Guide to the Human Genome
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Search of human proteins with 148728162

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|148728162 protein tyrosine phosphatase, receptor type, J
isoform 1 precursor [Homo sapiens]
         (1337 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|148728162 protein tyrosine phosphatase, receptor type, J isof...  2712   0.0  
gi|148728160 protein tyrosine phosphatase, receptor type, J isof...  1079   0.0  
gi|157952215 protein tyrosine phosphatase, receptor type, B isof...   428   e-119
gi|157952213 protein tyrosine phosphatase, receptor type, B isof...   428   e-119
gi|241896924 protein tyrosine phosphatase, receptor type, H isof...   387   e-107
gi|241896926 protein tyrosine phosphatase, receptor type, H isof...   362   1e-99
gi|4506323 receptor-type protein tyrosine phosphatase O isoform ...   284   3e-76
gi|13677220 receptor-type protein tyrosine phosphatase O isoform...   279   1e-74
gi|13677216 receptor-type protein tyrosine phosphatase O isoform...   279   1e-74
gi|13677222 receptor-type protein tyrosine phosphatase O isoform...   278   3e-74
gi|13677218 receptor-type protein tyrosine phosphatase O isoform...   278   3e-74
gi|13677214 receptor-type protein tyrosine phosphatase O isoform...   278   3e-74
gi|18860894 protein tyrosine phosphatase, receptor type, D isofo...   274   5e-73
gi|104487002 protein tyrosine phosphatase, receptor type, D isof...   269   1e-71
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo...   269   1e-71
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor...   266   8e-71
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo...   266   8e-71
gi|104487611 protein tyrosine phosphatase, receptor type, sigma ...   258   3e-68
gi|104487295 protein tyrosine phosphatase, receptor type, sigma ...   258   3e-68
gi|222537743 protein tyrosine phosphatase, receptor type, Q [Hom...   256   8e-68
gi|148539860 protein tyrosine phosphatase, receptor type, T isof...   247   6e-65
gi|148539858 protein tyrosine phosphatase, receptor type, T isof...   247   6e-65
gi|157419150 protein tyrosine phosphatase, receptor type, M isof...   244   3e-64
gi|157419152 protein tyrosine phosphatase, receptor type, M isof...   244   3e-64
gi|104487297 protein tyrosine phosphatase, receptor type, sigma ...   243   7e-64
gi|109633039 protein tyrosine phosphatase, receptor type, F isof...   239   1e-62
gi|109633041 protein tyrosine phosphatase, receptor type, F isof...   238   2e-62
gi|104487006 protein tyrosine phosphatase, receptor type, sigma ...   233   9e-61
gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1 p...   233   1e-60
gi|194097398 protein tyrosine phosphatase, receptor type, G prec...   231   3e-60

>gi|148728162 protein tyrosine phosphatase, receptor type, J isoform 1
            precursor [Homo sapiens]
          Length = 1337

 Score = 2712 bits (7029), Expect = 0.0
 Identities = 1337/1337 (100%), Positives = 1337/1337 (100%)

Query: 1    MKPAAREARLPPRSPGLRWALPLLLLLLRLGQILCAGGTPSPIPDPSVATVATGENGITQ 60
            MKPAAREARLPPRSPGLRWALPLLLLLLRLGQILCAGGTPSPIPDPSVATVATGENGITQ
Sbjct: 1    MKPAAREARLPPRSPGLRWALPLLLLLLRLGQILCAGGTPSPIPDPSVATVATGENGITQ 60

Query: 61   ISSTAESFHKQNGTGTPQVETNTSEDGESSGANDSLRTPEQGSNGTDGASQKTPSSTGPS 120
            ISSTAESFHKQNGTGTPQVETNTSEDGESSGANDSLRTPEQGSNGTDGASQKTPSSTGPS
Sbjct: 61   ISSTAESFHKQNGTGTPQVETNTSEDGESSGANDSLRTPEQGSNGTDGASQKTPSSTGPS 120

Query: 121  PVFDIKAVSISPTNVILTWKSNDTAASEYKYVVKHKMENEKTITVVHQPWCNITGLRPAT 180
            PVFDIKAVSISPTNVILTWKSNDTAASEYKYVVKHKMENEKTITVVHQPWCNITGLRPAT
Sbjct: 121  PVFDIKAVSISPTNVILTWKSNDTAASEYKYVVKHKMENEKTITVVHQPWCNITGLRPAT 180

Query: 181  SYVFSITPGIGNETWGDPRVIKVITEPIPVSDLRVALTGVRKAALSWSNGNGTASCRVLL 240
            SYVFSITPGIGNETWGDPRVIKVITEPIPVSDLRVALTGVRKAALSWSNGNGTASCRVLL
Sbjct: 181  SYVFSITPGIGNETWGDPRVIKVITEPIPVSDLRVALTGVRKAALSWSNGNGTASCRVLL 240

Query: 241  ESIGSHEELTQDSRLQVNISGLKPGVQYNINPYLLQSNKTKGDPLGTEGGLDASNTERSR 300
            ESIGSHEELTQDSRLQVNISGLKPGVQYNINPYLLQSNKTKGDPLGTEGGLDASNTERSR
Sbjct: 241  ESIGSHEELTQDSRLQVNISGLKPGVQYNINPYLLQSNKTKGDPLGTEGGLDASNTERSR 300

Query: 301  AGSPTAPVHDESLVGPVDPSSGQQSRDTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAI 360
            AGSPTAPVHDESLVGPVDPSSGQQSRDTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAI
Sbjct: 301  AGSPTAPVHDESLVGPVDPSSGQQSRDTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAI 360

Query: 361  EFRTNAIQVFDVTAVNISATSLTLIWKVSDNESSSNYTYKIHVAGETDSSNLNVSEPRAV 420
            EFRTNAIQVFDVTAVNISATSLTLIWKVSDNESSSNYTYKIHVAGETDSSNLNVSEPRAV
Sbjct: 361  EFRTNAIQVFDVTAVNISATSLTLIWKVSDNESSSNYTYKIHVAGETDSSNLNVSEPRAV 420

Query: 421  IPGLRSSTFYNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDAE 480
            IPGLRSSTFYNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDAE
Sbjct: 421  IPGLRSSTFYNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDAE 480

Query: 481  SFQMHITQEGAGNSRVEITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTVP 540
            SFQMHITQEGAGNSRVEITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTVP
Sbjct: 481  SFQMHITQEGAGNSRVEITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTVP 540

Query: 541  SAVFDIHVVYVTTTEMWLDWKSPDGASEYVYHLVIESKHGSNHTSTYDKAITLQGLIPGT 600
            SAVFDIHVVYVTTTEMWLDWKSPDGASEYVYHLVIESKHGSNHTSTYDKAITLQGLIPGT
Sbjct: 541  SAVFDIHVVYVTTTEMWLDWKSPDGASEYVYHLVIESKHGSNHTSTYDKAITLQGLIPGT 600

Query: 601  LYNITISPEVDHVWGDPNSTAQYTRPSNVSNIDVSTNTTAATLSWQNFDDASPTYSYCLL 660
            LYNITISPEVDHVWGDPNSTAQYTRPSNVSNIDVSTNTTAATLSWQNFDDASPTYSYCLL
Sbjct: 601  LYNITISPEVDHVWGDPNSTAQYTRPSNVSNIDVSTNTTAATLSWQNFDDASPTYSYCLL 660

Query: 661  IEKAGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQVGDGIKSLEPGRKSFCTDPA 720
            IEKAGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQVGDGIKSLEPGRKSFCTDPA
Sbjct: 661  IEKAGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQVGDGIKSLEPGRKSFCTDPA 720

Query: 721  SMASFDCEVVPKEPALVLKWTCPPGANAGFELEVSSGAWNNATHLESCSSENGTEYRTEV 780
            SMASFDCEVVPKEPALVLKWTCPPGANAGFELEVSSGAWNNATHLESCSSENGTEYRTEV
Sbjct: 721  SMASFDCEVVPKEPALVLKWTCPPGANAGFELEVSSGAWNNATHLESCSSENGTEYRTEV 780

Query: 781  TYLNFSTSYNISITTVSCGKMAAPTRNTCTTGITDPPPPDGSPNITSVSHNSVKVKFSGF 840
            TYLNFSTSYNISITTVSCGKMAAPTRNTCTTGITDPPPPDGSPNITSVSHNSVKVKFSGF
Sbjct: 781  TYLNFSTSYNISITTVSCGKMAAPTRNTCTTGITDPPPPDGSPNITSVSHNSVKVKFSGF 840

Query: 841  EASHGPIKAYAVILTTGEAGHPSADVLKYTYEDFKKGASDTYVTYLIRTEEKGRSQSLSE 900
            EASHGPIKAYAVILTTGEAGHPSADVLKYTYEDFKKGASDTYVTYLIRTEEKGRSQSLSE
Sbjct: 841  EASHGPIKAYAVILTTGEAGHPSADVLKYTYEDFKKGASDTYVTYLIRTEEKGRSQSLSE 900

Query: 901  VLKYEIDVGNESTTLGYYNGKLEPLGSYRACVAGFTNITFHPQNKGLIDGAESYVSFSRY 960
            VLKYEIDVGNESTTLGYYNGKLEPLGSYRACVAGFTNITFHPQNKGLIDGAESYVSFSRY
Sbjct: 901  VLKYEIDVGNESTTLGYYNGKLEPLGSYRACVAGFTNITFHPQNKGLIDGAESYVSFSRY 960

Query: 961  SDAVSLPQDPGVICGAVFGCIFGALVIVTVGGFIFWRKKRKDAKNNEVSFSQIKPKKSKL 1020
            SDAVSLPQDPGVICGAVFGCIFGALVIVTVGGFIFWRKKRKDAKNNEVSFSQIKPKKSKL
Sbjct: 961  SDAVSLPQDPGVICGAVFGCIFGALVIVTVGGFIFWRKKRKDAKNNEVSFSQIKPKKSKL 1020

Query: 1021 IRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDIS 1080
            IRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDIS
Sbjct: 1021 IRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDIS 1080

Query: 1081 RVKLSVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTK 1140
            RVKLSVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTK
Sbjct: 1081 RVKLSVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTK 1140

Query: 1141 CVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHF 1200
            CVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHF
Sbjct: 1141 CVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHF 1200

Query: 1201 TSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIE 1260
            TSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIE
Sbjct: 1201 TSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIE 1260

Query: 1261 NENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQKDSKVDLIYQNTTAMTIY 1320
            NENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQKDSKVDLIYQNTTAMTIY
Sbjct: 1261 NENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQKDSKVDLIYQNTTAMTIY 1320

Query: 1321 ENLAPVTTFGKTNGYIA 1337
            ENLAPVTTFGKTNGYIA
Sbjct: 1321 ENLAPVTTFGKTNGYIA 1337


>gi|148728160 protein tyrosine phosphatase, receptor type, J isoform
           2 precursor [Homo sapiens]
          Length = 539

 Score = 1079 bits (2791), Expect = 0.0
 Identities = 538/538 (100%), Positives = 538/538 (100%)

Query: 1   MKPAAREARLPPRSPGLRWALPLLLLLLRLGQILCAGGTPSPIPDPSVATVATGENGITQ 60
           MKPAAREARLPPRSPGLRWALPLLLLLLRLGQILCAGGTPSPIPDPSVATVATGENGITQ
Sbjct: 1   MKPAAREARLPPRSPGLRWALPLLLLLLRLGQILCAGGTPSPIPDPSVATVATGENGITQ 60

Query: 61  ISSTAESFHKQNGTGTPQVETNTSEDGESSGANDSLRTPEQGSNGTDGASQKTPSSTGPS 120
           ISSTAESFHKQNGTGTPQVETNTSEDGESSGANDSLRTPEQGSNGTDGASQKTPSSTGPS
Sbjct: 61  ISSTAESFHKQNGTGTPQVETNTSEDGESSGANDSLRTPEQGSNGTDGASQKTPSSTGPS 120

Query: 121 PVFDIKAVSISPTNVILTWKSNDTAASEYKYVVKHKMENEKTITVVHQPWCNITGLRPAT 180
           PVFDIKAVSISPTNVILTWKSNDTAASEYKYVVKHKMENEKTITVVHQPWCNITGLRPAT
Sbjct: 121 PVFDIKAVSISPTNVILTWKSNDTAASEYKYVVKHKMENEKTITVVHQPWCNITGLRPAT 180

Query: 181 SYVFSITPGIGNETWGDPRVIKVITEPIPVSDLRVALTGVRKAALSWSNGNGTASCRVLL 240
           SYVFSITPGIGNETWGDPRVIKVITEPIPVSDLRVALTGVRKAALSWSNGNGTASCRVLL
Sbjct: 181 SYVFSITPGIGNETWGDPRVIKVITEPIPVSDLRVALTGVRKAALSWSNGNGTASCRVLL 240

Query: 241 ESIGSHEELTQDSRLQVNISGLKPGVQYNINPYLLQSNKTKGDPLGTEGGLDASNTERSR 300
           ESIGSHEELTQDSRLQVNISGLKPGVQYNINPYLLQSNKTKGDPLGTEGGLDASNTERSR
Sbjct: 241 ESIGSHEELTQDSRLQVNISGLKPGVQYNINPYLLQSNKTKGDPLGTEGGLDASNTERSR 300

Query: 301 AGSPTAPVHDESLVGPVDPSSGQQSRDTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAI 360
           AGSPTAPVHDESLVGPVDPSSGQQSRDTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAI
Sbjct: 301 AGSPTAPVHDESLVGPVDPSSGQQSRDTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAI 360

Query: 361 EFRTNAIQVFDVTAVNISATSLTLIWKVSDNESSSNYTYKIHVAGETDSSNLNVSEPRAV 420
           EFRTNAIQVFDVTAVNISATSLTLIWKVSDNESSSNYTYKIHVAGETDSSNLNVSEPRAV
Sbjct: 361 EFRTNAIQVFDVTAVNISATSLTLIWKVSDNESSSNYTYKIHVAGETDSSNLNVSEPRAV 420

Query: 421 IPGLRSSTFYNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDAE 480
           IPGLRSSTFYNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDAE
Sbjct: 421 IPGLRSSTFYNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDAE 480

Query: 481 SFQMHITQEGAGNSRVEITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRT 538
           SFQMHITQEGAGNSRVEITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRT
Sbjct: 481 SFQMHITQEGAGNSRVEITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRT 538



 Score =  108 bits (271), Expect = 3e-23
 Identities = 105/406 (25%), Positives = 165/406 (40%), Gaps = 64/406 (15%)

Query: 332 LVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQVFDVTAVNISATSLTLIWKVSDN 391
           + GL P T Y  ++     N T G P+ I+  T  I V D+           L W     
Sbjct: 173 ITGLRPATSYVFSITPGIGNETWGDPRVIKVITEPIPVSDLRVALTGVRKAALSW----- 227

Query: 392 ESSSNYTYKIHVAGETDSSNLNVSEPRAV---IPGLRSSTFYNITVCPVL-------GDI 441
            S+ N T    V  E+  S+  +++   +   I GL+    YNI   P L       GD 
Sbjct: 228 -SNGNGTASCRVLLESIGSHEELTQDSRLQVNISGLKPGVQYNIN--PYLLQSNKTKGDP 284

Query: 442 EGTPGFLQVH--------TPPVPVSDFRVTVVSTTEIGLAWSSHDAESFQMHITQEGAGN 493
            GT G L           +P  PV D   ++V   +      S D E             
Sbjct: 285 LGTEGGLDASNTERSRAGSPTAPVHD--ESLVGPVDPSSGQQSRDTE------------- 329

Query: 494 SRVEITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTVPSAVFDIHVVYVTT 553
                     +++ GL PGT+Y   +  +  NGTEG  + +  RT    VFD+  V ++ 
Sbjct: 330 ----------VLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQVFDVTAVNISA 379

Query: 554 TEMWLDWKSPD--GASEYVYHLVIESKHGSNHTSTYDKAITLQGLIPGTLYNITISPEVD 611
           T + L WK  D   +S Y Y + +  +  S++ +  +    + GL   T YNIT+ P + 
Sbjct: 380 TSLTLIWKVSDNESSSNYTYKIHVAGETDSSNLNVSEPRAVIPGLRSSTFYNITVCPVLG 439

Query: 612 HVWGDPNSTAQYTRPSNVSNIDVS-TNTTAATLSWQNFDDASPTYSYCLLIEKAGNSSNA 670
            + G P     +T P  VS+  V+  +TT   L+W + D      S+ + I + G  ++ 
Sbjct: 440 DIEGTPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHD----AESFQMHITQEGAGNSR 495

Query: 671 TQVVTDIGITDATVTELIPGSSYTVEIFAQVGDGIKSLEPGRKSFC 716
            ++ T+  I    +  L PG+ Y  EI   V  G    E   ++ C
Sbjct: 496 VEITTNQSI---IIGGLFPGTKYCFEI---VPKGPNGTEGASRTVC 535



 Score =  106 bits (265), Expect = 1e-22
 Identities = 81/245 (33%), Positives = 114/245 (46%), Gaps = 17/245 (6%)

Query: 454 PVPVSDFRVTVVSTTEIGLAWSSHDAESFQMHITQEGAGNSRVEITTNQSIIIGGLFPGT 513
           P P+ D  V  V+T E G+   S  AESF     Q G G  +VE  T++     G   G 
Sbjct: 40  PSPIPDPSVATVATGENGITQISSTAESFHK---QNGTGTPQVETNTSED----GESSGA 92

Query: 514 KYCFEIVPKGPNGTEGASRTVCNRTVPSAVFDIHVVYVTTTEMWLDWKSPD-GASEYVYH 572
                   +G NGT+GAS+   + T PS VFDI  V ++ T + L WKS D  ASEY Y 
Sbjct: 93  NDSLRTPEQGSNGTDGASQKTPSSTGPSPVFDIKAVSISPTNVILTWKSNDTAASEYKYV 152

Query: 573 LVIESKHGSNHTSTYDKAITLQGLIPGTLYNITISPEV-DHVWGDPNSTAQYTRPSNVSN 631
           +  + ++    T  +     + GL P T Y  +I+P + +  WGDP      T P  VS+
Sbjct: 153 VKHKMENEKTITVVHQPWCNITGLRPATSYVFSITPGIGNETWGDPRVIKVITEPIPVSD 212

Query: 632 IDVS-TNTTAATLSWQNFDDASPTYSYCLLIEKAGNSSNATQVVTDIGITDATVTELIPG 690
           + V+ T    A LSW N    + T S  +L+E  G+    TQ           ++ L PG
Sbjct: 213 LRVALTGVRKAALSWSN---GNGTASCRVLLESIGSHEELTQ----DSRLQVNISGLKPG 265

Query: 691 SSYTV 695
             Y +
Sbjct: 266 VQYNI 270



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 30/86 (34%), Positives = 40/86 (46%), Gaps = 7/86 (8%)

Query: 40  PSPIPDPSVATVATGENGITQISSTAESFHK---QNGTGTPQVETNTSED----GESSGA 92
           P P+ D  V  V+T E G+   S  AESF     Q G G  +VE  T++     G   G 
Sbjct: 454 PVPVSDFRVTVVSTTEIGLAWSSHDAESFQMHITQEGAGNSRVEITTNQSIIIGGLFPGT 513

Query: 93  NDSLRTPEQGSNGTDGASQKTPSSTG 118
                   +G NGT+GAS+   + TG
Sbjct: 514 KYCFEIVPKGPNGTEGASRTVCNRTG 539


>gi|157952215 protein tyrosine phosphatase, receptor type, B isoform a
            [Homo sapiens]
          Length = 2215

 Score =  428 bits (1101), Expect = e-119
 Identities = 371/1290 (28%), Positives = 579/1290 (44%), Gaps = 154/1290 (11%)

Query: 137  LTWKSNDTAASEYKYVVKHKMENEKTITVVH-QPWCNITGLRPATSYVFSITPGIGN--- 192
            ++W         Y+  +K+K    +T ++   +  C    L P   Y  ++T   G    
Sbjct: 968  VSWVHATGDFDHYEVTIKNKNNFIQTKSIPKSENECVFVQLVPGRLYSVTVTTKSGQYEA 1027

Query: 193  ETWGDPRVIKVITEPIPVSDLRVALTGVRKAALSWSNGNGTAS---CRVLLESIGSHEEL 249
               G+ R I     P PV DL +         ++WS  NG       ++L   +      
Sbjct: 1028 NEQGNGRTI-----PEPVKDLTLRNRSTEDLHVTWSGANGDVDQYEIQLLFNDMKVFPPF 1082

Query: 250  -TQDSRLQVNISGLKPGVQYNINPYLLQSN--------------KTKGDPLGTEGGLDAS 294
               ++  +   + L PG QY I    +  +                K   +   G  D+ 
Sbjct: 1083 HLVNTATEYRFTSLTPGRQYKILVLTISGDVQQSAFIEGFTVPSAVKNIHISPNGATDSL 1142

Query: 295  NTERSRAGSPTAPVHDESLVGPVDPSSGQQSRDT-----EVLLVGLEPGTRYNATVYSQA 349
                +  G       D   V     S    S+       E     LE G +Y   + S  
Sbjct: 1143 TVNWTPGGGDV----DSYTVSAFRHSQKVDSQTIPKHVFEHTFHRLEAGEQYQIMIAS-- 1196

Query: 350  ANGTEGQPQAIEFRTNAIQVFDVTAVNI-SATSLTLIWKVSDNESSSNYTYKIHVAGETD 408
             +G+      +  RT    V  V A N  S+ SL + W+ +   +     Y I +  E  
Sbjct: 1197 VSGSLKNQINVVGRTVPASVQGVIADNAYSSYSLIVSWQKAAGVAER---YDILLLTENG 1253

Query: 409  SSNLNVSEPRAV----IPGLRSSTFYNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTV 464
                N SEP          L     Y I +  V G +       +  T P  V+D R+T 
Sbjct: 1254 ILLRNTSEPATTKQHKFEDLTPGKKYKIQILTVSGGLFSKEAQTEGRTVPAAVTDLRITE 1313

Query: 465  VSTTEIGLAWSSHDAESFQMHI---TQEGAGNSRVEITTN-QSIIIGGLFPGTKYCFEIV 520
             ST  +   W++ + E    +I     +G    R ++    QS     L  G  Y   IV
Sbjct: 1314 NSTRHLSFRWTASEGELSWYNIFLYNPDGNLQERAQVDPLVQSFSFQNLLQGRMYKMVIV 1373

Query: 521  PKGPNGTEGASRTVCNRTVPSAVFDIHVVYVTTTE-MWLDWKSPDGASEYVYHLVIESKH 579
                +G       +  RTVP++V  +      TT+ +W +W    G  ++ Y L++ + +
Sbjct: 1374 TH--SGELSNESFIFGRTVPASVSHLRGSNRNTTDSLWFNWSPASGDFDF-YELILYNPN 1430

Query: 580  GSNHTSTYDKAIT---LQGLIPG---TLYNITISPEVDHVWGDPNSTAQYTRPSNVSNID 633
            G+   +  DK +T    QGL+PG    L+ +T S ++ +     + TA  + PS +S  D
Sbjct: 1431 GTKKENWKDKDLTEWRFQGLVPGRKYVLWVVTHSGDLSNKVTAESRTAP-SPPSLMSFAD 1489

Query: 634  VSTNTTAATLS----WQNFDDASPTY---SYCLLIEKAGNSSNATQVVTDIGITDATVTE 686
            ++  + A T      W +++D    +       +     N  +  ++V            
Sbjct: 1490 IANTSLAITWKGPPDWTDYNDFELQWLPRDALTVFNPYNNRKSEGRIVYG---------- 1539

Query: 687  LIPGSSYTVEIFAQVGDGIKSL-EPGRKSFCTDPASMASFDCEVVPKEPALVLKWTCPPG 745
            L PG SY   +    GD  K+  +P   S  T P  + +  C       A+   W  P  
Sbjct: 1540 LRPGRSYQFNVKTVSGDSWKTYSKPIFGSVRTKPDKIQNLHCRP-QNSTAIACSWIPPDS 1598

Query: 746  ANAGFELEVSSGAWNNATHLESCSSENGTEYRTEVTYLNFST-----SYNISITTVSCGK 800
               G+ +E           +++   E   +   E + LN         Y +SI   S G 
Sbjct: 1599 DFDGYSIECRK--------MDTQEVEFSRKLEKEKSLLNIMMLVPHKRYLVSIKVQSAGM 1650

Query: 801  MAAPTRNTCTTGITDPPPPDGSPNITS----VSHNSVK--VKFSGFEASHGPIKAYAVIL 854
             +    ++  T I  PPPP     +      +S +S+   V  S F  ++G +K + V++
Sbjct: 1651 TSEVVEDSTITMIDRPPPPPPHIRVNEKDVLISKSSINFTVNCSWFSDTNGAVKYFTVVV 1710

Query: 855  TTGEAG--------HPSADVLKYTYEDFKKGASDTYVTYLIRTEEKGRSQSLSEVLKYEI 906
               +          HP    L+Y +    +     Y  +  +  E   S S S    + I
Sbjct: 1711 READGSDELKPEQQHPLPSYLEYRHNASIRVYQTNY--FASKCAENPNSNSKS----FNI 1764

Query: 907  DVGNESTTLG---------YYNGKLEPLGSYRACVAGFTNITFHPQNKGLIDGAESYVSF 957
             +G E  +LG         + +G L+P  +YR  +  FT +     ++ L +  +   S 
Sbjct: 1765 KLGAEMESLGGKCDPTQQKFCDGPLKPHTAYRISIRAFTQLF----DEDLKEFTKPLYSD 1820

Query: 958  SRYSDAVSLPQDPGVICGAVFGCIFGALVI---VTVGGFIFWRKK---RKDAKNNEVSFS 1011
            + +S  ++   +P  + GA+ G   G  +I   V V   +  R+K    ++  +  +S  
Sbjct: 1821 TFFSLPITTESEP--LFGAIEGVSAGLFLIGMLVAVVALLICRQKVSHGRERPSARLSIR 1878

Query: 1012 QIKP-------------KKSKLIRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQPKY 1058
            + +P             K S  I++  FE +F K QADSN   ++EYE+LK VG +Q   
Sbjct: 1879 RDRPLSVHLNLGQKGNRKTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCD 1938

Query: 1059 AAELAENRGKNRYNNVLPYDISRVKLS-VQTHSTDDYINANYMPGYHSKKDFIATQGPLP 1117
             A L ENRGKNRYNN+LPYD +RVKLS V      DYINA+Y+PG + ++++I TQGPLP
Sbjct: 1939 IALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLP 1998

Query: 1118 NTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQ-AQDYGDITVAMTSEIVLPE 1176
             T  DFW+MVWE+NV+ I+M+T+CVE+GR KC+ YWP+ Q +  YGD+ + M SE VLPE
Sbjct: 1999 GTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPE 2058

Query: 1177 WTIRDFTVKNIQTSESHPL-RQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPI 1235
            WTIR+F +   +  ++H L R FH+T WPDHGVP+TT  LI F   VRDY+ +SP   P 
Sbjct: 2059 WTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPT 2118

Query: 1236 LVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCV 1295
            +VHCSAGVGRTGTFIA+DR++ Q++++++VD+YG V+DLR+HR  MVQTE QYV+L+QCV
Sbjct: 2119 VVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCV 2178

Query: 1296 LDIVRSQKDSKVDLIYQNTTAMTIYENLAP 1325
             D++R++K        Q      IYEN+ P
Sbjct: 2179 RDVLRARKLRS----EQENPLFPIYENVNP 2204



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 136/647 (21%), Positives = 247/647 (38%), Gaps = 109/647 (16%)

Query: 171 CNITGLRPATSYVFSITPGIGNETWGDPRVIKVITEPIPVSDLRVALTGVRKAALS--WS 228
           CN+  L+  T Y F I       +  + R + + T+P+P +   V+       +L   W+
Sbjct: 298 CNLQDLQAGTIYNFRII------SLDEERTVVLQTDPLPPARFGVSKEKTTSTSLHVWWT 351

Query: 229 NGNGTASCRVLLESIGSHEELTQDSRLQVNIS-------GLKPGVQYNINPYLLQSNK-- 279
             +G  +   + +    + +  Q  ++Q + S        L  G +YNI    +   K  
Sbjct: 352 PSSGKVTSYEV-QLFDENNQKIQGVQIQESTSWNEYTFFNLTAGSKYNIAITAVSGGKRS 410

Query: 280 --------------------TKGDPLGTEGGLDASNTERSRAGSPTAPVHDESLV---GP 316
                               TK + L       + N ER R       + D+ ++   G 
Sbjct: 411 FSVYTNGSTVPSPVKDIGISTKANSLLISWSHGSGNVERYRL-----MLMDKGILVHGGV 465

Query: 317 VDPSSGQQSRDTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQVFDVTAVN 376
           VD  +      T     GL PG  YN TV ++AA     + + +  RT  ++V ++   N
Sbjct: 466 VDKHA------TSYAFHGLTPGYLYNLTVMTEAAGLQNYRWKLV--RTAPMEVSNLKVTN 517

Query: 377 I-SATSLTLIWKVSDNESSSNYTYKIHVAGETDSSNLNVS------EPRAVIPGLRSSTF 429
             S TSL + W+                 G  DS N+ +S      E R + P +  + F
Sbjct: 518 DGSLTSLKVKWQ--------------RPPGNVDSYNITLSHKGTIKESRVLAPWITETHF 563

Query: 430 --------YNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTE-IGLAWS--SHD 478
                   Y +TV  V G++      +   T P  V++           + ++WS  + D
Sbjct: 564 KELVPGRLYQVTVSCVSGELSAQKMAVG-RTFPDKVANLEANNNGRMRSLVVSWSPPAGD 622

Query: 479 AESFQMHITQEGAGNSRVEITTNQSIII---GGLFPGTKYCFEIVPKGPNGTEGASRTVC 535
            E +++ +  +      + +   ++  +    GL PG +Y  E++ +  +G    S    
Sbjct: 623 WEQYRILLFNDSVVLLNITVGKEETQYVMDDTGLVPGRQYEVEVIVE--SGNLKNSERCQ 680

Query: 536 NRTVPSAVFDIHVVYVTTTEMWLDWKSPDGASE-YVYHLVIESKHGSNHTSTYD-KAITL 593
            RTVP AV  + V +   T + + W++P    E Y+  L        + + + D K  T 
Sbjct: 681 GRTVPLAVLQLRVKHANETSLSIMWQTPVAEWEKYIISLADRDLLLIHKSLSKDAKEFTF 740

Query: 594 QGLIPGTLYNITISPEVDHVWGDPNSTAQYTRPSNVSNIDVSTN--TTAATLSWQNFDDA 651
             L+PG  Y  T++  +     + +S    T P+ V+++ V+    T++   +W      
Sbjct: 741 TDLVPGRKYMATVT-SISGDLKNSSSVKGRTVPAQVTDLHVANQGMTSSLFTNWTQAQGD 799

Query: 652 SPTYSYCLLIEKAGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQVGDGIKSLE-- 709
              Y   L+ E     + +    T    +  +   L  GS Y+V +   V  GI S +  
Sbjct: 800 VEFYQVLLIHENVVIKNESISSET----SRYSFHSLKSGSLYSV-VVTTVSGGISSRQVV 854

Query: 710 -PGRKSFCTDPASMASFDCEVVPKEPALVLKWTCPPGANAGFELEVS 755
             GR    T P+S++        +   L + W   PG    +E+ +S
Sbjct: 855 VEGR----TVPSSVSGVTVNNSGRNDYLSVSWLLAPGDVDNYEVTLS 897



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 143/685 (20%), Positives = 262/685 (38%), Gaps = 81/685 (11%)

Query: 110  SQKTPSSTGPSPVFDIKAVSISPTNVILTWKSNDTAASEYKYVVKHKMENEKTITVVHQP 169
            S++    T P  V  ++    + T++ + W++    A   KY++      ++ + ++H+ 
Sbjct: 676  SERCQGRTVPLAVLQLRVKHANETSLSIMWQT--PVAEWEKYIISLA---DRDLLLIHKS 730

Query: 170  WCN------ITGLRPATSYVFSITPGIGNETWGDPRVIKVITEPIPVSDLRVALTGVRKA 223
                      T L P   Y+ ++T   G+    +   +K  T P  V+DL VA  G+  +
Sbjct: 731  LSKDAKEFTFTDLVPGRKYMATVTSISGDLK--NSSSVKGRTVPAQVTDLHVANQGMTSS 788

Query: 224  ALS-WSNGNGTASC-RVLL--ESIGSHEELTQDSRLQVNISGLKPGVQYNINPYLLQSNK 279
              + W+   G     +VLL  E++    E       + +   LK G  Y++    +    
Sbjct: 789  LFTNWTQAQGDVEFYQVLLIHENVVIKNESISSETSRYSFHSLKSGSLYSVVVTTVSGGI 848

Query: 280  TKGDPL-------GTEGGLDASNTERSRAGSPT---APVHDESLVGPVDPSSGQQSRDTE 329
            +    +        +  G+  +N+ R+   S +   AP       G VD      S D +
Sbjct: 849  SSRQVVVEGRTVPSSVSGVTVNNSGRNDYLSVSWLLAP-------GDVDNYEVTLSHDGK 901

Query: 330  VL-------------LVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQVFDVTAVN 376
            V+                L PG  Y  T+ +++     G+ +   F         V  V+
Sbjct: 902  VVQSLVIAKSVRECSFSSLTPGRLYTVTITTRS-----GKYENHSFSQERTVPDKVQGVS 956

Query: 377  ISATSLTLIWKVSDNESSSNYT-YKIHVAGETD---SSNLNVSEPRAVIPGLRSSTFYNI 432
            +S ++ +   +VS   ++ ++  Y++ +  + +   + ++  SE   V   L     Y++
Sbjct: 957  VSNSARSDYLRVSWVHATGDFDHYEVTIKNKNNFIQTKSIPKSENECVFVQLVPGRLYSV 1016

Query: 433  TVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDAESFQMHITQEGAG 492
            TV    G  E         T P PV D  +   ST ++ + WS  + +  Q  I Q    
Sbjct: 1017 TVTTKSGQYEANEQG-NGRTIPEPVKDLTLRNRSTEDLHVTWSGANGDVDQYEI-QLLFN 1074

Query: 493  NSRV-----EITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTVPSAVFDIH 547
            + +V      + T        L PG +Y  +I+    +G    S  +   TVPSAV +IH
Sbjct: 1075 DMKVFPPFHLVNTATEYRFTSLTPGRQY--KILVLTISGDVQQSAFIEGFTVPSAVKNIH 1132

Query: 548  V-VYVTTTEMWLDWKSPDGASEYVYHLVIESKHGSNHTSTYDKAI---TLQGLIPGTLYN 603
            +     T  + ++W +P G     Y +          + T  K +   T   L  G  Y 
Sbjct: 1133 ISPNGATDSLTVNW-TPGGGDVDSYTVSAFRHSQKVDSQTIPKHVFEHTFHRLEAGEQYQ 1191

Query: 604  ITISPEVDHVWGDPNSTAQYTRPSNVSNI--DVSTNTTAATLSWQNFDDASPTYSYCLLI 661
            I I+     +    N   + T P++V  +  D + ++ +  +SWQ     +  Y   LL 
Sbjct: 1192 IMIASVSGSLKNQINVVGR-TVPASVQGVIADNAYSSYSLIVSWQKAAGVAERYDILLLT 1250

Query: 662  EKAGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQVGDGIKSLEPGRKSFCTDPAS 721
            E      N ++  T          +L PG  Y ++I   V  G+ S E  +    T PA+
Sbjct: 1251 ENGILLRNTSEPAT---TKQHKFEDLTPGKKYKIQILT-VSGGLFSKE-AQTEGRTVPAA 1305

Query: 722  MASFDCEVVPKEPA-LVLKWTCPPG 745
            +   D  +       L  +WT   G
Sbjct: 1306 VT--DLRITENSTRHLSFRWTASEG 1328



 Score = 58.2 bits (139), Expect = 5e-08
 Identities = 120/579 (20%), Positives = 228/579 (39%), Gaps = 75/579 (12%)

Query: 332 LVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQV--FDVTAVNISATSLTLIWKVS 389
           L  L+ GT YN  + S        + + +  +T+ +    F V+    ++TSL + W  S
Sbjct: 300 LQDLQAGTIYNFRIISL------DEERTVVLQTDPLPPARFGVSKEKTTSTSLHVWWTPS 353

Query: 390 DNESSSNYTYKIHVAGETDSS--NLNVSEPRA----VIPGLRSSTFYNITVCPVLGDIEG 443
             + +S   Y++ +  E +     + + E  +        L + + YNI +  V G    
Sbjct: 354 SGKVTS---YEVQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGSKYNIAITAVSGGKRS 410

Query: 444 TPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWS--SHDAESFQMHITQEG-AGNSRVEITT 500
              +    T P PV D  ++  + + + ++WS  S + E +++ +  +G   +  V    
Sbjct: 411 FSVYTNGSTVPSPVKDIGISTKANSLL-ISWSHGSGNVERYRLMLMDKGILVHGGVVDKH 469

Query: 501 NQSIIIGGLFPGTKYCFEIVPKGPNGTEGAS----RTVCNRTVPSAVFDIHVVY-VTTTE 555
             S    GL PG  Y   ++      TE A     R    RT P  V ++ V    + T 
Sbjct: 470 ATSYAFHGLTPGYLYNLTVM------TEAAGLQNYRWKLVRTAPMEVSNLKVTNDGSLTS 523

Query: 556 MWLDWKSPDGASEYVYHLVIESKHGSNHTSTYDKAIT---LQGLIPGTLYNITISPEVDH 612
           + + W+ P G  +  Y++ +  K     +      IT    + L+PG LY +T+S     
Sbjct: 524 LKVKWQRPPGNVD-SYNITLSHKGTIKESRVLAPWITETHFKELVPGRLYQVTVSCVSGE 582

Query: 613 VWGDPNSTAQYTRPSNVSNIDVSTNTTAATL---------SWQNFDDASPTYSYCLLIEK 663
           +     +  + T P  V+N++ + N    +L          W+ +       S  LL   
Sbjct: 583 LSAQKMAVGR-TFPDKVANLEANNNGRMRSLVVSWSPPAGDWEQYRILLFNDSVVLLNIT 641

Query: 664 AGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQVGDGIKSLEPGRKSFCTDPASMA 723
            G     TQ V D        T L+PG  Y VE+  + G+ +K+ E  R    T P ++ 
Sbjct: 642 VGKEE--TQYVMD-------DTGLVPGRQYEVEVIVESGN-LKNSE--RCQGRTVPLAVL 689

Query: 724 SFDCEVVPKEPALVLKWTCPPGANAGFELEVSSGAWNNATHLESCSSENGTEYRTEVTYL 783
               +    E +L + W  P    A +E  + S A  +   +    S++  E+    T L
Sbjct: 690 QLRVKHA-NETSLSIMWQTPV---AEWEKYIISLADRDLLLIHKSLSKDAKEF--TFTDL 743

Query: 784 NFSTSYNISITTVSCGKMAAPTRNTCTTGITDPPPPDGSPNITSVSHNSVKVKFSGFEAS 843
                Y  ++T++S        +N  ++ +     P    ++   +       F+ +  +
Sbjct: 744 VPGRKYMATVTSIS-----GDLKN--SSSVKGRTVPAQVTDLHVANQGMTSSLFTNWTQA 796

Query: 844 HGPIKAYAVIL----TTGEAGHPSADVLKYTYEDFKKGA 878
            G ++ Y V+L       +    S++  +Y++   K G+
Sbjct: 797 QGDVEFYQVLLIHENVVIKNESISSETSRYSFHSLKSGS 835



 Score = 37.4 bits (85), Expect = 0.097
 Identities = 79/348 (22%), Positives = 141/348 (40%), Gaps = 51/348 (14%)

Query: 115  SSTGPSPVFDIKAVSISPTNVILTWKSNDTAASEYKYVVKHKMENEKTITVVHQPWCN-- 172
            S T PSP   +    I+ T++ +TWK          + ++    +  T   V  P+ N  
Sbjct: 1475 SRTAPSPPSLMSFADIANTSLAITWKGPPDWTDYNDFELQWLPRDALT---VFNPYNNRK 1531

Query: 173  -----ITGLRPATSYVFSITPGIGN--ETWGDPRVIKVITEPIPVSDLRVALTGVRKAAL 225
                 + GLRP  SY F++    G+  +T+  P    V T+P  + +L          A 
Sbjct: 1532 SEGRIVYGLRPGRSYQFNVKTVSGDSWKTYSKPIFGSVRTKPDKIQNLHCRPQNSTAIAC 1591

Query: 226  SW----SNGNG-TASCRVL-LESIGSHEELTQDSRLQVNISGLKPGVQYNINPYLLQSNK 279
            SW    S+ +G +  CR +  + +    +L ++  L +NI  L P  +Y      L S K
Sbjct: 1592 SWIPPDSDFDGYSIECRKMDTQEVEFSRKLEKEKSL-LNIMMLVPHKRY------LVSIK 1644

Query: 280  TKGDPLGTEGGLDASNTERSRAGSPTAPVHDESLVGPVDPSSGQQSRDTEV---LLVGLE 336
             +   + +E   D++ T   R   P  P H    V   D    + S +  V         
Sbjct: 1645 VQSAGMTSEVVEDSTITMIDR--PPPPPPHIR--VNEKDVLISKSSINFTVNCSWFSDTN 1700

Query: 337  PGTRYNATVYSQAANGTEGQPQA-------IEFRTNA-IQVFDVTAVNISATSLTLIWKV 388
               +Y   V  +A    E +P+        +E+R NA I+V+     N  A+      K 
Sbjct: 1701 GAVKYFTVVVREADGSDELKPEQQHPLPSYLEYRHNASIRVYQ---TNYFAS------KC 1751

Query: 389  SDNESSSNYTYKIHVAGETDS--SNLNVSEPRAVIPGLRSSTFYNITV 434
            ++N +S++ ++ I +  E +S     + ++ +     L+  T Y I++
Sbjct: 1752 AENPNSNSKSFNIKLGAEMESLGGKCDPTQQKFCDGPLKPHTAYRISI 1799


>gi|157952213 protein tyrosine phosphatase, receptor type, B isoform b
            precursor [Homo sapiens]
          Length = 1997

 Score =  428 bits (1101), Expect = e-119
 Identities = 371/1290 (28%), Positives = 579/1290 (44%), Gaps = 154/1290 (11%)

Query: 137  LTWKSNDTAASEYKYVVKHKMENEKTITVVH-QPWCNITGLRPATSYVFSITPGIGN--- 192
            ++W         Y+  +K+K    +T ++   +  C    L P   Y  ++T   G    
Sbjct: 750  VSWVHATGDFDHYEVTIKNKNNFIQTKSIPKSENECVFVQLVPGRLYSVTVTTKSGQYEA 809

Query: 193  ETWGDPRVIKVITEPIPVSDLRVALTGVRKAALSWSNGNGTAS---CRVLLESIGSHEEL 249
               G+ R I     P PV DL +         ++WS  NG       ++L   +      
Sbjct: 810  NEQGNGRTI-----PEPVKDLTLRNRSTEDLHVTWSGANGDVDQYEIQLLFNDMKVFPPF 864

Query: 250  -TQDSRLQVNISGLKPGVQYNINPYLLQSN--------------KTKGDPLGTEGGLDAS 294
               ++  +   + L PG QY I    +  +                K   +   G  D+ 
Sbjct: 865  HLVNTATEYRFTSLTPGRQYKILVLTISGDVQQSAFIEGFTVPSAVKNIHISPNGATDSL 924

Query: 295  NTERSRAGSPTAPVHDESLVGPVDPSSGQQSRDT-----EVLLVGLEPGTRYNATVYSQA 349
                +  G       D   V     S    S+       E     LE G +Y   + S  
Sbjct: 925  TVNWTPGGGDV----DSYTVSAFRHSQKVDSQTIPKHVFEHTFHRLEAGEQYQIMIAS-- 978

Query: 350  ANGTEGQPQAIEFRTNAIQVFDVTAVNI-SATSLTLIWKVSDNESSSNYTYKIHVAGETD 408
             +G+      +  RT    V  V A N  S+ SL + W+ +   +     Y I +  E  
Sbjct: 979  VSGSLKNQINVVGRTVPASVQGVIADNAYSSYSLIVSWQKAAGVAER---YDILLLTENG 1035

Query: 409  SSNLNVSEPRAV----IPGLRSSTFYNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTV 464
                N SEP          L     Y I +  V G +       +  T P  V+D R+T 
Sbjct: 1036 ILLRNTSEPATTKQHKFEDLTPGKKYKIQILTVSGGLFSKEAQTEGRTVPAAVTDLRITE 1095

Query: 465  VSTTEIGLAWSSHDAESFQMHI---TQEGAGNSRVEITTN-QSIIIGGLFPGTKYCFEIV 520
             ST  +   W++ + E    +I     +G    R ++    QS     L  G  Y   IV
Sbjct: 1096 NSTRHLSFRWTASEGELSWYNIFLYNPDGNLQERAQVDPLVQSFSFQNLLQGRMYKMVIV 1155

Query: 521  PKGPNGTEGASRTVCNRTVPSAVFDIHVVYVTTTE-MWLDWKSPDGASEYVYHLVIESKH 579
                +G       +  RTVP++V  +      TT+ +W +W    G  ++ Y L++ + +
Sbjct: 1156 TH--SGELSNESFIFGRTVPASVSHLRGSNRNTTDSLWFNWSPASGDFDF-YELILYNPN 1212

Query: 580  GSNHTSTYDKAIT---LQGLIPG---TLYNITISPEVDHVWGDPNSTAQYTRPSNVSNID 633
            G+   +  DK +T    QGL+PG    L+ +T S ++ +     + TA  + PS +S  D
Sbjct: 1213 GTKKENWKDKDLTEWRFQGLVPGRKYVLWVVTHSGDLSNKVTAESRTAP-SPPSLMSFAD 1271

Query: 634  VSTNTTAATLS----WQNFDDASPTY---SYCLLIEKAGNSSNATQVVTDIGITDATVTE 686
            ++  + A T      W +++D    +       +     N  +  ++V            
Sbjct: 1272 IANTSLAITWKGPPDWTDYNDFELQWLPRDALTVFNPYNNRKSEGRIVYG---------- 1321

Query: 687  LIPGSSYTVEIFAQVGDGIKSL-EPGRKSFCTDPASMASFDCEVVPKEPALVLKWTCPPG 745
            L PG SY   +    GD  K+  +P   S  T P  + +  C       A+   W  P  
Sbjct: 1322 LRPGRSYQFNVKTVSGDSWKTYSKPIFGSVRTKPDKIQNLHCRP-QNSTAIACSWIPPDS 1380

Query: 746  ANAGFELEVSSGAWNNATHLESCSSENGTEYRTEVTYLNFST-----SYNISITTVSCGK 800
               G+ +E           +++   E   +   E + LN         Y +SI   S G 
Sbjct: 1381 DFDGYSIECRK--------MDTQEVEFSRKLEKEKSLLNIMMLVPHKRYLVSIKVQSAGM 1432

Query: 801  MAAPTRNTCTTGITDPPPPDGSPNITS----VSHNSVK--VKFSGFEASHGPIKAYAVIL 854
             +    ++  T I  PPPP     +      +S +S+   V  S F  ++G +K + V++
Sbjct: 1433 TSEVVEDSTITMIDRPPPPPPHIRVNEKDVLISKSSINFTVNCSWFSDTNGAVKYFTVVV 1492

Query: 855  TTGEAG--------HPSADVLKYTYEDFKKGASDTYVTYLIRTEEKGRSQSLSEVLKYEI 906
               +          HP    L+Y +    +     Y  +  +  E   S S S    + I
Sbjct: 1493 READGSDELKPEQQHPLPSYLEYRHNASIRVYQTNY--FASKCAENPNSNSKS----FNI 1546

Query: 907  DVGNESTTLG---------YYNGKLEPLGSYRACVAGFTNITFHPQNKGLIDGAESYVSF 957
             +G E  +LG         + +G L+P  +YR  +  FT +     ++ L +  +   S 
Sbjct: 1547 KLGAEMESLGGKCDPTQQKFCDGPLKPHTAYRISIRAFTQLF----DEDLKEFTKPLYSD 1602

Query: 958  SRYSDAVSLPQDPGVICGAVFGCIFGALVI---VTVGGFIFWRKK---RKDAKNNEVSFS 1011
            + +S  ++   +P  + GA+ G   G  +I   V V   +  R+K    ++  +  +S  
Sbjct: 1603 TFFSLPITTESEP--LFGAIEGVSAGLFLIGMLVAVVALLICRQKVSHGRERPSARLSIR 1660

Query: 1012 QIKP-------------KKSKLIRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQPKY 1058
            + +P             K S  I++  FE +F K QADSN   ++EYE+LK VG +Q   
Sbjct: 1661 RDRPLSVHLNLGQKGNRKTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCD 1720

Query: 1059 AAELAENRGKNRYNNVLPYDISRVKLS-VQTHSTDDYINANYMPGYHSKKDFIATQGPLP 1117
             A L ENRGKNRYNN+LPYD +RVKLS V      DYINA+Y+PG + ++++I TQGPLP
Sbjct: 1721 IALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLP 1780

Query: 1118 NTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQ-AQDYGDITVAMTSEIVLPE 1176
             T  DFW+MVWE+NV+ I+M+T+CVE+GR KC+ YWP+ Q +  YGD+ + M SE VLPE
Sbjct: 1781 GTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPE 1840

Query: 1177 WTIRDFTVKNIQTSESHPL-RQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPI 1235
            WTIR+F +   +  ++H L R FH+T WPDHGVP+TT  LI F   VRDY+ +SP   P 
Sbjct: 1841 WTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPT 1900

Query: 1236 LVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCV 1295
            +VHCSAGVGRTGTFIA+DR++ Q++++++VD+YG V+DLR+HR  MVQTE QYV+L+QCV
Sbjct: 1901 VVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCV 1960

Query: 1296 LDIVRSQKDSKVDLIYQNTTAMTIYENLAP 1325
             D++R++K        Q      IYEN+ P
Sbjct: 1961 RDVLRARKLRS----EQENPLFPIYENVNP 1986



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 136/647 (21%), Positives = 247/647 (38%), Gaps = 109/647 (16%)

Query: 171 CNITGLRPATSYVFSITPGIGNETWGDPRVIKVITEPIPVSDLRVALTGVRKAALS--WS 228
           CN+  L+  T Y F I       +  + R + + T+P+P +   V+       +L   W+
Sbjct: 80  CNLQDLQAGTIYNFRII------SLDEERTVVLQTDPLPPARFGVSKEKTTSTSLHVWWT 133

Query: 229 NGNGTASCRVLLESIGSHEELTQDSRLQVNIS-------GLKPGVQYNINPYLLQSNK-- 279
             +G  +   + +    + +  Q  ++Q + S        L  G +YNI    +   K  
Sbjct: 134 PSSGKVTSYEV-QLFDENNQKIQGVQIQESTSWNEYTFFNLTAGSKYNIAITAVSGGKRS 192

Query: 280 --------------------TKGDPLGTEGGLDASNTERSRAGSPTAPVHDESLV---GP 316
                               TK + L       + N ER R       + D+ ++   G 
Sbjct: 193 FSVYTNGSTVPSPVKDIGISTKANSLLISWSHGSGNVERYRL-----MLMDKGILVHGGV 247

Query: 317 VDPSSGQQSRDTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQVFDVTAVN 376
           VD  +      T     GL PG  YN TV ++AA     + + +  RT  ++V ++   N
Sbjct: 248 VDKHA------TSYAFHGLTPGYLYNLTVMTEAAGLQNYRWKLV--RTAPMEVSNLKVTN 299

Query: 377 I-SATSLTLIWKVSDNESSSNYTYKIHVAGETDSSNLNVS------EPRAVIPGLRSSTF 429
             S TSL + W+                 G  DS N+ +S      E R + P +  + F
Sbjct: 300 DGSLTSLKVKWQ--------------RPPGNVDSYNITLSHKGTIKESRVLAPWITETHF 345

Query: 430 --------YNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTE-IGLAWS--SHD 478
                   Y +TV  V G++      +   T P  V++           + ++WS  + D
Sbjct: 346 KELVPGRLYQVTVSCVSGELSAQKMAVG-RTFPDKVANLEANNNGRMRSLVVSWSPPAGD 404

Query: 479 AESFQMHITQEGAGNSRVEITTNQSIII---GGLFPGTKYCFEIVPKGPNGTEGASRTVC 535
            E +++ +  +      + +   ++  +    GL PG +Y  E++ +  +G    S    
Sbjct: 405 WEQYRILLFNDSVVLLNITVGKEETQYVMDDTGLVPGRQYEVEVIVE--SGNLKNSERCQ 462

Query: 536 NRTVPSAVFDIHVVYVTTTEMWLDWKSPDGASE-YVYHLVIESKHGSNHTSTYD-KAITL 593
            RTVP AV  + V +   T + + W++P    E Y+  L        + + + D K  T 
Sbjct: 463 GRTVPLAVLQLRVKHANETSLSIMWQTPVAEWEKYIISLADRDLLLIHKSLSKDAKEFTF 522

Query: 594 QGLIPGTLYNITISPEVDHVWGDPNSTAQYTRPSNVSNIDVSTN--TTAATLSWQNFDDA 651
             L+PG  Y  T++  +     + +S    T P+ V+++ V+    T++   +W      
Sbjct: 523 TDLVPGRKYMATVT-SISGDLKNSSSVKGRTVPAQVTDLHVANQGMTSSLFTNWTQAQGD 581

Query: 652 SPTYSYCLLIEKAGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQVGDGIKSLE-- 709
              Y   L+ E     + +    T    +  +   L  GS Y+V +   V  GI S +  
Sbjct: 582 VEFYQVLLIHENVVIKNESISSET----SRYSFHSLKSGSLYSV-VVTTVSGGISSRQVV 636

Query: 710 -PGRKSFCTDPASMASFDCEVVPKEPALVLKWTCPPGANAGFELEVS 755
             GR    T P+S++        +   L + W   PG    +E+ +S
Sbjct: 637 VEGR----TVPSSVSGVTVNNSGRNDYLSVSWLLAPGDVDNYEVTLS 679



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 143/685 (20%), Positives = 262/685 (38%), Gaps = 81/685 (11%)

Query: 110  SQKTPSSTGPSPVFDIKAVSISPTNVILTWKSNDTAASEYKYVVKHKMENEKTITVVHQP 169
            S++    T P  V  ++    + T++ + W++    A   KY++      ++ + ++H+ 
Sbjct: 458  SERCQGRTVPLAVLQLRVKHANETSLSIMWQT--PVAEWEKYIISLA---DRDLLLIHKS 512

Query: 170  WCN------ITGLRPATSYVFSITPGIGNETWGDPRVIKVITEPIPVSDLRVALTGVRKA 223
                      T L P   Y+ ++T   G+    +   +K  T P  V+DL VA  G+  +
Sbjct: 513  LSKDAKEFTFTDLVPGRKYMATVTSISGDLK--NSSSVKGRTVPAQVTDLHVANQGMTSS 570

Query: 224  ALS-WSNGNGTASC-RVLL--ESIGSHEELTQDSRLQVNISGLKPGVQYNINPYLLQSNK 279
              + W+   G     +VLL  E++    E       + +   LK G  Y++    +    
Sbjct: 571  LFTNWTQAQGDVEFYQVLLIHENVVIKNESISSETSRYSFHSLKSGSLYSVVVTTVSGGI 630

Query: 280  TKGDPL-------GTEGGLDASNTERSRAGSPT---APVHDESLVGPVDPSSGQQSRDTE 329
            +    +        +  G+  +N+ R+   S +   AP       G VD      S D +
Sbjct: 631  SSRQVVVEGRTVPSSVSGVTVNNSGRNDYLSVSWLLAP-------GDVDNYEVTLSHDGK 683

Query: 330  VL-------------LVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQVFDVTAVN 376
            V+                L PG  Y  T+ +++     G+ +   F         V  V+
Sbjct: 684  VVQSLVIAKSVRECSFSSLTPGRLYTVTITTRS-----GKYENHSFSQERTVPDKVQGVS 738

Query: 377  ISATSLTLIWKVSDNESSSNYT-YKIHVAGETD---SSNLNVSEPRAVIPGLRSSTFYNI 432
            +S ++ +   +VS   ++ ++  Y++ +  + +   + ++  SE   V   L     Y++
Sbjct: 739  VSNSARSDYLRVSWVHATGDFDHYEVTIKNKNNFIQTKSIPKSENECVFVQLVPGRLYSV 798

Query: 433  TVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDAESFQMHITQEGAG 492
            TV    G  E         T P PV D  +   ST ++ + WS  + +  Q  I Q    
Sbjct: 799  TVTTKSGQYEANEQG-NGRTIPEPVKDLTLRNRSTEDLHVTWSGANGDVDQYEI-QLLFN 856

Query: 493  NSRV-----EITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTVPSAVFDIH 547
            + +V      + T        L PG +Y  +I+    +G    S  +   TVPSAV +IH
Sbjct: 857  DMKVFPPFHLVNTATEYRFTSLTPGRQY--KILVLTISGDVQQSAFIEGFTVPSAVKNIH 914

Query: 548  V-VYVTTTEMWLDWKSPDGASEYVYHLVIESKHGSNHTSTYDKAI---TLQGLIPGTLYN 603
            +     T  + ++W +P G     Y +          + T  K +   T   L  G  Y 
Sbjct: 915  ISPNGATDSLTVNW-TPGGGDVDSYTVSAFRHSQKVDSQTIPKHVFEHTFHRLEAGEQYQ 973

Query: 604  ITISPEVDHVWGDPNSTAQYTRPSNVSNI--DVSTNTTAATLSWQNFDDASPTYSYCLLI 661
            I I+     +    N   + T P++V  +  D + ++ +  +SWQ     +  Y   LL 
Sbjct: 974  IMIASVSGSLKNQINVVGR-TVPASVQGVIADNAYSSYSLIVSWQKAAGVAERYDILLLT 1032

Query: 662  EKAGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQVGDGIKSLEPGRKSFCTDPAS 721
            E      N ++  T          +L PG  Y ++I   V  G+ S E  +    T PA+
Sbjct: 1033 ENGILLRNTSEPAT---TKQHKFEDLTPGKKYKIQILT-VSGGLFSKE-AQTEGRTVPAA 1087

Query: 722  MASFDCEVVPKEPA-LVLKWTCPPG 745
            +   D  +       L  +WT   G
Sbjct: 1088 VT--DLRITENSTRHLSFRWTASEG 1110



 Score = 58.2 bits (139), Expect = 5e-08
 Identities = 120/579 (20%), Positives = 228/579 (39%), Gaps = 75/579 (12%)

Query: 332 LVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQV--FDVTAVNISATSLTLIWKVS 389
           L  L+ GT YN  + S        + + +  +T+ +    F V+    ++TSL + W  S
Sbjct: 82  LQDLQAGTIYNFRIISL------DEERTVVLQTDPLPPARFGVSKEKTTSTSLHVWWTPS 135

Query: 390 DNESSSNYTYKIHVAGETDSS--NLNVSEPRA----VIPGLRSSTFYNITVCPVLGDIEG 443
             + +S   Y++ +  E +     + + E  +        L + + YNI +  V G    
Sbjct: 136 SGKVTS---YEVQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGSKYNIAITAVSGGKRS 192

Query: 444 TPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWS--SHDAESFQMHITQEG-AGNSRVEITT 500
              +    T P PV D  ++  + + + ++WS  S + E +++ +  +G   +  V    
Sbjct: 193 FSVYTNGSTVPSPVKDIGISTKANSLL-ISWSHGSGNVERYRLMLMDKGILVHGGVVDKH 251

Query: 501 NQSIIIGGLFPGTKYCFEIVPKGPNGTEGAS----RTVCNRTVPSAVFDIHVVY-VTTTE 555
             S    GL PG  Y   ++      TE A     R    RT P  V ++ V    + T 
Sbjct: 252 ATSYAFHGLTPGYLYNLTVM------TEAAGLQNYRWKLVRTAPMEVSNLKVTNDGSLTS 305

Query: 556 MWLDWKSPDGASEYVYHLVIESKHGSNHTSTYDKAIT---LQGLIPGTLYNITISPEVDH 612
           + + W+ P G  +  Y++ +  K     +      IT    + L+PG LY +T+S     
Sbjct: 306 LKVKWQRPPGNVD-SYNITLSHKGTIKESRVLAPWITETHFKELVPGRLYQVTVSCVSGE 364

Query: 613 VWGDPNSTAQYTRPSNVSNIDVSTNTTAATL---------SWQNFDDASPTYSYCLLIEK 663
           +     +  + T P  V+N++ + N    +L          W+ +       S  LL   
Sbjct: 365 LSAQKMAVGR-TFPDKVANLEANNNGRMRSLVVSWSPPAGDWEQYRILLFNDSVVLLNIT 423

Query: 664 AGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQVGDGIKSLEPGRKSFCTDPASMA 723
            G     TQ V D        T L+PG  Y VE+  + G+ +K+ E  R    T P ++ 
Sbjct: 424 VGKEE--TQYVMD-------DTGLVPGRQYEVEVIVESGN-LKNSE--RCQGRTVPLAVL 471

Query: 724 SFDCEVVPKEPALVLKWTCPPGANAGFELEVSSGAWNNATHLESCSSENGTEYRTEVTYL 783
               +    E +L + W  P    A +E  + S A  +   +    S++  E+    T L
Sbjct: 472 QLRVKHA-NETSLSIMWQTPV---AEWEKYIISLADRDLLLIHKSLSKDAKEF--TFTDL 525

Query: 784 NFSTSYNISITTVSCGKMAAPTRNTCTTGITDPPPPDGSPNITSVSHNSVKVKFSGFEAS 843
                Y  ++T++S        +N  ++ +     P    ++   +       F+ +  +
Sbjct: 526 VPGRKYMATVTSIS-----GDLKN--SSSVKGRTVPAQVTDLHVANQGMTSSLFTNWTQA 578

Query: 844 HGPIKAYAVIL----TTGEAGHPSADVLKYTYEDFKKGA 878
            G ++ Y V+L       +    S++  +Y++   K G+
Sbjct: 579 QGDVEFYQVLLIHENVVIKNESISSETSRYSFHSLKSGS 617



 Score = 37.4 bits (85), Expect = 0.097
 Identities = 79/348 (22%), Positives = 141/348 (40%), Gaps = 51/348 (14%)

Query: 115  SSTGPSPVFDIKAVSISPTNVILTWKSNDTAASEYKYVVKHKMENEKTITVVHQPWCN-- 172
            S T PSP   +    I+ T++ +TWK          + ++    +  T   V  P+ N  
Sbjct: 1257 SRTAPSPPSLMSFADIANTSLAITWKGPPDWTDYNDFELQWLPRDALT---VFNPYNNRK 1313

Query: 173  -----ITGLRPATSYVFSITPGIGN--ETWGDPRVIKVITEPIPVSDLRVALTGVRKAAL 225
                 + GLRP  SY F++    G+  +T+  P    V T+P  + +L          A 
Sbjct: 1314 SEGRIVYGLRPGRSYQFNVKTVSGDSWKTYSKPIFGSVRTKPDKIQNLHCRPQNSTAIAC 1373

Query: 226  SW----SNGNG-TASCRVL-LESIGSHEELTQDSRLQVNISGLKPGVQYNINPYLLQSNK 279
            SW    S+ +G +  CR +  + +    +L ++  L +NI  L P  +Y      L S K
Sbjct: 1374 SWIPPDSDFDGYSIECRKMDTQEVEFSRKLEKEKSL-LNIMMLVPHKRY------LVSIK 1426

Query: 280  TKGDPLGTEGGLDASNTERSRAGSPTAPVHDESLVGPVDPSSGQQSRDTEV---LLVGLE 336
             +   + +E   D++ T   R   P  P H    V   D    + S +  V         
Sbjct: 1427 VQSAGMTSEVVEDSTITMIDR--PPPPPPHIR--VNEKDVLISKSSINFTVNCSWFSDTN 1482

Query: 337  PGTRYNATVYSQAANGTEGQPQA-------IEFRTNA-IQVFDVTAVNISATSLTLIWKV 388
               +Y   V  +A    E +P+        +E+R NA I+V+     N  A+      K 
Sbjct: 1483 GAVKYFTVVVREADGSDELKPEQQHPLPSYLEYRHNASIRVYQ---TNYFAS------KC 1533

Query: 389  SDNESSSNYTYKIHVAGETDS--SNLNVSEPRAVIPGLRSSTFYNITV 434
            ++N +S++ ++ I +  E +S     + ++ +     L+  T Y I++
Sbjct: 1534 AENPNSNSKSFNIKLGAEMESLGGKCDPTQQKFCDGPLKPHTAYRISI 1581


>gi|241896924 protein tyrosine phosphatase, receptor type, H isoform 1
            precursor [Homo sapiens]
          Length = 1115

 Score =  387 bits (994), Expect = e-107
 Identities = 305/1060 (28%), Positives = 474/1060 (44%), Gaps = 94/1060 (8%)

Query: 328  TEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQVFDVTAVNISA---TSLTL 384
            T V + GL PG+ Y  +V+ +     +G   ++   T A     V  + + A   +S+ L
Sbjct: 82   TNVTVDGLGPGSLYTCSVWVEK----DGVNSSVGTVTTATAPNPVRNLRVEAQTNSSIAL 137

Query: 385  IWKVSDNESSSNYTYKIHVAGETDSSNL-NVSEPRAVIPGLRSSTFYNITVCPVLGDIEG 443
             W+V D     N TY +   G+   +   + +     + GL     Y  ++      I  
Sbjct: 138  TWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDGLEPGCLYAFSMWVGKNGINS 197

Query: 444  TPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDA-----ESFQMHITQEGAGNSRVEI 498
            +       T   PV + RV   +T+ I L+W   D       ++ +  T +G G +    
Sbjct: 198  SRETRNATTAHNPVRNLRVEAQTTSSISLSWEVPDGTDPQNSTYCVQCTGDG-GRTETRN 256

Query: 499  TTNQSIIIGGLFPGTKY-CFEIVPKGPNGTEGASRTVCNRTVPSAVFDIHVVYVTTTEMW 557
            TT+  + + GL PG+ Y C   V K  +G   +   V + T P+ V ++ V   T + + 
Sbjct: 257  TTDTRVTVDGLGPGSLYTCSVWVEK--DGVNSSVEIVTSATAPNPVRNLTVEAQTNSSIA 314

Query: 558  LDWKSPDGASEYVYHLVIESKHGSNHTSTYDKA---ITLQGLIPGTLYNITISPEVDHVW 614
            L W+ PDG         +E         T   A   IT+  L PG LY  ++    + + 
Sbjct: 315  LTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDRLEPGCLYVFSVWVGKNGIN 374

Query: 615  GDPNSTAQYTRPSNVSNIDVSTNTTAA-TLSWQNFDDASPTYSYCLLIEKAGNSSNA-TQ 672
                +    T P+ V N+ + T T ++  L W+  D   P   Y   +E  G+     T+
Sbjct: 375  SSRETRNATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQ-DYTYWVEYTGDGGGTETR 433

Query: 673  VVTDIGITDATVTELIPGSSYTVEIFAQVGDGIKSLEPGRKSFCTDPASMASFDCEVVPK 732
              T+   T  T   L PG+ YT  ++A+      S +    S  T P ++ S   +    
Sbjct: 434  NTTN---TSVTAERLEPGTLYTFSVWAEKNGARGSRQ--NVSISTVPNAVTSLSKQDWTN 488

Query: 733  EPALVLKWTCPPGANAGFELEVSSGAWNNATHLESCSSENGTEYRTEVTY--LNFSTSYN 790
               + L+WT P G       + S   W +            +   T++T   L   + Y+
Sbjct: 489  S-TIALRWTAPQGPG-----QSSYSYWVSWVREGMTDPRTQSTSGTDITLKELEAGSLYH 542

Query: 791  ISITTVSCGKMAAPTRNTCTTGITDPPPPDGSPNITSVSHNSVKVKFSGFEASHGPIKAY 850
            +   TV   +      N+  T  T P       N T    NSV + +      H  +  Y
Sbjct: 543  L---TVWAERNEVRGYNSTLTAATAPNEVTDLQNETQTK-NSVMLWWKAPGDPHSQLYVY 598

Query: 851  AVILTTGEAGHPS---------------ADVLKYTYEDFKKGASDTYVTYLIRTEEKGRS 895
             V       GHP                 +   Y  E  + G    +  +  R +    +
Sbjct: 599  WV--QWASKGHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWAERNDVASST 656

Query: 896  QSL-SEVLKYEIDVGNESTTLGYYNGKLE---PLGSYRA--------------------- 930
            QSL +      + + +  +T   Y   L    P G Y A                     
Sbjct: 657  QSLCASTYPDTVTITSCVSTSAGYGVNLIWSCPQGGYEAFELEVGGQRGSQDRSSCGEAV 716

Query: 931  CVAGFTNITFHPQNKGLIDGAESYVSFSRYSDAVSLPQDPGVICGAVFGCIFGALVIVTV 990
             V G      +P     I      VS S     V   +  GVI GA  G +   L ++ V
Sbjct: 717  SVLGLGPARSYPATITTIWDGMKVVSHS----VVCHTESAGVIAGAFVGIL---LFLILV 769

Query: 991  GGFIFWRKKRKDAKNNEVSFSQIKPKKSKLIRVENFEAYFKKQQADSNCGFAEEYEDLKL 1050
            G  IF+ K+R   K  +     +       I  E+F  + +K + DSNCGFA++Y+ L L
Sbjct: 770  GLLIFFLKRRNKKKQQKPELRDLVFSSPGDIPAEDFADHVRKNERDSNCGFADKYQQLSL 829

Query: 1051 VGISQPKYAAELAENRGKNRYNNVLPYDISRVKLS-VQTHSTDDYINANYMPGYHSKKDF 1109
            VG SQ +  A  +EN  KNRY NVLPYD SRV L  +      DYINA++MPG  S ++F
Sbjct: 830  VGHSQSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEF 889

Query: 1110 IATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWP-SKQAQDYGDITVAM 1168
            IATQGPLP T+ DFWR+VWE+  + ++MLT C+E GR KCE YWP   Q   +G + V +
Sbjct: 890  IATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTL 949

Query: 1169 TSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQ 1228
              E V+  WT+R+  +  ++  ++  +RQFH+ +WPDHGVP + D L+ F  ++R ++ Q
Sbjct: 950  VGEEVMENWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQ 1009

Query: 1229 SPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQY 1288
            +    P +VHCSAGVGRTGT IA+D L+ Q+++E  +  +  V  +R  RPLMVQTE QY
Sbjct: 1010 TMEGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQY 1069

Query: 1289 VFLNQCVLDIVR--SQKDSKVDLIYQNTTAMTIYENLAPV 1326
            VFL+QC+L  ++  +Q  ++ ++ Y++   + IYEN+A +
Sbjct: 1070 VFLHQCILRFLQQSAQAPAEKEVPYEDVENL-IYENVAAI 1108



 Score =  139 bits (349), Expect = 2e-32
 Identities = 172/742 (23%), Positives = 285/742 (38%), Gaps = 71/742 (9%)

Query: 119 PSPVFDIKAVSISPTNVILTWKSNDTAASEYKYVVKHKMENEKTITVVHQPWCNIT--GL 176
           P+P  ++   + + +++ L+W+  D   S+          +  T    +    N+T  GL
Sbjct: 30  PNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTTATNVTVDGL 89

Query: 177 RPATSYVFSI---TPGIGNETWGDPRVIKVITEPIPVSDLRVALTGVRKAALSWSNGNG- 232
            P + Y  S+     G+ +        +   T P PV +LRV        AL+W   +G 
Sbjct: 90  GPGSLYTCSVWVEKDGVNSSVG----TVTTATAPNPVRNLRVEAQTNSSIALTWEVPDGP 145

Query: 233 ---TASCRVLLESIGSHEELTQDSRLQVNISGLKPGVQYNINPYL----------LQSNK 279
               ++  V     G        +   + + GL+PG  Y  + ++           ++  
Sbjct: 146 DPQNSTYGVEYTGDGGRAGTRSTAHTNITVDGLEPGCLYAFSMWVGKNGINSSRETRNAT 205

Query: 280 TKGDP---LGTEGGLDASNTERSRAGSPTAPVHDESLV---GPVDPSSGQQSRDTEVLLV 333
           T  +P   L  E    +S +        T P +    V   G    +  + + DT V + 
Sbjct: 206 TAHNPVRNLRVEAQTTSSISLSWEVPDGTDPQNSTYCVQCTGDGGRTETRNTTDTRVTVD 265

Query: 334 GLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQVFDVTAVNISA---TSLTLIWKVSD 390
           GL PG+ Y  +V+ +     +G   ++E  T+A     V  + + A   +S+ L W+V D
Sbjct: 266 GLGPGSLYTCSVWVEK----DGVNSSVEIVTSATAPNPVRNLTVEAQTNSSIALTWEVPD 321

Query: 391 NESSSNYTYKIHVAGETDSSNL-NVSEPRAVIPGLRSSTFYNITVCPVLGDIEGTPGFLQ 449
                N TY +   G+   +   + +     +  L     Y  +V      I  +     
Sbjct: 322 GPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDRLEPGCLYVFSVWVGKNGINSSRETRN 381

Query: 450 VHTPPVPVSDFRVTVVSTTEIGLAWSSHDAE-----SFQMHITQEGAGNSRVEITTNQSI 504
             T P PV +  +   + + I L W   D       ++ +  T +G G +    TTN S+
Sbjct: 382 ATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGG-TETRNTTNTSV 440

Query: 505 IIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTVPSAVFDIHVVYVTTTEMWLDWKSPD 564
               L PGT Y F +  +  NG  G+ + V   TVP+AV  +     T + + L W +P 
Sbjct: 441 TAERLEPGTLYTFSVWAE-KNGARGSRQNVSISTVPNAVTSLSKQDWTNSTIALRWTAPQ 499

Query: 565 GA--SEYVYHL--VIESKHGSNHTSTYDKAITLQGLIPGTLYNITISPEVDHVWGDPNST 620
           G   S Y Y +  V E        ST    ITL+ L  G+LY++T+  E + V G  ++ 
Sbjct: 500 GPGQSSYSYWVSWVREGMTDPRTQSTSGTDITLKELEAGSLYHLTVWAERNEVRGYNSTL 559

Query: 621 AQYTRPSNVSNIDVSTNTTAATLSWQNF--DDASPTYSYCLLIEKAGN-------SSNAT 671
              T P+ V+++   T T  + + W     D  S  Y Y +     G+        +N  
Sbjct: 560 TAATAPNEVTDLQNETQTKNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQANWV 619

Query: 672 QVVTDIGITDATVTELIPGSSYTVEIFAQVGDGIKSLEPGRKSFC--TDPASMASFDCEV 729
              +    T   V  L PG+ Y   ++A+  D   S +    S C  T P ++    C  
Sbjct: 620 NQTSRTNETWYKVEALEPGTLYNFTVWAERNDVASSTQ----SLCASTYPDTVTITSCVS 675

Query: 730 VPKEPALVLKWTCPPGANAGFELEVSSGAWNNATHLESCSSENGTEYRTEVTYLNFSTSY 789
                 + L W+CP G    FELEV  G    +    SC           V  L  + SY
Sbjct: 676 TSAGYGVNLIWSCPQGGYEAFELEV--GGQRGSQDRSSCGE------AVSVLGLGPARSY 727

Query: 790 NISITTVSCGKMAAPTRNTCTT 811
             +ITT+  G         C T
Sbjct: 728 PATITTIWDGMKVVSHSVVCHT 749



 Score =  104 bits (259), Expect = 6e-22
 Identities = 143/623 (22%), Positives = 241/623 (38%), Gaps = 66/623 (10%)

Query: 53  TGENGITQISSTAESFHKQNGTGTPQVETNTSEDGESSGANDSLRTPEQGSNGTDGASQK 112
           TG+ G T+  +T  +    +G G   + T  S   E  G N S+ T              
Sbjct: 68  TGDGGTTETRNTTATNVTVDGLGPGSLYT-CSVWVEKDGVNSSVGT-------------- 112

Query: 113 TPSSTGPSPVFDIKAVSISPTNVILTWKSNDTAASEYK-YVVKHKMENEK--TITVVHQP 169
             ++T P+PV +++  + + +++ LTW+  D    +   Y V++  +  +  T +  H  
Sbjct: 113 VTTATAPNPVRNLRVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAH-- 170

Query: 170 WCNIT--GLRPATSYVFSITPGIGNETWGDPRVIKVITEPIPVSDLRVALTGVRKAALSW 227
             NIT  GL P   Y FS+  G  N            T   PV +LRV        +LSW
Sbjct: 171 -TNITVDGLEPGCLYAFSMWVG-KNGINSSRETRNATTAHNPVRNLRVEAQTTSSISLSW 228

Query: 228 SNGNGT----ASCRVLLESIGSHEELTQDSRLQVNISGLKPGVQYNINPYL--------- 274
              +GT    ++  V     G   E    +  +V + GL PG  Y  + ++         
Sbjct: 229 EVPDGTDPQNSTYCVQCTGDGGRTETRNTTDTRVTVDGLGPGSLYTCSVWVEKDGVNSSV 288

Query: 275 -LQSNKTKGDP---LGTEGGLDAS---NTERSRAGSPTAPVHDESLVGPVDPSSGQQSRD 327
            + ++ T  +P   L  E   ++S     E      P    +     G    +  + +  
Sbjct: 289 EIVTSATAPNPVRNLTVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAH 348

Query: 328 TEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQVFDVTAVNISATSLTLIWK 387
           T + +  LEPG  Y  +V+    NG     +     T    V ++     + +S+ L W+
Sbjct: 349 TNITVDRLEPGCLYVFSVW-VGKNGINSSRETRNATTAPNPVRNLHMETQTNSSIALCWE 407

Query: 388 VSDNESSSNYTYKIHVAGETDSSNL-NVSEPRAVIPGLRSSTFYNITVCPVLGDIEGTPG 446
           V D     +YTY +   G+   +   N +        L   T Y  +V        G+  
Sbjct: 408 VPDGPYPQDYTYWVEYTGDGGGTETRNTTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQ 467

Query: 447 FLQVHTPPVPVSDFRVTVVSTTEIGLAWSS-----HDAESFQMHITQEGAGNSRVEITTN 501
            + + T P  V+       + + I L W++       + S+ +   +EG  + R + T+ 
Sbjct: 468 NVSISTVPNAVTSLSKQDWTNSTIALRWTAPQGPGQSSYSYWVSWVREGMTDPRTQSTSG 527

Query: 502 QSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTVPSAVFDIHVVYVTTTEMWLDWK 561
             I +  L  G+ Y   +  +  N   G + T+   T P+ V D+     T   + L WK
Sbjct: 528 TDITLKELEAGSLYHLTVWAE-RNEVRGYNSTLTAATAPNEVTDLQNETQTKNSVMLWWK 586

Query: 562 SP-DGASE-YVYHLVIESK-----------HGSNHTS-TYDKAITLQGLIPGTLYNITIS 607
           +P D  S+ YVY +   SK           +  N TS T +    ++ L PGTLYN T+ 
Sbjct: 587 APGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVW 646

Query: 608 PEVDHVWGDPNSTAQYTRPSNVS 630
            E + V     S    T P  V+
Sbjct: 647 AERNDVASSTQSLCASTYPDTVT 669



 Score = 64.7 bits (156), Expect = 6e-10
 Identities = 118/519 (22%), Positives = 193/519 (37%), Gaps = 74/519 (14%)

Query: 45  DPSVATVA---TGENGITQISSTAESFHKQNGTGTPQVETNTSEDGESSGANDSLRTPEQ 101
           DP  +T     TG+ G T+  +T ++    +G G   + T  S   E  G N S+     
Sbjct: 235 DPQNSTYCVQCTGDGGRTETRNTTDTRVTVDGLGPGSLYT-CSVWVEKDGVNSSVEI--- 290

Query: 102 GSNGTDGASQKTPSSTGPSPVFDIKAVSISPTNVILTWKSNDTAASEYK-YVVKHKMENE 160
                        S+T P+PV ++   + + +++ LTW+  D    +   Y V++  +  
Sbjct: 291 -----------VTSATAPNPVRNLTVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDGG 339

Query: 161 K--TITVVHQPWCNIT--GLRPATSYVFSITPGIGNETWGDPRVIKVITEPIPVSDLRVA 216
           +  T +  H    NIT   L P   YVFS+  G  N            T P PV +L + 
Sbjct: 340 RAGTRSTAH---TNITVDRLEPGCLYVFSVWVG-KNGINSSRETRNATTAPNPVRNLHME 395

Query: 217 LTGVRKAALSWSNGNG----TASCRVLLESIGSHEELTQDSRLQVNISGLKPGVQYNINP 272
                  AL W   +G      +  V     G   E    +   V    L+PG  Y  + 
Sbjct: 396 TQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGGTETRNTTNTSVTAERLEPGTLYTFSV 455

Query: 273 YLLQSNKTKGD----PLGTEGGLDAS--------NTERSRAGSPTAPVHDESLV------ 314
           +  + N  +G      + T      S        +T   R  +P  P             
Sbjct: 456 W-AEKNGARGSRQNVSISTVPNAVTSLSKQDWTNSTIALRWTAPQGPGQSSYSYWVSWVR 514

Query: 315 -GPVDPSSGQQSRDTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQVFDVT 373
            G  DP + Q +  T++ L  LE G+ Y+ TV+++  N   G    +   T   +V D+ 
Sbjct: 515 EGMTDPRT-QSTSGTDITLKELEAGSLYHLTVWAE-RNEVRGYNSTLTAATAPNEVTDLQ 572

Query: 374 AVNISATSLTLIWKVSDNESSSNYTYKIHVA-------GETDSSN-----LNVSEPRAVI 421
               +  S+ L WK   +  S  Y Y +  A       G+   +N        +E    +
Sbjct: 573 NETQTKNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTNETWYKV 632

Query: 422 PGLRSSTFYNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTE---IGLAWSSHD 478
             L   T YN TV     D+  +   L   T P  V+    + VST+    + L WS   
Sbjct: 633 EALEPGTLYNFTVWAERNDVASSTQSLCASTYPDTVT--ITSCVSTSAGYGVNLIWSCPQ 690

Query: 479 A--ESFQMHITQEGAGNSRVEITTNQSIIIGGLFPGTKY 515
              E+F++ +   G   S+   +  +++ + GL P   Y
Sbjct: 691 GGYEAFELEV--GGQRGSQDRSSCGEAVSVLGLGPARSY 727



 Score = 57.4 bits (137), Expect = 9e-08
 Identities = 71/327 (21%), Positives = 121/327 (37%), Gaps = 35/327 (10%)

Query: 531 SRTVCNRTVPSAVFDIHVVYVTTTEMWLDWKSPDGASEYVYHLVIESKHGSNHTSTYDKA 590
           S T      P+   ++ V   TT+ + L W+ PDG      +  ++       T T +  
Sbjct: 21  SWTGARAPAPNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTT 80

Query: 591 ---ITLQGLIPGTLYNITISPEVDHVWGDPNSTAQYTRPSNVSNIDVSTNTTAA-TLSWQ 646
              +T+ GL PG+LY  ++  E D V     +    T P+ V N+ V   T ++  L+W+
Sbjct: 81  ATNVTVDGLGPGSLYTCSVWVEKDGVNSSVGTVTTATAPNPVRNLRVEAQTNSSIALTWE 140

Query: 647 NFDDASPTYSYCLLIEKAGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQVGDGIK 706
             D   P  S    +E  G+   A    T    T+ TV  L PG  Y   ++        
Sbjct: 141 VPDGPDPQNS-TYGVEYTGDGGRAGTRST--AHTNITVDGLEPGCLYAFSMWVGKNGINS 197

Query: 707 SLEPGRKSFCTDPASMASFDCEVVPKEPALVLKWTCPPGANAGFELEVSSGAWNNATHLE 766
           S E    +   +P      + +      ++ L W  P G +             N+T+  
Sbjct: 198 SRETRNATTAHNPVRNLRVEAQTT---SSISLSWEVPDGTDP-----------QNSTYCV 243

Query: 767 SCSSENG-------TEYRTEVTYLNFSTSYNISITTVSCGKMAAPTRNTCTTGITDPPPP 819
            C+ + G       T+ R  V  L   + Y  S+     G       N+    +T    P
Sbjct: 244 QCTGDGGRTETRNTTDTRVTVDGLGPGSLYTCSVWVEKDGV------NSSVEIVTSATAP 297

Query: 820 DGSPNITSVSHNSVKVKFSGFEASHGP 846
           +   N+T  +  +  +  + +E   GP
Sbjct: 298 NPVRNLTVEAQTNSSIALT-WEVPDGP 323


>gi|241896926 protein tyrosine phosphatase, receptor type, H isoform 2
            precursor [Homo sapiens]
          Length = 937

 Score =  362 bits (929), Expect = 1e-99
 Identities = 278/930 (29%), Positives = 424/930 (45%), Gaps = 86/930 (9%)

Query: 454  PVPVSDFRVTVVSTTEIGLAWSSHDA-----ESFQMHITQEGAGNSRVEITTNQSIIIGG 508
            P P  +  V   +T+ I L+W   D       ++ +  T +G G +    TT  ++ + G
Sbjct: 30   PNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDG-GTTETRNTTATNVTVDG 88

Query: 509  LFPGTKY-CFEIVPKGPNGTEGASRTVCNRTVPSAVFDIHVVYVTTTEMWLDWKSPDGAS 567
            L PG+ Y C   V K  +G   +  TV   T P+ V ++ V   T + + L W+ PDG  
Sbjct: 89   LGPGSLYTCSVWVEK--DGVNSSVGTVTTATAPNPVRNLTVEAQTNSSIALTWEVPDGPD 146

Query: 568  EYVYHLVIESKHGSNHTSTYDKA---ITLQGLIPGTLYNITISPEVDHVWGDPNSTAQYT 624
                   +E         T   A   IT+  L PG LY  ++    + +     +    T
Sbjct: 147  PQNSTYGVEYTGDGGRAGTRSTAHTNITVDRLEPGCLYVFSVWVGKNGINSSRETRNATT 206

Query: 625  RPSNVSNIDVSTNTTAA-TLSWQNFDDASPTYSYCLLIEKAGNSSNA-TQVVTDIGITDA 682
             P+ V N+ + T T ++  L W+  D   P   Y   +E  G+     T+  T+   T  
Sbjct: 207  APNPVRNLHMETQTNSSIALCWEVPDGPYPQ-DYTYWVEYTGDGGGTETRNTTN---TSV 262

Query: 683  TVTELIPGSSYTVEIFAQVGDGIKSLEPGRKSFCTDPASMASFDCEVVPKEPALVLKWTC 742
            T   L PG+ YT  ++A+      S +    S  T P ++ S   +       + L+WT 
Sbjct: 263  TAERLEPGTLYTFSVWAEKNGARGSRQ--NVSISTVPNAVTSLSKQDWTNS-TIALRWTA 319

Query: 743  PPGANAGFELEVSSGAWNNATHLESCSSENGTEYRTEVTY--LNFSTSYNISITTVSCGK 800
            P G       + S   W +            +   T++T   L   + Y++   TV   +
Sbjct: 320  PQGPG-----QSSYSYWVSWVREGMTDPRTQSTSGTDITLKELEAGSLYHL---TVWAER 371

Query: 801  MAAPTRNTCTTGITDPPPPDGSPNITSVSHNSVKVKFSGFEASHGPIKAYAVILTTGEAG 860
                  N+  T  T P       N T    NSV + +      H  +  Y V       G
Sbjct: 372  NEVRGYNSTLTAATAPNEVTDLQNETQTK-NSVMLWWKAPGDPHSQLYVYWV--QWASKG 428

Query: 861  HPS---------------ADVLKYTYEDFKKGASDTYVTYLIRTEEKGRSQSL-SEVLKY 904
            HP                 +   Y  E  + G    +  +  R +    +QSL +     
Sbjct: 429  HPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWAERNDVASSTQSLCASTYPD 488

Query: 905  EIDVGNESTTLGYYNGKLE---PLGSYRA---------------------CVAGFTNITF 940
             + + +  +T   Y   L    P G Y A                      V G      
Sbjct: 489  TVTITSCVSTSAGYGVNLIWSCPQGGYEAFELEVGGQRGSQDRSSCGEAVSVLGLGPARS 548

Query: 941  HPQNKGLIDGAESYVSFSRYSDAVSLPQDPGVICGAVFGCIFGALVIVTVGGFIFWRKKR 1000
            +P     I      VS S     V   +  GVI GA  G +   L ++ VG  IF+ K+R
Sbjct: 549  YPATITTIWDGMKVVSHS----VVCHTESAGVIAGAFVGIL---LFLILVGLLIFFLKRR 601

Query: 1001 KDAKNNEVSFSQIKPKKSKLIRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQPKYAA 1060
               K  +     +       I  E+F  + +K + DSNCGFA++Y+ L LVG SQ +  A
Sbjct: 602  NKKKQQKPELRDLVFSSPGDIPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVA 661

Query: 1061 ELAENRGKNRYNNVLPYDISRVKLS-VQTHSTDDYINANYMPGYHSKKDFIATQGPLPNT 1119
              +EN  KNRY NVLPYD SRV L  +      DYINA++MPG  S ++FIATQGPLP T
Sbjct: 662  SASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQT 721

Query: 1120 LKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWP-SKQAQDYGDITVAMTSEIVLPEWT 1178
            + DFWR+VWE+  + ++MLT C+E GR KCE YWP   Q   +G + V +  E V+  WT
Sbjct: 722  VGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWT 781

Query: 1179 IRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILVH 1238
            +R+  +  ++  ++  +RQFH+ +WPDHGVP + D L+ F  ++R ++ Q+    P +VH
Sbjct: 782  VRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVH 841

Query: 1239 CSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDI 1298
            CSAGVGRTGT IA+D L+ Q+++E  +  +  V  +R  RPLMVQTE QYVFL+QC+L  
Sbjct: 842  CSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRF 901

Query: 1299 VR--SQKDSKVDLIYQNTTAMTIYENLAPV 1326
            ++  +Q  ++ ++ Y++   + IYEN+A +
Sbjct: 902  LQQSAQAPAEKEVPYEDVENL-IYENVAAI 930



 Score =  123 bits (309), Expect = 1e-27
 Identities = 127/505 (25%), Positives = 199/505 (39%), Gaps = 36/505 (7%)

Query: 328 TEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQVFDVTAVNISATSLTLIWK 387
           T V + GL PG+ Y  +V+ +  +G       +   T    V ++T    + +S+ L W+
Sbjct: 82  TNVTVDGLGPGSLYTCSVWVEK-DGVNSSVGTVTTATAPNPVRNLTVEAQTNSSIALTWE 140

Query: 388 VSDNESSSNYTYKIHVAGETDSSNL-NVSEPRAVIPGLRSSTFYNITVCPVLGDIEGTPG 446
           V D     N TY +   G+   +   + +     +  L     Y  +V      I  +  
Sbjct: 141 VPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDRLEPGCLYVFSVWVGKNGINSSRE 200

Query: 447 FLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDAE-----SFQMHITQEGAGNSRVEITTN 501
                T P PV +  +   + + I L W   D       ++ +  T +G G +    TTN
Sbjct: 201 TRNATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGG-TETRNTTN 259

Query: 502 QSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTVPSAVFDIHVVYVTTTEMWLDWK 561
            S+    L PGT Y F +  +  NG  G+ + V   TVP+AV  +     T + + L W 
Sbjct: 260 TSVTAERLEPGTLYTFSVWAE-KNGARGSRQNVSISTVPNAVTSLSKQDWTNSTIALRWT 318

Query: 562 SPDGA--SEYVYHL--VIESKHGSNHTSTYDKAITLQGLIPGTLYNITISPEVDHVWGDP 617
           +P G   S Y Y +  V E        ST    ITL+ L  G+LY++T+  E + V G  
Sbjct: 319 APQGPGQSSYSYWVSWVREGMTDPRTQSTSGTDITLKELEAGSLYHLTVWAERNEVRGYN 378

Query: 618 NSTAQYTRPSNVSNIDVSTNTTAATLSWQNF--DDASPTYSYCLLIEKAGN-------SS 668
           ++    T P+ V+++   T T  + + W     D  S  Y Y +     G+        +
Sbjct: 379 STLTAATAPNEVTDLQNETQTKNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQA 438

Query: 669 NATQVVTDIGITDATVTELIPGSSYTVEIFAQVGDGIKSLEPGRKSFC--TDPASMASFD 726
           N     +    T   V  L PG+ Y   ++A+  D   S +    S C  T P ++    
Sbjct: 439 NWVNQTSRTNETWYKVEALEPGTLYNFTVWAERNDVASSTQ----SLCASTYPDTVTITS 494

Query: 727 CEVVPKEPALVLKWTCPPGANAGFELEVSSGAWNNATHLESCSSENGTEYRTEVTYLNFS 786
           C        + L W+CP G    FELEV  G    +    SC           V  L  +
Sbjct: 495 CVSTSAGYGVNLIWSCPQGGYEAFELEV--GGQRGSQDRSSCGE------AVSVLGLGPA 546

Query: 787 TSYNISITTVSCGKMAAPTRNTCTT 811
            SY  +ITT+  G         C T
Sbjct: 547 RSYPATITTIWDGMKVVSHSVVCHT 571



 Score =  108 bits (271), Expect = 3e-23
 Identities = 112/469 (23%), Positives = 195/469 (41%), Gaps = 39/469 (8%)

Query: 371 DVTAVNISATSLTLIWKVSDNESSSNYTYKIHVAGETDSSNL-NVSEPRAVIPGLRSSTF 429
           ++T    + +S++L W+V D   S N  Y +   G+  ++   N +     + GL   + 
Sbjct: 35  NLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTTATNVTVDGLGPGSL 94

Query: 430 YNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDA-----ESFQM 484
           Y  +V      +  + G +   T P PV +  V   + + I L W   D       ++ +
Sbjct: 95  YTCSVWVEKDGVNSSVGTVTTATAPNPVRNLTVEAQTNSSIALTWEVPDGPDPQNSTYGV 154

Query: 485 HITQEGAGNSRVEITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTVPSAVF 544
             T +G G +    T + +I +  L PG  Y F  V  G NG   +  T    T P+ V 
Sbjct: 155 EYTGDG-GRAGTRSTAHTNITVDRLEPGCLYVFS-VWVGKNGINSSRETRNATTAPNPVR 212

Query: 545 DIHVVYVTTTEMWLDWKSPDG--ASEYVYHLVIESKHGSNHT-STYDKAITLQGLIPGTL 601
           ++H+   T + + L W+ PDG    +Y Y +      G   T +T + ++T + L PGTL
Sbjct: 213 NLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGGTETRNTTNTSVTAERLEPGTL 272

Query: 602 YNITISPEVDHVWGDPNSTAQYTRPSNVSNIDVS--TNTTAATLSWQNFDDASPTYSYCL 659
           Y  ++  E +   G   + +  T P+ V+++     TN+T A            +YSY +
Sbjct: 273 YTFSVWAEKNGARGSRQNVSISTVPNAVTSLSKQDWTNSTIALRWTAPQGPGQSSYSYWV 332

Query: 660 LIEKAGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQVGD--GIKSLEPGRKSFCT 717
              + G +   TQ  +    TD T+ EL  GS Y + ++A+  +  G  S      +  T
Sbjct: 333 SWVREGMTDPRTQSTSG---TDITLKELEAGSLYHLTVWAERNEVRGYNS----TLTAAT 385

Query: 718 DPASMASFDCEVVPKEPALVLKWTCPPGANAGFELEVSSGAWNNATH-----------LE 766
            P  +     E   K  +++L W  P   ++  +L V    W +  H           + 
Sbjct: 386 APNEVTDLQNETQTKN-SVMLWWKAPGDPHS--QLYVYWVQWASKGHPRRGQDPQANWVN 442

Query: 767 SCSSENGTEYRTEVTYLNFSTSYNISITTVSCGKMAAPTRNTCTTGITD 815
             S  N T Y+ E   L   T YN ++       +A+ T++ C +   D
Sbjct: 443 QTSRTNETWYKVEA--LEPGTLYNFTV-WAERNDVASSTQSLCASTYPD 488



 Score = 64.3 bits (155), Expect = 7e-10
 Identities = 115/508 (22%), Positives = 189/508 (37%), Gaps = 71/508 (13%)

Query: 53  TGENGITQISSTAESFHKQNGTGTPQVETNTSEDGESSGANDSLRTPEQGSNGTDGASQK 112
           TG+ G T+  +T  +    +G G   + T  S   E  G N S+ T              
Sbjct: 68  TGDGGTTETRNTTATNVTVDGLGPGSLYT-CSVWVEKDGVNSSVGT-------------- 112

Query: 113 TPSSTGPSPVFDIKAVSISPTNVILTWKSNDTAASEYK-YVVKHKMENEK--TITVVHQP 169
             ++T P+PV ++   + + +++ LTW+  D    +   Y V++  +  +  T +  H  
Sbjct: 113 VTTATAPNPVRNLTVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAH-- 170

Query: 170 WCNIT--GLRPATSYVFSITPGIGNETWGDPRVIKVITEPIPVSDLRVALTGVRKAALSW 227
             NIT   L P   YVFS+  G  N            T P PV +L +        AL W
Sbjct: 171 -TNITVDRLEPGCLYVFSVWVG-KNGINSSRETRNATTAPNPVRNLHMETQTNSSIALCW 228

Query: 228 SNGNG----TASCRVLLESIGSHEELTQDSRLQVNISGLKPGVQYNINPYLLQSNKTKGD 283
              +G      +  V     G   E    +   V    L+PG  Y  + +  + N  +G 
Sbjct: 229 EVPDGPYPQDYTYWVEYTGDGGGTETRNTTNTSVTAERLEPGTLYTFSVW-AEKNGARGS 287

Query: 284 ----PLGTEGGLDAS--------NTERSRAGSPTAPVHDESLV-------GPVDPSSGQQ 324
                + T      S        +T   R  +P  P              G  DP + Q 
Sbjct: 288 RQNVSISTVPNAVTSLSKQDWTNSTIALRWTAPQGPGQSSYSYWVSWVREGMTDPRT-QS 346

Query: 325 SRDTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQVFDVTAVNISATSLTL 384
           +  T++ L  LE G+ Y+ TV+++  N   G    +   T   +V D+     +  S+ L
Sbjct: 347 TSGTDITLKELEAGSLYHLTVWAE-RNEVRGYNSTLTAATAPNEVTDLQNETQTKNSVML 405

Query: 385 IWKVSDNESSSNYTYKIHVA-------GETDSSN-----LNVSEPRAVIPGLRSSTFYNI 432
            WK   +  S  Y Y +  A       G+   +N        +E    +  L   T YN 
Sbjct: 406 WWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNF 465

Query: 433 TVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTE---IGLAWSSHDA--ESFQMHIT 487
           TV     D+  +   L   T P  V+    + VST+    + L WS      E+F++ + 
Sbjct: 466 TVWAERNDVASSTQSLCASTYPDTVT--ITSCVSTSAGYGVNLIWSCPQGGYEAFELEV- 522

Query: 488 QEGAGNSRVEITTNQSIIIGGLFPGTKY 515
             G   S+   +  +++ + GL P   Y
Sbjct: 523 -GGQRGSQDRSSCGEAVSVLGLGPARSY 549



 Score = 55.1 bits (131), Expect = 5e-07
 Identities = 58/220 (26%), Positives = 91/220 (41%), Gaps = 12/220 (5%)

Query: 531 SRTVCNRTVPSAVFDIHVVYVTTTEMWLDWKSPDGASEYVYHLVIESKHGSNHTSTYDKA 590
           S T      P+   ++ V   TT+ + L W+ PDG      +  ++       T T +  
Sbjct: 21  SWTGARAPAPNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTT 80

Query: 591 ---ITLQGLIPGTLYNITISPEVDHVWGDPNSTAQYTRPSNVSNIDVSTNTTAA-TLSWQ 646
              +T+ GL PG+LY  ++  E D V     +    T P+ V N+ V   T ++  L+W+
Sbjct: 81  ATNVTVDGLGPGSLYTCSVWVEKDGVNSSVGTVTTATAPNPVRNLTVEAQTNSSIALTWE 140

Query: 647 NFDDASPTYSYCLLIEKAGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQVG-DGI 705
             D   P  S    +E  G+   A    T    T+ TV  L PG  Y   ++  VG +GI
Sbjct: 141 VPDGPDPQNS-TYGVEYTGDGGRAGTRST--AHTNITVDRLEPGCLYVFSVW--VGKNGI 195

Query: 706 KSLEPGRKSFCTDPASMASFDCEVVPKEPALVLKWTCPPG 745
            S    R +  T P  + +   E      ++ L W  P G
Sbjct: 196 NSSRETRNA-TTAPNPVRNLHME-TQTNSSIALCWEVPDG 233



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 82/388 (21%), Positives = 152/388 (39%), Gaps = 44/388 (11%)

Query: 102 GSNGTDGASQKTPSSTGPSPVFDIKAVSISPTNVILTWKSNDTA-ASEYKYVVKHKMENE 160
           G NG + + +   ++T P+PV ++   + + +++ L W+  D     +Y Y V++  +  
Sbjct: 191 GKNGINSSRETRNATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGG 250

Query: 161 KTITVVHQPWCNITG--LRPATSYVFSITPGIGNETWGDPRVIKVITEPIPVSDLRVALT 218
            T T  +    ++T   L P T Y FS+     N   G  + + + T P  V+ L     
Sbjct: 251 GTETR-NTTNTSVTAERLEPGTLYTFSVWAE-KNGARGSRQNVSISTVPNAVTSLSKQDW 308

Query: 219 GVRKAALSWS--NGNGTASCRVLLESI--GSHEELTQD-SRLQVNISGLKPGVQYNINPY 273
                AL W+   G G +S    +  +  G  +  TQ  S   + +  L+ G  Y++  +
Sbjct: 309 TNSTIALRWTAPQGPGQSSYSYWVSWVREGMTDPRTQSTSGTDITLKELEAGSLYHLTVW 368

Query: 274 LLQS-----NKTKGDPLGTEGGLDASNTERSRAG------SPTAPVHDESLVGPVD---- 318
             ++     N T           D  N  +++        +P  P H +  V  V     
Sbjct: 369 AERNEVRGYNSTLTAATAPNEVTDLQNETQTKNSVMLWWKAPGDP-HSQLYVYWVQWASK 427

Query: 319 --PSSGQ-----------QSRDTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTN 365
             P  GQ           ++ +T   +  LEPGT YN TV+++  N      Q++   T 
Sbjct: 428 GHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWAE-RNDVASSTQSLCASTY 486

Query: 366 AIQVFDVTAVNISA-TSLTLIWKVSDNESSSNYTYKIHVAGETDSSNLNVSEPRAVIPGL 424
              V   + V+ SA   + LIW        +   +++ V G+  S + +       + GL
Sbjct: 487 PDTVTITSCVSTSAGYGVNLIWSCPQGGYEA---FELEVGGQRGSQDRSSCGEAVSVLGL 543

Query: 425 RSSTFYNITVCPVLGDIEGTPGFLQVHT 452
             +  Y  T+  +   ++     +  HT
Sbjct: 544 GPARSYPATITTIWDGMKVVSHSVVCHT 571


>gi|4506323 receptor-type protein tyrosine phosphatase O isoform b
            precursor [Homo sapiens]
          Length = 1188

 Score =  284 bits (727), Expect = 3e-76
 Identities = 235/776 (30%), Positives = 379/776 (48%), Gaps = 109/776 (14%)

Query: 625  RPSNVSNIDVSTNTTAA---TLSWQNFDDASPTYSYCLLIEKAGNSSNATQVVTDIGITD 681
            +P +VS + V ++TTA    T S +N++    +       ++  +     Q  T +  + 
Sbjct: 435  KPQHVS-VHVLSSTTALMSWTSSQENYNSTIVSVVSLTCQKQKESQRLEKQYCTQVNSSK 493

Query: 682  ATVTELIPGSSYTVEIFAQVGDGIKSLEPGRKSFCTDPASMASF-----DCEVVPKEP-A 735
              +  L+PG+ Y V I+ + G  I     G  S   DP + A       D  + P  P A
Sbjct: 494  PIIENLVPGAQYQVVIYLRKGPLI-----GPPS---DPVTFAIVPTGIKDLMLYPLGPTA 545

Query: 736  LVLKWTCPP-GANAGFELEVSSGAWNNATHLESCSSENGTEYRTEVTYLNFSTS------ 788
            +VL WT P  G    + +E+    +N AT     +SE  T Y    T ++ + S      
Sbjct: 546  VVLSWTRPYLGVFRKYVVEMFY--FNPAT----MTSEWTTYYEIAAT-VSLTASVRIANL 598

Query: 789  -----YNISITTVSCGKMAAPTRNTCTTGITDPPPPDGSPNITSVSHNSVKVKFSGF--- 840
                 YN  +T V+ G       ++ T      P    +P ITSV + +  +  S     
Sbjct: 599  LPAWYYNFRVTMVTWGDPELSCCDSSTISFITAPV---APEITSVEYFNSLLYISWTYGD 655

Query: 841  ---EASHGPIKAYAVI--------------LTTGEAGHPSADVLKYTYEDFKKGASDTYV 883
               + SH  +  + V+              + T     P  D+   +     +  S+T +
Sbjct: 656  DTTDLSHSRMLHWMVVAEGKKKIKKSVTRNVMTAILSLPPGDIYNLSVTACTERGSNTSM 715

Query: 884  TYLIRTEEKGRSQSLSEVLKYEIDVGN---ESTTLGYYNGKLEPLGS-YRACVAGFTNIT 939
              L++ E     +SL  V K +  V     E     ++    + +GS  +  +     ++
Sbjct: 716  LRLVKLEP-APPKSLFAVNKTQTSVTLLWVEEGVADFFEVFCQQVGSSQKTKLQEPVAVS 774

Query: 940  FHPQNKGLIDGAESY----VSFSRYSDAVSL---------PQDPGVICGAVFGCIFGALV 986
             H      +  A +Y     SFS  S +V             +P V+  +V   +   L+
Sbjct: 775  SHVVTISSLLPATAYNCSVTSFSHDSPSVPTFIAVSTMVTEMNPNVVVISVLAILSTLLI 834

Query: 987  IVTVGGFIFWRKK-----RKDAKNNEVSFSQIKP-------------KKSKL---IRVEN 1025
             + +   I  RKK     R+      V+F+ ++              KK KL   +++++
Sbjct: 835  GLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGKLPYNWSKNGLKKRKLTNPVQLDD 894

Query: 1026 FEAYFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKL- 1084
            F+AY K    DS+  F+ ++E+LKL+G+  P +AA+L  NR KNRY N+LPYD SRV+L 
Sbjct: 895  FDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLV 954

Query: 1085 SVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQ 1144
            S+      DYINANY+PGY+S +++IATQGPLP T  DFW+MV ++    I+MLT+C E+
Sbjct: 955  SMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEK 1014

Query: 1145 GRTKCEEYWP-SKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSW 1203
             R KC+ YWP +++   YGDITV M SE    +W  R F +      E   +  F++T+W
Sbjct: 1015 RRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRIN--YADEMQDVMHFNYTAW 1072

Query: 1204 PDHGVP--DTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIEN 1261
            PDHGVP  +  + ++ F ++VR    +S  + P+++HCSAGVGRTGTFIA+DRL+  I +
Sbjct: 1073 PDHGVPTANAAESILQFVHMVRQQATKS--KGPMIIHCSAGVGRTGTFIALDRLLQHIRD 1130

Query: 1262 ENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCV--LDIVRSQKDSKVDLIYQNTT 1315
               VD+ G+V ++R +R  MVQTE+QY+F++QCV  + + + Q+    D+IY+N +
Sbjct: 1131 HEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCISDVIYENVS 1186



 Score = 36.6 bits (83), Expect = 0.17
 Identities = 91/410 (22%), Positives = 158/410 (38%), Gaps = 68/410 (16%)

Query: 462 VTVVSTTEIGLAWSSHDAESFQMHIT-------QEGAGNSRVEI-----TTNQSIIIGGL 509
           V V+S+T   ++W+S   E++   I        Q+   + R+E        +   II  L
Sbjct: 441 VHVLSSTTALMSWTSSQ-ENYNSTIVSVVSLTCQKQKESQRLEKQYCTQVNSSKPIIENL 499

Query: 510 FPGTKYCFEI-VPKGPNGTEGASRTVCNRTVPSAVFDIHVVYVTTTEMWLDWKSP--DGA 566
            PG +Y   I + KGP      S  V    VP+ + D+ +  +  T + L W  P     
Sbjct: 500 VPGAQYQVVIYLRKGPL-IGPPSDPVTFAIVPTGIKDLMLYPLGPTAVVLSWTRPYLGVF 558

Query: 567 SEYVYHLVI--ESKHGSNHTSTYDKAITLQ--------GLIPGTLYNITISPEVDHVWGD 616
            +YV  +     +   S  T+ Y+ A T+          L+P   YN  ++      WGD
Sbjct: 559 RKYVVEMFYFNPATMTSEWTTYYEIAATVSLTASVRIANLLPAWYYNFRVTMVT---WGD 615

Query: 617 P------NSTAQY-TRPSNVSNIDVSTNTTAATLSWQNFDDASP-TYSYCL--LIEKAGN 666
           P      +ST  + T P       V    +   +SW   DD +  ++S  L  ++   G 
Sbjct: 616 PELSCCDSSTISFITAPVAPEITSVEYFNSLLYISWTYGDDTTDLSHSRMLHWMVVAEGK 675

Query: 667 SSNATQVVTDIGITDATVTELIPGSSYTVEIFAQVGDG-------IKSLEPGRKSFCTDP 719
                 V  ++      +  L PG  Y + + A    G       +  LEP        P
Sbjct: 676 KKIKKSVTRNVM---TAILSLPPGDIYNLSVTACTERGSNTSMLRLVKLEPA------PP 726

Query: 720 ASMASFDCEVVPKEPALVLKWTCPPGANAGFELEVSSGAWNNATHLESCSSENGTEYRTE 779
            S+ +    V   + ++ L W    G    FE+       +  T L+   + +   +   
Sbjct: 727 KSLFA----VNKTQTSVTLLWV-EEGVADFFEVFCQQVGSSQKTKLQEPVAVSS--HVVT 779

Query: 780 VTYLNFSTSYNISITTVSCGKMAAPTRNTCTTGITDPPPPDGSPNITSVS 829
           ++ L  +T+YN S+T+ S    + PT    +T +T+      +PN+  +S
Sbjct: 780 ISSLLPATAYNCSVTSFSHDSPSVPTFIAVSTMVTEM-----NPNVVVIS 824



 Score = 35.8 bits (81), Expect = 0.28
 Identities = 41/160 (25%), Positives = 67/160 (41%), Gaps = 18/160 (11%)

Query: 325 SRDTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQVFDVTAVNISATSLTL 384
           +R+    ++ L PG  YN +V +    G+      +  +        + AVN + TS+TL
Sbjct: 683 TRNVMTAILSLPPGDIYNLSVTACTERGSNTSMLRL-VKLEPAPPKSLFAVNKTQTSVTL 741

Query: 385 IWKVSDNESSSNYTYKIHVAGETDSSNLNVSEPRAV------IPGLRSSTFYNITVCPVL 438
           +W     E  +++ +++       S    + EP AV      I  L  +T YN +V    
Sbjct: 742 LWV---EEGVADF-FEVFCQQVGSSQKTKLQEPVAVSSHVVTISSLLPATAYNCSVTSFS 797

Query: 439 GDIEGTPGFLQVHT------PPVPVSDFRVTVVSTTEIGL 472
            D    P F+ V T      P V V    + ++ST  IGL
Sbjct: 798 HDSPSVPTFIAVSTMVTEMNPNVVVISV-LAILSTLLIGL 836



 Score = 34.3 bits (77), Expect = 0.82
 Identities = 69/291 (23%), Positives = 103/291 (35%), Gaps = 49/291 (16%)

Query: 119 PSPVFDIKAVSISPTNVILTWKSNDTAASEYKYVVKHKMENEKTI------------TVV 166
           P+ + D+    + PT V+L+W +        KYVV+    N  T+            TV 
Sbjct: 530 PTGIKDLMLYPLGPTAVVLSW-TRPYLGVFRKYVVEMFYFNPATMTSEWTTYYEIAATVS 588

Query: 167 HQPWCNITGLRPATSYVFSITPGIGNETWGDPRV-------IKVITEPIPVSDLRVALTG 219
                 I  L PA  Y F +T      TWGDP +       I  IT P+      V    
Sbjct: 589 LTASVRIANLLPAWYYNFRVT----MVTWGDPELSCCDSSTISFITAPVAPEITSVEYFN 644

Query: 220 VRKAALSWSNGNGTASCRVLLESIGSHEELTQDSRLQVNISGLKPGVQYNINPYLLQSNK 279
                +SW+ G+ T           SH  +     +      +K  V  N+   +L  + 
Sbjct: 645 -SLLYISWTYGDDTTDL--------SHSRMLHWMVVAEGKKKIKKSVTRNVMTAIL--SL 693

Query: 280 TKGDPLGTEGGLDASNTERSRAGSPTAPVHDESLVGPVDPSS--GQQSRDTEVLLVGLEP 337
             GD        + S T  +  GS T+ +    L  P  P S        T V L+ +E 
Sbjct: 694 PPGDI------YNLSVTACTERGSNTSMLRLVKL-EPAPPKSLFAVNKTQTSVTLLWVEE 746

Query: 338 GTRYNATVYSQAANGTE----GQPQAIEFRTNAI-QVFDVTAVNISATSLT 383
           G      V+ Q    ++     +P A+      I  +   TA N S TS +
Sbjct: 747 GVADFFEVFCQQVGSSQKTKLQEPVAVSSHVVTISSLLPATAYNCSVTSFS 797


>gi|13677220 receptor-type protein tyrosine phosphatase O isoform d
            precursor [Homo sapiens]
          Length = 377

 Score =  279 bits (714), Expect = 1e-74
 Identities = 145/334 (43%), Positives = 220/334 (65%), Gaps = 14/334 (4%)

Query: 991  GGFIFWRKKRKDAKNNEVSFSQIKPKKSKL---IRVENFEAYFKKQQADSNCGFAEEYED 1047
            G F+ +    +D K    ++S+   KK KL   +++++F+AY K    DS+  F+ ++E+
Sbjct: 47   GTFVNFASLERDGKL-PYNWSKNGLKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEE 105

Query: 1048 LKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKL-SVQTHSTDDYINANYMPGYHSK 1106
            LKL+G+  P +AA+L  NR KNRY N+LPYD SRV+L S+      DYINANY+PGY+S 
Sbjct: 106  LKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSP 165

Query: 1107 KDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWP-SKQAQDYGDIT 1165
            +++IATQGPLP T  DFW+MV ++    I+MLT+C E+ R KC+ YWP +++   YGDIT
Sbjct: 166  QEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDIT 225

Query: 1166 VAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVP--DTTDLLINFRYLVR 1223
            V M SE    +W  R F +      E   +  F++T+WPDHGVP  +  + ++ F ++VR
Sbjct: 226  VEMISEEEQDDWACRHFRIN--YADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVR 283

Query: 1224 DYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQ 1283
                +S  + P+++HCSAGVGRTGTFIA+DRL+  I +   VD+ G+V ++R +R  MVQ
Sbjct: 284  QQATKS--KGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQ 341

Query: 1284 TEDQYVFLNQCV--LDIVRSQKDSKVDLIYQNTT 1315
            TE+QY+F++QCV  + + + Q+    D+IY+N +
Sbjct: 342  TEEQYIFIHQCVQLMWMKKKQQFCISDVIYENVS 375


>gi|13677216 receptor-type protein tyrosine phosphatase O isoform d
            precursor [Homo sapiens]
          Length = 377

 Score =  279 bits (714), Expect = 1e-74
 Identities = 145/334 (43%), Positives = 220/334 (65%), Gaps = 14/334 (4%)

Query: 991  GGFIFWRKKRKDAKNNEVSFSQIKPKKSKL---IRVENFEAYFKKQQADSNCGFAEEYED 1047
            G F+ +    +D K    ++S+   KK KL   +++++F+AY K    DS+  F+ ++E+
Sbjct: 47   GTFVNFASLERDGKL-PYNWSKNGLKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEE 105

Query: 1048 LKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKL-SVQTHSTDDYINANYMPGYHSK 1106
            LKL+G+  P +AA+L  NR KNRY N+LPYD SRV+L S+      DYINANY+PGY+S 
Sbjct: 106  LKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSP 165

Query: 1107 KDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWP-SKQAQDYGDIT 1165
            +++IATQGPLP T  DFW+MV ++    I+MLT+C E+ R KC+ YWP +++   YGDIT
Sbjct: 166  QEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDIT 225

Query: 1166 VAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVP--DTTDLLINFRYLVR 1223
            V M SE    +W  R F +      E   +  F++T+WPDHGVP  +  + ++ F ++VR
Sbjct: 226  VEMISEEEQDDWACRHFRIN--YADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVR 283

Query: 1224 DYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQ 1283
                +S  + P+++HCSAGVGRTGTFIA+DRL+  I +   VD+ G+V ++R +R  MVQ
Sbjct: 284  QQATKS--KGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQ 341

Query: 1284 TEDQYVFLNQCV--LDIVRSQKDSKVDLIYQNTT 1315
            TE+QY+F++QCV  + + + Q+    D+IY+N +
Sbjct: 342  TEEQYIFIHQCVQLMWMKKKQQFCISDVIYENVS 375


>gi|13677222 receptor-type protein tyrosine phosphatase O isoform c
            precursor [Homo sapiens]
          Length = 405

 Score =  278 bits (711), Expect = 3e-74
 Identities = 140/309 (45%), Positives = 209/309 (67%), Gaps = 13/309 (4%)

Query: 1016 KKSKL---IRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYN 1072
            KK KL   +++++F+AY K    DS+  F+ ++E+LKL+G+  P +AA+L  NR KNRY 
Sbjct: 99   KKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYT 158

Query: 1073 NVLPYDISRVKL-SVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKN 1131
            N+LPYD SRV+L S+      DYINANY+PGY+S +++IATQGPLP T  DFW+MV ++ 
Sbjct: 159  NILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQK 218

Query: 1132 VYAIIMLTKCVEQGRTKCEEYWP-SKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTS 1190
               I+MLT+C E+ R KC+ YWP +++   YGDITV M SE    +W  R F +      
Sbjct: 219  SQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRIN--YAD 276

Query: 1191 ESHPLRQFHFTSWPDHGVP--DTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGT 1248
            E   +  F++T+WPDHGVP  +  + ++ F ++VR    +S  + P+++HCSAGVGRTGT
Sbjct: 277  EMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKS--KGPMIIHCSAGVGRTGT 334

Query: 1249 FIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCV--LDIVRSQKDSK 1306
            FIA+DRL+  I +   VD+ G+V ++R +R  MVQTE+QY+F++QCV  + + + Q+   
Sbjct: 335  FIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCI 394

Query: 1307 VDLIYQNTT 1315
             D+IY+N +
Sbjct: 395  SDVIYENVS 403


>gi|13677218 receptor-type protein tyrosine phosphatase O isoform c
            precursor [Homo sapiens]
          Length = 405

 Score =  278 bits (711), Expect = 3e-74
 Identities = 140/309 (45%), Positives = 209/309 (67%), Gaps = 13/309 (4%)

Query: 1016 KKSKL---IRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYN 1072
            KK KL   +++++F+AY K    DS+  F+ ++E+LKL+G+  P +AA+L  NR KNRY 
Sbjct: 99   KKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYT 158

Query: 1073 NVLPYDISRVKL-SVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKN 1131
            N+LPYD SRV+L S+      DYINANY+PGY+S +++IATQGPLP T  DFW+MV ++ 
Sbjct: 159  NILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQK 218

Query: 1132 VYAIIMLTKCVEQGRTKCEEYWP-SKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTS 1190
               I+MLT+C E+ R KC+ YWP +++   YGDITV M SE    +W  R F +      
Sbjct: 219  SQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRIN--YAD 276

Query: 1191 ESHPLRQFHFTSWPDHGVP--DTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGT 1248
            E   +  F++T+WPDHGVP  +  + ++ F ++VR    +S  + P+++HCSAGVGRTGT
Sbjct: 277  EMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKS--KGPMIIHCSAGVGRTGT 334

Query: 1249 FIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCV--LDIVRSQKDSK 1306
            FIA+DRL+  I +   VD+ G+V ++R +R  MVQTE+QY+F++QCV  + + + Q+   
Sbjct: 335  FIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCI 394

Query: 1307 VDLIYQNTT 1315
             D+IY+N +
Sbjct: 395  SDVIYENVS 403


>gi|13677214 receptor-type protein tyrosine phosphatase O isoform a
            precursor [Homo sapiens]
          Length = 1216

 Score =  278 bits (711), Expect = 3e-74
 Identities = 140/309 (45%), Positives = 209/309 (67%), Gaps = 13/309 (4%)

Query: 1016 KKSKL---IRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYN 1072
            KK KL   +++++F+AY K    DS+  F+ ++E+LKL+G+  P +AA+L  NR KNRY 
Sbjct: 910  KKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYT 969

Query: 1073 NVLPYDISRVKL-SVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKN 1131
            N+LPYD SRV+L S+      DYINANY+PGY+S +++IATQGPLP T  DFW+MV ++ 
Sbjct: 970  NILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQK 1029

Query: 1132 VYAIIMLTKCVEQGRTKCEEYWP-SKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTS 1190
               I+MLT+C E+ R KC+ YWP +++   YGDITV M SE    +W  R F +      
Sbjct: 1030 SQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRIN--YAD 1087

Query: 1191 ESHPLRQFHFTSWPDHGVP--DTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGT 1248
            E   +  F++T+WPDHGVP  +  + ++ F ++VR    +S  + P+++HCSAGVGRTGT
Sbjct: 1088 EMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKS--KGPMIIHCSAGVGRTGT 1145

Query: 1249 FIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCV--LDIVRSQKDSK 1306
            FIA+DRL+  I +   VD+ G+V ++R +R  MVQTE+QY+F++QCV  + + + Q+   
Sbjct: 1146 FIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCI 1205

Query: 1307 VDLIYQNTT 1315
             D+IY+N +
Sbjct: 1206 SDVIYENVS 1214



 Score = 36.6 bits (83), Expect = 0.17
 Identities = 91/410 (22%), Positives = 158/410 (38%), Gaps = 68/410 (16%)

Query: 462 VTVVSTTEIGLAWSSHDAESFQMHIT-------QEGAGNSRVEI-----TTNQSIIIGGL 509
           V V+S+T   ++W+S   E++   I        Q+   + R+E        +   II  L
Sbjct: 441 VHVLSSTTALMSWTSSQ-ENYNSTIVSVVSLTCQKQKESQRLEKQYCTQVNSSKPIIENL 499

Query: 510 FPGTKYCFEI-VPKGPNGTEGASRTVCNRTVPSAVFDIHVVYVTTTEMWLDWKSP--DGA 566
            PG +Y   I + KGP      S  V    VP+ + D+ +  +  T + L W  P     
Sbjct: 500 VPGAQYQVVIYLRKGPL-IGPPSDPVTFAIVPTGIKDLMLYPLGPTAVVLSWTRPYLGVF 558

Query: 567 SEYVYHLVI--ESKHGSNHTSTYDKAITLQ--------GLIPGTLYNITISPEVDHVWGD 616
            +YV  +     +   S  T+ Y+ A T+          L+P   YN  ++      WGD
Sbjct: 559 RKYVVEMFYFNPATMTSEWTTYYEIAATVSLTASVRIANLLPAWYYNFRVTMVT---WGD 615

Query: 617 P------NSTAQY-TRPSNVSNIDVSTNTTAATLSWQNFDDASP-TYSYCL--LIEKAGN 666
           P      +ST  + T P       V    +   +SW   DD +  ++S  L  ++   G 
Sbjct: 616 PELSCCDSSTISFITAPVAPEITSVEYFNSLLYISWTYGDDTTDLSHSRMLHWMVVAEGK 675

Query: 667 SSNATQVVTDIGITDATVTELIPGSSYTVEIFAQVGDG-------IKSLEPGRKSFCTDP 719
                 V  ++      +  L PG  Y + + A    G       +  LEP        P
Sbjct: 676 KKIKKSVTRNVM---TAILSLPPGDIYNLSVTACTERGSNTSMLRLVKLEPA------PP 726

Query: 720 ASMASFDCEVVPKEPALVLKWTCPPGANAGFELEVSSGAWNNATHLESCSSENGTEYRTE 779
            S+ +    V   + ++ L W    G    FE+       +  T L+   + +   +   
Sbjct: 727 KSLFA----VNKTQTSVTLLWV-EEGVADFFEVFCQQVGSSQKTKLQEPVAVSS--HVVT 779

Query: 780 VTYLNFSTSYNISITTVSCGKMAAPTRNTCTTGITDPPPPDGSPNITSVS 829
           ++ L  +T+YN S+T+ S    + PT    +T +T+      +PN+  +S
Sbjct: 780 ISSLLPATAYNCSVTSFSHDSPSVPTFIAVSTMVTEM-----NPNVVVIS 824



 Score = 35.8 bits (81), Expect = 0.28
 Identities = 41/160 (25%), Positives = 67/160 (41%), Gaps = 18/160 (11%)

Query: 325 SRDTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQVFDVTAVNISATSLTL 384
           +R+    ++ L PG  YN +V +    G+      +  +        + AVN + TS+TL
Sbjct: 683 TRNVMTAILSLPPGDIYNLSVTACTERGSNTSMLRL-VKLEPAPPKSLFAVNKTQTSVTL 741

Query: 385 IWKVSDNESSSNYTYKIHVAGETDSSNLNVSEPRAV------IPGLRSSTFYNITVCPVL 438
           +W     E  +++ +++       S    + EP AV      I  L  +T YN +V    
Sbjct: 742 LWV---EEGVADF-FEVFCQQVGSSQKTKLQEPVAVSSHVVTISSLLPATAYNCSVTSFS 797

Query: 439 GDIEGTPGFLQVHT------PPVPVSDFRVTVVSTTEIGL 472
            D    P F+ V T      P V V    + ++ST  IGL
Sbjct: 798 HDSPSVPTFIAVSTMVTEMNPNVVVISV-LAILSTLLIGL 836



 Score = 34.3 bits (77), Expect = 0.82
 Identities = 69/291 (23%), Positives = 103/291 (35%), Gaps = 49/291 (16%)

Query: 119 PSPVFDIKAVSISPTNVILTWKSNDTAASEYKYVVKHKMENEKTI------------TVV 166
           P+ + D+    + PT V+L+W +        KYVV+    N  T+            TV 
Sbjct: 530 PTGIKDLMLYPLGPTAVVLSW-TRPYLGVFRKYVVEMFYFNPATMTSEWTTYYEIAATVS 588

Query: 167 HQPWCNITGLRPATSYVFSITPGIGNETWGDPRV-------IKVITEPIPVSDLRVALTG 219
                 I  L PA  Y F +T      TWGDP +       I  IT P+      V    
Sbjct: 589 LTASVRIANLLPAWYYNFRVT----MVTWGDPELSCCDSSTISFITAPVAPEITSVEYFN 644

Query: 220 VRKAALSWSNGNGTASCRVLLESIGSHEELTQDSRLQVNISGLKPGVQYNINPYLLQSNK 279
                +SW+ G+ T           SH  +     +      +K  V  N+   +L  + 
Sbjct: 645 -SLLYISWTYGDDTTDL--------SHSRMLHWMVVAEGKKKIKKSVTRNVMTAIL--SL 693

Query: 280 TKGDPLGTEGGLDASNTERSRAGSPTAPVHDESLVGPVDPSS--GQQSRDTEVLLVGLEP 337
             GD        + S T  +  GS T+ +    L  P  P S        T V L+ +E 
Sbjct: 694 PPGDI------YNLSVTACTERGSNTSMLRLVKL-EPAPPKSLFAVNKTQTSVTLLWVEE 746

Query: 338 GTRYNATVYSQAANGTE----GQPQAIEFRTNAI-QVFDVTAVNISATSLT 383
           G      V+ Q    ++     +P A+      I  +   TA N S TS +
Sbjct: 747 GVADFFEVFCQQVGSSQKTKLQEPVAVSSHVVTISSLLPATAYNCSVTSFS 797


>gi|18860894 protein tyrosine phosphatase, receptor type, D isoform 4
            precursor [Homo sapiens]
          Length = 1501

 Score =  274 bits (700), Expect = 5e-73
 Identities = 250/944 (26%), Positives = 412/944 (43%), Gaps = 103/944 (10%)

Query: 424  LRSSTFYNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDAESFQ 483
            +R S  Y       LG IE     + V   P P     VT  + T I L W S + E   
Sbjct: 294  VRQSANYTCVAMSTLGVIEAIAQ-ITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVS 352

Query: 484  MHITQEGAGNSR-----VEITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRT 538
             +I Q    NS      ++        + GL P + Y F +V     G    S  V  +T
Sbjct: 353  YYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQT 412

Query: 539  VP----SAVFDIHVVYVTTTEMWLDWKSPDGASEY-----VYHLVIESKHGSN---HTST 586
                  SA  D+    +++T + + WK P+  +       VY+ +  ++H +N   H   
Sbjct: 413  SEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVA 472

Query: 587  YDKAITLQGLIPGTLYNITISPEVDHVWGDPNSTAQYTRPSNVSNIDVS-----TNTTAA 641
              +  T+  L+P   Y++ +        G  +S  Q    + V    ++      + T+ 
Sbjct: 473  DSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSI 532

Query: 642  TLSWQNFDDASPTYSYCLLIEKAGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQV 701
             LSW      S T +   L+ K G      ++  + G T   +  L P S Y   + A+ 
Sbjct: 533  LLSWT--PPRSDTIANYELVYKDGEHGEEQRITIEPG-TSYRLQGLKPNSLYYFRLAARS 589

Query: 702  GDGIKSLEPGRKSFCTDPASMASFDCEVVPKEPALVLKWTCPPGANAGFELEVSSGAWNN 761
              G+ +      +         +F  + V K   L L W  P   N+    ++    +++
Sbjct: 590  PQGLGASTAEISARTMQSMFAKNFHVKAVMKTSVL-LSWEIPENYNSAMPFKI---LYDD 645

Query: 762  ATHLESCSSENGTEYRTEVTYLNFSTSYNISITT---VSCGKMAAPTRNTCTTGITDPPP 818
               +E     +G   +  +  L    SY+  +T     + G     T  T    +   P 
Sbjct: 646  GKMVEEV---DGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPA 702

Query: 819  PDGSPNITSVSHNSVKVKFSGFEASHGPIKAYAVIL-----TTGEAGHPSADVLKYTYED 873
              G  N+  +    + V+     A+   IK Y +I+     + G+   P     +   ++
Sbjct: 703  FIGKTNLDGM----ITVQLPEVPANEN-IKGYYIIIVPLKKSRGKFIKPWESPDEMELDE 757

Query: 874  FKKGASDTY--VTYLIRTEEKGRSQSLSEVLKYEIDVGNESTTLGYYNGKLEPLGSYRAC 931
              K  S     + Y    E K    +  +VL  E  +G++    G+ N +L+    Y   
Sbjct: 758  LLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFF 817

Query: 932  VAGFTNITFHPQNKGLIDGAESYV-SFSRYSD-AVSLPQDPGVIC----------GAVFG 979
            V              +++ AES + + S YSD  VS+  DP  I           G V  
Sbjct: 818  VLA------------VMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLA 865

Query: 980  CIFGALVIVTVGGFIFWRKKRKDAKNNEVSFSQIK------PKKSKLIRVENFEA----- 1028
             +F   +++ +   + +++KR ++ + + S    K      P     +R  NF+      
Sbjct: 866  VVFIICIVIAI---LLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMAS 922

Query: 1029 -----------YFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPY 1077
                       + ++ +A+ N  F++EYE +   G       + L  N+ KNRY NV+ Y
Sbjct: 923  HPPIPILELADHIERLKANDNLKFSQEYESID-PGQQFTWEHSNLEVNKPKNRYANVIAY 981

Query: 1078 DISRVKLS-VQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAII 1136
            D SRV LS ++     DY+NANY+ GY  +  +IATQG LP T  DFWRM+WE+    ++
Sbjct: 982  DHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVV 1041

Query: 1137 MLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLR 1196
            M+TK  E+ R KC++YWPS+  + +G + V +   + L  + +R F +    +SE   +R
Sbjct: 1042 MMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVR 1101

Query: 1197 QFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPES-PILVHCSAGVGRTGTFIAIDRL 1255
            QF FT+WPDHGVP+     + F   +R     +PP++ P++VHCSAGVGRTG FI ID +
Sbjct: 1102 QFQFTAWPDHGVPEHPTPFLAF---LRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAM 1158

Query: 1256 IYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIV 1299
            + +I++E TVD+YG V  +R  R  MVQTEDQY+F++  +L+ V
Sbjct: 1159 LERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV 1202



 Score =  209 bits (533), Expect = 1e-53
 Identities = 111/287 (38%), Positives = 168/287 (58%), Gaps = 6/287 (2%)

Query: 1021 IRVENFEAYFKK----QQADSNCGFAEEYEDLKLVGISQPKY-AAELAENRGKNRYNNVL 1075
            +   N  AY +K    +  ++  G   E++ L        ++ +A L  N+ KNR  N++
Sbjct: 1209 VPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIM 1268

Query: 1076 PYDISRVKLS-VQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYA 1134
            PY+ +RV L  ++     DYINA+++ GY  +K +IATQGPL  T +DFWRM+WE N   
Sbjct: 1269 PYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTI 1328

Query: 1135 IIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHP 1194
            ++MLTK  E GR KC +YWP++++  Y    V   +E  +P++ +R+F V + +  +S  
Sbjct: 1329 VVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRT 1388

Query: 1195 LRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDR 1254
            +RQF FT WP+ GVP + +  I+F   V    +Q   + PI VHCSAGVGRTG FI +  
Sbjct: 1389 VRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSI 1448

Query: 1255 LIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRS 1301
            ++ ++  E  VD++  V  LR  RP MVQTEDQY F  +  L+ + S
Sbjct: 1449 VLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS 1495



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 70/306 (22%), Positives = 115/306 (37%), Gaps = 32/306 (10%)

Query: 378 SATSLTLIWKVSDNESSSNY--TYKIHVAGETDSSNLNVSEPRAVIPGLRSSTFYNITVC 435
           +ATS+TL W   + E  S Y   +K   + E       V+  R  + GL   + Y   V 
Sbjct: 335 TATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVV 394

Query: 436 PVLGDIEGTPG--FLQVHTPPVPVS---DFRVTVVSTTEIGLAWSSHDAES--------- 481
            V     G P    L   +   P S   D +  ++S+T I + W   +  +         
Sbjct: 395 AVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVY 454

Query: 482 FQMHITQEGAGNSRVEITTNQSIIIGGLFPGTKY-----CFEIVPKGPNGTEGASRTVCN 536
           + M  TQ      +  +  +Q   IG L P   Y      F  +  GP  ++   + +  
Sbjct: 455 YTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSD--IQVITQ 512

Query: 537 RTVPSAVFDIHVVYVTTTEMWLDWKSPDGASEYVYHLVI-ESKHGSNHTSTYDKAIT--L 593
             VP    +      + T + L W  P   +   Y LV  + +HG     T +   +  L
Sbjct: 513 TGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRL 572

Query: 594 QGLIPGTLYNITISPEVDHVWGDPNS--TAQYTRPSNVSNIDV-STNTTAATLSW---QN 647
           QGL P +LY   ++       G   +  +A+  +     N  V +   T+  LSW   +N
Sbjct: 573 QGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSMFAKNFHVKAVMKTSVLLSWEIPEN 632

Query: 648 FDDASP 653
           ++ A P
Sbjct: 633 YNSAMP 638



 Score = 45.8 bits (107), Expect = 3e-04
 Identities = 55/260 (21%), Positives = 102/260 (39%), Gaps = 27/260 (10%)

Query: 328 TEVLLVGLEPGTRYNATVYS--QAANGTEGQPQAIEFRTNAIQVF--DVTAVNISATSLT 383
           T   + GL P + Y   V +      G   +P   +    A      DV A  +S+T++ 
Sbjct: 376 TRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTIL 435

Query: 384 LIWKVSDNESSSNYTYKIHVAGETDSS-----NLNVSEPRAVIPG---------LRSSTF 429
           + WK  +  +     Y+++   +           NV++ +    G         ++   F
Sbjct: 436 VQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAF 495

Query: 430 YNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDAESFQ----MH 485
            +I   P+  DI+      Q   P  P++ F+    S T I L+W+   +++      ++
Sbjct: 496 TSIGDGPLSSDIQV---ITQTGVPGQPLN-FKAEPESETSILLSWTPPRSDTIANYELVY 551

Query: 486 ITQEGAGNSRVEITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTVPSA-VF 544
              E     R+ I    S  + GL P + Y F +  + P G   ++  +  RT+ S    
Sbjct: 552 KDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSMFAK 611

Query: 545 DIHVVYVTTTEMWLDWKSPD 564
           + HV  V  T + L W+ P+
Sbjct: 612 NFHVKAVMKTSVLLSWEIPE 631


>gi|104487002 protein tyrosine phosphatase, receptor type, D isoform 5
            precursor [Homo sapiens]
          Length = 1502

 Score =  269 bits (688), Expect = 1e-71
 Identities = 252/945 (26%), Positives = 407/945 (43%), Gaps = 101/945 (10%)

Query: 424  LRSSTFYNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDAESFQ 483
            +R S  Y       LG IE     + V   P P     VT  + T I L W S + E   
Sbjct: 291  VRQSANYTCVAMSTLGVIEAIAQ-ITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVS 349

Query: 484  MHITQEGAGNSR-----VEITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRT 538
             +I Q    NS      ++        + GL P + Y F +V     G    S  V  +T
Sbjct: 350  YYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQT 409

Query: 539  VP----SAVFDIHVVYVTTTEMWLDWKSPDGASEY-----VYHLVIESKHGSN---HTST 586
                  SA  D+    +++T + + WK P+  +       VY+ +  ++H +N   H   
Sbjct: 410  SEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVA 469

Query: 587  YDKAITLQGLIPGTLYNITISPEVDHVWGDPNSTAQYTRPSNVSNIDVS-----TNTTAA 641
              +  T+  L+P   Y++ +        G  +S  Q    + V    ++      + T+ 
Sbjct: 470  DSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSI 529

Query: 642  TLSWQNFDDASPTYSYCLLIEKAGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQV 701
             LSW      S T +   L+ K G      ++  + G T   +  L P S Y   + A+ 
Sbjct: 530  LLSWT--PPRSDTIANYELVYKDGEHGEEQRITIEPG-TSYRLQGLKPNSLYYFRLAARS 586

Query: 702  GDGIKSLEPGRKSFCTDPASMASFDCEVVPKEPALVLKWTCPPGANAGFELEVSSGAWNN 761
              G+ +      +         +F  + V K   L L W  P   N+    ++    +++
Sbjct: 587  PQGLGASTAEISARTMQSMFAKNFHVKAVMKTSVL-LSWEIPENYNSAMPFKI---LYDD 642

Query: 762  ATHLESCSSENGTEYRTEVTYLNFSTSYNISITT---VSCGKMAAPTRNTCTTGITDPPP 818
               +E     +G   +  +  L    SY+  +T     + G     T  T    +   P 
Sbjct: 643  GKMVEEV---DGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPA 699

Query: 819  PDGSPNITSVSHNSVKVKFSGFEASHGPIKAYAVIL-----TTGEAGHPSADVLKYTYED 873
              G  N+  +    + V+     A+   IK Y +I+     + G+   P     +   ++
Sbjct: 700  FIGKTNLDGM----ITVQLPEVPANEN-IKGYYIIIVPLKKSRGKFIKPWESPDEMELDE 754

Query: 874  FKKGASDTY--VTYLIRTEEKGRSQSLSEVLKYEIDVGNESTTLGYYNGKLEPLGSYRAC 931
              K  S     + Y    E K    +  +VL  E  +G++    G+ N +L+    Y   
Sbjct: 755  LLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFF 814

Query: 932  VAGFTNITFHPQNKGLIDGAESYV-SFSRYSD-AVSLPQDPGVICGA------VFGCIFG 983
            V              +++ AES + + S YSD  VS+  DP  I         V G +  
Sbjct: 815  VLA------------VMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLA 862

Query: 984  ALVIVTVGGFIFWRKKRKDAKNNEVSFSQIKPKKSKLI-----------RVENFEA---- 1028
             + I+ +   I   K + D K  E    +     +K I           R  NF+     
Sbjct: 863  VVFIICIVIAILLYKSKPDRKRAESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMA 922

Query: 1029 ------------YFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLP 1076
                        + ++ +A+ N  F++EYE +   G       + L  N+ KNRY NV+ 
Sbjct: 923  SHPPIPILELADHIERLKANDNLKFSQEYESID-PGQQFTWEHSNLEVNKPKNRYANVIA 981

Query: 1077 YDISRVKLS-VQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAI 1135
            YD SRV LS ++     DY+NANY+ GY  +  +IATQG LP T  DFWRM+WE+    +
Sbjct: 982  YDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATV 1041

Query: 1136 IMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPL 1195
            +M+TK  E+ R KC++YWPS+  + +G + V +   + L  + +R F +    +SE   +
Sbjct: 1042 VMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREV 1101

Query: 1196 RQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPES-PILVHCSAGVGRTGTFIAIDR 1254
            RQF FT+WPDHGVP+     + F   +R     +PP++ P++VHCSAGVGRTG FI ID 
Sbjct: 1102 RQFQFTAWPDHGVPEHPTPFLAF---LRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDA 1158

Query: 1255 LIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIV 1299
            ++ +I++E TVD+YG V  +R  R  MVQTEDQY+F++  +L+ V
Sbjct: 1159 MLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV 1203



 Score =  209 bits (533), Expect = 1e-53
 Identities = 111/287 (38%), Positives = 168/287 (58%), Gaps = 6/287 (2%)

Query: 1021 IRVENFEAYFKK----QQADSNCGFAEEYEDLKLVGISQPKY-AAELAENRGKNRYNNVL 1075
            +   N  AY +K    +  ++  G   E++ L        ++ +A L  N+ KNR  N++
Sbjct: 1210 VPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIM 1269

Query: 1076 PYDISRVKLS-VQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYA 1134
            PY+ +RV L  ++     DYINA+++ GY  +K +IATQGPL  T +DFWRM+WE N   
Sbjct: 1270 PYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTI 1329

Query: 1135 IIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHP 1194
            ++MLTK  E GR KC +YWP++++  Y    V   +E  +P++ +R+F V + +  +S  
Sbjct: 1330 VVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRT 1389

Query: 1195 LRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDR 1254
            +RQF FT WP+ GVP + +  I+F   V    +Q   + PI VHCSAGVGRTG FI +  
Sbjct: 1390 VRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSI 1449

Query: 1255 LIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRS 1301
            ++ ++  E  VD++  V  LR  RP MVQTEDQY F  +  L+ + S
Sbjct: 1450 VLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS 1496



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 70/306 (22%), Positives = 115/306 (37%), Gaps = 32/306 (10%)

Query: 378 SATSLTLIWKVSDNESSSNY--TYKIHVAGETDSSNLNVSEPRAVIPGLRSSTFYNITVC 435
           +ATS+TL W   + E  S Y   +K   + E       V+  R  + GL   + Y   V 
Sbjct: 332 TATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVV 391

Query: 436 PVLGDIEGTPG--FLQVHTPPVPVS---DFRVTVVSTTEIGLAWSSHDAES--------- 481
            V     G P    L   +   P S   D +  ++S+T I + W   +  +         
Sbjct: 392 AVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVY 451

Query: 482 FQMHITQEGAGNSRVEITTNQSIIIGGLFPGTKY-----CFEIVPKGPNGTEGASRTVCN 536
           + M  TQ      +  +  +Q   IG L P   Y      F  +  GP  ++   + +  
Sbjct: 452 YTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSD--IQVITQ 509

Query: 537 RTVPSAVFDIHVVYVTTTEMWLDWKSPDGASEYVYHLVI-ESKHGSNHTSTYDKAIT--L 593
             VP    +      + T + L W  P   +   Y LV  + +HG     T +   +  L
Sbjct: 510 TGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRL 569

Query: 594 QGLIPGTLYNITISPEVDHVWGDPNS--TAQYTRPSNVSNIDV-STNTTAATLSW---QN 647
           QGL P +LY   ++       G   +  +A+  +     N  V +   T+  LSW   +N
Sbjct: 570 QGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSMFAKNFHVKAVMKTSVLLSWEIPEN 629

Query: 648 FDDASP 653
           ++ A P
Sbjct: 630 YNSAMP 635



 Score = 45.8 bits (107), Expect = 3e-04
 Identities = 55/260 (21%), Positives = 102/260 (39%), Gaps = 27/260 (10%)

Query: 328 TEVLLVGLEPGTRYNATVYS--QAANGTEGQPQAIEFRTNAIQVF--DVTAVNISATSLT 383
           T   + GL P + Y   V +      G   +P   +    A      DV A  +S+T++ 
Sbjct: 373 TRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTIL 432

Query: 384 LIWKVSDNESSSNYTYKIHVAGETDSS-----NLNVSEPRAVIPG---------LRSSTF 429
           + WK  +  +     Y+++   +           NV++ +    G         ++   F
Sbjct: 433 VQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAF 492

Query: 430 YNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDAESFQ----MH 485
            +I   P+  DI+      Q   P  P++ F+    S T I L+W+   +++      ++
Sbjct: 493 TSIGDGPLSSDIQV---ITQTGVPGQPLN-FKAEPESETSILLSWTPPRSDTIANYELVY 548

Query: 486 ITQEGAGNSRVEITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTVPSA-VF 544
              E     R+ I    S  + GL P + Y F +  + P G   ++  +  RT+ S    
Sbjct: 549 KDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSMFAK 608

Query: 545 DIHVVYVTTTEMWLDWKSPD 564
           + HV  V  T + L W+ P+
Sbjct: 609 NFHVKAVMKTSVLLSWEIPE 628


>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform 3
            precursor [Homo sapiens]
          Length = 1903

 Score =  269 bits (688), Expect = 1e-71
 Identities = 324/1330 (24%), Positives = 544/1330 (40%), Gaps = 197/1330 (14%)

Query: 119  PSPVFDIKAVSISPTNVILTWKSNDTAASEYKYVVKHKMENE----KTITVVHQPWCNIT 174
            P P         + T++ LTW S +     Y Y+++HK +N     K I  V     ++ 
Sbjct: 323  PKPPGTPVVTESTATSITLTWDSGNPEPVSY-YIIQHKPKNSEELYKEIDGVATTRYSVA 381

Query: 175  GLRPATSYVFSITPGIGNETWGDPR--VIKVITEPIPVS---DLRVALTGVRKAALSWSN 229
            GL P + Y F +   + N   G P   V+   +E  P S   D++  +       + W  
Sbjct: 382  GLSPYSDYEFRVV-AVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKE 440

Query: 230  G---NGTASCRVLLESIGSHEELTQDSRLQVNISGLKPGVQYNINPYLLQSNKTKGDPLG 286
                NG      +  ++   + +  ++ ++ N++  +     N+ P    S K       
Sbjct: 441  PEEPNGQIQGYRVYYTMDPTQHV--NNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSI 498

Query: 287  TEGGLDASNTERSRAGSPTAPVHDES--------LVGPVDPSS---------------GQ 323
             +G L +     ++ G P  P++ ++        L+    P S               G+
Sbjct: 499  GDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGE 558

Query: 324  QSR-----DTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQVF----DVTA 374
            + R      T   L GL+P + Y   + +++  G       I  RT   +      D++ 
Sbjct: 559  EQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISC 618

Query: 375  VNISATSLTLIWKVSDNESSSN----YTYKIH-VAGETDSSNLNVSEP----RAVIPGLR 425
             + S+TS+ + W+    E  +     Y+ K   V GE D  +  +  P    + ++  L 
Sbjct: 619  TSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLE 678

Query: 426  SSTFYNITVCPVLGDIEGTPGFLQV------HTPPVPVSDFRVTVVSTTEIGLAWSSH-- 477
              T Y ITV     D+   P  L V        P  P     V  V++T + ++W S   
Sbjct: 679  KWTEYRITVTAHT-DVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVP 737

Query: 478  -----DAESFQMHITQEGAGNSR-------VEITTNQSIIIGGLFPGTKYCFEIVPKGPN 525
                     +Q+H  +   G  +       V +   Q +II GL P T Y   +      
Sbjct: 738  NKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQDMIISGLQPETSYSLTVTAYTTK 797

Query: 526  GTEGASRTVCNRTVPSAVFDIHVVYVTTTEM---WLDWKSPDGASEYV--YHLVIESKHG 580
            G    S+     T  +      +V +  T+M    + W  P      +  Y L    K  
Sbjct: 798  GDGARSKPKLVSTTGAVPGKPRLV-INHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDM 856

Query: 581  SNHT----STYDKAITLQGLIPGTLYNITISPEVDHVWGDPNSTAQYTRPSNV-----SN 631
               T    S  +   T   +  G  Y   +S      +G+     + + P  V      N
Sbjct: 857  EPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGE-EMVKEISIPEEVPTGFPQN 915

Query: 632  I-DVSTNTTAATLSWQNFDDASPTYSYCLLIEKAGNSSNATQVVTDIGI----------- 679
            +    T +T+  LSWQ            +L E+ G  +  T +  DI I           
Sbjct: 916  LHSEGTTSTSVQLSWQP----------PVLAERNGIITKYTLLYRDINIPLLPMEQLIVP 965

Query: 680  --TDATVTELIPGSSYTVEIFAQVGDGIKSLEPGR--KSFCTDPASMASFDCEVVPKEPA 735
              T  T+T L P ++Y V++ A    G     P    ++   D     +F  + V K   
Sbjct: 966  ADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSV 1025

Query: 736  LVLKWTCPPGANAGFELEVSSGAWNNATHLESCSSENGTEYRTEVTYLNFSTSYNISITT 795
            L L W  P   N+    ++    +++   +E     +G   +  +  L    SY+  +T 
Sbjct: 1026 L-LSWEIPENYNSAMPFKI---LYDDGKMVEEV---DGRATQKLIVNLKPEKSYSFVLTN 1078

Query: 796  ---VSCGKMAAPTRNTCTTGITDPPPPDGSPNITSVSHNSVKVKFSGFEASHGPIKAYAV 852
                + G     T  T    +   P   G  N+  +    + V+     A+   IK Y +
Sbjct: 1079 RGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGM----ITVQLPEVPANEN-IKGYYI 1133

Query: 853  IL-----TTGEAGHPSADVLKYTYEDFKKGASDTY--VTYLIRTEEKGRSQSLSEVLKYE 905
            I+     + G+   P     +   ++  K  S     + Y    E K    +  +VL  E
Sbjct: 1134 IIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLPTE 1193

Query: 906  IDVGNESTTLGYYNGKLEPLGSYRACVAGFTNITFHPQNKGLIDGAESYV-SFSRYSD-A 963
              +G++    G+ N +L+    Y   V              +++ AES + + S YSD  
Sbjct: 1194 FTLGDDKHYGGFTNKQLQSGQEYVFFVLA------------VMEHAESKMYATSPYSDPV 1241

Query: 964  VSLPQDPGVIC----------GAVFGCIFGALVIVTVGGFIFWRKKRKDAKNNEVSFSQI 1013
            VS+  DP  I           G V   +F   +++ +   + +++KR ++ + + S    
Sbjct: 1242 VSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAI---LLYKRKRAESDSRKSSIPNN 1298

Query: 1014 K------PKKSKLIRVENFEA----------------YFKKQQADSNCGFAEEYEDLKLV 1051
            K      P     +R  NF+                 + ++ +A+ N  F++EYE +   
Sbjct: 1299 KEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESID-P 1357

Query: 1052 GISQPKYAAELAENRGKNRYNNVLPYDISRVKLS-VQTHSTDDYINANYMPGYHSKKDFI 1110
            G       + L  N+ KNRY NV+ YD SRV LS ++     DY+NANY+ GY  +  +I
Sbjct: 1358 GQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYI 1417

Query: 1111 ATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTS 1170
            ATQG LP T  DFWRM+WE+    ++M+TK  E+ R KC++YWPS+  + +G + V +  
Sbjct: 1418 ATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLD 1477

Query: 1171 EIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSP 1230
             + L  + +R F +    +SE   +RQF FT+WPDHGVP+     + F   +R     +P
Sbjct: 1478 TVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAF---LRRVKTCNP 1534

Query: 1231 PES-PILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYV 1289
            P++ P++VHCSAGVGRTG FI ID ++ +I++E TVD+YG V  +R  R  MVQTEDQY+
Sbjct: 1535 PDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYI 1594

Query: 1290 FLNQCVLDIV 1299
            F++  +L+ V
Sbjct: 1595 FIHDALLEAV 1604



 Score =  209 bits (533), Expect = 1e-53
 Identities = 111/287 (38%), Positives = 168/287 (58%), Gaps = 6/287 (2%)

Query: 1021 IRVENFEAYFKK----QQADSNCGFAEEYEDLKLVGISQPKY-AAELAENRGKNRYNNVL 1075
            +   N  AY +K    +  ++  G   E++ L        ++ +A L  N+ KNR  N++
Sbjct: 1611 VPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIM 1670

Query: 1076 PYDISRVKLS-VQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYA 1134
            PY+ +RV L  ++     DYINA+++ GY  +K +IATQGPL  T +DFWRM+WE N   
Sbjct: 1671 PYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTI 1730

Query: 1135 IIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHP 1194
            ++MLTK  E GR KC +YWP++++  Y    V   +E  +P++ +R+F V + +  +S  
Sbjct: 1731 VVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRT 1790

Query: 1195 LRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDR 1254
            +RQF FT WP+ GVP + +  I+F   V    +Q   + PI VHCSAGVGRTG FI +  
Sbjct: 1791 VRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSI 1850

Query: 1255 LIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRS 1301
            ++ ++  E  VD++  V  LR  RP MVQTEDQY F  +  L+ + S
Sbjct: 1851 VLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS 1897



 Score = 65.9 bits (159), Expect = 3e-10
 Identities = 103/472 (21%), Positives = 173/472 (36%), Gaps = 39/472 (8%)

Query: 424 LRSSTFYNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDAESFQ 483
           +R S  Y       LG IE     + V   P P     VT  + T I L W S + E   
Sbjct: 294 VRQSANYTCVAMSTLGVIEAIAQ-ITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVS 352

Query: 484 MHITQEGAGNS-----RVEITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRT 538
            +I Q    NS      ++        + GL P + Y F +V     G    S  V  +T
Sbjct: 353 YYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQT 412

Query: 539 ----VPSAVFDIHVVYVTTTEMWLDWKSPDGASEY-----VYHLVIESKHGSN---HTST 586
                 SA  D+    +++T + + WK P+  +       VY+ +  ++H +N   H   
Sbjct: 413 SEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVA 472

Query: 587 YDKAITLQGLIPGTLYNITISPEVDHVWGDPNSTAQYTRPSNVSNIDVS-----TNTTAA 641
             +  T+  L+P   Y++ +        G  +S  Q    + V    ++      + T+ 
Sbjct: 473 DSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSI 532

Query: 642 TLSWQNFDDASPTYSYCLLIEKAGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQ- 700
            LSW      S T +   L+ K G      ++  + G T   +  L P S Y   + A+ 
Sbjct: 533 LLSWT--PPRSDTIANYELVYKDGEHGEEQRITIEPG-TSYRLQGLKPNSLYYFRLAARS 589

Query: 701 -VGDGIKSLEPGRKSFCTDPASMASFDCEVVPKEPALVLKWTCPP-----GANAGFELEV 754
             G G  + E   ++  + P++         P   ++++ W  PP     G    + ++ 
Sbjct: 590 PQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKY 649

Query: 755 SS-GAWNNATHLESCSSENGTEYRTEVTYLNFSTSYNISITT-VSCGKMAAPTRNTCTTG 812
           ++    ++  H       + T+Y  E   L   T Y I++T     G           T 
Sbjct: 650 TAVDGEDDKPHEILGIPSDTTKYLLE--QLEKWTEYRITVTAHTDVGPGPESLSVLIRTN 707

Query: 813 ITDPPPPDGSPNITSVSHNSVKVKFSG--FEASHGPIKAYAVILTTGEAGHP 862
              P  P     + +V+  SVKV +        HG I+ Y V     E G P
Sbjct: 708 EDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEP 759


>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
            precursor [Homo sapiens]
          Length = 1912

 Score =  266 bits (681), Expect = 8e-71
 Identities = 324/1339 (24%), Positives = 544/1339 (40%), Gaps = 206/1339 (15%)

Query: 119  PSPVFDIKAVSISPTNVILTWKSNDTAASEYKYVVKHKMENE----KTITVVHQPWCNIT 174
            P P         + T++ LTW S +     Y Y+++HK +N     K I  V     ++ 
Sbjct: 323  PKPPGTPVVTESTATSITLTWDSGNPEPVSY-YIIQHKPKNSEELYKEIDGVATTRYSVA 381

Query: 175  GLRPATSYVFSITPGIGNETWGDPR--VIKVITEPIPVS---DLRVALTGVRKAALSWSN 229
            GL P + Y F +   + N   G P   V+   +E  P S   D++  +       + W  
Sbjct: 382  GLSPYSDYEFRVV-AVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKE 440

Query: 230  G---NGTASCRVLLESIGSHEELTQDSRLQVNISGLKPGVQYNINPYLLQSNKTKGDPLG 286
                NG      +  ++   + +  ++ ++ N++  +     N+ P    S K       
Sbjct: 441  PEEPNGQIQGYRVYYTMDPTQHV--NNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSI 498

Query: 287  TEGGLDASNTERSRAGSPTAPVHDES--------LVGPVDPSS---------------GQ 323
             +G L +     ++ G P  P++ ++        L+    P S               G+
Sbjct: 499  GDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGE 558

Query: 324  QSR-----DTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQVF----DVTA 374
            + R      T   L GL+P + Y   + +++  G       I  RT   +      D++ 
Sbjct: 559  EQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISC 618

Query: 375  VNISATSLTLIWKVSDNESSSN----YTYKIH-VAGETDSSNLNVSEP----RAVIPGLR 425
             + S+TS+ + W+    E  +     Y+ K   V GE D  +  +  P    + ++  L 
Sbjct: 619  TSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLE 678

Query: 426  SSTFYNITVCPVLGDIEGTPGFLQV------HTPPVPVSDFRVTVVSTTEIGLAWSSH-- 477
              T Y ITV     D+   P  L V        P  P     V  V++T + ++W S   
Sbjct: 679  KWTEYRITVTAHT-DVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVP 737

Query: 478  -----DAESFQMHITQEGAGNSR----------------VEITTNQSIIIGGLFPGTKYC 516
                     +Q+H  +   G  +                 + TT   +II GL P T Y 
Sbjct: 738  NKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYS 797

Query: 517  FEIVPKGPNGTEGASRTVCNRTVPSAVFDIHVVYVTTTEM---WLDWKSPDGASEYV--Y 571
              +      G    S+     T  +      +V +  T+M    + W  P      +  Y
Sbjct: 798  LTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLV-INHTQMNTALIQWHPPVDTFGPLQGY 856

Query: 572  HLVIESKHGSNHT----STYDKAITLQGLIPGTLYNITISPEVDHVWGDPNSTAQYTRPS 627
             L    K     T    S  +   T   +  G  Y   +S      +G+     + + P 
Sbjct: 857  RLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGE-EMVKEISIPE 915

Query: 628  NV-----SNI-DVSTNTTAATLSWQNFDDASPTYSYCLLIEKAGNSSNATQVVTDIGI-- 679
             V      N+    T +T+  LSWQ            +L E+ G  +  T +  DI I  
Sbjct: 916  EVPTGFPQNLHSEGTTSTSVQLSWQP----------PVLAERNGIITKYTLLYRDINIPL 965

Query: 680  -----------TDATVTELIPGSSYTVEIFAQVGDGIKSLEPGR--KSFCTDPASMASFD 726
                       T  T+T L P ++Y V++ A    G     P    ++   D     +F 
Sbjct: 966  LPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFH 1025

Query: 727  CEVVPKEPALVLKWTCPPGANAGFELEVSSGAWNNATHLESCSSENGTEYRTEVTYLNFS 786
             + V K   L L W  P   N+    ++    +++   +E     +G   +  +  L   
Sbjct: 1026 VKAVMKTSVL-LSWEIPENYNSAMPFKI---LYDDGKMVEEV---DGRATQKLIVNLKPE 1078

Query: 787  TSYNISITT---VSCGKMAAPTRNTCTTGITDPPPPDGSPNITSVSHNSVKVKFSGFEAS 843
             SY+  +T     + G     T  T    +   P   G  N+  +    + V+     A+
Sbjct: 1079 KSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGM----ITVQLPEVPAN 1134

Query: 844  HGPIKAYAVIL-----TTGEAGHPSADVLKYTYEDFKKGASDTY--VTYLIRTEEKGRSQ 896
               IK Y +I+     + G+   P     +   ++  K  S     + Y    E K    
Sbjct: 1135 EN-IKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIA 1193

Query: 897  SLSEVLKYEIDVGNESTTLGYYNGKLEPLGSYRACVAGFTNITFHPQNKGLIDGAESYV- 955
            +  +VL  E  +G++    G+ N +L+    Y   V              +++ AES + 
Sbjct: 1194 AHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLA------------VMEHAESKMY 1241

Query: 956  SFSRYSD-AVSLPQDPGVIC----------GAVFGCIFGALVIVTVGGFIFWRKKRKDAK 1004
            + S YSD  VS+  DP  I           G V   +F   +++ +   + +++KR ++ 
Sbjct: 1242 ATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAI---LLYKRKRAESD 1298

Query: 1005 NNEVSFSQIK------PKKSKLIRVENFEA----------------YFKKQQADSNCGFA 1042
            + + S    K      P     +R  NF+                 + ++ +A+ N  F+
Sbjct: 1299 SRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFS 1358

Query: 1043 EEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLS-VQTHSTDDYINANYMP 1101
            +EYE +   G       + L  N+ KNRY NV+ YD SRV LS ++     DY+NANY+ 
Sbjct: 1359 QEYESID-PGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYID 1417

Query: 1102 GYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDY 1161
            GY  +  +IATQG LP T  DFWRM+WE+    ++M+TK  E+ R KC++YWPS+  + +
Sbjct: 1418 GYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETH 1477

Query: 1162 GDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYL 1221
            G + V +   + L  + +R F +    +SE   +RQF FT+WPDHGVP+     + F   
Sbjct: 1478 GLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAF--- 1534

Query: 1222 VRDYMKQSPPES-PILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPL 1280
            +R     +PP++ P++VHCSAGVGRTG FI ID ++ +I++E TVD+YG V  +R  R  
Sbjct: 1535 LRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNY 1594

Query: 1281 MVQTEDQYVFLNQCVLDIV 1299
            MVQTEDQY+F++  +L+ V
Sbjct: 1595 MVQTEDQYIFIHDALLEAV 1613



 Score =  209 bits (533), Expect = 1e-53
 Identities = 111/287 (38%), Positives = 168/287 (58%), Gaps = 6/287 (2%)

Query: 1021 IRVENFEAYFKK----QQADSNCGFAEEYEDLKLVGISQPKY-AAELAENRGKNRYNNVL 1075
            +   N  AY +K    +  ++  G   E++ L        ++ +A L  N+ KNR  N++
Sbjct: 1620 VPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIM 1679

Query: 1076 PYDISRVKLS-VQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYA 1134
            PY+ +RV L  ++     DYINA+++ GY  +K +IATQGPL  T +DFWRM+WE N   
Sbjct: 1680 PYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTI 1739

Query: 1135 IIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHP 1194
            ++MLTK  E GR KC +YWP++++  Y    V   +E  +P++ +R+F V + +  +S  
Sbjct: 1740 VVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRT 1799

Query: 1195 LRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDR 1254
            +RQF FT WP+ GVP + +  I+F   V    +Q   + PI VHCSAGVGRTG FI +  
Sbjct: 1800 VRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSI 1859

Query: 1255 LIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRS 1301
            ++ ++  E  VD++  V  LR  RP MVQTEDQY F  +  L+ + S
Sbjct: 1860 VLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS 1906



 Score = 65.9 bits (159), Expect = 3e-10
 Identities = 103/472 (21%), Positives = 173/472 (36%), Gaps = 39/472 (8%)

Query: 424 LRSSTFYNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDAESFQ 483
           +R S  Y       LG IE     + V   P P     VT  + T I L W S + E   
Sbjct: 294 VRQSANYTCVAMSTLGVIEAIAQ-ITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVS 352

Query: 484 MHITQEGAGNS-----RVEITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRT 538
            +I Q    NS      ++        + GL P + Y F +V     G    S  V  +T
Sbjct: 353 YYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQT 412

Query: 539 ----VPSAVFDIHVVYVTTTEMWLDWKSPDGASEY-----VYHLVIESKHGSN---HTST 586
                 SA  D+    +++T + + WK P+  +       VY+ +  ++H +N   H   
Sbjct: 413 SEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVA 472

Query: 587 YDKAITLQGLIPGTLYNITISPEVDHVWGDPNSTAQYTRPSNVSNIDVS-----TNTTAA 641
             +  T+  L+P   Y++ +        G  +S  Q    + V    ++      + T+ 
Sbjct: 473 DSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSI 532

Query: 642 TLSWQNFDDASPTYSYCLLIEKAGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQ- 700
            LSW      S T +   L+ K G      ++  + G T   +  L P S Y   + A+ 
Sbjct: 533 LLSWT--PPRSDTIANYELVYKDGEHGEEQRITIEPG-TSYRLQGLKPNSLYYFRLAARS 589

Query: 701 -VGDGIKSLEPGRKSFCTDPASMASFDCEVVPKEPALVLKWTCPP-----GANAGFELEV 754
             G G  + E   ++  + P++         P   ++++ W  PP     G    + ++ 
Sbjct: 590 PQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKY 649

Query: 755 SS-GAWNNATHLESCSSENGTEYRTEVTYLNFSTSYNISITT-VSCGKMAAPTRNTCTTG 812
           ++    ++  H       + T+Y  E   L   T Y I++T     G           T 
Sbjct: 650 TAVDGEDDKPHEILGIPSDTTKYLLE--QLEKWTEYRITVTAHTDVGPGPESLSVLIRTN 707

Query: 813 ITDPPPPDGSPNITSVSHNSVKVKFSG--FEASHGPIKAYAVILTTGEAGHP 862
              P  P     + +V+  SVKV +        HG I+ Y V     E G P
Sbjct: 708 EDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEP 759


>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform 2
            precursor [Homo sapiens]
          Length = 1899

 Score =  266 bits (681), Expect = 8e-71
 Identities = 324/1339 (24%), Positives = 544/1339 (40%), Gaps = 206/1339 (15%)

Query: 119  PSPVFDIKAVSISPTNVILTWKSNDTAASEYKYVVKHKMENE----KTITVVHQPWCNIT 174
            P P         + T++ LTW S +     Y Y+++HK +N     K I  V     ++ 
Sbjct: 310  PKPPGTPVVTESTATSITLTWDSGNPEPVSY-YIIQHKPKNSEELYKEIDGVATTRYSVA 368

Query: 175  GLRPATSYVFSITPGIGNETWGDPR--VIKVITEPIPVS---DLRVALTGVRKAALSWSN 229
            GL P + Y F +   + N   G P   V+   +E  P S   D++  +       + W  
Sbjct: 369  GLSPYSDYEFRVV-AVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKE 427

Query: 230  G---NGTASCRVLLESIGSHEELTQDSRLQVNISGLKPGVQYNINPYLLQSNKTKGDPLG 286
                NG      +  ++   + +  ++ ++ N++  +     N+ P    S K       
Sbjct: 428  PEEPNGQIQGYRVYYTMDPTQHV--NNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSI 485

Query: 287  TEGGLDASNTERSRAGSPTAPVHDES--------LVGPVDPSS---------------GQ 323
             +G L +     ++ G P  P++ ++        L+    P S               G+
Sbjct: 486  GDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGE 545

Query: 324  QSR-----DTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQVF----DVTA 374
            + R      T   L GL+P + Y   + +++  G       I  RT   +      D++ 
Sbjct: 546  EQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISC 605

Query: 375  VNISATSLTLIWKVSDNESSSN----YTYKIH-VAGETDSSNLNVSEP----RAVIPGLR 425
             + S+TS+ + W+    E  +     Y+ K   V GE D  +  +  P    + ++  L 
Sbjct: 606  TSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLE 665

Query: 426  SSTFYNITVCPVLGDIEGTPGFLQV------HTPPVPVSDFRVTVVSTTEIGLAWSSH-- 477
              T Y ITV     D+   P  L V        P  P     V  V++T + ++W S   
Sbjct: 666  KWTEYRITVTAHT-DVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVP 724

Query: 478  -----DAESFQMHITQEGAGNSR----------------VEITTNQSIIIGGLFPGTKYC 516
                     +Q+H  +   G  +                 + TT   +II GL P T Y 
Sbjct: 725  NKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYS 784

Query: 517  FEIVPKGPNGTEGASRTVCNRTVPSAVFDIHVVYVTTTEM---WLDWKSPDGASEYV--Y 571
              +      G    S+     T  +      +V +  T+M    + W  P      +  Y
Sbjct: 785  LTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLV-INHTQMNTALIQWHPPVDTFGPLQGY 843

Query: 572  HLVIESKHGSNHT----STYDKAITLQGLIPGTLYNITISPEVDHVWGDPNSTAQYTRPS 627
             L    K     T    S  +   T   +  G  Y   +S      +G+     + + P 
Sbjct: 844  RLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGE-EMVKEISIPE 902

Query: 628  NV-----SNI-DVSTNTTAATLSWQNFDDASPTYSYCLLIEKAGNSSNATQVVTDIGI-- 679
             V      N+    T +T+  LSWQ            +L E+ G  +  T +  DI I  
Sbjct: 903  EVPTGFPQNLHSEGTTSTSVQLSWQP----------PVLAERNGIITKYTLLYRDINIPL 952

Query: 680  -----------TDATVTELIPGSSYTVEIFAQVGDGIKSLEPGR--KSFCTDPASMASFD 726
                       T  T+T L P ++Y V++ A    G     P    ++   D     +F 
Sbjct: 953  LPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFH 1012

Query: 727  CEVVPKEPALVLKWTCPPGANAGFELEVSSGAWNNATHLESCSSENGTEYRTEVTYLNFS 786
             + V K   L L W  P   N+    ++    +++   +E     +G   +  +  L   
Sbjct: 1013 VKAVMKTSVL-LSWEIPENYNSAMPFKI---LYDDGKMVEEV---DGRATQKLIVNLKPE 1065

Query: 787  TSYNISITT---VSCGKMAAPTRNTCTTGITDPPPPDGSPNITSVSHNSVKVKFSGFEAS 843
             SY+  +T     + G     T  T    +   P   G  N+  +    + V+     A+
Sbjct: 1066 KSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGM----ITVQLPEVPAN 1121

Query: 844  HGPIKAYAVIL-----TTGEAGHPSADVLKYTYEDFKKGASDTY--VTYLIRTEEKGRSQ 896
               IK Y +I+     + G+   P     +   ++  K  S     + Y    E K    
Sbjct: 1122 EN-IKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIA 1180

Query: 897  SLSEVLKYEIDVGNESTTLGYYNGKLEPLGSYRACVAGFTNITFHPQNKGLIDGAESYV- 955
            +  +VL  E  +G++    G+ N +L+    Y   V              +++ AES + 
Sbjct: 1181 AHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLA------------VMEHAESKMY 1228

Query: 956  SFSRYSD-AVSLPQDPGVIC----------GAVFGCIFGALVIVTVGGFIFWRKKRKDAK 1004
            + S YSD  VS+  DP  I           G V   +F   +++ +   + +++KR ++ 
Sbjct: 1229 ATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAI---LLYKRKRAESD 1285

Query: 1005 NNEVSFSQIK------PKKSKLIRVENFEA----------------YFKKQQADSNCGFA 1042
            + + S    K      P     +R  NF+                 + ++ +A+ N  F+
Sbjct: 1286 SRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFS 1345

Query: 1043 EEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLS-VQTHSTDDYINANYMP 1101
            +EYE +   G       + L  N+ KNRY NV+ YD SRV LS ++     DY+NANY+ 
Sbjct: 1346 QEYESID-PGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYID 1404

Query: 1102 GYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDY 1161
            GY  +  +IATQG LP T  DFWRM+WE+    ++M+TK  E+ R KC++YWPS+  + +
Sbjct: 1405 GYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETH 1464

Query: 1162 GDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYL 1221
            G + V +   + L  + +R F +    +SE   +RQF FT+WPDHGVP+     + F   
Sbjct: 1465 GLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAF--- 1521

Query: 1222 VRDYMKQSPPES-PILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPL 1280
            +R     +PP++ P++VHCSAGVGRTG FI ID ++ +I++E TVD+YG V  +R  R  
Sbjct: 1522 LRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNY 1581

Query: 1281 MVQTEDQYVFLNQCVLDIV 1299
            MVQTEDQY+F++  +L+ V
Sbjct: 1582 MVQTEDQYIFIHDALLEAV 1600



 Score =  209 bits (533), Expect = 1e-53
 Identities = 111/287 (38%), Positives = 168/287 (58%), Gaps = 6/287 (2%)

Query: 1021 IRVENFEAYFKK----QQADSNCGFAEEYEDLKLVGISQPKY-AAELAENRGKNRYNNVL 1075
            +   N  AY +K    +  ++  G   E++ L        ++ +A L  N+ KNR  N++
Sbjct: 1607 VPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIM 1666

Query: 1076 PYDISRVKLS-VQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYA 1134
            PY+ +RV L  ++     DYINA+++ GY  +K +IATQGPL  T +DFWRM+WE N   
Sbjct: 1667 PYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTI 1726

Query: 1135 IIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHP 1194
            ++MLTK  E GR KC +YWP++++  Y    V   +E  +P++ +R+F V + +  +S  
Sbjct: 1727 VVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRT 1786

Query: 1195 LRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDR 1254
            +RQF FT WP+ GVP + +  I+F   V    +Q   + PI VHCSAGVGRTG FI +  
Sbjct: 1787 VRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSI 1846

Query: 1255 LIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRS 1301
            ++ ++  E  VD++  V  LR  RP MVQTEDQY F  +  L+ + S
Sbjct: 1847 VLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS 1893



 Score = 65.9 bits (159), Expect = 3e-10
 Identities = 103/472 (21%), Positives = 173/472 (36%), Gaps = 39/472 (8%)

Query: 424 LRSSTFYNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDAESFQ 483
           +R S  Y       LG IE     + V   P P     VT  + T I L W S + E   
Sbjct: 281 VRQSANYTCVAMSTLGVIEAIAQ-ITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVS 339

Query: 484 MHITQEGAGNS-----RVEITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRT 538
            +I Q    NS      ++        + GL P + Y F +V     G    S  V  +T
Sbjct: 340 YYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQT 399

Query: 539 ----VPSAVFDIHVVYVTTTEMWLDWKSPDGASEY-----VYHLVIESKHGSN---HTST 586
                 SA  D+    +++T + + WK P+  +       VY+ +  ++H +N   H   
Sbjct: 400 SEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVA 459

Query: 587 YDKAITLQGLIPGTLYNITISPEVDHVWGDPNSTAQYTRPSNVSNIDVS-----TNTTAA 641
             +  T+  L+P   Y++ +        G  +S  Q    + V    ++      + T+ 
Sbjct: 460 DSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSI 519

Query: 642 TLSWQNFDDASPTYSYCLLIEKAGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQ- 700
            LSW      S T +   L+ K G      ++  + G T   +  L P S Y   + A+ 
Sbjct: 520 LLSWT--PPRSDTIANYELVYKDGEHGEEQRITIEPG-TSYRLQGLKPNSLYYFRLAARS 576

Query: 701 -VGDGIKSLEPGRKSFCTDPASMASFDCEVVPKEPALVLKWTCPP-----GANAGFELEV 754
             G G  + E   ++  + P++         P   ++++ W  PP     G    + ++ 
Sbjct: 577 PQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKY 636

Query: 755 SS-GAWNNATHLESCSSENGTEYRTEVTYLNFSTSYNISITT-VSCGKMAAPTRNTCTTG 812
           ++    ++  H       + T+Y  E   L   T Y I++T     G           T 
Sbjct: 637 TAVDGEDDKPHEILGIPSDTTKYLLE--QLEKWTEYRITVTAHTDVGPGPESLSVLIRTN 694

Query: 813 ITDPPPPDGSPNITSVSHNSVKVKFSG--FEASHGPIKAYAVILTTGEAGHP 862
              P  P     + +V+  SVKV +        HG I+ Y V     E G P
Sbjct: 695 EDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEP 746


>gi|104487611 protein tyrosine phosphatase, receptor type, sigma
            isoform 4 precursor [Homo sapiens]
          Length = 1505

 Score =  258 bits (659), Expect = 3e-68
 Identities = 259/982 (26%), Positives = 411/982 (41%), Gaps = 141/982 (14%)

Query: 407  TDSSNLNVSEPRAVIPGLRSSTFYNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVS 466
            T   ++ V      +  ++ S  Y       LG IE          P  P +   VT  +
Sbjct: 277  TPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPM-VTENT 335

Query: 467  TTEIGLAWSSHDAESFQMHI------TQEGAGNSRVEITTNQSIIIGGLFPGTKYCFEIV 520
             T I + W S + +    ++      +Q+G    + +ITT +   IGGL P ++Y   + 
Sbjct: 336  ATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTR-YSIGGLSPNSEYEIWVS 394

Query: 521  PKGPNGTEGASRTVCNRT----VPSAVFDIHVVYVTTTEMWLDWKSPDGASE----YVYH 572
                 G    S +V  RT      SA  ++    ++ T M + W+ P   +     Y  +
Sbjct: 395  AVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVY 454

Query: 573  LVIESKH--GSNHTSTYDKAI--TLQGLIPGTLYNITI---SPEVDHVWGDPNST-AQYT 624
              +E +H  G+      D ++  T+  L+    Y + +   +   D    DP     Q  
Sbjct: 455  YTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQG 514

Query: 625  RPSNVSNIDVSTNT-TAATLSWQNFDDASPTYSYCLLIEKAGNSSNATQVVTDIGITDAT 683
             P    N+     + T+ TLSW      S    Y LL  +  +     +       T   
Sbjct: 515  VPGQPMNLRAEARSETSITLSWSPPRQES-IIKYELLFREGDHGREVGRTFDPT--TSYV 571

Query: 684  VTELIPGSSYTVEIFAQVGDGIKSLEPGRKSFCTDPASMASFDCEVVPKEPALVLKWTCP 743
            V +L P + Y   + A+   G+ +  P  +       S  +F  +++ K   L L W  P
Sbjct: 572  VEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSISPKNFKVKMIMKTSVL-LSWEFP 630

Query: 744  PGANAGFELEVSSGAWNNATHLESCSSENGTEYRTEVTYLNFSTSYNISITTVSCGKMAA 803
               N+    ++    +N  T        +G   +  +T+L   T YN  +T  + G    
Sbjct: 631  DNYNSPTPYKIQ---YNGLT-----LDVDGRTTKKLITHLKPHTFYNFVLT--NRGSSLG 680

Query: 804  PTRNTCTTGITDPPPPDGSPNITSVSHNSVKVKFSGF-------EASHGPIKAYAVILTT 856
              + T T   T     +G P++        K    GF         S  P+++Y +++  
Sbjct: 681  GLQQTVTAW-TAFNLLNGKPSVAP------KPDADGFIMVYLPDGQSPVPVQSYFIVMVP 733

Query: 857  GEAGHPSADVLKYTYEDFKKGASDTYVTYLIRTEEKGRSQSLSEVLKYEIDVGNESTTLG 916
                              +K     ++T L   E+      L E+++   D+        
Sbjct: 734  -----------------LRKSRGGQFLTPLGSPED----MDLEELIQ---DISRLQRRSL 769

Query: 917  YYNGKLEPLGSYRACVAGFTNITFHP---------QNKGLIDGAESYVSF---------- 957
             ++ +LE    Y A        TFHP          N+GL  G   YV F          
Sbjct: 770  RHSRQLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPG-HRYVLFVLAVLQKSEP 828

Query: 958  ----SRYSDAVSL--PQDPGVICGA-----VFGCIFGALVIVTVGGFIFWRKKRKDAKN- 1005
                S +SD   L  P    ++ G      V G +   + I+ +   I   K + D+K  
Sbjct: 829  TFAASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRK 888

Query: 1006 ----------NEVSFSQIKPKKSKLIRVENFEA----------------YFKKQQADSNC 1039
                      N    +   PK    +R  NF+                 + ++ +A+ + 
Sbjct: 889  DSEPRTKCLLNNADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSL 948

Query: 1040 GFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLS-VQTHSTDDYINAN 1098
              ++EYE +   G       + L  N+ KNRY NV+ YD SRV L  ++     DYINAN
Sbjct: 949  KLSQEYESID-PGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINAN 1007

Query: 1099 YMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQA 1158
            Y+ GY  +  +IATQGPLP T  DFWRMVWE+    I+M+T+  E+ R KC++YWP++  
Sbjct: 1008 YVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGT 1067

Query: 1159 QDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINF 1218
            + YG I V +   I L  + +R F++    +SE   +RQF FT+WPDHGVP+     + F
Sbjct: 1068 ETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAF 1127

Query: 1219 RYLVRDYMKQSPPES-PILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMH 1277
               +R     +PP++ PI+VHCSAGVGRTG FI ID ++ +I+ E TVDVYG V  +R  
Sbjct: 1128 ---LRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQ 1184

Query: 1278 RPLMVQTEDQYVFLNQCVLDIV 1299
            R  MVQTEDQY F+++ +L+ V
Sbjct: 1185 RNYMVQTEDQYSFIHEALLEAV 1206



 Score =  210 bits (534), Expect = 8e-54
 Identities = 104/244 (42%), Positives = 152/244 (62%), Gaps = 1/244 (0%)

Query: 1059 AAELAENRGKNRYNNVLPYDISRVKLS-VQTHSTDDYINANYMPGYHSKKDFIATQGPLP 1117
            +A L  N+ KNR  N++PY+ +RV L  ++     DYINA+++ GY  +K +IATQGPL 
Sbjct: 1256 SANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLA 1315

Query: 1118 NTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEW 1177
             T +DFWRM+WE N   ++MLTK  E GR KC +YWP++++  Y    V   +E  +P++
Sbjct: 1316 ETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQY 1375

Query: 1178 TIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILV 1237
             +R+F V + +  +S  +RQF FT WP+ GVP + +  I+F   V    +Q   + PI V
Sbjct: 1376 ILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISV 1435

Query: 1238 HCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLD 1297
            HCSAGVGRTG FI +  ++ ++  E  VD++  V  LR  RP MVQTED+Y F  Q  L+
Sbjct: 1436 HCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALE 1495

Query: 1298 IVRS 1301
             + S
Sbjct: 1496 YLGS 1499



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 75/318 (23%), Positives = 120/318 (37%), Gaps = 24/318 (7%)

Query: 328 TEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTN----AIQVFDVTAVNISATSLT 383
           T   + GL P + Y   V +  + G     +++  RT     A    +V A  +SAT++ 
Sbjct: 376 TRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMI 435

Query: 384 LIWKVSDNESSSNYTYKI-------HVAGETDSSNLNVSEPRAVIPGLRSSTFYNITVCP 436
           + W+     +     Y++       H  G     N++ S    V   L   T Y + V  
Sbjct: 436 VQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDET-YTVRVLA 494

Query: 437 VLGDIEGTPGF-LQVHTP---PVPVSDFRVTVVSTTEIGLAWSSHDAESFQMH--ITQEG 490
                +G     +QV T    P    + R    S T I L+WS    ES   +  + +EG
Sbjct: 495 FTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREG 554

Query: 491 AGNSRVEITTNQ--SIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTVPS-AVFDIH 547
                V  T +   S ++  L P T+Y F +  + P G    +  V  RT+ S +  +  
Sbjct: 555 DHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSISPKNFK 614

Query: 548 VVYVTTTEMWLDWKSPDG-ASEYVYHLVIESKHGSNHTSTYDKAITLQGLIPGTLYNITI 606
           V  +  T + L W+ PD   S   Y +            T  K IT   L P T YN  +
Sbjct: 615 VKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKKLIT--HLKPHTFYNFVL 672

Query: 607 SPEVDHVWGDPNSTAQYT 624
           +     + G   +   +T
Sbjct: 673 TNRGSSLGGLQQTVTAWT 690


>gi|104487295 protein tyrosine phosphatase, receptor type, sigma
            isoform 3 precursor [Homo sapiens]
          Length = 1501

 Score =  258 bits (659), Expect = 3e-68
 Identities = 259/982 (26%), Positives = 411/982 (41%), Gaps = 141/982 (14%)

Query: 407  TDSSNLNVSEPRAVIPGLRSSTFYNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVS 466
            T   ++ V      +  ++ S  Y       LG IE          P  P +   VT  +
Sbjct: 273  TPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPM-VTENT 331

Query: 467  TTEIGLAWSSHDAESFQMHI------TQEGAGNSRVEITTNQSIIIGGLFPGTKYCFEIV 520
             T I + W S + +    ++      +Q+G    + +ITT +   IGGL P ++Y   + 
Sbjct: 332  ATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTR-YSIGGLSPNSEYEIWVS 390

Query: 521  PKGPNGTEGASRTVCNRT----VPSAVFDIHVVYVTTTEMWLDWKSPDGASE----YVYH 572
                 G    S +V  RT      SA  ++    ++ T M + W+ P   +     Y  +
Sbjct: 391  AVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVY 450

Query: 573  LVIESKH--GSNHTSTYDKAI--TLQGLIPGTLYNITI---SPEVDHVWGDPNST-AQYT 624
              +E +H  G+      D ++  T+  L+    Y + +   +   D    DP     Q  
Sbjct: 451  YTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQG 510

Query: 625  RPSNVSNIDVSTNT-TAATLSWQNFDDASPTYSYCLLIEKAGNSSNATQVVTDIGITDAT 683
             P    N+     + T+ TLSW      S    Y LL  +  +     +       T   
Sbjct: 511  VPGQPMNLRAEARSETSITLSWSPPRQES-IIKYELLFREGDHGREVGRTFDPT--TSYV 567

Query: 684  VTELIPGSSYTVEIFAQVGDGIKSLEPGRKSFCTDPASMASFDCEVVPKEPALVLKWTCP 743
            V +L P + Y   + A+   G+ +  P  +       S  +F  +++ K   L L W  P
Sbjct: 568  VEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSISPKNFKVKMIMKTSVL-LSWEFP 626

Query: 744  PGANAGFELEVSSGAWNNATHLESCSSENGTEYRTEVTYLNFSTSYNISITTVSCGKMAA 803
               N+    ++    +N  T        +G   +  +T+L   T YN  +T  + G    
Sbjct: 627  DNYNSPTPYKIQ---YNGLT-----LDVDGRTTKKLITHLKPHTFYNFVLT--NRGSSLG 676

Query: 804  PTRNTCTTGITDPPPPDGSPNITSVSHNSVKVKFSGF-------EASHGPIKAYAVILTT 856
              + T T   T     +G P++        K    GF         S  P+++Y +++  
Sbjct: 677  GLQQTVTAW-TAFNLLNGKPSVAP------KPDADGFIMVYLPDGQSPVPVQSYFIVMVP 729

Query: 857  GEAGHPSADVLKYTYEDFKKGASDTYVTYLIRTEEKGRSQSLSEVLKYEIDVGNESTTLG 916
                              +K     ++T L   E+      L E+++   D+        
Sbjct: 730  -----------------LRKSRGGQFLTPLGSPED----MDLEELIQ---DISRLQRRSL 765

Query: 917  YYNGKLEPLGSYRACVAGFTNITFHP---------QNKGLIDGAESYVSF---------- 957
             ++ +LE    Y A        TFHP          N+GL  G   YV F          
Sbjct: 766  RHSRQLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPG-HRYVLFVLAVLQKSEP 824

Query: 958  ----SRYSDAVSL--PQDPGVICGA-----VFGCIFGALVIVTVGGFIFWRKKRKDAKN- 1005
                S +SD   L  P    ++ G      V G +   + I+ +   I   K + D+K  
Sbjct: 825  TFAASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRK 884

Query: 1006 ----------NEVSFSQIKPKKSKLIRVENFEA----------------YFKKQQADSNC 1039
                      N    +   PK    +R  NF+                 + ++ +A+ + 
Sbjct: 885  DSEPRTKCLLNNADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSL 944

Query: 1040 GFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLS-VQTHSTDDYINAN 1098
              ++EYE +   G       + L  N+ KNRY NV+ YD SRV L  ++     DYINAN
Sbjct: 945  KLSQEYESID-PGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINAN 1003

Query: 1099 YMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQA 1158
            Y+ GY  +  +IATQGPLP T  DFWRMVWE+    I+M+T+  E+ R KC++YWP++  
Sbjct: 1004 YVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGT 1063

Query: 1159 QDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINF 1218
            + YG I V +   I L  + +R F++    +SE   +RQF FT+WPDHGVP+     + F
Sbjct: 1064 ETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAF 1123

Query: 1219 RYLVRDYMKQSPPES-PILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMH 1277
               +R     +PP++ PI+VHCSAGVGRTG FI ID ++ +I+ E TVDVYG V  +R  
Sbjct: 1124 ---LRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQ 1180

Query: 1278 RPLMVQTEDQYVFLNQCVLDIV 1299
            R  MVQTEDQY F+++ +L+ V
Sbjct: 1181 RNYMVQTEDQYSFIHEALLEAV 1202



 Score =  210 bits (534), Expect = 8e-54
 Identities = 104/244 (42%), Positives = 152/244 (62%), Gaps = 1/244 (0%)

Query: 1059 AAELAENRGKNRYNNVLPYDISRVKLS-VQTHSTDDYINANYMPGYHSKKDFIATQGPLP 1117
            +A L  N+ KNR  N++PY+ +RV L  ++     DYINA+++ GY  +K +IATQGPL 
Sbjct: 1252 SANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLA 1311

Query: 1118 NTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEW 1177
             T +DFWRM+WE N   ++MLTK  E GR KC +YWP++++  Y    V   +E  +P++
Sbjct: 1312 ETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQY 1371

Query: 1178 TIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILV 1237
             +R+F V + +  +S  +RQF FT WP+ GVP + +  I+F   V    +Q   + PI V
Sbjct: 1372 ILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISV 1431

Query: 1238 HCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLD 1297
            HCSAGVGRTG FI +  ++ ++  E  VD++  V  LR  RP MVQTED+Y F  Q  L+
Sbjct: 1432 HCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALE 1491

Query: 1298 IVRS 1301
             + S
Sbjct: 1492 YLGS 1495



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 75/318 (23%), Positives = 120/318 (37%), Gaps = 24/318 (7%)

Query: 328 TEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTN----AIQVFDVTAVNISATSLT 383
           T   + GL P + Y   V +  + G     +++  RT     A    +V A  +SAT++ 
Sbjct: 372 TRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMI 431

Query: 384 LIWKVSDNESSSNYTYKI-------HVAGETDSSNLNVSEPRAVIPGLRSSTFYNITVCP 436
           + W+     +     Y++       H  G     N++ S    V   L   T Y + V  
Sbjct: 432 VQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDET-YTVRVLA 490

Query: 437 VLGDIEGTPGF-LQVHTP---PVPVSDFRVTVVSTTEIGLAWSSHDAESFQMH--ITQEG 490
                +G     +QV T    P    + R    S T I L+WS    ES   +  + +EG
Sbjct: 491 FTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREG 550

Query: 491 AGNSRVEITTNQ--SIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTVPS-AVFDIH 547
                V  T +   S ++  L P T+Y F +  + P G    +  V  RT+ S +  +  
Sbjct: 551 DHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSISPKNFK 610

Query: 548 VVYVTTTEMWLDWKSPDG-ASEYVYHLVIESKHGSNHTSTYDKAITLQGLIPGTLYNITI 606
           V  +  T + L W+ PD   S   Y +            T  K IT   L P T YN  +
Sbjct: 611 VKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKKLIT--HLKPHTFYNFVL 668

Query: 607 SPEVDHVWGDPNSTAQYT 624
           +     + G   +   +T
Sbjct: 669 TNRGSSLGGLQQTVTAWT 686


>gi|222537743 protein tyrosine phosphatase, receptor type, Q [Homo
            sapiens]
          Length = 2299

 Score =  256 bits (655), Expect = 8e-68
 Identities = 289/1132 (25%), Positives = 465/1132 (41%), Gaps = 149/1132 (13%)

Query: 309  HDESLVGPVDPSSGQQSRDTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQ 368
            +D +L GP +  S   S D  ++L  L P T Y+    ++   G  G    + F T+   
Sbjct: 1184 YDLTLQGPNENYSFITS-DNYIILEELSPFTLYSFFAAARTRKGL-GPSSILFFYTDESV 1241

Query: 369  VF----DVTAVNISATSLTLIWKVSDNESS--SNYTYKIHVAGETDS---SNLNVSEPRA 419
                  ++T +N ++  + L W  S         Y++KIH   ETD+    N++  +  A
Sbjct: 1242 PLAPPQNLTLINCTSDFVWLKWSPSPLPGGIVKVYSFKIH-EHETDTIYYKNISGFKTEA 1300

Query: 420  VIPGLRSSTFYNITVCPVL-----GDIEGTPGFLQVHTPPVPVSDFRVTVVSTTEIGLAW 474
             + GL   + Y+I V                 F    + P  V + +    S   + + W
Sbjct: 1301 KLVGLEPVSTYSIRVSAFTKVGNGNQFSNVVKFTTQESVPDVVQNMQCMATSWQSVLVKW 1360

Query: 475  SSHDAES---FQMHITQEGAGNSRVEITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGAS 531
                  +    Q  +T E   NS      +       L   T Y F++      G EG  
Sbjct: 1361 DPPKKANGIITQYMVTVER--NSTKVSPQDHMYTFIKLLANTSYVFKVRASTSAG-EGDE 1417

Query: 532  RTVCN-----RTVPSAVFDIHVVYVTTTEMWLDWKSPDGASEYVYHLVIESKHGSNHTST 586
             T C+      TVPS   +I    V +T   L W  PD    Y  +  I ++  +     
Sbjct: 1418 ST-CHVSTLPETVPSVPTNIAFSDVQSTSATLTWIRPDTILGYFQNYKITTQLRAQKCKE 1476

Query: 587  YDKAI------------------TLQGLIPGTLYNITISPEVDHVWGDPN---STAQYTR 625
            ++                     T+ GL     Y   ++   +  +G+ +   ST     
Sbjct: 1477 WESEECVEYQKIQYLYEAHLTEETVYGLKKFRWYRFQVAASTNAGYGNASNWISTKTLPG 1536

Query: 626  PSN--VSNIDV-STNTTAATLSWQNFDDASPTYSYCLLIEKAGNSS-NATQVVTDIGITD 681
            P +    N+ V +T+  + ++SW      +    Y + ++   N   N + + ++     
Sbjct: 1537 PPDGPPENVHVVATSPFSISISWSEPAVITGPTCYLIDVKSVDNDEFNISFIKSNEENKT 1596

Query: 682  ATVTELIPGSSYTVEIFAQVGDGIKSLEPGRKSFCTDPASMASFDCEVVPKEPALVLKWT 741
              + +L   + Y+V I A  G+   +   G+ S     A M     E  PK+P   + + 
Sbjct: 1597 IEIKDLEIFTRYSVVITAFTGNISAAYVEGKSS-----AEMIVTTLESAPKDPPNNMTFQ 1651

Query: 742  CPPGANAGFELEVSSGAWNNAT-------------------HLESCSSENGTEYRTEVTY 782
              P     F+L     +  N                     H  S   +  T     +  
Sbjct: 1652 KIPDEVTKFQLTFLPPSQPNGNIQVYQALVYREDDPTAVQIHNLSIIQKTNTFVIAMLEG 1711

Query: 783  LNFSTSYNISITTVSCGKMAAPTRNTCTTGITDPPPPDGSPN----------ITSVSHNS 832
            L    +YNIS+  V+            T  I  P  P   P           +TS +  +
Sbjct: 1712 LKGGHTYNISVYAVNSAGAGPKVPMRITMDIKAPARPKTKPTPIYDATGKLLVTSTTI-T 1770

Query: 833  VKVKFSGFEASHGPIKAYAVILTTGEAGHPSADVLKYTYEDFKKGASDTYVTYLIRTEEK 892
            +++    +   HGPIK   V++T   A H   +V K+    F K     Y T       +
Sbjct: 1771 IRMPICYYSDDHGPIKNVQVLVTETGAQH-DGNVTKWYDAYFNKARP--YFT------NE 1821

Query: 893  GRSQSLSEVLKYEIDVGNESTTLGYYNGKLEPLGSYRACVAGFTNITFHPQNKGLIDGAE 952
            G         K +     E   +G  N  + P    + C     N    P+ + L     
Sbjct: 1822 GFPNPPCTEGKTKFSGNEEIYIIGADNACMIPGNEDKIC-----NGPLKPKKQYLFKFRA 1876

Query: 953  SYV----SFSRYSDAVS-----LPQDPGVICGAVFGCIFGALVIVT-VGGFIFWRKKRKD 1002
            + +    + S YSD V      L +    I  +V  CI   +++ T +  F   R+K+K+
Sbjct: 1877 TNIMGQFTDSDYSDPVKTLGEGLSERTVEIILSVTLCILSIILLGTAIFAFARIRQKQKE 1936

Query: 1003 AKNNEVSFSQIKPKKSKL----------------------------IRVENFEAYFKKQQ 1034
                    ++I   K KL                            I  ++F  + ++  
Sbjct: 1937 GGTYSPQDAEIIDTKLKLDQLITVADLELKDERLTRLLSYRKSIKPISKKSFLQHVEELC 1996

Query: 1035 ADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLSVQTHST-DD 1093
             ++N  F EE+ +L           A+L  NR KNR+ N+ PY+ +RVKL         D
Sbjct: 1997 TNNNLKFQEEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSD 2056

Query: 1094 YINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYW 1153
            YINA+Y+ GY    +FIATQGPLP T+ DFWRMVWE     ++MLT+C E+GR +C +YW
Sbjct: 2057 YINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYW 2116

Query: 1154 P--SKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDT 1211
            P  +K    +GDI +    E V  +WTIRD  ++  +  +   +RQ +FT+WP+HGVP+ 
Sbjct: 2117 PEDNKPVTVFGDIVITKLMEDVQIDWTIRDLKIE--RHGDCMTVRQCNFTAWPEHGVPEN 2174

Query: 1212 TDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIV 1271
            +  LI+F  LVR    ++   +P++VHCSAGVGRTG FIA+D L   I + + VD+YG+V
Sbjct: 2175 SAPLIHFVKLVR--ASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLV 2232

Query: 1272 YDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQKDSKVDLIYQNTTAMTIYENL 1323
             +LR  R  MVQ   QY+FL+QC+LD++ S K S   + + N +A+   ++L
Sbjct: 2233 AELRSERMCMVQNLAQYIFLHQCILDLL-SNKGSNQPICFVNYSALQKMDSL 2283



 Score = 52.0 bits (123), Expect = 4e-06
 Identities = 104/445 (23%), Positives = 176/445 (39%), Gaps = 48/445 (10%)

Query: 442 EGTPGFLQVHTP---PVPVSDFRVTVVSTTEIGLAWSSHDAESFQM-HIT---QEGAGNS 494
           EG P  L V T    P  +       +S++ I L W   +  + ++ H T    E   N 
Sbjct: 554 EGPPTVLSVRTRQQVPSSIKIINYKNISSSSILLYWDPPEYPNGKITHYTIYAMELDTNR 613

Query: 495 RVEITT-NQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRT--VCNRTVP----SAVFDIH 547
             +ITT + S +I GL   TKY   +      G    S    +  RT      S+  D+ 
Sbjct: 614 AFQITTIDNSFLITGLKKYTKYKMRVAASTHVGESSLSEENDIFVRTSEDEPESSPQDVE 673

Query: 548 VVYVTTTEMWLDWKSPDGASEYVYHLVIESKHGSN----HTSTYDKAITLQGLIPGTLYN 603
           V+ VT  E+ L W  P+  +  +    +  K+       +TST D  I L+ L P TLYN
Sbjct: 674 VIDVTADEIRLKWSPPEKPNGIIIAYEVLYKNIDTLYMKNTSTTD--IILRNLRPHTLYN 731

Query: 604 ITISPEVDHVWGDPNSTAQYTRPSNVSNIDVSTNTTAATLSWQNFD-----DASPT---Y 655
           I++        G+  S+    R S         N T   +S    +      +SP     
Sbjct: 732 ISVRSYTRFGHGNQVSSLLSVRTSETVPDSAPENITYKNISSGEIELSFLPPSSPNGIIQ 791

Query: 656 SYCLLIEKAGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQV--GDGIKSLEPGRK 713
            Y + ++++  +   T   T +      +  L   + Y +E+ A    G+G++S      
Sbjct: 792 KYTIYLKRSNGNEERTINTTSL---TQNIKVLKKYTQYIIEVSASTLKGEGVRS---API 845

Query: 714 SFCTDPASMASFDCEVVPKEPALV---LKWTCPPGANAGFELEVSSGAWNNATHLESCSS 770
           S  T+  +  S   +   K+ + V   L W  PP    G  L  +   WN +    S  +
Sbjct: 846 SILTEEDAPDSPPQDFSVKQLSGVTVKLSWQ-PPLEPNGIILYYTVYVWNRS----SLKT 900

Query: 771 ENGTEYRTEVTYLNFSTSYNISITTVSCGKMAAPTRNTCTTGITDPPPPDGSPN---ITS 827
            N TE   E++ L+++  Y+ +  T S       TR+   +  T    P   P      +
Sbjct: 901 INVTETSLELSDLDYNVEYS-AYVTASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYAN 959

Query: 828 VSHNSVKVKFSGFEASHGPIKAYAV 852
           +S +S+ + ++     +G I+ Y+V
Sbjct: 960 LSSSSIILFWTPPSKPNGIIQYYSV 984



 Score = 45.8 bits (107), Expect = 3e-04
 Identities = 59/293 (20%), Positives = 110/293 (37%), Gaps = 20/293 (6%)

Query: 373  TAVNISATSLTLIWKVSDNESSSNYTYKIHVAGETDSSNLNVSEPRAVIPGLRSSTFYNI 432
            T  N+S+TS+ L W      + +  +Y + + G  ++ +   S+   ++  L   T Y+ 
Sbjct: 1158 TFKNLSSTSVLLSWDPPVKPNGAIISYDLTLQGPNENYSFITSDNYIILEELSPFTLYSF 1217

Query: 433  TVCPVLGDIEGTPGFLQVHT----PPVPVSDFRVTVVSTTEIGLAWSSHDAE-------S 481
                      G    L  +T    P  P  +  +   ++  + L WS            S
Sbjct: 1218 FAAARTRKGLGPSSILFFYTDESVPLAPPQNLTLINCTSDFVWLKWSPSPLPGGIVKVYS 1277

Query: 482  FQMHITQEGAGNSRVEITTNQSIIIGGLFPGTKYCFEI--VPKGPNGTEGAS--RTVCNR 537
            F++H  +      +          + GL P + Y   +    K  NG + ++  +     
Sbjct: 1278 FKIHEHETDTIYYKNISGFKTEAKLVGLEPVSTYSIRVSAFTKVGNGNQFSNVVKFTTQE 1337

Query: 538  TVPSAVFDIHVVYVTTTEMWLDWKSPDGASEYVYHLVIESKHGSNHTSTYDKAITLQGLI 597
            +VP  V ++  +  +   + + W  P  A+  +   ++  +  S   S  D   T   L+
Sbjct: 1338 SVPDVVQNMQCMATSWQSVLVKWDPPKKANGIITQYMVTVERNSTKVSPQDHMYTFIKLL 1397

Query: 598  PGTLYNITISPEVDHVWGDPN----STAQYTRPSNVSNIDVS-TNTTAATLSW 645
              T Y   +        GD +    ST   T PS  +NI  S   +T+ATL+W
Sbjct: 1398 ANTSYVFKVRASTSAGEGDESTCHVSTLPETVPSVPTNIAFSDVQSTSATLTW 1450



 Score = 40.0 bits (92), Expect = 0.015
 Identities = 129/670 (19%), Positives = 243/670 (36%), Gaps = 94/670 (14%)

Query: 119  PSPVFDIKAVSISPTNVILTWKSNDTAASEYKYVVKHKMENEKT----ITVVHQPWCNIT 174
            PS +  I   +IS ++++L W   +    +  +   + ME +      IT +   +  IT
Sbjct: 569  PSSIKIINYKNISSSSILLYWDPPEYPNGKITHYTIYAMELDTNRAFQITTIDNSFL-IT 627

Query: 175  GLRPATSYVFSITPG--IGNETWGDPRVIKVIT-EPIPVS---DLRVALTGVRKAALSWS 228
            GL+  T Y   +     +G  +  +   I V T E  P S   D+ V      +  L WS
Sbjct: 628  GLKKYTKYKMRVAASTHVGESSLSEENDIFVRTSEDEPESSPQDVEVIDVTADEIRLKWS 687

Query: 229  ---NGNGTASCRVLLESIGSHEELTQDSRLQVNISGLKPGVQYNINPYLLQSNKTKGDPL 285
                 NG      +L        +   S   + +  L+P   YNI+   ++S    G   
Sbjct: 688  PPEKPNGIIIAYEVLYKNIDTLYMKNTSTTDIILRNLRPHTLYNIS---VRSYTRFGHGN 744

Query: 286  GTEGGLDASNTERSRAGSPTAPVHDE--------SLVGPVDP-------------SSGQQ 324
                 L    +E     +P    +          S + P  P             S+G +
Sbjct: 745  QVSSLLSVRTSETVPDSAPENITYKNISSGEIELSFLPPSSPNGIIQKYTIYLKRSNGNE 804

Query: 325  SR--DTEVLLVGLEPGTRYNATVYSQAANGTEGQ-----PQAIEFRTNAIQV--FDVTAV 375
             R  +T  L   ++   +Y   +   +A+  +G+     P +I    +A      D +  
Sbjct: 805  ERTINTTSLTQNIKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSPPQDFSVK 864

Query: 376  NISATSLTLIWKVSDNESSSNYTYKIHVAGETDSSNLNVSEPRAVIPGLRSSTFYN--IT 433
             +S  ++ L W+     +     Y ++V   +    +NV+E    +  L  +  Y+  +T
Sbjct: 865  QLSGVTVKLSWQPPLEPNGIILYYTVYVWNRSSLKTINVTETSLELSDLDYNVEYSAYVT 924

Query: 434  VCPVLGDIEGTPGFLQVHTPPV----PVSDFRVTVVSTTEIGLAWSS------------- 476
                 GD +     +   TP      P  D     +S++ I L W+              
Sbjct: 925  ASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIILFWTPPSKPNGIIQYYSV 984

Query: 477  ---HDAESFQMHITQEGAGNSRVEITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRT 533
               + + +F  + T     N    +T   S II  L   + Y F +      G    S  
Sbjct: 985  YYRNTSGTFMQNFTLHEVTNDFDNMTV--STIIDKLTIFSYYTFWLTASTSVGNGNKSSD 1042

Query: 534  VC----NRTVPSA-VFDIHVVYVTTTEMWLDW---KSPDGASEYVYHLVIES--KHGSNH 583
            +     ++ +P   V ++    +++T + + W     P+G   Y   L+++   +H    
Sbjct: 1043 IIEVYTDQDIPEGFVGNLTYESISSTAINVSWVPPAQPNGLVFYYVSLILQQTPRHVRPP 1102

Query: 584  TSTYDKAITLQGLIPGTLYNITISPEVDHVWGDPNSTAQYTR-------PSNVSNIDVST 636
              TY+++I    L   T Y + I+P  +  + D  +   Y +        S + N   + 
Sbjct: 1103 LVTYERSIYFDNLEKYTDYILKITPSTEKGFSDTYTAQLYIKTEEDVPETSPIINTFKNL 1162

Query: 637  NTTAATLSWQ-NFDDASPTYSYCLLIEKAGNSSNATQVVTDIGITDATVTELIPGSSYTV 695
            ++T+  LSW           SY L ++  G + N + + +D  I    + EL P + Y+ 
Sbjct: 1163 SSTSVLLSWDPPVKPNGAIISYDLTLQ--GPNENYSFITSDNYI---ILEELSPFTLYSF 1217

Query: 696  EIFAQVGDGI 705
               A+   G+
Sbjct: 1218 FAAARTRKGL 1227



 Score = 37.4 bits (85), Expect = 0.097
 Identities = 44/178 (24%), Positives = 75/178 (42%), Gaps = 27/178 (15%)

Query: 253 SRLQVNISGLKPGVQYNIN------------PYLLQSNKTK--------GDPLGTEGGLD 292
           S  QV++S + PG +Y+I               ++ +N TK        G+ +G+ G L 
Sbjct: 15  SETQVDVSNVVPGTRYDITISSISTTYTSPVTRIVTTNVTKPGPPVFLAGERVGSAGILL 74

Query: 293 ASNTERSRAGSPTAPVHDESLVGPVDPSSGQQSRDT----EVLLVGLEPGTRYNATVYSQ 348
           + NT  +  G   + +     V P   +   Q R      EVLL  L PGT Y   V ++
Sbjct: 75  SWNTPPNPNGRIISYIVKYKEVCPWMQTVYTQVRSKPDSLEVLLTNLNPGTTYEIKVAAE 134

Query: 349 AANGTEGQPQAIEFRTNAI---QVFDVTAVNISATSLTLIWKVSDNESSSNYTYKIHV 403
            + G         F+T      +V ++T    +A+++ LIW +    +    ++KI V
Sbjct: 135 NSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIWYLPRQPNGKITSFKISV 192


>gi|148539860 protein tyrosine phosphatase, receptor type, T isoform 2
            precursor [Homo sapiens]
          Length = 1441

 Score =  247 bits (630), Expect = 6e-65
 Identities = 137/294 (46%), Positives = 178/294 (60%), Gaps = 11/294 (3%)

Query: 1008 VSFSQIKPKKSKLIRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRG 1067
            V  S  + +    IRV +   +  + +     GF EEYE L   G +     A+  ENR 
Sbjct: 856  VEMSYPRDQFQPAIRVADLLQHITQMKRGQGYGFKEEYEALP-EGQTASWDTAKEDENRN 914

Query: 1068 KNRYNNVLPYDISRVKLSV---QTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFW 1124
            KNRY N++ YD SRV+L V     HS  DYINANY+ GYH  + +IATQGP+  T+KDFW
Sbjct: 915  KNRYGNIISYDHSRVRLLVLDGDPHS--DYINANYIDGYHRPRHYIATQGPMQETVKDFW 972

Query: 1125 RMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTV 1184
            RM+W++N  +I+M+T  VE GR KC  YWP    + YGDI V +     L E+ IR FTV
Sbjct: 973  RMIWQENSASIVMVTNLVEVGRVKCVRYWPD-DTEVYGDIKVTLIETEPLAEYVIRTFTV 1031

Query: 1185 KNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPES-PILVHCSAGV 1243
            +     E   LR FHFTSWPDHGVP     L+ F   VR     +PPE+ PI+VHCSAG 
Sbjct: 1032 QKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGF---VRQVKFLNPPEAGPIVVHCSAGA 1088

Query: 1244 GRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLD 1297
            GRTG FIAID ++   ENE  VD++  V +LR  R  +VQTE+QYVF++  +L+
Sbjct: 1089 GRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILE 1142



 Score =  125 bits (313), Expect = 4e-28
 Identities = 84/283 (29%), Positives = 134/283 (47%), Gaps = 12/283 (4%)

Query: 1029 YFKKQQADSNCGFAEEYEDLKLVGISQPKYAAE------LAENRGKNRYNNVLPYDISRV 1082
            Y+   + D     ++  ++ + + I  P+   E      L  N  KNR  +VLP D    
Sbjct: 1160 YYNISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLP 1219

Query: 1083 KLSVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCV 1142
             L      + +YINA  M  +     F+ TQ PLPNT+ DFWR+V++ N  +++ML +  
Sbjct: 1220 FLISVDGESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEM- 1278

Query: 1143 EQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSES--HPLRQFHF 1200
                  C +YWP K +  YG I V   S  +  +   R F + N+   +     ++   +
Sbjct: 1279 -DTAQFCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQY 1337

Query: 1201 TSWPDHG--VPDTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQ 1258
              WP +    P    LL   R L +   +    E   +VHC  G GR+GTF AI  +   
Sbjct: 1338 IGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEM 1397

Query: 1259 IENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRS 1301
            I+ +N +DV+ IV  LR ++  MV+T +QY F+ +  L+ + S
Sbjct: 1398 IQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSS 1440



 Score = 36.6 bits (83), Expect = 0.17
 Identities = 30/107 (28%), Positives = 51/107 (47%), Gaps = 15/107 (14%)

Query: 314 VGPVDPSSGQQSR---------DTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRT 364
           VG +DPS+   S+         +T  L VGL PGT Y+ T+ +  A G  G P      T
Sbjct: 526 VGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGF-GPPVTTRIAT 584

Query: 365 N----AIQVFDV-TAVNISATSLTLIWKVSDNESSSNYTYKIHVAGE 406
                ++  +D  T +N + T++T++ K + +  +    Y++ V  E
Sbjct: 585 KISAPSMPEYDTDTPLNETDTTITVMLKPAQSRGAPVSVYQLVVKEE 631



 Score = 35.8 bits (81), Expect = 0.28
 Identities = 62/318 (19%), Positives = 126/318 (39%), Gaps = 21/318 (6%)

Query: 626 PSNVSNIDVSTNTTAATLSWQNFDDA-SPTYSYCLLIEKAGNSSNATQVVTDIGITDA-- 682
           P NV  +D+       TL W+ F  A +  +SY L ++     +       ++  T +  
Sbjct: 390 PQNVEIVDIRARQL--TLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVIQTSSHY 447

Query: 683 TVTELIPGSSYTVEIFAQVGDG-IKSLEPGRKSFCTDPASMASFDCEVVPKEPALVLKWT 741
           T+  L P  +  + +     +G ++S E   ++    P ++     +  P E  + ++W 
Sbjct: 448 TLRGLRPFMTIRLRLLLSNPEGRMESEELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWK 507

Query: 742 CPPGANAGFEL-EVSSGAWNNATHLESCSSENGTEY--RTEVTYLNFS----TSYNISIT 794
            P   N    L E++  A  +       SS+ G  +  R E  +L       T+Y+ +I 
Sbjct: 508 PPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIK 567

Query: 795 TVSCGKMAAPTRNTCTTGITDPPPPDGSPNIT-SVSHNSVKVKFSGFEASHGPIKAYAVI 853
             +      P      T I+ P  P+   +   + +  ++ V     ++   P+  Y ++
Sbjct: 568 ASTAKGFGPPVTTRIATKISAPSMPEYDTDTPLNETDTTITVMLKPAQSRGAPVSVYQLV 627

Query: 854 LTTG--EAGHPSADVLK-YTYEDFKKGASDTYVTYLIRTEEKGRSQSLSEVLKYEIDVGN 910
           +     +    +AD+++ ++     + AS     +    E K  +  +++       VG+
Sbjct: 628 VKEERLQKSRRAADIIECFSVPVSYRNASSLDSLHYFAAELKPANLPVTQ----PFTVGD 683

Query: 911 ESTTLGYYNGKLEPLGSY 928
             T  GY+N  L PL SY
Sbjct: 684 NKTYNGYWNPPLSPLKSY 701


>gi|148539858 protein tyrosine phosphatase, receptor type, T isoform 1
            precursor [Homo sapiens]
          Length = 1460

 Score =  247 bits (630), Expect = 6e-65
 Identities = 137/294 (46%), Positives = 178/294 (60%), Gaps = 11/294 (3%)

Query: 1008 VSFSQIKPKKSKLIRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRG 1067
            V  S  + +    IRV +   +  + +     GF EEYE L   G +     A+  ENR 
Sbjct: 875  VEMSYPRDQFQPAIRVADLLQHITQMKRGQGYGFKEEYEALP-EGQTASWDTAKEDENRN 933

Query: 1068 KNRYNNVLPYDISRVKLSV---QTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFW 1124
            KNRY N++ YD SRV+L V     HS  DYINANY+ GYH  + +IATQGP+  T+KDFW
Sbjct: 934  KNRYGNIISYDHSRVRLLVLDGDPHS--DYINANYIDGYHRPRHYIATQGPMQETVKDFW 991

Query: 1125 RMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTV 1184
            RM+W++N  +I+M+T  VE GR KC  YWP    + YGDI V +     L E+ IR FTV
Sbjct: 992  RMIWQENSASIVMVTNLVEVGRVKCVRYWPD-DTEVYGDIKVTLIETEPLAEYVIRTFTV 1050

Query: 1185 KNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPES-PILVHCSAGV 1243
            +     E   LR FHFTSWPDHGVP     L+ F   VR     +PPE+ PI+VHCSAG 
Sbjct: 1051 QKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGF---VRQVKFLNPPEAGPIVVHCSAGA 1107

Query: 1244 GRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLD 1297
            GRTG FIAID ++   ENE  VD++  V +LR  R  +VQTE+QYVF++  +L+
Sbjct: 1108 GRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILE 1161



 Score =  125 bits (313), Expect = 4e-28
 Identities = 84/283 (29%), Positives = 134/283 (47%), Gaps = 12/283 (4%)

Query: 1029 YFKKQQADSNCGFAEEYEDLKLVGISQPKYAAE------LAENRGKNRYNNVLPYDISRV 1082
            Y+   + D     ++  ++ + + I  P+   E      L  N  KNR  +VLP D    
Sbjct: 1179 YYNISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLP 1238

Query: 1083 KLSVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCV 1142
             L      + +YINA  M  +     F+ TQ PLPNT+ DFWR+V++ N  +++ML +  
Sbjct: 1239 FLISVDGESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEM- 1297

Query: 1143 EQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSES--HPLRQFHF 1200
                  C +YWP K +  YG I V   S  +  +   R F + N+   +     ++   +
Sbjct: 1298 -DTAQFCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQY 1356

Query: 1201 TSWPDHG--VPDTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQ 1258
              WP +    P    LL   R L +   +    E   +VHC  G GR+GTF AI  +   
Sbjct: 1357 IGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEM 1416

Query: 1259 IENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRS 1301
            I+ +N +DV+ IV  LR ++  MV+T +QY F+ +  L+ + S
Sbjct: 1417 IQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSS 1459



 Score = 36.6 bits (83), Expect = 0.17
 Identities = 30/107 (28%), Positives = 51/107 (47%), Gaps = 15/107 (14%)

Query: 314 VGPVDPSSGQQSR---------DTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRT 364
           VG +DPS+   S+         +T  L VGL PGT Y+ T+ +  A G  G P      T
Sbjct: 526 VGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGF-GPPVTTRIAT 584

Query: 365 N----AIQVFDV-TAVNISATSLTLIWKVSDNESSSNYTYKIHVAGE 406
                ++  +D  T +N + T++T++ K + +  +    Y++ V  E
Sbjct: 585 KISAPSMPEYDTDTPLNETDTTITVMLKPAQSRGAPVSVYQLVVKEE 631



 Score = 35.8 bits (81), Expect = 0.28
 Identities = 62/318 (19%), Positives = 126/318 (39%), Gaps = 21/318 (6%)

Query: 626 PSNVSNIDVSTNTTAATLSWQNFDDA-SPTYSYCLLIEKAGNSSNATQVVTDIGITDA-- 682
           P NV  +D+       TL W+ F  A +  +SY L ++     +       ++  T +  
Sbjct: 390 PQNVEIVDIRARQL--TLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVIQTSSHY 447

Query: 683 TVTELIPGSSYTVEIFAQVGDG-IKSLEPGRKSFCTDPASMASFDCEVVPKEPALVLKWT 741
           T+  L P  +  + +     +G ++S E   ++    P ++     +  P E  + ++W 
Sbjct: 448 TLRGLRPFMTIRLRLLLSNPEGRMESEELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWK 507

Query: 742 CPPGANAGFEL-EVSSGAWNNATHLESCSSENGTEY--RTEVTYLNFS----TSYNISIT 794
            P   N    L E++  A  +       SS+ G  +  R E  +L       T+Y+ +I 
Sbjct: 508 PPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIK 567

Query: 795 TVSCGKMAAPTRNTCTTGITDPPPPDGSPNIT-SVSHNSVKVKFSGFEASHGPIKAYAVI 853
             +      P      T I+ P  P+   +   + +  ++ V     ++   P+  Y ++
Sbjct: 568 ASTAKGFGPPVTTRIATKISAPSMPEYDTDTPLNETDTTITVMLKPAQSRGAPVSVYQLV 627

Query: 854 LTTG--EAGHPSADVLK-YTYEDFKKGASDTYVTYLIRTEEKGRSQSLSEVLKYEIDVGN 910
           +     +    +AD+++ ++     + AS     +    E K  +  +++       VG+
Sbjct: 628 VKEERLQKSRRAADIIECFSVPVSYRNASSLDSLHYFAAELKPANLPVTQ----PFTVGD 683

Query: 911 ESTTLGYYNGKLEPLGSY 928
             T  GY+N  L PL SY
Sbjct: 684 NKTYNGYWNPPLSPLKSY 701


>gi|157419150 protein tyrosine phosphatase, receptor type, M isoform 2
            precursor [Homo sapiens]
          Length = 1452

 Score =  244 bits (624), Expect = 3e-64
 Identities = 129/279 (46%), Positives = 170/279 (60%), Gaps = 7/279 (2%)

Query: 1021 IRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDIS 1080
            IRV +   +  + +     GF EEYE     G S P  +A+  ENR KNRY N++ YD S
Sbjct: 880  IRVADLLQHITQMKCAEGYGFKEEYESF-FEGQSAPWDSAKKDENRMKNRYGNIIAYDHS 938

Query: 1081 RVKL-SVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLT 1139
            RV+L +++  +  DYIN NY+ GYH    +IATQGP+  T+ DFWRMVW +N  +IIM+T
Sbjct: 939  RVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVT 998

Query: 1140 KCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFH 1199
              VE GR KC +YWP    + Y DI V +    +L E+ IR F V+     E   +RQFH
Sbjct: 999  NLVEVGRVKCCKYWPD-DTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFH 1057

Query: 1200 FTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPES-PILVHCSAGVGRTGTFIAIDRLIYQ 1258
            FT WPDHGVP     L+ F   VR    +SPP + P++VHCSAG GRTG FI ID ++  
Sbjct: 1058 FTGWPDHGVPYHATGLLGF---VRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDM 1114

Query: 1259 IENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLD 1297
             E E  VD+Y  V +LR  R  MVQTE+QYVF++  +L+
Sbjct: 1115 AEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILE 1153



 Score =  125 bits (314), Expect = 3e-28
 Identities = 88/285 (30%), Positives = 133/285 (46%), Gaps = 16/285 (5%)

Query: 1029 YFKKQQADSNCGFAEEYEDLKLVGISQPKYAAE------LAENRGKNRYNNVLPYDISRV 1082
            Y+   + D     ++  E+ + + +  P    E      L  N  KNR  ++LP D    
Sbjct: 1171 YYDMNKLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLP 1230

Query: 1083 KLSVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCV 1142
             L      + +YINA  M  Y     FI TQ PLPNT+KDFWR+V + +  +++ML   V
Sbjct: 1231 FLITIDGESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLND-V 1289

Query: 1143 EQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSES--HPLRQFHF 1200
            +  +  C +YWP      +G I V   S  +  +   R F + N    +     ++QF F
Sbjct: 1290 DPAQL-CPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGYRMVQQFQF 1348

Query: 1201 TSWPDHGVPDTTDLLINFRYLVRDYMK----QSPPESPILVHCSAGVGRTGTFIAIDRLI 1256
              WP +   DT     +F  L+R   K     +  E   +VHC  G GR+GTF AI  + 
Sbjct: 1349 LGWPMY--RDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVC 1406

Query: 1257 YQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRS 1301
              + ++ TVDV+  V  LR ++P MV   DQY F  +  L+ + S
Sbjct: 1407 EMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNS 1451



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 132/622 (21%), Positives = 222/622 (35%), Gaps = 109/622 (17%)

Query: 448  LQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDAESFQ----------MHITQEGAGNSRVE 497
            L V  PPVP++  ++  V  T +   W   +A S             + T  G+ N R  
Sbjct: 276  LVVKEPPVPIAPPQLASVGATYL---WIQLNANSINGDGPIVAREVEYCTASGSWNDRQP 332

Query: 498  ITTNQSIIIGGLFPGTKYCFEIV----PKGPNGTEGAS---RTVCNRTVPSAVFDIHVVY 550
            + +  S  IG L P T+Y   ++     +G  G+ G +   RT C   +      + VV 
Sbjct: 333  VDST-SYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRTKCADPMRGPR-KLEVVE 390

Query: 551  VTTTEMWLDWKSPDGASEYVYHLVIESKHGSNHTSTYDKAITLQGLIPGTLYNITISPEV 610
            V + ++ + W+ P G +       +   H  N T  Y   +  Q           +  EV
Sbjct: 391  VKSRQITIRWE-PFGYN-------VTRCHSYNLTVHYCYQVGGQE---------QVREEV 433

Query: 611  DHVWGDPNSTAQYTRPSNVSNIDVSTNTTAATLSWQNFDDASPTYSYCLLIEKAGNSSNA 670
               W   NS  Q+T    ++N+   TN +   +               L+  +    S  
Sbjct: 434  S--WDTENSHPQHT----ITNLSPYTNVSVKLI---------------LMNPEGRKESQE 472

Query: 671  TQVVTDIGITDATVTELIPGSSYTVEIFAQVGDGIKSLEPGRKSFCTDPASMASFDCEVV 730
              V TD  +  A  TE I GS++  +IF Q  +  ++         T  A ++SFD E+ 
Sbjct: 473  LIVQTDEDLPGAVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKA-VSSFDPEI- 530

Query: 731  PKEPALVLKWTCPPGANAGFELEVSSGAWNNATHLESCSSENGTEYRTEVTYLNFSTSYN 790
                                +L   SG            S+ G E       L   T+Y+
Sbjct: 531  --------------------DLSNQSGR----------VSKLGNETHFLFFGLYPGTTYS 560

Query: 791  ISITTVSCGKMAAPTRNTCTTGITDPPPPDGSPNIT-SVSHNSVKVKFSGFEASHGPIKA 849
             +I   +      P  N  TT I+ P  P        + + N+V V      +   P+  
Sbjct: 561  FTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQTDNTVTVMLKPAHSRGAPVSV 620

Query: 850  YAVILTTGEAGHP--SADVLK-YTYEDFKKGASDTYVTYLIRTEEKGRSQSLSEVLKYEI 906
            Y +++          + ++LK Y      + AS     Y    E    S   ++      
Sbjct: 621  YQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYYFAAEFPADSLQAAQ----PF 676

Query: 907  DVGNESTTLGYYNGKLEPLGSYRACVAGFTNITFHPQNKGLIDGAESYVSFSRYSDAVSL 966
             +G+  T  GY+N  L P  SYR     +         +  ID  +     +     V  
Sbjct: 677  TIGDNKTYNGYWNTPLLPYKSYRI----YFQAASRANGETKIDCVQVATKGAATPKPVPE 732

Query: 967  PQDPGVICGAVFGCIFGALVIVTVG-GFIFWRKKRKDAKNNEVSFSQIKPKKSKLIRVEN 1025
            P+        + G I G L+ V +  G +   KKRK AK  + + S  + + +  + V +
Sbjct: 733  PEKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKETMSSTRQEMT--VMVNS 790

Query: 1026 FEAYFKKQQADSNCGFAEEYED 1047
             +  + +Q   +NC  A  + D
Sbjct: 791  MDKSYAEQ--GTNCDEAFSFMD 810



 Score = 33.1 bits (74), Expect = 1.8
 Identities = 39/168 (23%), Positives = 71/168 (42%), Gaps = 29/168 (17%)

Query: 321 SGQQSR---DTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTN----AIQVFDV- 372
           SG+ S+   +T  L  GL PGT Y+ T+ +  A G  G P   +F T     ++  +++ 
Sbjct: 536 SGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGF-GPPATNQFTTKISAPSMPAYELE 594

Query: 373 TAVNISATSLTLIWKVSDNESSSNYTYKIHVAGETDSSNLNVSEPRAVIP--------GL 424
           T +N +  ++T++ K + +  +    Y+I V  E        +E     P         L
Sbjct: 595 TPLNQTDNTVTVMLKPAHSRGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASL 654

Query: 425 RSSTFYNITVCP----------VLGDIEGTPGFLQVHTPPVPVSDFRV 462
            +S +Y     P           +GD +   G+   +TP +P   +R+
Sbjct: 655 LNSQYYFAAEFPADSLQAAQPFTIGDNKTYNGYW--NTPLLPYKSYRI 700


>gi|157419152 protein tyrosine phosphatase, receptor type, M isoform 1
            precursor [Homo sapiens]
          Length = 1465

 Score =  244 bits (624), Expect = 3e-64
 Identities = 129/279 (46%), Positives = 170/279 (60%), Gaps = 7/279 (2%)

Query: 1021 IRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDIS 1080
            IRV +   +  + +     GF EEYE     G S P  +A+  ENR KNRY N++ YD S
Sbjct: 893  IRVADLLQHITQMKCAEGYGFKEEYESF-FEGQSAPWDSAKKDENRMKNRYGNIIAYDHS 951

Query: 1081 RVKL-SVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLT 1139
            RV+L +++  +  DYIN NY+ GYH    +IATQGP+  T+ DFWRMVW +N  +IIM+T
Sbjct: 952  RVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVT 1011

Query: 1140 KCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFH 1199
              VE GR KC +YWP    + Y DI V +    +L E+ IR F V+     E   +RQFH
Sbjct: 1012 NLVEVGRVKCCKYWPD-DTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFH 1070

Query: 1200 FTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPES-PILVHCSAGVGRTGTFIAIDRLIYQ 1258
            FT WPDHGVP     L+ F   VR    +SPP + P++VHCSAG GRTG FI ID ++  
Sbjct: 1071 FTGWPDHGVPYHATGLLGF---VRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDM 1127

Query: 1259 IENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLD 1297
             E E  VD+Y  V +LR  R  MVQTE+QYVF++  +L+
Sbjct: 1128 AEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILE 1166



 Score =  125 bits (314), Expect = 3e-28
 Identities = 88/285 (30%), Positives = 133/285 (46%), Gaps = 16/285 (5%)

Query: 1029 YFKKQQADSNCGFAEEYEDLKLVGISQPKYAAE------LAENRGKNRYNNVLPYDISRV 1082
            Y+   + D     ++  E+ + + +  P    E      L  N  KNR  ++LP D    
Sbjct: 1184 YYDMNKLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLP 1243

Query: 1083 KLSVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCV 1142
             L      + +YINA  M  Y     FI TQ PLPNT+KDFWR+V + +  +++ML   V
Sbjct: 1244 FLITIDGESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLND-V 1302

Query: 1143 EQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSES--HPLRQFHF 1200
            +  +  C +YWP      +G I V   S  +  +   R F + N    +     ++QF F
Sbjct: 1303 DPAQL-CPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGYRMVQQFQF 1361

Query: 1201 TSWPDHGVPDTTDLLINFRYLVRDYMK----QSPPESPILVHCSAGVGRTGTFIAIDRLI 1256
              WP +   DT     +F  L+R   K     +  E   +VHC  G GR+GTF AI  + 
Sbjct: 1362 LGWPMY--RDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVC 1419

Query: 1257 YQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRS 1301
              + ++ TVDV+  V  LR ++P MV   DQY F  +  L+ + S
Sbjct: 1420 EMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNS 1464



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 132/622 (21%), Positives = 222/622 (35%), Gaps = 109/622 (17%)

Query: 448  LQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDAESFQ----------MHITQEGAGNSRVE 497
            L V  PPVP++  ++  V  T +   W   +A S             + T  G+ N R  
Sbjct: 276  LVVKEPPVPIAPPQLASVGATYL---WIQLNANSINGDGPIVAREVEYCTASGSWNDRQP 332

Query: 498  ITTNQSIIIGGLFPGTKYCFEIV----PKGPNGTEGAS---RTVCNRTVPSAVFDIHVVY 550
            + +  S  IG L P T+Y   ++     +G  G+ G +   RT C   +      + VV 
Sbjct: 333  VDST-SYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRTKCADPMRGPR-KLEVVE 390

Query: 551  VTTTEMWLDWKSPDGASEYVYHLVIESKHGSNHTSTYDKAITLQGLIPGTLYNITISPEV 610
            V + ++ + W+ P G +       +   H  N T  Y   +  Q           +  EV
Sbjct: 391  VKSRQITIRWE-PFGYN-------VTRCHSYNLTVHYCYQVGGQE---------QVREEV 433

Query: 611  DHVWGDPNSTAQYTRPSNVSNIDVSTNTTAATLSWQNFDDASPTYSYCLLIEKAGNSSNA 670
               W   NS  Q+T    ++N+   TN +   +               L+  +    S  
Sbjct: 434  S--WDTENSHPQHT----ITNLSPYTNVSVKLI---------------LMNPEGRKESQE 472

Query: 671  TQVVTDIGITDATVTELIPGSSYTVEIFAQVGDGIKSLEPGRKSFCTDPASMASFDCEVV 730
              V TD  +  A  TE I GS++  +IF Q  +  ++         T  A ++SFD E+ 
Sbjct: 473  LIVQTDEDLPGAVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKA-VSSFDPEI- 530

Query: 731  PKEPALVLKWTCPPGANAGFELEVSSGAWNNATHLESCSSENGTEYRTEVTYLNFSTSYN 790
                                +L   SG            S+ G E       L   T+Y+
Sbjct: 531  --------------------DLSNQSGR----------VSKLGNETHFLFFGLYPGTTYS 560

Query: 791  ISITTVSCGKMAAPTRNTCTTGITDPPPPDGSPNIT-SVSHNSVKVKFSGFEASHGPIKA 849
             +I   +      P  N  TT I+ P  P        + + N+V V      +   P+  
Sbjct: 561  FTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQTDNTVTVMLKPAHSRGAPVSV 620

Query: 850  YAVILTTGEAGHP--SADVLK-YTYEDFKKGASDTYVTYLIRTEEKGRSQSLSEVLKYEI 906
            Y +++          + ++LK Y      + AS     Y    E    S   ++      
Sbjct: 621  YQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYYFAAEFPADSLQAAQ----PF 676

Query: 907  DVGNESTTLGYYNGKLEPLGSYRACVAGFTNITFHPQNKGLIDGAESYVSFSRYSDAVSL 966
             +G+  T  GY+N  L P  SYR     +         +  ID  +     +     V  
Sbjct: 677  TIGDNKTYNGYWNTPLLPYKSYRI----YFQAASRANGETKIDCVQVATKGAATPKPVPE 732

Query: 967  PQDPGVICGAVFGCIFGALVIVTVG-GFIFWRKKRKDAKNNEVSFSQIKPKKSKLIRVEN 1025
            P+        + G I G L+ V +  G +   KKRK AK  + + S  + + +  + V +
Sbjct: 733  PEKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKETMSSTRQEMT--VMVNS 790

Query: 1026 FEAYFKKQQADSNCGFAEEYED 1047
             +  + +Q   +NC  A  + D
Sbjct: 791  MDKSYAEQ--GTNCDEAFSFMD 810



 Score = 33.1 bits (74), Expect = 1.8
 Identities = 39/168 (23%), Positives = 71/168 (42%), Gaps = 29/168 (17%)

Query: 321 SGQQSR---DTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTN----AIQVFDV- 372
           SG+ S+   +T  L  GL PGT Y+ T+ +  A G  G P   +F T     ++  +++ 
Sbjct: 536 SGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGF-GPPATNQFTTKISAPSMPAYELE 594

Query: 373 TAVNISATSLTLIWKVSDNESSSNYTYKIHVAGETDSSNLNVSEPRAVIP--------GL 424
           T +N +  ++T++ K + +  +    Y+I V  E        +E     P         L
Sbjct: 595 TPLNQTDNTVTVMLKPAHSRGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASL 654

Query: 425 RSSTFYNITVCP----------VLGDIEGTPGFLQVHTPPVPVSDFRV 462
            +S +Y     P           +GD +   G+   +TP +P   +R+
Sbjct: 655 LNSQYYFAAEFPADSLQAAQPFTIGDNKTYNGYW--NTPLLPYKSYRI 700


>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
            isoform 2 precursor [Homo sapiens]
          Length = 1910

 Score =  243 bits (621), Expect = 7e-64
 Identities = 276/1097 (25%), Positives = 449/1097 (40%), Gaps = 174/1097 (15%)

Query: 328  TEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRT----NAIQVFDVTAVNISATSLT 383
            T  ++  L+P T Y   + +++  G       +  RT     +    DV  V++ +T++ 
Sbjct: 564  TSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAIL 623

Query: 384  LIWKVSDNESSSN----YTYKIHVAGETDSSNLNVS-----EPRAVIPGLRSSTFYNITV 434
            + W+    E+ +     Y+ +    G  D     V+       + ++  L   T Y IT 
Sbjct: 624  VSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITT 683

Query: 435  CP---VLGDIEGTPGFLQVH--TPPVPVSDFRVTVVSTTEIGLAWSSH-------DAESF 482
                 V    E +P  ++     P  P        ++ T I + W S            +
Sbjct: 684  VAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGY 743

Query: 483  QMH-ITQEGA---GNSRVE---ITTNQSIIIGGLFPGTKYCFEIVP---KGPNGTEGASR 532
            Q+H +  EGA   G  R++   +   Q ++I  L P T Y   +     KG +G     +
Sbjct: 744  QVHYVRMEGAEARGPPRIKDVMLADAQEMVITNLQPETAYSITVAAYTMKG-DGARSKPK 802

Query: 533  TVCNRTVPSAVFDIHVVYVTTTEMWLDWKSPDGASE---YVYHLVIESKHGSNHTSTYD- 588
             V  +        + V       +   W+ P G +E     Y L    +  S   +T + 
Sbjct: 803  VVVTKGAVLGRPTLSVQQTPEGSLLARWEPPAGTAEDQVLGYRLQF-GREDSTPLATLEF 861

Query: 589  ----KAITLQGLIPGTLYNITISPEVDHVWGDPN----STAQYTRPSNVSNIDVSTNTTA 640
                   T  G+  G  Y   ++       G+      S  + T   +   ++ + N +A
Sbjct: 862  PPSEDRYTASGVHKGATYVFRLAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASA 921

Query: 641  AT--LSWQNFDDASPT---YSYCLLIEKAGNSSNATQV----VTDIGITDA-TVTELIPG 690
             T  L W     A        Y + + +AG    A +       + G  +A T+  L P 
Sbjct: 922  GTVLLRWLPPVPAERNGAIVKYTVAVREAGALGPARETELPAAAEPGAENALTLQGLKPD 981

Query: 691  SSYTVEIFAQVGDGIKSLEPG--RKSFCTDPASMASFDCEVVPKEPALVLKWTCPPGANA 748
            ++Y +++ A    G     P    ++F  D  S  +F  +++ K   L L W  P   N+
Sbjct: 982  TAYDLQVRAHTRRGPGPFSPPVRYRTFLRDQVSPKNFKVKMIMKTSVL-LSWEFPDNYNS 1040

Query: 749  GFELEVSSGAWNNATHLESCSSENGTEYRTEVTYLNFSTSYNISITTVSCGKMAAPTRNT 808
                ++    +N  T        +G   +  +T+L   T YN  +T  + G      + T
Sbjct: 1041 PTPYKIQ---YNGLT-----LDVDGRTTKKLITHLKPHTFYNFVLT--NRGSSLGGLQQT 1090

Query: 809  CTTGITDPPPPDGSPNITSVSHNSVKVKFSGF-------EASHGPIKAYAVILTTGEAGH 861
             T   T     +G P++        K    GF         S  P+++Y +++       
Sbjct: 1091 VTAW-TAFNLLNGKPSVAP------KPDADGFIMVYLPDGQSPVPVQSYFIVMVP----- 1138

Query: 862  PSADVLKYTYEDFKKGASDTYVTYLIRTEEKGRSQSLSEVLKYEIDVGNESTTLGYYNGK 921
                         +K     ++T L   E+      L E+++   D+         ++ +
Sbjct: 1139 ------------LRKSRGGQFLTPLGSPED----MDLEELIQ---DISRLQRRSLRHSRQ 1179

Query: 922  LEPLGSYRACVAGFTNITFHP---------QNKGLIDGAESYVSF--------------S 958
            LE    Y A        TFHP          N+GL  G   YV F              S
Sbjct: 1180 LEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPG-HRYVLFVLAVLQKSEPTFAAS 1238

Query: 959  RYSDAVSL--PQDPGVICGA-----VFGCIFGALVIVTVGGFIFWRKKRKDAKN------ 1005
             +SD   L  P    ++ G      V G +   + I+ +   I   K + D+K       
Sbjct: 1239 PFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPR 1298

Query: 1006 -----NEVSFSQIKPKKSKLIRVENFEA----------------YFKKQQADSNCGFAEE 1044
                 N    +   PK    +R  NF+                 + ++ +A+ +   ++E
Sbjct: 1299 TKCLLNNADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQE 1358

Query: 1045 YEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLS-VQTHSTDDYINANYMPGY 1103
            YE +   G       + L  N+ KNRY NV+ YD SRV L  ++     DYINANY+ GY
Sbjct: 1359 YESID-PGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGY 1417

Query: 1104 HSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYGD 1163
              +  +IATQGPLP T  DFWRMVWE+    I+M+T+  E+ R KC++YWP++  + YG 
Sbjct: 1418 RCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGF 1477

Query: 1164 ITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVR 1223
            I V +   I L  + +R F++    +SE   +RQF FT+WPDHGVP+     + F   +R
Sbjct: 1478 IQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAF---LR 1534

Query: 1224 DYMKQSPPES-PILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMV 1282
                 +PP++ PI+VHCSAGVGRTG FI ID ++ +I+ E TVDVYG V  +R  R  MV
Sbjct: 1535 RVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMV 1594

Query: 1283 QTEDQYVFLNQCVLDIV 1299
            QTEDQY F+++ +L+ V
Sbjct: 1595 QTEDQYSFIHEALLEAV 1611



 Score =  210 bits (534), Expect = 8e-54
 Identities = 104/244 (42%), Positives = 152/244 (62%), Gaps = 1/244 (0%)

Query: 1059 AAELAENRGKNRYNNVLPYDISRVKLS-VQTHSTDDYINANYMPGYHSKKDFIATQGPLP 1117
            +A L  N+ KNR  N++PY+ +RV L  ++     DYINA+++ GY  +K +IATQGPL 
Sbjct: 1661 SANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLA 1720

Query: 1118 NTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEW 1177
             T +DFWRM+WE N   ++MLTK  E GR KC +YWP++++  Y    V   +E  +P++
Sbjct: 1721 ETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQY 1780

Query: 1178 TIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILV 1237
             +R+F V + +  +S  +RQF FT WP+ GVP + +  I+F   V    +Q   + PI V
Sbjct: 1781 ILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISV 1840

Query: 1238 HCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLD 1297
            HCSAGVGRTG FI +  ++ ++  E  VD++  V  LR  RP MVQTED+Y F  Q  L+
Sbjct: 1841 HCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALE 1900

Query: 1298 IVRS 1301
             + S
Sbjct: 1901 YLGS 1904



 Score = 48.5 bits (114), Expect = 4e-05
 Identities = 107/472 (22%), Positives = 176/472 (37%), Gaps = 62/472 (13%)

Query: 328 TEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTN----AIQVFDVTAVNISATSLT 383
           T   + GL P + Y   V +  + G     +++  RT     A    +V A  +SAT++ 
Sbjct: 372 TRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMI 431

Query: 384 LIWKVSDNESSSNYTYKI-------HVAGETDSSNLNVSEPRAVIPGLRSSTFYNITVCP 436
           + W+     +     Y++       H  G     N++ S    V   L   T Y + V  
Sbjct: 432 VQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDET-YTVRVLA 490

Query: 437 VLGDIEGTPGF-LQVHTP---PVPVSDFRVTVVSTTEIGLAWSSHDAESFQMH--ITQEG 490
                +G     +QV T    P    + R    S T I L+WS    ES   +  + +EG
Sbjct: 491 FTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREG 550

Query: 491 AGNSRVEITTNQ--SIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTV---PSA-VF 544
                V  T +   S ++  L P T+Y F +  + P G    +  V  RT+   PSA   
Sbjct: 551 DHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQ 610

Query: 545 DIHVVYVTTTEMWLDWKSPDGASE---YVYHLVIESKHGS--------NHTSTYDKAITL 593
           D+  V V +T + + W+ P   +     V + V     GS        N        I L
Sbjct: 611 DVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILL 670

Query: 594 QGLIPGTLYNITISPEVDHVWGDPNSTAQYTRPSNVSNID------VSTNTTAATLSWQN 647
           + L   T Y IT     +   G  +S        +V +         + N TA  + W++
Sbjct: 671 EALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRS 730

Query: 648 FDDASPTYSYCLL-------IEKAGNSSNATQVVTDIGITDA---TVTELIPGSSY--TV 695
               +P   +  +       +   G  +     + D+ + DA    +T L P ++Y  TV
Sbjct: 731 ---PAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQEMVITNLQPETAYSITV 787

Query: 696 EIFAQVGDGIKSLEPGRKSFCTDPASMA--SFDCEVVPKEPALVLKWTCPPG 745
             +   GDG +S     K   T  A +   +   +  P E +L+ +W  P G
Sbjct: 788 AAYTMKGDGARSKP---KVVVTKGAVLGRPTLSVQQTP-EGSLLARWEPPAG 835



 Score = 44.3 bits (103), Expect = 8e-04
 Identities = 46/197 (23%), Positives = 77/197 (39%), Gaps = 39/197 (19%)

Query: 305  TAPVHDESLVGPVD----PSSGQQSRDTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAI 360
            T  V +   +GP      P++ +   +  + L GL+P T Y+  V +    G       +
Sbjct: 944  TVAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPV 1003

Query: 361  EFRT---NAIQVFDVTAVNISATSLTLIWKVSDNESSSNYTYKIHVAGETDSSNLNVSEP 417
             +RT   + +   +     I  TS+ L W+  DN +S    YKI   G T   +++    
Sbjct: 1004 RYRTFLRDQVSPKNFKVKMIMKTSVLLSWEFPDNYNSPT-PYKIQYNGLT--LDVDGRTT 1060

Query: 418  RAVIPGLRSSTFYN----------------ITVCPVLGDIEGTP---------GFLQVHT 452
            + +I  L+  TFYN                +T       + G P         GF+ V+ 
Sbjct: 1061 KKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYL 1120

Query: 453  P----PVPVSDFRVTVV 465
            P    PVPV  + + +V
Sbjct: 1121 PDGQSPVPVQSYFIVMV 1137



 Score = 31.2 bits (69), Expect = 7.0
 Identities = 97/474 (20%), Positives = 170/474 (35%), Gaps = 82/474 (17%)

Query: 36  AGGTPSPIPDPSVATVATGENGITQ-ISSTAESFHKQNGTGTPQVE-----TNTSEDGES 89
           A GTP    + + +   T ++G    +S     +  ++  G  Q++     T  S  G S
Sbjct: 321 APGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLS 380

Query: 90  SGANDSLRTPEQGSNGTDGASQKTPSSTGP----SPVFDIKAVSISPTNVILTWKSNDTA 145
             +   +      S G    S+   + TG     S   +++A  +S T +I+ W+     
Sbjct: 381 PNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEP 440

Query: 146 ASEYK-YVVKHKMENEKTI------TVVHQPWCNITGLRPATSYVFSITP--GIGNETWG 196
               + Y V + ME E  +       V       +  L    +Y   +     +G+    
Sbjct: 441 NGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLS 500

Query: 197 DPRVIKVITE---PIPVSDLRVALTGVRKAALSWSNGNGTASCRV-LLESIGSHEE---L 249
           DP  I+V T+   P    +LR          LSWS     +  +  LL   G H      
Sbjct: 501 DP--IQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGREVGR 558

Query: 250 TQDSRLQVNISGLKPGVQYNINPYLLQSNKTKGDPLGTEGGLDASNTERSRAGSPTAPV- 308
           T D      +  LKP  +Y    + L +   +G  LG    +    T +S+  +P   V 
Sbjct: 559 TFDPTTSYVVEDLKPNTEY---AFRLAARSPQG--LGAFTPVVRQRTLQSKPSAPPQDVK 613

Query: 309 --------------------HDESLVG---------PVDPS----SGQQSRDTEVLLVGL 335
                               H+ +LVG           DP     +G     T++LL  L
Sbjct: 614 CVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEAL 673

Query: 336 EPGTRYNATVYSQAANGTEGQPQAIEFRTN----AIQVFDVTAVNISATSLTLIWK--VS 389
           E  T+Y  T  +    G   +   +  RT+    +     V A  ++AT++ ++W+    
Sbjct: 674 EKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAP 733

Query: 390 DNESSSNYTYKIH--------VAGETDSSNLNVSEPR-AVIPGLRSSTFYNITV 434
             +      Y++H          G     ++ +++ +  VI  L+  T Y+ITV
Sbjct: 734 GRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQEMVITNLQPETAYSITV 787


>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform 2
            precursor [Homo sapiens]
          Length = 1898

 Score =  239 bits (611), Expect = 1e-62
 Identities = 320/1321 (24%), Positives = 534/1321 (40%), Gaps = 184/1321 (13%)

Query: 119  PSPVFDIKAVSISPTNVILTWKSNDTAASEYKYVVKHKMENEK----TITVVHQPWCNIT 174
            P P  D+     + T+V LTW S ++    Y Y ++++    +     +  V     +I 
Sbjct: 319  PKPPIDLVVTETTATSVTLTWDSGNSEPVTY-YGIQYRAAGTEGPFQEVDGVATTRYSIG 377

Query: 175  GLRPATSYVFSITPGIGNETWGDP-RVIKVIT-EPIPVSDLRVALTGVRKAA---LSWS- 228
            GL P + Y F +   + +   G P   ++  T E  P S  R     +  A+   + W  
Sbjct: 378  GLSPFSEYAFRVL-AVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEP 436

Query: 229  --NGNGTASCRVLLESIGS-------HEELTQDSRLQVNISGLKPGVQYNINPYLLQSNK 279
                NG      +  +  S       H+  T D+ L   +  L PG+ Y++   L  +  
Sbjct: 437  PEEPNGLVRGYRVYYTPDSRRPPNAWHKHNT-DAGLLTTVGSLLPGITYSLR-VLAFTAV 494

Query: 280  TKGDP-----LGTEGGLDASNTERSRAGSPTAPVHDESLVGPVD------------PSSG 322
              G P     + T+ G+ A   +          +    L+ P +                
Sbjct: 495  GDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERIIMYELVYWAAEDED 554

Query: 323  QQSRDT-----EVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTN----AIQVFDVT 373
            QQ + T        L  L+P T Y   + +++  G       IE RT     +     V 
Sbjct: 555  QQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVM 614

Query: 374  AVNISATSLTLIWKVSDNESSSNYTYKIHVA-----GETDSSNL--NVSEPRAV--IPGL 424
             V++ +T++ + W     +S +    +  VA     GE    ++   +S   +   + GL
Sbjct: 615  CVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGL 674

Query: 425  RSSTFYNITV---CPVLGDIEGTPGFLQVH--TPPVPVSDFRVTVVSTTEIGLAWS---- 475
               T Y + V     V    E +P  ++     P  P     V  +++T + + W     
Sbjct: 675  EKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVP 734

Query: 476  ---SHDAESFQMHITQEGAGNSR-------VEITTNQSIIIGGLFPGTKYCFEIVPKGPN 525
                     +Q+   +   G  R       V +   Q   I GL P T Y   +      
Sbjct: 735  SKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQETTISGLTPETTYSVTVAAYTTK 794

Query: 526  GTEGASRTVCNRTVPSAVFDIHVVYVTTTEM---WLDWKSPDGASEYV------YHLVIE 576
            G +GA       T   AV     + ++TT M    L W  P      +      Y    E
Sbjct: 795  G-DGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQWHPPKELPGELLGYRLQYCRADE 853

Query: 577  SKHGSNHTSTYDKAITLQGLIPGTLYNITISPEVDHVWGDPNSTAQYTR---PSNV-SNI 632
            ++  +      D+  T+ GL  GT Y   ++ +     G+       T    PS    N+
Sbjct: 854  ARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNL 913

Query: 633  DVSTNTTAAT-LSWQN---FDDASPTYSYCLLIEKAGNSSNATQVVTDIGITDATVTELI 688
             V+  TT+ T L+W      +      SY ++     +      + TD   T  T+T L 
Sbjct: 914  HVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQELQNITTD---TRFTLTGLK 970

Query: 689  PGSSYTVEIFAQVGDGIKSLEPGRKSFCTDPASMASFDCEVVPK-EPALVLKWTCPPGAN 747
            P ++Y +++ A    G   L P  +S       + + +  V    + +++L W  P    
Sbjct: 971  PDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMKTSVLLSWEVPDSYK 1030

Query: 748  AGFELEVSSGAWNNATHLESCSSENGTEYRTEVTYLNFSTSYNISITTVSCGKMAAPTRN 807
            +    ++      N   +E     +G   R  +  L  +T Y  S   ++ G  A   ++
Sbjct: 1031 SAVPFKILY----NGQSVEV----DGHSMRKLIADLQPNTEY--SFVLMNRGSSAGGLQH 1080

Query: 808  -----TCTTGITDPPPP------DGSPNITSVSHNSVKVKFSGFEASHGPIKAYAVILTT 856
                 T    +   P P      DG  ++ S+ H         F     PI      + T
Sbjct: 1081 LVSIRTAPDLLPHKPLPASAYIEDGRFDL-SMPHVQDPSLVRWFYIVVVPIDRVGGSMLT 1139

Query: 857  GEAGHPSADVLKYTYEDFKKGASDTYVTYLIRTEEKGRSQSLSEVLKYEIDVGNESTTLG 916
                 P    L    E  ++G  +       +   + +++ L   +  ++DV  E+ TLG
Sbjct: 1140 PRWSTPEELELDELLEAIEQGGEE-------QRRRRRQAERLKPYVAAQLDVLPETFTLG 1192

Query: 917  -------YYNGKLEPLGSYRACVAGFTNITFHPQNKGLIDGAESYVSFSRYSDAVSLPQD 969
                   +YN  L P  SY+  V         P ++      + Y S S YSD + +   
Sbjct: 1193 DKKNYRGFYNRPLSPDLSYQCFVLASLK---EPMDQ------KRYAS-SPYSDEIVVQVT 1242

Query: 970  PGV---------ICGAVFGCIFGALVIVTVGGFIFWRKKR-----KDA-----KNNEVSF 1010
            P           + G V   I   L+++ +   +F RK+      KD      K++ ++ 
Sbjct: 1243 PAQQQEEPEMLWVTGPVLAVILIILIVIAI--LLFKRKRTHSPSSKDEQSIGLKDSLLAH 1300

Query: 1011 SQIKPKKSKL------------IRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQPKY 1058
            S    +  +L            I + +     ++ +A+    F++EYE +   G      
Sbjct: 1301 SSDPVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESID-PGQQFTWE 1359

Query: 1059 AAELAENRGKNRYNNVLPYDISRVKL-SVQTHSTDDYINANYMPGYHSKKDFIATQGPLP 1117
             + L  N+ KNRY NV+ YD SRV L S+      DYINANY+ GY  +  +IATQGPLP
Sbjct: 1360 NSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLP 1419

Query: 1118 NTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEW 1177
             T+ DFWRMVWE+    ++M+T+  E+ R KC++YWP++  +  G I V +   + L  +
Sbjct: 1420 ETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATY 1479

Query: 1178 TIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPES-PIL 1236
            T+R F +    +SE   LRQF F +WPDHGVP+    ++ F   +R     +P ++ P++
Sbjct: 1480 TVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAF---LRRVKACNPLDAGPMV 1536

Query: 1237 VHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVL 1296
            VHCSAGVGRTG FI ID ++ ++++E TVD+YG V  +R  R  MVQTEDQYVF+++ +L
Sbjct: 1537 VHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALL 1596

Query: 1297 D 1297
            +
Sbjct: 1597 E 1597



 Score =  210 bits (534), Expect = 8e-54
 Identities = 104/244 (42%), Positives = 152/244 (62%), Gaps = 1/244 (0%)

Query: 1059 AAELAENRGKNRYNNVLPYDISRVKLS-VQTHSTDDYINANYMPGYHSKKDFIATQGPLP 1117
            +A L  N+ KNR  N++PY+++RV L  ++     DYINA+++ GY  +K +IATQGPL 
Sbjct: 1649 SANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLA 1708

Query: 1118 NTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEW 1177
             + +DFWRM+WE N   I+MLTK  E GR KC +YWP++++  Y    V   +E  +P++
Sbjct: 1709 ESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQY 1768

Query: 1178 TIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILV 1237
             +R+F V + +  +S  +RQF FT WP+ GVP T +  I+F   V    +Q   + PI V
Sbjct: 1769 ILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITV 1828

Query: 1238 HCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLD 1297
            HCSAGVGRTG FI +  ++ ++  E  VD++  V  LR  RP MVQTEDQY    +  L+
Sbjct: 1829 HCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALE 1888

Query: 1298 IVRS 1301
             + S
Sbjct: 1889 YLGS 1892



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 105/478 (21%), Positives = 166/478 (34%), Gaps = 56/478 (11%)

Query: 427 STFYNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDAESFQMH- 485
           S  Y       LG IE T   + V   P P  D  VT  + T + L W S ++E    + 
Sbjct: 293 SANYTCVAISSLGMIEATAQ-VTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYG 351

Query: 486 ITQEGAGN----SRVEITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTVPS 541
           I    AG       V+        IGGL P ++Y F ++     G    S  V  RT   
Sbjct: 352 IQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQ 411

Query: 542 AVFD----IHVVYVTTTEMWLDWKSPDGAS----EYVYHLVIESKHGSN----HTSTYDK 589
           A       +    ++ + M + W+ P+  +     Y  +   +S+   N    H +    
Sbjct: 412 APSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGL 471

Query: 590 AITLQGLIPGTLYNITISPEVDHVWGDPNSTAQYTR----PSNVSNIDVSTNT-TAATLS 644
             T+  L+PG  Y++ +        G P+ T Q       P+  ++      + T   LS
Sbjct: 472 LTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLS 531

Query: 645 WQNFDDASPTYSYCLLIEK---AGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQV 701
           W       P     ++ E    A    +    VT    +  T+ +L P + Y  ++ A+ 
Sbjct: 532 W-----LLPPQERIIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARS 586

Query: 702 GDGIKSLEP---GRKSFCTDPASMASFDCEVVPKEPALVLKWTCPPGANAGFELEVSSGA 758
             G+    P    R +  T  A      C V      + + W  PP  +    +   S A
Sbjct: 587 DMGVGVFTPTIEARTAQSTPSAPPQKVMC-VSMGSTTVRVSWVPPPADSRNGVITQYSVA 645

Query: 759 W------NNATHLESCSSENGTEYRTEVTYLNFSTSYNISI---TTVSCGKMAAPTRNTC 809
           +      +   H+    S   + +  ++  L   T Y + +   T V  G  ++P     
Sbjct: 646 YEAVDGEDRGRHVVDGISREHSSW--DLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVR- 702

Query: 810 TTGITDPPPPDGSPNITSVSH-NSVKV----KFSGFEASHGPIKAYAVILTTGEAGHP 862
               TD   P G P    V   NS  V    K       HG I+ Y V     E G P
Sbjct: 703 ----TDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEP 756


>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform 1
            precursor [Homo sapiens]
          Length = 1907

 Score =  238 bits (608), Expect = 2e-62
 Identities = 235/872 (26%), Positives = 380/872 (43%), Gaps = 107/872 (12%)

Query: 495  RVEITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTVPSAVFDIHVVYVTTT 554
            R E + +    I GL P T Y   +      G +GA       T   AV     + ++TT
Sbjct: 773  RPEESEDYETTISGLTPETTYSVTVAAYTTKG-DGARSKPKIVTTTGAVPGRPTMMISTT 831

Query: 555  EM---WLDWKSPDGASEYV------YHLVIESKHGSNHTSTYDKAITLQGLIPGTLYNIT 605
             M    L W  P      +      Y    E++  +      D+  T+ GL  GT Y   
Sbjct: 832  AMNTALLQWHPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFR 891

Query: 606  ISPEVDHVWGDPNSTAQYTR---PSNV-SNIDVSTNTTAAT-LSWQN---FDDASPTYSY 657
            ++ +     G+       T    PS    N+ V+  TT+ T L+W      +      SY
Sbjct: 892  LAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISY 951

Query: 658  CLLIEKAGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQVGDGIKSLEPGRKSFCT 717
             ++     +      + TD   T  T+T L P ++Y +++ A    G   L P  +S   
Sbjct: 952  TVVFRDINSQQELQNITTD---TRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTM 1008

Query: 718  DPASMASFDCEVVPK-EPALVLKWTCPPGANAGFELEVSSGAWNNATHLESCSSENGTEY 776
                + + +  V    + +++L W  P    +    ++      N   +E     +G   
Sbjct: 1009 PVEQVFAKNFRVAAAMKTSVLLSWEVPDSYKSAVPFKILY----NGQSVEV----DGHSM 1060

Query: 777  RTEVTYLNFSTSYNISITTVSCGKMAAPTRN-----TCTTGITDPPPP------DGSPNI 825
            R  +  L  +T Y  S   ++ G  A   ++     T    +   P P      DG  ++
Sbjct: 1061 RKLIADLQPNTEY--SFVLMNRGSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDL 1118

Query: 826  TSVSHNSVKVKFSGFEASHGPIKAYAVILTTGEAGHPSADVLKYTYEDFKKGASDTYVTY 885
             S+ H         F     PI      + T     P    L    E  ++G  +     
Sbjct: 1119 -SMPHVQDPSLVRWFYIVVVPIDRVGGSMLTPRWSTPEELELDELLEAIEQGGEE----- 1172

Query: 886  LIRTEEKGRSQSLSEVLKYEIDVGNESTTLG-------YYNGKLEPLGSYRACVAGFTNI 938
              +   + +++ L   +  ++DV  E+ TLG       +YN  L P  SY+  V      
Sbjct: 1173 --QRRRRRQAERLKPYVAAQLDVLPETFTLGDKKNYRGFYNRPLSPDLSYQCFVLASLK- 1229

Query: 939  TFHPQNKGLIDGAESYVSFSRYSDAVSLPQDPGV---------ICGAVFGCIFGALVIVT 989
               P ++      + Y S S YSD + +   P           + G V   I   L+++ 
Sbjct: 1230 --EPMDQ------KRYAS-SPYSDEIVVQVTPAQQQEEPEMLWVTGPVLAVILIILIVIA 1280

Query: 990  VGGFIFWRKKR-----KDA-----KNNEVSFSQIKPKKSKL------------IRVENFE 1027
            +   +F RK+      KD      K++ ++ S    +  +L            I + +  
Sbjct: 1281 I--LLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMRDHPPIPITDLA 1338

Query: 1028 AYFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKL-SV 1086
               ++ +A+    F++EYE +   G       + L  N+ KNRY NV+ YD SRV L S+
Sbjct: 1339 DNIERLKANDGLKFSQEYESID-PGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSI 1397

Query: 1087 QTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGR 1146
                  DYINANY+ GY  +  +IATQGPLP T+ DFWRMVWE+    ++M+T+  E+ R
Sbjct: 1398 DGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSR 1457

Query: 1147 TKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDH 1206
             KC++YWP++  +  G I V +   + L  +T+R F +    +SE   LRQF F +WPDH
Sbjct: 1458 VKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDH 1517

Query: 1207 GVPDTTDLLINFRYLVRDYMKQSPPES-PILVHCSAGVGRTGTFIAIDRLIYQIENENTV 1265
            GVP+    ++ F   +R     +P ++ P++VHCSAGVGRTG FI ID ++ ++++E TV
Sbjct: 1518 GVPEYPTPILAF---LRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTV 1574

Query: 1266 DVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLD 1297
            D+YG V  +R  R  MVQTEDQYVF+++ +L+
Sbjct: 1575 DIYGHVTCMRSQRNYMVQTEDQYVFIHEALLE 1606



 Score =  210 bits (534), Expect = 8e-54
 Identities = 104/244 (42%), Positives = 152/244 (62%), Gaps = 1/244 (0%)

Query: 1059 AAELAENRGKNRYNNVLPYDISRVKLS-VQTHSTDDYINANYMPGYHSKKDFIATQGPLP 1117
            +A L  N+ KNR  N++PY+++RV L  ++     DYINA+++ GY  +K +IATQGPL 
Sbjct: 1658 SANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLA 1717

Query: 1118 NTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEW 1177
             + +DFWRM+WE N   I+MLTK  E GR KC +YWP++++  Y    V   +E  +P++
Sbjct: 1718 ESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQY 1777

Query: 1178 TIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILV 1237
             +R+F V + +  +S  +RQF FT WP+ GVP T +  I+F   V    +Q   + PI V
Sbjct: 1778 ILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITV 1837

Query: 1238 HCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLD 1297
            HCSAGVGRTG FI +  ++ ++  E  VD++  V  LR  RP MVQTEDQY    +  L+
Sbjct: 1838 HCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALE 1897

Query: 1298 IVRS 1301
             + S
Sbjct: 1898 YLGS 1901



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 105/478 (21%), Positives = 166/478 (34%), Gaps = 56/478 (11%)

Query: 427 STFYNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDAESFQMH- 485
           S  Y       LG IE T   + V   P P  D  VT  + T + L W S ++E    + 
Sbjct: 293 SANYTCVAISSLGMIEATAQ-VTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYG 351

Query: 486 ITQEGAGN----SRVEITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTVPS 541
           I    AG       V+        IGGL P ++Y F ++     G    S  V  RT   
Sbjct: 352 IQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQ 411

Query: 542 AVFD----IHVVYVTTTEMWLDWKSPDGAS----EYVYHLVIESKHGSN----HTSTYDK 589
           A       +    ++ + M + W+ P+  +     Y  +   +S+   N    H +    
Sbjct: 412 APSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGL 471

Query: 590 AITLQGLIPGTLYNITISPEVDHVWGDPNSTAQYTR----PSNVSNIDVSTNT-TAATLS 644
             T+  L+PG  Y++ +        G P+ T Q       P+  ++      + T   LS
Sbjct: 472 LTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLS 531

Query: 645 WQNFDDASPTYSYCLLIEK---AGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQV 701
           W       P     ++ E    A    +    VT    +  T+ +L P + Y  ++ A+ 
Sbjct: 532 W-----LLPPQERIIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARS 586

Query: 702 GDGIKSLEP---GRKSFCTDPASMASFDCEVVPKEPALVLKWTCPPGANAGFELEVSSGA 758
             G+    P    R +  T  A      C V      + + W  PP  +    +   S A
Sbjct: 587 DMGVGVFTPTIEARTAQSTPSAPPQKVMC-VSMGSTTVRVSWVPPPADSRNGVITQYSVA 645

Query: 759 W------NNATHLESCSSENGTEYRTEVTYLNFSTSYNISI---TTVSCGKMAAPTRNTC 809
           +      +   H+    S   + +  ++  L   T Y + +   T V  G  ++P     
Sbjct: 646 YEAVDGEDRGRHVVDGISREHSSW--DLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVR- 702

Query: 810 TTGITDPPPPDGSPNITSVSH-NSVKV----KFSGFEASHGPIKAYAVILTTGEAGHP 862
               TD   P G P    V   NS  V    K       HG I+ Y V     E G P
Sbjct: 703 ----TDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEP 756



 Score = 50.4 bits (119), Expect = 1e-05
 Identities = 128/601 (21%), Positives = 219/601 (36%), Gaps = 81/601 (13%)

Query: 371 DVTAVNISATSLTLIWKVSDNESSSNYTYKIHVAG------ETDSSNLNVSEPRAVIPGL 424
           D+     +ATS+TL W   ++E  + Y  +   AG      E D     V+  R  I GL
Sbjct: 324 DLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTEGPFQEVD----GVATTRYSIGGL 379

Query: 425 RSSTFYNITVCPVLGDIEGTPG-FLQVHT----PPVPVSDFRVTVVSTTEIGLAWSSHD- 478
              + Y   V  V     G P   ++  T    P  P    +  ++S + + + W   + 
Sbjct: 380 SPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEE 439

Query: 479 ----AESFQMHITQEG--AGNSRVEITTNQSII--IGGLFPGTKYCFEIVPKGPNGTEGA 530
                  ++++ T +     N+  +  T+  ++  +G L PG  Y   ++     G    
Sbjct: 440 PNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPP 499

Query: 531 SRTVCNRT---VPSAVFDIHVVYVTTTEMWLDWKSPDGASEYVYHLV--IESKHGSNHTS 585
           S T+  +T   VP+   D      + T + L W  P      +Y LV          H  
Sbjct: 500 SPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERIIMYELVYWAAEDEDQQHKV 559

Query: 586 TYD--KAITLQGLIPGTLYNITISPEVDHVWG--DPN---STAQYTRPSNVSNI-DVSTN 637
           T+D   + TL+ L P TLY   ++   D   G   P     TAQ T  +    +  VS  
Sbjct: 560 TFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMG 619

Query: 638 TTAATLSW--QNFDDASPTYS-YCLLIEKAGNSSNATQVVTDIGITDATVTELIPGSSYT 694
           +T   +SW     D  +   + Y +  E          VV  I   + +  +L+    +T
Sbjct: 620 STTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGIS-REHSSWDLVGLEKWT 678

Query: 695 -----VEIFAQVGDGIKSLEPGRKSFCTDPASMASFDCEVVP-KEPALVLKWTCP----- 743
                V     VG G +S  P       D  S      EV P    A+ + W  P     
Sbjct: 679 EYRVWVRAHTDVGPGPES-SPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQ 737

Query: 744 PGANAGFE---LEVSSGAWNNATHLESC-------SSENGTEYRTEVTYLNFSTSYNISI 793
            G   G++   + + +G       ++           E   +Y T ++ L   T+Y++++
Sbjct: 738 HGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDYETTISGLTPETTYSVTV 797

Query: 794 ---TTVSCGKMAAPTRNTCTTGITDPPPPDGSPNITSVSHNSVKVKFSGFEASHGPIKAY 850
              TT   G  + P   T T  +   P    +  I++ + N+  +++   +   G +  Y
Sbjct: 798 AAYTTKGDGARSKPKIVTTTGAVPGRP----TMMISTTAMNTALLQWHPPKELPGELLGY 853

Query: 851 AVILTTGEAGHPSA-----DVLKYTYEDFKKGASDTYVTYLIRTEEKGRSQSLSEVLKYE 905
            +     +   P+      D   +T     KG      TY+ R   K R+  L E  + E
Sbjct: 854 RLQYCRADEARPNTIDFGKDDQHFTVTGLHKG-----TTYIFRLAAKNRA-GLGEEFEKE 907

Query: 906 I 906
           I
Sbjct: 908 I 908



 Score = 45.1 bits (105), Expect = 5e-04
 Identities = 56/263 (21%), Positives = 100/263 (38%), Gaps = 22/263 (8%)

Query: 323  QQSRDTEVLLVGLEPGTRYNATV--YSQAANGTEGQPQAIEFRTNAIQVFDVTAVNISAT 380
            ++S D E  + GL P T Y+ TV  Y+   +G   +P+ +   T A+       ++ +A 
Sbjct: 775  EESEDYETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVT-TTGAVPGRPTMMISTTAM 833

Query: 381  SLTLI-WKVSDNESSSNYTYKIHVA----GETDSSNLNVSEPRAVIPGLRSSTFYNITVC 435
            +  L+ W            Y++          ++ +    +    + GL   T Y   + 
Sbjct: 834  NTALLQWHPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLA 893

Query: 436  PVLGDIEGTPGFLQVHTPPVPVSDF----RVTVVSTTEIGLAWS-------SHDAESFQM 484
                   G     ++ TP    S F     VT ++T+   LAW        +    S+ +
Sbjct: 894  AKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTV 953

Query: 485  HITQEGAGNSRVEITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTVP-SAV 543
                  +      ITT+    + GL P T Y  ++      G+   S ++ +RT+P   V
Sbjct: 954  VFRDINSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQV 1013

Query: 544  F--DIHVVYVTTTEMWLDWKSPD 564
            F  +  V     T + L W+ PD
Sbjct: 1014 FAKNFRVAAAMKTSVLLSWEVPD 1036



 Score = 39.3 bits (90), Expect = 0.026
 Identities = 33/131 (25%), Positives = 59/131 (45%), Gaps = 6/131 (4%)

Query: 327  DTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQVFDVTAVNISA---TSLT 383
            DT   L GL+P T Y+  V +  + G+     +I+ RT  ++        ++A   TS+ 
Sbjct: 970  DTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMKTSVL 1029

Query: 384  LIWKVSDNESSSNYTYKIHVAGETDSSNLNVSEPRAVIPGLRSSTFYNITVCPVLGDIEG 443
            L W+V D+  S+   +KI   G+  S  ++    R +I  L+ +T Y+  +        G
Sbjct: 1030 LSWEVPDSYKSA-VPFKILYNGQ--SVEVDGHSMRKLIADLQPNTEYSFVLMNRGSSAGG 1086

Query: 444  TPGFLQVHTPP 454
                + + T P
Sbjct: 1087 LQHLVSIRTAP 1097



 Score = 35.8 bits (81), Expect = 0.28
 Identities = 67/299 (22%), Positives = 100/299 (33%), Gaps = 33/299 (11%)

Query: 421  IPGLRSSTFYNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWSS-HDA 479
            I GL   T Y++TV       +G     ++ T    V      ++STT +  A    H  
Sbjct: 784  ISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQWHPP 843

Query: 480  ESFQMHI---------TQEGAGNSRVEITTNQSIIIGGLFPGTKYCFEIVPKGPNGT--E 528
            +     +           E   N+      +Q   + GL  GT Y F +  K   G   E
Sbjct: 844  KELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEE 903

Query: 529  GASRTVCNRTVPSAV-FDIHVVYVTTTEMWLDWKSPDGASE----YVYHLVIESKHGSNH 583
                      +PS    ++HV  +TT+   L W  P  A        Y +V    +    
Sbjct: 904  FEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQE 963

Query: 584  TS--TYDKAITLQGLIPGTLYNITISPEVDHVWGDPNSTAQYTRPSNVSNIDVSTNTTAA 641
                T D   TL GL P T Y+I +        G P S +  +R   V  +       AA
Sbjct: 964  LQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSG-PLSPSIQSRTMPVEQVFAKNFRVAA 1022

Query: 642  T------LSWQNFDDASPTYSYCLLIEKAGNSSNATQVVTDIGITDATVTELIPGSSYT 694
                   LSW+  D       + +L        N   V  D       + +L P + Y+
Sbjct: 1023 AMKTSVLLSWEVPDSYKSAVPFKILY-------NGQSVEVDGHSMRKLIADLQPNTEYS 1074


>gi|104487006 protein tyrosine phosphatase, receptor type, sigma
            isoform 1 precursor [Homo sapiens]
          Length = 1948

 Score =  233 bits (594), Expect = 9e-61
 Identities = 276/1122 (24%), Positives = 448/1122 (39%), Gaps = 199/1122 (17%)

Query: 328  TEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRT----NAIQVFDVTAVNISATSLT 383
            T  ++  L+P T Y   + +++  G       +  RT     +    DV  V++ +T++ 
Sbjct: 577  TSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAIL 636

Query: 384  LIWKVSDNESSSN----YTYKIHVAGETDSSNLNVS-----EPRAVIPGLRSSTFYNITV 434
            + W+    E+ +     Y+ +    G  D     V+       + ++  L   T Y IT 
Sbjct: 637  VSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITT 696

Query: 435  CP---VLGDIEGTPGFLQVH--TPPVPVSDFRVTVVSTTEIGLAWSSH-------DAESF 482
                 V    E +P  ++     P  P        ++ T I + W S            +
Sbjct: 697  VAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGY 756

Query: 483  QMH-ITQEGA---GNSRV------------EITTNQSIIIGGLFPGTKYCFEIVP---KG 523
            Q+H +  EGA   G  R+            + T    ++I  L P T Y   +     KG
Sbjct: 757  QVHYVRMEGAEARGPPRIKDVMLADAQWETDDTAEYEMVITNLQPETAYSITVAAYTMKG 816

Query: 524  PNGTEGASRTVCNRTVPSAVFDIHVVYVTTTEMWLDWKSPDGASE---YVYHLVIESKHG 580
             +G     + V  +        + V       +   W+ P G +E     Y L    +  
Sbjct: 817  -DGARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLARWEPPAGTAEDQVLGYRLQF-GRED 874

Query: 581  SNHTSTYD-----KAITLQGLIPGTLYNITISPEVDHVWGDPN----STAQYTRPSNVSN 631
            S   +T +        T  G+  G  Y   ++       G+      S  + T   +   
Sbjct: 875  STPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEEAAEVLSIPEDTPRGHPQI 934

Query: 632  IDVSTNTTAAT--LSWQNFDDASPT---YSYCLLIEKAGNSSNATQV----VTDIGITDA 682
            ++ + N +A T  L W     A        Y + + +AG    A +       + G  +A
Sbjct: 935  LEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGALGPARETELPAAAEPGAENA 994

Query: 683  -TVTELIPGSSYTVEIFAQVGDGIKSLEPG--RKSFCTDPASMASFDCEVVPKEPALVLK 739
             T+  L P ++Y +++ A    G     P    ++F  D  S  +F  +++ K   L L 
Sbjct: 995  LTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRTFLRDQVSPKNFKVKMIMKTSVL-LS 1053

Query: 740  WTCPPGANAGFELEVSSGAWNNATHLESCSSENGTEYRTEVTYLNFSTSYNISITTVSCG 799
            W  P   N+    ++    +N  T        +G   +  +T+L   T YN  +T  + G
Sbjct: 1054 WEFPDNYNSPTPYKIQ---YNGLT-----LDVDGRTTKKLITHLKPHTFYNFVLT--NRG 1103

Query: 800  KMAAPTRNTCTTGITDPPPPDGSPNITSVSHNSVKVKFSGF-------EASHGPIKAYAV 852
                  + T T   T     +G P++        K    GF         S  P+++Y +
Sbjct: 1104 SSLGGLQQTVTAW-TAFNLLNGKPSVAP------KPDADGFIMVYLPDGQSPVPVQSYFI 1156

Query: 853  ILTTGEAGHPSADVLKYTYEDFKKGASDTYVTYLIRTEEKGRSQSLSEVLKYEIDVGNES 912
            ++                    +K     ++T L   E+      L E+++   D+    
Sbjct: 1157 VMVP-----------------LRKSRGGQFLTPLGSPED----MDLEELIQ---DISRLQ 1192

Query: 913  TTLGYYNGKLEPLGSYRACVAGFTNITFHP---------QNKGLIDGAESYVSF------ 957
                 ++ +LE    Y A        TFHP          N+GL  G   YV F      
Sbjct: 1193 RRSLRHSRQLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPG-HRYVLFVLAVLQ 1251

Query: 958  --------SRYSDAVSL--PQDPGVICGA-----VFGCIFGALVIVTVGGFIFWRKKRKD 1002
                    S +SD   L  P    ++ G      V G +   + I+ +   I   K + D
Sbjct: 1252 KSEPTFAASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPD 1311

Query: 1003 AKN-----------NEVSFSQIKPKKSKLIRVENFEA----------------------- 1028
            +K            N    +   PK    +R  NF+                        
Sbjct: 1312 SKRKDSEPRTKCLLNNADLAPHHPKDPVEMRRINFQTPDSGLRSPLREPGFHFESMLSHP 1371

Query: 1029 ---------YFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDI 1079
                     + ++ +A+ +   ++EYE +   G       + L  N+ KNRY NV+ YD 
Sbjct: 1372 PIPIADMAEHTERLKANDSLKLSQEYESID-PGQQFTWEHSNLEVNKPKNRYANVIAYDH 1430

Query: 1080 SRVKLS-VQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIML 1138
            SRV L  ++     DYINANY+ GY  +  +IATQGPLP T  DFWRMVWE+    I+M+
Sbjct: 1431 SRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMM 1490

Query: 1139 TKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQF 1198
            T+  E+ R KC++YWP++  + YG I V +   I L  + +R F++    +SE   +RQF
Sbjct: 1491 TRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQF 1550

Query: 1199 HFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPES-PILVHCSAGVGRTGTFIAIDRLIY 1257
             FT+WPDHGVP+     + F   +R     +PP++ PI+VHCSAGVGRTG FI ID ++ 
Sbjct: 1551 QFTAWPDHGVPEYPTPFLAF---LRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLE 1607

Query: 1258 QIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIV 1299
            +I+ E TVDVYG V  +R  R  MVQTEDQY F+++ +L+ V
Sbjct: 1608 RIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAV 1649



 Score =  210 bits (534), Expect = 8e-54
 Identities = 104/244 (42%), Positives = 152/244 (62%), Gaps = 1/244 (0%)

Query: 1059 AAELAENRGKNRYNNVLPYDISRVKLS-VQTHSTDDYINANYMPGYHSKKDFIATQGPLP 1117
            +A L  N+ KNR  N++PY+ +RV L  ++     DYINA+++ GY  +K +IATQGPL 
Sbjct: 1699 SANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLA 1758

Query: 1118 NTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEW 1177
             T +DFWRM+WE N   ++MLTK  E GR KC +YWP++++  Y    V   +E  +P++
Sbjct: 1759 ETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQY 1818

Query: 1178 TIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILV 1237
             +R+F V + +  +S  +RQF FT WP+ GVP + +  I+F   V    +Q   + PI V
Sbjct: 1819 ILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISV 1878

Query: 1238 HCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLD 1297
            HCSAGVGRTG FI +  ++ ++  E  VD++  V  LR  RP MVQTED+Y F  Q  L+
Sbjct: 1879 HCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALE 1938

Query: 1298 IVRS 1301
             + S
Sbjct: 1939 YLGS 1942



 Score = 45.4 bits (106), Expect = 4e-04
 Identities = 64/259 (24%), Positives = 103/259 (39%), Gaps = 24/259 (9%)

Query: 328 TEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTN----AIQVFDVTAVNISATSLT 383
           T   + GL P + Y   V +  + G     +++  RT     A    +V A  +SAT++ 
Sbjct: 385 TRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMI 444

Query: 384 LIWKVSDNESSSNYTYKI-------HVAGETDSSNLNVSEPRAVIPGLRSSTFYNITVCP 436
           + W+     +     Y++       H  G     N++ S    V   L   T Y + V  
Sbjct: 445 VQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDET-YTVRVLA 503

Query: 437 VLGDIEGTPGF-LQVHTP---PVPVSDFRVTVVSTTEIGLAWSSHDAESFQMH--ITQEG 490
                +G     +QV T    P    + R    S T I L+WS    ES   +  + +EG
Sbjct: 504 FTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREG 563

Query: 491 AGNSRVEITTNQ--SIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTV---PSA-VF 544
                V  T +   S ++  L P T+Y F +  + P G    +  V  RT+   PSA   
Sbjct: 564 DHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQ 623

Query: 545 DIHVVYVTTTEMWLDWKSP 563
           D+  V V +T + + W+ P
Sbjct: 624 DVKCVSVRSTAILVSWRPP 642



 Score = 44.3 bits (103), Expect = 8e-04
 Identities = 46/197 (23%), Positives = 77/197 (39%), Gaps = 39/197 (19%)

Query: 305  TAPVHDESLVGPVD----PSSGQQSRDTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAI 360
            T  V +   +GP      P++ +   +  + L GL+P T Y+  V +    G       +
Sbjct: 966  TVAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPV 1025

Query: 361  EFRT---NAIQVFDVTAVNISATSLTLIWKVSDNESSSNYTYKIHVAGETDSSNLNVSEP 417
             +RT   + +   +     I  TS+ L W+  DN +S    YKI   G T   +++    
Sbjct: 1026 RYRTFLRDQVSPKNFKVKMIMKTSVLLSWEFPDNYNSPT-PYKIQYNGLT--LDVDGRTT 1082

Query: 418  RAVIPGLRSSTFYN----------------ITVCPVLGDIEGTP---------GFLQVHT 452
            + +I  L+  TFYN                +T       + G P         GF+ V+ 
Sbjct: 1083 KKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYL 1142

Query: 453  P----PVPVSDFRVTVV 465
            P    PVPV  + + +V
Sbjct: 1143 PDGQSPVPVQSYFIVMV 1159


>gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1
            precursor [Homo sapiens]
          Length = 2315

 Score =  233 bits (593), Expect = 1e-60
 Identities = 170/566 (30%), Positives = 277/566 (48%), Gaps = 74/566 (13%)

Query: 784  NFSTSYNISITTVSCGKMAAPTRNTCTTGITDPPPPDGSPNITSVSHNSVKVKF-----S 838
            N   SY++S  +    ++ + + ++  TG+   P    S N  S  HN  K +      S
Sbjct: 1470 NNPISYSLSENSEEDNRVTSVSSDS-QTGMDRSPGKSPSANGLSQKHNDGKEENDIQTGS 1528

Query: 839  GFEASHGPIKAYAVILTTGEAGHPSADVLKYTYEDFKKGASDTYVTYLIRTEEKGRSQSL 898
                     KA+AV+ +  E+G         T +   +  + T  ++   T EK     L
Sbjct: 1529 ALLPLSPESKAWAVLTSDEESGSGQG-----TSDSLNENETSTDFSFA-DTNEKDADGIL 1582

Query: 899  SEVLKYEIDVGNESTTLGYYNGKLEPLGSYRACVAGFTNI----TFHPQNKGLIDGAESY 954
            +         G+   T G+       + S  + V   +      + H    GL +G ES 
Sbjct: 1583 A--------AGDSEITPGFPQSPTSSVTSENSEVFHVSEAEASNSSHESRIGLAEGLES- 1633

Query: 955  VSFSRYSDAVSLPQDPGVICGAVFGCIFGALVIVTVGGFIFWRKKRKDAK---NNEVSFS 1011
                         +   VI   +   +    ++V VG  I+WRK  + A     +  S  
Sbjct: 1634 -------------EKKAVIPLVIVSALTFICLVVLVGILIYWRKCFQTAHFYLEDSTSPR 1680

Query: 1012 QIKPKKSKLIRVENFEA-----YFKKQQAD--SNCGFAEEYEDLK---------LVGISQ 1055
             I    + +  + +        +F K  AD  ++ GF EE+E LK          V +  
Sbjct: 1681 VISTPPTPIFPISDDVGAIPIKHFPKHVADLHASSGFTEEFETLKEFYQEVQSCTVDLGI 1740

Query: 1056 PKYAAELAENRGKNRYNNVLPYDISRVKLSVQTHSTD---DYINANYMPGYHSKKDFIAT 1112
               ++   +N+ KNRY N++ YD SRVKL+          DYINANY+ GY+  K +IA 
Sbjct: 1741 TADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGKLTDYINANYVDGYNRPKAYIAA 1800

Query: 1113 QGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEI 1172
            QGPL +T +DFWRM+WE NV  I+M+T  VE+GR KC++YWP+  +++YG+  V   S  
Sbjct: 1801 QGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQ 1860

Query: 1173 VLPEWTIRDFTVKNIQTSE--------SHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRD 1224
            VL  +T+R+FT++N +  +           + Q+H+T WPD GVP+ +  ++ F   VR 
Sbjct: 1861 VLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTF---VRK 1917

Query: 1225 --YMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMV 1282
              Y K+     P++VHCSAGVGRTGT+I +D ++ QI++E TV+++G +  +R  R  +V
Sbjct: 1918 AAYAKRH-AVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLV 1976

Query: 1283 QTEDQYVFLNQCVLDIVRSQKDSKVD 1308
            QTE+QYVF++  +++ + S++   +D
Sbjct: 1977 QTEEQYVFIHDTLVEAILSKETEVLD 2002



 Score =  135 bits (341), Expect = 2e-31
 Identities = 84/272 (30%), Positives = 146/272 (53%), Gaps = 18/272 (6%)

Query: 1043 EEYEDLKLVGISQPKYAAELAE-NRGKNRYNNVLPYDISRVKLSVQTHSTDDYINANYMP 1101
            ++++ L    I Q  Y+A L + NR KNR ++++P + SRV +S  +    DYINA+Y+ 
Sbjct: 2025 KQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSGEGTDYINASYIM 2084

Query: 1102 GYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEE---YWPSK-- 1156
            GY+   +FI TQ PL +T+KDFWRM+W+ N   ++M    +  G+   E+   YWP+K  
Sbjct: 2085 GYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVM----IPDGQNMAEDEFVYWPNKDE 2140

Query: 1157 --QAQDYGDITVAMTSEIVLPE--WTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTT 1212
                + +    +A   + +  E    I+DF ++  Q      +R F    WP+   PD +
Sbjct: 2141 PINCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPN---PD-S 2196

Query: 1213 DLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVY 1272
             +   F  +     + +  + P++VH   G    GTF A+  L++Q+E EN+VDVY +  
Sbjct: 2197 PISKTFELISVIKEEAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAK 2256

Query: 1273 DLRMHRPLMVQTEDQYVFLNQCVLDIVRSQKD 1304
             + + RP +    +QY FL + +L +V ++++
Sbjct: 2257 MINLMRPGVFADIEQYQFLYKVILSLVSTRQE 2288


>gi|194097398 protein tyrosine phosphatase, receptor type, G precursor
            [Homo sapiens]
          Length = 1445

 Score =  231 bits (590), Expect = 3e-60
 Identities = 116/301 (38%), Positives = 187/301 (62%), Gaps = 18/301 (5%)

Query: 1015 PKKSKLIRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQPKYA--AELAENRGKNRYN 1072
            P   + I V+ F  +  +  +++  GF+E++E+++         A  +   EN+ KNRY 
Sbjct: 822  PDDMEAIPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTADMNITAEHSNHPENKHKNRYI 881

Query: 1073 NVLPYDISRVKLSV---QTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWE 1129
            N+L YD SRVKL     +     DYINANY+ GY+  K +IATQGPL +T +DFWRM+WE
Sbjct: 882  NILAYDHSRVKLRPLPGKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWE 941

Query: 1130 KNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQT 1189
            +N   I+M+T  VE+GR KC++YWP++ +++YG+I V + S  +   +T+R F+++N + 
Sbjct: 942  QNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKV 1001

Query: 1190 SESHP-----------LRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILVH 1238
             +              + Q+H+T WPD GVP+    ++ F  + R    + P   P+LVH
Sbjct: 1002 KKGQKGNPKGRQNERVVIQYHYTQWPDMGVPEYALPVLTF--VRRSSAARMPETGPVLVH 1059

Query: 1239 CSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDI 1298
            CSAGVGRTGT+I ID ++ QI++++TV+V G +  +R  R  +VQTE+QY+F++  +L+ 
Sbjct: 1060 CSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEA 1119

Query: 1299 V 1299
            +
Sbjct: 1120 I 1120



 Score =  125 bits (314), Expect = 3e-28
 Identities = 93/296 (31%), Positives = 145/296 (48%), Gaps = 26/296 (8%)

Query: 1046 EDLKLVGISQPKY----AAELAENRGKNRYNNVLPYDISRVKLS-VQTHSTDDYINANYM 1100
            +  KLV     KY    +A+   N+ KNR ++V+P + +RV L+ +      DYINA+Y+
Sbjct: 1152 KQFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYI 1211

Query: 1101 PGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCE-EYWPSK-QA 1158
             GY+   +FI TQ PLP+T KDFWRM+W+ N   I+ML     Q   + E  YWPS+ ++
Sbjct: 1212 MGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPD--NQSLAEDEFVYWPSREES 1269

Query: 1159 QDYGDITVAMTSEIVL-----PEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVP-DTT 1212
             +    TV + S+  L      +  I DF ++  Q      +R F    WP+   P  +T
Sbjct: 1270 MNCEAFTVTLISKDRLCLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPISST 1329

Query: 1213 DLLINF---RYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYG 1269
              LIN      L RD         P +VH   G    G   A+  L  Q+ENEN VDV+ 
Sbjct: 1330 FELINVIKEEALTRD--------GPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQ 1381

Query: 1270 IVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQKDSKVDLIYQNTTAMTIYENLAP 1325
            +   + + RP +    +QY F+ + +L +V ++++    +      A+ I +   P
Sbjct: 1382 VAKMINLMRPGVFTDIEQYQFIYKAMLSLVSTKENGNGPMTVDKNGAVLIADESDP 1437


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.131    0.389 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 54,742,405
Number of Sequences: 37866
Number of extensions: 2645034
Number of successful extensions: 7773
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 126
Number of HSP's successfully gapped in prelim test: 128
Number of HSP's that attempted gapping in prelim test: 5780
Number of HSP's gapped (non-prelim): 1311
length of query: 1337
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1223
effective length of database: 13,930,794
effective search space: 17037361062
effective search space used: 17037361062
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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