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Search of human proteins with 14702164
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|14702164 nuclear receptor subfamily 1, group I, member 2
isoform 3 [Homo sapiens]
(397 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|14702164 nuclear receptor subfamily 1, group I, member 2 isof... 813 0.0
gi|34398348 nuclear receptor subfamily 1, group I, member 2 isof... 794 0.0
gi|11863132 nuclear receptor subfamily 1, group I, member 2 isof... 793 0.0
gi|4826661 constitutive androstane receptor isoform 3 [Homo sapi... 299 3e-81
gi|117938752 constitutive androstane receptor isoform 2 [Homo sa... 297 1e-80
gi|117938756 constitutive androstane receptor isoform 1 [Homo sa... 291 7e-79
gi|63054845 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo ... 289 3e-78
gi|4507883 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo s... 289 3e-78
gi|117938746 constitutive androstane receptor isoform 7 [Homo sa... 269 3e-72
gi|117938729 constitutive androstane receptor isoform 6 [Homo sa... 265 7e-71
gi|117938750 constitutive androstane receptor isoform 10 [Homo s... 248 9e-66
gi|117938754 constitutive androstane receptor isoform 4 [Homo sa... 245 4e-65
gi|117938734 constitutive androstane receptor isoform 5 [Homo sa... 244 1e-64
gi|117938736 constitutive androstane receptor isoform 9 [Homo sa... 241 6e-64
gi|117938748 constitutive androstane receptor isoform 14 [Homo s... 219 3e-57
gi|117938740 constitutive androstane receptor isoform 8 [Homo sa... 216 3e-56
gi|117938744 constitutive androstane receptor isoform 13 [Homo s... 213 2e-55
gi|117938738 constitutive androstane receptor isoform 12 [Homo s... 212 5e-55
gi|117938732 constitutive androstane receptor isoform 11 [Homo s... 193 3e-49
gi|194294519 nuclear receptor subfamily 1, group H, member 3 iso... 189 5e-48
gi|194294517 nuclear receptor subfamily 1, group H, member 3 iso... 189 5e-48
gi|85362735 nuclear receptor subfamily 1, group H, member 2 [Hom... 185 7e-47
gi|4826980 nuclear receptor subfamily 1, group H, member 4 [Homo... 178 9e-45
gi|189491771 thyroid hormone receptor, beta [Homo sapiens] 172 5e-43
gi|189491769 thyroid hormone receptor, beta [Homo sapiens] 172 5e-43
gi|40806162 thyroid hormone receptor, beta [Homo sapiens] 172 5e-43
gi|117938742 constitutive androstane receptor isoform 15 [Homo s... 165 8e-41
gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens] 159 5e-39
gi|40806160 thyroid hormone receptor, alpha isoform 1 [Homo sapi... 156 4e-38
gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens] 155 6e-38
>gi|14702164 nuclear receptor subfamily 1, group I, member 2 isoform
3 [Homo sapiens]
Length = 397
Score = 813 bits (2099), Expect = 0.0
Identities = 397/397 (100%), Positives = 397/397 (100%)
Query: 1 MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEG 60
MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEG
Sbjct: 1 MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEG 60
Query: 61 CKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEE 120
CKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEE
Sbjct: 61 CKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEE 120
Query: 121 RRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRVSLQLRG 180
RRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRVSLQLRG
Sbjct: 121 RRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRVSLQLRG 180
Query: 181 EDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLK 240
EDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLK
Sbjct: 181 EDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLK 240
Query: 241 GAAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHE 300
GAAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHE
Sbjct: 241 GAAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHE 300
Query: 301 EEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAML 360
EEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAML
Sbjct: 301 EEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAML 360
Query: 361 TELRSINAQHTQRLLRIQDIHPFATPLMQELFGITGS 397
TELRSINAQHTQRLLRIQDIHPFATPLMQELFGITGS
Sbjct: 361 TELRSINAQHTQRLLRIQDIHPFATPLMQELFGITGS 397
>gi|34398348 nuclear receptor subfamily 1, group I, member 2 isoform
1 [Homo sapiens]
Length = 434
Score = 794 bits (2051), Expect = 0.0
Identities = 397/434 (91%), Positives = 397/434 (91%), Gaps = 37/434 (8%)
Query: 1 MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEG 60
MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEG
Sbjct: 1 MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEG 60
Query: 61 CKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEE 120
CKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEE
Sbjct: 61 CKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEE 120
Query: 121 RRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFR------- 173
RRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFR
Sbjct: 121 RRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSS 180
Query: 174 ------------------------------VSLQLRGEDGSVWNYKPPADSGGKEIFSLL 203
VSLQLRGEDGSVWNYKPPADSGGKEIFSLL
Sbjct: 181 GCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLL 240
Query: 204 PHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWE 263
PHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWE
Sbjct: 241 PHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWE 300
Query: 264 CGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHR 323
CGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHR
Sbjct: 301 CGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHR 360
Query: 324 VVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPF 383
VVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPF
Sbjct: 361 VVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPF 420
Query: 384 ATPLMQELFGITGS 397
ATPLMQELFGITGS
Sbjct: 421 ATPLMQELFGITGS 434
>gi|11863132 nuclear receptor subfamily 1, group I, member 2 isoform
2 [Homo sapiens]
Length = 473
Score = 793 bits (2048), Expect = 0.0
Identities = 396/434 (91%), Positives = 397/434 (91%), Gaps = 37/434 (8%)
Query: 1 MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEG 60
+EVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEG
Sbjct: 40 LEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEG 99
Query: 61 CKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEE 120
CKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEE
Sbjct: 100 CKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEE 159
Query: 121 RRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFR------- 173
RRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFR
Sbjct: 160 RRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSS 219
Query: 174 ------------------------------VSLQLRGEDGSVWNYKPPADSGGKEIFSLL 203
VSLQLRGEDGSVWNYKPPADSGGKEIFSLL
Sbjct: 220 GCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLL 279
Query: 204 PHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWE 263
PHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWE
Sbjct: 280 PHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWE 339
Query: 264 CGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHR 323
CGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHR
Sbjct: 340 CGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHR 399
Query: 324 VVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPF 383
VVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPF
Sbjct: 400 VVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPF 459
Query: 384 ATPLMQELFGITGS 397
ATPLMQELFGITGS
Sbjct: 460 ATPLMQELFGITGS 473
>gi|4826661 constitutive androstane receptor isoform 3 [Homo
sapiens]
Length = 348
Score = 299 bits (765), Expect = 3e-81
Identities = 161/352 (45%), Positives = 223/352 (63%), Gaps = 17/352 (4%)
Query: 41 CRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLR 100
C VCGD+ATGYHFN +TCEGCKGFFRR + ++ CPF G+CE+++ RR C ACRL+
Sbjct: 11 CVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFA-GSCEVSKTQRRHCPACRLQ 69
Query: 101 KCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMK 160
KCL++GM+K+MI+S EA+ RRA ++++++T Q L++EQ +IR L+ A +
Sbjct: 70 KCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQ------LSKEQEELIRTLLGAHTR 123
Query: 161 TFDTTFSHFKNFRVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISF 220
T F F FR L + P + L+ H AD++T+M +I F
Sbjct: 124 HMGTMFEQFVQFRPPAHLFIHHQPLPTLAP--------VLPLVTHFADINTFMVLQVIKF 175
Query: 221 AKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAG-GFQ 279
K + FR LPIEDQISLLKGAA E+C + NT F +T + CG L Y +ED A GFQ
Sbjct: 176 TKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLRYTIEDGARVGFQ 235
Query: 280 QLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSY 339
LE + FH L+KLQL E EYVL+ A++LFSPDRPGV Q +DQLQE+ A+TL+SY
Sbjct: 236 VEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPDRPGVTQRDEIDQLQEEMALTLQSY 295
Query: 340 IECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQEL 391
I+ + +P RFL+ K++ +L ELRSIN + ++ IQ + PL+QE+
Sbjct: 296 IKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQGLSAM-MPLLQEI 346
>gi|117938752 constitutive androstane receptor isoform 2 [Homo
sapiens]
Length = 352
Score = 297 bits (761), Expect = 1e-80
Identities = 161/356 (45%), Positives = 223/356 (62%), Gaps = 21/356 (5%)
Query: 41 CRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLR 100
C VCGD+ATGYHFN +TCEGCKGFFRR + ++ CPF G+CE+++ RR C ACRL+
Sbjct: 11 CVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFA-GSCEVSKTQRRHCPACRLQ 69
Query: 101 KCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMK 160
KCL++GM+K+MI+S EA+ RRA ++++++T Q L++EQ +IR L+ A +
Sbjct: 70 KCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQ------LSKEQEELIRTLLGAHTR 123
Query: 161 TFDTTFSHFKNFRVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISF 220
T F F FR L + P + L+ H AD++T+M +I F
Sbjct: 124 HMGTMFEQFVQFRPPAHLFIHHQPLPTLAP--------VLPLVTHFADINTFMVLQVIKF 175
Query: 221 AKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAG---- 276
K + FR LPIEDQISLLKGAA E+C + NT F +T + CG L Y +ED A
Sbjct: 176 TKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLRYTIEDGARVSPT 235
Query: 277 -GFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAIT 335
GFQ LE + FH L+KLQL E EYVL+ A++LFSPDRPGV Q +DQLQE+ A+T
Sbjct: 236 VGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPDRPGVTQRDEIDQLQEEMALT 295
Query: 336 LKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQEL 391
L+SYI+ + +P RFL+ K++ +L ELRSIN + ++ IQ + PL+QE+
Sbjct: 296 LQSYIKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQGLSAM-MPLLQEI 350
>gi|117938756 constitutive androstane receptor isoform 1 [Homo
sapiens]
Length = 357
Score = 291 bits (745), Expect = 7e-79
Identities = 161/361 (44%), Positives = 223/361 (61%), Gaps = 26/361 (7%)
Query: 41 CRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLR 100
C VCGD+ATGYHFN +TCEGCKGFFRR + ++ CPF G+CE+++ RR C ACRL+
Sbjct: 11 CVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFA-GSCEVSKTQRRHCPACRLQ 69
Query: 101 KCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMK 160
KCL++GM+K+MI+S EA+ RRA ++++++T Q L++EQ +IR L+ A +
Sbjct: 70 KCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQ------LSKEQEELIRTLLGAHTR 123
Query: 161 TFDTTFSHFKNFRVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISF 220
T F F FR L + P + L+ H AD++T+M +I F
Sbjct: 124 HMGTMFEQFVQFRPPAHLFIHHQPLPTLAP--------VLPLVTHFADINTFMVLQVIKF 175
Query: 221 AKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAG---- 276
K + FR LPIEDQISLLKGAA E+C + NT F +T + CG L Y +ED A
Sbjct: 176 TKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLRYTIEDGARVSPT 235
Query: 277 -GFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSP-----DRPGVLQHRVVDQLQE 330
GFQ LE + FH L+KLQL E EYVL+ A++LFSP DRPGV Q +DQLQE
Sbjct: 236 VGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPAPYLTDRPGVTQRDEIDQLQE 295
Query: 331 QFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQE 390
+ A+TL+SYI+ + +P RFL+ K++ +L ELRSIN + ++ IQ + PL+QE
Sbjct: 296 EMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQGLSAM-MPLLQE 354
Query: 391 L 391
+
Sbjct: 355 I 355
>gi|63054845 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo
sapiens]
Length = 427
Score = 289 bits (740), Expect = 3e-78
Identities = 164/405 (40%), Positives = 230/405 (56%), Gaps = 51/405 (12%)
Query: 38 PQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQAC 97
P+IC VCGD+ATG+HFN MTCEGCKGFFRR+MKR A CPF G C IT+ RR CQAC
Sbjct: 21 PRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFN-GDCRITKDNRRHCQAC 79
Query: 98 RLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDA 157
RL++C++ GM KE I++DE V+ +R +I ++K E L + L+EEQ+ +I L+DA
Sbjct: 80 RLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPK-LSEEQQRIIAILLDA 138
Query: 158 QMKTFDTTFSHFKNFRVSLQLRGEDGS----VWNYKPPADSGGKEI-------------- 199
KT+D T+S F FR +++ GS + P+ SG
Sbjct: 139 HHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDMMD 198
Query: 200 -------------------------FSLLPHMADMSTYMFKGIISFAKVISYFRDLPIED 234
S+LPH+AD+ +Y + +I FAK+I FRDL ED
Sbjct: 199 SSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSED 258
Query: 235 QISLLKGAAFELCQLRFNTVFNAETGTWECGRLSY---CLEDTAGGFQQLLLEPMLKFHY 291
QI LLK +A E+ LR N F + +W CG Y + T G L+EP++KF
Sbjct: 259 QIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQV 318
Query: 292 MLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRF 351
LKKL LHEEE+VL+ AI + SPDRPGV +++ +Q++ + TL++YI C P P
Sbjct: 319 GLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHL 378
Query: 352 LFLKIMAMLTELRSINAQHTQ--RLLRIQ-DIHPFATPLMQELFG 393
L+ K++ L +LRS+N +H++ R L Q + TPL+ E+FG
Sbjct: 379 LYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVFG 423
>gi|4507883 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo
sapiens]
Length = 427
Score = 289 bits (740), Expect = 3e-78
Identities = 164/405 (40%), Positives = 230/405 (56%), Gaps = 51/405 (12%)
Query: 38 PQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQAC 97
P+IC VCGD+ATG+HFN MTCEGCKGFFRR+MKR A CPF G C IT+ RR CQAC
Sbjct: 21 PRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFN-GDCRITKDNRRHCQAC 79
Query: 98 RLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDA 157
RL++C++ GM KE I++DE V+ +R +I ++K E L + L+EEQ+ +I L+DA
Sbjct: 80 RLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPK-LSEEQQRIIAILLDA 138
Query: 158 QMKTFDTTFSHFKNFRVSLQLRGEDGS----VWNYKPPADSGGKEI-------------- 199
KT+D T+S F FR +++ GS + P+ SG
Sbjct: 139 HHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDMMD 198
Query: 200 -------------------------FSLLPHMADMSTYMFKGIISFAKVISYFRDLPIED 234
S+LPH+AD+ +Y + +I FAK+I FRDL ED
Sbjct: 199 SSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSED 258
Query: 235 QISLLKGAAFELCQLRFNTVFNAETGTWECGRLSY---CLEDTAGGFQQLLLEPMLKFHY 291
QI LLK +A E+ LR N F + +W CG Y + T G L+EP++KF
Sbjct: 259 QIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQV 318
Query: 292 MLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRF 351
LKKL LHEEE+VL+ AI + SPDRPGV +++ +Q++ + TL++YI C P P
Sbjct: 319 GLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHL 378
Query: 352 LFLKIMAMLTELRSINAQHTQ--RLLRIQ-DIHPFATPLMQELFG 393
L+ K++ L +LRS+N +H++ R L Q + TPL+ E+FG
Sbjct: 379 LYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVFG 423
>gi|117938746 constitutive androstane receptor isoform 7 [Homo
sapiens]
Length = 339
Score = 269 bits (688), Expect = 3e-72
Identities = 145/315 (46%), Positives = 197/315 (62%), Gaps = 20/315 (6%)
Query: 41 CRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLR 100
C VCGD+ATGYHFN +TCEGCKGFFRR + ++ CPF G+CE+++ RR C ACRL+
Sbjct: 11 CVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFA-GSCEVSKTQRRHCPACRLQ 69
Query: 101 KCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMK 160
KCL++GM+K+MI+S EA+ RRA ++++++T Q L++EQ +IR L+ A +
Sbjct: 70 KCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQ------LSKEQEELIRTLLGAHTR 123
Query: 161 TFDTTFSHFKNFRVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISF 220
T F F FR L + P + L+ H AD++T+M +I F
Sbjct: 124 HMGTMFEQFVQFRPPAHLFIHHQPLPTLAP--------VLPLVTHFADINTFMVLQVIKF 175
Query: 221 AKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAG---- 276
K + FR LPIEDQISLLKGAA E+C + NT F +T + CG L Y +ED A
Sbjct: 176 TKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLRYTIEDGARVSPT 235
Query: 277 -GFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAIT 335
GFQ LE + FH L+KLQL E EYVL+ A++LFSPDRPGV Q +DQLQE+ A+T
Sbjct: 236 VGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPDRPGVTQRDEIDQLQEEMALT 295
Query: 336 LKSYIECNRPQPAHR 350
L+SYI+ + +P R
Sbjct: 296 LQSYIKGQQRRPRDR 310
>gi|117938729 constitutive androstane receptor isoform 6 [Homo
sapiens]
Length = 340
Score = 265 bits (676), Expect = 7e-71
Identities = 145/316 (45%), Positives = 197/316 (62%), Gaps = 21/316 (6%)
Query: 41 CRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLR 100
C VCGD+ATGYHFN +TCEGCKGFFRR + ++ CPF G+CE+++ RR C ACRL+
Sbjct: 11 CVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFA-GSCEVSKTQRRHCPACRLQ 69
Query: 101 KCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMK 160
KCL++GM+K+MI+S EA+ RRA ++++++T Q L++EQ +IR L+ A +
Sbjct: 70 KCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQ------LSKEQEELIRTLLGAHTR 123
Query: 161 TFDTTFSHFKNFRVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISF 220
T F F FR L + P + L+ H AD++T+M +I F
Sbjct: 124 HMGTMFEQFVQFRPPAHLFIHHQPLPTLAP--------VLPLVTHFADINTFMVLQVIKF 175
Query: 221 AKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAG-GFQ 279
K + FR LPIEDQISLLKGAA E+C + NT F +T + CG L Y +ED A GFQ
Sbjct: 176 TKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLRYTIEDGARVGFQ 235
Query: 280 QLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSP-----DRPGVLQHRVVDQLQEQFAI 334
LE + FH L+KLQL E EYVL+ A++LFSP DRPGV Q +DQLQE+ A+
Sbjct: 236 VEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPAPYLTDRPGVTQRDEIDQLQEEMAL 295
Query: 335 TLKSYIECNRPQPAHR 350
TL+SYI+ + +P R
Sbjct: 296 TLQSYIKGQQRRPRDR 311
>gi|117938750 constitutive androstane receptor isoform 10 [Homo
sapiens]
Length = 319
Score = 248 bits (632), Expect = 9e-66
Identities = 140/327 (42%), Positives = 200/327 (61%), Gaps = 17/327 (5%)
Query: 66 RRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALI 125
RR + ++ CPF G+CE+++ RR C ACRL+KCL++GM+K+MI+S EA+ RRA
Sbjct: 7 RRTVSKSIGPTCPFA-GSCEVSKTQRRHCPACRLQKCLDAGMRKDMILSAEALALRRAKQ 65
Query: 126 KRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRVSLQLRGEDGSV 185
++++++T Q L++EQ +IR L+ A + T F F FR L +
Sbjct: 66 AQRRAQQTPVQ------LSKEQEELIRTLLGAHTRHMGTMFEQFVQFRPPAHLFIHHQPL 119
Query: 186 WNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFE 245
P + L+ H AD++T+M +I F K + FR LPIEDQISLLKGAA E
Sbjct: 120 PTLAP--------VLPLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVE 171
Query: 246 LCQLRFNTVFNAETGTWECGRLSYCLEDTAG-GFQQLLLEPMLKFHYMLKKLQLHEEEYV 304
+C + NT F +T + CG L Y +ED A GFQ LE + FH L+KLQL E EYV
Sbjct: 172 ICHIVLNTTFCLQTQNFLCGPLRYTIEDGARVGFQVEFLELLFHFHGTLRKLQLQEPEYV 231
Query: 305 LMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELR 364
L+ A++LFSPDRPGV Q +DQLQE+ A+TL+SYI+ + +P RFL+ K++ +L ELR
Sbjct: 232 LLAAMALFSPDRPGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELR 291
Query: 365 SINAQHTQRLLRIQDIHPFATPLMQEL 391
SIN + ++ IQ + PL+QE+
Sbjct: 292 SINEAYGYQIQHIQGLSAM-MPLLQEI 317
>gi|117938754 constitutive androstane receptor isoform 4 [Homo
sapiens]
Length = 314
Score = 245 bits (626), Expect = 4e-65
Identities = 139/351 (39%), Positives = 198/351 (56%), Gaps = 49/351 (13%)
Query: 41 CRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLR 100
C VCGD+ATGYHFN +TCEGCKGFFRR + ++ CPF G+CE+++ RR C ACRL+
Sbjct: 11 CVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFA-GSCEVSKTQRRHCPACRLQ 69
Query: 101 KCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMK 160
KCL++GM+K+MI+S EA+ RRA ++++++T Q L++EQ +IR L+ A +
Sbjct: 70 KCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQ------LSKEQEELIRTLLGAHTR 123
Query: 161 TFDTTFSHFKNFRVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISF 220
T F F FR L + P + L+ H AD++T+M +I F
Sbjct: 124 HMGTMFEQFVQFRPPAHLFIHHQPLPTLAP--------VLPLVTHFADINTFMVLQVIKF 175
Query: 221 AKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQ 280
K + FR LPIEDQISLLKGAA E+C + NT F +T + CG L Y +ED A
Sbjct: 176 TKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLRYTIEDGAR---- 231
Query: 281 LLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYI 340
+ + DRPGV Q +DQLQE+ A+TL+SYI
Sbjct: 232 -----------------------------APYLTDRPGVTQRDEIDQLQEEMALTLQSYI 262
Query: 341 ECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQEL 391
+ + +P RFL+ K++ +L ELRSIN + ++ IQ + PL+QE+
Sbjct: 263 KGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQGLSAM-MPLLQEI 312
>gi|117938734 constitutive androstane receptor isoform 5 [Homo
sapiens]
Length = 309
Score = 244 bits (623), Expect = 1e-64
Identities = 139/351 (39%), Positives = 196/351 (55%), Gaps = 54/351 (15%)
Query: 41 CRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLR 100
C VCGD+ATGYHFN +TCEGCKGFFRR + ++ CPF G+CE+++ RR C ACRL+
Sbjct: 11 CVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFA-GSCEVSKTQRRHCPACRLQ 69
Query: 101 KCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMK 160
KCL++GM+K+MI+S EA+ RRA ++++++T Q L++EQ +IR L+ A +
Sbjct: 70 KCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQ------LSKEQEELIRTLLGAHTR 123
Query: 161 TFDTTFSHFKNFRVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISF 220
T F F FR L + P + L+ H AD++T+M +I F
Sbjct: 124 HMGTMFEQFVQFRPPAHLFIHHQPLPTLAP--------VLPLVTHFADINTFMVLQVIKF 175
Query: 221 AKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQ 280
K + FR LPIEDQISLLKGAA E+C + NT F +T + CG L Y +ED A
Sbjct: 176 TKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLRYTIEDGA----- 230
Query: 281 LLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYI 340
DRPGV Q +DQLQE+ A+TL+SYI
Sbjct: 231 ---------------------------------RDRPGVTQRDEIDQLQEEMALTLQSYI 257
Query: 341 ECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQEL 391
+ + +P RFL+ K++ +L ELRSIN + ++ IQ + PL+QE+
Sbjct: 258 KGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQGLSAM-MPLLQEI 307
>gi|117938736 constitutive androstane receptor isoform 9 [Homo
sapiens]
Length = 324
Score = 241 bits (616), Expect = 6e-64
Identities = 140/332 (42%), Positives = 200/332 (60%), Gaps = 22/332 (6%)
Query: 66 RRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALI 125
RR + ++ CPF G+CE+++ RR C ACRL+KCL++GM+K+MI+S EA+ RRA
Sbjct: 7 RRTVSKSIGPTCPFA-GSCEVSKTQRRHCPACRLQKCLDAGMRKDMILSAEALALRRAKQ 65
Query: 126 KRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRVSLQLRGEDGSV 185
++++++T Q L++EQ +IR L+ A + T F F FR L +
Sbjct: 66 AQRRAQQTPVQ------LSKEQEELIRTLLGAHTRHMGTMFEQFVQFRPPAHLFIHHQPL 119
Query: 186 WNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFE 245
P + L+ H AD++T+M +I F K + FR LPIEDQISLLKGAA E
Sbjct: 120 PTLAP--------VLPLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVE 171
Query: 246 LCQLRFNTVFNAETGTWECGRLSYCLEDTAG-GFQQLLLEPMLKFHYMLKKLQLHEEEYV 304
+C + NT F +T + CG L Y +ED A GFQ LE + FH L+KLQL E EYV
Sbjct: 172 ICHIVLNTTFCLQTQNFLCGPLRYTIEDGARVGFQVEFLELLFHFHGTLRKLQLQEPEYV 231
Query: 305 LMQAISLFSP-----DRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAM 359
L+ A++LFSP DRPGV Q +DQLQE+ A+TL+SYI+ + +P RFL+ K++ +
Sbjct: 232 LLAAMALFSPAPYLTDRPGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLGL 291
Query: 360 LTELRSINAQHTQRLLRIQDIHPFATPLMQEL 391
L ELRSIN + ++ IQ + PL+QE+
Sbjct: 292 LAELRSINEAYGYQIQHIQGLSAM-MPLLQEI 322
>gi|117938748 constitutive androstane receptor isoform 14 [Homo
sapiens]
Length = 306
Score = 219 bits (559), Expect = 3e-57
Identities = 124/286 (43%), Positives = 174/286 (60%), Gaps = 16/286 (5%)
Query: 66 RRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALI 125
RR + ++ CPF G+CE+++ RR C ACRL+KCL++GM+K+MI+S EA+ RRA
Sbjct: 7 RRTVSKSIGPTCPFA-GSCEVSKTQRRHCPACRLQKCLDAGMRKDMILSAEALALRRAKQ 65
Query: 126 KRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRVSLQLRGEDGSV 185
++++++T Q L++EQ +IR L+ A + T F F FR L +
Sbjct: 66 AQRRAQQTPVQ------LSKEQEELIRTLLGAHTRHMGTMFEQFVQFRPPAHLFIHHQPL 119
Query: 186 WNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFE 245
P + L+ H AD++T+M +I F K + FR LPIEDQISLLKGAA E
Sbjct: 120 PTLAP--------VLPLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVE 171
Query: 246 LCQLRFNTVFNAETGTWECGRLSYCLEDTAG-GFQQLLLEPMLKFHYMLKKLQLHEEEYV 304
+C + NT F +T + CG L Y +ED A GFQ LE + FH L+KLQL E EYV
Sbjct: 172 ICHIVLNTTFCLQTQNFLCGPLRYTIEDGARVGFQVEFLELLFHFHGTLRKLQLQEPEYV 231
Query: 305 LMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHR 350
L+ A++LFSPDRPGV Q +DQLQE+ A+TL+SYI+ + +P R
Sbjct: 232 LLAAMALFSPDRPGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDR 277
>gi|117938740 constitutive androstane receptor isoform 8 [Homo
sapiens]
Length = 296
Score = 216 bits (550), Expect = 3e-56
Identities = 123/310 (39%), Positives = 170/310 (54%), Gaps = 53/310 (17%)
Query: 41 CRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLR 100
C VCGD+ATGYHFN +TCEGCKGFFRR + ++ CPF G+CE+++ RR C ACRL+
Sbjct: 11 CVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFA-GSCEVSKTQRRHCPACRLQ 69
Query: 101 KCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMK 160
KCL++GM+K+MI+S EA+ RRA ++++++T Q L++EQ +IR L+ A +
Sbjct: 70 KCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQ------LSKEQEELIRTLLGAHTR 123
Query: 161 TFDTTFSHFKNFRVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISF 220
T F F FR L + P + L+ H AD++T+M +I F
Sbjct: 124 HMGTMFEQFVQFRPPAHLFIHHQPLPTLAP--------VLPLVTHFADINTFMVLQVIKF 175
Query: 221 AKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQ 280
K + FR LPIEDQISLLKGAA E+C + NT F +T + CG L Y +ED A
Sbjct: 176 TKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLRYTIEDGA----- 230
Query: 281 LLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYI 340
DRPGV Q +DQLQE+ A+TL+SYI
Sbjct: 231 ---------------------------------RDRPGVTQRDEIDQLQEEMALTLQSYI 257
Query: 341 ECNRPQPAHR 350
+ + +P R
Sbjct: 258 KGQQRRPRDR 267
>gi|117938744 constitutive androstane receptor isoform 13 [Homo
sapiens]
Length = 311
Score = 213 bits (543), Expect = 2e-55
Identities = 124/291 (42%), Positives = 174/291 (59%), Gaps = 21/291 (7%)
Query: 66 RRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALI 125
RR + ++ CPF G+CE+++ RR C ACRL+KCL++GM+K+MI+S EA+ RRA
Sbjct: 7 RRTVSKSIGPTCPFA-GSCEVSKTQRRHCPACRLQKCLDAGMRKDMILSAEALALRRAKQ 65
Query: 126 KRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRVSLQLRGEDGSV 185
++++++T Q L++EQ +IR L+ A + T F F FR L +
Sbjct: 66 AQRRAQQTPVQ------LSKEQEELIRTLLGAHTRHMGTMFEQFVQFRPPAHLFIHHQPL 119
Query: 186 WNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFE 245
P + L+ H AD++T+M +I F K + FR LPIEDQISLLKGAA E
Sbjct: 120 PTLAP--------VLPLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVE 171
Query: 246 LCQLRFNTVFNAETGTWECGRLSYCLEDTAG-GFQQLLLEPMLKFHYMLKKLQLHEEEYV 304
+C + NT F +T + CG L Y +ED A GFQ LE + FH L+KLQL E EYV
Sbjct: 172 ICHIVLNTTFCLQTQNFLCGPLRYTIEDGARVGFQVEFLELLFHFHGTLRKLQLQEPEYV 231
Query: 305 LMQAISLFSP-----DRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHR 350
L+ A++LFSP DRPGV Q +DQLQE+ A+TL+SYI+ + +P R
Sbjct: 232 LLAAMALFSPAPYLTDRPGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDR 282
>gi|117938738 constitutive androstane receptor isoform 12 [Homo
sapiens]
Length = 315
Score = 212 bits (539), Expect = 5e-55
Identities = 124/295 (42%), Positives = 174/295 (58%), Gaps = 25/295 (8%)
Query: 66 RRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALI 125
RR + ++ CPF G+CE+++ RR C ACRL+KCL++GM+K+MI+S EA+ RRA
Sbjct: 7 RRTVSKSIGPTCPFA-GSCEVSKTQRRHCPACRLQKCLDAGMRKDMILSAEALALRRAKQ 65
Query: 126 KRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRVSLQLRGEDGSV 185
++++++T Q L++EQ +IR L+ A + T F F FR L +
Sbjct: 66 AQRRAQQTPVQ------LSKEQEELIRTLLGAHTRHMGTMFEQFVQFRPPAHLFIHHQPL 119
Query: 186 WNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFE 245
P + L+ H AD++T+M +I F K + FR LPIEDQISLLKGAA E
Sbjct: 120 PTLAP--------VLPLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVE 171
Query: 246 LCQLRFNTVFNAETGTWECGRLSYCLEDTAG-----GFQQLLLEPMLKFHYMLKKLQLHE 300
+C + NT F +T + CG L Y +ED A GFQ LE + FH L+KLQL E
Sbjct: 172 ICHIVLNTTFCLQTQNFLCGPLRYTIEDGARVSPTVGFQVEFLELLFHFHGTLRKLQLQE 231
Query: 301 EEYVLMQAISLFSP-----DRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHR 350
EYVL+ A++LFSP DRPGV Q +DQLQE+ A+TL+SYI+ + +P R
Sbjct: 232 PEYVLLAAMALFSPAPYLTDRPGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDR 286
>gi|117938732 constitutive androstane receptor isoform 11 [Homo
sapiens]
Length = 280
Score = 193 bits (490), Expect = 3e-49
Identities = 118/326 (36%), Positives = 173/326 (53%), Gaps = 54/326 (16%)
Query: 66 RRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALI 125
RR + ++ CPF G+CE+++ RR C ACRL+KCL++GM+K+MI+S EA+ RRA
Sbjct: 7 RRTVSKSIGPTCPFA-GSCEVSKTQRRHCPACRLQKCLDAGMRKDMILSAEALALRRAKQ 65
Query: 126 KRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRVSLQLRGEDGSV 185
++++++T Q L++EQ +IR L+ A + T F F FR L +
Sbjct: 66 AQRRAQQTPVQ------LSKEQEELIRTLLGAHTRHMGTMFEQFVQFRPPAHLFIHHQPL 119
Query: 186 WNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFE 245
P + L+ H AD++T+M +I F K + FR LPIEDQISLLKGAA E
Sbjct: 120 PTLAP--------VLPLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVE 171
Query: 246 LCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVL 305
+C + NT F +T + CG L Y +ED A
Sbjct: 172 ICHIVLNTTFCLQTQNFLCGPLRYTIEDGA------------------------------ 201
Query: 306 MQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRS 365
DRPGV Q +DQLQE+ A+TL+SYI+ + +P RFL+ K++ +L ELRS
Sbjct: 202 --------RDRPGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRS 253
Query: 366 INAQHTQRLLRIQDIHPFATPLMQEL 391
IN + ++ IQ + PL+QE+
Sbjct: 254 INEAYGYQIQHIQGLSAM-MPLLQEI 278
>gi|194294519 nuclear receptor subfamily 1, group H, member 3
isoform c [Homo sapiens]
Length = 402
Score = 189 bits (479), Expect = 5e-48
Identities = 128/391 (32%), Positives = 214/391 (54%), Gaps = 34/391 (8%)
Query: 18 EDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRC 77
E TE P K ++ G ++C VCGDKA+G+H+NV++CEGCKGFFRR++ + A C
Sbjct: 30 EPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYIC 89
Query: 78 PFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSE------ 131
G C + RR+CQ CRLRKC ++GM++E ++S+E + ++ +KR++ E
Sbjct: 90 -HSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKK--LKRQEEEQAHATS 146
Query: 132 ---RTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRVSLQLRGEDGSVWNY 188
R + P + L+ EQ MI +L+ AQ + +FS RV+ D
Sbjct: 147 LPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFS--DRLRVTPWPMAPD------ 198
Query: 189 KPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQ 248
P + ++ F+ H +++ + I+ FAK + F L EDQI+LLK +A E+
Sbjct: 199 -PHSREARQQRFA---HFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVML 254
Query: 249 LRFNTVFN--AETGTWECGRLSYCLEDTA-GGFQQLLLEPMLKFHYMLKKLQLHEEEYVL 305
L + +N +E+ T+ SY ED A G Q + P+ +F + +LQL++ E+ L
Sbjct: 255 LETSRRYNPGSESITF-LKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFAL 313
Query: 306 MQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRS 365
+ AIS+FS DRP V V++LQ + L +Y+ + P R +F +++ L LR+
Sbjct: 314 LIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPH--DRLMFPRMLMKLVSLRT 371
Query: 366 INAQHTQRL--LRIQDIHPFATPLMQELFGI 394
+++ H++++ LR+QD PL+ E++ +
Sbjct: 372 LSSVHSEQVFALRLQD--KKLPPLLSEIWDV 400
>gi|194294517 nuclear receptor subfamily 1, group H, member 3
isoform a [Homo sapiens]
Length = 447
Score = 189 bits (479), Expect = 5e-48
Identities = 128/391 (32%), Positives = 214/391 (54%), Gaps = 34/391 (8%)
Query: 18 EDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRC 77
E TE P K ++ G ++C VCGDKA+G+H+NV++CEGCKGFFRR++ + A C
Sbjct: 75 EPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYIC 134
Query: 78 PFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSE------ 131
G C + RR+CQ CRLRKC ++GM++E ++S+E + ++ +KR++ E
Sbjct: 135 -HSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKK--LKRQEEEQAHATS 191
Query: 132 ---RTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRVSLQLRGEDGSVWNY 188
R + P + L+ EQ MI +L+ AQ + +FS RV+ D
Sbjct: 192 LPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFS--DRLRVTPWPMAPD------ 243
Query: 189 KPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQ 248
P + ++ F+ H +++ + I+ FAK + F L EDQI+LLK +A E+
Sbjct: 244 -PHSREARQQRFA---HFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVML 299
Query: 249 LRFNTVFN--AETGTWECGRLSYCLEDTA-GGFQQLLLEPMLKFHYMLKKLQLHEEEYVL 305
L + +N +E+ T+ SY ED A G Q + P+ +F + +LQL++ E+ L
Sbjct: 300 LETSRRYNPGSESITF-LKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFAL 358
Query: 306 MQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRS 365
+ AIS+FS DRP V V++LQ + L +Y+ + P R +F +++ L LR+
Sbjct: 359 LIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPH--DRLMFPRMLMKLVSLRT 416
Query: 366 INAQHTQRL--LRIQDIHPFATPLMQELFGI 394
+++ H++++ LR+QD PL+ E++ +
Sbjct: 417 LSSVHSEQVFALRLQD--KKLPPLLSEIWDV 445
>gi|85362735 nuclear receptor subfamily 1, group H, member 2 [Homo
sapiens]
Length = 461
Score = 185 bits (469), Expect = 7e-47
Identities = 125/396 (31%), Positives = 211/396 (53%), Gaps = 57/396 (14%)
Query: 37 GPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGA-CEITRKTRRQCQ 95
G ++CRVCGDKA+G+H+NV++CEGCKGFFRR++ R R R G C++ RR+CQ
Sbjct: 83 GHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQ 142
Query: 96 ACRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQ-PLGVQG------------ 142
CRLRKC E+GM+++ ++S+E + +++ ++++ ++ +Q P+G QG
Sbjct: 143 QCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQQESQSQSQSPVGPQGSSSSASGPGASP 202
Query: 143 -----------------LTEEQRMMIRELMDAQMKTFDTTFSHFKNFRVSLQLRGEDGSV 185
LT Q +MI++L+ AQ++ +FS +V+ G D
Sbjct: 203 GGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQP--KVTPWPLGAD--- 257
Query: 186 WNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFE 245
P + ++ F+ H +++ + I+ FAK + F L EDQI+LLK + E
Sbjct: 258 ----PQSRDARQQRFA---HFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIE 310
Query: 246 LCQLRFNTVFNAETGTWEC----GRLSYCLEDT-AGGFQQLLLEPMLKFHYMLKKLQLHE 300
+ L +N ET EC +Y +D G Q + P+ +F +++L L +
Sbjct: 311 IMLLETARRYNHET---ECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDD 367
Query: 301 EEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAML 360
EY L+ AI++FS DRP V + V+ LQ+ + L SY RPQ R F +++ L
Sbjct: 368 AEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLR--FPRMLMKL 425
Query: 361 TELRSINAQHTQRL--LRIQDIHPFATPLMQELFGI 394
LR++++ H++++ LR+QD PL+ E++ +
Sbjct: 426 VSLRTLSSVHSEQVFALRLQD--KKLPPLLSEIWDV 459
>gi|4826980 nuclear receptor subfamily 1, group H, member 4 [Homo
sapiens]
Length = 472
Score = 178 bits (451), Expect = 9e-45
Identities = 122/380 (32%), Positives = 197/380 (51%), Gaps = 24/380 (6%)
Query: 23 VPGKPSVNADE-EVGGPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRK 81
V KP + A + G ++C VCGD+A+GYH+N +TCEGCKGFFRR++ +NA +C
Sbjct: 108 VTKKPRMGASAGRIKGDELCVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCK-NG 166
Query: 82 GACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQ 141
G C + RR+CQ CRLRKC E GM E ++++ + +R RK ++ Q +
Sbjct: 167 GNCVMDMYMRRKCQECRLRKCKEMGMLAECLLTEIQCKSKRL---RKNVKQHADQTVNED 223
Query: 142 GLTEEQRMMIRELMDAQMKTFDT----TFSHFKNFRVSLQLRGEDGSVWNYKPPADSGGK 197
+ R + + KT T T HF + Q ++ + N + +
Sbjct: 224 SEGRDLRQVTSTTKSCREKTELTPDQQTLLHFIMDSYNKQRMPQE--ITNKILKEEFSAE 281
Query: 198 EIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNA 257
E F +L +M+T + ++ F K + F+ L EDQI+LLKG+A E LR +FN
Sbjct: 282 ENFLIL---TEMATNHVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNK 338
Query: 258 ETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRP 317
+ + L + ++ G + PM F+ + +L++ +EEY L+ AI + SPDR
Sbjct: 339 KLPSGHSDLLEERIRNS--GISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQ 396
Query: 318 GVLQHRVVDQLQEQFAITLKSYIECNRPQ-PAHRFLFLKIMAMLTELRSINAQHTQRLL- 375
+ V++LQE L+ + ++P+ P H F ++ LTELR+ N H + L+
Sbjct: 397 YIKDREAVEKLQEPLLDVLQKLCKIHQPENPQH---FACLLGRLTELRTFNHHHAEMLMS 453
Query: 376 -RIQDIHPFATPLMQELFGI 394
R+ D H F TPL+ E++ +
Sbjct: 454 WRVND-HKF-TPLLCEIWDV 471
>gi|189491771 thyroid hormone receptor, beta [Homo sapiens]
Length = 461
Score = 172 bits (436), Expect = 5e-43
Identities = 113/363 (31%), Positives = 178/363 (49%), Gaps = 17/363 (4%)
Query: 39 QICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNAR--LRCPFRKGACEITRKTRRQCQA 96
++C VCGDKATGYH+ +TCEGCKGFFRR +++N C + +G C I + TR QCQ
Sbjct: 105 ELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKY-EGKCVIDKVTRNQCQE 163
Query: 97 CRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQG----LTEEQRMMIR 152
CR +KC+ GM ++++ D +R LI+ + +R + G T+E+ +I+
Sbjct: 164 CRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIK 223
Query: 153 ELMDAQMKTFDTTFSHFKNFRVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTY 212
+ +A + T + SH+K R L + N A GGK H + T
Sbjct: 224 TVTEAHVAT-NAQGSHWKQKRKFLPEDIGQAPIVN----APEGGKVDLEAFSHFTKIITP 278
Query: 213 MFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWEC-GRLSYCL 271
++ FAK + F +LP EDQI LLKG E+ LR ++ E+ T G ++
Sbjct: 279 AITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTR 338
Query: 272 EDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQ 331
G ++ + + L L + E L+QA+ L S DRPG+ +++ Q+
Sbjct: 339 GQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDS 398
Query: 332 FAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHP--FATPLMQ 389
F + + YI + H + K++ +T+LR I A H R L ++ P PL
Sbjct: 399 FLLAFEHYINYRKHHVTH--FWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFL 456
Query: 390 ELF 392
E+F
Sbjct: 457 EVF 459
>gi|189491769 thyroid hormone receptor, beta [Homo sapiens]
Length = 461
Score = 172 bits (436), Expect = 5e-43
Identities = 113/363 (31%), Positives = 178/363 (49%), Gaps = 17/363 (4%)
Query: 39 QICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNAR--LRCPFRKGACEITRKTRRQCQA 96
++C VCGDKATGYH+ +TCEGCKGFFRR +++N C + +G C I + TR QCQ
Sbjct: 105 ELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKY-EGKCVIDKVTRNQCQE 163
Query: 97 CRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQG----LTEEQRMMIR 152
CR +KC+ GM ++++ D +R LI+ + +R + G T+E+ +I+
Sbjct: 164 CRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIK 223
Query: 153 ELMDAQMKTFDTTFSHFKNFRVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTY 212
+ +A + T + SH+K R L + N A GGK H + T
Sbjct: 224 TVTEAHVAT-NAQGSHWKQKRKFLPEDIGQAPIVN----APEGGKVDLEAFSHFTKIITP 278
Query: 213 MFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWEC-GRLSYCL 271
++ FAK + F +LP EDQI LLKG E+ LR ++ E+ T G ++
Sbjct: 279 AITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTR 338
Query: 272 EDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQ 331
G ++ + + L L + E L+QA+ L S DRPG+ +++ Q+
Sbjct: 339 GQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDS 398
Query: 332 FAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHP--FATPLMQ 389
F + + YI + H + K++ +T+LR I A H R L ++ P PL
Sbjct: 399 FLLAFEHYINYRKHHVTH--FWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFL 456
Query: 390 ELF 392
E+F
Sbjct: 457 EVF 459
>gi|40806162 thyroid hormone receptor, beta [Homo sapiens]
Length = 461
Score = 172 bits (436), Expect = 5e-43
Identities = 113/363 (31%), Positives = 178/363 (49%), Gaps = 17/363 (4%)
Query: 39 QICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNAR--LRCPFRKGACEITRKTRRQCQA 96
++C VCGDKATGYH+ +TCEGCKGFFRR +++N C + +G C I + TR QCQ
Sbjct: 105 ELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKY-EGKCVIDKVTRNQCQE 163
Query: 97 CRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQG----LTEEQRMMIR 152
CR +KC+ GM ++++ D +R LI+ + +R + G T+E+ +I+
Sbjct: 164 CRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIK 223
Query: 153 ELMDAQMKTFDTTFSHFKNFRVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTY 212
+ +A + T + SH+K R L + N A GGK H + T
Sbjct: 224 TVTEAHVAT-NAQGSHWKQKRKFLPEDIGQAPIVN----APEGGKVDLEAFSHFTKIITP 278
Query: 213 MFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWEC-GRLSYCL 271
++ FAK + F +LP EDQI LLKG E+ LR ++ E+ T G ++
Sbjct: 279 AITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTR 338
Query: 272 EDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQ 331
G ++ + + L L + E L+QA+ L S DRPG+ +++ Q+
Sbjct: 339 GQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDS 398
Query: 332 FAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHP--FATPLMQ 389
F + + YI + H + K++ +T+LR I A H R L ++ P PL
Sbjct: 399 FLLAFEHYINYRKHHVTH--FWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFL 456
Query: 390 ELF 392
E+F
Sbjct: 457 EVF 459
>gi|117938742 constitutive androstane receptor isoform 15 [Homo
sapiens]
Length = 267
Score = 165 bits (417), Expect = 8e-41
Identities = 102/285 (35%), Positives = 147/285 (51%), Gaps = 53/285 (18%)
Query: 66 RRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALI 125
RR + ++ CPF G+CE+++ RR C ACRL+KCL++GM+K+MI+S EA+ RRA
Sbjct: 7 RRTVSKSIGPTCPFA-GSCEVSKTQRRHCPACRLQKCLDAGMRKDMILSAEALALRRAKQ 65
Query: 126 KRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRVSLQLRGEDGSV 185
++++++T Q L++EQ +IR L+ A + T F F FR L +
Sbjct: 66 AQRRAQQTPVQ------LSKEQEELIRTLLGAHTRHMGTMFEQFVQFRPPAHLFIHHQPL 119
Query: 186 WNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFE 245
P + L+ H AD++T+M +I F K + FR LPIEDQISLLKGAA E
Sbjct: 120 PTLAP--------VLPLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVE 171
Query: 246 LCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVL 305
+C + NT F +T + CG L Y +ED A
Sbjct: 172 ICHIVLNTTFCLQTQNFLCGPLRYTIEDGA------------------------------ 201
Query: 306 MQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHR 350
DRPGV Q +DQLQE+ A+TL+SYI+ + +P R
Sbjct: 202 --------RDRPGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDR 238
>gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens]
Length = 448
Score = 159 bits (401), Expect = 5e-39
Identities = 123/392 (31%), Positives = 183/392 (46%), Gaps = 39/392 (9%)
Query: 9 WNHADFVHCEDTES------VPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEGCK 62
W H +T+S VP PS V P C VC DK++GYH+ V CEGCK
Sbjct: 45 WQHRHTAQSIETQSTSSEELVPSPPSPLPPPRVYKP--CFVCQDKSSGYHYGVSACEGCK 102
Query: 63 GFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERR 122
GFFRR++++N C R C I + TR +CQ CRL+KC E GM KE + +D
Sbjct: 103 GFFRRSIQKNMIYTC-HRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDR------ 155
Query: 123 ALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRVSLQLRGED 182
+KK E + + +T E + ++ A +TF + K
Sbjct: 156 ---NKKKKETSKQECTESYEMTAELDDLTEKIRKAHQETFPSLCQLGK------------ 200
Query: 183 GSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGA 242
+ AD + L ++++T I+ FAK + F L I DQI+LLK A
Sbjct: 201 ---YTTNSSADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAA 257
Query: 243 AFELCQLRFNTVFNAE--TGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHE 300
++ LR T + E T T+ G + GF L + + F L L++ +
Sbjct: 258 CLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGP-LTDLVFTFANQLLPLEMDD 316
Query: 301 EEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAML 360
E L+ AI L DR + + VD+LQE LK YI RP H +F KI+ +
Sbjct: 317 TETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPH--MFPKILMKI 374
Query: 361 TELRSINAQHTQRLLRIQ-DIHPFATPLMQEL 391
T+LRSI+A+ +R++ ++ +I PL+QE+
Sbjct: 375 TDLRSISAKGAERVITLKMEIPGSMPPLIQEM 406
>gi|40806160 thyroid hormone receptor, alpha isoform 1 [Homo
sapiens]
Length = 410
Score = 156 bits (394), Expect = 4e-38
Identities = 111/363 (30%), Positives = 174/363 (47%), Gaps = 21/363 (5%)
Query: 41 CRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNAR--LRCPFRKGACEITRKTRRQCQACR 98
C VCGDKATGYH+ +TCEGCKGFFRR +++N C + C I + TR QCQ CR
Sbjct: 53 CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKY-DSCCVIDKITRNQCQLCR 111
Query: 99 LRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGL------TEEQRMMIR 152
+KC+ GM ++++ D +R LI++ + R + ++ L T E+ +I
Sbjct: 112 FKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEM--IRSLQQRPEPTPEEWDLIH 169
Query: 153 ELMDAQMKTFDTTFSHFKNFRVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTY 212
+A T + SH+K R L + + P D E FS + T
Sbjct: 170 IATEAHRST-NAQGSHWKQRRKFLPDDIGQSPIVS-MPDGDKVDLEAFS---EFTKIITP 224
Query: 213 MFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWE-CGRLSYCL 271
++ FAK + F +LP EDQI LLKG E+ LR ++ E+ T G ++
Sbjct: 225 AITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKR 284
Query: 272 EDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQ 331
E G ++ + + + L L + E L+QA+ L S DR G+L +++ QE
Sbjct: 285 EQLKNGGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEA 344
Query: 332 FAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHP--FATPLMQ 389
+ + + Y+ + H + K++ +T+LR I A H R L ++ P PL
Sbjct: 345 YLLAFEHYVNHRKHNIPH--FWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFL 402
Query: 390 ELF 392
E+F
Sbjct: 403 EVF 405
>gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens]
Length = 457
Score = 155 bits (392), Expect = 6e-38
Identities = 124/392 (31%), Positives = 189/392 (48%), Gaps = 41/392 (10%)
Query: 9 WNHADFVHCEDTES------VPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEGCK 62
WN ++ H +T+S VP PS + P C VC DK++GYH+ V CEGCK
Sbjct: 49 WNGSN--HSIETQSSSSEEIVPSPPSPPPLPRIYKP--CFVCQDKSSGYHYGVSACEGCK 104
Query: 63 GFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERR 122
GFFRR++++N C R C I + TR +CQ CRL+KC E GM KE + +D +++
Sbjct: 105 GFFRRSIQKNMVYTC-HRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDR--NKKK 161
Query: 123 ALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRVSLQLRGED 182
+ + + + T V L E+ R +E A + T ++ RVSL D
Sbjct: 162 KEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSL-----D 216
Query: 183 GSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGA 242
+W+ +++ST + FAK + F L I DQI+LLK A
Sbjct: 217 IDLWD-----------------KFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAA 259
Query: 243 AFELCQLRFNTVFNAE--TGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHE 300
++ LR T + E T T+ G + GF L + + F L L++ +
Sbjct: 260 CLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGP-LTDLVFAFANQLLPLEMDD 318
Query: 301 EEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAML 360
E L+ AI L DR + Q VD LQE LK Y+ RP H +F K++ +
Sbjct: 319 AETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPH--MFPKMLMKI 376
Query: 361 TELRSINAQHTQRLLRIQ-DIHPFATPLMQEL 391
T+LRSI+A+ +R++ ++ +I PL+QE+
Sbjct: 377 TDLRSISAKGAERVITLKMEIPGSMPPLIQEM 408
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.137 0.418
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,468,233
Number of Sequences: 37866
Number of extensions: 676639
Number of successful extensions: 2636
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 119
Number of HSP's successfully gapped in prelim test: 9
Number of HSP's that attempted gapping in prelim test: 2173
Number of HSP's gapped (non-prelim): 208
length of query: 397
length of database: 18,247,518
effective HSP length: 104
effective length of query: 293
effective length of database: 14,309,454
effective search space: 4192670022
effective search space used: 4192670022
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.