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Search of human proteins with 148728162
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|148728162 protein tyrosine phosphatase, receptor type, J
isoform 1 precursor [Homo sapiens]
(1337 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|148728162 protein tyrosine phosphatase, receptor type, J isof... 2712 0.0
gi|148728160 protein tyrosine phosphatase, receptor type, J isof... 1079 0.0
gi|157952215 protein tyrosine phosphatase, receptor type, B isof... 428 e-119
gi|157952213 protein tyrosine phosphatase, receptor type, B isof... 428 e-119
gi|241896924 protein tyrosine phosphatase, receptor type, H isof... 387 e-107
gi|241896926 protein tyrosine phosphatase, receptor type, H isof... 362 1e-99
gi|4506323 receptor-type protein tyrosine phosphatase O isoform ... 284 3e-76
gi|13677220 receptor-type protein tyrosine phosphatase O isoform... 279 1e-74
gi|13677216 receptor-type protein tyrosine phosphatase O isoform... 279 1e-74
gi|13677222 receptor-type protein tyrosine phosphatase O isoform... 278 3e-74
gi|13677218 receptor-type protein tyrosine phosphatase O isoform... 278 3e-74
gi|13677214 receptor-type protein tyrosine phosphatase O isoform... 278 3e-74
gi|18860894 protein tyrosine phosphatase, receptor type, D isofo... 274 5e-73
gi|104487002 protein tyrosine phosphatase, receptor type, D isof... 269 1e-71
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo... 269 1e-71
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor... 266 8e-71
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo... 266 8e-71
gi|104487611 protein tyrosine phosphatase, receptor type, sigma ... 258 3e-68
gi|104487295 protein tyrosine phosphatase, receptor type, sigma ... 258 3e-68
gi|222537743 protein tyrosine phosphatase, receptor type, Q [Hom... 256 8e-68
gi|148539860 protein tyrosine phosphatase, receptor type, T isof... 247 6e-65
gi|148539858 protein tyrosine phosphatase, receptor type, T isof... 247 6e-65
gi|157419150 protein tyrosine phosphatase, receptor type, M isof... 244 3e-64
gi|157419152 protein tyrosine phosphatase, receptor type, M isof... 244 3e-64
gi|104487297 protein tyrosine phosphatase, receptor type, sigma ... 243 7e-64
gi|109633039 protein tyrosine phosphatase, receptor type, F isof... 239 1e-62
gi|109633041 protein tyrosine phosphatase, receptor type, F isof... 238 2e-62
gi|104487006 protein tyrosine phosphatase, receptor type, sigma ... 233 9e-61
gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1 p... 233 1e-60
gi|194097398 protein tyrosine phosphatase, receptor type, G prec... 231 3e-60
>gi|148728162 protein tyrosine phosphatase, receptor type, J isoform 1
precursor [Homo sapiens]
Length = 1337
Score = 2712 bits (7029), Expect = 0.0
Identities = 1337/1337 (100%), Positives = 1337/1337 (100%)
Query: 1 MKPAAREARLPPRSPGLRWALPLLLLLLRLGQILCAGGTPSPIPDPSVATVATGENGITQ 60
MKPAAREARLPPRSPGLRWALPLLLLLLRLGQILCAGGTPSPIPDPSVATVATGENGITQ
Sbjct: 1 MKPAAREARLPPRSPGLRWALPLLLLLLRLGQILCAGGTPSPIPDPSVATVATGENGITQ 60
Query: 61 ISSTAESFHKQNGTGTPQVETNTSEDGESSGANDSLRTPEQGSNGTDGASQKTPSSTGPS 120
ISSTAESFHKQNGTGTPQVETNTSEDGESSGANDSLRTPEQGSNGTDGASQKTPSSTGPS
Sbjct: 61 ISSTAESFHKQNGTGTPQVETNTSEDGESSGANDSLRTPEQGSNGTDGASQKTPSSTGPS 120
Query: 121 PVFDIKAVSISPTNVILTWKSNDTAASEYKYVVKHKMENEKTITVVHQPWCNITGLRPAT 180
PVFDIKAVSISPTNVILTWKSNDTAASEYKYVVKHKMENEKTITVVHQPWCNITGLRPAT
Sbjct: 121 PVFDIKAVSISPTNVILTWKSNDTAASEYKYVVKHKMENEKTITVVHQPWCNITGLRPAT 180
Query: 181 SYVFSITPGIGNETWGDPRVIKVITEPIPVSDLRVALTGVRKAALSWSNGNGTASCRVLL 240
SYVFSITPGIGNETWGDPRVIKVITEPIPVSDLRVALTGVRKAALSWSNGNGTASCRVLL
Sbjct: 181 SYVFSITPGIGNETWGDPRVIKVITEPIPVSDLRVALTGVRKAALSWSNGNGTASCRVLL 240
Query: 241 ESIGSHEELTQDSRLQVNISGLKPGVQYNINPYLLQSNKTKGDPLGTEGGLDASNTERSR 300
ESIGSHEELTQDSRLQVNISGLKPGVQYNINPYLLQSNKTKGDPLGTEGGLDASNTERSR
Sbjct: 241 ESIGSHEELTQDSRLQVNISGLKPGVQYNINPYLLQSNKTKGDPLGTEGGLDASNTERSR 300
Query: 301 AGSPTAPVHDESLVGPVDPSSGQQSRDTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAI 360
AGSPTAPVHDESLVGPVDPSSGQQSRDTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAI
Sbjct: 301 AGSPTAPVHDESLVGPVDPSSGQQSRDTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAI 360
Query: 361 EFRTNAIQVFDVTAVNISATSLTLIWKVSDNESSSNYTYKIHVAGETDSSNLNVSEPRAV 420
EFRTNAIQVFDVTAVNISATSLTLIWKVSDNESSSNYTYKIHVAGETDSSNLNVSEPRAV
Sbjct: 361 EFRTNAIQVFDVTAVNISATSLTLIWKVSDNESSSNYTYKIHVAGETDSSNLNVSEPRAV 420
Query: 421 IPGLRSSTFYNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDAE 480
IPGLRSSTFYNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDAE
Sbjct: 421 IPGLRSSTFYNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDAE 480
Query: 481 SFQMHITQEGAGNSRVEITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTVP 540
SFQMHITQEGAGNSRVEITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTVP
Sbjct: 481 SFQMHITQEGAGNSRVEITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTVP 540
Query: 541 SAVFDIHVVYVTTTEMWLDWKSPDGASEYVYHLVIESKHGSNHTSTYDKAITLQGLIPGT 600
SAVFDIHVVYVTTTEMWLDWKSPDGASEYVYHLVIESKHGSNHTSTYDKAITLQGLIPGT
Sbjct: 541 SAVFDIHVVYVTTTEMWLDWKSPDGASEYVYHLVIESKHGSNHTSTYDKAITLQGLIPGT 600
Query: 601 LYNITISPEVDHVWGDPNSTAQYTRPSNVSNIDVSTNTTAATLSWQNFDDASPTYSYCLL 660
LYNITISPEVDHVWGDPNSTAQYTRPSNVSNIDVSTNTTAATLSWQNFDDASPTYSYCLL
Sbjct: 601 LYNITISPEVDHVWGDPNSTAQYTRPSNVSNIDVSTNTTAATLSWQNFDDASPTYSYCLL 660
Query: 661 IEKAGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQVGDGIKSLEPGRKSFCTDPA 720
IEKAGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQVGDGIKSLEPGRKSFCTDPA
Sbjct: 661 IEKAGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQVGDGIKSLEPGRKSFCTDPA 720
Query: 721 SMASFDCEVVPKEPALVLKWTCPPGANAGFELEVSSGAWNNATHLESCSSENGTEYRTEV 780
SMASFDCEVVPKEPALVLKWTCPPGANAGFELEVSSGAWNNATHLESCSSENGTEYRTEV
Sbjct: 721 SMASFDCEVVPKEPALVLKWTCPPGANAGFELEVSSGAWNNATHLESCSSENGTEYRTEV 780
Query: 781 TYLNFSTSYNISITTVSCGKMAAPTRNTCTTGITDPPPPDGSPNITSVSHNSVKVKFSGF 840
TYLNFSTSYNISITTVSCGKMAAPTRNTCTTGITDPPPPDGSPNITSVSHNSVKVKFSGF
Sbjct: 781 TYLNFSTSYNISITTVSCGKMAAPTRNTCTTGITDPPPPDGSPNITSVSHNSVKVKFSGF 840
Query: 841 EASHGPIKAYAVILTTGEAGHPSADVLKYTYEDFKKGASDTYVTYLIRTEEKGRSQSLSE 900
EASHGPIKAYAVILTTGEAGHPSADVLKYTYEDFKKGASDTYVTYLIRTEEKGRSQSLSE
Sbjct: 841 EASHGPIKAYAVILTTGEAGHPSADVLKYTYEDFKKGASDTYVTYLIRTEEKGRSQSLSE 900
Query: 901 VLKYEIDVGNESTTLGYYNGKLEPLGSYRACVAGFTNITFHPQNKGLIDGAESYVSFSRY 960
VLKYEIDVGNESTTLGYYNGKLEPLGSYRACVAGFTNITFHPQNKGLIDGAESYVSFSRY
Sbjct: 901 VLKYEIDVGNESTTLGYYNGKLEPLGSYRACVAGFTNITFHPQNKGLIDGAESYVSFSRY 960
Query: 961 SDAVSLPQDPGVICGAVFGCIFGALVIVTVGGFIFWRKKRKDAKNNEVSFSQIKPKKSKL 1020
SDAVSLPQDPGVICGAVFGCIFGALVIVTVGGFIFWRKKRKDAKNNEVSFSQIKPKKSKL
Sbjct: 961 SDAVSLPQDPGVICGAVFGCIFGALVIVTVGGFIFWRKKRKDAKNNEVSFSQIKPKKSKL 1020
Query: 1021 IRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDIS 1080
IRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDIS
Sbjct: 1021 IRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDIS 1080
Query: 1081 RVKLSVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTK 1140
RVKLSVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTK
Sbjct: 1081 RVKLSVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTK 1140
Query: 1141 CVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHF 1200
CVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHF
Sbjct: 1141 CVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHF 1200
Query: 1201 TSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIE 1260
TSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIE
Sbjct: 1201 TSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIE 1260
Query: 1261 NENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQKDSKVDLIYQNTTAMTIY 1320
NENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQKDSKVDLIYQNTTAMTIY
Sbjct: 1261 NENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQKDSKVDLIYQNTTAMTIY 1320
Query: 1321 ENLAPVTTFGKTNGYIA 1337
ENLAPVTTFGKTNGYIA
Sbjct: 1321 ENLAPVTTFGKTNGYIA 1337
>gi|148728160 protein tyrosine phosphatase, receptor type, J isoform
2 precursor [Homo sapiens]
Length = 539
Score = 1079 bits (2791), Expect = 0.0
Identities = 538/538 (100%), Positives = 538/538 (100%)
Query: 1 MKPAAREARLPPRSPGLRWALPLLLLLLRLGQILCAGGTPSPIPDPSVATVATGENGITQ 60
MKPAAREARLPPRSPGLRWALPLLLLLLRLGQILCAGGTPSPIPDPSVATVATGENGITQ
Sbjct: 1 MKPAAREARLPPRSPGLRWALPLLLLLLRLGQILCAGGTPSPIPDPSVATVATGENGITQ 60
Query: 61 ISSTAESFHKQNGTGTPQVETNTSEDGESSGANDSLRTPEQGSNGTDGASQKTPSSTGPS 120
ISSTAESFHKQNGTGTPQVETNTSEDGESSGANDSLRTPEQGSNGTDGASQKTPSSTGPS
Sbjct: 61 ISSTAESFHKQNGTGTPQVETNTSEDGESSGANDSLRTPEQGSNGTDGASQKTPSSTGPS 120
Query: 121 PVFDIKAVSISPTNVILTWKSNDTAASEYKYVVKHKMENEKTITVVHQPWCNITGLRPAT 180
PVFDIKAVSISPTNVILTWKSNDTAASEYKYVVKHKMENEKTITVVHQPWCNITGLRPAT
Sbjct: 121 PVFDIKAVSISPTNVILTWKSNDTAASEYKYVVKHKMENEKTITVVHQPWCNITGLRPAT 180
Query: 181 SYVFSITPGIGNETWGDPRVIKVITEPIPVSDLRVALTGVRKAALSWSNGNGTASCRVLL 240
SYVFSITPGIGNETWGDPRVIKVITEPIPVSDLRVALTGVRKAALSWSNGNGTASCRVLL
Sbjct: 181 SYVFSITPGIGNETWGDPRVIKVITEPIPVSDLRVALTGVRKAALSWSNGNGTASCRVLL 240
Query: 241 ESIGSHEELTQDSRLQVNISGLKPGVQYNINPYLLQSNKTKGDPLGTEGGLDASNTERSR 300
ESIGSHEELTQDSRLQVNISGLKPGVQYNINPYLLQSNKTKGDPLGTEGGLDASNTERSR
Sbjct: 241 ESIGSHEELTQDSRLQVNISGLKPGVQYNINPYLLQSNKTKGDPLGTEGGLDASNTERSR 300
Query: 301 AGSPTAPVHDESLVGPVDPSSGQQSRDTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAI 360
AGSPTAPVHDESLVGPVDPSSGQQSRDTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAI
Sbjct: 301 AGSPTAPVHDESLVGPVDPSSGQQSRDTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAI 360
Query: 361 EFRTNAIQVFDVTAVNISATSLTLIWKVSDNESSSNYTYKIHVAGETDSSNLNVSEPRAV 420
EFRTNAIQVFDVTAVNISATSLTLIWKVSDNESSSNYTYKIHVAGETDSSNLNVSEPRAV
Sbjct: 361 EFRTNAIQVFDVTAVNISATSLTLIWKVSDNESSSNYTYKIHVAGETDSSNLNVSEPRAV 420
Query: 421 IPGLRSSTFYNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDAE 480
IPGLRSSTFYNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDAE
Sbjct: 421 IPGLRSSTFYNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDAE 480
Query: 481 SFQMHITQEGAGNSRVEITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRT 538
SFQMHITQEGAGNSRVEITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRT
Sbjct: 481 SFQMHITQEGAGNSRVEITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRT 538
Score = 108 bits (271), Expect = 3e-23
Identities = 105/406 (25%), Positives = 165/406 (40%), Gaps = 64/406 (15%)
Query: 332 LVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQVFDVTAVNISATSLTLIWKVSDN 391
+ GL P T Y ++ N T G P+ I+ T I V D+ L W
Sbjct: 173 ITGLRPATSYVFSITPGIGNETWGDPRVIKVITEPIPVSDLRVALTGVRKAALSW----- 227
Query: 392 ESSSNYTYKIHVAGETDSSNLNVSEPRAV---IPGLRSSTFYNITVCPVL-------GDI 441
S+ N T V E+ S+ +++ + I GL+ YNI P L GD
Sbjct: 228 -SNGNGTASCRVLLESIGSHEELTQDSRLQVNISGLKPGVQYNIN--PYLLQSNKTKGDP 284
Query: 442 EGTPGFLQVH--------TPPVPVSDFRVTVVSTTEIGLAWSSHDAESFQMHITQEGAGN 493
GT G L +P PV D ++V + S D E
Sbjct: 285 LGTEGGLDASNTERSRAGSPTAPVHD--ESLVGPVDPSSGQQSRDTE------------- 329
Query: 494 SRVEITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTVPSAVFDIHVVYVTT 553
+++ GL PGT+Y + + NGTEG + + RT VFD+ V ++
Sbjct: 330 ----------VLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQVFDVTAVNISA 379
Query: 554 TEMWLDWKSPD--GASEYVYHLVIESKHGSNHTSTYDKAITLQGLIPGTLYNITISPEVD 611
T + L WK D +S Y Y + + + S++ + + + GL T YNIT+ P +
Sbjct: 380 TSLTLIWKVSDNESSSNYTYKIHVAGETDSSNLNVSEPRAVIPGLRSSTFYNITVCPVLG 439
Query: 612 HVWGDPNSTAQYTRPSNVSNIDVS-TNTTAATLSWQNFDDASPTYSYCLLIEKAGNSSNA 670
+ G P +T P VS+ V+ +TT L+W + D S+ + I + G ++
Sbjct: 440 DIEGTPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHD----AESFQMHITQEGAGNSR 495
Query: 671 TQVVTDIGITDATVTELIPGSSYTVEIFAQVGDGIKSLEPGRKSFC 716
++ T+ I + L PG+ Y EI V G E ++ C
Sbjct: 496 VEITTNQSI---IIGGLFPGTKYCFEI---VPKGPNGTEGASRTVC 535
Score = 106 bits (265), Expect = 1e-22
Identities = 81/245 (33%), Positives = 114/245 (46%), Gaps = 17/245 (6%)
Query: 454 PVPVSDFRVTVVSTTEIGLAWSSHDAESFQMHITQEGAGNSRVEITTNQSIIIGGLFPGT 513
P P+ D V V+T E G+ S AESF Q G G +VE T++ G G
Sbjct: 40 PSPIPDPSVATVATGENGITQISSTAESFHK---QNGTGTPQVETNTSED----GESSGA 92
Query: 514 KYCFEIVPKGPNGTEGASRTVCNRTVPSAVFDIHVVYVTTTEMWLDWKSPD-GASEYVYH 572
+G NGT+GAS+ + T PS VFDI V ++ T + L WKS D ASEY Y
Sbjct: 93 NDSLRTPEQGSNGTDGASQKTPSSTGPSPVFDIKAVSISPTNVILTWKSNDTAASEYKYV 152
Query: 573 LVIESKHGSNHTSTYDKAITLQGLIPGTLYNITISPEV-DHVWGDPNSTAQYTRPSNVSN 631
+ + ++ T + + GL P T Y +I+P + + WGDP T P VS+
Sbjct: 153 VKHKMENEKTITVVHQPWCNITGLRPATSYVFSITPGIGNETWGDPRVIKVITEPIPVSD 212
Query: 632 IDVS-TNTTAATLSWQNFDDASPTYSYCLLIEKAGNSSNATQVVTDIGITDATVTELIPG 690
+ V+ T A LSW N + T S +L+E G+ TQ ++ L PG
Sbjct: 213 LRVALTGVRKAALSWSN---GNGTASCRVLLESIGSHEELTQ----DSRLQVNISGLKPG 265
Query: 691 SSYTV 695
Y +
Sbjct: 266 VQYNI 270
Score = 43.9 bits (102), Expect = 0.001
Identities = 30/86 (34%), Positives = 40/86 (46%), Gaps = 7/86 (8%)
Query: 40 PSPIPDPSVATVATGENGITQISSTAESFHK---QNGTGTPQVETNTSED----GESSGA 92
P P+ D V V+T E G+ S AESF Q G G +VE T++ G G
Sbjct: 454 PVPVSDFRVTVVSTTEIGLAWSSHDAESFQMHITQEGAGNSRVEITTNQSIIIGGLFPGT 513
Query: 93 NDSLRTPEQGSNGTDGASQKTPSSTG 118
+G NGT+GAS+ + TG
Sbjct: 514 KYCFEIVPKGPNGTEGASRTVCNRTG 539
>gi|157952215 protein tyrosine phosphatase, receptor type, B isoform a
[Homo sapiens]
Length = 2215
Score = 428 bits (1101), Expect = e-119
Identities = 371/1290 (28%), Positives = 579/1290 (44%), Gaps = 154/1290 (11%)
Query: 137 LTWKSNDTAASEYKYVVKHKMENEKTITVVH-QPWCNITGLRPATSYVFSITPGIGN--- 192
++W Y+ +K+K +T ++ + C L P Y ++T G
Sbjct: 968 VSWVHATGDFDHYEVTIKNKNNFIQTKSIPKSENECVFVQLVPGRLYSVTVTTKSGQYEA 1027
Query: 193 ETWGDPRVIKVITEPIPVSDLRVALTGVRKAALSWSNGNGTAS---CRVLLESIGSHEEL 249
G+ R I P PV DL + ++WS NG ++L +
Sbjct: 1028 NEQGNGRTI-----PEPVKDLTLRNRSTEDLHVTWSGANGDVDQYEIQLLFNDMKVFPPF 1082
Query: 250 -TQDSRLQVNISGLKPGVQYNINPYLLQSN--------------KTKGDPLGTEGGLDAS 294
++ + + L PG QY I + + K + G D+
Sbjct: 1083 HLVNTATEYRFTSLTPGRQYKILVLTISGDVQQSAFIEGFTVPSAVKNIHISPNGATDSL 1142
Query: 295 NTERSRAGSPTAPVHDESLVGPVDPSSGQQSRDT-----EVLLVGLEPGTRYNATVYSQA 349
+ G D V S S+ E LE G +Y + S
Sbjct: 1143 TVNWTPGGGDV----DSYTVSAFRHSQKVDSQTIPKHVFEHTFHRLEAGEQYQIMIAS-- 1196
Query: 350 ANGTEGQPQAIEFRTNAIQVFDVTAVNI-SATSLTLIWKVSDNESSSNYTYKIHVAGETD 408
+G+ + RT V V A N S+ SL + W+ + + Y I + E
Sbjct: 1197 VSGSLKNQINVVGRTVPASVQGVIADNAYSSYSLIVSWQKAAGVAER---YDILLLTENG 1253
Query: 409 SSNLNVSEPRAV----IPGLRSSTFYNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTV 464
N SEP L Y I + V G + + T P V+D R+T
Sbjct: 1254 ILLRNTSEPATTKQHKFEDLTPGKKYKIQILTVSGGLFSKEAQTEGRTVPAAVTDLRITE 1313
Query: 465 VSTTEIGLAWSSHDAESFQMHI---TQEGAGNSRVEITTN-QSIIIGGLFPGTKYCFEIV 520
ST + W++ + E +I +G R ++ QS L G Y IV
Sbjct: 1314 NSTRHLSFRWTASEGELSWYNIFLYNPDGNLQERAQVDPLVQSFSFQNLLQGRMYKMVIV 1373
Query: 521 PKGPNGTEGASRTVCNRTVPSAVFDIHVVYVTTTE-MWLDWKSPDGASEYVYHLVIESKH 579
+G + RTVP++V + TT+ +W +W G ++ Y L++ + +
Sbjct: 1374 TH--SGELSNESFIFGRTVPASVSHLRGSNRNTTDSLWFNWSPASGDFDF-YELILYNPN 1430
Query: 580 GSNHTSTYDKAIT---LQGLIPG---TLYNITISPEVDHVWGDPNSTAQYTRPSNVSNID 633
G+ + DK +T QGL+PG L+ +T S ++ + + TA + PS +S D
Sbjct: 1431 GTKKENWKDKDLTEWRFQGLVPGRKYVLWVVTHSGDLSNKVTAESRTAP-SPPSLMSFAD 1489
Query: 634 VSTNTTAATLS----WQNFDDASPTY---SYCLLIEKAGNSSNATQVVTDIGITDATVTE 686
++ + A T W +++D + + N + ++V
Sbjct: 1490 IANTSLAITWKGPPDWTDYNDFELQWLPRDALTVFNPYNNRKSEGRIVYG---------- 1539
Query: 687 LIPGSSYTVEIFAQVGDGIKSL-EPGRKSFCTDPASMASFDCEVVPKEPALVLKWTCPPG 745
L PG SY + GD K+ +P S T P + + C A+ W P
Sbjct: 1540 LRPGRSYQFNVKTVSGDSWKTYSKPIFGSVRTKPDKIQNLHCRP-QNSTAIACSWIPPDS 1598
Query: 746 ANAGFELEVSSGAWNNATHLESCSSENGTEYRTEVTYLNFST-----SYNISITTVSCGK 800
G+ +E +++ E + E + LN Y +SI S G
Sbjct: 1599 DFDGYSIECRK--------MDTQEVEFSRKLEKEKSLLNIMMLVPHKRYLVSIKVQSAGM 1650
Query: 801 MAAPTRNTCTTGITDPPPPDGSPNITS----VSHNSVK--VKFSGFEASHGPIKAYAVIL 854
+ ++ T I PPPP + +S +S+ V S F ++G +K + V++
Sbjct: 1651 TSEVVEDSTITMIDRPPPPPPHIRVNEKDVLISKSSINFTVNCSWFSDTNGAVKYFTVVV 1710
Query: 855 TTGEAG--------HPSADVLKYTYEDFKKGASDTYVTYLIRTEEKGRSQSLSEVLKYEI 906
+ HP L+Y + + Y + + E S S S + I
Sbjct: 1711 READGSDELKPEQQHPLPSYLEYRHNASIRVYQTNY--FASKCAENPNSNSKS----FNI 1764
Query: 907 DVGNESTTLG---------YYNGKLEPLGSYRACVAGFTNITFHPQNKGLIDGAESYVSF 957
+G E +LG + +G L+P +YR + FT + ++ L + + S
Sbjct: 1765 KLGAEMESLGGKCDPTQQKFCDGPLKPHTAYRISIRAFTQLF----DEDLKEFTKPLYSD 1820
Query: 958 SRYSDAVSLPQDPGVICGAVFGCIFGALVI---VTVGGFIFWRKK---RKDAKNNEVSFS 1011
+ +S ++ +P + GA+ G G +I V V + R+K ++ + +S
Sbjct: 1821 TFFSLPITTESEP--LFGAIEGVSAGLFLIGMLVAVVALLICRQKVSHGRERPSARLSIR 1878
Query: 1012 QIKP-------------KKSKLIRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQPKY 1058
+ +P K S I++ FE +F K QADSN ++EYE+LK VG +Q
Sbjct: 1879 RDRPLSVHLNLGQKGNRKTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCD 1938
Query: 1059 AAELAENRGKNRYNNVLPYDISRVKLS-VQTHSTDDYINANYMPGYHSKKDFIATQGPLP 1117
A L ENRGKNRYNN+LPYD +RVKLS V DYINA+Y+PG + ++++I TQGPLP
Sbjct: 1939 IALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLP 1998
Query: 1118 NTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQ-AQDYGDITVAMTSEIVLPE 1176
T DFW+MVWE+NV+ I+M+T+CVE+GR KC+ YWP+ Q + YGD+ + M SE VLPE
Sbjct: 1999 GTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPE 2058
Query: 1177 WTIRDFTVKNIQTSESHPL-RQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPI 1235
WTIR+F + + ++H L R FH+T WPDHGVP+TT LI F VRDY+ +SP P
Sbjct: 2059 WTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPT 2118
Query: 1236 LVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCV 1295
+VHCSAGVGRTGTFIA+DR++ Q++++++VD+YG V+DLR+HR MVQTE QYV+L+QCV
Sbjct: 2119 VVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCV 2178
Query: 1296 LDIVRSQKDSKVDLIYQNTTAMTIYENLAP 1325
D++R++K Q IYEN+ P
Sbjct: 2179 RDVLRARKLRS----EQENPLFPIYENVNP 2204
Score = 62.8 bits (151), Expect = 2e-09
Identities = 136/647 (21%), Positives = 247/647 (38%), Gaps = 109/647 (16%)
Query: 171 CNITGLRPATSYVFSITPGIGNETWGDPRVIKVITEPIPVSDLRVALTGVRKAALS--WS 228
CN+ L+ T Y F I + + R + + T+P+P + V+ +L W+
Sbjct: 298 CNLQDLQAGTIYNFRII------SLDEERTVVLQTDPLPPARFGVSKEKTTSTSLHVWWT 351
Query: 229 NGNGTASCRVLLESIGSHEELTQDSRLQVNIS-------GLKPGVQYNINPYLLQSNK-- 279
+G + + + + + Q ++Q + S L G +YNI + K
Sbjct: 352 PSSGKVTSYEV-QLFDENNQKIQGVQIQESTSWNEYTFFNLTAGSKYNIAITAVSGGKRS 410
Query: 280 --------------------TKGDPLGTEGGLDASNTERSRAGSPTAPVHDESLV---GP 316
TK + L + N ER R + D+ ++ G
Sbjct: 411 FSVYTNGSTVPSPVKDIGISTKANSLLISWSHGSGNVERYRL-----MLMDKGILVHGGV 465
Query: 317 VDPSSGQQSRDTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQVFDVTAVN 376
VD + T GL PG YN TV ++AA + + + RT ++V ++ N
Sbjct: 466 VDKHA------TSYAFHGLTPGYLYNLTVMTEAAGLQNYRWKLV--RTAPMEVSNLKVTN 517
Query: 377 I-SATSLTLIWKVSDNESSSNYTYKIHVAGETDSSNLNVS------EPRAVIPGLRSSTF 429
S TSL + W+ G DS N+ +S E R + P + + F
Sbjct: 518 DGSLTSLKVKWQ--------------RPPGNVDSYNITLSHKGTIKESRVLAPWITETHF 563
Query: 430 --------YNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTE-IGLAWS--SHD 478
Y +TV V G++ + T P V++ + ++WS + D
Sbjct: 564 KELVPGRLYQVTVSCVSGELSAQKMAVG-RTFPDKVANLEANNNGRMRSLVVSWSPPAGD 622
Query: 479 AESFQMHITQEGAGNSRVEITTNQSIII---GGLFPGTKYCFEIVPKGPNGTEGASRTVC 535
E +++ + + + + ++ + GL PG +Y E++ + +G S
Sbjct: 623 WEQYRILLFNDSVVLLNITVGKEETQYVMDDTGLVPGRQYEVEVIVE--SGNLKNSERCQ 680
Query: 536 NRTVPSAVFDIHVVYVTTTEMWLDWKSPDGASE-YVYHLVIESKHGSNHTSTYD-KAITL 593
RTVP AV + V + T + + W++P E Y+ L + + + D K T
Sbjct: 681 GRTVPLAVLQLRVKHANETSLSIMWQTPVAEWEKYIISLADRDLLLIHKSLSKDAKEFTF 740
Query: 594 QGLIPGTLYNITISPEVDHVWGDPNSTAQYTRPSNVSNIDVSTN--TTAATLSWQNFDDA 651
L+PG Y T++ + + +S T P+ V+++ V+ T++ +W
Sbjct: 741 TDLVPGRKYMATVT-SISGDLKNSSSVKGRTVPAQVTDLHVANQGMTSSLFTNWTQAQGD 799
Query: 652 SPTYSYCLLIEKAGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQVGDGIKSLE-- 709
Y L+ E + + T + + L GS Y+V + V GI S +
Sbjct: 800 VEFYQVLLIHENVVIKNESISSET----SRYSFHSLKSGSLYSV-VVTTVSGGISSRQVV 854
Query: 710 -PGRKSFCTDPASMASFDCEVVPKEPALVLKWTCPPGANAGFELEVS 755
GR T P+S++ + L + W PG +E+ +S
Sbjct: 855 VEGR----TVPSSVSGVTVNNSGRNDYLSVSWLLAPGDVDNYEVTLS 897
Score = 59.7 bits (143), Expect = 2e-08
Identities = 143/685 (20%), Positives = 262/685 (38%), Gaps = 81/685 (11%)
Query: 110 SQKTPSSTGPSPVFDIKAVSISPTNVILTWKSNDTAASEYKYVVKHKMENEKTITVVHQP 169
S++ T P V ++ + T++ + W++ A KY++ ++ + ++H+
Sbjct: 676 SERCQGRTVPLAVLQLRVKHANETSLSIMWQT--PVAEWEKYIISLA---DRDLLLIHKS 730
Query: 170 WCN------ITGLRPATSYVFSITPGIGNETWGDPRVIKVITEPIPVSDLRVALTGVRKA 223
T L P Y+ ++T G+ + +K T P V+DL VA G+ +
Sbjct: 731 LSKDAKEFTFTDLVPGRKYMATVTSISGDLK--NSSSVKGRTVPAQVTDLHVANQGMTSS 788
Query: 224 ALS-WSNGNGTASC-RVLL--ESIGSHEELTQDSRLQVNISGLKPGVQYNINPYLLQSNK 279
+ W+ G +VLL E++ E + + LK G Y++ +
Sbjct: 789 LFTNWTQAQGDVEFYQVLLIHENVVIKNESISSETSRYSFHSLKSGSLYSVVVTTVSGGI 848
Query: 280 TKGDPL-------GTEGGLDASNTERSRAGSPT---APVHDESLVGPVDPSSGQQSRDTE 329
+ + + G+ +N+ R+ S + AP G VD S D +
Sbjct: 849 SSRQVVVEGRTVPSSVSGVTVNNSGRNDYLSVSWLLAP-------GDVDNYEVTLSHDGK 901
Query: 330 VL-------------LVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQVFDVTAVN 376
V+ L PG Y T+ +++ G+ + F V V+
Sbjct: 902 VVQSLVIAKSVRECSFSSLTPGRLYTVTITTRS-----GKYENHSFSQERTVPDKVQGVS 956
Query: 377 ISATSLTLIWKVSDNESSSNYT-YKIHVAGETD---SSNLNVSEPRAVIPGLRSSTFYNI 432
+S ++ + +VS ++ ++ Y++ + + + + ++ SE V L Y++
Sbjct: 957 VSNSARSDYLRVSWVHATGDFDHYEVTIKNKNNFIQTKSIPKSENECVFVQLVPGRLYSV 1016
Query: 433 TVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDAESFQMHITQEGAG 492
TV G E T P PV D + ST ++ + WS + + Q I Q
Sbjct: 1017 TVTTKSGQYEANEQG-NGRTIPEPVKDLTLRNRSTEDLHVTWSGANGDVDQYEI-QLLFN 1074
Query: 493 NSRV-----EITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTVPSAVFDIH 547
+ +V + T L PG +Y +I+ +G S + TVPSAV +IH
Sbjct: 1075 DMKVFPPFHLVNTATEYRFTSLTPGRQY--KILVLTISGDVQQSAFIEGFTVPSAVKNIH 1132
Query: 548 V-VYVTTTEMWLDWKSPDGASEYVYHLVIESKHGSNHTSTYDKAI---TLQGLIPGTLYN 603
+ T + ++W +P G Y + + T K + T L G Y
Sbjct: 1133 ISPNGATDSLTVNW-TPGGGDVDSYTVSAFRHSQKVDSQTIPKHVFEHTFHRLEAGEQYQ 1191
Query: 604 ITISPEVDHVWGDPNSTAQYTRPSNVSNI--DVSTNTTAATLSWQNFDDASPTYSYCLLI 661
I I+ + N + T P++V + D + ++ + +SWQ + Y LL
Sbjct: 1192 IMIASVSGSLKNQINVVGR-TVPASVQGVIADNAYSSYSLIVSWQKAAGVAERYDILLLT 1250
Query: 662 EKAGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQVGDGIKSLEPGRKSFCTDPAS 721
E N ++ T +L PG Y ++I V G+ S E + T PA+
Sbjct: 1251 ENGILLRNTSEPAT---TKQHKFEDLTPGKKYKIQILT-VSGGLFSKE-AQTEGRTVPAA 1305
Query: 722 MASFDCEVVPKEPA-LVLKWTCPPG 745
+ D + L +WT G
Sbjct: 1306 VT--DLRITENSTRHLSFRWTASEG 1328
Score = 58.2 bits (139), Expect = 5e-08
Identities = 120/579 (20%), Positives = 228/579 (39%), Gaps = 75/579 (12%)
Query: 332 LVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQV--FDVTAVNISATSLTLIWKVS 389
L L+ GT YN + S + + + +T+ + F V+ ++TSL + W S
Sbjct: 300 LQDLQAGTIYNFRIISL------DEERTVVLQTDPLPPARFGVSKEKTTSTSLHVWWTPS 353
Query: 390 DNESSSNYTYKIHVAGETDSS--NLNVSEPRA----VIPGLRSSTFYNITVCPVLGDIEG 443
+ +S Y++ + E + + + E + L + + YNI + V G
Sbjct: 354 SGKVTS---YEVQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGSKYNIAITAVSGGKRS 410
Query: 444 TPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWS--SHDAESFQMHITQEG-AGNSRVEITT 500
+ T P PV D ++ + + + ++WS S + E +++ + +G + V
Sbjct: 411 FSVYTNGSTVPSPVKDIGISTKANSLL-ISWSHGSGNVERYRLMLMDKGILVHGGVVDKH 469
Query: 501 NQSIIIGGLFPGTKYCFEIVPKGPNGTEGAS----RTVCNRTVPSAVFDIHVVY-VTTTE 555
S GL PG Y ++ TE A R RT P V ++ V + T
Sbjct: 470 ATSYAFHGLTPGYLYNLTVM------TEAAGLQNYRWKLVRTAPMEVSNLKVTNDGSLTS 523
Query: 556 MWLDWKSPDGASEYVYHLVIESKHGSNHTSTYDKAIT---LQGLIPGTLYNITISPEVDH 612
+ + W+ P G + Y++ + K + IT + L+PG LY +T+S
Sbjct: 524 LKVKWQRPPGNVD-SYNITLSHKGTIKESRVLAPWITETHFKELVPGRLYQVTVSCVSGE 582
Query: 613 VWGDPNSTAQYTRPSNVSNIDVSTNTTAATL---------SWQNFDDASPTYSYCLLIEK 663
+ + + T P V+N++ + N +L W+ + S LL
Sbjct: 583 LSAQKMAVGR-TFPDKVANLEANNNGRMRSLVVSWSPPAGDWEQYRILLFNDSVVLLNIT 641
Query: 664 AGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQVGDGIKSLEPGRKSFCTDPASMA 723
G TQ V D T L+PG Y VE+ + G+ +K+ E R T P ++
Sbjct: 642 VGKEE--TQYVMD-------DTGLVPGRQYEVEVIVESGN-LKNSE--RCQGRTVPLAVL 689
Query: 724 SFDCEVVPKEPALVLKWTCPPGANAGFELEVSSGAWNNATHLESCSSENGTEYRTEVTYL 783
+ E +L + W P A +E + S A + + S++ E+ T L
Sbjct: 690 QLRVKHA-NETSLSIMWQTPV---AEWEKYIISLADRDLLLIHKSLSKDAKEF--TFTDL 743
Query: 784 NFSTSYNISITTVSCGKMAAPTRNTCTTGITDPPPPDGSPNITSVSHNSVKVKFSGFEAS 843
Y ++T++S +N ++ + P ++ + F+ + +
Sbjct: 744 VPGRKYMATVTSIS-----GDLKN--SSSVKGRTVPAQVTDLHVANQGMTSSLFTNWTQA 796
Query: 844 HGPIKAYAVIL----TTGEAGHPSADVLKYTYEDFKKGA 878
G ++ Y V+L + S++ +Y++ K G+
Sbjct: 797 QGDVEFYQVLLIHENVVIKNESISSETSRYSFHSLKSGS 835
Score = 37.4 bits (85), Expect = 0.097
Identities = 79/348 (22%), Positives = 141/348 (40%), Gaps = 51/348 (14%)
Query: 115 SSTGPSPVFDIKAVSISPTNVILTWKSNDTAASEYKYVVKHKMENEKTITVVHQPWCN-- 172
S T PSP + I+ T++ +TWK + ++ + T V P+ N
Sbjct: 1475 SRTAPSPPSLMSFADIANTSLAITWKGPPDWTDYNDFELQWLPRDALT---VFNPYNNRK 1531
Query: 173 -----ITGLRPATSYVFSITPGIGN--ETWGDPRVIKVITEPIPVSDLRVALTGVRKAAL 225
+ GLRP SY F++ G+ +T+ P V T+P + +L A
Sbjct: 1532 SEGRIVYGLRPGRSYQFNVKTVSGDSWKTYSKPIFGSVRTKPDKIQNLHCRPQNSTAIAC 1591
Query: 226 SW----SNGNG-TASCRVL-LESIGSHEELTQDSRLQVNISGLKPGVQYNINPYLLQSNK 279
SW S+ +G + CR + + + +L ++ L +NI L P +Y L S K
Sbjct: 1592 SWIPPDSDFDGYSIECRKMDTQEVEFSRKLEKEKSL-LNIMMLVPHKRY------LVSIK 1644
Query: 280 TKGDPLGTEGGLDASNTERSRAGSPTAPVHDESLVGPVDPSSGQQSRDTEV---LLVGLE 336
+ + +E D++ T R P P H V D + S + V
Sbjct: 1645 VQSAGMTSEVVEDSTITMIDR--PPPPPPHIR--VNEKDVLISKSSINFTVNCSWFSDTN 1700
Query: 337 PGTRYNATVYSQAANGTEGQPQA-------IEFRTNA-IQVFDVTAVNISATSLTLIWKV 388
+Y V +A E +P+ +E+R NA I+V+ N A+ K
Sbjct: 1701 GAVKYFTVVVREADGSDELKPEQQHPLPSYLEYRHNASIRVYQ---TNYFAS------KC 1751
Query: 389 SDNESSSNYTYKIHVAGETDS--SNLNVSEPRAVIPGLRSSTFYNITV 434
++N +S++ ++ I + E +S + ++ + L+ T Y I++
Sbjct: 1752 AENPNSNSKSFNIKLGAEMESLGGKCDPTQQKFCDGPLKPHTAYRISI 1799
>gi|157952213 protein tyrosine phosphatase, receptor type, B isoform b
precursor [Homo sapiens]
Length = 1997
Score = 428 bits (1101), Expect = e-119
Identities = 371/1290 (28%), Positives = 579/1290 (44%), Gaps = 154/1290 (11%)
Query: 137 LTWKSNDTAASEYKYVVKHKMENEKTITVVH-QPWCNITGLRPATSYVFSITPGIGN--- 192
++W Y+ +K+K +T ++ + C L P Y ++T G
Sbjct: 750 VSWVHATGDFDHYEVTIKNKNNFIQTKSIPKSENECVFVQLVPGRLYSVTVTTKSGQYEA 809
Query: 193 ETWGDPRVIKVITEPIPVSDLRVALTGVRKAALSWSNGNGTAS---CRVLLESIGSHEEL 249
G+ R I P PV DL + ++WS NG ++L +
Sbjct: 810 NEQGNGRTI-----PEPVKDLTLRNRSTEDLHVTWSGANGDVDQYEIQLLFNDMKVFPPF 864
Query: 250 -TQDSRLQVNISGLKPGVQYNINPYLLQSN--------------KTKGDPLGTEGGLDAS 294
++ + + L PG QY I + + K + G D+
Sbjct: 865 HLVNTATEYRFTSLTPGRQYKILVLTISGDVQQSAFIEGFTVPSAVKNIHISPNGATDSL 924
Query: 295 NTERSRAGSPTAPVHDESLVGPVDPSSGQQSRDT-----EVLLVGLEPGTRYNATVYSQA 349
+ G D V S S+ E LE G +Y + S
Sbjct: 925 TVNWTPGGGDV----DSYTVSAFRHSQKVDSQTIPKHVFEHTFHRLEAGEQYQIMIAS-- 978
Query: 350 ANGTEGQPQAIEFRTNAIQVFDVTAVNI-SATSLTLIWKVSDNESSSNYTYKIHVAGETD 408
+G+ + RT V V A N S+ SL + W+ + + Y I + E
Sbjct: 979 VSGSLKNQINVVGRTVPASVQGVIADNAYSSYSLIVSWQKAAGVAER---YDILLLTENG 1035
Query: 409 SSNLNVSEPRAV----IPGLRSSTFYNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTV 464
N SEP L Y I + V G + + T P V+D R+T
Sbjct: 1036 ILLRNTSEPATTKQHKFEDLTPGKKYKIQILTVSGGLFSKEAQTEGRTVPAAVTDLRITE 1095
Query: 465 VSTTEIGLAWSSHDAESFQMHI---TQEGAGNSRVEITTN-QSIIIGGLFPGTKYCFEIV 520
ST + W++ + E +I +G R ++ QS L G Y IV
Sbjct: 1096 NSTRHLSFRWTASEGELSWYNIFLYNPDGNLQERAQVDPLVQSFSFQNLLQGRMYKMVIV 1155
Query: 521 PKGPNGTEGASRTVCNRTVPSAVFDIHVVYVTTTE-MWLDWKSPDGASEYVYHLVIESKH 579
+G + RTVP++V + TT+ +W +W G ++ Y L++ + +
Sbjct: 1156 TH--SGELSNESFIFGRTVPASVSHLRGSNRNTTDSLWFNWSPASGDFDF-YELILYNPN 1212
Query: 580 GSNHTSTYDKAIT---LQGLIPG---TLYNITISPEVDHVWGDPNSTAQYTRPSNVSNID 633
G+ + DK +T QGL+PG L+ +T S ++ + + TA + PS +S D
Sbjct: 1213 GTKKENWKDKDLTEWRFQGLVPGRKYVLWVVTHSGDLSNKVTAESRTAP-SPPSLMSFAD 1271
Query: 634 VSTNTTAATLS----WQNFDDASPTY---SYCLLIEKAGNSSNATQVVTDIGITDATVTE 686
++ + A T W +++D + + N + ++V
Sbjct: 1272 IANTSLAITWKGPPDWTDYNDFELQWLPRDALTVFNPYNNRKSEGRIVYG---------- 1321
Query: 687 LIPGSSYTVEIFAQVGDGIKSL-EPGRKSFCTDPASMASFDCEVVPKEPALVLKWTCPPG 745
L PG SY + GD K+ +P S T P + + C A+ W P
Sbjct: 1322 LRPGRSYQFNVKTVSGDSWKTYSKPIFGSVRTKPDKIQNLHCRP-QNSTAIACSWIPPDS 1380
Query: 746 ANAGFELEVSSGAWNNATHLESCSSENGTEYRTEVTYLNFST-----SYNISITTVSCGK 800
G+ +E +++ E + E + LN Y +SI S G
Sbjct: 1381 DFDGYSIECRK--------MDTQEVEFSRKLEKEKSLLNIMMLVPHKRYLVSIKVQSAGM 1432
Query: 801 MAAPTRNTCTTGITDPPPPDGSPNITS----VSHNSVK--VKFSGFEASHGPIKAYAVIL 854
+ ++ T I PPPP + +S +S+ V S F ++G +K + V++
Sbjct: 1433 TSEVVEDSTITMIDRPPPPPPHIRVNEKDVLISKSSINFTVNCSWFSDTNGAVKYFTVVV 1492
Query: 855 TTGEAG--------HPSADVLKYTYEDFKKGASDTYVTYLIRTEEKGRSQSLSEVLKYEI 906
+ HP L+Y + + Y + + E S S S + I
Sbjct: 1493 READGSDELKPEQQHPLPSYLEYRHNASIRVYQTNY--FASKCAENPNSNSKS----FNI 1546
Query: 907 DVGNESTTLG---------YYNGKLEPLGSYRACVAGFTNITFHPQNKGLIDGAESYVSF 957
+G E +LG + +G L+P +YR + FT + ++ L + + S
Sbjct: 1547 KLGAEMESLGGKCDPTQQKFCDGPLKPHTAYRISIRAFTQLF----DEDLKEFTKPLYSD 1602
Query: 958 SRYSDAVSLPQDPGVICGAVFGCIFGALVI---VTVGGFIFWRKK---RKDAKNNEVSFS 1011
+ +S ++ +P + GA+ G G +I V V + R+K ++ + +S
Sbjct: 1603 TFFSLPITTESEP--LFGAIEGVSAGLFLIGMLVAVVALLICRQKVSHGRERPSARLSIR 1660
Query: 1012 QIKP-------------KKSKLIRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQPKY 1058
+ +P K S I++ FE +F K QADSN ++EYE+LK VG +Q
Sbjct: 1661 RDRPLSVHLNLGQKGNRKTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCD 1720
Query: 1059 AAELAENRGKNRYNNVLPYDISRVKLS-VQTHSTDDYINANYMPGYHSKKDFIATQGPLP 1117
A L ENRGKNRYNN+LPYD +RVKLS V DYINA+Y+PG + ++++I TQGPLP
Sbjct: 1721 IALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLP 1780
Query: 1118 NTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQ-AQDYGDITVAMTSEIVLPE 1176
T DFW+MVWE+NV+ I+M+T+CVE+GR KC+ YWP+ Q + YGD+ + M SE VLPE
Sbjct: 1781 GTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPE 1840
Query: 1177 WTIRDFTVKNIQTSESHPL-RQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPI 1235
WTIR+F + + ++H L R FH+T WPDHGVP+TT LI F VRDY+ +SP P
Sbjct: 1841 WTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPT 1900
Query: 1236 LVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCV 1295
+VHCSAGVGRTGTFIA+DR++ Q++++++VD+YG V+DLR+HR MVQTE QYV+L+QCV
Sbjct: 1901 VVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCV 1960
Query: 1296 LDIVRSQKDSKVDLIYQNTTAMTIYENLAP 1325
D++R++K Q IYEN+ P
Sbjct: 1961 RDVLRARKLRS----EQENPLFPIYENVNP 1986
Score = 62.8 bits (151), Expect = 2e-09
Identities = 136/647 (21%), Positives = 247/647 (38%), Gaps = 109/647 (16%)
Query: 171 CNITGLRPATSYVFSITPGIGNETWGDPRVIKVITEPIPVSDLRVALTGVRKAALS--WS 228
CN+ L+ T Y F I + + R + + T+P+P + V+ +L W+
Sbjct: 80 CNLQDLQAGTIYNFRII------SLDEERTVVLQTDPLPPARFGVSKEKTTSTSLHVWWT 133
Query: 229 NGNGTASCRVLLESIGSHEELTQDSRLQVNIS-------GLKPGVQYNINPYLLQSNK-- 279
+G + + + + + Q ++Q + S L G +YNI + K
Sbjct: 134 PSSGKVTSYEV-QLFDENNQKIQGVQIQESTSWNEYTFFNLTAGSKYNIAITAVSGGKRS 192
Query: 280 --------------------TKGDPLGTEGGLDASNTERSRAGSPTAPVHDESLV---GP 316
TK + L + N ER R + D+ ++ G
Sbjct: 193 FSVYTNGSTVPSPVKDIGISTKANSLLISWSHGSGNVERYRL-----MLMDKGILVHGGV 247
Query: 317 VDPSSGQQSRDTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQVFDVTAVN 376
VD + T GL PG YN TV ++AA + + + RT ++V ++ N
Sbjct: 248 VDKHA------TSYAFHGLTPGYLYNLTVMTEAAGLQNYRWKLV--RTAPMEVSNLKVTN 299
Query: 377 I-SATSLTLIWKVSDNESSSNYTYKIHVAGETDSSNLNVS------EPRAVIPGLRSSTF 429
S TSL + W+ G DS N+ +S E R + P + + F
Sbjct: 300 DGSLTSLKVKWQ--------------RPPGNVDSYNITLSHKGTIKESRVLAPWITETHF 345
Query: 430 --------YNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTE-IGLAWS--SHD 478
Y +TV V G++ + T P V++ + ++WS + D
Sbjct: 346 KELVPGRLYQVTVSCVSGELSAQKMAVG-RTFPDKVANLEANNNGRMRSLVVSWSPPAGD 404
Query: 479 AESFQMHITQEGAGNSRVEITTNQSIII---GGLFPGTKYCFEIVPKGPNGTEGASRTVC 535
E +++ + + + + ++ + GL PG +Y E++ + +G S
Sbjct: 405 WEQYRILLFNDSVVLLNITVGKEETQYVMDDTGLVPGRQYEVEVIVE--SGNLKNSERCQ 462
Query: 536 NRTVPSAVFDIHVVYVTTTEMWLDWKSPDGASE-YVYHLVIESKHGSNHTSTYD-KAITL 593
RTVP AV + V + T + + W++P E Y+ L + + + D K T
Sbjct: 463 GRTVPLAVLQLRVKHANETSLSIMWQTPVAEWEKYIISLADRDLLLIHKSLSKDAKEFTF 522
Query: 594 QGLIPGTLYNITISPEVDHVWGDPNSTAQYTRPSNVSNIDVSTN--TTAATLSWQNFDDA 651
L+PG Y T++ + + +S T P+ V+++ V+ T++ +W
Sbjct: 523 TDLVPGRKYMATVT-SISGDLKNSSSVKGRTVPAQVTDLHVANQGMTSSLFTNWTQAQGD 581
Query: 652 SPTYSYCLLIEKAGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQVGDGIKSLE-- 709
Y L+ E + + T + + L GS Y+V + V GI S +
Sbjct: 582 VEFYQVLLIHENVVIKNESISSET----SRYSFHSLKSGSLYSV-VVTTVSGGISSRQVV 636
Query: 710 -PGRKSFCTDPASMASFDCEVVPKEPALVLKWTCPPGANAGFELEVS 755
GR T P+S++ + L + W PG +E+ +S
Sbjct: 637 VEGR----TVPSSVSGVTVNNSGRNDYLSVSWLLAPGDVDNYEVTLS 679
Score = 59.7 bits (143), Expect = 2e-08
Identities = 143/685 (20%), Positives = 262/685 (38%), Gaps = 81/685 (11%)
Query: 110 SQKTPSSTGPSPVFDIKAVSISPTNVILTWKSNDTAASEYKYVVKHKMENEKTITVVHQP 169
S++ T P V ++ + T++ + W++ A KY++ ++ + ++H+
Sbjct: 458 SERCQGRTVPLAVLQLRVKHANETSLSIMWQT--PVAEWEKYIISLA---DRDLLLIHKS 512
Query: 170 WCN------ITGLRPATSYVFSITPGIGNETWGDPRVIKVITEPIPVSDLRVALTGVRKA 223
T L P Y+ ++T G+ + +K T P V+DL VA G+ +
Sbjct: 513 LSKDAKEFTFTDLVPGRKYMATVTSISGDLK--NSSSVKGRTVPAQVTDLHVANQGMTSS 570
Query: 224 ALS-WSNGNGTASC-RVLL--ESIGSHEELTQDSRLQVNISGLKPGVQYNINPYLLQSNK 279
+ W+ G +VLL E++ E + + LK G Y++ +
Sbjct: 571 LFTNWTQAQGDVEFYQVLLIHENVVIKNESISSETSRYSFHSLKSGSLYSVVVTTVSGGI 630
Query: 280 TKGDPL-------GTEGGLDASNTERSRAGSPT---APVHDESLVGPVDPSSGQQSRDTE 329
+ + + G+ +N+ R+ S + AP G VD S D +
Sbjct: 631 SSRQVVVEGRTVPSSVSGVTVNNSGRNDYLSVSWLLAP-------GDVDNYEVTLSHDGK 683
Query: 330 VL-------------LVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQVFDVTAVN 376
V+ L PG Y T+ +++ G+ + F V V+
Sbjct: 684 VVQSLVIAKSVRECSFSSLTPGRLYTVTITTRS-----GKYENHSFSQERTVPDKVQGVS 738
Query: 377 ISATSLTLIWKVSDNESSSNYT-YKIHVAGETD---SSNLNVSEPRAVIPGLRSSTFYNI 432
+S ++ + +VS ++ ++ Y++ + + + + ++ SE V L Y++
Sbjct: 739 VSNSARSDYLRVSWVHATGDFDHYEVTIKNKNNFIQTKSIPKSENECVFVQLVPGRLYSV 798
Query: 433 TVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDAESFQMHITQEGAG 492
TV G E T P PV D + ST ++ + WS + + Q I Q
Sbjct: 799 TVTTKSGQYEANEQG-NGRTIPEPVKDLTLRNRSTEDLHVTWSGANGDVDQYEI-QLLFN 856
Query: 493 NSRV-----EITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTVPSAVFDIH 547
+ +V + T L PG +Y +I+ +G S + TVPSAV +IH
Sbjct: 857 DMKVFPPFHLVNTATEYRFTSLTPGRQY--KILVLTISGDVQQSAFIEGFTVPSAVKNIH 914
Query: 548 V-VYVTTTEMWLDWKSPDGASEYVYHLVIESKHGSNHTSTYDKAI---TLQGLIPGTLYN 603
+ T + ++W +P G Y + + T K + T L G Y
Sbjct: 915 ISPNGATDSLTVNW-TPGGGDVDSYTVSAFRHSQKVDSQTIPKHVFEHTFHRLEAGEQYQ 973
Query: 604 ITISPEVDHVWGDPNSTAQYTRPSNVSNI--DVSTNTTAATLSWQNFDDASPTYSYCLLI 661
I I+ + N + T P++V + D + ++ + +SWQ + Y LL
Sbjct: 974 IMIASVSGSLKNQINVVGR-TVPASVQGVIADNAYSSYSLIVSWQKAAGVAERYDILLLT 1032
Query: 662 EKAGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQVGDGIKSLEPGRKSFCTDPAS 721
E N ++ T +L PG Y ++I V G+ S E + T PA+
Sbjct: 1033 ENGILLRNTSEPAT---TKQHKFEDLTPGKKYKIQILT-VSGGLFSKE-AQTEGRTVPAA 1087
Query: 722 MASFDCEVVPKEPA-LVLKWTCPPG 745
+ D + L +WT G
Sbjct: 1088 VT--DLRITENSTRHLSFRWTASEG 1110
Score = 58.2 bits (139), Expect = 5e-08
Identities = 120/579 (20%), Positives = 228/579 (39%), Gaps = 75/579 (12%)
Query: 332 LVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQV--FDVTAVNISATSLTLIWKVS 389
L L+ GT YN + S + + + +T+ + F V+ ++TSL + W S
Sbjct: 82 LQDLQAGTIYNFRIISL------DEERTVVLQTDPLPPARFGVSKEKTTSTSLHVWWTPS 135
Query: 390 DNESSSNYTYKIHVAGETDSS--NLNVSEPRA----VIPGLRSSTFYNITVCPVLGDIEG 443
+ +S Y++ + E + + + E + L + + YNI + V G
Sbjct: 136 SGKVTS---YEVQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGSKYNIAITAVSGGKRS 192
Query: 444 TPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWS--SHDAESFQMHITQEG-AGNSRVEITT 500
+ T P PV D ++ + + + ++WS S + E +++ + +G + V
Sbjct: 193 FSVYTNGSTVPSPVKDIGISTKANSLL-ISWSHGSGNVERYRLMLMDKGILVHGGVVDKH 251
Query: 501 NQSIIIGGLFPGTKYCFEIVPKGPNGTEGAS----RTVCNRTVPSAVFDIHVVY-VTTTE 555
S GL PG Y ++ TE A R RT P V ++ V + T
Sbjct: 252 ATSYAFHGLTPGYLYNLTVM------TEAAGLQNYRWKLVRTAPMEVSNLKVTNDGSLTS 305
Query: 556 MWLDWKSPDGASEYVYHLVIESKHGSNHTSTYDKAIT---LQGLIPGTLYNITISPEVDH 612
+ + W+ P G + Y++ + K + IT + L+PG LY +T+S
Sbjct: 306 LKVKWQRPPGNVD-SYNITLSHKGTIKESRVLAPWITETHFKELVPGRLYQVTVSCVSGE 364
Query: 613 VWGDPNSTAQYTRPSNVSNIDVSTNTTAATL---------SWQNFDDASPTYSYCLLIEK 663
+ + + T P V+N++ + N +L W+ + S LL
Sbjct: 365 LSAQKMAVGR-TFPDKVANLEANNNGRMRSLVVSWSPPAGDWEQYRILLFNDSVVLLNIT 423
Query: 664 AGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQVGDGIKSLEPGRKSFCTDPASMA 723
G TQ V D T L+PG Y VE+ + G+ +K+ E R T P ++
Sbjct: 424 VGKEE--TQYVMD-------DTGLVPGRQYEVEVIVESGN-LKNSE--RCQGRTVPLAVL 471
Query: 724 SFDCEVVPKEPALVLKWTCPPGANAGFELEVSSGAWNNATHLESCSSENGTEYRTEVTYL 783
+ E +L + W P A +E + S A + + S++ E+ T L
Sbjct: 472 QLRVKHA-NETSLSIMWQTPV---AEWEKYIISLADRDLLLIHKSLSKDAKEF--TFTDL 525
Query: 784 NFSTSYNISITTVSCGKMAAPTRNTCTTGITDPPPPDGSPNITSVSHNSVKVKFSGFEAS 843
Y ++T++S +N ++ + P ++ + F+ + +
Sbjct: 526 VPGRKYMATVTSIS-----GDLKN--SSSVKGRTVPAQVTDLHVANQGMTSSLFTNWTQA 578
Query: 844 HGPIKAYAVIL----TTGEAGHPSADVLKYTYEDFKKGA 878
G ++ Y V+L + S++ +Y++ K G+
Sbjct: 579 QGDVEFYQVLLIHENVVIKNESISSETSRYSFHSLKSGS 617
Score = 37.4 bits (85), Expect = 0.097
Identities = 79/348 (22%), Positives = 141/348 (40%), Gaps = 51/348 (14%)
Query: 115 SSTGPSPVFDIKAVSISPTNVILTWKSNDTAASEYKYVVKHKMENEKTITVVHQPWCN-- 172
S T PSP + I+ T++ +TWK + ++ + T V P+ N
Sbjct: 1257 SRTAPSPPSLMSFADIANTSLAITWKGPPDWTDYNDFELQWLPRDALT---VFNPYNNRK 1313
Query: 173 -----ITGLRPATSYVFSITPGIGN--ETWGDPRVIKVITEPIPVSDLRVALTGVRKAAL 225
+ GLRP SY F++ G+ +T+ P V T+P + +L A
Sbjct: 1314 SEGRIVYGLRPGRSYQFNVKTVSGDSWKTYSKPIFGSVRTKPDKIQNLHCRPQNSTAIAC 1373
Query: 226 SW----SNGNG-TASCRVL-LESIGSHEELTQDSRLQVNISGLKPGVQYNINPYLLQSNK 279
SW S+ +G + CR + + + +L ++ L +NI L P +Y L S K
Sbjct: 1374 SWIPPDSDFDGYSIECRKMDTQEVEFSRKLEKEKSL-LNIMMLVPHKRY------LVSIK 1426
Query: 280 TKGDPLGTEGGLDASNTERSRAGSPTAPVHDESLVGPVDPSSGQQSRDTEV---LLVGLE 336
+ + +E D++ T R P P H V D + S + V
Sbjct: 1427 VQSAGMTSEVVEDSTITMIDR--PPPPPPHIR--VNEKDVLISKSSINFTVNCSWFSDTN 1482
Query: 337 PGTRYNATVYSQAANGTEGQPQA-------IEFRTNA-IQVFDVTAVNISATSLTLIWKV 388
+Y V +A E +P+ +E+R NA I+V+ N A+ K
Sbjct: 1483 GAVKYFTVVVREADGSDELKPEQQHPLPSYLEYRHNASIRVYQ---TNYFAS------KC 1533
Query: 389 SDNESSSNYTYKIHVAGETDS--SNLNVSEPRAVIPGLRSSTFYNITV 434
++N +S++ ++ I + E +S + ++ + L+ T Y I++
Sbjct: 1534 AENPNSNSKSFNIKLGAEMESLGGKCDPTQQKFCDGPLKPHTAYRISI 1581
>gi|241896924 protein tyrosine phosphatase, receptor type, H isoform 1
precursor [Homo sapiens]
Length = 1115
Score = 387 bits (994), Expect = e-107
Identities = 305/1060 (28%), Positives = 474/1060 (44%), Gaps = 94/1060 (8%)
Query: 328 TEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQVFDVTAVNISA---TSLTL 384
T V + GL PG+ Y +V+ + +G ++ T A V + + A +S+ L
Sbjct: 82 TNVTVDGLGPGSLYTCSVWVEK----DGVNSSVGTVTTATAPNPVRNLRVEAQTNSSIAL 137
Query: 385 IWKVSDNESSSNYTYKIHVAGETDSSNL-NVSEPRAVIPGLRSSTFYNITVCPVLGDIEG 443
W+V D N TY + G+ + + + + GL Y ++ I
Sbjct: 138 TWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDGLEPGCLYAFSMWVGKNGINS 197
Query: 444 TPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDA-----ESFQMHITQEGAGNSRVEI 498
+ T PV + RV +T+ I L+W D ++ + T +G G +
Sbjct: 198 SRETRNATTAHNPVRNLRVEAQTTSSISLSWEVPDGTDPQNSTYCVQCTGDG-GRTETRN 256
Query: 499 TTNQSIIIGGLFPGTKY-CFEIVPKGPNGTEGASRTVCNRTVPSAVFDIHVVYVTTTEMW 557
TT+ + + GL PG+ Y C V K +G + V + T P+ V ++ V T + +
Sbjct: 257 TTDTRVTVDGLGPGSLYTCSVWVEK--DGVNSSVEIVTSATAPNPVRNLTVEAQTNSSIA 314
Query: 558 LDWKSPDGASEYVYHLVIESKHGSNHTSTYDKA---ITLQGLIPGTLYNITISPEVDHVW 614
L W+ PDG +E T A IT+ L PG LY ++ + +
Sbjct: 315 LTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDRLEPGCLYVFSVWVGKNGIN 374
Query: 615 GDPNSTAQYTRPSNVSNIDVSTNTTAA-TLSWQNFDDASPTYSYCLLIEKAGNSSNA-TQ 672
+ T P+ V N+ + T T ++ L W+ D P Y +E G+ T+
Sbjct: 375 SSRETRNATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQ-DYTYWVEYTGDGGGTETR 433
Query: 673 VVTDIGITDATVTELIPGSSYTVEIFAQVGDGIKSLEPGRKSFCTDPASMASFDCEVVPK 732
T+ T T L PG+ YT ++A+ S + S T P ++ S +
Sbjct: 434 NTTN---TSVTAERLEPGTLYTFSVWAEKNGARGSRQ--NVSISTVPNAVTSLSKQDWTN 488
Query: 733 EPALVLKWTCPPGANAGFELEVSSGAWNNATHLESCSSENGTEYRTEVTY--LNFSTSYN 790
+ L+WT P G + S W + + T++T L + Y+
Sbjct: 489 S-TIALRWTAPQGPG-----QSSYSYWVSWVREGMTDPRTQSTSGTDITLKELEAGSLYH 542
Query: 791 ISITTVSCGKMAAPTRNTCTTGITDPPPPDGSPNITSVSHNSVKVKFSGFEASHGPIKAY 850
+ TV + N+ T T P N T NSV + + H + Y
Sbjct: 543 L---TVWAERNEVRGYNSTLTAATAPNEVTDLQNETQTK-NSVMLWWKAPGDPHSQLYVY 598
Query: 851 AVILTTGEAGHPS---------------ADVLKYTYEDFKKGASDTYVTYLIRTEEKGRS 895
V GHP + Y E + G + + R + +
Sbjct: 599 WV--QWASKGHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWAERNDVASST 656
Query: 896 QSL-SEVLKYEIDVGNESTTLGYYNGKLE---PLGSYRA--------------------- 930
QSL + + + + +T Y L P G Y A
Sbjct: 657 QSLCASTYPDTVTITSCVSTSAGYGVNLIWSCPQGGYEAFELEVGGQRGSQDRSSCGEAV 716
Query: 931 CVAGFTNITFHPQNKGLIDGAESYVSFSRYSDAVSLPQDPGVICGAVFGCIFGALVIVTV 990
V G +P I VS S V + GVI GA G + L ++ V
Sbjct: 717 SVLGLGPARSYPATITTIWDGMKVVSHS----VVCHTESAGVIAGAFVGIL---LFLILV 769
Query: 991 GGFIFWRKKRKDAKNNEVSFSQIKPKKSKLIRVENFEAYFKKQQADSNCGFAEEYEDLKL 1050
G IF+ K+R K + + I E+F + +K + DSNCGFA++Y+ L L
Sbjct: 770 GLLIFFLKRRNKKKQQKPELRDLVFSSPGDIPAEDFADHVRKNERDSNCGFADKYQQLSL 829
Query: 1051 VGISQPKYAAELAENRGKNRYNNVLPYDISRVKLS-VQTHSTDDYINANYMPGYHSKKDF 1109
VG SQ + A +EN KNRY NVLPYD SRV L + DYINA++MPG S ++F
Sbjct: 830 VGHSQSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEF 889
Query: 1110 IATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWP-SKQAQDYGDITVAM 1168
IATQGPLP T+ DFWR+VWE+ + ++MLT C+E GR KCE YWP Q +G + V +
Sbjct: 890 IATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTL 949
Query: 1169 TSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQ 1228
E V+ WT+R+ + ++ ++ +RQFH+ +WPDHGVP + D L+ F ++R ++ Q
Sbjct: 950 VGEEVMENWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQ 1009
Query: 1229 SPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQY 1288
+ P +VHCSAGVGRTGT IA+D L+ Q+++E + + V +R RPLMVQTE QY
Sbjct: 1010 TMEGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQY 1069
Query: 1289 VFLNQCVLDIVR--SQKDSKVDLIYQNTTAMTIYENLAPV 1326
VFL+QC+L ++ +Q ++ ++ Y++ + IYEN+A +
Sbjct: 1070 VFLHQCILRFLQQSAQAPAEKEVPYEDVENL-IYENVAAI 1108
Score = 139 bits (349), Expect = 2e-32
Identities = 172/742 (23%), Positives = 285/742 (38%), Gaps = 71/742 (9%)
Query: 119 PSPVFDIKAVSISPTNVILTWKSNDTAASEYKYVVKHKMENEKTITVVHQPWCNIT--GL 176
P+P ++ + + +++ L+W+ D S+ + T + N+T GL
Sbjct: 30 PNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTTATNVTVDGL 89
Query: 177 RPATSYVFSI---TPGIGNETWGDPRVIKVITEPIPVSDLRVALTGVRKAALSWSNGNG- 232
P + Y S+ G+ + + T P PV +LRV AL+W +G
Sbjct: 90 GPGSLYTCSVWVEKDGVNSSVG----TVTTATAPNPVRNLRVEAQTNSSIALTWEVPDGP 145
Query: 233 ---TASCRVLLESIGSHEELTQDSRLQVNISGLKPGVQYNINPYL----------LQSNK 279
++ V G + + + GL+PG Y + ++ ++
Sbjct: 146 DPQNSTYGVEYTGDGGRAGTRSTAHTNITVDGLEPGCLYAFSMWVGKNGINSSRETRNAT 205
Query: 280 TKGDP---LGTEGGLDASNTERSRAGSPTAPVHDESLV---GPVDPSSGQQSRDTEVLLV 333
T +P L E +S + T P + V G + + + DT V +
Sbjct: 206 TAHNPVRNLRVEAQTTSSISLSWEVPDGTDPQNSTYCVQCTGDGGRTETRNTTDTRVTVD 265
Query: 334 GLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQVFDVTAVNISA---TSLTLIWKVSD 390
GL PG+ Y +V+ + +G ++E T+A V + + A +S+ L W+V D
Sbjct: 266 GLGPGSLYTCSVWVEK----DGVNSSVEIVTSATAPNPVRNLTVEAQTNSSIALTWEVPD 321
Query: 391 NESSSNYTYKIHVAGETDSSNL-NVSEPRAVIPGLRSSTFYNITVCPVLGDIEGTPGFLQ 449
N TY + G+ + + + + L Y +V I +
Sbjct: 322 GPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDRLEPGCLYVFSVWVGKNGINSSRETRN 381
Query: 450 VHTPPVPVSDFRVTVVSTTEIGLAWSSHDAE-----SFQMHITQEGAGNSRVEITTNQSI 504
T P PV + + + + I L W D ++ + T +G G + TTN S+
Sbjct: 382 ATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGG-TETRNTTNTSV 440
Query: 505 IIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTVPSAVFDIHVVYVTTTEMWLDWKSPD 564
L PGT Y F + + NG G+ + V TVP+AV + T + + L W +P
Sbjct: 441 TAERLEPGTLYTFSVWAE-KNGARGSRQNVSISTVPNAVTSLSKQDWTNSTIALRWTAPQ 499
Query: 565 GA--SEYVYHL--VIESKHGSNHTSTYDKAITLQGLIPGTLYNITISPEVDHVWGDPNST 620
G S Y Y + V E ST ITL+ L G+LY++T+ E + V G ++
Sbjct: 500 GPGQSSYSYWVSWVREGMTDPRTQSTSGTDITLKELEAGSLYHLTVWAERNEVRGYNSTL 559
Query: 621 AQYTRPSNVSNIDVSTNTTAATLSWQNF--DDASPTYSYCLLIEKAGN-------SSNAT 671
T P+ V+++ T T + + W D S Y Y + G+ +N
Sbjct: 560 TAATAPNEVTDLQNETQTKNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQANWV 619
Query: 672 QVVTDIGITDATVTELIPGSSYTVEIFAQVGDGIKSLEPGRKSFC--TDPASMASFDCEV 729
+ T V L PG+ Y ++A+ D S + S C T P ++ C
Sbjct: 620 NQTSRTNETWYKVEALEPGTLYNFTVWAERNDVASSTQ----SLCASTYPDTVTITSCVS 675
Query: 730 VPKEPALVLKWTCPPGANAGFELEVSSGAWNNATHLESCSSENGTEYRTEVTYLNFSTSY 789
+ L W+CP G FELEV G + SC V L + SY
Sbjct: 676 TSAGYGVNLIWSCPQGGYEAFELEV--GGQRGSQDRSSCGE------AVSVLGLGPARSY 727
Query: 790 NISITTVSCGKMAAPTRNTCTT 811
+ITT+ G C T
Sbjct: 728 PATITTIWDGMKVVSHSVVCHT 749
Score = 104 bits (259), Expect = 6e-22
Identities = 143/623 (22%), Positives = 241/623 (38%), Gaps = 66/623 (10%)
Query: 53 TGENGITQISSTAESFHKQNGTGTPQVETNTSEDGESSGANDSLRTPEQGSNGTDGASQK 112
TG+ G T+ +T + +G G + T S E G N S+ T
Sbjct: 68 TGDGGTTETRNTTATNVTVDGLGPGSLYT-CSVWVEKDGVNSSVGT-------------- 112
Query: 113 TPSSTGPSPVFDIKAVSISPTNVILTWKSNDTAASEYK-YVVKHKMENEK--TITVVHQP 169
++T P+PV +++ + + +++ LTW+ D + Y V++ + + T + H
Sbjct: 113 VTTATAPNPVRNLRVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAH-- 170
Query: 170 WCNIT--GLRPATSYVFSITPGIGNETWGDPRVIKVITEPIPVSDLRVALTGVRKAALSW 227
NIT GL P Y FS+ G N T PV +LRV +LSW
Sbjct: 171 -TNITVDGLEPGCLYAFSMWVG-KNGINSSRETRNATTAHNPVRNLRVEAQTTSSISLSW 228
Query: 228 SNGNGT----ASCRVLLESIGSHEELTQDSRLQVNISGLKPGVQYNINPYL--------- 274
+GT ++ V G E + +V + GL PG Y + ++
Sbjct: 229 EVPDGTDPQNSTYCVQCTGDGGRTETRNTTDTRVTVDGLGPGSLYTCSVWVEKDGVNSSV 288
Query: 275 -LQSNKTKGDP---LGTEGGLDAS---NTERSRAGSPTAPVHDESLVGPVDPSSGQQSRD 327
+ ++ T +P L E ++S E P + G + + +
Sbjct: 289 EIVTSATAPNPVRNLTVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAH 348
Query: 328 TEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQVFDVTAVNISATSLTLIWK 387
T + + LEPG Y +V+ NG + T V ++ + +S+ L W+
Sbjct: 349 TNITVDRLEPGCLYVFSVW-VGKNGINSSRETRNATTAPNPVRNLHMETQTNSSIALCWE 407
Query: 388 VSDNESSSNYTYKIHVAGETDSSNL-NVSEPRAVIPGLRSSTFYNITVCPVLGDIEGTPG 446
V D +YTY + G+ + N + L T Y +V G+
Sbjct: 408 VPDGPYPQDYTYWVEYTGDGGGTETRNTTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQ 467
Query: 447 FLQVHTPPVPVSDFRVTVVSTTEIGLAWSS-----HDAESFQMHITQEGAGNSRVEITTN 501
+ + T P V+ + + I L W++ + S+ + +EG + R + T+
Sbjct: 468 NVSISTVPNAVTSLSKQDWTNSTIALRWTAPQGPGQSSYSYWVSWVREGMTDPRTQSTSG 527
Query: 502 QSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTVPSAVFDIHVVYVTTTEMWLDWK 561
I + L G+ Y + + N G + T+ T P+ V D+ T + L WK
Sbjct: 528 TDITLKELEAGSLYHLTVWAE-RNEVRGYNSTLTAATAPNEVTDLQNETQTKNSVMLWWK 586
Query: 562 SP-DGASE-YVYHLVIESK-----------HGSNHTS-TYDKAITLQGLIPGTLYNITIS 607
+P D S+ YVY + SK + N TS T + ++ L PGTLYN T+
Sbjct: 587 APGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVW 646
Query: 608 PEVDHVWGDPNSTAQYTRPSNVS 630
E + V S T P V+
Sbjct: 647 AERNDVASSTQSLCASTYPDTVT 669
Score = 64.7 bits (156), Expect = 6e-10
Identities = 118/519 (22%), Positives = 193/519 (37%), Gaps = 74/519 (14%)
Query: 45 DPSVATVA---TGENGITQISSTAESFHKQNGTGTPQVETNTSEDGESSGANDSLRTPEQ 101
DP +T TG+ G T+ +T ++ +G G + T S E G N S+
Sbjct: 235 DPQNSTYCVQCTGDGGRTETRNTTDTRVTVDGLGPGSLYT-CSVWVEKDGVNSSVEI--- 290
Query: 102 GSNGTDGASQKTPSSTGPSPVFDIKAVSISPTNVILTWKSNDTAASEYK-YVVKHKMENE 160
S+T P+PV ++ + + +++ LTW+ D + Y V++ +
Sbjct: 291 -----------VTSATAPNPVRNLTVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDGG 339
Query: 161 K--TITVVHQPWCNIT--GLRPATSYVFSITPGIGNETWGDPRVIKVITEPIPVSDLRVA 216
+ T + H NIT L P YVFS+ G N T P PV +L +
Sbjct: 340 RAGTRSTAH---TNITVDRLEPGCLYVFSVWVG-KNGINSSRETRNATTAPNPVRNLHME 395
Query: 217 LTGVRKAALSWSNGNG----TASCRVLLESIGSHEELTQDSRLQVNISGLKPGVQYNINP 272
AL W +G + V G E + V L+PG Y +
Sbjct: 396 TQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGGTETRNTTNTSVTAERLEPGTLYTFSV 455
Query: 273 YLLQSNKTKGD----PLGTEGGLDAS--------NTERSRAGSPTAPVHDESLV------ 314
+ + N +G + T S +T R +P P
Sbjct: 456 W-AEKNGARGSRQNVSISTVPNAVTSLSKQDWTNSTIALRWTAPQGPGQSSYSYWVSWVR 514
Query: 315 -GPVDPSSGQQSRDTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQVFDVT 373
G DP + Q + T++ L LE G+ Y+ TV+++ N G + T +V D+
Sbjct: 515 EGMTDPRT-QSTSGTDITLKELEAGSLYHLTVWAE-RNEVRGYNSTLTAATAPNEVTDLQ 572
Query: 374 AVNISATSLTLIWKVSDNESSSNYTYKIHVA-------GETDSSN-----LNVSEPRAVI 421
+ S+ L WK + S Y Y + A G+ +N +E +
Sbjct: 573 NETQTKNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTNETWYKV 632
Query: 422 PGLRSSTFYNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTE---IGLAWSSHD 478
L T YN TV D+ + L T P V+ + VST+ + L WS
Sbjct: 633 EALEPGTLYNFTVWAERNDVASSTQSLCASTYPDTVT--ITSCVSTSAGYGVNLIWSCPQ 690
Query: 479 A--ESFQMHITQEGAGNSRVEITTNQSIIIGGLFPGTKY 515
E+F++ + G S+ + +++ + GL P Y
Sbjct: 691 GGYEAFELEV--GGQRGSQDRSSCGEAVSVLGLGPARSY 727
Score = 57.4 bits (137), Expect = 9e-08
Identities = 71/327 (21%), Positives = 121/327 (37%), Gaps = 35/327 (10%)
Query: 531 SRTVCNRTVPSAVFDIHVVYVTTTEMWLDWKSPDGASEYVYHLVIESKHGSNHTSTYDKA 590
S T P+ ++ V TT+ + L W+ PDG + ++ T T +
Sbjct: 21 SWTGARAPAPNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTT 80
Query: 591 ---ITLQGLIPGTLYNITISPEVDHVWGDPNSTAQYTRPSNVSNIDVSTNTTAA-TLSWQ 646
+T+ GL PG+LY ++ E D V + T P+ V N+ V T ++ L+W+
Sbjct: 81 ATNVTVDGLGPGSLYTCSVWVEKDGVNSSVGTVTTATAPNPVRNLRVEAQTNSSIALTWE 140
Query: 647 NFDDASPTYSYCLLIEKAGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQVGDGIK 706
D P S +E G+ A T T+ TV L PG Y ++
Sbjct: 141 VPDGPDPQNS-TYGVEYTGDGGRAGTRST--AHTNITVDGLEPGCLYAFSMWVGKNGINS 197
Query: 707 SLEPGRKSFCTDPASMASFDCEVVPKEPALVLKWTCPPGANAGFELEVSSGAWNNATHLE 766
S E + +P + + ++ L W P G + N+T+
Sbjct: 198 SRETRNATTAHNPVRNLRVEAQTT---SSISLSWEVPDGTDP-----------QNSTYCV 243
Query: 767 SCSSENG-------TEYRTEVTYLNFSTSYNISITTVSCGKMAAPTRNTCTTGITDPPPP 819
C+ + G T+ R V L + Y S+ G N+ +T P
Sbjct: 244 QCTGDGGRTETRNTTDTRVTVDGLGPGSLYTCSVWVEKDGV------NSSVEIVTSATAP 297
Query: 820 DGSPNITSVSHNSVKVKFSGFEASHGP 846
+ N+T + + + + +E GP
Sbjct: 298 NPVRNLTVEAQTNSSIALT-WEVPDGP 323
>gi|241896926 protein tyrosine phosphatase, receptor type, H isoform 2
precursor [Homo sapiens]
Length = 937
Score = 362 bits (929), Expect = 1e-99
Identities = 278/930 (29%), Positives = 424/930 (45%), Gaps = 86/930 (9%)
Query: 454 PVPVSDFRVTVVSTTEIGLAWSSHDA-----ESFQMHITQEGAGNSRVEITTNQSIIIGG 508
P P + V +T+ I L+W D ++ + T +G G + TT ++ + G
Sbjct: 30 PNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDG-GTTETRNTTATNVTVDG 88
Query: 509 LFPGTKY-CFEIVPKGPNGTEGASRTVCNRTVPSAVFDIHVVYVTTTEMWLDWKSPDGAS 567
L PG+ Y C V K +G + TV T P+ V ++ V T + + L W+ PDG
Sbjct: 89 LGPGSLYTCSVWVEK--DGVNSSVGTVTTATAPNPVRNLTVEAQTNSSIALTWEVPDGPD 146
Query: 568 EYVYHLVIESKHGSNHTSTYDKA---ITLQGLIPGTLYNITISPEVDHVWGDPNSTAQYT 624
+E T A IT+ L PG LY ++ + + + T
Sbjct: 147 PQNSTYGVEYTGDGGRAGTRSTAHTNITVDRLEPGCLYVFSVWVGKNGINSSRETRNATT 206
Query: 625 RPSNVSNIDVSTNTTAA-TLSWQNFDDASPTYSYCLLIEKAGNSSNA-TQVVTDIGITDA 682
P+ V N+ + T T ++ L W+ D P Y +E G+ T+ T+ T
Sbjct: 207 APNPVRNLHMETQTNSSIALCWEVPDGPYPQ-DYTYWVEYTGDGGGTETRNTTN---TSV 262
Query: 683 TVTELIPGSSYTVEIFAQVGDGIKSLEPGRKSFCTDPASMASFDCEVVPKEPALVLKWTC 742
T L PG+ YT ++A+ S + S T P ++ S + + L+WT
Sbjct: 263 TAERLEPGTLYTFSVWAEKNGARGSRQ--NVSISTVPNAVTSLSKQDWTNS-TIALRWTA 319
Query: 743 PPGANAGFELEVSSGAWNNATHLESCSSENGTEYRTEVTY--LNFSTSYNISITTVSCGK 800
P G + S W + + T++T L + Y++ TV +
Sbjct: 320 PQGPG-----QSSYSYWVSWVREGMTDPRTQSTSGTDITLKELEAGSLYHL---TVWAER 371
Query: 801 MAAPTRNTCTTGITDPPPPDGSPNITSVSHNSVKVKFSGFEASHGPIKAYAVILTTGEAG 860
N+ T T P N T NSV + + H + Y V G
Sbjct: 372 NEVRGYNSTLTAATAPNEVTDLQNETQTK-NSVMLWWKAPGDPHSQLYVYWV--QWASKG 428
Query: 861 HPS---------------ADVLKYTYEDFKKGASDTYVTYLIRTEEKGRSQSL-SEVLKY 904
HP + Y E + G + + R + +QSL +
Sbjct: 429 HPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWAERNDVASSTQSLCASTYPD 488
Query: 905 EIDVGNESTTLGYYNGKLE---PLGSYRA---------------------CVAGFTNITF 940
+ + + +T Y L P G Y A V G
Sbjct: 489 TVTITSCVSTSAGYGVNLIWSCPQGGYEAFELEVGGQRGSQDRSSCGEAVSVLGLGPARS 548
Query: 941 HPQNKGLIDGAESYVSFSRYSDAVSLPQDPGVICGAVFGCIFGALVIVTVGGFIFWRKKR 1000
+P I VS S V + GVI GA G + L ++ VG IF+ K+R
Sbjct: 549 YPATITTIWDGMKVVSHS----VVCHTESAGVIAGAFVGIL---LFLILVGLLIFFLKRR 601
Query: 1001 KDAKNNEVSFSQIKPKKSKLIRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQPKYAA 1060
K + + I E+F + +K + DSNCGFA++Y+ L LVG SQ + A
Sbjct: 602 NKKKQQKPELRDLVFSSPGDIPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVA 661
Query: 1061 ELAENRGKNRYNNVLPYDISRVKLS-VQTHSTDDYINANYMPGYHSKKDFIATQGPLPNT 1119
+EN KNRY NVLPYD SRV L + DYINA++MPG S ++FIATQGPLP T
Sbjct: 662 SASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQT 721
Query: 1120 LKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWP-SKQAQDYGDITVAMTSEIVLPEWT 1178
+ DFWR+VWE+ + ++MLT C+E GR KCE YWP Q +G + V + E V+ WT
Sbjct: 722 VGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWT 781
Query: 1179 IRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILVH 1238
+R+ + ++ ++ +RQFH+ +WPDHGVP + D L+ F ++R ++ Q+ P +VH
Sbjct: 782 VRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVH 841
Query: 1239 CSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDI 1298
CSAGVGRTGT IA+D L+ Q+++E + + V +R RPLMVQTE QYVFL+QC+L
Sbjct: 842 CSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRF 901
Query: 1299 VR--SQKDSKVDLIYQNTTAMTIYENLAPV 1326
++ +Q ++ ++ Y++ + IYEN+A +
Sbjct: 902 LQQSAQAPAEKEVPYEDVENL-IYENVAAI 930
Score = 123 bits (309), Expect = 1e-27
Identities = 127/505 (25%), Positives = 199/505 (39%), Gaps = 36/505 (7%)
Query: 328 TEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQVFDVTAVNISATSLTLIWK 387
T V + GL PG+ Y +V+ + +G + T V ++T + +S+ L W+
Sbjct: 82 TNVTVDGLGPGSLYTCSVWVEK-DGVNSSVGTVTTATAPNPVRNLTVEAQTNSSIALTWE 140
Query: 388 VSDNESSSNYTYKIHVAGETDSSNL-NVSEPRAVIPGLRSSTFYNITVCPVLGDIEGTPG 446
V D N TY + G+ + + + + L Y +V I +
Sbjct: 141 VPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDRLEPGCLYVFSVWVGKNGINSSRE 200
Query: 447 FLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDAE-----SFQMHITQEGAGNSRVEITTN 501
T P PV + + + + I L W D ++ + T +G G + TTN
Sbjct: 201 TRNATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGG-TETRNTTN 259
Query: 502 QSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTVPSAVFDIHVVYVTTTEMWLDWK 561
S+ L PGT Y F + + NG G+ + V TVP+AV + T + + L W
Sbjct: 260 TSVTAERLEPGTLYTFSVWAE-KNGARGSRQNVSISTVPNAVTSLSKQDWTNSTIALRWT 318
Query: 562 SPDGA--SEYVYHL--VIESKHGSNHTSTYDKAITLQGLIPGTLYNITISPEVDHVWGDP 617
+P G S Y Y + V E ST ITL+ L G+LY++T+ E + V G
Sbjct: 319 APQGPGQSSYSYWVSWVREGMTDPRTQSTSGTDITLKELEAGSLYHLTVWAERNEVRGYN 378
Query: 618 NSTAQYTRPSNVSNIDVSTNTTAATLSWQNF--DDASPTYSYCLLIEKAGN-------SS 668
++ T P+ V+++ T T + + W D S Y Y + G+ +
Sbjct: 379 STLTAATAPNEVTDLQNETQTKNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQA 438
Query: 669 NATQVVTDIGITDATVTELIPGSSYTVEIFAQVGDGIKSLEPGRKSFC--TDPASMASFD 726
N + T V L PG+ Y ++A+ D S + S C T P ++
Sbjct: 439 NWVNQTSRTNETWYKVEALEPGTLYNFTVWAERNDVASSTQ----SLCASTYPDTVTITS 494
Query: 727 CEVVPKEPALVLKWTCPPGANAGFELEVSSGAWNNATHLESCSSENGTEYRTEVTYLNFS 786
C + L W+CP G FELEV G + SC V L +
Sbjct: 495 CVSTSAGYGVNLIWSCPQGGYEAFELEV--GGQRGSQDRSSCGE------AVSVLGLGPA 546
Query: 787 TSYNISITTVSCGKMAAPTRNTCTT 811
SY +ITT+ G C T
Sbjct: 547 RSYPATITTIWDGMKVVSHSVVCHT 571
Score = 108 bits (271), Expect = 3e-23
Identities = 112/469 (23%), Positives = 195/469 (41%), Gaps = 39/469 (8%)
Query: 371 DVTAVNISATSLTLIWKVSDNESSSNYTYKIHVAGETDSSNL-NVSEPRAVIPGLRSSTF 429
++T + +S++L W+V D S N Y + G+ ++ N + + GL +
Sbjct: 35 NLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTTATNVTVDGLGPGSL 94
Query: 430 YNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDA-----ESFQM 484
Y +V + + G + T P PV + V + + I L W D ++ +
Sbjct: 95 YTCSVWVEKDGVNSSVGTVTTATAPNPVRNLTVEAQTNSSIALTWEVPDGPDPQNSTYGV 154
Query: 485 HITQEGAGNSRVEITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTVPSAVF 544
T +G G + T + +I + L PG Y F V G NG + T T P+ V
Sbjct: 155 EYTGDG-GRAGTRSTAHTNITVDRLEPGCLYVFS-VWVGKNGINSSRETRNATTAPNPVR 212
Query: 545 DIHVVYVTTTEMWLDWKSPDG--ASEYVYHLVIESKHGSNHT-STYDKAITLQGLIPGTL 601
++H+ T + + L W+ PDG +Y Y + G T +T + ++T + L PGTL
Sbjct: 213 NLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGGTETRNTTNTSVTAERLEPGTL 272
Query: 602 YNITISPEVDHVWGDPNSTAQYTRPSNVSNIDVS--TNTTAATLSWQNFDDASPTYSYCL 659
Y ++ E + G + + T P+ V+++ TN+T A +YSY +
Sbjct: 273 YTFSVWAEKNGARGSRQNVSISTVPNAVTSLSKQDWTNSTIALRWTAPQGPGQSSYSYWV 332
Query: 660 LIEKAGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQVGD--GIKSLEPGRKSFCT 717
+ G + TQ + TD T+ EL GS Y + ++A+ + G S + T
Sbjct: 333 SWVREGMTDPRTQSTSG---TDITLKELEAGSLYHLTVWAERNEVRGYNS----TLTAAT 385
Query: 718 DPASMASFDCEVVPKEPALVLKWTCPPGANAGFELEVSSGAWNNATH-----------LE 766
P + E K +++L W P ++ +L V W + H +
Sbjct: 386 APNEVTDLQNETQTKN-SVMLWWKAPGDPHS--QLYVYWVQWASKGHPRRGQDPQANWVN 442
Query: 767 SCSSENGTEYRTEVTYLNFSTSYNISITTVSCGKMAAPTRNTCTTGITD 815
S N T Y+ E L T YN ++ +A+ T++ C + D
Sbjct: 443 QTSRTNETWYKVEA--LEPGTLYNFTV-WAERNDVASSTQSLCASTYPD 488
Score = 64.3 bits (155), Expect = 7e-10
Identities = 115/508 (22%), Positives = 189/508 (37%), Gaps = 71/508 (13%)
Query: 53 TGENGITQISSTAESFHKQNGTGTPQVETNTSEDGESSGANDSLRTPEQGSNGTDGASQK 112
TG+ G T+ +T + +G G + T S E G N S+ T
Sbjct: 68 TGDGGTTETRNTTATNVTVDGLGPGSLYT-CSVWVEKDGVNSSVGT-------------- 112
Query: 113 TPSSTGPSPVFDIKAVSISPTNVILTWKSNDTAASEYK-YVVKHKMENEK--TITVVHQP 169
++T P+PV ++ + + +++ LTW+ D + Y V++ + + T + H
Sbjct: 113 VTTATAPNPVRNLTVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAH-- 170
Query: 170 WCNIT--GLRPATSYVFSITPGIGNETWGDPRVIKVITEPIPVSDLRVALTGVRKAALSW 227
NIT L P YVFS+ G N T P PV +L + AL W
Sbjct: 171 -TNITVDRLEPGCLYVFSVWVG-KNGINSSRETRNATTAPNPVRNLHMETQTNSSIALCW 228
Query: 228 SNGNG----TASCRVLLESIGSHEELTQDSRLQVNISGLKPGVQYNINPYLLQSNKTKGD 283
+G + V G E + V L+PG Y + + + N +G
Sbjct: 229 EVPDGPYPQDYTYWVEYTGDGGGTETRNTTNTSVTAERLEPGTLYTFSVW-AEKNGARGS 287
Query: 284 ----PLGTEGGLDAS--------NTERSRAGSPTAPVHDESLV-------GPVDPSSGQQ 324
+ T S +T R +P P G DP + Q
Sbjct: 288 RQNVSISTVPNAVTSLSKQDWTNSTIALRWTAPQGPGQSSYSYWVSWVREGMTDPRT-QS 346
Query: 325 SRDTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQVFDVTAVNISATSLTL 384
+ T++ L LE G+ Y+ TV+++ N G + T +V D+ + S+ L
Sbjct: 347 TSGTDITLKELEAGSLYHLTVWAE-RNEVRGYNSTLTAATAPNEVTDLQNETQTKNSVML 405
Query: 385 IWKVSDNESSSNYTYKIHVA-------GETDSSN-----LNVSEPRAVIPGLRSSTFYNI 432
WK + S Y Y + A G+ +N +E + L T YN
Sbjct: 406 WWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNF 465
Query: 433 TVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTE---IGLAWSSHDA--ESFQMHIT 487
TV D+ + L T P V+ + VST+ + L WS E+F++ +
Sbjct: 466 TVWAERNDVASSTQSLCASTYPDTVT--ITSCVSTSAGYGVNLIWSCPQGGYEAFELEV- 522
Query: 488 QEGAGNSRVEITTNQSIIIGGLFPGTKY 515
G S+ + +++ + GL P Y
Sbjct: 523 -GGQRGSQDRSSCGEAVSVLGLGPARSY 549
Score = 55.1 bits (131), Expect = 5e-07
Identities = 58/220 (26%), Positives = 91/220 (41%), Gaps = 12/220 (5%)
Query: 531 SRTVCNRTVPSAVFDIHVVYVTTTEMWLDWKSPDGASEYVYHLVIESKHGSNHTSTYDKA 590
S T P+ ++ V TT+ + L W+ PDG + ++ T T +
Sbjct: 21 SWTGARAPAPNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTT 80
Query: 591 ---ITLQGLIPGTLYNITISPEVDHVWGDPNSTAQYTRPSNVSNIDVSTNTTAA-TLSWQ 646
+T+ GL PG+LY ++ E D V + T P+ V N+ V T ++ L+W+
Sbjct: 81 ATNVTVDGLGPGSLYTCSVWVEKDGVNSSVGTVTTATAPNPVRNLTVEAQTNSSIALTWE 140
Query: 647 NFDDASPTYSYCLLIEKAGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQVG-DGI 705
D P S +E G+ A T T+ TV L PG Y ++ VG +GI
Sbjct: 141 VPDGPDPQNS-TYGVEYTGDGGRAGTRST--AHTNITVDRLEPGCLYVFSVW--VGKNGI 195
Query: 706 KSLEPGRKSFCTDPASMASFDCEVVPKEPALVLKWTCPPG 745
S R + T P + + E ++ L W P G
Sbjct: 196 NSSRETRNA-TTAPNPVRNLHME-TQTNSSIALCWEVPDG 233
Score = 43.9 bits (102), Expect = 0.001
Identities = 82/388 (21%), Positives = 152/388 (39%), Gaps = 44/388 (11%)
Query: 102 GSNGTDGASQKTPSSTGPSPVFDIKAVSISPTNVILTWKSNDTA-ASEYKYVVKHKMENE 160
G NG + + + ++T P+PV ++ + + +++ L W+ D +Y Y V++ +
Sbjct: 191 GKNGINSSRETRNATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGG 250
Query: 161 KTITVVHQPWCNITG--LRPATSYVFSITPGIGNETWGDPRVIKVITEPIPVSDLRVALT 218
T T + ++T L P T Y FS+ N G + + + T P V+ L
Sbjct: 251 GTETR-NTTNTSVTAERLEPGTLYTFSVWAE-KNGARGSRQNVSISTVPNAVTSLSKQDW 308
Query: 219 GVRKAALSWS--NGNGTASCRVLLESI--GSHEELTQD-SRLQVNISGLKPGVQYNINPY 273
AL W+ G G +S + + G + TQ S + + L+ G Y++ +
Sbjct: 309 TNSTIALRWTAPQGPGQSSYSYWVSWVREGMTDPRTQSTSGTDITLKELEAGSLYHLTVW 368
Query: 274 LLQS-----NKTKGDPLGTEGGLDASNTERSRAG------SPTAPVHDESLVGPVD---- 318
++ N T D N +++ +P P H + V V
Sbjct: 369 AERNEVRGYNSTLTAATAPNEVTDLQNETQTKNSVMLWWKAPGDP-HSQLYVYWVQWASK 427
Query: 319 --PSSGQ-----------QSRDTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTN 365
P GQ ++ +T + LEPGT YN TV+++ N Q++ T
Sbjct: 428 GHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWAE-RNDVASSTQSLCASTY 486
Query: 366 AIQVFDVTAVNISA-TSLTLIWKVSDNESSSNYTYKIHVAGETDSSNLNVSEPRAVIPGL 424
V + V+ SA + LIW + +++ V G+ S + + + GL
Sbjct: 487 PDTVTITSCVSTSAGYGVNLIWSCPQGGYEA---FELEVGGQRGSQDRSSCGEAVSVLGL 543
Query: 425 RSSTFYNITVCPVLGDIEGTPGFLQVHT 452
+ Y T+ + ++ + HT
Sbjct: 544 GPARSYPATITTIWDGMKVVSHSVVCHT 571
>gi|4506323 receptor-type protein tyrosine phosphatase O isoform b
precursor [Homo sapiens]
Length = 1188
Score = 284 bits (727), Expect = 3e-76
Identities = 235/776 (30%), Positives = 379/776 (48%), Gaps = 109/776 (14%)
Query: 625 RPSNVSNIDVSTNTTAA---TLSWQNFDDASPTYSYCLLIEKAGNSSNATQVVTDIGITD 681
+P +VS + V ++TTA T S +N++ + ++ + Q T + +
Sbjct: 435 KPQHVS-VHVLSSTTALMSWTSSQENYNSTIVSVVSLTCQKQKESQRLEKQYCTQVNSSK 493
Query: 682 ATVTELIPGSSYTVEIFAQVGDGIKSLEPGRKSFCTDPASMASF-----DCEVVPKEP-A 735
+ L+PG+ Y V I+ + G I G S DP + A D + P P A
Sbjct: 494 PIIENLVPGAQYQVVIYLRKGPLI-----GPPS---DPVTFAIVPTGIKDLMLYPLGPTA 545
Query: 736 LVLKWTCPP-GANAGFELEVSSGAWNNATHLESCSSENGTEYRTEVTYLNFSTS------ 788
+VL WT P G + +E+ +N AT +SE T Y T ++ + S
Sbjct: 546 VVLSWTRPYLGVFRKYVVEMFY--FNPAT----MTSEWTTYYEIAAT-VSLTASVRIANL 598
Query: 789 -----YNISITTVSCGKMAAPTRNTCTTGITDPPPPDGSPNITSVSHNSVKVKFSGF--- 840
YN +T V+ G ++ T P +P ITSV + + + S
Sbjct: 599 LPAWYYNFRVTMVTWGDPELSCCDSSTISFITAPV---APEITSVEYFNSLLYISWTYGD 655
Query: 841 ---EASHGPIKAYAVI--------------LTTGEAGHPSADVLKYTYEDFKKGASDTYV 883
+ SH + + V+ + T P D+ + + S+T +
Sbjct: 656 DTTDLSHSRMLHWMVVAEGKKKIKKSVTRNVMTAILSLPPGDIYNLSVTACTERGSNTSM 715
Query: 884 TYLIRTEEKGRSQSLSEVLKYEIDVGN---ESTTLGYYNGKLEPLGS-YRACVAGFTNIT 939
L++ E +SL V K + V E ++ + +GS + + ++
Sbjct: 716 LRLVKLEP-APPKSLFAVNKTQTSVTLLWVEEGVADFFEVFCQQVGSSQKTKLQEPVAVS 774
Query: 940 FHPQNKGLIDGAESY----VSFSRYSDAVSL---------PQDPGVICGAVFGCIFGALV 986
H + A +Y SFS S +V +P V+ +V + L+
Sbjct: 775 SHVVTISSLLPATAYNCSVTSFSHDSPSVPTFIAVSTMVTEMNPNVVVISVLAILSTLLI 834
Query: 987 IVTVGGFIFWRKK-----RKDAKNNEVSFSQIKP-------------KKSKL---IRVEN 1025
+ + I RKK R+ V+F+ ++ KK KL +++++
Sbjct: 835 GLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGKLPYNWSKNGLKKRKLTNPVQLDD 894
Query: 1026 FEAYFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKL- 1084
F+AY K DS+ F+ ++E+LKL+G+ P +AA+L NR KNRY N+LPYD SRV+L
Sbjct: 895 FDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLV 954
Query: 1085 SVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQ 1144
S+ DYINANY+PGY+S +++IATQGPLP T DFW+MV ++ I+MLT+C E+
Sbjct: 955 SMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEK 1014
Query: 1145 GRTKCEEYWP-SKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSW 1203
R KC+ YWP +++ YGDITV M SE +W R F + E + F++T+W
Sbjct: 1015 RRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRIN--YADEMQDVMHFNYTAW 1072
Query: 1204 PDHGVP--DTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIEN 1261
PDHGVP + + ++ F ++VR +S + P+++HCSAGVGRTGTFIA+DRL+ I +
Sbjct: 1073 PDHGVPTANAAESILQFVHMVRQQATKS--KGPMIIHCSAGVGRTGTFIALDRLLQHIRD 1130
Query: 1262 ENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCV--LDIVRSQKDSKVDLIYQNTT 1315
VD+ G+V ++R +R MVQTE+QY+F++QCV + + + Q+ D+IY+N +
Sbjct: 1131 HEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCISDVIYENVS 1186
Score = 36.6 bits (83), Expect = 0.17
Identities = 91/410 (22%), Positives = 158/410 (38%), Gaps = 68/410 (16%)
Query: 462 VTVVSTTEIGLAWSSHDAESFQMHIT-------QEGAGNSRVEI-----TTNQSIIIGGL 509
V V+S+T ++W+S E++ I Q+ + R+E + II L
Sbjct: 441 VHVLSSTTALMSWTSSQ-ENYNSTIVSVVSLTCQKQKESQRLEKQYCTQVNSSKPIIENL 499
Query: 510 FPGTKYCFEI-VPKGPNGTEGASRTVCNRTVPSAVFDIHVVYVTTTEMWLDWKSP--DGA 566
PG +Y I + KGP S V VP+ + D+ + + T + L W P
Sbjct: 500 VPGAQYQVVIYLRKGPL-IGPPSDPVTFAIVPTGIKDLMLYPLGPTAVVLSWTRPYLGVF 558
Query: 567 SEYVYHLVI--ESKHGSNHTSTYDKAITLQ--------GLIPGTLYNITISPEVDHVWGD 616
+YV + + S T+ Y+ A T+ L+P YN ++ WGD
Sbjct: 559 RKYVVEMFYFNPATMTSEWTTYYEIAATVSLTASVRIANLLPAWYYNFRVTMVT---WGD 615
Query: 617 P------NSTAQY-TRPSNVSNIDVSTNTTAATLSWQNFDDASP-TYSYCL--LIEKAGN 666
P +ST + T P V + +SW DD + ++S L ++ G
Sbjct: 616 PELSCCDSSTISFITAPVAPEITSVEYFNSLLYISWTYGDDTTDLSHSRMLHWMVVAEGK 675
Query: 667 SSNATQVVTDIGITDATVTELIPGSSYTVEIFAQVGDG-------IKSLEPGRKSFCTDP 719
V ++ + L PG Y + + A G + LEP P
Sbjct: 676 KKIKKSVTRNVM---TAILSLPPGDIYNLSVTACTERGSNTSMLRLVKLEPA------PP 726
Query: 720 ASMASFDCEVVPKEPALVLKWTCPPGANAGFELEVSSGAWNNATHLESCSSENGTEYRTE 779
S+ + V + ++ L W G FE+ + T L+ + + +
Sbjct: 727 KSLFA----VNKTQTSVTLLWV-EEGVADFFEVFCQQVGSSQKTKLQEPVAVSS--HVVT 779
Query: 780 VTYLNFSTSYNISITTVSCGKMAAPTRNTCTTGITDPPPPDGSPNITSVS 829
++ L +T+YN S+T+ S + PT +T +T+ +PN+ +S
Sbjct: 780 ISSLLPATAYNCSVTSFSHDSPSVPTFIAVSTMVTEM-----NPNVVVIS 824
Score = 35.8 bits (81), Expect = 0.28
Identities = 41/160 (25%), Positives = 67/160 (41%), Gaps = 18/160 (11%)
Query: 325 SRDTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQVFDVTAVNISATSLTL 384
+R+ ++ L PG YN +V + G+ + + + AVN + TS+TL
Sbjct: 683 TRNVMTAILSLPPGDIYNLSVTACTERGSNTSMLRL-VKLEPAPPKSLFAVNKTQTSVTL 741
Query: 385 IWKVSDNESSSNYTYKIHVAGETDSSNLNVSEPRAV------IPGLRSSTFYNITVCPVL 438
+W E +++ +++ S + EP AV I L +T YN +V
Sbjct: 742 LWV---EEGVADF-FEVFCQQVGSSQKTKLQEPVAVSSHVVTISSLLPATAYNCSVTSFS 797
Query: 439 GDIEGTPGFLQVHT------PPVPVSDFRVTVVSTTEIGL 472
D P F+ V T P V V + ++ST IGL
Sbjct: 798 HDSPSVPTFIAVSTMVTEMNPNVVVISV-LAILSTLLIGL 836
Score = 34.3 bits (77), Expect = 0.82
Identities = 69/291 (23%), Positives = 103/291 (35%), Gaps = 49/291 (16%)
Query: 119 PSPVFDIKAVSISPTNVILTWKSNDTAASEYKYVVKHKMENEKTI------------TVV 166
P+ + D+ + PT V+L+W + KYVV+ N T+ TV
Sbjct: 530 PTGIKDLMLYPLGPTAVVLSW-TRPYLGVFRKYVVEMFYFNPATMTSEWTTYYEIAATVS 588
Query: 167 HQPWCNITGLRPATSYVFSITPGIGNETWGDPRV-------IKVITEPIPVSDLRVALTG 219
I L PA Y F +T TWGDP + I IT P+ V
Sbjct: 589 LTASVRIANLLPAWYYNFRVT----MVTWGDPELSCCDSSTISFITAPVAPEITSVEYFN 644
Query: 220 VRKAALSWSNGNGTASCRVLLESIGSHEELTQDSRLQVNISGLKPGVQYNINPYLLQSNK 279
+SW+ G+ T SH + + +K V N+ +L +
Sbjct: 645 -SLLYISWTYGDDTTDL--------SHSRMLHWMVVAEGKKKIKKSVTRNVMTAIL--SL 693
Query: 280 TKGDPLGTEGGLDASNTERSRAGSPTAPVHDESLVGPVDPSS--GQQSRDTEVLLVGLEP 337
GD + S T + GS T+ + L P P S T V L+ +E
Sbjct: 694 PPGDI------YNLSVTACTERGSNTSMLRLVKL-EPAPPKSLFAVNKTQTSVTLLWVEE 746
Query: 338 GTRYNATVYSQAANGTE----GQPQAIEFRTNAI-QVFDVTAVNISATSLT 383
G V+ Q ++ +P A+ I + TA N S TS +
Sbjct: 747 GVADFFEVFCQQVGSSQKTKLQEPVAVSSHVVTISSLLPATAYNCSVTSFS 797
>gi|13677220 receptor-type protein tyrosine phosphatase O isoform d
precursor [Homo sapiens]
Length = 377
Score = 279 bits (714), Expect = 1e-74
Identities = 145/334 (43%), Positives = 220/334 (65%), Gaps = 14/334 (4%)
Query: 991 GGFIFWRKKRKDAKNNEVSFSQIKPKKSKL---IRVENFEAYFKKQQADSNCGFAEEYED 1047
G F+ + +D K ++S+ KK KL +++++F+AY K DS+ F+ ++E+
Sbjct: 47 GTFVNFASLERDGKL-PYNWSKNGLKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEE 105
Query: 1048 LKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKL-SVQTHSTDDYINANYMPGYHSK 1106
LKL+G+ P +AA+L NR KNRY N+LPYD SRV+L S+ DYINANY+PGY+S
Sbjct: 106 LKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSP 165
Query: 1107 KDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWP-SKQAQDYGDIT 1165
+++IATQGPLP T DFW+MV ++ I+MLT+C E+ R KC+ YWP +++ YGDIT
Sbjct: 166 QEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDIT 225
Query: 1166 VAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVP--DTTDLLINFRYLVR 1223
V M SE +W R F + E + F++T+WPDHGVP + + ++ F ++VR
Sbjct: 226 VEMISEEEQDDWACRHFRIN--YADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVR 283
Query: 1224 DYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQ 1283
+S + P+++HCSAGVGRTGTFIA+DRL+ I + VD+ G+V ++R +R MVQ
Sbjct: 284 QQATKS--KGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQ 341
Query: 1284 TEDQYVFLNQCV--LDIVRSQKDSKVDLIYQNTT 1315
TE+QY+F++QCV + + + Q+ D+IY+N +
Sbjct: 342 TEEQYIFIHQCVQLMWMKKKQQFCISDVIYENVS 375
>gi|13677216 receptor-type protein tyrosine phosphatase O isoform d
precursor [Homo sapiens]
Length = 377
Score = 279 bits (714), Expect = 1e-74
Identities = 145/334 (43%), Positives = 220/334 (65%), Gaps = 14/334 (4%)
Query: 991 GGFIFWRKKRKDAKNNEVSFSQIKPKKSKL---IRVENFEAYFKKQQADSNCGFAEEYED 1047
G F+ + +D K ++S+ KK KL +++++F+AY K DS+ F+ ++E+
Sbjct: 47 GTFVNFASLERDGKL-PYNWSKNGLKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEE 105
Query: 1048 LKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKL-SVQTHSTDDYINANYMPGYHSK 1106
LKL+G+ P +AA+L NR KNRY N+LPYD SRV+L S+ DYINANY+PGY+S
Sbjct: 106 LKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSP 165
Query: 1107 KDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWP-SKQAQDYGDIT 1165
+++IATQGPLP T DFW+MV ++ I+MLT+C E+ R KC+ YWP +++ YGDIT
Sbjct: 166 QEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDIT 225
Query: 1166 VAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVP--DTTDLLINFRYLVR 1223
V M SE +W R F + E + F++T+WPDHGVP + + ++ F ++VR
Sbjct: 226 VEMISEEEQDDWACRHFRIN--YADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVR 283
Query: 1224 DYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQ 1283
+S + P+++HCSAGVGRTGTFIA+DRL+ I + VD+ G+V ++R +R MVQ
Sbjct: 284 QQATKS--KGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQ 341
Query: 1284 TEDQYVFLNQCV--LDIVRSQKDSKVDLIYQNTT 1315
TE+QY+F++QCV + + + Q+ D+IY+N +
Sbjct: 342 TEEQYIFIHQCVQLMWMKKKQQFCISDVIYENVS 375
>gi|13677222 receptor-type protein tyrosine phosphatase O isoform c
precursor [Homo sapiens]
Length = 405
Score = 278 bits (711), Expect = 3e-74
Identities = 140/309 (45%), Positives = 209/309 (67%), Gaps = 13/309 (4%)
Query: 1016 KKSKL---IRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYN 1072
KK KL +++++F+AY K DS+ F+ ++E+LKL+G+ P +AA+L NR KNRY
Sbjct: 99 KKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYT 158
Query: 1073 NVLPYDISRVKL-SVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKN 1131
N+LPYD SRV+L S+ DYINANY+PGY+S +++IATQGPLP T DFW+MV ++
Sbjct: 159 NILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQK 218
Query: 1132 VYAIIMLTKCVEQGRTKCEEYWP-SKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTS 1190
I+MLT+C E+ R KC+ YWP +++ YGDITV M SE +W R F +
Sbjct: 219 SQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRIN--YAD 276
Query: 1191 ESHPLRQFHFTSWPDHGVP--DTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGT 1248
E + F++T+WPDHGVP + + ++ F ++VR +S + P+++HCSAGVGRTGT
Sbjct: 277 EMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKS--KGPMIIHCSAGVGRTGT 334
Query: 1249 FIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCV--LDIVRSQKDSK 1306
FIA+DRL+ I + VD+ G+V ++R +R MVQTE+QY+F++QCV + + + Q+
Sbjct: 335 FIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCI 394
Query: 1307 VDLIYQNTT 1315
D+IY+N +
Sbjct: 395 SDVIYENVS 403
>gi|13677218 receptor-type protein tyrosine phosphatase O isoform c
precursor [Homo sapiens]
Length = 405
Score = 278 bits (711), Expect = 3e-74
Identities = 140/309 (45%), Positives = 209/309 (67%), Gaps = 13/309 (4%)
Query: 1016 KKSKL---IRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYN 1072
KK KL +++++F+AY K DS+ F+ ++E+LKL+G+ P +AA+L NR KNRY
Sbjct: 99 KKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYT 158
Query: 1073 NVLPYDISRVKL-SVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKN 1131
N+LPYD SRV+L S+ DYINANY+PGY+S +++IATQGPLP T DFW+MV ++
Sbjct: 159 NILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQK 218
Query: 1132 VYAIIMLTKCVEQGRTKCEEYWP-SKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTS 1190
I+MLT+C E+ R KC+ YWP +++ YGDITV M SE +W R F +
Sbjct: 219 SQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRIN--YAD 276
Query: 1191 ESHPLRQFHFTSWPDHGVP--DTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGT 1248
E + F++T+WPDHGVP + + ++ F ++VR +S + P+++HCSAGVGRTGT
Sbjct: 277 EMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKS--KGPMIIHCSAGVGRTGT 334
Query: 1249 FIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCV--LDIVRSQKDSK 1306
FIA+DRL+ I + VD+ G+V ++R +R MVQTE+QY+F++QCV + + + Q+
Sbjct: 335 FIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCI 394
Query: 1307 VDLIYQNTT 1315
D+IY+N +
Sbjct: 395 SDVIYENVS 403
>gi|13677214 receptor-type protein tyrosine phosphatase O isoform a
precursor [Homo sapiens]
Length = 1216
Score = 278 bits (711), Expect = 3e-74
Identities = 140/309 (45%), Positives = 209/309 (67%), Gaps = 13/309 (4%)
Query: 1016 KKSKL---IRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYN 1072
KK KL +++++F+AY K DS+ F+ ++E+LKL+G+ P +AA+L NR KNRY
Sbjct: 910 KKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYT 969
Query: 1073 NVLPYDISRVKL-SVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKN 1131
N+LPYD SRV+L S+ DYINANY+PGY+S +++IATQGPLP T DFW+MV ++
Sbjct: 970 NILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQK 1029
Query: 1132 VYAIIMLTKCVEQGRTKCEEYWP-SKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTS 1190
I+MLT+C E+ R KC+ YWP +++ YGDITV M SE +W R F +
Sbjct: 1030 SQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRIN--YAD 1087
Query: 1191 ESHPLRQFHFTSWPDHGVP--DTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGT 1248
E + F++T+WPDHGVP + + ++ F ++VR +S + P+++HCSAGVGRTGT
Sbjct: 1088 EMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKS--KGPMIIHCSAGVGRTGT 1145
Query: 1249 FIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCV--LDIVRSQKDSK 1306
FIA+DRL+ I + VD+ G+V ++R +R MVQTE+QY+F++QCV + + + Q+
Sbjct: 1146 FIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCI 1205
Query: 1307 VDLIYQNTT 1315
D+IY+N +
Sbjct: 1206 SDVIYENVS 1214
Score = 36.6 bits (83), Expect = 0.17
Identities = 91/410 (22%), Positives = 158/410 (38%), Gaps = 68/410 (16%)
Query: 462 VTVVSTTEIGLAWSSHDAESFQMHIT-------QEGAGNSRVEI-----TTNQSIIIGGL 509
V V+S+T ++W+S E++ I Q+ + R+E + II L
Sbjct: 441 VHVLSSTTALMSWTSSQ-ENYNSTIVSVVSLTCQKQKESQRLEKQYCTQVNSSKPIIENL 499
Query: 510 FPGTKYCFEI-VPKGPNGTEGASRTVCNRTVPSAVFDIHVVYVTTTEMWLDWKSP--DGA 566
PG +Y I + KGP S V VP+ + D+ + + T + L W P
Sbjct: 500 VPGAQYQVVIYLRKGPL-IGPPSDPVTFAIVPTGIKDLMLYPLGPTAVVLSWTRPYLGVF 558
Query: 567 SEYVYHLVI--ESKHGSNHTSTYDKAITLQ--------GLIPGTLYNITISPEVDHVWGD 616
+YV + + S T+ Y+ A T+ L+P YN ++ WGD
Sbjct: 559 RKYVVEMFYFNPATMTSEWTTYYEIAATVSLTASVRIANLLPAWYYNFRVTMVT---WGD 615
Query: 617 P------NSTAQY-TRPSNVSNIDVSTNTTAATLSWQNFDDASP-TYSYCL--LIEKAGN 666
P +ST + T P V + +SW DD + ++S L ++ G
Sbjct: 616 PELSCCDSSTISFITAPVAPEITSVEYFNSLLYISWTYGDDTTDLSHSRMLHWMVVAEGK 675
Query: 667 SSNATQVVTDIGITDATVTELIPGSSYTVEIFAQVGDG-------IKSLEPGRKSFCTDP 719
V ++ + L PG Y + + A G + LEP P
Sbjct: 676 KKIKKSVTRNVM---TAILSLPPGDIYNLSVTACTERGSNTSMLRLVKLEPA------PP 726
Query: 720 ASMASFDCEVVPKEPALVLKWTCPPGANAGFELEVSSGAWNNATHLESCSSENGTEYRTE 779
S+ + V + ++ L W G FE+ + T L+ + + +
Sbjct: 727 KSLFA----VNKTQTSVTLLWV-EEGVADFFEVFCQQVGSSQKTKLQEPVAVSS--HVVT 779
Query: 780 VTYLNFSTSYNISITTVSCGKMAAPTRNTCTTGITDPPPPDGSPNITSVS 829
++ L +T+YN S+T+ S + PT +T +T+ +PN+ +S
Sbjct: 780 ISSLLPATAYNCSVTSFSHDSPSVPTFIAVSTMVTEM-----NPNVVVIS 824
Score = 35.8 bits (81), Expect = 0.28
Identities = 41/160 (25%), Positives = 67/160 (41%), Gaps = 18/160 (11%)
Query: 325 SRDTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQVFDVTAVNISATSLTL 384
+R+ ++ L PG YN +V + G+ + + + AVN + TS+TL
Sbjct: 683 TRNVMTAILSLPPGDIYNLSVTACTERGSNTSMLRL-VKLEPAPPKSLFAVNKTQTSVTL 741
Query: 385 IWKVSDNESSSNYTYKIHVAGETDSSNLNVSEPRAV------IPGLRSSTFYNITVCPVL 438
+W E +++ +++ S + EP AV I L +T YN +V
Sbjct: 742 LWV---EEGVADF-FEVFCQQVGSSQKTKLQEPVAVSSHVVTISSLLPATAYNCSVTSFS 797
Query: 439 GDIEGTPGFLQVHT------PPVPVSDFRVTVVSTTEIGL 472
D P F+ V T P V V + ++ST IGL
Sbjct: 798 HDSPSVPTFIAVSTMVTEMNPNVVVISV-LAILSTLLIGL 836
Score = 34.3 bits (77), Expect = 0.82
Identities = 69/291 (23%), Positives = 103/291 (35%), Gaps = 49/291 (16%)
Query: 119 PSPVFDIKAVSISPTNVILTWKSNDTAASEYKYVVKHKMENEKTI------------TVV 166
P+ + D+ + PT V+L+W + KYVV+ N T+ TV
Sbjct: 530 PTGIKDLMLYPLGPTAVVLSW-TRPYLGVFRKYVVEMFYFNPATMTSEWTTYYEIAATVS 588
Query: 167 HQPWCNITGLRPATSYVFSITPGIGNETWGDPRV-------IKVITEPIPVSDLRVALTG 219
I L PA Y F +T TWGDP + I IT P+ V
Sbjct: 589 LTASVRIANLLPAWYYNFRVT----MVTWGDPELSCCDSSTISFITAPVAPEITSVEYFN 644
Query: 220 VRKAALSWSNGNGTASCRVLLESIGSHEELTQDSRLQVNISGLKPGVQYNINPYLLQSNK 279
+SW+ G+ T SH + + +K V N+ +L +
Sbjct: 645 -SLLYISWTYGDDTTDL--------SHSRMLHWMVVAEGKKKIKKSVTRNVMTAIL--SL 693
Query: 280 TKGDPLGTEGGLDASNTERSRAGSPTAPVHDESLVGPVDPSS--GQQSRDTEVLLVGLEP 337
GD + S T + GS T+ + L P P S T V L+ +E
Sbjct: 694 PPGDI------YNLSVTACTERGSNTSMLRLVKL-EPAPPKSLFAVNKTQTSVTLLWVEE 746
Query: 338 GTRYNATVYSQAANGTE----GQPQAIEFRTNAI-QVFDVTAVNISATSLT 383
G V+ Q ++ +P A+ I + TA N S TS +
Sbjct: 747 GVADFFEVFCQQVGSSQKTKLQEPVAVSSHVVTISSLLPATAYNCSVTSFS 797
>gi|18860894 protein tyrosine phosphatase, receptor type, D isoform 4
precursor [Homo sapiens]
Length = 1501
Score = 274 bits (700), Expect = 5e-73
Identities = 250/944 (26%), Positives = 412/944 (43%), Gaps = 103/944 (10%)
Query: 424 LRSSTFYNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDAESFQ 483
+R S Y LG IE + V P P VT + T I L W S + E
Sbjct: 294 VRQSANYTCVAMSTLGVIEAIAQ-ITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVS 352
Query: 484 MHITQEGAGNSR-----VEITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRT 538
+I Q NS ++ + GL P + Y F +V G S V +T
Sbjct: 353 YYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQT 412
Query: 539 VP----SAVFDIHVVYVTTTEMWLDWKSPDGASEY-----VYHLVIESKHGSN---HTST 586
SA D+ +++T + + WK P+ + VY+ + ++H +N H
Sbjct: 413 SEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVA 472
Query: 587 YDKAITLQGLIPGTLYNITISPEVDHVWGDPNSTAQYTRPSNVSNIDVS-----TNTTAA 641
+ T+ L+P Y++ + G +S Q + V ++ + T+
Sbjct: 473 DSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSI 532
Query: 642 TLSWQNFDDASPTYSYCLLIEKAGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQV 701
LSW S T + L+ K G ++ + G T + L P S Y + A+
Sbjct: 533 LLSWT--PPRSDTIANYELVYKDGEHGEEQRITIEPG-TSYRLQGLKPNSLYYFRLAARS 589
Query: 702 GDGIKSLEPGRKSFCTDPASMASFDCEVVPKEPALVLKWTCPPGANAGFELEVSSGAWNN 761
G+ + + +F + V K L L W P N+ ++ +++
Sbjct: 590 PQGLGASTAEISARTMQSMFAKNFHVKAVMKTSVL-LSWEIPENYNSAMPFKI---LYDD 645
Query: 762 ATHLESCSSENGTEYRTEVTYLNFSTSYNISITT---VSCGKMAAPTRNTCTTGITDPPP 818
+E +G + + L SY+ +T + G T T + P
Sbjct: 646 GKMVEEV---DGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPA 702
Query: 819 PDGSPNITSVSHNSVKVKFSGFEASHGPIKAYAVIL-----TTGEAGHPSADVLKYTYED 873
G N+ + + V+ A+ IK Y +I+ + G+ P + ++
Sbjct: 703 FIGKTNLDGM----ITVQLPEVPANEN-IKGYYIIIVPLKKSRGKFIKPWESPDEMELDE 757
Query: 874 FKKGASDTY--VTYLIRTEEKGRSQSLSEVLKYEIDVGNESTTLGYYNGKLEPLGSYRAC 931
K S + Y E K + +VL E +G++ G+ N +L+ Y
Sbjct: 758 LLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFF 817
Query: 932 VAGFTNITFHPQNKGLIDGAESYV-SFSRYSD-AVSLPQDPGVIC----------GAVFG 979
V +++ AES + + S YSD VS+ DP I G V
Sbjct: 818 VLA------------VMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLA 865
Query: 980 CIFGALVIVTVGGFIFWRKKRKDAKNNEVSFSQIK------PKKSKLIRVENFEA----- 1028
+F +++ + + +++KR ++ + + S K P +R NF+
Sbjct: 866 VVFIICIVIAI---LLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMAS 922
Query: 1029 -----------YFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPY 1077
+ ++ +A+ N F++EYE + G + L N+ KNRY NV+ Y
Sbjct: 923 HPPIPILELADHIERLKANDNLKFSQEYESID-PGQQFTWEHSNLEVNKPKNRYANVIAY 981
Query: 1078 DISRVKLS-VQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAII 1136
D SRV LS ++ DY+NANY+ GY + +IATQG LP T DFWRM+WE+ ++
Sbjct: 982 DHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVV 1041
Query: 1137 MLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLR 1196
M+TK E+ R KC++YWPS+ + +G + V + + L + +R F + +SE +R
Sbjct: 1042 MMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVR 1101
Query: 1197 QFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPES-PILVHCSAGVGRTGTFIAIDRL 1255
QF FT+WPDHGVP+ + F +R +PP++ P++VHCSAGVGRTG FI ID +
Sbjct: 1102 QFQFTAWPDHGVPEHPTPFLAF---LRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAM 1158
Query: 1256 IYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIV 1299
+ +I++E TVD+YG V +R R MVQTEDQY+F++ +L+ V
Sbjct: 1159 LERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV 1202
Score = 209 bits (533), Expect = 1e-53
Identities = 111/287 (38%), Positives = 168/287 (58%), Gaps = 6/287 (2%)
Query: 1021 IRVENFEAYFKK----QQADSNCGFAEEYEDLKLVGISQPKY-AAELAENRGKNRYNNVL 1075
+ N AY +K + ++ G E++ L ++ +A L N+ KNR N++
Sbjct: 1209 VPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIM 1268
Query: 1076 PYDISRVKLS-VQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYA 1134
PY+ +RV L ++ DYINA+++ GY +K +IATQGPL T +DFWRM+WE N
Sbjct: 1269 PYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTI 1328
Query: 1135 IIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHP 1194
++MLTK E GR KC +YWP++++ Y V +E +P++ +R+F V + + +S
Sbjct: 1329 VVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRT 1388
Query: 1195 LRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDR 1254
+RQF FT WP+ GVP + + I+F V +Q + PI VHCSAGVGRTG FI +
Sbjct: 1389 VRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSI 1448
Query: 1255 LIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRS 1301
++ ++ E VD++ V LR RP MVQTEDQY F + L+ + S
Sbjct: 1449 VLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS 1495
Score = 46.6 bits (109), Expect = 2e-04
Identities = 70/306 (22%), Positives = 115/306 (37%), Gaps = 32/306 (10%)
Query: 378 SATSLTLIWKVSDNESSSNY--TYKIHVAGETDSSNLNVSEPRAVIPGLRSSTFYNITVC 435
+ATS+TL W + E S Y +K + E V+ R + GL + Y V
Sbjct: 335 TATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVV 394
Query: 436 PVLGDIEGTPG--FLQVHTPPVPVS---DFRVTVVSTTEIGLAWSSHDAES--------- 481
V G P L + P S D + ++S+T I + W + +
Sbjct: 395 AVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVY 454
Query: 482 FQMHITQEGAGNSRVEITTNQSIIIGGLFPGTKY-----CFEIVPKGPNGTEGASRTVCN 536
+ M TQ + + +Q IG L P Y F + GP ++ + +
Sbjct: 455 YTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSD--IQVITQ 512
Query: 537 RTVPSAVFDIHVVYVTTTEMWLDWKSPDGASEYVYHLVI-ESKHGSNHTSTYDKAIT--L 593
VP + + T + L W P + Y LV + +HG T + + L
Sbjct: 513 TGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRL 572
Query: 594 QGLIPGTLYNITISPEVDHVWGDPNS--TAQYTRPSNVSNIDV-STNTTAATLSW---QN 647
QGL P +LY ++ G + +A+ + N V + T+ LSW +N
Sbjct: 573 QGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSMFAKNFHVKAVMKTSVLLSWEIPEN 632
Query: 648 FDDASP 653
++ A P
Sbjct: 633 YNSAMP 638
Score = 45.8 bits (107), Expect = 3e-04
Identities = 55/260 (21%), Positives = 102/260 (39%), Gaps = 27/260 (10%)
Query: 328 TEVLLVGLEPGTRYNATVYS--QAANGTEGQPQAIEFRTNAIQVF--DVTAVNISATSLT 383
T + GL P + Y V + G +P + A DV A +S+T++
Sbjct: 376 TRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTIL 435
Query: 384 LIWKVSDNESSSNYTYKIHVAGETDSS-----NLNVSEPRAVIPG---------LRSSTF 429
+ WK + + Y+++ + NV++ + G ++ F
Sbjct: 436 VQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAF 495
Query: 430 YNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDAESFQ----MH 485
+I P+ DI+ Q P P++ F+ S T I L+W+ +++ ++
Sbjct: 496 TSIGDGPLSSDIQV---ITQTGVPGQPLN-FKAEPESETSILLSWTPPRSDTIANYELVY 551
Query: 486 ITQEGAGNSRVEITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTVPSA-VF 544
E R+ I S + GL P + Y F + + P G ++ + RT+ S
Sbjct: 552 KDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSMFAK 611
Query: 545 DIHVVYVTTTEMWLDWKSPD 564
+ HV V T + L W+ P+
Sbjct: 612 NFHVKAVMKTSVLLSWEIPE 631
>gi|104487002 protein tyrosine phosphatase, receptor type, D isoform 5
precursor [Homo sapiens]
Length = 1502
Score = 269 bits (688), Expect = 1e-71
Identities = 252/945 (26%), Positives = 407/945 (43%), Gaps = 101/945 (10%)
Query: 424 LRSSTFYNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDAESFQ 483
+R S Y LG IE + V P P VT + T I L W S + E
Sbjct: 291 VRQSANYTCVAMSTLGVIEAIAQ-ITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVS 349
Query: 484 MHITQEGAGNSR-----VEITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRT 538
+I Q NS ++ + GL P + Y F +V G S V +T
Sbjct: 350 YYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQT 409
Query: 539 VP----SAVFDIHVVYVTTTEMWLDWKSPDGASEY-----VYHLVIESKHGSN---HTST 586
SA D+ +++T + + WK P+ + VY+ + ++H +N H
Sbjct: 410 SEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVA 469
Query: 587 YDKAITLQGLIPGTLYNITISPEVDHVWGDPNSTAQYTRPSNVSNIDVS-----TNTTAA 641
+ T+ L+P Y++ + G +S Q + V ++ + T+
Sbjct: 470 DSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSI 529
Query: 642 TLSWQNFDDASPTYSYCLLIEKAGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQV 701
LSW S T + L+ K G ++ + G T + L P S Y + A+
Sbjct: 530 LLSWT--PPRSDTIANYELVYKDGEHGEEQRITIEPG-TSYRLQGLKPNSLYYFRLAARS 586
Query: 702 GDGIKSLEPGRKSFCTDPASMASFDCEVVPKEPALVLKWTCPPGANAGFELEVSSGAWNN 761
G+ + + +F + V K L L W P N+ ++ +++
Sbjct: 587 PQGLGASTAEISARTMQSMFAKNFHVKAVMKTSVL-LSWEIPENYNSAMPFKI---LYDD 642
Query: 762 ATHLESCSSENGTEYRTEVTYLNFSTSYNISITT---VSCGKMAAPTRNTCTTGITDPPP 818
+E +G + + L SY+ +T + G T T + P
Sbjct: 643 GKMVEEV---DGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPA 699
Query: 819 PDGSPNITSVSHNSVKVKFSGFEASHGPIKAYAVIL-----TTGEAGHPSADVLKYTYED 873
G N+ + + V+ A+ IK Y +I+ + G+ P + ++
Sbjct: 700 FIGKTNLDGM----ITVQLPEVPANEN-IKGYYIIIVPLKKSRGKFIKPWESPDEMELDE 754
Query: 874 FKKGASDTY--VTYLIRTEEKGRSQSLSEVLKYEIDVGNESTTLGYYNGKLEPLGSYRAC 931
K S + Y E K + +VL E +G++ G+ N +L+ Y
Sbjct: 755 LLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFF 814
Query: 932 VAGFTNITFHPQNKGLIDGAESYV-SFSRYSD-AVSLPQDPGVICGA------VFGCIFG 983
V +++ AES + + S YSD VS+ DP I V G +
Sbjct: 815 VLA------------VMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLA 862
Query: 984 ALVIVTVGGFIFWRKKRKDAKNNEVSFSQIKPKKSKLI-----------RVENFEA---- 1028
+ I+ + I K + D K E + +K I R NF+
Sbjct: 863 VVFIICIVIAILLYKSKPDRKRAESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMA 922
Query: 1029 ------------YFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLP 1076
+ ++ +A+ N F++EYE + G + L N+ KNRY NV+
Sbjct: 923 SHPPIPILELADHIERLKANDNLKFSQEYESID-PGQQFTWEHSNLEVNKPKNRYANVIA 981
Query: 1077 YDISRVKLS-VQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAI 1135
YD SRV LS ++ DY+NANY+ GY + +IATQG LP T DFWRM+WE+ +
Sbjct: 982 YDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATV 1041
Query: 1136 IMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPL 1195
+M+TK E+ R KC++YWPS+ + +G + V + + L + +R F + +SE +
Sbjct: 1042 VMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREV 1101
Query: 1196 RQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPES-PILVHCSAGVGRTGTFIAIDR 1254
RQF FT+WPDHGVP+ + F +R +PP++ P++VHCSAGVGRTG FI ID
Sbjct: 1102 RQFQFTAWPDHGVPEHPTPFLAF---LRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDA 1158
Query: 1255 LIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIV 1299
++ +I++E TVD+YG V +R R MVQTEDQY+F++ +L+ V
Sbjct: 1159 MLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV 1203
Score = 209 bits (533), Expect = 1e-53
Identities = 111/287 (38%), Positives = 168/287 (58%), Gaps = 6/287 (2%)
Query: 1021 IRVENFEAYFKK----QQADSNCGFAEEYEDLKLVGISQPKY-AAELAENRGKNRYNNVL 1075
+ N AY +K + ++ G E++ L ++ +A L N+ KNR N++
Sbjct: 1210 VPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIM 1269
Query: 1076 PYDISRVKLS-VQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYA 1134
PY+ +RV L ++ DYINA+++ GY +K +IATQGPL T +DFWRM+WE N
Sbjct: 1270 PYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTI 1329
Query: 1135 IIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHP 1194
++MLTK E GR KC +YWP++++ Y V +E +P++ +R+F V + + +S
Sbjct: 1330 VVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRT 1389
Query: 1195 LRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDR 1254
+RQF FT WP+ GVP + + I+F V +Q + PI VHCSAGVGRTG FI +
Sbjct: 1390 VRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSI 1449
Query: 1255 LIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRS 1301
++ ++ E VD++ V LR RP MVQTEDQY F + L+ + S
Sbjct: 1450 VLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS 1496
Score = 46.6 bits (109), Expect = 2e-04
Identities = 70/306 (22%), Positives = 115/306 (37%), Gaps = 32/306 (10%)
Query: 378 SATSLTLIWKVSDNESSSNY--TYKIHVAGETDSSNLNVSEPRAVIPGLRSSTFYNITVC 435
+ATS+TL W + E S Y +K + E V+ R + GL + Y V
Sbjct: 332 TATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVV 391
Query: 436 PVLGDIEGTPG--FLQVHTPPVPVS---DFRVTVVSTTEIGLAWSSHDAES--------- 481
V G P L + P S D + ++S+T I + W + +
Sbjct: 392 AVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVY 451
Query: 482 FQMHITQEGAGNSRVEITTNQSIIIGGLFPGTKY-----CFEIVPKGPNGTEGASRTVCN 536
+ M TQ + + +Q IG L P Y F + GP ++ + +
Sbjct: 452 YTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSD--IQVITQ 509
Query: 537 RTVPSAVFDIHVVYVTTTEMWLDWKSPDGASEYVYHLVI-ESKHGSNHTSTYDKAIT--L 593
VP + + T + L W P + Y LV + +HG T + + L
Sbjct: 510 TGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRL 569
Query: 594 QGLIPGTLYNITISPEVDHVWGDPNS--TAQYTRPSNVSNIDV-STNTTAATLSW---QN 647
QGL P +LY ++ G + +A+ + N V + T+ LSW +N
Sbjct: 570 QGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSMFAKNFHVKAVMKTSVLLSWEIPEN 629
Query: 648 FDDASP 653
++ A P
Sbjct: 630 YNSAMP 635
Score = 45.8 bits (107), Expect = 3e-04
Identities = 55/260 (21%), Positives = 102/260 (39%), Gaps = 27/260 (10%)
Query: 328 TEVLLVGLEPGTRYNATVYS--QAANGTEGQPQAIEFRTNAIQVF--DVTAVNISATSLT 383
T + GL P + Y V + G +P + A DV A +S+T++
Sbjct: 373 TRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTIL 432
Query: 384 LIWKVSDNESSSNYTYKIHVAGETDSS-----NLNVSEPRAVIPG---------LRSSTF 429
+ WK + + Y+++ + NV++ + G ++ F
Sbjct: 433 VQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAF 492
Query: 430 YNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDAESFQ----MH 485
+I P+ DI+ Q P P++ F+ S T I L+W+ +++ ++
Sbjct: 493 TSIGDGPLSSDIQV---ITQTGVPGQPLN-FKAEPESETSILLSWTPPRSDTIANYELVY 548
Query: 486 ITQEGAGNSRVEITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTVPSA-VF 544
E R+ I S + GL P + Y F + + P G ++ + RT+ S
Sbjct: 549 KDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSMFAK 608
Query: 545 DIHVVYVTTTEMWLDWKSPD 564
+ HV V T + L W+ P+
Sbjct: 609 NFHVKAVMKTSVLLSWEIPE 628
>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform 3
precursor [Homo sapiens]
Length = 1903
Score = 269 bits (688), Expect = 1e-71
Identities = 324/1330 (24%), Positives = 544/1330 (40%), Gaps = 197/1330 (14%)
Query: 119 PSPVFDIKAVSISPTNVILTWKSNDTAASEYKYVVKHKMENE----KTITVVHQPWCNIT 174
P P + T++ LTW S + Y Y+++HK +N K I V ++
Sbjct: 323 PKPPGTPVVTESTATSITLTWDSGNPEPVSY-YIIQHKPKNSEELYKEIDGVATTRYSVA 381
Query: 175 GLRPATSYVFSITPGIGNETWGDPR--VIKVITEPIPVS---DLRVALTGVRKAALSWSN 229
GL P + Y F + + N G P V+ +E P S D++ + + W
Sbjct: 382 GLSPYSDYEFRVV-AVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKE 440
Query: 230 G---NGTASCRVLLESIGSHEELTQDSRLQVNISGLKPGVQYNINPYLLQSNKTKGDPLG 286
NG + ++ + + ++ ++ N++ + N+ P S K
Sbjct: 441 PEEPNGQIQGYRVYYTMDPTQHV--NNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSI 498
Query: 287 TEGGLDASNTERSRAGSPTAPVHDES--------LVGPVDPSS---------------GQ 323
+G L + ++ G P P++ ++ L+ P S G+
Sbjct: 499 GDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGE 558
Query: 324 QSR-----DTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQVF----DVTA 374
+ R T L GL+P + Y + +++ G I RT + D++
Sbjct: 559 EQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISC 618
Query: 375 VNISATSLTLIWKVSDNESSSN----YTYKIH-VAGETDSSNLNVSEP----RAVIPGLR 425
+ S+TS+ + W+ E + Y+ K V GE D + + P + ++ L
Sbjct: 619 TSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLE 678
Query: 426 SSTFYNITVCPVLGDIEGTPGFLQV------HTPPVPVSDFRVTVVSTTEIGLAWSSH-- 477
T Y ITV D+ P L V P P V V++T + ++W S
Sbjct: 679 KWTEYRITVTAHT-DVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVP 737
Query: 478 -----DAESFQMHITQEGAGNSR-------VEITTNQSIIIGGLFPGTKYCFEIVPKGPN 525
+Q+H + G + V + Q +II GL P T Y +
Sbjct: 738 NKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQDMIISGLQPETSYSLTVTAYTTK 797
Query: 526 GTEGASRTVCNRTVPSAVFDIHVVYVTTTEM---WLDWKSPDGASEYV--YHLVIESKHG 580
G S+ T + +V + T+M + W P + Y L K
Sbjct: 798 GDGARSKPKLVSTTGAVPGKPRLV-INHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDM 856
Query: 581 SNHT----STYDKAITLQGLIPGTLYNITISPEVDHVWGDPNSTAQYTRPSNV-----SN 631
T S + T + G Y +S +G+ + + P V N
Sbjct: 857 EPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGE-EMVKEISIPEEVPTGFPQN 915
Query: 632 I-DVSTNTTAATLSWQNFDDASPTYSYCLLIEKAGNSSNATQVVTDIGI----------- 679
+ T +T+ LSWQ +L E+ G + T + DI I
Sbjct: 916 LHSEGTTSTSVQLSWQP----------PVLAERNGIITKYTLLYRDINIPLLPMEQLIVP 965
Query: 680 --TDATVTELIPGSSYTVEIFAQVGDGIKSLEPGR--KSFCTDPASMASFDCEVVPKEPA 735
T T+T L P ++Y V++ A G P ++ D +F + V K
Sbjct: 966 ADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSV 1025
Query: 736 LVLKWTCPPGANAGFELEVSSGAWNNATHLESCSSENGTEYRTEVTYLNFSTSYNISITT 795
L L W P N+ ++ +++ +E +G + + L SY+ +T
Sbjct: 1026 L-LSWEIPENYNSAMPFKI---LYDDGKMVEEV---DGRATQKLIVNLKPEKSYSFVLTN 1078
Query: 796 ---VSCGKMAAPTRNTCTTGITDPPPPDGSPNITSVSHNSVKVKFSGFEASHGPIKAYAV 852
+ G T T + P G N+ + + V+ A+ IK Y +
Sbjct: 1079 RGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGM----ITVQLPEVPANEN-IKGYYI 1133
Query: 853 IL-----TTGEAGHPSADVLKYTYEDFKKGASDTY--VTYLIRTEEKGRSQSLSEVLKYE 905
I+ + G+ P + ++ K S + Y E K + +VL E
Sbjct: 1134 IIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLPTE 1193
Query: 906 IDVGNESTTLGYYNGKLEPLGSYRACVAGFTNITFHPQNKGLIDGAESYV-SFSRYSD-A 963
+G++ G+ N +L+ Y V +++ AES + + S YSD
Sbjct: 1194 FTLGDDKHYGGFTNKQLQSGQEYVFFVLA------------VMEHAESKMYATSPYSDPV 1241
Query: 964 VSLPQDPGVIC----------GAVFGCIFGALVIVTVGGFIFWRKKRKDAKNNEVSFSQI 1013
VS+ DP I G V +F +++ + + +++KR ++ + + S
Sbjct: 1242 VSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAI---LLYKRKRAESDSRKSSIPNN 1298
Query: 1014 K------PKKSKLIRVENFEA----------------YFKKQQADSNCGFAEEYEDLKLV 1051
K P +R NF+ + ++ +A+ N F++EYE +
Sbjct: 1299 KEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESID-P 1357
Query: 1052 GISQPKYAAELAENRGKNRYNNVLPYDISRVKLS-VQTHSTDDYINANYMPGYHSKKDFI 1110
G + L N+ KNRY NV+ YD SRV LS ++ DY+NANY+ GY + +I
Sbjct: 1358 GQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYI 1417
Query: 1111 ATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTS 1170
ATQG LP T DFWRM+WE+ ++M+TK E+ R KC++YWPS+ + +G + V +
Sbjct: 1418 ATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLD 1477
Query: 1171 EIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSP 1230
+ L + +R F + +SE +RQF FT+WPDHGVP+ + F +R +P
Sbjct: 1478 TVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAF---LRRVKTCNP 1534
Query: 1231 PES-PILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYV 1289
P++ P++VHCSAGVGRTG FI ID ++ +I++E TVD+YG V +R R MVQTEDQY+
Sbjct: 1535 PDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYI 1594
Query: 1290 FLNQCVLDIV 1299
F++ +L+ V
Sbjct: 1595 FIHDALLEAV 1604
Score = 209 bits (533), Expect = 1e-53
Identities = 111/287 (38%), Positives = 168/287 (58%), Gaps = 6/287 (2%)
Query: 1021 IRVENFEAYFKK----QQADSNCGFAEEYEDLKLVGISQPKY-AAELAENRGKNRYNNVL 1075
+ N AY +K + ++ G E++ L ++ +A L N+ KNR N++
Sbjct: 1611 VPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIM 1670
Query: 1076 PYDISRVKLS-VQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYA 1134
PY+ +RV L ++ DYINA+++ GY +K +IATQGPL T +DFWRM+WE N
Sbjct: 1671 PYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTI 1730
Query: 1135 IIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHP 1194
++MLTK E GR KC +YWP++++ Y V +E +P++ +R+F V + + +S
Sbjct: 1731 VVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRT 1790
Query: 1195 LRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDR 1254
+RQF FT WP+ GVP + + I+F V +Q + PI VHCSAGVGRTG FI +
Sbjct: 1791 VRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSI 1850
Query: 1255 LIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRS 1301
++ ++ E VD++ V LR RP MVQTEDQY F + L+ + S
Sbjct: 1851 VLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS 1897
Score = 65.9 bits (159), Expect = 3e-10
Identities = 103/472 (21%), Positives = 173/472 (36%), Gaps = 39/472 (8%)
Query: 424 LRSSTFYNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDAESFQ 483
+R S Y LG IE + V P P VT + T I L W S + E
Sbjct: 294 VRQSANYTCVAMSTLGVIEAIAQ-ITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVS 352
Query: 484 MHITQEGAGNS-----RVEITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRT 538
+I Q NS ++ + GL P + Y F +V G S V +T
Sbjct: 353 YYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQT 412
Query: 539 ----VPSAVFDIHVVYVTTTEMWLDWKSPDGASEY-----VYHLVIESKHGSN---HTST 586
SA D+ +++T + + WK P+ + VY+ + ++H +N H
Sbjct: 413 SEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVA 472
Query: 587 YDKAITLQGLIPGTLYNITISPEVDHVWGDPNSTAQYTRPSNVSNIDVS-----TNTTAA 641
+ T+ L+P Y++ + G +S Q + V ++ + T+
Sbjct: 473 DSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSI 532
Query: 642 TLSWQNFDDASPTYSYCLLIEKAGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQ- 700
LSW S T + L+ K G ++ + G T + L P S Y + A+
Sbjct: 533 LLSWT--PPRSDTIANYELVYKDGEHGEEQRITIEPG-TSYRLQGLKPNSLYYFRLAARS 589
Query: 701 -VGDGIKSLEPGRKSFCTDPASMASFDCEVVPKEPALVLKWTCPP-----GANAGFELEV 754
G G + E ++ + P++ P ++++ W PP G + ++
Sbjct: 590 PQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKY 649
Query: 755 SS-GAWNNATHLESCSSENGTEYRTEVTYLNFSTSYNISITT-VSCGKMAAPTRNTCTTG 812
++ ++ H + T+Y E L T Y I++T G T
Sbjct: 650 TAVDGEDDKPHEILGIPSDTTKYLLE--QLEKWTEYRITVTAHTDVGPGPESLSVLIRTN 707
Query: 813 ITDPPPPDGSPNITSVSHNSVKVKFSG--FEASHGPIKAYAVILTTGEAGHP 862
P P + +V+ SVKV + HG I+ Y V E G P
Sbjct: 708 EDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEP 759
>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
precursor [Homo sapiens]
Length = 1912
Score = 266 bits (681), Expect = 8e-71
Identities = 324/1339 (24%), Positives = 544/1339 (40%), Gaps = 206/1339 (15%)
Query: 119 PSPVFDIKAVSISPTNVILTWKSNDTAASEYKYVVKHKMENE----KTITVVHQPWCNIT 174
P P + T++ LTW S + Y Y+++HK +N K I V ++
Sbjct: 323 PKPPGTPVVTESTATSITLTWDSGNPEPVSY-YIIQHKPKNSEELYKEIDGVATTRYSVA 381
Query: 175 GLRPATSYVFSITPGIGNETWGDPR--VIKVITEPIPVS---DLRVALTGVRKAALSWSN 229
GL P + Y F + + N G P V+ +E P S D++ + + W
Sbjct: 382 GLSPYSDYEFRVV-AVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKE 440
Query: 230 G---NGTASCRVLLESIGSHEELTQDSRLQVNISGLKPGVQYNINPYLLQSNKTKGDPLG 286
NG + ++ + + ++ ++ N++ + N+ P S K
Sbjct: 441 PEEPNGQIQGYRVYYTMDPTQHV--NNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSI 498
Query: 287 TEGGLDASNTERSRAGSPTAPVHDES--------LVGPVDPSS---------------GQ 323
+G L + ++ G P P++ ++ L+ P S G+
Sbjct: 499 GDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGE 558
Query: 324 QSR-----DTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQVF----DVTA 374
+ R T L GL+P + Y + +++ G I RT + D++
Sbjct: 559 EQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISC 618
Query: 375 VNISATSLTLIWKVSDNESSSN----YTYKIH-VAGETDSSNLNVSEP----RAVIPGLR 425
+ S+TS+ + W+ E + Y+ K V GE D + + P + ++ L
Sbjct: 619 TSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLE 678
Query: 426 SSTFYNITVCPVLGDIEGTPGFLQV------HTPPVPVSDFRVTVVSTTEIGLAWSSH-- 477
T Y ITV D+ P L V P P V V++T + ++W S
Sbjct: 679 KWTEYRITVTAHT-DVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVP 737
Query: 478 -----DAESFQMHITQEGAGNSR----------------VEITTNQSIIIGGLFPGTKYC 516
+Q+H + G + + TT +II GL P T Y
Sbjct: 738 NKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYS 797
Query: 517 FEIVPKGPNGTEGASRTVCNRTVPSAVFDIHVVYVTTTEM---WLDWKSPDGASEYV--Y 571
+ G S+ T + +V + T+M + W P + Y
Sbjct: 798 LTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLV-INHTQMNTALIQWHPPVDTFGPLQGY 856
Query: 572 HLVIESKHGSNHT----STYDKAITLQGLIPGTLYNITISPEVDHVWGDPNSTAQYTRPS 627
L K T S + T + G Y +S +G+ + + P
Sbjct: 857 RLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGE-EMVKEISIPE 915
Query: 628 NV-----SNI-DVSTNTTAATLSWQNFDDASPTYSYCLLIEKAGNSSNATQVVTDIGI-- 679
V N+ T +T+ LSWQ +L E+ G + T + DI I
Sbjct: 916 EVPTGFPQNLHSEGTTSTSVQLSWQP----------PVLAERNGIITKYTLLYRDINIPL 965
Query: 680 -----------TDATVTELIPGSSYTVEIFAQVGDGIKSLEPGR--KSFCTDPASMASFD 726
T T+T L P ++Y V++ A G P ++ D +F
Sbjct: 966 LPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFH 1025
Query: 727 CEVVPKEPALVLKWTCPPGANAGFELEVSSGAWNNATHLESCSSENGTEYRTEVTYLNFS 786
+ V K L L W P N+ ++ +++ +E +G + + L
Sbjct: 1026 VKAVMKTSVL-LSWEIPENYNSAMPFKI---LYDDGKMVEEV---DGRATQKLIVNLKPE 1078
Query: 787 TSYNISITT---VSCGKMAAPTRNTCTTGITDPPPPDGSPNITSVSHNSVKVKFSGFEAS 843
SY+ +T + G T T + P G N+ + + V+ A+
Sbjct: 1079 KSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGM----ITVQLPEVPAN 1134
Query: 844 HGPIKAYAVIL-----TTGEAGHPSADVLKYTYEDFKKGASDTY--VTYLIRTEEKGRSQ 896
IK Y +I+ + G+ P + ++ K S + Y E K
Sbjct: 1135 EN-IKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIA 1193
Query: 897 SLSEVLKYEIDVGNESTTLGYYNGKLEPLGSYRACVAGFTNITFHPQNKGLIDGAESYV- 955
+ +VL E +G++ G+ N +L+ Y V +++ AES +
Sbjct: 1194 AHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLA------------VMEHAESKMY 1241
Query: 956 SFSRYSD-AVSLPQDPGVIC----------GAVFGCIFGALVIVTVGGFIFWRKKRKDAK 1004
+ S YSD VS+ DP I G V +F +++ + + +++KR ++
Sbjct: 1242 ATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAI---LLYKRKRAESD 1298
Query: 1005 NNEVSFSQIK------PKKSKLIRVENFEA----------------YFKKQQADSNCGFA 1042
+ + S K P +R NF+ + ++ +A+ N F+
Sbjct: 1299 SRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFS 1358
Query: 1043 EEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLS-VQTHSTDDYINANYMP 1101
+EYE + G + L N+ KNRY NV+ YD SRV LS ++ DY+NANY+
Sbjct: 1359 QEYESID-PGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYID 1417
Query: 1102 GYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDY 1161
GY + +IATQG LP T DFWRM+WE+ ++M+TK E+ R KC++YWPS+ + +
Sbjct: 1418 GYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETH 1477
Query: 1162 GDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYL 1221
G + V + + L + +R F + +SE +RQF FT+WPDHGVP+ + F
Sbjct: 1478 GLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAF--- 1534
Query: 1222 VRDYMKQSPPES-PILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPL 1280
+R +PP++ P++VHCSAGVGRTG FI ID ++ +I++E TVD+YG V +R R
Sbjct: 1535 LRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNY 1594
Query: 1281 MVQTEDQYVFLNQCVLDIV 1299
MVQTEDQY+F++ +L+ V
Sbjct: 1595 MVQTEDQYIFIHDALLEAV 1613
Score = 209 bits (533), Expect = 1e-53
Identities = 111/287 (38%), Positives = 168/287 (58%), Gaps = 6/287 (2%)
Query: 1021 IRVENFEAYFKK----QQADSNCGFAEEYEDLKLVGISQPKY-AAELAENRGKNRYNNVL 1075
+ N AY +K + ++ G E++ L ++ +A L N+ KNR N++
Sbjct: 1620 VPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIM 1679
Query: 1076 PYDISRVKLS-VQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYA 1134
PY+ +RV L ++ DYINA+++ GY +K +IATQGPL T +DFWRM+WE N
Sbjct: 1680 PYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTI 1739
Query: 1135 IIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHP 1194
++MLTK E GR KC +YWP++++ Y V +E +P++ +R+F V + + +S
Sbjct: 1740 VVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRT 1799
Query: 1195 LRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDR 1254
+RQF FT WP+ GVP + + I+F V +Q + PI VHCSAGVGRTG FI +
Sbjct: 1800 VRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSI 1859
Query: 1255 LIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRS 1301
++ ++ E VD++ V LR RP MVQTEDQY F + L+ + S
Sbjct: 1860 VLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS 1906
Score = 65.9 bits (159), Expect = 3e-10
Identities = 103/472 (21%), Positives = 173/472 (36%), Gaps = 39/472 (8%)
Query: 424 LRSSTFYNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDAESFQ 483
+R S Y LG IE + V P P VT + T I L W S + E
Sbjct: 294 VRQSANYTCVAMSTLGVIEAIAQ-ITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVS 352
Query: 484 MHITQEGAGNS-----RVEITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRT 538
+I Q NS ++ + GL P + Y F +V G S V +T
Sbjct: 353 YYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQT 412
Query: 539 ----VPSAVFDIHVVYVTTTEMWLDWKSPDGASEY-----VYHLVIESKHGSN---HTST 586
SA D+ +++T + + WK P+ + VY+ + ++H +N H
Sbjct: 413 SEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVA 472
Query: 587 YDKAITLQGLIPGTLYNITISPEVDHVWGDPNSTAQYTRPSNVSNIDVS-----TNTTAA 641
+ T+ L+P Y++ + G +S Q + V ++ + T+
Sbjct: 473 DSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSI 532
Query: 642 TLSWQNFDDASPTYSYCLLIEKAGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQ- 700
LSW S T + L+ K G ++ + G T + L P S Y + A+
Sbjct: 533 LLSWT--PPRSDTIANYELVYKDGEHGEEQRITIEPG-TSYRLQGLKPNSLYYFRLAARS 589
Query: 701 -VGDGIKSLEPGRKSFCTDPASMASFDCEVVPKEPALVLKWTCPP-----GANAGFELEV 754
G G + E ++ + P++ P ++++ W PP G + ++
Sbjct: 590 PQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKY 649
Query: 755 SS-GAWNNATHLESCSSENGTEYRTEVTYLNFSTSYNISITT-VSCGKMAAPTRNTCTTG 812
++ ++ H + T+Y E L T Y I++T G T
Sbjct: 650 TAVDGEDDKPHEILGIPSDTTKYLLE--QLEKWTEYRITVTAHTDVGPGPESLSVLIRTN 707
Query: 813 ITDPPPPDGSPNITSVSHNSVKVKFSG--FEASHGPIKAYAVILTTGEAGHP 862
P P + +V+ SVKV + HG I+ Y V E G P
Sbjct: 708 EDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEP 759
>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform 2
precursor [Homo sapiens]
Length = 1899
Score = 266 bits (681), Expect = 8e-71
Identities = 324/1339 (24%), Positives = 544/1339 (40%), Gaps = 206/1339 (15%)
Query: 119 PSPVFDIKAVSISPTNVILTWKSNDTAASEYKYVVKHKMENE----KTITVVHQPWCNIT 174
P P + T++ LTW S + Y Y+++HK +N K I V ++
Sbjct: 310 PKPPGTPVVTESTATSITLTWDSGNPEPVSY-YIIQHKPKNSEELYKEIDGVATTRYSVA 368
Query: 175 GLRPATSYVFSITPGIGNETWGDPR--VIKVITEPIPVS---DLRVALTGVRKAALSWSN 229
GL P + Y F + + N G P V+ +E P S D++ + + W
Sbjct: 369 GLSPYSDYEFRVV-AVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKE 427
Query: 230 G---NGTASCRVLLESIGSHEELTQDSRLQVNISGLKPGVQYNINPYLLQSNKTKGDPLG 286
NG + ++ + + ++ ++ N++ + N+ P S K
Sbjct: 428 PEEPNGQIQGYRVYYTMDPTQHV--NNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSI 485
Query: 287 TEGGLDASNTERSRAGSPTAPVHDES--------LVGPVDPSS---------------GQ 323
+G L + ++ G P P++ ++ L+ P S G+
Sbjct: 486 GDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGE 545
Query: 324 QSR-----DTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQVF----DVTA 374
+ R T L GL+P + Y + +++ G I RT + D++
Sbjct: 546 EQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISC 605
Query: 375 VNISATSLTLIWKVSDNESSSN----YTYKIH-VAGETDSSNLNVSEP----RAVIPGLR 425
+ S+TS+ + W+ E + Y+ K V GE D + + P + ++ L
Sbjct: 606 TSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLE 665
Query: 426 SSTFYNITVCPVLGDIEGTPGFLQV------HTPPVPVSDFRVTVVSTTEIGLAWSSH-- 477
T Y ITV D+ P L V P P V V++T + ++W S
Sbjct: 666 KWTEYRITVTAHT-DVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVP 724
Query: 478 -----DAESFQMHITQEGAGNSR----------------VEITTNQSIIIGGLFPGTKYC 516
+Q+H + G + + TT +II GL P T Y
Sbjct: 725 NKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYS 784
Query: 517 FEIVPKGPNGTEGASRTVCNRTVPSAVFDIHVVYVTTTEM---WLDWKSPDGASEYV--Y 571
+ G S+ T + +V + T+M + W P + Y
Sbjct: 785 LTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLV-INHTQMNTALIQWHPPVDTFGPLQGY 843
Query: 572 HLVIESKHGSNHT----STYDKAITLQGLIPGTLYNITISPEVDHVWGDPNSTAQYTRPS 627
L K T S + T + G Y +S +G+ + + P
Sbjct: 844 RLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGE-EMVKEISIPE 902
Query: 628 NV-----SNI-DVSTNTTAATLSWQNFDDASPTYSYCLLIEKAGNSSNATQVVTDIGI-- 679
V N+ T +T+ LSWQ +L E+ G + T + DI I
Sbjct: 903 EVPTGFPQNLHSEGTTSTSVQLSWQP----------PVLAERNGIITKYTLLYRDINIPL 952
Query: 680 -----------TDATVTELIPGSSYTVEIFAQVGDGIKSLEPGR--KSFCTDPASMASFD 726
T T+T L P ++Y V++ A G P ++ D +F
Sbjct: 953 LPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFH 1012
Query: 727 CEVVPKEPALVLKWTCPPGANAGFELEVSSGAWNNATHLESCSSENGTEYRTEVTYLNFS 786
+ V K L L W P N+ ++ +++ +E +G + + L
Sbjct: 1013 VKAVMKTSVL-LSWEIPENYNSAMPFKI---LYDDGKMVEEV---DGRATQKLIVNLKPE 1065
Query: 787 TSYNISITT---VSCGKMAAPTRNTCTTGITDPPPPDGSPNITSVSHNSVKVKFSGFEAS 843
SY+ +T + G T T + P G N+ + + V+ A+
Sbjct: 1066 KSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGM----ITVQLPEVPAN 1121
Query: 844 HGPIKAYAVIL-----TTGEAGHPSADVLKYTYEDFKKGASDTY--VTYLIRTEEKGRSQ 896
IK Y +I+ + G+ P + ++ K S + Y E K
Sbjct: 1122 EN-IKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIA 1180
Query: 897 SLSEVLKYEIDVGNESTTLGYYNGKLEPLGSYRACVAGFTNITFHPQNKGLIDGAESYV- 955
+ +VL E +G++ G+ N +L+ Y V +++ AES +
Sbjct: 1181 AHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLA------------VMEHAESKMY 1228
Query: 956 SFSRYSD-AVSLPQDPGVIC----------GAVFGCIFGALVIVTVGGFIFWRKKRKDAK 1004
+ S YSD VS+ DP I G V +F +++ + + +++KR ++
Sbjct: 1229 ATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAI---LLYKRKRAESD 1285
Query: 1005 NNEVSFSQIK------PKKSKLIRVENFEA----------------YFKKQQADSNCGFA 1042
+ + S K P +R NF+ + ++ +A+ N F+
Sbjct: 1286 SRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFS 1345
Query: 1043 EEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLS-VQTHSTDDYINANYMP 1101
+EYE + G + L N+ KNRY NV+ YD SRV LS ++ DY+NANY+
Sbjct: 1346 QEYESID-PGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYID 1404
Query: 1102 GYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDY 1161
GY + +IATQG LP T DFWRM+WE+ ++M+TK E+ R KC++YWPS+ + +
Sbjct: 1405 GYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETH 1464
Query: 1162 GDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYL 1221
G + V + + L + +R F + +SE +RQF FT+WPDHGVP+ + F
Sbjct: 1465 GLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAF--- 1521
Query: 1222 VRDYMKQSPPES-PILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPL 1280
+R +PP++ P++VHCSAGVGRTG FI ID ++ +I++E TVD+YG V +R R
Sbjct: 1522 LRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNY 1581
Query: 1281 MVQTEDQYVFLNQCVLDIV 1299
MVQTEDQY+F++ +L+ V
Sbjct: 1582 MVQTEDQYIFIHDALLEAV 1600
Score = 209 bits (533), Expect = 1e-53
Identities = 111/287 (38%), Positives = 168/287 (58%), Gaps = 6/287 (2%)
Query: 1021 IRVENFEAYFKK----QQADSNCGFAEEYEDLKLVGISQPKY-AAELAENRGKNRYNNVL 1075
+ N AY +K + ++ G E++ L ++ +A L N+ KNR N++
Sbjct: 1607 VPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIM 1666
Query: 1076 PYDISRVKLS-VQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYA 1134
PY+ +RV L ++ DYINA+++ GY +K +IATQGPL T +DFWRM+WE N
Sbjct: 1667 PYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTI 1726
Query: 1135 IIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHP 1194
++MLTK E GR KC +YWP++++ Y V +E +P++ +R+F V + + +S
Sbjct: 1727 VVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRT 1786
Query: 1195 LRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDR 1254
+RQF FT WP+ GVP + + I+F V +Q + PI VHCSAGVGRTG FI +
Sbjct: 1787 VRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSI 1846
Query: 1255 LIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRS 1301
++ ++ E VD++ V LR RP MVQTEDQY F + L+ + S
Sbjct: 1847 VLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS 1893
Score = 65.9 bits (159), Expect = 3e-10
Identities = 103/472 (21%), Positives = 173/472 (36%), Gaps = 39/472 (8%)
Query: 424 LRSSTFYNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDAESFQ 483
+R S Y LG IE + V P P VT + T I L W S + E
Sbjct: 281 VRQSANYTCVAMSTLGVIEAIAQ-ITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVS 339
Query: 484 MHITQEGAGNS-----RVEITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRT 538
+I Q NS ++ + GL P + Y F +V G S V +T
Sbjct: 340 YYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQT 399
Query: 539 ----VPSAVFDIHVVYVTTTEMWLDWKSPDGASEY-----VYHLVIESKHGSN---HTST 586
SA D+ +++T + + WK P+ + VY+ + ++H +N H
Sbjct: 400 SEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVA 459
Query: 587 YDKAITLQGLIPGTLYNITISPEVDHVWGDPNSTAQYTRPSNVSNIDVS-----TNTTAA 641
+ T+ L+P Y++ + G +S Q + V ++ + T+
Sbjct: 460 DSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSI 519
Query: 642 TLSWQNFDDASPTYSYCLLIEKAGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQ- 700
LSW S T + L+ K G ++ + G T + L P S Y + A+
Sbjct: 520 LLSWT--PPRSDTIANYELVYKDGEHGEEQRITIEPG-TSYRLQGLKPNSLYYFRLAARS 576
Query: 701 -VGDGIKSLEPGRKSFCTDPASMASFDCEVVPKEPALVLKWTCPP-----GANAGFELEV 754
G G + E ++ + P++ P ++++ W PP G + ++
Sbjct: 577 PQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKY 636
Query: 755 SS-GAWNNATHLESCSSENGTEYRTEVTYLNFSTSYNISITT-VSCGKMAAPTRNTCTTG 812
++ ++ H + T+Y E L T Y I++T G T
Sbjct: 637 TAVDGEDDKPHEILGIPSDTTKYLLE--QLEKWTEYRITVTAHTDVGPGPESLSVLIRTN 694
Query: 813 ITDPPPPDGSPNITSVSHNSVKVKFSG--FEASHGPIKAYAVILTTGEAGHP 862
P P + +V+ SVKV + HG I+ Y V E G P
Sbjct: 695 EDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEP 746
>gi|104487611 protein tyrosine phosphatase, receptor type, sigma
isoform 4 precursor [Homo sapiens]
Length = 1505
Score = 258 bits (659), Expect = 3e-68
Identities = 259/982 (26%), Positives = 411/982 (41%), Gaps = 141/982 (14%)
Query: 407 TDSSNLNVSEPRAVIPGLRSSTFYNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVS 466
T ++ V + ++ S Y LG IE P P + VT +
Sbjct: 277 TPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPM-VTENT 335
Query: 467 TTEIGLAWSSHDAESFQMHI------TQEGAGNSRVEITTNQSIIIGGLFPGTKYCFEIV 520
T I + W S + + ++ +Q+G + +ITT + IGGL P ++Y +
Sbjct: 336 ATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTR-YSIGGLSPNSEYEIWVS 394
Query: 521 PKGPNGTEGASRTVCNRT----VPSAVFDIHVVYVTTTEMWLDWKSPDGASE----YVYH 572
G S +V RT SA ++ ++ T M + W+ P + Y +
Sbjct: 395 AVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVY 454
Query: 573 LVIESKH--GSNHTSTYDKAI--TLQGLIPGTLYNITI---SPEVDHVWGDPNST-AQYT 624
+E +H G+ D ++ T+ L+ Y + + + D DP Q
Sbjct: 455 YTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQG 514
Query: 625 RPSNVSNIDVSTNT-TAATLSWQNFDDASPTYSYCLLIEKAGNSSNATQVVTDIGITDAT 683
P N+ + T+ TLSW S Y LL + + + T
Sbjct: 515 VPGQPMNLRAEARSETSITLSWSPPRQES-IIKYELLFREGDHGREVGRTFDPT--TSYV 571
Query: 684 VTELIPGSSYTVEIFAQVGDGIKSLEPGRKSFCTDPASMASFDCEVVPKEPALVLKWTCP 743
V +L P + Y + A+ G+ + P + S +F +++ K L L W P
Sbjct: 572 VEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSISPKNFKVKMIMKTSVL-LSWEFP 630
Query: 744 PGANAGFELEVSSGAWNNATHLESCSSENGTEYRTEVTYLNFSTSYNISITTVSCGKMAA 803
N+ ++ +N T +G + +T+L T YN +T + G
Sbjct: 631 DNYNSPTPYKIQ---YNGLT-----LDVDGRTTKKLITHLKPHTFYNFVLT--NRGSSLG 680
Query: 804 PTRNTCTTGITDPPPPDGSPNITSVSHNSVKVKFSGF-------EASHGPIKAYAVILTT 856
+ T T T +G P++ K GF S P+++Y +++
Sbjct: 681 GLQQTVTAW-TAFNLLNGKPSVAP------KPDADGFIMVYLPDGQSPVPVQSYFIVMVP 733
Query: 857 GEAGHPSADVLKYTYEDFKKGASDTYVTYLIRTEEKGRSQSLSEVLKYEIDVGNESTTLG 916
+K ++T L E+ L E+++ D+
Sbjct: 734 -----------------LRKSRGGQFLTPLGSPED----MDLEELIQ---DISRLQRRSL 769
Query: 917 YYNGKLEPLGSYRACVAGFTNITFHP---------QNKGLIDGAESYVSF---------- 957
++ +LE Y A TFHP N+GL G YV F
Sbjct: 770 RHSRQLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPG-HRYVLFVLAVLQKSEP 828
Query: 958 ----SRYSDAVSL--PQDPGVICGA-----VFGCIFGALVIVTVGGFIFWRKKRKDAKN- 1005
S +SD L P ++ G V G + + I+ + I K + D+K
Sbjct: 829 TFAASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRK 888
Query: 1006 ----------NEVSFSQIKPKKSKLIRVENFEA----------------YFKKQQADSNC 1039
N + PK +R NF+ + ++ +A+ +
Sbjct: 889 DSEPRTKCLLNNADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSL 948
Query: 1040 GFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLS-VQTHSTDDYINAN 1098
++EYE + G + L N+ KNRY NV+ YD SRV L ++ DYINAN
Sbjct: 949 KLSQEYESID-PGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINAN 1007
Query: 1099 YMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQA 1158
Y+ GY + +IATQGPLP T DFWRMVWE+ I+M+T+ E+ R KC++YWP++
Sbjct: 1008 YVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGT 1067
Query: 1159 QDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINF 1218
+ YG I V + I L + +R F++ +SE +RQF FT+WPDHGVP+ + F
Sbjct: 1068 ETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAF 1127
Query: 1219 RYLVRDYMKQSPPES-PILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMH 1277
+R +PP++ PI+VHCSAGVGRTG FI ID ++ +I+ E TVDVYG V +R
Sbjct: 1128 ---LRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQ 1184
Query: 1278 RPLMVQTEDQYVFLNQCVLDIV 1299
R MVQTEDQY F+++ +L+ V
Sbjct: 1185 RNYMVQTEDQYSFIHEALLEAV 1206
Score = 210 bits (534), Expect = 8e-54
Identities = 104/244 (42%), Positives = 152/244 (62%), Gaps = 1/244 (0%)
Query: 1059 AAELAENRGKNRYNNVLPYDISRVKLS-VQTHSTDDYINANYMPGYHSKKDFIATQGPLP 1117
+A L N+ KNR N++PY+ +RV L ++ DYINA+++ GY +K +IATQGPL
Sbjct: 1256 SANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLA 1315
Query: 1118 NTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEW 1177
T +DFWRM+WE N ++MLTK E GR KC +YWP++++ Y V +E +P++
Sbjct: 1316 ETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQY 1375
Query: 1178 TIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILV 1237
+R+F V + + +S +RQF FT WP+ GVP + + I+F V +Q + PI V
Sbjct: 1376 ILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISV 1435
Query: 1238 HCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLD 1297
HCSAGVGRTG FI + ++ ++ E VD++ V LR RP MVQTED+Y F Q L+
Sbjct: 1436 HCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALE 1495
Query: 1298 IVRS 1301
+ S
Sbjct: 1496 YLGS 1499
Score = 46.6 bits (109), Expect = 2e-04
Identities = 75/318 (23%), Positives = 120/318 (37%), Gaps = 24/318 (7%)
Query: 328 TEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTN----AIQVFDVTAVNISATSLT 383
T + GL P + Y V + + G +++ RT A +V A +SAT++
Sbjct: 376 TRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMI 435
Query: 384 LIWKVSDNESSSNYTYKI-------HVAGETDSSNLNVSEPRAVIPGLRSSTFYNITVCP 436
+ W+ + Y++ H G N++ S V L T Y + V
Sbjct: 436 VQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDET-YTVRVLA 494
Query: 437 VLGDIEGTPGF-LQVHTP---PVPVSDFRVTVVSTTEIGLAWSSHDAESFQMH--ITQEG 490
+G +QV T P + R S T I L+WS ES + + +EG
Sbjct: 495 FTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREG 554
Query: 491 AGNSRVEITTNQ--SIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTVPS-AVFDIH 547
V T + S ++ L P T+Y F + + P G + V RT+ S + +
Sbjct: 555 DHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSISPKNFK 614
Query: 548 VVYVTTTEMWLDWKSPDG-ASEYVYHLVIESKHGSNHTSTYDKAITLQGLIPGTLYNITI 606
V + T + L W+ PD S Y + T K IT L P T YN +
Sbjct: 615 VKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKKLIT--HLKPHTFYNFVL 672
Query: 607 SPEVDHVWGDPNSTAQYT 624
+ + G + +T
Sbjct: 673 TNRGSSLGGLQQTVTAWT 690
>gi|104487295 protein tyrosine phosphatase, receptor type, sigma
isoform 3 precursor [Homo sapiens]
Length = 1501
Score = 258 bits (659), Expect = 3e-68
Identities = 259/982 (26%), Positives = 411/982 (41%), Gaps = 141/982 (14%)
Query: 407 TDSSNLNVSEPRAVIPGLRSSTFYNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVS 466
T ++ V + ++ S Y LG IE P P + VT +
Sbjct: 273 TPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPM-VTENT 331
Query: 467 TTEIGLAWSSHDAESFQMHI------TQEGAGNSRVEITTNQSIIIGGLFPGTKYCFEIV 520
T I + W S + + ++ +Q+G + +ITT + IGGL P ++Y +
Sbjct: 332 ATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTR-YSIGGLSPNSEYEIWVS 390
Query: 521 PKGPNGTEGASRTVCNRT----VPSAVFDIHVVYVTTTEMWLDWKSPDGASE----YVYH 572
G S +V RT SA ++ ++ T M + W+ P + Y +
Sbjct: 391 AVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVY 450
Query: 573 LVIESKH--GSNHTSTYDKAI--TLQGLIPGTLYNITI---SPEVDHVWGDPNST-AQYT 624
+E +H G+ D ++ T+ L+ Y + + + D DP Q
Sbjct: 451 YTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQG 510
Query: 625 RPSNVSNIDVSTNT-TAATLSWQNFDDASPTYSYCLLIEKAGNSSNATQVVTDIGITDAT 683
P N+ + T+ TLSW S Y LL + + + T
Sbjct: 511 VPGQPMNLRAEARSETSITLSWSPPRQES-IIKYELLFREGDHGREVGRTFDPT--TSYV 567
Query: 684 VTELIPGSSYTVEIFAQVGDGIKSLEPGRKSFCTDPASMASFDCEVVPKEPALVLKWTCP 743
V +L P + Y + A+ G+ + P + S +F +++ K L L W P
Sbjct: 568 VEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSISPKNFKVKMIMKTSVL-LSWEFP 626
Query: 744 PGANAGFELEVSSGAWNNATHLESCSSENGTEYRTEVTYLNFSTSYNISITTVSCGKMAA 803
N+ ++ +N T +G + +T+L T YN +T + G
Sbjct: 627 DNYNSPTPYKIQ---YNGLT-----LDVDGRTTKKLITHLKPHTFYNFVLT--NRGSSLG 676
Query: 804 PTRNTCTTGITDPPPPDGSPNITSVSHNSVKVKFSGF-------EASHGPIKAYAVILTT 856
+ T T T +G P++ K GF S P+++Y +++
Sbjct: 677 GLQQTVTAW-TAFNLLNGKPSVAP------KPDADGFIMVYLPDGQSPVPVQSYFIVMVP 729
Query: 857 GEAGHPSADVLKYTYEDFKKGASDTYVTYLIRTEEKGRSQSLSEVLKYEIDVGNESTTLG 916
+K ++T L E+ L E+++ D+
Sbjct: 730 -----------------LRKSRGGQFLTPLGSPED----MDLEELIQ---DISRLQRRSL 765
Query: 917 YYNGKLEPLGSYRACVAGFTNITFHP---------QNKGLIDGAESYVSF---------- 957
++ +LE Y A TFHP N+GL G YV F
Sbjct: 766 RHSRQLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPG-HRYVLFVLAVLQKSEP 824
Query: 958 ----SRYSDAVSL--PQDPGVICGA-----VFGCIFGALVIVTVGGFIFWRKKRKDAKN- 1005
S +SD L P ++ G V G + + I+ + I K + D+K
Sbjct: 825 TFAASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRK 884
Query: 1006 ----------NEVSFSQIKPKKSKLIRVENFEA----------------YFKKQQADSNC 1039
N + PK +R NF+ + ++ +A+ +
Sbjct: 885 DSEPRTKCLLNNADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSL 944
Query: 1040 GFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLS-VQTHSTDDYINAN 1098
++EYE + G + L N+ KNRY NV+ YD SRV L ++ DYINAN
Sbjct: 945 KLSQEYESID-PGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINAN 1003
Query: 1099 YMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQA 1158
Y+ GY + +IATQGPLP T DFWRMVWE+ I+M+T+ E+ R KC++YWP++
Sbjct: 1004 YVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGT 1063
Query: 1159 QDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINF 1218
+ YG I V + I L + +R F++ +SE +RQF FT+WPDHGVP+ + F
Sbjct: 1064 ETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAF 1123
Query: 1219 RYLVRDYMKQSPPES-PILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMH 1277
+R +PP++ PI+VHCSAGVGRTG FI ID ++ +I+ E TVDVYG V +R
Sbjct: 1124 ---LRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQ 1180
Query: 1278 RPLMVQTEDQYVFLNQCVLDIV 1299
R MVQTEDQY F+++ +L+ V
Sbjct: 1181 RNYMVQTEDQYSFIHEALLEAV 1202
Score = 210 bits (534), Expect = 8e-54
Identities = 104/244 (42%), Positives = 152/244 (62%), Gaps = 1/244 (0%)
Query: 1059 AAELAENRGKNRYNNVLPYDISRVKLS-VQTHSTDDYINANYMPGYHSKKDFIATQGPLP 1117
+A L N+ KNR N++PY+ +RV L ++ DYINA+++ GY +K +IATQGPL
Sbjct: 1252 SANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLA 1311
Query: 1118 NTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEW 1177
T +DFWRM+WE N ++MLTK E GR KC +YWP++++ Y V +E +P++
Sbjct: 1312 ETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQY 1371
Query: 1178 TIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILV 1237
+R+F V + + +S +RQF FT WP+ GVP + + I+F V +Q + PI V
Sbjct: 1372 ILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISV 1431
Query: 1238 HCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLD 1297
HCSAGVGRTG FI + ++ ++ E VD++ V LR RP MVQTED+Y F Q L+
Sbjct: 1432 HCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALE 1491
Query: 1298 IVRS 1301
+ S
Sbjct: 1492 YLGS 1495
Score = 46.6 bits (109), Expect = 2e-04
Identities = 75/318 (23%), Positives = 120/318 (37%), Gaps = 24/318 (7%)
Query: 328 TEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTN----AIQVFDVTAVNISATSLT 383
T + GL P + Y V + + G +++ RT A +V A +SAT++
Sbjct: 372 TRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMI 431
Query: 384 LIWKVSDNESSSNYTYKI-------HVAGETDSSNLNVSEPRAVIPGLRSSTFYNITVCP 436
+ W+ + Y++ H G N++ S V L T Y + V
Sbjct: 432 VQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDET-YTVRVLA 490
Query: 437 VLGDIEGTPGF-LQVHTP---PVPVSDFRVTVVSTTEIGLAWSSHDAESFQMH--ITQEG 490
+G +QV T P + R S T I L+WS ES + + +EG
Sbjct: 491 FTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREG 550
Query: 491 AGNSRVEITTNQ--SIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTVPS-AVFDIH 547
V T + S ++ L P T+Y F + + P G + V RT+ S + +
Sbjct: 551 DHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSISPKNFK 610
Query: 548 VVYVTTTEMWLDWKSPDG-ASEYVYHLVIESKHGSNHTSTYDKAITLQGLIPGTLYNITI 606
V + T + L W+ PD S Y + T K IT L P T YN +
Sbjct: 611 VKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKKLIT--HLKPHTFYNFVL 668
Query: 607 SPEVDHVWGDPNSTAQYT 624
+ + G + +T
Sbjct: 669 TNRGSSLGGLQQTVTAWT 686
>gi|222537743 protein tyrosine phosphatase, receptor type, Q [Homo
sapiens]
Length = 2299
Score = 256 bits (655), Expect = 8e-68
Identities = 289/1132 (25%), Positives = 465/1132 (41%), Gaps = 149/1132 (13%)
Query: 309 HDESLVGPVDPSSGQQSRDTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQ 368
+D +L GP + S S D ++L L P T Y+ ++ G G + F T+
Sbjct: 1184 YDLTLQGPNENYSFITS-DNYIILEELSPFTLYSFFAAARTRKGL-GPSSILFFYTDESV 1241
Query: 369 VF----DVTAVNISATSLTLIWKVSDNESS--SNYTYKIHVAGETDS---SNLNVSEPRA 419
++T +N ++ + L W S Y++KIH ETD+ N++ + A
Sbjct: 1242 PLAPPQNLTLINCTSDFVWLKWSPSPLPGGIVKVYSFKIH-EHETDTIYYKNISGFKTEA 1300
Query: 420 VIPGLRSSTFYNITVCPVL-----GDIEGTPGFLQVHTPPVPVSDFRVTVVSTTEIGLAW 474
+ GL + Y+I V F + P V + + S + + W
Sbjct: 1301 KLVGLEPVSTYSIRVSAFTKVGNGNQFSNVVKFTTQESVPDVVQNMQCMATSWQSVLVKW 1360
Query: 475 SSHDAES---FQMHITQEGAGNSRVEITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGAS 531
+ Q +T E NS + L T Y F++ G EG
Sbjct: 1361 DPPKKANGIITQYMVTVER--NSTKVSPQDHMYTFIKLLANTSYVFKVRASTSAG-EGDE 1417
Query: 532 RTVCN-----RTVPSAVFDIHVVYVTTTEMWLDWKSPDGASEYVYHLVIESKHGSNHTST 586
T C+ TVPS +I V +T L W PD Y + I ++ +
Sbjct: 1418 ST-CHVSTLPETVPSVPTNIAFSDVQSTSATLTWIRPDTILGYFQNYKITTQLRAQKCKE 1476
Query: 587 YDKAI------------------TLQGLIPGTLYNITISPEVDHVWGDPN---STAQYTR 625
++ T+ GL Y ++ + +G+ + ST
Sbjct: 1477 WESEECVEYQKIQYLYEAHLTEETVYGLKKFRWYRFQVAASTNAGYGNASNWISTKTLPG 1536
Query: 626 PSN--VSNIDV-STNTTAATLSWQNFDDASPTYSYCLLIEKAGNSS-NATQVVTDIGITD 681
P + N+ V +T+ + ++SW + Y + ++ N N + + ++
Sbjct: 1537 PPDGPPENVHVVATSPFSISISWSEPAVITGPTCYLIDVKSVDNDEFNISFIKSNEENKT 1596
Query: 682 ATVTELIPGSSYTVEIFAQVGDGIKSLEPGRKSFCTDPASMASFDCEVVPKEPALVLKWT 741
+ +L + Y+V I A G+ + G+ S A M E PK+P + +
Sbjct: 1597 IEIKDLEIFTRYSVVITAFTGNISAAYVEGKSS-----AEMIVTTLESAPKDPPNNMTFQ 1651
Query: 742 CPPGANAGFELEVSSGAWNNAT-------------------HLESCSSENGTEYRTEVTY 782
P F+L + N H S + T +
Sbjct: 1652 KIPDEVTKFQLTFLPPSQPNGNIQVYQALVYREDDPTAVQIHNLSIIQKTNTFVIAMLEG 1711
Query: 783 LNFSTSYNISITTVSCGKMAAPTRNTCTTGITDPPPPDGSPN----------ITSVSHNS 832
L +YNIS+ V+ T I P P P +TS + +
Sbjct: 1712 LKGGHTYNISVYAVNSAGAGPKVPMRITMDIKAPARPKTKPTPIYDATGKLLVTSTTI-T 1770
Query: 833 VKVKFSGFEASHGPIKAYAVILTTGEAGHPSADVLKYTYEDFKKGASDTYVTYLIRTEEK 892
+++ + HGPIK V++T A H +V K+ F K Y T +
Sbjct: 1771 IRMPICYYSDDHGPIKNVQVLVTETGAQH-DGNVTKWYDAYFNKARP--YFT------NE 1821
Query: 893 GRSQSLSEVLKYEIDVGNESTTLGYYNGKLEPLGSYRACVAGFTNITFHPQNKGLIDGAE 952
G K + E +G N + P + C N P+ + L
Sbjct: 1822 GFPNPPCTEGKTKFSGNEEIYIIGADNACMIPGNEDKIC-----NGPLKPKKQYLFKFRA 1876
Query: 953 SYV----SFSRYSDAVS-----LPQDPGVICGAVFGCIFGALVIVT-VGGFIFWRKKRKD 1002
+ + + S YSD V L + I +V CI +++ T + F R+K+K+
Sbjct: 1877 TNIMGQFTDSDYSDPVKTLGEGLSERTVEIILSVTLCILSIILLGTAIFAFARIRQKQKE 1936
Query: 1003 AKNNEVSFSQIKPKKSKL----------------------------IRVENFEAYFKKQQ 1034
++I K KL I ++F + ++
Sbjct: 1937 GGTYSPQDAEIIDTKLKLDQLITVADLELKDERLTRLLSYRKSIKPISKKSFLQHVEELC 1996
Query: 1035 ADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLSVQTHST-DD 1093
++N F EE+ +L A+L NR KNR+ N+ PY+ +RVKL D
Sbjct: 1997 TNNNLKFQEEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSD 2056
Query: 1094 YINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYW 1153
YINA+Y+ GY +FIATQGPLP T+ DFWRMVWE ++MLT+C E+GR +C +YW
Sbjct: 2057 YINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYW 2116
Query: 1154 P--SKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDT 1211
P +K +GDI + E V +WTIRD ++ + + +RQ +FT+WP+HGVP+
Sbjct: 2117 PEDNKPVTVFGDIVITKLMEDVQIDWTIRDLKIE--RHGDCMTVRQCNFTAWPEHGVPEN 2174
Query: 1212 TDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIV 1271
+ LI+F LVR ++ +P++VHCSAGVGRTG FIA+D L I + + VD+YG+V
Sbjct: 2175 SAPLIHFVKLVR--ASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLV 2232
Query: 1272 YDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQKDSKVDLIYQNTTAMTIYENL 1323
+LR R MVQ QY+FL+QC+LD++ S K S + + N +A+ ++L
Sbjct: 2233 AELRSERMCMVQNLAQYIFLHQCILDLL-SNKGSNQPICFVNYSALQKMDSL 2283
Score = 52.0 bits (123), Expect = 4e-06
Identities = 104/445 (23%), Positives = 176/445 (39%), Gaps = 48/445 (10%)
Query: 442 EGTPGFLQVHTP---PVPVSDFRVTVVSTTEIGLAWSSHDAESFQM-HIT---QEGAGNS 494
EG P L V T P + +S++ I L W + + ++ H T E N
Sbjct: 554 EGPPTVLSVRTRQQVPSSIKIINYKNISSSSILLYWDPPEYPNGKITHYTIYAMELDTNR 613
Query: 495 RVEITT-NQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRT--VCNRTVP----SAVFDIH 547
+ITT + S +I GL TKY + G S + RT S+ D+
Sbjct: 614 AFQITTIDNSFLITGLKKYTKYKMRVAASTHVGESSLSEENDIFVRTSEDEPESSPQDVE 673
Query: 548 VVYVTTTEMWLDWKSPDGASEYVYHLVIESKHGSN----HTSTYDKAITLQGLIPGTLYN 603
V+ VT E+ L W P+ + + + K+ +TST D I L+ L P TLYN
Sbjct: 674 VIDVTADEIRLKWSPPEKPNGIIIAYEVLYKNIDTLYMKNTSTTD--IILRNLRPHTLYN 731
Query: 604 ITISPEVDHVWGDPNSTAQYTRPSNVSNIDVSTNTTAATLSWQNFD-----DASPT---Y 655
I++ G+ S+ R S N T +S + +SP
Sbjct: 732 ISVRSYTRFGHGNQVSSLLSVRTSETVPDSAPENITYKNISSGEIELSFLPPSSPNGIIQ 791
Query: 656 SYCLLIEKAGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQV--GDGIKSLEPGRK 713
Y + ++++ + T T + + L + Y +E+ A G+G++S
Sbjct: 792 KYTIYLKRSNGNEERTINTTSL---TQNIKVLKKYTQYIIEVSASTLKGEGVRS---API 845
Query: 714 SFCTDPASMASFDCEVVPKEPALV---LKWTCPPGANAGFELEVSSGAWNNATHLESCSS 770
S T+ + S + K+ + V L W PP G L + WN + S +
Sbjct: 846 SILTEEDAPDSPPQDFSVKQLSGVTVKLSWQ-PPLEPNGIILYYTVYVWNRS----SLKT 900
Query: 771 ENGTEYRTEVTYLNFSTSYNISITTVSCGKMAAPTRNTCTTGITDPPPPDGSPN---ITS 827
N TE E++ L+++ Y+ + T S TR+ + T P P +
Sbjct: 901 INVTETSLELSDLDYNVEYS-AYVTASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYAN 959
Query: 828 VSHNSVKVKFSGFEASHGPIKAYAV 852
+S +S+ + ++ +G I+ Y+V
Sbjct: 960 LSSSSIILFWTPPSKPNGIIQYYSV 984
Score = 45.8 bits (107), Expect = 3e-04
Identities = 59/293 (20%), Positives = 110/293 (37%), Gaps = 20/293 (6%)
Query: 373 TAVNISATSLTLIWKVSDNESSSNYTYKIHVAGETDSSNLNVSEPRAVIPGLRSSTFYNI 432
T N+S+TS+ L W + + +Y + + G ++ + S+ ++ L T Y+
Sbjct: 1158 TFKNLSSTSVLLSWDPPVKPNGAIISYDLTLQGPNENYSFITSDNYIILEELSPFTLYSF 1217
Query: 433 TVCPVLGDIEGTPGFLQVHT----PPVPVSDFRVTVVSTTEIGLAWSSHDAE-------S 481
G L +T P P + + ++ + L WS S
Sbjct: 1218 FAAARTRKGLGPSSILFFYTDESVPLAPPQNLTLINCTSDFVWLKWSPSPLPGGIVKVYS 1277
Query: 482 FQMHITQEGAGNSRVEITTNQSIIIGGLFPGTKYCFEI--VPKGPNGTEGAS--RTVCNR 537
F++H + + + GL P + Y + K NG + ++ +
Sbjct: 1278 FKIHEHETDTIYYKNISGFKTEAKLVGLEPVSTYSIRVSAFTKVGNGNQFSNVVKFTTQE 1337
Query: 538 TVPSAVFDIHVVYVTTTEMWLDWKSPDGASEYVYHLVIESKHGSNHTSTYDKAITLQGLI 597
+VP V ++ + + + + W P A+ + ++ + S S D T L+
Sbjct: 1338 SVPDVVQNMQCMATSWQSVLVKWDPPKKANGIITQYMVTVERNSTKVSPQDHMYTFIKLL 1397
Query: 598 PGTLYNITISPEVDHVWGDPN----STAQYTRPSNVSNIDVS-TNTTAATLSW 645
T Y + GD + ST T PS +NI S +T+ATL+W
Sbjct: 1398 ANTSYVFKVRASTSAGEGDESTCHVSTLPETVPSVPTNIAFSDVQSTSATLTW 1450
Score = 40.0 bits (92), Expect = 0.015
Identities = 129/670 (19%), Positives = 243/670 (36%), Gaps = 94/670 (14%)
Query: 119 PSPVFDIKAVSISPTNVILTWKSNDTAASEYKYVVKHKMENEKT----ITVVHQPWCNIT 174
PS + I +IS ++++L W + + + + ME + IT + + IT
Sbjct: 569 PSSIKIINYKNISSSSILLYWDPPEYPNGKITHYTIYAMELDTNRAFQITTIDNSFL-IT 627
Query: 175 GLRPATSYVFSITPG--IGNETWGDPRVIKVIT-EPIPVS---DLRVALTGVRKAALSWS 228
GL+ T Y + +G + + I V T E P S D+ V + L WS
Sbjct: 628 GLKKYTKYKMRVAASTHVGESSLSEENDIFVRTSEDEPESSPQDVEVIDVTADEIRLKWS 687
Query: 229 ---NGNGTASCRVLLESIGSHEELTQDSRLQVNISGLKPGVQYNINPYLLQSNKTKGDPL 285
NG +L + S + + L+P YNI+ ++S G
Sbjct: 688 PPEKPNGIIIAYEVLYKNIDTLYMKNTSTTDIILRNLRPHTLYNIS---VRSYTRFGHGN 744
Query: 286 GTEGGLDASNTERSRAGSPTAPVHDE--------SLVGPVDP-------------SSGQQ 324
L +E +P + S + P P S+G +
Sbjct: 745 QVSSLLSVRTSETVPDSAPENITYKNISSGEIELSFLPPSSPNGIIQKYTIYLKRSNGNE 804
Query: 325 SR--DTEVLLVGLEPGTRYNATVYSQAANGTEGQ-----PQAIEFRTNAIQV--FDVTAV 375
R +T L ++ +Y + +A+ +G+ P +I +A D +
Sbjct: 805 ERTINTTSLTQNIKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSPPQDFSVK 864
Query: 376 NISATSLTLIWKVSDNESSSNYTYKIHVAGETDSSNLNVSEPRAVIPGLRSSTFYN--IT 433
+S ++ L W+ + Y ++V + +NV+E + L + Y+ +T
Sbjct: 865 QLSGVTVKLSWQPPLEPNGIILYYTVYVWNRSSLKTINVTETSLELSDLDYNVEYSAYVT 924
Query: 434 VCPVLGDIEGTPGFLQVHTPPV----PVSDFRVTVVSTTEIGLAWSS------------- 476
GD + + TP P D +S++ I L W+
Sbjct: 925 ASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIILFWTPPSKPNGIIQYYSV 984
Query: 477 ---HDAESFQMHITQEGAGNSRVEITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRT 533
+ + +F + T N +T S II L + Y F + G S
Sbjct: 985 YYRNTSGTFMQNFTLHEVTNDFDNMTV--STIIDKLTIFSYYTFWLTASTSVGNGNKSSD 1042
Query: 534 VC----NRTVPSA-VFDIHVVYVTTTEMWLDW---KSPDGASEYVYHLVIES--KHGSNH 583
+ ++ +P V ++ +++T + + W P+G Y L+++ +H
Sbjct: 1043 IIEVYTDQDIPEGFVGNLTYESISSTAINVSWVPPAQPNGLVFYYVSLILQQTPRHVRPP 1102
Query: 584 TSTYDKAITLQGLIPGTLYNITISPEVDHVWGDPNSTAQYTR-------PSNVSNIDVST 636
TY+++I L T Y + I+P + + D + Y + S + N +
Sbjct: 1103 LVTYERSIYFDNLEKYTDYILKITPSTEKGFSDTYTAQLYIKTEEDVPETSPIINTFKNL 1162
Query: 637 NTTAATLSWQ-NFDDASPTYSYCLLIEKAGNSSNATQVVTDIGITDATVTELIPGSSYTV 695
++T+ LSW SY L ++ G + N + + +D I + EL P + Y+
Sbjct: 1163 SSTSVLLSWDPPVKPNGAIISYDLTLQ--GPNENYSFITSDNYI---ILEELSPFTLYSF 1217
Query: 696 EIFAQVGDGI 705
A+ G+
Sbjct: 1218 FAAARTRKGL 1227
Score = 37.4 bits (85), Expect = 0.097
Identities = 44/178 (24%), Positives = 75/178 (42%), Gaps = 27/178 (15%)
Query: 253 SRLQVNISGLKPGVQYNIN------------PYLLQSNKTK--------GDPLGTEGGLD 292
S QV++S + PG +Y+I ++ +N TK G+ +G+ G L
Sbjct: 15 SETQVDVSNVVPGTRYDITISSISTTYTSPVTRIVTTNVTKPGPPVFLAGERVGSAGILL 74
Query: 293 ASNTERSRAGSPTAPVHDESLVGPVDPSSGQQSRDT----EVLLVGLEPGTRYNATVYSQ 348
+ NT + G + + V P + Q R EVLL L PGT Y V ++
Sbjct: 75 SWNTPPNPNGRIISYIVKYKEVCPWMQTVYTQVRSKPDSLEVLLTNLNPGTTYEIKVAAE 134
Query: 349 AANGTEGQPQAIEFRTNAI---QVFDVTAVNISATSLTLIWKVSDNESSSNYTYKIHV 403
+ G F+T +V ++T +A+++ LIW + + ++KI V
Sbjct: 135 NSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIWYLPRQPNGKITSFKISV 192
>gi|148539860 protein tyrosine phosphatase, receptor type, T isoform 2
precursor [Homo sapiens]
Length = 1441
Score = 247 bits (630), Expect = 6e-65
Identities = 137/294 (46%), Positives = 178/294 (60%), Gaps = 11/294 (3%)
Query: 1008 VSFSQIKPKKSKLIRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRG 1067
V S + + IRV + + + + GF EEYE L G + A+ ENR
Sbjct: 856 VEMSYPRDQFQPAIRVADLLQHITQMKRGQGYGFKEEYEALP-EGQTASWDTAKEDENRN 914
Query: 1068 KNRYNNVLPYDISRVKLSV---QTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFW 1124
KNRY N++ YD SRV+L V HS DYINANY+ GYH + +IATQGP+ T+KDFW
Sbjct: 915 KNRYGNIISYDHSRVRLLVLDGDPHS--DYINANYIDGYHRPRHYIATQGPMQETVKDFW 972
Query: 1125 RMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTV 1184
RM+W++N +I+M+T VE GR KC YWP + YGDI V + L E+ IR FTV
Sbjct: 973 RMIWQENSASIVMVTNLVEVGRVKCVRYWPD-DTEVYGDIKVTLIETEPLAEYVIRTFTV 1031
Query: 1185 KNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPES-PILVHCSAGV 1243
+ E LR FHFTSWPDHGVP L+ F VR +PPE+ PI+VHCSAG
Sbjct: 1032 QKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGF---VRQVKFLNPPEAGPIVVHCSAGA 1088
Query: 1244 GRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLD 1297
GRTG FIAID ++ ENE VD++ V +LR R +VQTE+QYVF++ +L+
Sbjct: 1089 GRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILE 1142
Score = 125 bits (313), Expect = 4e-28
Identities = 84/283 (29%), Positives = 134/283 (47%), Gaps = 12/283 (4%)
Query: 1029 YFKKQQADSNCGFAEEYEDLKLVGISQPKYAAE------LAENRGKNRYNNVLPYDISRV 1082
Y+ + D ++ ++ + + I P+ E L N KNR +VLP D
Sbjct: 1160 YYNISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLP 1219
Query: 1083 KLSVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCV 1142
L + +YINA M + F+ TQ PLPNT+ DFWR+V++ N +++ML +
Sbjct: 1220 FLISVDGESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEM- 1278
Query: 1143 EQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSES--HPLRQFHF 1200
C +YWP K + YG I V S + + R F + N+ + ++ +
Sbjct: 1279 -DTAQFCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQY 1337
Query: 1201 TSWPDHG--VPDTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQ 1258
WP + P LL R L + + E +VHC G GR+GTF AI +
Sbjct: 1338 IGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEM 1397
Query: 1259 IENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRS 1301
I+ +N +DV+ IV LR ++ MV+T +QY F+ + L+ + S
Sbjct: 1398 IQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSS 1440
Score = 36.6 bits (83), Expect = 0.17
Identities = 30/107 (28%), Positives = 51/107 (47%), Gaps = 15/107 (14%)
Query: 314 VGPVDPSSGQQSR---------DTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRT 364
VG +DPS+ S+ +T L VGL PGT Y+ T+ + A G G P T
Sbjct: 526 VGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGF-GPPVTTRIAT 584
Query: 365 N----AIQVFDV-TAVNISATSLTLIWKVSDNESSSNYTYKIHVAGE 406
++ +D T +N + T++T++ K + + + Y++ V E
Sbjct: 585 KISAPSMPEYDTDTPLNETDTTITVMLKPAQSRGAPVSVYQLVVKEE 631
Score = 35.8 bits (81), Expect = 0.28
Identities = 62/318 (19%), Positives = 126/318 (39%), Gaps = 21/318 (6%)
Query: 626 PSNVSNIDVSTNTTAATLSWQNFDDA-SPTYSYCLLIEKAGNSSNATQVVTDIGITDA-- 682
P NV +D+ TL W+ F A + +SY L ++ + ++ T +
Sbjct: 390 PQNVEIVDIRARQL--TLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVIQTSSHY 447
Query: 683 TVTELIPGSSYTVEIFAQVGDG-IKSLEPGRKSFCTDPASMASFDCEVVPKEPALVLKWT 741
T+ L P + + + +G ++S E ++ P ++ + P E + ++W
Sbjct: 448 TLRGLRPFMTIRLRLLLSNPEGRMESEELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWK 507
Query: 742 CPPGANAGFEL-EVSSGAWNNATHLESCSSENGTEY--RTEVTYLNFS----TSYNISIT 794
P N L E++ A + SS+ G + R E +L T+Y+ +I
Sbjct: 508 PPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIK 567
Query: 795 TVSCGKMAAPTRNTCTTGITDPPPPDGSPNIT-SVSHNSVKVKFSGFEASHGPIKAYAVI 853
+ P T I+ P P+ + + + ++ V ++ P+ Y ++
Sbjct: 568 ASTAKGFGPPVTTRIATKISAPSMPEYDTDTPLNETDTTITVMLKPAQSRGAPVSVYQLV 627
Query: 854 LTTG--EAGHPSADVLK-YTYEDFKKGASDTYVTYLIRTEEKGRSQSLSEVLKYEIDVGN 910
+ + +AD+++ ++ + AS + E K + +++ VG+
Sbjct: 628 VKEERLQKSRRAADIIECFSVPVSYRNASSLDSLHYFAAELKPANLPVTQ----PFTVGD 683
Query: 911 ESTTLGYYNGKLEPLGSY 928
T GY+N L PL SY
Sbjct: 684 NKTYNGYWNPPLSPLKSY 701
>gi|148539858 protein tyrosine phosphatase, receptor type, T isoform 1
precursor [Homo sapiens]
Length = 1460
Score = 247 bits (630), Expect = 6e-65
Identities = 137/294 (46%), Positives = 178/294 (60%), Gaps = 11/294 (3%)
Query: 1008 VSFSQIKPKKSKLIRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRG 1067
V S + + IRV + + + + GF EEYE L G + A+ ENR
Sbjct: 875 VEMSYPRDQFQPAIRVADLLQHITQMKRGQGYGFKEEYEALP-EGQTASWDTAKEDENRN 933
Query: 1068 KNRYNNVLPYDISRVKLSV---QTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFW 1124
KNRY N++ YD SRV+L V HS DYINANY+ GYH + +IATQGP+ T+KDFW
Sbjct: 934 KNRYGNIISYDHSRVRLLVLDGDPHS--DYINANYIDGYHRPRHYIATQGPMQETVKDFW 991
Query: 1125 RMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTV 1184
RM+W++N +I+M+T VE GR KC YWP + YGDI V + L E+ IR FTV
Sbjct: 992 RMIWQENSASIVMVTNLVEVGRVKCVRYWPD-DTEVYGDIKVTLIETEPLAEYVIRTFTV 1050
Query: 1185 KNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPES-PILVHCSAGV 1243
+ E LR FHFTSWPDHGVP L+ F VR +PPE+ PI+VHCSAG
Sbjct: 1051 QKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGF---VRQVKFLNPPEAGPIVVHCSAGA 1107
Query: 1244 GRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLD 1297
GRTG FIAID ++ ENE VD++ V +LR R +VQTE+QYVF++ +L+
Sbjct: 1108 GRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILE 1161
Score = 125 bits (313), Expect = 4e-28
Identities = 84/283 (29%), Positives = 134/283 (47%), Gaps = 12/283 (4%)
Query: 1029 YFKKQQADSNCGFAEEYEDLKLVGISQPKYAAE------LAENRGKNRYNNVLPYDISRV 1082
Y+ + D ++ ++ + + I P+ E L N KNR +VLP D
Sbjct: 1179 YYNISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLP 1238
Query: 1083 KLSVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCV 1142
L + +YINA M + F+ TQ PLPNT+ DFWR+V++ N +++ML +
Sbjct: 1239 FLISVDGESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEM- 1297
Query: 1143 EQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSES--HPLRQFHF 1200
C +YWP K + YG I V S + + R F + N+ + ++ +
Sbjct: 1298 -DTAQFCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQY 1356
Query: 1201 TSWPDHG--VPDTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQ 1258
WP + P LL R L + + E +VHC G GR+GTF AI +
Sbjct: 1357 IGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEM 1416
Query: 1259 IENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRS 1301
I+ +N +DV+ IV LR ++ MV+T +QY F+ + L+ + S
Sbjct: 1417 IQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSS 1459
Score = 36.6 bits (83), Expect = 0.17
Identities = 30/107 (28%), Positives = 51/107 (47%), Gaps = 15/107 (14%)
Query: 314 VGPVDPSSGQQSR---------DTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRT 364
VG +DPS+ S+ +T L VGL PGT Y+ T+ + A G G P T
Sbjct: 526 VGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGF-GPPVTTRIAT 584
Query: 365 N----AIQVFDV-TAVNISATSLTLIWKVSDNESSSNYTYKIHVAGE 406
++ +D T +N + T++T++ K + + + Y++ V E
Sbjct: 585 KISAPSMPEYDTDTPLNETDTTITVMLKPAQSRGAPVSVYQLVVKEE 631
Score = 35.8 bits (81), Expect = 0.28
Identities = 62/318 (19%), Positives = 126/318 (39%), Gaps = 21/318 (6%)
Query: 626 PSNVSNIDVSTNTTAATLSWQNFDDA-SPTYSYCLLIEKAGNSSNATQVVTDIGITDA-- 682
P NV +D+ TL W+ F A + +SY L ++ + ++ T +
Sbjct: 390 PQNVEIVDIRARQL--TLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVIQTSSHY 447
Query: 683 TVTELIPGSSYTVEIFAQVGDG-IKSLEPGRKSFCTDPASMASFDCEVVPKEPALVLKWT 741
T+ L P + + + +G ++S E ++ P ++ + P E + ++W
Sbjct: 448 TLRGLRPFMTIRLRLLLSNPEGRMESEELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWK 507
Query: 742 CPPGANAGFEL-EVSSGAWNNATHLESCSSENGTEY--RTEVTYLNFS----TSYNISIT 794
P N L E++ A + SS+ G + R E +L T+Y+ +I
Sbjct: 508 PPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIK 567
Query: 795 TVSCGKMAAPTRNTCTTGITDPPPPDGSPNIT-SVSHNSVKVKFSGFEASHGPIKAYAVI 853
+ P T I+ P P+ + + + ++ V ++ P+ Y ++
Sbjct: 568 ASTAKGFGPPVTTRIATKISAPSMPEYDTDTPLNETDTTITVMLKPAQSRGAPVSVYQLV 627
Query: 854 LTTG--EAGHPSADVLK-YTYEDFKKGASDTYVTYLIRTEEKGRSQSLSEVLKYEIDVGN 910
+ + +AD+++ ++ + AS + E K + +++ VG+
Sbjct: 628 VKEERLQKSRRAADIIECFSVPVSYRNASSLDSLHYFAAELKPANLPVTQ----PFTVGD 683
Query: 911 ESTTLGYYNGKLEPLGSY 928
T GY+N L PL SY
Sbjct: 684 NKTYNGYWNPPLSPLKSY 701
>gi|157419150 protein tyrosine phosphatase, receptor type, M isoform 2
precursor [Homo sapiens]
Length = 1452
Score = 244 bits (624), Expect = 3e-64
Identities = 129/279 (46%), Positives = 170/279 (60%), Gaps = 7/279 (2%)
Query: 1021 IRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDIS 1080
IRV + + + + GF EEYE G S P +A+ ENR KNRY N++ YD S
Sbjct: 880 IRVADLLQHITQMKCAEGYGFKEEYESF-FEGQSAPWDSAKKDENRMKNRYGNIIAYDHS 938
Query: 1081 RVKL-SVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLT 1139
RV+L +++ + DYIN NY+ GYH +IATQGP+ T+ DFWRMVW +N +IIM+T
Sbjct: 939 RVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVT 998
Query: 1140 KCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFH 1199
VE GR KC +YWP + Y DI V + +L E+ IR F V+ E +RQFH
Sbjct: 999 NLVEVGRVKCCKYWPD-DTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFH 1057
Query: 1200 FTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPES-PILVHCSAGVGRTGTFIAIDRLIYQ 1258
FT WPDHGVP L+ F VR +SPP + P++VHCSAG GRTG FI ID ++
Sbjct: 1058 FTGWPDHGVPYHATGLLGF---VRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDM 1114
Query: 1259 IENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLD 1297
E E VD+Y V +LR R MVQTE+QYVF++ +L+
Sbjct: 1115 AEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILE 1153
Score = 125 bits (314), Expect = 3e-28
Identities = 88/285 (30%), Positives = 133/285 (46%), Gaps = 16/285 (5%)
Query: 1029 YFKKQQADSNCGFAEEYEDLKLVGISQPKYAAE------LAENRGKNRYNNVLPYDISRV 1082
Y+ + D ++ E+ + + + P E L N KNR ++LP D
Sbjct: 1171 YYDMNKLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLP 1230
Query: 1083 KLSVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCV 1142
L + +YINA M Y FI TQ PLPNT+KDFWR+V + + +++ML V
Sbjct: 1231 FLITIDGESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLND-V 1289
Query: 1143 EQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSES--HPLRQFHF 1200
+ + C +YWP +G I V S + + R F + N + ++QF F
Sbjct: 1290 DPAQL-CPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGYRMVQQFQF 1348
Query: 1201 TSWPDHGVPDTTDLLINFRYLVRDYMK----QSPPESPILVHCSAGVGRTGTFIAIDRLI 1256
WP + DT +F L+R K + E +VHC G GR+GTF AI +
Sbjct: 1349 LGWPMY--RDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVC 1406
Query: 1257 YQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRS 1301
+ ++ TVDV+ V LR ++P MV DQY F + L+ + S
Sbjct: 1407 EMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNS 1451
Score = 47.0 bits (110), Expect = 1e-04
Identities = 132/622 (21%), Positives = 222/622 (35%), Gaps = 109/622 (17%)
Query: 448 LQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDAESFQ----------MHITQEGAGNSRVE 497
L V PPVP++ ++ V T + W +A S + T G+ N R
Sbjct: 276 LVVKEPPVPIAPPQLASVGATYL---WIQLNANSINGDGPIVAREVEYCTASGSWNDRQP 332
Query: 498 ITTNQSIIIGGLFPGTKYCFEIV----PKGPNGTEGAS---RTVCNRTVPSAVFDIHVVY 550
+ + S IG L P T+Y ++ +G G+ G + RT C + + VV
Sbjct: 333 VDST-SYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRTKCADPMRGPR-KLEVVE 390
Query: 551 VTTTEMWLDWKSPDGASEYVYHLVIESKHGSNHTSTYDKAITLQGLIPGTLYNITISPEV 610
V + ++ + W+ P G + + H N T Y + Q + EV
Sbjct: 391 VKSRQITIRWE-PFGYN-------VTRCHSYNLTVHYCYQVGGQE---------QVREEV 433
Query: 611 DHVWGDPNSTAQYTRPSNVSNIDVSTNTTAATLSWQNFDDASPTYSYCLLIEKAGNSSNA 670
W NS Q+T ++N+ TN + + L+ + S
Sbjct: 434 S--WDTENSHPQHT----ITNLSPYTNVSVKLI---------------LMNPEGRKESQE 472
Query: 671 TQVVTDIGITDATVTELIPGSSYTVEIFAQVGDGIKSLEPGRKSFCTDPASMASFDCEVV 730
V TD + A TE I GS++ +IF Q + ++ T A ++SFD E+
Sbjct: 473 LIVQTDEDLPGAVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKA-VSSFDPEI- 530
Query: 731 PKEPALVLKWTCPPGANAGFELEVSSGAWNNATHLESCSSENGTEYRTEVTYLNFSTSYN 790
+L SG S+ G E L T+Y+
Sbjct: 531 --------------------DLSNQSGR----------VSKLGNETHFLFFGLYPGTTYS 560
Query: 791 ISITTVSCGKMAAPTRNTCTTGITDPPPPDGSPNIT-SVSHNSVKVKFSGFEASHGPIKA 849
+I + P N TT I+ P P + + N+V V + P+
Sbjct: 561 FTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQTDNTVTVMLKPAHSRGAPVSV 620
Query: 850 YAVILTTGEAGHP--SADVLK-YTYEDFKKGASDTYVTYLIRTEEKGRSQSLSEVLKYEI 906
Y +++ + ++LK Y + AS Y E S ++
Sbjct: 621 YQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYYFAAEFPADSLQAAQ----PF 676
Query: 907 DVGNESTTLGYYNGKLEPLGSYRACVAGFTNITFHPQNKGLIDGAESYVSFSRYSDAVSL 966
+G+ T GY+N L P SYR + + ID + + V
Sbjct: 677 TIGDNKTYNGYWNTPLLPYKSYRI----YFQAASRANGETKIDCVQVATKGAATPKPVPE 732
Query: 967 PQDPGVICGAVFGCIFGALVIVTVG-GFIFWRKKRKDAKNNEVSFSQIKPKKSKLIRVEN 1025
P+ + G I G L+ V + G + KKRK AK + + S + + + + V +
Sbjct: 733 PEKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKETMSSTRQEMT--VMVNS 790
Query: 1026 FEAYFKKQQADSNCGFAEEYED 1047
+ + +Q +NC A + D
Sbjct: 791 MDKSYAEQ--GTNCDEAFSFMD 810
Score = 33.1 bits (74), Expect = 1.8
Identities = 39/168 (23%), Positives = 71/168 (42%), Gaps = 29/168 (17%)
Query: 321 SGQQSR---DTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTN----AIQVFDV- 372
SG+ S+ +T L GL PGT Y+ T+ + A G G P +F T ++ +++
Sbjct: 536 SGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGF-GPPATNQFTTKISAPSMPAYELE 594
Query: 373 TAVNISATSLTLIWKVSDNESSSNYTYKIHVAGETDSSNLNVSEPRAVIP--------GL 424
T +N + ++T++ K + + + Y+I V E +E P L
Sbjct: 595 TPLNQTDNTVTVMLKPAHSRGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASL 654
Query: 425 RSSTFYNITVCP----------VLGDIEGTPGFLQVHTPPVPVSDFRV 462
+S +Y P +GD + G+ +TP +P +R+
Sbjct: 655 LNSQYYFAAEFPADSLQAAQPFTIGDNKTYNGYW--NTPLLPYKSYRI 700
>gi|157419152 protein tyrosine phosphatase, receptor type, M isoform 1
precursor [Homo sapiens]
Length = 1465
Score = 244 bits (624), Expect = 3e-64
Identities = 129/279 (46%), Positives = 170/279 (60%), Gaps = 7/279 (2%)
Query: 1021 IRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDIS 1080
IRV + + + + GF EEYE G S P +A+ ENR KNRY N++ YD S
Sbjct: 893 IRVADLLQHITQMKCAEGYGFKEEYESF-FEGQSAPWDSAKKDENRMKNRYGNIIAYDHS 951
Query: 1081 RVKL-SVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLT 1139
RV+L +++ + DYIN NY+ GYH +IATQGP+ T+ DFWRMVW +N +IIM+T
Sbjct: 952 RVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVT 1011
Query: 1140 KCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFH 1199
VE GR KC +YWP + Y DI V + +L E+ IR F V+ E +RQFH
Sbjct: 1012 NLVEVGRVKCCKYWPD-DTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFH 1070
Query: 1200 FTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPES-PILVHCSAGVGRTGTFIAIDRLIYQ 1258
FT WPDHGVP L+ F VR +SPP + P++VHCSAG GRTG FI ID ++
Sbjct: 1071 FTGWPDHGVPYHATGLLGF---VRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDM 1127
Query: 1259 IENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLD 1297
E E VD+Y V +LR R MVQTE+QYVF++ +L+
Sbjct: 1128 AEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILE 1166
Score = 125 bits (314), Expect = 3e-28
Identities = 88/285 (30%), Positives = 133/285 (46%), Gaps = 16/285 (5%)
Query: 1029 YFKKQQADSNCGFAEEYEDLKLVGISQPKYAAE------LAENRGKNRYNNVLPYDISRV 1082
Y+ + D ++ E+ + + + P E L N KNR ++LP D
Sbjct: 1184 YYDMNKLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLP 1243
Query: 1083 KLSVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCV 1142
L + +YINA M Y FI TQ PLPNT+KDFWR+V + + +++ML V
Sbjct: 1244 FLITIDGESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLND-V 1302
Query: 1143 EQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSES--HPLRQFHF 1200
+ + C +YWP +G I V S + + R F + N + ++QF F
Sbjct: 1303 DPAQL-CPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGYRMVQQFQF 1361
Query: 1201 TSWPDHGVPDTTDLLINFRYLVRDYMK----QSPPESPILVHCSAGVGRTGTFIAIDRLI 1256
WP + DT +F L+R K + E +VHC G GR+GTF AI +
Sbjct: 1362 LGWPMY--RDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVC 1419
Query: 1257 YQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRS 1301
+ ++ TVDV+ V LR ++P MV DQY F + L+ + S
Sbjct: 1420 EMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNS 1464
Score = 47.0 bits (110), Expect = 1e-04
Identities = 132/622 (21%), Positives = 222/622 (35%), Gaps = 109/622 (17%)
Query: 448 LQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDAESFQ----------MHITQEGAGNSRVE 497
L V PPVP++ ++ V T + W +A S + T G+ N R
Sbjct: 276 LVVKEPPVPIAPPQLASVGATYL---WIQLNANSINGDGPIVAREVEYCTASGSWNDRQP 332
Query: 498 ITTNQSIIIGGLFPGTKYCFEIV----PKGPNGTEGAS---RTVCNRTVPSAVFDIHVVY 550
+ + S IG L P T+Y ++ +G G+ G + RT C + + VV
Sbjct: 333 VDST-SYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRTKCADPMRGPR-KLEVVE 390
Query: 551 VTTTEMWLDWKSPDGASEYVYHLVIESKHGSNHTSTYDKAITLQGLIPGTLYNITISPEV 610
V + ++ + W+ P G + + H N T Y + Q + EV
Sbjct: 391 VKSRQITIRWE-PFGYN-------VTRCHSYNLTVHYCYQVGGQE---------QVREEV 433
Query: 611 DHVWGDPNSTAQYTRPSNVSNIDVSTNTTAATLSWQNFDDASPTYSYCLLIEKAGNSSNA 670
W NS Q+T ++N+ TN + + L+ + S
Sbjct: 434 S--WDTENSHPQHT----ITNLSPYTNVSVKLI---------------LMNPEGRKESQE 472
Query: 671 TQVVTDIGITDATVTELIPGSSYTVEIFAQVGDGIKSLEPGRKSFCTDPASMASFDCEVV 730
V TD + A TE I GS++ +IF Q + ++ T A ++SFD E+
Sbjct: 473 LIVQTDEDLPGAVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKA-VSSFDPEI- 530
Query: 731 PKEPALVLKWTCPPGANAGFELEVSSGAWNNATHLESCSSENGTEYRTEVTYLNFSTSYN 790
+L SG S+ G E L T+Y+
Sbjct: 531 --------------------DLSNQSGR----------VSKLGNETHFLFFGLYPGTTYS 560
Query: 791 ISITTVSCGKMAAPTRNTCTTGITDPPPPDGSPNIT-SVSHNSVKVKFSGFEASHGPIKA 849
+I + P N TT I+ P P + + N+V V + P+
Sbjct: 561 FTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQTDNTVTVMLKPAHSRGAPVSV 620
Query: 850 YAVILTTGEAGHP--SADVLK-YTYEDFKKGASDTYVTYLIRTEEKGRSQSLSEVLKYEI 906
Y +++ + ++LK Y + AS Y E S ++
Sbjct: 621 YQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYYFAAEFPADSLQAAQ----PF 676
Query: 907 DVGNESTTLGYYNGKLEPLGSYRACVAGFTNITFHPQNKGLIDGAESYVSFSRYSDAVSL 966
+G+ T GY+N L P SYR + + ID + + V
Sbjct: 677 TIGDNKTYNGYWNTPLLPYKSYRI----YFQAASRANGETKIDCVQVATKGAATPKPVPE 732
Query: 967 PQDPGVICGAVFGCIFGALVIVTVG-GFIFWRKKRKDAKNNEVSFSQIKPKKSKLIRVEN 1025
P+ + G I G L+ V + G + KKRK AK + + S + + + + V +
Sbjct: 733 PEKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKETMSSTRQEMT--VMVNS 790
Query: 1026 FEAYFKKQQADSNCGFAEEYED 1047
+ + +Q +NC A + D
Sbjct: 791 MDKSYAEQ--GTNCDEAFSFMD 810
Score = 33.1 bits (74), Expect = 1.8
Identities = 39/168 (23%), Positives = 71/168 (42%), Gaps = 29/168 (17%)
Query: 321 SGQQSR---DTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTN----AIQVFDV- 372
SG+ S+ +T L GL PGT Y+ T+ + A G G P +F T ++ +++
Sbjct: 536 SGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGF-GPPATNQFTTKISAPSMPAYELE 594
Query: 373 TAVNISATSLTLIWKVSDNESSSNYTYKIHVAGETDSSNLNVSEPRAVIP--------GL 424
T +N + ++T++ K + + + Y+I V E +E P L
Sbjct: 595 TPLNQTDNTVTVMLKPAHSRGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASL 654
Query: 425 RSSTFYNITVCP----------VLGDIEGTPGFLQVHTPPVPVSDFRV 462
+S +Y P +GD + G+ +TP +P +R+
Sbjct: 655 LNSQYYFAAEFPADSLQAAQPFTIGDNKTYNGYW--NTPLLPYKSYRI 700
>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
isoform 2 precursor [Homo sapiens]
Length = 1910
Score = 243 bits (621), Expect = 7e-64
Identities = 276/1097 (25%), Positives = 449/1097 (40%), Gaps = 174/1097 (15%)
Query: 328 TEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRT----NAIQVFDVTAVNISATSLT 383
T ++ L+P T Y + +++ G + RT + DV V++ +T++
Sbjct: 564 TSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAIL 623
Query: 384 LIWKVSDNESSSN----YTYKIHVAGETDSSNLNVS-----EPRAVIPGLRSSTFYNITV 434
+ W+ E+ + Y+ + G D V+ + ++ L T Y IT
Sbjct: 624 VSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITT 683
Query: 435 CP---VLGDIEGTPGFLQVH--TPPVPVSDFRVTVVSTTEIGLAWSSH-------DAESF 482
V E +P ++ P P ++ T I + W S +
Sbjct: 684 VAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGY 743
Query: 483 QMH-ITQEGA---GNSRVE---ITTNQSIIIGGLFPGTKYCFEIVP---KGPNGTEGASR 532
Q+H + EGA G R++ + Q ++I L P T Y + KG +G +
Sbjct: 744 QVHYVRMEGAEARGPPRIKDVMLADAQEMVITNLQPETAYSITVAAYTMKG-DGARSKPK 802
Query: 533 TVCNRTVPSAVFDIHVVYVTTTEMWLDWKSPDGASE---YVYHLVIESKHGSNHTSTYD- 588
V + + V + W+ P G +E Y L + S +T +
Sbjct: 803 VVVTKGAVLGRPTLSVQQTPEGSLLARWEPPAGTAEDQVLGYRLQF-GREDSTPLATLEF 861
Query: 589 ----KAITLQGLIPGTLYNITISPEVDHVWGDPN----STAQYTRPSNVSNIDVSTNTTA 640
T G+ G Y ++ G+ S + T + ++ + N +A
Sbjct: 862 PPSEDRYTASGVHKGATYVFRLAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASA 921
Query: 641 AT--LSWQNFDDASPT---YSYCLLIEKAGNSSNATQV----VTDIGITDA-TVTELIPG 690
T L W A Y + + +AG A + + G +A T+ L P
Sbjct: 922 GTVLLRWLPPVPAERNGAIVKYTVAVREAGALGPARETELPAAAEPGAENALTLQGLKPD 981
Query: 691 SSYTVEIFAQVGDGIKSLEPG--RKSFCTDPASMASFDCEVVPKEPALVLKWTCPPGANA 748
++Y +++ A G P ++F D S +F +++ K L L W P N+
Sbjct: 982 TAYDLQVRAHTRRGPGPFSPPVRYRTFLRDQVSPKNFKVKMIMKTSVL-LSWEFPDNYNS 1040
Query: 749 GFELEVSSGAWNNATHLESCSSENGTEYRTEVTYLNFSTSYNISITTVSCGKMAAPTRNT 808
++ +N T +G + +T+L T YN +T + G + T
Sbjct: 1041 PTPYKIQ---YNGLT-----LDVDGRTTKKLITHLKPHTFYNFVLT--NRGSSLGGLQQT 1090
Query: 809 CTTGITDPPPPDGSPNITSVSHNSVKVKFSGF-------EASHGPIKAYAVILTTGEAGH 861
T T +G P++ K GF S P+++Y +++
Sbjct: 1091 VTAW-TAFNLLNGKPSVAP------KPDADGFIMVYLPDGQSPVPVQSYFIVMVP----- 1138
Query: 862 PSADVLKYTYEDFKKGASDTYVTYLIRTEEKGRSQSLSEVLKYEIDVGNESTTLGYYNGK 921
+K ++T L E+ L E+++ D+ ++ +
Sbjct: 1139 ------------LRKSRGGQFLTPLGSPED----MDLEELIQ---DISRLQRRSLRHSRQ 1179
Query: 922 LEPLGSYRACVAGFTNITFHP---------QNKGLIDGAESYVSF--------------S 958
LE Y A TFHP N+GL G YV F S
Sbjct: 1180 LEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPG-HRYVLFVLAVLQKSEPTFAAS 1238
Query: 959 RYSDAVSL--PQDPGVICGA-----VFGCIFGALVIVTVGGFIFWRKKRKDAKN------ 1005
+SD L P ++ G V G + + I+ + I K + D+K
Sbjct: 1239 PFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPR 1298
Query: 1006 -----NEVSFSQIKPKKSKLIRVENFEA----------------YFKKQQADSNCGFAEE 1044
N + PK +R NF+ + ++ +A+ + ++E
Sbjct: 1299 TKCLLNNADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQE 1358
Query: 1045 YEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLS-VQTHSTDDYINANYMPGY 1103
YE + G + L N+ KNRY NV+ YD SRV L ++ DYINANY+ GY
Sbjct: 1359 YESID-PGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGY 1417
Query: 1104 HSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYGD 1163
+ +IATQGPLP T DFWRMVWE+ I+M+T+ E+ R KC++YWP++ + YG
Sbjct: 1418 RCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGF 1477
Query: 1164 ITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVR 1223
I V + I L + +R F++ +SE +RQF FT+WPDHGVP+ + F +R
Sbjct: 1478 IQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAF---LR 1534
Query: 1224 DYMKQSPPES-PILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMV 1282
+PP++ PI+VHCSAGVGRTG FI ID ++ +I+ E TVDVYG V +R R MV
Sbjct: 1535 RVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMV 1594
Query: 1283 QTEDQYVFLNQCVLDIV 1299
QTEDQY F+++ +L+ V
Sbjct: 1595 QTEDQYSFIHEALLEAV 1611
Score = 210 bits (534), Expect = 8e-54
Identities = 104/244 (42%), Positives = 152/244 (62%), Gaps = 1/244 (0%)
Query: 1059 AAELAENRGKNRYNNVLPYDISRVKLS-VQTHSTDDYINANYMPGYHSKKDFIATQGPLP 1117
+A L N+ KNR N++PY+ +RV L ++ DYINA+++ GY +K +IATQGPL
Sbjct: 1661 SANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLA 1720
Query: 1118 NTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEW 1177
T +DFWRM+WE N ++MLTK E GR KC +YWP++++ Y V +E +P++
Sbjct: 1721 ETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQY 1780
Query: 1178 TIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILV 1237
+R+F V + + +S +RQF FT WP+ GVP + + I+F V +Q + PI V
Sbjct: 1781 ILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISV 1840
Query: 1238 HCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLD 1297
HCSAGVGRTG FI + ++ ++ E VD++ V LR RP MVQTED+Y F Q L+
Sbjct: 1841 HCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALE 1900
Query: 1298 IVRS 1301
+ S
Sbjct: 1901 YLGS 1904
Score = 48.5 bits (114), Expect = 4e-05
Identities = 107/472 (22%), Positives = 176/472 (37%), Gaps = 62/472 (13%)
Query: 328 TEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTN----AIQVFDVTAVNISATSLT 383
T + GL P + Y V + + G +++ RT A +V A +SAT++
Sbjct: 372 TRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMI 431
Query: 384 LIWKVSDNESSSNYTYKI-------HVAGETDSSNLNVSEPRAVIPGLRSSTFYNITVCP 436
+ W+ + Y++ H G N++ S V L T Y + V
Sbjct: 432 VQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDET-YTVRVLA 490
Query: 437 VLGDIEGTPGF-LQVHTP---PVPVSDFRVTVVSTTEIGLAWSSHDAESFQMH--ITQEG 490
+G +QV T P + R S T I L+WS ES + + +EG
Sbjct: 491 FTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREG 550
Query: 491 AGNSRVEITTNQ--SIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTV---PSA-VF 544
V T + S ++ L P T+Y F + + P G + V RT+ PSA
Sbjct: 551 DHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQ 610
Query: 545 DIHVVYVTTTEMWLDWKSPDGASE---YVYHLVIESKHGS--------NHTSTYDKAITL 593
D+ V V +T + + W+ P + V + V GS N I L
Sbjct: 611 DVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILL 670
Query: 594 QGLIPGTLYNITISPEVDHVWGDPNSTAQYTRPSNVSNID------VSTNTTAATLSWQN 647
+ L T Y IT + G +S +V + + N TA + W++
Sbjct: 671 EALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRS 730
Query: 648 FDDASPTYSYCLL-------IEKAGNSSNATQVVTDIGITDA---TVTELIPGSSY--TV 695
+P + + + G + + D+ + DA +T L P ++Y TV
Sbjct: 731 ---PAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQEMVITNLQPETAYSITV 787
Query: 696 EIFAQVGDGIKSLEPGRKSFCTDPASMA--SFDCEVVPKEPALVLKWTCPPG 745
+ GDG +S K T A + + + P E +L+ +W P G
Sbjct: 788 AAYTMKGDGARSKP---KVVVTKGAVLGRPTLSVQQTP-EGSLLARWEPPAG 835
Score = 44.3 bits (103), Expect = 8e-04
Identities = 46/197 (23%), Positives = 77/197 (39%), Gaps = 39/197 (19%)
Query: 305 TAPVHDESLVGPVD----PSSGQQSRDTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAI 360
T V + +GP P++ + + + L GL+P T Y+ V + G +
Sbjct: 944 TVAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPV 1003
Query: 361 EFRT---NAIQVFDVTAVNISATSLTLIWKVSDNESSSNYTYKIHVAGETDSSNLNVSEP 417
+RT + + + I TS+ L W+ DN +S YKI G T +++
Sbjct: 1004 RYRTFLRDQVSPKNFKVKMIMKTSVLLSWEFPDNYNSPT-PYKIQYNGLT--LDVDGRTT 1060
Query: 418 RAVIPGLRSSTFYN----------------ITVCPVLGDIEGTP---------GFLQVHT 452
+ +I L+ TFYN +T + G P GF+ V+
Sbjct: 1061 KKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYL 1120
Query: 453 P----PVPVSDFRVTVV 465
P PVPV + + +V
Sbjct: 1121 PDGQSPVPVQSYFIVMV 1137
Score = 31.2 bits (69), Expect = 7.0
Identities = 97/474 (20%), Positives = 170/474 (35%), Gaps = 82/474 (17%)
Query: 36 AGGTPSPIPDPSVATVATGENGITQ-ISSTAESFHKQNGTGTPQVE-----TNTSEDGES 89
A GTP + + + T ++G +S + ++ G Q++ T S G S
Sbjct: 321 APGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLS 380
Query: 90 SGANDSLRTPEQGSNGTDGASQKTPSSTGP----SPVFDIKAVSISPTNVILTWKSNDTA 145
+ + S G S+ + TG S +++A +S T +I+ W+
Sbjct: 381 PNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEP 440
Query: 146 ASEYK-YVVKHKMENEKTI------TVVHQPWCNITGLRPATSYVFSITP--GIGNETWG 196
+ Y V + ME E + V + L +Y + +G+
Sbjct: 441 NGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLS 500
Query: 197 DPRVIKVITE---PIPVSDLRVALTGVRKAALSWSNGNGTASCRV-LLESIGSHEE---L 249
DP I+V T+ P +LR LSWS + + LL G H
Sbjct: 501 DP--IQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGREVGR 558
Query: 250 TQDSRLQVNISGLKPGVQYNINPYLLQSNKTKGDPLGTEGGLDASNTERSRAGSPTAPV- 308
T D + LKP +Y + L + +G LG + T +S+ +P V
Sbjct: 559 TFDPTTSYVVEDLKPNTEY---AFRLAARSPQG--LGAFTPVVRQRTLQSKPSAPPQDVK 613
Query: 309 --------------------HDESLVG---------PVDPS----SGQQSRDTEVLLVGL 335
H+ +LVG DP +G T++LL L
Sbjct: 614 CVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEAL 673
Query: 336 EPGTRYNATVYSQAANGTEGQPQAIEFRTN----AIQVFDVTAVNISATSLTLIWK--VS 389
E T+Y T + G + + RT+ + V A ++AT++ ++W+
Sbjct: 674 EKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAP 733
Query: 390 DNESSSNYTYKIH--------VAGETDSSNLNVSEPR-AVIPGLRSSTFYNITV 434
+ Y++H G ++ +++ + VI L+ T Y+ITV
Sbjct: 734 GRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQEMVITNLQPETAYSITV 787
>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform 2
precursor [Homo sapiens]
Length = 1898
Score = 239 bits (611), Expect = 1e-62
Identities = 320/1321 (24%), Positives = 534/1321 (40%), Gaps = 184/1321 (13%)
Query: 119 PSPVFDIKAVSISPTNVILTWKSNDTAASEYKYVVKHKMENEK----TITVVHQPWCNIT 174
P P D+ + T+V LTW S ++ Y Y ++++ + + V +I
Sbjct: 319 PKPPIDLVVTETTATSVTLTWDSGNSEPVTY-YGIQYRAAGTEGPFQEVDGVATTRYSIG 377
Query: 175 GLRPATSYVFSITPGIGNETWGDP-RVIKVIT-EPIPVSDLRVALTGVRKAA---LSWS- 228
GL P + Y F + + + G P ++ T E P S R + A+ + W
Sbjct: 378 GLSPFSEYAFRVL-AVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEP 436
Query: 229 --NGNGTASCRVLLESIGS-------HEELTQDSRLQVNISGLKPGVQYNINPYLLQSNK 279
NG + + S H+ T D+ L + L PG+ Y++ L +
Sbjct: 437 PEEPNGLVRGYRVYYTPDSRRPPNAWHKHNT-DAGLLTTVGSLLPGITYSLR-VLAFTAV 494
Query: 280 TKGDP-----LGTEGGLDASNTERSRAGSPTAPVHDESLVGPVD------------PSSG 322
G P + T+ G+ A + + L+ P +
Sbjct: 495 GDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERIIMYELVYWAAEDED 554
Query: 323 QQSRDT-----EVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTN----AIQVFDVT 373
QQ + T L L+P T Y + +++ G IE RT + V
Sbjct: 555 QQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVM 614
Query: 374 AVNISATSLTLIWKVSDNESSSNYTYKIHVA-----GETDSSNL--NVSEPRAV--IPGL 424
V++ +T++ + W +S + + VA GE ++ +S + + GL
Sbjct: 615 CVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGL 674
Query: 425 RSSTFYNITV---CPVLGDIEGTPGFLQVH--TPPVPVSDFRVTVVSTTEIGLAWS---- 475
T Y + V V E +P ++ P P V +++T + + W
Sbjct: 675 EKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVP 734
Query: 476 ---SHDAESFQMHITQEGAGNSR-------VEITTNQSIIIGGLFPGTKYCFEIVPKGPN 525
+Q+ + G R V + Q I GL P T Y +
Sbjct: 735 SKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQETTISGLTPETTYSVTVAAYTTK 794
Query: 526 GTEGASRTVCNRTVPSAVFDIHVVYVTTTEM---WLDWKSPDGASEYV------YHLVIE 576
G +GA T AV + ++TT M L W P + Y E
Sbjct: 795 G-DGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQWHPPKELPGELLGYRLQYCRADE 853
Query: 577 SKHGSNHTSTYDKAITLQGLIPGTLYNITISPEVDHVWGDPNSTAQYTR---PSNV-SNI 632
++ + D+ T+ GL GT Y ++ + G+ T PS N+
Sbjct: 854 ARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNL 913
Query: 633 DVSTNTTAAT-LSWQN---FDDASPTYSYCLLIEKAGNSSNATQVVTDIGITDATVTELI 688
V+ TT+ T L+W + SY ++ + + TD T T+T L
Sbjct: 914 HVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQELQNITTD---TRFTLTGLK 970
Query: 689 PGSSYTVEIFAQVGDGIKSLEPGRKSFCTDPASMASFDCEVVPK-EPALVLKWTCPPGAN 747
P ++Y +++ A G L P +S + + + V + +++L W P
Sbjct: 971 PDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMKTSVLLSWEVPDSYK 1030
Query: 748 AGFELEVSSGAWNNATHLESCSSENGTEYRTEVTYLNFSTSYNISITTVSCGKMAAPTRN 807
+ ++ N +E +G R + L +T Y S ++ G A ++
Sbjct: 1031 SAVPFKILY----NGQSVEV----DGHSMRKLIADLQPNTEY--SFVLMNRGSSAGGLQH 1080
Query: 808 -----TCTTGITDPPPP------DGSPNITSVSHNSVKVKFSGFEASHGPIKAYAVILTT 856
T + P P DG ++ S+ H F PI + T
Sbjct: 1081 LVSIRTAPDLLPHKPLPASAYIEDGRFDL-SMPHVQDPSLVRWFYIVVVPIDRVGGSMLT 1139
Query: 857 GEAGHPSADVLKYTYEDFKKGASDTYVTYLIRTEEKGRSQSLSEVLKYEIDVGNESTTLG 916
P L E ++G + + + +++ L + ++DV E+ TLG
Sbjct: 1140 PRWSTPEELELDELLEAIEQGGEE-------QRRRRRQAERLKPYVAAQLDVLPETFTLG 1192
Query: 917 -------YYNGKLEPLGSYRACVAGFTNITFHPQNKGLIDGAESYVSFSRYSDAVSLPQD 969
+YN L P SY+ V P ++ + Y S S YSD + +
Sbjct: 1193 DKKNYRGFYNRPLSPDLSYQCFVLASLK---EPMDQ------KRYAS-SPYSDEIVVQVT 1242
Query: 970 PGV---------ICGAVFGCIFGALVIVTVGGFIFWRKKR-----KDA-----KNNEVSF 1010
P + G V I L+++ + +F RK+ KD K++ ++
Sbjct: 1243 PAQQQEEPEMLWVTGPVLAVILIILIVIAI--LLFKRKRTHSPSSKDEQSIGLKDSLLAH 1300
Query: 1011 SQIKPKKSKL------------IRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQPKY 1058
S + +L I + + ++ +A+ F++EYE + G
Sbjct: 1301 SSDPVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESID-PGQQFTWE 1359
Query: 1059 AAELAENRGKNRYNNVLPYDISRVKL-SVQTHSTDDYINANYMPGYHSKKDFIATQGPLP 1117
+ L N+ KNRY NV+ YD SRV L S+ DYINANY+ GY + +IATQGPLP
Sbjct: 1360 NSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLP 1419
Query: 1118 NTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEW 1177
T+ DFWRMVWE+ ++M+T+ E+ R KC++YWP++ + G I V + + L +
Sbjct: 1420 ETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATY 1479
Query: 1178 TIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPES-PIL 1236
T+R F + +SE LRQF F +WPDHGVP+ ++ F +R +P ++ P++
Sbjct: 1480 TVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAF---LRRVKACNPLDAGPMV 1536
Query: 1237 VHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVL 1296
VHCSAGVGRTG FI ID ++ ++++E TVD+YG V +R R MVQTEDQYVF+++ +L
Sbjct: 1537 VHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALL 1596
Query: 1297 D 1297
+
Sbjct: 1597 E 1597
Score = 210 bits (534), Expect = 8e-54
Identities = 104/244 (42%), Positives = 152/244 (62%), Gaps = 1/244 (0%)
Query: 1059 AAELAENRGKNRYNNVLPYDISRVKLS-VQTHSTDDYINANYMPGYHSKKDFIATQGPLP 1117
+A L N+ KNR N++PY+++RV L ++ DYINA+++ GY +K +IATQGPL
Sbjct: 1649 SANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLA 1708
Query: 1118 NTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEW 1177
+ +DFWRM+WE N I+MLTK E GR KC +YWP++++ Y V +E +P++
Sbjct: 1709 ESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQY 1768
Query: 1178 TIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILV 1237
+R+F V + + +S +RQF FT WP+ GVP T + I+F V +Q + PI V
Sbjct: 1769 ILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITV 1828
Query: 1238 HCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLD 1297
HCSAGVGRTG FI + ++ ++ E VD++ V LR RP MVQTEDQY + L+
Sbjct: 1829 HCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALE 1888
Query: 1298 IVRS 1301
+ S
Sbjct: 1889 YLGS 1892
Score = 52.8 bits (125), Expect = 2e-06
Identities = 105/478 (21%), Positives = 166/478 (34%), Gaps = 56/478 (11%)
Query: 427 STFYNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDAESFQMH- 485
S Y LG IE T + V P P D VT + T + L W S ++E +
Sbjct: 293 SANYTCVAISSLGMIEATAQ-VTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYG 351
Query: 486 ITQEGAGN----SRVEITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTVPS 541
I AG V+ IGGL P ++Y F ++ G S V RT
Sbjct: 352 IQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQ 411
Query: 542 AVFD----IHVVYVTTTEMWLDWKSPDGAS----EYVYHLVIESKHGSN----HTSTYDK 589
A + ++ + M + W+ P+ + Y + +S+ N H +
Sbjct: 412 APSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGL 471
Query: 590 AITLQGLIPGTLYNITISPEVDHVWGDPNSTAQYTR----PSNVSNIDVSTNT-TAATLS 644
T+ L+PG Y++ + G P+ T Q P+ ++ + T LS
Sbjct: 472 LTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLS 531
Query: 645 WQNFDDASPTYSYCLLIEK---AGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQV 701
W P ++ E A + VT + T+ +L P + Y ++ A+
Sbjct: 532 W-----LLPPQERIIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARS 586
Query: 702 GDGIKSLEP---GRKSFCTDPASMASFDCEVVPKEPALVLKWTCPPGANAGFELEVSSGA 758
G+ P R + T A C V + + W PP + + S A
Sbjct: 587 DMGVGVFTPTIEARTAQSTPSAPPQKVMC-VSMGSTTVRVSWVPPPADSRNGVITQYSVA 645
Query: 759 W------NNATHLESCSSENGTEYRTEVTYLNFSTSYNISI---TTVSCGKMAAPTRNTC 809
+ + H+ S + + ++ L T Y + + T V G ++P
Sbjct: 646 YEAVDGEDRGRHVVDGISREHSSW--DLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVR- 702
Query: 810 TTGITDPPPPDGSPNITSVSH-NSVKV----KFSGFEASHGPIKAYAVILTTGEAGHP 862
TD P G P V NS V K HG I+ Y V E G P
Sbjct: 703 ----TDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEP 756
>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform 1
precursor [Homo sapiens]
Length = 1907
Score = 238 bits (608), Expect = 2e-62
Identities = 235/872 (26%), Positives = 380/872 (43%), Gaps = 107/872 (12%)
Query: 495 RVEITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTVPSAVFDIHVVYVTTT 554
R E + + I GL P T Y + G +GA T AV + ++TT
Sbjct: 773 RPEESEDYETTISGLTPETTYSVTVAAYTTKG-DGARSKPKIVTTTGAVPGRPTMMISTT 831
Query: 555 EM---WLDWKSPDGASEYV------YHLVIESKHGSNHTSTYDKAITLQGLIPGTLYNIT 605
M L W P + Y E++ + D+ T+ GL GT Y
Sbjct: 832 AMNTALLQWHPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFR 891
Query: 606 ISPEVDHVWGDPNSTAQYTR---PSNV-SNIDVSTNTTAAT-LSWQN---FDDASPTYSY 657
++ + G+ T PS N+ V+ TT+ T L+W + SY
Sbjct: 892 LAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISY 951
Query: 658 CLLIEKAGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQVGDGIKSLEPGRKSFCT 717
++ + + TD T T+T L P ++Y +++ A G L P +S
Sbjct: 952 TVVFRDINSQQELQNITTD---TRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTM 1008
Query: 718 DPASMASFDCEVVPK-EPALVLKWTCPPGANAGFELEVSSGAWNNATHLESCSSENGTEY 776
+ + + V + +++L W P + ++ N +E +G
Sbjct: 1009 PVEQVFAKNFRVAAAMKTSVLLSWEVPDSYKSAVPFKILY----NGQSVEV----DGHSM 1060
Query: 777 RTEVTYLNFSTSYNISITTVSCGKMAAPTRN-----TCTTGITDPPPP------DGSPNI 825
R + L +T Y S ++ G A ++ T + P P DG ++
Sbjct: 1061 RKLIADLQPNTEY--SFVLMNRGSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDL 1118
Query: 826 TSVSHNSVKVKFSGFEASHGPIKAYAVILTTGEAGHPSADVLKYTYEDFKKGASDTYVTY 885
S+ H F PI + T P L E ++G +
Sbjct: 1119 -SMPHVQDPSLVRWFYIVVVPIDRVGGSMLTPRWSTPEELELDELLEAIEQGGEE----- 1172
Query: 886 LIRTEEKGRSQSLSEVLKYEIDVGNESTTLG-------YYNGKLEPLGSYRACVAGFTNI 938
+ + +++ L + ++DV E+ TLG +YN L P SY+ V
Sbjct: 1173 --QRRRRRQAERLKPYVAAQLDVLPETFTLGDKKNYRGFYNRPLSPDLSYQCFVLASLK- 1229
Query: 939 TFHPQNKGLIDGAESYVSFSRYSDAVSLPQDPGV---------ICGAVFGCIFGALVIVT 989
P ++ + Y S S YSD + + P + G V I L+++
Sbjct: 1230 --EPMDQ------KRYAS-SPYSDEIVVQVTPAQQQEEPEMLWVTGPVLAVILIILIVIA 1280
Query: 990 VGGFIFWRKKR-----KDA-----KNNEVSFSQIKPKKSKL------------IRVENFE 1027
+ +F RK+ KD K++ ++ S + +L I + +
Sbjct: 1281 I--LLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMRDHPPIPITDLA 1338
Query: 1028 AYFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKL-SV 1086
++ +A+ F++EYE + G + L N+ KNRY NV+ YD SRV L S+
Sbjct: 1339 DNIERLKANDGLKFSQEYESID-PGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSI 1397
Query: 1087 QTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGR 1146
DYINANY+ GY + +IATQGPLP T+ DFWRMVWE+ ++M+T+ E+ R
Sbjct: 1398 DGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSR 1457
Query: 1147 TKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDH 1206
KC++YWP++ + G I V + + L +T+R F + +SE LRQF F +WPDH
Sbjct: 1458 VKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDH 1517
Query: 1207 GVPDTTDLLINFRYLVRDYMKQSPPES-PILVHCSAGVGRTGTFIAIDRLIYQIENENTV 1265
GVP+ ++ F +R +P ++ P++VHCSAGVGRTG FI ID ++ ++++E TV
Sbjct: 1518 GVPEYPTPILAF---LRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTV 1574
Query: 1266 DVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLD 1297
D+YG V +R R MVQTEDQYVF+++ +L+
Sbjct: 1575 DIYGHVTCMRSQRNYMVQTEDQYVFIHEALLE 1606
Score = 210 bits (534), Expect = 8e-54
Identities = 104/244 (42%), Positives = 152/244 (62%), Gaps = 1/244 (0%)
Query: 1059 AAELAENRGKNRYNNVLPYDISRVKLS-VQTHSTDDYINANYMPGYHSKKDFIATQGPLP 1117
+A L N+ KNR N++PY+++RV L ++ DYINA+++ GY +K +IATQGPL
Sbjct: 1658 SANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLA 1717
Query: 1118 NTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEW 1177
+ +DFWRM+WE N I+MLTK E GR KC +YWP++++ Y V +E +P++
Sbjct: 1718 ESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQY 1777
Query: 1178 TIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILV 1237
+R+F V + + +S +RQF FT WP+ GVP T + I+F V +Q + PI V
Sbjct: 1778 ILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITV 1837
Query: 1238 HCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLD 1297
HCSAGVGRTG FI + ++ ++ E VD++ V LR RP MVQTEDQY + L+
Sbjct: 1838 HCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALE 1897
Query: 1298 IVRS 1301
+ S
Sbjct: 1898 YLGS 1901
Score = 52.8 bits (125), Expect = 2e-06
Identities = 105/478 (21%), Positives = 166/478 (34%), Gaps = 56/478 (11%)
Query: 427 STFYNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDAESFQMH- 485
S Y LG IE T + V P P D VT + T + L W S ++E +
Sbjct: 293 SANYTCVAISSLGMIEATAQ-VTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYG 351
Query: 486 ITQEGAGN----SRVEITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTVPS 541
I AG V+ IGGL P ++Y F ++ G S V RT
Sbjct: 352 IQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQ 411
Query: 542 AVFD----IHVVYVTTTEMWLDWKSPDGAS----EYVYHLVIESKHGSN----HTSTYDK 589
A + ++ + M + W+ P+ + Y + +S+ N H +
Sbjct: 412 APSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGL 471
Query: 590 AITLQGLIPGTLYNITISPEVDHVWGDPNSTAQYTR----PSNVSNIDVSTNT-TAATLS 644
T+ L+PG Y++ + G P+ T Q P+ ++ + T LS
Sbjct: 472 LTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLS 531
Query: 645 WQNFDDASPTYSYCLLIEK---AGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQV 701
W P ++ E A + VT + T+ +L P + Y ++ A+
Sbjct: 532 W-----LLPPQERIIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARS 586
Query: 702 GDGIKSLEP---GRKSFCTDPASMASFDCEVVPKEPALVLKWTCPPGANAGFELEVSSGA 758
G+ P R + T A C V + + W PP + + S A
Sbjct: 587 DMGVGVFTPTIEARTAQSTPSAPPQKVMC-VSMGSTTVRVSWVPPPADSRNGVITQYSVA 645
Query: 759 W------NNATHLESCSSENGTEYRTEVTYLNFSTSYNISI---TTVSCGKMAAPTRNTC 809
+ + H+ S + + ++ L T Y + + T V G ++P
Sbjct: 646 YEAVDGEDRGRHVVDGISREHSSW--DLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVR- 702
Query: 810 TTGITDPPPPDGSPNITSVSH-NSVKV----KFSGFEASHGPIKAYAVILTTGEAGHP 862
TD P G P V NS V K HG I+ Y V E G P
Sbjct: 703 ----TDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEP 756
Score = 50.4 bits (119), Expect = 1e-05
Identities = 128/601 (21%), Positives = 219/601 (36%), Gaps = 81/601 (13%)
Query: 371 DVTAVNISATSLTLIWKVSDNESSSNYTYKIHVAG------ETDSSNLNVSEPRAVIPGL 424
D+ +ATS+TL W ++E + Y + AG E D V+ R I GL
Sbjct: 324 DLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTEGPFQEVD----GVATTRYSIGGL 379
Query: 425 RSSTFYNITVCPVLGDIEGTPG-FLQVHT----PPVPVSDFRVTVVSTTEIGLAWSSHD- 478
+ Y V V G P ++ T P P + ++S + + + W +
Sbjct: 380 SPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEE 439
Query: 479 ----AESFQMHITQEG--AGNSRVEITTNQSII--IGGLFPGTKYCFEIVPKGPNGTEGA 530
++++ T + N+ + T+ ++ +G L PG Y ++ G
Sbjct: 440 PNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPP 499
Query: 531 SRTVCNRT---VPSAVFDIHVVYVTTTEMWLDWKSPDGASEYVYHLV--IESKHGSNHTS 585
S T+ +T VP+ D + T + L W P +Y LV H
Sbjct: 500 SPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERIIMYELVYWAAEDEDQQHKV 559
Query: 586 TYD--KAITLQGLIPGTLYNITISPEVDHVWG--DPN---STAQYTRPSNVSNI-DVSTN 637
T+D + TL+ L P TLY ++ D G P TAQ T + + VS
Sbjct: 560 TFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMG 619
Query: 638 TTAATLSW--QNFDDASPTYS-YCLLIEKAGNSSNATQVVTDIGITDATVTELIPGSSYT 694
+T +SW D + + Y + E VV I + + +L+ +T
Sbjct: 620 STTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGIS-REHSSWDLVGLEKWT 678
Query: 695 -----VEIFAQVGDGIKSLEPGRKSFCTDPASMASFDCEVVP-KEPALVLKWTCP----- 743
V VG G +S P D S EV P A+ + W P
Sbjct: 679 EYRVWVRAHTDVGPGPES-SPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQ 737
Query: 744 PGANAGFE---LEVSSGAWNNATHLESC-------SSENGTEYRTEVTYLNFSTSYNISI 793
G G++ + + +G ++ E +Y T ++ L T+Y++++
Sbjct: 738 HGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDYETTISGLTPETTYSVTV 797
Query: 794 ---TTVSCGKMAAPTRNTCTTGITDPPPPDGSPNITSVSHNSVKVKFSGFEASHGPIKAY 850
TT G + P T T + P + I++ + N+ +++ + G + Y
Sbjct: 798 AAYTTKGDGARSKPKIVTTTGAVPGRP----TMMISTTAMNTALLQWHPPKELPGELLGY 853
Query: 851 AVILTTGEAGHPSA-----DVLKYTYEDFKKGASDTYVTYLIRTEEKGRSQSLSEVLKYE 905
+ + P+ D +T KG TY+ R K R+ L E + E
Sbjct: 854 RLQYCRADEARPNTIDFGKDDQHFTVTGLHKG-----TTYIFRLAAKNRA-GLGEEFEKE 907
Query: 906 I 906
I
Sbjct: 908 I 908
Score = 45.1 bits (105), Expect = 5e-04
Identities = 56/263 (21%), Positives = 100/263 (38%), Gaps = 22/263 (8%)
Query: 323 QQSRDTEVLLVGLEPGTRYNATV--YSQAANGTEGQPQAIEFRTNAIQVFDVTAVNISAT 380
++S D E + GL P T Y+ TV Y+ +G +P+ + T A+ ++ +A
Sbjct: 775 EESEDYETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVT-TTGAVPGRPTMMISTTAM 833
Query: 381 SLTLI-WKVSDNESSSNYTYKIHVA----GETDSSNLNVSEPRAVIPGLRSSTFYNITVC 435
+ L+ W Y++ ++ + + + GL T Y +
Sbjct: 834 NTALLQWHPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLA 893
Query: 436 PVLGDIEGTPGFLQVHTPPVPVSDF----RVTVVSTTEIGLAWS-------SHDAESFQM 484
G ++ TP S F VT ++T+ LAW + S+ +
Sbjct: 894 AKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTV 953
Query: 485 HITQEGAGNSRVEITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTVP-SAV 543
+ ITT+ + GL P T Y ++ G+ S ++ +RT+P V
Sbjct: 954 VFRDINSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQV 1013
Query: 544 F--DIHVVYVTTTEMWLDWKSPD 564
F + V T + L W+ PD
Sbjct: 1014 FAKNFRVAAAMKTSVLLSWEVPD 1036
Score = 39.3 bits (90), Expect = 0.026
Identities = 33/131 (25%), Positives = 59/131 (45%), Gaps = 6/131 (4%)
Query: 327 DTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQVFDVTAVNISA---TSLT 383
DT L GL+P T Y+ V + + G+ +I+ RT ++ ++A TS+
Sbjct: 970 DTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMKTSVL 1029
Query: 384 LIWKVSDNESSSNYTYKIHVAGETDSSNLNVSEPRAVIPGLRSSTFYNITVCPVLGDIEG 443
L W+V D+ S+ +KI G+ S ++ R +I L+ +T Y+ + G
Sbjct: 1030 LSWEVPDSYKSA-VPFKILYNGQ--SVEVDGHSMRKLIADLQPNTEYSFVLMNRGSSAGG 1086
Query: 444 TPGFLQVHTPP 454
+ + T P
Sbjct: 1087 LQHLVSIRTAP 1097
Score = 35.8 bits (81), Expect = 0.28
Identities = 67/299 (22%), Positives = 100/299 (33%), Gaps = 33/299 (11%)
Query: 421 IPGLRSSTFYNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWSS-HDA 479
I GL T Y++TV +G ++ T V ++STT + A H
Sbjct: 784 ISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQWHPP 843
Query: 480 ESFQMHI---------TQEGAGNSRVEITTNQSIIIGGLFPGTKYCFEIVPKGPNGT--E 528
+ + E N+ +Q + GL GT Y F + K G E
Sbjct: 844 KELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEE 903
Query: 529 GASRTVCNRTVPSAV-FDIHVVYVTTTEMWLDWKSPDGASE----YVYHLVIESKHGSNH 583
+PS ++HV +TT+ L W P A Y +V +
Sbjct: 904 FEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQE 963
Query: 584 TS--TYDKAITLQGLIPGTLYNITISPEVDHVWGDPNSTAQYTRPSNVSNIDVSTNTTAA 641
T D TL GL P T Y+I + G P S + +R V + AA
Sbjct: 964 LQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSG-PLSPSIQSRTMPVEQVFAKNFRVAA 1022
Query: 642 T------LSWQNFDDASPTYSYCLLIEKAGNSSNATQVVTDIGITDATVTELIPGSSYT 694
LSW+ D + +L N V D + +L P + Y+
Sbjct: 1023 AMKTSVLLSWEVPDSYKSAVPFKILY-------NGQSVEVDGHSMRKLIADLQPNTEYS 1074
>gi|104487006 protein tyrosine phosphatase, receptor type, sigma
isoform 1 precursor [Homo sapiens]
Length = 1948
Score = 233 bits (594), Expect = 9e-61
Identities = 276/1122 (24%), Positives = 448/1122 (39%), Gaps = 199/1122 (17%)
Query: 328 TEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRT----NAIQVFDVTAVNISATSLT 383
T ++ L+P T Y + +++ G + RT + DV V++ +T++
Sbjct: 577 TSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAIL 636
Query: 384 LIWKVSDNESSSN----YTYKIHVAGETDSSNLNVS-----EPRAVIPGLRSSTFYNITV 434
+ W+ E+ + Y+ + G D V+ + ++ L T Y IT
Sbjct: 637 VSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITT 696
Query: 435 CP---VLGDIEGTPGFLQVH--TPPVPVSDFRVTVVSTTEIGLAWSSH-------DAESF 482
V E +P ++ P P ++ T I + W S +
Sbjct: 697 VAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGY 756
Query: 483 QMH-ITQEGA---GNSRV------------EITTNQSIIIGGLFPGTKYCFEIVP---KG 523
Q+H + EGA G R+ + T ++I L P T Y + KG
Sbjct: 757 QVHYVRMEGAEARGPPRIKDVMLADAQWETDDTAEYEMVITNLQPETAYSITVAAYTMKG 816
Query: 524 PNGTEGASRTVCNRTVPSAVFDIHVVYVTTTEMWLDWKSPDGASE---YVYHLVIESKHG 580
+G + V + + V + W+ P G +E Y L +
Sbjct: 817 -DGARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLARWEPPAGTAEDQVLGYRLQF-GRED 874
Query: 581 SNHTSTYD-----KAITLQGLIPGTLYNITISPEVDHVWGDPN----STAQYTRPSNVSN 631
S +T + T G+ G Y ++ G+ S + T +
Sbjct: 875 STPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEEAAEVLSIPEDTPRGHPQI 934
Query: 632 IDVSTNTTAAT--LSWQNFDDASPT---YSYCLLIEKAGNSSNATQV----VTDIGITDA 682
++ + N +A T L W A Y + + +AG A + + G +A
Sbjct: 935 LEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGALGPARETELPAAAEPGAENA 994
Query: 683 -TVTELIPGSSYTVEIFAQVGDGIKSLEPG--RKSFCTDPASMASFDCEVVPKEPALVLK 739
T+ L P ++Y +++ A G P ++F D S +F +++ K L L
Sbjct: 995 LTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRTFLRDQVSPKNFKVKMIMKTSVL-LS 1053
Query: 740 WTCPPGANAGFELEVSSGAWNNATHLESCSSENGTEYRTEVTYLNFSTSYNISITTVSCG 799
W P N+ ++ +N T +G + +T+L T YN +T + G
Sbjct: 1054 WEFPDNYNSPTPYKIQ---YNGLT-----LDVDGRTTKKLITHLKPHTFYNFVLT--NRG 1103
Query: 800 KMAAPTRNTCTTGITDPPPPDGSPNITSVSHNSVKVKFSGF-------EASHGPIKAYAV 852
+ T T T +G P++ K GF S P+++Y +
Sbjct: 1104 SSLGGLQQTVTAW-TAFNLLNGKPSVAP------KPDADGFIMVYLPDGQSPVPVQSYFI 1156
Query: 853 ILTTGEAGHPSADVLKYTYEDFKKGASDTYVTYLIRTEEKGRSQSLSEVLKYEIDVGNES 912
++ +K ++T L E+ L E+++ D+
Sbjct: 1157 VMVP-----------------LRKSRGGQFLTPLGSPED----MDLEELIQ---DISRLQ 1192
Query: 913 TTLGYYNGKLEPLGSYRACVAGFTNITFHP---------QNKGLIDGAESYVSF------ 957
++ +LE Y A TFHP N+GL G YV F
Sbjct: 1193 RRSLRHSRQLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPG-HRYVLFVLAVLQ 1251
Query: 958 --------SRYSDAVSL--PQDPGVICGA-----VFGCIFGALVIVTVGGFIFWRKKRKD 1002
S +SD L P ++ G V G + + I+ + I K + D
Sbjct: 1252 KSEPTFAASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPD 1311
Query: 1003 AKN-----------NEVSFSQIKPKKSKLIRVENFEA----------------------- 1028
+K N + PK +R NF+
Sbjct: 1312 SKRKDSEPRTKCLLNNADLAPHHPKDPVEMRRINFQTPDSGLRSPLREPGFHFESMLSHP 1371
Query: 1029 ---------YFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDI 1079
+ ++ +A+ + ++EYE + G + L N+ KNRY NV+ YD
Sbjct: 1372 PIPIADMAEHTERLKANDSLKLSQEYESID-PGQQFTWEHSNLEVNKPKNRYANVIAYDH 1430
Query: 1080 SRVKLS-VQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIML 1138
SRV L ++ DYINANY+ GY + +IATQGPLP T DFWRMVWE+ I+M+
Sbjct: 1431 SRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMM 1490
Query: 1139 TKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQF 1198
T+ E+ R KC++YWP++ + YG I V + I L + +R F++ +SE +RQF
Sbjct: 1491 TRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQF 1550
Query: 1199 HFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPES-PILVHCSAGVGRTGTFIAIDRLIY 1257
FT+WPDHGVP+ + F +R +PP++ PI+VHCSAGVGRTG FI ID ++
Sbjct: 1551 QFTAWPDHGVPEYPTPFLAF---LRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLE 1607
Query: 1258 QIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIV 1299
+I+ E TVDVYG V +R R MVQTEDQY F+++ +L+ V
Sbjct: 1608 RIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAV 1649
Score = 210 bits (534), Expect = 8e-54
Identities = 104/244 (42%), Positives = 152/244 (62%), Gaps = 1/244 (0%)
Query: 1059 AAELAENRGKNRYNNVLPYDISRVKLS-VQTHSTDDYINANYMPGYHSKKDFIATQGPLP 1117
+A L N+ KNR N++PY+ +RV L ++ DYINA+++ GY +K +IATQGPL
Sbjct: 1699 SANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLA 1758
Query: 1118 NTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEW 1177
T +DFWRM+WE N ++MLTK E GR KC +YWP++++ Y V +E +P++
Sbjct: 1759 ETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQY 1818
Query: 1178 TIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILV 1237
+R+F V + + +S +RQF FT WP+ GVP + + I+F V +Q + PI V
Sbjct: 1819 ILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISV 1878
Query: 1238 HCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLD 1297
HCSAGVGRTG FI + ++ ++ E VD++ V LR RP MVQTED+Y F Q L+
Sbjct: 1879 HCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALE 1938
Query: 1298 IVRS 1301
+ S
Sbjct: 1939 YLGS 1942
Score = 45.4 bits (106), Expect = 4e-04
Identities = 64/259 (24%), Positives = 103/259 (39%), Gaps = 24/259 (9%)
Query: 328 TEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTN----AIQVFDVTAVNISATSLT 383
T + GL P + Y V + + G +++ RT A +V A +SAT++
Sbjct: 385 TRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMI 444
Query: 384 LIWKVSDNESSSNYTYKI-------HVAGETDSSNLNVSEPRAVIPGLRSSTFYNITVCP 436
+ W+ + Y++ H G N++ S V L T Y + V
Sbjct: 445 VQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDET-YTVRVLA 503
Query: 437 VLGDIEGTPGF-LQVHTP---PVPVSDFRVTVVSTTEIGLAWSSHDAESFQMH--ITQEG 490
+G +QV T P + R S T I L+WS ES + + +EG
Sbjct: 504 FTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREG 563
Query: 491 AGNSRVEITTNQ--SIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTV---PSA-VF 544
V T + S ++ L P T+Y F + + P G + V RT+ PSA
Sbjct: 564 DHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQ 623
Query: 545 DIHVVYVTTTEMWLDWKSP 563
D+ V V +T + + W+ P
Sbjct: 624 DVKCVSVRSTAILVSWRPP 642
Score = 44.3 bits (103), Expect = 8e-04
Identities = 46/197 (23%), Positives = 77/197 (39%), Gaps = 39/197 (19%)
Query: 305 TAPVHDESLVGPVD----PSSGQQSRDTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAI 360
T V + +GP P++ + + + L GL+P T Y+ V + G +
Sbjct: 966 TVAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPV 1025
Query: 361 EFRT---NAIQVFDVTAVNISATSLTLIWKVSDNESSSNYTYKIHVAGETDSSNLNVSEP 417
+RT + + + I TS+ L W+ DN +S YKI G T +++
Sbjct: 1026 RYRTFLRDQVSPKNFKVKMIMKTSVLLSWEFPDNYNSPT-PYKIQYNGLT--LDVDGRTT 1082
Query: 418 RAVIPGLRSSTFYN----------------ITVCPVLGDIEGTP---------GFLQVHT 452
+ +I L+ TFYN +T + G P GF+ V+
Sbjct: 1083 KKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYL 1142
Query: 453 P----PVPVSDFRVTVV 465
P PVPV + + +V
Sbjct: 1143 PDGQSPVPVQSYFIVMV 1159
>gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1
precursor [Homo sapiens]
Length = 2315
Score = 233 bits (593), Expect = 1e-60
Identities = 170/566 (30%), Positives = 277/566 (48%), Gaps = 74/566 (13%)
Query: 784 NFSTSYNISITTVSCGKMAAPTRNTCTTGITDPPPPDGSPNITSVSHNSVKVKF-----S 838
N SY++S + ++ + + ++ TG+ P S N S HN K + S
Sbjct: 1470 NNPISYSLSENSEEDNRVTSVSSDS-QTGMDRSPGKSPSANGLSQKHNDGKEENDIQTGS 1528
Query: 839 GFEASHGPIKAYAVILTTGEAGHPSADVLKYTYEDFKKGASDTYVTYLIRTEEKGRSQSL 898
KA+AV+ + E+G T + + + T ++ T EK L
Sbjct: 1529 ALLPLSPESKAWAVLTSDEESGSGQG-----TSDSLNENETSTDFSFA-DTNEKDADGIL 1582
Query: 899 SEVLKYEIDVGNESTTLGYYNGKLEPLGSYRACVAGFTNI----TFHPQNKGLIDGAESY 954
+ G+ T G+ + S + V + + H GL +G ES
Sbjct: 1583 A--------AGDSEITPGFPQSPTSSVTSENSEVFHVSEAEASNSSHESRIGLAEGLES- 1633
Query: 955 VSFSRYSDAVSLPQDPGVICGAVFGCIFGALVIVTVGGFIFWRKKRKDAK---NNEVSFS 1011
+ VI + + ++V VG I+WRK + A + S
Sbjct: 1634 -------------EKKAVIPLVIVSALTFICLVVLVGILIYWRKCFQTAHFYLEDSTSPR 1680
Query: 1012 QIKPKKSKLIRVENFEA-----YFKKQQAD--SNCGFAEEYEDLK---------LVGISQ 1055
I + + + + +F K AD ++ GF EE+E LK V +
Sbjct: 1681 VISTPPTPIFPISDDVGAIPIKHFPKHVADLHASSGFTEEFETLKEFYQEVQSCTVDLGI 1740
Query: 1056 PKYAAELAENRGKNRYNNVLPYDISRVKLSVQTHSTD---DYINANYMPGYHSKKDFIAT 1112
++ +N+ KNRY N++ YD SRVKL+ DYINANY+ GY+ K +IA
Sbjct: 1741 TADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGKLTDYINANYVDGYNRPKAYIAA 1800
Query: 1113 QGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEI 1172
QGPL +T +DFWRM+WE NV I+M+T VE+GR KC++YWP+ +++YG+ V S
Sbjct: 1801 QGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQ 1860
Query: 1173 VLPEWTIRDFTVKNIQTSE--------SHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRD 1224
VL +T+R+FT++N + + + Q+H+T WPD GVP+ + ++ F VR
Sbjct: 1861 VLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTF---VRK 1917
Query: 1225 --YMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMV 1282
Y K+ P++VHCSAGVGRTGT+I +D ++ QI++E TV+++G + +R R +V
Sbjct: 1918 AAYAKRH-AVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLV 1976
Query: 1283 QTEDQYVFLNQCVLDIVRSQKDSKVD 1308
QTE+QYVF++ +++ + S++ +D
Sbjct: 1977 QTEEQYVFIHDTLVEAILSKETEVLD 2002
Score = 135 bits (341), Expect = 2e-31
Identities = 84/272 (30%), Positives = 146/272 (53%), Gaps = 18/272 (6%)
Query: 1043 EEYEDLKLVGISQPKYAAELAE-NRGKNRYNNVLPYDISRVKLSVQTHSTDDYINANYMP 1101
++++ L I Q Y+A L + NR KNR ++++P + SRV +S + DYINA+Y+
Sbjct: 2025 KQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSGEGTDYINASYIM 2084
Query: 1102 GYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEE---YWPSK-- 1156
GY+ +FI TQ PL +T+KDFWRM+W+ N ++M + G+ E+ YWP+K
Sbjct: 2085 GYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVM----IPDGQNMAEDEFVYWPNKDE 2140
Query: 1157 --QAQDYGDITVAMTSEIVLPE--WTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTT 1212
+ + +A + + E I+DF ++ Q +R F WP+ PD +
Sbjct: 2141 PINCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPN---PD-S 2196
Query: 1213 DLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVY 1272
+ F + + + + P++VH G GTF A+ L++Q+E EN+VDVY +
Sbjct: 2197 PISKTFELISVIKEEAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAK 2256
Query: 1273 DLRMHRPLMVQTEDQYVFLNQCVLDIVRSQKD 1304
+ + RP + +QY FL + +L +V ++++
Sbjct: 2257 MINLMRPGVFADIEQYQFLYKVILSLVSTRQE 2288
>gi|194097398 protein tyrosine phosphatase, receptor type, G precursor
[Homo sapiens]
Length = 1445
Score = 231 bits (590), Expect = 3e-60
Identities = 116/301 (38%), Positives = 187/301 (62%), Gaps = 18/301 (5%)
Query: 1015 PKKSKLIRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQPKYA--AELAENRGKNRYN 1072
P + I V+ F + + +++ GF+E++E+++ A + EN+ KNRY
Sbjct: 822 PDDMEAIPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTADMNITAEHSNHPENKHKNRYI 881
Query: 1073 NVLPYDISRVKLSV---QTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWE 1129
N+L YD SRVKL + DYINANY+ GY+ K +IATQGPL +T +DFWRM+WE
Sbjct: 882 NILAYDHSRVKLRPLPGKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWE 941
Query: 1130 KNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQT 1189
+N I+M+T VE+GR KC++YWP++ +++YG+I V + S + +T+R F+++N +
Sbjct: 942 QNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKV 1001
Query: 1190 SESHP-----------LRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILVH 1238
+ + Q+H+T WPD GVP+ ++ F + R + P P+LVH
Sbjct: 1002 KKGQKGNPKGRQNERVVIQYHYTQWPDMGVPEYALPVLTF--VRRSSAARMPETGPVLVH 1059
Query: 1239 CSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDI 1298
CSAGVGRTGT+I ID ++ QI++++TV+V G + +R R +VQTE+QY+F++ +L+
Sbjct: 1060 CSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEA 1119
Query: 1299 V 1299
+
Sbjct: 1120 I 1120
Score = 125 bits (314), Expect = 3e-28
Identities = 93/296 (31%), Positives = 145/296 (48%), Gaps = 26/296 (8%)
Query: 1046 EDLKLVGISQPKY----AAELAENRGKNRYNNVLPYDISRVKLS-VQTHSTDDYINANYM 1100
+ KLV KY +A+ N+ KNR ++V+P + +RV L+ + DYINA+Y+
Sbjct: 1152 KQFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYI 1211
Query: 1101 PGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCE-EYWPSK-QA 1158
GY+ +FI TQ PLP+T KDFWRM+W+ N I+ML Q + E YWPS+ ++
Sbjct: 1212 MGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPD--NQSLAEDEFVYWPSREES 1269
Query: 1159 QDYGDITVAMTSEIVL-----PEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVP-DTT 1212
+ TV + S+ L + I DF ++ Q +R F WP+ P +T
Sbjct: 1270 MNCEAFTVTLISKDRLCLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPISST 1329
Query: 1213 DLLINF---RYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYG 1269
LIN L RD P +VH G G A+ L Q+ENEN VDV+
Sbjct: 1330 FELINVIKEEALTRD--------GPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQ 1381
Query: 1270 IVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQKDSKVDLIYQNTTAMTIYENLAP 1325
+ + + RP + +QY F+ + +L +V ++++ + A+ I + P
Sbjct: 1382 VAKMINLMRPGVFTDIEQYQFIYKAMLSLVSTKENGNGPMTVDKNGAVLIADESDP 1437
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.131 0.389
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 54,742,405
Number of Sequences: 37866
Number of extensions: 2645034
Number of successful extensions: 7773
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 126
Number of HSP's successfully gapped in prelim test: 128
Number of HSP's that attempted gapping in prelim test: 5780
Number of HSP's gapped (non-prelim): 1311
length of query: 1337
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1223
effective length of database: 13,930,794
effective search space: 17037361062
effective search space used: 17037361062
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.