BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|148612875 RUN and TBC1 domain containing 2 isoform 4 [Homo sapiens] (1032 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|148612875 RUN and TBC1 domain containing 2 isoform 4 [Homo sa... 2086 0.0 gi|148612840 RUN and TBC1 domain containing 2 isoform 3 [Homo sa... 2048 0.0 gi|90577164 RUN and TBC1 domain containing 2 isoform 2 [Homo sap... 2039 0.0 gi|90577167 RUN and TBC1 domain containing 2 isoform 1 [Homo sap... 2000 0.0 gi|148612829 RUN and TBC1 domain containing 1 isoform 2 [Homo sa... 1138 0.0 gi|148612795 RUN and TBC1 domain containing 1 isoform 1 [Homo sa... 1123 0.0 gi|226342869 TBC1 domain family, member 15 isoform 2 [Homo sapiens] 125 2e-28 gi|226342867 TBC1 domain family, member 15 isoform 3 [Homo sapiens] 125 2e-28 gi|226342865 TBC1 domain family, member 15 isoform 1 [Homo sapiens] 125 2e-28 gi|33563376 TBC1 domain family, member 16 [Homo sapiens] 120 7e-27 gi|13375952 TBC1 domain family, member 17 [Homo sapiens] 118 3e-26 gi|54607014 TBC1 domain family, member 25 [Homo sapiens] 107 4e-23 gi|34147456 TBC domain-containing protein kinase-like [Homo sapi... 63 1e-09 gi|222352143 TBC1 domain family, member 2 [Homo sapiens] 58 4e-08 gi|109240556 RUN and FYVE domain-containing 2 isoform a [Homo sa... 55 3e-07 gi|190014603 TBC1 domain family, member 13 [Homo sapiens] 54 8e-07 gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens] 54 8e-07 gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens] 54 8e-07 gi|148806902 TBC1 domain family, member 12 [Homo sapiens] 54 1e-06 gi|94721330 RUN and FYVE domain-containing 1 isoform b [Homo sap... 53 1e-06 gi|94721332 RUN and FYVE domain-containing 1 isoform b [Homo sap... 53 1e-06 gi|94721336 RUN and FYVE domain-containing 1 isoform a [Homo sap... 53 1e-06 gi|22507409 TBC1 domain family, member 22A [Homo sapiens] 49 3e-05 gi|164565381 TBC1 domain family, member 14 isoform b [Homo sapiens] 49 3e-05 gi|164565368 TBC1 domain family, member 14 isoform a [Homo sapiens] 49 3e-05 gi|164565366 TBC1 domain family, member 14 isoform a [Homo sapiens] 49 3e-05 gi|114688046 TBC1 domain family, member 4 [Homo sapiens] 44 6e-04 gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo... 43 0.002 gi|197304777 TBC1 domain family, member 5 isoform a [Homo sapiens] 42 0.004 gi|197304775 TBC1 domain family, member 5 isoform b [Homo sapiens] 42 0.004 >gi|148612875 RUN and TBC1 domain containing 2 isoform 4 [Homo sapiens] Length = 1032 Score = 2087 bits (5406), Expect = 0.0 Identities = 1032/1032 (100%), Positives = 1032/1032 (100%) Query: 1 MASAPAEAETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRR 60 MASAPAEAETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRR Sbjct: 1 MASAPAEAETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRR 60 Query: 61 AAGFLRSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQENVRKLPKLPN 120 AAGFLRSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQENVRKLPKLPN Sbjct: 61 AAGFLRSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQENVRKLPKLPN 120 Query: 121 LSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCAL 180 LSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCAL Sbjct: 121 LSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCAL 180 Query: 181 EYTKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSMDDRPSLS 240 EYTKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSMDDRPSLS Sbjct: 181 EYTKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSMDDRPSLS 240 Query: 241 ARDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGS 300 ARDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGS Sbjct: 241 ARDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGS 300 Query: 301 VGDLDYEKSVYWDYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLL 360 VGDLDYEKSVYWDYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLL Sbjct: 301 VGDLDYEKSVYWDYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLL 360 Query: 361 QFLSCLENGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFR 420 QFLSCLENGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFR Sbjct: 361 QFLSCLENGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFR 420 Query: 421 IIYPGMQSEFVPQDLMDVSVSNLPSLWQPSPRKSSCSSCSQSGSADGSSTNGCNHERAPL 480 IIYPGMQSEFVPQDLMDVSVSNLPSLWQPSPRKSSCSSCSQSGSADGSSTNGCNHERAPL Sbjct: 421 IIYPGMQSEFVPQDLMDVSVSNLPSLWQPSPRKSSCSSCSQSGSADGSSTNGCNHERAPL 480 Query: 481 KLLCDNMKYQILSRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWE 540 KLLCDNMKYQILSRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWE Sbjct: 481 KLLCDNMKYQILSRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWE 540 Query: 541 QYLHDSTSYEEQELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKESSQSCSSGRQ 600 QYLHDSTSYEEQELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKESSQSCSSGRQ Sbjct: 541 QYLHDSTSYEEQELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKESSQSCSSGRQ 600 Query: 601 NIRLHSDSSSSTQVFESVDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSHNFS 660 NIRLHSDSSSSTQVFESVDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSHNFS Sbjct: 601 NIRLHSDSSSSTQVFESVDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSHNFS 660 Query: 661 SGLSEHSEPSLSTEDSVLDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELAVQDS 720 SGLSEHSEPSLSTEDSVLDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELAVQDS Sbjct: 661 SGLSEHSEPSLSTEDSVLDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELAVQDS 720 Query: 721 LESDLLANESMDEFMSITGSLDMALPEKDDVVMEGWRSSETEKHGQADSEDNLSEEPEME 780 LESDLLANESMDEFMSITGSLDMALPEKDDVVMEGWRSSETEKHGQADSEDNLSEEPEME Sbjct: 721 LESDLLANESMDEFMSITGSLDMALPEKDDVVMEGWRSSETEKHGQADSEDNLSEEPEME 780 Query: 781 SLFPALASLAVTTSANEVSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYFTPA 840 SLFPALASLAVTTSANEVSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYFTPA Sbjct: 781 SLFPALASLAVTTSANEVSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYFTPA 840 Query: 841 NLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNFPHG 900 NLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNFPHG Sbjct: 841 NLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNFPHG 900 Query: 901 GAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWET 960 GAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWET Sbjct: 901 GAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWET 960 Query: 961 IWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARD 1020 IWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARD Sbjct: 961 IWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARD 1020 Query: 1021 LVYKVQTLIENK 1032 LVYKVQTLIENK Sbjct: 1021 LVYKVQTLIENK 1032 >gi|148612840 RUN and TBC1 domain containing 2 isoform 3 [Homo sapiens] Length = 1093 Score = 2048 bits (5306), Expect = 0.0 Identities = 1028/1093 (94%), Positives = 1029/1093 (94%), Gaps = 61/1093 (5%) Query: 1 MASAPAEAETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRR 60 MASAPAEAETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRR Sbjct: 1 MASAPAEAETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRR 60 Query: 61 AAGFLRSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQENVRKLPKLPN 120 AAGFLRSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQENVRKLPKLPN Sbjct: 61 AAGFLRSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQENVRKLPKLPN 120 Query: 121 LSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCAL 180 LSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCAL Sbjct: 121 LSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCAL 180 Query: 181 EYTKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSMDDRPSLS 240 EYTKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSMDDRPSLS Sbjct: 181 EYTKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSMDDRPSLS 240 Query: 241 ARDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGS 300 ARDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGS Sbjct: 241 ARDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGS 300 Query: 301 VGDLDYEKSVYWDYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLL 360 VGDLDYEKSVYWDYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLL Sbjct: 301 VGDLDYEKSVYWDYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLL 360 Query: 361 QFLSCLENGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFR 420 QFLSCLENGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFR Sbjct: 361 QFLSCLENGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFR 420 Query: 421 IIYPGMQSEFVPQDLMDVSVSNLPSLWQPSPRKSSCSSCSQSGSADGSSTNGCNHERAPL 480 IIYPGMQSEFVPQDLMDVSVSNLPSLWQPSPRKSSCSSCSQSGSADGSSTNGCNHERAPL Sbjct: 421 IIYPGMQSEFVPQDLMDVSVSNLPSLWQPSPRKSSCSSCSQSGSADGSSTNGCNHERAPL 480 Query: 481 KLLCDNMKYQILSRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWE 540 KLLCDNMKYQILSRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWE Sbjct: 481 KLLCDNMKYQILSRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWE 540 Query: 541 QYLHDSTSYEEQELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKESSQ------- 593 QYLHDSTSYEEQELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKE + Sbjct: 541 QYLHDSTSYEEQELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKEVDEQIHACYA 600 Query: 594 --------------------------SCSSG----------------------------R 599 CSSG R Sbjct: 601 QTMAEWLGCEAIVRQRERESHAAALAKCSSGASLDSHLHRMLHRDSTISNESSQSCSSGR 660 Query: 600 QNIRLHSDSSSSTQVFESVDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSHNF 659 QNIRLHSDSSSSTQVFESVDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSHNF Sbjct: 661 QNIRLHSDSSSSTQVFESVDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSHNF 720 Query: 660 SSGLSEHSEPSLSTEDSVLDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELAVQD 719 SSGLSEHSEPSLSTEDSVLDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELAVQD Sbjct: 721 SSGLSEHSEPSLSTEDSVLDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELAVQD 780 Query: 720 SLESDLLANESMDEFMSITGSLDMALPEKDDVVMEGWRSSETEKHGQADSEDNLSEEPEM 779 SLESDLLANESMDEFMSITGSLDMALPEKDDVVMEGWRSSETEKHGQADSEDNLSEEPEM Sbjct: 781 SLESDLLANESMDEFMSITGSLDMALPEKDDVVMEGWRSSETEKHGQADSEDNLSEEPEM 840 Query: 780 ESLFPALASLAVTTSANEVSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYFTP 839 ESLFPALASLAVTTSANEVSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYFTP Sbjct: 841 ESLFPALASLAVTTSANEVSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYFTP 900 Query: 840 ANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNFPH 899 ANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNFPH Sbjct: 901 ANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNFPH 960 Query: 900 GGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWE 959 GGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWE Sbjct: 961 GGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWE 1020 Query: 960 TIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLAR 1019 TIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLAR Sbjct: 1021 TIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLAR 1080 Query: 1020 DLVYKVQTLIENK 1032 DLVYKVQTLIENK Sbjct: 1081 DLVYKVQTLIENK 1093 >gi|90577164 RUN and TBC1 domain containing 2 isoform 2 [Homo sapiens] Length = 1087 Score = 2039 bits (5282), Expect = 0.0 Identities = 1025/1087 (94%), Positives = 1027/1087 (94%), Gaps = 55/1087 (5%) Query: 1 MASAPAEAETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRR 60 MASAPAEAETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRR Sbjct: 1 MASAPAEAETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRR 60 Query: 61 AAGFLRSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQENVRKLPKLPN 120 AAGFLRSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQENVRKLPKLPN Sbjct: 61 AAGFLRSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQENVRKLPKLPN 120 Query: 121 LSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCAL 180 LSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCAL Sbjct: 121 LSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCAL 180 Query: 181 EYTKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSMDDRPSLS 240 EYTKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSMDDRPSLS Sbjct: 181 EYTKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSMDDRPSLS 240 Query: 241 ARDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGS 300 ARDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGS Sbjct: 241 ARDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGS 300 Query: 301 VGDLDYEKSVYWDYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLL 360 VGDLDYEKSVYWDYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLL Sbjct: 301 VGDLDYEKSVYWDYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLL 360 Query: 361 QFLSCLENGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFR 420 QFLSCLENGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFR Sbjct: 361 QFLSCLENGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFR 420 Query: 421 IIYPGMQSEFVPQDLM----DVSV----------------------------SNLP---- 444 IIYPGMQSEFV D + VSV + LP Sbjct: 421 IIYPGMQSEFVAPDFLGSTSSVSVGPAWMMVPAGRSMLVVARGSQWEPARWDTTLPTPSP 480 Query: 445 -------------------SLWQPSPRKSSCSSCSQSGSADGSSTNGCNHERAPLKLLCD 485 SLWQPSPRKSSCSSCSQSGSADGSSTNGCNHERAPLKLLCD Sbjct: 481 KEQPPMPQDLMDVSVSNLPSLWQPSPRKSSCSSCSQSGSADGSSTNGCNHERAPLKLLCD 540 Query: 486 NMKYQILSRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWEQYLHD 545 NMKYQILSRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWEQYLHD Sbjct: 541 NMKYQILSRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWEQYLHD 600 Query: 546 STSYEEQELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKESSQSCSSGRQNIRLH 605 STSYEEQELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKESSQSCSSGRQNIRLH Sbjct: 601 STSYEEQELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKESSQSCSSGRQNIRLH 660 Query: 606 SDSSSSTQVFESVDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSHNFSSGLSE 665 SDSSSSTQVFESVDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSHNFSSGLSE Sbjct: 661 SDSSSSTQVFESVDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSHNFSSGLSE 720 Query: 666 HSEPSLSTEDSVLDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELAVQDSLESDL 725 HSEPSLSTEDSVLDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELAVQDSLESDL Sbjct: 721 HSEPSLSTEDSVLDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELAVQDSLESDL 780 Query: 726 LANESMDEFMSITGSLDMALPEKDDVVMEGWRSSETEKHGQADSEDNLSEEPEMESLFPA 785 LANESMDEFMSITGSLDMALPEKDDVVMEGWRSSETEKHGQADSEDNLSEEPEMESLFPA Sbjct: 781 LANESMDEFMSITGSLDMALPEKDDVVMEGWRSSETEKHGQADSEDNLSEEPEMESLFPA 840 Query: 786 LASLAVTTSANEVSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYFTPANLEKL 845 LASLAVTTSANEVSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYFTPANLEKL Sbjct: 841 LASLAVTTSANEVSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYFTPANLEKL 900 Query: 846 RNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNFPHGGAMDT 905 RNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNFPHGGAMDT Sbjct: 901 RNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNFPHGGAMDT 960 Query: 906 HFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAAK 965 HFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAAK Sbjct: 961 HFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAAK 1020 Query: 966 HVSSAHYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYKV 1025 HVSSAHYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYKV Sbjct: 1021 HVSSAHYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYKV 1080 Query: 1026 QTLIENK 1032 QTLIENK Sbjct: 1081 QTLIENK 1087 >gi|90577167 RUN and TBC1 domain containing 2 isoform 1 [Homo sapiens] Length = 1148 Score = 2000 bits (5182), Expect = 0.0 Identities = 1021/1148 (88%), Positives = 1024/1148 (89%), Gaps = 116/1148 (10%) Query: 1 MASAPAEAETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRR 60 MASAPAEAETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRR Sbjct: 1 MASAPAEAETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRR 60 Query: 61 AAGFLRSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQENVRKLPKLPN 120 AAGFLRSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQENVRKLPKLPN Sbjct: 61 AAGFLRSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQENVRKLPKLPN 120 Query: 121 LSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCAL 180 LSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCAL Sbjct: 121 LSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCAL 180 Query: 181 EYTKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSMDDRPSLS 240 EYTKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSMDDRPSLS Sbjct: 181 EYTKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSMDDRPSLS 240 Query: 241 ARDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGS 300 ARDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGS Sbjct: 241 ARDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGS 300 Query: 301 VGDLDYEKSVYWDYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLL 360 VGDLDYEKSVYWDYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLL Sbjct: 301 VGDLDYEKSVYWDYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLL 360 Query: 361 QFLSCLENGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFR 420 QFLSCLENGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFR Sbjct: 361 QFLSCLENGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFR 420 Query: 421 IIYPGMQSEFVPQDLM----DVSV----------------------------SNLP---- 444 IIYPGMQSEFV D + VSV + LP Sbjct: 421 IIYPGMQSEFVAPDFLGSTSSVSVGPAWMMVPAGRSMLVVARGSQWEPARWDTTLPTPSP 480 Query: 445 -------------------SLWQPSPRKSSCSSCSQSGSADGSSTNGCNHERAPLKLLCD 485 SLWQPSPRKSSCSSCSQSGSADGSSTNGCNHERAPLKLLCD Sbjct: 481 KEQPPMPQDLMDVSVSNLPSLWQPSPRKSSCSSCSQSGSADGSSTNGCNHERAPLKLLCD 540 Query: 486 NMKYQILSRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWEQYLHD 545 NMKYQILSRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWEQYLHD Sbjct: 541 NMKYQILSRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWEQYLHD 600 Query: 546 STSYEEQELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKESSQ------------ 593 STSYEEQELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKE + Sbjct: 601 STSYEEQELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKEVDEQIHACYAQTMAE 660 Query: 594 ---------------------SCSSG----------------------------RQNIRL 604 CSSG RQNIRL Sbjct: 661 WLGCEAIVRQRERESHAAALAKCSSGASLDSHLHRMLHRDSTISNESSQSCSSGRQNIRL 720 Query: 605 HSDSSSSTQVFESVDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSHNFSSGLS 664 HSDSSSSTQVFESVDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSHNFSSGLS Sbjct: 721 HSDSSSSTQVFESVDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSHNFSSGLS 780 Query: 665 EHSEPSLSTEDSVLDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELAVQDSLESD 724 EHSEPSLSTEDSVLDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELAVQDSLESD Sbjct: 781 EHSEPSLSTEDSVLDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELAVQDSLESD 840 Query: 725 LLANESMDEFMSITGSLDMALPEKDDVVMEGWRSSETEKHGQADSEDNLSEEPEMESLFP 784 LLANESMDEFMSITGSLDMALPEKDDVVMEGWRSSETEKHGQADSEDNLSEEPEMESLFP Sbjct: 841 LLANESMDEFMSITGSLDMALPEKDDVVMEGWRSSETEKHGQADSEDNLSEEPEMESLFP 900 Query: 785 ALASLAVTTSANEVSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYFTPANLEK 844 ALASLAVTTSANEVSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYFTPANLEK Sbjct: 901 ALASLAVTTSANEVSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYFTPANLEK 960 Query: 845 LRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNFPHGGAMD 904 LRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNFPHGGAMD Sbjct: 961 LRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNFPHGGAMD 1020 Query: 905 THFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAA 964 THFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAA Sbjct: 1021 THFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAA 1080 Query: 965 KHVSSAHYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYK 1024 KHVSSAHYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYK Sbjct: 1081 KHVSSAHYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYK 1140 Query: 1025 VQTLIENK 1032 VQTLIENK Sbjct: 1141 VQTLIENK 1148 >gi|148612829 RUN and TBC1 domain containing 1 isoform 2 [Homo sapiens] Length = 1006 Score = 1138 bits (2943), Expect = 0.0 Identities = 601/1051 (57%), Positives = 736/1051 (70%), Gaps = 72/1051 (6%) Query: 6 AEAETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRRAAGFL 65 AE +++LL VKKEVKQIMEEAVTRKFVHEDSSHII+ C AVEAC+LH LRRRAAGFL Sbjct: 4 AEDAVKEKLLWNVKKEVKQIMEEAVTRKFVHEDSSHIIALCGAVEACLLHQLRRRAAGFL 63 Query: 66 RSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQ---IQGLQENVRKLPKLPNLS 122 RS+K+AALF KVGK P A ++ KVQ+L+Q E + + L+ K P LS Sbjct: 64 RSDKMAALFTKVGKTCPVAGEICHKVQELQQQAEGRKPSGVSQEALRRQGSASGKAPALS 123 Query: 123 PLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCALEY 182 P A+KH+W+RTAL EKVLDK+V YL EN SKYYEKEALL DPV GPILASLLVGPCALEY Sbjct: 124 PQALKHVWVRTALIEKVLDKVVQYLAENCSKYYEKEALLADPVFGPILASLLVGPCALEY 183 Query: 183 TKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSM-DDRPSLSA 241 TK+KTADH+WTDPSADELVQRHRI RQDSP KRPAL I+KRHSSGS +DR + A Sbjct: 184 TKLKTADHYWTDPSADELVQRHRIRGPPTRQDSPAKRPALGIRKRHSSGSASEDRLAACA 243 Query: 242 RDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGSV 301 R+ VESLHQNSR LLYGKN+VLVQP++DMEAVPGYLSLHQ+A+ +TLKWTPNQLMNG++ Sbjct: 244 RECVESLHQNSRTRLLYGKNHVLVQPKEDMEAVPGYLSLHQSAESLTLKWTPNQLMNGTL 303 Query: 302 GDLDYEKSVYWDYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLLQ 361 GD + EKSVYWDYA+ + ++V +HCHQQ SGGT+VLVSQDGIQRPP FP+GGHLL Sbjct: 304 GDSELEKSVYWDYALVVPFSQVVCIHCHQQ-KSGGTLVLVSQDGIQRPPLHFPQGGHLLS 362 Query: 362 FLSCLENGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFRI 421 FLSCLENGLLP GQL+PPLW+Q+GKGKVFPKLRKRS S + + ATDYVFRI Sbjct: 363 FLSCLENGLLPRGQLEPPLWTQQGKGKVFPKLRKRSSIRSVDM--EEMGTGRATDYVFRI 420 Query: 422 IYPGMQSEFVPQDLMDVSVSNLPSL--WQPSP---RKSSCSSCSQSGSADGSSTN-GCNH 475 IYPG + E D++++ PSL W P + SSC SCS S S + ++ C Sbjct: 421 IYPGHRHEHNAGDMIEMQGFG-PSLPAWHLEPLCSQGSSCLSCSSSSSPHATPSHCSCIP 479 Query: 476 ERAPLKLLCDNMKYQILSRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLT 535 +R PL+LLC++MK QI+SRAFYGWLA+CRHLSTVRTHLSALV+H ++ PD P A GLT Sbjct: 480 DRLPLRLLCESMKRQIVSRAFYGWLAHCRHLSTVRTHLSALVHHSVIPPDRPPGASAGLT 539 Query: 536 ARIWEQYLHDSTSYEEQELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKESSQSC 595 +W +Y D +Y+E ELLR +YYGGI+ EIRK VWPFLLGHY+FGM++ E ++ Sbjct: 540 KDVWSKYQKDKKNYKELELLRQVYYGGIEHEIRKDVWPFLLGHYKFGMSKKEMEQVDAVV 599 Query: 596 SSGRQNIRLHSDSSSSTQVFESVDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPS 655 ++ Q + + E + E R E++ HP+ Sbjct: 600 AARYQQV---------------LAEWKACEVVVRQRERE-----------------AHPA 627 Query: 656 SHN-FSSGLSE--------HSEPSLSTEDSVLDAQRNTPTVLRPRDGSVDDRQSSEATTS 706 + FSSG S H + ++S + + P P D Q + T Sbjct: 628 TRTKFSSGSSIDSHVQRLIHRDSTISNDVFISVDDLEPPEPQDPEDSRPKPEQEAGPGTP 687 Query: 707 QDEAPREELAVQ-DSLESDLLANESMDEFMSITGSLD----MALPEKDDVVMEGWRSSET 761 ++ +V+ DS +S L ++ + I SLD + E+D EG Sbjct: 688 GTAVVEQQHSVEFDSPDSGLPSSRNYSVASGIQSSLDEGQSVGFEEEDGGGEEGSSGPGP 747 Query: 762 EKHGQADSEDNLSEEPEMESLFPALASLAVTTSANEVSPVSSSGVTYSPELLDLYTVNLH 821 H + +D E+P+ L AV +A Y+ ELLD +NLH Sbjct: 748 AAHTLREPQDPSQEKPQAGELEAGEELAAVCAAA------------YTIELLDTVALNLH 795 Query: 822 RIEKDVQRCDRNYWYFTPANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEAL 881 RI+KDVQRCDRNYWYFTP NLE+LR++MCSY+W+H+++GYVQGMCDLLAPLLV LD++ L Sbjct: 796 RIDKDVQRCDRNYWYFTPPNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQL 855 Query: 882 AFSCFTELMKRMNQNFPHGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWF 941 A+SCF+ LMKRM+QNFP+GGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWF Sbjct: 856 AYSCFSHLMKRMSQNFPNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWF 915 Query: 942 LLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDIIKF 1001 LLDFKREL+Y+DVF VWE IWAA+H+SS H+VLFIALALVE YR+II +NNMDFTDIIKF Sbjct: 916 LLDFKRELLYEDVFAVWEVIWAARHISSEHFVLFIALALVEAYREIIRDNNMDFTDIIKF 975 Query: 1002 FNEMAERHNTKQVLKLARDLVYKVQTLIENK 1032 FNE AE H+ +++L++ARDLV+KVQ LIENK Sbjct: 976 FNERAEHHDAQEILRIARDLVHKVQMLIENK 1006 >gi|148612795 RUN and TBC1 domain containing 1 isoform 1 [Homo sapiens] Length = 1051 Score = 1123 bits (2905), Expect = 0.0 Identities = 601/1095 (54%), Positives = 736/1095 (67%), Gaps = 115/1095 (10%) Query: 6 AEAETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRRAAGFL 65 AE +++LL VKKEVKQIMEEAVTRKFVHEDSSHII+ C AVEAC+LH LRRRAAGFL Sbjct: 4 AEDAVKEKLLWNVKKEVKQIMEEAVTRKFVHEDSSHIIALCGAVEACLLHQLRRRAAGFL 63 Query: 66 RSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQ---IQGLQENVRKLPKLPNLS 122 RS+K+AALF KVGK P A ++ KVQ+L+Q E + + L+ K P LS Sbjct: 64 RSDKMAALFTKVGKTCPVAGEICHKVQELQQQAEGRKPSGVSQEALRRQGSASGKAPALS 123 Query: 123 PLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCALEY 182 P A+KH+W+RTAL EKVLDK+V YL EN SKYYEKEALL DPV GPILASLLVGPCALEY Sbjct: 124 PQALKHVWVRTALIEKVLDKVVQYLAENCSKYYEKEALLADPVFGPILASLLVGPCALEY 183 Query: 183 TKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSM-DDRPSLSA 241 TK+KTADH+WTDPSADELVQRHRI RQDSP KRPAL I+KRHSSGS +DR + A Sbjct: 184 TKLKTADHYWTDPSADELVQRHRIRGPPTRQDSPAKRPALGIRKRHSSGSASEDRLAACA 243 Query: 242 RDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGSV 301 R+ VESLHQNSR LLYGKN+VLVQP++DMEAVPGYLSLHQ+A+ +TLKWTPNQLMNG++ Sbjct: 244 RECVESLHQNSRTRLLYGKNHVLVQPKEDMEAVPGYLSLHQSAESLTLKWTPNQLMNGTL 303 Query: 302 GDLDYEKSVYWDYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLLQ 361 GD + EKSVYWDYA+ + ++V +HCHQQ SGGT+VLVSQDGIQRPP FP+GGHLL Sbjct: 304 GDSELEKSVYWDYALVVPFSQVVCIHCHQQ-KSGGTLVLVSQDGIQRPPLHFPQGGHLLS 362 Query: 362 FLSCLENGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFRI 421 FLSCLENGLLP GQL+PPLW+Q+GKGKVFPKLRKRS S + + ATDYVFRI Sbjct: 363 FLSCLENGLLPRGQLEPPLWTQQGKGKVFPKLRKRSSIRSVDM--EEMGTGRATDYVFRI 420 Query: 422 IYPGMQSEFVPQDLMDVSVSNLPS----------------------LWQPSPRK------ 453 IYPG + E + + ++ S S L P+P K Sbjct: 421 IYPGHRHEHITINYHHLAASRAASVDDDEEEEDKLHAMLSMICSRNLTAPNPMKDAGDMI 480 Query: 454 ---------------------SSCSSCSQSGSADGSSTN-GCNHERAPLKLLCDNMKYQI 491 SSC SCS S S + ++ C +R PL+LLC++MK QI Sbjct: 481 EMQGFGPSLPAWHLEPLCSQGSSCLSCSSSSSPHATPSHCSCIPDRLPLRLLCESMKRQI 540 Query: 492 LSRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWEQYLHDSTSYEE 551 +SRAFYGWLA+CRHLSTVRTHLSALV+H ++ PD P A GLT +W +Y D +Y+E Sbjct: 541 VSRAFYGWLAHCRHLSTVRTHLSALVHHSVIPPDRPPGASAGLTKDVWSKYQKDKKNYKE 600 Query: 552 QELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKESSQSCSSGRQNIRLHSDSSSS 611 ELLR +YYGGI+ EIRK VWPFLLGHY+FGM++ E ++ ++ Q + Sbjct: 601 LELLRQVYYGGIEHEIRKDVWPFLLGHYKFGMSKKEMEQVDAVVAARYQQV--------- 651 Query: 612 TQVFESVDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSHN-FSSGLSE----- 665 + E + E R E++ HP++ FSSG S Sbjct: 652 ------LAEWKACEVVVRQRERE-----------------AHPATRTKFSSGSSIDSHVQ 688 Query: 666 ---HSEPSLSTEDSVLDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELAVQ-DSL 721 H + ++S + + P P D Q + T ++ +V+ DS Sbjct: 689 RLIHRDSTISNDVFISVDDLEPPEPQDPEDSRPKPEQEAGPGTPGTAVVEQQHSVEFDSP 748 Query: 722 ESDLLANESMDEFMSITGSLD----MALPEKDDVVMEGWRSSETEKHGQADSEDNLSEEP 777 +S L ++ + I SLD + E+D EG H + +D E+P Sbjct: 749 DSGLPSSRNYSVASGIQSSLDEGQSVGFEEEDGGGEEGSSGPGPAAHTLREPQDPSQEKP 808 Query: 778 EMESLFPALASLAVTTSANEVSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYF 837 + L AV +A Y+ ELLD +NLHRI+KDVQRCDRNYWYF Sbjct: 809 QAGELEAGEELAAVCAAA------------YTIELLDTVALNLHRIDKDVQRCDRNYWYF 856 Query: 838 TPANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNF 897 TP NLE+LR++MCSY+W+H+++GYVQGMCDLLAPLLV LD++ LA+SCF+ LMKRM+QNF Sbjct: 857 TPPNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQLAYSCFSHLMKRMSQNF 916 Query: 898 PHGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLV 957 P+GGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKREL+Y+DVF V Sbjct: 917 PNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELLYEDVFAV 976 Query: 958 WETIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKL 1017 WE IWAA+H+SS H+VLFIALALVE YR+II +NNMDFTDIIKFFNE AE H+ +++L++ Sbjct: 977 WEVIWAARHISSEHFVLFIALALVEAYREIIRDNNMDFTDIIKFFNERAEHHDAQEILRI 1036 Query: 1018 ARDLVYKVQTLIENK 1032 ARDLV+KVQ LIENK Sbjct: 1037 ARDLVHKVQMLIENK 1051 >gi|226342869 TBC1 domain family, member 15 isoform 2 [Homo sapiens] Length = 682 Score = 125 bits (314), Expect = 2e-28 Identities = 70/197 (35%), Positives = 114/197 (57%), Gaps = 7/197 (3%) Query: 823 IEKDVQRCDR-NYWYFTPAN--LEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDE 879 IEKDV R DR N +Y N L L +I+ +Y ++GYVQGM DLL+PLL ++++E Sbjct: 402 IEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENE 461 Query: 880 ALAFSCFTELMKRMNQNFPHG-GAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCY 938 AF CF M +M+QNF M T + +L+++LDS + ++ D + YFC+ Sbjct: 462 VDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYL-ESQDSGYLYFCF 520 Query: 939 RWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDI 998 RW L+ FKRE + D+ +WE +W ++ H L + A++E + I+E + F +I Sbjct: 521 RWLLIRFKREFSFLDILRLWEVMWTELPCTNFH--LLLCCAILESEKQQIMEKHYGFNEI 578 Query: 999 IKFFNEMAERHNTKQVL 1015 +K NE++ + + + +L Sbjct: 579 LKHINELSMKIDVEDIL 595 Score = 36.2 bits (82), Expect = 0.16 Identities = 17/58 (29%), Positives = 31/58 (53%) Query: 556 RLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKESSQSCSSGRQNIRLHSDSSSSTQ 613 ++I+ GG+ +RK W FLLG++ + T+ ER + + + ++L S S Q Sbjct: 331 QMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTDEYFRMKLQWKSISQEQ 388 >gi|226342867 TBC1 domain family, member 15 isoform 3 [Homo sapiens] Length = 696 Score = 125 bits (314), Expect = 2e-28 Identities = 70/197 (35%), Positives = 114/197 (57%), Gaps = 7/197 (3%) Query: 823 IEKDVQRCDR-NYWYFTPAN--LEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDE 879 IEKDV R DR N +Y N L L +I+ +Y ++GYVQGM DLL+PLL ++++E Sbjct: 416 IEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENE 475 Query: 880 ALAFSCFTELMKRMNQNFPHG-GAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCY 938 AF CF M +M+QNF M T + +L+++LDS + ++ D + YFC+ Sbjct: 476 VDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYL-ESQDSGYLYFCF 534 Query: 939 RWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDI 998 RW L+ FKRE + D+ +WE +W ++ H L + A++E + I+E + F +I Sbjct: 535 RWLLIRFKREFSFLDILRLWEVMWTELPCTNFH--LLLCCAILESEKQQIMEKHYGFNEI 592 Query: 999 IKFFNEMAERHNTKQVL 1015 +K NE++ + + + +L Sbjct: 593 LKHINELSMKIDVEDIL 609 Score = 36.2 bits (82), Expect = 0.16 Identities = 17/58 (29%), Positives = 31/58 (53%) Query: 556 RLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKESSQSCSSGRQNIRLHSDSSSSTQ 613 ++I+ GG+ +RK W FLLG++ + T+ ER + + + ++L S S Q Sbjct: 345 QMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTDEYFRMKLQWKSISQEQ 402 >gi|226342865 TBC1 domain family, member 15 isoform 1 [Homo sapiens] Length = 713 Score = 125 bits (314), Expect = 2e-28 Identities = 70/197 (35%), Positives = 114/197 (57%), Gaps = 7/197 (3%) Query: 823 IEKDVQRCDR-NYWYFTPAN--LEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDE 879 IEKDV R DR N +Y N L L +I+ +Y ++GYVQGM DLL+PLL ++++E Sbjct: 433 IEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENE 492 Query: 880 ALAFSCFTELMKRMNQNFPHG-GAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCY 938 AF CF M +M+QNF M T + +L+++LDS + ++ D + YFC+ Sbjct: 493 VDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYL-ESQDSGYLYFCF 551 Query: 939 RWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDI 998 RW L+ FKRE + D+ +WE +W ++ H L + A++E + I+E + F +I Sbjct: 552 RWLLIRFKREFSFLDILRLWEVMWTELPCTNFH--LLLCCAILESEKQQIMEKHYGFNEI 609 Query: 999 IKFFNEMAERHNTKQVL 1015 +K NE++ + + + +L Sbjct: 610 LKHINELSMKIDVEDIL 626 Score = 36.2 bits (82), Expect = 0.16 Identities = 17/58 (29%), Positives = 31/58 (53%) Query: 556 RLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKESSQSCSSGRQNIRLHSDSSSSTQ 613 ++I+ GG+ +RK W FLLG++ + T+ ER + + + ++L S S Q Sbjct: 362 QMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTDEYFRMKLQWKSISQEQ 419 >gi|33563376 TBC1 domain family, member 16 [Homo sapiens] Length = 767 Score = 120 bits (301), Expect = 7e-27 Identities = 74/238 (31%), Positives = 124/238 (52%), Gaps = 8/238 (3%) Query: 797 EVSPVSSSGVTYSPELLDLYTVNLH-RIEKDVQRCDRNYWYFTPA---NLEKLRNIMCSY 852 E S + ++ +PE + N+ ++KDV R DRN +F N+E +R I+ +Y Sbjct: 461 EYSEIQQKRLSMTPEEHRAFWRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNY 520 Query: 853 IWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKR-MNQNFPHGGAMDTHFANMR 911 + +GY QGM DL+AP+L + DE+ F CF LM+ + + P M+ +R Sbjct: 521 AVYNPAVGYSQGMSDLVAPILAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLLYLR 580 Query: 912 SLIQILDSELFE-LMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAAKHVSSA 970 L+++ ++ L+ D FC+RW LL FKRE + +WE WA H + Sbjct: 581 ELLRLTHVRFYQHLVSLGEDGLQMLFCHRWLLLCFKREFPEAEALRIWEACWA--HYQTD 638 Query: 971 HYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYKVQTL 1028 ++ LFI +A+V +Y D ++E + ++ F +A N + VL+ AR L+Y+ + L Sbjct: 639 YFHLFICVAIVAIYGDDVIEQQLATDQMLLHFGNLAMHMNGELVLRKARSLLYQFRLL 696 Score = 43.1 bits (100), Expect = 0.001 Identities = 22/52 (42%), Positives = 30/52 (57%), Gaps = 1/52 (1%) Query: 539 WEQYLHDSTSYEEQELLR-LIYYGGIQPEIRKAVWPFLLGHYQFGMTETERK 589 W +L++ EE+ LR I++GGI IR VWPFLL +Y T ER+ Sbjct: 401 WLNHLNELGQVEEEYKLRKAIFFGGIDVSIRGEVWPFLLRYYSHESTSEERE 452 Score = 34.3 bits (77), Expect = 0.62 Identities = 18/48 (37%), Positives = 25/48 (52%), Gaps = 9/48 (18%) Query: 256 LLYGKNNVLVQPRDDMEAV----PGYLSLHQTADVM-----TLKWTPN 294 ++Y KNNV V P + ++ + PGYL L+ D M L W PN Sbjct: 37 IIYSKNNVCVHPPEGLQGLGEHHPGYLCLYMEKDEMLGATLILAWVPN 84 >gi|13375952 TBC1 domain family, member 17 [Homo sapiens] Length = 648 Score = 118 bits (295), Expect = 3e-26 Identities = 69/203 (33%), Positives = 110/203 (54%), Gaps = 7/203 (3%) Query: 823 IEKDVQRCDR-NYWYFTPAN--LEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDE 879 IE+DV R DR N +Y P N L L +I+ +Y H ++GYVQGM DLL+P+L ++ +E Sbjct: 375 IERDVSRTDRTNKFYEGPENPGLGLLNDILLTYCMYHFDLGYVQGMSDLLSPILYVIQNE 434 Query: 880 ALAFSCFTELMKRMNQNFPHG-GAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCY 938 AF CF M+ + NF M + L+++LD L + + + D FC+ Sbjct: 435 VDAFWCFCGFMELVQGNFEESQETMKRQLGRLLLLLRVLDPLLCDFL-DSQDSGSLCFCF 493 Query: 939 RWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDI 998 RW L+ FKRE + DV +WE +W + H L +A A++++ RD ++ + +I Sbjct: 494 RWLLIWFKREFPFPDVLRLWEVLWTGLPGPNLH--LLVACAILDMERDTLMLSGFGSNEI 551 Query: 999 IKFFNEMAERHNTKQVLKLARDL 1021 +K NE+ + + + VL A L Sbjct: 552 LKHINELTMKLSVEDVLTRAEAL 574 Score = 37.0 bits (84), Expect = 0.096 Identities = 19/69 (27%), Positives = 33/69 (47%), Gaps = 1/69 (1%) Query: 522 VSPDLPCDAGQGLTARIWEQYLHDSTSYEE-QELLRLIYYGGIQPEIRKAVWPFLLGHYQ 580 + P + G +T W +++ ++ EL I+ GG+ P +R+ W FLLG+ Sbjct: 269 LGPRPTVERGPPVTEEEWARHVGPEGRLQQVPELKNRIFSGGLSPSLRREAWKFLLGYLS 328 Query: 581 FGMTETERK 589 + T E K Sbjct: 329 WEGTAEEHK 337 >gi|54607014 TBC1 domain family, member 25 [Homo sapiens] Length = 688 Score = 107 bits (268), Expect = 4e-23 Identities = 54/145 (37%), Positives = 85/145 (58%), Gaps = 6/145 (4%) Query: 825 KDVQRCDRNYWYFTPA----NLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEA 880 KDV R DR + Y+ +L L +++ +Y H ++ Y QGM DL +P+L ++D E Sbjct: 290 KDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMDHEG 349 Query: 881 LAFSCFTELMKRMNQNF-PHGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYR 939 AF CF +MKR+ NF P G AM T FA+++ L++ D + ++ + + G +FCYR Sbjct: 350 HAFVCFCGIMKRLAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAG-ADDLFFCYR 408 Query: 940 WFLLDFKRELVYDDVFLVWETIWAA 964 W LL+ KRE +DD + E W++ Sbjct: 409 WLLLELKREFAFDDALRMLEVTWSS 433 Score = 44.7 bits (104), Expect = 5e-04 Identities = 22/50 (44%), Positives = 30/50 (60%), Gaps = 1/50 (2%) Query: 542 YLHDSTSYEEQELLRL-IYYGGIQPEIRKAVWPFLLGHYQFGMTETERKE 590 YL+ E LRL IY+GG++P +RK VW +LL Y G+T ER + Sbjct: 207 YLNHEGQLSRPEELRLRIYHGGVEPSLRKVVWRYLLNVYPDGLTGRERMD 256 Score = 40.4 bits (93), Expect = 0.009 Identities = 16/50 (32%), Positives = 33/50 (66%) Query: 972 YVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDL 1021 ++LF+ LA++ +RD I+ N +D+ ++ F+ + +H+ +VL+ AR L Sbjct: 617 FMLFLCLAILLEHRDHIMRNGLDYNELAMHFDRLVRKHHLGRVLRRARAL 666 >gi|34147456 TBC domain-containing protein kinase-like [Homo sapiens] Length = 830 Score = 63.2 bits (152), Expect = 1e-09 Identities = 46/191 (24%), Positives = 91/191 (47%), Gaps = 12/191 (6%) Query: 822 RIEKDVQRCDR-NYWYFTPANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVI-LDDE 879 +IE D+ RC + + +P K R ++ +++ H ++ Y QG+ L AP L + ++E Sbjct: 441 QIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLDSLCAPFLYLNFNNE 500 Query: 880 ALAFSCFTELMKRMNQNF---PHGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYF 936 ALA++C + + + NF + + + +I D EL +++ G Y Sbjct: 501 ALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELSNHLNEIGFIPDLY- 559 Query: 937 CYRWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFT 996 WFL F +F +W+T+ + ++ + I +A+++ RD +L N F Sbjct: 560 AIPWFLTMFTHVFPLHKIFHLWDTLL----LGNSSFPFCIGVAILQQLRDRLLANG--FN 613 Query: 997 DIIKFFNEMAE 1007 + I F+++ E Sbjct: 614 ECILLFSDLPE 624 >gi|222352143 TBC1 domain family, member 2 [Homo sapiens] Length = 917 Score = 58.2 bits (139), Expect = 4e-08 Identities = 40/143 (27%), Positives = 71/143 (49%), Gaps = 5/143 (3%) Query: 822 RIEKDVQRCDRNYWYFT-PANL--EKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDD 878 +IE D+ R N +FT P + +KLR ++ ++ WQ+ IGY QG+ L A L++L++ Sbjct: 669 QIELDLNRTFPNNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLEE 728 Query: 879 EALAFSCFTELMKRMNQNFPHGGAMDTHFANMRSLIQILDSELFELMHQNGDY--THFYF 936 E AF C +++ + + + + R L +L +L LM G + Sbjct: 729 EESAFWCLVAIVETIMPADYYCNTLTASQVDQRVLQDLLSEKLPRLMAHLGQHHVDLSLV 788 Query: 937 CYRWFLLDFKRELVYDDVFLVWE 959 + WFL+ F L+ + + VW+ Sbjct: 789 TFNWFLVVFADSLISNILLRVWD 811 Score = 31.2 bits (69), Expect = 5.3 Identities = 10/21 (47%), Positives = 17/21 (80%) Query: 537 RIWEQYLHDSTSYEEQELLRL 557 R+W+ +L++ T Y E+E+LRL Sbjct: 808 RVWDAFLYEGTKYNEKEILRL 828 >gi|109240556 RUN and FYVE domain-containing 2 isoform a [Homo sapiens] Length = 641 Score = 55.1 bits (131), Expect = 3e-07 Identities = 50/181 (27%), Positives = 82/181 (45%), Gaps = 30/181 (16%) Query: 1 MASAPAEAETRQRLLRTVKKEVKQIMEEAVT-RKFVHEDSSHIISFCAAVEACVLHGLRR 59 +A+ A R LL K +K ++E A++ + + D + F +E C+ HGL+ Sbjct: 36 LATKDPTAVERANLLNMAKLSIKGLIESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLKV 95 Query: 60 RAAGFLRSNK-IAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQENVRKLPKL 118 R + FL NK I V K +P AE++ V+DL L Sbjct: 96 RKS-FLSYNKTIWGPLELVEKLYPEAEEIGASVRDLPGL--------------------- 133 Query: 119 PNLSPLAIKHLWIRTALFEKVLDKIVHYLV---ENSSKYYEKEALLMDPVDGPILASLLV 175 +PL W+R AL +K + + L+ + S++YE AL+M+ +G ++ LLV Sbjct: 134 --KTPLGRARAWLRLALMQKKMADYLRCLIIQRDLLSEFYEYHALMMEE-EGAVIVGLLV 190 Query: 176 G 176 G Sbjct: 191 G 191 >gi|190014603 TBC1 domain family, member 13 [Homo sapiens] Length = 400 Score = 53.9 bits (128), Expect = 8e-07 Identities = 49/197 (24%), Positives = 89/197 (45%), Gaps = 21/197 (10%) Query: 840 ANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDD----------EALAFSCFTEL 889 A+ E + I+ Y + I YVQGM +++ PL EA F CFT L Sbjct: 206 AHWEVVERILFIYAKLNPGIAYVQGMNEIVGPLYYTFATDPNSEWKEHAEADTFFCFTNL 265 Query: 890 MKRMNQNFPHG-----GAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLD 944 M + NF + + S ++ D EL+ L Q + +F +RW L Sbjct: 266 MAEIRDNFIKSLDDSQCGITYKMEKVYSTLKDKDVELY-LKLQEQNIKPQFFAFRWLTLL 324 Query: 945 FKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDIIKFFNE 1004 +E + DV +W++++A + ++L + A++ + R+ +LE DFT ++ + Sbjct: 325 LSQEFLLPDVIRIWDSLFADD--NRFDFLLLVCCAMLMLIREQLLEG--DFTVNMRLLQD 380 Query: 1005 MAERHNTKQVLKLARDL 1021 + Q+L+ A++L Sbjct: 381 YPIT-DVCQILQKAKEL 396 >gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens] Length = 963 Score = 53.9 bits (128), Expect = 8e-07 Identities = 45/188 (23%), Positives = 88/188 (46%), Gaps = 12/188 (6%) Query: 822 RIEKDVQRC---DRNYWYFTPANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDD 878 +IE D+ R +++Y T ++KLRN++ ++ W++ +IGY QG+ L+A L+ L+ Sbjct: 709 QIELDLLRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALLYLEQ 768 Query: 879 EALAFSCFTELMKRMNQNFPHGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFY--F 936 E AF C +++ + + + R ++ +L L Y Y Sbjct: 769 ED-AFWCLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQYKVDYTLI 827 Query: 937 CYRWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDII--LENNMD 994 + WFL+ F +V D +F +W++ + ALAL + + I L+++M Sbjct: 828 TFNWFLVVFVDSVVSDILFKIWDSFL----YEGPKVIFRFALALFKYKEEEILKLQDSMS 883 Query: 995 FTDIIKFF 1002 +++F Sbjct: 884 IFKYLRYF 891 >gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens] Length = 914 Score = 53.9 bits (128), Expect = 8e-07 Identities = 45/188 (23%), Positives = 88/188 (46%), Gaps = 12/188 (6%) Query: 822 RIEKDVQRC---DRNYWYFTPANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDD 878 +IE D+ R +++Y T ++KLRN++ ++ W++ +IGY QG+ L+A L+ L+ Sbjct: 709 QIELDLLRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALLYLEQ 768 Query: 879 EALAFSCFTELMKRMNQNFPHGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFY--F 936 E AF C +++ + + + R ++ +L L Y Y Sbjct: 769 ED-AFWCLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQYKVDYTLI 827 Query: 937 CYRWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDII--LENNMD 994 + WFL+ F +V D +F +W++ + ALAL + + I L+++M Sbjct: 828 TFNWFLVVFVDSVVSDILFKIWDSFL----YEGPKVIFRFALALFKYKEEEILKLQDSMS 883 Query: 995 FTDIIKFF 1002 +++F Sbjct: 884 IFKYLRYF 891 >gi|148806902 TBC1 domain family, member 12 [Homo sapiens] Length = 775 Score = 53.5 bits (127), Expect = 1e-06 Identities = 61/248 (24%), Positives = 106/248 (42%), Gaps = 30/248 (12%) Query: 771 DNLSEEPEMESLFPALA-----SLAVTTSANEVSPVSSSGVTYSPELLDLYTVNLHRIEK 825 + L+ PE+ +F + A S + T+S N+ VS + S EL+ L Sbjct: 500 NELNITPELYEIFLSRAKERWKSFSETSSENDTEGVSVADREASLELIKL---------- 549 Query: 826 DVQRCDRNYWYFTPANL--EKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAF 883 D+ R + + F + L +I+ +Y ++GYVQGM +A +L++ +EA AF Sbjct: 550 DISRTFPSLYIFQKGGPYHDVLHSILGAYTCYRPDVGYVQGM-SFIAAVLILNLEEADAF 608 Query: 884 SCFTELMKRMNQ----NFPHGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYR 939 F L+ + Q H M +FA + S+LF L ++ T + Sbjct: 609 IAFANLLNKPCQLAFFRVDH-SMMLKYFATFEVFFEENLSKLF-LHFKSYSLTPDIYLID 666 Query: 940 WFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDII 999 W + + L D VW+ ++ L ++ +Y DI+L+ MDF I Sbjct: 667 WIFTLYSKSLPLDLACRVWDVFCR----DGEEFLFRTGLGILRLYEDILLQ--MDFIHIA 720 Query: 1000 KFFNEMAE 1007 +F ++ E Sbjct: 721 QFLTKLPE 728 >gi|94721330 RUN and FYVE domain-containing 1 isoform b [Homo sapiens] Length = 600 Score = 53.1 bits (126), Expect = 1e-06 Identities = 45/172 (26%), Positives = 82/172 (47%), Gaps = 28/172 (16%) Query: 9 ETRQRLLRTVKKEVKQIMEEAVTR-KFVHEDSSHIISFCAAVEACVLHGLRRRAAGFLRS 67 E R L+ +K +K +++ A++ + + D + + F +E C+ HGL+ + + F+ Sbjct: 3 EERANLMHMMKLSIKVLLQSALSLGRSLDADHAPLQQFFVVMEHCLKHGLKVKKS-FIGQ 61 Query: 68 NKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQENVRKLPKLPNLSPLAIK 127 NK F P E L+E + + +VR LP+L + + Sbjct: 62 NK---------SFFGPLE-----------LVEKLCPEASDIATSVRNLPELK--TAVGRG 99 Query: 128 HLWIRTALFEKVLDKIVHYLVENS---SKYYEKEALLMDPVDGPILASLLVG 176 W+ AL +K L + L++N S++YE EAL+M+ +G ++ LLVG Sbjct: 100 RAWLYLALMQKKLADYLKVLIDNKHLLSEFYEPEALMMEE-EGMVIVGLLVG 150 >gi|94721332 RUN and FYVE domain-containing 1 isoform b [Homo sapiens] Length = 600 Score = 53.1 bits (126), Expect = 1e-06 Identities = 45/172 (26%), Positives = 82/172 (47%), Gaps = 28/172 (16%) Query: 9 ETRQRLLRTVKKEVKQIMEEAVTR-KFVHEDSSHIISFCAAVEACVLHGLRRRAAGFLRS 67 E R L+ +K +K +++ A++ + + D + + F +E C+ HGL+ + + F+ Sbjct: 3 EERANLMHMMKLSIKVLLQSALSLGRSLDADHAPLQQFFVVMEHCLKHGLKVKKS-FIGQ 61 Query: 68 NKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQENVRKLPKLPNLSPLAIK 127 NK F P E L+E + + +VR LP+L + + Sbjct: 62 NK---------SFFGPLE-----------LVEKLCPEASDIATSVRNLPELK--TAVGRG 99 Query: 128 HLWIRTALFEKVLDKIVHYLVENS---SKYYEKEALLMDPVDGPILASLLVG 176 W+ AL +K L + L++N S++YE EAL+M+ +G ++ LLVG Sbjct: 100 RAWLYLALMQKKLADYLKVLIDNKHLLSEFYEPEALMMEE-EGMVIVGLLVG 150 >gi|94721336 RUN and FYVE domain-containing 1 isoform a [Homo sapiens] Length = 708 Score = 53.1 bits (126), Expect = 1e-06 Identities = 45/172 (26%), Positives = 82/172 (47%), Gaps = 28/172 (16%) Query: 9 ETRQRLLRTVKKEVKQIMEEAVTR-KFVHEDSSHIISFCAAVEACVLHGLRRRAAGFLRS 67 E R L+ +K +K +++ A++ + + D + + F +E C+ HGL+ + + F+ Sbjct: 111 EERANLMHMMKLSIKVLLQSALSLGRSLDADHAPLQQFFVVMEHCLKHGLKVKKS-FIGQ 169 Query: 68 NKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQENVRKLPKLPNLSPLAIK 127 NK F P E L+E + + +VR LP+L + + Sbjct: 170 NK---------SFFGPLE-----------LVEKLCPEASDIATSVRNLPELK--TAVGRG 207 Query: 128 HLWIRTALFEKVLDKIVHYLVENS---SKYYEKEALLMDPVDGPILASLLVG 176 W+ AL +K L + L++N S++YE EAL+M+ +G ++ LLVG Sbjct: 208 RAWLYLALMQKKLADYLKVLIDNKHLLSEFYEPEALMMEE-EGMVIVGLLVG 258 >gi|22507409 TBC1 domain family, member 22A [Homo sapiens] Length = 517 Score = 48.5 bits (114), Expect = 3e-05 Identities = 44/230 (19%), Positives = 91/230 (39%), Gaps = 28/230 (12%) Query: 822 RIEKDVQRCDRNYWYFTPANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVIL----- 876 +I D+ R P E I+ + +H GYVQG+ DL+ P V+ Sbjct: 279 QIHIDIPRMSPEALILQPKVTEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYI 338 Query: 877 -------------------DDEALAFSCFTELMKRMNQNFPHG-GAMDTHFANMRSLIQI 916 + EA + C ++L+ + N+ + + L+ Sbjct: 339 EAEEVDTVDVSGVPAEVLCNIEADTYWCMSKLLDGIQDNYTFAQPGIQMKVKMLEELVSR 398 Query: 917 LDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFI 976 +D ++ + Q+ + + F +RW RE+ +W+T + ++ +H+ L++ Sbjct: 399 IDEQVHRHLDQH-EVRYLQFAFRWMNNLLMREVPLRCTIRLWDT-YQSEPDGFSHFHLYV 456 Query: 977 ALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYKVQ 1026 A + +R ILE DF +++ F + H + + L Y+++ Sbjct: 457 CAAFLVRWRKEILEEK-DFQELLLFLQNLPTAHWDDEDISLLLAEAYRLK 505 >gi|164565381 TBC1 domain family, member 14 isoform b [Homo sapiens] Length = 413 Score = 48.5 bits (114), Expect = 3e-05 Identities = 47/195 (24%), Positives = 84/195 (43%), Gaps = 15/195 (7%) Query: 819 NLHRIEKDVQRCDRNYWYFTPANL--EKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVIL 876 +L I+ D+ R N F + L +I+ +Y ++GYVQGM +A +L++ Sbjct: 182 SLELIKLDISRTFPNLCIFQQGGPYHDMLHSILGAYTCYRPDVGYVQGM-SFIAAVLILN 240 Query: 877 DDEALAFSCFTELMKRMNQ----NFPHGGAMDTHFANMRSLIQILDSELFELMHQNGDYT 932 D A AF F+ L+ + Q H G M T+FA + +LF +N + T Sbjct: 241 LDTADAFIAFSNLLNKPCQMAFFRVDH-GLMLTYFAAFEVFFEENLPKLFAHFKKN-NLT 298 Query: 933 HFYFCYRWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENN 992 + W + + L D +W+ ++ AL +++++ DI+ Sbjct: 299 PDIYLIDWIFTLYSKSLPLDLACRIWDVFCR----DGEEFLFRTALGILKLFEDIL--TK 352 Query: 993 MDFTDIIKFFNEMAE 1007 MDF + +F + E Sbjct: 353 MDFIHMAQFLTRLPE 367 >gi|164565368 TBC1 domain family, member 14 isoform a [Homo sapiens] Length = 693 Score = 48.5 bits (114), Expect = 3e-05 Identities = 47/195 (24%), Positives = 84/195 (43%), Gaps = 15/195 (7%) Query: 819 NLHRIEKDVQRCDRNYWYFTPANL--EKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVIL 876 +L I+ D+ R N F + L +I+ +Y ++GYVQGM +A +L++ Sbjct: 462 SLELIKLDISRTFPNLCIFQQGGPYHDMLHSILGAYTCYRPDVGYVQGM-SFIAAVLILN 520 Query: 877 DDEALAFSCFTELMKRMNQ----NFPHGGAMDTHFANMRSLIQILDSELFELMHQNGDYT 932 D A AF F+ L+ + Q H G M T+FA + +LF +N + T Sbjct: 521 LDTADAFIAFSNLLNKPCQMAFFRVDH-GLMLTYFAAFEVFFEENLPKLFAHFKKN-NLT 578 Query: 933 HFYFCYRWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENN 992 + W + + L D +W+ ++ AL +++++ DI+ Sbjct: 579 PDIYLIDWIFTLYSKSLPLDLACRIWDVFCR----DGEEFLFRTALGILKLFEDIL--TK 632 Query: 993 MDFTDIIKFFNEMAE 1007 MDF + +F + E Sbjct: 633 MDFIHMAQFLTRLPE 647 >gi|164565366 TBC1 domain family, member 14 isoform a [Homo sapiens] Length = 693 Score = 48.5 bits (114), Expect = 3e-05 Identities = 47/195 (24%), Positives = 84/195 (43%), Gaps = 15/195 (7%) Query: 819 NLHRIEKDVQRCDRNYWYFTPANL--EKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVIL 876 +L I+ D+ R N F + L +I+ +Y ++GYVQGM +A +L++ Sbjct: 462 SLELIKLDISRTFPNLCIFQQGGPYHDMLHSILGAYTCYRPDVGYVQGM-SFIAAVLILN 520 Query: 877 DDEALAFSCFTELMKRMNQ----NFPHGGAMDTHFANMRSLIQILDSELFELMHQNGDYT 932 D A AF F+ L+ + Q H G M T+FA + +LF +N + T Sbjct: 521 LDTADAFIAFSNLLNKPCQMAFFRVDH-GLMLTYFAAFEVFFEENLPKLFAHFKKN-NLT 578 Query: 933 HFYFCYRWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENN 992 + W + + L D +W+ ++ AL +++++ DI+ Sbjct: 579 PDIYLIDWIFTLYSKSLPLDLACRIWDVFCR----DGEEFLFRTALGILKLFEDIL--TK 632 Query: 993 MDFTDIIKFFNEMAE 1007 MDF + +F + E Sbjct: 633 MDFIHMAQFLTRLPE 647 >gi|114688046 TBC1 domain family, member 4 [Homo sapiens] Length = 1298 Score = 44.3 bits (103), Expect = 6e-04 Identities = 50/214 (23%), Positives = 91/214 (42%), Gaps = 15/214 (7%) Query: 811 ELLDLYTVNLHRIEKDVQRCDRNYWYFT----PANLEKLRNIMCSYIWQHIEIGYVQGMC 866 ELL T H I D+ R + YF+ P L L N++ +Y E+GY QG+ Sbjct: 954 ELLKQLTAQQHAILVDLGRTFPTHPYFSVQLGPGQLS-LFNLLKAYSLLDKEVGYCQGIS 1012 Query: 867 DLLAPLLVILDDEALAFSCFTELMKRM---NQNFPHGGAMDTHFANMRSLIQILDSELFE 923 + LL+ + +E AF LM + Q P ++ + L+ +L+ Sbjct: 1013 FVAGVLLLHMSEEQ-AFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYN 1071 Query: 924 LMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEV 983 + +N + + + WFL F + V V++ I+ + + +AL+L+ Sbjct: 1072 HLEEN-EISPSLYAAPWFLTLFASQFSLGFVARVFDIIF----LQGTEVIFKVALSLLSS 1126 Query: 984 YRDIILENNMDFTDIIKFFNEMAERHNTKQVLKL 1017 +I+E F +I++F NT ++ K+ Sbjct: 1127 QETLIMECE-SFENIVEFLKNTLPDMNTSEMEKI 1159 >gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo sapiens] Length = 815 Score = 42.7 bits (99), Expect = 0.002 Identities = 73/332 (21%), Positives = 128/332 (38%), Gaps = 40/332 (12%) Query: 702 EATTSQDEAPREELAVQDS------LESDLLANESMDEFMSITGSLDMALPEKDDVVMEG 755 E + Q E+ +EE S + D ES +E S TG + PEK ++ Sbjct: 456 EVVSLQRESDKEEPVTPTSGGGPMSPQDDEAEEESDNELSSGTGDVSKDCPEK---ILYS 512 Query: 756 WRSSETEKHGQADSEDNLSEEPEMESLFPALASLAVTTSANEVSPVSSSGVTYSPELLDL 815 W + H NL P+ S L V + +G + +LD Sbjct: 513 WGELLGKWHS------NLGARPKGLS---TLVKSGVPEALRAEVWQLLAGCHDNQAMLDR 563 Query: 816 YTVNLHR-------IEKDVQRCDRNYWYFTPAN---LEKLRNIMCSYIWQHIEIGYVQGM 865 Y + + + I +D+ R + YF E L I +Y +IGY QG Sbjct: 564 YRILITKDSAQESVITRDIHRTFPAHDYFKDTGGDGQESLYKICKAYSVYDEDIGYCQGQ 623 Query: 866 CDLLAPLLVILDDEALAFSCFTELMKRMNQNFPHGGAMDTHFANMRSLIQILDSELFELM 925 L A LL+ + +E AF ++M + + L +++ +L +L Sbjct: 624 SFLAAVLLLHMPEEQ-AFCVLVKIMYDYGLRDLYRNNFEDLHCKFYQLERLMQEQLPDLH 682 Query: 926 HQNGDY---THFYFCYRWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVE 982 D H Y +WFL F + VF + + + + + +ALAL++ Sbjct: 683 SHFSDLNLEAHMY-ASQWFLTLFTAKFPLCMVFHIIDLLLC----EGLNIIFHVALALLK 737 Query: 983 VYRDIILENNMDFTDIIKFFN-EMAERHNTKQ 1013 ++ +L+ DF +KFF ++ +R+ ++ Sbjct: 738 TSKEDLLQ--ADFEGALKFFRVQLPKRYRAEE 767 >gi|197304777 TBC1 domain family, member 5 isoform a [Homo sapiens] Length = 817 Score = 41.6 bits (96), Expect = 0.004 Identities = 54/226 (23%), Positives = 93/226 (41%), Gaps = 60/226 (26%) Query: 823 IEKDVQRCDRNYWYFTPANLEK-LRNIMCSYIWQHIEIGYVQGMCDLLAPLLVIL--DDE 879 IE+DV+R +F N+ K L +++ Y ++ ++ Y QGM +LLAP++ +L D + Sbjct: 163 IEQDVKRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQ 222 Query: 880 AL-------------------------AFSCFTELMKRMN---QNFPHGGAMDTH----- 906 A A++ F++LM+ F H G Sbjct: 223 AFLHASESAQPSEEMKTVLNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMTP 282 Query: 907 --FANMRS-----------------LIQILDSELFELMHQNG-DYTHFYFCYRWFLLDFK 946 FA + L++ D EL+ MH N + + RW L F Sbjct: 283 IPFARPQDLGPTIAIVTKVNQIQDHLLKKHDIELY--MHLNRLEIAPQIYGLRWVRLLFG 340 Query: 947 RELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENN 992 RE D+ +VW+ ++A S V +I +A++ RD ++ +N Sbjct: 341 REFPLQDLLVVWDALFA--DGLSLGLVDYIFVAMLLYIRDALISSN 384 >gi|197304775 TBC1 domain family, member 5 isoform b [Homo sapiens] Length = 795 Score = 41.6 bits (96), Expect = 0.004 Identities = 54/226 (23%), Positives = 93/226 (41%), Gaps = 60/226 (26%) Query: 823 IEKDVQRCDRNYWYFTPANLEK-LRNIMCSYIWQHIEIGYVQGMCDLLAPLLVIL--DDE 879 IE+DV+R +F N+ K L +++ Y ++ ++ Y QGM +LLAP++ +L D + Sbjct: 163 IEQDVKRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQ 222 Query: 880 AL-------------------------AFSCFTELMKRMN---QNFPHGGAMDTH----- 906 A A++ F++LM+ F H G Sbjct: 223 AFLHASESAQPSEEMKTVLNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMTP 282 Query: 907 --FANMRS-----------------LIQILDSELFELMHQNG-DYTHFYFCYRWFLLDFK 946 FA + L++ D EL+ MH N + + RW L F Sbjct: 283 IPFARPQDLGPTIAIVTKVNQIQDHLLKKHDIELY--MHLNRLEIAPQIYGLRWVRLLFG 340 Query: 947 RELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENN 992 RE D+ +VW+ ++A S V +I +A++ RD ++ +N Sbjct: 341 REFPLQDLLVVWDALFA--DGLSLGLVDYIFVAMLLYIRDALISSN 384 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.317 0.132 0.393 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 40,255,317 Number of Sequences: 37866 Number of extensions: 1879181 Number of successful extensions: 7079 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 18 Number of HSP's successfully gapped in prelim test: 107 Number of HSP's that attempted gapping in prelim test: 6926 Number of HSP's gapped (non-prelim): 227 length of query: 1032 length of database: 18,247,518 effective HSP length: 112 effective length of query: 920 effective length of database: 14,006,526 effective search space: 12886003920 effective search space used: 12886003920 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.