKHPNI 63
Query: 66 VTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQYLHEK 125
V Y+ES+E +G LYIVM +CEGGDL++++ QKG L E+Q+++WFVQI +AL+++H++
Sbjct: 64 VQYRESFEE-NGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVHDR 122
Query: 126 HILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSNKPYNY 185
ILHRD+K+QN+FLT+ +++GD GIARVL + ++A T IGTPYY+SPE+ NKPYN
Sbjct: 123 KILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNN 182
Query: 186 KSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRTMLSKR 245
KSD+WALGC +YE+ TLKHAF A M +LV +II G PP+ YS +L L+ + +
Sbjct: 183 KSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFKRN 242
Query: 246 PEERPSVRSILRQPYIKRQISFFL 269
P +RPSV SIL + +I ++I FL
Sbjct: 243 PRDRPSVNSILEKGFIAKRIEKFL 266
>gi|23510391 NIMA-related kinase 3 isoform a [Homo sapiens]
Length = 506
Score = 257 bits (656), Expect = 4e-68
Identities = 121/310 (39%), Positives = 193/310 (62%), Gaps = 13/310 (4%)
Query: 6 YCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNI 65
Y LR++G+GS+G LV+H + + +K++ L + S + + +EA LL+++KHPNI
Sbjct: 4 YMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNS-RKEAVLLAKMKHPNI 62
Query: 66 VTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQYLHEK 125
V +KES+E +G LYIVM +C+GGDL +K+K+QKG+L PE+ ++ WF Q+ + + ++H+K
Sbjct: 63 VAFKESFEA-EGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHKK 121
Query: 126 HILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSNKPYNY 185
+LHRD+K++N+FLT+ +K+GD G AR+L N A T +GTPYY+ PE++ N PYN
Sbjct: 122 RVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYNN 181
Query: 186 KSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRTMLSKR 245
KSD+W+LGC +YE+ TLKH F A +L+ ++ +G + P+P YS EL L++ M +
Sbjct: 182 KSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFKRN 241
Query: 246 PEERPSVRSILRQPYIKRQISFFLE-----------ATKIKTSKNNIKNGDSQSKPFATV 294
P RPS ++L + + R + L +IK SK+N +
Sbjct: 242 PSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEIKNSKHNTPRKKTNPSRIRIA 301
Query: 295 VSGEAESNHE 304
+ EA + E
Sbjct: 302 LGNEASTVQE 311
>gi|23510393 NIMA-related kinase 3 isoform a [Homo sapiens]
Length = 506
Score = 257 bits (656), Expect = 4e-68
Identities = 121/310 (39%), Positives = 193/310 (62%), Gaps = 13/310 (4%)
Query: 6 YCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNI 65
Y LR++G+GS+G LV+H + + +K++ L + S + + +EA LL+++KHPNI
Sbjct: 4 YMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNS-RKEAVLLAKMKHPNI 62
Query: 66 VTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQYLHEK 125
V +KES+E +G LYIVM +C+GGDL +K+K+QKG+L PE+ ++ WF Q+ + + ++H+K
Sbjct: 63 VAFKESFEA-EGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHKK 121
Query: 126 HILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSNKPYNY 185
+LHRD+K++N+FLT+ +K+GD G AR+L N A T +GTPYY+ PE++ N PYN
Sbjct: 122 RVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYNN 181
Query: 186 KSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRTMLSKR 245
KSD+W+LGC +YE+ TLKH F A +L+ ++ +G + P+P YS EL L++ M +
Sbjct: 182 KSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFKRN 241
Query: 246 PEERPSVRSILRQPYIKRQISFFLE-----------ATKIKTSKNNIKNGDSQSKPFATV 294
P RPS ++L + + R + L +IK SK+N +
Sbjct: 242 PSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEIKNSKHNTPRKKTNPSRIRIA 301
Query: 295 VSGEAESNHE 304
+ EA + E
Sbjct: 302 LGNEASTVQE 311
>gi|225735561 NIMA-related kinase 3 isoform b [Homo sapiens]
Length = 489
Score = 255 bits (652), Expect = 1e-67
Identities = 112/260 (43%), Positives = 179/260 (68%), Gaps = 2/260 (0%)
Query: 6 YCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNI 65
Y LR++G+GS+G LV+H + + +K++ L + S + + +EA LL+++KHPNI
Sbjct: 4 YMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNS-RKEAVLLAKMKHPNI 62
Query: 66 VTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQYLHEK 125
V +KES+E +G LYIVM +C+GGDL +K+K+QKG+L PE+ ++ WF Q+ + + ++H+K
Sbjct: 63 VAFKESFEA-EGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHKK 121
Query: 126 HILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSNKPYNY 185
+LHRD+K++N+FLT+ +K+GD G AR+L N A T +GTPYY+ PE++ N PYN
Sbjct: 122 RVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYNN 181
Query: 186 KSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRTMLSKR 245
KSD+W+LGC +YE+ TLKH F A +L+ ++ +G + P+P YS EL L++ M +
Sbjct: 182 KSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFKRN 241
Query: 246 PEERPSVRSILRQPYIKRQI 265
P RPS ++L + + R +
Sbjct: 242 PSHRPSATTLLSRGIVARLV 261
>gi|83627721 NIMA-related kinase 5 [Homo sapiens]
Length = 708
Score = 253 bits (646), Expect = 5e-67
Identities = 114/265 (43%), Positives = 183/265 (69%), Gaps = 2/265 (0%)
Query: 6 YCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNI 65
Y ++ +G+G++G+ L K + D K VIK++N +E+ A+++E LL ++KHPNI
Sbjct: 4 YDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEINFEKMPIQEKEASKKEVILLEKMKHPNI 63
Query: 66 VTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQYLHEK 125
V + S++ +G L+IVM +C+GGDL +++ Q+G L E+Q++ WFVQI++ L+++H++
Sbjct: 64 VAFFNSFQE-NGRLFIVMEYCDGGDLMKRINRQRGVLFSEDQILGWFVQISLGLKHIHDR 122
Query: 126 HILHRDLKTQNVFLTRTNII-KVGDLGIARVLENHCDMASTLIGTPYYMSPELFSNKPYN 184
ILHRD+K QN+FL++ ++ K+GD GIARVL N ++A T IGTPYY+SPE+ NKPYN
Sbjct: 123 KILHRDIKAQNIFLSKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSPEICQNKPYN 182
Query: 185 YKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRTMLSK 244
K+D+W+LGC +YE+ TLKH F ++ LV +I + P+ +S EL LI +
Sbjct: 183 NKTDIWSLGCVLYELCTLKHPFEGNNLQQLVLKICQAHFAPISPGFSRELHSLISQLFQV 242
Query: 245 RPEERPSVRSILRQPYIKRQISFFL 269
P +RPS+ SIL++P+++ I +L
Sbjct: 243 SPRDRPSINSILKRPFLENLIPKYL 267
>gi|41281753 NIMA-related kinase 11 isoform 2 [Homo sapiens]
Length = 470
Score = 229 bits (584), Expect = 8e-60
Identities = 114/265 (43%), Positives = 173/265 (65%), Gaps = 7/265 (2%)
Query: 6 YCYLRVVGKGSYGEVTLV---KHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKH 62
Y + +G GS+G V LV K +R + V+K++++ + E A EAQLLS+L H
Sbjct: 29 YVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLDH 88
Query: 63 PNIVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQK--GQLLPENQVVEWFVQIAMALQ 120
P IV + S+ D I+ +CEG DL K++E K G++ PENQ++EWF+Q+ + +
Sbjct: 89 PAIVKFHASFVEQDNFC-IITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVD 147
Query: 121 YLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSN 180
Y+HE+ ILHRDLK++NVFL + N++K+GD G++R+L CD+A+TL GTP+YMSPE +
Sbjct: 148 YMHERRILHRDLKSKNVFL-KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKH 206
Query: 181 KPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRT 240
+ Y+ KSD+W+L C +YEM + HAF + S+V +I+EG P +P Y EL ++ +
Sbjct: 207 QGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMES 266
Query: 241 MLSKRPEERPSVRSILRQPYIKRQI 265
ML+K P RPS IL+ PY+ Q+
Sbjct: 267 MLNKNPSLRPSAIEILKIPYLDEQL 291
>gi|225637562 NIMA-related kinase 11 isoform 3 [Homo sapiens]
Length = 599
Score = 229 bits (584), Expect = 8e-60
Identities = 114/265 (43%), Positives = 173/265 (65%), Gaps = 7/265 (2%)
Query: 6 YCYLRVVGKGSYGEVTLV---KHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKH 62
Y + +G GS+G V LV K +R + V+K++++ + E A EAQLLS+L H
Sbjct: 29 YVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLDH 88
Query: 63 PNIVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQK--GQLLPENQVVEWFVQIAMALQ 120
P IV + S+ D I+ +CEG DL K++E K G++ PENQ++EWF+Q+ + +
Sbjct: 89 PAIVKFHASFVEQDNFC-IITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVD 147
Query: 121 YLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSN 180
Y+HE+ ILHRDLK++NVFL + N++K+GD G++R+L CD+A+TL GTP+YMSPE +
Sbjct: 148 YMHERRILHRDLKSKNVFL-KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKH 206
Query: 181 KPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRT 240
+ Y+ KSD+W+L C +YEM + HAF + S+V +I+EG P +P Y EL ++ +
Sbjct: 207 QGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMES 266
Query: 241 MLSKRPEERPSVRSILRQPYIKRQI 265
ML+K P RPS IL+ PY+ Q+
Sbjct: 267 MLNKNPSLRPSAIEILKIPYLDEQL 291
>gi|225637560 NIMA-related kinase 11 isoform 1 [Homo sapiens]
Length = 645
Score = 229 bits (584), Expect = 8e-60
Identities = 114/265 (43%), Positives = 173/265 (65%), Gaps = 7/265 (2%)
Query: 6 YCYLRVVGKGSYGEVTLV---KHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKH 62
Y + +G GS+G V LV K +R + V+K++++ + E A EAQLLS+L H
Sbjct: 29 YVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLDH 88
Query: 63 PNIVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQK--GQLLPENQVVEWFVQIAMALQ 120
P IV + S+ D I+ +CEG DL K++E K G++ PENQ++EWF+Q+ + +
Sbjct: 89 PAIVKFHASFVEQDNFC-IITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVD 147
Query: 121 YLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSN 180
Y+HE+ ILHRDLK++NVFL + N++K+GD G++R+L CD+A+TL GTP+YMSPE +
Sbjct: 148 YMHERRILHRDLKSKNVFL-KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKH 206
Query: 181 KPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRT 240
+ Y+ KSD+W+L C +YEM + HAF + S+V +I+EG P +P Y EL ++ +
Sbjct: 207 QGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMES 266
Query: 241 MLSKRPEERPSVRSILRQPYIKRQI 265
ML+K P RPS IL+ PY+ Q+
Sbjct: 267 MLNKNPSLRPSAIEILKIPYLDEQL 291
>gi|30039692 NIMA-related kinase 8 [Homo sapiens]
Length = 692
Score = 216 bits (550), Expect = 7e-56
Identities = 117/312 (37%), Positives = 188/312 (60%), Gaps = 6/312 (1%)
Query: 6 YCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNI 65
Y +RVVG+G++G V L + D K +IK++ + + ER+AA+ E Q+L L HPN+
Sbjct: 4 YERIRVVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLLNHPNV 63
Query: 66 VTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQYLHEK 125
+ Y E++ D L I M + GG L ++++ LL E ++ +FVQI +AL ++H
Sbjct: 64 IEYYENFLE-DKALMIAMEYAPGGTLAEFIQKRCNSLLEEETILHFFVQILLALHHVHTH 122
Query: 126 HILHRDLKTQNVFLTRTN-IIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSNKPYN 184
ILHRDLKTQN+ L + ++K+GD GI+++L + A T++GTP Y+SPEL KPYN
Sbjct: 123 LILHRDLKTQNILLDKHRMVVKIGDFGISKILSSK-SKAYTVVGTPCYISPELCEGKPYN 181
Query: 185 YKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRTMLSK 244
KSD+WALGC +YE+A+LK AF A ++ +LV +I+ G P+ YSPEL +L+ ++LS
Sbjct: 182 QKSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLVLSLLSL 241
Query: 245 RPEERPSVRSILRQPYIKR---QISFFLEATKIKTSKNNIKNGDSQSKPFATVVSGEAES 301
P +RP + I+ QP R + + + +++ ++ ++ ++ S+ + G
Sbjct: 242 EPAQRPPLSHIMAQPLCIRALLNLHTDVGSVRMRRAEKSVAPSNTGSRTTSVRCRGIPRG 301
Query: 302 NHEVIHPQPLSS 313
P PLSS
Sbjct: 302 PVRPAIPPPLSS 313
>gi|222136641 NIMA-related kinase 9 [Homo sapiens]
Length = 979
Score = 216 bits (549), Expect = 9e-56
Identities = 119/328 (36%), Positives = 184/328 (56%), Gaps = 21/328 (6%)
Query: 6 YCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNI 65
Y +RV+G+G++GE TL + D V K+++L S +ERR A E +L+ L+H NI
Sbjct: 52 YIPIRVLGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDALNEIVILALLQHDNI 111
Query: 66 VTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQYLHEK 125
+ Y + LL I + +C GG+LY K+ QK +L E VV + QI A+ +H+
Sbjct: 112 IAYYNHFMDNTTLL-IELEYCNGGNLYDKILRQKDKLFEEEMVVWYLFQIVSAVSCIHKA 170
Query: 126 HILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSNKPYNY 185
ILHRD+KT N+FLT+ N+IK+GD G+A+ L + MA TL+GTPYYMSPEL YN+
Sbjct: 171 GILHRDIKTLNIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNF 230
Query: 186 KSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEG--KLPPMPRDYSPELAELIRTMLS 243
KSD+WA+GC ++E+ TLK F+A + +L +I++G + YS EL +++ + L
Sbjct: 231 KSDIWAVGCVIFELLTLKRTFDATNPLNLCVKIVQGIRAMEVDSSQYSLELIQMVHSCLD 290
Query: 244 KRPEERPSVRSILRQPYI-KRQISFFLEATKIKTSKNNIKNGDSQSKPFATVVSGEAESN 302
+ PE+RP+ +L +P + KR+ + T + ++ P A V
Sbjct: 291 QDPEQRPTADELLDRPLLRKRRREMEEKVTLLNAPTKRPRSSTVTEAPIAVV-------- 342
Query: 303 HEVIHPQPLSSEGSQTYIMGEGKCLSQE 330
+S S+ Y+ G GK Q+
Sbjct: 343 ---------TSRTSEVYVWGGGKSTPQK 361
>gi|4505373 NIMA-related kinase 2 [Homo sapiens]
Length = 445
Score = 192 bits (489), Expect = 8e-49
Identities = 108/264 (40%), Positives = 149/264 (56%), Gaps = 8/264 (3%)
Query: 6 YCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNI 65
Y L +G GSYG ++ + DGK V K+L+ + + E++ E LL +LKHPNI
Sbjct: 8 YEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNI 67
Query: 66 VTYKESW-EGGDGLLYIVMGFCEGGDLYRKLKE--QKGQLLPENQVVEWFVQIAMALQYL 122
V Y + + + LYIVM +CEGGDL + + ++ Q L E V+ Q+ +AL+
Sbjct: 68 VRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKEC 127
Query: 123 HEKH-----ILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPEL 177
H + +LHRDLK NVFL +K+GD G+AR+L + A T +GTPYYMSPE
Sbjct: 128 HRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSPEQ 187
Query: 178 FSNKPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAEL 237
+ YN KSD+W+LGC +YE+ L F A L +I EGK +P YS EL E+
Sbjct: 188 MNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEI 247
Query: 238 IRTMLSKRPEERPSVRSILRQPYI 261
I ML+ + RPSV IL P I
Sbjct: 248 ITRMLNLKDYHRPSVEEILENPLI 271
Score = 31.2 bits (69), Expect = 4.2
Identities = 36/158 (22%), Positives = 69/158 (43%), Gaps = 13/158 (8%)
Query: 571 HPIVGKVDVTSTQKEAENQRRVVTGSVSSSRSSE-MSSSKDRPLSARERRRLKQSQEEMS 629
+P++ + ++ E + R + S SS +S K + + +ER R +++EE
Sbjct: 268 NPLIADLVADEQRRNLERRGRQLGEPEKSQDSSPVLSELKLKEIQLQERERALKAREERL 327
Query: 630 SSGPSVRKASLSVAGPGKPQEEDQPLPARRLSSDCSVTQERKQIHCLSEDELSSSTSSTD 689
++ L V + ED+ A L + S+ +ERK + S EL + SS
Sbjct: 328 EQ----KEQELCVR---ERLAEDKLARAENLLKNYSLLKERKFLSLASNPELLNLPSSVI 380
Query: 690 KSDGDYGEGKGQTNEINALVQLMTQTLKLDSKESCEDV 727
K + G+ + N +++ +L SK C+D+
Sbjct: 381 KKKVHF-SGESKEN----IMRSENSESQLTSKSKCKDL 413
>gi|19424132 NIMA-related kinase 7 [Homo sapiens]
Length = 302
Score = 189 bits (480), Expect = 9e-48
Identities = 103/256 (40%), Positives = 152/256 (59%), Gaps = 7/256 (2%)
Query: 3 LAAYCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRA-AEQEAQLLSQLK 61
LA + + +G+G + EV DG +KK+ + + + RA +E LL QL
Sbjct: 31 LANFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLN 90
Query: 62 HPNIVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQ--LLPENQVVEWFVQIAMAL 119
HPN++ Y S+ D L IV+ + GDL R +K K Q L+PE V ++FVQ+ AL
Sbjct: 91 HPNVIKYYASFIE-DNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSAL 149
Query: 120 QYLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFS 179
+++H + ++HRD+K NVF+T T ++K+GDLG+ R + A +L+GTPYYMSPE
Sbjct: 150 EHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIH 209
Query: 180 NKPYNYKSDVWALGCCVYEMATLKHAFNAKDMN--SLVYRIIEGKLPPMPRD-YSPELAE 236
YN+KSD+W+LGC +YEMA L+ F MN SL +I + PP+P D YS EL +
Sbjct: 210 ENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQ 269
Query: 237 LIRTMLSKRPEERPSV 252
L+ ++ PE+RP V
Sbjct: 270 LVNMCINPDPEKRPDV 285
>gi|222418622 NIMA-related kinase 6 isoform 1 [Homo sapiens]
Length = 347
Score = 182 bits (461), Expect = 1e-45
Identities = 100/276 (36%), Positives = 161/276 (58%), Gaps = 10/276 (3%)
Query: 3 LAAYCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNL-RNASSRERRAAEQEAQLLSQLK 61
LA + + +G+G + EV D K +KK+ + ++ R+ +E LL QL
Sbjct: 76 LADFQIEKKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLN 135
Query: 62 HPNIVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQ--LLPENQVVEWFVQIAMAL 119
HPNI+ Y +S+ D L IV+ + GDL + +K K Q L+PE V ++FVQ+ A+
Sbjct: 136 HPNIIKYLDSFIE-DNELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAV 194
Query: 120 QYLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFS 179
+++H + ++HRD+K NVF+T T ++K+GDLG+ R + A +L+GTPYYMSPE
Sbjct: 195 EHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSETTAAHSLVGTPYYMSPERIH 254
Query: 180 NKPYNYKSDVWALGCCVYEMATLKHAFNAKDMN--SLVYRIIEGKLPPMPRD-YSPELAE 236
YN+KSD+W+LGC +YEMA L+ F MN SL +I + PP+P + YS +L E
Sbjct: 255 ENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCDYPPLPGEHYSEKLRE 314
Query: 237 LIRTMLSKRPEERPSVRSILRQPYIKRQISFFLEAT 272
L+ + P +RP + + + + +Q+ ++ +T
Sbjct: 315 LVSMCICPDPHQRPDIGYVHQ---VAKQMHIWMSST 347
>gi|19923407 NIMA-related kinase 6 isoform 2 [Homo sapiens]
Length = 313
Score = 182 bits (461), Expect = 1e-45
Identities = 100/276 (36%), Positives = 161/276 (58%), Gaps = 10/276 (3%)
Query: 3 LAAYCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNL-RNASSRERRAAEQEAQLLSQLK 61
LA + + +G+G + EV D K +KK+ + ++ R+ +E LL QL
Sbjct: 42 LADFQIEKKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLN 101
Query: 62 HPNIVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQ--LLPENQVVEWFVQIAMAL 119
HPNI+ Y +S+ D L IV+ + GDL + +K K Q L+PE V ++FVQ+ A+
Sbjct: 102 HPNIIKYLDSFIE-DNELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAV 160
Query: 120 QYLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFS 179
+++H + ++HRD+K NVF+T T ++K+GDLG+ R + A +L+GTPYYMSPE
Sbjct: 161 EHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSETTAAHSLVGTPYYMSPERIH 220
Query: 180 NKPYNYKSDVWALGCCVYEMATLKHAFNAKDMN--SLVYRIIEGKLPPMPRD-YSPELAE 236
YN+KSD+W+LGC +YEMA L+ F MN SL +I + PP+P + YS +L E
Sbjct: 221 ENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCDYPPLPGEHYSEKLRE 280
Query: 237 LIRTMLSKRPEERPSVRSILRQPYIKRQISFFLEAT 272
L+ + P +RP + + + + +Q+ ++ +T
Sbjct: 281 LVSMCICPDPHQRPDIGYVHQ---VAKQMHIWMSST 313
>gi|217330634 serine/threonine kinase 36 [Homo sapiens]
Length = 1315
Score = 150 bits (378), Expect = 6e-36
Identities = 89/265 (33%), Positives = 148/265 (55%), Gaps = 5/265 (1%)
Query: 6 YCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNI 65
Y L ++G+GS+G V + + + +K + S +E R ++E +++ L+HPNI
Sbjct: 4 YHVLEMIGEGSFGRVYKGRRKYSAQVVALKFIPKLGRSEKELRNLQREIEIMRGLRHPNI 63
Query: 66 VTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQYLHEK 125
V +S+E D + +V + EG +L++ L E G+L PE+QV Q+ AL YLH
Sbjct: 64 VHMLDSFET-DKEVVVVTDYAEG-ELFQIL-EDDGKL-PEDQVQAIAAQLVSALYYLHSH 119
Query: 126 HILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSNKPYNY 185
ILHRD+K QN+ L + IK+ D G AR + + + +++ GTP YMSPEL +PY++
Sbjct: 120 RILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTSIKGTPLYMSPELVEERPYDH 179
Query: 186 KSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRTMLSKR 245
+D+W++GC +YE+A F A + LV I++ + P SP ++ +L+K
Sbjct: 180 TADLWSVGCILYELAVGTPPFYATSIFQLVSLILKDPV-RWPSTISPCFKNFLQGLLTKD 238
Query: 246 PEERPSVRSILRQPYIKRQISFFLE 270
P +R S +L P+I ++ E
Sbjct: 239 PRQRLSWPDLLYHPFIAGHVTIITE 263
>gi|68077164 Yeast Sps1/Ste20-related kinase 4 isoform 1 [Homo
sapiens]
Length = 1328
Score = 146 bits (368), Expect = 9e-35
Identities = 91/265 (34%), Positives = 142/265 (53%), Gaps = 16/265 (6%)
Query: 11 VVGKGSYGEVTLVKHRRDGKQYVIKKLNL----RNASSRERRAAEQEAQLLSQLKHPNIV 66
++GKG+YG V G+ +K++ L + A+ +E R ++E LL LKH NIV
Sbjct: 1066 ILGKGAYGTV-YCGLTSQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIV 1124
Query: 67 TYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQYLHEKH 126
Y + + + I M F GG + + + LPE ++ QI + YLHE
Sbjct: 1125 AYLGTCLQ-ENTVSIFMEFVPGGSISSIIN--RFGPLPEMVFCKYTKQILQGVAYLHENC 1181
Query: 127 ILHRDLKTQNVFLTRTNIIKVGDLGIARVLE------NHCDMASTLIGTPYYMSPELFSN 180
++HRD+K NV L T IIK+ D G AR L H DM ++ GTPY+M+PE+ +
Sbjct: 1182 VVHRDIKGNNVMLMPTGIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMAPEVINE 1241
Query: 181 KPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRI--IEGKLPPMPRDYSPELAELI 238
Y KSD+W++GC V+EMAT K + D + ++ I G +PP+P +S A+ +
Sbjct: 1242 SGYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPPLPDHFSENAADFV 1301
Query: 239 RTMLSKRPEERPSVRSILRQPYIKR 263
R L++ ERPS +L+ +++R
Sbjct: 1302 RMCLTRDQHERPSALQLLKHSFLER 1326
>gi|63998898 Yeast Sps1/Ste20-related kinase 4 isoform 2 [Homo
sapiens]
Length = 510
Score = 146 bits (368), Expect = 9e-35
Identities = 91/265 (34%), Positives = 142/265 (53%), Gaps = 16/265 (6%)
Query: 11 VVGKGSYGEVTLVKHRRDGKQYVIKKLNL----RNASSRERRAAEQEAQLLSQLKHPNIV 66
++GKG+YG V G+ +K++ L + A+ +E R ++E LL LKH NIV
Sbjct: 248 ILGKGAYGTV-YCGLTSQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIV 306
Query: 67 TYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQYLHEKH 126
Y + + + I M F GG + + + LPE ++ QI + YLHE
Sbjct: 307 AYLGTCLQ-ENTVSIFMEFVPGGSISSIIN--RFGPLPEMVFCKYTKQILQGVAYLHENC 363
Query: 127 ILHRDLKTQNVFLTRTNIIKVGDLGIARVLE------NHCDMASTLIGTPYYMSPELFSN 180
++HRD+K NV L T IIK+ D G AR L H DM ++ GTPY+M+PE+ +
Sbjct: 364 VVHRDIKGNNVMLMPTGIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMAPEVINE 423
Query: 181 KPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRI--IEGKLPPMPRDYSPELAELI 238
Y KSD+W++GC V+EMAT K + D + ++ I G +PP+P +S A+ +
Sbjct: 424 SGYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPPLPDHFSENAADFV 483
Query: 239 RTMLSKRPEERPSVRSILRQPYIKR 263
R L++ ERPS +L+ +++R
Sbjct: 484 RMCLTRDQHERPSALQLLKHSFLER 508
>gi|93004081 polo-like kinase 2 [Homo sapiens]
Length = 685
Score = 143 bits (361), Expect = 6e-34
Identities = 87/256 (33%), Positives = 135/256 (52%), Gaps = 5/256 (1%)
Query: 6 YCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKL-NLRNASSRERRAAEQEAQLLSQLKHPN 64
YC +V+GKG + + + + K Y K + + R A +R ++E +L L H +
Sbjct: 82 YCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKH 141
Query: 65 IVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQYLHE 124
+V + +E + + YI++ +C + LK +K +L E +V + QI L+YLHE
Sbjct: 142 VVQFYHYFEDKENI-YILLEYCSRRSMAHILKARK--VLTEPEVRYYLRQIVSGLKYLHE 198
Query: 125 KHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSNKPYN 184
+ ILHRDLK N F+ +KVGD G+A LE T+ GTP Y+SPE+ + + +
Sbjct: 199 QEILHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHG 258
Query: 185 YKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRTMLSK 244
+SD+WALGC +Y M + F ++ YR I MP LI +MLSK
Sbjct: 259 CESDIWALGCVMYTMLLGRPPFETTNLKE-TYRCIREARYTMPSSLLAPAKHLIASMLSK 317
Query: 245 RPEERPSVRSILRQPY 260
PE+RPS+ I+R +
Sbjct: 318 NPEDRPSLDDIIRHDF 333
>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
Length = 1312
Score = 140 bits (353), Expect = 5e-33
Identities = 106/364 (29%), Positives = 174/364 (47%), Gaps = 28/364 (7%)
Query: 2 PLAAYCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLK 61
P + + VVG G+YG+V +H + G+ IK +++ + E +QE +L +
Sbjct: 21 PAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV---TEDEEEEIKQEINMLKKYS 77
Query: 62 HP-NIVTY-----KESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQI 115
H NI TY K+S G D L++VM FC G + +K KG L E+ + +I
Sbjct: 78 HHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREI 137
Query: 116 AMALQYLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSP 175
L +LH ++HRD+K QNV LT +K+ D G++ L+ +T IGTPY+M+P
Sbjct: 138 LRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
Query: 176 ELFS-----NKPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPP---MP 227
E+ + + Y+Y+SD+W+LG EMA + A DM+ + + + PP
Sbjct: 198 EVIACDENPDATYDYRSDIWSLGITAIEMA--EGAPPLCDMHPMRALFLIPRNPPPRLKS 255
Query: 228 RDYSPELAELIRTMLSKRPEERPSVRSILRQPYIK-----RQISFFLEATKIKTSKNNIK 282
+ +S + + I T L K RP +L+ P+I+ RQ+ L K ++ K
Sbjct: 256 KKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQL---KDHIDRSRKK 312
Query: 283 NGDSQSKPFATVVSGEAESNH-EVIHPQPLSSEGSQTYIMGEGKCLSQEKPRASGLLKSP 341
G+ + + S E + +H E P + + ++ + E L QE S LK
Sbjct: 313 RGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQENKSNSEALKQQ 372
Query: 342 ASLK 345
L+
Sbjct: 373 QQLQ 376
>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
Length = 1303
Score = 140 bits (353), Expect = 5e-33
Identities = 106/364 (29%), Positives = 174/364 (47%), Gaps = 28/364 (7%)
Query: 2 PLAAYCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLK 61
P + + VVG G+YG+V +H + G+ IK +++ + E +QE +L +
Sbjct: 21 PAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV---TEDEEEEIKQEINMLKKYS 77
Query: 62 HP-NIVTY-----KESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQI 115
H NI TY K+S G D L++VM FC G + +K KG L E+ + +I
Sbjct: 78 HHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREI 137
Query: 116 AMALQYLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSP 175
L +LH ++HRD+K QNV LT +K+ D G++ L+ +T IGTPY+M+P
Sbjct: 138 LRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
Query: 176 ELFS-----NKPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPP---MP 227
E+ + + Y+Y+SD+W+LG EMA + A DM+ + + + PP
Sbjct: 198 EVIACDENPDATYDYRSDIWSLGITAIEMA--EGAPPLCDMHPMRALFLIPRNPPPRLKS 255
Query: 228 RDYSPELAELIRTMLSKRPEERPSVRSILRQPYIK-----RQISFFLEATKIKTSKNNIK 282
+ +S + + I T L K RP +L+ P+I+ RQ+ L K ++ K
Sbjct: 256 KKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQL---KDHIDRSRKK 312
Query: 283 NGDSQSKPFATVVSGEAESNH-EVIHPQPLSSEGSQTYIMGEGKCLSQEKPRASGLLKSP 341
G+ + + S E + +H E P + + ++ + E L QE S LK
Sbjct: 313 RGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQENKSNSEALKQQ 372
Query: 342 ASLK 345
L+
Sbjct: 373 QQLQ 376
>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
Length = 1332
Score = 140 bits (353), Expect = 5e-33
Identities = 106/364 (29%), Positives = 174/364 (47%), Gaps = 28/364 (7%)
Query: 2 PLAAYCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLK 61
P + + VVG G+YG+V +H + G+ IK +++ + E +QE +L +
Sbjct: 21 PAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV---TEDEEEEIKQEINMLKKYS 77
Query: 62 HP-NIVTY-----KESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQI 115
H NI TY K+S G D L++VM FC G + +K KG L E+ + +I
Sbjct: 78 HHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREI 137
Query: 116 AMALQYLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSP 175
L +LH ++HRD+K QNV LT +K+ D G++ L+ +T IGTPY+M+P
Sbjct: 138 LRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
Query: 176 ELFS-----NKPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPP---MP 227
E+ + + Y+Y+SD+W+LG EMA + A DM+ + + + PP
Sbjct: 198 EVIACDENPDATYDYRSDIWSLGITAIEMA--EGAPPLCDMHPMRALFLIPRNPPPRLKS 255
Query: 228 RDYSPELAELIRTMLSKRPEERPSVRSILRQPYIK-----RQISFFLEATKIKTSKNNIK 282
+ +S + + I T L K RP +L+ P+I+ RQ+ L K ++ K
Sbjct: 256 KKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQL---KDHIDRSRKK 312
Query: 283 NGDSQSKPFATVVSGEAESNH-EVIHPQPLSSEGSQTYIMGEGKCLSQEKPRASGLLKSP 341
G+ + + S E + +H E P + + ++ + E L QE S LK
Sbjct: 313 RGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQENKSNSEALKQQ 372
Query: 342 ASLK 345
L+
Sbjct: 373 QQLQ 376
>gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]
Length = 1295
Score = 140 bits (353), Expect = 5e-33
Identities = 106/364 (29%), Positives = 174/364 (47%), Gaps = 28/364 (7%)
Query: 2 PLAAYCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLK 61
P + + VVG G+YG+V +H + G+ IK +++ + E +QE +L +
Sbjct: 21 PAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV---TEDEEEEIKQEINMLKKYS 77
Query: 62 HP-NIVTY-----KESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQI 115
H NI TY K+S G D L++VM FC G + +K KG L E+ + +I
Sbjct: 78 HHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREI 137
Query: 116 AMALQYLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSP 175
L +LH ++HRD+K QNV LT +K+ D G++ L+ +T IGTPY+M+P
Sbjct: 138 LRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
Query: 176 ELFS-----NKPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPP---MP 227
E+ + + Y+Y+SD+W+LG EMA + A DM+ + + + PP
Sbjct: 198 EVIACDENPDATYDYRSDIWSLGITAIEMA--EGAPPLCDMHPMRALFLIPRNPPPRLKS 255
Query: 228 RDYSPELAELIRTMLSKRPEERPSVRSILRQPYIK-----RQISFFLEATKIKTSKNNIK 282
+ +S + + I T L K RP +L+ P+I+ RQ+ L K ++ K
Sbjct: 256 KKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQL---KDHIDRSRKK 312
Query: 283 NGDSQSKPFATVVSGEAESNH-EVIHPQPLSSEGSQTYIMGEGKCLSQEKPRASGLLKSP 341
G+ + + S E + +H E P + + ++ + E L QE S LK
Sbjct: 313 RGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQENKSNSEALKQQ 372
Query: 342 ASLK 345
L+
Sbjct: 373 QQLQ 376
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 139 bits (349), Expect = 1e-32
Identities = 176/777 (22%), Positives = 308/777 (39%), Gaps = 105/777 (13%)
Query: 2 PLAAYCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLK 61
P + + VVG G+YG+V +H + G+ IK +++ + E + E +L +
Sbjct: 21 PAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV---TEDEEEEIKLEINMLKKYS 77
Query: 62 HP-NIVTY-----KESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQI 115
H NI TY K+S G D L++VM FC G + +K KG L E+ + +I
Sbjct: 78 HHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREI 137
Query: 116 AMALQYLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSP 175
L +LH H++HRD+K QNV LT +K+ D G++ L+ +T IGTPY+M+P
Sbjct: 138 LRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
Query: 176 ELFS-----NKPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPP---MP 227
E+ + + Y+Y+SD+W+ G EMA + A DM+ + + + PP
Sbjct: 198 EVIACDENPDATYDYRSDLWSCGITAIEMA--EGAPPLCDMHPMRALFLIPRNPPPRLKS 255
Query: 228 RDYSPELAELIRTMLSKRPEERPSVRSILRQPYIK-----RQISFFLEATKIKTSKNNIK 282
+ +S + I L K +RPS +L+ P+I+ RQ+ L+ +T K K
Sbjct: 256 KKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRK---K 312
Query: 283 NGDSQSKPFATVVSGEAESNHEVIHPQPLSSEGSQTYIMGEGKC------LSQEKPRASG 336
G+ + SG E EV P+ S + GE L QE S
Sbjct: 313 RGEKDETEYE--YSGSEEEEEEV--PEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSE 368
Query: 337 LLKSPASLKAHTCKQDLSNTTELATISSVNIDILPAKGRDSVSDGFVQENQPRYLDA--- 393
L+ L+ ++ +L I+ + R ++E Q R +A
Sbjct: 369 ALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRR------LEEQQRREREARRQ 422
Query: 394 ------SNELGGICSISQVEEEMLQDNTKSSAQPENLIPMWSSDIVTGEKNEPVKPL--- 444
E + ++E ++ + A+ E + + + E + L
Sbjct: 423 QEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVL 482
Query: 445 -QPLIKEQ----------KPKDQSLALSPKLECSG---------------------TILA 472
Q L++EQ P+ P+ E S +
Sbjct: 483 QQQLLQEQAMLLHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRAREVPVRT 542
Query: 473 HSNLRLLGSSDSPASASRVAGITGVCHHAQDQVAGECIIEKQGRIHP------DLQPHNS 526
S +L DSP S ++ + + E+ ++ P NS
Sbjct: 543 TSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNS 602
Query: 527 GSEP-------SLSRQRRQKRREQTEHRGEKRQVRRDLFAFQESPPRFLPSHPIVGKVDV 579
GS+P S S +R + R +++ + ++ F P P G+VD+
Sbjct: 603 GSQPGSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKP-AGEVDL 661
Query: 580 TSTQKEAENQRRVVTGSVSSSRSSEMSSSKDRPLSARERRRLKQSQEEMSSSGPSVRKAS 639
T+ KE R V + SSS++ + E ++Q + S+SGP +A+
Sbjct: 662 TALAKEL---RAVEDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAA 718
Query: 640 LSV-AGPGKPQEEDQPLPARRLSSDCSVTQERKQIHCLSEDELSSSTSSTDKSDGDY 695
S+ G+ + + + S+ ++T ++ + + + +SST KS +
Sbjct: 719 SSLNLSNGETESVKTMIVHDDVESEPAMTPSKEGTLIVRQTQSASSTLQKHKSSSSF 775
>gi|208431827 eukaryotic translation initiation factor 2-alpha
kinase 2 isoform a [Homo sapiens]
Length = 551
Score = 138 bits (348), Expect = 2e-32
Identities = 87/277 (31%), Positives = 141/277 (50%), Gaps = 40/277 (14%)
Query: 9 LRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNIVTY 68
+ ++G G +G+V KHR DGK YVIK++ N AE+E + L++L H NIV Y
Sbjct: 270 IELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEK------AEREVKALAKLDHVNIVHY 323
Query: 69 KESWEGGD----------------------------GLLYIVMGFCEGGDLYRKLKEQKG 100
W+G D L+I M FC+ G L + +++++G
Sbjct: 324 NGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRG 383
Query: 101 QLLPENQVVEWFVQIAMALQYLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHC 160
+ L + +E F QI + Y+H K ++HRDLK N+FL T +K+GD G+ L+N
Sbjct: 384 EKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDG 443
Query: 161 DMASTLIGTPYYMSPELFSNKPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIE 220
+ GT YMSPE S++ Y + D++ALG + E+ L A + + + +
Sbjct: 444 KRTRSK-GTLRYMSPEQISSQDYGKEVDLYALGLILAEL--LHVCDTAFETSKFFTDLRD 500
Query: 221 GKLPPMPRDYSPELAELIRTMLSKRPEERPSVRSILR 257
G + + + + L++ +LSK+PE+RP+ ILR
Sbjct: 501 GIISDI---FDKKEKTLLQKLLSKKPEDRPNTSEILR 534
>gi|4506103 eukaryotic translation initiation factor 2-alpha kinase
2 isoform a [Homo sapiens]
Length = 551
Score = 138 bits (348), Expect = 2e-32
Identities = 87/277 (31%), Positives = 141/277 (50%), Gaps = 40/277 (14%)
Query: 9 LRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNIVTY 68
+ ++G G +G+V KHR DGK YVIK++ N AE+E + L++L H NIV Y
Sbjct: 270 IELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEK------AEREVKALAKLDHVNIVHY 323
Query: 69 KESWEGGD----------------------------GLLYIVMGFCEGGDLYRKLKEQKG 100
W+G D L+I M FC+ G L + +++++G
Sbjct: 324 NGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRG 383
Query: 101 QLLPENQVVEWFVQIAMALQYLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHC 160
+ L + +E F QI + Y+H K ++HRDLK N+FL T +K+GD G+ L+N
Sbjct: 384 EKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDG 443
Query: 161 DMASTLIGTPYYMSPELFSNKPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIE 220
+ GT YMSPE S++ Y + D++ALG + E+ L A + + + +
Sbjct: 444 KRTRSK-GTLRYMSPEQISSQDYGKEVDLYALGLILAEL--LHVCDTAFETSKFFTDLRD 500
Query: 221 GKLPPMPRDYSPELAELIRTMLSKRPEERPSVRSILR 257
G + + + + L++ +LSK+PE+RP+ ILR
Sbjct: 501 GIISDI---FDKKEKTLLQKLLSKKPEDRPNTSEILR 534
>gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform b [Homo sapiens]
Length = 741
Score = 136 bits (343), Expect = 7e-32
Identities = 81/260 (31%), Positives = 140/260 (53%), Gaps = 12/260 (4%)
Query: 9 LRVVGKGSYGEVTLVKHRRD---GKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNI 65
L+V+G+GSYG+V LV+ + G+ Y +K L R+R ++ E +L+++ HP I
Sbjct: 70 LKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEVNHPFI 129
Query: 66 VTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQYLHEK 125
V +++ +G LY+++ F GGDL+ +L ++ + E V + ++A+AL +LH
Sbjct: 130 VKLHYAFQT-EGKLYLILDFLRGGDLFTRLSKEV--MFTEEDVKFYLAELALALDHLHSL 186
Query: 126 HILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSNKPYNY 185
I++RDLK +N+ L IK+ D G+++ +H A + GT YM+PE+ + + +
Sbjct: 187 GIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGHTQ 246
Query: 186 KSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRTMLSKR 245
+D W+ G ++EM T F KD + I++ KL MP+ S E L+R + +
Sbjct: 247 SADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKL-GMPQFLSGEAQSLLRALFKRN 305
Query: 246 PEER-----PSVRSILRQPY 260
P R V I R P+
Sbjct: 306 PCNRLGAGIDGVEEIKRHPF 325
Score = 91.7 bits (226), Expect = 3e-18
Identities = 66/261 (25%), Positives = 122/261 (46%), Gaps = 20/261 (7%)
Query: 12 VGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQL-KHPNIVTYKE 70
+G GSY H+ +Y +K ++ + +R +E ++L + +HPNI+T K+
Sbjct: 429 IGVGSYSVCKRCVHKATDTEYAVKIID------KSKRDPSEEIEILLRYGQHPNIITLKD 482
Query: 71 SWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQYLHEKHILHR 130
++ G +Y+VM GG+L ++ Q+ E + + I + YLH + ++HR
Sbjct: 483 VYDDGK-FVYLVMELMRGGELLDRILRQR--YFSEREASDVLCTITKTMDYLHSQGVVHR 539
Query: 131 DLKTQNVFLTRTN----IIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSNKPYNYK 186
DLK N+ + I+V D G A+ L + T T +++PE+ + Y+
Sbjct: 540 DLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAA 599
Query: 187 SDVWALGCCVYEM-ATLKHAFNAKD--MNSLVYRIIEGKLPPMPRDY---SPELAELIRT 240
D+W+LG +Y M A N D ++ RI GK ++ S +++
Sbjct: 600 CDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSK 659
Query: 241 MLSKRPEERPSVRSILRQPYI 261
ML P +R + +L+ P++
Sbjct: 660 MLHVDPHQRLTAMQVLKHPWV 680
>gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform a [Homo sapiens]
Length = 733
Score = 136 bits (343), Expect = 7e-32
Identities = 81/260 (31%), Positives = 140/260 (53%), Gaps = 12/260 (4%)
Query: 9 LRVVGKGSYGEVTLVKHRRD---GKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNI 65
L+V+G+GSYG+V LV+ + G+ Y +K L R+R ++ E +L+++ HP I
Sbjct: 62 LKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEVNHPFI 121
Query: 66 VTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQYLHEK 125
V +++ +G LY+++ F GGDL+ +L ++ + E V + ++A+AL +LH
Sbjct: 122 VKLHYAFQT-EGKLYLILDFLRGGDLFTRLSKEV--MFTEEDVKFYLAELALALDHLHSL 178
Query: 126 HILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSNKPYNY 185
I++RDLK +N+ L IK+ D G+++ +H A + GT YM+PE+ + + +
Sbjct: 179 GIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGHTQ 238
Query: 186 KSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRTMLSKR 245
+D W+ G ++EM T F KD + I++ KL MP+ S E L+R + +
Sbjct: 239 SADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKL-GMPQFLSGEAQSLLRALFKRN 297
Query: 246 PEER-----PSVRSILRQPY 260
P R V I R P+
Sbjct: 298 PCNRLGAGIDGVEEIKRHPF 317
Score = 91.7 bits (226), Expect = 3e-18
Identities = 66/261 (25%), Positives = 122/261 (46%), Gaps = 20/261 (7%)
Query: 12 VGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQL-KHPNIVTYKE 70
+G GSY H+ +Y +K ++ + +R +E ++L + +HPNI+T K+
Sbjct: 421 IGVGSYSVCKRCVHKATDTEYAVKIID------KSKRDPSEEIEILLRYGQHPNIITLKD 474
Query: 71 SWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQYLHEKHILHR 130
++ G +Y+VM GG+L ++ Q+ E + + I + YLH + ++HR
Sbjct: 475 VYDDGK-FVYLVMELMRGGELLDRILRQR--YFSEREASDVLCTITKTMDYLHSQGVVHR 531
Query: 131 DLKTQNVFLTRTN----IIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSNKPYNYK 186
DLK N+ + I+V D G A+ L + T T +++PE+ + Y+
Sbjct: 532 DLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAA 591
Query: 187 SDVWALGCCVYEM-ATLKHAFNAKD--MNSLVYRIIEGKLPPMPRDY---SPELAELIRT 240
D+W+LG +Y M A N D ++ RI GK ++ S +++
Sbjct: 592 CDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSK 651
Query: 241 MLSKRPEERPSVRSILRQPYI 261
ML P +R + +L+ P++
Sbjct: 652 MLHVDPHQRLTAMQVLKHPWV 672
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 135 bits (341), Expect = 1e-31
Identities = 108/375 (28%), Positives = 173/375 (46%), Gaps = 37/375 (9%)
Query: 2 PLAAYCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLK 61
P + + VVG G+YG+V +H + G+ IK +++ + E + E +L +
Sbjct: 21 PAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV---TEDEEEEIKLEINMLKKYS 77
Query: 62 HP-NIVTY-----KESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQI 115
H NI TY K+S G D L++VM FC G + +K KG L E+ + +I
Sbjct: 78 HHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREI 137
Query: 116 AMALQYLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSP 175
L +LH H++HRD+K QNV LT +K+ D G++ L+ +T IGTPY+M+P
Sbjct: 138 LRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
Query: 176 ELFS-----NKPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPP---MP 227
E+ + + Y+Y+SD+W+ G EMA + A DM+ + + + PP
Sbjct: 198 EVIACDENPDATYDYRSDLWSCGITAIEMA--EGAPPLCDMHPMRALFLIPRNPPPRLKS 255
Query: 228 RDYSPELAELIRTMLSKRPEERPSVRSILRQPYIK-----RQISFFLEATKIKTSKNNIK 282
+ +S + I L K +RPS +L+ P+I+ RQ+ L+ +T K K
Sbjct: 256 KKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRK---K 312
Query: 283 NGDSQSKPFATVVSGEAESNHEVIHPQPLSSEGSQTYIMGEGKC------LSQEKPRASG 336
G+ + SG E EV P+ S + GE L QE S
Sbjct: 313 RGEKDETEYE--YSGSEEEEEEV--PEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSE 368
Query: 337 LLKSPASLKAHTCKQ 351
L+ L+ ++
Sbjct: 369 ALRRQQLLQEQQLRE 383
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 135 bits (341), Expect = 1e-31
Identities = 108/375 (28%), Positives = 173/375 (46%), Gaps = 37/375 (9%)
Query: 2 PLAAYCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLK 61
P + + VVG G+YG+V +H + G+ IK +++ + E + E +L +
Sbjct: 21 PAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV---TEDEEEEIKLEINMLKKYS 77
Query: 62 HP-NIVTY-----KESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQI 115
H NI TY K+S G D L++VM FC G + +K KG L E+ + +I
Sbjct: 78 HHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREI 137
Query: 116 AMALQYLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSP 175
L +LH H++HRD+K QNV LT +K+ D G++ L+ +T IGTPY+M+P
Sbjct: 138 LRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
Query: 176 ELFS-----NKPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPP---MP 227
E+ + + Y+Y+SD+W+ G EMA + A DM+ + + + PP
Sbjct: 198 EVIACDENPDATYDYRSDLWSCGITAIEMA--EGAPPLCDMHPMRALFLIPRNPPPRLKS 255
Query: 228 RDYSPELAELIRTMLSKRPEERPSVRSILRQPYIK-----RQISFFLEATKIKTSKNNIK 282
+ +S + I L K +RPS +L+ P+I+ RQ+ L+ +T K K
Sbjct: 256 KKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRK---K 312
Query: 283 NGDSQSKPFATVVSGEAESNHEVIHPQPLSSEGSQTYIMGEGKC------LSQEKPRASG 336
G+ + SG E EV P+ S + GE L QE S
Sbjct: 313 RGEKDETEYE--YSGSEEEEEEV--PEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSE 368
Query: 337 LLKSPASLKAHTCKQ 351
L+ L+ ++
Sbjct: 369 ALRRQQLLQEQQLRE 383
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.130 0.366
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,465,352
Number of Sequences: 37866
Number of extensions: 1526036
Number of successful extensions: 8591
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 805
Number of HSP's successfully gapped in prelim test: 274
Number of HSP's that attempted gapping in prelim test: 5402
Number of HSP's gapped (non-prelim): 1725
length of query: 841
length of database: 18,247,518
effective HSP length: 111
effective length of query: 730
effective length of database: 14,044,392
effective search space: 10252406160
effective search space used: 10252406160
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.