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Search of human proteins with 148762940
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|148762940 DVL-binding protein DAPLE [Homo sapiens]
(2028 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|148762940 DVL-binding protein DAPLE [Homo sapiens] 3959 0.0
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 1607 0.0
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 1591 0.0
gi|88196790 coiled-coil domain containing 88 [Homo sapiens] 513 e-145
gi|55770834 centromere protein F [Homo sapiens] 181 5e-45
gi|14165274 golgi-associated microtubule-binding protein HOOK3 [... 174 1e-42
gi|21735548 centrosomal protein 2 [Homo sapiens] 171 9e-42
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 170 1e-41
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 170 1e-41
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 170 1e-41
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 170 1e-41
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 170 1e-41
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 169 2e-41
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 169 3e-41
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 168 4e-41
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 168 4e-41
gi|71061468 centromere protein E [Homo sapiens] 168 4e-41
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 168 4e-41
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 168 4e-41
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 168 4e-41
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 168 4e-41
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 168 4e-41
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 168 4e-41
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 168 4e-41
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 168 4e-41
gi|156104908 myosin heavy chain 6 [Homo sapiens] 168 6e-41
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 167 1e-40
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 167 1e-40
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 166 2e-40
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens] 166 2e-40
>gi|148762940 DVL-binding protein DAPLE [Homo sapiens]
Length = 2028
Score = 3959 bits (10266), Expect = 0.0
Identities = 2028/2028 (100%), Positives = 2028/2028 (100%)
Query: 1 MDVTVSELLELFLQSPLVTWVKTFGPFGSGSQDNLTMYMDLVDGIFLNQIMLQIDPRPTN 60
MDVTVSELLELFLQSPLVTWVKTFGPFGSGSQDNLTMYMDLVDGIFLNQIMLQIDPRPTN
Sbjct: 1 MDVTVSELLELFLQSPLVTWVKTFGPFGSGSQDNLTMYMDLVDGIFLNQIMLQIDPRPTN 60
Query: 61 QRINKHVNNDVNLRIQNLTILVRNIKTYYQEVLQQLIVMNLPNVLMIGRDPLSGKSMEEI 120
QRINKHVNNDVNLRIQNLTILVRNIKTYYQEVLQQLIVMNLPNVLMIGRDPLSGKSMEEI
Sbjct: 61 QRINKHVNNDVNLRIQNLTILVRNIKTYYQEVLQQLIVMNLPNVLMIGRDPLSGKSMEEI 120
Query: 121 KKVLLLVLGCAVQCERKEEFIERIKQLDIETQAGIVAHIQEVTHNQENVFDLQWLELPDV 180
KKVLLLVLGCAVQCERKEEFIERIKQLDIETQAGIVAHIQEVTHNQENVFDLQWLELPDV
Sbjct: 121 KKVLLLVLGCAVQCERKEEFIERIKQLDIETQAGIVAHIQEVTHNQENVFDLQWLELPDV 180
Query: 181 APEELEALSRSMVLHLRRLIDQRDECTELIVDLTQERDYLQAQHPPSPIKSSSADSTPSP 240
APEELEALSRSMVLHLRRLIDQRDECTELIVDLTQERDYLQAQHPPSPIKSSSADSTPSP
Sbjct: 181 APEELEALSRSMVLHLRRLIDQRDECTELIVDLTQERDYLQAQHPPSPIKSSSADSTPSP 240
Query: 241 TSSLSSEDKQHLAVELADTKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQKVKQENIQ 300
TSSLSSEDKQHLAVELADTKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQKVKQENIQ
Sbjct: 241 TSSLSSEDKQHLAVELADTKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQKVKQENIQ 300
Query: 301 LAADARSARAYRDELDSLREKANRVERLELELTRCKEKLHDVDFYKARMEELREDNIILI 360
LAADARSARAYRDELDSLREKANRVERLELELTRCKEKLHDVDFYKARMEELREDNIILI
Sbjct: 301 LAADARSARAYRDELDSLREKANRVERLELELTRCKEKLHDVDFYKARMEELREDNIILI 360
Query: 361 ETKAMLEEQLTAARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIEELLEENMVLEI 420
ETKAMLEEQLTAARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIEELLEENMVLEI
Sbjct: 361 ETKAMLEEQLTAARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIEELLEENMVLEI 420
Query: 421 AQKQSMNESAHLGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQ 480
AQKQSMNESAHLGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQ
Sbjct: 421 AQKQSMNESAHLGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQ 480
Query: 481 GLRDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQ 540
GLRDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQ
Sbjct: 481 GLRDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQ 540
Query: 541 LQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVT 600
LQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVT
Sbjct: 541 LQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVT 600
Query: 601 EANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGRLARKVTSLETATEK 660
EANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGRLARKVTSLETATEK
Sbjct: 601 EANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGRLARKVTSLETATEK 660
Query: 661 VEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVETMRFTS 720
VEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVETMRFTS
Sbjct: 661 VEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVETMRFTS 720
Query: 721 TKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSSH 780
TKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSSH
Sbjct: 721 TKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSSH 780
Query: 781 KTQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKE 840
KTQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKE
Sbjct: 781 KTQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKE 840
Query: 841 AKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDNRDLTKQV 900
AKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDNRDLTKQV
Sbjct: 841 AKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDNRDLTKQV 900
Query: 901 TVHARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSDTKYKIL 960
TVHARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSDTKYKIL
Sbjct: 901 TVHARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSDTKYKIL 960
Query: 961 EGRNESALKTTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLKKECETLRQNQGEGQHL 1020
EGRNESALKTTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLKKECETLRQNQGEGQHL
Sbjct: 961 EGRNESALKTTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLKKECETLRQNQGEGQHL 1020
Query: 1021 QNSFKHPAGKTAASHQGKEAWGPGHKEATMELLRVKDRAIELERNNAALQAEKQLLKEQL 1080
QNSFKHPAGKTAASHQGKEAWGPGHKEATMELLRVKDRAIELERNNAALQAEKQLLKEQL
Sbjct: 1021 QNSFKHPAGKTAASHQGKEAWGPGHKEATMELLRVKDRAIELERNNAALQAEKQLLKEQL 1080
Query: 1081 QHLETQNVTFSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQ 1140
QHLETQNVTFSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQ
Sbjct: 1081 QHLETQNVTFSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQ 1140
Query: 1141 NHHTAKETENESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHR 1200
NHHTAKETENESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHR
Sbjct: 1141 NHHTAKETENESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHR 1200
Query: 1201 NLELEHKELGERHGDMLKRKAELEEREKVLTTEREALQQEQRTNALAMGENQRLRGELDR 1260
NLELEHKELGERHGDMLKRKAELEEREKVLTTEREALQQEQRTNALAMGENQRLRGELDR
Sbjct: 1201 NLELEHKELGERHGDMLKRKAELEEREKVLTTEREALQQEQRTNALAMGENQRLRGELDR 1260
Query: 1261 VNFLHHQLKGEYEELHAHTKELKTSLNNAQLELNRWQARFDELKEQHQTMDISLTKLDNH 1320
VNFLHHQLKGEYEELHAHTKELKTSLNNAQLELNRWQARFDELKEQHQTMDISLTKLDNH
Sbjct: 1261 VNFLHHQLKGEYEELHAHTKELKTSLNNAQLELNRWQARFDELKEQHQTMDISLTKLDNH 1320
Query: 1321 CELLSRLKGNLEEENHHLLSQIQLLSQQNQMLLEQNMENKEQYHEEQKQYIDKLNALRRH 1380
CELLSRLKGNLEEENHHLLSQIQLLSQQNQMLLEQNMENKEQYHEEQKQYIDKLNALRRH
Sbjct: 1321 CELLSRLKGNLEEENHHLLSQIQLLSQQNQMLLEQNMENKEQYHEEQKQYIDKLNALRRH 1380
Query: 1381 KEKLEEKIMDQYKFYDPPPKKKNHWIGAKALVKLIKPKKEGSRERLKSTVDSPPWQLESS 1440
KEKLEEKIMDQYKFYDPPPKKKNHWIGAKALVKLIKPKKEGSRERLKSTVDSPPWQLESS
Sbjct: 1381 KEKLEEKIMDQYKFYDPPPKKKNHWIGAKALVKLIKPKKEGSRERLKSTVDSPPWQLESS 1440
Query: 1441 DPASPAASQPLRSQAENPDTPALGSNCAEERDAHNGSVGKGPGDLKPKRGSPHRGSLDRT 1500
DPASPAASQPLRSQAENPDTPALGSNCAEERDAHNGSVGKGPGDLKPKRGSPHRGSLDRT
Sbjct: 1441 DPASPAASQPLRSQAENPDTPALGSNCAEERDAHNGSVGKGPGDLKPKRGSPHRGSLDRT 1500
Query: 1501 DASTDLAMRSWPSELGSRTCSTSATTTAPSNSTPIARHPGRTKGYNSDDNLCEPSLEFEV 1560
DASTDLAMRSWPSELGSRTCSTSATTTAPSNSTPIARHPGRTKGYNSDDNLCEPSLEFEV
Sbjct: 1501 DASTDLAMRSWPSELGSRTCSTSATTTAPSNSTPIARHPGRTKGYNSDDNLCEPSLEFEV 1560
Query: 1561 PNHRQYVSRPSSLESSRNTSSNSSPLNLKGSSEQLHGRSESFSSEDLIPSRDLATLPREA 1620
PNHRQYVSRPSSLESSRNTSSNSSPLNLKGSSEQLHGRSESFSSEDLIPSRDLATLPREA
Sbjct: 1561 PNHRQYVSRPSSLESSRNTSSNSSPLNLKGSSEQLHGRSESFSSEDLIPSRDLATLPREA 1620
Query: 1621 STPGRNALGRHEYPLPRNGPLPQEGAQKRGTAPPYVGVRPCSASPSSEMVTLEEFLEESN 1680
STPGRNALGRHEYPLPRNGPLPQEGAQKRGTAPPYVGVRPCSASPSSEMVTLEEFLEESN
Sbjct: 1621 STPGRNALGRHEYPLPRNGPLPQEGAQKRGTAPPYVGVRPCSASPSSEMVTLEEFLEESN 1680
Query: 1681 RSSPTHDTPSCRDDLLSDYFRKASDPPAIGGQPGPPAKKEGAKMPTNFVAPTVKMAAPTS 1740
RSSPTHDTPSCRDDLLSDYFRKASDPPAIGGQPGPPAKKEGAKMPTNFVAPTVKMAAPTS
Sbjct: 1681 RSSPTHDTPSCRDDLLSDYFRKASDPPAIGGQPGPPAKKEGAKMPTNFVAPTVKMAAPTS 1740
Query: 1741 EGRPLKPGQYVKPNFRLTEAEAPPSVAPRQAQPPQSLSLGRPRQAPVPPASHAPASRSAS 1800
EGRPLKPGQYVKPNFRLTEAEAPPSVAPRQAQPPQSLSLGRPRQAPVPPASHAPASRSAS
Sbjct: 1741 EGRPLKPGQYVKPNFRLTEAEAPPSVAPRQAQPPQSLSLGRPRQAPVPPASHAPASRSAS 1800
Query: 1801 LSRAFSLASADLLRASGPEACKQESPQKLGAPEALGGRETGSHTLQSPAPPSSHSLARER 1860
LSRAFSLASADLLRASGPEACKQESPQKLGAPEALGGRETGSHTLQSPAPPSSHSLARER
Sbjct: 1801 LSRAFSLASADLLRASGPEACKQESPQKLGAPEALGGRETGSHTLQSPAPPSSHSLARER 1860
Query: 1861 TPLVGKAGSSCQGPGPRSRPLDTRRFSLAPPKEERLAPLHQSATAPAIATAGAGAAAAGS 1920
TPLVGKAGSSCQGPGPRSRPLDTRRFSLAPPKEERLAPLHQSATAPAIATAGAGAAAAGS
Sbjct: 1861 TPLVGKAGSSCQGPGPRSRPLDTRRFSLAPPKEERLAPLHQSATAPAIATAGAGAAAAGS 1920
Query: 1921 GSNSQLLHFSPAAAPAARTKPKAPPRSGEVATITPVRAGLSLSEGDGVPGQGCSEGLPAK 1980
GSNSQLLHFSPAAAPAARTKPKAPPRSGEVATITPVRAGLSLSEGDGVPGQGCSEGLPAK
Sbjct: 1921 GSNSQLLHFSPAAAPAARTKPKAPPRSGEVATITPVRAGLSLSEGDGVPGQGCSEGLPAK 1980
Query: 1981 SPGRSPDLAPHLGRALEDCSRGSVSKSSPASPEPGGDPQTVWYEYGCV 2028
SPGRSPDLAPHLGRALEDCSRGSVSKSSPASPEPGGDPQTVWYEYGCV
Sbjct: 1981 SPGRSPDLAPHLGRALEDCSRGSVSKSSPASPEPGGDPQTVWYEYGCV 2028
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 1607 bits (4160), Expect = 0.0
Identities = 876/1766 (49%), Positives = 1230/1766 (69%), Gaps = 54/1766 (3%)
Query: 8 LLELFLQSPLVTWVKTFGPFGSGSQDNLTMYMDLVDGIFLNQIMLQIDPRPTNQRINKHV 67
LLE F+ SPLVTWVKTFGP +G+ NL Y+ LVDG+FLNQ+MLQI+P+ +QR+NK V
Sbjct: 9 LLEQFMTSPLVTWVKTFGPLAAGNGTNLDEYVALVDGVFLNQVMLQINPKLESQRVNKKV 68
Query: 68 NNDVNLRIQNLTILVRNIKTYYQEVLQQLIVMNLPNVLMIGRDPLSGKSMEEIKKVLLLV 127
NND +LR+ NL+ILVR IK YYQE LQQLI+M+LPNVL+IG++P S + EE+KK+LLL+
Sbjct: 69 NNDASLRMHNLSILVRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSEQGTEEVKKLLLLL 128
Query: 128 LGCAVQCERKEEFIERIKQLDIETQAGIVAHIQEVTHNQENVFDLQWLELPDVAPEELEA 187
LGCAVQC++KEEFIERI+ LD +T+A + AHIQEVTHNQENVFDLQW+E+ D++ E++E
Sbjct: 129 LGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEP 188
Query: 188 LSRSMVLHLRRLIDQRDECTELIVDLTQERDYLQAQHPPSPIKSSSADSTPSPTSSLSSE 247
L ++M LHL+RLID+RDE +E I++L++ERD L P SSSA S +E
Sbjct: 189 LLKNMALHLKRLIDERDEHSETIIELSEERDGLHFL----PHASSSAQSPCGSPGMKRTE 244
Query: 248 DKQHLAVELADTKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARS 307
+QHL+VELAD KA++RR+RQELE+KTEQL+D + E++Q+ +EL++++QEN+ L +DARS
Sbjct: 245 SRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARS 304
Query: 308 ARAYRDELDSLREKANRVERLELELTRCKEKLHDVDFYKARMEELREDNIILIETKAMLE 367
AR YRDELD+LREKA RV++LE E++R KE+LHD++FYKAR+EEL+EDN +L+ETK MLE
Sbjct: 305 ARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLE 364
Query: 368 EQLTAARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIEELLEENMVLEIAQKQSMN 427
+QL RAR DK+HELEKENLQLK+KLHD+E++RD D+K+IEEL+EENM LE+AQKQSM+
Sbjct: 365 DQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMD 424
Query: 428 ESAHLGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASL 487
ES HLGWELEQ+S+ ++LS+A +KS E+NE SSR+LKLE ENQSL T++ LR
Sbjct: 425 ESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVD 484
Query: 488 VLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSDMET 547
+E + K ++EKEN +LSKK+E L+ ++ +EKQS Q+ + LS++L++EK QL+ +ET
Sbjct: 485 SVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIET 544
Query: 548 LKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEANGKLS 607
L+ + RQIK LEQE +HLN+ + SLR+RSQ+S+EAR+KD+EKENK LH+++ E + KLS
Sbjct: 545 LRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLS 604
Query: 608 QLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGRLARKVTSLETATEKVEALEHE 667
++EFEKRQ+ ++LE KEKGERAE+LE EL L++EN L +K+T+L+ EK+EALE E
Sbjct: 605 KIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQE 664
Query: 668 SQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVETMRFTSTKLAQME 727
+ L+ ENR L+K+LD+ +N++ QLE LE++N QLD ENLELRR VE+++ S K+AQ++
Sbjct: 665 NSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQ 724
Query: 728 RENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSSHKTQTLES 787
EN++LE EKE+L+K ++LLKA KK+ERLE+SYQ + EN RLQ++LE+S+ K Q LES
Sbjct: 725 LENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLES 784
Query: 788 ELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQQ 847
EL +LE E Q L+++LE L++++ +LE EK+ K+LEQE +QLEKDKK LEKE KRL QQ
Sbjct: 785 ELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQ 844
Query: 848 VELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDNRDLTKQVTVHARTL 907
E+KD L+++ K+ +EKE++ L KE+ +++ +LKELEK+N++L K+ T+ +TL
Sbjct: 845 AEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTL 904
Query: 908 TTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSDTKYKILEGRNESA 967
TLREDLV EKLK+QQ++++L+KL+ ELEK+GLN+E LL ++ S D++YK+LE + ES
Sbjct: 905 VTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLEST 964
Query: 968 LKTTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHP 1027
LK +L +KEEKI LEA++EE + N+QL EL+ +KK E L+Q Q E + +Q+S
Sbjct: 965 LKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSS---- 1020
Query: 1028 AGKTAASHQGKEAWGPGHKEATMELLRVKDRAIELERNNAALQAEKQLLKEQLQHLETQN 1087
+ K W +E T ELL+VKDR IE+ERNNA LQAEKQ LK QL+ LETQN
Sbjct: 1021 --PPISGEDNK--WERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQN 1076
Query: 1088 VTFSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKE 1147
+QIL LQ+Q+ LQE NTTLQTQ AKLQVENSTL+SQS +L Q L ++ E
Sbjct: 1077 NNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLE 1136
Query: 1148 TENESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHK 1207
ENES+ +++E L + Y++L++DHE L LHERQ++EYE+LI +H LK+ H+NLE+EH+
Sbjct: 1137 NENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHR 1196
Query: 1208 ELGERHGDMLKRKAELEEREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQ 1267
+L +R+ +LK+K +LE+ EK+L E+E + E + + E ++L GE DR+N + Q
Sbjct: 1197 DLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQ 1256
Query: 1268 LKGEYEELHAHTKELKTSLNNAQLELNRWQARFDELKEQHQTMDISLTKLDNHCELLSRL 1327
L E E L K LK+ LNN++LE R +A F +LKEQ+Q +DI+ TKL+N CELLS+L
Sbjct: 1257 LLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQL 1316
Query: 1328 KGNLEEENHHLLSQIQLLSQQNQMLLEQNMENKEQYHEEQKQYIDKLNALRRHKEKLEEK 1387
KGNLEEEN HLL QIQ L QN+ LLEQNME+K+ +H EQ+QYIDKLN LRR KEKLEEK
Sbjct: 1317 KGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEK 1376
Query: 1388 IMDQYKFYDP-PPKKKNHWIGAKALVKLIKPKKEGSRERLKSTVDSPPWQLESSDPASPA 1446
IMDQYKFYDP PP+++ +WI K + KLIK KK+ +RER KS +P SD +
Sbjct: 1377 IMDQYKFYDPSPPRRRGNWITLK-MRKLIKSKKDINRERQKSLTLTP----TRSDSSEGF 1431
Query: 1447 ASQPLRSQAENPDTPALGSNCAEERDAHNGSVGKGPGDLKPKR--GSPHRGSLDRTDAST 1504
P ++ D+ ++GSN E+ DL GS + +
Sbjct: 1432 LQLP---HQDSQDSSSVGSNSLEDGQTLGTKKSSTMNDLVQSMVLAGQWTGSTENLEVPD 1488
Query: 1505 DLAMRSWPSELGSRTCSTSATTTAPSNSTPIARHPG--RTKGYNSDDNLCEPSL-EFEVP 1561
D++ ELG+ ST+A + NS+ R K S +++ + +
Sbjct: 1489 DISTGKRRKELGAMAFSTTAINFSTVNSSAGFRSKQLVNNKDTTSFEDISPQGVSDDSST 1548
Query: 1562 NHRQYVSRPSSLESSR----NTSSNSSPLNLKGSSEQLHGRSESFSSEDLIPSRDLATLP 1617
R + SRP+SL+S R N+++N+S +K + R +S SS + D
Sbjct: 1549 GSRVHASRPASLDSGRTSTSNSNNNASLHEVKAGAVNNQSRPQSHSSGEFSLLHDHEAWS 1608
Query: 1618 REASTPGRNALGRHEYPLPRNGPLPQEGAQKRGTAPPYVGVRPCSASPSSEMVTLEEFLE 1677
S+P + + R+ P+ Q + + + + + SP SE+VTL++FLE
Sbjct: 1609 SSGSSPIQYLKRQ-----TRSSPVLQHKISETLESRHH---KIKTGSPGSEVVTLQQFLE 1660
Query: 1678 ESNRSSPTHDTPSCRDDLLSDYFRKASDPPAIGGQPGPP----AKKEGAKMPTNFVAPTV 1733
ESN+ + S +++LL + + S G+ P A+ K P +F
Sbjct: 1661 ESNKLTSVQIKSSSQENLLDEVMKSLSVSSDFLGKDKPVSCGLARSVSGKTPGDFY---- 1716
Query: 1734 KMAAPTSEGRPLKPGQYVKPNFRLTE 1759
+ R KP ++++P R TE
Sbjct: 1717 -------DRRTTKP-EFLRPGPRKTE 1734
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 1591 bits (4120), Expect = 0.0
Identities = 879/1795 (48%), Positives = 1235/1795 (68%), Gaps = 85/1795 (4%)
Query: 8 LLELFLQSPLVTWVKTFGPFGSGSQDNLTMYMDLVDGIFLNQIMLQIDPRPTNQRINKHV 67
LLE F+ SPLVTWVKTFGP +G+ NL Y+ LVDG+FLNQ+MLQI+P+ +QR+NK V
Sbjct: 9 LLEQFMTSPLVTWVKTFGPLAAGNGTNLDEYVALVDGVFLNQVMLQINPKLESQRVNKKV 68
Query: 68 NNDVNLRIQNLTILVRNIKTYYQEVLQQLIVMNLPNVLMIGRDPLSGKSMEEIKKVLLLV 127
NND +LR+ NL+ILVR IK YYQE LQQLI+M+LPNVL+IG++P S + EE+KK+LLL+
Sbjct: 69 NNDASLRMHNLSILVRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSEQGTEEVKKLLLLL 128
Query: 128 LGCAVQCERKEEFIERIKQLDIETQAGIVAHIQEVTHNQENVFDLQWLELPDVAPEELEA 187
LGCAVQC++KEEFIERI+ LD +T+A + AHIQEVTHNQENVFDLQW+E+ D++ E++E
Sbjct: 129 LGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEP 188
Query: 188 LSRSMVLHLRRLIDQRDECTELIVDLTQERDYLQAQHPPSPIKSSSADSTPSPTSSLSSE 247
L ++M LHL+RLID+RDE +E I++L++ERD L P SSSA S +E
Sbjct: 189 LLKNMALHLKRLIDERDEHSETIIELSEERDGLHFL----PHASSSAQSPCGSPGMKRTE 244
Query: 248 DKQHLAVELADTKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARS 307
+QHL+VELAD KA++RR+RQELE+KTEQL+D + E++Q+ +EL++++QEN+ L +DARS
Sbjct: 245 SRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARS 304
Query: 308 ARAYRDELDSLREKANRVERLELELTRCKEKLHDVDFYKARMEELREDNIILIETKAMLE 367
AR YRDELD+LREKA RV++LE E++R KE+LHD++FYKAR+EEL+EDN +L+ETK MLE
Sbjct: 305 ARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLE 364
Query: 368 EQLTAARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIEELLEENMVLEIAQKQSMN 427
+QL RAR DK+HELEKENLQLK+KLHD+E++RD D+K+IEEL+EENM LE+AQKQSM+
Sbjct: 365 DQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMD 424
Query: 428 ESAHLGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASL 487
ES HLGWELEQ+S+ ++LS+A +KS E+NE SSR+LKLE ENQSL T++ LR
Sbjct: 425 ESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVD 484
Query: 488 VLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSDMET 547
+E + K ++EKEN +LSKK+E L+ ++ +EKQS Q+ + LS++L++EK QL+ +ET
Sbjct: 485 SVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIET 544
Query: 548 LKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEANGKLS 607
L+ + RQIK LEQE +HLN+ + SLR+RSQ+S+EAR+KD+EKENK LH+++ E + KLS
Sbjct: 545 LRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLS 604
Query: 608 QLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGRLARKVTSLETATEKVEALEHE 667
++EFEKRQ+ ++LE KEKGERAE+LE EL L++EN L +K+T+L+ EK+EALE E
Sbjct: 605 KIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQE 664
Query: 668 SQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVETMRFTSTKLAQME 727
+ L+ ENR L+K+LD+ +N++ QLE LE++N QLD ENLELRR VE+++ S K+AQ++
Sbjct: 665 NSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQ 724
Query: 728 RENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSSHKTQTLES 787
EN++LE EKE+L+K ++LLKA KK+ERLE+SYQ + EN RLQ++LE+S+ K Q LES
Sbjct: 725 LENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLES 784
Query: 788 ELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQQ 847
EL +LE E Q L+++LE L++++ +LE EK+ K+LEQE +QLEKDKK LEKE KRL QQ
Sbjct: 785 ELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQ 844
Query: 848 VELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDNRDLTKQVTVHARTL 907
E+KD L+++ K+ +EKE++ L KE+ +++ +LKELEK+N++L K+ T+ +TL
Sbjct: 845 AEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTL 904
Query: 908 TTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSDTKYKILEGRNESA 967
TLREDLV EKLK+QQ++++L+KL+ ELEK+GLN+E LL D+ +D +YK+LE + ES
Sbjct: 905 VTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLL-HDEQSTDDRYKLLESKLEST 963
Query: 968 LKTTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHP 1027
LK +L +KEEKI LEA++EE + N+QL EL+ +KK E L+Q Q E + +Q+S
Sbjct: 964 LKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSS---- 1019
Query: 1028 AGKTAASHQGKEAWGPGHKEATMELLRVKDRAIELERNNAALQAEKQLLKEQLQHLETQN 1087
+ K W +E T ELL+VKDR IE+ERNNA LQAEKQ LK QL+ LETQN
Sbjct: 1020 --PPISGEDNK--WERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQN 1075
Query: 1088 VTFSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKE 1147
+QIL LQ+Q+ LQE NTTLQTQ AKLQVENSTL+SQS +L Q L ++ E
Sbjct: 1076 NNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLE 1135
Query: 1148 TENESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHK 1207
ENES+ +++E L + Y++L++DHE L LHERQ++EYE+LI +H LK+ H+NLE+EH+
Sbjct: 1136 NENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHR 1195
Query: 1208 ELGERHGDMLKRKAELEEREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQ 1267
+L +R+ +LK+K +LE+ EK+L E+E + E + + E ++L GE DR+N + Q
Sbjct: 1196 DLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQ 1255
Query: 1268 LKGEYEELHAHTKELKTSLNNAQLELNRWQARFDELKEQHQTMDISLTKLDNHCELLSRL 1327
L E E L K LK+ LNN++LE R +A F +LKEQ+Q +DI+ TKL+N CELLS+L
Sbjct: 1256 LLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQL 1315
Query: 1328 KGNLEEENHHLLSQIQLLSQQNQMLLEQNMENKEQYHEEQKQYIDKLNALRRHKEKLEEK 1387
KGNLEEEN HLL QIQ L QN+ LLEQNME+K+ +H EQ+QYIDKLN LRR KEKLEEK
Sbjct: 1316 KGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEK 1375
Query: 1388 IMDQYKFYDP-PPKKKNHWIGAKALVKLIKPKKEGSRERLKSTVDSPPWQLESSDPASPA 1446
IMDQYKFYDP PP+++ +WI K + KLIK KK+ +RER KS +P SD +
Sbjct: 1376 IMDQYKFYDPSPPRRRGNWITLK-MRKLIKSKKDINRERQKSLTLTP----TRSDSSEGF 1430
Query: 1447 ASQPLRSQAENPDTPALGSNCAEERDAHNGS------------VGKGPGDLKPKRGSPHR 1494
P ++ D+ ++GSN E+ + P D K K + +R
Sbjct: 1431 LQLP---HQDSQDSSSVGSNSLEDGQTLGTKKSSMVALKRLPFLRNRPKD-KDKMKACYR 1486
Query: 1495 -------------------GSLDRTDASTDLAMRSWPSELGSRTCSTSATTTAPSNSTPI 1535
GS + + D++ ELG+ ST+A + NS+
Sbjct: 1487 RSMSMNDLVQSMVLAGQWTGSTENLEVPDDISTGKRRKELGAMAFSTTAINFSTVNSSAG 1546
Query: 1536 ARHPG--RTKGYNSDDNLCEPSL-EFEVPNHRQYVSRPSSLESSR----NTSSNSSPLNL 1588
R K S +++ + + R + SRP+SL+S R N+++N+S +
Sbjct: 1547 FRSKQLVNNKDTTSFEDISPQGVSDDSSTGSRVHASRPASLDSGRTSTSNSNNNASLHEV 1606
Query: 1589 KGSSEQLHGRSESFSSEDLIPSRDLATLPREASTPGRNALGRHEYPLPRNGPLPQEGAQK 1648
K + R +S SS + D S+P + + R+ P+ Q +
Sbjct: 1607 KAGAVNNQSRPQSHSSGEFSLLHDHEAWSSSGSSPIQYLKRQ-----TRSSPVLQHKISE 1661
Query: 1649 RGTAPPYVGVRPCSASPSSEMVTLEEFLEESNRSSPTHDTPSCRDDLLSDYFRKASDPPA 1708
+ + + + SP SE+VTL++FLEESN+ + S +++LL + + S
Sbjct: 1662 TLESRHH---KIKTGSPGSEVVTLQQFLEESNKLTSVQIKSSSQENLLDEVMKSLSVSSD 1718
Query: 1709 IGGQPGPP----AKKEGAKMPTNFVAPTVKMAAPTSEGRPLKPGQYVKPNFRLTE 1759
G+ P A+ K P +F + R KP ++++P R TE
Sbjct: 1719 FLGKDKPVSCGLARSVSGKTPGDFY-----------DRRTTKP-EFLRPGPRKTE 1761
>gi|88196790 coiled-coil domain containing 88 [Homo sapiens]
Length = 1476
Score = 513 bits (1320), Expect = e-145
Identities = 422/1408 (29%), Positives = 687/1408 (48%), Gaps = 154/1408 (10%)
Query: 38 YMDLVDGIFLNQIMLQIDPRPTN-QRINKHVNNDVNLRIQNLTILVRNIKTYYQEVLQQL 96
++ L DG L +++ I P R+ + ++ R+ NL L ++ +YQE LQ L
Sbjct: 53 FLRLSDGALLLRVLGIIAPSSRGGPRMLRGLDGPAAWRVWNLNHLWGRLRDFYQEELQLL 112
Query: 97 IVMNLPNVLMIGRDPLSGKSMEEIKKVLLLVLGCAVQCERKEEFIERIKQLDIETQAGIV 156
I+ P++ +G DPLS +++E+++ VL L+LG +VQCE +E FI I+ L +E Q+ +
Sbjct: 113 ILSPPPDLQTLGFDPLSEEAVEQLEGVLRLLLGASVQCEHRELFIRHIQGLSLEVQSELA 172
Query: 157 AHIQEVTHNQENV-FDLQWLELPDVAPEELEALSRSMVLHLRRLIDQRDECTELIVDLTQ 215
A IQEVT V L + ++AP ELE LSRS++ L +L +RD + + +L
Sbjct: 173 AAIQEVTQPGAGVVLALSGPDPGELAPAELEMLSRSLMGTLSKLARERDLGAQRLAELLL 232
Query: 216 ERDYLQAQHPPSPIKSSSADSTPSPTSSLSSEDKQHLAVELADTKARLRRVRQELEDKTE 275
ER+ L P +P ++ + + HLA++LA+ KA+LRR+RQELE+K E
Sbjct: 233 EREPL-CLRPEAPSRAPAEGPS------------HHLALQLANAKAQLRRLRQELEEKAE 279
Query: 276 QLVDTRHEVDQLVLELQKVKQENIQLAADARSARAYRDELDSLREKANRVERLELELTRC 335
L+D++ EV L E+++++QE L+ A+ A YR+E ++LRE+A R+ RL+ EL RC
Sbjct: 280 LLLDSQAEVQGLEAEIRRLRQEAQALSGQAKRAELYREEAEALRERAGRLPRLQEELRRC 339
Query: 336 KEKLHDVDFYKARMEELREDNIILIETKAMLEEQLTAARARGDKVHELEKENLQLKSKLH 395
+E+L + YK+++EE R + +L +KA+LEEQL AAR R ++HE ++ENL L+++L
Sbjct: 340 RERLQAAEAYKSQLEEERVLSGVLEASKALLEEQLEAARERCARLHETQRENLLLRTRLG 399
Query: 396 DLELDRDTDKKRIEELLEENMVLEIAQKQSMNESAHLGWELEQLSKNADLSDASRKSFVF 455
+ + D+ + ++++L EEN+ LE+ ++S+ E L D
Sbjct: 400 EAHAELDSLRHQVDQLAEENVELELELQRSLEPPPGSPGEAPLAGAAPSLQD-------- 451
Query: 456 ELNECASSRILKLEKENQSLQS---TIQGLRDASLVLEESGLKCGELEKENHQLSKKIEK 512
E+ E + R+ LE+EN+ L+ +QG L E+ +E+ L E
Sbjct: 452 EVREAEAGRLRTLERENRELRGLLQVLQGQPGGQHPLLEA-------PREDPVLPVLEEA 504
Query: 513 LQTQLEREKQSNQDLETLSEE-----LIREKEQLQSDMETLKADKARQIKDLEQEKDHLN 567
QT + + S Q L + + L L S +E D ++ + L
Sbjct: 505 PQTPVAFD-HSPQGLVQKARDGGPQALDLAPPALDSVLEASAECPQAPDSDPQEAESPLQ 563
Query: 568 RAM-------WSLRERSQVSSEARMKDVEKENKALHQTVTEANGKLSQLEFEKRQLHRDL 620
A WS +E + +L + A + + + QL
Sbjct: 564 AAAMDPQASDWSPQESGSPVETQESPEKAGRRSSLQSPASVAPPQGPGTKIQAPQLLGGE 623
Query: 621 EQAKEKGERAEKLERELQRLQEENGRLARKVTSLETATEKVEALEHESQGLQLENRTLRK 680
+ +E + +L E L++E K E ++ ++E E +QGL L
Sbjct: 624 TEGREAPQG--ELVPEAWGLRQEGPE--HKPGPSEPSSVQLEEQEGPNQGLDLATGQAEA 679
Query: 681 SLDTLQNVSLQLEGLERD---NKQLDAENLELRRLVETMRFTSTKLAQMERENQQLEREK 737
+ +LEG RD K L V LA E + L E
Sbjct: 680 -----REHDQRLEGTVRDPAWQKPQQKSEGALEVQVWEGPIPGESLASGVAEQEALREEV 734
Query: 738 EELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSSHKTQTLESELGELEAERQ 797
+LR+ + ALG + E ++ + E RL + L + E E +A Q
Sbjct: 735 AQLRRKAE---ALGDELEAQARKLEAQNTEAARLSKELAQARRAEAEAHRE-AEAQAWEQ 790
Query: 798 ALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQQVELKDAVLDD 857
A R EA+ A +LE A ++R+AL + +A ++++ E+E RL Q E +
Sbjct: 791 ARLR--EAVEAAGQELESASQEREALVEALAAAGRERRQWEREGSRLRAQSEAAEE---- 844
Query: 858 STAKLSAVEKESRALDKELARCRDAAGKLKELEKDNRDLTKQVTVHARTLTTLREDLVLE 917
++ +E E R L+E E++ R+ L+ +L
Sbjct: 845 ---RMQVLESEGRQ-------------HLEEAERERREKE-----------ALQAELEKA 877
Query: 918 KLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSDTKYKILEGRNESALKTTLAMKEE 977
++ ++L + L+ L +ELE+ L R+ L+E +S +Y+ LE R E+ L+ KEE
Sbjct: 878 VVRGKELGARLEHLQRELEQAALERQEFLREKES-QHQRYQGLEQRLEAELQAAATSKEE 936
Query: 978 KIVLLEAQMEEKASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTAASHQG 1037
++ L+ + QLE EL L+ QG
Sbjct: 937 ALMELKTRA-------LQLEEELFQLR-------------------------------QG 958
Query: 1038 KEAWGPGHKEATMELLRVKD-RAIELERNNAALQAEKQLLKEQLQHLETQNVTFSSQILT 1096
GP K A +L+ ++ R IE+ER+NA L AEK L+ QLQHLE Q + +
Sbjct: 959 PAGLGP-KKRAEPQLVETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQE 1017
Query: 1097 LQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETENESLQRQ 1156
L QS QEH++ LQ + + L+++ L + L E E + ++
Sbjct: 1018 LLLQSQRAQEHSSRLQAEKSVLEIQGQELHRKLEVL--------------EEEVRAARQS 1063
Query: 1157 QEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGERHGDM 1216
QE+ +ALL+DH+ L L RQ AE E L+ +H LK R LEL H+EL RH +
Sbjct: 1064 QEETRGQQQALLRDHKALAQLQRRQEAELEGLLVRHRDLKANMRALELAHRELQGRHEQL 1123
Query: 1217 LKRKAELEEREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQLKGEYEELH 1276
++A +E +E L ERE L Q+ E +RL+ E DR L +L E EL
Sbjct: 1124 QAQRASVEAQEVALLAERERLMQDGHRQRGLEEELRRLQSEHDRAQMLLAELSRERGELQ 1183
Query: 1277 AHTKELKTSLNNAQLELNRWQARFDELKEQHQTMDISLTKLDNHCELLSRLKGNLEEENH 1336
EL+ L +LE + + + +L+E +Q +D+S +L CELL++L+ EEEN
Sbjct: 1184 GERGELRGRLARLELERAQLEMQSQQLRESNQQLDLSACRLTTQCELLTQLRSAQEEENR 1243
Query: 1337 HLLSQIQLLSQQNQMLLEQNMENKEQYHEEQKQYIDKLNALRRHKEKLEEKIMDQYKFYD 1396
LL+++Q LS++N+ LLE+++E+++ H EQ++Y+D+LNALRR K+KL EKIMDQY+ +
Sbjct: 1244 QLLAEVQALSRENRELLERSLESRDHLHREQREYLDQLNALRREKQKLVEKIMDQYRVLE 1303
Query: 1397 P---PPKKKNHWIGAKALVKLIKPKKEG 1421
P P KK W+ K + +L++P++EG
Sbjct: 1304 PVPLPRTKKGSWLADK-VKRLMRPRREG 1330
Score = 32.3 bits (72), Expect = 4.8
Identities = 37/153 (24%), Positives = 54/153 (35%), Gaps = 36/153 (23%)
Query: 1715 PPAKKEGAKMPTNFVA--PTVKMAAPTSEGRPLKPGQYVKPNFRLTEAEAPPSVAPRQAQ 1772
P + + A+ P A P +P G P++ + + R + ++P SVAP Q
Sbjct: 551 PDSDPQEAESPLQAAAMDPQASDWSPQESGSPVETQESPEKAGRRSSLQSPASVAPPQGP 610
Query: 1773 PPQSLSLGRPRQAPVPPASHAPASRSASLSRAFSLASADLLRASGPEACKQESPQKLGAP 1832
G QAP + G E +E+PQ P
Sbjct: 611 -------GTKIQAP---------------------------QLLGGETEGREAPQGELVP 636
Query: 1833 EALGGRETGSHTLQSPAPPSSHSLARERTPLVG 1865
EA G R+ G P+ PSS L + P G
Sbjct: 637 EAWGLRQEGPEHKPGPSEPSSVQLEEQEGPNQG 669
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 181 bits (460), Expect = 5e-45
Identities = 279/1207 (23%), Positives = 496/1207 (41%), Gaps = 197/1207 (16%)
Query: 281 RHEVDQLVLELQKVKQENIQLAADARSARAYRDELDSLREKANRVERLELELTRCKEKLH 340
+ ++ L L +++ EN++L L + ++ +VE L E+ KLH
Sbjct: 1766 QEDIHNLQLRVKETSNENLRL-------------LHVIEDRDRKVESLLNEMKELDSKLH 1812
Query: 341 DVDFYKARMEELREDNIILIETKAMLEEQLTAARARGDKVHELEKENLQLKSKLHDLELD 400
++E++ ++ + +A +E + V EL+KEN L KL D
Sbjct: 1813 --------LQEVQ----LMTKIEACIELEKI--------VGELKKENSDLSEKLEYFSCD 1852
Query: 401 RDTDKKRIEELLEENMVLEIAQKQSMNES-------AHLGWELEQLSKNADLSDASRKSF 453
+R+E N LE+ +S E + W+ L +LS +
Sbjct: 1853 HQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKA 1912
Query: 454 VFELN--------ECASSRILKLEKENQSLQSTIQGLRDA-SLVLEESGLKCGELEKENH 504
E E + L LEK+N++ Q I L + S+V E GEL+
Sbjct: 1913 SIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDT--- 1969
Query: 505 QLSKKIEKLQTQLEREKQSNQDLET----------LSEELIREKEQLQSDMETLKADKAR 554
+SKK L E+ K+ Q+LE+ ++E ++EK +L ++TL +D +
Sbjct: 1970 -MSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTEL---LQTLSSDVSE 2025
Query: 555 QIKDLEQEKDHLNRAMWSLRERSQVSS------EARMKDVEKENKALHQTVTEANGKLSQ 608
+KD K HL + SL + SQ S E ++ + KE + L + +LS+
Sbjct: 2026 LLKD----KTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSE 2081
Query: 609 LEFEKRQLHRDLEQAK-EKGERAEKLERELQRLQEENGRLARKVTSLETATEKVEALE-H 666
++EK + + LE A EKGE A +L QEE +L R + L E E + H
Sbjct: 2082 SDYEKLNVSKALEAALVEKGEFALRLSST----QEEVHQLRRGIEKLRVRIEADEKKQLH 2137
Query: 667 ESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQ--LDAENLELRRLVETMRFTSTKLA 724
++ L+ R D ++N+ +L+ E + + LDAEN + VET++ ++A
Sbjct: 2138 IAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAE--VETLKTQIEEMA 2195
Query: 725 Q----MERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQ-QSLESSS 779
+ E + L EKE L K + + + ++L S++S+ E + + Q E S
Sbjct: 2196 RSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESK 2255
Query: 780 HKTQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEK 839
+ L+++L EL AL D E ++ L+ ++ L + +L + EK
Sbjct: 2256 TAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEK 2315
Query: 840 EAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRD--AAGKLKELEKDNRDLT 897
+ + QQ++ + D ++ +E+E E+AR AA + + + + L
Sbjct: 2316 KQLCVLQQLKESEHHADLLKGRVENLEREL-----EIARTNQEHAALEAENSKGEVETLK 2370
Query: 898 KQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQ---ELEKVGLNRELLLQEDDSGSD 954
++ ++L L D+V + + + L++EL K + ELE + + E +LQE +
Sbjct: 2371 AKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQ-EK 2429
Query: 955 TKYKILEGRNESALKTTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLKKECETLRQNQ 1014
+ K L+T L E++ L E + + L S+++ L+ E L Q
Sbjct: 2430 VQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGL 2489
Query: 1015 GEGQH----LQNSFKHPAGKTAASHQGKEAWGPGHKEATMELLRVKDRAIELERNNAALQ 1070
E ++ LQ+S G GK+ +E + +++D+ +L + ++
Sbjct: 2490 DEAKNNYIVLQSSVN---GLIQEVEDGKQKLEKKDEEISRLKNQIQDQE-QLVSKLSQVE 2545
Query: 1071 AEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQSA 1130
E QL KEQ L V +I LQ ++A LQ+ LQ+ L+ E
Sbjct: 2546 GEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKM 2605
Query: 1131 ALTAQYTLLQNHHTAKETENESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIR 1190
+ + N TAKETE + + Q TA + E L R + E + L+
Sbjct: 2606 SFVEKV----NKMTAKETELQREMHEMAQKTAELQ------EELSGEKNRLAGELQLLLE 2655
Query: 1191 QHSCLKTLHRNLELEHKELGER----HGDMLKRKAELEE--------------------- 1225
+ K + L LE+ EL + H D ++++ ++ E
Sbjct: 2656 EIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLL 2715
Query: 1226 -------------REKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQLKGEY 1272
REK LT++ E L ++ L + L L + +LK
Sbjct: 2716 DTNKQYEVEIQTYREK-LTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELK--- 2771
Query: 1273 EELHAHTKELKTSLNNAQLELNRWQARFDELKEQHQTMDISLTKLDNHCELLSRLKGNLE 1332
KT ++N + ++LK++++ + L C+ L K L+
Sbjct: 2772 ----------KTKMDNLKY--------VNQLKKENERAQGKMKLLIKSCKQLEEEKEILQ 2813
Query: 1333 EENHHLLSQIQLLSQQNQM----------LLEQNMENKEQYHEEQK---QYIDKLNALRR 1379
+E LSQ+Q ++ + L + E KE E+ K +Y+DK +L
Sbjct: 2814 KE----LSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLI 2869
Query: 1380 HKEKLEE 1386
EKLE+
Sbjct: 2870 SHEKLEK 2876
Score = 152 bits (383), Expect = 4e-36
Identities = 281/1283 (21%), Positives = 530/1283 (41%), Gaps = 231/1283 (18%)
Query: 247 EDKQHLAVELADTKARLRRVRQELEDKTEQLVDTRHEVDQLVL---ELQKVKQE-NIQLA 302
++KQ +L +A L++ +Q++E++ + + + E +L+ L+K KQ+ + +L
Sbjct: 32 KEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICESLEKTKQKISHELQ 91
Query: 303 ADARSARAYRDELDSLREKANRVERLELELTRCKEKLH---------DVD---------- 343
+L+S +++ +E+LE EL RCK +L DV
Sbjct: 92 VKESQVNFQEGQLNSGKKQ---IEKLEQELKRCKSELERSQQAAQSADVSLNPCNTPQKI 148
Query: 344 ----------FYKARMEELREDNIILIETKAMLEEQLTAARA--------------RGDK 379
+ ++ E+L+E +E + LE ++ A +A R
Sbjct: 149 FTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIA 208
Query: 380 VHEL---------EKENLQLKSKLHDLELDRDTDKKRI---EELLEENMVLEIAQKQS-- 425
H+ EK L S + RD +E+ L+I ++ +
Sbjct: 209 RHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANS 268
Query: 426 ----MNESAHLGWELEQL-SKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQ 480
+ S HL L+QL ++N +L + ++NE L+L+ + ++ +
Sbjct: 269 SFFDNSSSPHL---LDQLKAQNQELRN--------KINELE----LRLQGHEKEMKGQVN 313
Query: 481 GLRDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQ 540
++ L LE++ ++ E EK ++ ++ + Q ++ LE ++L +
Sbjct: 314 KFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSC 373
Query: 541 LQSDMETLKADKARQIKDLEQE-KDHLNRAMWSLRERSQ--VSSEARMKDVEKENKALHQ 597
+ + E+ + ++IK+ E+E ++ L+R S + Q + +AR+ ++ K +H
Sbjct: 374 QRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHN 433
Query: 598 TVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAE-----------KLERELQRLQEENGR 646
+ +L +L K+QL +LE+ K+K RAE +L R ++ +++EN
Sbjct: 434 VL---QAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNL 490
Query: 647 L-------ARKVTSLETATEKVEALEHESQGLQLENRTLRKSLDTL-----QNVSLQLEG 694
L AR+V LE + ++ ++SQ E + S +T+ + ++ Q
Sbjct: 491 LKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENS 550
Query: 695 LERDNKQLDAENLELRR--LVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGK 752
L + +L +LE +R + ++ + Q+ + + E+E + L ++L K +
Sbjct: 551 LTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYE 610
Query: 753 KSERLELSYQSVSAENLRLQQSLESSSHKTQTLESELGELEAERQALRRDLEALRLANAQ 812
+ + + + +EN +L +ES + + L+S++ LE L+ N +
Sbjct: 611 ELKEEKTLFSCWKSENEKLLTQMES---EKENLQSKINHLET---CLKTQQIKSHEYNER 664
Query: 813 LEGAEKDRKALEQEVAQLEK--DKKLLEKEAKRL-WQQVELKDAVLDDSTAKLSAVEKES 869
+ E DR+ L E+ L D K +E E ++L + +++ K D +K
Sbjct: 665 VRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSD---------QKHQ 715
Query: 870 RALDKELARCRDAAGKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELD 929
+ ++ + G++++LE + L+ ++ R L + E L+ S +
Sbjct: 716 KEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAE--YESLRDLLKSKDAS 773
Query: 930 KLSQELEKVGLNRELLLQEDDSGSDTKYKILEG--------RNESALKTTLAMKEEKIVL 981
++ E + R LL + + + G R+E L+ + K I+
Sbjct: 774 LVTNEDHQ----RSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAIL- 828
Query: 982 LEAQMEEKASLNRQLESELQM---LKKECETLRQNQGE-------GQHLQNSFKHPAGKT 1031
SL LES+ QM L+K+CE L Q +GE + + SF +
Sbjct: 829 ----QNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQR 884
Query: 1032 AASHQGKEAWGPGHKEATMELLRVKDRAIEL-----ERNNAALQAEKQ---LLKEQLQHL 1083
+ Q + T+ L K++ ++L E A +Q K+ LL++ L+ L
Sbjct: 885 ISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKEL 944
Query: 1084 ETQNVTFS------SQILTLQKQS-AFLQEHNTTLQTQTAKLQVENSTLSSQSAALTAQY 1136
+ + T S S I++L K+ L + N TL+ A L E L +S + A Y
Sbjct: 945 QLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESF-ANY 1003
Query: 1137 TLLQNHHTAKETENESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLK 1196
K S Q +QE+L LLQ E G +E S +Y+A ++S L+
Sbjct: 1004 I----DEREKSISELSDQYKQEKL-----ILLQRCEETGNAYEDLSQKYKAAQEKNSKLE 1054
Query: 1197 TL---------HRNLELEH--KELGERHGDMLKRKAELEEREKVLTTEREALQQEQRTNA 1245
L +R ELE + + H + L + A EER + L E E +QQ R+
Sbjct: 1055 CLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSE- 1113
Query: 1246 LAMGENQRLRGELDRVNFLHHQLKGEYEELHAHTKELKTSLNNAQLELNRWQARFDELKE 1305
M +NQ + K E L LK N Q E+N D L+E
Sbjct: 1114 --MTDNQ-------------NNSKSEAGGLKQEIMTLKEEQNKMQKEVN------DLLQE 1152
Query: 1306 QHQTMDISLTKLDNHCELLSRLKGNLEEEN-HHLLSQIQLLSQQNQMLLEQNMENKEQYH 1364
Q M + TK + C+ NLE E + + + + Q + ++E KE
Sbjct: 1153 NEQLMKVMKTK--HECQ-------NLESEPIRNSVKERESERNQCNFKPQMDLEVKEISL 1203
Query: 1365 EEQKQYIDKLNALRRHKE-KLEE 1386
+ + +L A+ R+KE KL+E
Sbjct: 1204 DSYNAQLVQLEAMLRNKELKLQE 1226
Score = 144 bits (364), Expect = 7e-34
Identities = 274/1329 (20%), Positives = 537/1329 (40%), Gaps = 194/1329 (14%)
Query: 208 ELIVDLTQERDYLQAQHPPSPIKSSSADSTPSPTSSLSSEDKQHLAVELADTKARLRRVR 267
E+ QE + + + P +P K SL +Q L +++
Sbjct: 1525 EVFCSSLQEENLTRKETPSAPAKGVEE------LESLCEVYRQSLEKLEEKMESQGIMKN 1578
Query: 268 QELEDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSARAYRDELDS-LREKANRVE 326
+E+++ + L R E+D L ++ EN Q S E++S L + + E
Sbjct: 1579 KEIQELEQLLSSERQELDCL---RKQYLSENEQWQQKLTSVTL---EMESKLAAEKKQTE 1632
Query: 327 RLELELTRCKEKLHDVDFYKARMEELREDNIILIETKAMLEEQLTAARARGDKVHELEKE 386
+L LEL + +L +D L +++ I+T+ ++ + + K H E
Sbjct: 1633 QLSLELEVARLQLQGLD--------LSSRSLLGIDTEDAIQGRNESCDI--SKEHTSETT 1682
Query: 387 NLQLKSKLHDL-ELDRDTDKKRIEELLEENMVLEIAQKQSMNESAHLGWELEQLSKNADL 445
K +H + + D D E + E ++ + S +S +E K
Sbjct: 1683 ERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGS 1742
Query: 446 SDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASL----VLEESGLKCGELEK 501
S+ + N L +++ +LQ ++ + +L V+E+ K L
Sbjct: 1743 SECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLN 1802
Query: 502 ENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSDMETLKADKARQIKDLEQ 561
E +L K+ + QL + ++ +LE + EL +E L +E D ++ +E
Sbjct: 1803 EMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVE- 1861
Query: 562 EKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEANGKLSQLEFEKRQ------ 615
+ LN + ++S S E +V K N + + + +LS++ EK
Sbjct: 1862 TSEGLNSDLEMHADKS--SREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEAL 1919
Query: 616 -LHRDLEQAKEKGERAEK-----------LERELQRLQEENGRL-------ARKVTSLET 656
L DLE + + EK LE EL + E +L ++K T+L+
Sbjct: 1920 YLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQ 1979
Query: 657 ATEKV-----EALEHESQGL---QLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLE 708
+EK+ E H+S+ L Q+ +++ + LQ +S + L +D L +
Sbjct: 1980 LSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQE---K 2036
Query: 709 LRRLVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAEN 768
L+ L + + S ++E + QL +EKE L K+SE L+ E
Sbjct: 2037 LQSLEKDSQALSLTKCELENQIAQLNKEKE----------LLVKESESLQARLSESDYEK 2086
Query: 769 LRLQQSLESSSHKTQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVA 828
L + ++LE++ + L + E LRR +E LR+ ++E EK + + +++
Sbjct: 2087 LNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRV---RIEADEKKQLHIAEKLK 2143
Query: 829 QLEKDKKLLEKEAKRLWQQVEL----KDAVLDDSTAKLSAVEKESRALDKELARCRDAAG 884
+ E++ L+ + + L +++++ ++ V+ D+ + VE +++ +
Sbjct: 2144 ERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFEL 2203
Query: 885 KLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKS--------------------QQL 924
L L + +LTKQ+ L+ L D +L KS + L
Sbjct: 2204 DLVTLRSEKENLTKQIQEKQGQLSEL--DKLLSSFKSLLEEKEQAEIQIKEESKTAVEML 2261
Query: 925 SSELDKLSQELEKVGLNRELLLQEDDSGSDTKYKILEGRNE-SALKTTLAMKEEKIVLLE 983
++L +L++ + + ++E++ + S + + RN L+ L E+K + +
Sbjct: 2262 QNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVL 2321
Query: 984 AQMEEKASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGP 1043
Q++E L+ ++ L++E E R NQ + K A +G
Sbjct: 2322 QQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLR 2381
Query: 1044 G-----------HKEATMELLRVKDRAIELERNNAAL-------QAEKQLLKEQ----LQ 1081
G + T EL + ++R ELE N++ + EK +KE+ ++
Sbjct: 2382 GLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAME 2441
Query: 1082 HLETQNVTFSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQN 1141
L+TQ + ++ L + L +Q L++E + L Y +LQ+
Sbjct: 2442 MLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQS 2501
Query: 1142 --HHTAKETEN--ESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKT 1197
+ +E E+ + L+++ E++ + + +QD E L + + E++ Q+ L+
Sbjct: 2502 SVNGLIQEVEDGKQKLEKKDEEI-SRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRN 2560
Query: 1198 LHRNLELEHKELGERHGDM-------------LKRKAELEEREKV--------LTTEREA 1236
L LE + + L ++ + L+ + EL + +K+ +T +
Sbjct: 2561 LTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETE 2620
Query: 1237 LQQE-----QRTNAL---AMGENQRLRGELDRVNFLHHQLKGEYEELHAHTKELKTSLN- 1287
LQ+E Q+T L GE RL GEL + K + +EL ELK SL+
Sbjct: 2621 LQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDC 2680
Query: 1288 ----------NAQLELNRWQARFDELKEQHQTMDISLT------------KLDNHCELLS 1325
+ E+ +Q R E +++HQ + + KL + E LS
Sbjct: 2681 MHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLS 2740
Query: 1326 R-------LKGNLEEENHHLLSQIQLLSQQNQMLLEQNMENKEQYHEEQKQYIDKLNALR 1378
LK + EE N+ L + Q+L + + ++ N++ Q +E ++ K+ L
Sbjct: 2741 SQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMD-NLKYVNQLKKENERAQGKMKLLI 2799
Query: 1379 RHKEKLEEK 1387
+ ++LEE+
Sbjct: 2800 KSCKQLEEE 2808
Score = 143 bits (361), Expect = 1e-33
Identities = 258/1149 (22%), Positives = 471/1149 (40%), Gaps = 150/1149 (13%)
Query: 184 ELEALSRSMVLHLRRLIDQRDECTEL--IV--------DLTQERDYLQAQHPPSPIKSSS 233
E++ L + L +L+ + + C EL IV DL+++ +Y H + +
Sbjct: 1803 EMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVET 1862
Query: 234 ADSTPSP----TSSLSSEDKQHLAVELADT-KARLRRVRQELEDKTEQLVDTRHEVDQLV 288
++ S S ED ++ D+ K R V EL + HE L
Sbjct: 1863 SEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLE 1922
Query: 289 LELQKVKQENIQLAADARSAR----AYRDELDSLREKANRVERLELELTRCKEKLHDVDF 344
+L+ V+ E + L D + + +EL + + N+ L EL +K +D
Sbjct: 1923 ADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQ---LRGELDTMSKKTTALDQ 1979
Query: 345 YKARMEELREDNIILIETKAMLEEQLTAARARGDKVHELEKENLQLKSKLHDLELDRDTD 404
+M+E + E ++ E L + +V E + L S + +L D+
Sbjct: 1980 LSEKMKEKTQ------ELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHL 2033
Query: 405 KKRIEELLEENMVLEIAQKQSMNESAHLGWELEQLSKNADLSDASRKSFVFELNECASSR 464
+++++ L +++ L + + + N+ A L E E L K ++ A
Sbjct: 2034 QEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQA---------------- 2077
Query: 465 ILKLEKENQSLQSTIQGLRDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSN 524
+L + + + + L A + E L+ ++E HQL + IEKL+ ++E +++
Sbjct: 2078 --RLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQ 2135
Query: 525 QDLETLSEELIREKEQLQSDMETLKAD-------KARQIKDLEQEKDHLNRAMWSLRE-- 575
+ +E RE + L+ +E L+ + + I D E K + + E
Sbjct: 2136 LHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMA 2195
Query: 576 RSQVSSEARMKDVEKENKALHQTVTEANGKLSQLE---FEKRQLHRDLEQA----KEKGE 628
RS E + + E + L + + E G+LS+L+ + L + EQA KE+ +
Sbjct: 2196 RSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESK 2255
Query: 629 RA-EKLERELQRLQEENGRLARKVTSLETATEKVEALEHESQGLQLENRTLRKSLDTLQN 687
A E L+ +L+ L E L ++ + ++ E L+ LR L+ +
Sbjct: 2256 TAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEK 2315
Query: 688 VSL----QLEGLERDNKQLDAENLELRRLVETMRFTSTKLAQMERENQ---------QLE 734
L QL+ E L L R +E R T+ + A +E EN ++E
Sbjct: 2316 KQLCVLQQLKESEHHADLLKGRVENLERELEIAR-TNQEHAALEAENSKGEVETLKAKIE 2374
Query: 735 REKEELR-----------KNVDLLKALGKKSERL-ELSYQSVSAENLRLQ------QSLE 776
+ LR + +L L K+ ER+ EL + S EN+ + Q E
Sbjct: 2375 GMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKE 2434
Query: 777 SSSHKTQTLESELGELEAERQALRRDLEALRL----ANAQLEGAEKDRKALEQEVAQLEK 832
SS + L+++L EL AL D EA + ++Q+E E ++ L Q + + +
Sbjct: 2435 KSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKN 2494
Query: 833 DKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKD 892
+ +L+ L Q+VE D KL ++E L ++ KL ++E +
Sbjct: 2495 NYIVLQSSVNGLIQEVE-------DGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGE 2547
Query: 893 NRDLTKQVTVHARTLTT-LREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDS 951
++ L K+ + R LT L + + + + K+ L L+ L + L EL L + D
Sbjct: 2548 HQ-LWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYK--NLENELELTKMD- 2603
Query: 952 GSDTKYKILEGRNESALKTTLAMKE-EKIVLLEAQMEEKASLNR-QLESELQMLKKECET 1009
K +E N+ K T +E ++ A+++E+ S + +L ELQ+L +E ++
Sbjct: 2604 ----KMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKS 2659
Query: 1010 ----LRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEATMELLRVKDRAIELERN 1065
L++ E L+ S K +GK + + K +A+ L+
Sbjct: 2660 SKDQLKELTLENSELKKSL-DCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLD-T 2717
Query: 1066 NAALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEHNTTLQTQT------AKLQ 1119
N + E Q +E+L E SSQ L + + +E N +L+ T K +
Sbjct: 2718 NKQYEVEIQTYREKLTSKEE---CLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTK 2774
Query: 1120 VEN----STLSSQSAALTAQYTLLQNHHTAKETENESLQRQQEQLTAAYEALLQDHEHLG 1175
++N + L ++ + LL E E E LQ++ QL AA Q+ + G
Sbjct: 2775 MDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAA-----QEKQKTG 2829
Query: 1176 TLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGE---RHGDMLKRKAELEEREKVLTT 1232
T+ + + E I K L LE + KE E ++ +L +LE+ +++L T
Sbjct: 2830 TVMDTKVDELTTEI------KELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLET 2883
Query: 1233 EREALQQEQ 1241
+ L +Q
Sbjct: 2884 QVAHLCSQQ 2892
Score = 130 bits (328), Expect = 1e-29
Identities = 252/1174 (21%), Positives = 511/1174 (43%), Gaps = 190/1174 (16%)
Query: 250 QHLAVELADTKARLRRVRQELEDKTEQLVDTRHEVDQLVLEL----QKVKQENIQLAADA 305
Q L ++L K L + L ++LV T + DQ + QK+K+ L+
Sbjct: 316 QELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQR 375
Query: 306 RSARAYRDELDS-LREKANRVERLELELTRCKEKLHDVDF----YKARM-EELREDNIIL 359
++A + R L+ ++EK + EL+R + +D KAR+ +EL++ +
Sbjct: 376 QNAESARCSLEQKIKEKEKEFQE---ELSRQQRSFQTLDQECIQMKARLTQELQQAKNMH 432
Query: 360 IETKAMLEEQLTAARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIEELLEENMVLE 419
+A L++ + + + + E +++ + + ++ + ++ +EE+ +EN +L+
Sbjct: 433 NVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLK 492
Query: 420 IAQKQSMNESAHLGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTI 479
+Q E HL EL+ + + + S ++F E+ +S+ E + LQ I
Sbjct: 493 SHSEQKAREVCHLEAELKNIKQCLNQS----QNFAEEMKAKNTSQ----ETMLRDLQEKI 544
Query: 480 QGLRDASLVLEESGLKCGELEKE---NHQLSKK----IEKLQTQLEREKQSNQDLETLSE 532
++ SL LE+ L +LEK+ + L KK IE+L +L + ++ ++ L + E
Sbjct: 545 -NQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALE 603
Query: 533 ELIREKEQLQSD---METLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVE 589
+E E+L+ + K++ + + +E EK++L + L E +K +
Sbjct: 604 LKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHL--------ETCLKTQQ 655
Query: 590 KENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGRLAR 649
++ ++ V L E R LH L+ + E + ELQ+ E + + +
Sbjct: 656 IKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQ 715
Query: 650 KVTS---LETA--TEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDA 704
K L+T+ T +VE LEH+ LQ +S ++ +R + L A
Sbjct: 716 KEIENMCLKTSQLTGQVEDLEHK-----------------LQLLSNEIMDKDRCYQDLHA 758
Query: 705 ENLELRRLVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGK-KSERLELSYQS 763
E LR L+++ + +R +++ +++ G SER E
Sbjct: 759 EYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSEC---- 814
Query: 764 VSAENLRLQQSLESSSHKTQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKAL 823
L QS ++S+ ++S LE+++Q + DL+ Q E + + +
Sbjct: 815 ----RLEADQSPKNSAILQNRVDSLEFSLESQKQ-MNSDLQ------KQCEELVQIKGEI 863
Query: 824 EQEVAQLEK-DKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDA 882
E+ + + E+ + + + ++R+ + E A + LSA+E + + L +
Sbjct: 864 EENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETE 923
Query: 883 AGKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSS----ELDKLSQE---L 935
+++EL+K N L + + L L E L LEK + + S E+++L+QE L
Sbjct: 924 QAEIQELKKSNHLLEDSL----KELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTL 979
Query: 936 EKV--GLNRELLLQEDDSGSDTKYKILEGRNESALKTTLAMKEEKIVLLE---------A 984
+++ LN+E + S S Y ++ R +S + + K+EK++LL+
Sbjct: 980 KEINASLNQEKMNLIQKSESFANY--IDEREKSISELSDQYKQEKLILLQRCEETGNAYE 1037
Query: 985 QMEEKASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGPG 1044
+ +K ++ S+L+ L EC +L +N+ +N + Q KEA+
Sbjct: 1038 DLSQKYKAAQEKNSKLECLLNECTSLCENR------KNELE----------QLKEAFAKE 1081
Query: 1045 HKEATMELLRVKDRAIELERNNAALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFL 1104
H+E +L ++R N L E + +++ L+ T N S + ++ L
Sbjct: 1082 HQEFLTKLAFAEER-------NQNLMLELETVQQALRSEMTDNQNNS------KSEAGGL 1128
Query: 1105 QEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETENESLQRQQEQLTAAY 1164
++ TL+ + K+Q E + L ++ L +++ H + E+E ++
Sbjct: 1129 KQEIMTLKEEQNKMQKEVNDLLQENEQL---MKVMKTKHECQNLESEPIR---------- 1175
Query: 1165 EALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAELE 1224
++ ER+S + + L+ +L+ + +L + + ++ +L+
Sbjct: 1176 ----------NSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQ 1225
Query: 1225 EREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQ---LKGEYE-ELHAHTK 1280
E EK E+E LQ E +T +RG+L+ N Q + G + E+ A K
Sbjct: 1226 ESEK----EKECLQHELQT----------IRGDLETSNLQDMQSQEISGLKDCEIDAEEK 1271
Query: 1281 ------ELKTSLN-NAQLELNRWQARFDELKEQHQTMDI-------SLTKL-DNHCELLS 1325
EL TS N NA L+ + Q ++L E + +I +T+L D+ E ++
Sbjct: 1272 YISGPHELSTSQNDNAHLQCS-LQTTMNKLNELEKICEILQAEKYELVTELNDSRSECIT 1330
Query: 1326 RLKGNLEEENHHLLSQIQLLSQQNQMLLEQNMEN 1359
+ + EE LL+++++L+ + +L + +E+
Sbjct: 1331 ATR-KMAEEVGKLLNEVKILNDDSGLLHGELVED 1363
Score = 128 bits (322), Expect = 5e-29
Identities = 225/1024 (21%), Positives = 428/1024 (41%), Gaps = 194/1024 (18%)
Query: 204 DECTELIVDLTQERDYLQAQ--HPPSPIKSSSADSTPSPTSSLSSEDKQHLAVELADTKA 261
D+ +E + + TQE + Q++ H ++ + T +LSS+ EL K
Sbjct: 1978 DQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTEL-LQTLSSD-----VSELLKDKT 2031
Query: 262 RLRRVRQELEDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSARAYRDELDSLREK 321
L+ Q LE ++ L T+ E++ + +L K K+ L ++ S +A E D EK
Sbjct: 2032 HLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKE---LLVKESESLQARLSESDY--EK 2086
Query: 322 ANRVERLE----------LELTRCKEKLHDVDFYKARMEELREDNIILIETKAMLEEQLT 371
N + LE L L+ +E++H + + +E+LR + +A ++QL
Sbjct: 2087 LNVSKALEAALVEKGEFALRLSSTQEEVHQL---RRGIEKLR------VRIEADEKKQLH 2137
Query: 372 AARARGDKVHELEKENLQLKSKLHDLELDR---------------------DTDKKRIEE 410
A +K+ E E+EN LK K+ +LE + +T K +IEE
Sbjct: 2138 IA----EKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEE 2193
Query: 411 LLEENMVLEIAQKQSMNESAHLGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEK 470
+ V E+ +E +L ++++ D SF L E + I E+
Sbjct: 2194 MARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEE 2253
Query: 471 EN---QSLQSTIQGLRDASLVLEESGLKCGELE-------------KENHQLSKKIEKLQ 514
+ LQ+ ++ L +A L CG+ E +E HQL IEKL+
Sbjct: 2254 SKTAVEMLQNQLKELNEAVAAL------CGDQEIMKATEQSLDPPIEEEHQLRNSIEKLR 2307
Query: 515 TQLER-EKQSNQDLETLSE-----ELIREK-EQLQSDMETLKADKARQIKDLEQEKDHLN 567
+LE EK+ L+ L E +L++ + E L+ ++E + ++ + E K +
Sbjct: 2308 ARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVE 2367
Query: 568 RAMWSLRERSQV--SSEARMKDVEKENKALHQTVTEANGKLSQLE-----FEKRQLHRDL 620
+ +Q E + + E + L + + ++S+LE FE ++
Sbjct: 2368 TLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQ 2427
Query: 621 EQAKEKGERAEKLERELQRLQEENGRLARKVTSLETATEKVEALEHESQGLQLENRTLRK 680
E+ + K + + +E +L+E N R+A E K + L + + L+LE L +
Sbjct: 2428 EKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQ 2487
Query: 681 SLDTLQNVSLQLEG--------LERDNKQLDAENLELRRL---VETMRFTSTKLAQMERE 729
LD +N + L+ +E ++L+ ++ E+ RL ++ +KL+Q+E E
Sbjct: 2488 GLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGE 2547
Query: 730 NQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSSHKTQTLESEL 789
+Q + + ELR + LE Q + ++N LQ +LE + LE+EL
Sbjct: 2548 HQLWKEQNLELRN----------LTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENEL 2597
Query: 790 GELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKD----KKLLEKEAKRLW 845
+ ++ + + + +L+ ++ + Q+ A+L+++ K L E + L
Sbjct: 2598 ELTKMDKMSFVEKVNKMTAKETELQ---REMHEMAQKTAELQEELSGEKNRLAGELQLLL 2654
Query: 846 QQV-----ELKDAVLDDSTAKLSA-------VEKESRALDKELA----RCRDAAGKLKEL 889
+++ +LK+ L++S K S VEKE + + E+A R +A K + L
Sbjct: 2655 EEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVRE-EIAEYQLRLHEAEKKHQAL 2713
Query: 890 EKD-NRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQE 948
D N+ ++ + LT+ E L +KL+ L S ++L+ L+ E L +
Sbjct: 2714 LLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKK- 2772
Query: 949 DDSGSDTKYKILEGRNESALKTTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLKKECE 1008
TK L+ N+ + A + K+++ +QLE E ++L+KE
Sbjct: 2773 ------TKMDNLKYVNQLKKENERAQGKMKLLIKSC---------KQLEEEKEILQKELS 2817
Query: 1009 TLRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEATMELLRVKDRAIELERNNAA 1068
L+ Q + K T+ +V + E++
Sbjct: 2818 QLQAAQEK----------------------------QKTGTVMDTKVDELTTEIKEL--- 2846
Query: 1069 LQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQ 1128
K+ L+E+ + + + S +++ +K L++ L+TQ A L + S S+
Sbjct: 2847 ----KETLEEKTKEADEYLDKYCSLLISHEK----LEKAKEMLETQVAHLCSQQSKQDSR 2898
Query: 1129 SAAL 1132
+ L
Sbjct: 2899 GSPL 2902
Score = 126 bits (317), Expect = 2e-28
Identities = 280/1344 (20%), Positives = 561/1344 (41%), Gaps = 205/1344 (15%)
Query: 47 LNQIMLQIDPRPTNQ-RINKHVNNDVNLRIQNLTILVRNIKTYYQEVLQQLIVMNLPNVL 105
L+Q +Q+ R T + + K+++N + + LT + + ++ +E Q+L
Sbjct: 410 LDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQA 469
Query: 106 MIGRDPLSGKSMEEIKKVLLLVLG---------CAVQCERK---------EEFIERIKQL 147
++ +SMEE+KK L+ C ++ E K + F E +K
Sbjct: 470 SQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAK 529
Query: 148 DIETQAGIVAHIQEVTHNQENVFDLQWLELPDVAPEELEALSRSMVLHLRRLIDQRDECT 207
+ +Q ++ +QE + QEN L+ L+L A +LE QRD C+
Sbjct: 530 NT-SQETMLRDLQEKINQQENSLTLEKLKL---AVADLE--------------KQRD-CS 570
Query: 208 ELIVDLTQERDYLQAQHPPSPIKSSSADSTPSPTSSLSSEDKQHLAVELADTKARLRRVR 267
+ DL ++R++ Q + T + +L S A+EL ++
Sbjct: 571 Q---DLLKKREHHIEQ------LNDKLSKTEKESKALLS------ALELK------KKEY 609
Query: 268 QELEDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSARAYRDELDSLREKANRVER 327
+EL+++ + E ++L+ +++ K EN+Q + ++ S E RV
Sbjct: 610 EELKEEKTLFSCWKSENEKLLTQMESEK-ENLQSKINHLETCLKTQQIKS-HEYNERVRT 667
Query: 328 LELELTRCKEKLHDVDFYKARMEELREDNIILIETKAMLEEQLTAARARGDKVHELEKEN 387
LE++ ++ + + + + + +ET+ + +L D+ H+ E EN
Sbjct: 668 LEMDRENLSVEIRN-------LHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIEN 720
Query: 388 LQLKSKLHDLELDRDTDKKRIEELLEENMVLEIAQKQSMNESAHLGWE-LEQLSKNADLS 446
+ LK+ +++ D + +LL EI K + H +E L L K+ D S
Sbjct: 721 MCLKTSQLTGQVE---DLEHKLQLLSN----EIMDKDRCYQDLHAEYESLRDLLKSKDAS 773
Query: 447 -----DASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASLVLEESGLKCGELEK 501
D R F+ + E S+ S E L+ + K
Sbjct: 774 LVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSE----------RSECRLEADQSPK 823
Query: 502 ENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSDMETLKADKARQ--IKDL 559
+ L +++ L+ LE +KQ N DL+ EEL++ K +++ ++ +KA++ Q + +
Sbjct: 824 NSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENL--MKAEQMHQSFVAET 881
Query: 560 EQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEANGKLSQLEFEKRQLHRD 619
Q L S + + + +++ EKE + L+ V ++ +L+ L
Sbjct: 882 SQRISKLQEDT-SAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDS 940
Query: 620 LEQAK--------EKGERAEKL---ERELQRLQEENGRLARKVTSLE----TATEKVEAL 664
L++ + EK E + + +RE++ L +ENG L SL +K E+
Sbjct: 941 LKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESF 1000
Query: 665 -----EHESQGLQLENRTLRKSLDTLQ---NVSLQLEGLERDNKQLDAENLELRRLV-ET 715
E E +L ++ ++ L LQ E L + K +N +L L+ E
Sbjct: 1001 ANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNEC 1060
Query: 716 MRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSL 775
+ ++E+ + +E +E + L ++++ L L ++V + LR + +
Sbjct: 1061 TSLCENRKNELEQLKEAFAKEHQEF---LTKLAFAEERNQNLMLELETVQ-QALRSEMTD 1116
Query: 776 ESSSHKTQT--LESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKD 833
++ K++ L+ E+ L+ E+ +++++ L N QL K + E LE +
Sbjct: 1117 NQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTK----HECQNLESE 1172
Query: 834 ---KKLLEKEAKR------LWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAG 884
+ E+E++R +E+K+ LD A+L V+ E+ +KEL
Sbjct: 1173 PIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQL--VQLEAMLRNKEL-------- 1222
Query: 885 KLKELEKDNRDLTKQVTVHARTLTTLREDLV---LEKLKSQQLSSELD-KLSQELEKVGL 940
KL+E EK+ L + L T+R DL L+ ++SQ++S D ++ E + +
Sbjct: 1223 KLQESEKEKECLQHE-------LQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISG 1275
Query: 941 NRELLLQEDDSG------SDTKYKILEGRNESALKTTLAMKEEKIVLLEAQMEEKASLNR 994
EL ++D+ T K+ E E + A K E + L E + R
Sbjct: 1276 PHELSTSQNDNAHLQCSLQTTMNKLNE--LEKICEILQAEKYELVTELNDSRSECITATR 1333
Query: 995 QLESELQMLKKECETLRQNQG--EGQHLQNSFKHPAGK--TAASHQGKEAWGPGHKEATM 1050
++ E+ L E + L + G G+ +++ P G+ + Q + P + +
Sbjct: 1334 KMAEEVGKLLNEVKILNDDSGLLHGELVEDI---PGGEFGEQPNEQHPVSLAPLDESNSY 1390
Query: 1051 ELLRVKDRAI-----ELERNNAALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQ 1105
E L + D+ + EL+ +LQ+E ++L +Q + ++ + + +L+ ++ L
Sbjct: 1391 EHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLS 1450
Query: 1106 EHNTTLQTQTAK---LQVENSTLSSQSAALTAQYTLLQN-------HHTAKETENESLQR 1155
+ Q K L +E + S S++ + L + ++T + SL
Sbjct: 1451 TNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLS 1510
Query: 1156 QQEQLTAAYEALLQD------HEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKEL 1209
E +A + + + E T E SA + + S + ++LE + +E
Sbjct: 1511 NLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLE-KLEEK 1569
Query: 1210 GERHGDMLKRKAELEEREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQLK 1269
E G M + E++E E++L++ER+ L ++ + EN++ + +L V +++
Sbjct: 1570 MESQGIM--KNKEIQELEQLLSSERQELDCLRKQ---YLSENEQWQQKLTSVTL---EME 1621
Query: 1270 GEYEELHAHTKELKTSLNNAQLEL 1293
+ T++L L A+L+L
Sbjct: 1622 SKLAAEKKQTEQLSLELEVARLQL 1645
Score = 109 bits (273), Expect = 2e-23
Identities = 200/954 (20%), Positives = 388/954 (40%), Gaps = 141/954 (14%)
Query: 519 REKQSNQDLETLSEELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQ 578
R Q Q+LE ++L +EK+Q Q +++L+A +Q + +E EK RE +
Sbjct: 15 RALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLK---RENQR 71
Query: 579 VSSEARMKDVEKENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQ 638
+ M+ E K + E K SQ+ F++ QL+ +Q EKLE+EL+
Sbjct: 72 L-----MEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQI-------EKLEQELK 119
Query: 639 RLQEENGRLARKVTSLETATEKVEALEH--ESQGLQLENRTLRKSLDTLQNVSLQLEGLE 696
R + E R + S + + + + + + K D + + ++E E
Sbjct: 120 RCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVE--E 177
Query: 697 RDNKQLDAENLELRRLVETMRFTSTKLAQMERENQ-------QLEREKEELRKNVDLLKA 749
R + + + L+ ++ +T+ + + R Q E+ L N
Sbjct: 178 RKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPI 237
Query: 750 LGKKSERLELSYQSVSAENLRLQ---QSLESSSHKTQTLESELGELEAERQALRRDLEAL 806
S Q V+ LQ + SS + L +L+A+ Q LR + L
Sbjct: 238 RRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINEL 297
Query: 807 RLANAQLEGAEKDRKA----LEQEVAQLEKDK-KLLEKEA--KRLWQQVELKDAVLDDST 859
L +L+G EK+ K ++ QLEK K +L+EKE + ++ A D ++
Sbjct: 298 EL---RLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQAS 354
Query: 860 AKLSAVEKESRALDKEL---------ARCRDAAGKLKELEKDNRDLTKQVTVHARTLTTL 910
K +A+E++ + L ++L ARC K+KE EK+ ++ +++ R+ TL
Sbjct: 355 TKYTALEQKLKKLTEDLSCQRQNAESARC-SLEQKIKEKEKEFQE---ELSRQQRSFQTL 410
Query: 911 REDLVLEKLKSQQ-----------LSSELDKLSQELEKVGLNRELLLQEDDSGSDTKYKI 959
++ + K + Q L +ELDKL+ +++ N E Q+ ++ ++
Sbjct: 411 DQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKL-CRAEQAFQA 469
Query: 960 LEGRNESALKTTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLKKECETLRQNQGEGQH 1019
+ + ++ MK+E LL++ E+KA LE+EL+ +K +C QN E
Sbjct: 470 SQIKENELRRSMEEMKKENN-LLKSHSEQKAREVCHLEAELKNIK-QCLNQSQNFAEEMK 527
Query: 1020 LQNSFKHPAGKTAASHQGKE-------------AWGPGHKEATMELLRVKDRAIE----- 1061
+N+ + + ++ A ++ + +LL+ ++ IE
Sbjct: 528 AKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDK 587
Query: 1062 ---LERNNAALQAEKQLLKEQLQHLETQNVTFS------SQILT-LQKQSAFLQEH---- 1107
E+ + AL + +L K++ + L+ + FS ++LT ++ + LQ
Sbjct: 588 LSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHL 647
Query: 1108 NTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETENESLQRQQEQLTAAYEAL 1167
T L+TQ K N + + ++N H ++++ ++ Q+ AY L
Sbjct: 648 ETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQK----LAYMEL 703
Query: 1168 LQDHEHLGTLHERQSAEYEALIRQHSCLKT---------LHRNLELEHKELGERHGDMLK 1218
Q E H+++ ++ CLKT L L+L E+ ++
Sbjct: 704 QQKAEFSDQKHQKEI--------ENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQD 755
Query: 1219 RKAELEEREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQLK---GEYEEL 1275
AE E +L ++ +L + ++QR D+ +HH GE +
Sbjct: 756 LHAEYESLRDLLKSKDASLVTNE--------DHQRSLLAFDQQPAMHHSFANIIGEQGSM 807
Query: 1276 HAHTKELKTSLNNAQLELNRWQARFDELKEQHQTMDISLTKLDNHCELLSRLKGNLEEEN 1335
+ E + + + Q R D L+ ++ + L CE L ++KG +EE
Sbjct: 808 PSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEE-- 865
Query: 1336 HHLLSQIQLLSQQNQMLLEQNMENKEQYHEE----QKQYIDKLNALRRHKEKLE 1385
+ Q +Q + + + + E+ Q + L+AL +++L+
Sbjct: 866 -----NLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQ 914
Score = 103 bits (256), Expect = 2e-21
Identities = 289/1411 (20%), Positives = 538/1411 (38%), Gaps = 211/1411 (14%)
Query: 164 HNQENVFDLQWLELPDVAPEELEALSRSMVLHLRRLIDQRDECTELIV----DLTQERDY 219
+ QE + LQ E A E+L ++ +L +ECT L +L Q ++
Sbjct: 1018 YKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEA 1077
Query: 220 LQAQHPPSPIKSSSADSTPSPTSSLSSEDKQHLAVELADTKARLRRVRQELEDKTEQLVD 279
+H K + A+ E Q+L +EL + LR + T+ +
Sbjct: 1078 FAKEHQEFLTKLAFAE-----------ERNQNLMLELETVQQALR------SEMTDNQNN 1120
Query: 280 TRHEVDQLVLELQKVKQENIQLAADARSARAYRDELDSLREKANRVERLELELTRCKEKL 339
++ E L E+ +K+E ++ + ++L + + + + LE E R K
Sbjct: 1121 SKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKE 1180
Query: 340 HDVDFYKARME---ELREDNIILIETKAMLEEQLTAARARGDKVHELEKENLQLKSKLHD 396
+ + + + +L I L A L + R + K+ E EKE L+ +L
Sbjct: 1181 RESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQT 1240
Query: 397 LELDRDTDKKRIEELLE----ENMVLEIAQKQ---------SMNESAHLGWELE------ 437
+ D +T + + E ++ ++ +K S N++AHL L+
Sbjct: 1241 IRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKL 1300
Query: 438 -QLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASLVLEESGLKC 496
+L K ++ A + V ELN+ S I K + + L + ++ ++SGL
Sbjct: 1301 NELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKL---LNEVKILNDDSGLLH 1357
Query: 497 GELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSDMETLKADKARQI 556
GEL +E + E+ Q + D++
Sbjct: 1358 GEL---------------------------VEDIPGGEFGEQPNEQHPVSLAPLDESNSY 1390
Query: 557 KDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEANGKLSQLEFEKRQL 616
+ L + L+E+ ++ E+K LH + + K+S+L+ L
Sbjct: 1391 EHLTLSDKEVQMHFAELQEK--------FLSLQSEHKILHDQHCQMSSKMSELQTYVDSL 1442
Query: 617 HRD-LEQAKEKGERAEKLERELQRLQEENGRLARKVTSLETATEKVEALEHESQGLQLEN 675
+ L + L +E+Q L E G + +S + + +L S L
Sbjct: 1443 KAENLVLSTNLRNFQGDLVKEMQ-LGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLE 1501
Query: 676 RTLRKSL---------------DTLQNVSLQLEGLER-DNKQLDAENLE-LRRLVETMRF 718
+T SL D + SLQ E L R + A+ +E L L E R
Sbjct: 1502 QTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQ 1561
Query: 719 TSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESS 778
+ KL + + E+Q + + KE +L + L + + L+ + +EN + QQ L S
Sbjct: 1562 SLEKLEE-KMESQGIMKNKEIQ----ELEQLLSSERQELDCLRKQYLSENEQWQQKLTSV 1616
Query: 779 SHKTQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKAL-----------EQEV 827
T +ES+L + + + L +LE RL QL+G + ++L E
Sbjct: 1617 ---TLEMESKLAAEKKQTEQLSLELEVARL---QLQGLDLSSRSLLGIDTEDAIQGRNES 1670
Query: 828 AQLEKD--KKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGK 885
+ K+ + E+ K Q+ KDA D L + K C
Sbjct: 1671 CDISKEHTSETTERTPKHDVHQICDKDAQQD---LNLDIEKITETGAVKPTGECSGEQSP 1727
Query: 886 LKELEKDNRDLTKQVTVHARTLTTL-------------REDLVLEKLKSQQLSSELDKLS 932
E D T+ + L+ +ED+ +L+ ++ S+E +L
Sbjct: 1728 DTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLL 1787
Query: 933 QELEKVGLNRELLLQEDDSGSDTKYKILEGRNESALKTTLAMKEEKIVLLEAQMEEKASL 992
+E E LL E D+K + E L K E + LE + E
Sbjct: 1788 HVIEDRDRKVESLLNEMKE-LDSKLHLQE--------VQLMTKIEACIELEKIVGELKKE 1838
Query: 993 NRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTAASHQG------KEAWGPGHK 1046
N L +L+ + + L Q + L + + A K++ G ++W
Sbjct: 1839 NSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFL 1898
Query: 1047 EATMELLRVKDRAIELERNNAALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQE 1106
+ EL R++ +E L+A+ ++++ + LE N QK L+E
Sbjct: 1899 DVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNEN-------KQKVIVCLEE 1951
Query: 1107 HNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETENESLQRQQEQLTAAYEA 1166
+ + ++ +L+ E T+S ++ AL L K E ES Q + EA
Sbjct: 1952 ELSVVTSERNQLRGELDTMSKKTTALDQ----LSEKMKEKTQELESHQSECLHCIQVAEA 2007
Query: 1167 LLQDH-EHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAELEE 1225
+++ E L TL S++ L++ + L+ ++LE + + L ++ + A+L +
Sbjct: 2008 EVKEKTELLQTL----SSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNK 2063
Query: 1226 REKVLTTEREALQQE-----------QRTNALAMGENQRLRGELDRVNFLHHQLKGEYEE 1274
+++L E E+LQ + A+ E L HQL+ E+
Sbjct: 2064 EKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEK 2123
Query: 1275 LHAHTK-ELKTSLNNAQLELNRWQARFDELKEQHQTMDISLTKLDNHCELLSRLKGNLEE 1333
L + + K L+ A+ +L + D LK++ + ++ L + + EL+ N +
Sbjct: 2124 LRVRIEADEKKQLHIAE-KLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKA 2182
Query: 1334 ENHHLLSQIQLLSQQ------NQMLLEQNMEN-KEQYHEEQKQY--IDKL----NALRRH 1380
E L +QI+ +++ + + L EN +Q E+Q Q +DKL +L
Sbjct: 2183 EVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEE 2242
Query: 1381 KEKLEEKIMDQYK----FYDPPPKKKNHWIGA--------KALVKLIKPKKEGSRERLKS 1428
KE+ E +I ++ K K+ N + A KA + + P E +L++
Sbjct: 2243 KEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIE-EEHQLRN 2301
Query: 1429 TVDSPPWQLESSDPASPAASQPLRSQAENPD 1459
+++ +LE+ + Q L+ + D
Sbjct: 2302 SIEKLRARLEADEKKQLCVLQQLKESEHHAD 2332
Score = 102 bits (253), Expect = 5e-21
Identities = 279/1341 (20%), Positives = 511/1341 (38%), Gaps = 235/1341 (17%)
Query: 184 ELEALSRSMVLHLRRLIDQRDEC-TELIVDLTQERDYLQAQHPPSPIKSSSADSTPSPTS 242
++E L + L ++D +D C +L + RD L++ K +S +
Sbjct: 731 QVEDLEHKLQLLSNEIMD-KDRCYQDLHAEYESLRDLLKS-------KDASLVTNEDHQR 782
Query: 243 SLSSEDKQ--------HLAVELADTKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQKV 294
SL + D+Q ++ E + R E + + ++ VD L L+
Sbjct: 783 SLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQ 842
Query: 295 KQENIQLAADARSARAYRDELDSLREKANRVERLELELTRCKEKLHDVDFYKARMEELRE 354
KQ N L + E++ KA ++ + + T R+ +L+E
Sbjct: 843 KQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAET------------SQRISKLQE 890
Query: 355 DNI----ILIETKAMLEEQLTAARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIEE 410
D ++ ET + LE + + DKV + E +LK H LE D + +
Sbjct: 891 DTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLE-----DSLKELQ 945
Query: 411 LLEENMVLEIAQKQSMNESAHLGW-ELEQLSK-NADLSD--ASRKSFVFELNECASSRIL 466
LL E + LE K+ M+ L E+E+L++ N L + AS L + + S
Sbjct: 946 LLSETLSLE---KKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFAN 1002
Query: 467 KLEKENQSLQSTIQGLRDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQD 526
+++ +S+ + L+L + +C E LS+K + Q + N
Sbjct: 1003 YIDEREKSISELSDQYKQEKLILLQ---RCEETGNAYEDLSQKYKAAQ-------EKNSK 1052
Query: 527 LETLSEELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMK 586
LE L E E ++++E LK A++ ++ L + ++ ER+Q M
Sbjct: 1053 LECLLNECTSLCENRKNELEQLKEAFAKE------HQEFLTKLAFA-EERNQ----NLML 1101
Query: 587 DVEKENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGR 646
++E +AL +T+ Q K E A L++E+ L+EE +
Sbjct: 1102 ELETVQQALRSEMTD-------------------NQNNSKSE-AGGLKQEIMTLKEEQNK 1141
Query: 647 LARKVTSLETATE---KVEALEHESQGLQLE---NRTLRKSLDTLQ-NVSLQLEGLERDN 699
+ ++V L E KV +HE Q L+ E N + + Q N Q++ LE
Sbjct: 1142 MQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMD-LEVKE 1200
Query: 700 KQLDAENLELRRLVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLE- 758
LD+ N +L +L +R KL + E+E + L+ E + +R +++ +S+ +
Sbjct: 1201 ISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISG 1260
Query: 759 LSYQSVSAE----------------NLRLQQSLESSSHKTQTLESELGELEAERQALRRD 802
L + AE N LQ SL+++ +K LE L+AE+ L +
Sbjct: 1261 LKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTE 1320
Query: 803 LEALR--LANAQLEGAEKDRKALEQEVAQLEKDKKLLEKE----------AKRLWQQVEL 850
L R A + AE+ K L EV L D LL E ++ +Q +
Sbjct: 1321 LNDSRSECITATRKMAEEVGKLL-NEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPV 1379
Query: 851 KDAVLDDSTA--KLSAVEKESRALDKEL----------------ARCRDAAGKLKELEKD 892
A LD+S + L+ +KE + EL C+ + K+ EL+
Sbjct: 1380 SLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQ-MSSKMSELQTY 1438
Query: 893 NRDLTKQVTVHARTLTTLREDLV------LEKLKSQQLSSELDKLSQELEKVG---LNRE 943
L + V + L + DLV LE+ LSS S L +G R
Sbjct: 1439 VDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRA 1498
Query: 944 LLLQEDDSGSDTKYKILEGRNESALKTTL--AMKEEKIV-----------------LLEA 984
LL Q D + + N+ ++ +++EE + L E
Sbjct: 1499 LLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEV 1558
Query: 985 QMEEKASLNRQLESELQMLKKECETLRQ-NQGEGQHLQNSFKHPAGKTAASHQGKEAWGP 1043
+ L ++ES+ M KE + L Q E Q L K + E W
Sbjct: 1559 YRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSE-------NEQW-- 1609
Query: 1044 GHKEATMELLRVKDRAIELERNNAALQAEKQLLKEQLQHLETQN-----VTFSSQILTLQ 1098
++ T L ++ + ++ L E ++ + QLQ L+ + + I
Sbjct: 1610 -QQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRN 1668
Query: 1099 KQSAFLQEHNTTLQTQTAK----------------LQVENSTLS---SQSAALTAQYTLL 1139
+ +EH + +T K L +E T + + + + +
Sbjct: 1669 ESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPD 1728
Query: 1140 QNHHTAKETENESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLH 1199
N+ E + + +L+ + L + LG + + + + L+ LH
Sbjct: 1729 TNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLH 1788
Query: 1200 RNLELEHKELGERHGDMLKRKAELEEREKVLTTEREALQQEQRTNALAMGENQRLRGELD 1259
+E +++ +M + ++L +E L T+ EA + ++ EN L +L+
Sbjct: 1789 -VIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLE 1847
Query: 1260 RVNFLHHQLKGEYE---------ELHAHTKELKTSLNNAQLELNRWQARFDELKEQHQTM 1310
+ H +L E E+HA + +N + W+ RF +
Sbjct: 1848 YFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERF---------L 1898
Query: 1311 DISLTKLDNHCELLSRLKGNLEEENHHLLSQIQLLSQQNQMLLEQNMENKEQ----YHEE 1366
D+ +N + K ++E E +L + ++++ Q ++ LE++ ENK++ EE
Sbjct: 1899 DV-----ENELSRIRSEKASIEHEALYLEADLEVV-QTEKLCLEKDNENKQKVIVCLEEE 1952
Query: 1367 QKQYIDKLNALRRHKEKLEEK 1387
+ N LR + + +K
Sbjct: 1953 LSVVTSERNQLRGELDTMSKK 1973
>gi|14165274 golgi-associated microtubule-binding protein HOOK3
[Homo sapiens]
Length = 718
Score = 174 bits (440), Expect = 1e-42
Identities = 169/690 (24%), Positives = 326/690 (47%), Gaps = 86/690 (12%)
Query: 4 TVSELLELFLQSPLVTWVKTFGPFGSGSQDNLTMYMDLVDGIFLNQIMLQIDPRPTNQ-- 61
+V L L L+TW++TF DL +G+ + Q++ +IDP ++
Sbjct: 3 SVESLERAELCESLLTWIQTFNVDAP-----CQTVEDLTNGVVMAQVLQKIDPAYFDENW 57
Query: 62 --RINKHVNNDVNLRIQNLTILVRNIKTYYQEVL-QQLIVMNLPNVLMIGRDPLSGKSME 118
RI V ++ L+I NL +++ I Y E+L QQ+ LP+V +IG
Sbjct: 58 LNRIKTEVGDNWRLKISNLKKILKGILDYNHEILGQQINDFTLPDVNLIGEH----SDAA 113
Query: 119 EIKKVLLLVLGCAVQCERKEEFIERIKQLDIETQAGIVAHIQEVTHNQENVF--DLQWLE 176
E+ ++L L+LGCAV CE+K+E+I+ I ++ Q ++ IQE+ + V + +++
Sbjct: 114 ELGRMLQLILGCAVNCEQKQEYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVD 173
Query: 177 LPDVAPEELEALSRSMVLHLRRLIDQRDECTEL---IVDLTQERDYLQAQHPPSPIKSSS 233
L + E L+ + L + I QR C EL + L +E+ L A++ + +
Sbjct: 174 LDRQLKKTTEELNEA--LSAKEEIAQR--CHELDMQVAALQEEKSSLLAENQVLMERLNQ 229
Query: 234 ADSTPSPTSSLSSEDKQHLAVELADTKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQK 293
+DS P S ++HL ++ +L ++++E D R ++L E+ +
Sbjct: 230 SDSIEDPNSPAG---RRHLQLQ-----TQLEQLQEETFRLEAAKDDYRIRCEELEKEISE 281
Query: 294 VKQENIQLAADARSARAYRDELDSLREKANRVERLELELTRCKEKLHDVDFYKARMEELR 353
++Q+N +L A A++ +DE+D LR +++V +LE ++ K+KL D+ + +++ L
Sbjct: 282 LRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLE 341
Query: 354 EDNIILIETKAMLEEQLTAARA---------------------RGDKVHELEKENLQLKS 392
E N + ++ LEE+L A A K +L+ E +LK
Sbjct: 342 EKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKE 401
Query: 393 KLHDLELDRD---TDKKRIEELLEENMVLEIAQKQSMNESAHLGWELEQLSKNADLSDAS 449
K+ L+ ++D T++ ++E +EE ++ + Q + L L +
Sbjct: 402 KVDSLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQG------LMPLGSQESSDSLA 455
Query: 450 RKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASL-----VLEESGLKCGELEKENH 504
+ E+ E ++++L+ EN+ L+ +G + + +L+++ L+ ELE EN
Sbjct: 456 AEIVTPEIRE----KLIRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELETENR 511
Query: 505 QLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSDMETLK------ADKARQIKD 558
+++++ ++Q+Q+E ++S QD + +E+ + K++L+ +E L K I+D
Sbjct: 512 LVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIED 571
Query: 559 LEQ-------EKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEAN-GKLSQLE 610
LE + + L A+ E + E K +EK + + N G +++
Sbjct: 572 LEPRFNNSSLKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQ 631
Query: 611 FEKRQL-HRD-LEQAKEKGERAEKLERELQ 638
K QL RD L + EK K +RE++
Sbjct: 632 ALKNQLQERDRLFHSLEKEYEKTKSQREME 661
Score = 91.7 bits (226), Expect = 7e-18
Identities = 118/516 (22%), Positives = 230/516 (44%), Gaps = 53/516 (10%)
Query: 359 LIETKAMLEEQLTAARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIEELLEENMVL 418
L +T L E L+A + HEL+ + L+ + L + + E L ++ +
Sbjct: 178 LKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQV----LMERLNQSDSI 233
Query: 419 EIAQKQSMNESAHLGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQST 478
E + L +LEQL + +A++ + E I +L ++N L +
Sbjct: 234 EDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEEL-EKEISELRQQNDELTTL 292
Query: 479 I---QGLRDASLVLEESGLKCGELEKENHQLSKKIEKL-----QTQLEREKQSNQDLETL 530
Q L+D VL S K +LE + KK+E L Q +L EK + T+
Sbjct: 293 ADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTV 352
Query: 531 S-EELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKD-V 588
S EE +R+ +S +ET K RQ+ +L+ +++S E++ D +
Sbjct: 353 SLEEELRKANAARSQLETYK----RQVVELQ----------------NRLSEESKKADKL 392
Query: 589 EKENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAK-EKGERAEKLERELQRL--QEENG 645
+ E K L + V + +L E+ L +E+ + + + + + L L QE +
Sbjct: 393 DFEYKRLKEKVDSLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSD 452
Query: 646 RLARKVTSLETATEKVEALEHESQGLQL-----ENRTLRKSLDTLQNVSLQLEGLERDNK 700
LA ++ + E EK+ L+HE++ L+L +N + L + +L+ LE +N+
Sbjct: 453 SLAAEIVTPEIR-EKLIRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELETENR 511
Query: 701 QLDAENLELRRLVETMRFTSTKLAQMERENQQLEREKEE-LRKNVDLLKALGKKS---ER 756
++ LE++ VE ++ + ++ L+++ EE L K + L KK E
Sbjct: 512 LVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIED 571
Query: 757 LELSYQSVSAENLRLQQSLESSSHKTQTLESELGELEAERQALRRDLEALRLANAQLEGA 816
LE + + S + LQ++L + + +E + + +++ R L+ Q +GA
Sbjct: 572 LEPRFNNSSLKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDP-----KQNQGA 626
Query: 817 EKDRKALEQEVAQLEKDKKLLEKEAKRLWQQVELKD 852
+ +AL+ ++ + ++ LEKE ++ Q E+++
Sbjct: 627 APEIQALKNQLQERDRLFHSLEKEYEKTKSQREMEE 662
Score = 87.4 bits (215), Expect = 1e-16
Identities = 121/536 (22%), Positives = 237/536 (44%), Gaps = 88/536 (16%)
Query: 447 DASRKSFVFELNECASS------RILKLEKENQSLQSTIQGLRDASLVLEESGLKCGELE 500
D K ELNE S+ R +L+ + +LQ L + VL E + +E
Sbjct: 175 DRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSDSIE 234
Query: 501 KENHQLSKKIEKLQTQLEREKQSNQDLETLS-------EELIREKEQL--QSDMETLKAD 551
N ++ +LQTQLE+ ++ LE EEL +E +L Q+D T AD
Sbjct: 235 DPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLAD 294
Query: 552 KARQIKD----LEQEKDHLNRA---MWSLRERSQVSSEAR--MKDVEKENK-------AL 595
+A+ +KD L D +++ + S +++ + + R +K +E++N +L
Sbjct: 295 EAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSL 354
Query: 596 HQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGRLARKVTSLE 655
+ + +AN SQLE KRQ+ + E+ ++A+KL+ E +RL+
Sbjct: 355 EEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLK-------------- 400
Query: 656 TATEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQ-----LEGLERDNKQLDAENLELR 710
EKV++L+ E L+ E +L+++++ L+ V Q +GL Q +++L
Sbjct: 401 ---EKVDSLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAE 457
Query: 711 RLVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLR 770
+ +R KL +++ EN+ L+ +E G +E++ L + NLR
Sbjct: 458 IVTPEIR---EKLIRLQHENKMLKLNQE------------GSDNEKIALLQSLLDDANLR 502
Query: 771 LQQSLESSSHKTQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQL 830
+ LE+ + + + L E++++ + L++ L+ ++ E + +K LE+ + +L
Sbjct: 503 -KNELET---ENRLVNQRLLEVQSQVEELQKSLQD---QGSKAEDSVLLKKKLEEHLEKL 555
Query: 831 EKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELE 890
+ L+K K A+++D + + + L + L + + +++E
Sbjct: 556 HEANNELQK-----------KRAIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQMEERY 604
Query: 891 KDNRDLTKQV--TVHARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNREL 944
K + K V T+ + ++ K + Q+ L +E EK RE+
Sbjct: 605 KKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRLFHSLEKEYEKTKSQREM 660
Score = 65.5 bits (158), Expect = 5e-10
Identities = 115/512 (22%), Positives = 208/512 (40%), Gaps = 44/512 (8%)
Query: 895 DLTKQVTVHARTLTTLREDLVLEKLKSQ---QLSSELDKLSQELEKVGLNRELLLQE-DD 950
DL +Q+ +T L E L ++ +Q +L ++ L +E + ++L++ +
Sbjct: 173 DLDRQLK---KTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQ 229
Query: 951 SGSDTKYKILEGRNESALKTTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLKKECETL 1010
S S GR L+T L +E+ LEA ++ +LE E+ L+++ + L
Sbjct: 230 SDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDEL 289
Query: 1011 RQNQGEGQHLQNS---FKHPAGKTAASHQGKEAWGPGHKEATMELLRVKDRAIELERNNA 1067
E Q L++ +H + K + E+ +K+ +L ++ + LE N
Sbjct: 290 TTLADEAQSLKDEIDVLRHSSDKVSKLEGQVES----YKKKLEDLGDLRRQVKLLEEKNT 345
Query: 1068 ALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLSS 1127
L+E+L+ SQ+ T ++Q LQ + + KL E L
Sbjct: 346 MYMQNTVSLEEELRKANAAR----SQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKE 401
Query: 1128 QSAALTAQYTLLQNHH-TAKET--ENESLQRQQEQLTAAYEALLQDHEHLGTL-HERQSA 1183
+ +L + L+ + KET E +Q Q+ QLT L E +L E +
Sbjct: 402 KVDSLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTP 461
Query: 1184 EY-EALIRQHSCLKTLHRNLELEHKE----LGERHGDMLKRKAELEEREKVLT------- 1231
E E LIR K L N E E L D RK ELE +++
Sbjct: 462 EIREKLIRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQ 521
Query: 1232 TEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQLKGEYEELHAHTKELKTSLNNAQL 1291
++ E LQ+ + ++ L+ +L+ H+ E ++ A ++L+ NN+ L
Sbjct: 522 SQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSL 581
Query: 1292 ELNRWQARFDELKEQHQTMDISLTKLDNHCELLSRLKGNLEEENHHLLSQIQLLSQQNQM 1351
++ Q + +E+ + M+ K + + R ++N +IQ L Q Q
Sbjct: 582 KIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLD--PKQNQGAAPEIQALKNQLQ- 638
Query: 1352 LLEQNMENKEQYHEEQKQYIDKLNALRRHKEK 1383
E +H +K+Y +K + R +EK
Sbjct: 639 ------ERDRLFHSLEKEY-EKTKSQREMEEK 663
Score = 51.6 bits (122), Expect = 8e-06
Identities = 63/291 (21%), Positives = 129/291 (44%), Gaps = 37/291 (12%)
Query: 1201 NLELEHKELGERHGDMLKRKAELEEREKVLTTEREALQQEQRTNALAMGENQRLRGELDR 1260
+L+ + K+ E + L K E+ +R L + ALQ+E+ + + ENQ L L++
Sbjct: 173 DLDRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSS---LLAENQVLMERLNQ 229
Query: 1261 VNFL----------HHQLKGEYEELHAHTKELKTSLNNAQLELNRWQARFDELKEQH--- 1307
+ + H QL+ + E+L T L+ + ++ ++ + EL++Q+
Sbjct: 230 SDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDEL 289
Query: 1308 -------QTMDISLTKLDNHCELLSRLKGNLE------EENHHLLSQIQLLSQQNQMLLE 1354
Q++ + L + + +S+L+G +E E+ L Q++LL ++N M +
Sbjct: 290 TTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYM- 348
Query: 1355 QNMENKEQYHEEQKQYIDKLNALRRHKEKLEEKIMDQYKFYDPPPKKKNHWIGAKALVKL 1414
QN + E+ + +L +R +L+ ++ ++ K D K + K V
Sbjct: 349 QNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKAD---KLDFEYKRLKEKVDS 405
Query: 1415 IKPKKE---GSRERLKSTVDSPPWQLESSDPASPAASQPLRSQAENPDTPA 1462
++ +K+ R+ LK T++ + PL SQ E+ D+ A
Sbjct: 406 LQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQ-ESSDSLA 455
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 171 bits (432), Expect = 9e-42
Identities = 287/1348 (21%), Positives = 575/1348 (42%), Gaps = 179/1348 (13%)
Query: 247 EDKQHLAVEL-------ADTKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQKVKQENI 299
E HL +L A+ +A LR +++E E+ ++L ++RH+ + +L+++ QE
Sbjct: 659 EKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAK 718
Query: 300 QLAADARSARAYRDELDSLREKAN---RVERLELELTRCKEKLHDVDFYKARME----EL 352
+ + ARA +++ +REKA R++ +E + E+L + K +E E
Sbjct: 719 R--QEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEA 776
Query: 353 REDNIILIETKAMLEEQL-TAARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIEEL 411
++ N ++ TK LE Q+ T +A+ E+ L+L ++ E +RD +++ +
Sbjct: 777 QQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQA 836
Query: 412 LEENMVLEIAQKQSMNESAHL---------GWELEQLSKNADLSDASRKSFVFELNEC-- 460
+E QK + + + W ++L+K + + + L E
Sbjct: 837 EQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQT 896
Query: 461 ---------------ASSRI----LKLEKENQSLQSTI----QGLRDASLVLEE--SGLK 495
A S + L+ EKE SL T+ + L DAS LE +K
Sbjct: 897 EMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMK 956
Query: 496 CGELEKENHQ--LSKKIEKLQTQL-EREKQSNQDLETLSEE---LIREKEQLQSDMETLK 549
+L+++ L ++++ Q +L E +Q DL L EE L+++K LQ +E LK
Sbjct: 957 VQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLK 1016
Query: 550 A-----------------DKARQI-------KDLEQEKDHLNRAMWSLRERSQVSSEARM 585
+ +K R+ K+LE+EK L ++ +R V EA
Sbjct: 1017 SQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADS 1076
Query: 586 KDVEKENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAK-----------EKGERAEKLE 634
++E AL Q + EA G+ +L + L +++++ + E+ E + E
Sbjct: 1077 IR-QQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITE 1135
Query: 635 RELQR-LQEENGRLARKVTSLETATEKVEALEHESQ-GLQLENRTLRKSLDTLQNVSL-- 690
++L+ L + + A+ L + ++EAL E Q G Q + + SL + +L
Sbjct: 1136 QQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGS 1195
Query: 691 ----------------QLEGLERDNKQLDAENLELRRLVETMRFTSTKLAQMERENQQLE 734
+ GLE D Q A +L R + T + + + +Q L
Sbjct: 1196 VCESRPELSGGGDSAPSVWGLEPD--QNGARSLFKRGPLLTALSAEAVASALHKLHQDLW 1253
Query: 735 REKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSSHKTQTLESELGELEA 794
+ ++ D ++ L ++ E V E LQ+ L + + E + LE+
Sbjct: 1254 KTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLES 1313
Query: 795 ERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQQVELKDAV 854
E L + +L+ ++L AE R + E ++LL+ + L QVE A
Sbjct: 1314 ELMELHETMASLQ---SRLRRAELQRMEAQGE-------RELLQAAKENLTAQVEHLQAA 1363
Query: 855 LDDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDN-----RDLTKQVTVHARTLTT 909
+ ++ A+ SA + L+++L R A KLK E ++ + L +Q +
Sbjct: 1364 VVEARAQASA----AGILEEDLRTARSAL-KLKNEEVESERERAQALQEQGELKVAQGKA 1418
Query: 910 LREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSDTKYKILEGRNESALK 969
L+E+L L + E++ L +++++ RE+ + + L+ RN+
Sbjct: 1419 LQENLALLTQTLAEREEEVETLRGQIQELEKQREM----QKAALELLSLDLKKRNQE--- 1471
Query: 970 TTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAG 1029
+ +++E+I LE L ++ Q L + E +R+ + + + +N +H
Sbjct: 1472 --VDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLL 1529
Query: 1030 KTAASHQGKEAWGPGHKEATMELLRVKDRAIELERNNAALQAEKQLLKEQLQHLETQNVT 1089
+ Q E+ ++ +L+ ++ A+ELE N+ ++ +++L+KE ETQ V
Sbjct: 1530 ELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVA 1589
Query: 1090 FSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETE 1149
+ L L+++S LQ ++ + + V L + + +Q ++ KE
Sbjct: 1590 LTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHL 1649
Query: 1150 NESLQRQQEQLTAAYEAL--LQDHEHLGT-LHERQSAEYEALIRQHSCLKTLHRNLELEH 1206
+ L+R+ ++L E + L+D T + E + + +R+ T R L E
Sbjct: 1650 TQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQER 1709
Query: 1207 KELGE-----RHGDMLKRKAELEEREKVLTTEREAL--------QQEQRTNAL--AMGEN 1251
E G+ + G + K L ++EK + ++E + Q EQ+ L +GE
Sbjct: 1710 AEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGET 1769
Query: 1252 QRLRGELDR-VNFLHHQLKGEYEELHAHTKELKTSLNNAQLELNRWQARFDELKEQHQTM 1310
L + ++ + L QL+ E+ + L++ L+ AQ L + + L+++ Q
Sbjct: 1770 SLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQA 1829
Query: 1311 DISLTKLDNHCELLSRLKGNLEEENHHLLSQIQLLSQQNQML--LEQNMENKEQYHEEQK 1368
++ E L+G LE+ + L + L + LE+ + + + + +
Sbjct: 1830 QGQEERVK---EKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALE 1886
Query: 1369 QYIDKLNALRRHKEK----LEEKIMDQYKFYDPPPKK-KNHWIGAKALVKLIKPKKEGSR 1423
+ + L A R +EK L+++ +Q + ++ + ++ W+ A+A++K +++
Sbjct: 1887 EVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLK----ERDQEL 1942
Query: 1424 ERLKSTVDSPPWQLESSDPASPAASQPL 1451
E L++ S Q E++ + A + L
Sbjct: 1943 EALRAESQSSRHQEEAARARAEALQEAL 1970
Score = 161 bits (407), Expect = 7e-39
Identities = 317/1418 (22%), Positives = 597/1418 (42%), Gaps = 194/1418 (13%)
Query: 70 DVNLRIQNLTILVRNIKTYYQEVLQQLIVMNLPNVLMIGRDPLSGKSMEEIKKVLLLVLG 129
D+ ++Q L+ +++ E QQ V+ + G+ + +++ + K+V+ +
Sbjct: 754 DLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTK----GQLEVQIQTVTQAKEVIQGEVR 809
Query: 130 CA---VQCERKEEFIER---IKQLDIETQAGIVAHIQEVTHNQENVFDLQ--WLELPDVA 181
C + ER + ER +QL Q G A Q+ +++ V L+ W +
Sbjct: 810 CLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWH 869
Query: 182 PEEL----EALSRSMVLHLRRLIDQRDECTELIVDLTQERDYLQAQHPPSPIKSSSADST 237
+EL E+L R + RL +Q+ E + +ER QA+ ++ +
Sbjct: 870 QQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERT--QAESALCQMQLETEKER 927
Query: 238 PSPTSSLSSEDKQHLAVELADTKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQKVKQE 297
S +L K ELAD +L R+RQ+++ + + +T + + E Q+ +E
Sbjct: 928 VSLLETLLQTQK-----ELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKE 982
Query: 298 NIQLAADARSARAYRDELDSLREKANRVERLELELTRCKEKLHDVDFYKARMEELREDNI 357
+AR +RD+L +L+E+++ + + +++L + E L K+++ ++D+
Sbjct: 983 ---------AARQHRDDLAALQEESSSLLQDKMDLQKQVEDL------KSQLVA-QDDSQ 1026
Query: 358 ILIETKAMLEEQLTAARARGDKVHELEKEN----LQLKSKLHDLELDRDTDKKRIEELLE 413
L+E + ++E+L + ELE+E L L K L + ++ D R +EL
Sbjct: 1027 RLVEQE--VQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELS- 1083
Query: 414 ENMVLEIAQKQSMNESAHLGWELEQLSKNADL--SDASRKSFVFELNECASSRILKLEKE 471
A +Q M E+ E ++LS +L + K F E +L +E
Sbjct: 1084 -------ALRQDMQEAQG---EQKELSAQMELLRQEVKEKEADFLAQEA------QLLEE 1127
Query: 472 NQSLQSTIQGLRDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLE--REKQSNQDLET 529
++ T Q LR ASL +E+ K +L+ ++E L + + + Q+ L +
Sbjct: 1128 LEASHITEQQLR-ASLWAQEA--KAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLAS 1184
Query: 530 LSEELIREKEQLQSDMETLKA--DKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKD 587
L L + + L D A + LE +++ + +S+EA
Sbjct: 1185 LYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASA 1244
Query: 588 VEKENKALHQT----------VTEANGKLSQLEFEKRQLHRDLE----QAKEKGERAEKL 633
+ K ++ L +T V + +L+ E EK Q+H +L+ Q + E K
Sbjct: 1245 LHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKW 1304
Query: 634 ERELQRLQEENGRLARKVTSLETATEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQLE 693
E + L+ E L + SL++ + E E+QG E L+ + + N++ Q+E
Sbjct: 1305 EGKQNSLESELMELHETMASLQSRLRRAELQRMEAQG---ERELLQAAKE---NLTAQVE 1358
Query: 694 GLERDNKQLDAENLELRRLVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKK 753
L+ + A+ L E +R T + ++ +N+++E E+E + AL ++
Sbjct: 1359 HLQAAVVEARAQASAAGILEEDLR---TARSALKLKNEEVESERERAQ-------ALQEQ 1408
Query: 754 SERLELSYQSVSAENLRL-QQSLESSSHKTQTLESELGELEAERQALRRDLEALRL---- 808
E L+++ ENL L Q+L + +TL ++ ELE +R+ + LE L L
Sbjct: 1409 GE-LKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKK 1467
Query: 809 -------ANAQLEGAEKDRKALE-----------------QEVAQLEKDKKLLEKEAKRL 844
Q++ EK R LE +++ +LEKD++ +
Sbjct: 1468 RNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQ 1527
Query: 845 WQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDNRDLTKQVTVHA 904
++E KD +++ ++ ++K+ L+ + K++ +K ++L Q
Sbjct: 1528 LLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQR 1587
Query: 905 RTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSDTKYKILEG-- 962
LT L DL + Q SS++ L E L REL QE D ++ + +E
Sbjct: 1588 VALTHLTLDLEERSQELQAQSSQIHDL--ESHSTVLAREL--QERDQEVKSQREQIEELQ 1643
Query: 963 RNESALKTTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLKKECETLRQNQGEGQHLQN 1022
R + L L ++++++L Q E L Q + ++L+++ E ++ + E
Sbjct: 1644 RQKEHLTQDLERRDQELML---QKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELT 1700
Query: 1023 SFKHPAGKTAASHQGKEAWGPGHKEATMELLRVKDRAIELERNNA-ALQAEKQLLKEQLQ 1081
+ + + A +G G E +LR K++ +E ++ + LQ K L++QLQ
Sbjct: 1701 TQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQ 1760
Query: 1082 HLETQNVTFSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQN 1141
L + V +S +L+ ++Q + + Q Q A+ Q E S QS AQ L Q
Sbjct: 1761 GLH-RKVGETSLLLSQREQEIVVLQQ----QLQEAREQGELKEQSLQSQLDEAQRALAQ- 1814
Query: 1142 HHTAKETENESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRN 1201
++ E E+LQ++Q+Q E + E+ A AL + H LK H
Sbjct: 1815 ----RDQELEALQQEQQQAQGQEERV----------KEKADALQGALEQAHMTLKERHGE 1860
Query: 1202 LELEHKELGERHGDMLK---------------RKAELEEREKVLTT-----EREALQQEQ 1241
L+ +HKE R + L +AE E+EK L +A + E
Sbjct: 1861 LQ-DHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEV 1919
Query: 1242 RTNAL------AMGENQRLRGELDRVNFLHHQLKGEYEELHAHTKELKTSLNNAQLELNR 1295
T AL A + EL+ + + + E A + L+ +L A L
Sbjct: 1920 ETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQG 1979
Query: 1296 WQARFDELKEQHQTMDISLTKLDNHCELLSRLKGNLEEENHHLLSQIQ---LLSQQNQML 1352
+ E E ++++ S L + LEE +IQ L Q++
Sbjct: 1980 KEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQ 2039
Query: 1353 LEQNMENKEQ---YHEEQKQYIDKLNALRRHKEKLEEK 1387
L+Q + +++ + +E++Q ++K A R + ++EK
Sbjct: 2040 LQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEK 2077
Score = 142 bits (358), Expect = 3e-33
Identities = 274/1302 (21%), Positives = 523/1302 (40%), Gaps = 208/1302 (15%)
Query: 270 LEDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSARAYRDELDSLREKANRVERLE 329
+E ++ L + + + QLVLE Q + + A S R ++ ++ + +A V +L+
Sbjct: 1 METRSPGLNNMKPQSLQLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQ 60
Query: 330 LELTRCKEKLHDVDF--------YKARMEELREDNIILIETKAMLEEQLTAARARGDKVH 381
++ + + +++ R E + E N L+E L +
Sbjct: 61 AKVLQYRSWCQELEKRLEATGGPIPQRWENVEEPN---------LDELLVRLEEEQQRCE 111
Query: 382 ELEKENLQLKSKLHDLELDRDTDKKRIEELLEENMVLEIAQKQSMNESAHLGWELEQ--- 438
L + N QL+ + ++ ++ +E+L + A+ + M + + W++EQ
Sbjct: 112 SLAEVNTQLRLHMEKADVVNKALREDVEKLTVD---WSRARDELMRKESQ--WQMEQEFF 166
Query: 439 ----LSKNADLSDASRKSFVF-----ELNECASSRILKLEKENQSLQSTI---------- 479
++ L R+ F E+ +++L+ E+ L ++
Sbjct: 167 KGYLKGEHGRLLSLWREVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVG 226
Query: 480 ------------QGLRDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDL 527
G A L+L + K ELEKE H+ S+++ +L++Q + EK QD
Sbjct: 227 AQSREPNGSGRMDGREPAQLLLLLA--KTQELEKEAHERSQELIQLKSQGDLEKAELQDR 284
Query: 528 ETLSEELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQ---VSSEAR 584
T L+ + ++ D E + ++ LE L SL +Q +S +
Sbjct: 285 VTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQV 344
Query: 585 MKDVEKENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEK--LERELQRLQE 642
+KD+ + + + +G + LE + + Q +K + L R Q +Q+
Sbjct: 345 IKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQD 404
Query: 643 ENGRLARKVTSLETATEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEG----LERD 698
+LA ++ ++ + E E + L+ + L DTL ++ L+G L ++
Sbjct: 405 LRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKE 464
Query: 699 NKQLDAENLELRRLVETMRFTSTKL-------------AQMERENQQLE-----REKEEL 740
+ L ELR+ +E + + +L AQ ++E QQ E RE+E L
Sbjct: 465 RELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERL 524
Query: 741 RKNVDLLKALGKKS--------ERLELSY----------QSVSAENLRLQQSLESSSHKT 782
++ + L+A +S E LE S+ V+A R +QS+ S
Sbjct: 525 QEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSE 584
Query: 783 QTLESELGELEAERQALRRDLEALRLAN------------------AQLEGAEKDRKALE 824
TL++E+ +L A L EAL L +++E AE+ R AL+
Sbjct: 585 NTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQ 644
Query: 825 QEVAQLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCR-DAA 883
++A+ EK ++ L ++ L Q++ + + A L +++E + K+L+ R
Sbjct: 645 VDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQE 704
Query: 884 GKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEK----LKSQQLSSELDKLSQELEKVG 939
+LE+ +++ +Q V AR + +E LV EK ++ Q + + L+++L+ +
Sbjct: 705 AATTQLEQLHQEAKRQEEVLARAVQE-KEALVREKAALEVRLQAVERDRQDLAEQLQGLS 763
Query: 940 LNRELLLQE--DDSGSDTKYKILEGRNESALKTTLAMK-----EEKIVLLEAQMEEKASL 992
+ELL + ++ ++ +G+ E ++T K E + + LE E +
Sbjct: 764 SAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAE 823
Query: 993 NRQLESELQMLKKECE---TLRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWG-PGHKEA 1048
+ + Q+ + E E L Q + + N + K + HQ + A +
Sbjct: 824 QERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLERE 883
Query: 1049 TMEL-LRVKDR-----AIELERNNAALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSA 1102
MEL +R+K++ AI+ +R QAE L + QL+ E + V+ +L QK+ A
Sbjct: 884 KMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLE-TEKERVSLLETLLQTQKELA 942
Query: 1103 ----------------FLQEHNTT--LQTQ------------------TAKLQVENSTLS 1126
L+E TT LQTQ A LQ E+S+L
Sbjct: 943 DASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLL 1002
Query: 1127 SQSAALTAQYTLLQNHHTAKETENESLQRQ-QEQLTAAYEALLQDHEHLGTLHERQSAEY 1185
L Q L++ A++ ++++ QE+L Q++ + ER+ A
Sbjct: 1003 QDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRET-----QEYNRIQKELEREKASL 1057
Query: 1186 E-ALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAELEEREKVLTTEREALQQE-QRT 1243
+L+ + L L + +EL DM + + E +K L+ + E L+QE +
Sbjct: 1058 TLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGE----QKELSAQMELLRQEVKEK 1113
Query: 1244 NALAMGENQRLRGELDRVNFLHHQLKGEYEELHAHTKELKTSLNNAQLELNRWQARFDEL 1303
A + + +L EL+ + QL+ A +L+ L + + +L A
Sbjct: 1114 EADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPG 1173
Query: 1304 KE-QHQTMDISL-----TKLDNHCELLSRLKG---------NLEEENHHLLSQIQLLSQQ 1348
+ Q Q SL L + CE L G LE + + S +
Sbjct: 1174 NQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLL 1233
Query: 1349 NQMLLEQNMENKEQYHEEQKQYIDKLNALRRHKEKLEEKIMD 1390
+ E + H++ + + LR +KLEE++ D
Sbjct: 1234 TALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTD 1275
Score = 137 bits (344), Expect = 1e-31
Identities = 236/1155 (20%), Positives = 462/1155 (40%), Gaps = 133/1155 (11%)
Query: 241 TSSLSSEDKQHLAVELADTKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQKVKQENIQ 300
T + + Q L L DT+A +V EL+D QL + E + + ++ E ++
Sbjct: 1258 TRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELME 1317
Query: 301 LAADARS--ARAYRDELDSLREKANRVERLELELTRCKEKL-HDVDFYKARMEELREDNI 357
L S +R R EL + + R EL L KE L V+ +A + E R
Sbjct: 1318 LHETMASLQSRLRRAELQRMEAQGER----EL-LQAAKENLTAQVEHLQAAVVEARAQ-- 1370
Query: 358 ILIETKAMLEEQLTAARA----RGDKVHELEKENLQLKSKLHDLELDRDTDKKRIEELLE 413
+LEE L AR+ + ++V E E+E Q + +L++ + + L+
Sbjct: 1371 --ASAAGILEEDLRTARSALKLKNEEV-ESERERAQALQEQGELKVAQG-------KALQ 1420
Query: 414 ENMVL---EIAQKQSMNESAHLGWELEQLSKNADLSDASRKSFVFELN------ECASSR 464
EN+ L +A+++ E+ L ++++L K ++ A+ + +L + +
Sbjct: 1421 ENLALLTQTLAEREEEVET--LRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQ 1478
Query: 465 ILKLEKENQSLQSTIQGLRDASLVLEESGLKCGELEKE--------NHQLSKKIEKLQTQ 516
I +LEK L+ +++ L + ELEK+ HQL ++EK
Sbjct: 1479 IQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQL-LELEKKDQM 1537
Query: 517 LEREKQSNQDLE---TLSEELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSL 573
+E ++ QDL+ E L E E+ ME + + IK+LE +++ A+ L
Sbjct: 1538 IESQRGQVQDLKKQLVTLECLALELEENHHKMEC----QQKLIKELEGQRETQRVALTHL 1593
Query: 574 RERSQVSSEARMKDVEKENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKL 633
+ E R ++++ ++ +H + + +L+ +++ EQ +E + E L
Sbjct: 1594 ----TLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHL 1649
Query: 634 ERELQRLQEENGRLARKVTSLE-TATEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQL 692
++L+R +E ++ LE T + + LE + + ++L R + L T + L
Sbjct: 1650 TQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQR--QLMQ 1707
Query: 693 EGLERDNKQLDAENLELRRLVETMRFTSTKLAQMERENQQLEREKEELRKNVD-LLKALG 751
E E A+ L + +R ++ + +L+ K++L + + L + +G
Sbjct: 1708 ERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVG 1767
Query: 752 KKSERLELSYQSVSAENLRLQQSLESSSHKTQTLESELGELEAERQALRRDLEALRLANA 811
+ S L Q + +LQ++ E K Q+L+S+L EA+R +RD E
Sbjct: 1768 ETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLD--EAQRALAQRDQEL------ 1819
Query: 812 QLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRA 871
+AL+QE Q + ++ ++++A L +E L + +L ++++R
Sbjct: 1820 ---------EALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARR 1870
Query: 872 LDKELA----RCRDAAGKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQ----Q 923
L++ELA R + L +L ++R+ K + + ++ +E Q Q
Sbjct: 1871 LEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQ 1930
Query: 924 LSSELDKLSQELEKVGLNRELLLQEDDSGSDTKYKILEGRNESALKTTLAMKEEKIVLLE 983
+ L + QELE L+ + S + + R E AL+ L + E
Sbjct: 1931 AQAVLKERDQELE--------ALRAESQSSRHQEEAARARAE-ALQEALGKAHAALQGKE 1981
Query: 984 AQMEEKASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGP 1043
+ E+A L+R LE+ L+ + Q + L+ + + G+ Q ++
Sbjct: 1982 QHLLEQAELSRSLEASTATLQASLDAC---QAHSRQLEEALRIQEGEI----QDQDLRYQ 2034
Query: 1044 GHKEATMELLRVKDRAIELERNNAALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAF 1103
+ + L +D + + Q +QLL++ L +N+ Q L +++
Sbjct: 2035 EDVQQLQQALAQRDEELRHQ------QEREQLLEKSLAQRVQENMIQEKQNLGQEREEEE 2088
Query: 1104 LQE-HNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETENESLQ------RQ 1156
++ H + + Q Q E L + L + H E +SL+ R
Sbjct: 2089 IRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRL 2148
Query: 1157 QEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGERHGDM 1216
Q +L AL Q E+ +L + + + +L + ER +
Sbjct: 2149 QRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQ 2208
Query: 1217 LKRKAELEEREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQLKGEYEELH 1276
+ + ELE + L E+E L T+ +G +GE
Sbjct: 2209 QRLQDELELTRRAL--EKERLHSPGATSTAELGS------------------RGEQGVQL 2248
Query: 1277 AHTKELKTSLNNAQLELNRWQARFDELKEQHQTMDISLTKLDNHCELLSRLKGNLEEENH 1336
++ + +E W+ R + L++ ++I ++L H L +E E
Sbjct: 2249 GEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERR 2308
Query: 1337 HLLSQIQLLSQQNQM 1351
L + +Q +
Sbjct: 2309 KLKREAMRAAQAGSL 2323
Score = 121 bits (304), Expect = 6e-27
Identities = 238/1075 (22%), Positives = 429/1075 (39%), Gaps = 194/1075 (18%)
Query: 114 GKSMEEIKKVLLLVLGCAVQCERKEEFIERIKQLDIETQAGIVAHIQEVTHNQENVFDLQ 173
GK+++E +L L ER+EE +ET G + +++ Q+ +L
Sbjct: 1416 GKALQENLALLTQTLA-----EREEE---------VETLRGQIQELEKQREMQKAALELL 1461
Query: 174 WLELP------DVAPEELEALS--RSMVLHL--------RRLIDQRDECTELIVDLTQER 217
L+L D+ E+++ L RS++ HL ++L QR++ EL D +R
Sbjct: 1462 SLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQR 1521
Query: 218 DYLQAQHPPSPIKSSSADSTPSPTSSLSSE--DKQHLAVELADTKARLRRVRQELEDKTE 275
+ L+ Q K +S L + + LA+EL + ++ ++ +++
Sbjct: 1522 NVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEG 1581
Query: 276 QLVDTRHEVDQLVLELQKVKQENIQLAADARSARAYRDELDSLREKANRVERLELELTRC 335
Q R + L L+L++ QE ++ ++ L RE R + ++ + +
Sbjct: 1582 QRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVL--ARELQERDQEVKSQREQI 1639
Query: 336 KEKLHDVDFYKARMEELREDNIILIETKAMLEEQLTAARARGDKVHELEKENLQLKSKLH 395
+E + +E ++ ++ E +LE+Q R R K+ LE++ Q+K L
Sbjct: 1640 EELQRQKEHLTQDLERRDQELMLQKERIQVLEDQ----RTRQTKI--LEEDLEQIKLSLR 1693
Query: 396 DLELDRDTDKKRIEELLEENMVLEIAQKQSMNESAHLGWELEQLSKNADLSDASRKSFVF 455
+ + T ++ ++E EE AQ+ S+ H+ L K
Sbjct: 1694 ERGRELTTQRQLMQERAEEGKGPSKAQRGSLE---HMKLILRDKEKEV------------ 1738
Query: 456 ELNECASSRILKLEKENQSLQSTIQGLR----DASLVL----EESGLKCGELEKENHQLS 507
EC I +L++ L+ +QGL + SL+L +E + +L++ Q
Sbjct: 1739 ---ECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGE 1795
Query: 508 KKIEKLQTQLEREK----QSNQDLETLS---------EELIREK-EQLQSDME----TLK 549
K + LQ+QL+ + Q +Q+LE L EE ++EK + LQ +E TLK
Sbjct: 1796 LKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLK 1855
Query: 550 A------DKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEAN 603
D Q + LE+E R + +L E V + R + E+E KAL +
Sbjct: 1856 ERHGELQDHKEQARRLEEELAVEGRRVQALEE---VLGDLRAESREQE-KALLALQQQCA 1911
Query: 604 GKLSQLEFEKRQLHRDLEQA----KEKGERAEKLERELQRLQEENGRLARKVTSLETATE 659
+ + E E R L QA KE+ + E L E Q + + + +L+ A
Sbjct: 1912 EQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALG 1971
Query: 660 KVEA---------LEHE--SQGLQLENRTLRKSLDTLQNVSLQLEGLERDNK-------- 700
K A LE S+ L+ TL+ SLD Q S QLE R +
Sbjct: 1972 KAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDL 2031
Query: 701 --QLDAENL---------ELRRLVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKA 749
Q D + L ELR E + LAQ +EN E++ + + ++
Sbjct: 2032 RYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRG 2091
Query: 750 LGKKSERLELSYQSVSAENLRLQQSLESS-------SHKTQTLESELGELEAERQALRRD 802
L + L+L+ E L L+++ + + SHKT +E + +L++ L+R+
Sbjct: 2092 LHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRE 2151
Query: 803 LEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKL 862
LE L+ A Q E E + + Q++A L + A +
Sbjct: 2152 LERLQAALRQTEAREIEWREKAQDLA------------------------LSLAQTKASV 2187
Query: 863 SAVEKESRALDKELARCRDAAGKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQ 922
S++++ + L + LE+D+ Q L R L E+L S
Sbjct: 2188 SSLQEVAMFLQASV------------LERDSEQQRLQ-----DELELTRRALEKERLHSP 2230
Query: 923 QLSSELDKLSQELEKVGLNRELLLQEDDSGSDTKYKILEGRNESALKTTLAMKEEKIVLL 982
+S + S+ + V L ++ + S +G + + + L ++ + L
Sbjct: 2231 GATSTAELGSRGEQGVQLGEVSGVEAEPSP--------DGMEKQSWRQRLEHLQQAVARL 2282
Query: 983 EAQMEEKASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWG 1042
E N QL S L+ +++E L++ E + K AS ++ G
Sbjct: 2283 EIDRSRLQRHNVQLRSTLEQVERERRKLKR---EAMRAAQAGSLEISKATASSPTQQD-G 2338
Query: 1043 PGHKEATMELLRVKDRAIELERNNAALQAEKQLLKEQLQHLETQNVTFSSQILTL 1097
G K + + + EL++ LQA+ L ++Q Q T++ S ++ L
Sbjct: 2339 RGQKNSDAKCV------AELQKEVVLLQAQLTLERKQKQDYITRSAQTSRELAGL 2387
Score = 48.9 bits (115), Expect = 5e-05
Identities = 114/553 (20%), Positives = 212/553 (38%), Gaps = 64/553 (11%)
Query: 112 LSGKSMEEIKKVLLLVLGCAVQCERKEEFIERIKQLDIETQAGIVAHIQEVTHNQENVFD 171
L +S E+ K +L L CA Q + E +ET+A + +Q +E +
Sbjct: 1892 LRAESREQEKALLALQQQCAEQAQEHE----------VETRALQDSWLQAQAVLKERDQE 1941
Query: 172 LQWLELPDVAPEELEALSRSMVLHLRRLIDQRDECTELIVDLTQERDYLQAQHPPSPIKS 231
L+ L + E +R+ L+ + + + +E+ L+ +++
Sbjct: 1942 LEALRAESQSSRHQEEAARARAEALQEALGKAHAALQ-----GKEQHLLEQAELSRSLEA 1996
Query: 232 SSADSTPSPTSSLSSEDKQHLAV-----ELADTKAR----LRRVRQELEDKTEQLVDTRH 282
S+A S + + + A+ E+ D R +++++Q L + E+L +
Sbjct: 1997 STATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQE 2056
Query: 283 EVDQLVLELQKVKQENI----QLAADARSARAYRDELDSLRE-----KANRVERLELELT 333
L L + QEN+ Q R R S+RE E LEL T
Sbjct: 2057 REQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRET 2116
Query: 334 RCKEKLHDVDFYKARMEELREDNIILIETKAMLEEQLTAARARGDKVHELEKENLQLKSK 393
+ + L + + + + E ++ L + L+ +L +A + + E ++ + K
Sbjct: 2117 QQRNNLEALP-HSHKTSPMEEQSLKLDSLEPRLQRELERLQA---ALRQTEAREIEWREK 2172
Query: 394 LHDLELDRDTDKKRIEELLEENMVLEIAQKQSMNESAHLGWEL---------EQLSKNAD 444
DL L K + L E M L+ + + +E L EL E+L
Sbjct: 2173 AQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGA 2232
Query: 445 LSDA---SRKSFVFELNECASSRILKLE--KENQSLQSTIQGLRDASLVLEESGLKCGEL 499
S A SR +L E + E QS + ++ L+ A LE + L
Sbjct: 2233 TSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLE---IDRSRL 2289
Query: 500 EKENHQLSKKIEKLQTQ---LEREKQSNQDLETLSEELIREKEQLQSDMETLKADKARQI 556
++ N QL +E+++ + L+RE +L Q D K A+ +
Sbjct: 2290 QRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCV 2349
Query: 557 KDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEANGKLSQ------LE 610
+L++E L +A +L + + R +E LH +++ + ++Q LE
Sbjct: 2350 AELQKEV-VLLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQAPEATVLE 2408
Query: 611 FEKRQLHRDLEQA 623
E R+L L Q+
Sbjct: 2409 AETRRLDESLTQS 2421
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 170 bits (431), Expect = 1e-41
Identities = 253/1101 (22%), Positives = 464/1101 (42%), Gaps = 105/1101 (9%)
Query: 290 ELQKVKQENIQLAADARSARAYRDELDSLREKANRVERLELELTRCKEKLHDVDFYKARM 349
ELQKV++ Q A + + +L+ E+A E+L E C E AR
Sbjct: 885 ELQKVQELQQQSAREVGELQGRVAQLEE--ERARLAEQLRAEAELCAEAEETRGRLAARK 942
Query: 350 EELREDNIILIETKAMLEEQLTAARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIE 409
+EL +++ E +A + E+ +R +++ E +L+ + +LE + ++ +
Sbjct: 943 QELE---LVVSELEARVGEEEECSR-------QMQTEKKRLQQHIQELEAHLEAEEGARQ 992
Query: 410 ELLEENMVLEIAQKQSMNESAHLGWELEQLSKNADLSDASRKSFVFELNECASSRILKLE 469
+L E + E K+ + L + +LSK L + F + E ++ L
Sbjct: 993 KLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAE-EEEKVKSLN 1051
Query: 470 KENQSLQSTIQGLRDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLET 529
K ++TI + D L EE G + ELEK +L + +LQ Q+ ++Q ++L
Sbjct: 1052 KLRLKYEATIADMEDR-LRKEEKGRQ--ELEKLKRRLDGESSELQEQMVEQQQRAEELRA 1108
Query: 530 LSEELIREKEQLQSDMETLKAD---KARQIKDLEQEKDHLNRAMWSLRER--SQVSSEAR 584
+L R++E+LQ+ + + + +A+ +K L + + L A L ++ +E +
Sbjct: 1109 ---QLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQ 1165
Query: 585 MKDVEKENKALH---QTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQ 641
+D+ +E +AL + ++ +L ++ Q +L++ E+ R E +Q L+
Sbjct: 1166 RRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIH--EAAVQELR 1223
Query: 642 EENGR-LARKVTSLETATEKVEALEHESQGLQLENRTLRKSLDTLQN-----------VS 689
+ +G+ L LE A A E L+ E LR L +LQ +
Sbjct: 1224 QRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLE 1283
Query: 690 LQLE---GLERDNKQLDAENLE-LRRLVETMRFTSTKLAQMERENQQLEREKEELRKNVD 745
LQL+ G D ++ AE E L+R + S L + E + +L +E +
Sbjct: 1284 LQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLH 1343
Query: 746 LLKALGKKSERLELSYQS----VSAENLRLQQSLESSSHKTQTLESELGELEAERQALRR 801
+ L ++ R +L+ S + AE L++ LE + + EL +A+ RR
Sbjct: 1344 DAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRR 1403
Query: 802 DLE----ALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQQVELKDAVLDD 857
E AL A ++ +AL Q +A+ + LE+ +RL Q+++ L+
Sbjct: 1404 RQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQ 1463
Query: 858 STAKLSAVEKESRALDKELARCRDAAGKLKELEKDNRDLTKQVTVHARTLTTLR----ED 913
+S +EK+ R D+ LA + A L+ +E+ R + AR L+ R E
Sbjct: 1464 QRQLVSTLEKKQRKFDQLLA--EEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQ 1521
Query: 914 LVLEKLKSQQ--LSSELDKLSQELEKVG-----LNRELLLQEDDSGSDTKYKILEGRNES 966
E+L+ Q L +EL+ L + VG L R + E + +D + ++ E +E
Sbjct: 1522 EAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAE-QAANDLRAQVTELEDEL 1580
Query: 967 ALK---------TTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLKKECETLRQNQ--- 1014
T A+K + L+ + E RQL +L+ + E + R+ +
Sbjct: 1581 TAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLA 1640
Query: 1015 -GEGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEATMELLRVKDRAIELERNNAALQAEK 1073
+ L+ + + A++ QGKE EA +L +++ + EL R + +
Sbjct: 1641 VAARKKLEGELEELKAQMASAGQGKE-------EAVKQLRKMQAQMKELWREVEETRTSR 1693
Query: 1074 QLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQSAALT 1133
+ + Q + E + +++L LQ++ A Q ++ E + + AA+
Sbjct: 1694 EEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAIL 1753
Query: 1134 AQYTLLQNHHTAKETENESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHS 1193
+ L+ E E E Q E L Y LL E L T SAE + S
Sbjct: 1754 EEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTT---ELSAERSFSAKAES 1810
Query: 1194 CLKTLHRNLELEHKELGERH-GDMLKRKAELEEREKVLTTEREALQQEQR----TNALAM 1248
+ L R ++ LGE G + K + E L E L+QE R + L
Sbjct: 1811 GRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVR 1870
Query: 1249 GENQRLRG---ELDRVNFLHHQLKGEYEELHAHTKELKTSLNNAQLELNRWQA------- 1298
+RL+ +++ + QL+ + E+ + K+LK L A+ E +R QA
Sbjct: 1871 RAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQR 1930
Query: 1299 RFDELKEQHQTMDISLTKLDN 1319
+++ E ++M+ +T L N
Sbjct: 1931 ELEDVTESAESMNREVTTLRN 1951
Score = 148 bits (374), Expect = 5e-35
Identities = 244/1048 (23%), Positives = 439/1048 (41%), Gaps = 136/1048 (12%)
Query: 158 HIQEV-THNQENVFDLQWLELPDVAPEELEALSRSMVLHLRRLIDQRDECTELIVDLTQE 216
HIQE+ H + Q L+L V E A + L L DQ + L++E
Sbjct: 976 HIQELEAHLEAEEGARQKLQLEKVTTE---AKMKKFEEDLLLLEDQNSK-------LSKE 1025
Query: 217 RDYLQAQHPPSPIKSSSADSTPSPTSSLSSEDKQHLAVELADTKARLRRV---RQELE-- 271
R L+ + SS A SL+ ++ A +AD + RLR+ RQELE
Sbjct: 1026 RKLLEDRLAEF---SSQAAEEEEKVKSLNKLRLKYEAT-IADMEDRLRKEEKGRQELEKL 1081
Query: 272 ---------DKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSARAYRDELDSLREKA 322
+ EQ+V+ + ++L +L + K+E +Q A ARA DE + +
Sbjct: 1082 KRRLDGESSELQEQMVEQQQRAEELRAQLGR-KEEELQAAL----ARA-EDEGGARAQLL 1135
Query: 323 NRVERLELELTRCKEKLHDVDFYKARMEELREDNIILIET-KAMLEEQLTAARARGDKVH 381
+ + L +E L + + E+ R D +E + LE+ L + A+ +
Sbjct: 1136 KSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRS 1195
Query: 382 ELEKENLQLKSKLHDLELDRDTDKKRIEELLEEN--MVLEIAQKQSMNESAHLGWELEQL 439
+ E+E +LK LE + + ++EL + + + E+A++ WE +L
Sbjct: 1196 KREQEVTELKK---TLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRL 1252
Query: 440 SKNADLSD-ASRKSFVFELNECASSRILKLEKENQSLQ-----------STIQGLRDASL 487
+ A++S+ + S + + R +LE + Q +Q + L+ A
Sbjct: 1253 ALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQA 1312
Query: 488 VLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSDMET 547
LE E E + +LSK++ + QL D + L +E R K L S +
Sbjct: 1313 ELENVSGALNEAESKTIRLSKELSSTEAQL-------HDAQELLQEETRAKLALGSRVRA 1365
Query: 548 LKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVE----------------KE 591
++A+ A + LE+E RA L+ SE R + E +E
Sbjct: 1366 MEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAARE 1425
Query: 592 NKALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEE-NGRLARK 650
+AL Q + E + +LE +R+L ++L+ A E+ +L L++ Q + + LA +
Sbjct: 1426 AEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEE 1485
Query: 651 VTSLETATEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELR 710
++ A E+ E E E + + +L ++L+ Q E LER N+ L A EL
Sbjct: 1486 KAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAR---EELERQNRALRA---ELE 1539
Query: 711 RLVETMRFTSTKLAQMERENQQLEREKEELRKNV----DLLKALGKKSERLELSYQSVSA 766
L+ + + ++ER + E+ +LR V D L A RLE++ Q++
Sbjct: 1540 ALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKT 1599
Query: 767 ENLR-LQQSLESSSHKTQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKA--- 822
++ R LQ E+ + + L +L + E ER R+ A +LEG ++ KA
Sbjct: 1600 QHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMA 1659
Query: 823 -----LEQEVAQLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELA 877
E+ V QL K ++ + K LW++VE ++ ++ EK + L+ E+
Sbjct: 1660 SAGQGKEEAVKQLRK----MQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVL 1715
Query: 878 RCRD---AAGKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQE 934
R ++ A+ + + + +RD + L + +LE + +QL L +L +E
Sbjct: 1716 RLQEELAASDRARRQAQQDRDEMADEVANG----NLSKAAILE--EKRQLEGRLGQLEEE 1769
Query: 935 LEKVGLNRELLLQEDDSGSDTKYKILEGRNESALKTTLAMKEEKIVLLEAQMEEKASLNR 994
LE+ N ELL + +Y+ L + ES L ++ + S +
Sbjct: 1770 LEEEQSNSELL--------NDRYRKLLLQVES---------------LTTELSAERSFSA 1806
Query: 995 QLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEATMELLR 1054
+ ES Q L+++ + LR GE + +H A + +A +E +L
Sbjct: 1807 KAESGRQQLERQIQELRGRLGE-EDAGARARHKMTIAALESKLAQAEEQLEQETRERILS 1865
Query: 1055 VK-DRAIELERNNAALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEHNTTLQT 1113
K R E LQ E++ + L Q + ++ L++Q +E + Q
Sbjct: 1866 GKLVRRAEKRLKEVVLQVEEE--RRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQA 1923
Query: 1114 QTAKLQVENSTLSSQSAALTAQYTLLQN 1141
+LQ E ++ + ++ + T L+N
Sbjct: 1924 GRRRLQRELEDVTESAESMNREVTTLRN 1951
Score = 133 bits (335), Expect = 2e-30
Identities = 219/1034 (21%), Positives = 414/1034 (40%), Gaps = 130/1034 (12%)
Query: 465 ILKLEKENQSLQSTIQGLRDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQ-- 522
+L++ ++++ LQ+ Q L+ + ++S + GEL+ QL ++ +L QL E +
Sbjct: 869 LLQVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELC 928
Query: 523 ------------SNQDLETLSEEL---IREKEQLQSDMETLKADKARQIKDLEQEKDHLN 567
Q+LE + EL + E+E+ M+T K + I++LE +
Sbjct: 929 AEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEE 988
Query: 568 RAMWSLRERSQVSSEARMKDVE--------------KENKALHQTVTEANGKLSQLEFEK 613
A L + +V++EA+MK E KE K L + E + + ++ E +
Sbjct: 989 GARQKL-QLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKV 1047
Query: 614 RQLHR----------DLE---QAKEKG-ERAEKLEREL---------------QRLQEEN 644
+ L++ D+E + +EKG + EKL+R L QR +E
Sbjct: 1048 KSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELR 1107
Query: 645 GRLARKVTSLETATEKVE----ALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNK 700
+L RK L+ A + E A + L+ L ++ + L++ + E+ +
Sbjct: 1108 AQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRR 1167
Query: 701 QLDAENLELR-RLVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLEL 759
L E LR L +T+ T+ + + Q++ K+ L + + +A ++ +
Sbjct: 1168 DLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHG 1227
Query: 760 SYQSVSAENLRLQQSLESSSHKTQ-TLESELGELEAERQALRRDLEALRLANAQLEGAEK 818
AE L + + + KT+ LE+E+ EL AE +L+ A+ EG E+
Sbjct: 1228 QALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQ---------TARQEG-EQ 1277
Query: 819 DRKALEQEVAQLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKEL-- 876
R+ LE ++ +++ E+ ++++ A L++ + L+ E ++ L KEL
Sbjct: 1278 RRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSS 1337
Query: 877 --ARCRDAAGKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQE 934
A+ DA L+E + L +V LRE L E ++ EL +
Sbjct: 1338 TEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQ 1397
Query: 935 LEKVGLNRELLLQEDDSGSDTKYKILEGRNESALKTTLAMKEEKIVLLEAQMEEKASLNR 994
L + +E ++G + + + R AL LA K E + LE + L +
Sbjct: 1398 LSEWRRRQEEEAGALEAGEEARRR--AAREAEALTQRLAEKTETVDRLE---RGRRRLQQ 1452
Query: 995 QLES---ELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEATME 1051
+L+ +L+ ++ TL + Q + L K + + EA G + +
Sbjct: 1453 ELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALS 1512
Query: 1052 LLRV----KDRAIELERNNAALQAEKQLL-------KEQLQHLETQNVTFSSQILTLQKQ 1100
L R ++ ELER N AL+AE + L + + LE L+ Q
Sbjct: 1513 LTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQ 1572
Query: 1101 SAFLQEHNTTLQTQTAKLQVENSTLSSQ--------SAALTAQYTLLQNHHTAKETENES 1152
L++ T + +L+V L +Q A + L E E +
Sbjct: 1573 VTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDE 1632
Query: 1153 LQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGER 1212
++Q+ AA + L + E L E ++Q ++ + L E +E
Sbjct: 1633 ERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTS 1692
Query: 1213 HGDMLKRKAELEEREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQLKGEY 1272
++ + E E+R K L E LQ+E LA + R + + DR G
Sbjct: 1693 REEIFSQNRESEKRLKGLEAEVLRLQEE-----LAASDRARRQAQQDRDEMADEVANGNL 1747
Query: 1273 EE--LHAHTKELKTSLNNAQLELNRWQARFDELKEQHQTMDISLTKLDNHCELLSRLKGN 1330
+ + ++L+ L + EL Q+ + L ++++ + + + L
Sbjct: 1748 SKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAK 1807
Query: 1331 LEEENHHLLSQIQLL----------SQQNQMLLEQNMENK-----EQYHEEQKQYIDKLN 1375
E L QIQ L ++ + +E+K EQ +E ++ I
Sbjct: 1808 AESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGK 1867
Query: 1376 ALRRHKEKLEEKIM 1389
+RR +++L+E ++
Sbjct: 1868 LVRRAEKRLKEVVL 1881
Score = 113 bits (282), Expect = 2e-24
Identities = 197/890 (22%), Positives = 346/890 (38%), Gaps = 143/890 (16%)
Query: 133 QCERKEEFIERIKQLDIETQAGIVAHIQEVTHNQENVFDLQWLELPDVAPEELEALSRSM 192
Q +R EE ++ + + E QA + E + + L+ E E E L
Sbjct: 1099 QQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLR--EAQAALAEAQEDLESER 1156
Query: 193 VLHLRRLIDQRDECTELIVDLTQERDYLQAQHPPSPIKSSSADSTPSPTSSLSSEDKQHL 252
V + +RD EL + D L + + ++S +L E + H
Sbjct: 1157 VARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHE 1216
Query: 253 AV-------------ELADTKARLRRVR--------------QELEDKTEQLVDTRHEVD 285
A ELA+ + RR + EL + L R E +
Sbjct: 1217 AAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGE 1276
Query: 286 QLVLELQKVKQENIQLAADARSARAYRDELDSLREKANRVERLELELTRCKEKLHDVDFY 345
Q L+ QE A D ARA E A +++R + EL L++ +
Sbjct: 1277 QRRRRLELQLQEVQGRAGDGERARA---------EAAEKLQRAQAELENVSGALNEAESK 1327
Query: 346 KARM-EELREDNIILIETKAMLEEQLTAARARGDKVHELEKENLQLKSKLHDLELDRDTD 404
R+ +EL L + + +L+E+ A A G +V +E E L+ +L + R+
Sbjct: 1328 TIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERA 1387
Query: 405 KKRIEELL-----------EENMVLEI---AQKQSMNESAHLGWELEQLSKNADLSDASR 450
+ ++ EE LE A++++ E+ L L + ++ D + R
Sbjct: 1388 GRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGR 1447
Query: 451 KSFVFELNECASSR------ILKLEKENQSLQSTIQGLRDASL----------------- 487
+ EL++ + LEK+ + + + A L
Sbjct: 1448 RRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGRERE 1507
Query: 488 --------VLEESGLKCGELEKENHQLSKKIEKLQT----------QLERE----KQSNQ 525
LEE ELE++N L ++E L + +LER +Q+
Sbjct: 1508 ARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAAN 1567
Query: 526 DLETLSEELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARM 585
DL EL E E ++ L+ + Q + E+D R R Q++ + R
Sbjct: 1568 DLRAQVTEL--EDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRD 1625
Query: 586 KDVEKENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENG 645
+VE++ + +T+ A K +LE E +L + A G+ E+ ++L+++Q +
Sbjct: 1626 AEVERDEERKQRTLAVAARK--KLEGELEELKAQMASA---GQGKEEAVKQLRKMQAQMK 1680
Query: 646 RLARKVTSLETATEKVEALEHESQ----GLQLENRTLRKSLDTLQNVSLQLEGLERDNKQ 701
L R+V T+ E++ + ES+ GL+ E L++ L Q + +RD
Sbjct: 1681 ELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQ-DRDEMA 1739
Query: 702 LDAENLELRR--LVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLEL 759
+ N L + ++E R Q+E QLE E EE + N +LL + +L L
Sbjct: 1740 DEVANGNLSKAAILEEKR-------QLEGRLGQLEEELEEEQSNSELLN---DRYRKLLL 1789
Query: 760 SYQSVSAE-------NLRLQQSLESSSHKTQTLESELGELEAERQALRR-DLEALRLANA 811
+S++ E + + + + + Q L LGE +A +A + + AL A
Sbjct: 1790 QVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLA 1849
Query: 812 QLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQ---QVELKDAVLDDSTAKLSAVEKE 868
Q E + LEQE + KL+ + KRL + QVE + V D +L
Sbjct: 1850 QAE------EQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLR 1903
Query: 869 SRALDKELARCRDAAGKL----KELEKDNRDLTKQVTVHARTLTTLREDL 914
+ L ++L + A + + L+++ D+T+ R +TTLR L
Sbjct: 1904 VKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRL 1953
Score = 108 bits (270), Expect = 5e-23
Identities = 181/821 (22%), Positives = 338/821 (41%), Gaps = 86/821 (10%)
Query: 618 RDLEQAKEKGERAEKLERELQRLQEENGRLARKVTSLETATEKVEALEHESQGLQLENRT 677
+ L Q + E + +ELQ++QE + AR+V L + + QLE
Sbjct: 867 KPLLQVTRQDEVLQARAQELQKVQELQQQSAREVGEL------------QGRVAQLEEER 914
Query: 678 LRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVETMRFTSTKLAQMERENQQLEREK 737
R + L E E +L A EL +V + ++ + E ++Q++ EK
Sbjct: 915 ARLAEQLRAEAELCAEA-EETRGRLAARKQELELVVSEL---EARVGEEEECSRQMQTEK 970
Query: 738 EELRKNVDLLKA--LGKKSERLELSYQSVSAEN---------LRLQQSLESSSHKTQTLE 786
+ L++++ L+A ++ R +L + V+ E L L+ S + + LE
Sbjct: 971 KRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLE 1030
Query: 787 SELGELE---AERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQ-LEKDKKLLEKEAK 842
L E AE + + L LRL +DR E++ Q LEK K+ L+ E+
Sbjct: 1031 DRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESS 1090
Query: 843 RLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDNRDLTKQVTV 902
L +Q+ + ++ A+L E+E L LAR D G +L K R+ +
Sbjct: 1091 ELQEQMVEQQQRAEELRAQLGRKEEE---LQAALARAEDEGGARAQLLKSLREAQAALAE 1147
Query: 903 HARTLTTLREDLVLEKLKSQQLSSELDKLSQELE----KVGLNRELLLQEDDSGSDTKYK 958
L + R + + + L EL+ L ELE +EL + + ++ K K
Sbjct: 1148 AQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELK-K 1206
Query: 959 ILEGR---NESALKTTLAMKEEKIVLLEAQME---------EKASLNRQLESELQMLKKE 1006
LE +E+A++ + + L Q+E EK L LE+E+ L+ E
Sbjct: 1207 TLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRL--ALEAEVSELRAE 1264
Query: 1007 CETLRQNQGEGQ----HLQNSFKHPAGKTAASHQGKEAWGPGHKEATMELLRV------- 1055
+L+ + EG+ L+ + G+ + + + A EL V
Sbjct: 1265 LSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEA 1324
Query: 1056 KDRAIELERNNAALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEHNTTLQTQT 1115
+ + I L + ++ +A+ +E LQ + S++ ++ ++A L+E L+ +
Sbjct: 1325 ESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQ---LEEEA 1381
Query: 1116 AKLQVENSTLSSQSAALTAQYTLLQNHHTAKETENESLQRQQEQLTAAYEALLQDHEHLG 1175
A + L + A L+ + A E E+ +R + A + L + E +
Sbjct: 1382 AARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVD 1441
Query: 1176 TLHE-RQSAEYEA------LIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAELEEREK 1228
L R+ + E L +Q + TL + + L E +L+ +EERE+
Sbjct: 1442 RLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLR---AVEERER 1498
Query: 1229 VLTTEREALQQEQRTNAL--AMGENQRLRGELDRVNFLHHQLKGEYEELHAHTKELKTSL 1286
E E ++E R +L A+ E Q R EL+R N L+ E E L + ++ S+
Sbjct: 1499 ---AEAEGREREARALSLTRALEEEQEAREELERQN---RALRAELEALLSSKDDVGKSV 1552
Query: 1287 NNAQLELNRWQARFDELKEQHQTMDISLTKL-DNHCELLSRLKGNLEEENHHLLSQIQLL 1345
+ + + ++L+ Q ++ LT D L ++ + L + +
Sbjct: 1553 HELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAG 1612
Query: 1346 SQQNQMLLEQNMENKEQYHEEQKQYIDKLNALRRHKEKLEE 1386
++ + L +Q + + + EE+KQ + A ++ + +LEE
Sbjct: 1613 EERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEE 1653
Score = 92.0 bits (227), Expect = 5e-18
Identities = 142/621 (22%), Positives = 261/621 (42%), Gaps = 81/621 (13%)
Query: 264 RRVRQELEDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSARAYRDELDSLREKAN 323
RR +E E T++L + VD+L ++++QE D R L+ + K +
Sbjct: 1420 RRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFD 1479
Query: 324 RV--ERLELELTRCKEKLHDVDFYKARMEELREDNIILIETKAMLEEQLTAARARGDKVH 381
++ E L +E+ +A E + L T+A+ EEQ +
Sbjct: 1480 QLLAEEKAAVLRAVEER------ERAEAEGREREARALSLTRALEEEQ--------EARE 1525
Query: 382 ELEKENLQLKSKLHDLELDRDTDKKRIEELLEENMVLEIAQKQSMNESAHLGWELEQLSK 441
ELE++N L+++L L ++ K + +S H ELE+ +
Sbjct: 1526 ELERQNRALRAELEAL----------------------LSSKDDVGKSVH---ELERACR 1560
Query: 442 NADLSDASRKSFVFELNE---CASSRILKLEKENQSLQSTIQGLRDASLVLEESGLKCGE 498
A+ + ++ V EL + A L+LE Q+L++ Q RD +E+G
Sbjct: 1561 VAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKT--QHERDLQ-GRDEAG----- 1612
Query: 499 LEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSDMETLKADKARQIKD 558
E+ QL+K++ + + + E++ ++L E E+L++ M + K +K
Sbjct: 1613 -EERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQ 1671
Query: 559 LEQEKDHLNRAMWSLRERSQVSSE---ARMKDVEKENKALHQTVTEANGKLSQLEFEKRQ 615
L + + + + +W E ++ S E ++ ++ EK K L V +L+ + +RQ
Sbjct: 1672 LRKMQAQM-KELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQ 1730
Query: 616 LHRDL-EQAKEKGERAEKLERELQRLQEENGRLARKVTSLETATEKVEALEHESQGLQLE 674
+D E A E L+ ++ GRL + LE E L + L L+
Sbjct: 1731 AQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQ 1790
Query: 675 NRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELR-RLVE-----------TMRFTSTK 722
+L L ++ S + E +QL+ + ELR RL E T+ +K
Sbjct: 1791 VESLTTELSAERSFSAKAES---GRQQLERQIQELRGRLGEEDAGARARHKMTIAALESK 1847
Query: 723 LAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSSHKT 782
LAQ E +QLE+E E + L++ K+ + + L + +L+ LE + +
Sbjct: 1848 LAQAE---EQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRV 1904
Query: 783 QTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKL--LEKE 840
+ L+ +L EAE +A R RL +LE + +++ +EV L + L
Sbjct: 1905 KQLKRQLE--EAEEEASRAQAGRRRL-QRELEDVTESAESMNREVTTLRNRLRRGPLTFT 1961
Query: 841 AKRLWQQVELKDAVLDDSTAK 861
+ + Q L++ V D A+
Sbjct: 1962 TRTVRQVFRLEEGVASDEEAE 1982
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 170 bits (431), Expect = 1e-41
Identities = 253/1101 (22%), Positives = 464/1101 (42%), Gaps = 105/1101 (9%)
Query: 290 ELQKVKQENIQLAADARSARAYRDELDSLREKANRVERLELELTRCKEKLHDVDFYKARM 349
ELQKV++ Q A + + +L+ E+A E+L E C E AR
Sbjct: 877 ELQKVQELQQQSAREVGELQGRVAQLEE--ERARLAEQLRAEAELCAEAEETRGRLAARK 934
Query: 350 EELREDNIILIETKAMLEEQLTAARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIE 409
+EL +++ E +A + E+ +R +++ E +L+ + +LE + ++ +
Sbjct: 935 QELE---LVVSELEARVGEEEECSR-------QMQTEKKRLQQHIQELEAHLEAEEGARQ 984
Query: 410 ELLEENMVLEIAQKQSMNESAHLGWELEQLSKNADLSDASRKSFVFELNECASSRILKLE 469
+L E + E K+ + L + +LSK L + F + E ++ L
Sbjct: 985 KLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAE-EEEKVKSLN 1043
Query: 470 KENQSLQSTIQGLRDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLET 529
K ++TI + D L EE G + ELEK +L + +LQ Q+ ++Q ++L
Sbjct: 1044 KLRLKYEATIADMEDR-LRKEEKGRQ--ELEKLKRRLDGESSELQEQMVEQQQRAEELRA 1100
Query: 530 LSEELIREKEQLQSDMETLKAD---KARQIKDLEQEKDHLNRAMWSLRER--SQVSSEAR 584
+L R++E+LQ+ + + + +A+ +K L + + L A L ++ +E +
Sbjct: 1101 ---QLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQ 1157
Query: 585 MKDVEKENKALH---QTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQ 641
+D+ +E +AL + ++ +L ++ Q +L++ E+ R E +Q L+
Sbjct: 1158 RRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIH--EAAVQELR 1215
Query: 642 EENGR-LARKVTSLETATEKVEALEHESQGLQLENRTLRKSLDTLQN-----------VS 689
+ +G+ L LE A A E L+ E LR L +LQ +
Sbjct: 1216 QRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLE 1275
Query: 690 LQLE---GLERDNKQLDAENLE-LRRLVETMRFTSTKLAQMERENQQLEREKEELRKNVD 745
LQL+ G D ++ AE E L+R + S L + E + +L +E +
Sbjct: 1276 LQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLH 1335
Query: 746 LLKALGKKSERLELSYQS----VSAENLRLQQSLESSSHKTQTLESELGELEAERQALRR 801
+ L ++ R +L+ S + AE L++ LE + + EL +A+ RR
Sbjct: 1336 DAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRR 1395
Query: 802 DLE----ALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQQVELKDAVLDD 857
E AL A ++ +AL Q +A+ + LE+ +RL Q+++ L+
Sbjct: 1396 RQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQ 1455
Query: 858 STAKLSAVEKESRALDKELARCRDAAGKLKELEKDNRDLTKQVTVHARTLTTLR----ED 913
+S +EK+ R D+ LA + A L+ +E+ R + AR L+ R E
Sbjct: 1456 QRQLVSTLEKKQRKFDQLLA--EEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQ 1513
Query: 914 LVLEKLKSQQ--LSSELDKLSQELEKVG-----LNRELLLQEDDSGSDTKYKILEGRNES 966
E+L+ Q L +EL+ L + VG L R + E + +D + ++ E +E
Sbjct: 1514 EAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAE-QAANDLRAQVTELEDEL 1572
Query: 967 ALK---------TTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLKKECETLRQNQ--- 1014
T A+K + L+ + E RQL +L+ + E + R+ +
Sbjct: 1573 TAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLA 1632
Query: 1015 -GEGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEATMELLRVKDRAIELERNNAALQAEK 1073
+ L+ + + A++ QGKE EA +L +++ + EL R + +
Sbjct: 1633 VAARKKLEGELEELKAQMASAGQGKE-------EAVKQLRKMQAQMKELWREVEETRTSR 1685
Query: 1074 QLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQSAALT 1133
+ + Q + E + +++L LQ++ A Q ++ E + + AA+
Sbjct: 1686 EEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAIL 1745
Query: 1134 AQYTLLQNHHTAKETENESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHS 1193
+ L+ E E E Q E L Y LL E L T SAE + S
Sbjct: 1746 EEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTT---ELSAERSFSAKAES 1802
Query: 1194 CLKTLHRNLELEHKELGERH-GDMLKRKAELEEREKVLTTEREALQQEQR----TNALAM 1248
+ L R ++ LGE G + K + E L E L+QE R + L
Sbjct: 1803 GRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVR 1862
Query: 1249 GENQRLRG---ELDRVNFLHHQLKGEYEELHAHTKELKTSLNNAQLELNRWQA------- 1298
+RL+ +++ + QL+ + E+ + K+LK L A+ E +R QA
Sbjct: 1863 RAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQR 1922
Query: 1299 RFDELKEQHQTMDISLTKLDN 1319
+++ E ++M+ +T L N
Sbjct: 1923 ELEDVTESAESMNREVTTLRN 1943
Score = 148 bits (374), Expect = 5e-35
Identities = 244/1048 (23%), Positives = 439/1048 (41%), Gaps = 136/1048 (12%)
Query: 158 HIQEV-THNQENVFDLQWLELPDVAPEELEALSRSMVLHLRRLIDQRDECTELIVDLTQE 216
HIQE+ H + Q L+L V E A + L L DQ + L++E
Sbjct: 968 HIQELEAHLEAEEGARQKLQLEKVTTE---AKMKKFEEDLLLLEDQNSK-------LSKE 1017
Query: 217 RDYLQAQHPPSPIKSSSADSTPSPTSSLSSEDKQHLAVELADTKARLRRV---RQELE-- 271
R L+ + SS A SL+ ++ A +AD + RLR+ RQELE
Sbjct: 1018 RKLLEDRLAEF---SSQAAEEEEKVKSLNKLRLKYEAT-IADMEDRLRKEEKGRQELEKL 1073
Query: 272 ---------DKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSARAYRDELDSLREKA 322
+ EQ+V+ + ++L +L + K+E +Q A ARA DE + +
Sbjct: 1074 KRRLDGESSELQEQMVEQQQRAEELRAQLGR-KEEELQAAL----ARA-EDEGGARAQLL 1127
Query: 323 NRVERLELELTRCKEKLHDVDFYKARMEELREDNIILIET-KAMLEEQLTAARARGDKVH 381
+ + L +E L + + E+ R D +E + LE+ L + A+ +
Sbjct: 1128 KSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRS 1187
Query: 382 ELEKENLQLKSKLHDLELDRDTDKKRIEELLEEN--MVLEIAQKQSMNESAHLGWELEQL 439
+ E+E +LK LE + + ++EL + + + E+A++ WE +L
Sbjct: 1188 KREQEVTELKK---TLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRL 1244
Query: 440 SKNADLSD-ASRKSFVFELNECASSRILKLEKENQSLQ-----------STIQGLRDASL 487
+ A++S+ + S + + R +LE + Q +Q + L+ A
Sbjct: 1245 ALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQA 1304
Query: 488 VLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSDMET 547
LE E E + +LSK++ + QL D + L +E R K L S +
Sbjct: 1305 ELENVSGALNEAESKTIRLSKELSSTEAQL-------HDAQELLQEETRAKLALGSRVRA 1357
Query: 548 LKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVE----------------KE 591
++A+ A + LE+E RA L+ SE R + E +E
Sbjct: 1358 MEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAARE 1417
Query: 592 NKALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEE-NGRLARK 650
+AL Q + E + +LE +R+L ++L+ A E+ +L L++ Q + + LA +
Sbjct: 1418 AEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEE 1477
Query: 651 VTSLETATEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELR 710
++ A E+ E E E + + +L ++L+ Q E LER N+ L A EL
Sbjct: 1478 KAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAR---EELERQNRALRA---ELE 1531
Query: 711 RLVETMRFTSTKLAQMERENQQLEREKEELRKNV----DLLKALGKKSERLELSYQSVSA 766
L+ + + ++ER + E+ +LR V D L A RLE++ Q++
Sbjct: 1532 ALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKT 1591
Query: 767 ENLR-LQQSLESSSHKTQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKA--- 822
++ R LQ E+ + + L +L + E ER R+ A +LEG ++ KA
Sbjct: 1592 QHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMA 1651
Query: 823 -----LEQEVAQLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELA 877
E+ V QL K ++ + K LW++VE ++ ++ EK + L+ E+
Sbjct: 1652 SAGQGKEEAVKQLRK----MQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVL 1707
Query: 878 RCRD---AAGKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQE 934
R ++ A+ + + + +RD + L + +LE + +QL L +L +E
Sbjct: 1708 RLQEELAASDRARRQAQQDRDEMADEVANG----NLSKAAILE--EKRQLEGRLGQLEEE 1761
Query: 935 LEKVGLNRELLLQEDDSGSDTKYKILEGRNESALKTTLAMKEEKIVLLEAQMEEKASLNR 994
LE+ N ELL + +Y+ L + ES L ++ + S +
Sbjct: 1762 LEEEQSNSELL--------NDRYRKLLLQVES---------------LTTELSAERSFSA 1798
Query: 995 QLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEATMELLR 1054
+ ES Q L+++ + LR GE + +H A + +A +E +L
Sbjct: 1799 KAESGRQQLERQIQELRGRLGE-EDAGARARHKMTIAALESKLAQAEEQLEQETRERILS 1857
Query: 1055 VK-DRAIELERNNAALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEHNTTLQT 1113
K R E LQ E++ + L Q + ++ L++Q +E + Q
Sbjct: 1858 GKLVRRAEKRLKEVVLQVEEE--RRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQA 1915
Query: 1114 QTAKLQVENSTLSSQSAALTAQYTLLQN 1141
+LQ E ++ + ++ + T L+N
Sbjct: 1916 GRRRLQRELEDVTESAESMNREVTTLRN 1943
Score = 133 bits (335), Expect = 2e-30
Identities = 219/1034 (21%), Positives = 414/1034 (40%), Gaps = 130/1034 (12%)
Query: 465 ILKLEKENQSLQSTIQGLRDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQ-- 522
+L++ ++++ LQ+ Q L+ + ++S + GEL+ QL ++ +L QL E +
Sbjct: 861 LLQVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELC 920
Query: 523 ------------SNQDLETLSEEL---IREKEQLQSDMETLKADKARQIKDLEQEKDHLN 567
Q+LE + EL + E+E+ M+T K + I++LE +
Sbjct: 921 AEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEE 980
Query: 568 RAMWSLRERSQVSSEARMKDVE--------------KENKALHQTVTEANGKLSQLEFEK 613
A L + +V++EA+MK E KE K L + E + + ++ E +
Sbjct: 981 GARQKL-QLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKV 1039
Query: 614 RQLHR----------DLE---QAKEKG-ERAEKLEREL---------------QRLQEEN 644
+ L++ D+E + +EKG + EKL+R L QR +E
Sbjct: 1040 KSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELR 1099
Query: 645 GRLARKVTSLETATEKVE----ALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNK 700
+L RK L+ A + E A + L+ L ++ + L++ + E+ +
Sbjct: 1100 AQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRR 1159
Query: 701 QLDAENLELR-RLVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLEL 759
L E LR L +T+ T+ + + Q++ K+ L + + +A ++ +
Sbjct: 1160 DLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHG 1219
Query: 760 SYQSVSAENLRLQQSLESSSHKTQ-TLESELGELEAERQALRRDLEALRLANAQLEGAEK 818
AE L + + + KT+ LE+E+ EL AE +L+ A+ EG E+
Sbjct: 1220 QALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQ---------TARQEG-EQ 1269
Query: 819 DRKALEQEVAQLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKEL-- 876
R+ LE ++ +++ E+ ++++ A L++ + L+ E ++ L KEL
Sbjct: 1270 RRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSS 1329
Query: 877 --ARCRDAAGKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQE 934
A+ DA L+E + L +V LRE L E ++ EL +
Sbjct: 1330 TEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQ 1389
Query: 935 LEKVGLNRELLLQEDDSGSDTKYKILEGRNESALKTTLAMKEEKIVLLEAQMEEKASLNR 994
L + +E ++G + + + R AL LA K E + LE + L +
Sbjct: 1390 LSEWRRRQEEEAGALEAGEEARRR--AAREAEALTQRLAEKTETVDRLE---RGRRRLQQ 1444
Query: 995 QLES---ELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEATME 1051
+L+ +L+ ++ TL + Q + L K + + EA G + +
Sbjct: 1445 ELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALS 1504
Query: 1052 LLRV----KDRAIELERNNAALQAEKQLL-------KEQLQHLETQNVTFSSQILTLQKQ 1100
L R ++ ELER N AL+AE + L + + LE L+ Q
Sbjct: 1505 LTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQ 1564
Query: 1101 SAFLQEHNTTLQTQTAKLQVENSTLSSQ--------SAALTAQYTLLQNHHTAKETENES 1152
L++ T + +L+V L +Q A + L E E +
Sbjct: 1565 VTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDE 1624
Query: 1153 LQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGER 1212
++Q+ AA + L + E L E ++Q ++ + L E +E
Sbjct: 1625 ERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTS 1684
Query: 1213 HGDMLKRKAELEEREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQLKGEY 1272
++ + E E+R K L E LQ+E LA + R + + DR G
Sbjct: 1685 REEIFSQNRESEKRLKGLEAEVLRLQEE-----LAASDRARRQAQQDRDEMADEVANGNL 1739
Query: 1273 EE--LHAHTKELKTSLNNAQLELNRWQARFDELKEQHQTMDISLTKLDNHCELLSRLKGN 1330
+ + ++L+ L + EL Q+ + L ++++ + + + L
Sbjct: 1740 SKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAK 1799
Query: 1331 LEEENHHLLSQIQLL----------SQQNQMLLEQNMENK-----EQYHEEQKQYIDKLN 1375
E L QIQ L ++ + +E+K EQ +E ++ I
Sbjct: 1800 AESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGK 1859
Query: 1376 ALRRHKEKLEEKIM 1389
+RR +++L+E ++
Sbjct: 1860 LVRRAEKRLKEVVL 1873
Score = 113 bits (282), Expect = 2e-24
Identities = 197/890 (22%), Positives = 346/890 (38%), Gaps = 143/890 (16%)
Query: 133 QCERKEEFIERIKQLDIETQAGIVAHIQEVTHNQENVFDLQWLELPDVAPEELEALSRSM 192
Q +R EE ++ + + E QA + E + + L+ E E E L
Sbjct: 1091 QQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLR--EAQAALAEAQEDLESER 1148
Query: 193 VLHLRRLIDQRDECTELIVDLTQERDYLQAQHPPSPIKSSSADSTPSPTSSLSSEDKQHL 252
V + +RD EL + D L + + ++S +L E + H
Sbjct: 1149 VARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHE 1208
Query: 253 AV-------------ELADTKARLRRVR--------------QELEDKTEQLVDTRHEVD 285
A ELA+ + RR + EL + L R E +
Sbjct: 1209 AAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGE 1268
Query: 286 QLVLELQKVKQENIQLAADARSARAYRDELDSLREKANRVERLELELTRCKEKLHDVDFY 345
Q L+ QE A D ARA E A +++R + EL L++ +
Sbjct: 1269 QRRRRLELQLQEVQGRAGDGERARA---------EAAEKLQRAQAELENVSGALNEAESK 1319
Query: 346 KARM-EELREDNIILIETKAMLEEQLTAARARGDKVHELEKENLQLKSKLHDLELDRDTD 404
R+ +EL L + + +L+E+ A A G +V +E E L+ +L + R+
Sbjct: 1320 TIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERA 1379
Query: 405 KKRIEELL-----------EENMVLEI---AQKQSMNESAHLGWELEQLSKNADLSDASR 450
+ ++ EE LE A++++ E+ L L + ++ D + R
Sbjct: 1380 GRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGR 1439
Query: 451 KSFVFELNECASSR------ILKLEKENQSLQSTIQGLRDASL----------------- 487
+ EL++ + LEK+ + + + A L
Sbjct: 1440 RRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGRERE 1499
Query: 488 --------VLEESGLKCGELEKENHQLSKKIEKLQT----------QLERE----KQSNQ 525
LEE ELE++N L ++E L + +LER +Q+
Sbjct: 1500 ARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAAN 1559
Query: 526 DLETLSEELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARM 585
DL EL E E ++ L+ + Q + E+D R R Q++ + R
Sbjct: 1560 DLRAQVTEL--EDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRD 1617
Query: 586 KDVEKENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENG 645
+VE++ + +T+ A K +LE E +L + A G+ E+ ++L+++Q +
Sbjct: 1618 AEVERDEERKQRTLAVAARK--KLEGELEELKAQMASA---GQGKEEAVKQLRKMQAQMK 1672
Query: 646 RLARKVTSLETATEKVEALEHESQ----GLQLENRTLRKSLDTLQNVSLQLEGLERDNKQ 701
L R+V T+ E++ + ES+ GL+ E L++ L Q + +RD
Sbjct: 1673 ELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQ-DRDEMA 1731
Query: 702 LDAENLELRR--LVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLEL 759
+ N L + ++E R Q+E QLE E EE + N +LL + +L L
Sbjct: 1732 DEVANGNLSKAAILEEKR-------QLEGRLGQLEEELEEEQSNSELLN---DRYRKLLL 1781
Query: 760 SYQSVSAE-------NLRLQQSLESSSHKTQTLESELGELEAERQALRR-DLEALRLANA 811
+S++ E + + + + + Q L LGE +A +A + + AL A
Sbjct: 1782 QVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLA 1841
Query: 812 QLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQ---QVELKDAVLDDSTAKLSAVEKE 868
Q E + LEQE + KL+ + KRL + QVE + V D +L
Sbjct: 1842 QAE------EQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLR 1895
Query: 869 SRALDKELARCRDAAGKL----KELEKDNRDLTKQVTVHARTLTTLREDL 914
+ L ++L + A + + L+++ D+T+ R +TTLR L
Sbjct: 1896 VKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRL 1945
Score = 108 bits (270), Expect = 5e-23
Identities = 181/821 (22%), Positives = 338/821 (41%), Gaps = 86/821 (10%)
Query: 618 RDLEQAKEKGERAEKLERELQRLQEENGRLARKVTSLETATEKVEALEHESQGLQLENRT 677
+ L Q + E + +ELQ++QE + AR+V L + + QLE
Sbjct: 859 KPLLQVTRQDEVLQARAQELQKVQELQQQSAREVGEL------------QGRVAQLEEER 906
Query: 678 LRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVETMRFTSTKLAQMERENQQLEREK 737
R + L E E +L A EL +V + ++ + E ++Q++ EK
Sbjct: 907 ARLAEQLRAEAELCAEA-EETRGRLAARKQELELVVSEL---EARVGEEEECSRQMQTEK 962
Query: 738 EELRKNVDLLKA--LGKKSERLELSYQSVSAEN---------LRLQQSLESSSHKTQTLE 786
+ L++++ L+A ++ R +L + V+ E L L+ S + + LE
Sbjct: 963 KRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLE 1022
Query: 787 SELGELE---AERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQ-LEKDKKLLEKEAK 842
L E AE + + L LRL +DR E++ Q LEK K+ L+ E+
Sbjct: 1023 DRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESS 1082
Query: 843 RLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDNRDLTKQVTV 902
L +Q+ + ++ A+L E+E L LAR D G +L K R+ +
Sbjct: 1083 ELQEQMVEQQQRAEELRAQLGRKEEE---LQAALARAEDEGGARAQLLKSLREAQAALAE 1139
Query: 903 HARTLTTLREDLVLEKLKSQQLSSELDKLSQELE----KVGLNRELLLQEDDSGSDTKYK 958
L + R + + + L EL+ L ELE +EL + + ++ K K
Sbjct: 1140 AQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELK-K 1198
Query: 959 ILEGR---NESALKTTLAMKEEKIVLLEAQME---------EKASLNRQLESELQMLKKE 1006
LE +E+A++ + + L Q+E EK L LE+E+ L+ E
Sbjct: 1199 TLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRL--ALEAEVSELRAE 1256
Query: 1007 CETLRQNQGEGQ----HLQNSFKHPAGKTAASHQGKEAWGPGHKEATMELLRV------- 1055
+L+ + EG+ L+ + G+ + + + A EL V
Sbjct: 1257 LSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEA 1316
Query: 1056 KDRAIELERNNAALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEHNTTLQTQT 1115
+ + I L + ++ +A+ +E LQ + S++ ++ ++A L+E L+ +
Sbjct: 1317 ESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQ---LEEEA 1373
Query: 1116 AKLQVENSTLSSQSAALTAQYTLLQNHHTAKETENESLQRQQEQLTAAYEALLQDHEHLG 1175
A + L + A L+ + A E E+ +R + A + L + E +
Sbjct: 1374 AARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVD 1433
Query: 1176 TLHE-RQSAEYEA------LIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAELEEREK 1228
L R+ + E L +Q + TL + + L E +L+ +EERE+
Sbjct: 1434 RLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLR---AVEERER 1490
Query: 1229 VLTTEREALQQEQRTNAL--AMGENQRLRGELDRVNFLHHQLKGEYEELHAHTKELKTSL 1286
E E ++E R +L A+ E Q R EL+R N L+ E E L + ++ S+
Sbjct: 1491 ---AEAEGREREARALSLTRALEEEQEAREELERQN---RALRAELEALLSSKDDVGKSV 1544
Query: 1287 NNAQLELNRWQARFDELKEQHQTMDISLTKL-DNHCELLSRLKGNLEEENHHLLSQIQLL 1345
+ + + ++L+ Q ++ LT D L ++ + L + +
Sbjct: 1545 HELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAG 1604
Query: 1346 SQQNQMLLEQNMENKEQYHEEQKQYIDKLNALRRHKEKLEE 1386
++ + L +Q + + + EE+KQ + A ++ + +LEE
Sbjct: 1605 EERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEE 1645
Score = 92.0 bits (227), Expect = 5e-18
Identities = 142/621 (22%), Positives = 261/621 (42%), Gaps = 81/621 (13%)
Query: 264 RRVRQELEDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSARAYRDELDSLREKAN 323
RR +E E T++L + VD+L ++++QE D R L+ + K +
Sbjct: 1412 RRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFD 1471
Query: 324 RV--ERLELELTRCKEKLHDVDFYKARMEELREDNIILIETKAMLEEQLTAARARGDKVH 381
++ E L +E+ +A E + L T+A+ EEQ +
Sbjct: 1472 QLLAEEKAAVLRAVEER------ERAEAEGREREARALSLTRALEEEQ--------EARE 1517
Query: 382 ELEKENLQLKSKLHDLELDRDTDKKRIEELLEENMVLEIAQKQSMNESAHLGWELEQLSK 441
ELE++N L+++L L ++ K + +S H ELE+ +
Sbjct: 1518 ELERQNRALRAELEAL----------------------LSSKDDVGKSVH---ELERACR 1552
Query: 442 NADLSDASRKSFVFELNE---CASSRILKLEKENQSLQSTIQGLRDASLVLEESGLKCGE 498
A+ + ++ V EL + A L+LE Q+L++ Q RD +E+G
Sbjct: 1553 VAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKT--QHERDLQ-GRDEAG----- 1604
Query: 499 LEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSDMETLKADKARQIKD 558
E+ QL+K++ + + + E++ ++L E E+L++ M + K +K
Sbjct: 1605 -EERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQ 1663
Query: 559 LEQEKDHLNRAMWSLRERSQVSSE---ARMKDVEKENKALHQTVTEANGKLSQLEFEKRQ 615
L + + + + +W E ++ S E ++ ++ EK K L V +L+ + +RQ
Sbjct: 1664 LRKMQAQM-KELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQ 1722
Query: 616 LHRDL-EQAKEKGERAEKLERELQRLQEENGRLARKVTSLETATEKVEALEHESQGLQLE 674
+D E A E L+ ++ GRL + LE E L + L L+
Sbjct: 1723 AQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQ 1782
Query: 675 NRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELR-RLVE-----------TMRFTSTK 722
+L L ++ S + E +QL+ + ELR RL E T+ +K
Sbjct: 1783 VESLTTELSAERSFSAKAES---GRQQLERQIQELRGRLGEEDAGARARHKMTIAALESK 1839
Query: 723 LAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSSHKT 782
LAQ E +QLE+E E + L++ K+ + + L + +L+ LE + +
Sbjct: 1840 LAQAE---EQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRV 1896
Query: 783 QTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKL--LEKE 840
+ L+ +L EAE +A R RL +LE + +++ +EV L + L
Sbjct: 1897 KQLKRQLE--EAEEEASRAQAGRRRL-QRELEDVTESAESMNREVTTLRNRLRRGPLTFT 1953
Query: 841 AKRLWQQVELKDAVLDDSTAK 861
+ + Q L++ V D A+
Sbjct: 1954 TRTVRQVFRLEEGVASDEEAE 1974
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 170 bits (431), Expect = 1e-41
Identities = 253/1101 (22%), Positives = 464/1101 (42%), Gaps = 105/1101 (9%)
Query: 290 ELQKVKQENIQLAADARSARAYRDELDSLREKANRVERLELELTRCKEKLHDVDFYKARM 349
ELQKV++ Q A + + +L+ E+A E+L E C E AR
Sbjct: 918 ELQKVQELQQQSAREVGELQGRVAQLEE--ERARLAEQLRAEAELCAEAEETRGRLAARK 975
Query: 350 EELREDNIILIETKAMLEEQLTAARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIE 409
+EL +++ E +A + E+ +R +++ E +L+ + +LE + ++ +
Sbjct: 976 QELE---LVVSELEARVGEEEECSR-------QMQTEKKRLQQHIQELEAHLEAEEGARQ 1025
Query: 410 ELLEENMVLEIAQKQSMNESAHLGWELEQLSKNADLSDASRKSFVFELNECASSRILKLE 469
+L E + E K+ + L + +LSK L + F + E ++ L
Sbjct: 1026 KLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAE-EEEKVKSLN 1084
Query: 470 KENQSLQSTIQGLRDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLET 529
K ++TI + D L EE G + ELEK +L + +LQ Q+ ++Q ++L
Sbjct: 1085 KLRLKYEATIADMEDR-LRKEEKGRQ--ELEKLKRRLDGESSELQEQMVEQQQRAEELRA 1141
Query: 530 LSEELIREKEQLQSDMETLKAD---KARQIKDLEQEKDHLNRAMWSLRER--SQVSSEAR 584
+L R++E+LQ+ + + + +A+ +K L + + L A L ++ +E +
Sbjct: 1142 ---QLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQ 1198
Query: 585 MKDVEKENKALH---QTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQ 641
+D+ +E +AL + ++ +L ++ Q +L++ E+ R E +Q L+
Sbjct: 1199 RRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIH--EAAVQELR 1256
Query: 642 EENGR-LARKVTSLETATEKVEALEHESQGLQLENRTLRKSLDTLQN-----------VS 689
+ +G+ L LE A A E L+ E LR L +LQ +
Sbjct: 1257 QRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLE 1316
Query: 690 LQLE---GLERDNKQLDAENLE-LRRLVETMRFTSTKLAQMERENQQLEREKEELRKNVD 745
LQL+ G D ++ AE E L+R + S L + E + +L +E +
Sbjct: 1317 LQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLH 1376
Query: 746 LLKALGKKSERLELSYQS----VSAENLRLQQSLESSSHKTQTLESELGELEAERQALRR 801
+ L ++ R +L+ S + AE L++ LE + + EL +A+ RR
Sbjct: 1377 DAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRR 1436
Query: 802 DLE----ALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQQVELKDAVLDD 857
E AL A ++ +AL Q +A+ + LE+ +RL Q+++ L+
Sbjct: 1437 RQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQ 1496
Query: 858 STAKLSAVEKESRALDKELARCRDAAGKLKELEKDNRDLTKQVTVHARTLTTLR----ED 913
+S +EK+ R D+ LA + A L+ +E+ R + AR L+ R E
Sbjct: 1497 QRQLVSTLEKKQRKFDQLLA--EEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQ 1554
Query: 914 LVLEKLKSQQ--LSSELDKLSQELEKVG-----LNRELLLQEDDSGSDTKYKILEGRNES 966
E+L+ Q L +EL+ L + VG L R + E + +D + ++ E +E
Sbjct: 1555 EAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAE-QAANDLRAQVTELEDEL 1613
Query: 967 ALK---------TTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLKKECETLRQNQ--- 1014
T A+K + L+ + E RQL +L+ + E + R+ +
Sbjct: 1614 TAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLA 1673
Query: 1015 -GEGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEATMELLRVKDRAIELERNNAALQAEK 1073
+ L+ + + A++ QGKE EA +L +++ + EL R + +
Sbjct: 1674 VAARKKLEGELEELKAQMASAGQGKE-------EAVKQLRKMQAQMKELWREVEETRTSR 1726
Query: 1074 QLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQSAALT 1133
+ + Q + E + +++L LQ++ A Q ++ E + + AA+
Sbjct: 1727 EEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAIL 1786
Query: 1134 AQYTLLQNHHTAKETENESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHS 1193
+ L+ E E E Q E L Y LL E L T SAE + S
Sbjct: 1787 EEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTT---ELSAERSFSAKAES 1843
Query: 1194 CLKTLHRNLELEHKELGERH-GDMLKRKAELEEREKVLTTEREALQQEQR----TNALAM 1248
+ L R ++ LGE G + K + E L E L+QE R + L
Sbjct: 1844 GRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVR 1903
Query: 1249 GENQRLRG---ELDRVNFLHHQLKGEYEELHAHTKELKTSLNNAQLELNRWQA------- 1298
+RL+ +++ + QL+ + E+ + K+LK L A+ E +R QA
Sbjct: 1904 RAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQR 1963
Query: 1299 RFDELKEQHQTMDISLTKLDN 1319
+++ E ++M+ +T L N
Sbjct: 1964 ELEDVTESAESMNREVTTLRN 1984
Score = 148 bits (374), Expect = 5e-35
Identities = 244/1048 (23%), Positives = 439/1048 (41%), Gaps = 136/1048 (12%)
Query: 158 HIQEV-THNQENVFDLQWLELPDVAPEELEALSRSMVLHLRRLIDQRDECTELIVDLTQE 216
HIQE+ H + Q L+L V E A + L L DQ + L++E
Sbjct: 1009 HIQELEAHLEAEEGARQKLQLEKVTTE---AKMKKFEEDLLLLEDQNSK-------LSKE 1058
Query: 217 RDYLQAQHPPSPIKSSSADSTPSPTSSLSSEDKQHLAVELADTKARLRRV---RQELE-- 271
R L+ + SS A SL+ ++ A +AD + RLR+ RQELE
Sbjct: 1059 RKLLEDRLAEF---SSQAAEEEEKVKSLNKLRLKYEAT-IADMEDRLRKEEKGRQELEKL 1114
Query: 272 ---------DKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSARAYRDELDSLREKA 322
+ EQ+V+ + ++L +L + K+E +Q A ARA DE + +
Sbjct: 1115 KRRLDGESSELQEQMVEQQQRAEELRAQLGR-KEEELQAAL----ARA-EDEGGARAQLL 1168
Query: 323 NRVERLELELTRCKEKLHDVDFYKARMEELREDNIILIET-KAMLEEQLTAARARGDKVH 381
+ + L +E L + + E+ R D +E + LE+ L + A+ +
Sbjct: 1169 KSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRS 1228
Query: 382 ELEKENLQLKSKLHDLELDRDTDKKRIEELLEEN--MVLEIAQKQSMNESAHLGWELEQL 439
+ E+E +LK LE + + ++EL + + + E+A++ WE +L
Sbjct: 1229 KREQEVTELKK---TLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRL 1285
Query: 440 SKNADLSD-ASRKSFVFELNECASSRILKLEKENQSLQ-----------STIQGLRDASL 487
+ A++S+ + S + + R +LE + Q +Q + L+ A
Sbjct: 1286 ALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQA 1345
Query: 488 VLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSDMET 547
LE E E + +LSK++ + QL D + L +E R K L S +
Sbjct: 1346 ELENVSGALNEAESKTIRLSKELSSTEAQL-------HDAQELLQEETRAKLALGSRVRA 1398
Query: 548 LKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVE----------------KE 591
++A+ A + LE+E RA L+ SE R + E +E
Sbjct: 1399 MEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAARE 1458
Query: 592 NKALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEE-NGRLARK 650
+AL Q + E + +LE +R+L ++L+ A E+ +L L++ Q + + LA +
Sbjct: 1459 AEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEE 1518
Query: 651 VTSLETATEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELR 710
++ A E+ E E E + + +L ++L+ Q E LER N+ L A EL
Sbjct: 1519 KAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAR---EELERQNRALRA---ELE 1572
Query: 711 RLVETMRFTSTKLAQMERENQQLEREKEELRKNV----DLLKALGKKSERLELSYQSVSA 766
L+ + + ++ER + E+ +LR V D L A RLE++ Q++
Sbjct: 1573 ALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKT 1632
Query: 767 ENLR-LQQSLESSSHKTQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKA--- 822
++ R LQ E+ + + L +L + E ER R+ A +LEG ++ KA
Sbjct: 1633 QHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMA 1692
Query: 823 -----LEQEVAQLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELA 877
E+ V QL K ++ + K LW++VE ++ ++ EK + L+ E+
Sbjct: 1693 SAGQGKEEAVKQLRK----MQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVL 1748
Query: 878 RCRD---AAGKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQE 934
R ++ A+ + + + +RD + L + +LE + +QL L +L +E
Sbjct: 1749 RLQEELAASDRARRQAQQDRDEMADEVANG----NLSKAAILE--EKRQLEGRLGQLEEE 1802
Query: 935 LEKVGLNRELLLQEDDSGSDTKYKILEGRNESALKTTLAMKEEKIVLLEAQMEEKASLNR 994
LE+ N ELL + +Y+ L + ES L ++ + S +
Sbjct: 1803 LEEEQSNSELL--------NDRYRKLLLQVES---------------LTTELSAERSFSA 1839
Query: 995 QLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEATMELLR 1054
+ ES Q L+++ + LR GE + +H A + +A +E +L
Sbjct: 1840 KAESGRQQLERQIQELRGRLGE-EDAGARARHKMTIAALESKLAQAEEQLEQETRERILS 1898
Query: 1055 VK-DRAIELERNNAALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEHNTTLQT 1113
K R E LQ E++ + L Q + ++ L++Q +E + Q
Sbjct: 1899 GKLVRRAEKRLKEVVLQVEEE--RRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQA 1956
Query: 1114 QTAKLQVENSTLSSQSAALTAQYTLLQN 1141
+LQ E ++ + ++ + T L+N
Sbjct: 1957 GRRRLQRELEDVTESAESMNREVTTLRN 1984
Score = 133 bits (335), Expect = 2e-30
Identities = 219/1034 (21%), Positives = 414/1034 (40%), Gaps = 130/1034 (12%)
Query: 465 ILKLEKENQSLQSTIQGLRDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQ-- 522
+L++ ++++ LQ+ Q L+ + ++S + GEL+ QL ++ +L QL E +
Sbjct: 902 LLQVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELC 961
Query: 523 ------------SNQDLETLSEEL---IREKEQLQSDMETLKADKARQIKDLEQEKDHLN 567
Q+LE + EL + E+E+ M+T K + I++LE +
Sbjct: 962 AEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEE 1021
Query: 568 RAMWSLRERSQVSSEARMKDVE--------------KENKALHQTVTEANGKLSQLEFEK 613
A L + +V++EA+MK E KE K L + E + + ++ E +
Sbjct: 1022 GARQKL-QLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKV 1080
Query: 614 RQLHR----------DLE---QAKEKG-ERAEKLEREL---------------QRLQEEN 644
+ L++ D+E + +EKG + EKL+R L QR +E
Sbjct: 1081 KSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELR 1140
Query: 645 GRLARKVTSLETATEKVE----ALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNK 700
+L RK L+ A + E A + L+ L ++ + L++ + E+ +
Sbjct: 1141 AQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRR 1200
Query: 701 QLDAENLELR-RLVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLEL 759
L E LR L +T+ T+ + + Q++ K+ L + + +A ++ +
Sbjct: 1201 DLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHG 1260
Query: 760 SYQSVSAENLRLQQSLESSSHKTQ-TLESELGELEAERQALRRDLEALRLANAQLEGAEK 818
AE L + + + KT+ LE+E+ EL AE +L+ A+ EG E+
Sbjct: 1261 QALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQ---------TARQEG-EQ 1310
Query: 819 DRKALEQEVAQLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKEL-- 876
R+ LE ++ +++ E+ ++++ A L++ + L+ E ++ L KEL
Sbjct: 1311 RRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSS 1370
Query: 877 --ARCRDAAGKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQE 934
A+ DA L+E + L +V LRE L E ++ EL +
Sbjct: 1371 TEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQ 1430
Query: 935 LEKVGLNRELLLQEDDSGSDTKYKILEGRNESALKTTLAMKEEKIVLLEAQMEEKASLNR 994
L + +E ++G + + + R AL LA K E + LE + L +
Sbjct: 1431 LSEWRRRQEEEAGALEAGEEARRR--AAREAEALTQRLAEKTETVDRLE---RGRRRLQQ 1485
Query: 995 QLES---ELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEATME 1051
+L+ +L+ ++ TL + Q + L K + + EA G + +
Sbjct: 1486 ELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALS 1545
Query: 1052 LLRV----KDRAIELERNNAALQAEKQLL-------KEQLQHLETQNVTFSSQILTLQKQ 1100
L R ++ ELER N AL+AE + L + + LE L+ Q
Sbjct: 1546 LTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQ 1605
Query: 1101 SAFLQEHNTTLQTQTAKLQVENSTLSSQ--------SAALTAQYTLLQNHHTAKETENES 1152
L++ T + +L+V L +Q A + L E E +
Sbjct: 1606 VTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDE 1665
Query: 1153 LQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGER 1212
++Q+ AA + L + E L E ++Q ++ + L E +E
Sbjct: 1666 ERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTS 1725
Query: 1213 HGDMLKRKAELEEREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQLKGEY 1272
++ + E E+R K L E LQ+E LA + R + + DR G
Sbjct: 1726 REEIFSQNRESEKRLKGLEAEVLRLQEE-----LAASDRARRQAQQDRDEMADEVANGNL 1780
Query: 1273 EE--LHAHTKELKTSLNNAQLELNRWQARFDELKEQHQTMDISLTKLDNHCELLSRLKGN 1330
+ + ++L+ L + EL Q+ + L ++++ + + + L
Sbjct: 1781 SKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAK 1840
Query: 1331 LEEENHHLLSQIQLL----------SQQNQMLLEQNMENK-----EQYHEEQKQYIDKLN 1375
E L QIQ L ++ + +E+K EQ +E ++ I
Sbjct: 1841 AESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGK 1900
Query: 1376 ALRRHKEKLEEKIM 1389
+RR +++L+E ++
Sbjct: 1901 LVRRAEKRLKEVVL 1914
Score = 113 bits (282), Expect = 2e-24
Identities = 197/890 (22%), Positives = 346/890 (38%), Gaps = 143/890 (16%)
Query: 133 QCERKEEFIERIKQLDIETQAGIVAHIQEVTHNQENVFDLQWLELPDVAPEELEALSRSM 192
Q +R EE ++ + + E QA + E + + L+ E E E L
Sbjct: 1132 QQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLR--EAQAALAEAQEDLESER 1189
Query: 193 VLHLRRLIDQRDECTELIVDLTQERDYLQAQHPPSPIKSSSADSTPSPTSSLSSEDKQHL 252
V + +RD EL + D L + + ++S +L E + H
Sbjct: 1190 VARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHE 1249
Query: 253 AV-------------ELADTKARLRRVR--------------QELEDKTEQLVDTRHEVD 285
A ELA+ + RR + EL + L R E +
Sbjct: 1250 AAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGE 1309
Query: 286 QLVLELQKVKQENIQLAADARSARAYRDELDSLREKANRVERLELELTRCKEKLHDVDFY 345
Q L+ QE A D ARA E A +++R + EL L++ +
Sbjct: 1310 QRRRRLELQLQEVQGRAGDGERARA---------EAAEKLQRAQAELENVSGALNEAESK 1360
Query: 346 KARM-EELREDNIILIETKAMLEEQLTAARARGDKVHELEKENLQLKSKLHDLELDRDTD 404
R+ +EL L + + +L+E+ A A G +V +E E L+ +L + R+
Sbjct: 1361 TIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERA 1420
Query: 405 KKRIEELL-----------EENMVLEI---AQKQSMNESAHLGWELEQLSKNADLSDASR 450
+ ++ EE LE A++++ E+ L L + ++ D + R
Sbjct: 1421 GRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGR 1480
Query: 451 KSFVFELNECASSR------ILKLEKENQSLQSTIQGLRDASL----------------- 487
+ EL++ + LEK+ + + + A L
Sbjct: 1481 RRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGRERE 1540
Query: 488 --------VLEESGLKCGELEKENHQLSKKIEKLQT----------QLERE----KQSNQ 525
LEE ELE++N L ++E L + +LER +Q+
Sbjct: 1541 ARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAAN 1600
Query: 526 DLETLSEELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARM 585
DL EL E E ++ L+ + Q + E+D R R Q++ + R
Sbjct: 1601 DLRAQVTEL--EDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRD 1658
Query: 586 KDVEKENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENG 645
+VE++ + +T+ A K +LE E +L + A G+ E+ ++L+++Q +
Sbjct: 1659 AEVERDEERKQRTLAVAARK--KLEGELEELKAQMASA---GQGKEEAVKQLRKMQAQMK 1713
Query: 646 RLARKVTSLETATEKVEALEHESQ----GLQLENRTLRKSLDTLQNVSLQLEGLERDNKQ 701
L R+V T+ E++ + ES+ GL+ E L++ L Q + +RD
Sbjct: 1714 ELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQ-DRDEMA 1772
Query: 702 LDAENLELRR--LVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLEL 759
+ N L + ++E R Q+E QLE E EE + N +LL + +L L
Sbjct: 1773 DEVANGNLSKAAILEEKR-------QLEGRLGQLEEELEEEQSNSELLN---DRYRKLLL 1822
Query: 760 SYQSVSAE-------NLRLQQSLESSSHKTQTLESELGELEAERQALRR-DLEALRLANA 811
+S++ E + + + + + Q L LGE +A +A + + AL A
Sbjct: 1823 QVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLA 1882
Query: 812 QLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQ---QVELKDAVLDDSTAKLSAVEKE 868
Q E + LEQE + KL+ + KRL + QVE + V D +L
Sbjct: 1883 QAE------EQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLR 1936
Query: 869 SRALDKELARCRDAAGKL----KELEKDNRDLTKQVTVHARTLTTLREDL 914
+ L ++L + A + + L+++ D+T+ R +TTLR L
Sbjct: 1937 VKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRL 1986
Score = 108 bits (270), Expect = 5e-23
Identities = 181/821 (22%), Positives = 338/821 (41%), Gaps = 86/821 (10%)
Query: 618 RDLEQAKEKGERAEKLERELQRLQEENGRLARKVTSLETATEKVEALEHESQGLQLENRT 677
+ L Q + E + +ELQ++QE + AR+V L + + QLE
Sbjct: 900 KPLLQVTRQDEVLQARAQELQKVQELQQQSAREVGEL------------QGRVAQLEEER 947
Query: 678 LRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVETMRFTSTKLAQMERENQQLEREK 737
R + L E E +L A EL +V + ++ + E ++Q++ EK
Sbjct: 948 ARLAEQLRAEAELCAEA-EETRGRLAARKQELELVVSEL---EARVGEEEECSRQMQTEK 1003
Query: 738 EELRKNVDLLKA--LGKKSERLELSYQSVSAEN---------LRLQQSLESSSHKTQTLE 786
+ L++++ L+A ++ R +L + V+ E L L+ S + + LE
Sbjct: 1004 KRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLE 1063
Query: 787 SELGELE---AERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQ-LEKDKKLLEKEAK 842
L E AE + + L LRL +DR E++ Q LEK K+ L+ E+
Sbjct: 1064 DRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESS 1123
Query: 843 RLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDNRDLTKQVTV 902
L +Q+ + ++ A+L E+E L LAR D G +L K R+ +
Sbjct: 1124 ELQEQMVEQQQRAEELRAQLGRKEEE---LQAALARAEDEGGARAQLLKSLREAQAALAE 1180
Query: 903 HARTLTTLREDLVLEKLKSQQLSSELDKLSQELE----KVGLNRELLLQEDDSGSDTKYK 958
L + R + + + L EL+ L ELE +EL + + ++ K K
Sbjct: 1181 AQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELK-K 1239
Query: 959 ILEGR---NESALKTTLAMKEEKIVLLEAQME---------EKASLNRQLESELQMLKKE 1006
LE +E+A++ + + L Q+E EK L LE+E+ L+ E
Sbjct: 1240 TLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRL--ALEAEVSELRAE 1297
Query: 1007 CETLRQNQGEGQ----HLQNSFKHPAGKTAASHQGKEAWGPGHKEATMELLRV------- 1055
+L+ + EG+ L+ + G+ + + + A EL V
Sbjct: 1298 LSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEA 1357
Query: 1056 KDRAIELERNNAALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEHNTTLQTQT 1115
+ + I L + ++ +A+ +E LQ + S++ ++ ++A L+E L+ +
Sbjct: 1358 ESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQ---LEEEA 1414
Query: 1116 AKLQVENSTLSSQSAALTAQYTLLQNHHTAKETENESLQRQQEQLTAAYEALLQDHEHLG 1175
A + L + A L+ + A E E+ +R + A + L + E +
Sbjct: 1415 AARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVD 1474
Query: 1176 TLHE-RQSAEYEA------LIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAELEEREK 1228
L R+ + E L +Q + TL + + L E +L+ +EERE+
Sbjct: 1475 RLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLR---AVEERER 1531
Query: 1229 VLTTEREALQQEQRTNAL--AMGENQRLRGELDRVNFLHHQLKGEYEELHAHTKELKTSL 1286
E E ++E R +L A+ E Q R EL+R N L+ E E L + ++ S+
Sbjct: 1532 ---AEAEGREREARALSLTRALEEEQEAREELERQN---RALRAELEALLSSKDDVGKSV 1585
Query: 1287 NNAQLELNRWQARFDELKEQHQTMDISLTKL-DNHCELLSRLKGNLEEENHHLLSQIQLL 1345
+ + + ++L+ Q ++ LT D L ++ + L + +
Sbjct: 1586 HELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAG 1645
Query: 1346 SQQNQMLLEQNMENKEQYHEEQKQYIDKLNALRRHKEKLEE 1386
++ + L +Q + + + EE+KQ + A ++ + +LEE
Sbjct: 1646 EERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEE 1686
Score = 92.0 bits (227), Expect = 5e-18
Identities = 142/621 (22%), Positives = 261/621 (42%), Gaps = 81/621 (13%)
Query: 264 RRVRQELEDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSARAYRDELDSLREKAN 323
RR +E E T++L + VD+L ++++QE D R L+ + K +
Sbjct: 1453 RRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFD 1512
Query: 324 RV--ERLELELTRCKEKLHDVDFYKARMEELREDNIILIETKAMLEEQLTAARARGDKVH 381
++ E L +E+ +A E + L T+A+ EEQ +
Sbjct: 1513 QLLAEEKAAVLRAVEER------ERAEAEGREREARALSLTRALEEEQ--------EARE 1558
Query: 382 ELEKENLQLKSKLHDLELDRDTDKKRIEELLEENMVLEIAQKQSMNESAHLGWELEQLSK 441
ELE++N L+++L L ++ K + +S H ELE+ +
Sbjct: 1559 ELERQNRALRAELEAL----------------------LSSKDDVGKSVH---ELERACR 1593
Query: 442 NADLSDASRKSFVFELNE---CASSRILKLEKENQSLQSTIQGLRDASLVLEESGLKCGE 498
A+ + ++ V EL + A L+LE Q+L++ Q RD +E+G
Sbjct: 1594 VAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKT--QHERDLQ-GRDEAG----- 1645
Query: 499 LEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSDMETLKADKARQIKD 558
E+ QL+K++ + + + E++ ++L E E+L++ M + K +K
Sbjct: 1646 -EERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQ 1704
Query: 559 LEQEKDHLNRAMWSLRERSQVSSE---ARMKDVEKENKALHQTVTEANGKLSQLEFEKRQ 615
L + + + + +W E ++ S E ++ ++ EK K L V +L+ + +RQ
Sbjct: 1705 LRKMQAQM-KELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQ 1763
Query: 616 LHRDL-EQAKEKGERAEKLERELQRLQEENGRLARKVTSLETATEKVEALEHESQGLQLE 674
+D E A E L+ ++ GRL + LE E L + L L+
Sbjct: 1764 AQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQ 1823
Query: 675 NRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELR-RLVE-----------TMRFTSTK 722
+L L ++ S + E +QL+ + ELR RL E T+ +K
Sbjct: 1824 VESLTTELSAERSFSAKAES---GRQQLERQIQELRGRLGEEDAGARARHKMTIAALESK 1880
Query: 723 LAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSSHKT 782
LAQ E +QLE+E E + L++ K+ + + L + +L+ LE + +
Sbjct: 1881 LAQAE---EQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRV 1937
Query: 783 QTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKL--LEKE 840
+ L+ +L EAE +A R RL +LE + +++ +EV L + L
Sbjct: 1938 KQLKRQLE--EAEEEASRAQAGRRRL-QRELEDVTESAESMNREVTTLRNRLRRGPLTFT 1994
Query: 841 AKRLWQQVELKDAVLDDSTAK 861
+ + Q L++ V D A+
Sbjct: 1995 TRTVRQVFRLEEGVASDEEAE 2015
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 170 bits (431), Expect = 1e-41
Identities = 256/1183 (21%), Positives = 496/1183 (41%), Gaps = 181/1183 (15%)
Query: 286 QLVLELQKVKQENIQLAADARSARAYR--DELDSLREKANRVERLEL---ELTRCKEKLH 340
Q L KV Q N R + +R ++ L + + E L+ EL + KEK
Sbjct: 810 QQQLSALKVLQRNCAAYLKLRHWQWWRVFTKVKPLLQVTRQEEELQAKDEELLKVKEKQT 869
Query: 341 DVDFYKARMEELREDNIILIETKAMLEEQLTAARARGDKVHELEKENLQLKSKLHDLELD 400
V+ +EE+ + L+E K +L EQL +A + E E+ +L +K +LE
Sbjct: 870 KVE---GELEEMERKHQQLLEEKNILAEQL---QAETELFAEAEEMRARLAAKKQELEEI 923
Query: 401 RDTDKKRIEELLEENMVLEIAQKQSMNESAHLGWELEQLSKNADLSDASRKSFVFELNEC 460
+ R+EE E N +L+ NE + ++ L + D + +R+ E
Sbjct: 924 LHDLESRVEEEEERNQILQ-------NEKKKMQAHIQDLEEQLDEEEGARQKLQLE-KVT 975
Query: 461 ASSRILKLEKENQSLQSTIQGLRDASLVLEESGLKCGELEKENHQLSKKIEK-------- 512
A ++I K+E+E L+ ++E+ +C E + +K + K
Sbjct: 976 AEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVM 1035
Query: 513 ---LQTQLEREKQSNQDLETLSEELIREKE-------QLQSDMETLKADKARQIKDLE-- 560
L+ +L++E+++ Q+LE +L E +LQ+ ++ LK A++ ++L+
Sbjct: 1036 ISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGA 1095
Query: 561 -----QEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEANGKLSQLEFEKRQ 615
E H N A+ +RE +E + +D E E + ++ + +LE K +
Sbjct: 1096 LARGDDETLHKNNALKVVRELQAQIAELQ-EDFESEKASRNKAEKQKRDLSEELEALKTE 1154
Query: 616 LHRDLEQAKEKGERAEKLERELQRLQ---EENGR---------LARKVTSLETATEKVEA 663
L L+ + E K E+E+ L+ EE + R T+LE +E++E
Sbjct: 1155 LEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQ 1214
Query: 664 -------LEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVETM 716
LE QGL+ +N+ L + LQ V + E K+LDA+ EL
Sbjct: 1215 AKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESE---HKRKKLDAQVQELH------ 1265
Query: 717 RFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQ----SVSAENLRLQ 772
K+++ +R +L + +L+ +D + L +++E+ + + S+ ++ Q
Sbjct: 1266 ----AKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQ 1321
Query: 773 QSLESSSHKTQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEV----A 828
+ L+ + + L S + +LE E+ +L+ Q E E+ RK LE++V +
Sbjct: 1322 ELLQEETRQKLNLSSRIRQLEEEKNSLQE----------QQEEEEEARKNLEKQVLALQS 1371
Query: 829 QLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKE 888
QL KK ++ + + E K +L D+ A +E+++ A DK
Sbjct: 1372 QLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDK-------------- 1417
Query: 889 LEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQE 948
LEK L +++ +DL ++ +Q++S L+K ++ ++ LL E
Sbjct: 1418 LEKTKNRLQQEL-----------DDLTVDLDHQRQVASNLEKKQKKFDQ-------LLAE 1459
Query: 949 DDSGSDTKYKILEGRNESALKTTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLKKECE 1008
+ S S +Y R E+ + KE K + L +EE + E + + L+ + E
Sbjct: 1460 EKSIS-ARYAEERDRAEAEARE----KETKALSLARALEEALEAKEEFERQNKQLRADME 1514
Query: 1009 TLRQNQGE-GQHLQNSFKHPAGKTAASHQGKEAWGPGHKEATMELLRVKDRAIELERNNA 1067
L ++ + G+++ K A Q E +E EL +D + LE N
Sbjct: 1515 DLMSSKDDVGKNVHELEK----SKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQ 1570
Query: 1068 ALQA--EKQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENSTL 1125
A++A E+ L Q+ E + + Q+ L+ + ++ K++++ L
Sbjct: 1571 AMKAQFERDLQTRDEQNEEKKRLLIK-QVRELEAELEDERKQRALAVASKKKMEIDLKDL 1629
Query: 1126 SSQSAALTAQYTLLQNHHTAKETENESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEY 1185
+Q A + + + + QR+ E+ A+ + + + + AE
Sbjct: 1630 EAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEI 1689
Query: 1186 EALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAELEEREKVLTTE----REALQQEQ 1241
L + + + R+ E E EL + + K+ L + ++ L E L++EQ
Sbjct: 1690 LQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQ 1749
Query: 1242 RTNALAMGENQRLRGELDRVNFLHHQLKGEY----------EELHAHTKELKTSLNNAQL 1291
L N R R +V+ L+ +L E ++L KELK L +
Sbjct: 1750 SNMELL---NDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEG 1806
Query: 1292 EL-NRWQARFDELKEQHQTMDISLTKLDNHCELLSRLKGNLEEENHHLLSQIQLLSQQNQ 1350
+ ++++A L+ + + +L+ LE+E + +L+ + +
Sbjct: 1807 AVKSKFKATISALEAK-----------------IGQLEEQLEQEAKERAAANKLVRRTEK 1849
Query: 1351 MLLE--QNMENKEQYHEEQKQYIDKLNA----LRRHKEKLEEK 1387
L E +E++ ++ ++ K+ ++K NA L+R E+ EE+
Sbjct: 1850 KLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEE 1892
Score = 161 bits (408), Expect = 5e-39
Identities = 273/1148 (23%), Positives = 493/1148 (42%), Gaps = 157/1148 (13%)
Query: 262 RLRRVRQELEDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARS-ARAYRDELDSLRE 320
++ R +EL+ K E+L+ + + ++ EL+++++++ QL + A + E + E
Sbjct: 846 QVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAE 905
Query: 321 KANRVERLELELTRCKEKLHDVDFYKARMEELREDNIILIETKAM-------LEEQLTAA 373
RL + +E LHD++ +R+EE E N IL K LEEQL
Sbjct: 906 AEEMRARLAAKKQELEEILHDLE---SRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEE 962
Query: 374 RARGDKVHELEKENLQLKSKLHDLEL----DRDT----DKKRIEELL------------- 412
K+ +LEK + K K + E+ D+++ +KK +E+ +
Sbjct: 963 EGARQKL-QLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEK 1021
Query: 413 ----------EENMVLEIAQKQSMNESAHLGWELEQLSKNADLSDASRKSFVFELNECAS 462
+E M+ ++ ++ E ELE+ + D + + EL
Sbjct: 1022 AKNLAKIRNKQEVMISDLEERLKKEEKTRQ--ELEKAKRKLDGETTDLQDQIAELQAQID 1079
Query: 463 SRILKLEKENQSLQSTIQGLRDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQ 522
L+L K+ + LQ + D +L + K +L +I +LQ E EK
Sbjct: 1080 ELKLQLAKKEEELQGALARGDDETLHKNNA-------LKVVRELQAQIAELQEDFESEKA 1132
Query: 523 SNQDLE----TLSEELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQ 578
S E LSEEL K +L+ ++T A + + K EQE L +A+ E
Sbjct: 1133 SRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTK-REQEVAELKKAL----EEET 1187
Query: 579 VSSEARMKDVEKENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEK-LEREL 637
+ EA+++D+ + + + ++E QLE KR +LE+ K+ E K L E+
Sbjct: 1188 KNHEAQIQDMRQRHATALEELSE------QLEQAKR-FKANLEKNKQGLETDNKELACEV 1240
Query: 638 QRLQEENGRLARKVTSLETATEKVEALEHESQGLQLE-NRTLRKSLDTLQNVSLQLEGLE 696
+ LQ+ K L+ +++ A E L++E K + L NVS LE E
Sbjct: 1241 KVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAE 1300
Query: 697 RDNKQL--DAENLE--LRRLVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGK 752
+ + DA +LE L+ E ++ + + + +QLE EK L++ + + K
Sbjct: 1301 KKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARK 1360
Query: 753 KSERLELSYQSVSAENLRLQQSLESSSHKTQTLESELGELEAERQALRRDLEALRLANAQ 812
E+ L+ QS A+ ++ ++ ++LE +L + +AL + LE LA +
Sbjct: 1361 NLEKQVLALQSQLADT---KKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDK 1417
Query: 813 LEGAEKDRKALEQEVAQLEKD-------KKLLEKEAKRLWQQVELKDAVL-----DDSTA 860
L EK + L+QE+ L D LEK+ K+ Q + + ++ + A
Sbjct: 1418 L---EKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRA 1474
Query: 861 KLSAVEKESRALDKELARCRDAAGKLK-ELEKDNRDLTKQVTVHARTLTTLREDLVLEKL 919
+ A EKE++AL LAR + A + K E E+ N+ L + EDL+ K
Sbjct: 1475 EAEAREKETKAL--SLARALEEALEAKEEFERQNKQLRADM-----------EDLMSSKD 1521
Query: 920 KSQQLSSELDK----LSQELEKVGLNRELLLQEDDSGSDTKYKI------LEGRNESALK 969
+ EL+K L Q++E++ E L E + D K ++ ++ + E L+
Sbjct: 1522 DVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQ 1581
Query: 970 TTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAG 1029
T EEK LL Q+ R+LE+EL+ +K+ ++ + ++ K
Sbjct: 1582 TRDEQNEEKKRLLIKQV-------RELEAELEDERKQRALAVASK---KKMEIDLKDLEA 1631
Query: 1030 KTAASHQGKEAWGPGHKEATMELLRVKDRAIELERNNAALQAEKQLLKEQLQHLETQNVT 1089
+ A+++ ++ E +L +++ + + +R +A + + Q + E + +
Sbjct: 1632 QIEAANKARD-------EVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKS 1684
Query: 1090 FSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETE 1149
++IL LQ++ A + + + +L E + +S +AL + L+ E E
Sbjct: 1685 LEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEE 1744
Query: 1150 NESLQRQQEQLTAAY-EALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHR-NLELEHK 1207
E Q E L + + LQ + TL+ +AE A + + + L R N EL+ K
Sbjct: 1745 LEEEQSNMELLNDRFRKTTLQ----VDTLNAELAAERSAAQKSDNARQQLERQNKELKAK 1800
Query: 1208 ELGERHGDM-LKRKAELEEREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLH- 1265
L E G + K KA + E + E L+QE + A A +R +L + F+
Sbjct: 1801 -LQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEI-FMQV 1858
Query: 1266 -------HQLKGEYEELHAHTKELKTSLNNAQLELNR-------WQARFDELKEQHQTMD 1311
Q K + E+ +A K+LK L A+ E R Q D+ E ++ +
Sbjct: 1859 EDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLS 1918
Query: 1312 ISLTKLDN 1319
++ L N
Sbjct: 1919 REVSTLKN 1926
Score = 160 bits (406), Expect = 9e-39
Identities = 259/1122 (23%), Positives = 480/1122 (42%), Gaps = 162/1122 (14%)
Query: 122 KVLLLVLGCAVQCERKEEFIERIKQLDIETQAGIVAHIQEVTHNQENVFDLQWLELPDVA 181
K LL V + + K+E + ++K E Q + ++E+ + Q LE ++
Sbjct: 842 KPLLQVTRQEEELQAKDEELLKVK----EKQTKVEGELEEMERKHQ-----QLLEEKNIL 892
Query: 182 PEELEALSR--SMVLHLR-RLIDQRDECTELIVDLT------QERDYLQAQHPPSPIKSS 232
E+L+A + + +R RL ++ E E++ DL +ER+ + Q+ +++
Sbjct: 893 AEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQI-LQNEKKKMQAH 951
Query: 233 SADSTPSPTSSLSSED--KQHLAVELADTKARLRRVRQE---LEDKTEQLVDTRHEVDQL 287
D L E+ +Q L +E +A+++++ +E LED+ + + + ++
Sbjct: 952 IQDLE----EQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDR 1007
Query: 288 VLELQKVKQENIQLAADARSARAYRDELDS-LREKANRVERLELELTRCKEKLH-DVDFY 345
+ E E + A + R ++ + S L E+ + E+ EL + K KL +
Sbjct: 1008 IAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDL 1067
Query: 346 KARMEELREDNIILIETKAMLEEQLTAARARGDK-----------VHELEKENLQLKSKL 394
+ ++ EL+ L A EE+L A ARGD V EL+ + +L+
Sbjct: 1068 QDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDF 1127
Query: 395 HDLELDRDTDKKRIEELLEENMVLEIAQKQSMN--------------ESAHLGWELEQLS 440
+ R+ +K+ +L EE L+ + +++ E A L LE+ +
Sbjct: 1128 ESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEET 1187
Query: 441 KN--ADLSD-----ASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASLVLE--- 490
KN A + D A+ + E E A LEK Q L++ + L VL+
Sbjct: 1188 KNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVK 1247
Query: 491 ---------------ESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELI 535
E K E ++ +L++K KLQ +L+ ++ E +
Sbjct: 1248 AESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFA 1307
Query: 536 REKEQLQS---DMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKEN 592
++ L+S D + L ++ RQ +L L SL+E+ + EAR K++EK+
Sbjct: 1308 KDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEAR-KNLEKQV 1366
Query: 593 KALHQTVTEAN-------GKLSQLEFEKRQLHRDLE----QAKEKGERAEKLERELQRLQ 641
AL + + G + LE K++L +D E + +EK +KLE+ RLQ
Sbjct: 1367 LALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQ 1426
Query: 642 EENGRLA------RKVTS-LETATEKVEALEHESQGLQL--------------ENRTLRK 680
+E L R+V S LE +K + L E + + E T
Sbjct: 1427 QELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKAL 1486
Query: 681 SLDTLQNVSLQL-EGLERDNKQLDAENLELRRLVETMRFTSTKLAQMERENQQLEREKEE 739
SL +L+ E ER NKQL A+ + L+ + + ++E+ + LE++ EE
Sbjct: 1487 SLARALEEALEAKEEFERQNKQLRAD---MEDLMSSKDDVGKNVHELEKSKRALEQQVEE 1543
Query: 740 LRKNV----DLLKALGKKSERLELSYQSVSAENLR-LQQSLESSSHKTQTLESELGELEA 794
+R + D L+A RLE++ Q++ A+ R LQ E + K + L ++ ELEA
Sbjct: 1544 MRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEA 1603
Query: 795 ERQALRRDLEALRLAN------------AQLEGAEKDRKALEQEVAQLEKDKKLLEKEAK 842
E + R+ AL +A+ AQ+E A K R + +++ +L+ K ++E +
Sbjct: 1604 ELEDERKQ-RALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELE 1662
Query: 843 RLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDNRDLTKQVTV 902
+ A +S KL ++E E L +ELA A + E++ +L ++T
Sbjct: 1663 EARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERAR---RHAEQERDELADEITN 1719
Query: 903 HARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSDTKYKILEG 962
A + L ++ ++L + + +L +ELE+ N ELL +D T ++
Sbjct: 1720 SASGKSALLDE-------KRRLEARIAQLEEELEEEQSNMELL---NDRFRKTTLQVDTL 1769
Query: 963 RNESALKTTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLK-----KECETLRQNQGEG 1017
E A + + A K + Q+E + N++L+++LQ L+ K T+ + +
Sbjct: 1770 NAELAAERSAAQKSDNA---RQQLERQ---NKELKAKLQELEGAVKSKFKATISALEAKI 1823
Query: 1018 QHLQNSFKHPAGKTAASHQGKEAWGPGHKEATMELLRVKDRAIELERNNAALQAEKQLLK 1077
L+ + A + AA+++ KE M++ + A + + A + LK
Sbjct: 1824 GQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLK 1883
Query: 1078 EQLQHLETQNVTFSSQILTLQKQSAFLQEHNTTLQTQTAKLQ 1119
QL+ E + ++ LQ++ E N L + + L+
Sbjct: 1884 RQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLK 1925
Score = 153 bits (386), Expect = 2e-36
Identities = 209/903 (23%), Positives = 388/903 (42%), Gaps = 149/903 (16%)
Query: 212 DLTQERDYLQAQHPPSPIKSSSADSTPSPTSSLSSEDKQHLAVELADTKARLRRVRQE-- 269
DL++E + L+ + + +++ + +E K+ L E + +A+++ +RQ
Sbjct: 1143 DLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHA 1202
Query: 270 --LEDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSARAYRDE-----------LD 316
LE+ +EQL + L Q ++ +N +LA + + + + E +
Sbjct: 1203 TALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQ 1262
Query: 317 SLREKANRVERLELELTRCKEKL-HDVDFYKARMEELREDNIILIETKAMLEEQLTAARA 375
L K + +RL +EL KL +++D +EE + I + A LE QL +
Sbjct: 1263 ELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQ- 1321
Query: 376 RGDKVHELEKENLQLKSKLHDLELDRDTDKKRIEELLEENMVLEIAQKQSMNESAHLGWE 435
+ + E ++ L L S++ LE ++++ + ++Q E A E
Sbjct: 1322 --ELLQEETRQKLNLSSRIRQLEEEKNS----------------LQEQQEEEEEARKNLE 1363
Query: 436 LEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASLVLEESGLK 495
+ L+ + L+D +K + +E ++ + ++ S LEE L
Sbjct: 1364 KQVLALQSQLADTKKK---------VDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALA 1414
Query: 496 CGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSDMETLKADKARQ 555
+LEK ++L ++++ L L+ ++Q +LE ++ +QL ++ +++ A A
Sbjct: 1415 YDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKF----DQLLAEEKSISARYA-- 1468
Query: 556 IKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALH--QTVTEANGKLSQLEFEK 613
ER + +EAR EKE KAL + + EA + E +
Sbjct: 1469 ------------------EERDRAEAEAR----EKETKALSLARALEEALEAKEEFERQN 1506
Query: 614 RQLHRDLEQAKEKGERAEKLERELQRLQEENGRLARKVTSLETATEKVEALEHESQGLQL 673
+QL D+E + K EL++ + L ++V + T ++E LE E Q
Sbjct: 1507 KQLRADMEDLMSSKDDVGKNVHELEKSKR---ALEQQVEEMRT---QLEELEDELQA--T 1558
Query: 674 ENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVETMRFTSTKLAQMERENQQL 733
E+ LR + N+ ERD + D +N E +RL + ++ ++L
Sbjct: 1559 EDAKLRLEV----NMQAMKAQFERDLQTRDEQNEEKKRL-------------LIKQVREL 1601
Query: 734 EREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSSHKTQTLESELGELE 793
E E E+ RK L A KK +E+ + + A+ +E+++ + +L +L+
Sbjct: 1602 EAELEDERKQRALAVASKKK---MEIDLKDLEAQ-------IEAANKARDEVIKQLRKLQ 1651
Query: 794 AERQALRRDLEALRLAN----AQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQQ-V 848
A+ + +R+LE R + AQ + +EK K+LE E+ QL+++ E+ + Q+
Sbjct: 1652 AQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERD 1711
Query: 849 ELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDNRDLTKQVTVHARTLT 908
EL D + + ++ K SA+ E R L+ +A+ + +L+E + + L + +
Sbjct: 1712 ELADEITNSASGK-SALLDEKRRLEARIAQLEE---ELEEEQSNMELLNDRFRKTTLQVD 1767
Query: 909 TLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSDTKYKILEGRNESAL 968
TL +L E+ +Q + D Q+LE+ + LQE LEG +S
Sbjct: 1768 TLNAELAAERSAAQ----KSDNARQQLERQNKELKAKLQE-----------LEGAVKSKF 1812
Query: 969 KTTLAMKEEKIVLLEAQME----EKASLNRQLESELQMLKKECETLRQNQGEGQHLQNSF 1024
K T++ E KI LE Q+E E+A+ N+ + + LK E Q + E +H
Sbjct: 1813 KATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLK---EIFMQVEDERRHADQYK 1869
Query: 1025 KHPAGKTAASHQGKEAWGPGHKEAT------MELLRVKDRAIELERNNAALQAEKQLLKE 1078
+ A Q K +EAT +L R D A E N L E LK
Sbjct: 1870 EQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEA---NEGLSREVSTLKN 1926
Query: 1079 QLQ 1081
+L+
Sbjct: 1927 RLR 1929
Score = 152 bits (384), Expect = 3e-36
Identities = 239/1064 (22%), Positives = 435/1064 (40%), Gaps = 125/1064 (11%)
Query: 459 ECASSRILKLEKENQSLQSTIQGL-RDASLVLEESGLKCGELEKENHQLSKKIEKLQTQL 517
+ +LK++++ ++ ++ + R +LEE + +L+ E +L + E+++ +L
Sbjct: 855 QAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAET-ELFAEAEEMRARL 913
Query: 518 EREKQSNQDLETLSEELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERS 577
+KQ +++ E + E+E+ ++ K I+DLE++ D A L +
Sbjct: 914 AAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKL-QLE 972
Query: 578 QVSSEARMKDVE--------------KENKALHQTVTEANGKLSQLEFEKRQLHRDLEQA 623
+V++EA++K +E KE K + + E + +L++ E E+A
Sbjct: 973 KVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEE----------EKA 1022
Query: 624 KEKGERAEKLERELQRLQEENGRLARKVTSLETATEKVEALEHESQGLQLENRTLRKSLD 683
K + K E + L+E + + LE A K L+ E+ LQ + L+ +D
Sbjct: 1023 KNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRK---LDGETTDLQDQIAELQAQID 1079
Query: 684 TLQ-NVSLQLEGLERDNKQLDAENLELRRLVETMRFTSTKLAQMER--ENQQLEREKEEL 740
L+ ++ + E L+ + D E L ++ +R ++A+++ E+++ R K E
Sbjct: 1080 ELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEK 1139
Query: 741 RKNVDLLKALGKKSERLELSYQSVSA-ENLRLQQSLESSSHKTQTLESELGELEAERQAL 799
+K DL + L LE + + +A + LR ++ E + K + LE E EA+ Q +
Sbjct: 1140 QKR-DLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELK-KALEEETKNHEAQIQDM 1197
Query: 800 R-RDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQ---QVELKDAVL 855
R R AL + QLE A++ + LE+ LE D K L E K L Q + E K L
Sbjct: 1198 RQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKL 1257
Query: 856 DDSTAKLSAVEKESRALDKELAR--------------------------CRDAAGKLKEL 889
D +L A E L ELA +DAA +L
Sbjct: 1258 DAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQL 1317
Query: 890 EKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQED 949
+ D ++L ++ T L++ L EK Q+ E ++ + LEK L + L
Sbjct: 1318 Q-DTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQL--- 1373
Query: 950 DSGSDTKYKI---------LEGRNESALKTTLAMK---EEKIVLLEAQMEEKASLNRQLE 997
+DTK K+ LE + LK A+ EEK + + + K L ++L+
Sbjct: 1374 ---ADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELD 1430
Query: 998 S---ELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEATMELLR 1054
+L ++ L + Q + L K + + A EA + + L R
Sbjct: 1431 DLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLAR 1490
Query: 1055 VKDRAI----ELERNNAALQAE-------KQLLKEQLQHLETQNVTFSSQILTLQKQSAF 1103
+ A+ E ER N L+A+ K + + + LE Q+ ++ Q
Sbjct: 1491 ALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQ--- 1547
Query: 1104 LQEHNTTLQ-TQTAKLQVE----------NSTLSSQSAALTAQYTLLQNHHTAKETENES 1152
L+E LQ T+ AKL++E L ++ + LL E E E
Sbjct: 1548 LEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELED 1607
Query: 1153 LQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGER 1212
++Q+ A+ + + D + L E + + +I+Q L+ ++ + E +E
Sbjct: 1608 ERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARAS 1667
Query: 1213 HGDMLKRKAELEEREKVLTTEREALQQE----QRTNALAMGENQRLRGELDRVNFLHHQL 1268
++ + E E++ K L E LQ+E +R A E L E+ L
Sbjct: 1668 RDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSAL 1727
Query: 1269 KGEYEELHAHTKELKTSLNNAQLELNRWQARFDELKEQHQTMDISLTKLDNHCELLSRLK 1328
E L A +L+ L Q + RF + Q T++ L + + +
Sbjct: 1728 LDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNAR 1787
Query: 1329 GNLEEENHHLLSQIQLLSQQNQMLLEQNM--------ENKEQYHEEQKQYIDKLNALRRH 1380
LE +N L +++Q L + + + + +EQ +E K+ +RR
Sbjct: 1788 QQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRT 1847
Query: 1381 KEKLEEKIMDQYKFYDPPPKKKNHWIGAKALVKLIKPKKEGSRE 1424
++KL+E M + K A A +K +K + E + E
Sbjct: 1848 EKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEE 1891
Score = 123 bits (309), Expect = 2e-27
Identities = 162/712 (22%), Positives = 319/712 (44%), Gaps = 61/712 (8%)
Query: 212 DLTQERDYLQAQHPPSPIKSSSADSTPSPTSSLSSEDKQHLAVELADTKARLRR------ 265
+L E LQ S K D+ + SE + L VELA+ ++L+
Sbjct: 1235 ELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDR-LRVELAEKASKLQNELDNVS 1293
Query: 266 -VRQELEDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSA-RAYRDELDSLREKAN 323
+ +E E K + ++ + + Q++ QE + + S R +E +SL+E+
Sbjct: 1294 TLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQE 1353
Query: 324 RVER----LELELTRCKEKLHD----VDFYKARMEELREDNIILIETKAMLEEQLTAARA 375
E LE ++ + +L D VD +E L E L++ L ++L
Sbjct: 1354 EEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKAL 1413
Query: 376 RGDKVHELEKENLQLKSKLHDLELDRDTDKKRIEELLEENMVLEIAQKQSMNESAHLGWE 435
DK LEK +L+ +L DL +D D ++ L ++ + + + SA E
Sbjct: 1414 AYDK---LEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEE 1470
Query: 436 LEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASLVLEESGLK 495
++ A + S L E ++ + E++N+ L++ ++ L + ++ G
Sbjct: 1471 RDRAEAEAREKETKALSLARALEEALEAKE-EFERQNKQLRADMEDLMSSK---DDVGKN 1526
Query: 496 CGELEKENHQLSKKIEKLQTQLER---EKQSNQDLET-LSEELIREKEQLQSDMETLKAD 551
ELEK L +++E+++TQLE E Q+ +D + L + K Q + D++T
Sbjct: 1527 VHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQ 1586
Query: 552 KA-------RQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEANG 604
+Q+++LE E + R +L S+ E +KD+E + +A ++ E
Sbjct: 1587 NEEKKRLLIKQVRELEAELED-ERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIK 1645
Query: 605 KLSQLEFEKRQLHRDLEQAKEKGE----RAEKLERELQRLQEENGRLARKVTSLETATEK 660
+L +L+ + + R+LE+A+ + ++++ E++L+ L+ E +L ++ S E A
Sbjct: 1646 QLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRH 1705
Query: 661 VEALEHESQGLQLENRTLRKS--LDTLQNVSLQLEGLERDNKQLDAENLELRRLVETMRF 718
E E + ++ N KS LD + + ++ LE + ++ + N+EL RF
Sbjct: 1706 AEQ-ERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEE-EQSNMELLN----DRF 1759
Query: 719 TSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVS-AENLRLQQSLES 777
T L Q++ N +L E+ +K+ + + L ++++ L+ Q + A + + ++ +
Sbjct: 1760 RKTTL-QVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISA 1818
Query: 778 SSHKT----QTLESELGELEAERQALRRDLEALRLANAQLEG----AEKDRKALEQEVAQ 829
K + LE E E A + +RR + L+ Q+E A++ ++ +E+ A+
Sbjct: 1819 LEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANAR 1878
Query: 830 LEKDKKLL---EKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELAR 878
+++ K+ L E+EA R LDD+T + +E L L R
Sbjct: 1879 MKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRR 1930
Score = 122 bits (306), Expect = 4e-27
Identities = 166/737 (22%), Positives = 307/737 (41%), Gaps = 93/737 (12%)
Query: 697 RDNKQLDAENLELRRLVETMRFTSTKLAQMERENQQLEREK----EELRKNVDLLKALGK 752
R ++L A++ EL ++ E +L +MER++QQL EK E+L+ +L +
Sbjct: 849 RQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEE 908
Query: 753 KSERLELSYQSVSAENLRLQQSLESSSHKTQTLESELGELEAERQALRRDLEALRLANAQ 812
RL Q + L+ +E + Q L++E +++A Q L L+ A +
Sbjct: 909 MRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQK 968
Query: 813 LEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRAL 872
L + ++ E ++ ++E++ LLE + + ++ +L + + + +++L+ E++++ L
Sbjct: 969 L---QLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNL 1025
Query: 873 ----DKELARCRDAAGKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSEL 928
+K+ D +LK+ EK ++L K T L++ + + + +L +L
Sbjct: 1026 AKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQL 1085
Query: 929 DKLSQELEKVGLNRELLLQEDDSGSDTKYKILEGRNESALKTTLAMKEEKIVLLEAQMEE 988
K +EL+ L + DD +T +K +ALK ++ + L E E
Sbjct: 1086 AKKEEELQGA------LARGDD---ETLHK------NNALKVVRELQAQIAELQEDFESE 1130
Query: 989 KASLN------RQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAG--KTAASHQGKEA 1040
KAS N R L EL+ LK E E Q L+ + K A + K
Sbjct: 1131 KASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETK-- 1188
Query: 1041 WGPGHKEATMELLRVKDRAIELERNNAALQAEKQL---LKEQLQHLETQNVTFSSQILTL 1097
+ EA ++ +R + A LE + L+ K+ L++ Q LET N + ++ L
Sbjct: 1189 ----NHEAQIQDMRQR-HATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVL 1243
Query: 1098 QKQSAFLQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETENESLQRQQ 1157
Q+ A + L Q +L + S L + + LQN T E +++
Sbjct: 1244 QQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKG 1303
Query: 1158 EQL---TAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKT-----------LHRNLE 1203
+ A+ E+ LQD + L RQ + IRQ K +NLE
Sbjct: 1304 IKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLE 1363
Query: 1204 LEHKELGERHGDMLKRKAE-------LEEREKVLTTEREALQQEQRTNALAMGENQRLRG 1256
+ L + D K+ + LEE +K L + EAL Q ALA
Sbjct: 1364 KQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALA--------- 1414
Query: 1257 ELDRVNFLHHQLKGEYEELHAHTKELKTSLNNAQLELNRWQARFDELKEQHQTMDISLTK 1316
D++ ++L+ E ++L + +N L + Q +FD+L + +++
Sbjct: 1415 -YDKLEKTKNRLQQELDDLTVDLDHQRQVASN----LEKKQKKFDQLLAEEKSISA---- 1465
Query: 1317 LDNHCELLSRLKGNLEEENHHLLSQIQLLSQQNQMLLEQNMENKEQYHEEQKQYIDKLNA 1376
+ E R + E+ LS + LE+ +E KE++ + KQ +
Sbjct: 1466 --RYAEERDRAEAEAREKETKALSLAR--------ALEEALEAKEEFERQNKQLRADMED 1515
Query: 1377 LRRHKEKLEEKIMDQYK 1393
L K+ + + + + K
Sbjct: 1516 LMSSKDDVGKNVHELEK 1532
Score = 105 bits (262), Expect = 4e-22
Identities = 147/678 (21%), Positives = 290/678 (42%), Gaps = 108/678 (15%)
Query: 247 EDKQHLAVELADTKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADAR 306
E+K L + + + + + +++ QL DT+ +VD + ++ +++ +L DA
Sbjct: 1343 EEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAE 1402
Query: 307 SARAYRDELDSLREKANRVERLELELTRCKEKLHDVDFYKARMEELREDNIILIETKAML 366
+ L EKA ++LE R +++L D+ ++ + +E K
Sbjct: 1403 ALS------QRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASN----LEKKQKK 1452
Query: 367 EEQLTAARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIEELLEENMVLEIAQKQSM 426
+QL A + E++ + +++ + E + + +EE LE E KQ
Sbjct: 1453 FDQLLAEEKSISARYAEERDRAEAEAR--EKETKALSLARALEEALEAKEEFERQNKQLR 1510
Query: 427 NESAHLGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDAS 486
+ L + + KN + S+++ ++ E + + + L+ +Q DA
Sbjct: 1511 ADMEDLMSSKDDVGKNVHELEKSKRALEQQVEE--------MRTQLEELEDELQATEDAK 1562
Query: 487 LVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQS-NQDLETLSEELIREKEQLQSDM 545
L LE + ++ ++ Q ER+ Q+ ++ E LI++ +L++++
Sbjct: 1563 LRLEVN-----------------MQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAEL 1605
Query: 546 ETLKADKAR----------QIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKE---- 591
E + +A +KDLE + + N+A + ++ + +A+MKD ++E
Sbjct: 1606 EDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLR-KLQAQMKDYQRELEEA 1664
Query: 592 ---NKALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLEREL----------- 637
+ E+ KL LE E QL +L ++ AE+ EL
Sbjct: 1665 RASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGK 1724
Query: 638 QRLQEENGRLARKVTSLETATEKVEALEHESQGLQLENRTLRKS---LDTLQNVSLQLE- 693
L +E RL ++ LE E LE E ++L N RK+ +DTL N L E
Sbjct: 1725 SALLDEKRRLEARIAQLE------EELEEEQSNMELLNDRFRKTTLQVDTL-NAELAAER 1777
Query: 694 -----------GLERDNKQLDAENLELRRLVE-----TMRFTSTKLAQMERENQQLEREK 737
LER NK+L A+ EL V+ T+ K+ Q+E +QLE+E
Sbjct: 1778 SAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLE---EQLEQEA 1834
Query: 738 EELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSSHKTQTLESELGELEAERQ 797
+E L++ KK + + + + + ++ +E ++ + + L+ +L EAE +
Sbjct: 1835 KERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLE--EAEEE 1892
Query: 798 ALRRDLEALRLANAQLEGAEKDRKALEQEVA----QLEKDKKLLEKEAKRLWQQVELKDA 853
A R + +L +L+ A + + L +EV+ +L + + ++ +Q+ L+ A
Sbjct: 1893 ATRANASRRKL-QRELDDATEANEGLSREVSTLKNRLRRGGPISFSSSRSGRRQLHLEGA 1951
Query: 854 VL----DDSTAKLSAVEK 867
L DD+ +K S V +
Sbjct: 1952 SLELSDDDTESKTSDVNE 1969
Score = 92.4 bits (228), Expect = 4e-18
Identities = 150/643 (23%), Positives = 276/643 (42%), Gaps = 90/643 (13%)
Query: 135 ERKEEFIERIKQLDIETQAGIVAHIQEVTHNQENVFDLQWLELPDVAPEEL----EALSR 190
E++EE E K L+ + A + + + + ++ DL +E + A ++L EALS+
Sbjct: 1350 EQQEEEEEARKNLEKQVLA-LQSQLADTKKKVDD--DLGTIESLEEAKKKLLKDAEALSQ 1406
Query: 191 SM---VLHLRRLIDQRDECTELIVDLTQERDYLQAQHPPSPIKSSSADSTPSPTSSLSSE 247
+ L +L ++ + + DLT + D+ + K D + S+S+
Sbjct: 1407 RLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISAR 1466
Query: 248 -------------DKQHLAVELA-------DTKARLRRVRQELEDKTEQLVDTRHEVDQL 287
+K+ A+ LA + K R ++L E L+ ++ +V +
Sbjct: 1467 YAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKN 1526
Query: 288 VLELQKVKQENIQLAADARSA-RAYRDELDSLREKANRVE--------RLELELTRCKEK 338
V EL+K K+ Q + R+ DEL + + R+E + E +L E+
Sbjct: 1527 VHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQ 1586
Query: 339 --------LHDVDFYKARMEELREDNIILIETKAM-------LEEQLTAA-RARGDKVHE 382
+ V +A +E+ R+ + + +K LE Q+ AA +AR + + +
Sbjct: 1587 NEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQ 1646
Query: 383 LEKENLQLKSKLHDLELDRDT----------DKKRIEELLEENMVLEIAQKQSMNESAHL 432
L K Q+K +LE R + +K+++ L E + L+ S H
Sbjct: 1647 LRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHA 1706
Query: 433 GWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASLVLEES 492
E ++L+ S AS KS + + +RI +LE+E + QS ++ L D ++
Sbjct: 1707 EQERDELADEITNS-ASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDR---FRKT 1762
Query: 493 GLKCGELEKE---NHQLSKKIEKLQTQLEREKQSNQDLETLSEELIRE-KEQLQSDMETL 548
L+ L E ++K + + QLER+ N++L+ +EL K + ++ + L
Sbjct: 1763 TLQVDTLNAELAAERSAAQKSDNARQQLERQ---NKELKAKLQELEGAVKSKFKATISAL 1819
Query: 549 KADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQ---TVTEANGK 605
+A + + LEQE A +R + E M+ VE E + Q + +AN +
Sbjct: 1820 EAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQ-VEDERRHADQYKEQMEKANAR 1878
Query: 606 LSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGRLARKVTSLETATEKVEALE 665
+ QL KRQL E+A KL+REL E N L+R+V++L+ + +
Sbjct: 1879 MKQL---KRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGPIS 1935
Query: 666 HESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLE 708
S +R+ R+ L L+ SL+L + ++K D +
Sbjct: 1936 FSS------SRSGRRQLH-LEGASLELSDDDTESKTSDVNETQ 1971
Score = 72.8 bits (177), Expect = 3e-12
Identities = 117/559 (20%), Positives = 227/559 (40%), Gaps = 77/559 (13%)
Query: 109 RDPLSGKSMEEIKKVLLLVLGCAVQCERKEEFIERIKQLDIETQAGIVAHIQEVTHNQEN 168
RD ++ E+ K L L E KEEF + KQL + + +++ +V +N
Sbjct: 1471 RDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADME-DLMSSKDDV---GKN 1526
Query: 169 VFDLQWLELPDVAPEELEALSRSMVLHLRRLIDQRDECTELIVDLTQERDYLQAQHPPSP 228
V +L + + LE M L L D+ + + L ++AQ
Sbjct: 1527 VHEL------EKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERD- 1579
Query: 229 IKSSSADSTPSPTSSLSSEDKQHLAVELADTK-------ARLRRVRQELEDKTEQLVDTR 281
+ D L + + L EL D + A +++ +L+D Q+
Sbjct: 1580 --LQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAAN 1637
Query: 282 HEVDQLVLELQKVKQENIQLAADARSARAYRDEL-DSLREKANRVERLELELTRCKEKLH 340
D+++ +L+K++ + + ARA RDE+ +E +++ LE E+ + +E+L
Sbjct: 1638 KARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELA 1697
Query: 341 DVDFYKARMEELREDNIILIETKAMLEEQLTAARARGDKVHELEKENLQLKSKLHDLELD 400
+ + E+ R++ L +++T + A G L E +L++++ LE +
Sbjct: 1698 SSERARRHAEQERDE----------LADEITNS-ASGKSA--LLDEKRRLEARIAQLEEE 1744
Query: 401 RDTDKKRIEELLEENMVLEIAQKQSMNESAHLGWELEQLSKNADLSDASRKSFVFELNEC 460
+ ++ + ELL + Q ++N EL A SD +R+
Sbjct: 1745 LEEEQSNM-ELLNDRFRKTTLQVDTLNA------ELAAERSAAQKSDNARQ--------- 1788
Query: 461 ASSRILKLEKENQSLQSTIQGLRDA-----SLVLEESGLKCGELEKENHQLSKKIEKLQT 515
+LE++N+ L++ +Q L A + K G+LE++ Q +K+
Sbjct: 1789 ------QLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANK 1842
Query: 516 QLEREKQSNQDLETLSEELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRE 575
+ R ++ +++ E+ R +Q + ME A + + LE+ ++ RA S R+
Sbjct: 1843 LVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRK 1902
Query: 576 RSQVSSEARMKDVEKENKALHQTVTEANGKL--------SQLEFEKRQLHRD---LEQAK 624
+ + D + N+ L + V+ +L S +RQLH + LE +
Sbjct: 1903 -----LQRELDDATEANEGLSREVSTLKNRLRRGGPISFSSSRSGRRQLHLEGASLELSD 1957
Query: 625 EKGERAEKLERELQRLQEE 643
+ E E Q Q E
Sbjct: 1958 DDTESKTSDVNETQPPQSE 1976
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 170 bits (430), Expect = 1e-41
Identities = 264/1210 (21%), Positives = 517/1210 (42%), Gaps = 165/1210 (13%)
Query: 196 LRRLIDQRDECTELIVDLTQERDYLQAQHPPSPIKSSSADSTPSPTS----SLSSEDKQH 251
LR ++D E + L E + L +Q P ++ + SLS D
Sbjct: 523 LRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTM- 581
Query: 252 LAVELADTKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSARAY 311
L + + ++ + +E +D +L ++ E+D + ++ ++ ++L Y
Sbjct: 582 ----LKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQY 637
Query: 312 RDELD------------SLREKANRVERLELELTRCKEKLHDVDFYKARMEELREDNIIL 359
EL+ +L+EK ++LE + + K D + A ++ L E+N L
Sbjct: 638 NSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKL 697
Query: 360 IETKAMLEEQLTAARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIEELLEE----N 415
K L L +V +KE++ LK + LE K+++ ++EE N
Sbjct: 698 SSEKKQLSRDL--------EVFLSQKEDVILKEHITQLE-------KKLQLMVEEQDNLN 742
Query: 416 MVLEIAQKQSMNESAHLGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSL 475
+LE Q Q + L L+++ +++S+ S + V + + + K+ +E +L
Sbjct: 743 KLLENEQVQKLFVKTQLYGFLKEMG--SEVSEDSEEKDVVNVLQAVGESLAKINEEKCNL 800
Query: 476 QSTIQGLRDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELI 535
RD ++ E +KC L++E+ ++++ L E+EK L EE+
Sbjct: 801 AFQ----RDEKVLELEKEIKC--LQEESVVQCEELKSLLRDYEQEKVL---LRKELEEIQ 851
Query: 536 REKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVE-----K 590
EKE LQSD+ +K A + LE + + + E SQ S++ + + + K
Sbjct: 852 SEKEALQSDLLEMK--NANEKTRLENQN-----LLIQVEEVSQTCSKSEIHNEKEKCFIK 904
Query: 591 ENKALHQTVT--EANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGRLA 648
E++ L + E + ++L K L + + ++LE +++ L++E
Sbjct: 905 EHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKE 964
Query: 649 RKVTSLETATEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLE 708
K+ ++ K + + L S Q V +LE L + QL A
Sbjct: 965 EKINKIKLVAVKAK-------------KELDSSRKETQTVKEELESLRSEKDQLSAS--- 1008
Query: 709 LRRLVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAEN 768
+R L++ L + E++++QL+ EKE ++ L ++ L ++++++N
Sbjct: 1009 MRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDN 1068
Query: 769 LRLQQSLESSSHKTQTLESELGELEAERQALRRDLEALRLANAQ-LEGAEKDRKALEQEV 827
L +E+ + LE ++ E++ + + ++LEA +L Q ++ LE+
Sbjct: 1069 EDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQ 1128
Query: 828 AQLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLK 887
QL+K+KK L+K + L ++ KDA T ++ + L KEL + KL
Sbjct: 1129 VQLQKEKKQLQKTMQEL--ELVKKDA---QQTTLMNMEIADYERLMKELNQ------KLT 1177
Query: 888 ELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQ 947
DL +++ + + TL+E++ + QQ + K+ Q L K +EL
Sbjct: 1178 NKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKT--KKEL--- 1232
Query: 948 EDDSGSDTKYKILEGRNESALKTTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLKKEC 1007
D ++T + IL +++LK L ++++ + + Q+ E S ++ L+ ++
Sbjct: 1233 ADSKQAETDHLIL----QASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQH 1288
Query: 1008 E-TLRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEATMELLRVKDRAIELERNN 1066
+ TL Q LQ + + A E++ +RV + ++ ++N
Sbjct: 1289 QRTLSAYQQRVTALQEECRAAKAEQATVTSEFESY----------KVRVHN-VLKQQKNK 1337
Query: 1067 AALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLS 1126
+ QAE + K++ +HLE + + + LQ+ LQ ++LQ TL
Sbjct: 1338 SMSQAETEGAKQEREHLE----------MLIDQLKIKLQDSQNNLQINVSELQ----TLQ 1383
Query: 1127 SQSAALTAQYTLLQNHH-TAKETENESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEY 1185
S+ TLL+ H+ +ET ++ + +++ + E ++ EH T+ + S +
Sbjct: 1384 SE------HDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTS-QN 1436
Query: 1186 EALIRQHSCLKTLHRNLELEHKELGERHGDML-KRKAELEEREKVLTTEREALQQEQRTN 1244
E L + + R+L+ EH++ E L K +A+L + + TT Q+ N
Sbjct: 1437 EVL---RNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKN 1493
Query: 1245 ALAMGENQRLRGELDRVNFLHHQLKGEYEELH-----------AHTKELKTSLNN--AQL 1291
+R +L ++ +H + E E + +T+ L+ LN+ +L
Sbjct: 1494 L-----RERRNTDLPLLD-MHTVTREEGEGMETTDTESVSSASTYTQSLEQLLNSPETKL 1547
Query: 1292 ELNRWQARFDELKEQHQTMDISLTKLDNHCELLSRLKGNLEEENHHLLSQIQLLSQQNQM 1351
E W A F KE+ S TK +H L+ L E N L+ QI+LL + +
Sbjct: 1548 EPPLWHAEF--TKEELVQKLSSTTKSADH---LNGLLRETEATNAILMEQIKLLKSEIRR 1602
Query: 1352 LLEQNMENKE 1361
LE+N E ++
Sbjct: 1603 -LERNQEREK 1611
Score = 157 bits (398), Expect = 8e-38
Identities = 296/1401 (21%), Positives = 551/1401 (39%), Gaps = 258/1401 (18%)
Query: 178 PDVAPEELEALSRSMVLHLRR----LIDQ-RDECTELIVDLTQERDYLQAQHPPSPIKSS 232
P +LE L + ++ + LI + + CTEL ++ + R P+
Sbjct: 15 PGTGKSKLETLPKEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRS--------KPVTEG 66
Query: 233 SADSTPSPTSSLSSE--DKQHLAVELADTKARLRRVRQELEDKTEQLVDTRHEVDQ---- 286
+ D + T L + +K + K +++QE+ED ++ D E++Q
Sbjct: 67 TGDIIKALTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHIN 126
Query: 287 LVLELQKVKQENIQLAADARSARAYRDELDSLREKANRVERLELELTRCKEKLHDVDFYK 346
V E++ +K E + + + Y ++ +L+++ +LEL+ E+L + +
Sbjct: 127 YVKEIENLKNELMAVRSK------YSEDKANLQKQLEEAMNTQLELS---EQLKFQNNSE 177
Query: 347 ARMEELREDNIILIETKAMLEEQLTAARARGDKVHELEKENLQLKSKLHDLELDRDTDKK 406
+++L+E+ + + + EEQ+ + + D + +KE + + +E + +K
Sbjct: 178 DNVKKLQEE---IEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNI--IEANSQHYQK 232
Query: 407 RIEELLEENMVLEIAQKQSMNESAHLGWELEQLSKNADLSDASRKSFVFELNECASSRIL 466
I L EE + L+ ++ E+++L + S ++ + +LNE + +
Sbjct: 233 NINSLQEELLQLKAIHQE----------EVKELMCQIEASAKEHEAEINKLNELKENLVK 282
Query: 467 KLEKENQSLQST----IQGLRDASLVLEESGLKCGELEKEN------------------- 503
+ E +++Q ++ LR A+ + C L +EN
Sbjct: 283 QCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLK 342
Query: 504 -----HQLSKK----IEKLQTQLEREKQ--------SNQDLETLSEELIREKEQLQSDME 546
H + K + L+ +LE + Q +DLE EL+ KE+ +E
Sbjct: 343 ELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIE 402
Query: 547 TLKADKARQIKDLEQEKDHLNRAMWSLRERSQVS----SEARMKDVEKENKALHQTVTEA 602
LK++ A K + NR + SL+E+ Q +E + D EKE L +
Sbjct: 403 KLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQGL 462
Query: 603 NGKLSQLEFEKRQLHRDLEQAK--------EKGERAEKLERELQRLQE------------ 642
+ L+ EK++ + E + E GE A K+ +E + +++
Sbjct: 463 KEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQK 522
Query: 643 ------ENGRLARKVTSLETATEK-------VEALEHESQGLQLENRTLRKSLDTLQNVS 689
E L V L+ EK V LE+ + LQ +N SL +
Sbjct: 523 LRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTML 582
Query: 690 LQLEG---------------LERDNKQLDAENLELRRLVETMRFTSTKLAQMERENQQLE 734
+LEG L+ ++++D + + R + K+ Q + N +LE
Sbjct: 583 KELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELE 642
Query: 735 REKEELRKNV-DLLKALGKKSERLELSYQSVSAENLRLQQSLESSSHKTQTLESELGELE 793
++ EL + + LK + ++LE + + L + E S + ++L E +L
Sbjct: 643 QKVNELTGGLEETLKEKDQNDQKLE----KLMVQMKVLSEDKEVLSAEVKSLYEENNKLS 698
Query: 794 AERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKD-----------KKLLEKE-A 841
+E++ L RDLE ++K+ L++ + QLEK KLLE E
Sbjct: 699 SEKKQLSRDLEVFL--------SQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQV 750
Query: 842 KRLWQQV-------ELKDAVLDDSTAK-----LSAVEKESRALDKE---LARCRDAAGKL 886
++L+ + E+ V +DS K L AV + +++E LA RD K+
Sbjct: 751 QKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDE--KV 808
Query: 887 KELEKDNRDLTKQVTVHARTLTTLREDLVLEKL----KSQQLSSELDKLSQEL------- 935
ELEK+ + L ++ V L +L D EK+ + +++ SE + L +L
Sbjct: 809 LELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNAN 868
Query: 936 EKVGL-NRELLLQEDDSGSDTKYKILEGRNESA-------LKTTLAMKE-----EKIVLL 982
EK L N+ LL+Q ++ + E LK L KE +++LL
Sbjct: 869 EKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILL 928
Query: 983 EAQMEEKASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWG 1042
+ + + S+ S ++ L+++ E L + E + N K A K
Sbjct: 929 KDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKET 988
Query: 1043 PGHKEATMELLRVKDRAIELERN---------NAALQAEKQLLKEQLQHLETQNVTFSSQ 1093
KE L KD+ R+ N L+ EKQ EQL + + F +
Sbjct: 989 QTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQ--SEQLDVEKERANNFEHR 1046
Query: 1094 ILTLQKQSAFLQEHNTTLQTQTAKLQVEN-----STLSSQSAALTAQYTLLQNHHTAKET 1148
I L +Q N+TLQ +T E+ TL S + L Q +Q +
Sbjct: 1047 IEDLTRQL-----RNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDK 1101
Query: 1149 ENESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLK-----TLHRNLE 1203
E E+ + Q+EQ + + + E L +++ + + +++ +K T N+E
Sbjct: 1102 ELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNME 1161
Query: 1204 LEH-----KELGERHGDMLKRKAELEEREKVLTTEREALQQE---------------QRT 1243
+ KEL ++ + + +LE+ K+ ++E LQ+E +
Sbjct: 1162 IADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKI 1221
Query: 1244 NALAMGENQRL----RGELDRVNFLHHQLKGEYEELHAHTKELKTSLNNAQLELNRWQAR 1299
L + + L + E D + L LKGE E + K L E ++
Sbjct: 1222 KQLLVKTKKELADSKQAETDHL-ILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEH 1280
Query: 1300 FDELKEQHQ----TMDISLTKLDNHCELLSRLKGNL--EEENHHLLSQIQLLSQQNQMLL 1353
EQHQ +T L C + + E E++ + L Q+N+ +
Sbjct: 1281 LKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMS 1340
Query: 1354 EQNMENKEQYHEEQKQYIDKL 1374
+ E +Q E + ID+L
Sbjct: 1341 QAETEGAKQEREHLEMLIDQL 1361
Score = 83.6 bits (205), Expect = 2e-15
Identities = 154/676 (22%), Positives = 284/676 (42%), Gaps = 90/676 (13%)
Query: 783 QTLESELGELEAERQALRRDLEALRLANAQLEGAEKDR-KALEQEVAQLEKDKKLLEKEA 841
Q +S ELE E + LR + + + A +R AL E A+ E+ L+KE
Sbjct: 42 QKAKSRCTELEKEIEELRS--KPVTEGTGDIIKALTERLDALLLEKAETEQQCLSLKKEN 99
Query: 842 KRLWQQVELKDAVLDDSTAKLSAVE----KESRALDKELARCRDAAGKLKELEKDNRDLT 897
++ Q+VE + D+ +L KE L EL R + +D +L
Sbjct: 100 IKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRS------KYSEDKANLQ 153
Query: 898 KQVTVHARTLTTLREDLVLEKLKSQQLSSE-LDKLSQELEKV--GLNRELL-LQED-DSG 952
KQ+ T L E +LK Q S + + KL +E+EK+ G ++L LQ+ D+
Sbjct: 154 KQLEEAMNTQLELSE-----QLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDAT 208
Query: 953 SDTKYK-------ILEGRNESALKTTLAMKEEKIVLLEAQMEEKASLNRQLES------- 998
+D K + I+E ++ K +++EE + L EE L Q+E+
Sbjct: 209 TDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEA 268
Query: 999 ELQMLKKECETL-RQNQGEGQHLQNSFK----HPAGKTAASHQGKEAWGPGHKEATMELL 1053
E+ L + E L +Q + +++Q ++ + T+ ++Q + +E T
Sbjct: 269 EINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQ 328
Query: 1054 RVKDRAIELERNNAALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEHNTTLQT 1113
V ++ LE L+++ +LK+++ ++ + + K F + + +
Sbjct: 329 VVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHI-KDEFFHEREDLEFKI 387
Query: 1114 QTAKLQVENS-----TLSSQSAALTAQYTLLQNHHTAKETENESLQRQ-QEQLTAAYEAL 1167
L E L S+ A L Q+ H E +SL+ Q Q++++ E
Sbjct: 388 NELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNR---EVQSLKEQHQKEISELNETF 444
Query: 1168 LQDHE--------HLGTLHER----QSAEYEALIRQHSCLKTLHRNLELEHKELGERHG- 1214
L D E + L E+ Q + EA++ S L +E+ ELGE G
Sbjct: 445 LSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYES----LREIMEILQTELGESAGK 500
Query: 1215 ------DMLKRKA----ELEEREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFL 1264
M +++A EL+++ + TE++AL + N L GEN++L + + V L
Sbjct: 501 ISQEFESMKQQQASDVHELQQKLRTAFTEKDALLET--VNRL-QGENEKLLSQQELVPEL 557
Query: 1265 HHQLKGEYEELHAHTKELK---TSLNNAQLELNRWQARFDE----LKEQHQTMDISLTKL 1317
+ +K E+ + L T L + ++N D+ LK H+ MD K
Sbjct: 558 ENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKC 617
Query: 1318 DNHCELLSRLKGNLEEENHHLLSQIQLLSQQNQMLLEQNMENKEQYHEEQKQYIDKLNAL 1377
+ L+ L G E+ S+++ + LE+ ++ K+Q ++ ++ + ++ L
Sbjct: 618 EREERLILEL-GKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVL 676
Query: 1378 RRHKEKLEEKIMDQYK 1393
KE L ++ Y+
Sbjct: 677 SEDKEVLSAEVKSLYE 692
Score = 77.8 bits (190), Expect = 1e-13
Identities = 159/758 (20%), Positives = 324/758 (42%), Gaps = 102/758 (13%)
Query: 107 IGRDPLSGKSMEEIKKVLLLVLGCAVQCERKEEFIERIKQLDIETQAGIVAHIQEVTHNQ 166
+ DPLS +K++ + +C+ KEE I +IK + ++ + + + +E +
Sbjct: 938 VKNDPLSS-----VKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVK 992
Query: 167 ENVFDLQWLELPDVAPEELEALSRSMVLHLRRLIDQRDECTELIVDLTQERDYLQA---- 222
E + L+ E + LS SM R LI + L+++ ++ + L
Sbjct: 993 EELESLR---------SEKDQLSASM----RDLIQGAESYKNLLLEYEKQSEQLDVEKER 1039
Query: 223 ----QHPPSPIKSSSADSTPSPTSSLSSEDKQHLA-VELADTKARLRRVRQELEDKTEQL 277
+H + +ST +++S+++ LA +E + A+L V+ + + +
Sbjct: 1040 ANNFEHRIEDLTRQLRNST-LQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAM 1098
Query: 278 VDTRHEVDQLVLELQKVKQE----------NIQLAADARSARAYRDELDSLREKANRVER 327
VD E ++L E QK+K+ +QL + + + EL+ +++ A +
Sbjct: 1099 VDKELEAEKLQKE-QKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTL 1157
Query: 328 LELELT----RCKEKLHDVDFYKARMEELREDNIILIETKAMLEEQLTAARARGDKVHEL 383
+ +E+ KE + ++E+L ++ I + + L+E++T+ ++ V +
Sbjct: 1158 MNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQS---SVQQY 1214
Query: 384 EKENLQLKSKLHDLELDRDTDKKRIEELLEENMVLEIAQKQSMNESAHLGWELEQLSKNA 443
E++N ++K L + + D K+ E ++++L+ + K + S +Q +
Sbjct: 1215 EEKNTKIKQLLVKTKKEL-ADSKQAE---TDHLILQASLKGELEAS-------QQQVEVY 1263
Query: 444 DLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASLVLE-ESGLKCGELE-- 500
+ A S +++E + + ++ + Q + L++ + E E E
Sbjct: 1264 KIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESY 1323
Query: 501 --KENHQLSKKIEKLQTQLERE--KQSNQDLETLSEELIREKEQLQSDMETLKADKARQI 556
+ ++ L ++ K +Q E E KQ + LE L ++L K +LQ L+ + ++
Sbjct: 1324 KVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQL---KIKLQDSQNNLQIN-VSEL 1379
Query: 557 KDLEQEKDH-LNRAMWSLRERSQVSSEARMK--DVEKEN---KALH-QTVTEANGKLSQL 609
+ L+ E D L R L+E +E R K ++ EN K+ H QTV++ + L
Sbjct: 1380 QTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVL 1439
Query: 610 EFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGRLARKVTSLETATEKVEALEHESQ 669
R R L++ E + E L+++L +++ + +L E T + + +
Sbjct: 1440 RNSFRDQVRHLQE--EHRKTVETLQQQLSKMEAQLFQLKN-----EPTTRSPVSSQQSLK 1492
Query: 670 GLQLENRTLRKSLDTLQNVSLQLEGLE-RDNKQLDAENLELRRLVETMRFTSTKLAQMER 728
L+ T LD + EG+E D + + + + + L + + TKL E
Sbjct: 1493 NLRERRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLLNSPETKL---EP 1549
Query: 729 ENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSSHKTQTLESE 788
E KEEL V L + K ++ L + A N L + + + L+SE
Sbjct: 1550 PLWHAEFTKEEL---VQKLSSTTKSADHLNGLLRETEATNAILMEQI-------KLLKSE 1599
Query: 789 LGELE--AERQALRRDLEALRLANAQL----EGAEKDR 820
+ LE ER+ +LE L+ Q G+E++R
Sbjct: 1600 IRRLERNQEREKSAANLEYLKNVLLQFIFLKPGSERER 1637
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 169 bits (429), Expect = 2e-41
Identities = 254/1113 (22%), Positives = 463/1113 (41%), Gaps = 166/1113 (14%)
Query: 320 EKANRVERLELELTRCKEKLHDVDFYKARMEELREDNIILIETKAMLEEQLTAARAR--- 376
E + ++ E + K++L + A+ +EL E + L++ K L+ Q+ A
Sbjct: 845 ETEKEMATMKEEFQKTKDELAKSE---AKRKELEEKLVTLVQEKNDLQLQVQAESENLLD 901
Query: 377 -GDKVHELEKENLQLKSKLHDLELDRDTDKKRIEELLEENMVLEIAQKQSMNESAHLGWE 435
++ +L K QL++K+ ++ + +++ EL + LE + + L
Sbjct: 902 AEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELT 961
Query: 436 LEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASLVLEESGLK 495
L ++ K ++ K+ EL+ + I KL +E ++LQ Q D L EE K
Sbjct: 962 LAKVEKEKHATENKVKNLTEELSGLDET-IAKLTREKKALQEAHQQALD-DLQAEED--K 1017
Query: 496 CGELEKENHQLSKKIEKLQTQLEREKQSNQDLET----------LSEELIREKE------ 539
L K +L +++E L++ LE+EK+ DLE L++E I + E
Sbjct: 1018 VNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQL 1077
Query: 540 ------------QLQS---DMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEAR 584
QLQS D +TL ++IK+L+ + L + + R ++ +E +
Sbjct: 1078 DERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERA-TRAKTEKQ 1136
Query: 585 MKDVEKENKALHQTVTEANGKLS-QLEFEKRQ------LHRDLEQAK------------- 624
D +E + L + + EA G S Q+E K++ L RDLE+A
Sbjct: 1137 RSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKK 1196
Query: 625 ------EKGERAEKLERELQRLQEENGRLARKVTSLETATEKVE-----------ALEHE 667
E GE+ + L+R Q+L++E ++ L ++ E V LE +
Sbjct: 1197 HADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQ 1256
Query: 668 SQGLQLENRTLRKSLD--TLQNVSLQLEGLERDNKQLDAENLELRRLVETMRFTSTKLAQ 725
+ +N +++SL T Q LQ E E + + E++ + FT Q
Sbjct: 1257 LSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQ----Q 1312
Query: 726 MERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSS------ 779
E +QLE E + L++ + L Y+ LQ++L ++
Sbjct: 1313 TEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQW 1372
Query: 780 ---HKTQTLESELGELEAERQALRRDL----EALRLANAQLEGAEKDRKALEQEVAQLEK 832
++T ++ ELE ++ L + L E + NA+ EK ++ L+ EV L
Sbjct: 1373 RTKYETDAIQ-RTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMV 1431
Query: 833 DKKLLEKEAKRLWQQVELKDAVL-------DDSTAKLSAVEKESRALDKELARCRDAAGK 885
D + A L ++ D VL ++S A+L A KESR+L EL + ++A +
Sbjct: 1432 DVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEE 1491
Query: 886 L-----------KELEKDNRDLTKQVTVHARTLTTL---REDLVLEKLKSQQLSSELDKL 931
K LE++ DLT+Q+ + +T+ L R+ + LEK Q E +
Sbjct: 1492 ALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAA 1551
Query: 932 SQELEKVGLNRELLLQEDDSGSDTKYKILEGRNESALKTTLAMKEEKIVLLEAQMEEKA- 990
+ E L +L L + S D K +A K+E+I L+ +
Sbjct: 1552 LEHEEAKILRIQLELTQVKSEIDRK---------------IAEKDEEIEQLKRNYQRTVE 1596
Query: 991 SLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEATM 1050
++ L++E++ + ++ +G+ ++ H + A + + + K+ +
Sbjct: 1597 TMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQL 1656
Query: 1051 EL---LR----VKDRAIELERNNAALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAF 1103
L LR +K++ +ER LQAE + L+ L+ E ++L ++
Sbjct: 1657 HLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQL 1716
Query: 1104 LQEHNTT-------LQTQTAKLQ--VENSTLSSQSAALTAQYTLLQNHHTAKETENE-SL 1153
L NT+ L+T +LQ VE+++ +++A A+ + A+E + E
Sbjct: 1717 LHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDT 1776
Query: 1154 QRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGERH 1213
E++ E ++D +H L E + + +Q L+T R LE E + +++
Sbjct: 1777 SAHLERMKKNLEQTVKDLQH--RLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKN 1834
Query: 1214 GDMLKRKAELEEREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQLKGEYE 1273
+ +K + E R K LT + E E R N L RL+ +D++ K + E
Sbjct: 1835 TESVKGLRKYERRVKELTYQSE----EDRKNVL------RLQDLVDKLQVKVKSYKRQAE 1884
Query: 1274 ELHAHTKELKTSLNNAQLELNRWQARFDELKEQ 1306
E T AQ EL + R D + Q
Sbjct: 1885 EADEQANAHLTKFRKAQHELEEAEERADIAESQ 1917
Score = 158 bits (399), Expect = 6e-38
Identities = 215/983 (21%), Positives = 409/983 (41%), Gaps = 128/983 (13%)
Query: 469 EKENQSLQSTIQGLRDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLE 528
EKE +++ Q +D L +S K ELE++ L ++ LQ Q++ E ++ D E
Sbjct: 847 EKEMATMKEEFQKTKDE---LAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAE 903
Query: 529 TLSEELIREKEQLQS----------DMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQ 578
++LI+ K QL++ D E + A+ + + LE E L + + L
Sbjct: 904 ERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDL----- 958
Query: 579 VSSEARMKDVEKENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERA----EKLE 634
E + VEKE A V +LS L+ +L R+ + +E ++A + E
Sbjct: 959 ---ELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEE 1015
Query: 635 RELQRLQEENGRLARKVTSLETATEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEG 694
++ L + +L ++V LE++ E+ + L + L+ R L L Q L
Sbjct: 1016 DKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVD---LERNKRKLEGDLKLAQESILD--- 1069
Query: 695 LERDNKQLD----AENLELRRLVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKAL 750
LE D +QLD ++ E +L + T Q +++ ++L+ EEL + ++ +A
Sbjct: 1070 LENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERAT 1129
Query: 751 GKKSERLELSYQSVSAENLRLQQSLESSSHKTQTLESELGELEAERQALRRDLEALRLAN 810
K+E+ Y + E L + LE + T T + EAE LRRDLE L +
Sbjct: 1130 RAKTEKQRSDY---ARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQH 1186
Query: 811 AQLEGAEKDRKA-----LEQEVAQLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAV 865
+ A + + A L +++ L++ K+ LEKE +++ + ++ + + +
Sbjct: 1187 EAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANL 1246
Query: 866 EKESRALDKELARCRDAAGKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLS 925
EK R L+ +L+ +A GK +E+++ +LT Q +L
Sbjct: 1247 EKICRTLEDQLS---EARGKNEEIQRSLSELTTQ---------------------KSRLQ 1282
Query: 926 SELDKLSQELEKVGLNRELLLQEDDSGSDTKYKILEGRNESALKTTLAMKEEKIVLLEAQ 985
+E +LS++LE+ K I+ + S T +E L+ Q
Sbjct: 1283 TEAGELSRQLEE------------------KESIVSQLSRSKQAFTQQTEE-----LKRQ 1319
Query: 986 MEEKASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTAAS-HQGKEAWGPG 1044
+EE+ L LQ + +C+ LR+ E Q + + K + Q + +
Sbjct: 1320 LEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETD 1379
Query: 1045 HKEATMEL--------LRVKDRAIELERNN---AALQAEKQLLKEQLQHLETQNVTFSSQ 1093
+ T EL R++D ++E N A+L+ KQ L+ +++ L +S
Sbjct: 1380 AIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSL 1439
Query: 1094 ILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETENESL 1153
L K+ + +T+ + Q E +S +L+ + L+N + + E++
Sbjct: 1440 AAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETV 1499
Query: 1154 QRQQEQLTAAYEALLQDHEHLG-TLHERQSAEYEALIRQHSCLKTLHR-NLELEHK---- 1207
+R+ + L L + G T+HE + + + + + L LEH+
Sbjct: 1500 KRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKI 1559
Query: 1208 -----ELGERHGDMLKRKAELEER--------EKVLTTEREALQQEQRTNALAMGENQRL 1254
EL + ++ ++ AE +E ++ + T + AL E R+ A+ +++
Sbjct: 1560 LRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKM 1619
Query: 1255 RGELDRVNFLHHQLKGEYEELHAHTKELKTSLNNAQLELNRWQARFDELKEQ-------H 1307
G+L+ + + E H + ++ L + QL L+ ++LKEQ
Sbjct: 1620 EGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRA 1679
Query: 1308 QTMDISLTKLDNHCELLSRLKGNLEEENHHLLSQIQLLSQQNQMLLEQNMENKEQYHEEQ 1367
+ + +L E R + E+E ++QLL QN L+ + + + Q
Sbjct: 1680 NLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQ 1739
Query: 1368 KQYIDKLNALRRHKEKLEEKIMD 1390
+ D R +EK ++ I D
Sbjct: 1740 SEVEDASRDARNAEEKAKKAITD 1762
Score = 121 bits (303), Expect = 8e-27
Identities = 207/934 (22%), Positives = 391/934 (41%), Gaps = 132/934 (14%)
Query: 247 EDKQHLAVELADTKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADAR 306
ED+Q L ++ L+ +ELE++ E TR K +++ A +
Sbjct: 1096 EDEQTLGLQFQKKIKELQARIEELEEEIEAERATR----------AKTEKQRSDYAREL- 1144
Query: 307 SARAYRDELDSLREKANRVERLELELTRCKEKLHDVDFYKARMEELREDNIILIETKAML 366
+EL E+A V ++EL + +E +F K R + +E +
Sbjct: 1145 ------EELSERLEEAGGVTSTQIELNKKRE----AEFLKLRRD---------LEEATLQ 1185
Query: 367 EEQLTAA--RARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIEELLEENMVLEIAQKQ 424
E + AA + D V EL ++ L+ LE ++ K I++L + +E K
Sbjct: 1186 HEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDL---SSSMESVSKS 1242
Query: 425 SMNESAHLGWELEQLSKNAD--LSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGL 482
N LE++ + + LS+A K NE + +L + LQ+ L
Sbjct: 1243 KAN--------LEKICRTLEDQLSEARGK------NEEIQRSLSELTTQKSRLQTEAGEL 1288
Query: 483 RDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQ 542
S LEE +L + +++ E+L+ QLE E ++ L + + + L+
Sbjct: 1289 ---SRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLR 1345
Query: 543 SDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEA 602
E + KA +L++ N + R + + + R +++E+ K L Q + ++
Sbjct: 1346 EQYEEEQEGKA----ELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDS 1401
Query: 603 -------NGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGR-LARKVTSL 654
N K + LE K++L ++E ERA L L + Q + LA T
Sbjct: 1402 EEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKC 1461
Query: 655 ETATEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVE 714
E + ++EA ES+ L E L K + + QLE ++R+NK L+ E+ L E
Sbjct: 1462 EESQAELEASLKESRSLSTE---LFKLKNAYEEALDQLETVKRENKNLEQ---EIADLTE 1515
Query: 715 TMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQS 774
+ + ++E+ +Q+E EK +++ + E E + + A+ LR+Q
Sbjct: 1516 QIAENGKTIHELEKSRKQIELEKADIQLAL----------EEAEAALEHEEAKILRIQ-- 1563
Query: 775 LESSSHKTQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDK 834
LE + K++ ++ ++ E + E + L+R+ + E + AL+ EV
Sbjct: 1564 LELTQVKSE-IDRKIAEKDEEIEQLKRNYQ---------RTVETMQSALDAEVRS----- 1608
Query: 835 KLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDNR 894
EA RL +++E L++ +LS +++ K L R G+LK+ +
Sbjct: 1609 ---RNEAIRLKKKME---GDLNEIEIQLSHANRQAAETLKHL---RSVQGQLKDTQLHLD 1659
Query: 895 DLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSD 954
D R L+E L + + ++ L +E+++L LE+ R+L QE S+
Sbjct: 1660 DA-------LRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQE-LLDSN 1711
Query: 955 TKYKILEGRNESALKTTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLKKE----CETL 1010
+ ++L +N S + T + E ++ L++++E+ + R E + + + E L
Sbjct: 1712 ERVQLLHTQNTSLIHTKKKL-ETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEEL 1770
Query: 1011 RQNQGEGQHLQNSFKHPAGKTA-ASHQGKEAWGPGHKEATMELLRVKDRAIELERNNAAL 1069
++ Q HL+ K+ H+ EA K ++ +++ R ELE L
Sbjct: 1771 KKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELE---FEL 1827
Query: 1070 QAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQS 1129
+ E++ E ++ L + ++ L QS +++ LQ KLQV+ + Q+
Sbjct: 1828 EGEQKKNTESVKGLR----KYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQA 1883
Query: 1130 AALTAQYTLLQNHHTAKETENESLQRQQEQLTAA 1163
Q H T L+ +E+ A
Sbjct: 1884 EEADEQ---ANAHLTKFRKAQHELEEAEERADIA 1914
Score = 57.8 bits (138), Expect = 1e-07
Identities = 115/542 (21%), Positives = 221/542 (40%), Gaps = 104/542 (19%)
Query: 76 QNLTILVRNIKTYYQEVLQQLIVMNLPNVLMIGRDPLSGKSMEEIKKVLLLVLGCAVQCE 135
++L+ + +K Y+E L QL + N K++E+ ++ L A +
Sbjct: 1476 RSLSTELFKLKNAYEEALDQLETVKREN-----------KNLEQ--EIADLTEQIAENGK 1522
Query: 136 RKEEFIERIKQLDIETQAGIVAHIQE----VTHNQENVFDLQWLELPDVAPEELEALSRS 191
E + KQ+++E +A I ++E + H + + +Q LEL V E
Sbjct: 1523 TIHELEKSRKQIELE-KADIQLALEEAEAALEHEEAKILRIQ-LELTQVKSE-------- 1572
Query: 192 MVLHLRRLIDQRDECTELIVDLTQERDYLQAQHPPSPIKSSSADSTPSPTSSLSSEDKQ- 250
+ R I ++DE E + +R+Y Q ++S+ S ++ + K
Sbjct: 1573 ----IDRKIAEKDEEIEQL-----KRNY---QRTVETMQSALDAEVRSRNEAIRLKKKME 1620
Query: 251 -----------HLAVELADTKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQKVKQENI 299
H + A+T LR V+ +L+D L D + L +L V++
Sbjct: 1621 GDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRAN 1680
Query: 300 QLAADARSARAYRDELDSLREKANRVERLELELTRCKEKLHDVDFYKARMEELREDNIIL 359
L A+ RA ++ + R+ A E EL E R++ L N L
Sbjct: 1681 LLQAEVEELRATLEQTERARKLA------EQELLDSNE----------RVQLLHTQNTSL 1724
Query: 360 IETKAMLEEQLTAARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIEELLEENMVLE 419
I TK LE L +QL+S++ D D +++ ++ + + ++
Sbjct: 1725 IHTKKKLETDL-----------------MQLQSEVEDASRDARNAEEKAKKAITDAAMMA 1767
Query: 420 IAQKQSMNESAHLGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTI 479
K+ + SAH LE++ KN + + K L+E + +K+ Q L++ I
Sbjct: 1768 EELKKEQDTSAH----LERMKKNL---EQTVKDLQHRLDEAEQLALKGGKKQIQKLETRI 1820
Query: 480 QGLRDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEEL----- 534
R+ LE K E K + +++++L Q E ++++ L+ L ++L
Sbjct: 1821 ---RELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVK 1877
Query: 535 ----IREKEQLQSDMETLKADKAR-QIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVE 589
E+ Q++ K KA+ ++++ E+ D + LR +++ + +RM E
Sbjct: 1878 SYKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAESQVNKLRAKTRDFTSSRMVVHE 1937
Query: 590 KE 591
E
Sbjct: 1938 SE 1939
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 169 bits (428), Expect = 3e-41
Identities = 330/1623 (20%), Positives = 640/1623 (39%), Gaps = 259/1623 (15%)
Query: 201 DQRDECTELIVDLTQERDYL-QAQHPPSPIKSSSADSTPSPTSSLSSE----------DK 249
+++ + + LI DL L QA+ + + +SL+SE
Sbjct: 459 EEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQD 518
Query: 250 QHLAVELADTKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSAR 309
Q LA K + ++ Q L+ + + RH+V+QL L++ +Q+ ++A + R
Sbjct: 519 QELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATR 578
Query: 310 AYRDELDSLREKANRVERLELELTRCKEKLHDVDFYKARMEELREDNIILIETKAMLEEQ 369
D ++ A E E L + D ++E L ++ +E +L++Q
Sbjct: 579 Q-----DHAQQLATAAEEREASL-------RERDAALKQLEALEKEKAAKLE---ILQQQ 623
Query: 370 LTAARARGDK----VHELEKENLQLKSKLHDLELDRDTDKKRIEELLEENMVLEI---AQ 422
L A D V + ++E +L K+ +L+ +T ++ E + LE+ ++
Sbjct: 624 LQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSE 683
Query: 423 KQSMNESAHLGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGL 482
+Q E + E +QL + S K L E EK
Sbjct: 684 QQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEE---------EK------------ 722
Query: 483 RDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQ 542
R A+ LEE EL+ E L ++ ++ + +LE E+ + LE ++L E Q
Sbjct: 723 RRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQL---GEAHQ 779
Query: 543 SDMETLKADKARQIK---DLEQEKDHLNRAMWSLRERSQVSSEA----------RMKDVE 589
++ E L+ + A + E E + L + + + RER + S + ++ ++
Sbjct: 780 AETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLK 839
Query: 590 KENKALHQTVTEANGKL------SQLEFEKRQ---------LHRDLEQAKEKGERAEKLE 634
+E + Q + EA K+ S+L+ ++Q L R L+Q +EK RA+KL
Sbjct: 840 EECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLA 899
Query: 635 RELQRLQEENGRLARKVTSLETATEKVEALEHESQGLQLENRTLRKS------LDTLQ-- 686
+L LQE+ +++V LET K + E+ +L R L+ Q
Sbjct: 900 DDLSTLQEKMAATSKEVARLETLVRKAGE-QQETASRELVKEPARAGDRQPEWLEEQQGR 958
Query: 687 ---NVSLQLEGLERDNKQLDAENLELRR-LVETMRFTSTKLAQMERENQQLEREKEELRK 742
+ L+ +ER+ +Q+ E LR L+E+ + Q ERE +L +E+ +
Sbjct: 959 QFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQA 1018
Query: 743 NVDLLKALGKKSE-RLELSYQSVSAENLRLQQSLESSSHKTQTLESELGELEAERQALRR 801
++ L KA + E RL+ + E LQ++L + + + + EL +L A +
Sbjct: 1019 DLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIK 1078
Query: 802 DLEALRLANAQLE--------------GAEKDR-----------KALEQEVAQLEKDKKL 836
+LE LR QL+ GA+ + +AL EV++LE+ +
Sbjct: 1079 ELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQK 1138
Query: 837 LEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDNRDL 896
+++A L + +E + A + + L ++ + +EL + A L +++
Sbjct: 1139 QQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSA---LASAQRELAAF 1195
Query: 897 TKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSDTK 956
+V H++ + + + ++++ +S + L +E+ LNR++L +E +S +
Sbjct: 1196 RTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSI--LNRQVLEKEGESKELKR 1253
Query: 957 YKILEGRNESALKTTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLKKECETLRQNQGE 1016
+ E L+ L + + + A+ E++S R+ E+Q L++E E R
Sbjct: 1254 LVMAESEKSQKLEERLRLLQAETASNSARAAERSSALRE---EVQSLREEAEKQRV---A 1307
Query: 1017 GQHLQNSFKHPAGKTAASHQGKEAWGPG--HKEATM---------------ELLRVKDRA 1059
++L+ A + Q +AW KE + ELL K
Sbjct: 1308 SENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLC 1367
Query: 1060 IELERNNAALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEHNTTLQTQTAKLQ 1119
+L+ AA AEK+ +E+L+ + +++L Q++ L L+ + A+ +
Sbjct: 1368 QQLQAEQAA--AEKRH-REELEQSKQAAGGLRAELLRAQRELGEL----IPLRQKVAEQE 1420
Query: 1120 VENSTLSSQSAALTAQYTLLQNHHTAKETENESL--------QRQQEQLTAAYEALLQDH 1171
L ++ A+ Q ++L+ H EN L Q + +L A E +Q+
Sbjct: 1421 RTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQEL 1480
Query: 1172 EHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAELEEREKVLT 1231
+ E + AE + + + R LE+ + +L+ + +E + LT
Sbjct: 1481 AAVRADAETRLAEVQREAQSTA------RELEVMTAKYEGAKVKVLEERQRFQEERQKLT 1534
Query: 1232 TEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQ------------------LKGEYE 1273
+ E L+ QR + E + + D+ + + Q L+ +
Sbjct: 1535 AQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLN 1594
Query: 1274 ELHAHTKELKTSLNNAQLELNRWQARFDELKEQHQTMDISLTKLDNHCELLSRLKGNLEE 1333
EL A + + + + +L++ + + +D K+Q+Q + L L+ L++
Sbjct: 1595 ELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLE-----------QLQK 1643
Query: 1334 ENHHLLSQIQLLSQQNQMLLEQNMENKEQYHEEQKQYIDKLNALRRHKEKLEEKIMDQYK 1393
EN L ++ + L + L + ++ KE + + ++ +L ++++ D K
Sbjct: 1644 ENKELRAEAERLGHE---LQQAGLKTKEA-EQTCRHLTAQVRSLEAQVAHADQQLRDLGK 1699
Query: 1394 FYDPPPKKKNHWIGAKALVKLIKPKKEGSRERLKSTVDSPPWQLESSDPASPAASQPLRS 1453
F + +K ++ ++ +L ++DS E P S + P R+
Sbjct: 1700 F--------------QVATDALKSREPQAKPQLDLSIDSLDLSCEEGTPLSITSKLP-RT 1744
Query: 1454 QAENPDTPALGSNCAEERDAHNGSVGKGPGDLKPKRGSPHRGSLDRTDASTDLAMRSWPS 1513
Q + P ++ +R L PK S A + + S
Sbjct: 1745 QPDGTSVPGEPASPISQR-------------LPPKVESLESLYFTPIPARSQAPLESSLD 1791
Query: 1514 ELGSRTCSTSATTTAPSNSTPIARHPGRTKGYNSDDNLCEPSLEFEVPNHRQYVSR--PS 1571
LG + T + T + TK + + E + N Y +R P+
Sbjct: 1792 SLGDVFLDSGRKTRSARRRTTQIINITMTKKLDVE--------EPDSANSSFYSTRSAPA 1843
Query: 1572 SLESSRNTSSNSSPLNLKGSSEQLHGRSESFSSEDLIPSRDLATLPREASTPGRNALGRH 1631
S S R TSS S L GS + +G S S P+ + +A GR+
Sbjct: 1844 SQASLRATSSTQSLARL-GSPD--YGNSALLSLPGYRPTTRSSARRSQAGVSSGAPPGRN 1900
Query: 1632 EYPLPRNGPLPQ---------EGAQKRGTAPPYVGV-RPCSASPSSEMVTLEEFLEESNR 1681
+ + P+ E Q+ PP++ P + PS + T+ + EE
Sbjct: 1901 SFYMGTCQDEPEQLDDWNRIAELQQRNRVCPPHLKTCYPLESRPSLSLGTITD--EEMKT 1958
Query: 1682 SSP 1684
P
Sbjct: 1959 GDP 1961
Score = 164 bits (414), Expect = 1e-39
Identities = 323/1447 (22%), Positives = 568/1447 (39%), Gaps = 235/1447 (16%)
Query: 102 PNVLMIGRDPLSGKSMEEIKKVLLLVLGCAVQCERKEEFIERIKQLDIETQAGIVA---- 157
P L+ + L G +E K +LL+ + + ++ +Q + + QA +
Sbjct: 78 PECLVSAQKVLEGSELELAKMTMLLLYHSTMSSKSPRDW----EQFEYKIQAELAVILKF 133
Query: 158 ---HIQEVTHNQENVFDLQWLELPDVA----PEELEALSRSMVLHLRRLIDQRDECTELI 210
H + N++ LQ +P PEEL S +R L Q+ +
Sbjct: 134 VLDHEDGLNLNEDLENFLQKAPVPSTCSSTFPEELSPPSHQAKREIRFLELQK------V 187
Query: 211 VDLTQERDYLQAQHPPSPIKSSSADSTPSPTSSLSSEDKQHLAVELADTKARLRRVRQEL 270
+ ++L P SP+ D +P + KQ LAD ++ + EL
Sbjct: 188 ASSSSGNNFLSGS-PASPM----GDILQTPQFQMRRLKKQ-----LADERSNRDELELEL 237
Query: 271 EDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSARAYRDELDSLREKANRVE-RLE 329
+ + L + ++ + + ++ N + AA + EL+ LR+K + RL
Sbjct: 238 AENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPK----ELEELRDKNESLTMRLH 293
Query: 330 LELTRCKEKLHDVDFYKARMEELREDNIILIETKAMLEEQLTAARARGDKVHELEKENLQ 389
L +C++ + ++ +L E+N L L E + + D ++EL +E+
Sbjct: 294 ETLKQCQDLKTEKSQMDRKINQLSEENGDL---SFKLREFASHLQQLQDALNELTEEH-- 348
Query: 390 LKSKLHDLELDRDTD-KKRIEELLEENMVLEIAQKQSMNESAHLGWELEQLSKNADLSDA 448
SK L++ +K + L++ LE + + + L L QL N
Sbjct: 349 --SKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKG 406
Query: 449 SRKSFVFELNECASSRILKLEKENQSLQSTIQ------GLRDASLVLEESGLKCGELEKE 502
V +L E L N LQ+ ++ G ++A L+ E G E+E
Sbjct: 407 EVLGDVLQL-ETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAER-----GHFEEE 460
Query: 503 NHQLSKKIEKLQTQLEREKQSNQDLETLSE----ELIREKEQLQSDMETLKADKARQIKD 558
QLS I LQ+ + Q+ ++LE S+ L + L S++ TL A +Q ++
Sbjct: 461 KQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQE 520
Query: 559 L----EQEKDHLNRAMWSLRERSQVSS----------------EARMKDVEKENKALHQT 598
L +Q K+ + +L+++ Q S E ++K+V ++ +A Q
Sbjct: 521 LAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQD 580
Query: 599 -----VTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQ--------------R 639
T A + + L L + KEK + E L+++LQ +
Sbjct: 581 HAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQ 640
Query: 640 LQEENGRLARKVTSLETATEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDN 699
Q E L+RKV L+ E +HE+Q E L L + Q + + E + ++
Sbjct: 641 AQREKAELSRKVEELQACVETARQEQHEAQAQVAE---LELQLRSEQQKATEKERVAQEK 697
Query: 700 KQLDAENLELRRLVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGK------K 753
QL +L+ L E+++ T +E E ++ EE ++ + LKA + K
Sbjct: 698 DQLQE---QLQALKESLKVTK---GSLEEEKRRAADALEEQQRCISELKAETRSLVEQHK 751
Query: 754 SERLELSYQSVSAENL--RLQQSLESSSHKTQTLESELGELEAERQALRRDLEAL----- 806
ER EL + + L RLQQ E+ +T+ L EL E A + + E L
Sbjct: 752 RERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVA 811
Query: 807 ----RLANAQLEGA-----------------EKDRKALE---QEVAQLEKDKKL------ 836
R ++Q E A EK R+ L+ ++VA +E +L
Sbjct: 812 AWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQ 871
Query: 837 -----LEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKL-KELE 890
L R QQV+ K+ LS ++++ A KE+AR K ++ E
Sbjct: 872 NELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQE 931
Query: 891 KDNRDLTKQVT------------VHARTLTTLREDLVLEKLKSQQLSSELDKL------- 931
+R+L K+ R + + L + +++Q+ +EL++L
Sbjct: 932 TASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMES 991
Query: 932 --SQELEKVGLNRELLLQEDDSGSDTKYKILE--GRNESALKTTLAMKEEKIVLLEAQ-- 985
Q+ E+ RE+ + G LE R E ++ A+ E+++ Q
Sbjct: 992 QGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEA 1051
Query: 986 ----MEEKASLNRQLESELQMLK----KECETLRQ--NQGEGQHLQNSFKHPAGKTAASH 1035
+ EK +++L ++L+ L+ KE E LRQ Q + Q + +H +G A S
Sbjct: 1052 LAHALTEKEGKDQEL-AKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSE 1110
Query: 1036 QGKEAWGPGHKEATMELLRVKDRAIELERNNAALQAEKQLLKEQLQHLETQNVTFSSQIL 1095
G K +E LR + +LE+ Q + L+ L+ S +
Sbjct: 1111 AAGRTEPTGPK---LEALRAE--VSKLEQQCQKQQEQADSLERSLEAERASRAERDSALE 1165
Query: 1096 TLQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETENESLQR 1155
TLQ Q L+ + +L S L+S L A T +Q+H A++ + R
Sbjct: 1166 TLQGQ----------LEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVAR 1215
Query: 1156 QQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGER--- 1212
+++ +L+ E ++ RQ E E ++ LK L + ++L ER
Sbjct: 1216 GRQE-AERKNSLISSLEEEVSILNRQVLEKEGESKE---LKRLVMAESEKSQKLEERLRL 1271
Query: 1213 -HGDMLKRKAELEEREKVLTTEREALQQEQRTNALAMGEN--QRLRGELDRVNFLHHQLK 1269
+ A ER L E ++L++E +A EN Q L + +R L +LK
Sbjct: 1272 LQAETASNSARAAERSSALREEVQSLREEAEKQRVA-SENLRQELTSQAERAEELGQELK 1330
Query: 1270 GEYEELHAHTKELKTSLNNAQLELNRWQARFDELK------EQHQTMDISLTKLDNHCEL 1323
E+ + + +L+ QLE QA EL +Q Q + K H E
Sbjct: 1331 AWQEKFF----QKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEK--RHREE 1384
Query: 1324 LSRLK---GNLEEENHHLLSQIQLLSQQNQMLLEQNMENKEQYHEEQKQYIDKLNALRRH 1380
L + K G L E ++ L Q + EQ +Q E+ Y ++L+ L++
Sbjct: 1385 LEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQE-RTAQQLRAEKASYAEQLSMLKKA 1443
Query: 1381 KEKLEEK 1387
L E+
Sbjct: 1444 HGLLAEE 1450
Score = 145 bits (365), Expect = 5e-34
Identities = 252/1145 (22%), Positives = 474/1145 (41%), Gaps = 162/1145 (14%)
Query: 135 ERKEEFIERIKQLDIETQAGIVAHIQEVTHNQENVFDLQWL-ELPDVAPEELEALSRSMV 193
E + +E +Q E QA + ++ Q+ + + + + D E+L+AL S+
Sbjct: 653 EELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLK 712
Query: 194 L-------HLRRLIDQRDECTELIVDLTQERDYLQAQHPPSPIKSSSADSTPSPTSSLSS 246
+ RR D +E I +L E L QH + + + L +
Sbjct: 713 VTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKR---ERKELEEERAGRKGLEA 769
Query: 247 EDKQHLAVELADTKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQ--KVKQENIQLAAD 304
+Q A+T+ +R+EL + E +QLV E+ + + E+ Q +
Sbjct: 770 RLQQLGEAHQAETEV----LRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQ-QEE 824
Query: 305 ARSARAYRDELDSLREKANRVERLELELTRCKEKLHDVDFYKARMEELREDNIILIETKA 364
A+ ++++L +L+E+ E+ EL KEK+ ++ + + ++ R+ N L E A
Sbjct: 825 AQYGAMFQEQLMTLKEEC---EKARQELQEAKEKVAGIESH-SELQISRQQNE-LAELHA 879
Query: 365 MLEEQLTAARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIEELLEE-NMVLEIAQK 423
L L + + + +L + L+ K+ + R+E L+ + E A +
Sbjct: 880 NLARALQQVQEKEVRAQKLADDLSTLQEKM----AATSKEVARLETLVRKAGEQQETASR 935
Query: 424 QSMNESAHLG-----WELEQLSKNADLSDASRKSFVFEL----NECASSRILKLEKENQS 474
+ + E A G W EQ + + A+ ++ E NE R +E + Q
Sbjct: 936 ELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQ 995
Query: 475 LQSTIQGLRDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEEL 534
+ Q R+ + + +E G +L E ++ +LQ L ++ L+
Sbjct: 996 QEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHA 1055
Query: 535 IREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKA 594
+ EKE ++ L+ +A QIK+LE+ L + + L+E ++ EKE+ +
Sbjct: 1056 LTEKEGKDQELAKLRGLEAAQIKELEE----LRQTVKQLKE--------QLAKKEKEHAS 1103
Query: 595 LHQTVTEANGKLS----QLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGRLARK 650
+EA G+ +LE + ++ + +Q +++ E+A+ LER L+ E A +
Sbjct: 1104 GSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERS---LEAERASRAER 1160
Query: 651 VTSLET----ATEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQLE----GLERDNKQL 702
++LET EK + L H L R L +Q+ S + + R ++
Sbjct: 1161 DSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEA 1220
Query: 703 DAENLELRRLVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQ 762
+ +N + L E + + ++ + E E+++L+R L+ A +KS++LE
Sbjct: 1221 ERKNSLISSLEEEVSILNRQVLEKEGESKELKR----------LVMAESEKSQKLE---- 1266
Query: 763 SVSAENLRLQQSLESSSHKTQTLESELGELEAERQALRRDLEALRLAN--------AQLE 814
E LRL Q+ E++S+ + E L E Q+LR + E R+A+ +Q E
Sbjct: 1267 ----ERLRLLQA-ETASNSARAAERS-SALREEVQSLREEAEKQRVASENLRQELTSQAE 1320
Query: 815 GAE---KDRKALEQEVAQLEKDKKLLEKE-------------AKRLWQQVELKDAVLDDS 858
AE ++ KA +++ Q E+ L+ E AK L QQ++
Sbjct: 1321 RAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQ--------- 1371
Query: 859 TAKLSAVEKESRALDKELARCRDAAGKLK-ELEKDNRDLTKQVTVHARTLTTLREDLVLE 917
A+ +A EK R +EL + + AAG L+ EL + R+L + L LR+ + +
Sbjct: 1372 -AEQAAAEKRHR---EELEQSKQAAGGLRAELLRAQRELGE--------LIPLRQKVAEQ 1419
Query: 918 KLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSDTKYKILEGRNESALKTTLAMKEE 977
+ +QQL +E +++L + LL +E+ G E A ++ E
Sbjct: 1420 ERTAQQLRAEKASYAEQLSMLKKAHGLLAEEN-----------RGLGERANLGRQFLEVE 1468
Query: 978 KIVLLEAQMEEKASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTAASHQG 1037
E ++E A++ E+ L E R+ Q + L+ G +
Sbjct: 1469 LDQAREKYVQELAAVRADAETRL------AEVQREAQSTARELEVMTAKYEGAKVKVLEE 1522
Query: 1038 KEAWGPGHKEATMELLRVKDRAIELERNNAALQAEKQLLKEQLQHLETQNVTFSSQILTL 1097
++ + ++ T ++ +E+ + Q E+ L ++L + + ++ +
Sbjct: 1523 RQRFQEERQKLTAQV-----EQLEVFQREQTKQVEE--LSKKLADSDQASKVQQQKLKAV 1575
Query: 1098 QKQSAFLQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETENESLQ--- 1154
Q Q Q+ LQ Q +LQ + S + Q + H+ AK+ +N+ LQ
Sbjct: 1576 QAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQL 1635
Query: 1155 RQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGERHG 1214
R EQL + L + E LG HE Q A + + +C H ++ E H
Sbjct: 1636 RSLEQLQKENKELRAEAERLG--HELQQAGLKTKEAEQTC---RHLTAQVRSLEAQVAHA 1690
Query: 1215 DMLKR 1219
D R
Sbjct: 1691 DQQLR 1695
Score = 112 bits (280), Expect = 4e-24
Identities = 195/868 (22%), Positives = 349/868 (40%), Gaps = 89/868 (10%)
Query: 672 QLENRTLRKSLDTLQNVSLQLEGLERDNKQL----DAENLELRRLVETMRFTSTKLAQME 727
Q + R L+K L ++ +LE +N++L DA+ +++ ++ + + K A
Sbjct: 213 QFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASP 272
Query: 728 RENQQLE--REKEE-----LRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSSH 780
E ++LE R+K E L + + + L + +++ +S EN L L +
Sbjct: 273 LEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFAS 332
Query: 781 KTQTLESELGELEAER-QALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEK 839
Q L+ L EL E +A + LE +L A +D+K LE++ L+ LE+
Sbjct: 333 HLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEE 392
Query: 840 EAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDNRDLTKQ 899
+L + + +L +++E+ L + + A ++ E E+ ++
Sbjct: 393 HLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQ-ARVEMLETERGQQEAK-- 449
Query: 900 VTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDS-GSDTKYK 958
L R EK QQLSS + L + + +E L Q + G+ +
Sbjct: 450 -------LLAERGHFEEEK---QQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQ 499
Query: 959 ILEGRNE-SALKTTLAMKEEKIVLLEAQMEEK----ASLNRQLESELQMLKKECETLRQN 1013
+ +E + L T+ +++++ L+ Q +EK A +Q E Q L+ + E L +
Sbjct: 500 VASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSS 559
Query: 1014 QGEGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEATMELLRVKDRAI-ELERNNAALQAE 1072
+ + T H + A +EA+ LR +D A+ +LE A+
Sbjct: 560 LKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREAS---LRERDAALKQLEALEKEKAAK 616
Query: 1073 KQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQSAAL 1132
++L++QLQ + + + Q++ A L LQ + E +Q A L
Sbjct: 617 LEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAEL 676
Query: 1133 TAQYTLLQNHHTAKETENESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQH 1192
Q Q T KE + + QEQL A E+L G+L E + +AL Q
Sbjct: 677 ELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTK---GSLEEEKRRAADALEEQQ 733
Query: 1193 SCLKTLHRNLELEHKELGERHGDMLKRKAELEEREKVLTTEREALQQE-QRTNALAMGEN 1251
C+ L+ E + L E+H + + ELEE R+ L+ Q+ E
Sbjct: 734 RCIS----ELKAETRSLVEQH---KRERKELEEER----AGRKGLEARLQQLGEAHQAET 782
Query: 1252 QRLRGELDRVNFLHHQLKGEYEELHAHTKELKTSLNNAQLELNRWQARFDELKEQHQTMD 1311
+ LR EL H + E E+L + ++Q E ++ A F E
Sbjct: 783 EVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQE--------- 833
Query: 1312 ISLTKLDNHCELLSRLKGNLEEENHHLL-----SQIQLLSQQNQML-LEQNMENKEQYHE 1365
L L CE + + L+E + S++Q+ QQN++ L N+ Q +
Sbjct: 834 -QLMTLKEECE---KARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQ 889
Query: 1366 EQKQYIDKL-NALRRHKEKLEEKIMDQYKFYDPPPKK-KNHWIGAKALVKLIKPKKEGSR 1423
E++ KL + L +EK+ + + K + ++ LVK +P + G R
Sbjct: 890 EKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVK--EPARAGDR 947
Query: 1424 ERLKSTVDSPPWQLESSDP---ASPAASQPLRSQAENPDTPALGSNCAEERDAHNGSVGK 1480
+ P W E ++ AA Q + +AE +G+ R A S G+
Sbjct: 948 Q--------PEWLEEQQGRQFCSTQAALQAMEREAEQ-----MGNELERLRAALMESQGQ 994
Query: 1481 GPGDLKPKRGSPHRGSLDRTDASTDLAM 1508
+ + R + +R A DLA+
Sbjct: 995 QQEERGQQEREVARLTQERGRAQADLAL 1022
Score = 77.8 bits (190), Expect = 1e-13
Identities = 184/794 (23%), Positives = 320/794 (40%), Gaps = 125/794 (15%)
Query: 184 ELEALSRSMVLHLRRLIDQRDECTELIVDLTQERDYLQAQHPPSPIKSSSADSTPSPTSS 243
ELE L +++ + ++R + + LTQER QA K++ A+ ++
Sbjct: 980 ELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALE--KAARAELEMRLQNA 1037
Query: 244 LSSEDKQHLAVELADTKARLRRVRQELEDKTEQLVDTRHEVDQLVLEL----QKVKQENI 299
L+ + VE A + L E E K ++L R + EL Q VKQ
Sbjct: 1038 LNEQ-----RVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKE 1092
Query: 300 QLA---------ADARSARAYRDELDSLREKANRVERLELELTRCKEKLHDVDFYKARME 350
QLA + A+S A R E + +A R E +LE +C+++ D + +E
Sbjct: 1093 QLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLE-QQCQKQQEQADSLERSLE 1151
Query: 351 ELR----EDNIILIETKAMLEEQLTAARARGDKVHELEKENLQLKSKLHDLELDRDTDKK 406
R E + L + LEE+ + ++E ++K+ D D K
Sbjct: 1152 AERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKA 1211
Query: 407 RIEELLEE-----NMVLEIAQKQSMNESAHLGWELEQLSKNADLSDASRKSFVFE----- 456
++ +E +++ + ++ S+ L E E + S KS E
Sbjct: 1212 QVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRL 1271
Query: 457 LNECASSRILKLEKENQSLQSTIQGLRDASLVLEESGLKCGELEKENHQLSKKIEKLQTQ 516
L +S + + + +L+ +Q LR+ + E+ + L +E +++ E+L +
Sbjct: 1272 LQAETASNSARAAERSSALREEVQSLREEA---EKQRVASENLRQELTSQAERAEELGQE 1328
Query: 517 LE--REK--QSNQDLETLS----------EELIREKEQLQSDMETLKADKARQIKDLEQE 562
L+ +EK Q Q L TL EL+ K Q A + R ++LEQ
Sbjct: 1329 LKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQS 1388
Query: 563 KD-------HLNRAMWSLRE----RSQVSSEARMKDVEKENKA-----------LHQTVT 600
K L RA L E R +V+ + R + KA H +
Sbjct: 1389 KQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLA 1448
Query: 601 EANGKLSQLEFEKRQ-LHRDLEQAKEK------GERAEKLERELQRLQEENGRLARKVTS 653
E N L + RQ L +L+QA+EK RA+ E L +Q E AR++
Sbjct: 1449 EENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADA-ETRLAEVQREAQSTARELEV 1507
Query: 654 LETATE--KVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDN-KQLDAENLELR 710
+ E KV+ LE E Q Q E + L ++ QLE +R+ KQ++ + +L
Sbjct: 1508 MTAKYEGAKVKVLE-ERQRFQEERQKLTAQVE-------QLEVFQREQTKQVEELSKKLA 1559
Query: 711 RLVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLR 770
+ + KL ++ + + ++E + L+ ++ L+A +LS + +AE+ +
Sbjct: 1560 DSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQA--------QLSQKEQAAEHYK 1611
Query: 771 LQQSLESSSHKTQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQL 830
LQ +E +A++Q + E LR LE +K+ K L E +L
Sbjct: 1612 LQ------------MEKAKTHYDAKKQQNQELQEQLR----SLEQLQKENKELRAEAERL 1655
Query: 831 EKD-------KKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAA 883
+ K E+ + L QV +A + + +L + K A D +R A
Sbjct: 1656 GHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSREPQAK 1715
Query: 884 GKLKELEKDNRDLT 897
+L +L D+ DL+
Sbjct: 1716 PQL-DLSIDSLDLS 1728
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 168 bits (426), Expect = 4e-41
Identities = 259/1187 (21%), Positives = 488/1187 (41%), Gaps = 152/1187 (12%)
Query: 286 QLVLELQKVKQENIQLAADARSARAYR-----DELDSLREKANRVERLELELTRCKEKLH 340
Q L KV Q N R+ + +R L + + ++ E EL + KE+
Sbjct: 810 QQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQ 869
Query: 341 DVDFYKARMEELREDNIILIETKAMLEEQLTAARARGDKVHELEKENLQLKSK------- 393
+ ++EL + + L E K +L+EQL +A + E E+ ++L +K
Sbjct: 870 KAE---NELKELEQKHSQLTEEKNLLQEQL---QAETELYAEAEEMRVRLAAKKQELEEI 923
Query: 394 LHDLELDRDTDKKRIEELLEE-----NMVLEIAQKQSMNESAHLGWELEQLSKNADLSDA 448
LH++E + ++ R ++L E +L++ ++ E+A +LE+++ A +
Sbjct: 924 LHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKL 983
Query: 449 SRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASLVLEESGLKCGELEKENHQLSK 508
+ V + + KL KE + L+ I D + L E K L K ++
Sbjct: 984 EDEILVMD------DQNNKLSKERKLLEERIS---DLTTNLAEEEEKAKNLTKLKNKHES 1034
Query: 509 KIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNR 568
I +L+ +L++E++S Q+LE L K +L+ D +D QI DL+ + L
Sbjct: 1035 MISELEVRLKKEEKSRQELEKL-------KRKLEGD----ASDFHEQIADLQAQIAELKM 1083
Query: 569 AMWSLRERSQVSSEARMKDVEKENKALHQTVTEANGKLS----QLEFEKRQLHRDLEQAK 624
+ E Q + ++ ++N AL + + E G +S L+ E+ ++ +Q +
Sbjct: 1084 QLAKKEEELQAALARLDDEIAQKNNAL-KKIRELEGHISDLQEDLDSERAARNKAEKQKR 1142
Query: 625 EKGERAEKLERELQ-------RLQEENGRLARKVTSLETATEKVEALEHESQGLQLENR- 676
+ GE E L+ EL+ QE + ++VT L+ A ++ E HE+Q ++ +
Sbjct: 1143 DLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE-ETRSHEAQVQEMRQKH 1201
Query: 677 --TLRKSLDTLQNVSLQLEGLERDNKQLDAENL----ELRRLVETMRFTSTKLAQMEREN 730
+ + + L+ L+++ + L+ EN ELR L + + K ++E +
Sbjct: 1202 AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQV 1261
Query: 731 QQL-------EREKEELRKNV-----------DLLKALGKKSERLELSYQSVSAENLRLQ 772
Q+L ER + EL V +L K+ +L S+S++ Q
Sbjct: 1262 QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ 1321
Query: 773 QSLESSSHKTQTLESELGELEAERQALRRDLEA-----------LRLANAQLEGAEKDRK 821
+ L+ + + + ++L +LE ER +L+ L+ + N QL ++K +
Sbjct: 1322 ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ 1381
Query: 822 ALEQEVAQLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRD 881
V LE+ KK +KE + L QQ E K A D + +++E L +L R
Sbjct: 1382 DFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQ 1441
Query: 882 AAGKLKE--------LEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQ 933
L++ L ++ +K R RE ++ K+ L+ L++ +
Sbjct: 1442 LVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE----KETKALSLARALEEALE 1497
Query: 934 ELEKVGLNRELLLQEDDSGSDTKYKILEGRNESALKTTLAMKEEKIVLLEAQMEEKASLN 993
E++ ++L E + +K + G+N L E+ LE QMEE +
Sbjct: 1498 AKEELERTNKMLKAEMEDLVSSKDDV--GKNVHEL-------EKSKRALETQMEEMKTQL 1548
Query: 994 RQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEATMELL 1053
+LE ELQ + L N Q L+ F+ Q ++ + L
Sbjct: 1549 EELEDELQATEDAKLRLEVNM---QALKGQFERDL-------QARDEQNEEKRRQLQRQL 1598
Query: 1054 RVKDRAIELERNNAAL-QAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEHNTTLQ 1112
+ +E ER AL A K+ L+ L+ LE Q + ++ A Q Q
Sbjct: 1599 HEYETELEDERKQRALAAAAKKKLEGDLKDLELQ-----ADSAIKGREEAIKQLRKLQAQ 1653
Query: 1113 TQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETENESLQRQQEQLTAAYEALLQDH- 1171
+ + ++E++ S TA+ +N AK E + L + QE L AA A Q
Sbjct: 1654 MKDFQRELEDARASRDEIFATAK----ENEKKAKSLEAD-LMQLQEDLAAAERARKQADL 1708
Query: 1172 ------EHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAELEE 1225
E L + ++A + R + + L LE E + + K + E+
Sbjct: 1709 EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ 1768
Query: 1226 REKVLTTEREALQQEQRTNALAMGENQRLRGELDRV-NFLHHQLKGEYEELHAHTKELKT 1284
L TER Q+ + +N+ LR +L + + + K L A +L+
Sbjct: 1769 LSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLE- 1827
Query: 1285 SLNNAQLELNRWQARFDELKEQHQTMDISLTKLDNHCELLSRLKGNLEEENHHLLSQIQL 1344
+ E QA LK++ + + L ++++ ++ + K E+ N ++++
Sbjct: 1828 --EQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGN----ARVKQ 1881
Query: 1345 LSQQNQMLLEQNME---NKEQYHEEQKQYIDKLNALRRHKEKLEEKI 1388
L +Q + E++ N+ + E + + A+ R L+ K+
Sbjct: 1882 LKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1928
Score = 160 bits (405), Expect = 1e-38
Identities = 251/1079 (23%), Positives = 466/1079 (43%), Gaps = 196/1079 (18%)
Query: 129 GCAVQCERK---EEFIERIKQLDIETQAGIVAHIQEVTHNQENVFDLQWLELPD---VAP 182
G +Q ERK ++ ++ +QL+ E A +++VT + + +L D V
Sbjct: 938 GQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTA------EAKIKKLEDEILVMD 991
Query: 183 EELEALSRSMVLHLRRLIDQRDECTELIVDLTQERDYLQAQHPPSPIKSSSADSTPSPTS 242
++ LS+ R+L+++R ++L +L +E + K+ + +
Sbjct: 992 DQNNKLSKE-----RKLLEER--ISDLTTNLAEEEE-----------KAKNLTKLKNKHE 1033
Query: 243 SLSSEDKQHLAVELADTKARLRRVRQELE----DKTEQLVDTRHEVDQLVLELQKVKQEN 298
S+ SE + L E ++ L +++++LE D EQ+ D + ++ +L ++L K K+E
Sbjct: 1034 SMISELEVRLKKE-EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK-KEEE 1091
Query: 299 IQLAAD------ARSARAYR-------------DELDSLREKANRVER----LELELTRC 335
+Q A A+ A + ++LDS R N+ E+ L EL
Sbjct: 1092 LQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEAL 1151
Query: 336 KEKLHDVDFYKARMEELR--EDNIILIETKAMLEE------QLTAARAR-GDKVHELEKE 386
K +L D A +ELR + + + KA+ EE Q+ R + V EL ++
Sbjct: 1152 KTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQ 1211
Query: 387 NLQLKSKLHDLELDRDTDKKRIEELLEENMVLEIAQKQSMNESAHLGWELEQLSKN---- 442
Q K +L+ ++ T +K +L E VL A+++ ++ L ++++L
Sbjct: 1212 LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG 1271
Query: 443 ----ADLSDASRK------SFVFELNECASSRILKLEKENQSLQSTIQGLRDASLVLEES 492
A+L+D K S LNE A + +KL K+ SL S +Q D +L+E
Sbjct: 1272 ERARAELNDKVHKLQNEVESVTGMLNE-AEGKAIKLAKDVASLSSQLQ---DTQELLQEE 1327
Query: 493 GLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLE----TLSEELIREKEQLQSDMETL 548
+ + + QL ++ LQ QL+ E ++ Q+LE TL+ +L K++LQ T+
Sbjct: 1328 TRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTV 1387
Query: 549 KADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEANGKLSQ 608
+A LE+ K + + +L ++ + + A K +EK L Q + +
Sbjct: 1388 EA--------LEEGKKRFQKEIENLTQQYEEKAAAYDK-LEKTKNRLQQELDD------- 1431
Query: 609 LEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGRLARKVTSLETATEKVEALEHES 668
L DL+ ++ EK +R+ +L E ++ K E + EA E E+
Sbjct: 1432 -------LVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD-ERDRAEAEAREKET 1483
Query: 669 QGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVETMRFTSTKLAQMER 728
+ L L R L ++L+ E LER NK L AE + LV + + ++E+
Sbjct: 1484 KALSLA-RALEEALEAK-------EELERTNKMLKAE---MEDLVSSKDDVGKNVHELEK 1532
Query: 729 ENQQLEREKEELRKNV----DLLKALGKKSERLELSYQSVSAENLR-LQQSLESSSHKTQ 783
+ LE + EE++ + D L+A RLE++ Q++ + R LQ E + K +
Sbjct: 1533 SKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRR 1592
Query: 784 TLESELGELEAERQALRRDLEALRLANAQLEGAEKDR--------KALEQEVAQLEKDKK 835
L+ +L E E E + R+ A +LEG KD K E+ + QL K
Sbjct: 1593 QLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRK--- 1649
Query: 836 LLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRD------AAGKLKEL 889
L+ + K +++E A D+ A EK++++L+ +L + ++ A K +L
Sbjct: 1650 -LQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADL 1708
Query: 890 EKDN--RDLTKQVT-----------VHARTLTTLREDLVLEKLKSQQLSSELDKLSQELE 936
EK+ +L ++ + AR + L E+L E+ + +S + K +Q+ E
Sbjct: 1709 EKEELAEELASSLSGRNALQDEKRRLEAR-IAQLEEELEEEQGNMEAMSDRVRKATQQAE 1767
Query: 937 KVGLNRELL---------------LQEDDSGSDTKYKILEGRNESALKTTLAMKEEKIVL 981
+ L+ EL L+ + +K +EG +S K+T+A E KI
Sbjct: 1768 Q--LSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ 1825
Query: 982 LEAQMEEKASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTAASHQGKEAW 1041
LE Q+E++A + L+ K+ + + + + + +K A K A
Sbjct: 1826 LEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNA-------- 1877
Query: 1042 GPGHKEATMELLRVKDRAIELERNNAALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQ 1100
+ ++K + E E + + A ++ L+ +L N ++ L+ +
Sbjct: 1878 ---------RVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1927
Score = 144 bits (364), Expect = 7e-34
Identities = 247/1144 (21%), Positives = 468/1144 (40%), Gaps = 157/1144 (13%)
Query: 213 LTQERDYLQAQHPPSPIKSSSADSTPSPTSSLSSEDKQHLAVELADTKARLRRVRQELED 272
LT+E++ LQ Q + A+ ++ KQ L L + +ARL +E ED
Sbjct: 885 LTEEKNLLQEQLQAETELYAEAEEMRVRLAA----KKQELEEILHEMEARL----EEEED 936
Query: 273 KTEQLVDTRHEVDQLVLELQKVKQE------NIQLAADARSARAYRDELDSLREKANRVE 326
+ +QL R ++ Q +L+L++ +E +QL A+ + E D + ++
Sbjct: 937 RGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLE-DEILVMDDQNN 995
Query: 327 RLELELTRCKEKLHDVDFYKARMEELREDNIILIETKAMLEEQLTAARARGDKVHELEKE 386
+L E +E++ D+ A EE ++ L + K E ++ R K + +E
Sbjct: 996 KLSKERKLLEERISDLTTNLAEEEEKAKN---LTKLKNKHESMISELEVRLKKEEKSRQE 1052
Query: 387 NLQLKSKLHDLELDRDTDKKRIEELLEE--NMVLEIAQKQSMNESAHLGWELEQLSKNAD 444
+LK K LE D ++I +L + + +++A+K+ ++A + E KN
Sbjct: 1053 LEKLKRK---LEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNN- 1108
Query: 445 LSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASLVLEESGLKCG-ELEKEN 503
A +I +LE LQ + R A E+ G ELE
Sbjct: 1109 ----------------ALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALK 1152
Query: 504 HQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSDMETLKADKARQIKDLEQEK 563
+L ++ TQ E + Q++ L + L E ++ ++ ++ A+ +++L ++
Sbjct: 1153 TELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL 1212
Query: 564 DHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEANGKLSQLEFEKRQLH---RDL 620
+ RA +L ++++ + E D+ E + L Q E K +LE + ++L D
Sbjct: 1213 EQFKRAKANL-DKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG 1271
Query: 621 EQAK-EKGERAEKLERELQ----RLQEENG---RLARKVTSLETATEKVEALEHESQGLQ 672
E+A+ E ++ KL+ E++ L E G +LA+ V SL + + + L E +
Sbjct: 1272 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1331
Query: 673 LENRTLRKSLDTLQN-----VSLQLEGLERDNKQLDAENLELRRLVETMRFTSTKLAQME 727
L T + L+ +N + ++E + + + N++L + ++ ++ + +E
Sbjct: 1332 LNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALE 1391
Query: 728 RENQQLEREKEELRKNVDLLKALGKKSERL------ELSYQSVSAENLR-LQQSLESSSH 780
++ ++E E L + + A K E+ EL V +N R L +LE
Sbjct: 1392 EGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQR 1451
Query: 781 KTQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALE--QEVAQLEKDKKLLE 838
K L +E + + + A RD A+ E EK+ KAL + + + + K+ LE
Sbjct: 1452 KFDQLLAEEKNI-SSKYADERD-------RAEAEAREKETKALSLARALEEALEAKEELE 1503
Query: 839 KEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDNRDLTK 898
+ K L ++E + DD + +EK RAL+ ++ + +L++ + D
Sbjct: 1504 RTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKL 1563
Query: 899 QVTVHARTLT-TLREDLVL----EKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGS 953
++ V+ + L DL + K +QL +L + ELE R L
Sbjct: 1564 RLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKK-L 1622
Query: 954 DTKYKILEGRNESALKTTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLKKECETLRQN 1013
+ K LE + +SA+K +EE I L + R+LE + T ++N
Sbjct: 1623 EGDLKDLELQADSAIKG----REEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKEN 1678
Query: 1014 QGEGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEATMELLRVKDRAIELERNNAALQAEK 1073
+ + + L+ AA+ + + K+A +E + + ALQ EK
Sbjct: 1679 EKKAKSLEADLMQLQEDLAAAERAR-------KQADLEKEELAEELASSLSGRNALQDEK 1731
Query: 1074 QLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQSAALT 1133
+ L+ ++ LE + L+E ++ + +++ S L
Sbjct: 1732 RRLEARIAQLEEE-----------------LEEEQGNMEAMSDRVRKATQQAEQLSNELA 1774
Query: 1134 AQYTLLQNHHTAKETENESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHS 1193
+ + Q + +A+ + L+RQ ++L + LHE + A S
Sbjct: 1775 TERSTAQKNESAR----QQLERQNKELRS-------------KLHEMEGA-------VKS 1810
Query: 1194 CLKTLHRNLELEHKELGERHGDMLKRKAELEEREKVLTTEREALQQEQRTNALAMGENQR 1253
K+ LE + +L E + E E REK T+ + ++ L E++R
Sbjct: 1811 KFKSTIAALEAKIAQLEE--------QVEQEAREKQAATKSLKQKDKKLKEILLQVEDER 1862
Query: 1254 LRGELDRVNFLHHQLKGEYEELHAHTKELKTSLNNAQLELNR-------WQARFDELKEQ 1306
E Q K + E+ +A K+LK L A+ E R Q DE E
Sbjct: 1863 KMAE---------QYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATES 1913
Query: 1307 HQTM 1310
++ M
Sbjct: 1914 NEAM 1917
Score = 134 bits (338), Expect = 7e-31
Identities = 156/662 (23%), Positives = 293/662 (44%), Gaps = 66/662 (9%)
Query: 256 LADTKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSARAYRDEL 315
L + + + ++ +++ + QL DT+ + + + V + QL + S + D+L
Sbjct: 1296 LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ---DQL 1352
Query: 316 DSLREKANRVER----LELELTRCKEKLHDVDFYKARMEELREDNIILIETKAMLEEQLT 371
D E +ER L ++L+ K+KL D + + +E L E + L +Q
Sbjct: 1353 DEEMEAKQNLERHISTLNIQLSDSKKKLQD---FASTVEALEEGKKRFQKEIENLTQQYE 1409
Query: 372 AARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIEELLEENMVLEIAQKQSMNESAH 431
A DK LEK +L+ +L DL +D D ++ + L ++ + + N S+
Sbjct: 1410 EKAAAYDK---LEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSK 1466
Query: 432 LGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASLVLEE 491
E ++ A + S L E ++ +LE+ N+ L++ ++ L + ++
Sbjct: 1467 YADERDRAEAEAREKETKALSLARALEEALEAKE-ELERTNKMLKAEMEDLVSSK---DD 1522
Query: 492 SGLKCGELEKENHQLSKKIEKLQTQLER---EKQSNQD--------LETLSEELIREKEQ 540
G ELEK L ++E+++TQLE E Q+ +D ++ L + R+ +
Sbjct: 1523 VGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQA 1582
Query: 541 LQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVT 600
E + RQ+ + E E + R +L ++ E +KD+E + + +
Sbjct: 1583 RDEQNEEKRRQLQRQLHEYETELED-ERKQRALAAAAKKKLEGDLKDLELQADSAIKGRE 1641
Query: 601 EANGKLSQLEFEKRQLHRDLEQA-----------KEKGERAEKLERELQRLQEE--NGRL 647
EA +L +L+ + + R+LE A KE ++A+ LE +L +LQE+
Sbjct: 1642 EAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAER 1701
Query: 648 ARKVTSLETATEKVEALEHESQG---LQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDA 704
ARK LE E E L G LQ E R L + L+ E LE + ++A
Sbjct: 1702 ARKQADLEKE-ELAEELASSLSGRNALQDEKRRLEARIAQLE------EELEEEQGNMEA 1754
Query: 705 ENLELRRLVETMRFTSTKLA-------QMERENQQLEREKEELRKNVDLLKALGKKSERL 757
+ +R+ + S +LA + E QQLER+ +ELR + ++ G +
Sbjct: 1755 MSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEME--GAVKSKF 1812
Query: 758 ELSYQSVSAENLRLQQSLESSSHKTQTLESELGELEAERQALRRDLEALR-LANAQLEGA 816
+ + ++ A+ +L++ +E + + Q L + + + + + +E R +A E A
Sbjct: 1813 KSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQA 1872
Query: 817 EKDRKALEQEVAQLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKEL 876
EK ++Q QLE+ E+E++R+ LD++T A+ +E AL +L
Sbjct: 1873 EKGNARVKQLKRQLEE----AEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1928
Query: 877 AR 878
R
Sbjct: 1929 RR 1930
Score = 117 bits (294), Expect = 9e-26
Identities = 165/675 (24%), Positives = 301/675 (44%), Gaps = 94/675 (13%)
Query: 159 IQEVTHNQENVFD-LQWLE-----LPDVAPEELEALSRSMVLHLRRLIDQRDECTELIVD 212
+QE T + NV L+ LE L D EE+EA +++ H+ L Q + + + D
Sbjct: 1324 LQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEA-KQNLERHISTLNIQLSDSKKKLQD 1382
Query: 213 LTQERDYLQAQHPPSPIKSSSADSTPSPTSSLSSEDKQHLAVELADTKARLRRVRQELED 272
+ L+ + + E+K +L TK RL+ QEL+D
Sbjct: 1383 FASTVEALE--------EGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ---QELDD 1431
Query: 273 KTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSARA-YRDELDSLREKANRVERLELE 331
L + R QLV L+K +++ QL A+ ++ + Y DE D +A E L
Sbjct: 1432 LVVDLDNQR----QLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALS 1487
Query: 332 LTRCKEKLHDVDFYKARMEELREDNIILIETKAMLEEQLTAARARGDKVHELEKENLQLK 391
L R E+ + EEL N +L KA +E+ +++ G VHELEK L+
Sbjct: 1488 LARALEEALEAK------EELERTNKML---KAEMEDLVSSKDDVGKNVHELEKSKRALE 1538
Query: 392 SKLHDLELDRDTDKKRIEELLEENMVLEIAQ-KQSMNESAHLGWELEQLSKNADLSDASR 450
+++ ++ K ++EEL +E E A+ + +N A G L + ++ R
Sbjct: 1539 TQMEEM-------KTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKR 1591
Query: 451 KSFVFELNECASSRILKLEKENQSLQSTIQGLRDASLVLEESGLKCGELEKENHQLSKKI 510
+ +L+E + L+ E++ ++L + + + L ++ L+ K + K++
Sbjct: 1592 RQLQRQLHEYETE--LEDERKQRALAAAAKKKLEGDL--KDLELQADSAIKGREEAIKQL 1647
Query: 511 EKLQTQLEREKQSNQDLETLSEELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAM 570
KLQ Q++ ++ +D +E+ ++ + ++L+AD + +DL +
Sbjct: 1648 RKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE------- 1700
Query: 571 WSLRERSQVSSEARMKDVEKENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERA 630
R R Q D+EKE A + + +G+ + L+ EKR+L + Q +E+
Sbjct: 1701 ---RARKQA-------DLEKEELA-EELASSLSGR-NALQDEKRRLEARIAQLEEE---- 1744
Query: 631 EKLERELQRLQEENGRLARKVT------SLETATEKVEALEHESQGLQLE--NRTLRKSL 682
LE E ++ + R+ RK T S E ATE+ A ++ES QLE N+ LR L
Sbjct: 1745 --LEEEQGNMEAMSDRV-RKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKL 1801
Query: 683 DTLQNV-----SLQLEGLERD----NKQLDAENLELRRLVETMRFTSTKLA----QMERE 729
++ + LE +Q++ E E + ++++ KL Q+E E
Sbjct: 1802 HEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDE 1861
Query: 730 NQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSSHKTQTLESEL 789
+ E+ KE+ K +K L ++ E E Q ++A +LQ+ L+ ++ + + E+
Sbjct: 1862 RKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREV 1921
Query: 790 GELEAERQALRRDLE 804
L+++ LRR E
Sbjct: 1922 NALKSK---LRRGNE 1933
Score = 109 bits (273), Expect = 2e-23
Identities = 176/811 (21%), Positives = 324/811 (39%), Gaps = 93/811 (11%)
Query: 704 AENLELRRLVETMRFTSTK-LAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQ 762
A L+LR FT K L Q+ R+ ++++ +++EL+K + + + + LE +
Sbjct: 824 AAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHS 883
Query: 763 SVSAENLRLQQSLESSSHKTQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKA 822
++ E LQ+ L++ + E L A++Q L L + + E + +A
Sbjct: 884 QLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQA 943
Query: 823 LEQEVAQ--LEKDKKLLEKEAKRLWQQVE----------LKDAVL--DDSTAKLSAVEKE 868
+++AQ L+ +++L E+EA R Q+E L+D +L DD KLS KE
Sbjct: 944 ERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLS---KE 1000
Query: 869 SRALDKELARCRDAAGKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSEL 928
+ L++ R D L E E+ ++LTK H ++ L L E+ KS+Q EL
Sbjct: 1001 RKLLEE---RISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEE-KSRQ---EL 1053
Query: 929 DKLSQELEKVGLNRELLLQEDDSGSDTKYKILEGRNESA-LKTTLAMKEEKIVLLEAQME 987
+KL ++LE SD +I + + + A LK LA KEE++
Sbjct: 1054 EKLKRKLE-------------GDASDFHEQIADLQAQIAELKMQLAKKEEEL-------- 1092
Query: 988 EKASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGPGHKE 1047
+A+L R L+ E+ + +R+ +G LQ + + K G +
Sbjct: 1093 -QAALAR-LDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1150
Query: 1048 ATMELLRVKDRAIELERNNAALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEH 1107
EL D + A + E +LK+ L+ + + +Q+ ++++ A E
Sbjct: 1151 LKTELEDTLDSTATQQELRAKREQEVTVLKKA---LDEETRSHEAQVQEMRQKHAQAVEE 1207
Query: 1108 NTTLQTQ----TAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETENESLQRQQEQLTAA 1163
T Q A L TL ++A L + +L E + + L+ Q ++L +
Sbjct: 1208 LTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSK 1267
Query: 1164 YEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAEL 1223
ER AE + + L +E L E G +K ++
Sbjct: 1268 CSD-----------GERARAELNDKVHK------LQNEVESVTGMLNEAEGKAIKLAKDV 1310
Query: 1224 EEREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQLKGEYE---ELHAHTK 1280
L +E LQ+E R + + +LR + N L QL E E L H
Sbjct: 1311 ASLSSQLQDTQELLQEETRQK---LNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIS 1367
Query: 1281 ELKTSLNNAQLELNRWQARFDELKEQHQTMDISLTKLDNHCELLSRLKGNLEEENHHLLS 1340
L L++++ +L + + + L+E + + L E + LE+ + L
Sbjct: 1368 TLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQ 1427
Query: 1341 QIQ--LLSQQNQMLLEQNMENKEQYHEE--------QKQYIDKLNALRRHKEKLEEKIMD 1390
++ ++ NQ L N+E K++ ++ +Y D+ + + E K +
Sbjct: 1428 ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALS 1487
Query: 1391 QYKFYDPPPKKKNHWIGAKALVKLIKPKKEGSRERLKSTVDSPPWQLESSDPASPAASQP 1450
+ + + K ++K S++ + V +LE S A +
Sbjct: 1488 LARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVH----ELEKSKRALETQMEE 1543
Query: 1451 LRSQAENPDTPALGSNCAEERDAHNGSVGKG 1481
+++Q E + + A+ R N KG
Sbjct: 1544 MKTQLEELEDELQATEDAKLRLEVNMQALKG 1574
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 168 bits (426), Expect = 4e-41
Identities = 259/1187 (21%), Positives = 488/1187 (41%), Gaps = 152/1187 (12%)
Query: 286 QLVLELQKVKQENIQLAADARSARAYR-----DELDSLREKANRVERLELELTRCKEKLH 340
Q L KV Q N R+ + +R L + + ++ E EL + KE+
Sbjct: 817 QQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQ 876
Query: 341 DVDFYKARMEELREDNIILIETKAMLEEQLTAARARGDKVHELEKENLQLKSK------- 393
+ ++EL + + L E K +L+EQL +A + E E+ ++L +K
Sbjct: 877 KAE---NELKELEQKHSQLTEEKNLLQEQL---QAETELYAEAEEMRVRLAAKKQELEEI 930
Query: 394 LHDLELDRDTDKKRIEELLEE-----NMVLEIAQKQSMNESAHLGWELEQLSKNADLSDA 448
LH++E + ++ R ++L E +L++ ++ E+A +LE+++ A +
Sbjct: 931 LHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKL 990
Query: 449 SRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASLVLEESGLKCGELEKENHQLSK 508
+ V + + KL KE + L+ I D + L E K L K ++
Sbjct: 991 EDEILVMD------DQNNKLSKERKLLEERIS---DLTTNLAEEEEKAKNLTKLKNKHES 1041
Query: 509 KIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNR 568
I +L+ +L++E++S Q+LE L K +L+ D +D QI DL+ + L
Sbjct: 1042 MISELEVRLKKEEKSRQELEKL-------KRKLEGD----ASDFHEQIADLQAQIAELKM 1090
Query: 569 AMWSLRERSQVSSEARMKDVEKENKALHQTVTEANGKLS----QLEFEKRQLHRDLEQAK 624
+ E Q + ++ ++N AL + + E G +S L+ E+ ++ +Q +
Sbjct: 1091 QLAKKEEELQAALARLDDEIAQKNNAL-KKIRELEGHISDLQEDLDSERAARNKAEKQKR 1149
Query: 625 EKGERAEKLERELQ-------RLQEENGRLARKVTSLETATEKVEALEHESQGLQLENR- 676
+ GE E L+ EL+ QE + ++VT L+ A ++ E HE+Q ++ +
Sbjct: 1150 DLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE-ETRSHEAQVQEMRQKH 1208
Query: 677 --TLRKSLDTLQNVSLQLEGLERDNKQLDAENL----ELRRLVETMRFTSTKLAQMEREN 730
+ + + L+ L+++ + L+ EN ELR L + + K ++E +
Sbjct: 1209 AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQV 1268
Query: 731 QQL-------EREKEELRKNV-----------DLLKALGKKSERLELSYQSVSAENLRLQ 772
Q+L ER + EL V +L K+ +L S+S++ Q
Sbjct: 1269 QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ 1328
Query: 773 QSLESSSHKTQTLESELGELEAERQALRRDLEA-----------LRLANAQLEGAEKDRK 821
+ L+ + + + ++L +LE ER +L+ L+ + N QL ++K +
Sbjct: 1329 ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ 1388
Query: 822 ALEQEVAQLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRD 881
V LE+ KK +KE + L QQ E K A D + +++E L +L R
Sbjct: 1389 DFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQ 1448
Query: 882 AAGKLKE--------LEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQ 933
L++ L ++ +K R RE ++ K+ L+ L++ +
Sbjct: 1449 LVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE----KETKALSLARALEEALE 1504
Query: 934 ELEKVGLNRELLLQEDDSGSDTKYKILEGRNESALKTTLAMKEEKIVLLEAQMEEKASLN 993
E++ ++L E + +K + G+N L E+ LE QMEE +
Sbjct: 1505 AKEELERTNKMLKAEMEDLVSSKDDV--GKNVHEL-------EKSKRALETQMEEMKTQL 1555
Query: 994 RQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEATMELL 1053
+LE ELQ + L N Q L+ F+ Q ++ + L
Sbjct: 1556 EELEDELQATEDAKLRLEVNM---QALKGQFERDL-------QARDEQNEEKRRQLQRQL 1605
Query: 1054 RVKDRAIELERNNAAL-QAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEHNTTLQ 1112
+ +E ER AL A K+ L+ L+ LE Q + ++ A Q Q
Sbjct: 1606 HEYETELEDERKQRALAAAAKKKLEGDLKDLELQ-----ADSAIKGREEAIKQLRKLQAQ 1660
Query: 1113 TQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETENESLQRQQEQLTAAYEALLQDH- 1171
+ + ++E++ S TA+ +N AK E + L + QE L AA A Q
Sbjct: 1661 MKDFQRELEDARASRDEIFATAK----ENEKKAKSLEAD-LMQLQEDLAAAERARKQADL 1715
Query: 1172 ------EHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAELEE 1225
E L + ++A + R + + L LE E + + K + E+
Sbjct: 1716 EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ 1775
Query: 1226 REKVLTTEREALQQEQRTNALAMGENQRLRGELDRV-NFLHHQLKGEYEELHAHTKELKT 1284
L TER Q+ + +N+ LR +L + + + K L A +L+
Sbjct: 1776 LSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLE- 1834
Query: 1285 SLNNAQLELNRWQARFDELKEQHQTMDISLTKLDNHCELLSRLKGNLEEENHHLLSQIQL 1344
+ E QA LK++ + + L ++++ ++ + K E+ N ++++
Sbjct: 1835 --EQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGN----ARVKQ 1888
Query: 1345 LSQQNQMLLEQNME---NKEQYHEEQKQYIDKLNALRRHKEKLEEKI 1388
L +Q + E++ N+ + E + + A+ R L+ K+
Sbjct: 1889 LKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1935
Score = 160 bits (405), Expect = 1e-38
Identities = 251/1079 (23%), Positives = 466/1079 (43%), Gaps = 196/1079 (18%)
Query: 129 GCAVQCERK---EEFIERIKQLDIETQAGIVAHIQEVTHNQENVFDLQWLELPD---VAP 182
G +Q ERK ++ ++ +QL+ E A +++VT + + +L D V
Sbjct: 945 GQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTA------EAKIKKLEDEILVMD 998
Query: 183 EELEALSRSMVLHLRRLIDQRDECTELIVDLTQERDYLQAQHPPSPIKSSSADSTPSPTS 242
++ LS+ R+L+++R ++L +L +E + K+ + +
Sbjct: 999 DQNNKLSKE-----RKLLEER--ISDLTTNLAEEEE-----------KAKNLTKLKNKHE 1040
Query: 243 SLSSEDKQHLAVELADTKARLRRVRQELE----DKTEQLVDTRHEVDQLVLELQKVKQEN 298
S+ SE + L E ++ L +++++LE D EQ+ D + ++ +L ++L K K+E
Sbjct: 1041 SMISELEVRLKKE-EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK-KEEE 1098
Query: 299 IQLAAD------ARSARAYR-------------DELDSLREKANRVER----LELELTRC 335
+Q A A+ A + ++LDS R N+ E+ L EL
Sbjct: 1099 LQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEAL 1158
Query: 336 KEKLHDVDFYKARMEELR--EDNIILIETKAMLEE------QLTAARAR-GDKVHELEKE 386
K +L D A +ELR + + + KA+ EE Q+ R + V EL ++
Sbjct: 1159 KTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQ 1218
Query: 387 NLQLKSKLHDLELDRDTDKKRIEELLEENMVLEIAQKQSMNESAHLGWELEQLSKN---- 442
Q K +L+ ++ T +K +L E VL A+++ ++ L ++++L
Sbjct: 1219 LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG 1278
Query: 443 ----ADLSDASRK------SFVFELNECASSRILKLEKENQSLQSTIQGLRDASLVLEES 492
A+L+D K S LNE A + +KL K+ SL S +Q D +L+E
Sbjct: 1279 ERARAELNDKVHKLQNEVESVTGMLNE-AEGKAIKLAKDVASLSSQLQ---DTQELLQEE 1334
Query: 493 GLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLE----TLSEELIREKEQLQSDMETL 548
+ + + QL ++ LQ QL+ E ++ Q+LE TL+ +L K++LQ T+
Sbjct: 1335 TRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTV 1394
Query: 549 KADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEANGKLSQ 608
+A LE+ K + + +L ++ + + A K +EK L Q + +
Sbjct: 1395 EA--------LEEGKKRFQKEIENLTQQYEEKAAAYDK-LEKTKNRLQQELDD------- 1438
Query: 609 LEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGRLARKVTSLETATEKVEALEHES 668
L DL+ ++ EK +R+ +L E ++ K E + EA E E+
Sbjct: 1439 -------LVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD-ERDRAEAEAREKET 1490
Query: 669 QGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVETMRFTSTKLAQMER 728
+ L L R L ++L+ E LER NK L AE + LV + + ++E+
Sbjct: 1491 KALSLA-RALEEALEAK-------EELERTNKMLKAE---MEDLVSSKDDVGKNVHELEK 1539
Query: 729 ENQQLEREKEELRKNV----DLLKALGKKSERLELSYQSVSAENLR-LQQSLESSSHKTQ 783
+ LE + EE++ + D L+A RLE++ Q++ + R LQ E + K +
Sbjct: 1540 SKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRR 1599
Query: 784 TLESELGELEAERQALRRDLEALRLANAQLEGAEKDR--------KALEQEVAQLEKDKK 835
L+ +L E E E + R+ A +LEG KD K E+ + QL K
Sbjct: 1600 QLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRK--- 1656
Query: 836 LLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRD------AAGKLKEL 889
L+ + K +++E A D+ A EK++++L+ +L + ++ A K +L
Sbjct: 1657 -LQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADL 1715
Query: 890 EKDN--RDLTKQVT-----------VHARTLTTLREDLVLEKLKSQQLSSELDKLSQELE 936
EK+ +L ++ + AR + L E+L E+ + +S + K +Q+ E
Sbjct: 1716 EKEELAEELASSLSGRNALQDEKRRLEAR-IAQLEEELEEEQGNMEAMSDRVRKATQQAE 1774
Query: 937 KVGLNRELL---------------LQEDDSGSDTKYKILEGRNESALKTTLAMKEEKIVL 981
+ L+ EL L+ + +K +EG +S K+T+A E KI
Sbjct: 1775 Q--LSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ 1832
Query: 982 LEAQMEEKASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTAASHQGKEAW 1041
LE Q+E++A + L+ K+ + + + + + +K A K A
Sbjct: 1833 LEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNA-------- 1884
Query: 1042 GPGHKEATMELLRVKDRAIELERNNAALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQ 1100
+ ++K + E E + + A ++ L+ +L N ++ L+ +
Sbjct: 1885 ---------RVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1934
Score = 144 bits (364), Expect = 7e-34
Identities = 247/1144 (21%), Positives = 468/1144 (40%), Gaps = 157/1144 (13%)
Query: 213 LTQERDYLQAQHPPSPIKSSSADSTPSPTSSLSSEDKQHLAVELADTKARLRRVRQELED 272
LT+E++ LQ Q + A+ ++ KQ L L + +ARL +E ED
Sbjct: 892 LTEEKNLLQEQLQAETELYAEAEEMRVRLAA----KKQELEEILHEMEARL----EEEED 943
Query: 273 KTEQLVDTRHEVDQLVLELQKVKQE------NIQLAADARSARAYRDELDSLREKANRVE 326
+ +QL R ++ Q +L+L++ +E +QL A+ + E D + ++
Sbjct: 944 RGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLE-DEILVMDDQNN 1002
Query: 327 RLELELTRCKEKLHDVDFYKARMEELREDNIILIETKAMLEEQLTAARARGDKVHELEKE 386
+L E +E++ D+ A EE ++ L + K E ++ R K + +E
Sbjct: 1003 KLSKERKLLEERISDLTTNLAEEEEKAKN---LTKLKNKHESMISELEVRLKKEEKSRQE 1059
Query: 387 NLQLKSKLHDLELDRDTDKKRIEELLEE--NMVLEIAQKQSMNESAHLGWELEQLSKNAD 444
+LK K LE D ++I +L + + +++A+K+ ++A + E KN
Sbjct: 1060 LEKLKRK---LEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNN- 1115
Query: 445 LSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASLVLEESGLKCG-ELEKEN 503
A +I +LE LQ + R A E+ G ELE
Sbjct: 1116 ----------------ALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALK 1159
Query: 504 HQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSDMETLKADKARQIKDLEQEK 563
+L ++ TQ E + Q++ L + L E ++ ++ ++ A+ +++L ++
Sbjct: 1160 TELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL 1219
Query: 564 DHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEANGKLSQLEFEKRQLH---RDL 620
+ RA +L ++++ + E D+ E + L Q E K +LE + ++L D
Sbjct: 1220 EQFKRAKANL-DKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG 1278
Query: 621 EQAK-EKGERAEKLERELQ----RLQEENG---RLARKVTSLETATEKVEALEHESQGLQ 672
E+A+ E ++ KL+ E++ L E G +LA+ V SL + + + L E +
Sbjct: 1279 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1338
Query: 673 LENRTLRKSLDTLQN-----VSLQLEGLERDNKQLDAENLELRRLVETMRFTSTKLAQME 727
L T + L+ +N + ++E + + + N++L + ++ ++ + +E
Sbjct: 1339 LNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALE 1398
Query: 728 RENQQLEREKEELRKNVDLLKALGKKSERL------ELSYQSVSAENLR-LQQSLESSSH 780
++ ++E E L + + A K E+ EL V +N R L +LE
Sbjct: 1399 EGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQR 1458
Query: 781 KTQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALE--QEVAQLEKDKKLLE 838
K L +E + + + A RD A+ E EK+ KAL + + + + K+ LE
Sbjct: 1459 KFDQLLAEEKNI-SSKYADERD-------RAEAEAREKETKALSLARALEEALEAKEELE 1510
Query: 839 KEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDNRDLTK 898
+ K L ++E + DD + +EK RAL+ ++ + +L++ + D
Sbjct: 1511 RTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKL 1570
Query: 899 QVTVHARTLT-TLREDLVL----EKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGS 953
++ V+ + L DL + K +QL +L + ELE R L
Sbjct: 1571 RLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKK-L 1629
Query: 954 DTKYKILEGRNESALKTTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLKKECETLRQN 1013
+ K LE + +SA+K +EE I L + R+LE + T ++N
Sbjct: 1630 EGDLKDLELQADSAIKG----REEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKEN 1685
Query: 1014 QGEGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEATMELLRVKDRAIELERNNAALQAEK 1073
+ + + L+ AA+ + + K+A +E + + ALQ EK
Sbjct: 1686 EKKAKSLEADLMQLQEDLAAAERAR-------KQADLEKEELAEELASSLSGRNALQDEK 1738
Query: 1074 QLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQSAALT 1133
+ L+ ++ LE + L+E ++ + +++ S L
Sbjct: 1739 RRLEARIAQLEEE-----------------LEEEQGNMEAMSDRVRKATQQAEQLSNELA 1781
Query: 1134 AQYTLLQNHHTAKETENESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHS 1193
+ + Q + +A+ + L+RQ ++L + LHE + A S
Sbjct: 1782 TERSTAQKNESAR----QQLERQNKELRS-------------KLHEMEGA-------VKS 1817
Query: 1194 CLKTLHRNLELEHKELGERHGDMLKRKAELEEREKVLTTEREALQQEQRTNALAMGENQR 1253
K+ LE + +L E + E E REK T+ + ++ L E++R
Sbjct: 1818 KFKSTIAALEAKIAQLEE--------QVEQEAREKQAATKSLKQKDKKLKEILLQVEDER 1869
Query: 1254 LRGELDRVNFLHHQLKGEYEELHAHTKELKTSLNNAQLELNR-------WQARFDELKEQ 1306
E Q K + E+ +A K+LK L A+ E R Q DE E
Sbjct: 1870 KMAE---------QYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATES 1920
Query: 1307 HQTM 1310
++ M
Sbjct: 1921 NEAM 1924
Score = 134 bits (338), Expect = 7e-31
Identities = 156/662 (23%), Positives = 293/662 (44%), Gaps = 66/662 (9%)
Query: 256 LADTKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSARAYRDEL 315
L + + + ++ +++ + QL DT+ + + + V + QL + S + D+L
Sbjct: 1303 LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ---DQL 1359
Query: 316 DSLREKANRVER----LELELTRCKEKLHDVDFYKARMEELREDNIILIETKAMLEEQLT 371
D E +ER L ++L+ K+KL D + + +E L E + L +Q
Sbjct: 1360 DEEMEAKQNLERHISTLNIQLSDSKKKLQD---FASTVEALEEGKKRFQKEIENLTQQYE 1416
Query: 372 AARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIEELLEENMVLEIAQKQSMNESAH 431
A DK LEK +L+ +L DL +D D ++ + L ++ + + N S+
Sbjct: 1417 EKAAAYDK---LEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSK 1473
Query: 432 LGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASLVLEE 491
E ++ A + S L E ++ +LE+ N+ L++ ++ L + ++
Sbjct: 1474 YADERDRAEAEAREKETKALSLARALEEALEAKE-ELERTNKMLKAEMEDLVSSK---DD 1529
Query: 492 SGLKCGELEKENHQLSKKIEKLQTQLER---EKQSNQD--------LETLSEELIREKEQ 540
G ELEK L ++E+++TQLE E Q+ +D ++ L + R+ +
Sbjct: 1530 VGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQA 1589
Query: 541 LQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVT 600
E + RQ+ + E E + R +L ++ E +KD+E + + +
Sbjct: 1590 RDEQNEEKRRQLQRQLHEYETELED-ERKQRALAAAAKKKLEGDLKDLELQADSAIKGRE 1648
Query: 601 EANGKLSQLEFEKRQLHRDLEQA-----------KEKGERAEKLERELQRLQEE--NGRL 647
EA +L +L+ + + R+LE A KE ++A+ LE +L +LQE+
Sbjct: 1649 EAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAER 1708
Query: 648 ARKVTSLETATEKVEALEHESQG---LQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDA 704
ARK LE E E L G LQ E R L + L+ E LE + ++A
Sbjct: 1709 ARKQADLEKE-ELAEELASSLSGRNALQDEKRRLEARIAQLE------EELEEEQGNMEA 1761
Query: 705 ENLELRRLVETMRFTSTKLA-------QMERENQQLEREKEELRKNVDLLKALGKKSERL 757
+ +R+ + S +LA + E QQLER+ +ELR + ++ G +
Sbjct: 1762 MSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEME--GAVKSKF 1819
Query: 758 ELSYQSVSAENLRLQQSLESSSHKTQTLESELGELEAERQALRRDLEALR-LANAQLEGA 816
+ + ++ A+ +L++ +E + + Q L + + + + + +E R +A E A
Sbjct: 1820 KSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQA 1879
Query: 817 EKDRKALEQEVAQLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKEL 876
EK ++Q QLE+ E+E++R+ LD++T A+ +E AL +L
Sbjct: 1880 EKGNARVKQLKRQLEE----AEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1935
Query: 877 AR 878
R
Sbjct: 1936 RR 1937
Score = 117 bits (294), Expect = 9e-26
Identities = 165/675 (24%), Positives = 301/675 (44%), Gaps = 94/675 (13%)
Query: 159 IQEVTHNQENVFD-LQWLE-----LPDVAPEELEALSRSMVLHLRRLIDQRDECTELIVD 212
+QE T + NV L+ LE L D EE+EA +++ H+ L Q + + + D
Sbjct: 1331 LQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEA-KQNLERHISTLNIQLSDSKKKLQD 1389
Query: 213 LTQERDYLQAQHPPSPIKSSSADSTPSPTSSLSSEDKQHLAVELADTKARLRRVRQELED 272
+ L+ + + E+K +L TK RL+ QEL+D
Sbjct: 1390 FASTVEALE--------EGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ---QELDD 1438
Query: 273 KTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSARA-YRDELDSLREKANRVERLELE 331
L + R QLV L+K +++ QL A+ ++ + Y DE D +A E L
Sbjct: 1439 LVVDLDNQR----QLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALS 1494
Query: 332 LTRCKEKLHDVDFYKARMEELREDNIILIETKAMLEEQLTAARARGDKVHELEKENLQLK 391
L R E+ + EEL N +L KA +E+ +++ G VHELEK L+
Sbjct: 1495 LARALEEALEAK------EELERTNKML---KAEMEDLVSSKDDVGKNVHELEKSKRALE 1545
Query: 392 SKLHDLELDRDTDKKRIEELLEENMVLEIAQ-KQSMNESAHLGWELEQLSKNADLSDASR 450
+++ ++ K ++EEL +E E A+ + +N A G L + ++ R
Sbjct: 1546 TQMEEM-------KTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKR 1598
Query: 451 KSFVFELNECASSRILKLEKENQSLQSTIQGLRDASLVLEESGLKCGELEKENHQLSKKI 510
+ +L+E + L+ E++ ++L + + + L ++ L+ K + K++
Sbjct: 1599 RQLQRQLHEYETE--LEDERKQRALAAAAKKKLEGDL--KDLELQADSAIKGREEAIKQL 1654
Query: 511 EKLQTQLEREKQSNQDLETLSEELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAM 570
KLQ Q++ ++ +D +E+ ++ + ++L+AD + +DL +
Sbjct: 1655 RKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE------- 1707
Query: 571 WSLRERSQVSSEARMKDVEKENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERA 630
R R Q D+EKE A + + +G+ + L+ EKR+L + Q +E+
Sbjct: 1708 ---RARKQA-------DLEKEELA-EELASSLSGR-NALQDEKRRLEARIAQLEEE---- 1751
Query: 631 EKLERELQRLQEENGRLARKVT------SLETATEKVEALEHESQGLQLE--NRTLRKSL 682
LE E ++ + R+ RK T S E ATE+ A ++ES QLE N+ LR L
Sbjct: 1752 --LEEEQGNMEAMSDRV-RKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKL 1808
Query: 683 DTLQNV-----SLQLEGLERD----NKQLDAENLELRRLVETMRFTSTKLA----QMERE 729
++ + LE +Q++ E E + ++++ KL Q+E E
Sbjct: 1809 HEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDE 1868
Query: 730 NQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSSHKTQTLESEL 789
+ E+ KE+ K +K L ++ E E Q ++A +LQ+ L+ ++ + + E+
Sbjct: 1869 RKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREV 1928
Query: 790 GELEAERQALRRDLE 804
L+++ LRR E
Sbjct: 1929 NALKSK---LRRGNE 1940
Score = 109 bits (273), Expect = 2e-23
Identities = 176/811 (21%), Positives = 324/811 (39%), Gaps = 93/811 (11%)
Query: 704 AENLELRRLVETMRFTSTK-LAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQ 762
A L+LR FT K L Q+ R+ ++++ +++EL+K + + + + LE +
Sbjct: 831 AAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHS 890
Query: 763 SVSAENLRLQQSLESSSHKTQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKA 822
++ E LQ+ L++ + E L A++Q L L + + E + +A
Sbjct: 891 QLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQA 950
Query: 823 LEQEVAQ--LEKDKKLLEKEAKRLWQQVE----------LKDAVL--DDSTAKLSAVEKE 868
+++AQ L+ +++L E+EA R Q+E L+D +L DD KLS KE
Sbjct: 951 ERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLS---KE 1007
Query: 869 SRALDKELARCRDAAGKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSEL 928
+ L++ R D L E E+ ++LTK H ++ L L E+ KS+Q EL
Sbjct: 1008 RKLLEE---RISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEE-KSRQ---EL 1060
Query: 929 DKLSQELEKVGLNRELLLQEDDSGSDTKYKILEGRNESA-LKTTLAMKEEKIVLLEAQME 987
+KL ++LE SD +I + + + A LK LA KEE++
Sbjct: 1061 EKLKRKLE-------------GDASDFHEQIADLQAQIAELKMQLAKKEEEL-------- 1099
Query: 988 EKASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGPGHKE 1047
+A+L R L+ E+ + +R+ +G LQ + + K G +
Sbjct: 1100 -QAALAR-LDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1157
Query: 1048 ATMELLRVKDRAIELERNNAALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEH 1107
EL D + A + E +LK+ L+ + + +Q+ ++++ A E
Sbjct: 1158 LKTELEDTLDSTATQQELRAKREQEVTVLKKA---LDEETRSHEAQVQEMRQKHAQAVEE 1214
Query: 1108 NTTLQTQ----TAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETENESLQRQQEQLTAA 1163
T Q A L TL ++A L + +L E + + L+ Q ++L +
Sbjct: 1215 LTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSK 1274
Query: 1164 YEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAEL 1223
ER AE + + L +E L E G +K ++
Sbjct: 1275 CSD-----------GERARAELNDKVHK------LQNEVESVTGMLNEAEGKAIKLAKDV 1317
Query: 1224 EEREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQLKGEYE---ELHAHTK 1280
L +E LQ+E R + + +LR + N L QL E E L H
Sbjct: 1318 ASLSSQLQDTQELLQEETRQK---LNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIS 1374
Query: 1281 ELKTSLNNAQLELNRWQARFDELKEQHQTMDISLTKLDNHCELLSRLKGNLEEENHHLLS 1340
L L++++ +L + + + L+E + + L E + LE+ + L
Sbjct: 1375 TLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQ 1434
Query: 1341 QIQ--LLSQQNQMLLEQNMENKEQYHEE--------QKQYIDKLNALRRHKEKLEEKIMD 1390
++ ++ NQ L N+E K++ ++ +Y D+ + + E K +
Sbjct: 1435 ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALS 1494
Query: 1391 QYKFYDPPPKKKNHWIGAKALVKLIKPKKEGSRERLKSTVDSPPWQLESSDPASPAASQP 1450
+ + + K ++K S++ + V +LE S A +
Sbjct: 1495 LARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVH----ELEKSKRALETQMEE 1550
Query: 1451 LRSQAENPDTPALGSNCAEERDAHNGSVGKG 1481
+++Q E + + A+ R N KG
Sbjct: 1551 MKTQLEELEDELQATEDAKLRLEVNMQALKG 1581
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 168 bits (426), Expect = 4e-41
Identities = 270/1246 (21%), Positives = 537/1246 (43%), Gaps = 186/1246 (14%)
Query: 248 DKQHLAVELADTKARLRRVRQELEDKTEQLVDTRHEVDQLVL----ELQKVKQENIQLAA 303
D + +A++ A LR EL++K ++L T +++ + +L+ K+ + L
Sbjct: 629 DAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEK 688
Query: 304 DARSARAYRDELDSL---REKANRVERLELE--LTRCKEKLH-DVDFYKARMEELREDNI 357
+ +SA +L SL + + + LELE +T +++L+ +V+ E LRE+ I
Sbjct: 689 ELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVE----ENEALREEVI 744
Query: 358 ILIETKAMLEEQLTAARARGDKVHELEKENLQLKSKLHDLELDRDT-------DKKRIEE 410
+L E K++ E V L KE +LH + ++D + R++
Sbjct: 745 LLSELKSLPSE-----------VERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQG 793
Query: 411 LLEE----------------------------NMVLEIAQKQSMNESAHLGWELEQLSKN 442
LLEE +M E K + E+ + E+ LSK
Sbjct: 794 LLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKE 853
Query: 443 ADLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASLVLEESGLKCGELEKE 502
A D+S + EL S + +L+++ + +Q + + LE +E+E
Sbjct: 854 AQKFDSSLGALKTEL----SYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVERE 909
Query: 503 NHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSDMETLKADKARQIKDLEQE 562
+++K+++ +++ Q DL+ L E L E++QL+SD+ D D +++
Sbjct: 910 KTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIH----DTVNMNIDTQEQ 965
Query: 563 KDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEANGKLSQLEFEKRQLHRDLEQ 622
L A+ SL++ + + + K E+ ++ LH E N ++ EF+++ + D +Q
Sbjct: 966 ---LRNALESLKQHQETINTLKSKISEEVSRNLHM---EENTGETKDEFQQKMVGIDKKQ 1019
Query: 623 -----------AKEKGERAEKLERELQRLQEENGRLARKVTSLETATEKVEALEHESQGL 671
A K + +R++ L +E L + + S+ E+++ E+ +
Sbjct: 1020 DLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEM 1079
Query: 672 QLENRTLRKSLDTLQNVSLQLEGLERDN--KQLDAENLELRRLVETMRFTSTKLAQMERE 729
+EN+ + L ++ E+++ K+ + RL E K Q++ +
Sbjct: 1080 TIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEK 1139
Query: 730 NQQL---EREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSSHKTQTLE 786
QQL + E E++K ++ ++ L + + EL+ + + E L L Q L + + +++
Sbjct: 1140 QQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSIT 1199
Query: 787 SE---LGEL----EAERQALR---RDLEA--------LRLANAQL----EGAEKDRKALE 824
E L EL E ER LR R++EA L++A+ L E ++ R+++
Sbjct: 1200 KERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVS 1259
Query: 825 QEVAQ------LEKDKKLLEKEAKRLWQQVELKDAVLD-----DSTAKLSAVEKESRALD 873
++ AQ LEK L++E L ++ EL V + ++ +L + ++S D
Sbjct: 1260 EKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKD 1319
Query: 874 K-ELARCRDAAGKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLS 932
LAR +L E +++++ K +T L T++E L ++K QL + +
Sbjct: 1320 STTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEAL---EVKHDQLKEHIRETL 1376
Query: 933 QELEKVGLNRELLLQEDDSGSDTKYKILEGRNESALKTTLAMKEEKIVLLEAQMEEKASL 992
++++ +E L + ++T + E K+ ++ +E +M +
Sbjct: 1377 AKIQESQSKQEQSLNMKEKDNETTKIVSE-------MEQFKPKDSALLRIEIEMLGLSKR 1429
Query: 993 NRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTAASH-QGKEAWGPGH-----K 1046
++ E++ + KE + L++ Q Q + K + A H + +E H +
Sbjct: 1430 LQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQ 1489
Query: 1047 EATMELLRV--KDRAIELERNNAALQAEKQLLKEQLQHLETQNVTFS-SQILTLQKQSAF 1103
E T+ LRV ++ E+ L+A L+ ++Q + + F+ QI +Q++
Sbjct: 1490 EETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNE 1549
Query: 1104 LQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETENESLQRQQEQLTAA 1163
L++ + + + LQ ++ S+ LT + Q E E ++R QE L
Sbjct: 1550 LKQFKEHRKAKDSALQ----SIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIE 1605
Query: 1164 YEALLQD-HEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEH-KELGERHGDMLKRKA 1221
+ L ++ E + + E Q EY+ ++ + +T + E+EH KE E +K
Sbjct: 1606 RDQLKENTKEIVAKMKESQEKEYQ-FLKMTAVNETQEKMCEIEHLKEQFE------TQKL 1658
Query: 1222 ELEEREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQLKGEYEELHAHTKE 1281
LE E TE L Q N + E + + E D + + LK E ++L + +E
Sbjct: 1659 NLENIE----TENIRLTQILHEN---LEEMRSVTKERDDLRSVEETLKVERDQLKENLRE 1711
Query: 1282 LKTSLNNAQLELNRWQARFDELKEQHQTMDISLTKLDNHCELLSRLKGNLEEENHHLLSQ 1341
+ R + +ELK H L H E + +L+G + E+ + + +
Sbjct: 1712 ----------TITRDLEKQEELKIVHM-------HLKEHQETIDKLRGIVSEKTNEISNM 1754
Query: 1342 IQLLSQQNQMLLEQNMENKEQ------YHEEQKQYIDKLNALRRHK 1381
+ L N L Q+++ +E+ + +EQ++ IDKL + K
Sbjct: 1755 QKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEK 1800
Score = 152 bits (385), Expect = 2e-36
Identities = 275/1433 (19%), Positives = 593/1433 (41%), Gaps = 183/1433 (12%)
Query: 52 LQIDPRPTNQRINKHVNNDVNLRIQNLTI-LVRNIKTYYQEVLQQLI------------V 98
LQ R +R+N+ L ++ T+ V KT E LQQ + +
Sbjct: 875 LQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDL 934
Query: 99 MNLPNVLMIGRDPLSGKSMEEIKKVLLLVLGCAVQCERKEEFIERIKQLD--IETQAGIV 156
L L I RD L + + + E ++ E I L I +
Sbjct: 935 KQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRN 994
Query: 157 AHIQEVTHNQENVFDLQWLELPDVAPEELEALSRSMV---LHLRRLIDQRDECTELIVDL 213
H++E T ++ F + + + ++LEA + + + +I+Q+ + I L
Sbjct: 995 LHMEENTGETKDEFQQKMVGIDK--KQDLEAKNTQTLTADVKDNEIIEQQRK----IFSL 1048
Query: 214 TQERDYLQAQHPPSPIKSSSADSTPSPTSSLSSEDKQHLAVELADTKARLRRVRQELEDK 273
QE++ LQ + + ++ E+++ L + + K + V QE
Sbjct: 1049 IQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHA 1108
Query: 274 TEQLVDTRHEVDQLVLELQKVKQENIQLAADARSARAYRDELDSLREKANRVERLELELT 333
++ + D+L +K+K+++ QL + ++E+ +++K N +E L+ EL
Sbjct: 1109 IKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELK 1168
Query: 334 RCKEKLHDVDFYKARMEELREDNIILIETKAMLEEQLTAARARGDKVHELEKENLQLKSK 393
+ L ++ + + + +N ++V + KE LK
Sbjct: 1169 NKELTLEHMETERLELAQKLNENY--------------------EEVKSITKERKVLKEL 1208
Query: 394 LHDLELDRDTDKKRIEELLEENMVLEIAQKQSMNESAHLGWELEQLSKNADLSDASRKSF 453
E +RD + I E+ + Q + + AH+ L ++ + D R+S
Sbjct: 1209 QKSFETERDHLRGYIREIEATGL-----QTKEELKIAHI-----HLKEHQETIDELRRSV 1258
Query: 454 VFELNECASSRILKLEKENQSLQSTIQGLRDASLVL------EESGLKCGELEKENHQLS 507
+ + +++ LEK + LQ I L + +L E+ ELE Q +
Sbjct: 1259 SEKTAQIINTQ--DLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQST 1316
Query: 508 KKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSDMETLKADKARQIKDLEQEKDHLN 567
K ++E E+ + S+E I+ + + +++T+K +A ++K +Q K+H+
Sbjct: 1317 TKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIK--EALEVKH-DQLKEHIR 1373
Query: 568 RAMWSLRERSQVSSEARMKDVEKENKALH-----QTVTEANGKLSQLEFEKRQLHRDLEQ 622
+ ++E SQ E + EK+N+ + + L ++E E L + L++
Sbjct: 1374 ETLAKIQE-SQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQE 1432
Query: 623 AKEKGERAEKLERELQRLQEENGRLARKVTSLETATEKVEALEHES-QGLQLENRTLRKS 681
+ ++ + K + +LQRLQE L + L+ +++ A E+ + L++ + L++
Sbjct: 1433 SHDEMKSVAKEKDDLQRLQEV---LQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQ 1489
Query: 682 LDTLQNVSLQLEGLERD----NKQLDAENLELRRLVETMRFTSTKLAQMERENQQLEREK 737
+T+ + + L E + KQL+A N +L+ ++ + E+E Q ++
Sbjct: 1490 EETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEI---------YEKEEQFNIKQI 1540
Query: 738 EELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSSHKTQTLESELGELEAERQ 797
E+++ V+ LK + + + + QS+ ++ L L L+ S + Q + E E++ ++
Sbjct: 1541 SEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQE 1600
Query: 798 ALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEK--EAKRLWQQVELKDAVL 855
AL+ + + L+ ++ K+ + E + ++ + EK E + L +Q E + L
Sbjct: 1601 ALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNL 1660
Query: 856 DD---STAKLSAVEKESRALDKELARCRDAAGKLKELEKDNRDLTKQVTVHARTLTTLRE 912
++ +L+ + E+ + + + RD ++E K RD K+ LRE
Sbjct: 1661 ENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKE---------NLRE 1711
Query: 913 DLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSDTKYKILEGRNESALKTTL 972
+ + K ++L L + E + R ++ ++ + S+ + K LE N++ L
Sbjct: 1712 TITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQ-KDLEHSNDALKAQDL 1770
Query: 973 AMKEEKIV-----------------LLEAQMEEKASLNRQLESELQMLKKECETLRQNQG 1015
++EE + ++ + ++ +++ + LE+ L+++ + L+ N+
Sbjct: 1771 KIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEH 1830
Query: 1016 EGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEATMELLRVKD--------------RAIE 1061
+ L+ K + Q K+ + T+ L +++ +++
Sbjct: 1831 QLITLKKDVNETQKKVSEMEQLKKQ--IKDQSLTLSKLEIENLNLAQKLHENLEEMKSVM 1888
Query: 1062 LERNN-----AALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEHNTTLQTQTA 1116
ER+N L+ E+ LKE LQ + +++ ++ T + S +EH T+
Sbjct: 1889 KERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLS---KEHKETVDKLRE 1945
Query: 1117 KLQVENSTLSSQSAALTAQYTLLQNHHTAKETENESLQRQQEQLTAAYEALLQDHEHLGT 1176
K+ + +S L LQ + + L R +E + +++ + + E L
Sbjct: 1946 KISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKK-INEMEQLKK 2004
Query: 1177 LHERQSAEYEAL-IRQHSCLKTLHRNLELEHKELGERHGDMLKRKAELE-EREKVLTTER 1234
E Q+ +++ + K LH +LE E + + + ++ + K L+ ER++ + T R
Sbjct: 2005 QFEAQNLSMQSVRMDNFQLTKKLHESLE-EIRIVAKERDELRRIKESLKMERDQFIATLR 2063
Query: 1235 EALQQEQRTNALAMGENQRLRGELDRVNFLHHQLKGEYEELHAHTKELKTSLNNAQLELN 1294
E + ++++ +HQ+K E L + L SL +
Sbjct: 2064 EMIARDRQ----------------------NHQVKPEKRLLSDGQQHLTESLREKCSRIK 2101
Query: 1295 RWQARFDELKEQHQTMD-ISL---TKLDNHCELLSRLKGNLEEENHHLLSQIQLLSQQNQ 1350
R+ E+ + ++ ++ +SL +++ EL R+K N LS L ++ +
Sbjct: 2102 ELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKAN--------LSLPYLQTKHIE 2153
Query: 1351 MLLEQNMENKEQYHEEQKQYIDKLNALRRHKEKLEEKIMD-QYKFYDPPPKKK 1402
L N ++H K+ L+ + + KE+ E I + F D K+K
Sbjct: 2154 KLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQK 2206
Score = 149 bits (377), Expect = 2e-35
Identities = 280/1318 (21%), Positives = 573/1318 (43%), Gaps = 215/1318 (16%)
Query: 246 SEDKQHLAVELADTKARLRRVRQELEDKTEQLVDTRHEVDQL------------------ 287
S++ Q L K L QEL++KT ++ + +E++QL
Sbjct: 851 SKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREK 910
Query: 288 ----------VLELQKVKQENIQLAADARSARAYRDEL-----DSLREKANRVERLELEL 332
+ E++ + QE L S + RD+L D++ + E+L L
Sbjct: 911 TLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNAL 970
Query: 333 TRCKEKLHDVDFYKARMEELREDNIILIETKAMLEEQLTAARARGDKVHELEKENLQ-LK 391
K+ ++ K+++ E N+ + E +++ DK +LE +N Q L
Sbjct: 971 ESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLT 1030
Query: 392 SKLHDLELDRDTDK--KRIEELLEENMVLE--IAQKQSMNESAHLGWEL----------- 436
+ + D E+ K I+E E +LE IA+K+ + E+
Sbjct: 1031 ADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLL 1090
Query: 437 -EQLSKNADLSDASRKSFVFELNECASS--RIL----KLEKENQSLQSTIQGLRDASLVL 489
++L K ++ + + + E + + R+ KL++++Q LQ Q L + +
Sbjct: 1091 GDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEM 1150
Query: 490 EESGLKCGELEKENHQLSKK---IEKLQTQ-LEREKQSNQDLETLSEELIREK---EQLQ 542
E K E+E ++L K +E ++T+ LE ++ N++ E + + + +E+ ++LQ
Sbjct: 1151 SEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEV-KSITKERKVLKELQ 1209
Query: 543 SDMETLKADKARQIKDLE----QEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALH-Q 597
ET + I+++E Q K+ L A L+E + E R EK + ++ Q
Sbjct: 1210 KSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQ 1269
Query: 598 TVTEANGKLSQ---LEFEKRQLHRDLEQAKEKGERAEKLER----------------ELQ 638
+ +++ KL + + E+++L ++++ E E +LE E++
Sbjct: 1270 DLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEME 1329
Query: 639 RL---------QEENGRLARKVTSLETATEKVEALEHESQGLQLENRTLRKSLDTLQNVS 689
RL QEE L ++ +L+T E +E ++H+ Q + TL K ++
Sbjct: 1330 RLRLNEKFQESQEEIKSLTKERDNLKTIKEALE-VKHD-QLKEHIRETLAKIQESQSKQE 1387
Query: 690 LQLEGLERDN---------KQLDAENLELRRLVETMRFTSTKLAQMERENQQLEREKEEL 740
L E+DN +Q ++ L R+ M S +L + E + + +EK++L
Sbjct: 1388 QSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDL 1447
Query: 741 RKNVDLLKALGKKSERLELSYQSVSAENLRLQQS-------LESSSHKTQTLESELGELE 793
++ L + L +S++L+ + + + A++L ++ L+ L L E E
Sbjct: 1448 QR---LQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKE 1504
Query: 794 AERQALRRDLEAL--RLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQQVELK 851
E +++ LEA+ +L N E EK+ + ++++++++ E K+ + + K
Sbjct: 1505 TEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEK----VNELKQFKEHRKAK 1560
Query: 852 DAVLDDSTAKLSAVE---KESRALDKELARCRDAAGKLKELEKDNRDLTKQVT--VHART 906
D+ L +K+ + +ES+ + + + ++ +++E + RD K+ T + A+
Sbjct: 1561 DSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKM 1620
Query: 907 LTTLREDLVLEKL----KSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSDTKYKILEG 962
+ ++ K+ ++Q+ E++ L ++ E LN E + E+ + ++ LE
Sbjct: 1621 KESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEE 1680
Query: 963 -RNESALKTTLAMKEEKIVLLEAQMEE--KASLNRQLESELQM------LKKECETLRQN 1013
R+ + + L EE + + Q++E + ++ R LE + ++ LK+ ET+ +
Sbjct: 1681 MRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKL 1740
Query: 1014 QG-------EGQHLQNSFKHPAGKTAASH-QGKEAWGPGH-----KEATMELLR--VKDR 1058
+G E ++Q +H A + +E H ++ T++ LR V ++
Sbjct: 1741 RGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEK 1800
Query: 1059 AIELERNNAALQAEKQLLKEQLQHL---ETQNVTFSSQILTLQKQSAFLQEHNTTLQTQT 1115
+L L+ L+E++Q L E Q +T + QK+ + +++ ++ Q+
Sbjct: 1801 TDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQS 1860
Query: 1116 ---AKLQVENSTLSSQSAALTAQYTLLQNHHTAKETENESLQRQQEQLTAAYEALLQDHE 1172
+KL++EN L+ Q H E E +S+ ++++ L E L + +
Sbjct: 1861 LTLSKLEIENLNLA-------------QKLHENLE-EMKSVMKERDNLRRVEETLKLERD 1906
Query: 1173 HL-GTLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKA-ELEEREKVL 1230
L +L E ++ + E I+Q LKT R L EHKE ++ + + K ++ + +K L
Sbjct: 1907 QLKESLQETKARDLE--IQQE--LKTA-RMLSKEHKETVDKLREKISEKTIQISDIQKDL 1961
Query: 1231 TTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQLKGEYEELHAHTKELKTSLNNAQ 1290
++ LQ ++ L E Q LR + D VN H ++ E E+L + S+ + +
Sbjct: 1962 DKSKDELQ--KKIQELQKKELQLLRVKED-VNMSHKKI-NEMEQLKKQFEAQNLSMQSVR 2017
Query: 1291 LELNRWQARFDELKEQHQTMDISLTKLDNHCELLSRLKGNL-----------------EE 1333
++ F K+ H++++ + + + L R+K +L +
Sbjct: 2018 MD------NFQLTKKLHESLE-EIRIVAKERDELRRIKESLKMERDQFIATLREMIARDR 2070
Query: 1334 ENHHLLSQIQLLSQQNQMLLEQNMENKEQYHEEQKQYI---DKLNALRRHKEKLEEKI 1388
+NH + + +LLS Q L E E + E K+Y D L R LE++I
Sbjct: 2071 QNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEI 2128
Score = 144 bits (362), Expect = 1e-33
Identities = 270/1261 (21%), Positives = 545/1261 (43%), Gaps = 165/1261 (13%)
Query: 255 ELADTKARLRRVRQELEDKTEQL----VDTR---HEVDQL--VLE----LQKV---KQEN 298
E++ +A L+R R+E+ D +QL ++TR E DQL +LE LQKV K EN
Sbjct: 337 EVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIEN 396
Query: 299 IQLAADARSARAYRDELDSLREKANRVERLELELTRCKEKLHDVDF----------YKAR 348
+ S+ + EL + R++ RV ++ + K + F +K
Sbjct: 397 LTRMLVTSSSLTLQQELKAKRKR--RVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLS 454
Query: 349 MEELRE-DNIILIETKAMLEEQLTAARARGDKVHE-LEKENLQLKSKLHDLELDRDTDKK 406
+ LRE D + E+ T + + + L +EN++ S+L+ L D D
Sbjct: 455 INLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIE--SELNSLRADYDNLVL 512
Query: 407 RIEELL--EENMVLEIAQKQSMNESAHL------GWELEQLSKNADLSDASRKSFVFEL- 457
E+L +E M L++ +K ++E L E++ + + ++L + + + V+
Sbjct: 513 DYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQD 572
Query: 458 --NECASSRILKLEKENQ--SLQSTIQGLRDASLVLEES-GLKCGELEKENHQLSKKIEK 512
NE +S L EKE+Q LQ I + ++ ++ S L+ E K+ Q E
Sbjct: 573 LENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAET 632
Query: 513 LQTQLERE----KQSNQDLETLSEELIREKEQLQSDME----TLKADKARQIKDLEQEKD 564
+ +RE + N +L+ +EL +Q+++D++ L+A K Q+ DLE+E
Sbjct: 633 VALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQV-DLEKELQ 691
Query: 565 HLNRAMWSLRE----------RSQVSSEARMKDVEK-------ENKALHQTVTEANGKLS 607
+ L + E ++ D++K EN+AL + V + +L
Sbjct: 692 SAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLS-ELK 750
Query: 608 QLEFEKRQLHRDLEQAKEK----GERAEKL-------ERELQRLQEENGRLARKVTSLET 656
L E +L ++++ E+ +KL E +Q L EE G+ L T
Sbjct: 751 SLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTK---DDLAT 807
Query: 657 ATEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVETM 716
++ + E Q +TL +D Q + LE ER N+++ + E ++ ++
Sbjct: 808 TQSNYKSTDQEFQNF----KTLH--MDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSL 861
Query: 717 RFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLE 776
T+L+ +E Q+ RE +E ++ LK ++ E + + Q+V E + + L+
Sbjct: 862 GALKTELSYKTQELQEKTREVQERLNEMEQLK---EQLENRDSTLQTVEREKTLITEKLQ 918
Query: 777 SSSHKTQTLESELGELEAERQALRRDLEALR-----LANAQLEGAEKDRKALE---QEVA 828
+ + +TL E +L+ +++L+ + + L+ N ++ E+ R ALE Q
Sbjct: 919 QTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQE 978
Query: 829 QLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKE 888
+ K + +E R E D+ K+ ++K+ + L+ + + A K E
Sbjct: 979 TINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKK-QDLEAKNTQTLTADVKDNE 1037
Query: 889 LEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQE 948
+ + R + + L + E ++ EK +QL ++ L + +E N+E L
Sbjct: 1038 IIEQQRKIFSLIQ-EKNELQQMLESVIAEK---EQLKTD---LKENIEMTIENQEELRLL 1090
Query: 949 DDSGSDTKYKILEGRNESALKT-TLAMKEEKIVLLEAQMEEKASLNRQLESELQMLKKEC 1007
D + + + +N + K L+ +++ +E +++EK+ ++ + +L +++E
Sbjct: 1091 GDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEM 1150
Query: 1008 ETLRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGPGHK--EATMELLRVKDRAIELERN 1065
+++ E ++L+N K+ + H E K E E+ + L+
Sbjct: 1151 SEMQKKINEIENLKNELKNK--ELTLEHMETERLELAQKLNENYEEVKSITKERKVLKEL 1208
Query: 1066 NAALQAEKQLLKEQLQHLETQNVTFSSQI----LTLQKQSAFLQEHNTTLQTQTAK---- 1117
+ + E+ L+ ++ +E + ++ + L++ + E ++ +TA+
Sbjct: 1209 QKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINT 1268
Query: 1118 --LQVENSTLSSQSAALTAQYTLLQNHHTAKETEN--ESLQRQQEQLTAAYEALL----Q 1169
L+ ++ L + L + LL N ET+ L+ EQ T L
Sbjct: 1269 QDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEM 1328
Query: 1170 DHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGERHGDML--------KRKA 1221
+ L + E ++L ++ LKT+ LE++H +L E + L K++
Sbjct: 1329 ERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQ 1388
Query: 1222 ELEEREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQLKGEYEELHAHTKE 1281
L +EK T + + EQ ++ LR E++ + L +L+ ++E+ + KE
Sbjct: 1389 SLNMKEKDNETTKIVSEMEQ----FKPKDSALLRIEIEMLG-LSKRLQESHDEMKSVAKE 1443
Query: 1282 LKTSLNNAQLELNRWQARFDELKEQ-----------HQTMDISLTKLDNHCELLSRLKGN 1330
K L Q L Q+ D+LKE + + ++ L E ++ L+ N
Sbjct: 1444 -KDDLQRLQEVL---QSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVN 1499
Query: 1331 LEEENHHLLS---QIQLLSQQNQMLLEQNMENKEQYHEEQ-KQYIDKLNALRRHKEKLEE 1386
L E+ + + Q++ ++ + Q +++ E +EQ++ +Q + +K+N L++ KE +
Sbjct: 1500 LSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKA 1559
Query: 1387 K 1387
K
Sbjct: 1560 K 1560
Score = 140 bits (353), Expect = 1e-32
Identities = 272/1327 (20%), Positives = 554/1327 (41%), Gaps = 221/1327 (16%)
Query: 133 QCERKEEFIERIKQLDIETQAGI-VAHI----QEVTHNQENVFDLQWLELPDVAPEELEA 187
+ ++ +E I+ I +ET+ + VAH QE T N+ V + ++LEA
Sbjct: 1457 ESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEA 1516
Query: 188 LSRSMVLHLRRL--------IDQRDECTELIVDLTQERDYLQAQHPPSPIKSSSADSTPS 239
++ + ++ + I Q E E + +L Q +++ +A K S+ S S
Sbjct: 1517 INDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKA-------KDSALQSIES 1569
Query: 240 PTSSLSS---EDKQHLAVELADTKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQKVKQ 296
L++ E ++ + + + + K ++RV++ L+ + +QL + E+ + E Q+ +
Sbjct: 1570 KMLELTNRLQESQEEIQIMIKE-KEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEY 1628
Query: 297 ENIQLAADARSARAYRDELDSLREKANRVERLELELTRCKEKLHDVDFYKARMEELREDN 356
+ +++ A ++ +EK +E L+ + K L +++ R+ ++ +N
Sbjct: 1629 QFLKMTA-----------VNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHEN 1677
Query: 357 IILIETKAMLEEQLTAARARGD--KVHE-LEKENLQLKSKLHDL---ELDRDTDKKRIEE 410
LEE + + R D V E L+ E QLK L + +L++ + K +
Sbjct: 1678 ---------LEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHM 1728
Query: 411 LLEENMVLEIAQKQSMNESAHLGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEK 470
L+E+ + ++E + E+ + K+ + S+ + K+ ++ E RI +
Sbjct: 1729 HLKEHQETIDKLRGIVSEKTN---EISNMQKDLEHSNDALKAQDLKIQE--ELRIAHMHL 1783
Query: 471 ENQSLQSTIQGLRDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETL 530
+ Q Q TI LR ++ E K ++K+ L KLQ +++ K + L TL
Sbjct: 1784 KEQ--QETIDKLRG---IVSEKTDKLSNMQKD---LENSNAKLQEKIQELKANEHQLITL 1835
Query: 531 SEELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEK 590
++ + E ++ S+ME LK +QIKD L +L ++ + E MK V K
Sbjct: 1836 KKD-VNETQKKVSEMEQLK----KQIKDQSLTLSKLEIENLNLAQKLHENLE-EMKSVMK 1889
Query: 591 ENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGRLARK 650
E L + L+ E+ QL L++ K + + E+Q+
Sbjct: 1890 ERDNLRRVE-------ETLKLERDQLKESLQETKAR-------DLEIQQ----------- 1924
Query: 651 VTSLETATEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELR 710
E T ++ + EH+ T+ K + + ++Q+ +++D LD EL+
Sbjct: 1925 ----ELKTARMLSKEHKE--------TVDKLREKISEKTIQISDIQKD---LDKSKDELQ 1969
Query: 711 RLVETMRFTSTKLAQMERENQQLEREKEELR---KNVDLLKALGKKSERLELSYQSVSAE 767
+ K+ +++++ QL R KE++ K ++ ++ L K+ E LS QSV +
Sbjct: 1970 K----------KIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMD 2019
Query: 768 NLRLQQSLESSSHKTQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEV 827
N +L + L S E+ + ER LRR E+L++ Q ++ A +++
Sbjct: 2020 NFQLTKKLHESLE-------EIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQN 2072
Query: 828 AQLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDK---ELARCRDAAG 884
Q++ +K+LL + L + + K + + + + S ++ L++ +L + +
Sbjct: 2073 HQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQK 2132
Query: 885 KLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNREL 944
+L K N L T H L T +Q+ S E ++ ++L+ V L+
Sbjct: 2133 ELSMRVKANLSLPYLQTKHIEKLFT----------ANQRCSMEFHRIMKKLKYV-LSYVT 2181
Query: 945 LLQEDDSGSDTKYKILEGRNESALKTTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLK 1004
++E+ S K++ + ++++K +L++ Q L+ + +
Sbjct: 2182 KIKEEQHESINKFE---------MDFIDEVEKQKELLIKIQ---------HLQQDCDVPS 2223
Query: 1005 KECETLRQNQGEGQHLQNSFKHPAGKTAASHQGK-EAWGPGHKEATMELLRVKDRAIELE 1063
+E L+ NQ H++ K + S + + + KE T L + ++E
Sbjct: 2224 RELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIE 2283
Query: 1064 RNNAALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEHNTTL----QTQTAKLQ 1119
+ +Q E + + N F+++I+ + +S +E + T+ + L+
Sbjct: 2284 KLKNGIQKENDRICQ-------VNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLK 2336
Query: 1120 VENSTLSSQSAAL-TAQYTLLQNHHTAKETENESLQRQQEQLTAAYEALLQDHEHLGTLH 1178
+N L L T+ + Q + T ++ +N + + QLT L++ +LH
Sbjct: 2337 EKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELEN-----SLH 2391
Query: 1179 ERQSAEYEALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAELEEREKVLTTEREALQ 1238
E A+ A+ ++ +K KEL + + K +A++ E K L +E +Q
Sbjct: 2392 E---AKESAMHKESKIIKM--------QKELEVTNDIIAKLQAKVHESNKCLEKTKETIQ 2440
Query: 1239 QEQRTNALA----MGENQRLRGELDRVNFLHHQLKGEYEELHAHTKELKTSLNNAQLELN 1294
Q AL E + L+ +L +++ + E+E KE+ + + +
Sbjct: 2441 VLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFE------KEISATKATVEYQKE 2494
Query: 1295 RWQARFDELKEQHQTMDISLTKLDNHCE---------------LLSRLKG-NLEEENHHL 1338
+ + L+ Q D S+ + H + ++ K L+ E+ L
Sbjct: 2495 VIRLLRENLRRSQQAQDTSV--ISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRL 2552
Query: 1339 LSQIQLLSQQNQMLLEQNME---NKEQYHEEQKQYIDKLNALRRHKEKLEEKIMDQYKFY 1395
+I L QQN+ L++Q E N + E K + ++ HK+ E K
Sbjct: 2553 EKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLKREAHKQVTCENSPKSPKVT 2612
Query: 1396 DPPPKKK 1402
KKK
Sbjct: 2613 GTASKKK 2619
Score = 133 bits (334), Expect = 2e-30
Identities = 223/1079 (20%), Positives = 455/1079 (42%), Gaps = 129/1079 (11%)
Query: 385 KENLQLKSKLHDLELD---RDTDKKRIEELLEENMVLEIAQKQSMNESAHLGWELEQLSK 441
KE + LK +L ++ L+ + +K ++ +LLEE +L+ Q + + + L+
Sbjct: 350 KEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTL 409
Query: 442 NADLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASLVLEESGLKCGELEK 501
+L ++ + L +I K++ N + Q I ++ + L L +
Sbjct: 410 QQELKAKRKRRVTWCLG-----KINKMKNSNYADQFNIP----TNITTKTHKLSINLLRE 460
Query: 502 ENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSDMETLKADKARQIKDLEQ 561
+ + + + L+ + ++E + +E ++S++ +L+AD + D EQ
Sbjct: 461 IDESVCSESDVFSNTLD----TLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQ 516
Query: 562 ---EKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEANGKLSQLEFEKRQLHR 618
EK+ + + + + + R ++E + +H+ ++ + E + L
Sbjct: 517 LRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHE-ISNLKNLVKHAEVYNQDLEN 575
Query: 619 DL----EQAKEKGERAEKLER--ELQRLQEENGRLARKVTSLETATEKVEAL-------- 664
+L E +EK ++ +KL+ + Q+L+ L+ + S+E + + L
Sbjct: 576 ELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVAL 635
Query: 665 --EHESQGLQLENRTLRKSLDTLQNVSLQLEG--------LERDNK-QLDAENLELRRLV 713
+ ES L+ EN L++ + L Q+E LE K Q+D E
Sbjct: 636 DAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFN 695
Query: 714 ETMRFTSTKLAQMERE---NQQLERE----KEELRKNVDLLKALGKKSERLELS-YQSVS 765
E + TS ++ ++ N +LE + ++EL K V+ +AL + E + LS +S+
Sbjct: 696 EITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEAL--REEVILLSELKSLP 753
Query: 766 AENLRLQQSLESSSHKTQTLESELGELEAE----RQALRRDLEALRLANAQLEGAEKDRK 821
+E RL++ ++ S + + SE +L +E ++ LE + L + + K
Sbjct: 754 SEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYK 813
Query: 822 ALEQEV-------AQLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDK 874
+ +QE E+ K++ +E +R+ Q++ + L A++ E +
Sbjct: 814 STDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQ 873
Query: 875 EL-ARCRDAAGKLKELEK-----DNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSEL 928
EL + R+ +L E+E+ +NRD T Q +TL T + LE++K+ L+ E
Sbjct: 874 ELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKT--LTQEK 931
Query: 929 DKLSQELEKVGLNRELLLQEDDSGSDTKYKILEGRNESALKTTLAMKEEKIVLLEAQMEE 988
D L Q E + + R+ L + + E + +AL+ +L +E I L++++ E
Sbjct: 932 DDLKQLQESLQIERDQLKSDIHDTVNMNIDTQE-QLRNALE-SLKQHQETINTLKSKISE 989
Query: 989 KASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEA 1048
+ S N +E K E + + Q L+ ++ E +
Sbjct: 990 EVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIE-----QQRK 1044
Query: 1049 TMELLRVKDRAIELERNNAALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEHN 1108
L++ K+ EL++ ++ AEK+ LK L+ +N+ +T++ Q +
Sbjct: 1045 IFSLIQEKN---ELQQMLESVIAEKEQLKTDLK----ENIE-----MTIENQEELRLLGD 1092
Query: 1109 TTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETENESLQRQQEQLTAAYEALL 1168
+ Q Q +N + + L + KE +++ LQ +Q+QL E
Sbjct: 1093 ELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKE-KSQQLQEKQQQLLNVQE--- 1148
Query: 1169 QDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAELEEREK 1228
+ +E + I + LK +N EL + + ++ ++ E E K
Sbjct: 1149 ------------EMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVK 1196
Query: 1229 VLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQLKGEYEELHAHTKELKTSLNN 1288
+T ER+ L++ Q++ E LRG + + Q K E + H H KE + +++
Sbjct: 1197 SITKERKVLKELQKSFET---ERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDE 1253
Query: 1289 AQLELNRWQARF---DELKEQHQTMDISLTKLDNHCELLSRLKGNLEEENHHLLSQIQLL 1345
+ ++ A+ +L++ H + + L ELL +K E +++++LL
Sbjct: 1254 LRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKE--VSETQETMNELELL 1311
Query: 1346 SQQN-----------QMLLEQNMENKEQYHEEQKQYIDKLNALRRHKEKLEEKIMDQYK 1393
++Q+ +M + E ++ EE K + + L+ KE LE K DQ K
Sbjct: 1312 TEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVK-HDQLK 1369
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 168 bits (426), Expect = 4e-41
Identities = 277/1208 (22%), Positives = 494/1208 (40%), Gaps = 127/1208 (10%)
Query: 252 LAVELAD--TKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSAR 309
+A+E A +A L+ R +KT QL + E V +L++ + Q A+A AR
Sbjct: 1565 VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1624
Query: 310 AYRD-ELDSLREKANRVERLELELTRCKEKLHDVDFYKARMEELREDNIILIETKAMLEE 368
+ EL+ + KAN RL L+ +E +A E+ +E+ + EE
Sbjct: 1625 EEAERELERWQLKANEALRLRLQ---AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEE 1681
Query: 369 QLTAARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIEELLEENMVLEIAQKQSMNE 428
Q A R R ELEK+ +L T ++R+ +E + L +Q +
Sbjct: 1682 Q--AVRQRELAEQELEKQR----------QLAEGTAQQRLAAE-QELIRLRAETEQGEQQ 1728
Query: 429 SAHLGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASLV 488
L EL +L + A + R+ EL + + + L + ++ + + +
Sbjct: 1729 RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1788
Query: 489 LEESGLKCGELEKENHQLSKKIE--KLQTQLEREKQSNQDLETLSEELIREKEQLQSDME 546
LE + EL +E +L E K Q QL E + Q E +E ++ EK +
Sbjct: 1789 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE--AERVLAEKLAAIGEAT 1846
Query: 547 TLKADKARQIKDLEQEKDHLNRAMWS---LRERSQVSSEARMKDVEKE----NKALHQTV 599
LK + +K+ E E + L R R R + + D+E+ KA +
Sbjct: 1847 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1906
Query: 600 TEANGKLSQLEFEKRQLHRDLEQAKEKGERAE----KLERELQRLQE--ENGRLARKVTS 653
G + ++RQ+ ++ K E+A +LE EL R++ E+ +++
Sbjct: 1907 ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 1966
Query: 654 LETATEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLV 713
LE A ++ A E E + + E R ++KSL + + Q + + ++L A+ E RRL
Sbjct: 1967 LEAARQRQLAAEEERRRREAEER-VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLR 2025
Query: 714 ETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQ 773
E S + Q+ +E Q + EE A+ +K + L+ + Q + +L+
Sbjct: 2026 ERAEQESARQLQLAQEAAQKRLQAEEKAHAF----AVQQKEQELQQTLQQEQSVLDQLRG 2081
Query: 774 SLESSSHKTQTLESELGELEAERQAL--RRDLEALRLANAQLEGAEKDRKALEQEVAQLE 831
E++ + E+E ++AER+A RR +E A + AE+ +A Q A E
Sbjct: 2082 EAEAARRAAE--EAEEARVQAEREAAQSRRQVEE---AERLKQSAEEQAQARAQAQAAAE 2136
Query: 832 KDKKLLEKEAKRLWQ-------QVELKDAVLDDSTAKLSAVEKESRALDKELARCR---- 880
K +K E+EA R Q Q + DA ++ ++ +++EL R
Sbjct: 2137 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2196
Query: 881 DAAGKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGL 940
+ + L+++ + L + T AR + + E+L +++ ++LS ++ E
Sbjct: 2197 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE------ 2250
Query: 941 NRELLLQEDDSGS----DTKYKILEGRNESALKTTLAMK--------EEKIVLLEAQMEE 988
NR L+L++ D+ + K+ + E+A + A + EE + A E+
Sbjct: 2251 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEK 2310
Query: 989 KASLNRQLESELQMLKKECETLRQN----QGEGQHLQNSFKHPAGKTAASHQG----KEA 1040
Q E LK E E L+Q Q + + LQ + A + A QG EA
Sbjct: 2311 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2370
Query: 1041 WGPGHKEATMELLRVKDRAIELERNNAALQAEKQLLKEQLQH---------LETQNVTFS 1091
E + E R+K R E+ R A + + Q ++Q + L TQ
Sbjct: 2371 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2430
Query: 1092 SQILTLQKQSAF-----LQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAK 1146
Q L +Q+Q + L+E L+ + KLQ E L +S + +Q +
Sbjct: 2431 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQT----VQQEQLLQ 2486
Query: 1147 ETE--NESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLEL 1204
ET+ +S +++ L + Q+ L L + + A+ + L + + + +E
Sbjct: 2487 ETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ---QRQQQQMEQ 2543
Query: 1205 EHKELGERHGDMLKRKAELEEREKVLTTEREALQQEQRTNA-LAMGENQRLRGELDRVNF 1263
E + L + +R+ E EE + E + L+Q++R L ENQRLR +L +
Sbjct: 2544 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEE 2603
Query: 1264 LHHQLKGEYEELHAHTKELKTSLNNAQLELNRWQAR------FDELKEQHQTMDISLTKL 1317
H EE+ A +L N + L+ A FD L+ + + +
Sbjct: 2604 QHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGI 2663
Query: 1318 DNHCELLSRLKGNL--------EEENHHLLSQIQLLSQQNQMLLEQNMENKEQYHEEQKQ 1369
+ EL +G+ E+ H+L + + +LL+ E Y Q+Q
Sbjct: 2664 LSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAG----LLLKATNEKLSVYAALQRQ 2719
Query: 1370 YIDKLNAL 1377
+ AL
Sbjct: 2720 LLSPGTAL 2727
Score = 158 bits (399), Expect = 6e-38
Identities = 294/1385 (21%), Positives = 558/1385 (40%), Gaps = 161/1385 (11%)
Query: 176 ELPDVAPEELEALSRSMVLHLRRLIDQRD--ECTELIVDLTQERDYLQAQHPPSPIKSSS 233
EL D+ + LEA V LR +D+ EC + I + Q++ + + + S
Sbjct: 988 ELKDIRLQ-LEACETRTVHRLRLPLDKEPARECAQRIAE--QQKAQAEVEGLGKGVARLS 1044
Query: 234 ADSTPSPTSSLSSEDKQHLAVELADTKARLRRVR-----------------------QEL 270
A++ S L EL T +L +VR +E+
Sbjct: 1045 AEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEV 1104
Query: 271 EDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSAR----AYRDELDSLREKANRVE 326
E+ + V + EL+ K +L A A + + A RDEL +E R++
Sbjct: 1105 LRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQ 1164
Query: 327 RL----ELELTRCKEK-----------LHDVDFYKARMEELREDNIILIETKAMLEEQLT 371
+ ++E+ R +E+ L D + +E+L E+ L L
Sbjct: 1165 QRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQ 1224
Query: 372 AARARGDKVHELEKENLQ-LKSKLHDLELDRDTDKKRIEELLEENMVLEIAQ---KQSMN 427
AR R +++ + + Q ++ +L ++ +EE+ +E Q KQ +N
Sbjct: 1225 DARRRQEQIQAMPLADSQAVREQLRQ-------EQALLEEIERHGEKVEECQRFAKQYIN 1277
Query: 428 ESAHLGWELEQLSKNADL---SDASRKSFVFELNECASSRILKLEKENQSLQS-TIQGLR 483
A +EL+ ++ A L + ++K V +E + L L + T Q ++
Sbjct: 1278 --AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK 1335
Query: 484 DASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQS 543
S L + E++ + +++ +++ LE+++Q + + RE ++LQ
Sbjct: 1336 FISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1395
Query: 544 DMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKA--------- 594
M+ + D +Q+K + + LR+ S+ +A+ + E ++
Sbjct: 1396 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1455
Query: 595 ---LHQTVTE-----ANGKLSQLEFEKRQLHRDLEQAKEKGERAEK-LERELQRLQEENG 645
L TE A G+L L + QA+E+ ER + ++ E QR ++
Sbjct: 1456 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1515
Query: 646 RLARKV-TSLETATEKVEAL----EHESQGLQLENRTLRKSLDTLQNVSLQLEGLERD-- 698
LA +V E A EK AL E Q + E R + ++ + V + LE +R
Sbjct: 1516 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1575
Query: 699 -----------------NKQLDAENLELRRLVETMRFTSTKLAQMERENQQLEREKE--E 739
+ L E++ + +L E + + A+ ER ++ ERE E +
Sbjct: 1576 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1635
Query: 740 LRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLES----SSHKTQTLESELGELEAE 795
L+ N L L + + S AE + + E+ + + + EL E E E
Sbjct: 1636 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1695
Query: 796 R----------QALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLW 845
+ Q L + E +RL A+ E E+ R+ LE+E+A+L+++ ++ + L
Sbjct: 1696 KQRQLAEGTAQQRLAAEQELIRL-RAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1754
Query: 846 QQVELKDAVLDDSTAKLSAVEKESRAL-DKELARCRDAAGKLKELEKDNRDLTKQVTVHA 904
++ A ++ A + E+ESR+ +K R AG+ +EL ++ L
Sbjct: 1755 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1814
Query: 905 RTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSDTKYKILEGRN 964
R ED ++ +++++ +E E ++ E+ L+E ++ ++ ++ E +
Sbjct: 1815 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE--D 1872
Query: 965 ESALKTTLAMKEEKIVLLEAQMEEK-ASLNRQLESELQMLKKECE-TLRQN---QGEGQH 1019
E+ + L EE+ +A +EE+ A L + +SEL+ K E TLRQ + E
Sbjct: 1873 EAFQRRRL---EEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA 1929
Query: 1020 LQNSF-KHPAGKTAAS------HQGKEAWGPGHKEATMELLRVKDRAIELE--RNNAALQ 1070
L+ SF K AGK E ++A +E R + A E E R A +
Sbjct: 1930 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 1989
Query: 1071 AEKQLLKEQLQHLETQNVTFSSQILTLQKQSA----FLQEHNTTLQTQTAKLQVENSTLS 1126
+K L E+ + + + L + + A E + Q Q A+ + +
Sbjct: 1990 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2049
Query: 1127 SQSAALTAQYTLLQNHHTAKETENESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYE 1186
+ A A Q + E L + + + AA A ++ E ER++A+
Sbjct: 2050 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA-AEEAEEARVQAEREAAQSR 2108
Query: 1187 ALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAELEEREKVLTTEREALQQEQRTNAL 1246
+ + LK + + + + + L+++AE +E + E+ AL+Q+Q +A
Sbjct: 2109 RQVEEAERLKQSAEE-QAQARAQAQAAAEKLRKEAE-QEAARRAQAEQAALRQKQAADA- 2165
Query: 1247 AMGENQRLRGELDRVNFLHHQLKGEYEELHAHTKELKTSLNNAQLELNRWQARFDELKEQ 1306
E ++ + ++ Q++ E L +E N EL R +A E Q
Sbjct: 2166 ---EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2222
Query: 1307 HQTMDISLTKLDNHCELLSRLKGNLEEENHHLLSQIQLLSQQNQMLLEQNMENKEQYHEE 1366
++ L + E LS+LK +E EN L+ + + Q L++ E +Q EE
Sbjct: 2223 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK---DNTQRFLQEEAEKMKQVAEE 2279
Query: 1367 QKQYIDKLNALRRHKEKLEEKIMDQYKFYDPPPKKKNHWI----GAKALVKLIKPKKEGS 1422
+ R ++ EE + Q + K+K + KA +L++ +KE +
Sbjct: 2280 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA 2339
Query: 1423 RERLK 1427
+E+ +
Sbjct: 2340 QEQAR 2344
Score = 119 bits (299), Expect = 2e-26
Identities = 167/790 (21%), Positives = 355/790 (44%), Gaps = 131/790 (16%)
Query: 249 KQHLAVELADTKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSA 308
++ A AD + RL ++R+ + + E+ + V+ + + ++V++E + L A A
Sbjct: 1881 EEQAAQHKADIEERLAQLRKASDSELER---QKGLVEDTLRQRRQVEEEILALKASFEKA 1937
Query: 309 RAYRDEL------------DSLREKANRVERLELELTRCKEKLHDVDFYKARMEELREDN 356
A + EL D+LR K E+ ELE R ++ + + + EE + +
Sbjct: 1938 AAGKAELELELGRIRSNAEDTLRSK----EQAELEAARQRQLAAEEERRRREAEERVQKS 1993
Query: 357 IILIET-----KAMLEEQLTAARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIE-- 409
+ E KA LEE + +A+ ++ L + Q ++ L+L ++ +KR++
Sbjct: 1994 LAAEEEAARQRKAALEE-VERLKAKVEEARRLRERAEQESAR--QLQLAQEAAQKRLQAE 2050
Query: 410 --------ELLEENMVLEIAQKQSMNESAHLGWELEQLSKNADLSDASRKSFVFELNECA 461
+ E+ + + Q+QS+ + L E E + A+ ++ +R V E A
Sbjct: 2051 EKAHAFAVQQKEQELQQTLQQEQSVLDQ--LRGEAEAARRAAEEAEEAR---VQAEREAA 2105
Query: 462 SSR--ILKLEKENQSLQSTIQGLRDASLVLEESGLKCGELEKENHQ-LSKKIEKLQTQLE 518
SR + + E+ QS + Q A E+ L KE Q +++ + Q L
Sbjct: 2106 QSRRQVEEAERLKQSAEEQAQARAQAQAAAEK-------LRKEAEQEAARRAQAEQAALR 2158
Query: 519 REKQSNQDLET---LSEELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSL-- 573
+++ ++ ++E +E+ +R+K Q++ ++ TL+ Q+++ + +K+ L+ + L
Sbjct: 2159 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL----QLEETDHQKNLLDEELQRLKA 2214
Query: 574 ------RERSQVSSEARMKDVEKENKALHQTVTEANGK---LSQLEFEKRQLHRDLEQAK 624
R+RSQV E V+ E + + EA + L + +R L + E+ K
Sbjct: 2215 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2274
Query: 625 EKGERAEKLE------RELQRLQEEN---------GRLARKVTSLETATE---KVEALEH 666
+ E A +L L++L EE+ L K+ +++ AT + E L+
Sbjct: 2275 QVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2334
Query: 667 ESQGLQLENRTLRKSLDTL-QNVSLQLEGLERDNKQLDAENLELRRLVETMRFTSTKLAQ 725
+ + Q + R L++ + + Q ++ + +G +R + LE+ E ++ ++A+
Sbjct: 2335 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL---RVAE 2391
Query: 726 MERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLE----SSSHK 781
M R + E + + RK + +G+K R EL+ Q E + L Q+LE S H
Sbjct: 2392 MSRAQARAEEDAQRFRKQAE---EIGEKLHRTELATQ----EKVTLVQTLEIQRQQSDHD 2444
Query: 782 TQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQ---LEKDKKLLE 838
+ L + ELE E++ L+++ + L+L + +++ ++++ E + Q L + LL+
Sbjct: 2445 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2504
Query: 839 KEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDNRDLTK 898
+E +E+E L++ +D K ++L ++ + +
Sbjct: 2505 RE----------------------RFIEQEKAKLEQLF---QDEVAKAQQLREEQQRQQQ 2539
Query: 899 QVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSDTKYK 958
Q+ + L E+ + ++++ + Q+LE+ +E LL E++ + +
Sbjct: 2540 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2599
Query: 959 ILEGRNESAL 968
+LE ++ +AL
Sbjct: 2600 LLEEQHRAAL 2609
Score = 115 bits (289), Expect = 3e-25
Identities = 180/779 (23%), Positives = 323/779 (41%), Gaps = 104/779 (13%)
Query: 247 EDKQHLAVELADTKARLRRVRQELEDKTEQLVDTRHE--VDQLVLELQKVKQENI----Q 300
E+ + L AR ++ QE K Q + H V Q ELQ+ Q+ Q
Sbjct: 2019 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2078
Query: 301 LAADARSARAYRDELDSLREKANRVERLELELTRCKEKLHDVDFYKARMEELREDNIILI 360
L +A +AR +E + R +A R E + + ++ + + K EE
Sbjct: 2079 LRGEAEAARRAAEEAEEARVQAER------EAAQSRRQVEEAERLKQSAEE--------- 2123
Query: 361 ETKAMLEEQLTAARARGDKVHELEK----ENLQLKSKLHDLELDRDTDKKRIEELLEENM 416
+ +A + Q A + R + E + E L+ K + + + KK E+ L +
Sbjct: 2124 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK-QAADAEMEKHKKFAEQTLRQKA 2182
Query: 417 VLEIAQKQSMNESAHLGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQ 476
+E E L +LE+ +L D + E E A R ++E+E S++
Sbjct: 2183 QVE-------QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS-QVEEELFSVR 2234
Query: 477 STIQGLRDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLS---EE 533
++ L +E +K+N Q LQ + E+ KQ ++ LS +E
Sbjct: 2235 VQMEELSKLKARIEAENRALILRDKDNTQ-----RFLQEEAEKMKQVAEEAARLSVAAQE 2289
Query: 534 LIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENK 593
R ++ + D+ +A + +K+ M +++E +++ +EA + +KE
Sbjct: 2290 AARLRQLAEEDLAQQRALAEKMLKE----------KMQAVQEATRLKAEAELLQQQKEL- 2338
Query: 594 ALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQ-RLQEENGRLARKVT 652
A + +L+ +K Q+ + L + + +R + ER+ Q + E RL +V
Sbjct: 2339 --------AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2390
Query: 653 SLETATEKVE--ALEHESQGLQLENRTLRKSLDTLQNVSL-QLEGLERDNKQLDAENL-- 707
+ A + E A Q ++ + R L T + V+L Q ++R DAE L
Sbjct: 2391 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2450
Query: 708 ---ELRRLVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSV 764
EL R E ++ KL Q++ E Q ++++ L++ L ++ + + L + +
Sbjct: 2451 AIAELEREKEKLQ-QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI 2509
Query: 765 SAENLRLQQSLESSSHKTQTLESELG----ELEAERQALRRDLE-ALRLANAQLEGAEKD 819
E +L+Q + K Q L E ++E ERQ L +E A R + EG +
Sbjct: 2510 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2569
Query: 820 RKALEQEVAQLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARC 879
++ L+Q Q + ++LL +E +RL +Q++L + + A V A K L
Sbjct: 2570 QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNG 2629
Query: 880 RDAA-GKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSS--ELDKLSQELE 936
RDA G E E ++ + LR + ++L+ + S EL +L+Q
Sbjct: 2630 RDALDGPAAEAEPEH------------SFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2677
Query: 937 KVGLNRELLLQED-----DSGSDTKYKILEGRNE-----SALKTTLAMKEEKIVLLEAQ 985
V EL +ED S +L+ NE +AL+ L ++LLEAQ
Sbjct: 2678 TVD---ELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQ 2733
Score = 60.1 bits (144), Expect = 2e-08
Identities = 210/986 (21%), Positives = 366/986 (37%), Gaps = 189/986 (19%)
Query: 490 EESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSDMETLK 549
EE G + + L +LE +++ ++L+ + L+RE + +E+ +
Sbjct: 638 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 697
Query: 550 ADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQ---TVTEANGKL 606
A Q WS + EA +K EN A Q V EA G+L
Sbjct: 698 AALQTQ---------------WSWMLQLCCCIEAHLK----ENAAYFQFFSDVREAEGQL 738
Query: 607 SQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGRL-------------ARKVTS 653
+L+ R+ + + ++ +LE LQ Q+E +L A+ V
Sbjct: 739 QKLQEALRRKY-----SCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQ 793
Query: 654 LETAT-----------------EKVEALEHESQGLQLENRTLRKSLDTLQNVSLQL---- 692
L+ ++VE H+ QL L + +
Sbjct: 794 LKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPS 853
Query: 693 ---------EGLERDNKQLDAENLELRRLVETMRFTSTKLAQMERENQQLEREKEELRK- 742
+ + +L+A++ L L + L Q L R+ + +R
Sbjct: 854 VCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAW----QSLRRDVQLIRSW 909
Query: 743 NVDLLKALGKKSER-----LELSYQSVSAEN-----------LRLQQSLESSSHKTQTLE 786
++ + L + +R LEL YQ+ ++ L ++ S SH Q L
Sbjct: 910 SLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLL 969
Query: 787 SELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQ 846
L + E +R + L+ QLE E +L DK+ + A+R+ +
Sbjct: 970 QSLEQGAQEESRCQRCISELKDIRLQLEACE----TRTVHRLRLPLDKEPARECAQRIAE 1025
Query: 847 QVELKDAV--LDDSTAKLSAVEKESRALDKELARCRDAAGKLK-ELEKDNRDLTKQVTVH 903
Q + + V L A+LSA ++ AL + AA L+ ELE LT
Sbjct: 1026 QQKAQAEVEGLGKGVARLSAEAEKVLALPEP----SPAAPTLRSELE-----LTLGKLEQ 1076
Query: 904 ARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDS---------GSD 954
R+L+ + LEKLK+ L + + +Q E+V E L+E + +
Sbjct: 1077 VRSLSA----IYLEKLKTISL---VIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK 1129
Query: 955 TKYKILEGRNESALKTTLAMKEE-------KIVLLEAQMEEKASLNRQLESELQMLKKEC 1007
K L + E+ T A+++E L + E + R E Q+L++
Sbjct: 1130 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1189
Query: 1008 ETLRQ---NQGEGQHLQNSFKH------PAG---KTAASHQGK-EAWGPGHKEATMELLR 1054
L Q Q E + L ++ P G + A Q + +A +A E LR
Sbjct: 1190 AVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLR 1249
Query: 1055 VKDRAI-ELERNNAALQAEKQLLKEQLQHL---ETQNVTFSSQI--LTLQKQSAFLQEHN 1108
+ + E+ER+ ++ ++ K+ + + E Q VT+ +Q+ + + +Q +
Sbjct: 1250 QEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1309
Query: 1109 TTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETENESLQRQQ----EQLTAAY 1164
++ + L+ S L++ LT+QY + + E E L QQ + A
Sbjct: 1310 ESVIQEYVDLRTHYSELTT----LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1365
Query: 1165 EALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAELE 1224
EA L+ L H + A+ E K L + ++ E E D ++K ++
Sbjct: 1366 EAALEKQRQLAEAHAQAKAQAERE------AKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1419
Query: 1225 EREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQL----------KGEYEE 1274
E + L EA Q + A A E RLR E + + + QL +GE +
Sbjct: 1420 EELQQLRQSSEAEIQAKARQAEA-AERSRLRIE-EEIRVVRLQLEATERQRGGAEGELQA 1477
Query: 1275 LHAHTKELKTSLNNAQLELNRWQARFDELKEQHQTMDISLTKLDNHCELLSRLKGNLEEE 1334
L A +E + AQ E R + Q D S K EL SR+K E
Sbjct: 1478 LRARAEEAEAQKRQAQEEAERL---------RRQVQDESQRKRQAEVELASRVKAEAEAA 1528
Query: 1335 NH-----HLLSQIQLLSQQNQMLLEQ 1355
L +++L +++ + L Q
Sbjct: 1529 REKQRALQALEELRLQAEEAERRLRQ 1554
Score = 41.2 bits (95), Expect = 0.010
Identities = 95/403 (23%), Positives = 166/403 (41%), Gaps = 61/403 (15%)
Query: 519 REKQSNQDLETLSEELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQ 578
R S +++E L + ++ KE ++ +ADK R K + Q + +A + +
Sbjct: 306 RFPSSFEEIEILWSQFLKFKEM---ELPAKEADKNRS-KGIYQSLEGAVQA-----GQLK 356
Query: 579 VSSEARMKDVEKENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQ 638
V DVEKE LH + LE EK Q + + ER E L+R +
Sbjct: 357 VPPGYHPLDVEKEWGKLHVAI---------LEREK--------QLRSEFERLECLQRIVT 399
Query: 639 RLQEENGRLARKVTSLET-------------ATEKVEALEHESQGLQLENRTLRKSLDTL 685
+LQ E G ++ + ++ +E + R L + TL
Sbjct: 400 KLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTL 459
Query: 686 QN-VSLQLEGLERDNKQLDAENLELR-----RLVETMRFTSTKLAQMERENQQLEREKEE 739
++ Q E + R +L + +R RL + +T++AQ+ ++ Q E E+
Sbjct: 460 KDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELED 519
Query: 740 --LRKNVDLLKALGKKSERLE-----LSYQSVSAE---NLRLQQSLESSSHKTQTLESEL 789
LR DLL + + R++ + SV A+ + L QS+E K + S+
Sbjct: 520 STLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDE 579
Query: 790 GELE-AERQALRRDLEALRLANAQLEGAEKDR----KALEQEVAQLEKDKKLL-EKEAKR 843
G+L A R A R L L L A+L + K R ++L VA K+ L EKE +
Sbjct: 580 GQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEE 639
Query: 844 LWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKL 886
+ ++ + SA+ +E +K++ ++A +L
Sbjct: 640 VGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRL 682
Score = 39.7 bits (91), Expect = 0.030
Identities = 160/919 (17%), Positives = 365/919 (39%), Gaps = 102/919 (11%)
Query: 614 RQLHRDLEQAKEKGERAEKLERELQ-----RLQEENGRLARKVTS-LETATEKVEALEHE 667
R LH+ +E+ + K ERA E +L ++ GRL + L ++ ++ +LE
Sbjct: 559 RGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESL 618
Query: 668 SQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVETMRFTSTKLAQME 727
+ + L L+ + + + +R N + A+ L+ + K+ +++
Sbjct: 619 HSFVAAATKEL-MWLNEKEEEEVGFDWSDR-NTNMTAKKESYSALMRELELKEKKIKELQ 676
Query: 728 RENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSSHKTQTLES 787
+L RE R V+ +A + Q L+++ + E+
Sbjct: 677 NAGDRLLREDHPARPTVESFQA--ALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREA 734
Query: 788 ELGELEAERQALRRDLEALRLAN-AQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQ 846
E G+L+ ++ALRR R A +LE +D + E QL + K L AKR
Sbjct: 735 E-GQLQKLQEALRRKYSCDRSATVTRLEDLLQD---AQDEKEQLNEYKGHLSGLAKRAKA 790
Query: 847 QVELKD--------------AVLD----------------------------DSTAKLSA 864
V+LK AV D S+ +A
Sbjct: 791 VVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAA 850
Query: 865 VEKESRALDKELARCRDAAGKLKELEKDNRDLTKQVTVHARTL---TTLREDLVLEKLKS 921
V + ++A +L+ + L Q+ V ++L +LR D+ L ++S
Sbjct: 851 VPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQL--IRS 908
Query: 922 QQLSS----ELDKLSQELEKVGLNRELLLQ--EDDSGSDTKYKILEGRNESALKTTLAMK 975
L++ + ++ Q L + L+ + L+ +D G + +++ R +
Sbjct: 909 WSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHY--- 965
Query: 976 EEKIVLLEAQMEEKASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTA--- 1032
++ + LE +E++ R + SEL+ ++ + E L K PA + A
Sbjct: 966 QQLLQSLEQGAQEESRCQRCI-SELKDIRLQLEACETRTVHRLRLPLD-KEPARECAQRI 1023
Query: 1033 ASHQGKEAWGPGHKEATMELLRVKDRAIELERNNAA---LQAEKQLLKEQLQHLETQNVT 1089
A Q +A G + L ++ + L + A L++E +L +L+ + + +
Sbjct: 1024 AEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1083
Query: 1090 FSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETE 1149
+ ++ T+ Q L+ +L+ E + + L A L+ E +
Sbjct: 1084 YLEKLKTISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKASLKKLRAQAEAQ 1142
Query: 1150 NESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKEL 1209
+ +++L A E E L H + E E R+ L ++
Sbjct: 1143 QPTFDALRDELRGAQEV----GERLQQRHGERDVEVERW-RERVAQLLERWQAVLAQTDV 1197
Query: 1210 GERHGDMLKRKAEL--EEREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQ 1267
+R + L R+ E + + ++A +++++ A+ + ++Q +R +L + L +
Sbjct: 1198 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1257
Query: 1268 LK--GE-YEELHAHTKELKTSLNNAQLELNRWQARFDEL---KEQHQTMDISLTKLDNHC 1321
++ GE EE K+ ++ + +L+L ++A+ + + ++ + S + + +
Sbjct: 1258 IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYV 1317
Query: 1322 EL---LSRLKGNLEEENHHLLSQIQLLSQQNQMLLEQNMENKEQYHE-----EQKQYIDK 1373
+L S L + + ++ + ++ ++ +Q E +E+ E E+++ + +
Sbjct: 1318 DLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAE 1377
Query: 1374 LNALRRHKEKLEEKIMDQYKFYDPPPKKKNHWIGAKALVKLIKPKKEGSRERLKSTVDSP 1433
+A + + + E K + Q + + +++ + A+ + I+ + + R+ ++ + +
Sbjct: 1378 AHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1436
Query: 1434 PWQLESSDPASPAASQPLR 1452
Q E+++ + + +R
Sbjct: 1437 ARQAEAAERSRLRIEEEIR 1455
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 168 bits (426), Expect = 4e-41
Identities = 277/1208 (22%), Positives = 494/1208 (40%), Gaps = 127/1208 (10%)
Query: 252 LAVELAD--TKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSAR 309
+A+E A +A L+ R +KT QL + E V +L++ + Q A+A AR
Sbjct: 1569 VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1628
Query: 310 AYRD-ELDSLREKANRVERLELELTRCKEKLHDVDFYKARMEELREDNIILIETKAMLEE 368
+ EL+ + KAN RL L+ +E +A E+ +E+ + EE
Sbjct: 1629 EEAERELERWQLKANEALRLRLQ---AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEE 1685
Query: 369 QLTAARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIEELLEENMVLEIAQKQSMNE 428
Q A R R ELEK+ +L T ++R+ +E + L +Q +
Sbjct: 1686 Q--AVRQRELAEQELEKQR----------QLAEGTAQQRLAAE-QELIRLRAETEQGEQQ 1732
Query: 429 SAHLGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASLV 488
L EL +L + A + R+ EL + + + L + ++ + + +
Sbjct: 1733 RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1792
Query: 489 LEESGLKCGELEKENHQLSKKIE--KLQTQLEREKQSNQDLETLSEELIREKEQLQSDME 546
LE + EL +E +L E K Q QL E + Q E +E ++ EK +
Sbjct: 1793 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE--AERVLAEKLAAIGEAT 1850
Query: 547 TLKADKARQIKDLEQEKDHLNRAMWS---LRERSQVSSEARMKDVEKE----NKALHQTV 599
LK + +K+ E E + L R R R + + D+E+ KA +
Sbjct: 1851 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1910
Query: 600 TEANGKLSQLEFEKRQLHRDLEQAKEKGERAE----KLERELQRLQE--ENGRLARKVTS 653
G + ++RQ+ ++ K E+A +LE EL R++ E+ +++
Sbjct: 1911 ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 1970
Query: 654 LETATEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLV 713
LE A ++ A E E + + E R ++KSL + + Q + + ++L A+ E RRL
Sbjct: 1971 LEAARQRQLAAEEERRRREAEER-VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLR 2029
Query: 714 ETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQ 773
E S + Q+ +E Q + EE A+ +K + L+ + Q + +L+
Sbjct: 2030 ERAEQESARQLQLAQEAAQKRLQAEEKAHAF----AVQQKEQELQQTLQQEQSVLDQLRG 2085
Query: 774 SLESSSHKTQTLESELGELEAERQAL--RRDLEALRLANAQLEGAEKDRKALEQEVAQLE 831
E++ + E+E ++AER+A RR +E A + AE+ +A Q A E
Sbjct: 2086 EAEAARRAAE--EAEEARVQAEREAAQSRRQVEE---AERLKQSAEEQAQARAQAQAAAE 2140
Query: 832 KDKKLLEKEAKRLWQ-------QVELKDAVLDDSTAKLSAVEKESRALDKELARCR---- 880
K +K E+EA R Q Q + DA ++ ++ +++EL R
Sbjct: 2141 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2200
Query: 881 DAAGKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGL 940
+ + L+++ + L + T AR + + E+L +++ ++LS ++ E
Sbjct: 2201 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE------ 2254
Query: 941 NRELLLQEDDSGS----DTKYKILEGRNESALKTTLAMK--------EEKIVLLEAQMEE 988
NR L+L++ D+ + K+ + E+A + A + EE + A E+
Sbjct: 2255 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEK 2314
Query: 989 KASLNRQLESELQMLKKECETLRQN----QGEGQHLQNSFKHPAGKTAASHQG----KEA 1040
Q E LK E E L+Q Q + + LQ + A + A QG EA
Sbjct: 2315 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2374
Query: 1041 WGPGHKEATMELLRVKDRAIELERNNAALQAEKQLLKEQLQH---------LETQNVTFS 1091
E + E R+K R E+ R A + + Q ++Q + L TQ
Sbjct: 2375 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2434
Query: 1092 SQILTLQKQSAF-----LQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAK 1146
Q L +Q+Q + L+E L+ + KLQ E L +S + +Q +
Sbjct: 2435 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQT----VQQEQLLQ 2490
Query: 1147 ETE--NESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLEL 1204
ET+ +S +++ L + Q+ L L + + A+ + L + + + +E
Sbjct: 2491 ETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ---QRQQQQMEQ 2547
Query: 1205 EHKELGERHGDMLKRKAELEEREKVLTTEREALQQEQRTNA-LAMGENQRLRGELDRVNF 1263
E + L + +R+ E EE + E + L+Q++R L ENQRLR +L +
Sbjct: 2548 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEE 2607
Query: 1264 LHHQLKGEYEELHAHTKELKTSLNNAQLELNRWQAR------FDELKEQHQTMDISLTKL 1317
H EE+ A +L N + L+ A FD L+ + + +
Sbjct: 2608 QHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGI 2667
Query: 1318 DNHCELLSRLKGNL--------EEENHHLLSQIQLLSQQNQMLLEQNMENKEQYHEEQKQ 1369
+ EL +G+ E+ H+L + + +LL+ E Y Q+Q
Sbjct: 2668 LSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAG----LLLKATNEKLSVYAALQRQ 2723
Query: 1370 YIDKLNAL 1377
+ AL
Sbjct: 2724 LLSPGTAL 2731
Score = 158 bits (399), Expect = 6e-38
Identities = 294/1385 (21%), Positives = 558/1385 (40%), Gaps = 161/1385 (11%)
Query: 176 ELPDVAPEELEALSRSMVLHLRRLIDQRD--ECTELIVDLTQERDYLQAQHPPSPIKSSS 233
EL D+ + LEA V LR +D+ EC + I + Q++ + + + S
Sbjct: 992 ELKDIRLQ-LEACETRTVHRLRLPLDKEPARECAQRIAE--QQKAQAEVEGLGKGVARLS 1048
Query: 234 ADSTPSPTSSLSSEDKQHLAVELADTKARLRRVR-----------------------QEL 270
A++ S L EL T +L +VR +E+
Sbjct: 1049 AEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEV 1108
Query: 271 EDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSAR----AYRDELDSLREKANRVE 326
E+ + V + EL+ K +L A A + + A RDEL +E R++
Sbjct: 1109 LRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQ 1168
Query: 327 RL----ELELTRCKEK-----------LHDVDFYKARMEELREDNIILIETKAMLEEQLT 371
+ ++E+ R +E+ L D + +E+L E+ L L
Sbjct: 1169 QRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQ 1228
Query: 372 AARARGDKVHELEKENLQ-LKSKLHDLELDRDTDKKRIEELLEENMVLEIAQ---KQSMN 427
AR R +++ + + Q ++ +L ++ +EE+ +E Q KQ +N
Sbjct: 1229 DARRRQEQIQAMPLADSQAVREQLRQ-------EQALLEEIERHGEKVEECQRFAKQYIN 1281
Query: 428 ESAHLGWELEQLSKNADL---SDASRKSFVFELNECASSRILKLEKENQSLQS-TIQGLR 483
A +EL+ ++ A L + ++K V +E + L L + T Q ++
Sbjct: 1282 --AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK 1339
Query: 484 DASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQS 543
S L + E++ + +++ +++ LE+++Q + + RE ++LQ
Sbjct: 1340 FISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1399
Query: 544 DMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKA--------- 594
M+ + D +Q+K + + LR+ S+ +A+ + E ++
Sbjct: 1400 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1459
Query: 595 ---LHQTVTE-----ANGKLSQLEFEKRQLHRDLEQAKEKGERAEK-LERELQRLQEENG 645
L TE A G+L L + QA+E+ ER + ++ E QR ++
Sbjct: 1460 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1519
Query: 646 RLARKV-TSLETATEKVEAL----EHESQGLQLENRTLRKSLDTLQNVSLQLEGLERD-- 698
LA +V E A EK AL E Q + E R + ++ + V + LE +R
Sbjct: 1520 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1579
Query: 699 -----------------NKQLDAENLELRRLVETMRFTSTKLAQMERENQQLEREKE--E 739
+ L E++ + +L E + + A+ ER ++ ERE E +
Sbjct: 1580 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1639
Query: 740 LRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLES----SSHKTQTLESELGELEAE 795
L+ N L L + + S AE + + E+ + + + EL E E E
Sbjct: 1640 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1699
Query: 796 R----------QALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLW 845
+ Q L + E +RL A+ E E+ R+ LE+E+A+L+++ ++ + L
Sbjct: 1700 KQRQLAEGTAQQRLAAEQELIRL-RAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1758
Query: 846 QQVELKDAVLDDSTAKLSAVEKESRAL-DKELARCRDAAGKLKELEKDNRDLTKQVTVHA 904
++ A ++ A + E+ESR+ +K R AG+ +EL ++ L
Sbjct: 1759 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1818
Query: 905 RTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSDTKYKILEGRN 964
R ED ++ +++++ +E E ++ E+ L+E ++ ++ ++ E +
Sbjct: 1819 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE--D 1876
Query: 965 ESALKTTLAMKEEKIVLLEAQMEEK-ASLNRQLESELQMLKKECE-TLRQN---QGEGQH 1019
E+ + L EE+ +A +EE+ A L + +SEL+ K E TLRQ + E
Sbjct: 1877 EAFQRRRL---EEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA 1933
Query: 1020 LQNSF-KHPAGKTAAS------HQGKEAWGPGHKEATMELLRVKDRAIELE--RNNAALQ 1070
L+ SF K AGK E ++A +E R + A E E R A +
Sbjct: 1934 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 1993
Query: 1071 AEKQLLKEQLQHLETQNVTFSSQILTLQKQSA----FLQEHNTTLQTQTAKLQVENSTLS 1126
+K L E+ + + + L + + A E + Q Q A+ + +
Sbjct: 1994 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2053
Query: 1127 SQSAALTAQYTLLQNHHTAKETENESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYE 1186
+ A A Q + E L + + + AA A ++ E ER++A+
Sbjct: 2054 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA-AEEAEEARVQAEREAAQSR 2112
Query: 1187 ALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAELEEREKVLTTEREALQQEQRTNAL 1246
+ + LK + + + + + L+++AE +E + E+ AL+Q+Q +A
Sbjct: 2113 RQVEEAERLKQSAEE-QAQARAQAQAAAEKLRKEAE-QEAARRAQAEQAALRQKQAADA- 2169
Query: 1247 AMGENQRLRGELDRVNFLHHQLKGEYEELHAHTKELKTSLNNAQLELNRWQARFDELKEQ 1306
E ++ + ++ Q++ E L +E N EL R +A E Q
Sbjct: 2170 ---EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2226
Query: 1307 HQTMDISLTKLDNHCELLSRLKGNLEEENHHLLSQIQLLSQQNQMLLEQNMENKEQYHEE 1366
++ L + E LS+LK +E EN L+ + + Q L++ E +Q EE
Sbjct: 2227 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK---DNTQRFLQEEAEKMKQVAEE 2283
Query: 1367 QKQYIDKLNALRRHKEKLEEKIMDQYKFYDPPPKKKNHWI----GAKALVKLIKPKKEGS 1422
+ R ++ EE + Q + K+K + KA +L++ +KE +
Sbjct: 2284 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA 2343
Query: 1423 RERLK 1427
+E+ +
Sbjct: 2344 QEQAR 2348
Score = 119 bits (299), Expect = 2e-26
Identities = 167/790 (21%), Positives = 355/790 (44%), Gaps = 131/790 (16%)
Query: 249 KQHLAVELADTKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSA 308
++ A AD + RL ++R+ + + E+ + V+ + + ++V++E + L A A
Sbjct: 1885 EEQAAQHKADIEERLAQLRKASDSELER---QKGLVEDTLRQRRQVEEEILALKASFEKA 1941
Query: 309 RAYRDEL------------DSLREKANRVERLELELTRCKEKLHDVDFYKARMEELREDN 356
A + EL D+LR K E+ ELE R ++ + + + EE + +
Sbjct: 1942 AAGKAELELELGRIRSNAEDTLRSK----EQAELEAARQRQLAAEEERRRREAEERVQKS 1997
Query: 357 IILIET-----KAMLEEQLTAARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIE-- 409
+ E KA LEE + +A+ ++ L + Q ++ L+L ++ +KR++
Sbjct: 1998 LAAEEEAARQRKAALEE-VERLKAKVEEARRLRERAEQESAR--QLQLAQEAAQKRLQAE 2054
Query: 410 --------ELLEENMVLEIAQKQSMNESAHLGWELEQLSKNADLSDASRKSFVFELNECA 461
+ E+ + + Q+QS+ + L E E + A+ ++ +R V E A
Sbjct: 2055 EKAHAFAVQQKEQELQQTLQQEQSVLDQ--LRGEAEAARRAAEEAEEAR---VQAEREAA 2109
Query: 462 SSR--ILKLEKENQSLQSTIQGLRDASLVLEESGLKCGELEKENHQ-LSKKIEKLQTQLE 518
SR + + E+ QS + Q A E+ L KE Q +++ + Q L
Sbjct: 2110 QSRRQVEEAERLKQSAEEQAQARAQAQAAAEK-------LRKEAEQEAARRAQAEQAALR 2162
Query: 519 REKQSNQDLET---LSEELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSL-- 573
+++ ++ ++E +E+ +R+K Q++ ++ TL+ Q+++ + +K+ L+ + L
Sbjct: 2163 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL----QLEETDHQKNLLDEELQRLKA 2218
Query: 574 ------RERSQVSSEARMKDVEKENKALHQTVTEANGK---LSQLEFEKRQLHRDLEQAK 624
R+RSQV E V+ E + + EA + L + +R L + E+ K
Sbjct: 2219 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2278
Query: 625 EKGERAEKLE------RELQRLQEEN---------GRLARKVTSLETATE---KVEALEH 666
+ E A +L L++L EE+ L K+ +++ AT + E L+
Sbjct: 2279 QVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2338
Query: 667 ESQGLQLENRTLRKSLDTL-QNVSLQLEGLERDNKQLDAENLELRRLVETMRFTSTKLAQ 725
+ + Q + R L++ + + Q ++ + +G +R + LE+ E ++ ++A+
Sbjct: 2339 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL---RVAE 2395
Query: 726 MERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLE----SSSHK 781
M R + E + + RK + +G+K R EL+ Q E + L Q+LE S H
Sbjct: 2396 MSRAQARAEEDAQRFRKQAE---EIGEKLHRTELATQ----EKVTLVQTLEIQRQQSDHD 2448
Query: 782 TQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQ---LEKDKKLLE 838
+ L + ELE E++ L+++ + L+L + +++ ++++ E + Q L + LL+
Sbjct: 2449 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2508
Query: 839 KEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDNRDLTK 898
+E +E+E L++ +D K ++L ++ + +
Sbjct: 2509 RE----------------------RFIEQEKAKLEQLF---QDEVAKAQQLREEQQRQQQ 2543
Query: 899 QVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSDTKYK 958
Q+ + L E+ + ++++ + Q+LE+ +E LL E++ + +
Sbjct: 2544 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2603
Query: 959 ILEGRNESAL 968
+LE ++ +AL
Sbjct: 2604 LLEEQHRAAL 2613
Score = 115 bits (289), Expect = 3e-25
Identities = 180/779 (23%), Positives = 323/779 (41%), Gaps = 104/779 (13%)
Query: 247 EDKQHLAVELADTKARLRRVRQELEDKTEQLVDTRHE--VDQLVLELQKVKQENI----Q 300
E+ + L AR ++ QE K Q + H V Q ELQ+ Q+ Q
Sbjct: 2023 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2082
Query: 301 LAADARSARAYRDELDSLREKANRVERLELELTRCKEKLHDVDFYKARMEELREDNIILI 360
L +A +AR +E + R +A R E + + ++ + + K EE
Sbjct: 2083 LRGEAEAARRAAEEAEEARVQAER------EAAQSRRQVEEAERLKQSAEE--------- 2127
Query: 361 ETKAMLEEQLTAARARGDKVHELEK----ENLQLKSKLHDLELDRDTDKKRIEELLEENM 416
+ +A + Q A + R + E + E L+ K + + + KK E+ L +
Sbjct: 2128 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK-QAADAEMEKHKKFAEQTLRQKA 2186
Query: 417 VLEIAQKQSMNESAHLGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQ 476
+E E L +LE+ +L D + E E A R ++E+E S++
Sbjct: 2187 QVE-------QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS-QVEEELFSVR 2238
Query: 477 STIQGLRDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLS---EE 533
++ L +E +K+N Q LQ + E+ KQ ++ LS +E
Sbjct: 2239 VQMEELSKLKARIEAENRALILRDKDNTQ-----RFLQEEAEKMKQVAEEAARLSVAAQE 2293
Query: 534 LIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENK 593
R ++ + D+ +A + +K+ M +++E +++ +EA + +KE
Sbjct: 2294 AARLRQLAEEDLAQQRALAEKMLKE----------KMQAVQEATRLKAEAELLQQQKEL- 2342
Query: 594 ALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQ-RLQEENGRLARKVT 652
A + +L+ +K Q+ + L + + +R + ER+ Q + E RL +V
Sbjct: 2343 --------AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2394
Query: 653 SLETATEKVE--ALEHESQGLQLENRTLRKSLDTLQNVSL-QLEGLERDNKQLDAENL-- 707
+ A + E A Q ++ + R L T + V+L Q ++R DAE L
Sbjct: 2395 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2454
Query: 708 ---ELRRLVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSV 764
EL R E ++ KL Q++ E Q ++++ L++ L ++ + + L + +
Sbjct: 2455 AIAELEREKEKLQ-QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI 2513
Query: 765 SAENLRLQQSLESSSHKTQTLESELG----ELEAERQALRRDLE-ALRLANAQLEGAEKD 819
E +L+Q + K Q L E ++E ERQ L +E A R + EG +
Sbjct: 2514 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2573
Query: 820 RKALEQEVAQLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARC 879
++ L+Q Q + ++LL +E +RL +Q++L + + A V A K L
Sbjct: 2574 QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNG 2633
Query: 880 RDAA-GKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSS--ELDKLSQELE 936
RDA G E E ++ + LR + ++L+ + S EL +L+Q
Sbjct: 2634 RDALDGPAAEAEPEH------------SFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2681
Query: 937 KVGLNRELLLQED-----DSGSDTKYKILEGRNE-----SALKTTLAMKEEKIVLLEAQ 985
V EL +ED S +L+ NE +AL+ L ++LLEAQ
Sbjct: 2682 TVD---ELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQ 2737
Score = 60.1 bits (144), Expect = 2e-08
Identities = 210/986 (21%), Positives = 366/986 (37%), Gaps = 189/986 (19%)
Query: 490 EESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSDMETLK 549
EE G + + L +LE +++ ++L+ + L+RE + +E+ +
Sbjct: 642 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 701
Query: 550 ADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQ---TVTEANGKL 606
A Q WS + EA +K EN A Q V EA G+L
Sbjct: 702 AALQTQ---------------WSWMLQLCCCIEAHLK----ENAAYFQFFSDVREAEGQL 742
Query: 607 SQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGRL-------------ARKVTS 653
+L+ R+ + + ++ +LE LQ Q+E +L A+ V
Sbjct: 743 QKLQEALRRKY-----SCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQ 797
Query: 654 LETAT-----------------EKVEALEHESQGLQLENRTLRKSLDTLQNVSLQL---- 692
L+ ++VE H+ QL L + +
Sbjct: 798 LKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPS 857
Query: 693 ---------EGLERDNKQLDAENLELRRLVETMRFTSTKLAQMERENQQLEREKEELRK- 742
+ + +L+A++ L L + L Q L R+ + +R
Sbjct: 858 VCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAW----QSLRRDVQLIRSW 913
Query: 743 NVDLLKALGKKSER-----LELSYQSVSAEN-----------LRLQQSLESSSHKTQTLE 786
++ + L + +R LEL YQ+ ++ L ++ S SH Q L
Sbjct: 914 SLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLL 973
Query: 787 SELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQ 846
L + E +R + L+ QLE E +L DK+ + A+R+ +
Sbjct: 974 QSLEQGAQEESRCQRCISELKDIRLQLEACE----TRTVHRLRLPLDKEPARECAQRIAE 1029
Query: 847 QVELKDAV--LDDSTAKLSAVEKESRALDKELARCRDAAGKLK-ELEKDNRDLTKQVTVH 903
Q + + V L A+LSA ++ AL + AA L+ ELE LT
Sbjct: 1030 QQKAQAEVEGLGKGVARLSAEAEKVLALPEP----SPAAPTLRSELE-----LTLGKLEQ 1080
Query: 904 ARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDS---------GSD 954
R+L+ + LEKLK+ L + + +Q E+V E L+E + +
Sbjct: 1081 VRSLSA----IYLEKLKTISL---VIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK 1133
Query: 955 TKYKILEGRNESALKTTLAMKEE-------KIVLLEAQMEEKASLNRQLESELQMLKKEC 1007
K L + E+ T A+++E L + E + R E Q+L++
Sbjct: 1134 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1193
Query: 1008 ETLRQ---NQGEGQHLQNSFKH------PAG---KTAASHQGK-EAWGPGHKEATMELLR 1054
L Q Q E + L ++ P G + A Q + +A +A E LR
Sbjct: 1194 AVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLR 1253
Query: 1055 VKDRAI-ELERNNAALQAEKQLLKEQLQHL---ETQNVTFSSQI--LTLQKQSAFLQEHN 1108
+ + E+ER+ ++ ++ K+ + + E Q VT+ +Q+ + + +Q +
Sbjct: 1254 QEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1313
Query: 1109 TTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETENESLQRQQ----EQLTAAY 1164
++ + L+ S L++ LT+QY + + E E L QQ + A
Sbjct: 1314 ESVIQEYVDLRTHYSELTT----LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1369
Query: 1165 EALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAELE 1224
EA L+ L H + A+ E K L + ++ E E D ++K ++
Sbjct: 1370 EAALEKQRQLAEAHAQAKAQAERE------AKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1423
Query: 1225 EREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQL----------KGEYEE 1274
E + L EA Q + A A E RLR E + + + QL +GE +
Sbjct: 1424 EELQQLRQSSEAEIQAKARQAEA-AERSRLRIE-EEIRVVRLQLEATERQRGGAEGELQA 1481
Query: 1275 LHAHTKELKTSLNNAQLELNRWQARFDELKEQHQTMDISLTKLDNHCELLSRLKGNLEEE 1334
L A +E + AQ E R + Q D S K EL SR+K E
Sbjct: 1482 LRARAEEAEAQKRQAQEEAERL---------RRQVQDESQRKRQAEVELASRVKAEAEAA 1532
Query: 1335 NH-----HLLSQIQLLSQQNQMLLEQ 1355
L +++L +++ + L Q
Sbjct: 1533 REKQRALQALEELRLQAEEAERRLRQ 1558
Score = 41.2 bits (95), Expect = 0.010
Identities = 95/403 (23%), Positives = 166/403 (41%), Gaps = 61/403 (15%)
Query: 519 REKQSNQDLETLSEELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQ 578
R S +++E L + ++ KE ++ +ADK R K + Q + +A + +
Sbjct: 310 RFPSSFEEIEILWSQFLKFKEM---ELPAKEADKNRS-KGIYQSLEGAVQA-----GQLK 360
Query: 579 VSSEARMKDVEKENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQ 638
V DVEKE LH + LE EK Q + + ER E L+R +
Sbjct: 361 VPPGYHPLDVEKEWGKLHVAI---------LEREK--------QLRSEFERLECLQRIVT 403
Query: 639 RLQEENGRLARKVTSLET-------------ATEKVEALEHESQGLQLENRTLRKSLDTL 685
+LQ E G ++ + ++ +E + R L + TL
Sbjct: 404 KLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTL 463
Query: 686 QN-VSLQLEGLERDNKQLDAENLELR-----RLVETMRFTSTKLAQMERENQQLEREKEE 739
++ Q E + R +L + +R RL + +T++AQ+ ++ Q E E+
Sbjct: 464 KDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELED 523
Query: 740 --LRKNVDLLKALGKKSERLE-----LSYQSVSAE---NLRLQQSLESSSHKTQTLESEL 789
LR DLL + + R++ + SV A+ + L QS+E K + S+
Sbjct: 524 STLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDE 583
Query: 790 GELE-AERQALRRDLEALRLANAQLEGAEKDR----KALEQEVAQLEKDKKLL-EKEAKR 843
G+L A R A R L L L A+L + K R ++L VA K+ L EKE +
Sbjct: 584 GQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEE 643
Query: 844 LWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKL 886
+ ++ + SA+ +E +K++ ++A +L
Sbjct: 644 VGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRL 686
Score = 39.7 bits (91), Expect = 0.030
Identities = 160/919 (17%), Positives = 365/919 (39%), Gaps = 102/919 (11%)
Query: 614 RQLHRDLEQAKEKGERAEKLERELQ-----RLQEENGRLARKVTS-LETATEKVEALEHE 667
R LH+ +E+ + K ERA E +L ++ GRL + L ++ ++ +LE
Sbjct: 563 RGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESL 622
Query: 668 SQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVETMRFTSTKLAQME 727
+ + L L+ + + + +R N + A+ L+ + K+ +++
Sbjct: 623 HSFVAAATKEL-MWLNEKEEEEVGFDWSDR-NTNMTAKKESYSALMRELELKEKKIKELQ 680
Query: 728 RENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSSHKTQTLES 787
+L RE R V+ +A + Q L+++ + E+
Sbjct: 681 NAGDRLLREDHPARPTVESFQA--ALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREA 738
Query: 788 ELGELEAERQALRRDLEALRLAN-AQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQ 846
E G+L+ ++ALRR R A +LE +D + E QL + K L AKR
Sbjct: 739 E-GQLQKLQEALRRKYSCDRSATVTRLEDLLQD---AQDEKEQLNEYKGHLSGLAKRAKA 794
Query: 847 QVELKD--------------AVLD----------------------------DSTAKLSA 864
V+LK AV D S+ +A
Sbjct: 795 VVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAA 854
Query: 865 VEKESRALDKELARCRDAAGKLKELEKDNRDLTKQVTVHARTL---TTLREDLVLEKLKS 921
V + ++A +L+ + L Q+ V ++L +LR D+ L ++S
Sbjct: 855 VPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQL--IRS 912
Query: 922 QQLSS----ELDKLSQELEKVGLNRELLLQ--EDDSGSDTKYKILEGRNESALKTTLAMK 975
L++ + ++ Q L + L+ + L+ +D G + +++ R +
Sbjct: 913 WSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHY--- 969
Query: 976 EEKIVLLEAQMEEKASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTA--- 1032
++ + LE +E++ R + SEL+ ++ + E L K PA + A
Sbjct: 970 QQLLQSLEQGAQEESRCQRCI-SELKDIRLQLEACETRTVHRLRLPLD-KEPARECAQRI 1027
Query: 1033 ASHQGKEAWGPGHKEATMELLRVKDRAIELERNNAA---LQAEKQLLKEQLQHLETQNVT 1089
A Q +A G + L ++ + L + A L++E +L +L+ + + +
Sbjct: 1028 AEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1087
Query: 1090 FSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETE 1149
+ ++ T+ Q L+ +L+ E + + L A L+ E +
Sbjct: 1088 YLEKLKTISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKASLKKLRAQAEAQ 1146
Query: 1150 NESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKEL 1209
+ +++L A E E L H + E E R+ L ++
Sbjct: 1147 QPTFDALRDELRGAQEV----GERLQQRHGERDVEVERW-RERVAQLLERWQAVLAQTDV 1201
Query: 1210 GERHGDMLKRKAEL--EEREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQ 1267
+R + L R+ E + + ++A +++++ A+ + ++Q +R +L + L +
Sbjct: 1202 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1261
Query: 1268 LK--GE-YEELHAHTKELKTSLNNAQLELNRWQARFDEL---KEQHQTMDISLTKLDNHC 1321
++ GE EE K+ ++ + +L+L ++A+ + + ++ + S + + +
Sbjct: 1262 IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYV 1321
Query: 1322 EL---LSRLKGNLEEENHHLLSQIQLLSQQNQMLLEQNMENKEQYHE-----EQKQYIDK 1373
+L S L + + ++ + ++ ++ +Q E +E+ E E+++ + +
Sbjct: 1322 DLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAE 1381
Query: 1374 LNALRRHKEKLEEKIMDQYKFYDPPPKKKNHWIGAKALVKLIKPKKEGSRERLKSTVDSP 1433
+A + + + E K + Q + + +++ + A+ + I+ + + R+ ++ + +
Sbjct: 1382 AHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1440
Query: 1434 PWQLESSDPASPAASQPLR 1452
Q E+++ + + +R
Sbjct: 1441 ARQAEAAERSRLRIEEEIR 1459
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 168 bits (426), Expect = 4e-41
Identities = 277/1208 (22%), Positives = 494/1208 (40%), Gaps = 127/1208 (10%)
Query: 252 LAVELAD--TKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSAR 309
+A+E A +A L+ R +KT QL + E V +L++ + Q A+A AR
Sbjct: 1565 VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1624
Query: 310 AYRD-ELDSLREKANRVERLELELTRCKEKLHDVDFYKARMEELREDNIILIETKAMLEE 368
+ EL+ + KAN RL L+ +E +A E+ +E+ + EE
Sbjct: 1625 EEAERELERWQLKANEALRLRLQ---AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEE 1681
Query: 369 QLTAARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIEELLEENMVLEIAQKQSMNE 428
Q A R R ELEK+ +L T ++R+ +E + L +Q +
Sbjct: 1682 Q--AVRQRELAEQELEKQR----------QLAEGTAQQRLAAE-QELIRLRAETEQGEQQ 1728
Query: 429 SAHLGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASLV 488
L EL +L + A + R+ EL + + + L + ++ + + +
Sbjct: 1729 RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1788
Query: 489 LEESGLKCGELEKENHQLSKKIE--KLQTQLEREKQSNQDLETLSEELIREKEQLQSDME 546
LE + EL +E +L E K Q QL E + Q E +E ++ EK +
Sbjct: 1789 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE--AERVLAEKLAAIGEAT 1846
Query: 547 TLKADKARQIKDLEQEKDHLNRAMWS---LRERSQVSSEARMKDVEKE----NKALHQTV 599
LK + +K+ E E + L R R R + + D+E+ KA +
Sbjct: 1847 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1906
Query: 600 TEANGKLSQLEFEKRQLHRDLEQAKEKGERAE----KLERELQRLQE--ENGRLARKVTS 653
G + ++RQ+ ++ K E+A +LE EL R++ E+ +++
Sbjct: 1907 ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 1966
Query: 654 LETATEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLV 713
LE A ++ A E E + + E R ++KSL + + Q + + ++L A+ E RRL
Sbjct: 1967 LEAARQRQLAAEEERRRREAEER-VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLR 2025
Query: 714 ETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQ 773
E S + Q+ +E Q + EE A+ +K + L+ + Q + +L+
Sbjct: 2026 ERAEQESARQLQLAQEAAQKRLQAEEKAHAF----AVQQKEQELQQTLQQEQSVLDQLRG 2081
Query: 774 SLESSSHKTQTLESELGELEAERQAL--RRDLEALRLANAQLEGAEKDRKALEQEVAQLE 831
E++ + E+E ++AER+A RR +E A + AE+ +A Q A E
Sbjct: 2082 EAEAARRAAE--EAEEARVQAEREAAQSRRQVEE---AERLKQSAEEQAQARAQAQAAAE 2136
Query: 832 KDKKLLEKEAKRLWQ-------QVELKDAVLDDSTAKLSAVEKESRALDKELARCR---- 880
K +K E+EA R Q Q + DA ++ ++ +++EL R
Sbjct: 2137 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2196
Query: 881 DAAGKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGL 940
+ + L+++ + L + T AR + + E+L +++ ++LS ++ E
Sbjct: 2197 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE------ 2250
Query: 941 NRELLLQEDDSGS----DTKYKILEGRNESALKTTLAMK--------EEKIVLLEAQMEE 988
NR L+L++ D+ + K+ + E+A + A + EE + A E+
Sbjct: 2251 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEK 2310
Query: 989 KASLNRQLESELQMLKKECETLRQN----QGEGQHLQNSFKHPAGKTAASHQG----KEA 1040
Q E LK E E L+Q Q + + LQ + A + A QG EA
Sbjct: 2311 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2370
Query: 1041 WGPGHKEATMELLRVKDRAIELERNNAALQAEKQLLKEQLQH---------LETQNVTFS 1091
E + E R+K R E+ R A + + Q ++Q + L TQ
Sbjct: 2371 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2430
Query: 1092 SQILTLQKQSAF-----LQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAK 1146
Q L +Q+Q + L+E L+ + KLQ E L +S + +Q +
Sbjct: 2431 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQT----VQQEQLLQ 2486
Query: 1147 ETE--NESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLEL 1204
ET+ +S +++ L + Q+ L L + + A+ + L + + + +E
Sbjct: 2487 ETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ---QRQQQQMEQ 2543
Query: 1205 EHKELGERHGDMLKRKAELEEREKVLTTEREALQQEQRTNA-LAMGENQRLRGELDRVNF 1263
E + L + +R+ E EE + E + L+Q++R L ENQRLR +L +
Sbjct: 2544 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEE 2603
Query: 1264 LHHQLKGEYEELHAHTKELKTSLNNAQLELNRWQAR------FDELKEQHQTMDISLTKL 1317
H EE+ A +L N + L+ A FD L+ + + +
Sbjct: 2604 QHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGI 2663
Query: 1318 DNHCELLSRLKGNL--------EEENHHLLSQIQLLSQQNQMLLEQNMENKEQYHEEQKQ 1369
+ EL +G+ E+ H+L + + +LL+ E Y Q+Q
Sbjct: 2664 LSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAG----LLLKATNEKLSVYAALQRQ 2719
Query: 1370 YIDKLNAL 1377
+ AL
Sbjct: 2720 LLSPGTAL 2727
Score = 158 bits (399), Expect = 6e-38
Identities = 294/1385 (21%), Positives = 558/1385 (40%), Gaps = 161/1385 (11%)
Query: 176 ELPDVAPEELEALSRSMVLHLRRLIDQRD--ECTELIVDLTQERDYLQAQHPPSPIKSSS 233
EL D+ + LEA V LR +D+ EC + I + Q++ + + + S
Sbjct: 988 ELKDIRLQ-LEACETRTVHRLRLPLDKEPARECAQRIAE--QQKAQAEVEGLGKGVARLS 1044
Query: 234 ADSTPSPTSSLSSEDKQHLAVELADTKARLRRVR-----------------------QEL 270
A++ S L EL T +L +VR +E+
Sbjct: 1045 AEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEV 1104
Query: 271 EDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSAR----AYRDELDSLREKANRVE 326
E+ + V + EL+ K +L A A + + A RDEL +E R++
Sbjct: 1105 LRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQ 1164
Query: 327 RL----ELELTRCKEK-----------LHDVDFYKARMEELREDNIILIETKAMLEEQLT 371
+ ++E+ R +E+ L D + +E+L E+ L L
Sbjct: 1165 QRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQ 1224
Query: 372 AARARGDKVHELEKENLQ-LKSKLHDLELDRDTDKKRIEELLEENMVLEIAQ---KQSMN 427
AR R +++ + + Q ++ +L ++ +EE+ +E Q KQ +N
Sbjct: 1225 DARRRQEQIQAMPLADSQAVREQLRQ-------EQALLEEIERHGEKVEECQRFAKQYIN 1277
Query: 428 ESAHLGWELEQLSKNADL---SDASRKSFVFELNECASSRILKLEKENQSLQS-TIQGLR 483
A +EL+ ++ A L + ++K V +E + L L + T Q ++
Sbjct: 1278 --AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK 1335
Query: 484 DASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQS 543
S L + E++ + +++ +++ LE+++Q + + RE ++LQ
Sbjct: 1336 FISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1395
Query: 544 DMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKA--------- 594
M+ + D +Q+K + + LR+ S+ +A+ + E ++
Sbjct: 1396 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1455
Query: 595 ---LHQTVTE-----ANGKLSQLEFEKRQLHRDLEQAKEKGERAEK-LERELQRLQEENG 645
L TE A G+L L + QA+E+ ER + ++ E QR ++
Sbjct: 1456 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1515
Query: 646 RLARKV-TSLETATEKVEAL----EHESQGLQLENRTLRKSLDTLQNVSLQLEGLERD-- 698
LA +V E A EK AL E Q + E R + ++ + V + LE +R
Sbjct: 1516 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1575
Query: 699 -----------------NKQLDAENLELRRLVETMRFTSTKLAQMERENQQLEREKE--E 739
+ L E++ + +L E + + A+ ER ++ ERE E +
Sbjct: 1576 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1635
Query: 740 LRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLES----SSHKTQTLESELGELEAE 795
L+ N L L + + S AE + + E+ + + + EL E E E
Sbjct: 1636 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1695
Query: 796 R----------QALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLW 845
+ Q L + E +RL A+ E E+ R+ LE+E+A+L+++ ++ + L
Sbjct: 1696 KQRQLAEGTAQQRLAAEQELIRL-RAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1754
Query: 846 QQVELKDAVLDDSTAKLSAVEKESRAL-DKELARCRDAAGKLKELEKDNRDLTKQVTVHA 904
++ A ++ A + E+ESR+ +K R AG+ +EL ++ L
Sbjct: 1755 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1814
Query: 905 RTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSDTKYKILEGRN 964
R ED ++ +++++ +E E ++ E+ L+E ++ ++ ++ E +
Sbjct: 1815 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE--D 1872
Query: 965 ESALKTTLAMKEEKIVLLEAQMEEK-ASLNRQLESELQMLKKECE-TLRQN---QGEGQH 1019
E+ + L EE+ +A +EE+ A L + +SEL+ K E TLRQ + E
Sbjct: 1873 EAFQRRRL---EEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA 1929
Query: 1020 LQNSF-KHPAGKTAAS------HQGKEAWGPGHKEATMELLRVKDRAIELE--RNNAALQ 1070
L+ SF K AGK E ++A +E R + A E E R A +
Sbjct: 1930 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 1989
Query: 1071 AEKQLLKEQLQHLETQNVTFSSQILTLQKQSA----FLQEHNTTLQTQTAKLQVENSTLS 1126
+K L E+ + + + L + + A E + Q Q A+ + +
Sbjct: 1990 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2049
Query: 1127 SQSAALTAQYTLLQNHHTAKETENESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYE 1186
+ A A Q + E L + + + AA A ++ E ER++A+
Sbjct: 2050 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA-AEEAEEARVQAEREAAQSR 2108
Query: 1187 ALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAELEEREKVLTTEREALQQEQRTNAL 1246
+ + LK + + + + + L+++AE +E + E+ AL+Q+Q +A
Sbjct: 2109 RQVEEAERLKQSAEE-QAQARAQAQAAAEKLRKEAE-QEAARRAQAEQAALRQKQAADA- 2165
Query: 1247 AMGENQRLRGELDRVNFLHHQLKGEYEELHAHTKELKTSLNNAQLELNRWQARFDELKEQ 1306
E ++ + ++ Q++ E L +E N EL R +A E Q
Sbjct: 2166 ---EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2222
Query: 1307 HQTMDISLTKLDNHCELLSRLKGNLEEENHHLLSQIQLLSQQNQMLLEQNMENKEQYHEE 1366
++ L + E LS+LK +E EN L+ + + Q L++ E +Q EE
Sbjct: 2223 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK---DNTQRFLQEEAEKMKQVAEE 2279
Query: 1367 QKQYIDKLNALRRHKEKLEEKIMDQYKFYDPPPKKKNHWI----GAKALVKLIKPKKEGS 1422
+ R ++ EE + Q + K+K + KA +L++ +KE +
Sbjct: 2280 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA 2339
Query: 1423 RERLK 1427
+E+ +
Sbjct: 2340 QEQAR 2344
Score = 119 bits (299), Expect = 2e-26
Identities = 167/790 (21%), Positives = 355/790 (44%), Gaps = 131/790 (16%)
Query: 249 KQHLAVELADTKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSA 308
++ A AD + RL ++R+ + + E+ + V+ + + ++V++E + L A A
Sbjct: 1881 EEQAAQHKADIEERLAQLRKASDSELER---QKGLVEDTLRQRRQVEEEILALKASFEKA 1937
Query: 309 RAYRDEL------------DSLREKANRVERLELELTRCKEKLHDVDFYKARMEELREDN 356
A + EL D+LR K E+ ELE R ++ + + + EE + +
Sbjct: 1938 AAGKAELELELGRIRSNAEDTLRSK----EQAELEAARQRQLAAEEERRRREAEERVQKS 1993
Query: 357 IILIET-----KAMLEEQLTAARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIE-- 409
+ E KA LEE + +A+ ++ L + Q ++ L+L ++ +KR++
Sbjct: 1994 LAAEEEAARQRKAALEE-VERLKAKVEEARRLRERAEQESAR--QLQLAQEAAQKRLQAE 2050
Query: 410 --------ELLEENMVLEIAQKQSMNESAHLGWELEQLSKNADLSDASRKSFVFELNECA 461
+ E+ + + Q+QS+ + L E E + A+ ++ +R V E A
Sbjct: 2051 EKAHAFAVQQKEQELQQTLQQEQSVLDQ--LRGEAEAARRAAEEAEEAR---VQAEREAA 2105
Query: 462 SSR--ILKLEKENQSLQSTIQGLRDASLVLEESGLKCGELEKENHQ-LSKKIEKLQTQLE 518
SR + + E+ QS + Q A E+ L KE Q +++ + Q L
Sbjct: 2106 QSRRQVEEAERLKQSAEEQAQARAQAQAAAEK-------LRKEAEQEAARRAQAEQAALR 2158
Query: 519 REKQSNQDLET---LSEELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSL-- 573
+++ ++ ++E +E+ +R+K Q++ ++ TL+ Q+++ + +K+ L+ + L
Sbjct: 2159 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL----QLEETDHQKNLLDEELQRLKA 2214
Query: 574 ------RERSQVSSEARMKDVEKENKALHQTVTEANGK---LSQLEFEKRQLHRDLEQAK 624
R+RSQV E V+ E + + EA + L + +R L + E+ K
Sbjct: 2215 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2274
Query: 625 EKGERAEKLE------RELQRLQEEN---------GRLARKVTSLETATE---KVEALEH 666
+ E A +L L++L EE+ L K+ +++ AT + E L+
Sbjct: 2275 QVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2334
Query: 667 ESQGLQLENRTLRKSLDTL-QNVSLQLEGLERDNKQLDAENLELRRLVETMRFTSTKLAQ 725
+ + Q + R L++ + + Q ++ + +G +R + LE+ E ++ ++A+
Sbjct: 2335 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL---RVAE 2391
Query: 726 MERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLE----SSSHK 781
M R + E + + RK + +G+K R EL+ Q E + L Q+LE S H
Sbjct: 2392 MSRAQARAEEDAQRFRKQAE---EIGEKLHRTELATQ----EKVTLVQTLEIQRQQSDHD 2444
Query: 782 TQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQ---LEKDKKLLE 838
+ L + ELE E++ L+++ + L+L + +++ ++++ E + Q L + LL+
Sbjct: 2445 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2504
Query: 839 KEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDNRDLTK 898
+E +E+E L++ +D K ++L ++ + +
Sbjct: 2505 RE----------------------RFIEQEKAKLEQLF---QDEVAKAQQLREEQQRQQQ 2539
Query: 899 QVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSDTKYK 958
Q+ + L E+ + ++++ + Q+LE+ +E LL E++ + +
Sbjct: 2540 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2599
Query: 959 ILEGRNESAL 968
+LE ++ +AL
Sbjct: 2600 LLEEQHRAAL 2609
Score = 115 bits (289), Expect = 3e-25
Identities = 180/779 (23%), Positives = 323/779 (41%), Gaps = 104/779 (13%)
Query: 247 EDKQHLAVELADTKARLRRVRQELEDKTEQLVDTRHE--VDQLVLELQKVKQENI----Q 300
E+ + L AR ++ QE K Q + H V Q ELQ+ Q+ Q
Sbjct: 2019 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2078
Query: 301 LAADARSARAYRDELDSLREKANRVERLELELTRCKEKLHDVDFYKARMEELREDNIILI 360
L +A +AR +E + R +A R E + + ++ + + K EE
Sbjct: 2079 LRGEAEAARRAAEEAEEARVQAER------EAAQSRRQVEEAERLKQSAEE--------- 2123
Query: 361 ETKAMLEEQLTAARARGDKVHELEK----ENLQLKSKLHDLELDRDTDKKRIEELLEENM 416
+ +A + Q A + R + E + E L+ K + + + KK E+ L +
Sbjct: 2124 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK-QAADAEMEKHKKFAEQTLRQKA 2182
Query: 417 VLEIAQKQSMNESAHLGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQ 476
+E E L +LE+ +L D + E E A R ++E+E S++
Sbjct: 2183 QVE-------QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS-QVEEELFSVR 2234
Query: 477 STIQGLRDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLS---EE 533
++ L +E +K+N Q LQ + E+ KQ ++ LS +E
Sbjct: 2235 VQMEELSKLKARIEAENRALILRDKDNTQ-----RFLQEEAEKMKQVAEEAARLSVAAQE 2289
Query: 534 LIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENK 593
R ++ + D+ +A + +K+ M +++E +++ +EA + +KE
Sbjct: 2290 AARLRQLAEEDLAQQRALAEKMLKE----------KMQAVQEATRLKAEAELLQQQKEL- 2338
Query: 594 ALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQ-RLQEENGRLARKVT 652
A + +L+ +K Q+ + L + + +R + ER+ Q + E RL +V
Sbjct: 2339 --------AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2390
Query: 653 SLETATEKVE--ALEHESQGLQLENRTLRKSLDTLQNVSL-QLEGLERDNKQLDAENL-- 707
+ A + E A Q ++ + R L T + V+L Q ++R DAE L
Sbjct: 2391 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2450
Query: 708 ---ELRRLVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSV 764
EL R E ++ KL Q++ E Q ++++ L++ L ++ + + L + +
Sbjct: 2451 AIAELEREKEKLQ-QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI 2509
Query: 765 SAENLRLQQSLESSSHKTQTLESELG----ELEAERQALRRDLE-ALRLANAQLEGAEKD 819
E +L+Q + K Q L E ++E ERQ L +E A R + EG +
Sbjct: 2510 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2569
Query: 820 RKALEQEVAQLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARC 879
++ L+Q Q + ++LL +E +RL +Q++L + + A V A K L
Sbjct: 2570 QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNG 2629
Query: 880 RDAA-GKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSS--ELDKLSQELE 936
RDA G E E ++ + LR + ++L+ + S EL +L+Q
Sbjct: 2630 RDALDGPAAEAEPEH------------SFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2677
Query: 937 KVGLNRELLLQED-----DSGSDTKYKILEGRNE-----SALKTTLAMKEEKIVLLEAQ 985
V EL +ED S +L+ NE +AL+ L ++LLEAQ
Sbjct: 2678 TVD---ELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQ 2733
Score = 60.1 bits (144), Expect = 2e-08
Identities = 210/986 (21%), Positives = 366/986 (37%), Gaps = 189/986 (19%)
Query: 490 EESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSDMETLK 549
EE G + + L +LE +++ ++L+ + L+RE + +E+ +
Sbjct: 638 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 697
Query: 550 ADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQ---TVTEANGKL 606
A Q WS + EA +K EN A Q V EA G+L
Sbjct: 698 AALQTQ---------------WSWMLQLCCCIEAHLK----ENAAYFQFFSDVREAEGQL 738
Query: 607 SQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGRL-------------ARKVTS 653
+L+ R+ + + ++ +LE LQ Q+E +L A+ V
Sbjct: 739 QKLQEALRRKY-----SCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQ 793
Query: 654 LETAT-----------------EKVEALEHESQGLQLENRTLRKSLDTLQNVSLQL---- 692
L+ ++VE H+ QL L + +
Sbjct: 794 LKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPS 853
Query: 693 ---------EGLERDNKQLDAENLELRRLVETMRFTSTKLAQMERENQQLEREKEELRK- 742
+ + +L+A++ L L + L Q L R+ + +R
Sbjct: 854 VCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAW----QSLRRDVQLIRSW 909
Query: 743 NVDLLKALGKKSER-----LELSYQSVSAEN-----------LRLQQSLESSSHKTQTLE 786
++ + L + +R LEL YQ+ ++ L ++ S SH Q L
Sbjct: 910 SLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLL 969
Query: 787 SELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQ 846
L + E +R + L+ QLE E +L DK+ + A+R+ +
Sbjct: 970 QSLEQGAQEESRCQRCISELKDIRLQLEACE----TRTVHRLRLPLDKEPARECAQRIAE 1025
Query: 847 QVELKDAV--LDDSTAKLSAVEKESRALDKELARCRDAAGKLK-ELEKDNRDLTKQVTVH 903
Q + + V L A+LSA ++ AL + AA L+ ELE LT
Sbjct: 1026 QQKAQAEVEGLGKGVARLSAEAEKVLALPEP----SPAAPTLRSELE-----LTLGKLEQ 1076
Query: 904 ARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDS---------GSD 954
R+L+ + LEKLK+ L + + +Q E+V E L+E + +
Sbjct: 1077 VRSLSA----IYLEKLKTISL---VIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK 1129
Query: 955 TKYKILEGRNESALKTTLAMKEE-------KIVLLEAQMEEKASLNRQLESELQMLKKEC 1007
K L + E+ T A+++E L + E + R E Q+L++
Sbjct: 1130 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1189
Query: 1008 ETLRQ---NQGEGQHLQNSFKH------PAG---KTAASHQGK-EAWGPGHKEATMELLR 1054
L Q Q E + L ++ P G + A Q + +A +A E LR
Sbjct: 1190 AVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLR 1249
Query: 1055 VKDRAI-ELERNNAALQAEKQLLKEQLQHL---ETQNVTFSSQI--LTLQKQSAFLQEHN 1108
+ + E+ER+ ++ ++ K+ + + E Q VT+ +Q+ + + +Q +
Sbjct: 1250 QEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1309
Query: 1109 TTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETENESLQRQQ----EQLTAAY 1164
++ + L+ S L++ LT+QY + + E E L QQ + A
Sbjct: 1310 ESVIQEYVDLRTHYSELTT----LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1365
Query: 1165 EALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAELE 1224
EA L+ L H + A+ E K L + ++ E E D ++K ++
Sbjct: 1366 EAALEKQRQLAEAHAQAKAQAERE------AKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1419
Query: 1225 EREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQL----------KGEYEE 1274
E + L EA Q + A A E RLR E + + + QL +GE +
Sbjct: 1420 EELQQLRQSSEAEIQAKARQAEA-AERSRLRIE-EEIRVVRLQLEATERQRGGAEGELQA 1477
Query: 1275 LHAHTKELKTSLNNAQLELNRWQARFDELKEQHQTMDISLTKLDNHCELLSRLKGNLEEE 1334
L A +E + AQ E R + Q D S K EL SR+K E
Sbjct: 1478 LRARAEEAEAQKRQAQEEAERL---------RRQVQDESQRKRQAEVELASRVKAEAEAA 1528
Query: 1335 NH-----HLLSQIQLLSQQNQMLLEQ 1355
L +++L +++ + L Q
Sbjct: 1529 REKQRALQALEELRLQAEEAERRLRQ 1554
Score = 41.2 bits (95), Expect = 0.010
Identities = 95/403 (23%), Positives = 166/403 (41%), Gaps = 61/403 (15%)
Query: 519 REKQSNQDLETLSEELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQ 578
R S +++E L + ++ KE ++ +ADK R K + Q + +A + +
Sbjct: 306 RFPSSFEEIEILWSQFLKFKEM---ELPAKEADKNRS-KGIYQSLEGAVQA-----GQLK 356
Query: 579 VSSEARMKDVEKENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQ 638
V DVEKE LH + LE EK Q + + ER E L+R +
Sbjct: 357 VPPGYHPLDVEKEWGKLHVAI---------LEREK--------QLRSEFERLECLQRIVT 399
Query: 639 RLQEENGRLARKVTSLET-------------ATEKVEALEHESQGLQLENRTLRKSLDTL 685
+LQ E G ++ + ++ +E + R L + TL
Sbjct: 400 KLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTL 459
Query: 686 QN-VSLQLEGLERDNKQLDAENLELR-----RLVETMRFTSTKLAQMERENQQLEREKEE 739
++ Q E + R +L + +R RL + +T++AQ+ ++ Q E E+
Sbjct: 460 KDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELED 519
Query: 740 --LRKNVDLLKALGKKSERLE-----LSYQSVSAE---NLRLQQSLESSSHKTQTLESEL 789
LR DLL + + R++ + SV A+ + L QS+E K + S+
Sbjct: 520 STLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDE 579
Query: 790 GELE-AERQALRRDLEALRLANAQLEGAEKDR----KALEQEVAQLEKDKKLL-EKEAKR 843
G+L A R A R L L L A+L + K R ++L VA K+ L EKE +
Sbjct: 580 GQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEE 639
Query: 844 LWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKL 886
+ ++ + SA+ +E +K++ ++A +L
Sbjct: 640 VGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRL 682
Score = 39.7 bits (91), Expect = 0.030
Identities = 160/919 (17%), Positives = 365/919 (39%), Gaps = 102/919 (11%)
Query: 614 RQLHRDLEQAKEKGERAEKLERELQ-----RLQEENGRLARKVTS-LETATEKVEALEHE 667
R LH+ +E+ + K ERA E +L ++ GRL + L ++ ++ +LE
Sbjct: 559 RGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESL 618
Query: 668 SQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVETMRFTSTKLAQME 727
+ + L L+ + + + +R N + A+ L+ + K+ +++
Sbjct: 619 HSFVAAATKEL-MWLNEKEEEEVGFDWSDR-NTNMTAKKESYSALMRELELKEKKIKELQ 676
Query: 728 RENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSSHKTQTLES 787
+L RE R V+ +A + Q L+++ + E+
Sbjct: 677 NAGDRLLREDHPARPTVESFQA--ALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREA 734
Query: 788 ELGELEAERQALRRDLEALRLAN-AQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQ 846
E G+L+ ++ALRR R A +LE +D + E QL + K L AKR
Sbjct: 735 E-GQLQKLQEALRRKYSCDRSATVTRLEDLLQD---AQDEKEQLNEYKGHLSGLAKRAKA 790
Query: 847 QVELKD--------------AVLD----------------------------DSTAKLSA 864
V+LK AV D S+ +A
Sbjct: 791 VVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAA 850
Query: 865 VEKESRALDKELARCRDAAGKLKELEKDNRDLTKQVTVHARTL---TTLREDLVLEKLKS 921
V + ++A +L+ + L Q+ V ++L +LR D+ L ++S
Sbjct: 851 VPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQL--IRS 908
Query: 922 QQLSS----ELDKLSQELEKVGLNRELLLQ--EDDSGSDTKYKILEGRNESALKTTLAMK 975
L++ + ++ Q L + L+ + L+ +D G + +++ R +
Sbjct: 909 WSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHY--- 965
Query: 976 EEKIVLLEAQMEEKASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTA--- 1032
++ + LE +E++ R + SEL+ ++ + E L K PA + A
Sbjct: 966 QQLLQSLEQGAQEESRCQRCI-SELKDIRLQLEACETRTVHRLRLPLD-KEPARECAQRI 1023
Query: 1033 ASHQGKEAWGPGHKEATMELLRVKDRAIELERNNAA---LQAEKQLLKEQLQHLETQNVT 1089
A Q +A G + L ++ + L + A L++E +L +L+ + + +
Sbjct: 1024 AEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1083
Query: 1090 FSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETE 1149
+ ++ T+ Q L+ +L+ E + + L A L+ E +
Sbjct: 1084 YLEKLKTISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKASLKKLRAQAEAQ 1142
Query: 1150 NESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKEL 1209
+ +++L A E E L H + E E R+ L ++
Sbjct: 1143 QPTFDALRDELRGAQEV----GERLQQRHGERDVEVERW-RERVAQLLERWQAVLAQTDV 1197
Query: 1210 GERHGDMLKRKAEL--EEREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQ 1267
+R + L R+ E + + ++A +++++ A+ + ++Q +R +L + L +
Sbjct: 1198 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1257
Query: 1268 LK--GE-YEELHAHTKELKTSLNNAQLELNRWQARFDEL---KEQHQTMDISLTKLDNHC 1321
++ GE EE K+ ++ + +L+L ++A+ + + ++ + S + + +
Sbjct: 1258 IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYV 1317
Query: 1322 EL---LSRLKGNLEEENHHLLSQIQLLSQQNQMLLEQNMENKEQYHE-----EQKQYIDK 1373
+L S L + + ++ + ++ ++ +Q E +E+ E E+++ + +
Sbjct: 1318 DLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAE 1377
Query: 1374 LNALRRHKEKLEEKIMDQYKFYDPPPKKKNHWIGAKALVKLIKPKKEGSRERLKSTVDSP 1433
+A + + + E K + Q + + +++ + A+ + I+ + + R+ ++ + +
Sbjct: 1378 AHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1436
Query: 1434 PWQLESSDPASPAASQPLR 1452
Q E+++ + + +R
Sbjct: 1437 ARQAEAAERSRLRIEEEIR 1455
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 168 bits (426), Expect = 4e-41
Identities = 277/1208 (22%), Positives = 494/1208 (40%), Gaps = 127/1208 (10%)
Query: 252 LAVELAD--TKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSAR 309
+A+E A +A L+ R +KT QL + E V +L++ + Q A+A AR
Sbjct: 1533 VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1592
Query: 310 AYRD-ELDSLREKANRVERLELELTRCKEKLHDVDFYKARMEELREDNIILIETKAMLEE 368
+ EL+ + KAN RL L+ +E +A E+ +E+ + EE
Sbjct: 1593 EEAERELERWQLKANEALRLRLQ---AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEE 1649
Query: 369 QLTAARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIEELLEENMVLEIAQKQSMNE 428
Q A R R ELEK+ +L T ++R+ +E + L +Q +
Sbjct: 1650 Q--AVRQRELAEQELEKQR----------QLAEGTAQQRLAAE-QELIRLRAETEQGEQQ 1696
Query: 429 SAHLGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASLV 488
L EL +L + A + R+ EL + + + L + ++ + + +
Sbjct: 1697 RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1756
Query: 489 LEESGLKCGELEKENHQLSKKIE--KLQTQLEREKQSNQDLETLSEELIREKEQLQSDME 546
LE + EL +E +L E K Q QL E + Q E +E ++ EK +
Sbjct: 1757 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE--AERVLAEKLAAIGEAT 1814
Query: 547 TLKADKARQIKDLEQEKDHLNRAMWS---LRERSQVSSEARMKDVEKE----NKALHQTV 599
LK + +K+ E E + L R R R + + D+E+ KA +
Sbjct: 1815 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1874
Query: 600 TEANGKLSQLEFEKRQLHRDLEQAKEKGERAE----KLERELQRLQE--ENGRLARKVTS 653
G + ++RQ+ ++ K E+A +LE EL R++ E+ +++
Sbjct: 1875 ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 1934
Query: 654 LETATEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLV 713
LE A ++ A E E + + E R ++KSL + + Q + + ++L A+ E RRL
Sbjct: 1935 LEAARQRQLAAEEERRRREAEER-VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLR 1993
Query: 714 ETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQ 773
E S + Q+ +E Q + EE A+ +K + L+ + Q + +L+
Sbjct: 1994 ERAEQESARQLQLAQEAAQKRLQAEEKAHAF----AVQQKEQELQQTLQQEQSVLDQLRG 2049
Query: 774 SLESSSHKTQTLESELGELEAERQAL--RRDLEALRLANAQLEGAEKDRKALEQEVAQLE 831
E++ + E+E ++AER+A RR +E A + AE+ +A Q A E
Sbjct: 2050 EAEAARRAAE--EAEEARVQAEREAAQSRRQVEE---AERLKQSAEEQAQARAQAQAAAE 2104
Query: 832 KDKKLLEKEAKRLWQ-------QVELKDAVLDDSTAKLSAVEKESRALDKELARCR---- 880
K +K E+EA R Q Q + DA ++ ++ +++EL R
Sbjct: 2105 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2164
Query: 881 DAAGKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGL 940
+ + L+++ + L + T AR + + E+L +++ ++LS ++ E
Sbjct: 2165 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE------ 2218
Query: 941 NRELLLQEDDSGS----DTKYKILEGRNESALKTTLAMK--------EEKIVLLEAQMEE 988
NR L+L++ D+ + K+ + E+A + A + EE + A E+
Sbjct: 2219 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEK 2278
Query: 989 KASLNRQLESELQMLKKECETLRQN----QGEGQHLQNSFKHPAGKTAASHQG----KEA 1040
Q E LK E E L+Q Q + + LQ + A + A QG EA
Sbjct: 2279 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2338
Query: 1041 WGPGHKEATMELLRVKDRAIELERNNAALQAEKQLLKEQLQH---------LETQNVTFS 1091
E + E R+K R E+ R A + + Q ++Q + L TQ
Sbjct: 2339 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2398
Query: 1092 SQILTLQKQSAF-----LQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAK 1146
Q L +Q+Q + L+E L+ + KLQ E L +S + +Q +
Sbjct: 2399 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQT----VQQEQLLQ 2454
Query: 1147 ETE--NESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLEL 1204
ET+ +S +++ L + Q+ L L + + A+ + L + + + +E
Sbjct: 2455 ETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ---QRQQQQMEQ 2511
Query: 1205 EHKELGERHGDMLKRKAELEEREKVLTTEREALQQEQRTNA-LAMGENQRLRGELDRVNF 1263
E + L + +R+ E EE + E + L+Q++R L ENQRLR +L +
Sbjct: 2512 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEE 2571
Query: 1264 LHHQLKGEYEELHAHTKELKTSLNNAQLELNRWQAR------FDELKEQHQTMDISLTKL 1317
H EE+ A +L N + L+ A FD L+ + + +
Sbjct: 2572 QHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGI 2631
Query: 1318 DNHCELLSRLKGNL--------EEENHHLLSQIQLLSQQNQMLLEQNMENKEQYHEEQKQ 1369
+ EL +G+ E+ H+L + + +LL+ E Y Q+Q
Sbjct: 2632 LSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAG----LLLKATNEKLSVYAALQRQ 2687
Query: 1370 YIDKLNAL 1377
+ AL
Sbjct: 2688 LLSPGTAL 2695
Score = 158 bits (399), Expect = 6e-38
Identities = 294/1385 (21%), Positives = 558/1385 (40%), Gaps = 161/1385 (11%)
Query: 176 ELPDVAPEELEALSRSMVLHLRRLIDQRD--ECTELIVDLTQERDYLQAQHPPSPIKSSS 233
EL D+ + LEA V LR +D+ EC + I + Q++ + + + S
Sbjct: 956 ELKDIRLQ-LEACETRTVHRLRLPLDKEPARECAQRIAE--QQKAQAEVEGLGKGVARLS 1012
Query: 234 ADSTPSPTSSLSSEDKQHLAVELADTKARLRRVR-----------------------QEL 270
A++ S L EL T +L +VR +E+
Sbjct: 1013 AEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEV 1072
Query: 271 EDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSAR----AYRDELDSLREKANRVE 326
E+ + V + EL+ K +L A A + + A RDEL +E R++
Sbjct: 1073 LRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQ 1132
Query: 327 RL----ELELTRCKEK-----------LHDVDFYKARMEELREDNIILIETKAMLEEQLT 371
+ ++E+ R +E+ L D + +E+L E+ L L
Sbjct: 1133 QRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQ 1192
Query: 372 AARARGDKVHELEKENLQ-LKSKLHDLELDRDTDKKRIEELLEENMVLEIAQ---KQSMN 427
AR R +++ + + Q ++ +L ++ +EE+ +E Q KQ +N
Sbjct: 1193 DARRRQEQIQAMPLADSQAVREQLRQ-------EQALLEEIERHGEKVEECQRFAKQYIN 1245
Query: 428 ESAHLGWELEQLSKNADL---SDASRKSFVFELNECASSRILKLEKENQSLQS-TIQGLR 483
A +EL+ ++ A L + ++K V +E + L L + T Q ++
Sbjct: 1246 --AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK 1303
Query: 484 DASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQS 543
S L + E++ + +++ +++ LE+++Q + + RE ++LQ
Sbjct: 1304 FISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1363
Query: 544 DMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKA--------- 594
M+ + D +Q+K + + LR+ S+ +A+ + E ++
Sbjct: 1364 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1423
Query: 595 ---LHQTVTE-----ANGKLSQLEFEKRQLHRDLEQAKEKGERAEK-LERELQRLQEENG 645
L TE A G+L L + QA+E+ ER + ++ E QR ++
Sbjct: 1424 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1483
Query: 646 RLARKV-TSLETATEKVEAL----EHESQGLQLENRTLRKSLDTLQNVSLQLEGLERD-- 698
LA +V E A EK AL E Q + E R + ++ + V + LE +R
Sbjct: 1484 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1543
Query: 699 -----------------NKQLDAENLELRRLVETMRFTSTKLAQMERENQQLEREKE--E 739
+ L E++ + +L E + + A+ ER ++ ERE E +
Sbjct: 1544 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1603
Query: 740 LRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLES----SSHKTQTLESELGELEAE 795
L+ N L L + + S AE + + E+ + + + EL E E E
Sbjct: 1604 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1663
Query: 796 R----------QALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLW 845
+ Q L + E +RL A+ E E+ R+ LE+E+A+L+++ ++ + L
Sbjct: 1664 KQRQLAEGTAQQRLAAEQELIRL-RAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1722
Query: 846 QQVELKDAVLDDSTAKLSAVEKESRAL-DKELARCRDAAGKLKELEKDNRDLTKQVTVHA 904
++ A ++ A + E+ESR+ +K R AG+ +EL ++ L
Sbjct: 1723 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1782
Query: 905 RTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSDTKYKILEGRN 964
R ED ++ +++++ +E E ++ E+ L+E ++ ++ ++ E +
Sbjct: 1783 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE--D 1840
Query: 965 ESALKTTLAMKEEKIVLLEAQMEEK-ASLNRQLESELQMLKKECE-TLRQN---QGEGQH 1019
E+ + L EE+ +A +EE+ A L + +SEL+ K E TLRQ + E
Sbjct: 1841 EAFQRRRL---EEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA 1897
Query: 1020 LQNSF-KHPAGKTAAS------HQGKEAWGPGHKEATMELLRVKDRAIELE--RNNAALQ 1070
L+ SF K AGK E ++A +E R + A E E R A +
Sbjct: 1898 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 1957
Query: 1071 AEKQLLKEQLQHLETQNVTFSSQILTLQKQSA----FLQEHNTTLQTQTAKLQVENSTLS 1126
+K L E+ + + + L + + A E + Q Q A+ + +
Sbjct: 1958 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2017
Query: 1127 SQSAALTAQYTLLQNHHTAKETENESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYE 1186
+ A A Q + E L + + + AA A ++ E ER++A+
Sbjct: 2018 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA-AEEAEEARVQAEREAAQSR 2076
Query: 1187 ALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAELEEREKVLTTEREALQQEQRTNAL 1246
+ + LK + + + + + L+++AE +E + E+ AL+Q+Q +A
Sbjct: 2077 RQVEEAERLKQSAEE-QAQARAQAQAAAEKLRKEAE-QEAARRAQAEQAALRQKQAADA- 2133
Query: 1247 AMGENQRLRGELDRVNFLHHQLKGEYEELHAHTKELKTSLNNAQLELNRWQARFDELKEQ 1306
E ++ + ++ Q++ E L +E N EL R +A E Q
Sbjct: 2134 ---EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2190
Query: 1307 HQTMDISLTKLDNHCELLSRLKGNLEEENHHLLSQIQLLSQQNQMLLEQNMENKEQYHEE 1366
++ L + E LS+LK +E EN L+ + + Q L++ E +Q EE
Sbjct: 2191 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK---DNTQRFLQEEAEKMKQVAEE 2247
Query: 1367 QKQYIDKLNALRRHKEKLEEKIMDQYKFYDPPPKKKNHWI----GAKALVKLIKPKKEGS 1422
+ R ++ EE + Q + K+K + KA +L++ +KE +
Sbjct: 2248 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA 2307
Query: 1423 RERLK 1427
+E+ +
Sbjct: 2308 QEQAR 2312
Score = 119 bits (299), Expect = 2e-26
Identities = 167/790 (21%), Positives = 355/790 (44%), Gaps = 131/790 (16%)
Query: 249 KQHLAVELADTKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSA 308
++ A AD + RL ++R+ + + E+ + V+ + + ++V++E + L A A
Sbjct: 1849 EEQAAQHKADIEERLAQLRKASDSELER---QKGLVEDTLRQRRQVEEEILALKASFEKA 1905
Query: 309 RAYRDEL------------DSLREKANRVERLELELTRCKEKLHDVDFYKARMEELREDN 356
A + EL D+LR K E+ ELE R ++ + + + EE + +
Sbjct: 1906 AAGKAELELELGRIRSNAEDTLRSK----EQAELEAARQRQLAAEEERRRREAEERVQKS 1961
Query: 357 IILIET-----KAMLEEQLTAARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIE-- 409
+ E KA LEE + +A+ ++ L + Q ++ L+L ++ +KR++
Sbjct: 1962 LAAEEEAARQRKAALEE-VERLKAKVEEARRLRERAEQESAR--QLQLAQEAAQKRLQAE 2018
Query: 410 --------ELLEENMVLEIAQKQSMNESAHLGWELEQLSKNADLSDASRKSFVFELNECA 461
+ E+ + + Q+QS+ + L E E + A+ ++ +R V E A
Sbjct: 2019 EKAHAFAVQQKEQELQQTLQQEQSVLDQ--LRGEAEAARRAAEEAEEAR---VQAEREAA 2073
Query: 462 SSR--ILKLEKENQSLQSTIQGLRDASLVLEESGLKCGELEKENHQ-LSKKIEKLQTQLE 518
SR + + E+ QS + Q A E+ L KE Q +++ + Q L
Sbjct: 2074 QSRRQVEEAERLKQSAEEQAQARAQAQAAAEK-------LRKEAEQEAARRAQAEQAALR 2126
Query: 519 REKQSNQDLET---LSEELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSL-- 573
+++ ++ ++E +E+ +R+K Q++ ++ TL+ Q+++ + +K+ L+ + L
Sbjct: 2127 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL----QLEETDHQKNLLDEELQRLKA 2182
Query: 574 ------RERSQVSSEARMKDVEKENKALHQTVTEANGK---LSQLEFEKRQLHRDLEQAK 624
R+RSQV E V+ E + + EA + L + +R L + E+ K
Sbjct: 2183 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2242
Query: 625 EKGERAEKLE------RELQRLQEEN---------GRLARKVTSLETATE---KVEALEH 666
+ E A +L L++L EE+ L K+ +++ AT + E L+
Sbjct: 2243 QVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2302
Query: 667 ESQGLQLENRTLRKSLDTL-QNVSLQLEGLERDNKQLDAENLELRRLVETMRFTSTKLAQ 725
+ + Q + R L++ + + Q ++ + +G +R + LE+ E ++ ++A+
Sbjct: 2303 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL---RVAE 2359
Query: 726 MERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLE----SSSHK 781
M R + E + + RK + +G+K R EL+ Q E + L Q+LE S H
Sbjct: 2360 MSRAQARAEEDAQRFRKQAE---EIGEKLHRTELATQ----EKVTLVQTLEIQRQQSDHD 2412
Query: 782 TQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQ---LEKDKKLLE 838
+ L + ELE E++ L+++ + L+L + +++ ++++ E + Q L + LL+
Sbjct: 2413 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2472
Query: 839 KEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDNRDLTK 898
+E +E+E L++ +D K ++L ++ + +
Sbjct: 2473 RE----------------------RFIEQEKAKLEQLF---QDEVAKAQQLREEQQRQQQ 2507
Query: 899 QVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSDTKYK 958
Q+ + L E+ + ++++ + Q+LE+ +E LL E++ + +
Sbjct: 2508 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2567
Query: 959 ILEGRNESAL 968
+LE ++ +AL
Sbjct: 2568 LLEEQHRAAL 2577
Score = 115 bits (289), Expect = 3e-25
Identities = 180/779 (23%), Positives = 323/779 (41%), Gaps = 104/779 (13%)
Query: 247 EDKQHLAVELADTKARLRRVRQELEDKTEQLVDTRHE--VDQLVLELQKVKQENI----Q 300
E+ + L AR ++ QE K Q + H V Q ELQ+ Q+ Q
Sbjct: 1987 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2046
Query: 301 LAADARSARAYRDELDSLREKANRVERLELELTRCKEKLHDVDFYKARMEELREDNIILI 360
L +A +AR +E + R +A R E + + ++ + + K EE
Sbjct: 2047 LRGEAEAARRAAEEAEEARVQAER------EAAQSRRQVEEAERLKQSAEE--------- 2091
Query: 361 ETKAMLEEQLTAARARGDKVHELEK----ENLQLKSKLHDLELDRDTDKKRIEELLEENM 416
+ +A + Q A + R + E + E L+ K + + + KK E+ L +
Sbjct: 2092 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK-QAADAEMEKHKKFAEQTLRQKA 2150
Query: 417 VLEIAQKQSMNESAHLGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQ 476
+E E L +LE+ +L D + E E A R ++E+E S++
Sbjct: 2151 QVE-------QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS-QVEEELFSVR 2202
Query: 477 STIQGLRDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLS---EE 533
++ L +E +K+N Q LQ + E+ KQ ++ LS +E
Sbjct: 2203 VQMEELSKLKARIEAENRALILRDKDNTQ-----RFLQEEAEKMKQVAEEAARLSVAAQE 2257
Query: 534 LIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENK 593
R ++ + D+ +A + +K+ M +++E +++ +EA + +KE
Sbjct: 2258 AARLRQLAEEDLAQQRALAEKMLKE----------KMQAVQEATRLKAEAELLQQQKEL- 2306
Query: 594 ALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQ-RLQEENGRLARKVT 652
A + +L+ +K Q+ + L + + +R + ER+ Q + E RL +V
Sbjct: 2307 --------AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2358
Query: 653 SLETATEKVE--ALEHESQGLQLENRTLRKSLDTLQNVSL-QLEGLERDNKQLDAENL-- 707
+ A + E A Q ++ + R L T + V+L Q ++R DAE L
Sbjct: 2359 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2418
Query: 708 ---ELRRLVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSV 764
EL R E ++ KL Q++ E Q ++++ L++ L ++ + + L + +
Sbjct: 2419 AIAELEREKEKLQ-QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI 2477
Query: 765 SAENLRLQQSLESSSHKTQTLESELG----ELEAERQALRRDLE-ALRLANAQLEGAEKD 819
E +L+Q + K Q L E ++E ERQ L +E A R + EG +
Sbjct: 2478 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2537
Query: 820 RKALEQEVAQLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARC 879
++ L+Q Q + ++LL +E +RL +Q++L + + A V A K L
Sbjct: 2538 QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNG 2597
Query: 880 RDAA-GKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSS--ELDKLSQELE 936
RDA G E E ++ + LR + ++L+ + S EL +L+Q
Sbjct: 2598 RDALDGPAAEAEPEH------------SFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2645
Query: 937 KVGLNRELLLQED-----DSGSDTKYKILEGRNE-----SALKTTLAMKEEKIVLLEAQ 985
V EL +ED S +L+ NE +AL+ L ++LLEAQ
Sbjct: 2646 TVD---ELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQ 2701
Score = 60.1 bits (144), Expect = 2e-08
Identities = 210/986 (21%), Positives = 366/986 (37%), Gaps = 189/986 (19%)
Query: 490 EESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSDMETLK 549
EE G + + L +LE +++ ++L+ + L+RE + +E+ +
Sbjct: 606 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 665
Query: 550 ADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQ---TVTEANGKL 606
A Q WS + EA +K EN A Q V EA G+L
Sbjct: 666 AALQTQ---------------WSWMLQLCCCIEAHLK----ENAAYFQFFSDVREAEGQL 706
Query: 607 SQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGRL-------------ARKVTS 653
+L+ R+ + + ++ +LE LQ Q+E +L A+ V
Sbjct: 707 QKLQEALRRKY-----SCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQ 761
Query: 654 LETAT-----------------EKVEALEHESQGLQLENRTLRKSLDTLQNVSLQL---- 692
L+ ++VE H+ QL L + +
Sbjct: 762 LKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPS 821
Query: 693 ---------EGLERDNKQLDAENLELRRLVETMRFTSTKLAQMERENQQLEREKEELRK- 742
+ + +L+A++ L L + L Q L R+ + +R
Sbjct: 822 VCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAW----QSLRRDVQLIRSW 877
Query: 743 NVDLLKALGKKSER-----LELSYQSVSAEN-----------LRLQQSLESSSHKTQTLE 786
++ + L + +R LEL YQ+ ++ L ++ S SH Q L
Sbjct: 878 SLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLL 937
Query: 787 SELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQ 846
L + E +R + L+ QLE E +L DK+ + A+R+ +
Sbjct: 938 QSLEQGAQEESRCQRCISELKDIRLQLEACE----TRTVHRLRLPLDKEPARECAQRIAE 993
Query: 847 QVELKDAV--LDDSTAKLSAVEKESRALDKELARCRDAAGKLK-ELEKDNRDLTKQVTVH 903
Q + + V L A+LSA ++ AL + AA L+ ELE LT
Sbjct: 994 QQKAQAEVEGLGKGVARLSAEAEKVLALPEP----SPAAPTLRSELE-----LTLGKLEQ 1044
Query: 904 ARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDS---------GSD 954
R+L+ + LEKLK+ L + + +Q E+V E L+E + +
Sbjct: 1045 VRSLSA----IYLEKLKTISL---VIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK 1097
Query: 955 TKYKILEGRNESALKTTLAMKEE-------KIVLLEAQMEEKASLNRQLESELQMLKKEC 1007
K L + E+ T A+++E L + E + R E Q+L++
Sbjct: 1098 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1157
Query: 1008 ETLRQ---NQGEGQHLQNSFKH------PAG---KTAASHQGK-EAWGPGHKEATMELLR 1054
L Q Q E + L ++ P G + A Q + +A +A E LR
Sbjct: 1158 AVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLR 1217
Query: 1055 VKDRAI-ELERNNAALQAEKQLLKEQLQHL---ETQNVTFSSQI--LTLQKQSAFLQEHN 1108
+ + E+ER+ ++ ++ K+ + + E Q VT+ +Q+ + + +Q +
Sbjct: 1218 QEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1277
Query: 1109 TTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETENESLQRQQ----EQLTAAY 1164
++ + L+ S L++ LT+QY + + E E L QQ + A
Sbjct: 1278 ESVIQEYVDLRTHYSELTT----LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1333
Query: 1165 EALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAELE 1224
EA L+ L H + A+ E K L + ++ E E D ++K ++
Sbjct: 1334 EAALEKQRQLAEAHAQAKAQAERE------AKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1387
Query: 1225 EREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQL----------KGEYEE 1274
E + L EA Q + A A E RLR E + + + QL +GE +
Sbjct: 1388 EELQQLRQSSEAEIQAKARQAEA-AERSRLRIE-EEIRVVRLQLEATERQRGGAEGELQA 1445
Query: 1275 LHAHTKELKTSLNNAQLELNRWQARFDELKEQHQTMDISLTKLDNHCELLSRLKGNLEEE 1334
L A +E + AQ E R + Q D S K EL SR+K E
Sbjct: 1446 LRARAEEAEAQKRQAQEEAERL---------RRQVQDESQRKRQAEVELASRVKAEAEAA 1496
Query: 1335 NH-----HLLSQIQLLSQQNQMLLEQ 1355
L +++L +++ + L Q
Sbjct: 1497 REKQRALQALEELRLQAEEAERRLRQ 1522
Score = 41.2 bits (95), Expect = 0.010
Identities = 95/403 (23%), Positives = 166/403 (41%), Gaps = 61/403 (15%)
Query: 519 REKQSNQDLETLSEELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQ 578
R S +++E L + ++ KE ++ +ADK R K + Q + +A + +
Sbjct: 274 RFPSSFEEIEILWSQFLKFKEM---ELPAKEADKNRS-KGIYQSLEGAVQA-----GQLK 324
Query: 579 VSSEARMKDVEKENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQ 638
V DVEKE LH + LE EK Q + + ER E L+R +
Sbjct: 325 VPPGYHPLDVEKEWGKLHVAI---------LEREK--------QLRSEFERLECLQRIVT 367
Query: 639 RLQEENGRLARKVTSLET-------------ATEKVEALEHESQGLQLENRTLRKSLDTL 685
+LQ E G ++ + ++ +E + R L + TL
Sbjct: 368 KLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTL 427
Query: 686 QN-VSLQLEGLERDNKQLDAENLELR-----RLVETMRFTSTKLAQMERENQQLEREKEE 739
++ Q E + R +L + +R RL + +T++AQ+ ++ Q E E+
Sbjct: 428 KDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELED 487
Query: 740 --LRKNVDLLKALGKKSERLE-----LSYQSVSAE---NLRLQQSLESSSHKTQTLESEL 789
LR DLL + + R++ + SV A+ + L QS+E K + S+
Sbjct: 488 STLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDE 547
Query: 790 GELE-AERQALRRDLEALRLANAQLEGAEKDR----KALEQEVAQLEKDKKLL-EKEAKR 843
G+L A R A R L L L A+L + K R ++L VA K+ L EKE +
Sbjct: 548 GQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEE 607
Query: 844 LWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKL 886
+ ++ + SA+ +E +K++ ++A +L
Sbjct: 608 VGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRL 650
Score = 39.7 bits (91), Expect = 0.030
Identities = 160/919 (17%), Positives = 365/919 (39%), Gaps = 102/919 (11%)
Query: 614 RQLHRDLEQAKEKGERAEKLERELQ-----RLQEENGRLARKVTS-LETATEKVEALEHE 667
R LH+ +E+ + K ERA E +L ++ GRL + L ++ ++ +LE
Sbjct: 527 RGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESL 586
Query: 668 SQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVETMRFTSTKLAQME 727
+ + L L+ + + + +R N + A+ L+ + K+ +++
Sbjct: 587 HSFVAAATKEL-MWLNEKEEEEVGFDWSDR-NTNMTAKKESYSALMRELELKEKKIKELQ 644
Query: 728 RENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSSHKTQTLES 787
+L RE R V+ +A + Q L+++ + E+
Sbjct: 645 NAGDRLLREDHPARPTVESFQA--ALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREA 702
Query: 788 ELGELEAERQALRRDLEALRLAN-AQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQ 846
E G+L+ ++ALRR R A +LE +D + E QL + K L AKR
Sbjct: 703 E-GQLQKLQEALRRKYSCDRSATVTRLEDLLQD---AQDEKEQLNEYKGHLSGLAKRAKA 758
Query: 847 QVELKD--------------AVLD----------------------------DSTAKLSA 864
V+LK AV D S+ +A
Sbjct: 759 VVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAA 818
Query: 865 VEKESRALDKELARCRDAAGKLKELEKDNRDLTKQVTVHARTL---TTLREDLVLEKLKS 921
V + ++A +L+ + L Q+ V ++L +LR D+ L ++S
Sbjct: 819 VPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQL--IRS 876
Query: 922 QQLSS----ELDKLSQELEKVGLNRELLLQ--EDDSGSDTKYKILEGRNESALKTTLAMK 975
L++ + ++ Q L + L+ + L+ +D G + +++ R +
Sbjct: 877 WSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHY--- 933
Query: 976 EEKIVLLEAQMEEKASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTA--- 1032
++ + LE +E++ R + SEL+ ++ + E L K PA + A
Sbjct: 934 QQLLQSLEQGAQEESRCQRCI-SELKDIRLQLEACETRTVHRLRLPLD-KEPARECAQRI 991
Query: 1033 ASHQGKEAWGPGHKEATMELLRVKDRAIELERNNAA---LQAEKQLLKEQLQHLETQNVT 1089
A Q +A G + L ++ + L + A L++E +L +L+ + + +
Sbjct: 992 AEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1051
Query: 1090 FSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETE 1149
+ ++ T+ Q L+ +L+ E + + L A L+ E +
Sbjct: 1052 YLEKLKTISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKASLKKLRAQAEAQ 1110
Query: 1150 NESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKEL 1209
+ +++L A E E L H + E E R+ L ++
Sbjct: 1111 QPTFDALRDELRGAQEV----GERLQQRHGERDVEVERW-RERVAQLLERWQAVLAQTDV 1165
Query: 1210 GERHGDMLKRKAEL--EEREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQ 1267
+R + L R+ E + + ++A +++++ A+ + ++Q +R +L + L +
Sbjct: 1166 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1225
Query: 1268 LK--GE-YEELHAHTKELKTSLNNAQLELNRWQARFDEL---KEQHQTMDISLTKLDNHC 1321
++ GE EE K+ ++ + +L+L ++A+ + + ++ + S + + +
Sbjct: 1226 IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYV 1285
Query: 1322 EL---LSRLKGNLEEENHHLLSQIQLLSQQNQMLLEQNMENKEQYHE-----EQKQYIDK 1373
+L S L + + ++ + ++ ++ +Q E +E+ E E+++ + +
Sbjct: 1286 DLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAE 1345
Query: 1374 LNALRRHKEKLEEKIMDQYKFYDPPPKKKNHWIGAKALVKLIKPKKEGSRERLKSTVDSP 1433
+A + + + E K + Q + + +++ + A+ + I+ + + R+ ++ + +
Sbjct: 1346 AHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1404
Query: 1434 PWQLESSDPASPAASQPLR 1452
Q E+++ + + +R
Sbjct: 1405 ARQAEAAERSRLRIEEEIR 1423
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 168 bits (426), Expect = 4e-41
Identities = 277/1208 (22%), Positives = 494/1208 (40%), Gaps = 127/1208 (10%)
Query: 252 LAVELAD--TKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSAR 309
+A+E A +A L+ R +KT QL + E V +L++ + Q A+A AR
Sbjct: 1702 VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1761
Query: 310 AYRD-ELDSLREKANRVERLELELTRCKEKLHDVDFYKARMEELREDNIILIETKAMLEE 368
+ EL+ + KAN RL L+ +E +A E+ +E+ + EE
Sbjct: 1762 EEAERELERWQLKANEALRLRLQ---AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEE 1818
Query: 369 QLTAARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIEELLEENMVLEIAQKQSMNE 428
Q A R R ELEK+ +L T ++R+ +E + L +Q +
Sbjct: 1819 Q--AVRQRELAEQELEKQR----------QLAEGTAQQRLAAE-QELIRLRAETEQGEQQ 1865
Query: 429 SAHLGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASLV 488
L EL +L + A + R+ EL + + + L + ++ + + +
Sbjct: 1866 RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1925
Query: 489 LEESGLKCGELEKENHQLSKKIE--KLQTQLEREKQSNQDLETLSEELIREKEQLQSDME 546
LE + EL +E +L E K Q QL E + Q E +E ++ EK +
Sbjct: 1926 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE--AERVLAEKLAAIGEAT 1983
Query: 547 TLKADKARQIKDLEQEKDHLNRAMWS---LRERSQVSSEARMKDVEKE----NKALHQTV 599
LK + +K+ E E + L R R R + + D+E+ KA +
Sbjct: 1984 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 2043
Query: 600 TEANGKLSQLEFEKRQLHRDLEQAKEKGERAE----KLERELQRLQE--ENGRLARKVTS 653
G + ++RQ+ ++ K E+A +LE EL R++ E+ +++
Sbjct: 2044 ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 2103
Query: 654 LETATEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLV 713
LE A ++ A E E + + E R ++KSL + + Q + + ++L A+ E RRL
Sbjct: 2104 LEAARQRQLAAEEERRRREAEER-VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLR 2162
Query: 714 ETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQ 773
E S + Q+ +E Q + EE A+ +K + L+ + Q + +L+
Sbjct: 2163 ERAEQESARQLQLAQEAAQKRLQAEEKAHAF----AVQQKEQELQQTLQQEQSVLDQLRG 2218
Query: 774 SLESSSHKTQTLESELGELEAERQAL--RRDLEALRLANAQLEGAEKDRKALEQEVAQLE 831
E++ + E+E ++AER+A RR +E A + AE+ +A Q A E
Sbjct: 2219 EAEAARRAAE--EAEEARVQAEREAAQSRRQVEE---AERLKQSAEEQAQARAQAQAAAE 2273
Query: 832 KDKKLLEKEAKRLWQ-------QVELKDAVLDDSTAKLSAVEKESRALDKELARCR---- 880
K +K E+EA R Q Q + DA ++ ++ +++EL R
Sbjct: 2274 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2333
Query: 881 DAAGKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGL 940
+ + L+++ + L + T AR + + E+L +++ ++LS ++ E
Sbjct: 2334 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE------ 2387
Query: 941 NRELLLQEDDSGS----DTKYKILEGRNESALKTTLAMK--------EEKIVLLEAQMEE 988
NR L+L++ D+ + K+ + E+A + A + EE + A E+
Sbjct: 2388 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEK 2447
Query: 989 KASLNRQLESELQMLKKECETLRQN----QGEGQHLQNSFKHPAGKTAASHQG----KEA 1040
Q E LK E E L+Q Q + + LQ + A + A QG EA
Sbjct: 2448 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2507
Query: 1041 WGPGHKEATMELLRVKDRAIELERNNAALQAEKQLLKEQLQH---------LETQNVTFS 1091
E + E R+K R E+ R A + + Q ++Q + L TQ
Sbjct: 2508 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2567
Query: 1092 SQILTLQKQSAF-----LQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAK 1146
Q L +Q+Q + L+E L+ + KLQ E L +S + +Q +
Sbjct: 2568 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQT----VQQEQLLQ 2623
Query: 1147 ETE--NESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLEL 1204
ET+ +S +++ L + Q+ L L + + A+ + L + + + +E
Sbjct: 2624 ETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ---QRQQQQMEQ 2680
Query: 1205 EHKELGERHGDMLKRKAELEEREKVLTTEREALQQEQRTNA-LAMGENQRLRGELDRVNF 1263
E + L + +R+ E EE + E + L+Q++R L ENQRLR +L +
Sbjct: 2681 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEE 2740
Query: 1264 LHHQLKGEYEELHAHTKELKTSLNNAQLELNRWQAR------FDELKEQHQTMDISLTKL 1317
H EE+ A +L N + L+ A FD L+ + + +
Sbjct: 2741 QHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGI 2800
Query: 1318 DNHCELLSRLKGNL--------EEENHHLLSQIQLLSQQNQMLLEQNMENKEQYHEEQKQ 1369
+ EL +G+ E+ H+L + + +LL+ E Y Q+Q
Sbjct: 2801 LSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAG----LLLKATNEKLSVYAALQRQ 2856
Query: 1370 YIDKLNAL 1377
+ AL
Sbjct: 2857 LLSPGTAL 2864
Score = 158 bits (399), Expect = 6e-38
Identities = 294/1385 (21%), Positives = 558/1385 (40%), Gaps = 161/1385 (11%)
Query: 176 ELPDVAPEELEALSRSMVLHLRRLIDQRD--ECTELIVDLTQERDYLQAQHPPSPIKSSS 233
EL D+ + LEA V LR +D+ EC + I + Q++ + + + S
Sbjct: 1125 ELKDIRLQ-LEACETRTVHRLRLPLDKEPARECAQRIAE--QQKAQAEVEGLGKGVARLS 1181
Query: 234 ADSTPSPTSSLSSEDKQHLAVELADTKARLRRVR-----------------------QEL 270
A++ S L EL T +L +VR +E+
Sbjct: 1182 AEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEV 1241
Query: 271 EDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSAR----AYRDELDSLREKANRVE 326
E+ + V + EL+ K +L A A + + A RDEL +E R++
Sbjct: 1242 LRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQ 1301
Query: 327 RL----ELELTRCKEK-----------LHDVDFYKARMEELREDNIILIETKAMLEEQLT 371
+ ++E+ R +E+ L D + +E+L E+ L L
Sbjct: 1302 QRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQ 1361
Query: 372 AARARGDKVHELEKENLQ-LKSKLHDLELDRDTDKKRIEELLEENMVLEIAQ---KQSMN 427
AR R +++ + + Q ++ +L ++ +EE+ +E Q KQ +N
Sbjct: 1362 DARRRQEQIQAMPLADSQAVREQLRQ-------EQALLEEIERHGEKVEECQRFAKQYIN 1414
Query: 428 ESAHLGWELEQLSKNADL---SDASRKSFVFELNECASSRILKLEKENQSLQS-TIQGLR 483
A +EL+ ++ A L + ++K V +E + L L + T Q ++
Sbjct: 1415 --AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK 1472
Query: 484 DASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQS 543
S L + E++ + +++ +++ LE+++Q + + RE ++LQ
Sbjct: 1473 FISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1532
Query: 544 DMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKA--------- 594
M+ + D +Q+K + + LR+ S+ +A+ + E ++
Sbjct: 1533 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1592
Query: 595 ---LHQTVTE-----ANGKLSQLEFEKRQLHRDLEQAKEKGERAEK-LERELQRLQEENG 645
L TE A G+L L + QA+E+ ER + ++ E QR ++
Sbjct: 1593 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1652
Query: 646 RLARKV-TSLETATEKVEAL----EHESQGLQLENRTLRKSLDTLQNVSLQLEGLERD-- 698
LA +V E A EK AL E Q + E R + ++ + V + LE +R
Sbjct: 1653 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1712
Query: 699 -----------------NKQLDAENLELRRLVETMRFTSTKLAQMERENQQLEREKE--E 739
+ L E++ + +L E + + A+ ER ++ ERE E +
Sbjct: 1713 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1772
Query: 740 LRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLES----SSHKTQTLESELGELEAE 795
L+ N L L + + S AE + + E+ + + + EL E E E
Sbjct: 1773 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1832
Query: 796 R----------QALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLW 845
+ Q L + E +RL A+ E E+ R+ LE+E+A+L+++ ++ + L
Sbjct: 1833 KQRQLAEGTAQQRLAAEQELIRL-RAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1891
Query: 846 QQVELKDAVLDDSTAKLSAVEKESRAL-DKELARCRDAAGKLKELEKDNRDLTKQVTVHA 904
++ A ++ A + E+ESR+ +K R AG+ +EL ++ L
Sbjct: 1892 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1951
Query: 905 RTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSDTKYKILEGRN 964
R ED ++ +++++ +E E ++ E+ L+E ++ ++ ++ E +
Sbjct: 1952 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE--D 2009
Query: 965 ESALKTTLAMKEEKIVLLEAQMEEK-ASLNRQLESELQMLKKECE-TLRQN---QGEGQH 1019
E+ + L EE+ +A +EE+ A L + +SEL+ K E TLRQ + E
Sbjct: 2010 EAFQRRRL---EEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA 2066
Query: 1020 LQNSF-KHPAGKTAAS------HQGKEAWGPGHKEATMELLRVKDRAIELE--RNNAALQ 1070
L+ SF K AGK E ++A +E R + A E E R A +
Sbjct: 2067 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 2126
Query: 1071 AEKQLLKEQLQHLETQNVTFSSQILTLQKQSA----FLQEHNTTLQTQTAKLQVENSTLS 1126
+K L E+ + + + L + + A E + Q Q A+ + +
Sbjct: 2127 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2186
Query: 1127 SQSAALTAQYTLLQNHHTAKETENESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYE 1186
+ A A Q + E L + + + AA A ++ E ER++A+
Sbjct: 2187 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA-AEEAEEARVQAEREAAQSR 2245
Query: 1187 ALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAELEEREKVLTTEREALQQEQRTNAL 1246
+ + LK + + + + + L+++AE +E + E+ AL+Q+Q +A
Sbjct: 2246 RQVEEAERLKQSAEE-QAQARAQAQAAAEKLRKEAE-QEAARRAQAEQAALRQKQAADA- 2302
Query: 1247 AMGENQRLRGELDRVNFLHHQLKGEYEELHAHTKELKTSLNNAQLELNRWQARFDELKEQ 1306
E ++ + ++ Q++ E L +E N EL R +A E Q
Sbjct: 2303 ---EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2359
Query: 1307 HQTMDISLTKLDNHCELLSRLKGNLEEENHHLLSQIQLLSQQNQMLLEQNMENKEQYHEE 1366
++ L + E LS+LK +E EN L+ + + Q L++ E +Q EE
Sbjct: 2360 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK---DNTQRFLQEEAEKMKQVAEE 2416
Query: 1367 QKQYIDKLNALRRHKEKLEEKIMDQYKFYDPPPKKKNHWI----GAKALVKLIKPKKEGS 1422
+ R ++ EE + Q + K+K + KA +L++ +KE +
Sbjct: 2417 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA 2476
Query: 1423 RERLK 1427
+E+ +
Sbjct: 2477 QEQAR 2481
Score = 119 bits (299), Expect = 2e-26
Identities = 167/790 (21%), Positives = 355/790 (44%), Gaps = 131/790 (16%)
Query: 249 KQHLAVELADTKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSA 308
++ A AD + RL ++R+ + + E+ + V+ + + ++V++E + L A A
Sbjct: 2018 EEQAAQHKADIEERLAQLRKASDSELER---QKGLVEDTLRQRRQVEEEILALKASFEKA 2074
Query: 309 RAYRDEL------------DSLREKANRVERLELELTRCKEKLHDVDFYKARMEELREDN 356
A + EL D+LR K E+ ELE R ++ + + + EE + +
Sbjct: 2075 AAGKAELELELGRIRSNAEDTLRSK----EQAELEAARQRQLAAEEERRRREAEERVQKS 2130
Query: 357 IILIET-----KAMLEEQLTAARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIE-- 409
+ E KA LEE + +A+ ++ L + Q ++ L+L ++ +KR++
Sbjct: 2131 LAAEEEAARQRKAALEE-VERLKAKVEEARRLRERAEQESAR--QLQLAQEAAQKRLQAE 2187
Query: 410 --------ELLEENMVLEIAQKQSMNESAHLGWELEQLSKNADLSDASRKSFVFELNECA 461
+ E+ + + Q+QS+ + L E E + A+ ++ +R V E A
Sbjct: 2188 EKAHAFAVQQKEQELQQTLQQEQSVLDQ--LRGEAEAARRAAEEAEEAR---VQAEREAA 2242
Query: 462 SSR--ILKLEKENQSLQSTIQGLRDASLVLEESGLKCGELEKENHQ-LSKKIEKLQTQLE 518
SR + + E+ QS + Q A E+ L KE Q +++ + Q L
Sbjct: 2243 QSRRQVEEAERLKQSAEEQAQARAQAQAAAEK-------LRKEAEQEAARRAQAEQAALR 2295
Query: 519 REKQSNQDLET---LSEELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSL-- 573
+++ ++ ++E +E+ +R+K Q++ ++ TL+ Q+++ + +K+ L+ + L
Sbjct: 2296 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL----QLEETDHQKNLLDEELQRLKA 2351
Query: 574 ------RERSQVSSEARMKDVEKENKALHQTVTEANGK---LSQLEFEKRQLHRDLEQAK 624
R+RSQV E V+ E + + EA + L + +R L + E+ K
Sbjct: 2352 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2411
Query: 625 EKGERAEKLE------RELQRLQEEN---------GRLARKVTSLETATE---KVEALEH 666
+ E A +L L++L EE+ L K+ +++ AT + E L+
Sbjct: 2412 QVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2471
Query: 667 ESQGLQLENRTLRKSLDTL-QNVSLQLEGLERDNKQLDAENLELRRLVETMRFTSTKLAQ 725
+ + Q + R L++ + + Q ++ + +G +R + LE+ E ++ ++A+
Sbjct: 2472 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL---RVAE 2528
Query: 726 MERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLE----SSSHK 781
M R + E + + RK + +G+K R EL+ Q E + L Q+LE S H
Sbjct: 2529 MSRAQARAEEDAQRFRKQAE---EIGEKLHRTELATQ----EKVTLVQTLEIQRQQSDHD 2581
Query: 782 TQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQ---LEKDKKLLE 838
+ L + ELE E++ L+++ + L+L + +++ ++++ E + Q L + LL+
Sbjct: 2582 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2641
Query: 839 KEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDNRDLTK 898
+E +E+E L++ +D K ++L ++ + +
Sbjct: 2642 RE----------------------RFIEQEKAKLEQLF---QDEVAKAQQLREEQQRQQQ 2676
Query: 899 QVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSDTKYK 958
Q+ + L E+ + ++++ + Q+LE+ +E LL E++ + +
Sbjct: 2677 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2736
Query: 959 ILEGRNESAL 968
+LE ++ +AL
Sbjct: 2737 LLEEQHRAAL 2746
Score = 115 bits (289), Expect = 3e-25
Identities = 180/779 (23%), Positives = 323/779 (41%), Gaps = 104/779 (13%)
Query: 247 EDKQHLAVELADTKARLRRVRQELEDKTEQLVDTRHE--VDQLVLELQKVKQENI----Q 300
E+ + L AR ++ QE K Q + H V Q ELQ+ Q+ Q
Sbjct: 2156 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2215
Query: 301 LAADARSARAYRDELDSLREKANRVERLELELTRCKEKLHDVDFYKARMEELREDNIILI 360
L +A +AR +E + R +A R E + + ++ + + K EE
Sbjct: 2216 LRGEAEAARRAAEEAEEARVQAER------EAAQSRRQVEEAERLKQSAEE--------- 2260
Query: 361 ETKAMLEEQLTAARARGDKVHELEK----ENLQLKSKLHDLELDRDTDKKRIEELLEENM 416
+ +A + Q A + R + E + E L+ K + + + KK E+ L +
Sbjct: 2261 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK-QAADAEMEKHKKFAEQTLRQKA 2319
Query: 417 VLEIAQKQSMNESAHLGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQ 476
+E E L +LE+ +L D + E E A R ++E+E S++
Sbjct: 2320 QVE-------QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS-QVEEELFSVR 2371
Query: 477 STIQGLRDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLS---EE 533
++ L +E +K+N Q LQ + E+ KQ ++ LS +E
Sbjct: 2372 VQMEELSKLKARIEAENRALILRDKDNTQ-----RFLQEEAEKMKQVAEEAARLSVAAQE 2426
Query: 534 LIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENK 593
R ++ + D+ +A + +K+ M +++E +++ +EA + +KE
Sbjct: 2427 AARLRQLAEEDLAQQRALAEKMLKE----------KMQAVQEATRLKAEAELLQQQKEL- 2475
Query: 594 ALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQ-RLQEENGRLARKVT 652
A + +L+ +K Q+ + L + + +R + ER+ Q + E RL +V
Sbjct: 2476 --------AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2527
Query: 653 SLETATEKVE--ALEHESQGLQLENRTLRKSLDTLQNVSL-QLEGLERDNKQLDAENL-- 707
+ A + E A Q ++ + R L T + V+L Q ++R DAE L
Sbjct: 2528 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2587
Query: 708 ---ELRRLVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSV 764
EL R E ++ KL Q++ E Q ++++ L++ L ++ + + L + +
Sbjct: 2588 AIAELEREKEKLQ-QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI 2646
Query: 765 SAENLRLQQSLESSSHKTQTLESELG----ELEAERQALRRDLE-ALRLANAQLEGAEKD 819
E +L+Q + K Q L E ++E ERQ L +E A R + EG +
Sbjct: 2647 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2706
Query: 820 RKALEQEVAQLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARC 879
++ L+Q Q + ++LL +E +RL +Q++L + + A V A K L
Sbjct: 2707 QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNG 2766
Query: 880 RDAA-GKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSS--ELDKLSQELE 936
RDA G E E ++ + LR + ++L+ + S EL +L+Q
Sbjct: 2767 RDALDGPAAEAEPEH------------SFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2814
Query: 937 KVGLNRELLLQED-----DSGSDTKYKILEGRNE-----SALKTTLAMKEEKIVLLEAQ 985
V EL +ED S +L+ NE +AL+ L ++LLEAQ
Sbjct: 2815 TVD---ELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQ 2870
Score = 60.1 bits (144), Expect = 2e-08
Identities = 210/986 (21%), Positives = 366/986 (37%), Gaps = 189/986 (19%)
Query: 490 EESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSDMETLK 549
EE G + + L +LE +++ ++L+ + L+RE + +E+ +
Sbjct: 775 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 834
Query: 550 ADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQ---TVTEANGKL 606
A Q WS + EA +K EN A Q V EA G+L
Sbjct: 835 AALQTQ---------------WSWMLQLCCCIEAHLK----ENAAYFQFFSDVREAEGQL 875
Query: 607 SQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGRL-------------ARKVTS 653
+L+ R+ + + ++ +LE LQ Q+E +L A+ V
Sbjct: 876 QKLQEALRRKY-----SCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQ 930
Query: 654 LETAT-----------------EKVEALEHESQGLQLENRTLRKSLDTLQNVSLQL---- 692
L+ ++VE H+ QL L + +
Sbjct: 931 LKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPS 990
Query: 693 ---------EGLERDNKQLDAENLELRRLVETMRFTSTKLAQMERENQQLEREKEELRK- 742
+ + +L+A++ L L + L Q L R+ + +R
Sbjct: 991 VCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAW----QSLRRDVQLIRSW 1046
Query: 743 NVDLLKALGKKSER-----LELSYQSVSAEN-----------LRLQQSLESSSHKTQTLE 786
++ + L + +R LEL YQ+ ++ L ++ S SH Q L
Sbjct: 1047 SLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLL 1106
Query: 787 SELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQ 846
L + E +R + L+ QLE E +L DK+ + A+R+ +
Sbjct: 1107 QSLEQGAQEESRCQRCISELKDIRLQLEACE----TRTVHRLRLPLDKEPARECAQRIAE 1162
Query: 847 QVELKDAV--LDDSTAKLSAVEKESRALDKELARCRDAAGKLK-ELEKDNRDLTKQVTVH 903
Q + + V L A+LSA ++ AL + AA L+ ELE LT
Sbjct: 1163 QQKAQAEVEGLGKGVARLSAEAEKVLALPEP----SPAAPTLRSELE-----LTLGKLEQ 1213
Query: 904 ARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDS---------GSD 954
R+L+ + LEKLK+ L + + +Q E+V E L+E + +
Sbjct: 1214 VRSLSA----IYLEKLKTISL---VIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK 1266
Query: 955 TKYKILEGRNESALKTTLAMKEE-------KIVLLEAQMEEKASLNRQLESELQMLKKEC 1007
K L + E+ T A+++E L + E + R E Q+L++
Sbjct: 1267 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1326
Query: 1008 ETLRQ---NQGEGQHLQNSFKH------PAG---KTAASHQGK-EAWGPGHKEATMELLR 1054
L Q Q E + L ++ P G + A Q + +A +A E LR
Sbjct: 1327 AVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLR 1386
Query: 1055 VKDRAI-ELERNNAALQAEKQLLKEQLQHL---ETQNVTFSSQI--LTLQKQSAFLQEHN 1108
+ + E+ER+ ++ ++ K+ + + E Q VT+ +Q+ + + +Q +
Sbjct: 1387 QEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1446
Query: 1109 TTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETENESLQRQQ----EQLTAAY 1164
++ + L+ S L++ LT+QY + + E E L QQ + A
Sbjct: 1447 ESVIQEYVDLRTHYSELTT----LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1502
Query: 1165 EALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAELE 1224
EA L+ L H + A+ E K L + ++ E E D ++K ++
Sbjct: 1503 EAALEKQRQLAEAHAQAKAQAERE------AKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1556
Query: 1225 EREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQL----------KGEYEE 1274
E + L EA Q + A A E RLR E + + + QL +GE +
Sbjct: 1557 EELQQLRQSSEAEIQAKARQAEA-AERSRLRIE-EEIRVVRLQLEATERQRGGAEGELQA 1614
Query: 1275 LHAHTKELKTSLNNAQLELNRWQARFDELKEQHQTMDISLTKLDNHCELLSRLKGNLEEE 1334
L A +E + AQ E R + Q D S K EL SR+K E
Sbjct: 1615 LRARAEEAEAQKRQAQEEAERL---------RRQVQDESQRKRQAEVELASRVKAEAEAA 1665
Query: 1335 NH-----HLLSQIQLLSQQNQMLLEQ 1355
L +++L +++ + L Q
Sbjct: 1666 REKQRALQALEELRLQAEEAERRLRQ 1691
Score = 41.2 bits (95), Expect = 0.010
Identities = 95/403 (23%), Positives = 166/403 (41%), Gaps = 61/403 (15%)
Query: 519 REKQSNQDLETLSEELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQ 578
R S +++E L + ++ KE ++ +ADK R K + Q + +A + +
Sbjct: 443 RFPSSFEEIEILWSQFLKFKEM---ELPAKEADKNRS-KGIYQSLEGAVQA-----GQLK 493
Query: 579 VSSEARMKDVEKENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQ 638
V DVEKE LH + LE EK Q + + ER E L+R +
Sbjct: 494 VPPGYHPLDVEKEWGKLHVAI---------LEREK--------QLRSEFERLECLQRIVT 536
Query: 639 RLQEENGRLARKVTSLET-------------ATEKVEALEHESQGLQLENRTLRKSLDTL 685
+LQ E G ++ + ++ +E + R L + TL
Sbjct: 537 KLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTL 596
Query: 686 QN-VSLQLEGLERDNKQLDAENLELR-----RLVETMRFTSTKLAQMERENQQLEREKEE 739
++ Q E + R +L + +R RL + +T++AQ+ ++ Q E E+
Sbjct: 597 KDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELED 656
Query: 740 --LRKNVDLLKALGKKSERLE-----LSYQSVSAE---NLRLQQSLESSSHKTQTLESEL 789
LR DLL + + R++ + SV A+ + L QS+E K + S+
Sbjct: 657 STLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDE 716
Query: 790 GELE-AERQALRRDLEALRLANAQLEGAEKDR----KALEQEVAQLEKDKKLL-EKEAKR 843
G+L A R A R L L L A+L + K R ++L VA K+ L EKE +
Sbjct: 717 GQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEE 776
Query: 844 LWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKL 886
+ ++ + SA+ +E +K++ ++A +L
Sbjct: 777 VGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRL 819
Score = 39.7 bits (91), Expect = 0.030
Identities = 160/919 (17%), Positives = 365/919 (39%), Gaps = 102/919 (11%)
Query: 614 RQLHRDLEQAKEKGERAEKLERELQ-----RLQEENGRLARKVTS-LETATEKVEALEHE 667
R LH+ +E+ + K ERA E +L ++ GRL + L ++ ++ +LE
Sbjct: 696 RGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESL 755
Query: 668 SQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVETMRFTSTKLAQME 727
+ + L L+ + + + +R N + A+ L+ + K+ +++
Sbjct: 756 HSFVAAATKEL-MWLNEKEEEEVGFDWSDR-NTNMTAKKESYSALMRELELKEKKIKELQ 813
Query: 728 RENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSSHKTQTLES 787
+L RE R V+ +A + Q L+++ + E+
Sbjct: 814 NAGDRLLREDHPARPTVESFQA--ALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREA 871
Query: 788 ELGELEAERQALRRDLEALRLAN-AQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQ 846
E G+L+ ++ALRR R A +LE +D + E QL + K L AKR
Sbjct: 872 E-GQLQKLQEALRRKYSCDRSATVTRLEDLLQD---AQDEKEQLNEYKGHLSGLAKRAKA 927
Query: 847 QVELKD--------------AVLD----------------------------DSTAKLSA 864
V+LK AV D S+ +A
Sbjct: 928 VVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAA 987
Query: 865 VEKESRALDKELARCRDAAGKLKELEKDNRDLTKQVTVHARTL---TTLREDLVLEKLKS 921
V + ++A +L+ + L Q+ V ++L +LR D+ L ++S
Sbjct: 988 VPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQL--IRS 1045
Query: 922 QQLSS----ELDKLSQELEKVGLNRELLLQ--EDDSGSDTKYKILEGRNESALKTTLAMK 975
L++ + ++ Q L + L+ + L+ +D G + +++ R +
Sbjct: 1046 WSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHY--- 1102
Query: 976 EEKIVLLEAQMEEKASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTA--- 1032
++ + LE +E++ R + SEL+ ++ + E L K PA + A
Sbjct: 1103 QQLLQSLEQGAQEESRCQRCI-SELKDIRLQLEACETRTVHRLRLPLD-KEPARECAQRI 1160
Query: 1033 ASHQGKEAWGPGHKEATMELLRVKDRAIELERNNAA---LQAEKQLLKEQLQHLETQNVT 1089
A Q +A G + L ++ + L + A L++E +L +L+ + + +
Sbjct: 1161 AEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1220
Query: 1090 FSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETE 1149
+ ++ T+ Q L+ +L+ E + + L A L+ E +
Sbjct: 1221 YLEKLKTISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKASLKKLRAQAEAQ 1279
Query: 1150 NESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKEL 1209
+ +++L A E E L H + E E R+ L ++
Sbjct: 1280 QPTFDALRDELRGAQEV----GERLQQRHGERDVEVERW-RERVAQLLERWQAVLAQTDV 1334
Query: 1210 GERHGDMLKRKAEL--EEREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQ 1267
+R + L R+ E + + ++A +++++ A+ + ++Q +R +L + L +
Sbjct: 1335 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1394
Query: 1268 LK--GE-YEELHAHTKELKTSLNNAQLELNRWQARFDEL---KEQHQTMDISLTKLDNHC 1321
++ GE EE K+ ++ + +L+L ++A+ + + ++ + S + + +
Sbjct: 1395 IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYV 1454
Query: 1322 EL---LSRLKGNLEEENHHLLSQIQLLSQQNQMLLEQNMENKEQYHE-----EQKQYIDK 1373
+L S L + + ++ + ++ ++ +Q E +E+ E E+++ + +
Sbjct: 1455 DLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAE 1514
Query: 1374 LNALRRHKEKLEEKIMDQYKFYDPPPKKKNHWIGAKALVKLIKPKKEGSRERLKSTVDSP 1433
+A + + + E K + Q + + +++ + A+ + I+ + + R+ ++ + +
Sbjct: 1515 AHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1573
Query: 1434 PWQLESSDPASPAASQPLR 1452
Q E+++ + + +R
Sbjct: 1574 ARQAEAAERSRLRIEEEIR 1592
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 168 bits (426), Expect = 4e-41
Identities = 277/1208 (22%), Positives = 494/1208 (40%), Gaps = 127/1208 (10%)
Query: 252 LAVELAD--TKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSAR 309
+A+E A +A L+ R +KT QL + E V +L++ + Q A+A AR
Sbjct: 1543 VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1602
Query: 310 AYRD-ELDSLREKANRVERLELELTRCKEKLHDVDFYKARMEELREDNIILIETKAMLEE 368
+ EL+ + KAN RL L+ +E +A E+ +E+ + EE
Sbjct: 1603 EEAERELERWQLKANEALRLRLQ---AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEE 1659
Query: 369 QLTAARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIEELLEENMVLEIAQKQSMNE 428
Q A R R ELEK+ +L T ++R+ +E + L +Q +
Sbjct: 1660 Q--AVRQRELAEQELEKQR----------QLAEGTAQQRLAAE-QELIRLRAETEQGEQQ 1706
Query: 429 SAHLGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASLV 488
L EL +L + A + R+ EL + + + L + ++ + + +
Sbjct: 1707 RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1766
Query: 489 LEESGLKCGELEKENHQLSKKIE--KLQTQLEREKQSNQDLETLSEELIREKEQLQSDME 546
LE + EL +E +L E K Q QL E + Q E +E ++ EK +
Sbjct: 1767 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE--AERVLAEKLAAIGEAT 1824
Query: 547 TLKADKARQIKDLEQEKDHLNRAMWS---LRERSQVSSEARMKDVEKE----NKALHQTV 599
LK + +K+ E E + L R R R + + D+E+ KA +
Sbjct: 1825 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1884
Query: 600 TEANGKLSQLEFEKRQLHRDLEQAKEKGERAE----KLERELQRLQE--ENGRLARKVTS 653
G + ++RQ+ ++ K E+A +LE EL R++ E+ +++
Sbjct: 1885 ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 1944
Query: 654 LETATEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLV 713
LE A ++ A E E + + E R ++KSL + + Q + + ++L A+ E RRL
Sbjct: 1945 LEAARQRQLAAEEERRRREAEER-VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLR 2003
Query: 714 ETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQ 773
E S + Q+ +E Q + EE A+ +K + L+ + Q + +L+
Sbjct: 2004 ERAEQESARQLQLAQEAAQKRLQAEEKAHAF----AVQQKEQELQQTLQQEQSVLDQLRG 2059
Query: 774 SLESSSHKTQTLESELGELEAERQAL--RRDLEALRLANAQLEGAEKDRKALEQEVAQLE 831
E++ + E+E ++AER+A RR +E A + AE+ +A Q A E
Sbjct: 2060 EAEAARRAAE--EAEEARVQAEREAAQSRRQVEE---AERLKQSAEEQAQARAQAQAAAE 2114
Query: 832 KDKKLLEKEAKRLWQ-------QVELKDAVLDDSTAKLSAVEKESRALDKELARCR---- 880
K +K E+EA R Q Q + DA ++ ++ +++EL R
Sbjct: 2115 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2174
Query: 881 DAAGKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGL 940
+ + L+++ + L + T AR + + E+L +++ ++LS ++ E
Sbjct: 2175 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE------ 2228
Query: 941 NRELLLQEDDSGS----DTKYKILEGRNESALKTTLAMK--------EEKIVLLEAQMEE 988
NR L+L++ D+ + K+ + E+A + A + EE + A E+
Sbjct: 2229 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEK 2288
Query: 989 KASLNRQLESELQMLKKECETLRQN----QGEGQHLQNSFKHPAGKTAASHQG----KEA 1040
Q E LK E E L+Q Q + + LQ + A + A QG EA
Sbjct: 2289 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2348
Query: 1041 WGPGHKEATMELLRVKDRAIELERNNAALQAEKQLLKEQLQH---------LETQNVTFS 1091
E + E R+K R E+ R A + + Q ++Q + L TQ
Sbjct: 2349 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2408
Query: 1092 SQILTLQKQSAF-----LQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAK 1146
Q L +Q+Q + L+E L+ + KLQ E L +S + +Q +
Sbjct: 2409 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQT----VQQEQLLQ 2464
Query: 1147 ETE--NESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLEL 1204
ET+ +S +++ L + Q+ L L + + A+ + L + + + +E
Sbjct: 2465 ETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ---QRQQQQMEQ 2521
Query: 1205 EHKELGERHGDMLKRKAELEEREKVLTTEREALQQEQRTNA-LAMGENQRLRGELDRVNF 1263
E + L + +R+ E EE + E + L+Q++R L ENQRLR +L +
Sbjct: 2522 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEE 2581
Query: 1264 LHHQLKGEYEELHAHTKELKTSLNNAQLELNRWQAR------FDELKEQHQTMDISLTKL 1317
H EE+ A +L N + L+ A FD L+ + + +
Sbjct: 2582 QHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGI 2641
Query: 1318 DNHCELLSRLKGNL--------EEENHHLLSQIQLLSQQNQMLLEQNMENKEQYHEEQKQ 1369
+ EL +G+ E+ H+L + + +LL+ E Y Q+Q
Sbjct: 2642 LSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAG----LLLKATNEKLSVYAALQRQ 2697
Query: 1370 YIDKLNAL 1377
+ AL
Sbjct: 2698 LLSPGTAL 2705
Score = 158 bits (399), Expect = 6e-38
Identities = 294/1385 (21%), Positives = 558/1385 (40%), Gaps = 161/1385 (11%)
Query: 176 ELPDVAPEELEALSRSMVLHLRRLIDQRD--ECTELIVDLTQERDYLQAQHPPSPIKSSS 233
EL D+ + LEA V LR +D+ EC + I + Q++ + + + S
Sbjct: 966 ELKDIRLQ-LEACETRTVHRLRLPLDKEPARECAQRIAE--QQKAQAEVEGLGKGVARLS 1022
Query: 234 ADSTPSPTSSLSSEDKQHLAVELADTKARLRRVR-----------------------QEL 270
A++ S L EL T +L +VR +E+
Sbjct: 1023 AEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEV 1082
Query: 271 EDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSAR----AYRDELDSLREKANRVE 326
E+ + V + EL+ K +L A A + + A RDEL +E R++
Sbjct: 1083 LRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQ 1142
Query: 327 RL----ELELTRCKEK-----------LHDVDFYKARMEELREDNIILIETKAMLEEQLT 371
+ ++E+ R +E+ L D + +E+L E+ L L
Sbjct: 1143 QRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQ 1202
Query: 372 AARARGDKVHELEKENLQ-LKSKLHDLELDRDTDKKRIEELLEENMVLEIAQ---KQSMN 427
AR R +++ + + Q ++ +L ++ +EE+ +E Q KQ +N
Sbjct: 1203 DARRRQEQIQAMPLADSQAVREQLRQ-------EQALLEEIERHGEKVEECQRFAKQYIN 1255
Query: 428 ESAHLGWELEQLSKNADL---SDASRKSFVFELNECASSRILKLEKENQSLQS-TIQGLR 483
A +EL+ ++ A L + ++K V +E + L L + T Q ++
Sbjct: 1256 --AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK 1313
Query: 484 DASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQS 543
S L + E++ + +++ +++ LE+++Q + + RE ++LQ
Sbjct: 1314 FISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1373
Query: 544 DMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKA--------- 594
M+ + D +Q+K + + LR+ S+ +A+ + E ++
Sbjct: 1374 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1433
Query: 595 ---LHQTVTE-----ANGKLSQLEFEKRQLHRDLEQAKEKGERAEK-LERELQRLQEENG 645
L TE A G+L L + QA+E+ ER + ++ E QR ++
Sbjct: 1434 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1493
Query: 646 RLARKV-TSLETATEKVEAL----EHESQGLQLENRTLRKSLDTLQNVSLQLEGLERD-- 698
LA +V E A EK AL E Q + E R + ++ + V + LE +R
Sbjct: 1494 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1553
Query: 699 -----------------NKQLDAENLELRRLVETMRFTSTKLAQMERENQQLEREKE--E 739
+ L E++ + +L E + + A+ ER ++ ERE E +
Sbjct: 1554 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1613
Query: 740 LRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLES----SSHKTQTLESELGELEAE 795
L+ N L L + + S AE + + E+ + + + EL E E E
Sbjct: 1614 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1673
Query: 796 R----------QALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLW 845
+ Q L + E +RL A+ E E+ R+ LE+E+A+L+++ ++ + L
Sbjct: 1674 KQRQLAEGTAQQRLAAEQELIRL-RAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1732
Query: 846 QQVELKDAVLDDSTAKLSAVEKESRAL-DKELARCRDAAGKLKELEKDNRDLTKQVTVHA 904
++ A ++ A + E+ESR+ +K R AG+ +EL ++ L
Sbjct: 1733 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1792
Query: 905 RTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSDTKYKILEGRN 964
R ED ++ +++++ +E E ++ E+ L+E ++ ++ ++ E +
Sbjct: 1793 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE--D 1850
Query: 965 ESALKTTLAMKEEKIVLLEAQMEEK-ASLNRQLESELQMLKKECE-TLRQN---QGEGQH 1019
E+ + L EE+ +A +EE+ A L + +SEL+ K E TLRQ + E
Sbjct: 1851 EAFQRRRL---EEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA 1907
Query: 1020 LQNSF-KHPAGKTAAS------HQGKEAWGPGHKEATMELLRVKDRAIELE--RNNAALQ 1070
L+ SF K AGK E ++A +E R + A E E R A +
Sbjct: 1908 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 1967
Query: 1071 AEKQLLKEQLQHLETQNVTFSSQILTLQKQSA----FLQEHNTTLQTQTAKLQVENSTLS 1126
+K L E+ + + + L + + A E + Q Q A+ + +
Sbjct: 1968 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2027
Query: 1127 SQSAALTAQYTLLQNHHTAKETENESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYE 1186
+ A A Q + E L + + + AA A ++ E ER++A+
Sbjct: 2028 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA-AEEAEEARVQAEREAAQSR 2086
Query: 1187 ALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAELEEREKVLTTEREALQQEQRTNAL 1246
+ + LK + + + + + L+++AE +E + E+ AL+Q+Q +A
Sbjct: 2087 RQVEEAERLKQSAEE-QAQARAQAQAAAEKLRKEAE-QEAARRAQAEQAALRQKQAADA- 2143
Query: 1247 AMGENQRLRGELDRVNFLHHQLKGEYEELHAHTKELKTSLNNAQLELNRWQARFDELKEQ 1306
E ++ + ++ Q++ E L +E N EL R +A E Q
Sbjct: 2144 ---EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2200
Query: 1307 HQTMDISLTKLDNHCELLSRLKGNLEEENHHLLSQIQLLSQQNQMLLEQNMENKEQYHEE 1366
++ L + E LS+LK +E EN L+ + + Q L++ E +Q EE
Sbjct: 2201 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK---DNTQRFLQEEAEKMKQVAEE 2257
Query: 1367 QKQYIDKLNALRRHKEKLEEKIMDQYKFYDPPPKKKNHWI----GAKALVKLIKPKKEGS 1422
+ R ++ EE + Q + K+K + KA +L++ +KE +
Sbjct: 2258 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA 2317
Query: 1423 RERLK 1427
+E+ +
Sbjct: 2318 QEQAR 2322
Score = 119 bits (299), Expect = 2e-26
Identities = 167/790 (21%), Positives = 355/790 (44%), Gaps = 131/790 (16%)
Query: 249 KQHLAVELADTKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSA 308
++ A AD + RL ++R+ + + E+ + V+ + + ++V++E + L A A
Sbjct: 1859 EEQAAQHKADIEERLAQLRKASDSELER---QKGLVEDTLRQRRQVEEEILALKASFEKA 1915
Query: 309 RAYRDEL------------DSLREKANRVERLELELTRCKEKLHDVDFYKARMEELREDN 356
A + EL D+LR K E+ ELE R ++ + + + EE + +
Sbjct: 1916 AAGKAELELELGRIRSNAEDTLRSK----EQAELEAARQRQLAAEEERRRREAEERVQKS 1971
Query: 357 IILIET-----KAMLEEQLTAARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIE-- 409
+ E KA LEE + +A+ ++ L + Q ++ L+L ++ +KR++
Sbjct: 1972 LAAEEEAARQRKAALEE-VERLKAKVEEARRLRERAEQESAR--QLQLAQEAAQKRLQAE 2028
Query: 410 --------ELLEENMVLEIAQKQSMNESAHLGWELEQLSKNADLSDASRKSFVFELNECA 461
+ E+ + + Q+QS+ + L E E + A+ ++ +R V E A
Sbjct: 2029 EKAHAFAVQQKEQELQQTLQQEQSVLDQ--LRGEAEAARRAAEEAEEAR---VQAEREAA 2083
Query: 462 SSR--ILKLEKENQSLQSTIQGLRDASLVLEESGLKCGELEKENHQ-LSKKIEKLQTQLE 518
SR + + E+ QS + Q A E+ L KE Q +++ + Q L
Sbjct: 2084 QSRRQVEEAERLKQSAEEQAQARAQAQAAAEK-------LRKEAEQEAARRAQAEQAALR 2136
Query: 519 REKQSNQDLET---LSEELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSL-- 573
+++ ++ ++E +E+ +R+K Q++ ++ TL+ Q+++ + +K+ L+ + L
Sbjct: 2137 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL----QLEETDHQKNLLDEELQRLKA 2192
Query: 574 ------RERSQVSSEARMKDVEKENKALHQTVTEANGK---LSQLEFEKRQLHRDLEQAK 624
R+RSQV E V+ E + + EA + L + +R L + E+ K
Sbjct: 2193 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2252
Query: 625 EKGERAEKLE------RELQRLQEEN---------GRLARKVTSLETATE---KVEALEH 666
+ E A +L L++L EE+ L K+ +++ AT + E L+
Sbjct: 2253 QVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2312
Query: 667 ESQGLQLENRTLRKSLDTL-QNVSLQLEGLERDNKQLDAENLELRRLVETMRFTSTKLAQ 725
+ + Q + R L++ + + Q ++ + +G +R + LE+ E ++ ++A+
Sbjct: 2313 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL---RVAE 2369
Query: 726 MERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLE----SSSHK 781
M R + E + + RK + +G+K R EL+ Q E + L Q+LE S H
Sbjct: 2370 MSRAQARAEEDAQRFRKQAE---EIGEKLHRTELATQ----EKVTLVQTLEIQRQQSDHD 2422
Query: 782 TQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQ---LEKDKKLLE 838
+ L + ELE E++ L+++ + L+L + +++ ++++ E + Q L + LL+
Sbjct: 2423 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2482
Query: 839 KEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDNRDLTK 898
+E +E+E L++ +D K ++L ++ + +
Sbjct: 2483 RE----------------------RFIEQEKAKLEQLF---QDEVAKAQQLREEQQRQQQ 2517
Query: 899 QVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSDTKYK 958
Q+ + L E+ + ++++ + Q+LE+ +E LL E++ + +
Sbjct: 2518 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2577
Query: 959 ILEGRNESAL 968
+LE ++ +AL
Sbjct: 2578 LLEEQHRAAL 2587
Score = 115 bits (289), Expect = 3e-25
Identities = 180/779 (23%), Positives = 323/779 (41%), Gaps = 104/779 (13%)
Query: 247 EDKQHLAVELADTKARLRRVRQELEDKTEQLVDTRHE--VDQLVLELQKVKQENI----Q 300
E+ + L AR ++ QE K Q + H V Q ELQ+ Q+ Q
Sbjct: 1997 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2056
Query: 301 LAADARSARAYRDELDSLREKANRVERLELELTRCKEKLHDVDFYKARMEELREDNIILI 360
L +A +AR +E + R +A R E + + ++ + + K EE
Sbjct: 2057 LRGEAEAARRAAEEAEEARVQAER------EAAQSRRQVEEAERLKQSAEE--------- 2101
Query: 361 ETKAMLEEQLTAARARGDKVHELEK----ENLQLKSKLHDLELDRDTDKKRIEELLEENM 416
+ +A + Q A + R + E + E L+ K + + + KK E+ L +
Sbjct: 2102 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK-QAADAEMEKHKKFAEQTLRQKA 2160
Query: 417 VLEIAQKQSMNESAHLGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQ 476
+E E L +LE+ +L D + E E A R ++E+E S++
Sbjct: 2161 QVE-------QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS-QVEEELFSVR 2212
Query: 477 STIQGLRDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLS---EE 533
++ L +E +K+N Q LQ + E+ KQ ++ LS +E
Sbjct: 2213 VQMEELSKLKARIEAENRALILRDKDNTQ-----RFLQEEAEKMKQVAEEAARLSVAAQE 2267
Query: 534 LIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENK 593
R ++ + D+ +A + +K+ M +++E +++ +EA + +KE
Sbjct: 2268 AARLRQLAEEDLAQQRALAEKMLKE----------KMQAVQEATRLKAEAELLQQQKEL- 2316
Query: 594 ALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQ-RLQEENGRLARKVT 652
A + +L+ +K Q+ + L + + +R + ER+ Q + E RL +V
Sbjct: 2317 --------AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2368
Query: 653 SLETATEKVE--ALEHESQGLQLENRTLRKSLDTLQNVSL-QLEGLERDNKQLDAENL-- 707
+ A + E A Q ++ + R L T + V+L Q ++R DAE L
Sbjct: 2369 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2428
Query: 708 ---ELRRLVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSV 764
EL R E ++ KL Q++ E Q ++++ L++ L ++ + + L + +
Sbjct: 2429 AIAELEREKEKLQ-QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI 2487
Query: 765 SAENLRLQQSLESSSHKTQTLESELG----ELEAERQALRRDLE-ALRLANAQLEGAEKD 819
E +L+Q + K Q L E ++E ERQ L +E A R + EG +
Sbjct: 2488 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2547
Query: 820 RKALEQEVAQLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARC 879
++ L+Q Q + ++LL +E +RL +Q++L + + A V A K L
Sbjct: 2548 QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNG 2607
Query: 880 RDAA-GKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSS--ELDKLSQELE 936
RDA G E E ++ + LR + ++L+ + S EL +L+Q
Sbjct: 2608 RDALDGPAAEAEPEH------------SFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2655
Query: 937 KVGLNRELLLQED-----DSGSDTKYKILEGRNE-----SALKTTLAMKEEKIVLLEAQ 985
V EL +ED S +L+ NE +AL+ L ++LLEAQ
Sbjct: 2656 TVD---ELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQ 2711
Score = 60.1 bits (144), Expect = 2e-08
Identities = 210/986 (21%), Positives = 366/986 (37%), Gaps = 189/986 (19%)
Query: 490 EESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSDMETLK 549
EE G + + L +LE +++ ++L+ + L+RE + +E+ +
Sbjct: 616 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 675
Query: 550 ADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQ---TVTEANGKL 606
A Q WS + EA +K EN A Q V EA G+L
Sbjct: 676 AALQTQ---------------WSWMLQLCCCIEAHLK----ENAAYFQFFSDVREAEGQL 716
Query: 607 SQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGRL-------------ARKVTS 653
+L+ R+ + + ++ +LE LQ Q+E +L A+ V
Sbjct: 717 QKLQEALRRKY-----SCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQ 771
Query: 654 LETAT-----------------EKVEALEHESQGLQLENRTLRKSLDTLQNVSLQL---- 692
L+ ++VE H+ QL L + +
Sbjct: 772 LKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPS 831
Query: 693 ---------EGLERDNKQLDAENLELRRLVETMRFTSTKLAQMERENQQLEREKEELRK- 742
+ + +L+A++ L L + L Q L R+ + +R
Sbjct: 832 VCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAW----QSLRRDVQLIRSW 887
Query: 743 NVDLLKALGKKSER-----LELSYQSVSAEN-----------LRLQQSLESSSHKTQTLE 786
++ + L + +R LEL YQ+ ++ L ++ S SH Q L
Sbjct: 888 SLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLL 947
Query: 787 SELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQ 846
L + E +R + L+ QLE E +L DK+ + A+R+ +
Sbjct: 948 QSLEQGAQEESRCQRCISELKDIRLQLEACE----TRTVHRLRLPLDKEPARECAQRIAE 1003
Query: 847 QVELKDAV--LDDSTAKLSAVEKESRALDKELARCRDAAGKLK-ELEKDNRDLTKQVTVH 903
Q + + V L A+LSA ++ AL + AA L+ ELE LT
Sbjct: 1004 QQKAQAEVEGLGKGVARLSAEAEKVLALPEP----SPAAPTLRSELE-----LTLGKLEQ 1054
Query: 904 ARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDS---------GSD 954
R+L+ + LEKLK+ L + + +Q E+V E L+E + +
Sbjct: 1055 VRSLSA----IYLEKLKTISL---VIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK 1107
Query: 955 TKYKILEGRNESALKTTLAMKEE-------KIVLLEAQMEEKASLNRQLESELQMLKKEC 1007
K L + E+ T A+++E L + E + R E Q+L++
Sbjct: 1108 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1167
Query: 1008 ETLRQ---NQGEGQHLQNSFKH------PAG---KTAASHQGK-EAWGPGHKEATMELLR 1054
L Q Q E + L ++ P G + A Q + +A +A E LR
Sbjct: 1168 AVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLR 1227
Query: 1055 VKDRAI-ELERNNAALQAEKQLLKEQLQHL---ETQNVTFSSQI--LTLQKQSAFLQEHN 1108
+ + E+ER+ ++ ++ K+ + + E Q VT+ +Q+ + + +Q +
Sbjct: 1228 QEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1287
Query: 1109 TTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETENESLQRQQ----EQLTAAY 1164
++ + L+ S L++ LT+QY + + E E L QQ + A
Sbjct: 1288 ESVIQEYVDLRTHYSELTT----LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1343
Query: 1165 EALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAELE 1224
EA L+ L H + A+ E K L + ++ E E D ++K ++
Sbjct: 1344 EAALEKQRQLAEAHAQAKAQAERE------AKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1397
Query: 1225 EREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQL----------KGEYEE 1274
E + L EA Q + A A E RLR E + + + QL +GE +
Sbjct: 1398 EELQQLRQSSEAEIQAKARQAEA-AERSRLRIE-EEIRVVRLQLEATERQRGGAEGELQA 1455
Query: 1275 LHAHTKELKTSLNNAQLELNRWQARFDELKEQHQTMDISLTKLDNHCELLSRLKGNLEEE 1334
L A +E + AQ E R + Q D S K EL SR+K E
Sbjct: 1456 LRARAEEAEAQKRQAQEEAERL---------RRQVQDESQRKRQAEVELASRVKAEAEAA 1506
Query: 1335 NH-----HLLSQIQLLSQQNQMLLEQ 1355
L +++L +++ + L Q
Sbjct: 1507 REKQRALQALEELRLQAEEAERRLRQ 1532
Score = 41.2 bits (95), Expect = 0.010
Identities = 95/403 (23%), Positives = 166/403 (41%), Gaps = 61/403 (15%)
Query: 519 REKQSNQDLETLSEELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQ 578
R S +++E L + ++ KE ++ +ADK R K + Q + +A + +
Sbjct: 284 RFPSSFEEIEILWSQFLKFKEM---ELPAKEADKNRS-KGIYQSLEGAVQA-----GQLK 334
Query: 579 VSSEARMKDVEKENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQ 638
V DVEKE LH + LE EK Q + + ER E L+R +
Sbjct: 335 VPPGYHPLDVEKEWGKLHVAI---------LEREK--------QLRSEFERLECLQRIVT 377
Query: 639 RLQEENGRLARKVTSLET-------------ATEKVEALEHESQGLQLENRTLRKSLDTL 685
+LQ E G ++ + ++ +E + R L + TL
Sbjct: 378 KLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTL 437
Query: 686 QN-VSLQLEGLERDNKQLDAENLELR-----RLVETMRFTSTKLAQMERENQQLEREKEE 739
++ Q E + R +L + +R RL + +T++AQ+ ++ Q E E+
Sbjct: 438 KDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELED 497
Query: 740 --LRKNVDLLKALGKKSERLE-----LSYQSVSAE---NLRLQQSLESSSHKTQTLESEL 789
LR DLL + + R++ + SV A+ + L QS+E K + S+
Sbjct: 498 STLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDE 557
Query: 790 GELE-AERQALRRDLEALRLANAQLEGAEKDR----KALEQEVAQLEKDKKLL-EKEAKR 843
G+L A R A R L L L A+L + K R ++L VA K+ L EKE +
Sbjct: 558 GQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEE 617
Query: 844 LWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKL 886
+ ++ + SA+ +E +K++ ++A +L
Sbjct: 618 VGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRL 660
Score = 39.7 bits (91), Expect = 0.030
Identities = 160/919 (17%), Positives = 365/919 (39%), Gaps = 102/919 (11%)
Query: 614 RQLHRDLEQAKEKGERAEKLERELQ-----RLQEENGRLARKVTS-LETATEKVEALEHE 667
R LH+ +E+ + K ERA E +L ++ GRL + L ++ ++ +LE
Sbjct: 537 RGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESL 596
Query: 668 SQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVETMRFTSTKLAQME 727
+ + L L+ + + + +R N + A+ L+ + K+ +++
Sbjct: 597 HSFVAAATKEL-MWLNEKEEEEVGFDWSDR-NTNMTAKKESYSALMRELELKEKKIKELQ 654
Query: 728 RENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSSHKTQTLES 787
+L RE R V+ +A + Q L+++ + E+
Sbjct: 655 NAGDRLLREDHPARPTVESFQA--ALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREA 712
Query: 788 ELGELEAERQALRRDLEALRLAN-AQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQ 846
E G+L+ ++ALRR R A +LE +D + E QL + K L AKR
Sbjct: 713 E-GQLQKLQEALRRKYSCDRSATVTRLEDLLQD---AQDEKEQLNEYKGHLSGLAKRAKA 768
Query: 847 QVELKD--------------AVLD----------------------------DSTAKLSA 864
V+LK AV D S+ +A
Sbjct: 769 VVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAA 828
Query: 865 VEKESRALDKELARCRDAAGKLKELEKDNRDLTKQVTVHARTL---TTLREDLVLEKLKS 921
V + ++A +L+ + L Q+ V ++L +LR D+ L ++S
Sbjct: 829 VPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQL--IRS 886
Query: 922 QQLSS----ELDKLSQELEKVGLNRELLLQ--EDDSGSDTKYKILEGRNESALKTTLAMK 975
L++ + ++ Q L + L+ + L+ +D G + +++ R +
Sbjct: 887 WSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHY--- 943
Query: 976 EEKIVLLEAQMEEKASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTA--- 1032
++ + LE +E++ R + SEL+ ++ + E L K PA + A
Sbjct: 944 QQLLQSLEQGAQEESRCQRCI-SELKDIRLQLEACETRTVHRLRLPLD-KEPARECAQRI 1001
Query: 1033 ASHQGKEAWGPGHKEATMELLRVKDRAIELERNNAA---LQAEKQLLKEQLQHLETQNVT 1089
A Q +A G + L ++ + L + A L++E +L +L+ + + +
Sbjct: 1002 AEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1061
Query: 1090 FSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETE 1149
+ ++ T+ Q L+ +L+ E + + L A L+ E +
Sbjct: 1062 YLEKLKTISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKASLKKLRAQAEAQ 1120
Query: 1150 NESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKEL 1209
+ +++L A E E L H + E E R+ L ++
Sbjct: 1121 QPTFDALRDELRGAQEV----GERLQQRHGERDVEVERW-RERVAQLLERWQAVLAQTDV 1175
Query: 1210 GERHGDMLKRKAEL--EEREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQ 1267
+R + L R+ E + + ++A +++++ A+ + ++Q +R +L + L +
Sbjct: 1176 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1235
Query: 1268 LK--GE-YEELHAHTKELKTSLNNAQLELNRWQARFDEL---KEQHQTMDISLTKLDNHC 1321
++ GE EE K+ ++ + +L+L ++A+ + + ++ + S + + +
Sbjct: 1236 IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYV 1295
Query: 1322 EL---LSRLKGNLEEENHHLLSQIQLLSQQNQMLLEQNMENKEQYHE-----EQKQYIDK 1373
+L S L + + ++ + ++ ++ +Q E +E+ E E+++ + +
Sbjct: 1296 DLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAE 1355
Query: 1374 LNALRRHKEKLEEKIMDQYKFYDPPPKKKNHWIGAKALVKLIKPKKEGSRERLKSTVDSP 1433
+A + + + E K + Q + + +++ + A+ + I+ + + R+ ++ + +
Sbjct: 1356 AHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1414
Query: 1434 PWQLESSDPASPAASQPLR 1452
Q E+++ + + +R
Sbjct: 1415 ARQAEAAERSRLRIEEEIR 1433
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 168 bits (426), Expect = 4e-41
Identities = 277/1208 (22%), Positives = 494/1208 (40%), Gaps = 127/1208 (10%)
Query: 252 LAVELAD--TKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSAR 309
+A+E A +A L+ R +KT QL + E V +L++ + Q A+A AR
Sbjct: 1551 VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1610
Query: 310 AYRD-ELDSLREKANRVERLELELTRCKEKLHDVDFYKARMEELREDNIILIETKAMLEE 368
+ EL+ + KAN RL L+ +E +A E+ +E+ + EE
Sbjct: 1611 EEAERELERWQLKANEALRLRLQ---AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEE 1667
Query: 369 QLTAARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIEELLEENMVLEIAQKQSMNE 428
Q A R R ELEK+ +L T ++R+ +E + L +Q +
Sbjct: 1668 Q--AVRQRELAEQELEKQR----------QLAEGTAQQRLAAE-QELIRLRAETEQGEQQ 1714
Query: 429 SAHLGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASLV 488
L EL +L + A + R+ EL + + + L + ++ + + +
Sbjct: 1715 RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1774
Query: 489 LEESGLKCGELEKENHQLSKKIE--KLQTQLEREKQSNQDLETLSEELIREKEQLQSDME 546
LE + EL +E +L E K Q QL E + Q E +E ++ EK +
Sbjct: 1775 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE--AERVLAEKLAAIGEAT 1832
Query: 547 TLKADKARQIKDLEQEKDHLNRAMWS---LRERSQVSSEARMKDVEKE----NKALHQTV 599
LK + +K+ E E + L R R R + + D+E+ KA +
Sbjct: 1833 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1892
Query: 600 TEANGKLSQLEFEKRQLHRDLEQAKEKGERAE----KLERELQRLQE--ENGRLARKVTS 653
G + ++RQ+ ++ K E+A +LE EL R++ E+ +++
Sbjct: 1893 ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 1952
Query: 654 LETATEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLV 713
LE A ++ A E E + + E R ++KSL + + Q + + ++L A+ E RRL
Sbjct: 1953 LEAARQRQLAAEEERRRREAEER-VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLR 2011
Query: 714 ETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQ 773
E S + Q+ +E Q + EE A+ +K + L+ + Q + +L+
Sbjct: 2012 ERAEQESARQLQLAQEAAQKRLQAEEKAHAF----AVQQKEQELQQTLQQEQSVLDQLRG 2067
Query: 774 SLESSSHKTQTLESELGELEAERQAL--RRDLEALRLANAQLEGAEKDRKALEQEVAQLE 831
E++ + E+E ++AER+A RR +E A + AE+ +A Q A E
Sbjct: 2068 EAEAARRAAE--EAEEARVQAEREAAQSRRQVEE---AERLKQSAEEQAQARAQAQAAAE 2122
Query: 832 KDKKLLEKEAKRLWQ-------QVELKDAVLDDSTAKLSAVEKESRALDKELARCR---- 880
K +K E+EA R Q Q + DA ++ ++ +++EL R
Sbjct: 2123 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2182
Query: 881 DAAGKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGL 940
+ + L+++ + L + T AR + + E+L +++ ++LS ++ E
Sbjct: 2183 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE------ 2236
Query: 941 NRELLLQEDDSGS----DTKYKILEGRNESALKTTLAMK--------EEKIVLLEAQMEE 988
NR L+L++ D+ + K+ + E+A + A + EE + A E+
Sbjct: 2237 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEK 2296
Query: 989 KASLNRQLESELQMLKKECETLRQN----QGEGQHLQNSFKHPAGKTAASHQG----KEA 1040
Q E LK E E L+Q Q + + LQ + A + A QG EA
Sbjct: 2297 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2356
Query: 1041 WGPGHKEATMELLRVKDRAIELERNNAALQAEKQLLKEQLQH---------LETQNVTFS 1091
E + E R+K R E+ R A + + Q ++Q + L TQ
Sbjct: 2357 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2416
Query: 1092 SQILTLQKQSAF-----LQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAK 1146
Q L +Q+Q + L+E L+ + KLQ E L +S + +Q +
Sbjct: 2417 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQT----VQQEQLLQ 2472
Query: 1147 ETE--NESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLEL 1204
ET+ +S +++ L + Q+ L L + + A+ + L + + + +E
Sbjct: 2473 ETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ---QRQQQQMEQ 2529
Query: 1205 EHKELGERHGDMLKRKAELEEREKVLTTEREALQQEQRTNA-LAMGENQRLRGELDRVNF 1263
E + L + +R+ E EE + E + L+Q++R L ENQRLR +L +
Sbjct: 2530 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEE 2589
Query: 1264 LHHQLKGEYEELHAHTKELKTSLNNAQLELNRWQAR------FDELKEQHQTMDISLTKL 1317
H EE+ A +L N + L+ A FD L+ + + +
Sbjct: 2590 QHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGI 2649
Query: 1318 DNHCELLSRLKGNL--------EEENHHLLSQIQLLSQQNQMLLEQNMENKEQYHEEQKQ 1369
+ EL +G+ E+ H+L + + +LL+ E Y Q+Q
Sbjct: 2650 LSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAG----LLLKATNEKLSVYAALQRQ 2705
Query: 1370 YIDKLNAL 1377
+ AL
Sbjct: 2706 LLSPGTAL 2713
Score = 158 bits (399), Expect = 6e-38
Identities = 294/1385 (21%), Positives = 558/1385 (40%), Gaps = 161/1385 (11%)
Query: 176 ELPDVAPEELEALSRSMVLHLRRLIDQRD--ECTELIVDLTQERDYLQAQHPPSPIKSSS 233
EL D+ + LEA V LR +D+ EC + I + Q++ + + + S
Sbjct: 974 ELKDIRLQ-LEACETRTVHRLRLPLDKEPARECAQRIAE--QQKAQAEVEGLGKGVARLS 1030
Query: 234 ADSTPSPTSSLSSEDKQHLAVELADTKARLRRVR-----------------------QEL 270
A++ S L EL T +L +VR +E+
Sbjct: 1031 AEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEV 1090
Query: 271 EDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSAR----AYRDELDSLREKANRVE 326
E+ + V + EL+ K +L A A + + A RDEL +E R++
Sbjct: 1091 LRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQ 1150
Query: 327 RL----ELELTRCKEK-----------LHDVDFYKARMEELREDNIILIETKAMLEEQLT 371
+ ++E+ R +E+ L D + +E+L E+ L L
Sbjct: 1151 QRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQ 1210
Query: 372 AARARGDKVHELEKENLQ-LKSKLHDLELDRDTDKKRIEELLEENMVLEIAQ---KQSMN 427
AR R +++ + + Q ++ +L ++ +EE+ +E Q KQ +N
Sbjct: 1211 DARRRQEQIQAMPLADSQAVREQLRQ-------EQALLEEIERHGEKVEECQRFAKQYIN 1263
Query: 428 ESAHLGWELEQLSKNADL---SDASRKSFVFELNECASSRILKLEKENQSLQS-TIQGLR 483
A +EL+ ++ A L + ++K V +E + L L + T Q ++
Sbjct: 1264 --AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK 1321
Query: 484 DASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQS 543
S L + E++ + +++ +++ LE+++Q + + RE ++LQ
Sbjct: 1322 FISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1381
Query: 544 DMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKA--------- 594
M+ + D +Q+K + + LR+ S+ +A+ + E ++
Sbjct: 1382 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1441
Query: 595 ---LHQTVTE-----ANGKLSQLEFEKRQLHRDLEQAKEKGERAEK-LERELQRLQEENG 645
L TE A G+L L + QA+E+ ER + ++ E QR ++
Sbjct: 1442 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1501
Query: 646 RLARKV-TSLETATEKVEAL----EHESQGLQLENRTLRKSLDTLQNVSLQLEGLERD-- 698
LA +V E A EK AL E Q + E R + ++ + V + LE +R
Sbjct: 1502 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1561
Query: 699 -----------------NKQLDAENLELRRLVETMRFTSTKLAQMERENQQLEREKE--E 739
+ L E++ + +L E + + A+ ER ++ ERE E +
Sbjct: 1562 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1621
Query: 740 LRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLES----SSHKTQTLESELGELEAE 795
L+ N L L + + S AE + + E+ + + + EL E E E
Sbjct: 1622 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1681
Query: 796 R----------QALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLW 845
+ Q L + E +RL A+ E E+ R+ LE+E+A+L+++ ++ + L
Sbjct: 1682 KQRQLAEGTAQQRLAAEQELIRL-RAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1740
Query: 846 QQVELKDAVLDDSTAKLSAVEKESRAL-DKELARCRDAAGKLKELEKDNRDLTKQVTVHA 904
++ A ++ A + E+ESR+ +K R AG+ +EL ++ L
Sbjct: 1741 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1800
Query: 905 RTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSDTKYKILEGRN 964
R ED ++ +++++ +E E ++ E+ L+E ++ ++ ++ E +
Sbjct: 1801 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE--D 1858
Query: 965 ESALKTTLAMKEEKIVLLEAQMEEK-ASLNRQLESELQMLKKECE-TLRQN---QGEGQH 1019
E+ + L EE+ +A +EE+ A L + +SEL+ K E TLRQ + E
Sbjct: 1859 EAFQRRRL---EEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA 1915
Query: 1020 LQNSF-KHPAGKTAAS------HQGKEAWGPGHKEATMELLRVKDRAIELE--RNNAALQ 1070
L+ SF K AGK E ++A +E R + A E E R A +
Sbjct: 1916 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 1975
Query: 1071 AEKQLLKEQLQHLETQNVTFSSQILTLQKQSA----FLQEHNTTLQTQTAKLQVENSTLS 1126
+K L E+ + + + L + + A E + Q Q A+ + +
Sbjct: 1976 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2035
Query: 1127 SQSAALTAQYTLLQNHHTAKETENESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYE 1186
+ A A Q + E L + + + AA A ++ E ER++A+
Sbjct: 2036 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA-AEEAEEARVQAEREAAQSR 2094
Query: 1187 ALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAELEEREKVLTTEREALQQEQRTNAL 1246
+ + LK + + + + + L+++AE +E + E+ AL+Q+Q +A
Sbjct: 2095 RQVEEAERLKQSAEE-QAQARAQAQAAAEKLRKEAE-QEAARRAQAEQAALRQKQAADA- 2151
Query: 1247 AMGENQRLRGELDRVNFLHHQLKGEYEELHAHTKELKTSLNNAQLELNRWQARFDELKEQ 1306
E ++ + ++ Q++ E L +E N EL R +A E Q
Sbjct: 2152 ---EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2208
Query: 1307 HQTMDISLTKLDNHCELLSRLKGNLEEENHHLLSQIQLLSQQNQMLLEQNMENKEQYHEE 1366
++ L + E LS+LK +E EN L+ + + Q L++ E +Q EE
Sbjct: 2209 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK---DNTQRFLQEEAEKMKQVAEE 2265
Query: 1367 QKQYIDKLNALRRHKEKLEEKIMDQYKFYDPPPKKKNHWI----GAKALVKLIKPKKEGS 1422
+ R ++ EE + Q + K+K + KA +L++ +KE +
Sbjct: 2266 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA 2325
Query: 1423 RERLK 1427
+E+ +
Sbjct: 2326 QEQAR 2330
Score = 119 bits (299), Expect = 2e-26
Identities = 167/790 (21%), Positives = 355/790 (44%), Gaps = 131/790 (16%)
Query: 249 KQHLAVELADTKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSA 308
++ A AD + RL ++R+ + + E+ + V+ + + ++V++E + L A A
Sbjct: 1867 EEQAAQHKADIEERLAQLRKASDSELER---QKGLVEDTLRQRRQVEEEILALKASFEKA 1923
Query: 309 RAYRDEL------------DSLREKANRVERLELELTRCKEKLHDVDFYKARMEELREDN 356
A + EL D+LR K E+ ELE R ++ + + + EE + +
Sbjct: 1924 AAGKAELELELGRIRSNAEDTLRSK----EQAELEAARQRQLAAEEERRRREAEERVQKS 1979
Query: 357 IILIET-----KAMLEEQLTAARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIE-- 409
+ E KA LEE + +A+ ++ L + Q ++ L+L ++ +KR++
Sbjct: 1980 LAAEEEAARQRKAALEE-VERLKAKVEEARRLRERAEQESAR--QLQLAQEAAQKRLQAE 2036
Query: 410 --------ELLEENMVLEIAQKQSMNESAHLGWELEQLSKNADLSDASRKSFVFELNECA 461
+ E+ + + Q+QS+ + L E E + A+ ++ +R V E A
Sbjct: 2037 EKAHAFAVQQKEQELQQTLQQEQSVLDQ--LRGEAEAARRAAEEAEEAR---VQAEREAA 2091
Query: 462 SSR--ILKLEKENQSLQSTIQGLRDASLVLEESGLKCGELEKENHQ-LSKKIEKLQTQLE 518
SR + + E+ QS + Q A E+ L KE Q +++ + Q L
Sbjct: 2092 QSRRQVEEAERLKQSAEEQAQARAQAQAAAEK-------LRKEAEQEAARRAQAEQAALR 2144
Query: 519 REKQSNQDLET---LSEELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSL-- 573
+++ ++ ++E +E+ +R+K Q++ ++ TL+ Q+++ + +K+ L+ + L
Sbjct: 2145 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL----QLEETDHQKNLLDEELQRLKA 2200
Query: 574 ------RERSQVSSEARMKDVEKENKALHQTVTEANGK---LSQLEFEKRQLHRDLEQAK 624
R+RSQV E V+ E + + EA + L + +R L + E+ K
Sbjct: 2201 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2260
Query: 625 EKGERAEKLE------RELQRLQEEN---------GRLARKVTSLETATE---KVEALEH 666
+ E A +L L++L EE+ L K+ +++ AT + E L+
Sbjct: 2261 QVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2320
Query: 667 ESQGLQLENRTLRKSLDTL-QNVSLQLEGLERDNKQLDAENLELRRLVETMRFTSTKLAQ 725
+ + Q + R L++ + + Q ++ + +G +R + LE+ E ++ ++A+
Sbjct: 2321 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL---RVAE 2377
Query: 726 MERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLE----SSSHK 781
M R + E + + RK + +G+K R EL+ Q E + L Q+LE S H
Sbjct: 2378 MSRAQARAEEDAQRFRKQAE---EIGEKLHRTELATQ----EKVTLVQTLEIQRQQSDHD 2430
Query: 782 TQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQ---LEKDKKLLE 838
+ L + ELE E++ L+++ + L+L + +++ ++++ E + Q L + LL+
Sbjct: 2431 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2490
Query: 839 KEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDNRDLTK 898
+E +E+E L++ +D K ++L ++ + +
Sbjct: 2491 RE----------------------RFIEQEKAKLEQLF---QDEVAKAQQLREEQQRQQQ 2525
Query: 899 QVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSDTKYK 958
Q+ + L E+ + ++++ + Q+LE+ +E LL E++ + +
Sbjct: 2526 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2585
Query: 959 ILEGRNESAL 968
+LE ++ +AL
Sbjct: 2586 LLEEQHRAAL 2595
Score = 115 bits (289), Expect = 3e-25
Identities = 180/779 (23%), Positives = 323/779 (41%), Gaps = 104/779 (13%)
Query: 247 EDKQHLAVELADTKARLRRVRQELEDKTEQLVDTRHE--VDQLVLELQKVKQENI----Q 300
E+ + L AR ++ QE K Q + H V Q ELQ+ Q+ Q
Sbjct: 2005 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2064
Query: 301 LAADARSARAYRDELDSLREKANRVERLELELTRCKEKLHDVDFYKARMEELREDNIILI 360
L +A +AR +E + R +A R E + + ++ + + K EE
Sbjct: 2065 LRGEAEAARRAAEEAEEARVQAER------EAAQSRRQVEEAERLKQSAEE--------- 2109
Query: 361 ETKAMLEEQLTAARARGDKVHELEK----ENLQLKSKLHDLELDRDTDKKRIEELLEENM 416
+ +A + Q A + R + E + E L+ K + + + KK E+ L +
Sbjct: 2110 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK-QAADAEMEKHKKFAEQTLRQKA 2168
Query: 417 VLEIAQKQSMNESAHLGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQ 476
+E E L +LE+ +L D + E E A R ++E+E S++
Sbjct: 2169 QVE-------QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS-QVEEELFSVR 2220
Query: 477 STIQGLRDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLS---EE 533
++ L +E +K+N Q LQ + E+ KQ ++ LS +E
Sbjct: 2221 VQMEELSKLKARIEAENRALILRDKDNTQ-----RFLQEEAEKMKQVAEEAARLSVAAQE 2275
Query: 534 LIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENK 593
R ++ + D+ +A + +K+ M +++E +++ +EA + +KE
Sbjct: 2276 AARLRQLAEEDLAQQRALAEKMLKE----------KMQAVQEATRLKAEAELLQQQKEL- 2324
Query: 594 ALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQ-RLQEENGRLARKVT 652
A + +L+ +K Q+ + L + + +R + ER+ Q + E RL +V
Sbjct: 2325 --------AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2376
Query: 653 SLETATEKVE--ALEHESQGLQLENRTLRKSLDTLQNVSL-QLEGLERDNKQLDAENL-- 707
+ A + E A Q ++ + R L T + V+L Q ++R DAE L
Sbjct: 2377 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2436
Query: 708 ---ELRRLVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSV 764
EL R E ++ KL Q++ E Q ++++ L++ L ++ + + L + +
Sbjct: 2437 AIAELEREKEKLQ-QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI 2495
Query: 765 SAENLRLQQSLESSSHKTQTLESELG----ELEAERQALRRDLE-ALRLANAQLEGAEKD 819
E +L+Q + K Q L E ++E ERQ L +E A R + EG +
Sbjct: 2496 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2555
Query: 820 RKALEQEVAQLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARC 879
++ L+Q Q + ++LL +E +RL +Q++L + + A V A K L
Sbjct: 2556 QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNG 2615
Query: 880 RDAA-GKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSS--ELDKLSQELE 936
RDA G E E ++ + LR + ++L+ + S EL +L+Q
Sbjct: 2616 RDALDGPAAEAEPEH------------SFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2663
Query: 937 KVGLNRELLLQED-----DSGSDTKYKILEGRNE-----SALKTTLAMKEEKIVLLEAQ 985
V EL +ED S +L+ NE +AL+ L ++LLEAQ
Sbjct: 2664 TVD---ELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQ 2719
Score = 60.1 bits (144), Expect = 2e-08
Identities = 210/986 (21%), Positives = 366/986 (37%), Gaps = 189/986 (19%)
Query: 490 EESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSDMETLK 549
EE G + + L +LE +++ ++L+ + L+RE + +E+ +
Sbjct: 624 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 683
Query: 550 ADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQ---TVTEANGKL 606
A Q WS + EA +K EN A Q V EA G+L
Sbjct: 684 AALQTQ---------------WSWMLQLCCCIEAHLK----ENAAYFQFFSDVREAEGQL 724
Query: 607 SQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGRL-------------ARKVTS 653
+L+ R+ + + ++ +LE LQ Q+E +L A+ V
Sbjct: 725 QKLQEALRRKY-----SCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQ 779
Query: 654 LETAT-----------------EKVEALEHESQGLQLENRTLRKSLDTLQNVSLQL---- 692
L+ ++VE H+ QL L + +
Sbjct: 780 LKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPS 839
Query: 693 ---------EGLERDNKQLDAENLELRRLVETMRFTSTKLAQMERENQQLEREKEELRK- 742
+ + +L+A++ L L + L Q L R+ + +R
Sbjct: 840 VCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAW----QSLRRDVQLIRSW 895
Query: 743 NVDLLKALGKKSER-----LELSYQSVSAEN-----------LRLQQSLESSSHKTQTLE 786
++ + L + +R LEL YQ+ ++ L ++ S SH Q L
Sbjct: 896 SLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLL 955
Query: 787 SELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQ 846
L + E +R + L+ QLE E +L DK+ + A+R+ +
Sbjct: 956 QSLEQGAQEESRCQRCISELKDIRLQLEACE----TRTVHRLRLPLDKEPARECAQRIAE 1011
Query: 847 QVELKDAV--LDDSTAKLSAVEKESRALDKELARCRDAAGKLK-ELEKDNRDLTKQVTVH 903
Q + + V L A+LSA ++ AL + AA L+ ELE LT
Sbjct: 1012 QQKAQAEVEGLGKGVARLSAEAEKVLALPEP----SPAAPTLRSELE-----LTLGKLEQ 1062
Query: 904 ARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDS---------GSD 954
R+L+ + LEKLK+ L + + +Q E+V E L+E + +
Sbjct: 1063 VRSLSA----IYLEKLKTISL---VIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK 1115
Query: 955 TKYKILEGRNESALKTTLAMKEE-------KIVLLEAQMEEKASLNRQLESELQMLKKEC 1007
K L + E+ T A+++E L + E + R E Q+L++
Sbjct: 1116 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1175
Query: 1008 ETLRQ---NQGEGQHLQNSFKH------PAG---KTAASHQGK-EAWGPGHKEATMELLR 1054
L Q Q E + L ++ P G + A Q + +A +A E LR
Sbjct: 1176 AVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLR 1235
Query: 1055 VKDRAI-ELERNNAALQAEKQLLKEQLQHL---ETQNVTFSSQI--LTLQKQSAFLQEHN 1108
+ + E+ER+ ++ ++ K+ + + E Q VT+ +Q+ + + +Q +
Sbjct: 1236 QEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1295
Query: 1109 TTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETENESLQRQQ----EQLTAAY 1164
++ + L+ S L++ LT+QY + + E E L QQ + A
Sbjct: 1296 ESVIQEYVDLRTHYSELTT----LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1351
Query: 1165 EALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAELE 1224
EA L+ L H + A+ E K L + ++ E E D ++K ++
Sbjct: 1352 EAALEKQRQLAEAHAQAKAQAERE------AKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1405
Query: 1225 EREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQL----------KGEYEE 1274
E + L EA Q + A A E RLR E + + + QL +GE +
Sbjct: 1406 EELQQLRQSSEAEIQAKARQAEA-AERSRLRIE-EEIRVVRLQLEATERQRGGAEGELQA 1463
Query: 1275 LHAHTKELKTSLNNAQLELNRWQARFDELKEQHQTMDISLTKLDNHCELLSRLKGNLEEE 1334
L A +E + AQ E R + Q D S K EL SR+K E
Sbjct: 1464 LRARAEEAEAQKRQAQEEAERL---------RRQVQDESQRKRQAEVELASRVKAEAEAA 1514
Query: 1335 NH-----HLLSQIQLLSQQNQMLLEQ 1355
L +++L +++ + L Q
Sbjct: 1515 REKQRALQALEELRLQAEEAERRLRQ 1540
Score = 41.2 bits (95), Expect = 0.010
Identities = 95/403 (23%), Positives = 166/403 (41%), Gaps = 61/403 (15%)
Query: 519 REKQSNQDLETLSEELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQ 578
R S +++E L + ++ KE ++ +ADK R K + Q + +A + +
Sbjct: 292 RFPSSFEEIEILWSQFLKFKEM---ELPAKEADKNRS-KGIYQSLEGAVQA-----GQLK 342
Query: 579 VSSEARMKDVEKENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQ 638
V DVEKE LH + LE EK Q + + ER E L+R +
Sbjct: 343 VPPGYHPLDVEKEWGKLHVAI---------LEREK--------QLRSEFERLECLQRIVT 385
Query: 639 RLQEENGRLARKVTSLET-------------ATEKVEALEHESQGLQLENRTLRKSLDTL 685
+LQ E G ++ + ++ +E + R L + TL
Sbjct: 386 KLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTL 445
Query: 686 QN-VSLQLEGLERDNKQLDAENLELR-----RLVETMRFTSTKLAQMERENQQLEREKEE 739
++ Q E + R +L + +R RL + +T++AQ+ ++ Q E E+
Sbjct: 446 KDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELED 505
Query: 740 --LRKNVDLLKALGKKSERLE-----LSYQSVSAE---NLRLQQSLESSSHKTQTLESEL 789
LR DLL + + R++ + SV A+ + L QS+E K + S+
Sbjct: 506 STLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDE 565
Query: 790 GELE-AERQALRRDLEALRLANAQLEGAEKDR----KALEQEVAQLEKDKKLL-EKEAKR 843
G+L A R A R L L L A+L + K R ++L VA K+ L EKE +
Sbjct: 566 GQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEE 625
Query: 844 LWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKL 886
+ ++ + SA+ +E +K++ ++A +L
Sbjct: 626 VGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRL 668
Score = 39.7 bits (91), Expect = 0.030
Identities = 160/919 (17%), Positives = 365/919 (39%), Gaps = 102/919 (11%)
Query: 614 RQLHRDLEQAKEKGERAEKLERELQ-----RLQEENGRLARKVTS-LETATEKVEALEHE 667
R LH+ +E+ + K ERA E +L ++ GRL + L ++ ++ +LE
Sbjct: 545 RGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESL 604
Query: 668 SQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVETMRFTSTKLAQME 727
+ + L L+ + + + +R N + A+ L+ + K+ +++
Sbjct: 605 HSFVAAATKEL-MWLNEKEEEEVGFDWSDR-NTNMTAKKESYSALMRELELKEKKIKELQ 662
Query: 728 RENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSSHKTQTLES 787
+L RE R V+ +A + Q L+++ + E+
Sbjct: 663 NAGDRLLREDHPARPTVESFQA--ALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREA 720
Query: 788 ELGELEAERQALRRDLEALRLAN-AQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQ 846
E G+L+ ++ALRR R A +LE +D + E QL + K L AKR
Sbjct: 721 E-GQLQKLQEALRRKYSCDRSATVTRLEDLLQD---AQDEKEQLNEYKGHLSGLAKRAKA 776
Query: 847 QVELKD--------------AVLD----------------------------DSTAKLSA 864
V+LK AV D S+ +A
Sbjct: 777 VVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAA 836
Query: 865 VEKESRALDKELARCRDAAGKLKELEKDNRDLTKQVTVHARTL---TTLREDLVLEKLKS 921
V + ++A +L+ + L Q+ V ++L +LR D+ L ++S
Sbjct: 837 VPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQL--IRS 894
Query: 922 QQLSS----ELDKLSQELEKVGLNRELLLQ--EDDSGSDTKYKILEGRNESALKTTLAMK 975
L++ + ++ Q L + L+ + L+ +D G + +++ R +
Sbjct: 895 WSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHY--- 951
Query: 976 EEKIVLLEAQMEEKASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTA--- 1032
++ + LE +E++ R + SEL+ ++ + E L K PA + A
Sbjct: 952 QQLLQSLEQGAQEESRCQRCI-SELKDIRLQLEACETRTVHRLRLPLD-KEPARECAQRI 1009
Query: 1033 ASHQGKEAWGPGHKEATMELLRVKDRAIELERNNAA---LQAEKQLLKEQLQHLETQNVT 1089
A Q +A G + L ++ + L + A L++E +L +L+ + + +
Sbjct: 1010 AEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1069
Query: 1090 FSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETE 1149
+ ++ T+ Q L+ +L+ E + + L A L+ E +
Sbjct: 1070 YLEKLKTISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKASLKKLRAQAEAQ 1128
Query: 1150 NESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKEL 1209
+ +++L A E E L H + E E R+ L ++
Sbjct: 1129 QPTFDALRDELRGAQEV----GERLQQRHGERDVEVERW-RERVAQLLERWQAVLAQTDV 1183
Query: 1210 GERHGDMLKRKAEL--EEREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQ 1267
+R + L R+ E + + ++A +++++ A+ + ++Q +R +L + L +
Sbjct: 1184 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1243
Query: 1268 LK--GE-YEELHAHTKELKTSLNNAQLELNRWQARFDEL---KEQHQTMDISLTKLDNHC 1321
++ GE EE K+ ++ + +L+L ++A+ + + ++ + S + + +
Sbjct: 1244 IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYV 1303
Query: 1322 EL---LSRLKGNLEEENHHLLSQIQLLSQQNQMLLEQNMENKEQYHE-----EQKQYIDK 1373
+L S L + + ++ + ++ ++ +Q E +E+ E E+++ + +
Sbjct: 1304 DLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAE 1363
Query: 1374 LNALRRHKEKLEEKIMDQYKFYDPPPKKKNHWIGAKALVKLIKPKKEGSRERLKSTVDSP 1433
+A + + + E K + Q + + +++ + A+ + I+ + + R+ ++ + +
Sbjct: 1364 AHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1422
Query: 1434 PWQLESSDPASPAASQPLR 1452
Q E+++ + + +R
Sbjct: 1423 ARQAEAAERSRLRIEEEIR 1441
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 168 bits (426), Expect = 4e-41
Identities = 277/1208 (22%), Positives = 494/1208 (40%), Gaps = 127/1208 (10%)
Query: 252 LAVELAD--TKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSAR 309
+A+E A +A L+ R +KT QL + E V +L++ + Q A+A AR
Sbjct: 1592 VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1651
Query: 310 AYRD-ELDSLREKANRVERLELELTRCKEKLHDVDFYKARMEELREDNIILIETKAMLEE 368
+ EL+ + KAN RL L+ +E +A E+ +E+ + EE
Sbjct: 1652 EEAERELERWQLKANEALRLRLQ---AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEE 1708
Query: 369 QLTAARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIEELLEENMVLEIAQKQSMNE 428
Q A R R ELEK+ +L T ++R+ +E + L +Q +
Sbjct: 1709 Q--AVRQRELAEQELEKQR----------QLAEGTAQQRLAAE-QELIRLRAETEQGEQQ 1755
Query: 429 SAHLGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASLV 488
L EL +L + A + R+ EL + + + L + ++ + + +
Sbjct: 1756 RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1815
Query: 489 LEESGLKCGELEKENHQLSKKIE--KLQTQLEREKQSNQDLETLSEELIREKEQLQSDME 546
LE + EL +E +L E K Q QL E + Q E +E ++ EK +
Sbjct: 1816 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE--AERVLAEKLAAIGEAT 1873
Query: 547 TLKADKARQIKDLEQEKDHLNRAMWS---LRERSQVSSEARMKDVEKE----NKALHQTV 599
LK + +K+ E E + L R R R + + D+E+ KA +
Sbjct: 1874 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1933
Query: 600 TEANGKLSQLEFEKRQLHRDLEQAKEKGERAE----KLERELQRLQE--ENGRLARKVTS 653
G + ++RQ+ ++ K E+A +LE EL R++ E+ +++
Sbjct: 1934 ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 1993
Query: 654 LETATEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLV 713
LE A ++ A E E + + E R ++KSL + + Q + + ++L A+ E RRL
Sbjct: 1994 LEAARQRQLAAEEERRRREAEER-VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLR 2052
Query: 714 ETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQ 773
E S + Q+ +E Q + EE A+ +K + L+ + Q + +L+
Sbjct: 2053 ERAEQESARQLQLAQEAAQKRLQAEEKAHAF----AVQQKEQELQQTLQQEQSVLDQLRG 2108
Query: 774 SLESSSHKTQTLESELGELEAERQAL--RRDLEALRLANAQLEGAEKDRKALEQEVAQLE 831
E++ + E+E ++AER+A RR +E A + AE+ +A Q A E
Sbjct: 2109 EAEAARRAAE--EAEEARVQAEREAAQSRRQVEE---AERLKQSAEEQAQARAQAQAAAE 2163
Query: 832 KDKKLLEKEAKRLWQ-------QVELKDAVLDDSTAKLSAVEKESRALDKELARCR---- 880
K +K E+EA R Q Q + DA ++ ++ +++EL R
Sbjct: 2164 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2223
Query: 881 DAAGKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGL 940
+ + L+++ + L + T AR + + E+L +++ ++LS ++ E
Sbjct: 2224 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE------ 2277
Query: 941 NRELLLQEDDSGS----DTKYKILEGRNESALKTTLAMK--------EEKIVLLEAQMEE 988
NR L+L++ D+ + K+ + E+A + A + EE + A E+
Sbjct: 2278 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEK 2337
Query: 989 KASLNRQLESELQMLKKECETLRQN----QGEGQHLQNSFKHPAGKTAASHQG----KEA 1040
Q E LK E E L+Q Q + + LQ + A + A QG EA
Sbjct: 2338 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2397
Query: 1041 WGPGHKEATMELLRVKDRAIELERNNAALQAEKQLLKEQLQH---------LETQNVTFS 1091
E + E R+K R E+ R A + + Q ++Q + L TQ
Sbjct: 2398 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2457
Query: 1092 SQILTLQKQSAF-----LQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAK 1146
Q L +Q+Q + L+E L+ + KLQ E L +S + +Q +
Sbjct: 2458 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQT----VQQEQLLQ 2513
Query: 1147 ETE--NESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLEL 1204
ET+ +S +++ L + Q+ L L + + A+ + L + + + +E
Sbjct: 2514 ETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ---QRQQQQMEQ 2570
Query: 1205 EHKELGERHGDMLKRKAELEEREKVLTTEREALQQEQRTNA-LAMGENQRLRGELDRVNF 1263
E + L + +R+ E EE + E + L+Q++R L ENQRLR +L +
Sbjct: 2571 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEE 2630
Query: 1264 LHHQLKGEYEELHAHTKELKTSLNNAQLELNRWQAR------FDELKEQHQTMDISLTKL 1317
H EE+ A +L N + L+ A FD L+ + + +
Sbjct: 2631 QHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGI 2690
Query: 1318 DNHCELLSRLKGNL--------EEENHHLLSQIQLLSQQNQMLLEQNMENKEQYHEEQKQ 1369
+ EL +G+ E+ H+L + + +LL+ E Y Q+Q
Sbjct: 2691 LSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAG----LLLKATNEKLSVYAALQRQ 2746
Query: 1370 YIDKLNAL 1377
+ AL
Sbjct: 2747 LLSPGTAL 2754
Score = 158 bits (399), Expect = 6e-38
Identities = 294/1385 (21%), Positives = 558/1385 (40%), Gaps = 161/1385 (11%)
Query: 176 ELPDVAPEELEALSRSMVLHLRRLIDQRD--ECTELIVDLTQERDYLQAQHPPSPIKSSS 233
EL D+ + LEA V LR +D+ EC + I + Q++ + + + S
Sbjct: 1015 ELKDIRLQ-LEACETRTVHRLRLPLDKEPARECAQRIAE--QQKAQAEVEGLGKGVARLS 1071
Query: 234 ADSTPSPTSSLSSEDKQHLAVELADTKARLRRVR-----------------------QEL 270
A++ S L EL T +L +VR +E+
Sbjct: 1072 AEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEV 1131
Query: 271 EDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSAR----AYRDELDSLREKANRVE 326
E+ + V + EL+ K +L A A + + A RDEL +E R++
Sbjct: 1132 LRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQ 1191
Query: 327 RL----ELELTRCKEK-----------LHDVDFYKARMEELREDNIILIETKAMLEEQLT 371
+ ++E+ R +E+ L D + +E+L E+ L L
Sbjct: 1192 QRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQ 1251
Query: 372 AARARGDKVHELEKENLQ-LKSKLHDLELDRDTDKKRIEELLEENMVLEIAQ---KQSMN 427
AR R +++ + + Q ++ +L ++ +EE+ +E Q KQ +N
Sbjct: 1252 DARRRQEQIQAMPLADSQAVREQLRQ-------EQALLEEIERHGEKVEECQRFAKQYIN 1304
Query: 428 ESAHLGWELEQLSKNADL---SDASRKSFVFELNECASSRILKLEKENQSLQS-TIQGLR 483
A +EL+ ++ A L + ++K V +E + L L + T Q ++
Sbjct: 1305 --AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK 1362
Query: 484 DASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQS 543
S L + E++ + +++ +++ LE+++Q + + RE ++LQ
Sbjct: 1363 FISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1422
Query: 544 DMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKA--------- 594
M+ + D +Q+K + + LR+ S+ +A+ + E ++
Sbjct: 1423 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1482
Query: 595 ---LHQTVTE-----ANGKLSQLEFEKRQLHRDLEQAKEKGERAEK-LERELQRLQEENG 645
L TE A G+L L + QA+E+ ER + ++ E QR ++
Sbjct: 1483 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1542
Query: 646 RLARKV-TSLETATEKVEAL----EHESQGLQLENRTLRKSLDTLQNVSLQLEGLERD-- 698
LA +V E A EK AL E Q + E R + ++ + V + LE +R
Sbjct: 1543 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1602
Query: 699 -----------------NKQLDAENLELRRLVETMRFTSTKLAQMERENQQLEREKE--E 739
+ L E++ + +L E + + A+ ER ++ ERE E +
Sbjct: 1603 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1662
Query: 740 LRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLES----SSHKTQTLESELGELEAE 795
L+ N L L + + S AE + + E+ + + + EL E E E
Sbjct: 1663 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1722
Query: 796 R----------QALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLW 845
+ Q L + E +RL A+ E E+ R+ LE+E+A+L+++ ++ + L
Sbjct: 1723 KQRQLAEGTAQQRLAAEQELIRL-RAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1781
Query: 846 QQVELKDAVLDDSTAKLSAVEKESRAL-DKELARCRDAAGKLKELEKDNRDLTKQVTVHA 904
++ A ++ A + E+ESR+ +K R AG+ +EL ++ L
Sbjct: 1782 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1841
Query: 905 RTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSDTKYKILEGRN 964
R ED ++ +++++ +E E ++ E+ L+E ++ ++ ++ E +
Sbjct: 1842 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE--D 1899
Query: 965 ESALKTTLAMKEEKIVLLEAQMEEK-ASLNRQLESELQMLKKECE-TLRQN---QGEGQH 1019
E+ + L EE+ +A +EE+ A L + +SEL+ K E TLRQ + E
Sbjct: 1900 EAFQRRRL---EEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA 1956
Query: 1020 LQNSF-KHPAGKTAAS------HQGKEAWGPGHKEATMELLRVKDRAIELE--RNNAALQ 1070
L+ SF K AGK E ++A +E R + A E E R A +
Sbjct: 1957 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 2016
Query: 1071 AEKQLLKEQLQHLETQNVTFSSQILTLQKQSA----FLQEHNTTLQTQTAKLQVENSTLS 1126
+K L E+ + + + L + + A E + Q Q A+ + +
Sbjct: 2017 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2076
Query: 1127 SQSAALTAQYTLLQNHHTAKETENESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYE 1186
+ A A Q + E L + + + AA A ++ E ER++A+
Sbjct: 2077 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA-AEEAEEARVQAEREAAQSR 2135
Query: 1187 ALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAELEEREKVLTTEREALQQEQRTNAL 1246
+ + LK + + + + + L+++AE +E + E+ AL+Q+Q +A
Sbjct: 2136 RQVEEAERLKQSAEE-QAQARAQAQAAAEKLRKEAE-QEAARRAQAEQAALRQKQAADA- 2192
Query: 1247 AMGENQRLRGELDRVNFLHHQLKGEYEELHAHTKELKTSLNNAQLELNRWQARFDELKEQ 1306
E ++ + ++ Q++ E L +E N EL R +A E Q
Sbjct: 2193 ---EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2249
Query: 1307 HQTMDISLTKLDNHCELLSRLKGNLEEENHHLLSQIQLLSQQNQMLLEQNMENKEQYHEE 1366
++ L + E LS+LK +E EN L+ + + Q L++ E +Q EE
Sbjct: 2250 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK---DNTQRFLQEEAEKMKQVAEE 2306
Query: 1367 QKQYIDKLNALRRHKEKLEEKIMDQYKFYDPPPKKKNHWI----GAKALVKLIKPKKEGS 1422
+ R ++ EE + Q + K+K + KA +L++ +KE +
Sbjct: 2307 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA 2366
Query: 1423 RERLK 1427
+E+ +
Sbjct: 2367 QEQAR 2371
Score = 119 bits (299), Expect = 2e-26
Identities = 167/790 (21%), Positives = 355/790 (44%), Gaps = 131/790 (16%)
Query: 249 KQHLAVELADTKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSA 308
++ A AD + RL ++R+ + + E+ + V+ + + ++V++E + L A A
Sbjct: 1908 EEQAAQHKADIEERLAQLRKASDSELER---QKGLVEDTLRQRRQVEEEILALKASFEKA 1964
Query: 309 RAYRDEL------------DSLREKANRVERLELELTRCKEKLHDVDFYKARMEELREDN 356
A + EL D+LR K E+ ELE R ++ + + + EE + +
Sbjct: 1965 AAGKAELELELGRIRSNAEDTLRSK----EQAELEAARQRQLAAEEERRRREAEERVQKS 2020
Query: 357 IILIET-----KAMLEEQLTAARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIE-- 409
+ E KA LEE + +A+ ++ L + Q ++ L+L ++ +KR++
Sbjct: 2021 LAAEEEAARQRKAALEE-VERLKAKVEEARRLRERAEQESAR--QLQLAQEAAQKRLQAE 2077
Query: 410 --------ELLEENMVLEIAQKQSMNESAHLGWELEQLSKNADLSDASRKSFVFELNECA 461
+ E+ + + Q+QS+ + L E E + A+ ++ +R V E A
Sbjct: 2078 EKAHAFAVQQKEQELQQTLQQEQSVLDQ--LRGEAEAARRAAEEAEEAR---VQAEREAA 2132
Query: 462 SSR--ILKLEKENQSLQSTIQGLRDASLVLEESGLKCGELEKENHQ-LSKKIEKLQTQLE 518
SR + + E+ QS + Q A E+ L KE Q +++ + Q L
Sbjct: 2133 QSRRQVEEAERLKQSAEEQAQARAQAQAAAEK-------LRKEAEQEAARRAQAEQAALR 2185
Query: 519 REKQSNQDLET---LSEELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSL-- 573
+++ ++ ++E +E+ +R+K Q++ ++ TL+ Q+++ + +K+ L+ + L
Sbjct: 2186 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL----QLEETDHQKNLLDEELQRLKA 2241
Query: 574 ------RERSQVSSEARMKDVEKENKALHQTVTEANGK---LSQLEFEKRQLHRDLEQAK 624
R+RSQV E V+ E + + EA + L + +R L + E+ K
Sbjct: 2242 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2301
Query: 625 EKGERAEKLE------RELQRLQEEN---------GRLARKVTSLETATE---KVEALEH 666
+ E A +L L++L EE+ L K+ +++ AT + E L+
Sbjct: 2302 QVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2361
Query: 667 ESQGLQLENRTLRKSLDTL-QNVSLQLEGLERDNKQLDAENLELRRLVETMRFTSTKLAQ 725
+ + Q + R L++ + + Q ++ + +G +R + LE+ E ++ ++A+
Sbjct: 2362 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL---RVAE 2418
Query: 726 MERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLE----SSSHK 781
M R + E + + RK + +G+K R EL+ Q E + L Q+LE S H
Sbjct: 2419 MSRAQARAEEDAQRFRKQAE---EIGEKLHRTELATQ----EKVTLVQTLEIQRQQSDHD 2471
Query: 782 TQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQ---LEKDKKLLE 838
+ L + ELE E++ L+++ + L+L + +++ ++++ E + Q L + LL+
Sbjct: 2472 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2531
Query: 839 KEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDNRDLTK 898
+E +E+E L++ +D K ++L ++ + +
Sbjct: 2532 RE----------------------RFIEQEKAKLEQLF---QDEVAKAQQLREEQQRQQQ 2566
Query: 899 QVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSDTKYK 958
Q+ + L E+ + ++++ + Q+LE+ +E LL E++ + +
Sbjct: 2567 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2626
Query: 959 ILEGRNESAL 968
+LE ++ +AL
Sbjct: 2627 LLEEQHRAAL 2636
Score = 115 bits (289), Expect = 3e-25
Identities = 180/779 (23%), Positives = 323/779 (41%), Gaps = 104/779 (13%)
Query: 247 EDKQHLAVELADTKARLRRVRQELEDKTEQLVDTRHE--VDQLVLELQKVKQENI----Q 300
E+ + L AR ++ QE K Q + H V Q ELQ+ Q+ Q
Sbjct: 2046 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2105
Query: 301 LAADARSARAYRDELDSLREKANRVERLELELTRCKEKLHDVDFYKARMEELREDNIILI 360
L +A +AR +E + R +A R E + + ++ + + K EE
Sbjct: 2106 LRGEAEAARRAAEEAEEARVQAER------EAAQSRRQVEEAERLKQSAEE--------- 2150
Query: 361 ETKAMLEEQLTAARARGDKVHELEK----ENLQLKSKLHDLELDRDTDKKRIEELLEENM 416
+ +A + Q A + R + E + E L+ K + + + KK E+ L +
Sbjct: 2151 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK-QAADAEMEKHKKFAEQTLRQKA 2209
Query: 417 VLEIAQKQSMNESAHLGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQ 476
+E E L +LE+ +L D + E E A R ++E+E S++
Sbjct: 2210 QVE-------QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS-QVEEELFSVR 2261
Query: 477 STIQGLRDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLS---EE 533
++ L +E +K+N Q LQ + E+ KQ ++ LS +E
Sbjct: 2262 VQMEELSKLKARIEAENRALILRDKDNTQ-----RFLQEEAEKMKQVAEEAARLSVAAQE 2316
Query: 534 LIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENK 593
R ++ + D+ +A + +K+ M +++E +++ +EA + +KE
Sbjct: 2317 AARLRQLAEEDLAQQRALAEKMLKE----------KMQAVQEATRLKAEAELLQQQKEL- 2365
Query: 594 ALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQ-RLQEENGRLARKVT 652
A + +L+ +K Q+ + L + + +R + ER+ Q + E RL +V
Sbjct: 2366 --------AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2417
Query: 653 SLETATEKVE--ALEHESQGLQLENRTLRKSLDTLQNVSL-QLEGLERDNKQLDAENL-- 707
+ A + E A Q ++ + R L T + V+L Q ++R DAE L
Sbjct: 2418 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2477
Query: 708 ---ELRRLVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSV 764
EL R E ++ KL Q++ E Q ++++ L++ L ++ + + L + +
Sbjct: 2478 AIAELEREKEKLQ-QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI 2536
Query: 765 SAENLRLQQSLESSSHKTQTLESELG----ELEAERQALRRDLE-ALRLANAQLEGAEKD 819
E +L+Q + K Q L E ++E ERQ L +E A R + EG +
Sbjct: 2537 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2596
Query: 820 RKALEQEVAQLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARC 879
++ L+Q Q + ++LL +E +RL +Q++L + + A V A K L
Sbjct: 2597 QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNG 2656
Query: 880 RDAA-GKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSS--ELDKLSQELE 936
RDA G E E ++ + LR + ++L+ + S EL +L+Q
Sbjct: 2657 RDALDGPAAEAEPEH------------SFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2704
Query: 937 KVGLNRELLLQED-----DSGSDTKYKILEGRNE-----SALKTTLAMKEEKIVLLEAQ 985
V EL +ED S +L+ NE +AL+ L ++LLEAQ
Sbjct: 2705 TVD---ELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQ 2760
Score = 60.1 bits (144), Expect = 2e-08
Identities = 210/986 (21%), Positives = 366/986 (37%), Gaps = 189/986 (19%)
Query: 490 EESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSDMETLK 549
EE G + + L +LE +++ ++L+ + L+RE + +E+ +
Sbjct: 665 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 724
Query: 550 ADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQ---TVTEANGKL 606
A Q WS + EA +K EN A Q V EA G+L
Sbjct: 725 AALQTQ---------------WSWMLQLCCCIEAHLK----ENAAYFQFFSDVREAEGQL 765
Query: 607 SQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGRL-------------ARKVTS 653
+L+ R+ + + ++ +LE LQ Q+E +L A+ V
Sbjct: 766 QKLQEALRRKY-----SCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQ 820
Query: 654 LETAT-----------------EKVEALEHESQGLQLENRTLRKSLDTLQNVSLQL---- 692
L+ ++VE H+ QL L + +
Sbjct: 821 LKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPS 880
Query: 693 ---------EGLERDNKQLDAENLELRRLVETMRFTSTKLAQMERENQQLEREKEELRK- 742
+ + +L+A++ L L + L Q L R+ + +R
Sbjct: 881 VCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAW----QSLRRDVQLIRSW 936
Query: 743 NVDLLKALGKKSER-----LELSYQSVSAEN-----------LRLQQSLESSSHKTQTLE 786
++ + L + +R LEL YQ+ ++ L ++ S SH Q L
Sbjct: 937 SLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLL 996
Query: 787 SELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQ 846
L + E +R + L+ QLE E +L DK+ + A+R+ +
Sbjct: 997 QSLEQGAQEESRCQRCISELKDIRLQLEACE----TRTVHRLRLPLDKEPARECAQRIAE 1052
Query: 847 QVELKDAV--LDDSTAKLSAVEKESRALDKELARCRDAAGKLK-ELEKDNRDLTKQVTVH 903
Q + + V L A+LSA ++ AL + AA L+ ELE LT
Sbjct: 1053 QQKAQAEVEGLGKGVARLSAEAEKVLALPEP----SPAAPTLRSELE-----LTLGKLEQ 1103
Query: 904 ARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDS---------GSD 954
R+L+ + LEKLK+ L + + +Q E+V E L+E + +
Sbjct: 1104 VRSLSA----IYLEKLKTISL---VIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK 1156
Query: 955 TKYKILEGRNESALKTTLAMKEE-------KIVLLEAQMEEKASLNRQLESELQMLKKEC 1007
K L + E+ T A+++E L + E + R E Q+L++
Sbjct: 1157 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1216
Query: 1008 ETLRQ---NQGEGQHLQNSFKH------PAG---KTAASHQGK-EAWGPGHKEATMELLR 1054
L Q Q E + L ++ P G + A Q + +A +A E LR
Sbjct: 1217 AVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLR 1276
Query: 1055 VKDRAI-ELERNNAALQAEKQLLKEQLQHL---ETQNVTFSSQI--LTLQKQSAFLQEHN 1108
+ + E+ER+ ++ ++ K+ + + E Q VT+ +Q+ + + +Q +
Sbjct: 1277 QEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1336
Query: 1109 TTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETENESLQRQQ----EQLTAAY 1164
++ + L+ S L++ LT+QY + + E E L QQ + A
Sbjct: 1337 ESVIQEYVDLRTHYSELTT----LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1392
Query: 1165 EALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAELE 1224
EA L+ L H + A+ E K L + ++ E E D ++K ++
Sbjct: 1393 EAALEKQRQLAEAHAQAKAQAERE------AKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1446
Query: 1225 EREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQL----------KGEYEE 1274
E + L EA Q + A A E RLR E + + + QL +GE +
Sbjct: 1447 EELQQLRQSSEAEIQAKARQAEA-AERSRLRIE-EEIRVVRLQLEATERQRGGAEGELQA 1504
Query: 1275 LHAHTKELKTSLNNAQLELNRWQARFDELKEQHQTMDISLTKLDNHCELLSRLKGNLEEE 1334
L A +E + AQ E R + Q D S K EL SR+K E
Sbjct: 1505 LRARAEEAEAQKRQAQEEAERL---------RRQVQDESQRKRQAEVELASRVKAEAEAA 1555
Query: 1335 NH-----HLLSQIQLLSQQNQMLLEQ 1355
L +++L +++ + L Q
Sbjct: 1556 REKQRALQALEELRLQAEEAERRLRQ 1581
Score = 41.2 bits (95), Expect = 0.010
Identities = 95/403 (23%), Positives = 166/403 (41%), Gaps = 61/403 (15%)
Query: 519 REKQSNQDLETLSEELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQ 578
R S +++E L + ++ KE ++ +ADK R K + Q + +A + +
Sbjct: 333 RFPSSFEEIEILWSQFLKFKEM---ELPAKEADKNRS-KGIYQSLEGAVQA-----GQLK 383
Query: 579 VSSEARMKDVEKENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQ 638
V DVEKE LH + LE EK Q + + ER E L+R +
Sbjct: 384 VPPGYHPLDVEKEWGKLHVAI---------LEREK--------QLRSEFERLECLQRIVT 426
Query: 639 RLQEENGRLARKVTSLET-------------ATEKVEALEHESQGLQLENRTLRKSLDTL 685
+LQ E G ++ + ++ +E + R L + TL
Sbjct: 427 KLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTL 486
Query: 686 QN-VSLQLEGLERDNKQLDAENLELR-----RLVETMRFTSTKLAQMERENQQLEREKEE 739
++ Q E + R +L + +R RL + +T++AQ+ ++ Q E E+
Sbjct: 487 KDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELED 546
Query: 740 --LRKNVDLLKALGKKSERLE-----LSYQSVSAE---NLRLQQSLESSSHKTQTLESEL 789
LR DLL + + R++ + SV A+ + L QS+E K + S+
Sbjct: 547 STLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDE 606
Query: 790 GELE-AERQALRRDLEALRLANAQLEGAEKDR----KALEQEVAQLEKDKKLL-EKEAKR 843
G+L A R A R L L L A+L + K R ++L VA K+ L EKE +
Sbjct: 607 GQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEE 666
Query: 844 LWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKL 886
+ ++ + SA+ +E +K++ ++A +L
Sbjct: 667 VGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRL 709
Score = 39.7 bits (91), Expect = 0.030
Identities = 160/919 (17%), Positives = 365/919 (39%), Gaps = 102/919 (11%)
Query: 614 RQLHRDLEQAKEKGERAEKLERELQ-----RLQEENGRLARKVTS-LETATEKVEALEHE 667
R LH+ +E+ + K ERA E +L ++ GRL + L ++ ++ +LE
Sbjct: 586 RGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESL 645
Query: 668 SQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVETMRFTSTKLAQME 727
+ + L L+ + + + +R N + A+ L+ + K+ +++
Sbjct: 646 HSFVAAATKEL-MWLNEKEEEEVGFDWSDR-NTNMTAKKESYSALMRELELKEKKIKELQ 703
Query: 728 RENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSSHKTQTLES 787
+L RE R V+ +A + Q L+++ + E+
Sbjct: 704 NAGDRLLREDHPARPTVESFQA--ALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREA 761
Query: 788 ELGELEAERQALRRDLEALRLAN-AQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQ 846
E G+L+ ++ALRR R A +LE +D + E QL + K L AKR
Sbjct: 762 E-GQLQKLQEALRRKYSCDRSATVTRLEDLLQD---AQDEKEQLNEYKGHLSGLAKRAKA 817
Query: 847 QVELKD--------------AVLD----------------------------DSTAKLSA 864
V+LK AV D S+ +A
Sbjct: 818 VVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAA 877
Query: 865 VEKESRALDKELARCRDAAGKLKELEKDNRDLTKQVTVHARTL---TTLREDLVLEKLKS 921
V + ++A +L+ + L Q+ V ++L +LR D+ L ++S
Sbjct: 878 VPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQL--IRS 935
Query: 922 QQLSS----ELDKLSQELEKVGLNRELLLQ--EDDSGSDTKYKILEGRNESALKTTLAMK 975
L++ + ++ Q L + L+ + L+ +D G + +++ R +
Sbjct: 936 WSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHY--- 992
Query: 976 EEKIVLLEAQMEEKASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTA--- 1032
++ + LE +E++ R + SEL+ ++ + E L K PA + A
Sbjct: 993 QQLLQSLEQGAQEESRCQRCI-SELKDIRLQLEACETRTVHRLRLPLD-KEPARECAQRI 1050
Query: 1033 ASHQGKEAWGPGHKEATMELLRVKDRAIELERNNAA---LQAEKQLLKEQLQHLETQNVT 1089
A Q +A G + L ++ + L + A L++E +L +L+ + + +
Sbjct: 1051 AEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1110
Query: 1090 FSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETE 1149
+ ++ T+ Q L+ +L+ E + + L A L+ E +
Sbjct: 1111 YLEKLKTISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKASLKKLRAQAEAQ 1169
Query: 1150 NESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKEL 1209
+ +++L A E E L H + E E R+ L ++
Sbjct: 1170 QPTFDALRDELRGAQEV----GERLQQRHGERDVEVERW-RERVAQLLERWQAVLAQTDV 1224
Query: 1210 GERHGDMLKRKAEL--EEREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQ 1267
+R + L R+ E + + ++A +++++ A+ + ++Q +R +L + L +
Sbjct: 1225 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1284
Query: 1268 LK--GE-YEELHAHTKELKTSLNNAQLELNRWQARFDEL---KEQHQTMDISLTKLDNHC 1321
++ GE EE K+ ++ + +L+L ++A+ + + ++ + S + + +
Sbjct: 1285 IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYV 1344
Query: 1322 EL---LSRLKGNLEEENHHLLSQIQLLSQQNQMLLEQNMENKEQYHE-----EQKQYIDK 1373
+L S L + + ++ + ++ ++ +Q E +E+ E E+++ + +
Sbjct: 1345 DLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAE 1404
Query: 1374 LNALRRHKEKLEEKIMDQYKFYDPPPKKKNHWIGAKALVKLIKPKKEGSRERLKSTVDSP 1433
+A + + + E K + Q + + +++ + A+ + I+ + + R+ ++ + +
Sbjct: 1405 AHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1463
Query: 1434 PWQLESSDPASPAASQPLR 1452
Q E+++ + + +R
Sbjct: 1464 ARQAEAAERSRLRIEEEIR 1482
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 168 bits (425), Expect = 6e-41
Identities = 261/1214 (21%), Positives = 496/1214 (40%), Gaps = 176/1214 (14%)
Query: 235 DSTPSPTSSLSSEDKQHLAVELADTK----ARLRRVRQELEDKTEQLVDTRHEVD---QL 287
DS LSS D H + TK A L + +E+ D+ + TR + QL
Sbjct: 739 DSRKGTEKLLSSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRIITRMQAQARGQL 798
Query: 288 V-LELQKVKQENIQLAADARSARAYRD--------------ELDSLREKANRVERLELEL 332
+ +E +K+ + L + RA+ L E + ++ E
Sbjct: 799 MRIEFKKIVERRDALLVIQWNIRAFMGVKNWPWMKLYFKIKPLLKSAETEKEMATMKEEF 858
Query: 333 TRCKEKLHDVDFYKARMEELREDNIILIETKAMLEEQLTAARAR----GDKVHELEKENL 388
R KE L + AR +EL E + L++ K L+ Q+ A + ++ +L K +
Sbjct: 859 GRIKETLEKSE---ARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKI 915
Query: 389 QLKSKLHDLELDRDTDKKRIEELLEENMVLEIAQKQSMNESAHLGWELEQLSKNADLSDA 448
QL++K+ ++ + +++ EL + LE + + L L ++ K ++
Sbjct: 916 QLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATEN 975
Query: 449 SRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASLVLEESGLKCGELEKENHQLSK 508
K+ E+ I KL KE ++LQ Q D V E+ K L K +L +
Sbjct: 976 KVKNLTEEMAGL-DEIIAKLTKEKKALQEAHQQALDDLQVEED---KVNSLSKSKVKLEQ 1031
Query: 509 KIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNR 568
+++ L+ LE+EK+ DLE +L + + Q + L+ DK + + L++++ +N+
Sbjct: 1032 QVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQ 1091
Query: 569 ------------------------AMWSLRERSQVSSEARMK------DVEKENKALHQT 598
+ L E + AR K D+ +E + + +
Sbjct: 1092 QNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISER 1151
Query: 599 VTEANGKLS-QLEFEKR------QLHRDLEQA-------------------KEKGERAEK 632
+ EA G S Q+E K+ ++ RDLE+A E GE+ +
Sbjct: 1152 LEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDN 1211
Query: 633 LERELQRLQEENGRLARKVTSLETATEKVEALEHESQGLQLENRTLRKSLD----TLQNV 688
L+R Q+L++E L+ T +E + L+ +RTL + L+
Sbjct: 1212 LQRVKQKLEKEKSEFK---LELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEA 1268
Query: 689 SLQLEGLERDNKQLDAENLELRRLVE-----TMRFTSTKLA---QMERENQQLEREKEEL 740
L +L EN EL R +E + T KL+ QME +QLE E +
Sbjct: 1269 QRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAK 1328
Query: 741 RKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSS---------HKTQTLESELGE 791
L++ + L Y+ + LQ+ L ++ ++T ++ E
Sbjct: 1329 NALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQ-RTEE 1387
Query: 792 LEAERQALRRDL----EALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQQ 847
LE ++ L + L EA+ NA+ EK + L+ E+ L D + A L ++
Sbjct: 1388 LEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKK 1447
Query: 848 VELKDAVL-------DDSTAKLSAVEKESRALDKELARCRDAAGK----LKELEKDNRDL 896
D +L ++S ++L + +KE+R+L EL + ++A + L+ +++N++L
Sbjct: 1448 QRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNL 1507
Query: 897 TKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSD-T 955
++++ DL + + + EL+K+ ++LE L + L+E ++ +
Sbjct: 1508 QEEIS-----------DLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHE 1556
Query: 956 KYKILEGRNE-----SALKTTLAMKEEKIVLLEAQMEEKA-SLNRQLESELQMLKKECET 1009
+ KIL + E + ++ LA K+E++ + + SL L++E + +
Sbjct: 1557 EGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRV 1616
Query: 1010 LRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEATMEL---LRVKDRAIE----L 1062
++ +G+ ++ H A + + ++ K+ ++L +R D E +
Sbjct: 1617 KKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIV 1676
Query: 1063 ERNNAALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEHNTTLQTQTAKL---- 1118
ER N LQAE + L+ ++ E +++ ++ L NT+L Q K+
Sbjct: 1677 ERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDL 1736
Query: 1119 -----QVENSTLSSQSAALTAQYTLLQNHHTAKETENE-SLQRQQEQLTAAYEALLQDHE 1172
+VE + ++A A+ + A+E + E E++ E ++D +
Sbjct: 1737 TQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQ 1796
Query: 1173 HLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAELEEREKVLTT 1232
H L E + + +Q L+ R LE E + +R+ + +K + E R K LT
Sbjct: 1797 H--RLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKELTY 1854
Query: 1233 EREALQQEQRTNALAMGENQRLRGELDRVNFLHHQLKGEYEELHAHTKELKTSLNNAQLE 1292
+ E E + N L RL+ +D++ K + EE + Q E
Sbjct: 1855 QTE----EDKKNLL------RLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHE 1904
Query: 1293 LNRWQARFDELKEQ 1306
L+ + R D + Q
Sbjct: 1905 LDEAEERADIAESQ 1918
Score = 160 bits (406), Expect = 9e-39
Identities = 223/1007 (22%), Positives = 423/1007 (42%), Gaps = 129/1007 (12%)
Query: 424 QSMNESAHLGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLR 483
++ E A + E ++ + + S+A RK EL E +++ L +E LQ +Q +
Sbjct: 846 ETEKEMATMKEEFGRIKETLEKSEARRK----ELEE----KMVSLLQEKNDLQLQVQAEQ 897
Query: 484 DASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQS 543
D L ++ +C +L K QL K++++ +LE E++ N +L +L E +L+
Sbjct: 898 DN---LNDAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKK 954
Query: 544 DMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEA- 602
D++ L+ A+ +E+EK + +L E E K + KE KAL + +A
Sbjct: 955 DIDDLELTLAK----VEKEKHATENKVKNLTEEMAGLDEIIAK-LTKEKKALQEAHQQAL 1009
Query: 603 ------NGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGRLARKVTS-LE 655
K++ L K +L + ++ + E+ +K+ +L+R + RK+ L+
Sbjct: 1010 DDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAK-------RKLEGDLK 1062
Query: 656 TATEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVET 715
E + LE++ LQLE + +K D + + N +++ E + +L +
Sbjct: 1063 LTQESIMDLENDK--LQLEEKLKKKEFD-----------INQQNSKIEDEQVLALQLQKK 1109
Query: 716 MRFTSTKLAQMERENQQLEREKEELRK-NVDLLKALGKKSERLELSYQSVSAENLRLQQS 774
++ ++ ++E E + + ++ K DL + L + SERLE ++ A +++++ +
Sbjct: 1110 LKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLE---EAGGATSVQIEMN 1166
Query: 775 LESSSHKTQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKA-----LEQEVAQ 829
+ EAE Q +RRDLE L + A + + A L +++
Sbjct: 1167 KKR---------------EAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDN 1211
Query: 830 LEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLK-E 888
L++ K+ LEKE + LDD T+ + + K L+K D A + + +
Sbjct: 1212 LQRVKQKLEKEKSEFKLE-------LDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVK 1264
Query: 889 LEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELD--KLSQELEKVGLNRELLL 946
LE+ R L T A+ L T +L + + + L S+L KLS + L R+L
Sbjct: 1265 LEEAQRSLNDFTTQRAK-LQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQL-- 1321
Query: 947 QEDDSGSDTKYKILEGRNESALKTTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLKKE 1006
E+ EG+ ++AL L LL Q EE+ +L+ L E
Sbjct: 1322 -EE-----------EGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSE 1369
Query: 1007 CETLRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEATMELLRVKDRAIELERNN 1066
R E +Q +T + K+ ++A + V + LE+
Sbjct: 1370 VAQWRTKY-ETDAIQ--------RTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTK 1420
Query: 1067 AALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLS 1126
LQ E + L ++ + K A ++ Q++ Q E +LS
Sbjct: 1421 HRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLS 1480
Query: 1127 SQSAALTAQYTLLQNHHTAKETENESLQRQQEQLTAAYEALLQDHEHLGTLHE-RQSAEY 1185
++ L Y H + EN++LQ + LT E L + +++ L + R+ E
Sbjct: 1481 TELFKLKNAYEESLEHLETFKRENKNLQEEISDLT---EQLGEGGKNVHELEKVRKQLEV 1537
Query: 1186 EALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAELEER---------------EKVL 1230
E L Q S L+ +LE E ++ + + KAE+E + ++V+
Sbjct: 1538 EKLELQ-SALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVV 1596
Query: 1231 TTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQLKGEYEELHAHTKELKTSLNNAQ 1290
+ + +L E R+ + +++ G+L+ + E K L++ L + Q
Sbjct: 1597 DSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQ 1656
Query: 1291 LELNRWQARFDELKE-------QHQTMDISLTKLDNHCELLSRLKGNLEEENHHLLSQIQ 1343
++L+ D+LKE ++ + L +L E R + E+E ++Q
Sbjct: 1657 IQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQ 1716
Query: 1344 LLSQQNQMLLEQNMENKEQYHEEQKQYIDKLNALRRHKEKLEEKIMD 1390
LL QN L+ Q + + + Q + + + R +EK ++ I D
Sbjct: 1717 LLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITD 1763
Score = 141 bits (355), Expect = 7e-33
Identities = 239/1078 (22%), Positives = 455/1078 (42%), Gaps = 141/1078 (13%)
Query: 132 VQCERK-EEFIERIKQLDIETQAGIVAHIQEVTHN-QENVFDLQWLELPDVAPEELEALS 189
+Q E K +E ER++ + E A + A +++ E D+ LEL E+ + +
Sbjct: 915 IQLEAKVKEMNERLEDEE-EMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHAT 973
Query: 190 RSMVLHLRRLIDQRDECTELIVDLTQERDYLQAQHPPSPIKSSSADSTPSPTSSLSSEDK 249
+ V + L ++ E+I LT+E+ LQ H + D EDK
Sbjct: 974 ENKV---KNLTEEMAGLDEIIAKLTKEKKALQEAH------QQALDDLQ------VEEDK 1018
Query: 250 QHLAVELADTKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQ---KVKQENIQLAADAR 306
+ L+ +K +L + +LE EQ R ++++ +L+ K+ QE+I D
Sbjct: 1019 VN---SLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIM---DLE 1072
Query: 307 SARAYRDELDSLREKANRVERLELELTRCKEKLHDVDFYKARMEELREDNIILIETKAML 366
+ + +E ++++ E ++ + K+ D ++++ ++N IE L
Sbjct: 1073 NDKLQLEE---------KLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEE---L 1120
Query: 367 EEQLTAARA--------RGDKVHELEKENLQLKSKLHDLELDRDTDKKRIEELLEENMVL 418
EE+L A R R D ELE+ + +L+ + + +KKR E + L
Sbjct: 1121 EEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDL 1180
Query: 419 EIA-----------QKQSMNESAHLGWELEQLSKNADLSDASRKSFVFELNECASS--RI 465
E A +K+ + A LG +++ L + + + F EL++ S+ +I
Sbjct: 1181 EEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQI 1240
Query: 466 LK----LEKENQSLQSTIQ----GLRDASLVLEESGLKCGELEKENHQLSKKIEK---LQ 514
+K LEK +++L+ L +A L + + +L+ EN +L++++E+ L
Sbjct: 1241 IKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALI 1300
Query: 515 TQLEREK----QSNQDLETLSEELIREKEQLQSDMETLKAD---KARQIKDLEQEKDHLN 567
+QL R K Q +DL+ EE + K L +++ + D Q ++ + K L
Sbjct: 1301 SQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQ 1360
Query: 568 R---------AMWSLRERSQVSSEARMKDVEKENKALHQTVTEA-------NGKLSQLEF 611
R A W R + + + R +++E+ K L Q + +A N K S LE
Sbjct: 1361 RVLSKANSEVAQW--RTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEK 1418
Query: 612 EKRQLHRDLEQAKEKGERAEKLERELQRLQEENGRLARKVTSLETATEKVEALEHESQGL 671
K +L ++E ER+ L + Q ++ L +K E + E +
Sbjct: 1419 TKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKI------LAEWKQKYEESQSELESS 1472
Query: 672 QLENRTLRKSLDTLQNV---SLQ-LEGLERDNKQLDAENLELRRLVETMRFTSTKLAQME 727
Q E R+L L L+N SL+ LE +R+NK L E+ L E + + ++E
Sbjct: 1473 QKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQE---EISDLTEQLGEGGKNVHELE 1529
Query: 728 RENQQLEREKEELRKNVDLLKALGKKSE----RLELSYQSVSAENLRL-----QQSLESS 778
+ +QLE EK EL+ ++ +A + E R +L + + AE R ++ ++
Sbjct: 1530 KVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAK 1589
Query: 779 SHKTQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLE 838
+ + ++S L+AE ++ L + L E + A+ +K K L+
Sbjct: 1590 RNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQ 1649
Query: 839 KEAKRLWQQVELKDAVL--DDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDNRDL 896
K Q++L DAV DD ++ VE+ + L EL R + + K
Sbjct: 1650 SLLKD--TQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQE 1707
Query: 897 TKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSDTK 956
+ + + L + L+ +K K + S+L +L E+E+ +QE + +
Sbjct: 1708 LIETSERVQLLHSQNTSLINQKKK---MESDLTQLQSEVEEA-------VQECRNAEEKA 1757
Query: 957 YKILEGRNESALKTTLAMKEE----KIVLLEAQMEE--KASLNRQLESELQMLKKECETL 1010
K + ++A+ KE+ + ++ ME+ K +R E+E LK + L
Sbjct: 1758 KKAI---TDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQL 1814
Query: 1011 RQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEATMELLRVKDRAIELERNNAALQ 1070
++ + + L+ + + A S +G KE T + K + L+ LQ
Sbjct: 1815 QKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLLRLQDLVDKLQ 1874
Query: 1071 AEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQ 1128
+ + K Q + E Q T S+ +Q + +E ++Q KL+ ++ + ++
Sbjct: 1875 LKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIGAK 1932
Score = 126 bits (317), Expect = 2e-28
Identities = 191/928 (20%), Positives = 396/928 (42%), Gaps = 128/928 (13%)
Query: 136 RKEEFIERIKQLDIETQAGIVAHIQE-VTHNQENVFDLQW-LELPDVAPEELEALSRSMV 193
+K+EF + IE + + +Q+ + NQ + +L+ LE A ++E L +
Sbjct: 1083 KKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLS 1142
Query: 194 LHLRRLIDQRDEC---TELIVDLTQERDYLQAQHPPSPIKSSSADSTPSPTSSLSSEDKQ 250
L + ++ +E T + +++ ++R+ A+ ++ ++T ++ ++ K+
Sbjct: 1143 RELEEISERLEEAGGATSVQIEMNKKRE---AEF--QKMRRDLEEATLQHEATAAALRKK 1197
Query: 251 HL--AVELADTKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSA 308
H EL + L+RV+Q+LE + + + E+D + ++++ + L + +
Sbjct: 1198 HADSVAELGEQIDNLQRVKQKLEKEKSEF---KLELDDVTSNMEQIIKAKANLE---KVS 1251
Query: 309 RAYRDELDSLREKANRVERLELELTRCKEKLHDVDFYKARMEELREDNIILIETKAMLEE 368
R D+ + R K +R + T + KL + AR E +E I +
Sbjct: 1252 RTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALI-----SQLTRG 1306
Query: 369 QLTAARARGDKVHELEKENLQLKSKLHDLELDR---DTDKKRIEELLEENMVLEIAQKQS 425
+L+ + D +LE+E + H L+ R D +++ EE E L+ ++
Sbjct: 1307 KLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKA 1366
Query: 426 MNESAH--LGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLR 483
+E A +E + + + +L +A +K Q L+
Sbjct: 1367 NSEVAQWRTKYETDAIQRTEELEEAKKK--------------------------LAQRLQ 1400
Query: 484 DASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQS 543
DA +E KC LEK H+L +IE L +ER + L+ R +++ +
Sbjct: 1401 DAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQ----RNFDKILA 1456
Query: 544 DMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEAN 603
+ + + +++ ++E L+ ++ L+ + S E ++ ++ENK L + +++
Sbjct: 1457 EWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLE-HLETFKRENKNLQEEISDLT 1515
Query: 604 GKL--------------SQLEFEKRQLHRDLEQAKEKGERAE---------------KLE 634
+L QLE EK +L LE+A+ E E ++E
Sbjct: 1516 EQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIE 1575
Query: 635 RELQRLQEENGRLARK----VTSLETATEKVEALEHESQGLQLENRTLRKSLDTLQNVSL 690
R+L EE + R V SL+T +L+ E++ R +K L + +
Sbjct: 1576 RKLAEKDEEMEQAKRNHQRVVDSLQT------SLDAETRSRNEVLRVKKKMEGDLNEMEI 1629
Query: 691 QLEGLERDNKQLDAENLELRRLVETMRF-----------TSTKLAQMERENQQLEREKEE 739
QL R + + L+ L++ + +A +ER N L+ E EE
Sbjct: 1630 QLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEE 1689
Query: 740 LRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSSHKTQTLESELGELEAERQAL 799
LR V+ + K +E+ EL S + L Q + S ++ + +ES+L +L++E +
Sbjct: 1690 LRAVVEQTERSRKLAEQ-ELIETSERVQLLHSQNT--SLINQKKKMESDLTQLQSE---V 1743
Query: 800 RRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQQVELKDAVLDDST 859
++ R A + + A D + +E+ + + LE+ K + Q ++ LD+
Sbjct: 1744 EEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDE-- 1801
Query: 860 AKLSAVEKESRALDKELARCRDAAGKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKL 919
A+ A++ + L K AR R+ G+L+ +K N + K + R + L +K
Sbjct: 1802 AEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKK 1861
Query: 920 KSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSD-TKYKILEGRNESALKTTLAMKEEK 978
+L +DKL +L+ R+ E+ + ++ +K++ ++ + A EE+
Sbjct: 1862 NLLRLQDLVDKL--QLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEA--------EER 1911
Query: 979 IVLLEAQMEEKASLNRQLESELQMLKKE 1006
+ E+Q+ + + +R + ++ +M +E
Sbjct: 1912 ADIAESQVNKLRAKSRDIGAKQKMHDEE 1939
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 167 bits (422), Expect = 1e-40
Identities = 258/1214 (21%), Positives = 498/1214 (41%), Gaps = 176/1214 (14%)
Query: 235 DSTPSPTSSLSSEDKQHLAVELADTK----ARLRRVRQELEDKTEQLVDTRHEVDQ---- 286
DS LSS D H + TK A L + +E+ D+ + TR +
Sbjct: 737 DSRKGAEKLLSSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRIITRIQAQSRGVL 796
Query: 287 LVLELQKVKQENIQLAADARSARAYRD--------------ELDSLREKANRVERLELEL 332
+E +K+ + L + RA+ L E+ + ++ E
Sbjct: 797 ARMEYKKLLERRDSLLVIQWNIRAFMGVKNWPWMKLYFKIKPLLKSAEREKEMASMKEEF 856
Query: 333 TRCKEKLHDVDFYKARMEELREDNIILIETKAMLEEQLTAARAR----GDKVHELEKENL 388
TR KE L + AR +EL E + L++ K L+ Q+ A + ++ +L K +
Sbjct: 857 TRLKEALEKSE---ARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKI 913
Query: 389 QLKSKLHDLELDRDTDKKRIEELLEENMVLEIAQKQSMNESAHLGWELEQLSKNADLSDA 448
QL++K+ ++ + +++ EL + LE + + L L ++ K ++
Sbjct: 914 QLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATEN 973
Query: 449 SRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASLVLEESGLKCGELEKENHQLSK 508
K+ E+ I KL KE ++LQ Q D L EE K L K +L +
Sbjct: 974 KVKNLTEEMAGL-DEIIAKLTKEKKALQEAHQQALD-DLQAEED--KVNTLTKAKVKLEQ 1029
Query: 509 KIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSDMETLKADKARQIKDLEQEKDHLN- 567
+++ L+ LE+EK+ DLE +L + + Q + L+ DK + + L+++ LN
Sbjct: 1030 QVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNA 1089
Query: 568 --------RAMWSLRERSQVSSEARMKDVEKENKA---------------------LHQT 598
+A+ S ++ +AR++++E+E +A + +
Sbjct: 1090 LNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISER 1149
Query: 599 VTEANGKLS-QLEFEKRQ------LHRDLEQAK-------------------EKGERAEK 632
+ EA G S Q+E K++ + RDLE+A E GE+ +
Sbjct: 1150 LEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDN 1209
Query: 633 LERELQRLQEENGRLARKVTSLETATEKVEALEHESQGLQLENRTLRKSLDT----LQNV 688
L+R Q+L++E + L+ T +E + L+ RTL ++ +
Sbjct: 1210 LQRVKQKLEKEKSEFKLE---LDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEET 1266
Query: 689 SLQLEGLERDNKQLDAENLELRRLVETMRFTSTKLA--------QMERENQQLEREKEEL 740
+ L +L EN EL R ++ ++L Q+E +QLE E +
Sbjct: 1267 QRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAK 1326
Query: 741 RKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSS---------HKTQTLESELGE 791
L++ + L Y+ + LQ+ L ++ ++T ++ E
Sbjct: 1327 NALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQ-RTEE 1385
Query: 792 LEAERQALRRDL----EALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQQ 847
LE ++ L + L EA+ NA+ EK + L+ E+ L D + A L ++
Sbjct: 1386 LEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKK 1445
Query: 848 VELKDAVL-------DDSTAKLSAVEKESRALDKELARCRDAAGK----LKELEKDNRDL 896
D +L ++S ++L + +KE+R+L EL + ++A + L+ +++N++L
Sbjct: 1446 QRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNL 1505
Query: 897 TKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSD-T 955
++++ DL + S + EL+K+ ++LE + + L+E ++ +
Sbjct: 1506 QEEIS-----------DLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHE 1554
Query: 956 KYKILEGRNE-----SALKTTLAMKEEKIVLLEA-QMEEKASLNRQLESELQMLKKECET 1009
+ KIL + E + ++ LA K+E++ + + SL L++E + +
Sbjct: 1555 EGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRV 1614
Query: 1010 LRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEATMEL---LRVKDRAIE----L 1062
++ +G+ ++ H A + + ++ K+ ++L +R D E +
Sbjct: 1615 KKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIV 1674
Query: 1063 ERNNAALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEHNTTLQTQTAKL---- 1118
ER N LQAE + L+ ++ E +++ ++ L NT+L Q K+
Sbjct: 1675 ERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADL 1734
Query: 1119 -----QVENSTLSSQSAALTAQYTLLQNHHTAKETENE-SLQRQQEQLTAAYEALLQDHE 1172
+VE + ++A A+ + A+E + E E++ E ++D +
Sbjct: 1735 SQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQ 1794
Query: 1173 HLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAELEEREKVLTT 1232
H L E + + +Q L+ R LE E + +R+ + +K + E R K LT
Sbjct: 1795 H--RLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTY 1852
Query: 1233 EREALQQEQRTNALAMGENQRLRGELDRVNFLHHQLKGEYEELHAHTKELKTSLNNAQLE 1292
+ E E R N L RL+ +D++ K + EE + Q E
Sbjct: 1853 QTE----EDRKNLL------RLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHE 1902
Query: 1293 LNRWQARFDELKEQ 1306
L+ + R D + Q
Sbjct: 1903 LDEAEERADIAESQ 1916
Score = 158 bits (399), Expect = 6e-38
Identities = 245/1092 (22%), Positives = 456/1092 (41%), Gaps = 131/1092 (11%)
Query: 340 HDVDFYKARM----EELREDNIILIETKAMLEEQLTAARARGDKVHELEKENLQLKSKLH 395
H F+KA + EE+R++ + I T+ + + AR K+ E L ++ +
Sbjct: 760 HTKVFFKAGLLGLLEEMRDERLSRIITRIQAQSRGVLARMEYKKLLERRDSLLVIQWNIR 819
Query: 396 DLELDRDTDKKRIEELLEENMVLEIAQKQSMNESAHLGWELEQLSKNADLSDASRKSFVF 455
++ ++ ++ +L+ A+++ E A + E +L + + S+A RK
Sbjct: 820 AFMGVKNWPWMKLYFKIKP--LLKSAEREK--EMASMKEEFTRLKEALEKSEARRK---- 871
Query: 456 ELNECASSRILKLEKENQSLQSTIQGLRDASLVLEESGLKCGELEKENHQLSKKIEKLQT 515
EL E +++ L +E LQ +Q +D EE +C +L K QL K++++
Sbjct: 872 ELEE----KMVSLLQEKNDLQLQVQAEQDNLADAEE---RCDQLIKNKIQLEAKVKEMNE 924
Query: 516 QLEREKQSNQDLETLSEELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRE 575
+LE E++ N +L +L E +L+ D++ L+ A+ +E+EK + +L E
Sbjct: 925 RLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAK----VEKEKHATENKVKNLTE 980
Query: 576 RSQVSSEARMKDVEKENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGER-AEKLE 634
E K + KE KAL + +A L L+ E+ +++ L +AK K E+ + LE
Sbjct: 981 EMAGLDEIIAK-LTKEKKALQEAHQQA---LDDLQAEEDKVNT-LTKAKVKLEQQVDDLE 1035
Query: 635 RELQRLQEENGRLARKVTSLETATEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEG 694
L+ QE+ R+ LE A K+E + + ++S+ L+N QL+
Sbjct: 1036 GSLE--QEKKVRM-----DLERAKRKLEG----------DLKLTQESIMDLENDKQQLD- 1077
Query: 695 LERDNKQLDAENLELRRLVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKS 754
++L ++ EL L + +Q++++ ++L+ EEL + ++ + K
Sbjct: 1078 -----ERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKV 1132
Query: 755 ERLELSYQSVSAENLRLQQSLESSSHKTQTLESELGELEAERQALRRDLEALRLANAQLE 814
E+L +S E + + LE + T + EAE Q +RRDLE L +
Sbjct: 1133 EKLR---SDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATA 1189
Query: 815 GAEKDRKA-----LEQEVAQLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKES 869
A + + A L +++ L++ K+ LEKE + LDD T+ + + K
Sbjct: 1190 AALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLE-------LDDVTSNMEQIIKAK 1242
Query: 870 RALDKELARCRDAAGKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELD 929
L+K CR ++ E +R ++ LT+ R L E + +LS +LD
Sbjct: 1243 ANLEK---MCRTLEDQMNE----HRSKAEETQRSVNDLTSQRAKLQTE---NGELSRQLD 1292
Query: 930 KLSQELEKVGLNRELLLQEDDSGSDTKYKILEG-RNESALKTTLAMKEEKIVLLEAQMEE 988
+ + ++ + Q+ + D K ++ E + ++AL L LL Q EE
Sbjct: 1293 EKEALISQLTRGKLTYTQQLE---DLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEE 1349
Query: 989 KASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEA 1048
+ +L+ L E R E +Q +T + K+ +EA
Sbjct: 1350 ETEAKAELQRVLSKANSEVAQWRTKY-ETDAIQ--------RTEELEEAKKKLAQRLQEA 1400
Query: 1049 TMELLRVKDRAIELERNNAALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEHN 1108
+ V + LE+ LQ E + L ++ + K A ++
Sbjct: 1401 EEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKY 1460
Query: 1109 TTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETENESLQRQQEQLTAAYEALL 1168
Q++ Q E +LS++ L Y H + EN++LQ + LT
Sbjct: 1461 EESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLT------- 1513
Query: 1169 QDHEHLG----TLHE----RQSAEYEALIRQHSCLKTLHRNLELEHKELGERHGDMLKRK 1220
E LG T+HE R+ E E + Q S L+ +LE E ++ + + K
Sbjct: 1514 ---EQLGSSGKTIHELEKVRKQLEAEKMELQ-SALEEAEASLEHEEGKILRAQLEFNQIK 1569
Query: 1221 AELEERE---------------KVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLH 1265
AE+E + +V+ + + +L E R+ A+ +++ G+L+ +
Sbjct: 1570 AEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQL 1629
Query: 1266 HQLKGEYEELHAHTKELKTSLNNAQLELNRWQARFDELKE-------QHQTMDISLTKLD 1318
E K L++ L + Q++L+ D+LKE ++ + L +L
Sbjct: 1630 SHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELR 1689
Query: 1319 NHCELLSRLKGNLEEENHHLLSQIQLLSQQNQMLLEQNMENKEQYHEEQKQYIDKLNALR 1378
E R + E+E ++QLL QN L+ Q + + Q + + + R
Sbjct: 1690 AVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECR 1749
Query: 1379 RHKEKLEEKIMD 1390
+EK ++ I D
Sbjct: 1750 NAEEKAKKAITD 1761
Score = 145 bits (367), Expect = 3e-34
Identities = 236/1068 (22%), Positives = 447/1068 (41%), Gaps = 121/1068 (11%)
Query: 132 VQCERK-EEFIERIKQLDIETQAGIVAHIQEVTHN-QENVFDLQWLELPDVAPEELEALS 189
+Q E K +E ER++ + E A + A +++ E D+ LEL E+ + +
Sbjct: 913 IQLEAKVKEMNERLEDEE-EMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHAT 971
Query: 190 RSMVLHLRRLIDQRDECTELIVDLTQERDYLQAQHPPSPIKSSSADSTPSPTSSLSSEDK 249
+ V + L ++ E+I LT+E+ LQ H + + A+ T + +
Sbjct: 972 ENKV---KNLTEEMAGLDEIIAKLTKEKKALQEAHQQA-LDDLQAEEDKVNTLTKAKVKL 1027
Query: 250 QHLAVELADTKARLRRVRQELEDKT-----------EQLVDTRHEVDQLVLELQKVKQEN 298
+ +L + + ++VR +LE E ++D ++ QL L+K E
Sbjct: 1028 EQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFEL 1087
Query: 299 IQLAADARSARAYRDELDS-LREKANRVERLELELTRCKEKLHDVDFYKARMEELREDNI 357
L A +A +L L+E R+E LE EL + +A++E+LR D
Sbjct: 1088 NALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTA-------RAKVEKLRSD-- 1138
Query: 358 ILIETKAMLEEQLTAARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIEELLEENMV 417
+ E + + E A A ++ +K + + DLE E L+
Sbjct: 1139 LSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLE----------EATLQHEAT 1188
Query: 418 LEIAQKQSMNESAHLGWELEQLSKNADLSDASRKSFVFELNECASS--RILK----LEKE 471
+K+ + A LG +++ L + + + F EL++ S+ +I+K LEK
Sbjct: 1189 AAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKM 1248
Query: 472 NQSLQSTIQGLRDASLVLEES----GLKCGELEKENHQLSKKI---EKLQTQLEREK--- 521
++L+ + R + + S + +L+ EN +LS+++ E L +QL R K
Sbjct: 1249 CRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTY 1308
Query: 522 -QSNQDLETLSEELIREKEQLQSDMETLKAD---KARQIKDLEQEKDHLNR--------- 568
Q +DL+ EE ++ K L +++ + D Q ++ + K L R
Sbjct: 1309 TQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEV 1368
Query: 569 AMWSLRERSQVSSEARMKDVEKENKALHQTVTEA-------NGKLSQLEFEKRQLHRDLE 621
A W R + + + R +++E+ K L Q + EA N K S LE K +L ++E
Sbjct: 1369 AQW--RTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIE 1426
Query: 622 QAKEKGERAEKLERELQRLQEENGRLARKVTSLETATEKVEALEHESQGLQLENRTLRKS 681
ER+ L + Q ++ L +K E + E + Q E R+L
Sbjct: 1427 DLMVDVERSNAAAAALDKKQRNFDKI------LAEWKQKYEESQSELESSQKEARSLSTE 1480
Query: 682 LDTLQNV---SLQ-LEGLERDNKQLDAENLELRRLVETMRFTSTKLAQMERENQQLEREK 737
L L+N SL+ LE +R+NK L E + L E + + + ++E+ +QLE EK
Sbjct: 1481 LFKLKNAYEESLEHLETFKRENKNLQEE---ISDLTEQLGSSGKTIHELEKVRKQLEAEK 1537
Query: 738 EELRKNVDLLKALGKKSE----RLELSYQSVSAENLRL-----QQSLESSSHKTQTLESE 788
EL+ ++ +A + E R +L + + AE R ++ ++ + + ++S
Sbjct: 1538 MELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSL 1597
Query: 789 LGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQQV 848
L+AE ++ L + L E + A+ +K K L+ K Q+
Sbjct: 1598 QTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDT--QI 1655
Query: 849 ELKDAVL--DDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDNRDLTKQVTVHART 906
+L DAV DD ++ VE+ + L EL R + + K + + +
Sbjct: 1656 QLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQL 1715
Query: 907 LTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSDTKYKILEGRNES 966
L + L+ +K K + ++L +L E+E+ +QE + + K + ++
Sbjct: 1716 LHSQNTSLINQKKK---MDADLSQLQTEVEEA-------VQECRNAEEKAKKAI---TDA 1762
Query: 967 ALKTTLAMKEEK----IVLLEAQMEE--KASLNRQLESELQMLKKECETLRQNQGEGQHL 1020
A+ KE+ + ++ ME+ K +R E+E LK + L++ + + L
Sbjct: 1763 AMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVREL 1822
Query: 1021 QNSFKHPAGKTAASHQGKEAWGPGHKEATMELLRVKDRAIELERNNAALQAEKQLLKEQL 1080
+N + + A S +G KE T + + + L+ LQ + + K Q
Sbjct: 1823 ENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQA 1882
Query: 1081 QHLETQNVTFSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQ 1128
+ E Q T S+ +Q + +E ++Q KL+ ++ + ++
Sbjct: 1883 EEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIGTK 1930
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 167 bits (422), Expect = 1e-40
Identities = 275/1246 (22%), Positives = 531/1246 (42%), Gaps = 159/1246 (12%)
Query: 256 LADTKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSARAYRDEL 315
+ D+ A L+ + Q+LE+ + + + D +Q+ QLA + ++ DE
Sbjct: 130 VTDSSAELQSLEQQLEEAQTENFNIKQMKDLF-------EQKAAQLATEIADIKSKYDEE 182
Query: 316 DSLREKA-NRVERLELELTR-------------CKEKLHDVDFYKARMEELRE--DNIIL 359
SLRE A +V RL EL + + + DV K + +++ DN+ L
Sbjct: 183 RSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTL 242
Query: 360 ---IETKAMLEE----------------QLTAARARGDKVHELEKENLQ-LKSKLHDLEL 399
E++ + +E QL + A+G + + + LQ LKS +++L
Sbjct: 243 ERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQ 302
Query: 400 DRDT------DKKRIEELLEENMVLEIAQKQSMNESAH-LGWELEQLSKNADLSDASRKS 452
T K++ LEE E K+++ + H + +QL S+ S
Sbjct: 303 KNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHR 362
Query: 453 FVFELNECASSRILKLEKENQSLQSTIQGLRDASLVLEESGLKCGELEKENH--QLSKKI 510
EL+E KL++E +++ Q L+ E L+ EKE H QL +I
Sbjct: 363 IHVELSE-KGEATQKLKEELSEVETKYQHLK-----AEFKQLQQQREEKEQHGLQLQSEI 416
Query: 511 EKLQTQ-LEREKQSNQDLETLSEELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRA 569
+L ++ LE E+Q L E R KEQ Q E L DK +Q+ DL+ + L+R
Sbjct: 417 NQLHSKLLETERQ-------LGEAHGRLKEQRQLSSEKL-MDKEQQVADLQLK---LSRL 465
Query: 570 MWSLRERSQVSSEA-----RMKDVEKENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAK 624
L+E+ S+E + K +E +AL Q+ T ++L + L + L Q
Sbjct: 466 EEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTT------AKLREAQNDLEQVLRQIG 519
Query: 625 EKGERAEKLERELQRLQEENGRLARKVTSLETATEKVEALEHESQGLQLENRTLRKSLDT 684
+K ++ + LE LQ+ +E L ++ L + E LQ +N TL++ +
Sbjct: 520 DKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQ 579
Query: 685 LQNVSLQLEGLERDNKQLDAENL--ELRRLVETMRFTSTKLAQMERENQQLEREKEELRK 742
L +L+ +KQ ENL +++ +R ++ +E +L + E ++
Sbjct: 580 LTE---KLKNQSESHKQAQ-ENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKE 635
Query: 743 NVDLLKALGKKSERLELSYQSV-SAENLRLQQSLESSSHKTQTLESELGELEAERQALRR 801
V L K L LS ++ +A+ LQ L+++ + Q + EL ++ + +
Sbjct: 636 KVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTA 695
Query: 802 DLEALRLANAQLEGAEKDRK----ALEQEVAQLEKDKKLLEKEA-------KRLWQQVEL 850
L+ + +QLE K+ K +LEQ+ +LE K LE ++ ++ Q ++
Sbjct: 696 KLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQ 755
Query: 851 KDAVLDDSTAKLSAVEKESRALDKELARCR--DAAGKLKELEKDNRDLTKQ---VTVHAR 905
+ + D + + + K+ ++KE+ D K + LE + LTKQ + +
Sbjct: 756 QRQLNTDLELRATELSKQLE-MEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQ 814
Query: 906 TLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSDTKYKILEGRNE 965
TL ++ K++ ++L++ + EL+KV + +E L+ E + D K+ +
Sbjct: 815 DFETLSQE---TKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKN 871
Query: 966 SAL-----------------KTTLAMKEEKIVLLEAQMEEKASLNRQLESELQ---MLKK 1005
S KT +K + V +E ++E+ L + LE E + LK
Sbjct: 872 SKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKL 931
Query: 1006 EC-----------ETLRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEATMELLR 1054
E TL+QN+ E Q LQ + + + EA K A ++
Sbjct: 932 ELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTE 991
Query: 1055 VKDRAIELERNNAA--LQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEHNTTLQ 1112
++++ ++ + AA L AEK+ + + E TF + + L L+
Sbjct: 992 LENK-LQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLK 1050
Query: 1113 TQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETENESLQRQQEQLTAAYEALLQDHE 1172
+ KL + L S + Q L+Q TAK T + ++++QL +A LQD +
Sbjct: 1051 SVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKA-LQDIQ 1109
Query: 1173 HLGTLHERQSAEYEALIRQHSCLK-TLHRNLELEHKELGERHGDMLKRKAELEEREKVLT 1231
+L E++ ++ + + +K + + ++EL + +K L++ +++L
Sbjct: 1110 KEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLI 1169
Query: 1232 TEREALQQEQRTNALAMGENQRLRGEL-DRVNFLHHQLKGEYEELHAHTKELKTSLNNAQ 1290
++ LQ + + A+ + +R + L D+V +LK E+ E A +L + + +
Sbjct: 1170 QQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEA---KLHSEIKEKE 1226
Query: 1291 LELNRWQARFDELKEQHQTMDISLTKLDNHCELLSRLKGNLEEENHHLLSQIQLLSQQNQ 1350
+ + + + +L Q ++ +L + + R LE++ L +I
Sbjct: 1227 VGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEI-------- 1278
Query: 1351 MLLEQNMENKEQYHEEQKQYIDKLNALRRHKEKLEEKIMDQYKFYD 1396
+LE ++N + +E++ +++ EKL+ K+++ + D
Sbjct: 1279 AVLEATVQNNQ---DERRALLERCLKGEGEIEKLQTKVLELQRKLD 1321
Score = 164 bits (415), Expect = 8e-40
Identities = 218/1054 (20%), Positives = 468/1054 (44%), Gaps = 105/1054 (9%)
Query: 184 ELEALSRSMVLHLRRLIDQRDECTELIVDLTQERDYLQAQHPPSPIKSSSADSTPSPTSS 243
E+E + + ++L QR+E + + L E + L ++ + + A
Sbjct: 383 EVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQ 442
Query: 244 LSSEDKQHLAVELADTKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQKVKQENIQLAA 303
LSSE ++AD + +L R+ ++L++K + +H++D+ + Q +Q+ +Q +
Sbjct: 443 LSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDK--TKQQHQEQQALQQST 500
Query: 304 DARSARAYRDELDSLR---EKANRVERLELELTRCKEKLHDVDFYKARMEELREDNIILI 360
A+ A D LR +K +++ LE L + KE + + +E+ RED I
Sbjct: 501 TAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENI-------SLLEKEREDLYAKI 553
Query: 361 ETKAMLEEQLTAARARGDKVHELEKENLQLKSKL-HDLELDRDTDKKRIEELLEENMVLE 419
+ E + +K H L+++ QL KL + E + + +++ E+ L
Sbjct: 554 QAG---EGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLR 610
Query: 420 IAQKQSMNESAHLGWELEQLSKNADLSDASRKSFVFELN-ECASSRILKLEKENQSLQST 478
AQ + L E N+ L+++ K ++ + + +L E + ++
Sbjct: 611 AAQDRV------LSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRAD 664
Query: 479 IQG-LRDASLVLEESGLKCGELEKENHQLSKKIE-------KLQTQLEREKQSNQDLETL 530
+Q L A L++ + ++ + Q++ K++ +L++ L+ K+ LE
Sbjct: 665 LQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQK 724
Query: 531 SEELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEK 590
+EEL + ++L++D +KA K + ++DL+Q++ L ++ + K +E
Sbjct: 725 TEELEGQIKKLEADSLEVKASKEQALQDLQQQR--------QLNTDLELRATELSKQLEM 776
Query: 591 ENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEE-NGRLAR 649
E + + T + K LE K++L + E+ + + E L +E + EE N R+
Sbjct: 777 EKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQT 836
Query: 650 KVTSLETATEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLEL 709
VT L+ + EAL E L L K D+L+N + E++N++ A L+L
Sbjct: 837 TVTELQKVKMEKEALMTE---LSTVKDKLSKVSDSLKNSKSE---FEKENQKGKAAILDL 890
Query: 710 RRLVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENL 769
+ + ++ Q++ + + +E++EL+K+++ K + S +L+L S+ + +
Sbjct: 891 EKTCKELKH------QLQVQMENTLKEQKELKKSLEKEK---EASHQLKLELNSMQEQLI 941
Query: 770 RLQQSLESSSHKTQTLESELGELEAERQALRRDLEALR------------LAN---AQLE 814
+ Q +L+ + + Q L+ + EL+ + ++ +EAL+ L N QL
Sbjct: 942 QAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLT 1001
Query: 815 GAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDK 874
A ++ A +++++ L+ + + ++ K+L +++ L + L +VE++ +
Sbjct: 1002 QAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQE 1061
Query: 875 ELARCRDAAGKLKE-----------LEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQ 923
+L R+ G + LE+D+ +Q+ + L ++++ + LK ++
Sbjct: 1062 DLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKE---KSLKEKE 1118
Query: 924 LSSELDKLSQELEKVGLNRELLLQEDDSGSDTKYKILEGRNESALKTTLAMKEEKIVLLE 983
L +E KL+ E+E++ +E + + + + L+ ++K +K+ K +L++
Sbjct: 1119 LVNEKSKLA-EIEEIKCRQEKEITKLN-------EELKSHKLESIKEITNLKDAKQLLIQ 1170
Query: 984 AQMEEKASLNRQLESELQMLKKECETLR-QNQGEGQHLQNSFKHPAGKTAASHQGKEAWG 1042
++E + + L++ ++ K+ + L+ Q + E + L+ F K + + KE
Sbjct: 1171 QKLELQGKAD-SLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGM 1229
Query: 1043 PGHKEATMELLRVKDRAIELERNNAALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSA 1102
H+E +L + L N ++ E Q + ++ LE Q +I L+
Sbjct: 1230 KKHEENEAKLTM---QITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQ 1286
Query: 1103 FLQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKE--TENESLQRQQEQL 1160
Q+ L + K + E L Q+ L Q L +E EN+SLQ + Q
Sbjct: 1287 NNQDERRALLERCLKGEGEIEKL--QTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQ- 1343
Query: 1161 TAAYEALLQDHEHLGTLHERQSAEYEALIRQHSC 1194
A +D+E + + +R+H C
Sbjct: 1344 -ALNRKWAEDNEVQNCM--ACGKGFSVTVRRHHC 1374
Score = 150 bits (380), Expect = 9e-36
Identities = 244/1130 (21%), Positives = 451/1130 (39%), Gaps = 144/1130 (12%)
Query: 331 ELTRCKEKLHDVDFYKARMEE----LREDNIILIETKAM-LEEQLTAARARGDKVH-ELE 384
EL + E +HD E L+ D++ L+ + L+ L + +++ ELE
Sbjct: 55 ELFKHYEAVHDAGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELE 114
Query: 385 KEN--LQLKSKLHDLELDRDTDKKRIEELLEENMVLEIAQKQSMN----ESAHLGWELEQ 438
K Q ++K L D + + +E+ LEE KQ + ++A L E+
Sbjct: 115 KYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIAD 174
Query: 439 LSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASLVLEESGLK-CG 497
+ D + L E A ++ +L +E + IQ L+ +L+ G++
Sbjct: 175 IKSKYDEERS--------LREAAEQKVTRLTEELNKEATVIQDLKTE--LLQRPGIEDVA 224
Query: 498 ELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSDMETLKADKARQIK 557
L+KE Q+ ++ + + ERE + +D + E S + + A +++
Sbjct: 225 VLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVA 284
Query: 558 DLEQEKDHLNRAMWSLRERSQVSSEARMK---------------DVEKEN--KALHQTVT 600
QE L ++ L +++Q +E +K V K+N LHQ
Sbjct: 285 VYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDL 344
Query: 601 EANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGRLARKVTSLETATEK 660
+ S+L + LHR + EKGE +KL+ EL ++ + L + L+ E
Sbjct: 345 DCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQRE- 403
Query: 661 VEALEHESQGLQLE---NRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVETMR 717
E E GLQL+ N+ K L+T + + + G ++ +QL +E L + + +
Sbjct: 404 ----EKEQHGLQLQSEINQLHSKLLETERQLG-EAHGRLKEQRQLSSEKLMDKE--QQVA 456
Query: 718 FTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLES 777
KL+++E + ++ EL+ +D K ++ + L+ QS +A+ Q LE
Sbjct: 457 DLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQ---QSTTAKLREAQNDLEQ 513
Query: 778 SSHKTQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLL 837
+ + ++ LEA L++ E + L + E +A E E A L +L
Sbjct: 514 VLRQIGDKDQKIQNLEA---LLQKSKENISLLEKEREDLYAKIQAGEGETAVL---NQLQ 567
Query: 838 EKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDNRDLT 897
EK Q +L + + + S + A E + ++ A R A ++ LE +L
Sbjct: 568 EKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELN 627
Query: 898 KQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSDTKY 957
Q+ ++ L D+ ++ LS+E K +Q + L L DT
Sbjct: 628 SQLNESKEKVSQL--DIQIKAKTELLLSAEAAKTAQ---RADLQNHL---------DTAQ 673
Query: 958 KILEGRNESALKTTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLKKECETLRQNQGEG 1017
L+ + + K T + + + A++++K QLES L+ K++ +L Q E
Sbjct: 674 NALQDKQQELNKITTQLDQ-----VTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEE- 727
Query: 1018 QHLQNSFKHPAGKTAASHQGKEAWGPGHKEATMELLRVKDRAIELERNNAALQAEKQLLK 1077
L+ K K A ++E+ K++A++ + L + +L
Sbjct: 728 --LEGQIK----KLEAD--------------SLEVKASKEQALQDLQQQRQLNTDLELRA 767
Query: 1078 EQL-QHLETQNVTFSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQSAALTAQY 1136
+L + LE + SS L LQK+S L+ L Q + Q+ + S Q+
Sbjct: 768 TELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQH 827
Query: 1137 TLLQNHHTAKETENESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYE--------AL 1188
L N TE + ++ ++E L + + + +E+E A+
Sbjct: 828 EELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAI 887
Query: 1189 IRQHSCLKTLHRNLELEH----KELGERHGDMLKRKAELEEREKVLTTEREALQQEQRTN 1244
+ K L L+++ KE E + K K + + L + +E L Q Q T
Sbjct: 888 LDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTL 947
Query: 1245 ALAMGENQRLRGELDRVNFLHHQLKGEYEELHAHTK-----------ELKTSLNNAQLEL 1293
E Q+L+G ++ + Q K + E L K +L+ L A EL
Sbjct: 948 KQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQEL 1007
Query: 1294 NRWQARFDELKEQHQTMDISLTKLDN-----HCELLSRLKGNLEEENHHLLSQIQLLSQQ 1348
+ + L+ ++ + +L + ELL+ + E L+Q L+S +
Sbjct: 1008 AAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNR 1067
Query: 1349 NQM---------------LLEQNMENKEQYHEEQKQYIDKLNALRRHKEK 1383
NQ+ LEQ+ KEQ +E+ + + + + KEK
Sbjct: 1068 NQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEK 1117
Score = 150 bits (379), Expect = 1e-35
Identities = 261/1206 (21%), Positives = 509/1206 (42%), Gaps = 216/1206 (17%)
Query: 183 EELEALSRSMVLHLRRLIDQRDECTELIVDLTQERDYLQAQHPPSPIKSSSADSTPSPTS 242
+EL+ L S+ L + TE ++ Q+ L+ +H + + +T
Sbjct: 288 QELQKLKSSV----NELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKD 343
Query: 243 ----------SLSSEDKQHLAVELADTKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQ 292
S S + VEL++ +++++EL + + + E QL + +
Sbjct: 344 LDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQRE 403
Query: 293 KVKQENIQLAADARSARAYRDELDSLREKANRVERLELELTRCKEKLHDVDFYKARMEEL 352
+ +Q +QL + E++ L K LE R + H R++E
Sbjct: 404 EKEQHGLQL----------QSEINQLHSKL-------LETERQLGEAH------GRLKEQ 440
Query: 353 REDNIILIETKAMLEEQLTAARARGDKVHELEKENLQLKSKL-HDLELDRDTDKKRIEEL 411
R+ L K M +EQ A D +L + QLK K+ + EL DK + +
Sbjct: 441 RQ----LSSEKLMDKEQQVA-----DLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQH- 490
Query: 412 LEENMVLEIAQKQSMNESAHLGWELEQLSKNADLSDASRKSFVFE-LNECASSRILKLEK 470
+E L+ + + E+ + +LEQ+ + + D +K E L + + I LEK
Sbjct: 491 -QEQQALQQSTTAKLREAQN---DLEQVLR--QIGDKDQKIQNLEALLQKSKENISLLEK 544
Query: 471 ENQSLQSTIQGLRDASLVLEESGLKCGELEKENHQLSKKI----EKLQTQLEREKQSNQD 526
E + L + IQ + VL +L+++NH L +++ EKL+ Q E KQ+ ++
Sbjct: 545 EREDLYAKIQAGEGETAVL-------NQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQEN 597
Query: 527 LETLSEELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMK 586
L ++++K HL A + R+
Sbjct: 598 LH----------------------------DQVQEQKAHLRAA------------QDRVL 617
Query: 587 DVEKENKALHQTVTEANGKLSQLEFE---KRQLHRDLEQAK--EKGERAEKLERELQRLQ 641
+E L+ + E+ K+SQL+ + K +L E AK ++ + L+ LQ
Sbjct: 618 SLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQ 677
Query: 642 EENGRLARKVTSLETATEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQ 701
++ L + T L+ T K++ + L+ + ++ +L+ + +LEG K+
Sbjct: 678 DKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEG---QIKK 734
Query: 702 LDAENLELRRLVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSY 761
L+A++LE++ A E+ Q L+++++ N DL + S++LE+
Sbjct: 735 LEADSLEVK-------------ASKEQALQDLQQQRQ---LNTDLELRATELSKQLEMEK 778
Query: 762 QSVSAENLRLQQSLESSSHKTQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRK 821
+ VS+ L LQ+ E+ ++++ +L + E E+Q L++D E L +++ E + +
Sbjct: 779 EIVSSTRLDLQKKSEA----LESIKQKLTKQEEEKQILKQDFETLS-QETKIQHEELNNR 833
Query: 822 ALEQEVAQLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRA-LDKELARCR 880
++ V +L+K K +EKEA EL + + D +K+S K S++ +KE + +
Sbjct: 834 -IQTTVTELQKVK--MEKEA----LMTEL--STVKDKLSKVSDSLKNSKSEFEKENQKGK 884
Query: 881 DAAGKLKELEKDNRDLTKQVTVH----ARTLTTLREDLVLEKLKSQQLSSELDKLSQELE 936
A + +LEK ++L Q+ V + L++ L EK S QL EL+ + ++L
Sbjct: 885 AA---ILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQL- 940
Query: 937 KVGLNRELLLQEDDSGSDTKYKILEGRNESALKTTLAMKEEKIVLLEAQME----EKASL 992
+ Q ++ + + L+G N + LK + K+++I L+ +++ +K L
Sbjct: 941 -------IQAQNTLKQNEKEEQQLQG-NINELKQSSEQKKKQIEALQGELKIAVLQKTEL 992
Query: 993 NRQLE-------SELQMLKKECETLRQNQGEGQ----HLQNSFKHPAGKTAASHQGKEAW 1041
+L+ EL K++ L+ N + Q LQ+ F + A+ Q ++
Sbjct: 993 ENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSV 1052
Query: 1042 GPGHKEATMELL--------------RVKDRAIELERNNAALQAEKQLLKEQLQHLETQN 1087
A +L+ +K LE+++A + + Q + LQ ++ +
Sbjct: 1053 EEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEK 1112
Query: 1088 VTFSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKE 1147
+++ + + A ++E + + KL N L S + T L++
Sbjct: 1113 SLKEKELVNEKSKLAEIEEIKCRQEKEITKL---NEELKSHKLESIKEITNLKDAKQLLI 1169
Query: 1148 TENESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHK 1207
+ LQ + + L AA E Q+ + L ++ E E L ++ K + E++ K
Sbjct: 1170 QQKLELQGKADSLKAAVE---QEKRNQQILKDQVKKEEEEL-KKEFIEKEAKLHSEIKEK 1225
Query: 1208 ELG--ERHGDMLKRKAELEEREKVLTTEREALQQEQRTNALAMGENQRLRGEL------- 1258
E+G + + K ++ + L T ++ Q QR + + LRGE+
Sbjct: 1226 EVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATV 1285
Query: 1259 -----DRVNFLHHQLKGEYEELHAHTKELKTSLNNAQLELNRWQARFDELKEQHQTMDIS 1313
+R L LKGE E ++L+T + Q +L+ A EL ++Q++ I
Sbjct: 1286 QNNQDERRALLERCLKGEGE-----IEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIK 1340
Query: 1314 LTKLDN 1319
T+ N
Sbjct: 1341 HTQALN 1346
Score = 88.2 bits (217), Expect = 7e-17
Identities = 131/618 (21%), Positives = 258/618 (41%), Gaps = 105/618 (16%)
Query: 800 RRDLEALRLANAQLEGAEKDRKALEQEVA-QLEKDKKLLEKEAKRLWQQVELKDAVLDDS 858
R D+ LR L+ + K+ K +E+ +LEK + L ++EAK D ++ DS
Sbjct: 82 RDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAK--------PDGLVTDS 133
Query: 859 TAKLSAVEKESRALDKELARCRDAAGKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEK 918
+A+L ++E++ L+E + +N ++ + + + L ++ K
Sbjct: 134 SAELQSLEQQ-----------------LEEAQTENFNIKQMKDLFEQKAAQLATEIADIK 176
Query: 919 LKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSDTKYKILEGRNESALKTTLAMKEEK 978
K + S + Q++ ++ E L +E D K ++L+ ++ +K+E
Sbjct: 177 SKYDEERSLREAAEQKVTRL---TEELNKEATVIQDLKTELLQ---RPGIEDVAVLKKE- 229
Query: 979 IVLLEAQ-MEEKASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTAASHQG 1037
L++ Q + + +L R+ ESE LK EC+ L+ + T + +
Sbjct: 230 --LVQVQTLMDNMTLERERESE--KLKDECKKLQSQYASSE-----------ATISQLRS 274
Query: 1038 KEAWGPGHKEATMELLRVKDRAIELERNNAALQAEKQLLKEQLQHLETQNVTFSSQILTL 1097
+ A GP + A E Q LK + L +N T + +L
Sbjct: 275 ELAKGP--------------------QEVAVYVQELQKLKSSVNELTQKNQTLTENLLKK 314
Query: 1098 QKQSAFLQE-HN---TTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETENESL 1153
++ L+E HN + + A L ++ + L+A T L H + E+
Sbjct: 315 EQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEAT 374
Query: 1154 QRQQEQLTAA---YEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKELG 1210
Q+ +E+L+ Y+ L + + L +R+ E L Q S + LH L ++LG
Sbjct: 375 QKLKEELSEVETKYQHLKAEFKQLQ--QQREEKEQHGLQLQ-SEINQLHSKLLETERQLG 431
Query: 1211 ERHGDMLKRKAELEEREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQL-- 1268
E HG LK + +L EK++ E++ + + + L ++L+ ++ L HQL
Sbjct: 432 EAHG-RLKEQRQLSS-EKLMDKEQQVADLQLKLSRL----EEQLKEKVTNSTELQHQLDK 485
Query: 1269 -KGEYEELHAHTKELKTSLNNAQLELNRWQARFDELKEQHQTMDISLTKLDNHCELLSRL 1327
K +++E A + L AQ +L + + + ++ Q ++ L K + LL +
Sbjct: 486 TKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKE 545
Query: 1328 K-----------------GNLEEENHHLLSQIQLLSQQNQMLLEQNMENKEQYHEEQKQY 1370
+ L+E+NH L Q+ L+++ + E + + +E H++ ++
Sbjct: 546 REDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQ 605
Query: 1371 IDKLNALRRHKEKLEEKI 1388
L A + LE +
Sbjct: 606 KAHLRAAQDRVLSLETSV 623
Score = 55.5 bits (132), Expect = 5e-07
Identities = 81/471 (17%), Positives = 191/471 (40%), Gaps = 24/471 (5%)
Query: 1007 CETLRQNQGEGQHLQNSFK--HPAGKTAASHQGKEAWGPGHKEATMELLRVKDRAIELER 1064
C ++ G L ++ H AG + H G+ + T+ V+D L+
Sbjct: 43 CPQCMKSLGSADELFKHYEAVHDAGNDSG-HGGESNLALKRDDVTLLRQEVQDLQASLKE 101
Query: 1065 NNAALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENST 1124
+ K+ L E+ Q L+ Q + + L++ QT+ ++
Sbjct: 102 EKWYSEELKKEL-EKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDL 160
Query: 1125 LSSQSAALTAQYTLLQNHHTAKETENESLQRQQEQLTAAYEALLQDHEHLGT-LHERQSA 1183
++A L + +++ + + + E+ +++ +LT + L T L +R
Sbjct: 161 FEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGI 220
Query: 1184 EYEALIRQHSC-LKTLHRNLELEHKELGERHGDMLKR-KAELEEREKVLTTEREALQQEQ 1241
E A++++ ++TL N+ LE + E+ D K+ +++ E ++ R L +
Sbjct: 221 EDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGP 280
Query: 1242 RTNALAMGENQRLRGELDRV---------NFL-----HHQLKGEYEELHAHTKELKTSLN 1287
+ A+ + E Q+L+ ++ + N L + +L+ ++ E K ++ +L+
Sbjct: 281 QEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLH 340
Query: 1288 NAQLELNRWQARFDELKEQHQTMDISLTKLDNHCELLSRLKGNLEEENHHLLSQIQLLSQ 1347
L+ + Q+R + + + L++ + L +E + HL ++ + L Q
Sbjct: 341 QKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQ 400
Query: 1348 QNQMLLEQNMENKEQYHEEQKQYIDKLNAL-RRHKEKLEEKIMDQYKFYDPPPKKKNHWI 1406
Q + + ++ + + ++ + ++ L H E++ + K D + + +
Sbjct: 401 QREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQL 460
Query: 1407 GAKALVKLIKPKKEGSRERLKSTVDSPPWQLESSDPASPAASQPLRSQAEN 1457
L + +K K S E L+ +D Q + + + LR +A+N
Sbjct: 461 KLSRLEEQLKEKVTNSTE-LQHQLDKTKQQHQEQQALQQSTTAKLR-EAQN 509
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 166 bits (421), Expect = 2e-40
Identities = 257/1131 (22%), Positives = 475/1131 (41%), Gaps = 138/1131 (12%)
Query: 280 TRHEVDQLVLELQKVKQENIQLAADARSARAYRDELDSLREKANRVERLELELTRCKEKL 339
+R E + + E + VK QLAA+ R + + EK E+L+ E C E
Sbjct: 841 SRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAE 900
Query: 340 HDVDFYKARMEELREDNIILIETKAMLEEQ------LTAARAR-GDKVHELEKENLQLKS 392
A+ +EL E I + +A +EE+ L A + + + ELE++ + +S
Sbjct: 901 ELRARLTAKKQELEE---ICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEES 957
Query: 393 KLHDLELDRDTDKKRIEELLEENMVLEIAQKQSMNESAHLGWELEQLSKNADLSDASRKS 452
L+L++ T + ++++L EE ++LE + E L + + + N + KS
Sbjct: 958 ARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKS 1017
Query: 453 FVFELNECAS------SRILKLEKENQSLQSTIQGLRDASLVLEESGLKC-GELEKENHQ 505
N+ + R+ + EK+ Q L+ T + L S L + + ++ + Q
Sbjct: 1018 LAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQ 1077
Query: 506 LSKKIEKLQTQL----EREKQSNQDLETLSEELIREKEQLQSDMETLKADK---ARQIKD 558
L+KK E+LQ L E Q N L+ + EL + +LQ D+E+ +A + +Q +D
Sbjct: 1078 LAKKEEELQAALARVEEEAAQKNMALKKI-RELESQISELQEDLESERASRNKAEKQKRD 1136
Query: 559 LEQEKDHLNRAMWSLRERSQVSSEARMKDVEKEN---KALHQTVTEANGKLSQLEFEKRQ 615
L +E + L + + + E R K ++ N K L + ++ ++ + Q
Sbjct: 1137 LGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQ 1196
Query: 616 LHRDLEQAKEKGERAE-KLERELQRLQEENGRLARKVTSL-------ETATEKVEALEHE 667
+L + E+ +R + LE+ Q L+ E G LA +V L E +KVEA E
Sbjct: 1197 AVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQE 1256
Query: 668 SQGLQLENRTLRKSL-DTLQNVSLQLEGLERDNKQLDAENLELRR--------LVETMRF 718
Q E +R L D + + ++L+ + Q D+++ +L + L +T
Sbjct: 1257 LQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQEL 1316
Query: 719 ----------TSTKLAQMERE----NQQLEREKE---ELRKNVDLLKA----LGKKSERL 757
STKL Q+E E +QLE E+E L K + L A + KK E
Sbjct: 1317 LQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDS 1376
Query: 758 ELSYQSVSAENLRLQQSLESSSHKTQTLESELGELEAERQALRRDLEALRL-ANAQLEGA 816
++ +LQ+ LE S + + + +LE + L+++L+ L + + Q + A
Sbjct: 1377 VGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSA 1436
Query: 817 ---EKDRKALEQEVAQ---------LEKDK---KLLEKEAKRLWQQVELKDAVLDDSTAK 861
EK +K +Q +A+ E+D+ + EKE K L L++A+ + A+
Sbjct: 1437 CNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAM--EQKAE 1494
Query: 862 LSAVEKESRALDKELARCRDAAGK-LKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLK 920
L + K+ R ++L +D GK + ELEK R L +QV L L ++L +
Sbjct: 1495 LERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDA 1554
Query: 921 SQQLSSELDKLSQELEKVGLNRELLLQEDDSGSDTKYKILEGRNESALKTTLAMKEEKIV 980
+L L + + E R+L +++ S K + + R A +++E+
Sbjct: 1555 KLRLEVNLQAMKAQFE-----RDLQGRDEQSEEKKKQLVRQVREMEA-----ELEDER-- 1602
Query: 981 LLEAQMEEKASLNRQLESELQMLKKECETLRQNQGEG----QHLQNSFK---HPAGKTAA 1033
Q + ++LE +L+ L+ ++ +N+ E + LQ K T A
Sbjct: 1603 ---KQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRA 1659
Query: 1034 SHQGKEAWGPGH----KEATMELLRVKDRAIELERNNAALQAEKQLLKEQLQHLETQNVT 1089
S + A + K E++++++ ER Q E+ L +++ + +
Sbjct: 1660 SREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGAL 1719
Query: 1090 FSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETE 1149
+ L+ + A L+E Q T + + Q + L ++H E
Sbjct: 1720 ALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENA 1779
Query: 1150 NESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKEL 1209
+ L+RQ ++L + LQ+ E GT+ + A AL + + L L+ E KE
Sbjct: 1780 RQQLERQNKEL----KVKLQEME--GTVKSKYKASITAL---EAKIAQLEEQLDNETKE- 1829
Query: 1210 GERHGDMLKRKAELEEREKVLTTEREALQQ--EQRTNALAMGENQRLRGELDRVNFLHHQ 1267
R+A ++ + ++ L Q ++R NA ++ + + D+ + Q
Sbjct: 1830 ---------RQAACKQVRRTEKKLKDVLLQVDDERRNA------EQYKDQADKASTRLKQ 1874
Query: 1268 LKGEYEELHAHTKELKTSLNNAQLELNRWQARFDELKEQHQTMDISLTKLD 1318
LK + EE + S Q EL D + + ++ L + D
Sbjct: 1875 LKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRRGD 1925
Score = 159 bits (403), Expect = 2e-38
Identities = 246/1149 (21%), Positives = 471/1149 (40%), Gaps = 113/1149 (9%)
Query: 286 QLVLELQKVKQENIQLAADARSARAYR--DELDSLREKANRVERL---ELELTRCKEKLH 340
Q L KV Q N R+ + +R ++ L + + + E + E EL + +EK
Sbjct: 803 QQQLTAMKVLQRNCAAYLKLRNWQWWRLFTKVKPLLQVSRQEEEMMAKEEELVKVREKQL 862
Query: 341 DVDFYKARMEELREDNIILIETKAMLEEQLTAARARGDKVHELEKENLQLKSKL----HD 396
+ ME L+ L+ K L+EQL A + EL K +L HD
Sbjct: 863 AAENRLTEMETLQSQ---LMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHD 919
Query: 397 LELDRDTDKKRIEELLEENM-----VLEIAQKQSMNESAHLGWELEQLSKNADLSDASRK 451
LE + +++R + L E + E+ ++ ESA +LE+++ A L +
Sbjct: 920 LEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEE 979
Query: 452 SFVFELNECASSRILKLEKENQSLQSTIQGLRDASLVLEESGLKCGELEKENHQLSKKIE 511
+ E C KL KE + L+ I + + L E K L K ++ I
Sbjct: 980 QIILEDQNC------KLAKEKKLLEDRIA---EFTTNLTEEEEKSKSLAKLKNKHEAMIT 1030
Query: 512 KLQTQLEREKQSNQDLETLSEELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMW 571
L+ +L RE++ Q+LE +L + L + L+A A L ++++ L A+
Sbjct: 1031 DLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALA 1090
Query: 572 SLRERSQVSSEA--RMKDVEKENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGER 629
+ E + + A +++++E + L + + ++ E +KR L +LE K + E
Sbjct: 1091 RVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELED 1150
Query: 630 ---AEKLERELQRLQEENGRLARKVTSLETATEKVEALEHESQGLQLENRTLRKSLDTLQ 686
+ ++EL+ +E+ + +K E T + + E + Q L + L+ +
Sbjct: 1151 TLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEE-LAEQLEQTK 1209
Query: 687 NVSLQLEGLER--DNKQLDAENLELRRLVETMRFTSTKLAQMERENQQLE---REKEELR 741
V LE ++ +N++ + N E++ L++ + K ++E + Q+L+ E E +R
Sbjct: 1210 RVKANLEKAKQTLENERGELAN-EVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVR 1268
Query: 742 KNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSSHKTQTLESELGELEAERQALRR 801
L K +L++ +V+ L QS SS T+ + +L+ ++ L+
Sbjct: 1269 TE------LADKVTKLQVELDNVTG---LLSQSDSKSSKLTKDFSALESQLQDTQELLQE 1319
Query: 802 DLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAK 861
+ + +L+ E ++ + +++ + E+ K LEK+ L QV ++DS
Sbjct: 1320 ENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGC 1379
Query: 862 LSAVEKESRALDKEL----ARCRDAAGKLKELEKDNRDLTKQVTVHARTLTTLREDLVLE 917
L E+ R L K+L R + +LEK L +++ +DL+++
Sbjct: 1380 LETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQEL-----------DDLLVD 1428
Query: 918 KLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSDTKYKILEGRNESALKTTLAMKEE 977
+Q + L+K ++ ++ LL E+ + S KY R E+ +
Sbjct: 1429 LDHQRQSACNLEKKQKKFDQ-------LLAEEKTIS-AKYAEERDRAEAEAREKETKALS 1480
Query: 978 KIVLLEAQMEEKASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTAASHQG 1037
LE ME+KA L R L + + ++ + + + G+ H K A Q
Sbjct: 1481 LARALEEAMEQKAELER-LNKQFRTEMEDLMSSKDDVGKSVHELEKSKR------ALEQQ 1533
Query: 1038 KEAWGPGHKEATMELLRVKDRAIELERNNAALQAEKQLLKEQLQHLETQNVTFSSQIL-T 1096
E +E EL +D + LE N LQA K + LQ + Q+ Q++
Sbjct: 1534 VEEMKTQLEELEDELQATEDAKLRLEVN---LQAMKAQFERDLQGRDEQSEEKKKQLVRQ 1590
Query: 1097 LQKQSAFLQEHNTTLQTQTA---KLQVENSTLSSQSAALTAQYTLLQNHHTAKETENESL 1153
+++ A L++ A KL+++ L + + + + +
Sbjct: 1591 VREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDC 1650
Query: 1154 QRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGERH 1213
R+ + A+ E +L + + AE L + + + R + E EL +
Sbjct: 1651 MRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEI 1710
Query: 1214 GDMLKRKA-ELEEREKV---LTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQLK 1269
+ + A LEE+ ++ + E L++EQ L ++ ++D++N
Sbjct: 1711 ANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQIN-----TD 1765
Query: 1270 GEYEELHAHTKELKTSLNNAQLELNRWQARFDELKEQHQTMD--------ISLTKLDNHC 1321
E HA E NA+ +L R + ELK + Q M+ S+T L+
Sbjct: 1766 LNLERSHAQKNE------NARQQLER---QNKELKVKLQEMEGTVKSKYKASITALEAKI 1816
Query: 1322 ELLSRLKGNLEEENHHLLSQIQLLSQQNQMLL---EQNMENKEQYHEEQKQYIDKLNALR 1378
L N +E Q++ ++ + +L + N EQY ++ + +L L+
Sbjct: 1817 AQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLK 1876
Query: 1379 RHKEKLEEK 1387
R E+ EE+
Sbjct: 1877 RQLEEAEEE 1885
Score = 144 bits (363), Expect = 9e-34
Identities = 245/1130 (21%), Positives = 486/1130 (43%), Gaps = 128/1130 (11%)
Query: 184 ELEALSRSMVLHLRRLIDQRDECTELIVDLTQERDYLQAQHPPSPIKSSSADSTPSPTSS 243
E+E L ++ +L +Q TEL + + R L A+ K + +
Sbjct: 870 EMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAK------KQELEEICHDLEAR 923
Query: 244 LSSEDK--QHLAVELADTKARLRRVRQELEDKTEQLVDTRH--EVDQLVLE--LQKVKQE 297
+ E++ QHL E K ++++ QELE++ E+ R +++++ E L+K+++E
Sbjct: 924 VEEEEERCQHLQAE----KKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEE 979
Query: 298 NIQLAAD----ARSARAYRDELDSLREKANRVERLELELTRCKEK----LHDVDFYKARM 349
I L A+ + D + E L + K K + D++ R
Sbjct: 980 QIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRRE 1039
Query: 350 EELREDNIILIETKAMLEEQLTAARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRI- 408
E+ R++ L +T+ LE T D++ EL+ + +LK +L E + R+
Sbjct: 1040 EKQRQE---LEKTRRKLEGDSTDL---SDQIAELQAQIAELKMQLAKKEEELQAALARVE 1093
Query: 409 EELLEENMVL-EIAQKQSMNESAHLGWELEQLSKN------ADLS---DASRKSFVFELN 458
EE ++NM L +I + +S E E+ S+N DL +A + L+
Sbjct: 1094 EEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLD 1153
Query: 459 ECASSRIL--KLEKENQSLQSTIQGLRDASLVLEESGLKCGELEKENHQLSKKIEKLQTQ 516
A+ + L K E+E L+ T++ EE+ ++++ + S+ +E+L Q
Sbjct: 1154 STAAQQELRSKREQEVNILKKTLE---------EEAKTHEAQIQEMRQKHSQAVEELAEQ 1204
Query: 517 LEREKQSNQDLETLSEELIREKEQLQSDMETL---KADKARQIKDLEQEKDHLN-RAMWS 572
LE+ K+ +LE + L E+ +L ++++ L K D + K +E + L +
Sbjct: 1205 LEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEG 1264
Query: 573 LRERSQVSSEARMKDVEKENKA--LHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERA 630
R R++++ + VE +N L Q+ ++++ + QL E +E+ +
Sbjct: 1265 ERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQK 1324
Query: 631 EKLERELQRLQEENGRLARKVTSLETATEKVEALEHESQGLQLENRTLRK----SLDTLQ 686
L +L+++++E + LE E LE + L + ++K S+ L+
Sbjct: 1325 LSLSTKLKQVEDEKNSFREQ---LEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLE 1381
Query: 687 NVSLQLEGLERDNKQLDAENLELRRLVETMRFTSTKLAQMERENQQLEREKEELRKNVDL 746
L++D + L + E + + T T+L Q E L + + R++
Sbjct: 1382 TAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQ---ELDDLLVDLDHQRQSACN 1438
Query: 747 LKALGKKSERLELSYQSVSAENLRLQQSLESSSHKTQTLESELGELEAERQALRRDLEAL 806
L+ KK ++L +++SA+ + E+ + + +T L E + +LE L
Sbjct: 1439 LEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERL 1498
Query: 807 -RLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQQV-ELKDAVLDDSTAKLSA 864
+ ++E + + + V +LEK K+ LE++ + + Q+ EL+D + AKL
Sbjct: 1499 NKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKL-R 1557
Query: 865 VEKESRALDKELARCRDAAGKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQL 924
+E +A+ + RD G+ ++ E+ + L +QV L R+ + ++L
Sbjct: 1558 LEVNLQAMKAQFE--RDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKL 1615
Query: 925 SSELDKLSQELEKVGLNRELLLQEDDSGSDTKYKILEGRNESALK---TTLAMKEEKIVL 981
+L L ++ NR+ +++ + L+ + + ++ T A +EE
Sbjct: 1616 EMDLKDLEAHIDSANKNRDEAIKQ--------LRKLQAQMKDCMRELDDTRASREE---- 1663
Query: 982 LEAQMEEKASLNRQLESELQMLKKEC----ETLRQNQGEGQHLQNSFKHPAGKTAASHQG 1037
+ AQ +E + +E+E+ L++E RQ Q E L + + +GK A + +
Sbjct: 1664 ILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEE 1723
Query: 1038 KEAWGPGHKEATMELLRVKDRAIELERNNAALQAEKQLLKEQLQHLETQNVTFSSQILTL 1097
K R++ R +LE Q +L+ ++L+ Q ++ L L
Sbjct: 1724 KR--------------RLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTD-LNL 1768
Query: 1098 QKQSAFLQEH-NTTLQTQTAKLQV-----ENSTLSSQSAALTAQYTLLQNHHTAKETENE 1151
++ A E+ L+ Q +L+V E + S A++TA + ++ +NE
Sbjct: 1769 ERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIA--QLEEQLDNE 1826
Query: 1152 SLQRQQE-QLTAAYEALLQDHEHLGTLHERQSAEY--EALIRQHSCLKTLHRNLELEHKE 1208
+ +RQ + E L+D L ER++AE + + + LK L R LE +E
Sbjct: 1827 TKERQAACKQVRRTEKKLKD-VLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEE 1885
Query: 1209 LGERHGDMLKRKAELEEREKVLTTEREALQQEQRTNALAMGENQRLRGEL 1258
+ K + ELE+ T +A+ +E ++ +N+ RG+L
Sbjct: 1886 AQRANASRRKLQRELED----ATETADAMNRE-----VSSLKNKLRRGDL 1926
Score = 129 bits (324), Expect = 3e-29
Identities = 192/908 (21%), Positives = 392/908 (43%), Gaps = 101/908 (11%)
Query: 118 EEIKKVLLLVLGCAVQCERKEEFIERIKQLDIETQAGIVAHIQEVTHNQENVFDLQWLEL 177
++I ++ + +Q +KEE E QA + +E Q+N+ + EL
Sbjct: 1062 DQIAELQAQIAELKMQLAKKEE----------ELQAALARVEEEAA--QKNMALKKIREL 1109
Query: 178 PDVAPEELEALSRSMVLHLRRLIDQRDECTELIVDLTQERDYLQAQHPPSPIKSSSADST 237
E E L + +RD EL T+ D L + ++S
Sbjct: 1110 ESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEV 1169
Query: 238 PSPTSSLSSEDKQHLAVELADTKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQKVKQ- 296
+L E K H +A+++ +RQ+ E+L + + ++ L+K KQ
Sbjct: 1170 NILKKTLEEEAKTH--------EAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQT 1221
Query: 297 ---ENIQLAADAR-----------SARAYRDELDSLREKANRVERLELELTRCKEKLH-D 341
E +LA + + + +L L+ K N ER+ EL KL +
Sbjct: 1222 LENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVE 1281
Query: 342 VDFYKARMEELREDNIILIETKAMLEEQLTAARARGDKVHELEKENLQLKSKLHDLELDR 401
+D + + + L + + LE QL + + + E ++ L L +KL +E ++
Sbjct: 1282 LDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQ---ELLQEENRQKLSLSTKLKQVEDEK 1338
Query: 402 DTDKKRIEELLE--ENMVLEIA--------QKQSMNESAHLGWELEQLSK--NADLSDAS 449
++ ++++EE E N+ +IA K+ M +S E++ + DL S
Sbjct: 1339 NSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLS 1398
Query: 450 RKSFVFELNECASSRILKLEKENQSLQSTIQGL-------RDASLVLEESGLKCGELEKE 502
++ +E + KLEK LQ + L R ++ LE+ K +L E
Sbjct: 1399 QR------HEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAE 1452
Query: 503 NHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSDMETLKADKARQIKDLEQE 562
+S K + + + E E + + + E + ++++E L +++DL
Sbjct: 1453 EKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSS 1512
Query: 563 KDHLNRAMWSLRERSQVSSEARMKDVEKENKALH---QTVTEANGKLS-QLEFEKRQLHR 618
KD + +++ L E+S+ + E ++++++ + + L Q +A +L L+ K Q R
Sbjct: 1513 KDDVGKSVHEL-EKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFER 1571
Query: 619 DL----EQAKEKGERAEKLERELQ-RLQEENGRLARKVTS---LETATEKVEA-LEHESQ 669
DL EQ++EK ++ + RE++ L++E + + V + LE + +EA ++ ++
Sbjct: 1572 DLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANK 1631
Query: 670 GLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVETMRF----TSTKLAQ 725
+ LRK +++ +L+ +++ A+ E + +++M +LA
Sbjct: 1632 NRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAA 1691
Query: 726 MERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSSHKTQTL 785
ER +Q ++E++EL ++ + GK + LE + + A +L++ LE T+ +
Sbjct: 1692 AERAKRQAQQERDELAD--EIANSSGKGALALE-EKRRLEARIAQLEEELEEEQGNTELI 1748
Query: 786 ESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLW 845
L + + + DL N + A+K+ A + QLE+ K L+ + + +
Sbjct: 1749 NDRLKKANLQIDQINTDL------NLERSHAQKNENARQ----QLERQNKELKVKLQEME 1798
Query: 846 QQVELK-DAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDNRDLTKQVTVHA 904
V+ K A + AK++ +E++ LD E + A +++ EK +D+ QV
Sbjct: 1799 GTVKSKYKASITALEAKIAQLEEQ---LDNETKERQAACKQVRRTEKKLKDVLLQVDDER 1855
Query: 905 RTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSDTKYKILEGRN 964
R ++ + +QL +L++ +E ++ +R L +E + ++T + R
Sbjct: 1856 RNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAM--NRE 1913
Query: 965 ESALKTTL 972
S+LK L
Sbjct: 1914 VSSLKNKL 1921
Score = 114 bits (285), Expect = 1e-24
Identities = 172/752 (22%), Positives = 317/752 (42%), Gaps = 105/752 (13%)
Query: 704 AENLELRRLVETMRFTSTK-LAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQ 762
A L+LR FT K L Q+ R+ +++ ++EEL K + A + +E
Sbjct: 817 AAYLKLRNWQWWRLFTKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQS 876
Query: 763 SVSAENLRLQQSLESSSHKTQTLESELGELEAERQALRR---DLEA-LRLANAQLEGAEK 818
+ AE L+LQ+ L++ + E L A++Q L DLEA + + + +
Sbjct: 877 QLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQA 936
Query: 819 DRKALEQEVAQLE---------KDKKLLEK---EAKRLWQQVELKDAVLDDSTAKLSAVE 866
++K ++Q + +LE + K LEK EAK +++E + +L+D KL+
Sbjct: 937 EKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKL--KKLEEEQIILEDQNCKLA--- 991
Query: 867 KESRALDKELARCRDAAGKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSS 926
KE + L+ +A + L E E+ ++ L K H +T L E L E
Sbjct: 992 KEKKLLEDRIA---EFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRRE--------- 1039
Query: 927 ELDKLSQELEKVGLNRELLLQEDDSGSDTKYKILEGRNESA-LKTTLAMKEEKIVLLEAQ 985
+K QELEK R+L E DS +D +I E + + A LK LA KEE++ A+
Sbjct: 1040 --EKQRQELEKT--RRKL---EGDS-TDLSDQIAELQAQIAELKMQLAKKEEELQAALAR 1091
Query: 986 MEEKASLN-------RQLESELQMLKKECETLR--QNQGEGQH---------LQNSFKHP 1027
+EE+A+ R+LES++ L+++ E+ R +N+ E Q L+ +
Sbjct: 1092 VEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDT 1151
Query: 1028 AGKTAASHQGK--------------EAWGPGHKEATMELLRVKDRAIE-LERNNAALQAE 1072
TAA + + E H+ E+ + +A+E L +
Sbjct: 1152 LDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRV 1211
Query: 1073 KQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQSAAL 1132
K L++ Q LE + ++++ L + + ++ Q +LQV+ + L
Sbjct: 1212 KANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTEL 1271
Query: 1133 TAQYTLLQ---NHHTAKETENESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALI 1189
+ T LQ ++ T ++++S + + +A E+ LQD + L RQ +
Sbjct: 1272 ADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKL 1331
Query: 1190 RQ-----HSCLKTLHRNLELEH---KELGERHGDMLKRKAELEEREKVLTTEREALQQEQ 1241
+Q +S + L E +H K++ H + K ++E+ L T E ++ Q
Sbjct: 1332 KQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQ 1391
Query: 1242 RTNALAMGENQRLRGELDRVNFLHHQLKGEYEELHAHTKELKTSLNNAQLELNRWQARFD 1301
+ ++ D++ +L+ E ++L + S N L + Q +FD
Sbjct: 1392 KDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACN----LEKKQKKFD 1447
Query: 1302 ELKEQHQTMDISLTKLDNHCELLSRLKGNLEEENHHLLSQIQLLSQQNQMLLEQNMENKE 1361
+L + +T+ + E R + E+ LS + L E+ ME K
Sbjct: 1448 QLLAEEKTISAK------YAEERDRAEAEAREKETKALSLARAL--------EEAMEQKA 1493
Query: 1362 QYHEEQKQYIDKLNALRRHKEKLEEKIMDQYK 1393
+ KQ+ ++ L K+ + + + + K
Sbjct: 1494 ELERLNKQFRTEMEDLMSSKDDVGKSVHELEK 1525
Score = 82.8 bits (203), Expect = 3e-15
Identities = 135/611 (22%), Positives = 250/611 (40%), Gaps = 71/611 (11%)
Query: 820 RKALEQEVAQLEKDKKLLEKEAKRL----WQQVELKDAVLDDSTAKLSAVEKESRALDKE 875
RKA + QL K L A L WQ L V ++S E+E A ++E
Sbjct: 796 RKAFAKRQQQLTAMKVLQRNCAAYLKLRNWQWWRLFTKV--KPLLQVSRQEEEMMAKEEE 853
Query: 876 LARCRDAAGKLKELEKDNRDLTKQVTVHARTLTT---LREDLVLEK---LKSQQLSSELD 929
L + R+ K+L +NR LT+ T+ ++ + L+E L E ++++L + L
Sbjct: 854 LVKVRE-----KQLAAENR-LTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLT 907
Query: 930 KLSQELEKVGLNRELLLQEDDSGSDTKYKILEGRNESALKTTLAMKEEKIVLLEAQMEEK 989
QELE++ + E ++E++ L+ ++ I LE Q+EE+
Sbjct: 908 AKKQELEEICHDLEARVEEEEERCQH------------LQAEKKKMQQNIQELEEQLEEE 955
Query: 990 ASLNRQLESELQMLKKECETLRQNQG--EGQHLQNSFKHPAGKTAASHQGKEAWGPGHKE 1047
S ++L+ E + + + L + Q E Q+ + + + + + K
Sbjct: 956 ESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKS 1015
Query: 1048 ATMELLRVKDRAI--ELERNNAALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFL- 1104
++ L+ K A+ +LE + ++Q L++ + LE + S QI LQ Q A L
Sbjct: 1016 KSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELK 1075
Query: 1105 -QEHNTTLQTQTAKLQVENSTLSSQSAA-----LTAQYTLLQNHHTAKETENESLQRQQE 1158
Q + Q A +VE A L +Q + LQ ++ ++Q+
Sbjct: 1076 MQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKR 1135
Query: 1159 QLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHK-------ELGE 1211
L EAL + E TL + +A+ E ++ + L + LE E K E+ +
Sbjct: 1136 DLGEELEALKTELED--TL-DSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQ 1192
Query: 1212 RHGDMLKR-----------KAELEEREKVLTTEREALQQEQRTNALAMGENQRLRGELDR 1260
+H ++ KA LE+ ++ L ER L E + G+++ R +
Sbjct: 1193 KHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKR---KK 1249
Query: 1261 VNFLHHQLKGEYEELHAHTKELKTSLNNAQLELNRWQARFDELKEQHQTMDISLTKLDNH 1320
V +L+ ++ E EL + Q+EL+ + + + + L++
Sbjct: 1250 VEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQ 1309
Query: 1321 CELLSRLKGNLEEENHHLLS---QIQLLSQQNQMLLEQNMENKEQYHEEQKQYIDKLNAL 1377
+ L L+EEN LS +++ + + EQ E +E H +KQ +
Sbjct: 1310 LQDTQEL---LQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQV 1366
Query: 1378 RRHKEKLEEKI 1388
K+K+E+ +
Sbjct: 1367 ADMKKKMEDSV 1377
>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
Length = 1979
Score = 166 bits (420), Expect = 2e-40
Identities = 305/1393 (21%), Positives = 550/1393 (39%), Gaps = 198/1393 (14%)
Query: 159 IQEVTHNQENVFDLQWLELPDVAPEELEALSRSMVLHLRRLIDQRDECTELIVDLTQ--- 215
I+E+ N+ D E+ + + L+ H L D + EL L Q
Sbjct: 218 IKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGS 277
Query: 216 ---ERDYLQAQHPPSPIKSSSADSTPSPTSSLSSEDK-QHLAVELADTKAR---LRRVRQ 268
E D + I+ + S EDK + + +L+ + LRR ++
Sbjct: 278 GVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQE 337
Query: 269 ELEDKTEQLVDTRHEVDQLVLELQKVKQENIQ-----------LAADARSARAYRDELDS 317
+L + Q+++ E + L LE K++ ++ LA A +R + +
Sbjct: 338 QLNVEKRQIME---ECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQ-QA 393
Query: 318 LREKANRVERLELELTRCKEKLHDVDFYKARMEELREDNIILIETKAMLEEQLTAARARG 377
L + N + RL L + D K R+E L ++ +L + K L+ L
Sbjct: 394 LSDAENEIMRLS-SLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEY 452
Query: 378 DKVHELEKENLQLKSKLHDLELDRDTDKKRIEELL--EENMVLEIAQKQSMNESA--HLG 433
+ + ++ L S+LHDL L+ + ++ + + + +E ++ EI + N+ A H+
Sbjct: 453 EVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMI 512
Query: 434 WELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASLVLEESG 493
+QLSK + D+ +LN+ R+ +LE + + + ++ L +S
Sbjct: 513 LIKDQLSKQQNEGDSIISKLKQDLND-EKKRVHQLEDDKMDITKELDVQKEK---LIQSE 568
Query: 494 LKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEEL---IREKEQLQSD-----M 545
+ +L +L K+E L QL + ++SN ++ + EL IR+ E+ S M
Sbjct: 569 VALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELM 628
Query: 546 ETLKADKARQIKD--LEQEKDHLNRAMWSLRERSQVSSEARMK--DVEKENKALHQTVTE 601
++L D KD L++ + + +L E Q++ + DV+ EN+ L +
Sbjct: 629 QSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACED 688
Query: 602 ANGKL-------SQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGRLARKVTSL 654
+L +QL EK + L+ EKGE +L +RL EE + + + L
Sbjct: 689 VRHQLEECLAGNNQLSLEKNTIVETLKM--EKGEIEAELCWAKKRLLEEANKYEKTIEEL 746
Query: 655 ETATE---KVEALEHE-----SQGLQLENRTLRKSLDTLQN--------VSLQLEGL--- 695
A LEHE +Q +E L+K+++ + +S LE
Sbjct: 747 SNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQL 806
Query: 696 ---------------ERDNK---QLDAENLELRR---LVETMRFTSTKLAQMERENQQLE 734
ER +K +LD + LR+ L +T+ L M+ EN L+
Sbjct: 807 TQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQ 866
Query: 735 REKEELR------------KNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSSHKT 782
E E LR K +D + L + +L + + E Q+ +E +
Sbjct: 867 EELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSK 926
Query: 783 QTLESELGELEAERQALRRDLEALRLANAQLEGAEKD------RKALEQEVAQLEKDKKL 836
L L E + E R E + + QL EKD +K +EQ QL ++++
Sbjct: 927 MQLLQSLQEQKKEMDEFRYQHEQMNATHTQLF-LEKDEEIKSLQKTIEQIKTQLHEERQD 985
Query: 837 LEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDNRDL 896
++ + ++Q+ +++ +++ + K + E+ L K + ++ ++K L + N L
Sbjct: 986 IQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGI---KERELEIKLLNEKNISL 1042
Query: 897 TKQVTVHARTLTTLREDLVLEK-LKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSDT 955
TKQ+ ++ ++ +K L+ Q L + + S + V L ++L Q +
Sbjct: 1043 TKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQL--QAYAMEREK 1100
Query: 956 KYKIL--EGRNESALKTT-------LAMKEEKIVLLEAQMEEKASLNRQLESELQMLKKE 1006
+ +L + R S LKT +A KE ++ L+ +E L+ + ES Q + +E
Sbjct: 1101 VFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQ---DENKKLSTRFESSGQDMFRE 1157
Query: 1007 C-----ETLRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEATMELLRVKDRAIE 1061
+R+ E L + S G EA G + ELL+ +D+
Sbjct: 1158 TIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFE-ELLQERDK--- 1213
Query: 1062 LERNNAALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEHNTTLQTQTAKLQVE 1121
LK+Q++ +E + + +Q +SA LQE LQ Q
Sbjct: 1214 --------------LKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDN 1259
Query: 1122 NSTLSSQSAALTAQYTLLQNHHTAKETENESLQRQQE--QLTAAYEALLQDHEHLGTLHE 1179
NS L L Y QN K E Q Q QL + LL L +
Sbjct: 1260 NSKLQVDYTGLIQSYE--QNETKLKNFGQELAQVQHSIGQLCNTKDLLLGK---LDIISP 1314
Query: 1180 RQSAEYEALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAELEEREKVLTTEREALQQ 1239
+ S+ + CL+ + E EL ++ ELEE R++LQ+
Sbjct: 1315 QLSSASLLTPQSAECLRASKSEVLSESSELLQQ---------ELEEL-------RKSLQE 1358
Query: 1240 EQRTNALAMGENQRLRGELDRVNFLHHQLKGEYEELHAHTKELKTSLNNAQLELNRWQAR 1299
+ T N RL + + L + E+E+ + K+LK + Q L
Sbjct: 1359 KDATIRTLQENNHRLSDSIAATSELERK---EHEQTDSEIKQLKEKQDVLQKLLKEKDLL 1415
Query: 1300 FDELKEQHQTMDISLTKLDNHCELLSRLKGNLEEENHHLLSQIQLLSQQNQMLLEQNMEN 1359
+Q + + + T N ELL + NL+E L I L +N+ ++E
Sbjct: 1416 IKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGK 1475
Query: 1360 KEQYHEEQKQYIDKLNALRRHKEKLEEKIMDQYKFYDPPPKKKNHWIGAKALVKLIKPKK 1419
+ +Y Q+ + K + + R KE F K+K A A +L+K K+
Sbjct: 1476 ETEYQALQETNM-KFSMMLREKE-----------FECHSMKEK-----ALAFEQLLKEKE 1518
Query: 1420 EGSRERLKSTVDS 1432
+G L +++
Sbjct: 1519 QGKTGELNQLLNA 1531
Score = 132 bits (331), Expect = 4e-30
Identities = 290/1366 (21%), Positives = 549/1366 (40%), Gaps = 198/1366 (14%)
Query: 176 ELPDVAPEELEALSRSMVLHLRRLIDQRDECTELIVDLTQE-RDYLQAQHPPSPIKSSSA 234
E+ ++ + EA ++ M+L +L Q++E +I L Q+ D + H
Sbjct: 496 EIEELDRQNQEA-TKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVH-------QLE 547
Query: 235 DSTPSPTSSLSSEDKQHLAVELADTKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQKV 294
D T L + ++ + E+A L +Q+LEDK E LVD ++ + + +QK
Sbjct: 548 DDKMDITKELDVQKEKLIQSEVALNDLHL--TKQKLEDKVENLVDQLNKSQESNVSIQK- 604
Query: 295 KQENIQLAADARS-----ARAYRDELDSLREKANR------VERLELELTRCKEKLHDVD 343
EN++L R +R + + SL + +N ++ E E+ K+ L +++
Sbjct: 605 --ENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELE 662
Query: 344 FYKARME----ELREDNIILIETKAMLEEQLTAARARGDKVHELEKENL--QLKSKLHDL 397
++ +++ +N L+ + QL A G+ LEK + LK + ++
Sbjct: 663 QLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLA-GNNQLSLEKNTIVETLKMEKGEI 721
Query: 398 ELDRDTDKKRIEELLE--ENMVLEIAQKQSMNESA------HL-------GWELEQLSKN 442
E + KKR+ E E + E++ +++N SA HL E+ +L KN
Sbjct: 722 EAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKN 781
Query: 443 ADLSDASRKSFVFELNECASSR-------------ILKLEKENQSLQSTI----QGLRDA 485
+ D K L+ + I KL++ + LQ + Q LR
Sbjct: 782 IEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKN 841
Query: 486 SLV---LEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQ----DLETLSE--ELIR 536
++ +EE G +++EN+ L +++E+L RE+QS D +TL EL
Sbjct: 842 EILRQTIEEKDRSLGSMKEENNHLQEELERL-----REEQSRTAPVADPKTLDSVTELAS 896
Query: 537 EKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALH 596
E QL + E L+ + K +E + + + SL+E+ + E R + E+ N
Sbjct: 897 EVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQH-EQMNATHT 955
Query: 597 QTVTEANGKLSQL----EFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGRLARKVT 652
Q E + ++ L E K QLH + + + + E ++Q L ENG ++
Sbjct: 956 QLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQ-ETKVQSLNIENGSEKHDLS 1014
Query: 653 SLETA--TEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELR 710
ET + ++ E E + L +N +L K +D L + K L+ + L R
Sbjct: 1015 KAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHAR 1074
Query: 711 RLVETMRFTSTKLAQMERENQQLEREK------EELRKNVDLLKALGKKSERL---ELSY 761
+ T Q + + +EREK E+ R+N L K + + E +
Sbjct: 1075 -ISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAAL 1133
Query: 762 QSVSAENLRLQQSLESSSHKT-----QTLESELGELEAERQALRRDLEALRLA------- 809
+ EN +L ESS Q L + E + E AL + + L
Sbjct: 1134 IKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTG 1193
Query: 810 -------NAQLEGAEKDRKALEQEVAQLEKDKKL-------LEKEAKRLWQQV-ELKDAV 854
+ Q E ++R L+Q+V ++E+ K+ ++ E+ +L +++ +L+ V
Sbjct: 1194 NEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQV 1253
Query: 855 LDDS----------TAKLSAVEKESRALD---KELARCRDAAGKL---KELEKDNRDLTK 898
L DS T + + E+ L +ELA+ + + G+L K+L D+
Sbjct: 1254 LVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIIS 1313
Query: 899 QVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRE------LLLQEDD-- 950
A LT + L KS+ LS + L QELE++ + + LQE++
Sbjct: 1314 PQLSSASLLTPQSAEC-LRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNHR 1372
Query: 951 -SGSDTKYKILEGRNESALKTTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLKKECET 1009
S S LE + + + +EK +L+ ++EK L + +L + E T
Sbjct: 1373 LSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQL-LSSNENFT 1431
Query: 1010 LRQNQGE--GQHLQN-------------SFKHPAGKTAASHQGKEAWGPGHKEATMEL-L 1053
+ N+ E Q + N K K +++GKE +E M+ +
Sbjct: 1432 NKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSM 1491
Query: 1054 RVKDRAIELERNNAALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEHNTTLQT 1113
++++ E A +QLLKE+ Q + + + ++Q+++ Q+ +
Sbjct: 1492 MLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVML 1551
Query: 1114 QTAKLQVENSTLSSQSAAL-------TAQYTLLQNHHTAKETE--NESLQRQQEQLTAAY 1164
+ Q+EN+ L ++ L + L+NH E E+L + +
Sbjct: 1552 ALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAEDREAKLRK 1611
Query: 1165 EALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAELE 1224
+ + + + + + + ++A ++A ++ +++L L + K+ E + + +++
Sbjct: 1612 KVTVLEEKLVSSSNAMENASHQASVQ----VESLQEQLNVVSKQRDETALQLSVSQEQVK 1667
Query: 1225 EREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQLKGEYEELHAHTKELKT 1284
+ L + L+ Q+ E EL++ L + K E L L+
Sbjct: 1668 QYALSLANLQMVLEHFQQE------EKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQE 1721
Query: 1285 SLNNAQLELNRWQARFDELKEQHQTMDISLTKLDNHCELLSRLKGNLEEENHHLLSQIQL 1344
L+ A L+ L EQ + + +L EL + L++ L+S
Sbjct: 1722 CLDEANAALD----SASRLTEQLDVKEEQIEELKRQNELRQEM---LDDVQKKLMSLANS 1774
Query: 1345 LSQQNQMLLEQNM------ENKEQYHEEQKQYIDKLNALRRHKEKL 1384
+ +L +N+ K Q HE + L R E+L
Sbjct: 1775 SEGKVDKVLMRNLFIGHFHTPKNQRHEVLRLMGSILGVRREEMEQL 1820
Score = 128 bits (322), Expect = 5e-29
Identities = 271/1265 (21%), Positives = 543/1265 (42%), Gaps = 200/1265 (15%)
Query: 262 RLRRVRQEL-EDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSARAYRDELDSLRE 320
+L+ + +EL +++++++ D +HE+ L Q Q+ + +R +R+EL E
Sbjct: 213 KLQNIIKELKQNRSQEIDDHQHEMSVL----QNAHQQKL-----TEISRRHREELSDYEE 263
Query: 321 KANRVERL---------ELELTRCKEKLHDVDFYKA-------RMEELREDNIILIETKA 364
+ +E L E +L++ E + + +ME+L ED I I K
Sbjct: 264 RIEELENLLQQGGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQL-EDKIKDINKKL 322
Query: 365 MLEEQLTAARARGDKVHELEK-------ENLQLK-SKLHDLEL---DRDTDKKRIEELLE 413
E R + +EK ENL+L+ SKL + D T+K+RI L +
Sbjct: 323 SSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERI--LAQ 380
Query: 414 ENMVLEIAQ-KQSMNESAHLGWELEQLSKNADLSDASRK-SFVFELNECASSRILKLEKE 471
V E+ + +Q+++++ + L L+++ L++ + K E+ E S L +E
Sbjct: 381 SASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSL---LSQE 437
Query: 472 NQSLQSTIQGLRDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLS 531
+ LQ ++ L + V++ + + L+ E H L +E +E++ NQ
Sbjct: 438 KEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLE------AKEQELNQS----- 486
Query: 532 EELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKE 591
I EKE L +++E L K + KD L++ E + S+ + +D+ E
Sbjct: 487 ---ISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQ---NEGDSIISKLK-QDLNDE 539
Query: 592 NKALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEE-NGRLARK 650
K +H QLE +K + ++L+ KEK ++E +L +++ ++
Sbjct: 540 KKRVH-----------QLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENL 588
Query: 651 VTSLETATEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELR 710
V L + E +++ E+ L+ R + L ++N +Q L +D+ + L
Sbjct: 589 VDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQ--SLNQDSNSNFKDTLLKE 646
Query: 711 RLVETMRFTSTKLAQMERENQQLEREKEELR-KNVDLLKALGKKSERLELSYQSVSAENL 769
R E +R L+++E+ N+ L++ +++ +N L+ A +LE + ++ N
Sbjct: 647 REAE-VRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLE---ECLAGNN- 701
Query: 770 RLQQSLESSSHKTQTLESELGELEAER-QALRRDLEALRLANAQLEGAEKDR----KALE 824
Q SLE ++ +TL+ E GE+EAE A +R LE +E R AL+
Sbjct: 702 --QLSLEKNT-IVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQ 758
Query: 825 QEVAQLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRAL-----DKE--LA 877
E L K + + E L + +E D ++ LS+ +E + L KE +
Sbjct: 759 LEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIE 818
Query: 878 RCRDAAGKL-KELEK------DNRDLTKQVTVHARTLTTLRED-----LVLEKLKSQQLS 925
+ ++ + KL +EL+K N L + + R+L +++E+ LE+L+ +Q
Sbjct: 819 KLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSR 878
Query: 926 S----------ELDKLSQELEKVGLNRELLLQEDDSGSDTKYKILEGRNESALKTTLAMK 975
+ + +L+ E+ ++ +E L +E KI+E +N+S ++ +++
Sbjct: 879 TAPVADPKTLDSVTELASEVSQLNTIKEHLEEE----IKHHQKIIEDQNQSKMQLLQSLQ 934
Query: 976 EEKIVLLE--AQMEEKASLNRQL----ESELQMLKKECETLR-QNQGEGQHLQNS----F 1024
E+K + E Q E+ + + QL + E++ L+K E ++ Q E Q +Q F
Sbjct: 935 EQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIF 994
Query: 1025 KHPAGKTAASHQGKEAWGPGHKEATMELLRVKDRAIEL----ERNNAALQAEKQLLKE-- 1078
+ ++ G E E + +K+R +E+ E+N + + QL K+
Sbjct: 995 QETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEV 1054
Query: 1079 -------QLQHLETQNVTFSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQSAA 1131
Q + LE Q + + + +LQ+ + K+ + + +++
Sbjct: 1055 GKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSH 1114
Query: 1132 LTAQYTLLQNHHTAKETENESLQRQQEQLTAAYEALLQDH-----EHLGTLHERQSAEYE 1186
L +Y + + AKE LQ + ++L+ +E+ QD ++L + + E +
Sbjct: 1115 LKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEID 1174
Query: 1187 ALIRQHSCLKTLHRNLEL----------EHKELGERHGDMLKRKAELEE-REKVLTTERE 1235
AL ++ L + + + +EL + + ++ ++EE +++V+TT
Sbjct: 1175 ALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTT--- 1231
Query: 1236 ALQQEQRTNALAMGENQRLRGELDRVNFLHHQLKGEYEELHAHTKELKTSLNNAQLELNR 1295
+Q Q +A E +L+ ++ + + +L+ +Y L ++ +T L N EL +
Sbjct: 1232 -VQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQ 1290
Query: 1296 WQARFDELKEQHQTMDISLTKLD--------------NHCELLSRLKGNLEEENHHLLSQ 1341
Q +L T D+ L KLD E L K + E+ LL Q
Sbjct: 1291 VQHSIGQL---CNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQ 1347
Query: 1342 ---------------IQLLSQQNQMLLEQNMENKEQYHEEQKQYIDKLNALRRHKEKLEE 1386
I+ L + N L + E +E +Q ++ L+ ++ L++
Sbjct: 1348 ELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQK 1407
Query: 1387 KIMDQ 1391
+ ++
Sbjct: 1408 LLKEK 1412
Score = 105 bits (263), Expect = 3e-22
Identities = 234/1173 (19%), Positives = 484/1173 (41%), Gaps = 210/1173 (17%)
Query: 109 RDPLSGKSMEEIKKVLLLVLGCAVQCERKEEFIERIKQLDIETQAGIVAHIQEVTHNQEN 168
+D LS S+EE K++ L+ +KE FIE++K+ + Q + + Q + N+
Sbjct: 793 KDVLSS-SLEEQKQLTQLI-------NKKEIFIEKLKERSSKLQEELDKYSQALRKNE-- 842
Query: 169 VFDLQWLELPDVAPEELEALSRSMVLHLRRLIDQRDECTELIVDLTQERDYLQAQHPPSP 228
LR+ I+++D + + +E ++LQ +
Sbjct: 843 --------------------------ILRQTIEEKDRS---LGSMKEENNHLQEELE--- 870
Query: 229 IKSSSADSTPSPTSSLSSEDKQHLAVELADTKARLRRVRQELEDKTEQ----LVDTRHEV 284
+ S +P + + D ELA ++L +++ LE++ + + D
Sbjct: 871 -RLREEQSRTAPVADPKTLDS---VTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSK 926
Query: 285 DQLVLELQKVKQENIQLAADARSARAYRDELDSLREKANRVERLELELTRCKEKLHDVDF 344
QL+ LQ+ K+E + A +L EK ++ L+ + + K +LH+
Sbjct: 927 MQLLQSLQEQKKEMDEFRYQHEQMNATHTQL--FLEKDEEIKSLQKTIEQIKTQLHE--- 981
Query: 345 YKARMEELREDNI-ILIETKAM------------LEEQLTAARARGDKVHELE-----KE 386
++++ DN I ETK L + T +G K ELE ++
Sbjct: 982 ---ERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEK 1038
Query: 387 NLQLKSKLHDLELDRDTDKKRIEELLEENMVLEIAQKQSMNESAHL-----------GWE 435
N+ L ++ L D + ++ +++++ + A ++ ++H +
Sbjct: 1039 NISLTKQIDQLSKD---EVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYA 1095
Query: 436 LEQLSKNADLSDASRKSF--------VFELNECASSRILKLEKENQSLQSTIQG------ 481
+E+ A L++ +R++ + ++ + ++KL+ EN+ L + +
Sbjct: 1096 MEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMF 1155
Query: 482 ---LRDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREK 538
+++ S ++ E ++ L ++ L ++ T E ++ E L +E + K
Sbjct: 1156 RETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLK 1215
Query: 539 EQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQT 598
+Q++ ME K +++++ E L + L+ + V S+ K ++ + L Q+
Sbjct: 1216 QQVKK-MEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSK-LQVDYTGLIQS 1273
Query: 599 VTEANGKLSQLEFEKRQLHRDLEQ-AKEKGERAEKLERELQRLQEENGRLARKVTSLETA 657
+ KL E Q+ + Q K KL+ +L + + L +
Sbjct: 1274 YEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRAS 1333
Query: 658 TEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVETMR 717
K E L S+ LQ E LRKS LQ + L+ +N RL +++
Sbjct: 1334 --KSEVLSESSELLQQELEELRKS---LQEKDATIRTLQENN----------HRLSDSIA 1378
Query: 718 FTSTKLAQMER-ENQQLEREKEELRKNVDLLKALGK--------KSERLELSYQSVS--- 765
TS ++ER E++Q + E ++L++ D+L+ L K KS++L S ++ +
Sbjct: 1379 ATS----ELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKV 1434
Query: 766 AENLRLQQSLESSSHKTQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQ 825
EN L+Q++ + + LE ++G+L+ E + + +E R G E + +AL++
Sbjct: 1435 NENELLRQAVTNLKERILILEMDIGKLKGENEKI---VETYR-------GKETEYQALQE 1484
Query: 826 EVAQLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGK 885
++ L EKE + + K A+ E +KE + G+
Sbjct: 1485 --TNMKFSMMLREKE--------------FECHSMKEKALAFEQLLKEKEQGK----TGE 1524
Query: 886 LKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKL-------SQELEKV 938
L +L + + ++ V + + L +++++ L +E+ +L +QELE++
Sbjct: 1525 LNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERL 1584
Query: 939 GLNRELLLQEDDSGSDTKYKILEGRNESALKTTLAMKEEKIVLLEAQMEEKASLNRQLES 998
R LL+ +D S T+ + E+ L+ + + EEK+V ME + + Q
Sbjct: 1585 ---RNHLLESED--SYTREALAAEDREAKLRKKVTVLEEKLVSSSNAME---NASHQASV 1636
Query: 999 ELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEATMELLRVKDR 1058
+++ L+++ + + + E LQ S K + A + + +E + +++
Sbjct: 1637 QVESLQEQLNVVSKQRDE-TALQLSVSQEQVK-------QYALSLANLQMVLEHFQQEEK 1688
Query: 1059 AIELERNNAALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEHNTTLQTQTAKL 1118
A+ +A L+ +KQL+ E ++ E ++++LQ+ L E N L + ++L
Sbjct: 1689 AM----YSAELEKQKQLIAEWKKNAE----NLEGKVISLQE---CLDEANAALDS-ASRL 1736
Query: 1119 QVENSTLSSQSAALTAQYTLLQNHHTAKETENESLQRQQEQLTAAYEALLQDHEHLGTLH 1178
+ Q L Q L Q + + SL E + +L + +G H
Sbjct: 1737 TEQLDVKEEQIEELKRQNELRQEMLDDVQKKLMSLANSSE---GKVDKVLMRNLFIGHFH 1793
Query: 1179 ERQSAEYEALIRQHSCLKTLHRNLE-LEHKELG 1210
++ +E L S L +E L H + G
Sbjct: 1794 TPKNQRHEVLRLMGSILGVRREEMEQLFHDDQG 1826
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.126 0.343
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 78,807,002
Number of Sequences: 37866
Number of extensions: 4151212
Number of successful extensions: 54669
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 553
Number of HSP's successfully gapped in prelim test: 2124
Number of HSP's that attempted gapping in prelim test: 21204
Number of HSP's gapped (non-prelim): 15357
length of query: 2028
length of database: 18,247,518
effective HSP length: 118
effective length of query: 1910
effective length of database: 13,779,330
effective search space: 26318520300
effective search space used: 26318520300
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.