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Search of human proteins with 146229340
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|146229340 mutated in colorectal cancers isoform 1 [Homo
sapiens]
(1019 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|146229340 mutated in colorectal cancers isoform 1 [Homo sapiens] 1956 0.0
gi|4505129 mutated in colorectal cancers isoform 2 [Homo sapiens] 1550 0.0
gi|31543140 Usher syndrome 1C binding protein 1 [Homo sapiens] 161 3e-39
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 93 1e-18
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 90 9e-18
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 90 1e-17
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 90 1e-17
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 90 1e-17
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 90 1e-17
gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens] 87 8e-17
gi|55770834 centromere protein F [Homo sapiens] 86 2e-16
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 84 5e-16
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 84 9e-16
gi|21735548 centrosomal protein 2 [Homo sapiens] 83 2e-15
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 82 3e-15
gi|156104908 myosin heavy chain 6 [Homo sapiens] 82 3e-15
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 81 6e-15
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 81 6e-15
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 81 6e-15
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 81 6e-15
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 80 1e-14
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 80 1e-14
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 80 1e-14
gi|31982906 cingulin-like 1 [Homo sapiens] 79 2e-14
gi|33946313 ninein isoform 4 [Homo sapiens] 79 3e-14
gi|33946321 ninein isoform 5 [Homo sapiens] 79 3e-14
gi|148536871 ninein isoform 1 [Homo sapiens] 79 3e-14
gi|148536869 ninein isoform 2 [Homo sapiens] 79 3e-14
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 77 8e-14
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 77 8e-14
>gi|146229340 mutated in colorectal cancers isoform 1 [Homo sapiens]
Length = 1019
Score = 1956 bits (5068), Expect = 0.0
Identities = 1019/1019 (100%), Positives = 1019/1019 (100%)
Query: 1 MMAAAAAAAAGSSSSGGGGGGSGSSSSSSDTSSTGEEERMRRLFQTCDGDGDGYISRNDL 60
MMAAAAAAAAGSSSSGGGGGGSGSSSSSSDTSSTGEEERMRRLFQTCDGDGDGYISRNDL
Sbjct: 1 MMAAAAAAAAGSSSSGGGGGGSGSSSSSSDTSSTGEEERMRRLFQTCDGDGDGYISRNDL 60
Query: 61 LMVCRQLNMEESVAEIMNQLGADENGKISFQDFTRCRMQLVREIRKEEVDLSAKSDNSCT 120
LMVCRQLNMEESVAEIMNQLGADENGKISFQDFTRCRMQLVREIRKEEVDLSAKSDNSCT
Sbjct: 61 LMVCRQLNMEESVAEIMNQLGADENGKISFQDFTRCRMQLVREIRKEEVDLSAKSDNSCT 120
Query: 121 KKLRDRIASWPTSSDNSLGALSAARESWEYDSGARDLQSPDVQSQSALQKLLEYGGSSLH 180
KKLRDRIASWPTSSDNSLGALSAARESWEYDSGARDLQSPDVQSQSALQKLLEYGGSSLH
Sbjct: 121 KKLRDRIASWPTSSDNSLGALSAARESWEYDSGARDLQSPDVQSQSALQKLLEYGGSSLH 180
Query: 181 QQAALHKLLTQSPHIGNSVGGSYLELANTLHSAALASLKGDIVELNKRLQQTERERDLLE 240
QQAALHKLLTQSPHIGNSVGGSYLELANTLHSAALASLKGDIVELNKRLQQTERERDLLE
Sbjct: 181 QQAALHKLLTQSPHIGNSVGGSYLELANTLHSAALASLKGDIVELNKRLQQTERERDLLE 240
Query: 241 KKLAKAQCEQSHLMREHEDVQERTTLRYEERITELHSVIAELNKKIDRLQGTTIREEDEY 300
KKLAKAQCEQSHLMREHEDVQERTTLRYEERITELHSVIAELNKKIDRLQGTTIREEDEY
Sbjct: 241 KKLAKAQCEQSHLMREHEDVQERTTLRYEERITELHSVIAELNKKIDRLQGTTIREEDEY 300
Query: 301 SELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLE 360
SELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLE
Sbjct: 301 SELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLE 360
Query: 361 NVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPNLAEERSR 420
NVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPNLAEERSR
Sbjct: 361 NVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPNLAEERSR 420
Query: 421 WEKELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQAT 480
WEKELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQAT
Sbjct: 421 WEKELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQAT 480
Query: 481 GPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSE 540
GPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSE
Sbjct: 481 GPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSE 540
Query: 541 ISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVETERLNSRIEHL 600
ISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVETERLNSRIEHL
Sbjct: 541 ISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVETERLNSRIEHL 600
Query: 601 KSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYELLLALAESEQ 660
KSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYELLLALAESEQ
Sbjct: 601 KSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYELLLALAESEQ 660
Query: 661 SLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAV 720
SLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAV
Sbjct: 661 SLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAV 720
Query: 721 AGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLEL 780
AGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLEL
Sbjct: 721 AGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLEL 780
Query: 781 ESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKALELKL 840
ESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKALELKL
Sbjct: 781 ESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKALELKL 840
Query: 841 STREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKECADAASPALSLAEL 900
STREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKECADAASPALSLAEL
Sbjct: 841 STREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKECADAASPALSLAEL 900
Query: 901 RTTCSENELAAEFTNAIRREKKLKARVQELVSALERLTKSSEIRHQQSAEFVNDLKRANS 960
RTTCSENELAAEFTNAIRREKKLKARVQELVSALERLTKSSEIRHQQSAEFVNDLKRANS
Sbjct: 901 RTTCSENELAAEFTNAIRREKKLKARVQELVSALERLTKSSEIRHQQSAEFVNDLKRANS 960
Query: 961 NLVAAYEKAKKKHQNKLKKLESQMMAMVERHETQVRMLKQRIALLEEENSRPHTNETSL 1019
NLVAAYEKAKKKHQNKLKKLESQMMAMVERHETQVRMLKQRIALLEEENSRPHTNETSL
Sbjct: 961 NLVAAYEKAKKKHQNKLKKLESQMMAMVERHETQVRMLKQRIALLEEENSRPHTNETSL 1019
>gi|4505129 mutated in colorectal cancers isoform 2 [Homo sapiens]
Length = 829
Score = 1550 bits (4012), Expect = 0.0
Identities = 810/810 (100%), Positives = 810/810 (100%)
Query: 210 LHSAALASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYE 269
LHSAALASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYE
Sbjct: 20 LHSAALASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYE 79
Query: 270 ERITELHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVS 329
ERITELHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVS
Sbjct: 80 ERITELHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVS 139
Query: 330 IPENQSTMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTAS 389
IPENQSTMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTAS
Sbjct: 140 IPENQSTMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTAS 199
Query: 390 EHCDLAIKTVEEIEGVLGRDLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRT 449
EHCDLAIKTVEEIEGVLGRDLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRT
Sbjct: 200 EHCDLAIKTVEEIEGVLGRDLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRT 259
Query: 450 KATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSN 509
KATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSN
Sbjct: 260 KATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSN 319
Query: 510 DIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQ 569
DIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQ
Sbjct: 320 DIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQ 379
Query: 570 TLYSHGSAISESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKYE 629
TLYSHGSAISESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKYE
Sbjct: 380 TLYSHGSAISESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKYE 439
Query: 630 SNATALRLALQYSEQCIEAYELLLALAESEQSLILGQFRAAGVGSSPGDQSGDENITQML 689
SNATALRLALQYSEQCIEAYELLLALAESEQSLILGQFRAAGVGSSPGDQSGDENITQML
Sbjct: 440 SNATALRLALQYSEQCIEAYELLLALAESEQSLILGQFRAAGVGSSPGDQSGDENITQML 499
Query: 690 KRAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDT 749
KRAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDT
Sbjct: 500 KRAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDT 559
Query: 750 EFTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLM 809
EFTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLM
Sbjct: 560 EFTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLM 619
Query: 810 QELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRM 869
QELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRM
Sbjct: 620 QELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRM 679
Query: 870 RSLSSTSSGSKDKPGKECADAASPALSLAELRTTCSENELAAEFTNAIRREKKLKARVQE 929
RSLSSTSSGSKDKPGKECADAASPALSLAELRTTCSENELAAEFTNAIRREKKLKARVQE
Sbjct: 680 RSLSSTSSGSKDKPGKECADAASPALSLAELRTTCSENELAAEFTNAIRREKKLKARVQE 739
Query: 930 LVSALERLTKSSEIRHQQSAEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMMAMVE 989
LVSALERLTKSSEIRHQQSAEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMMAMVE
Sbjct: 740 LVSALERLTKSSEIRHQQSAEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMMAMVE 799
Query: 990 RHETQVRMLKQRIALLEEENSRPHTNETSL 1019
RHETQVRMLKQRIALLEEENSRPHTNETSL
Sbjct: 800 RHETQVRMLKQRIALLEEENSRPHTNETSL 829
Score = 35.8 bits (81), Expect = 0.21
Identities = 24/108 (22%), Positives = 50/108 (46%)
Query: 204 LELANTLHSAALASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQER 263
L+L N + L ++K ++ EL +L E+E+ LE KL+ + ++ + E ++
Sbjct: 611 LDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSE 670
Query: 264 TTLRYEERITELHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQ 311
+ E+R+ L S + K + +ELR+ S+++
Sbjct: 671 VEEQKEQRMRSLSSTSSGSKDKPGKECADAASPALSLAELRTTCSENE 718
>gi|31543140 Usher syndrome 1C binding protein 1 [Homo sapiens]
Length = 703
Score = 161 bits (407), Expect = 3e-39
Identities = 161/595 (27%), Positives = 261/595 (43%), Gaps = 101/595 (16%)
Query: 422 EKELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATG 481
++E A L E N L L S+E+EL RT+A++ AIR E++ L++ V+ELQ L ++
Sbjct: 170 QREAARLAERNAWLRLALSSREDELVRTQASLEAIRAEKETLQKEVQELQDSLLRLE--- 226
Query: 482 PSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEI 541
P S N+ +G S SS +DR ++
Sbjct: 227 ---PCPHLSHNQAGGSGSG--------------------------SSSSEADREPWETQD 257
Query: 542 SSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVETERLNSRIEHLK 601
S S+A L L+ S+ Q L S + ++ E + E+L IE LK
Sbjct: 258 SF-----SLAHPLLRRLRSHSSTQ----ILGSLPNQPLSPEMHIMEAQMEQLRGSIEKLK 308
Query: 602 SQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYELLLALAESEQS 661
N LL+ L+ K E +SM +G+ E+ ATAL LALQYSE C EAY +LLAL E++
Sbjct: 309 CFNRLLSAVLQGYKGRCEGLSMQLGQREAEATALHLALQYSEHCEEAYRVLLALREAD-- 366
Query: 662 LILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAVA 721
S GD++ ++ + AE A LL + + + A
Sbjct: 367 ------------SGAGDEAPMSDL-----------QAAEKEAWRLLAQEEAAMD-----A 398
Query: 722 GCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLELE 781
G P S SS D +E +L+ Y+Q+L+ R+ +K+ L
Sbjct: 399 GAQQNP-----------QPSPEGSSVDKPTPQEVAFQLRSYVQRLQERRSLMKI--LSEP 445
Query: 782 SIHIDPLSYDVKPRGDSQRL----------DLENAVLMQELMAMKEEMAELKAQLYLLEK 831
+ P+ + Q + LE + Q+L+A +E +A+L +L L+ +
Sbjct: 446 GPTLAPMPTVPRAEAMVQAILGTQAGPALPRLEKTQIQQDLVAAREALADLMLRLQLVRR 505
Query: 832 EKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKE----- 886
EK+ LEL+ + A A+++ +E L+ E E + S SSG +E
Sbjct: 506 EKRGLELREAALRALGPAHVLLLEQLRWERAELQAGGANSSGGHSSGGGSSGDEEEWYQG 565
Query: 887 --CADAASPALSLAELRTTCSENELAAEFTNAIRREKKLKARVQELVSALERLTKSSEIR 944
+ + ++ +LA E ++ R L+ ++Q L LE++ + R
Sbjct: 566 LPAVPGGTSGIDGGQVGRAWDPEKLAQELAASLTRTLDLQEQLQSLRRELEQVAQKGRAR 625
Query: 945 HQQSAEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMMAMVERHETQVRMLK 999
QSAE DL +A+S LV A+ A +K + + +KLE QM M + +V +L+
Sbjct: 626 RSQSAELNRDLCKAHSALVLAFRGAHRKQEEQRRKLEQQMALMEAQQAEEVAVLE 680
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 92.8 bits (229), Expect = 1e-18
Identities = 174/885 (19%), Positives = 339/885 (38%), Gaps = 113/885 (12%)
Query: 212 SAALASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHL-MREHEDVQERTTLRYE- 269
S L L+ + ++L +L E ERD+ KK+ + E L M + + + E L +E
Sbjct: 374 SDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWEL 433
Query: 270 ---ERITEL---------HSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNED 317
R +EL H V + ++ +L+ ELR+ + + ++
Sbjct: 434 EQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKI 493
Query: 318 SRSMDQDQT---SVSIPENQSTMVTADMDNCSDLNSELQRVLTGLENVV-CGRKKSSCSL 373
+ ++Q V I EN+ + NC +L+ +L + LE + R+ S +
Sbjct: 494 LKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQI 553
Query: 374 SVAEVDR-HIEQLTTASEH-----CDLAIKTVEEIEGVLGRDL----------------- 410
+ E + H+ Q ++ + +K +E+ +L +
Sbjct: 554 KILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQI 613
Query: 411 ------YPNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLR 464
Y E E EL L +ENE +L K L T + A+ +E L
Sbjct: 614 KKELEHYKEKGERAEELENELHHLEKENE----LLQKKITNLKITCEKIEALEQENSELE 669
Query: 465 RRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSK 524
R R+L+ L S + L N ++ EL + S K+A+ +
Sbjct: 670 RENRKLKKTLDSFKNLTFQLES-LEKENSQLDEENLELRRNVESLKCASMKMAQL----Q 724
Query: 525 TRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQ--DCSNIQEIFQTLYSHGSAIS--E 580
++ S++ L + + S E L S Q D N Q + +TL + I E
Sbjct: 725 LENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIEN-QRLQKTLENSNKKIQQLE 783
Query: 581 SKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERMSMLVG---KYESNATALRL 637
S++++ E+E + L +E LK + L +E KS + S L + E LR
Sbjct: 784 SELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQ 843
Query: 638 ALQYSEQCIEAYELLLALAESEQSLI---LGQFRAAGVGSSPGDQSGDENI--------- 685
+ + +E + + E E + +G ++ + V ++ E +
Sbjct: 844 QAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKT 903
Query: 686 --------------TQML-----KRAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQ 726
TQ + K H+ K N + LL + + + ++
Sbjct: 904 LVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKER-LLHDEQSTDDSRYKLLESKLE 962
Query: 727 PWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIHID 786
+L + A E + Q+L+ ++ +K + A+K E +
Sbjct: 963 --STLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSS 1020
Query: 787 PLSYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQ 846
P G+ + + E+ +EL+ +K+ + E++ L+ EK+AL+ +L E Q
Sbjct: 1021 P-----PISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQ 1075
Query: 847 EQAYLVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKECADAASPALSLAELRTTCSE 906
I L+ + +EQ + + + +K + ++ S +L + +
Sbjct: 1076 NNNLQAQILALQRQTVSLQEQ---NTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQ 1132
Query: 907 NELAAEFTNAIRREKKLKARVQELVSALERLTKSSEIRHQQSAEFVNDLKRANSNLVAAY 966
+ L E + I+ + LK+ L+ E+L E+ H++ A L + L +A+
Sbjct: 1133 SSLENENESVIKEREDLKSLYDSLIKDHEKL----ELLHERQASEYESLISKHGTLKSAH 1188
Query: 967 EKAKKKHQNKLKKLESQMMAMVERHETQVRMLK--QRIALLEEEN 1009
+ + +H++ L+ +Q++ + E +MLK Q LLE +N
Sbjct: 1189 KNLEVEHRD-LEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKN 1232
Score = 38.9 bits (89), Expect = 0.025
Identities = 56/256 (21%), Positives = 109/256 (42%), Gaps = 18/256 (7%)
Query: 772 AVKLTMLELESIHIDPLSYDVK-PRGDSQRLDLENAVLMQELMAMKEEMAELKAQ---LY 827
AV++ LE E +D++ + + L +N VL++ +++++ +A+ L+
Sbjct: 319 AVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLH 378
Query: 828 LLEKEKKALELKLSTREAQEQAYLVHIEHLKSE----VEEQKEQRMRSLSSTSSGSKDKP 883
LEKE L+ KL E + IE L E QK+ SL +
Sbjct: 379 ELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISR 438
Query: 884 GKECADAASPALSLAELRTTCSENELAAEFTNAIRREKKLKARVQELVSALERL--TKSS 941
E ++A +L E+ S L E N + L V+EL + ++ + S
Sbjct: 439 TSELSEAPQKSLG-HEVNELTSSRLLKLEMEN-----QSLTKTVEELRTTVDSVEGNASK 492
Query: 942 EIRHQQSAEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMMAMVERHETQVRMLKQR 1001
++ ++ + ++ N + +++ + QN K L + + + ET +++
Sbjct: 493 ILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQ 552
Query: 1002 IALLEEENSRPHTNET 1017
I +LE+EN H N+T
Sbjct: 553 IKILEQENE--HLNQT 566
Score = 32.7 bits (73), Expect = 1.8
Identities = 36/134 (26%), Positives = 64/134 (47%), Gaps = 9/134 (6%)
Query: 483 SSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSES-SSSDRPVLGSEI 541
SS G +RP + +G STS+S+N+ + ++ +++R +S SS + +L
Sbjct: 1546 SSTGSRVHASRPASLDSGRTSTSNSNNNASLHEVKAGAVNNQSRPQSHSSGEFSLLHDHE 1605
Query: 542 SSIGVSSSVAEHLAHSLQDCSNIQ-EIFQTLYSH------GSAISE-SKIREFEVETERL 593
+ SS ++L + +Q +I +TL S GS SE +++F E+ +L
Sbjct: 1606 AWSSSGSSPIQYLKRQTRSSPVLQHKISETLESRHHKIKTGSPGSEVVTLQQFLEESNKL 1665
Query: 594 NSRIEHLKSQNDLL 607
S SQ +LL
Sbjct: 1666 TSVQIKSSSQENLL 1679
Score = 30.8 bits (68), Expect = 6.8
Identities = 53/293 (18%), Positives = 116/293 (39%), Gaps = 31/293 (10%)
Query: 740 TSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQ 799
+SS S C + K E R + +L + +A ++ ELE + + + + +
Sbjct: 228 SSSAQSPCGSPGMKRTESR-QHLSVELADAKAKIRRLRQELE----EKTEQLLDCKQELE 282
Query: 800 RLDLENAVLMQELMAMKEEMAELKAQLYLLE----KEKKALELKLSTREAQEQAYLVHIE 855
++++E L QE M + + A++Y E +EK KL + ++ + L IE
Sbjct: 283 QMEIELKRLQQENMNLLSDARS--ARMYRDELDALREKAVRVDKLESEVSRYKERLHDIE 340
Query: 856 HLKSEVEEQKEQRMRSLSSTSSGSKDKPGKECADAASPALSLAELRTTCSENELAAEFTN 915
K+ VEE KE L + + G L L+ +++ E
Sbjct: 341 FYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDM 400
Query: 916 AIRREKKLKARVQELVSA--------------LERLTKSSEIRHQQSAEFVNDLKRANSN 961
++ ++L L A LE+++++SE+ +++ S+
Sbjct: 401 DRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSS 460
Query: 962 LVAAYEKAKKKHQNKLKKLESQM------MAMVERHETQVRMLKQRIALLEEE 1008
+ E + +++L + + + + + E + + L +++ +LE E
Sbjct: 461 RLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENE 513
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 90.1 bits (222), Expect = 9e-18
Identities = 167/883 (18%), Positives = 347/883 (39%), Gaps = 111/883 (12%)
Query: 203 YLELANTLHSAA----LASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHE 258
Y ++ L SA +AS+K + L + L+++E R LE+K+ E++ L + +
Sbjct: 833 YFKIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQ 892
Query: 259 DVQERTTLRYEERITELHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDS 318
Q+ EER +L +L K+ + EE+ +EL ++ + + E +E
Sbjct: 893 AEQDNLA-DAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELK 951
Query: 319 RSMDQDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEV 378
R +D + +++ E + + N L + GL+ ++ K +L A
Sbjct: 952 RDIDDLELTLAKVEKEKHATENKVKN-------LTEEMAGLDEIIAKLTKEKKALQEAH- 1003
Query: 379 DRHIEQLTTASEHCDLAIKT-------VEEIEGVLGRDLYPNLAEERSRWEKE------- 424
+ ++ L + + K V+++EG L ++ + ER++ + E
Sbjct: 1004 QQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQ 1063
Query: 425 --LAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSV----- 477
+ L + + L L K+ ELN A + + +L+++++ELQ R++ +
Sbjct: 1064 ESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELE 1123
Query: 478 -QATGPSSPGRLTS-TNRPINPSTGELSTSSSSNDIPIAKIAER-VKLSKTRSESSSSDR 534
+ T + +L S +R + + L + + + I +R + K R + +
Sbjct: 1124 AERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRD---LEE 1180
Query: 535 PVLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVETERLN 594
L E ++ + A+ +A + N+Q + Q L E + EF++E + +
Sbjct: 1181 ATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKL--------EKEKSEFKLELDDVT 1232
Query: 595 SRIEHL---KSQNDLLTITLE----ECKSNAERMSMLVGKYESNATALRLALQYSEQCIE 647
S +E + K+ + + TLE E +S AE V S L+ + ++
Sbjct: 1233 SNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLD 1292
Query: 648 AYELLLALAESEQSLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDC-----RKTAENA 702
E L++ + Q ++ + + HDC + E
Sbjct: 1293 EKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETE 1352
Query: 703 AKALLMKLDGSCGGAFAVAGCSVQPW-------------------ESLSSNSHTSTTSST 743
AKA L ++ + A V W + L+ + +
Sbjct: 1353 AKAELQRV-------LSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVE 1405
Query: 744 ASSCDTEFTKEDEQRLKDYIQQLKND--RAAVKLTMLELESIHIDPLSYDVKPRGDSQRL 801
A + ++ + RL++ I+ L D R+ L+ + + D + + K + + +
Sbjct: 1406 AVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQS 1465
Query: 802 DLENA-----VLMQELMAMKEEMAELKAQLYLLEKEKKALELKLS--TREAQEQAYLVH- 853
+LE++ L EL +K E L ++E K L+ ++S T + +H
Sbjct: 1466 ELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHE 1525
Query: 854 IEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKECADAASPALSLAELRTTCSENELAAEF 913
+E ++ ++E +K + +L + + + GK AE+ +E + E
Sbjct: 1526 LEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKD--EEM 1583
Query: 914 TNAIRREKKLKARVQELVSALERLTKSSEIRHQQSAEFVNDLKRAN------SNLVAAYE 967
A R ++ V L ++L+ T+S + + DL + + A +
Sbjct: 1584 EQAKRNHLRV---VDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQ 1640
Query: 968 KAKKKHQNKLKKLESQMMAMVERHETQVRMLKQRIALLEEENS 1010
K K Q+ LK + Q+ V ++ LK+ IA++E N+
Sbjct: 1641 KQVKSLQSLLKDTQIQLDDAVRANDD----LKENIAIVERRNN 1679
Score = 61.2 bits (147), Expect = 5e-09
Identities = 159/841 (18%), Positives = 327/841 (38%), Gaps = 128/841 (15%)
Query: 71 ESVAEIMNQLGADENGKISFQDFTRCRMQLVREIRKEEVDLSAKSDNSCTKKLRDRIASW 130
E ++E + + G + +I Q +R +E + + KK D +A
Sbjct: 1144 EEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAEL 1203
Query: 131 PTSSDNSLGALSAARESWEYDSGARDLQSPDVQS--------QSALQKLL--------EY 174
DN L ++ E + L+ DV S ++ L+K+ E+
Sbjct: 1204 GEQIDN----LQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEH 1259
Query: 175 GGSSLHQQAALHKLLTQSPHIGNSVGGSYLELANTLHS--AALASLKGDIVELNKRLQQT 232
+ Q +++ L +Q + G EL+ L A ++ L + ++L+
Sbjct: 1260 RSKAEETQRSVNDLTSQRAKLQTENG----ELSRQLDEKEALISQLTRGKLTYTQQLEDL 1315
Query: 233 ERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERI---TELHSVIAELNKKI--- 286
+R+ LE+++ KA+ +H ++ + +YEE EL V+++ N ++
Sbjct: 1316 KRQ---LEEEV-KAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQW 1371
Query: 287 -DRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTADMDNC 345
+ + I+ +E E + +L+Q E E V A C
Sbjct: 1372 RTKYETDAIQRTEELEEAKKKLAQRLQEAEE--------------------AVEAVNAKC 1411
Query: 346 SDLNSELQRVLTGLENVVCGRKKSSCSLSVAEV-DRHIEQLTTASEHCDLAIKTVEEIEG 404
S L R+ +E+++ ++S+ + + + R+ +++ + ++ E
Sbjct: 1412 SSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQ 1471
Query: 405 VLGRDLYPNLAEERSRWEKELAGL---REENESLTAMLCSKEEELNRTKATMNAIREERD 461
R L L + ++ +E+ L L + EN++L + E+L + T++ + + R
Sbjct: 1472 KEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRK 1531
Query: 462 RLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVK 521
+L ELQ+ L+ +A+ G++ N E+ + D + + A+R
Sbjct: 1532 QLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQ-AKRNH 1590
Query: 522 LSKTRSESSSSD------RPVLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHG 575
L S +S D L + G + + L+H+ + + Q+ ++L
Sbjct: 1591 LRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQ--- 1647
Query: 576 SAISESKIREFEV--ETERLNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKYESNAT 633
S + +++I+ + + L I ++ +N+LL LEE ++ E+
Sbjct: 1648 SLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQ----------TER 1697
Query: 634 ALRLALQYSEQCIEAYELLLALAESEQSLILGQFRAAGVGSSPGDQSGDENITQMLKRAH 693
+ +LA ++ IE E + L SLI + + D + T++ +
Sbjct: 1698 SRKLA---EQELIETSERVQLLHSQNTSLINQKKKM--------DADLSQLQTEVEEAVQ 1746
Query: 694 DCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTK 753
+CR E A KA+ A +A E L TS K
Sbjct: 1747 ECRNAEEKAKKAIT--------DAAMMA-------EELKKEQDTSAHLE-------RMKK 1784
Query: 754 EDEQRLKDYIQQL-KNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLMQEL 812
EQ +KD +L + ++ A+K +L+ + + + R L+ E + +
Sbjct: 1785 NMEQTIKDLQHRLDEAEQIALKGGKKQLQKL-------EARVRELENELEAEQKRNAESV 1837
Query: 813 MAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSL 872
M++ +K Y E+++K L L+L + Q + ++ K + EE +EQ +L
Sbjct: 1838 KGMRKSERRIKELTYQTEEDRKNL-LRLQDLVDKLQ---LKVKAYKRQAEEAEEQANTNL 1893
Query: 873 S 873
S
Sbjct: 1894 S 1894
Score = 42.4 bits (98), Expect = 0.002
Identities = 53/231 (22%), Positives = 108/231 (46%), Gaps = 29/231 (12%)
Query: 788 LSYDVKPRGDSQRLDLENAVLMQELMAMKEEM-------AELKAQLYLLEKEKKALELKL 840
L + +KP S + E A + +E +KE + EL+ ++ L +EK L+L++
Sbjct: 832 LYFKIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQV 891
Query: 841 STR-----EAQEQA--YLVHIEHLKSEVEEQKE--QRMRSLSSTSSGSKDKPGKECADAA 891
+A+E+ + + L+++V+E E + +++ + K K EC++
Sbjct: 892 QAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELK 951
Query: 892 SPALSLAELRTTCSENELAAEFT-NAIRREKKLKARVQELVSALERLTKSSEIRHQQSAE 950
+ +L T ++ E T N ++ + A + E+++ L + K+ + HQQ+
Sbjct: 952 R---DIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQA-- 1006
Query: 951 FVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMMAMVERHETQVRMLKQR 1001
++DL +A + V KAK K + ++ LE + E +VRM +R
Sbjct: 1007 -LDDL-QAEEDKVNTLTKAKVKLEQQVDDLEGSL-----EQEKKVRMDLER 1050
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 89.7 bits (221), Expect = 1e-17
Identities = 185/1029 (17%), Positives = 395/1029 (38%), Gaps = 123/1029 (11%)
Query: 60 LLMVCRQLN-MEESVAEIMNQLGADENGKISFQDFTRCRMQLVREIRKEEVDLSAKSDNS 118
LL V RQ M+ E+ + + ++ + QL E + L A+++
Sbjct: 844 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 903
Query: 119 C-TKKLRDRIASWPTSSDNSLGALSAARESWEYDSGARDLQSPDVQSQSALQKLLEYGGS 177
+++R R+A+ + L + A E E D G Q + + Q++L+
Sbjct: 904 AEAEEMRVRLAAKKQELEEILHEMEARLEE-EEDRG----QQLQAERKKMAQQMLDLEEQ 958
Query: 178 SLHQQAALHKLLTQSPHIGNSVGGSYLELANTLHSAALASLKGDIVELNKRLQQTERERD 237
++AA KL +L A + L+ +I+ ++ + + +ER
Sbjct: 959 LEEEEAARQKL----------------QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK 1002
Query: 238 LLEKKLAKAQCEQSHLMREHEDVQERTTL--RYEERITELHSVIAELNKKIDRLQGTTIR 295
LLE++++ ++L E E + T L ++E I+EL + + K L+ +
Sbjct: 1003 LLEERISDL---TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK 1059
Query: 296 EEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTADMDNCSDLNSELQRV 355
E + S+ +++ Q ++ E + + + + + A +N EL+
Sbjct: 1060 LEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGH 1119
Query: 356 LTGLENVVCGRK--KSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRD---L 410
++ L+ + + ++ ++ +E L T E + T +E+ ++ L
Sbjct: 1120 ISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVL 1179
Query: 411 YPNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKATMN---------------- 454
L EE E ++ +R+++ L + E+ R KA ++
Sbjct: 1180 KKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE 1239
Query: 455 --AIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIP 512
+ + + + + ++L+ ++Q +Q+ N ++ E+ + + +
Sbjct: 1240 LRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEA 1299
Query: 513 IAKIAERVKLSKTRSESSSSDRPVLGSEI-SSIGVSSSV--AEHLAHSLQD-CSNIQEIF 568
K + K + S + +L E + VS+ + E +SLQD E
Sbjct: 1300 EGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK 1359
Query: 569 QTLYSHGSAI------SESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERMS 622
Q L H S + S+ K+++F E L + + + + LT EE + +++
Sbjct: 1360 QNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLE 1419
Query: 623 MLVGKYESNATALRLALQYSEQCI-------EAYELLLALAESEQSLILGQFRAAGVGSS 675
+ + L + L Q + ++ LLA E S R +
Sbjct: 1420 KTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA-EEKNISSKYADERDRAEAEA 1478
Query: 676 PGDQSGDENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNS 735
++ ++ + L+ A + ++ E K L +++ V + + N
Sbjct: 1479 REKETKALSLARALEEALEAKEELERTNKMLKAEMED-----------LVSSKDDVGKNV 1527
Query: 736 HTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDVKPR 795
H S A E K + L+D +Q ++ + +++ M L+ D++ R
Sbjct: 1528 HELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG----QFERDLQAR 1583
Query: 796 GDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYL---- 851
+ + + L ++L + E+ + + Q L KK LE L E Q + +
Sbjct: 1584 DEQN--EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGRE 1641
Query: 852 ----------VHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPG--------KECADAASP 893
++ + E+E+ + R ++ K +E AA
Sbjct: 1642 EAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAER 1701
Query: 894 ALSLAELRTTCSENELAAEFT--NAIRREK-KLKARVQELVSALE-----------RLTK 939
A A+L ELA+ + NA++ EK +L+AR+ +L LE R+ K
Sbjct: 1702 ARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRK 1761
Query: 940 SSEIRHQQSAEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMMAMVERHETQVRMLK 999
+++ Q S E + A N +A ++ +++++ KL A+ + ++ + L+
Sbjct: 1762 ATQQAEQLSNELATERSTAQKN-ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALE 1820
Query: 1000 QRIALLEEE 1008
+IA LEE+
Sbjct: 1821 AKIAQLEEQ 1829
Score = 82.0 bits (201), Expect = 3e-15
Identities = 211/1023 (20%), Positives = 396/1023 (38%), Gaps = 147/1023 (14%)
Query: 77 MNQLGADENGKISFQDFTRCRMQLVR-----EIRKEEVDLSAKSD--NSCTKK---LRDR 126
M Q D ++ ++ R ++QL + +I+K E ++ D N +K+ L +R
Sbjct: 948 MAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER 1007
Query: 127 IASWPTS-SDNSLGALSAARESWEYDSGARDLQ---SPDVQSQSALQKL---LEYGGSSL 179
I+ T+ ++ A + + +++S +L+ + +S+ L+KL LE S
Sbjct: 1008 ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1067
Query: 180 HQQAALHKLLTQSPHIGNSVGGSYLELANTLHSAALASLKGDIVELNKRLQQ-------- 231
H+Q A L Q + + EL AALA L +I + N L++
Sbjct: 1068 HEQIA--DLQAQIAELKMQLAKKEEEL-----QAALARLDDEIAQKNNALKKIRELEGHI 1120
Query: 232 TERERDLLEKKLAKAQCEQSH---------LMREHEDVQERTTLRYEERITELHSVIAEL 282
++ + DL ++ A+ + E+ L E ED + T + E R V L
Sbjct: 1121 SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTV-L 1179
Query: 283 NKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTADM 342
K +D T E + E+R + +Q+ E+ E + ++ +N+ T+ +
Sbjct: 1180 KKALDE---ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKR--AKANLDKNKQTLEKENA 1234
Query: 343 DNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTA-SEHCDLAIKTVEE 401
D +L RVL + V KK V E+ A +E D K E
Sbjct: 1235 DLAGEL-----RVLGQAKQEV-EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNE 1288
Query: 402 IEGVLGRDLYPNLAEERS-RWEKELAGLREENESLTAMLCSKEEELNRTKATMNAIREER 460
+E V G N AE ++ + K++A L + + +L + + + + EER
Sbjct: 1289 VESVTGM---LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER 1345
Query: 461 DRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINP--STGE-LSTSSSSNDIPIAKIA 517
+ L+ ++ E Q+++ + +L+ + + + ST E L I +
Sbjct: 1346 NSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLT 1405
Query: 518 ERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSA 577
++ + + + L E+ + V L +L+ Q F L +
Sbjct: 1406 QQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLE---KKQRKFDQLLAEEKN 1462
Query: 578 IS----------ESKIREFEVETERLNSRIEH-------LKSQNDLLTITLEECKSNAER 620
IS E++ RE E + L +E L+ N +L +E+ S+ +
Sbjct: 1463 ISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDD 1522
Query: 621 MSMLVGKYESNATALRLALQYSEQCIEAYELLLALAESEQ-------SLILGQFRAAGVG 673
+ V + E + AL ++ + +E E L E + + GQF
Sbjct: 1523 VGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER---D 1579
Query: 674 SSPGDQSGDENITQMLKRAHDCRKTAENAAK------ALLMKLDGSCGGAFAVAGCSVQP 727
D+ +E Q+ ++ H+ E+ K A KL+G A +++
Sbjct: 1580 LQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKG 1639
Query: 728 WESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYI-QQLKNDRAAVKLTMLELESIHID 786
E A D + ED + +D I K + K +L + D
Sbjct: 1640 REEAIKQLR----KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED 1695
Query: 787 PLSYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQ 846
L+ + R ++ DLE L EE+A + L+ EK+ LE ++
Sbjct: 1696 -LAAAERAR---KQADLEKEELA-------EELASSLSGRNALQDEKRRLEARI------ 1738
Query: 847 EQAYLVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKECADAASPALSLAELRTTCSE 906
+++EE+ E+ ++ + S D+ K A + LA R+T +
Sbjct: 1739 ------------AQLEEELEEEQGNMEAMS----DRVRKATQQAEQLSNELATERSTAQK 1782
Query: 907 NELAAEFTNAIRREKKLKARVQELVSALERLTKSS----EIRHQQSAEFVNDLKRANSNL 962
NE A + R+ K+L++++ E+ A++ KS+ E + Q E V R
Sbjct: 1783 NESARQ--QLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAA 1840
Query: 963 VAAYEKAKKKHQNKL------KKLESQMMAMVERHETQVRMLKQRIALLEEENSRPHTNE 1016
+ ++ KK + L +K+ Q E+ +V+ LK+++ EEE+ R + N
Sbjct: 1841 TKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANR 1900
Query: 1017 TSL 1019
L
Sbjct: 1901 RKL 1903
Score = 64.3 bits (155), Expect = 6e-10
Identities = 134/753 (17%), Positives = 288/753 (38%), Gaps = 64/753 (8%)
Query: 216 ASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITEL 275
A L G++ L + Q+ E ++ LE ++ + Q + S ER +++ +L
Sbjct: 1234 ADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD--------GERARAELNDKVHKL 1285
Query: 276 HSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQS 335
+ + + ++ +G I+ + + L S+L +Q + E++R T + E +
Sbjct: 1286 QNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER 1345
Query: 336 TMVTADMDNCSDLNSELQRVLTGLE-NVVCGRKKSSCSLSVAEV--------DRHIEQLT 386
+ +D + L+R ++ L + +KK S E + IE LT
Sbjct: 1346 NSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLT 1405
Query: 387 TASEHCDLAIKTVEEIEGVLGRDLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEEL 446
E A +E+ + L ++L + + + +++L E+ + L ++E+ +
Sbjct: 1406 QQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN--QRQLVSNLEKKQRKFDQLLAEEKNI 1463
Query: 447 NRTKATMNAIREERDRLRRRVRELQTRLQSVQAT---GPSSPGRLTSTNRPINPSTGELS 503
+ A +ERDR RE +T+ S+ + L TN+ + +L
Sbjct: 1464 SSKYA------DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLV 1517
Query: 504 TSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSN 563
+S + ++ + + +T+ E + L E+ + + L ++Q
Sbjct: 1518 SSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQA---TEDAKLRLEVNMQA--- 1571
Query: 564 IQEIFQTLYSHGSAISESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERM-- 621
++ F+ +E K R+ + + + +E + Q L ++ + + + +
Sbjct: 1572 LKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLEL 1631
Query: 622 ---SMLVGKYESNATALRLALQYSEQCIEAYELLLALAESEQSLILGQFRAAGVGSSPGD 678
S + G+ E+ +L Q + EL A A ++ + S D
Sbjct: 1632 QADSAIKGREEAIKQLRKLQAQMKDF---QRELEDARASRDEIFATAKENEKKAKSLEAD 1688
Query: 679 QSGDENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTS 738
+ + L A RK A+ + L +L S G A+ L +
Sbjct: 1689 LM---QLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQ----DEKRRLEARIAQL 1741
Query: 739 TTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDVKPRGDS 798
+ E + ++ +QL N+ A + T + ES + + R S
Sbjct: 1742 EEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELR--S 1799
Query: 799 QRLDLENAV---LMQELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIE 855
+ ++E AV + A++ ++A+L+ Q+ +EK+A L ++ + + L+ +E
Sbjct: 1800 KLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVE 1859
Query: 856 HLKSEVEEQKEQRMRSLSSTSSGSKDKPGKECADAASPALSLAELRTTCSENELAAEFTN 915
+ E+ KEQ + ++ K K + A R + +L E
Sbjct: 1860 DERKMAEQYKEQ------AEKGNARVKQLKRQLEEAEE----ESQRINANRRKLQRELDE 1909
Query: 916 AIRREKKLKARVQELVSALERLTKSSEIRHQQS 948
A + + V L S L R ++S + ++S
Sbjct: 1910 ATESNEAMGREVNALKSKLRRGNETSFVPSRRS 1942
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 89.7 bits (221), Expect = 1e-17
Identities = 185/1029 (17%), Positives = 395/1029 (38%), Gaps = 123/1029 (11%)
Query: 60 LLMVCRQLN-MEESVAEIMNQLGADENGKISFQDFTRCRMQLVREIRKEEVDLSAKSDNS 118
LL V RQ M+ E+ + + ++ + QL E + L A+++
Sbjct: 851 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 910
Query: 119 C-TKKLRDRIASWPTSSDNSLGALSAARESWEYDSGARDLQSPDVQSQSALQKLLEYGGS 177
+++R R+A+ + L + A E E D G Q + + Q++L+
Sbjct: 911 AEAEEMRVRLAAKKQELEEILHEMEARLEE-EEDRG----QQLQAERKKMAQQMLDLEEQ 965
Query: 178 SLHQQAALHKLLTQSPHIGNSVGGSYLELANTLHSAALASLKGDIVELNKRLQQTERERD 237
++AA KL +L A + L+ +I+ ++ + + +ER
Sbjct: 966 LEEEEAARQKL----------------QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK 1009
Query: 238 LLEKKLAKAQCEQSHLMREHEDVQERTTL--RYEERITELHSVIAELNKKIDRLQGTTIR 295
LLE++++ ++L E E + T L ++E I+EL + + K L+ +
Sbjct: 1010 LLEERISDL---TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK 1066
Query: 296 EEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTADMDNCSDLNSELQRV 355
E + S+ +++ Q ++ E + + + + + A +N EL+
Sbjct: 1067 LEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGH 1126
Query: 356 LTGLENVVCGRK--KSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRD---L 410
++ L+ + + ++ ++ +E L T E + T +E+ ++ L
Sbjct: 1127 ISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVL 1186
Query: 411 YPNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKATMN---------------- 454
L EE E ++ +R+++ L + E+ R KA ++
Sbjct: 1187 KKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE 1246
Query: 455 --AIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIP 512
+ + + + + ++L+ ++Q +Q+ N ++ E+ + + +
Sbjct: 1247 LRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEA 1306
Query: 513 IAKIAERVKLSKTRSESSSSDRPVLGSEI-SSIGVSSSV--AEHLAHSLQD-CSNIQEIF 568
K + K + S + +L E + VS+ + E +SLQD E
Sbjct: 1307 EGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK 1366
Query: 569 QTLYSHGSAI------SESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERMS 622
Q L H S + S+ K+++F E L + + + + LT EE + +++
Sbjct: 1367 QNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLE 1426
Query: 623 MLVGKYESNATALRLALQYSEQCI-------EAYELLLALAESEQSLILGQFRAAGVGSS 675
+ + L + L Q + ++ LLA E S R +
Sbjct: 1427 KTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA-EEKNISSKYADERDRAEAEA 1485
Query: 676 PGDQSGDENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNS 735
++ ++ + L+ A + ++ E K L +++ V + + N
Sbjct: 1486 REKETKALSLARALEEALEAKEELERTNKMLKAEMED-----------LVSSKDDVGKNV 1534
Query: 736 HTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDVKPR 795
H S A E K + L+D +Q ++ + +++ M L+ D++ R
Sbjct: 1535 HELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG----QFERDLQAR 1590
Query: 796 GDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYL---- 851
+ + + L ++L + E+ + + Q L KK LE L E Q + +
Sbjct: 1591 DEQN--EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGRE 1648
Query: 852 ----------VHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPG--------KECADAASP 893
++ + E+E+ + R ++ K +E AA
Sbjct: 1649 EAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAER 1708
Query: 894 ALSLAELRTTCSENELAAEFT--NAIRREK-KLKARVQELVSALE-----------RLTK 939
A A+L ELA+ + NA++ EK +L+AR+ +L LE R+ K
Sbjct: 1709 ARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRK 1768
Query: 940 SSEIRHQQSAEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMMAMVERHETQVRMLK 999
+++ Q S E + A N +A ++ +++++ KL A+ + ++ + L+
Sbjct: 1769 ATQQAEQLSNELATERSTAQKN-ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALE 1827
Query: 1000 QRIALLEEE 1008
+IA LEE+
Sbjct: 1828 AKIAQLEEQ 1836
Score = 82.0 bits (201), Expect = 3e-15
Identities = 211/1023 (20%), Positives = 396/1023 (38%), Gaps = 147/1023 (14%)
Query: 77 MNQLGADENGKISFQDFTRCRMQLVR-----EIRKEEVDLSAKSD--NSCTKK---LRDR 126
M Q D ++ ++ R ++QL + +I+K E ++ D N +K+ L +R
Sbjct: 955 MAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER 1014
Query: 127 IASWPTS-SDNSLGALSAARESWEYDSGARDLQ---SPDVQSQSALQKL---LEYGGSSL 179
I+ T+ ++ A + + +++S +L+ + +S+ L+KL LE S
Sbjct: 1015 ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1074
Query: 180 HQQAALHKLLTQSPHIGNSVGGSYLELANTLHSAALASLKGDIVELNKRLQQ-------- 231
H+Q A L Q + + EL AALA L +I + N L++
Sbjct: 1075 HEQIA--DLQAQIAELKMQLAKKEEEL-----QAALARLDDEIAQKNNALKKIRELEGHI 1127
Query: 232 TERERDLLEKKLAKAQCEQSH---------LMREHEDVQERTTLRYEERITELHSVIAEL 282
++ + DL ++ A+ + E+ L E ED + T + E R V L
Sbjct: 1128 SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTV-L 1186
Query: 283 NKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTADM 342
K +D T E + E+R + +Q+ E+ E + ++ +N+ T+ +
Sbjct: 1187 KKALDE---ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKR--AKANLDKNKQTLEKENA 1241
Query: 343 DNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTA-SEHCDLAIKTVEE 401
D +L RVL + V KK V E+ A +E D K E
Sbjct: 1242 DLAGEL-----RVLGQAKQEV-EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNE 1295
Query: 402 IEGVLGRDLYPNLAEERS-RWEKELAGLREENESLTAMLCSKEEELNRTKATMNAIREER 460
+E V G N AE ++ + K++A L + + +L + + + + EER
Sbjct: 1296 VESVTGM---LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER 1352
Query: 461 DRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINP--STGE-LSTSSSSNDIPIAKIA 517
+ L+ ++ E Q+++ + +L+ + + + ST E L I +
Sbjct: 1353 NSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLT 1412
Query: 518 ERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSA 577
++ + + + L E+ + V L +L+ Q F L +
Sbjct: 1413 QQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLE---KKQRKFDQLLAEEKN 1469
Query: 578 IS----------ESKIREFEVETERLNSRIEH-------LKSQNDLLTITLEECKSNAER 620
IS E++ RE E + L +E L+ N +L +E+ S+ +
Sbjct: 1470 ISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDD 1529
Query: 621 MSMLVGKYESNATALRLALQYSEQCIEAYELLLALAESEQ-------SLILGQFRAAGVG 673
+ V + E + AL ++ + +E E L E + + GQF
Sbjct: 1530 VGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER---D 1586
Query: 674 SSPGDQSGDENITQMLKRAHDCRKTAENAAK------ALLMKLDGSCGGAFAVAGCSVQP 727
D+ +E Q+ ++ H+ E+ K A KL+G A +++
Sbjct: 1587 LQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKG 1646
Query: 728 WESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYI-QQLKNDRAAVKLTMLELESIHID 786
E A D + ED + +D I K + K +L + D
Sbjct: 1647 REEAIKQLR----KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED 1702
Query: 787 PLSYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQ 846
L+ + R ++ DLE L EE+A + L+ EK+ LE ++
Sbjct: 1703 -LAAAERAR---KQADLEKEELA-------EELASSLSGRNALQDEKRRLEARI------ 1745
Query: 847 EQAYLVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKECADAASPALSLAELRTTCSE 906
+++EE+ E+ ++ + S D+ K A + LA R+T +
Sbjct: 1746 ------------AQLEEELEEEQGNMEAMS----DRVRKATQQAEQLSNELATERSTAQK 1789
Query: 907 NELAAEFTNAIRREKKLKARVQELVSALERLTKSS----EIRHQQSAEFVNDLKRANSNL 962
NE A + R+ K+L++++ E+ A++ KS+ E + Q E V R
Sbjct: 1790 NESARQ--QLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAA 1847
Query: 963 VAAYEKAKKKHQNKL------KKLESQMMAMVERHETQVRMLKQRIALLEEENSRPHTNE 1016
+ ++ KK + L +K+ Q E+ +V+ LK+++ EEE+ R + N
Sbjct: 1848 TKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANR 1907
Query: 1017 TSL 1019
L
Sbjct: 1908 RKL 1910
Score = 64.3 bits (155), Expect = 6e-10
Identities = 134/753 (17%), Positives = 288/753 (38%), Gaps = 64/753 (8%)
Query: 216 ASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITEL 275
A L G++ L + Q+ E ++ LE ++ + Q + S ER +++ +L
Sbjct: 1241 ADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD--------GERARAELNDKVHKL 1292
Query: 276 HSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQS 335
+ + + ++ +G I+ + + L S+L +Q + E++R T + E +
Sbjct: 1293 QNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER 1352
Query: 336 TMVTADMDNCSDLNSELQRVLTGLE-NVVCGRKKSSCSLSVAEV--------DRHIEQLT 386
+ +D + L+R ++ L + +KK S E + IE LT
Sbjct: 1353 NSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLT 1412
Query: 387 TASEHCDLAIKTVEEIEGVLGRDLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEEL 446
E A +E+ + L ++L + + + +++L E+ + L ++E+ +
Sbjct: 1413 QQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN--QRQLVSNLEKKQRKFDQLLAEEKNI 1470
Query: 447 NRTKATMNAIREERDRLRRRVRELQTRLQSVQAT---GPSSPGRLTSTNRPINPSTGELS 503
+ A +ERDR RE +T+ S+ + L TN+ + +L
Sbjct: 1471 SSKYA------DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLV 1524
Query: 504 TSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSN 563
+S + ++ + + +T+ E + L E+ + + L ++Q
Sbjct: 1525 SSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQA---TEDAKLRLEVNMQA--- 1578
Query: 564 IQEIFQTLYSHGSAISESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERM-- 621
++ F+ +E K R+ + + + +E + Q L ++ + + + +
Sbjct: 1579 LKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLEL 1638
Query: 622 ---SMLVGKYESNATALRLALQYSEQCIEAYELLLALAESEQSLILGQFRAAGVGSSPGD 678
S + G+ E+ +L Q + EL A A ++ + S D
Sbjct: 1639 QADSAIKGREEAIKQLRKLQAQMKDF---QRELEDARASRDEIFATAKENEKKAKSLEAD 1695
Query: 679 QSGDENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTS 738
+ + L A RK A+ + L +L S G A+ L +
Sbjct: 1696 LM---QLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQ----DEKRRLEARIAQL 1748
Query: 739 TTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDVKPRGDS 798
+ E + ++ +QL N+ A + T + ES + + R S
Sbjct: 1749 EEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELR--S 1806
Query: 799 QRLDLENAV---LMQELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIE 855
+ ++E AV + A++ ++A+L+ Q+ +EK+A L ++ + + L+ +E
Sbjct: 1807 KLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVE 1866
Query: 856 HLKSEVEEQKEQRMRSLSSTSSGSKDKPGKECADAASPALSLAELRTTCSENELAAEFTN 915
+ E+ KEQ + ++ K K + A R + +L E
Sbjct: 1867 DERKMAEQYKEQ------AEKGNARVKQLKRQLEEAEE----ESQRINANRRKLQRELDE 1916
Query: 916 AIRREKKLKARVQELVSALERLTKSSEIRHQQS 948
A + + V L S L R ++S + ++S
Sbjct: 1917 ATESNEAMGREVNALKSKLRRGNETSFVPSRRS 1949
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 89.7 bits (221), Expect = 1e-17
Identities = 185/1029 (17%), Positives = 395/1029 (38%), Gaps = 123/1029 (11%)
Query: 60 LLMVCRQLN-MEESVAEIMNQLGADENGKISFQDFTRCRMQLVREIRKEEVDLSAKSDNS 118
LL V RQ M+ E+ + + ++ + QL E + L A+++
Sbjct: 851 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 910
Query: 119 C-TKKLRDRIASWPTSSDNSLGALSAARESWEYDSGARDLQSPDVQSQSALQKLLEYGGS 177
+++R R+A+ + L + A E E D G Q + + Q++L+
Sbjct: 911 AEAEEMRVRLAAKKQELEEILHEMEARLEE-EEDRG----QQLQAERKKMAQQMLDLEEQ 965
Query: 178 SLHQQAALHKLLTQSPHIGNSVGGSYLELANTLHSAALASLKGDIVELNKRLQQTERERD 237
++AA KL +L A + L+ +I+ ++ + + +ER
Sbjct: 966 LEEEEAARQKL----------------QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK 1009
Query: 238 LLEKKLAKAQCEQSHLMREHEDVQERTTL--RYEERITELHSVIAELNKKIDRLQGTTIR 295
LLE++++ ++L E E + T L ++E I+EL + + K L+ +
Sbjct: 1010 LLEERISDL---TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK 1066
Query: 296 EEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTADMDNCSDLNSELQRV 355
E + S+ +++ Q ++ E + + + + + A +N EL+
Sbjct: 1067 LEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGH 1126
Query: 356 LTGLENVVCGRK--KSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRD---L 410
++ L+ + + ++ ++ +E L T E + T +E+ ++ L
Sbjct: 1127 ISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVL 1186
Query: 411 YPNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKATMN---------------- 454
L EE E ++ +R+++ L + E+ R KA ++
Sbjct: 1187 KKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE 1246
Query: 455 --AIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIP 512
+ + + + + ++L+ ++Q +Q+ N ++ E+ + + +
Sbjct: 1247 LRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEA 1306
Query: 513 IAKIAERVKLSKTRSESSSSDRPVLGSEI-SSIGVSSSV--AEHLAHSLQD-CSNIQEIF 568
K + K + S + +L E + VS+ + E +SLQD E
Sbjct: 1307 EGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK 1366
Query: 569 QTLYSHGSAI------SESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERMS 622
Q L H S + S+ K+++F E L + + + + LT EE + +++
Sbjct: 1367 QNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLE 1426
Query: 623 MLVGKYESNATALRLALQYSEQCI-------EAYELLLALAESEQSLILGQFRAAGVGSS 675
+ + L + L Q + ++ LLA E S R +
Sbjct: 1427 KTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA-EEKNISSKYADERDRAEAEA 1485
Query: 676 PGDQSGDENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNS 735
++ ++ + L+ A + ++ E K L +++ V + + N
Sbjct: 1486 REKETKALSLARALEEALEAKEELERTNKMLKAEMED-----------LVSSKDDVGKNV 1534
Query: 736 HTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDVKPR 795
H S A E K + L+D +Q ++ + +++ M L+ D++ R
Sbjct: 1535 HELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG----QFERDLQAR 1590
Query: 796 GDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYL---- 851
+ + + L ++L + E+ + + Q L KK LE L E Q + +
Sbjct: 1591 DEQN--EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGRE 1648
Query: 852 ----------VHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPG--------KECADAASP 893
++ + E+E+ + R ++ K +E AA
Sbjct: 1649 EAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAER 1708
Query: 894 ALSLAELRTTCSENELAAEFT--NAIRREK-KLKARVQELVSALE-----------RLTK 939
A A+L ELA+ + NA++ EK +L+AR+ +L LE R+ K
Sbjct: 1709 ARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRK 1768
Query: 940 SSEIRHQQSAEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMMAMVERHETQVRMLK 999
+++ Q S E + A N +A ++ +++++ KL A+ + ++ + L+
Sbjct: 1769 ATQQAEQLSNELATERSTAQKN-ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALE 1827
Query: 1000 QRIALLEEE 1008
+IA LEE+
Sbjct: 1828 AKIAQLEEQ 1836
Score = 82.0 bits (201), Expect = 3e-15
Identities = 211/1023 (20%), Positives = 396/1023 (38%), Gaps = 147/1023 (14%)
Query: 77 MNQLGADENGKISFQDFTRCRMQLVR-----EIRKEEVDLSAKSD--NSCTKK---LRDR 126
M Q D ++ ++ R ++QL + +I+K E ++ D N +K+ L +R
Sbjct: 955 MAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER 1014
Query: 127 IASWPTS-SDNSLGALSAARESWEYDSGARDLQ---SPDVQSQSALQKL---LEYGGSSL 179
I+ T+ ++ A + + +++S +L+ + +S+ L+KL LE S
Sbjct: 1015 ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1074
Query: 180 HQQAALHKLLTQSPHIGNSVGGSYLELANTLHSAALASLKGDIVELNKRLQQ-------- 231
H+Q A L Q + + EL AALA L +I + N L++
Sbjct: 1075 HEQIA--DLQAQIAELKMQLAKKEEEL-----QAALARLDDEIAQKNNALKKIRELEGHI 1127
Query: 232 TERERDLLEKKLAKAQCEQSH---------LMREHEDVQERTTLRYEERITELHSVIAEL 282
++ + DL ++ A+ + E+ L E ED + T + E R V L
Sbjct: 1128 SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTV-L 1186
Query: 283 NKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTADM 342
K +D T E + E+R + +Q+ E+ E + ++ +N+ T+ +
Sbjct: 1187 KKALDE---ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKR--AKANLDKNKQTLEKENA 1241
Query: 343 DNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTA-SEHCDLAIKTVEE 401
D +L RVL + V KK V E+ A +E D K E
Sbjct: 1242 DLAGEL-----RVLGQAKQEV-EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNE 1295
Query: 402 IEGVLGRDLYPNLAEERS-RWEKELAGLREENESLTAMLCSKEEELNRTKATMNAIREER 460
+E V G N AE ++ + K++A L + + +L + + + + EER
Sbjct: 1296 VESVTGM---LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER 1352
Query: 461 DRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINP--STGE-LSTSSSSNDIPIAKIA 517
+ L+ ++ E Q+++ + +L+ + + + ST E L I +
Sbjct: 1353 NSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLT 1412
Query: 518 ERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSA 577
++ + + + L E+ + V L +L+ Q F L +
Sbjct: 1413 QQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLE---KKQRKFDQLLAEEKN 1469
Query: 578 IS----------ESKIREFEVETERLNSRIEH-------LKSQNDLLTITLEECKSNAER 620
IS E++ RE E + L +E L+ N +L +E+ S+ +
Sbjct: 1470 ISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDD 1529
Query: 621 MSMLVGKYESNATALRLALQYSEQCIEAYELLLALAESEQ-------SLILGQFRAAGVG 673
+ V + E + AL ++ + +E E L E + + GQF
Sbjct: 1530 VGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER---D 1586
Query: 674 SSPGDQSGDENITQMLKRAHDCRKTAENAAK------ALLMKLDGSCGGAFAVAGCSVQP 727
D+ +E Q+ ++ H+ E+ K A KL+G A +++
Sbjct: 1587 LQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKG 1646
Query: 728 WESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYI-QQLKNDRAAVKLTMLELESIHID 786
E A D + ED + +D I K + K +L + D
Sbjct: 1647 REEAIKQLR----KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED 1702
Query: 787 PLSYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQ 846
L+ + R ++ DLE L EE+A + L+ EK+ LE ++
Sbjct: 1703 -LAAAERAR---KQADLEKEELA-------EELASSLSGRNALQDEKRRLEARI------ 1745
Query: 847 EQAYLVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKECADAASPALSLAELRTTCSE 906
+++EE+ E+ ++ + S D+ K A + LA R+T +
Sbjct: 1746 ------------AQLEEELEEEQGNMEAMS----DRVRKATQQAEQLSNELATERSTAQK 1789
Query: 907 NELAAEFTNAIRREKKLKARVQELVSALERLTKSS----EIRHQQSAEFVNDLKRANSNL 962
NE A + R+ K+L++++ E+ A++ KS+ E + Q E V R
Sbjct: 1790 NESARQ--QLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAA 1847
Query: 963 VAAYEKAKKKHQNKL------KKLESQMMAMVERHETQVRMLKQRIALLEEENSRPHTNE 1016
+ ++ KK + L +K+ Q E+ +V+ LK+++ EEE+ R + N
Sbjct: 1848 TKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANR 1907
Query: 1017 TSL 1019
L
Sbjct: 1908 RKL 1910
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 89.7 bits (221), Expect = 1e-17
Identities = 185/1029 (17%), Positives = 395/1029 (38%), Gaps = 123/1029 (11%)
Query: 60 LLMVCRQLN-MEESVAEIMNQLGADENGKISFQDFTRCRMQLVREIRKEEVDLSAKSDNS 118
LL V RQ M+ E+ + + ++ + QL E + L A+++
Sbjct: 844 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 903
Query: 119 C-TKKLRDRIASWPTSSDNSLGALSAARESWEYDSGARDLQSPDVQSQSALQKLLEYGGS 177
+++R R+A+ + L + A E E D G Q + + Q++L+
Sbjct: 904 AEAEEMRVRLAAKKQELEEILHEMEARLEE-EEDRG----QQLQAERKKMAQQMLDLEEQ 958
Query: 178 SLHQQAALHKLLTQSPHIGNSVGGSYLELANTLHSAALASLKGDIVELNKRLQQTERERD 237
++AA KL +L A + L+ +I+ ++ + + +ER
Sbjct: 959 LEEEEAARQKL----------------QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK 1002
Query: 238 LLEKKLAKAQCEQSHLMREHEDVQERTTL--RYEERITELHSVIAELNKKIDRLQGTTIR 295
LLE++++ ++L E E + T L ++E I+EL + + K L+ +
Sbjct: 1003 LLEERISDL---TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK 1059
Query: 296 EEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTADMDNCSDLNSELQRV 355
E + S+ +++ Q ++ E + + + + + A +N EL+
Sbjct: 1060 LEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGH 1119
Query: 356 LTGLENVVCGRK--KSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRD---L 410
++ L+ + + ++ ++ +E L T E + T +E+ ++ L
Sbjct: 1120 ISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVL 1179
Query: 411 YPNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKATMN---------------- 454
L EE E ++ +R+++ L + E+ R KA ++
Sbjct: 1180 KKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE 1239
Query: 455 --AIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIP 512
+ + + + + ++L+ ++Q +Q+ N ++ E+ + + +
Sbjct: 1240 LRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEA 1299
Query: 513 IAKIAERVKLSKTRSESSSSDRPVLGSEI-SSIGVSSSV--AEHLAHSLQD-CSNIQEIF 568
K + K + S + +L E + VS+ + E +SLQD E
Sbjct: 1300 EGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK 1359
Query: 569 QTLYSHGSAI------SESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERMS 622
Q L H S + S+ K+++F E L + + + + LT EE + +++
Sbjct: 1360 QNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLE 1419
Query: 623 MLVGKYESNATALRLALQYSEQCI-------EAYELLLALAESEQSLILGQFRAAGVGSS 675
+ + L + L Q + ++ LLA E S R +
Sbjct: 1420 KTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA-EEKNISSKYADERDRAEAEA 1478
Query: 676 PGDQSGDENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNS 735
++ ++ + L+ A + ++ E K L +++ V + + N
Sbjct: 1479 REKETKALSLARALEEALEAKEELERTNKMLKAEMED-----------LVSSKDDVGKNV 1527
Query: 736 HTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDVKPR 795
H S A E K + L+D +Q ++ + +++ M L+ D++ R
Sbjct: 1528 HELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG----QFERDLQAR 1583
Query: 796 GDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYL---- 851
+ + + L ++L + E+ + + Q L KK LE L E Q + +
Sbjct: 1584 DEQN--EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGRE 1641
Query: 852 ----------VHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPG--------KECADAASP 893
++ + E+E+ + R ++ K +E AA
Sbjct: 1642 EAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAER 1701
Query: 894 ALSLAELRTTCSENELAAEFT--NAIRREK-KLKARVQELVSALE-----------RLTK 939
A A+L ELA+ + NA++ EK +L+AR+ +L LE R+ K
Sbjct: 1702 ARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRK 1761
Query: 940 SSEIRHQQSAEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMMAMVERHETQVRMLK 999
+++ Q S E + A N +A ++ +++++ KL A+ + ++ + L+
Sbjct: 1762 ATQQAEQLSNELATERSTAQKN-ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALE 1820
Query: 1000 QRIALLEEE 1008
+IA LEE+
Sbjct: 1821 AKIAQLEEQ 1829
Score = 82.0 bits (201), Expect = 3e-15
Identities = 211/1023 (20%), Positives = 396/1023 (38%), Gaps = 147/1023 (14%)
Query: 77 MNQLGADENGKISFQDFTRCRMQLVR-----EIRKEEVDLSAKSD--NSCTKK---LRDR 126
M Q D ++ ++ R ++QL + +I+K E ++ D N +K+ L +R
Sbjct: 948 MAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER 1007
Query: 127 IASWPTS-SDNSLGALSAARESWEYDSGARDLQ---SPDVQSQSALQKL---LEYGGSSL 179
I+ T+ ++ A + + +++S +L+ + +S+ L+KL LE S
Sbjct: 1008 ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1067
Query: 180 HQQAALHKLLTQSPHIGNSVGGSYLELANTLHSAALASLKGDIVELNKRLQQ-------- 231
H+Q A L Q + + EL AALA L +I + N L++
Sbjct: 1068 HEQIA--DLQAQIAELKMQLAKKEEEL-----QAALARLDDEIAQKNNALKKIRELEGHI 1120
Query: 232 TERERDLLEKKLAKAQCEQSH---------LMREHEDVQERTTLRYEERITELHSVIAEL 282
++ + DL ++ A+ + E+ L E ED + T + E R V L
Sbjct: 1121 SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTV-L 1179
Query: 283 NKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTADM 342
K +D T E + E+R + +Q+ E+ E + ++ +N+ T+ +
Sbjct: 1180 KKALDE---ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKR--AKANLDKNKQTLEKENA 1234
Query: 343 DNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTA-SEHCDLAIKTVEE 401
D +L RVL + V KK V E+ A +E D K E
Sbjct: 1235 DLAGEL-----RVLGQAKQEV-EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNE 1288
Query: 402 IEGVLGRDLYPNLAEERS-RWEKELAGLREENESLTAMLCSKEEELNRTKATMNAIREER 460
+E V G N AE ++ + K++A L + + +L + + + + EER
Sbjct: 1289 VESVTGM---LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER 1345
Query: 461 DRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINP--STGE-LSTSSSSNDIPIAKIA 517
+ L+ ++ E Q+++ + +L+ + + + ST E L I +
Sbjct: 1346 NSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLT 1405
Query: 518 ERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSA 577
++ + + + L E+ + V L +L+ Q F L +
Sbjct: 1406 QQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLE---KKQRKFDQLLAEEKN 1462
Query: 578 IS----------ESKIREFEVETERLNSRIEH-------LKSQNDLLTITLEECKSNAER 620
IS E++ RE E + L +E L+ N +L +E+ S+ +
Sbjct: 1463 ISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDD 1522
Query: 621 MSMLVGKYESNATALRLALQYSEQCIEAYELLLALAESEQ-------SLILGQFRAAGVG 673
+ V + E + AL ++ + +E E L E + + GQF
Sbjct: 1523 VGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER---D 1579
Query: 674 SSPGDQSGDENITQMLKRAHDCRKTAENAAK------ALLMKLDGSCGGAFAVAGCSVQP 727
D+ +E Q+ ++ H+ E+ K A KL+G A +++
Sbjct: 1580 LQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKG 1639
Query: 728 WESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYI-QQLKNDRAAVKLTMLELESIHID 786
E A D + ED + +D I K + K +L + D
Sbjct: 1640 REEAIKQLR----KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED 1695
Query: 787 PLSYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQ 846
L+ + R ++ DLE L EE+A + L+ EK+ LE ++
Sbjct: 1696 -LAAAERAR---KQADLEKEELA-------EELASSLSGRNALQDEKRRLEARI------ 1738
Query: 847 EQAYLVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKECADAASPALSLAELRTTCSE 906
+++EE+ E+ ++ + S D+ K A + LA R+T +
Sbjct: 1739 ------------AQLEEELEEEQGNMEAMS----DRVRKATQQAEQLSNELATERSTAQK 1782
Query: 907 NELAAEFTNAIRREKKLKARVQELVSALERLTKSS----EIRHQQSAEFVNDLKRANSNL 962
NE A + R+ K+L++++ E+ A++ KS+ E + Q E V R
Sbjct: 1783 NESARQ--QLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAA 1840
Query: 963 VAAYEKAKKKHQNKL------KKLESQMMAMVERHETQVRMLKQRIALLEEENSRPHTNE 1016
+ ++ KK + L +K+ Q E+ +V+ LK+++ EEE+ R + N
Sbjct: 1841 TKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANR 1900
Query: 1017 TSL 1019
L
Sbjct: 1901 RKL 1903
>gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]
Length = 1498
Score = 87.0 bits (214), Expect = 8e-17
Identities = 210/994 (21%), Positives = 390/994 (39%), Gaps = 100/994 (10%)
Query: 56 SRNDLLMVCRQLNMEESVAEIMNQLGADENGKISFQDFTRCRMQLVREIRKEEVDLSAKS 115
SR D +C +++E S AE ++ K+ + + KE+ +L A+
Sbjct: 385 SRRD--SICSSVSLESSAAETQEEMLQVLKEKMRLEGQLEALSLEASQALKEKAELQAQL 442
Query: 116 DNSCTKKLRDRIASWPTSS---DNSLGALSAARES-WEYDSGARDLQSPDVQSQSALQKL 171
TK L+ ++ +S D+ + ++S W+ + DLQ+ +++++A L
Sbjct: 443 AALSTK-LQAQVECSHSSQQRQDSLSSEVDTLKQSCWDLERAMTDLQNM-LEAKNA--SL 498
Query: 172 LEYGGSSLHQQAALHKLLTQSPHIGNSVGGSYLELANTLHSAALASLKGDIVELNKRLQQ 231
+ +L+ + + S+ L NT+H L+ + L +LQQ
Sbjct: 499 ASSNNDLQVAEEQYQRLMAKVEDMQRSM----LSKDNTVHD-----LRQQMTALQSQLQQ 549
Query: 232 TERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITELHSVIAELNKKIDRLQG 291
+ ER L KL +Q E S L + Q++ L E R+ L +A + G
Sbjct: 550 VQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARV-RLQGEMAHIQVGQMTQAG 608
Query: 292 TTIREEDEYSELRSELSQSQHE-VNEDSR-----------SMDQDQTSVSIPENQSTMVT 339
+ E L +L+++QH + E R +DQ+ + I E + TMV
Sbjct: 609 LLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAK-TMVE 667
Query: 340 ADMDN-CSDLNSELQRVLTGLENVVCGRKK-SSCSLSVAEVDRHIEQLTTASEHCDLAIK 397
D+ + E +R+ ++ ++ L++ + D+ +E L EH DL +
Sbjct: 668 EDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQ--QEHLDLMKQ 725
Query: 398 TVEEIEGVLGRDLYPN-LAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKATMNAI 456
E + R+ + L + L L+ E S +C + E +A + A
Sbjct: 726 LTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAA 785
Query: 457 REERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKI 516
+ ++ L R R L+ + T L + + L +++ + KI
Sbjct: 786 KSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVE----HLQQETAALKKQMQKI 841
Query: 517 AERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGS 576
E+ K E+ D IS + + + L L++ QE+ Q +
Sbjct: 842 KEQFLQQKVMVEAYRRDATSKDQLISEL---KATRKRLDSELKELR--QELMQVHGEKRT 896
Query: 577 AISESKIREFEVETER-----LNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKYESN 631
A +E EV R L ++ + + D + L+ + + E+M V E+N
Sbjct: 897 AEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQM---VAVTEAN 953
Query: 632 ATALRLALQYSEQCIEAYELLLALAESEQSLI-LGQFRAAGVGSSPGDQSGDENITQMLK 690
AL+ ++ +Q E A+ E +Q + LG + EN +L
Sbjct: 954 E-ALKKQIEELQQ-----EARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILS 1007
Query: 691 RAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCS--VQPWES-LSSNSHTSTTSSTASSC 747
R A+ AA A L +L G + + +Q E+ L + SH+ T
Sbjct: 1008 RRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSKTL------- 1060
Query: 748 DTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAV 807
KE ++ + Q+L+ R V LELE D L R +RL+ N
Sbjct: 1061 ---LEKELQEVIALTSQELEESREKV----LELE----DELQESRGFRKKIKRLEESNKK 1109
Query: 808 LMQELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQ 867
L EL K ++ L L + LE L+ REA + ++ + EE+ ++
Sbjct: 1110 LALELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQRKEEE-DR 1168
Query: 868 RMRSLSSTSSGSKDKPGKECADAASPALSLAELRTTCSENELAAEFTNAIRREKKLKARV 927
+M+ L S +K KE ++ ++ A++ + A +K+L+A+
Sbjct: 1169 QMKHLVQALQASLEKE-KEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAK- 1226
Query: 928 QELVSALERLTKSSEIRH----QQSAEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQ 983
+ LV L+ +IR Q+ A+F +L A + L + +K+ +L K
Sbjct: 1227 EHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQL----QLLQKQLDEQLSKQPVG 1282
Query: 984 MMAM------VERHETQVRMLKQRIALLEEENSR 1011
M V++ E +++ LKQ++ L E++ +
Sbjct: 1283 NQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRK 1316
Score = 81.6 bits (200), Expect = 3e-15
Identities = 203/974 (20%), Positives = 387/974 (39%), Gaps = 170/974 (17%)
Query: 56 SRNDLLMVCRQLNMEESVAEIMNQ--LGADENGKISFQDFTRCRMQLVREIRKEEVDLSA 113
S NDL + Q + E M + L D Q T + QL ++++ E L++
Sbjct: 501 SNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQL-QQVQLERTTLTS 559
Query: 114 KSDNSCTKKLRDRIASWPTSSDNSLGALSAARESWEYDSGARDLQSPDVQSQSALQKLLE 173
K K + I+S + L+ A+E+ G +Q+ L + L+
Sbjct: 560 K-----LKASQAEISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLK 614
Query: 174 YGGSSLHQQAA--LHKLLTQSPHIGNSVGGSYLELANTLHSAALASLKGDIVE--LNKRL 229
SL QQ H+ + + I + G ++ + + +VE L +RL
Sbjct: 615 LENVSLSQQLTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVEEDLQRRL 674
Query: 230 QQTERERDLLEK---------------KLAKAQCEQS--HLMREHEDVQERTTLRYE--- 269
++ E ER+ L++ KL Q +Q L +EH D+ ++ TL E
Sbjct: 675 EEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQ 734
Query: 270 ---ERITELHSVIAELNKKIDRLQGTTIREEDEYSELRSE----------LSQSQHEVNE 316
+ + L + EL ++ LQG ED L++E + E++
Sbjct: 735 SREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKSGKEELDR 794
Query: 317 DSRSMDQ--DQTSVSIPENQSTMV--TADMDNCSDLNSELQRVLTGLENVVCGRKK--SS 370
+R +++ ++TS ++ + + + + +++ + L++ + ++ +K +
Sbjct: 795 GARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEA 854
Query: 371 CSLSVAEVDRHIEQLTTASEHCDLAIKTV-EEIEGVLGRDLYPNLAEERSRWEKELAGLR 429
D+ I +L + D +K + +E+ V G E SR +E+A +R
Sbjct: 855 YRRDATSKDQLISELKATRKRLDSELKELRQELMQVHGEKR--TAEAELSRLHREVAQVR 912
Query: 430 EENESLTAMLCSKEEE----------LNRTKATMNAIREERDRLRRRVRELQTRLQSVQA 479
+ L L S ++E L K M A+ E + L++++ ELQ +
Sbjct: 913 QHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEARKAIT 972
Query: 480 TGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVL-- 537
RL S + + E+ T + + + ++ R++ + E++ ++ L
Sbjct: 973 EQKQKMRRLGSD---LTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRA 1029
Query: 538 --GSEISSIGVSSSVAEHLAHSLQDCSNIQ-----EIFQTLYSHGSAISESKIREFEVET 590
GS SS+ + + + L LQ S+ + E+ + + + ES+ + E+E
Sbjct: 1030 QGGSSDSSLALHERI-QALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELED 1088
Query: 591 ERLNSR-----IEHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQC 645
E SR I+ L+ N L + LE K L G +SNA AL+
Sbjct: 1089 ELQESRGFRKKIKRLEESNKKLALELEHEKGK------LTGLGQSNA-----ALREHNSI 1137
Query: 646 IEAYELLLALAESEQSLILGQFRAAGVGSSPGDQSGD-ENITQMLKRAHDCRKTAENAAK 704
+E ALA+ E L+ + V ++ +++ Q L+ + + K N+ K
Sbjct: 1138 LET-----ALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLK 1192
Query: 705 ALLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQ 764
VA V E+ + H A+S + K++ Q + +Q
Sbjct: 1193 E-------------QVAAAKV---EAGHNRRHFK-----AASLELSEVKKELQAKEHLVQ 1231
Query: 765 QLKNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELKA 824
+L+ ++ L + QE+ + E+AE +A
Sbjct: 1232 KLQ----------------------------AEADDLQIREGKHSQEIAQFQAELAEARA 1263
Query: 825 QLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPG 884
QL LL+K+ L+ +LS + Q +E+LK EV +QKE+ ++SL ++ +
Sbjct: 1264 QLQLLQKQ---LDEQLSKQPVGNQ----EMENLKWEV-DQKEREIQSLKQQLDLTEQQGR 1315
Query: 885 KECADAASPALSLAELRTTCSENELAAEFTNAIRREK-KLKARVQELVSALERLTKSSEI 943
KE L+ SE E+A E + +++K L+A+V EL + ++ L
Sbjct: 1316 KELEGLQQ------LLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLL----- 1364
Query: 944 RHQQSAEFVNDLKR 957
QQ+ + DL+R
Sbjct: 1365 --QQNQQLKLDLRR 1376
Score = 73.9 bits (180), Expect = 7e-13
Identities = 149/816 (18%), Positives = 330/816 (40%), Gaps = 82/816 (10%)
Query: 236 RDLLEKKLAKAQCEQSHLMREHEDVQER--TTLRYEERITELHSVIAELNKKIDRLQGTT 293
+D+L+ A+ Q + + E ++ +++ E E + ++ K+ RL+G
Sbjct: 362 KDVLQAAAAEHQDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRLEGQL 421
Query: 294 IREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTADMDNCSDLNSELQ 353
E S+ E ++ Q ++ S + + + +++++D +L+
Sbjct: 422 EALSLEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCWDLE 481
Query: 354 RVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIE-GVLGRD-LY 411
R +T L+N++ + S S + L A E + VE+++ +L +D
Sbjct: 482 RAMTDLQNMLEAKNASLASSN--------NDLQVAEEQYQRLMAKVEDMQRSMLSKDNTV 533
Query: 412 PNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQ 471
+L ++ + + +L ++ E +LT+ L + + E+ +++ ++R+ + +E +
Sbjct: 534 HDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEI----SSLQSVRQWYQQQLALAQEAR 589
Query: 472 TRLQSVQA---TGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSE 528
RLQ A G + L + N S + T + + K R+ E
Sbjct: 590 VRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSM---KEKGRIAAQLQGIE 646
Query: 529 SSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEV 588
+ D+ +I + V E L L++ +E Q + + +A E ++ + ++
Sbjct: 647 ADMLDQEAAFMQIQE--AKTMVEEDLQRRLEEFEGERERLQRM-ADSAASLEQQLEQVKL 703
Query: 589 ETERLNSRIEHLKSQN-DL---LTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQ 644
+ + ++E L+ ++ DL LT+T E +S + + L Y+ L+ L +
Sbjct: 704 TLLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDE----LQARLGELQG 759
Query: 645 CIEAYELLLALAESEQSLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAK 704
+ E + L ++E+ ++ +AA +SG E + + +R + + +
Sbjct: 760 EAASREDTICLLQNEKIILEAALQAA--------KSGKEELDRGARRLEEGTEETSETLE 811
Query: 705 ALLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQ 764
L +L G + Q +L E + D I
Sbjct: 812 KLREELAIKSGQVEHLQ----QETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLIS 867
Query: 765 QLKNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELKA 824
+LK R + + EL ++ G+ + + E + L +E+ +++ MA+L+
Sbjct: 868 ELKATRKRLDSELKELR-------QELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEG 920
Query: 825 QLYLLEKEKKALELKLSTREAQE----------QAYLVHIEHLKSE----VEEQKEQRMR 870
L +KE+ +E L + + + +A IE L+ E + EQK++ R
Sbjct: 921 HLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQKMRR 980
Query: 871 SLSSTSSGSKDKPGKECADAASPALSLAELRTTCSENELAAEFTNAIRRE-------KKL 923
S +S K+ K A + + L+ + E A +R + L
Sbjct: 981 LGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLAL 1040
Query: 924 KARVQELVSALERLTKSSEIRHQQSAEFV----NDLKRANSNLVAAYEKAKKKH--QNKL 977
R+Q L + L+ ++ S + ++ E + +L+ + ++ ++ ++ + K+
Sbjct: 1041 HERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKKI 1100
Query: 978 KKLE--SQMMAMVERHET-QVRMLKQRIALLEEENS 1010
K+LE ++ +A+ HE ++ L Q A L E NS
Sbjct: 1101 KRLEESNKKLALELEHEKGKLTGLGQSNAALREHNS 1136
Score = 41.6 bits (96), Expect = 0.004
Identities = 102/534 (19%), Positives = 210/534 (39%), Gaps = 73/534 (13%)
Query: 107 EEVDLSAKSDNSCTKKLRDRIASWPTSSDNSLGALSAARESWEYDSGARDLQSPDVQSQS 166
EE+ A+ + K+ R+ S TS+ + A E+ +R LQ ++
Sbjct: 961 EELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYEN-AVGILSRRLQEALAAKEA 1019
Query: 167 A---LQKLLEYGGSS-----LHQQAALHKLLTQSPHIGNSVGGSYLELANTLHSAALASL 218
A L +L GGSS LH++ + Q+ ++ L+ L S L
Sbjct: 1020 ADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEES 1079
Query: 219 KGDIVELNKRLQQTERERDLLE------KKLA-KAQCEQSHL---------MREHEDVQE 262
+ ++EL LQ++ R ++ KKLA + + E+ L +REH + E
Sbjct: 1080 REKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSILE 1139
Query: 263 RTTLRYEERITELHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMD 322
+ E + +L+ ++Q R+E+E +++ + Q + ++ ++
Sbjct: 1140 TALAKREADLVQLNL----------QVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVN 1189
Query: 323 QDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHI 382
+ V+ + ++ S SE+++ L E++V + + L + E +H
Sbjct: 1190 SLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIRE-GKHS 1248
Query: 383 EQLTTASEHCDLAIKTVEEIEGVLGRDLYPNLAEERSRWEKELAGLREENESLTAMLCSK 442
+++ A ++ ++ L L K+ G +E E+L + K
Sbjct: 1249 QEIAQFQAELAEARAQLQLLQKQLDEQL-----------SKQPVG-NQEMENLKWEVDQK 1296
Query: 443 EEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRP---INPST 499
E E+ K ++ ++ R+ + LQ LQ+V++ + L+ T + +
Sbjct: 1297 EREIQSLKQQLDLTEQQG---RKELEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKV 1353
Query: 500 GELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQ 559
EL + + + + +++KL R + + P G +SS +
Sbjct: 1354 SELKNNMKT----LLQQNQQLKLDLRRGAAKTRKEPK--------GEASSSNPATPIKIP 1401
Query: 560 DCSNIQEIFQTLYSHGSAISESKIREFEVETERLNSRIEHLKSQNDLLTITLEE 613
DC + + L A+S+ ++ LNS ++ LK + D L +EE
Sbjct: 1402 DCPVPASLLEELLRPPPAVSKEPLK-------NLNSCLQQLKQEMDSLQRQMEE 1448
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 85.9 bits (211), Expect = 2e-16
Identities = 169/924 (18%), Positives = 354/924 (38%), Gaps = 132/924 (14%)
Query: 108 EVDLSA-KSDNSCTKKLRDRIASWPTSSDNSLGALSAARESW--EYDSGARDLQSPDVQS 164
E DL +++ C +K + + L +++ R E D+ ++ + D S
Sbjct: 1922 EADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLS 1981
Query: 165 QSALQKLLEYGGSSLHQQAALHKLLTQSPHIGNSVGGSYLELANTLHSAALASLKGDIVE 224
+ +K E HQ LH + + EL TL S LK D
Sbjct: 1982 EKMKEKTQELES---HQSECLHCIQVAEAEVKEKT-----ELLQTLSSDVSELLK-DKTH 2032
Query: 225 LNKRLQQTERERDLL-------EKKLAKAQCEQSHLMREHEDVQERTTLRYEERITELHS 277
L ++LQ E++ L E ++A+ E+ L++E E +Q R + E++ +
Sbjct: 2033 LQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKA 2092
Query: 278 VIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTM 337
+ A L +K E LS +Q EV++ R +++ + + E +
Sbjct: 2093 LEAALVEK---------------GEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLH 2137
Query: 338 VTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDL-AI 396
+ + N L+ + LE L ++E ++ + L + ++ +
Sbjct: 2138 IAEKLKERERENDSLKDKVENLER----------ELQMSEENQELVILDAENSKAEVETL 2187
Query: 397 KTVEEIEGVLGRDLYPNLAEERSRWEKELAGLREENESLTAMLCSKE---EELNRTKATM 453
KT E +A +E +L LR E E+LT + K+ EL++ ++
Sbjct: 2188 KTQIE-----------EMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSF 2236
Query: 454 NAIREERDRLRRRVRE-LQTRLQSVQATGPSSPGRLTSTNRPINPSTGE---LSTSSSSN 509
++ EE+++ +++E +T ++ +Q +L N + G+ + + S
Sbjct: 2237 KSLLEEKEQAEIQIKEESKTAVEMLQ-------NQLKELNEAVAALCGDQEIMKATEQSL 2289
Query: 510 DIPIAKIAE-RVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIF 568
D PI + + R + K R+ + ++ L + + S A+ L +++ EI
Sbjct: 2290 DPPIEEEHQLRNSIEKLRARLEADEKKQL-CVLQQLKESEHHADLLKGRVENLERELEIA 2348
Query: 569 QTLYSHGSAISESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKY 628
+T H + +E+ + E E L ++IE + L + + +S E ++ + K
Sbjct: 2349 RTNQEHAALEAENS----KGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKE 2404
Query: 629 ESNATALRLALQYSEQCIEAYELLLALAESEQSLILGQFRAAGVGSSPGDQSGDENITQM 688
+ + L + E ++ E EQ + Q + + Q+ + + +
Sbjct: 2405 QERISELEIINSSFENILQ---------EKEQEKV--QMKEKSSTAMEMLQTQLKELNER 2453
Query: 689 LKRAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCD 748
+ H+ + A KA L +Q + +N +S +
Sbjct: 2454 VAALHN----DQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQE 2509
Query: 749 TEFTKEDEQRLKDYIQQLKN---DRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLEN 805
E K+ ++ + I +LKN D+ + + ++E H Q L+L N
Sbjct: 2510 VEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEH---------QLWKEQNLELRN 2560
Query: 806 AV--LMQELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEE 863
L Q++ ++ + A L+ L +L+ K LE +L + + +++ + + ++ E
Sbjct: 2561 LTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETE 2620
Query: 864 QKEQRMRSLSSTSSGSKDKPGKECADAASPALSLAELRTTCSENELAAEFTNAIRREKKL 923
+ + T+ ++ G++ N LA E + K
Sbjct: 2621 LQREMHEMAQKTAELQEELSGEK--------------------NRLAGELQLLLEEIKSS 2660
Query: 924 KARVQELVSALERLTKSSEIRHQQSAEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQ 983
K +++EL L KS + H+ E ++ + +A+KKHQ L Q
Sbjct: 2661 KDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQ 2720
Query: 984 MMAMVERHETQVRMLKQRIALLEE 1007
+E +++ ++++ EE
Sbjct: 2721 -------YEVEIQTYREKLTSKEE 2737
Score = 77.4 bits (189), Expect = 6e-14
Identities = 164/864 (18%), Positives = 363/864 (42%), Gaps = 98/864 (11%)
Query: 190 TQSPHIGNSVGGSYLELANTLHSAALASLKGDIVELNKRLQQTERERDLLEKKLAKAQC- 248
+ SPH+ + + EL N ++ L L+G E+ ++ + + + LEK AK +
Sbjct: 274 SSSPHLLDQLKAQNQELRNKINELELR-LQGHEKEMKGQVNKFQELQLQLEK--AKVELI 330
Query: 249 EQSHLMREHEDVQERTTLRYEERITELHSVIAELNKKIDRLQGTTIREEDEYSELRSELS 308
E+ ++ + D RTT +Y++ T+ ++ +L K + L E L ++
Sbjct: 331 EKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIK 390
Query: 309 QSQHEVNED-SRSMDQDQT--------------SVSIPENQSTMVTADMDNCSDLNSELQ 353
+ + E E+ SR QT + +N ++ A++D + + +L+
Sbjct: 391 EKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLE 450
Query: 354 RVLTGLENVVCGRKKS--SCSLSVAEVDRHIEQL----TTASEHCDLAIKTVEEIEGVLG 407
L + +C +++ + + E+ R +E++ H + + V +E L
Sbjct: 451 NNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAEL- 509
Query: 408 RDLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRV 467
N+ + ++ + ++ +N S ML +E++N+ + ++ ++L+ V
Sbjct: 510 ----KNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTL-----EKLKLAV 560
Query: 468 RELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRS 527
+L+ + Q + N ++ + E S+ ++ K E +K KT
Sbjct: 561 ADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELK-KKEYEELKEEKTLF 619
Query: 528 ESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFE 587
S+ L +++ S ++ + H L+ C Q+I Y+ ++R E
Sbjct: 620 SCWKSENEKLLTQMES--EKENLQSKINH-LETCLKTQQIKSHEYN-------ERVRTLE 669
Query: 588 VETERLNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIE 647
++ E L+ I +L + D ++ +E ++++ + + ++ + + + C++
Sbjct: 670 MDRENLSVEIRNLHNVLDSKSVEVE-----TQKLAYMELQQKAEFSDQKHQKEIENMCLK 724
Query: 648 AYELLLALAESEQSLILGQFRAAGVGSSPGDQSGD-ENITQMLKRAHDCRKTAENAAKAL 706
+L + + E L L D + E++ +LK T E+ ++L
Sbjct: 725 TSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSL 784
Query: 707 L-MKLDGSCGGAFA--VAGCSVQPWE----SLSSNSHTSTTSSTASSCDT-EFTKEDEQR 758
L + +FA + P E L ++ ++ + D+ EF+ E +++
Sbjct: 785 LAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQ 844
Query: 759 LKDYIQ----QLKNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMA 814
+ +Q +L + ++ +++ E +H ++ SQR+ + L ++ A
Sbjct: 845 MNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVA------ETSQRI----SKLQEDTSA 894
Query: 815 MKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLK--SEVEEQKEQRMRSL 872
+ +AE + L EKE + L K+ T +A+ I+ LK + + E + ++ L
Sbjct: 895 HQNVVAETLSALENKEKELQLLNDKVETEQAE-------IQELKKSNHLLEDSLKELQLL 947
Query: 873 SSTSSGSKDKPGKECADAASPALSLAELRTTCSENELAAEFTNAIRREK-KLKARVQELV 931
S T S K KE + S L+ E+ EN E ++ +EK L + +
Sbjct: 948 SETLSLEK----KEMSSIIS--LNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFA 1001
Query: 932 SALERLTKS-SEIRHQQSAEFVNDLKR------ANSNLVAAYEKAKKKHQNKLKKLESQM 984
+ ++ KS SE+ Q E + L+R A +L Y+ A++K+ +KL+ L ++
Sbjct: 1002 NYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKN-SKLECLLNEC 1060
Query: 985 MAMVERHETQVRMLKQRIALLEEE 1008
++ E + ++ LK+ A +E
Sbjct: 1061 TSLCENRKNELEQLKEAFAKEHQE 1084
Score = 70.5 bits (171), Expect = 8e-12
Identities = 145/847 (17%), Positives = 338/847 (39%), Gaps = 91/847 (10%)
Query: 223 VELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQE-RTTLRYEERITELHSVIAE 281
+EL K + + ++E L +KL C+ L++ E + + L + +
Sbjct: 1826 IELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDN 1885
Query: 282 LNKKIDRLQGTTIREEDEYSELRSELSQSQHE----------VNEDSRSMDQD----QTS 327
+ K D + + E+E S +RSE + +HE V + +++D Q
Sbjct: 1886 VAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKV 1945
Query: 328 VSIPENQSTMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTT 387
+ E + ++VT++ + + + T L+ + K+ + E++ H +
Sbjct: 1946 IVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKT-----QELESHQSECLH 2000
Query: 388 ASEHCDLAIKTVEEIEGVLGRDLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEELN 447
+ + +K E+ L D+ L ++++ +++L L +++++L+ C E ++
Sbjct: 2001 CIQVAEAEVKEKTELLQTLSSDV-SELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIA 2059
Query: 448 RTKATMNAIREERDRLRRRVRE-------LQTRLQSVQATGPSSPGRLTSTNRPINP--- 497
+ + +E + L+ R+ E + L++ RL+ST ++
Sbjct: 2060 QLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRR 2119
Query: 498 STGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHS 557
+L +++ IAE++K + ++S L E+ + +
Sbjct: 2120 GIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELV------ 2173
Query: 558 LQDCSNIQEIFQTLYSHGSAISESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSN 617
+ D N + +TL + ++ S ++ FE++ L S E+L Q ++E +
Sbjct: 2174 ILDAENSKAEVETLKTQIEEMARS-LKVFELDLVTLRSEKENLTKQ-------IQEKQGQ 2225
Query: 618 AERMSMLVGKYESNATALRLA-LQYSEQCIEAYELLLALAESEQSLILGQFRAAGVGSSP 676
+ L+ ++S A +Q E+ A E+L Q L + AA G
Sbjct: 2226 LSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEML-----QNQLKELNEAVAALCGDQE 2280
Query: 677 GDQSGDENITQMLKRAHDCRKTAENAAKAL----------LMKLDGSCGGAFAVAGCSVQ 726
++ ++++ ++ H R + E L L +L S A + G
Sbjct: 2281 IMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKG---- 2336
Query: 727 PWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIHID 786
E+L + T+ ++ + E +K + + LK I+ + ++L ++ + S +
Sbjct: 2337 RVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKEN 2396
Query: 787 PLSYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQ----LYLLEKEKKALELKLST 842
+ K + L++ N+ L ++E ++K + + +L+ + K L +++
Sbjct: 2397 LTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAA 2456
Query: 843 REAQEQAYLVHIEHLKSEV---EEQKEQRMRSLSSTSSG------------SKDKPGKEC 887
++A ++L S+V E +K Q ++ L + + + GK+
Sbjct: 2457 LHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQK 2516
Query: 888 ADAASPALSLAELRTTCSENELAAEFTNAIRRE----KKLKARVQELVSALERLTKSSEI 943
+ +S L+ + E + + E K+ ++ L LE+ + +
Sbjct: 2517 LEKKDEEIS--RLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQS 2574
Query: 944 RHQQSAEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMMAMVERHETQVRMLKQRIA 1003
++ + + L+ + NL E K + ++K+ ++M A + ++ + Q+ A
Sbjct: 2575 KNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKV-NKMTAKETELQREMHEMAQKTA 2633
Query: 1004 LLEEENS 1010
L+EE S
Sbjct: 2634 ELQEELS 2640
Score = 63.5 bits (153), Expect = 9e-10
Identities = 151/741 (20%), Positives = 278/741 (37%), Gaps = 134/741 (18%)
Query: 217 SLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITELH 276
SLK + L + LQ +E ++L+ ++ E L + E++ R+ +E + L
Sbjct: 2151 SLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMA-RSLKVFELDLVTLR 2209
Query: 277 SVIAELNKKIDRLQGT------------TIREEDEYSELRS--------ELSQSQ-HEVN 315
S L K+I QG ++ EE E +E++ E+ Q+Q E+N
Sbjct: 2210 SEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELN 2269
Query: 316 EDSRSMDQDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSV 375
E ++ DQ + E + ++ L + ++++ LE KK C L
Sbjct: 2270 EAVAALCGDQEIMKATEQS---LDPPIEEEHQLRNSIEKLRARLE---ADEKKQLCVL-- 2321
Query: 376 AEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPNLAEERSRWEKELAGLREEN--- 432
+QL + H DL VE +E L E +R +E A L EN
Sbjct: 2322 -------QQLKESEHHADLLKGRVENLEREL----------EIARTNQEHAALEAENSKG 2364
Query: 433 --ESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTS 490
E+L A + + L + + IR E++ L +++ Q R+ ++ S L
Sbjct: 2365 EVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQE 2424
Query: 491 TNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSV 550
+ + ST+ + ++ ERV E+ + L S++ + + +
Sbjct: 2425 KEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKA- 2483
Query: 551 AEHLAHSLQDCSN------------IQEIF---QTLYSHGSAISE------------SKI 583
L L + N IQE+ Q L IS SK+
Sbjct: 2484 --QLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKL 2541
Query: 584 REFEVE--------------TERLNSRIEHLKSQNDLLTITLEECKSNAERMS-----ML 624
+ E E T L +I+ L+S+N L TLE +S+ + +
Sbjct: 2542 SQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTK 2601
Query: 625 VGKYESNATALRLALQYSEQCIEAYELLLALAESEQSLILGQFRAAGVGS-------SPG 677
+ K ++ + +E E +E+ AE ++ L + R AG S
Sbjct: 2602 MDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSK 2661
Query: 678 DQSGDENITQM-LKRAHDCR---------KTAENAAKALLMKLDGSCGGAFAVAGCSVQP 727
DQ + + LK++ DC K E A+ L + + + Q
Sbjct: 2662 DQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQY 2721
Query: 728 WESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDP 787
+ + T+ S K + LK ++L N A + EL+ +D
Sbjct: 2722 EVEIQTYREKLTSKEECLSSQ----KLEIDLLKSSKEELNNSLKATTQILEELKKTKMDN 2777
Query: 788 LSYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLE--KEKKALELKLSTREA 845
L Y + + +++R + +L++ ++EE L+ +L L+ +EK+ + T+
Sbjct: 2778 LKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTK-- 2835
Query: 846 QEQAYLVHIEHLKSEVEEQKE 866
++ L +E++E KE
Sbjct: 2836 --------VDELTTEIKELKE 2848
Score = 61.2 bits (147), Expect = 5e-09
Identities = 142/696 (20%), Positives = 277/696 (39%), Gaps = 87/696 (12%)
Query: 359 LENVVCGRKKSSCSLSVAEVDRHIEQLTTAS-EHCDLAIKTVEEIEGVLG---------- 407
LE +V KK + LS E+L S +H +L ++ VE EG+
Sbjct: 1828 LEKIVGELKKENSDLS--------EKLEYFSCDHQEL-LQRVETSEGLNSDLEMHADKSS 1878
Query: 408 -RDLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRR 466
D+ N+A+ W++ + E + + S E E +A + ++ E+ L +
Sbjct: 1879 REDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKD 1938
Query: 467 VRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTR 526
Q + ++ L+ N GEL T S + +++E++K
Sbjct: 1939 NENKQKVIVCLEE-------ELSVVTSERNQLRGELDTMSKKTTA-LDQLSEKMKEKTQE 1990
Query: 527 SESSSSDR----PVLGSEISS-IGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISES 581
ES S+ V +E+ + +++ ++ L+D +++QE Q+L A+S +
Sbjct: 1991 LESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLT 2050
Query: 582 KIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQY 641
K E E + +LN E L +++ L L E S+ E++++ + AL AL
Sbjct: 2051 KC-ELENQIAQLNKEKELLVKESESLQARLSE--SDYEKLNV--------SKALEAAL-- 2097
Query: 642 SEQCIEAYELLLALAESEQSLILGQFRAAGVGSS----PGDQSGDENITQMLK---RAHD 694
+E E L L+ +++ + Q R G+ D+ +I + LK R +D
Sbjct: 2098 ----VEKGEFALRLSSTQEEV--HQLRR-GIEKLRVRIEADEKKQLHIAEKLKEREREND 2150
Query: 695 CRKT-AENAAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTK 753
K EN + L M + A S E+L + S D +
Sbjct: 2151 SLKDKVENLERELQMSEENQ-ELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLR 2209
Query: 754 EDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLMQELM 813
+++ L IQ+ + + + + +S+ + K + + Q + E+ ++ L
Sbjct: 2210 SEKENLTKQIQEKQGQLSELDKLLSSFKSL------LEEKEQAEIQ-IKEESKTAVEMLQ 2262
Query: 814 AMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLS 873
+E+ E A L ++ KA E L +E IE L++ +E +++++ L
Sbjct: 2263 NQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQ 2322
Query: 874 STSSGSKDKPGKECADAASPALSLAELR---TTCSENELAAEFTNAIRREKKLKARVQEL 930
K + AD + E ++ A E N+ + LKA+++ +
Sbjct: 2323 QL------KESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGM 2376
Query: 931 VSALERLTKSSEIRHQQSAEFVNDLKRANSNLV------AAYEKA-KKKHQNKLKKLESQ 983
+L L + N+L++ + +++E ++K Q K++ E
Sbjct: 2377 TQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKS 2436
Query: 984 MMAMVERHETQVRMLKQRIALLEEENSRPHTNETSL 1019
AM E +TQ++ L +R+A L + E +L
Sbjct: 2437 STAM-EMLQTQLKELNERVAALHNDQEACKAKEQNL 2471
Score = 51.6 bits (122), Expect = 4e-06
Identities = 153/811 (18%), Positives = 318/811 (39%), Gaps = 77/811 (9%)
Query: 218 LKGDIVELNK-RLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTL--RYEERITE 274
L D VE + +Q+ ++ LLE L + Q L E +++ +L R E +T+
Sbjct: 915 LLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQ 974
Query: 275 LHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRS-----MDQDQTSVS 329
+ + E+N +++ + I++ + ++ E +S E+++ + + + + + +
Sbjct: 975 ENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGN 1034
Query: 330 IPENQSTMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTT-- 387
E+ S A + NS+L+ +L ++ RK L A H E LT
Sbjct: 1035 AYEDLSQKYKAAQEK----NSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLA 1090
Query: 388 -ASEHCDLAIKTVEEIEGVLGRDLYPN-----------------LAEERSRWEKELAGLR 429
A E + +E ++ L ++ N L EE+++ +KE+ L
Sbjct: 1091 FAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLL 1150
Query: 430 EENESLTAMLCSKEEELN-RTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRL 488
+ENE L ++ +K E N ++ N+++E + + Q L+ + + S +L
Sbjct: 1151 QENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQL 1210
Query: 489 TSTNRPINPSTGELSTSSSSNDI---PIAKIAERVKLSKTRSESSSSDRPVLGSEISSIG 545
+ +L S + + I ++ S + S + EI +
Sbjct: 1211 VQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEE 1270
Query: 546 VSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISE----SKIREFEVETERLNSRIEHLK 601
S L+ S D +++Q QT + + + + + ++E+ TE +SR E +
Sbjct: 1271 KYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECIT 1330
Query: 602 SQNDL---LTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQC---------IEAY 649
+ + + L E K + +L G+ + Q +EQ +Y
Sbjct: 1331 ATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSY 1390
Query: 650 ELLLALAESEQSLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAEN-AAKALLM 708
E L L++ E + + + + + + QM + + + ++ A+ L++
Sbjct: 1391 E-HLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVL 1449
Query: 709 KLDGSCGGAFAVAGCSVQPWESL---SSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQ 765
+ V + E L S+S +SS +S D+ F + ++ D +
Sbjct: 1450 STNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGD-MSL 1508
Query: 766 LKNDRAAVKLTMLELESIHIDPLSYDVKPRGDS--------QRLDLENAVLMQELMAMKE 817
L N AV ++ + L + R ++ + L+ V Q L ++E
Sbjct: 1509 LSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEE 1568
Query: 818 EMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSS 877
+M ++Q + KE + LE LS+ E QE ++ L+ + + EQ + L+S +
Sbjct: 1569 KM---ESQGIMKNKEIQELEQLLSS-ERQE------LDCLRKQYLSENEQWQQKLTSVTL 1618
Query: 878 GSKDKPGKECADAASPALSLAELRTTCSENELAAEFTNAIRREKKLKARVQELVSALERL 937
+ K E +L L R +L++ I E ++ R + + E
Sbjct: 1619 EMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHT 1678
Query: 938 TKSSEIRHQQSAEFVNDLKRANSNLVAAYEK 968
++++E + + D K A +L EK
Sbjct: 1679 SETTERTPKHDVHQICD-KDAQQDLNLDIEK 1708
Score = 50.1 bits (118), Expect = 1e-05
Identities = 149/797 (18%), Positives = 305/797 (38%), Gaps = 108/797 (13%)
Query: 256 EHEDVQERTTLRYEERITELHSVIAELNKKIDR-LQGTTIREEDEYSELRSELSQSQHEV 314
++ED++E+ EER V A KK + L T+ D ++H+
Sbjct: 163 KYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDI----------ARHQA 212
Query: 315 NEDSRSMDQDQTSVSIPEN-QSTMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSL 373
+ S Q++T + N Q T + D + S + E Q V + G++ ++ S
Sbjct: 213 SSSVFSWQQEKTPSHLSSNSQRTPIRRDF-SASYFSGE-QEVTPSRSTLQIGKRDANSSF 270
Query: 374 SVAEVDRHI-EQLTTASEHCDLAIKTVE-EIEGVLGRDLYPNLAEERSRWEKELAGLREE 431
H+ +QL ++ I +E ++G EKE+ G +
Sbjct: 271 FDNSSSPHLLDQLKAQNQELRNKINELELRLQG----------------HEKEMKGQVNK 314
Query: 432 NESLTAMLCSKEEELNRTKATMNAIREE------------------RDRLRRRVRELQTR 473
+ L L + EL + +N R+E +L++ +L +
Sbjct: 315 FQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQ 374
Query: 474 LQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSD 533
Q+ ++ S ++ + S + D ++ R+ ++++ +
Sbjct: 375 RQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHN- 433
Query: 534 RPVLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVETERL 593
VL +E+ + +SV + L + N++E Q L A S+I+E E L
Sbjct: 434 --VLQAELDKL---TSVKQQLEN------NLEEFKQKLCRAEQAFQASQIKENE-----L 477
Query: 594 NSRIEHLKSQNDLLTITLEE-----CKSNAERMSMLVGKYESNATALRLALQYSEQCIEA 648
+E +K +N+LL E+ C AE ++ +S A + + + Q
Sbjct: 478 RRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETML 537
Query: 649 YELLLALAESEQSLILGQFRAAGVGSSPGDQSGDENITQM---LKRAHDCRKTAENAAKA 705
+L + + E SL L + + A + + + +++ +D E +KA
Sbjct: 538 RDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKA 597
Query: 706 LLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASS---CDTEFTKEDEQRLKDY 762
LL L+ + +E L + + + E KE+ Q ++
Sbjct: 598 LLSALE-----------LKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINH 646
Query: 763 I------QQLKNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAMK 816
+ QQ+K+ ++ LE++ ++ ++ DS+ +++E L + K
Sbjct: 647 LETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQK 706
Query: 817 EEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTS 876
E ++ K Q KE + + LK S Q + ++ L +E+ + K++ + L +
Sbjct: 707 AEFSDQKHQ-----KEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMD-KDRCYQDLHAEY 760
Query: 877 SGSKDKPGKECADAASPALSLAELRTTCSENELAAEFTNAIRREKKLKARVQELVSALER 936
+D + A + L + + F N I + + + E ++
Sbjct: 761 ESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQ 820
Query: 937 LTKSSEIRHQQ--SAEF-VNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMMAMVERHET 993
K+S I + S EF + K+ NS+L +K ++ ++E +M + H++
Sbjct: 821 SPKNSAILQNRVDSLEFSLESQKQMNSDL----QKQCEELVQIKGEIEENLMKAEQMHQS 876
Query: 994 QVRMLKQRIALLEEENS 1010
V QRI+ L+E+ S
Sbjct: 877 FVAETSQRISKLQEDTS 893
Score = 47.8 bits (112), Expect = 5e-05
Identities = 124/625 (19%), Positives = 230/625 (36%), Gaps = 96/625 (15%)
Query: 422 EKELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATG 481
E +L L++E + L S E L + K + + E L+R + L +S++ T
Sbjct: 24 EGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICESLEKTK 83
Query: 482 PSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEI 541
L +N G+L++ I K+ + +K K+ E
Sbjct: 84 QKISHELQVKESQVNFQEGQLNSGKKQ----IEKLEQELKRCKSELER------------ 127
Query: 542 SSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFE-------VETERLN 594
S A+ SL C+ Q+IF T + S SK + + E +RL
Sbjct: 128 -----SQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLE 182
Query: 595 SRIEHL---KSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYEL 651
+ ++ L K+ L T+ + S V ++ T L+ S++ +
Sbjct: 183 AEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLS-SNSQRTPIRRDF 241
Query: 652 LLALAESEQSLILG----QFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAKALL 707
+ EQ + Q SS D S ++ LK + + N + L
Sbjct: 242 SASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRL 301
Query: 708 MKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTT-----SSTASSCDTEFTKEDEQRLKDY 762
+ G V ++ L + + C E + Q
Sbjct: 302 QGHEKEMKG-------QVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQ----- 349
Query: 763 IQQLKNDRAAVKLTMLELESIHIDPLSYDV---KPRGDSQRLDLENAVLMQELMAMKEEM 819
D+A+ K T LE + + L+ D+ + +S R LE + +E +EE+
Sbjct: 350 -----YDQASTKYTALEQK---LKKLTEDLSCQRQNAESARCSLEQKIKEKE-KEFQEEL 400
Query: 820 AELKAQLYLLEKEKKALELKLSTREAQE--------QAYLVHIEHLKSEVEEQKEQRMRS 871
+ + L++E ++ +L T+E Q+ QA L + +K ++E E+ +
Sbjct: 401 SRQQRSFQTLDQECIQMKARL-TQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQK 459
Query: 872 LSSTSSGSKDKPGKECADAASPALSLAELRTTCSENELAAEFTNAIRREKKLKARVQELV 931
L A+ A A + E S E+ E N ++ + KAR V
Sbjct: 460 LCR-------------AEQAFQASQIKENELRRSMEEMKKE-NNLLKSHSEQKARE---V 502
Query: 932 SALERLTKSSEIRHQQSAEFVNDLKRANSN----LVAAYEKAKKKHQN-KLKKLESQMMA 986
LE K+ + QS F ++K N++ L EK ++ + L+KL+ +
Sbjct: 503 CHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVAD 562
Query: 987 MVERHETQVRMLKQRIALLEEENSR 1011
+ ++ + +LK+R +E+ N +
Sbjct: 563 LEKQRDCSQDLLKKREHHIEQLNDK 587
Score = 42.0 bits (97), Expect = 0.003
Identities = 164/879 (18%), Positives = 332/879 (37%), Gaps = 109/879 (12%)
Query: 205 ELANTLHSAALASLKGDIVELNKRLQQTERERDLLEKKLA--KAQCEQSHLM----REHE 258
E++ ++A L L+ + +LQ++E+E++ L+ +L + E S+L +E
Sbjct: 1200 EISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEIS 1259
Query: 259 DVQERTTLRYEERITELHSVIAELN-------------KKIDRLQGTTIREEDEYSELRS 305
+++ E+ I+ H + N K++ L+ + E EL +
Sbjct: 1260 GLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVT 1319
Query: 306 ELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLENVVCG 365
EL+ S+ E +R M ++ + N+ ++ D+ L+ EL + G E
Sbjct: 1320 ELNDSRSECITATRKMAEEVGKLL---NEVKILN---DDSGLLHGELVEDIPGGEFGEQP 1373
Query: 366 RKKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPNLAEERSRWEKEL 425
++ SL+ + E LT + + + ++E +
Sbjct: 1374 NEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQE----------------------KF 1411
Query: 426 AGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSP 485
L+ E++ L C +++ + +++++ E L +R Q L G
Sbjct: 1412 LSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEE- 1470
Query: 486 GRLTSTNRPINPSTGELST--SSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEISS 543
G + S + P + LS+ SS + + + LS S++ +
Sbjct: 1471 GLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQ-----CSVDE 1525
Query: 544 IGVSSSVAEHL---------AHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVETERLN 594
+ SS E+L A +++ ++ E+++ ES+ E + L
Sbjct: 1526 VFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELE 1585
Query: 595 SRIEHLKSQNDLLTIT-LEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYELLL 653
+ + + D L L E + ++++ + + ES A + + +E L L
Sbjct: 1586 QLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQL 1645
Query: 654 -ALAESEQSLILGQFRAAGVGSSPGDQSGDENITQMLKRA--HD----CRKTA------- 699
L S +SL+ A G + E+ ++ +R HD C K A
Sbjct: 1646 QGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLD 1705
Query: 700 -ENAAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASS------CDTEFT 752
E + +K G C G + P E + S + + S D
Sbjct: 1706 IEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGN 1765
Query: 753 KEDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLMQE- 811
+ED L+ +++ N+ + L ++E ++ L ++K +L++ + +QE
Sbjct: 1766 QEDIHNLQLRVKETSNENLRL-LHVIEDRDRKVESLLNEMK--------ELDSKLHLQEV 1816
Query: 812 -LMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHI---EHLKSEVEEQKEQ 867
LM E EL+ + L+KE L KL Q L + E L S++E ++
Sbjct: 1817 QLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADK 1876
Query: 868 RMRSLSSTSSGSKDKPGKECADAASPALSLAELRTTCSENE-------LAAEFTNAIRRE 920
R + + KE LS E+E L T + E
Sbjct: 1877 SSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLE 1936
Query: 921 KKLKARVQELVSALERLTKSSEIRHQQSAEFVNDLKRANSNLVAAYEKAKKKHQNKLKKL 980
K + + + +V E L+ + R+Q E ++ + + + L EK K+K Q +L+
Sbjct: 1937 KDNENKQKVIVCLEEELSVVTSERNQLRGE-LDTMSKKTTALDQLSEKMKEKTQ-ELESH 1994
Query: 981 ESQMMAMVERHETQVRMLKQRIALLEEENSRPHTNETSL 1019
+S+ + ++ E +V+ + + L + S ++T L
Sbjct: 1995 QSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHL 2033
Score = 41.2 bits (95), Expect = 0.005
Identities = 42/185 (22%), Positives = 84/185 (45%), Gaps = 14/185 (7%)
Query: 817 EEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTS 876
+++ EL+ QL L+KEK+ + +L + EA Q +E+ K+E K + R +
Sbjct: 18 QKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICE 77
Query: 877 SGSKDKPGKECADAASPALSLAELRTTCSENELAAEFTNAIRREKKLKARVQELVSALER 936
S K K S L + E + E +L + + E++LK EL + ++
Sbjct: 78 SLEKTK------QKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERS-QQ 130
Query: 937 LTKSSEIR----HQQSAEFVNDLKRANSNLVAAYEKAKKKHQNKL---KKLESQMMAMVE 989
+S+++ + F L + + YE K+K+ ++ K+LE+++ A+
Sbjct: 131 AAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQA 190
Query: 990 RHETQ 994
+ +Q
Sbjct: 191 KKASQ 195
Score = 33.5 bits (75), Expect = 1.0
Identities = 76/394 (19%), Positives = 158/394 (40%), Gaps = 48/394 (12%)
Query: 66 QLNMEESVAEIMNQLGADENGKISFQDFTRCRMQLVREIRKEEVDLSAKSDNSCTKKLRD 125
+++ E EI N ++ + + M+L ++ + + +N C K
Sbjct: 669 EMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKT--S 726
Query: 126 RIASWPTSSDNSLGALSAARESWEYDSGARDLQSPDVQSQSALQKLLEYGGSSL-----H 180
++ ++ L LS E + D +DL + +L+ LL+ +SL H
Sbjct: 727 QLTGQVEDLEHKLQLLS--NEIMDKDRCYQDLHA----EYESLRDLLKSKDASLVTNEDH 780
Query: 181 QQAALHKLLTQSPHIGNSVGGSYLELANTLHSAALASLKGDIVELNKRLQQTERERDLLE 240
Q++ L Q P + +S E + + L+ D N + Q D LE
Sbjct: 781 QRSLL--AFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRV--DSLE 836
Query: 241 KKLAKAQCEQSHLMREHEDVQERTTLRYEE--RITELH-SVIAELNKKIDRLQGTTIREE 297
L + S L ++ E++ + E + ++H S +AE +++I +LQ T +
Sbjct: 837 FSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQ 896
Query: 298 DEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLT 357
+ +E S L + E+ + ++ +Q + + + ++ D ELQ +
Sbjct: 897 NVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLL-------EDSLKELQLL-- 947
Query: 358 GLENVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGR--------- 408
E + +K+ S +S+ + R IE+LT + T++EI L +
Sbjct: 948 -SETLSLEKKEMSSIISLNK--REIEELTQEN-------GTLKEINASLNQEKMNLIQKS 997
Query: 409 DLYPNLAEERSRWEKELAGLREENESLTAMLCSK 442
+ + N +ER + EL+ ++ + + C +
Sbjct: 998 ESFANYIDEREKSISELSDQYKQEKLILLQRCEE 1031
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 84.3 bits (207), Expect = 5e-16
Identities = 175/856 (20%), Positives = 344/856 (40%), Gaps = 142/856 (16%)
Query: 214 ALASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERIT 273
A L+GD+ + + E ++ +E+KL K + E S L + +D Q +L+++++I
Sbjct: 1055 AKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVH-SLQFQKKIK 1113
Query: 274 ELHSVIAELNK----------KIDRLQGTTIREEDEYSELRSELS---QSQHEVNEDSRS 320
EL + I EL + KI++ + RE +E SE E S +Q E+N+ +
Sbjct: 1114 ELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREA 1173
Query: 321 ------MDQDQTSVSIPENQSTMVTADMDNCSDLNSE---LQRVLTGLENVVCGRKKSSC 371
D ++ ++ +T+ D+ ++L + LQRV LE ++KS
Sbjct: 1174 EFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLE-----KEKSEL 1228
Query: 372 SLSVAEVDRHIEQLTTASEHCDLAIKTVE-EIEGVLGRDLYPNLAEERSRWEKELAGLRE 430
+ + ++ +IE L+ + + + +TVE + + +D +K A L+
Sbjct: 1229 KMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQK--ARLQT 1286
Query: 431 ENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTS 490
+N L+ + KE +++ + A+ ++ + L+R++ E +T+ ++ A S
Sbjct: 1287 QNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEE-ETKAKNAMAHALQSSRHDCD 1345
Query: 491 TNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSV 550
R E AK + LSK SE V+
Sbjct: 1346 LLREQYEEEQE------------AKAELQRALSKANSE-----------------VAQWR 1376
Query: 551 AEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVETERLNSRIEHLKSQNDLLTIT 610
++ ++Q ++E + L +++E E TE NS+ L+ L
Sbjct: 1377 TKYETDAIQRTEELEEAKKKL--------AQRLQEAEENTETANSKCASLEKTKQRLQGE 1428
Query: 611 LEECKSNAERMSMLVGKYESNATAL-RLALQYSEQCIEAYELLLALAESEQSLILGQFRA 669
+E+ + ER + ++ ++ ++ E+ L A + +SL F+
Sbjct: 1429 VEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKM 1488
Query: 670 AGVGSSPGDQ---------SGDENITQMLKRAHDCRKTAENA--AKALLMKLDGSCGGAF 718
DQ + E I+ + ++ + K + A K L+ + A
Sbjct: 1489 RNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVAL 1548
Query: 719 AVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLK--NDRAAVKL- 775
S++ ES S S D + ++DE+ I+QLK + RAA L
Sbjct: 1549 EEVEGSLEHEESKILRVQLE-LSQVKSELDRKVIEKDEE-----IEQLKRNSQRAAEALQ 1602
Query: 776 TMLELE-SIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKK 834
++L+ E D L K GD +++ +L +MAE + L ++ + K
Sbjct: 1603 SVLDAEIRSRNDALRLKKKMEGDLNEMEI-------QLGHSNRQMAETQKHLRTVQGQLK 1655
Query: 835 ALELKL-----STREAQEQAYLVHIEH--LKSEVEEQK-----EQRMRSLSSTSSGSKDK 882
+L L S + +EQ +V + L E+EE K +R R LS
Sbjct: 1656 DSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSE-------- 1707
Query: 883 PGKECADAASPALSLAELRTTCSENELAAEFTNAIRREKKLKARVQELVSALERLTKSSE 942
+E DA+ ++ S+N T+ I +KKL+A + + + +E + S
Sbjct: 1708 --QELLDASD------RVQLLHSQN------TSLINTKKKLEADIAQCQAEVENSIQESR 1753
Query: 943 IRHQQSAEFVNDLK------RANSNLVAAYEKAKKKHQNKLKKLESQM----MAMVERHE 992
+++ + + D + + A E+ KK + +K L+ ++ ++ +
Sbjct: 1754 NAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGK 1813
Query: 993 TQVRMLKQRIALLEEE 1008
Q++ L+ R+ LE E
Sbjct: 1814 KQIQKLENRVRELENE 1829
Score = 83.6 bits (205), Expect = 9e-16
Identities = 169/875 (19%), Positives = 335/875 (38%), Gaps = 125/875 (14%)
Query: 215 LASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITE 274
+A++K D + L ++E R LE+K+ E++ L + + E + EER
Sbjct: 853 MATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENL-MDAEERCEG 911
Query: 275 LHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQ 334
L L K+ L EE+ SEL ++ + + + R +D + +++ E +
Sbjct: 912 LIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKE 971
Query: 335 STMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDL 394
+ N S+ +T LE + K SL A + ++ L + +
Sbjct: 972 KHATENKVKNLSE-------EMTALEENISKLTKEKKSLQEAH-QQTLDDLQVEEDKVNG 1023
Query: 395 AIK-------TVEEIEGVLGRDLYPNLAEERSRWEKE---------LAGLREENESLTAM 438
IK +++EG L ++ ER++ + E + L + + +
Sbjct: 1024 LIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEK 1083
Query: 439 LCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPS 498
L KE EL++ +A ++ + + +++++ELQ R++ ++ + + +
Sbjct: 1084 LKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDL 1143
Query: 499 TGELSTSSSSNDIPIAKIAERVKLSKTRSESSSS-----DRPVLGSEISSIGVSSSVAEH 553
EL S + + +++++K R + L E ++ + A+
Sbjct: 1144 ARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADS 1203
Query: 554 LAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVETERLNSRIEHL---KSQNDLLTIT 610
+A + N+Q + Q L E + E ++E + + S IE L KS + T
Sbjct: 1204 VAELGEQIDNLQRVKQKL--------EKEKSELKMEIDDMASNIEALSKSKSNIERTCRT 1255
Query: 611 LE----ECKSNAERMSMLVGKYESNATALRLALQYSE--QCIEAYELLLALAESEQSLIL 664
+E E K+ E+ + L+ ++ N RL Q E +E E L++ + +
Sbjct: 1256 VEDQFSEIKAKDEQQTQLI--HDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALT 1313
Query: 665 GQFRAAGVGSSPGDQSGDENITQMLKRAHDC-----RKTAENAAKALLMKLDGSCGGAFA 719
Q ++ + + HDC + E AKA L + A +
Sbjct: 1314 QQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQR-------ALS 1366
Query: 720 VAGCSVQPWES------------------------LSSNSHTSTTSSTASSCDTEFTKED 755
A V W + + +T T +S +S + +
Sbjct: 1367 KANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLE-----KT 1421
Query: 756 EQRLKDYIQQLKND--RAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENA-----VL 808
+QRL+ ++ L D R+ L+ + + D + + K + D + +LE A L
Sbjct: 1422 KQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSL 1481
Query: 809 MQELMAMKEEMAELKAQLYLLEKEKKALELKLS---TREAQEQAYLVHIEHLKSEVEEQK 865
EL M+ E+ QL L +E K L+ ++S + A+ L E K VE++K
Sbjct: 1482 STELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEK 1541
Query: 866 EQRMRSLSSTSSGSKDKPGKECADAASPALSLAELRTTCSENELAAEFTNAIRREKKLKA 925
+L + + K + +L + ++EL + ++LK
Sbjct: 1542 SDLQVALEEVEGSLEHEESK---------ILRVQLELSQVKSELDRKVIEKDEEIEQLKR 1592
Query: 926 RVQELVSALERLTKSSEIRHQQSA-----EFVNDLKRANSNL------VAAYEKAKKKHQ 974
Q AL+ + +EIR + A + DL L +A +K + Q
Sbjct: 1593 NSQRAAEALQSVL-DAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQ 1651
Query: 975 NKLKKLESQMMAMVERHETQVRMLKQRIALLEEEN 1009
+LK + + + +E LK+++A++E N
Sbjct: 1652 GQLKDSQLHLDDALRSNED----LKEQLAIVERRN 1682
Score = 82.0 bits (201), Expect = 3e-15
Identities = 175/838 (20%), Positives = 334/838 (39%), Gaps = 96/838 (11%)
Query: 216 ASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQ-------SHLMREHEDVQE--RTTL 266
+SLK DI +L L + E+E+ E K+ E S L +E + +QE + TL
Sbjct: 952 SSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTL 1011
Query: 267 R----YEERITELHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMD 322
E+++ L + A+L ++ D L+G+ +E+ +LR++L +++ ++ D +
Sbjct: 1012 DDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEK----KLRADLERAKRKLEGD---LK 1064
Query: 323 QDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHI 382
Q S+ EN + + S+LQ + E V + E+ I
Sbjct: 1065 MSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDD-EQV----HSLQFQKKIKELQARI 1119
Query: 383 EQLTTASEHCDLAIKTVEEIEGVLGRDLYPNLAEERSRWEKELAGLREENESLTAMLCSK 442
E+L EEIE L + ++RS +EL + E E + ++
Sbjct: 1120 EELE-------------EEIEA--EHTLRAKIEKQRSDLARELEEISERLEEASGATSAQ 1164
Query: 443 EEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGEL 502
E + +A +R + + + L+ QA + G + + +L
Sbjct: 1165 IEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQ---KL 1221
Query: 503 STSSSSNDIPIAKIAERVK-LSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDC 561
S + I +A ++ LSK++S + R V + S I L H L
Sbjct: 1222 EKEKSELKMEIDDMASNIEALSKSKSNIERTCRTV-EDQFSEIKAKDEQQTQLIHDLNMQ 1280
Query: 562 SNIQEIFQTLYSHGSAISESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKS-NAER 620
+ SH ES I + + L ++E LK Q + EE K+ NA
Sbjct: 1281 KARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQME------EETKAKNAMA 1334
Query: 621 MSMLVGKYESNATALRLALQYSEQCIEAYELLLAL--AESEQSLILGQFRAAGVGSSPGD 678
++ +++ + L QY E+ EL AL A SE + ++ + +
Sbjct: 1335 HALQSSRHDCDL----LREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEEL 1390
Query: 679 QSGDENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTS 738
+ + + Q L+ A + +TA N+ A L K G V+ SHT+
Sbjct: 1391 EEAKKKLAQRLQEAEENTETA-NSKCASLEKTKQRLQG-------EVEDLMRDLERSHTA 1442
Query: 739 TTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDPL----SYDVKP 794
+T F K L ++ Q+L +A ++ E S+ + +Y+ +
Sbjct: 1443 --CATLDKKQRNFDKV----LAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYE-EV 1495
Query: 795 RGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHI 854
+ L EN L +E+ + E++AE L EK KK +E + S + + +
Sbjct: 1496 VDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSL 1555
Query: 855 EHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKECADAASPALSLAELRTTCSENELAAEF- 913
EH EE K R++ S D+ E + ++ ++ L AE
Sbjct: 1556 EH-----EESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIR 1610
Query: 914 --TNAIRREKKLKARVQEL----------VSALERLTKSSEIRHQQSAEFVNDLKRANSN 961
+A+R +KK++ + E+ ++ ++ ++ + + + S ++D R+N +
Sbjct: 1611 SRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNED 1670
Query: 962 LVAAYEKAKKKHQNKLKKLESQMMAMVERHETQVRMLKQRIALLEEENSRPHTNETSL 1019
L ++++ L++LE +A+ + T+ R+ +Q + + H+ TSL
Sbjct: 1671 LKEQLAIVERRNGLLLEELEEMKVALEQTERTR-RLSEQELLDASDRVQLLHSQNTSL 1727
Score = 49.7 bits (117), Expect = 1e-05
Identities = 105/607 (17%), Positives = 220/607 (36%), Gaps = 69/607 (11%)
Query: 418 RSRWEKELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSV 477
R E+++ L +E L + S+ E L + + + + L +V+EL RL+
Sbjct: 874 RKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSKILLEAKVKELTERLEEE 933
Query: 478 QATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVL 537
+ L + R + L ++ + K+ + ++ + ++ S + L
Sbjct: 934 EEMN----SELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTAL 989
Query: 538 GSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVETERLNSRI 597
IS + ++ ++QE Q + + +VE +++N I
Sbjct: 990 EENISKL-------------TKEKKSLQEAHQ-----------QTLDDLQVEEDKVNGLI 1025
Query: 598 E---HLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYELLLA 654
+ L+ Q D L +LE+ K + K E + + ++ E + E L
Sbjct: 1026 KINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLK 1085
Query: 655 LAESEQSLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRK--TAENAAKALLMKLDG 712
E E L Q +A + I ++ R + + AE+ +A + K
Sbjct: 1086 KKEFE----LSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRS 1141
Query: 713 SCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAA 772
L S +S A+S E K+ E + + L+
Sbjct: 1142 DLA-------------RELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQ 1188
Query: 773 VKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKE 832
+ T L D ++ + + QR+ + L +E +K E+ ++ + + L K
Sbjct: 1189 HEATAATLRKKQADSVAELGEQIDNLQRVKQK---LEKEKSELKMEIDDMASNIEALSKS 1245
Query: 833 KKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGK-----EC 887
K +E T E Q +K++ +EQ+ Q + L+ + + + G+ E
Sbjct: 1246 KSNIERTCRTVEDQ-------FSEIKAK-DEQQTQLIHDLNMQKARLQTQNGELSHRVEE 1297
Query: 888 ADAASPALSLAELRTTCSENELAAEFTNAIRREKKLKARVQELVSALERLTKSSEIRHQQ 947
++ L+ ++ T EL + + + + +Q + L + E +
Sbjct: 1298 KESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEA 1357
Query: 948 SAEFVNDLKRANSNLV---AAYEKAKKKHQNKLKKLESQMMAMVERHETQVRMLKQRIAL 1004
AE L +ANS + YE + +L++ + ++ ++ E + A
Sbjct: 1358 KAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCAS 1417
Query: 1005 LEEENSR 1011
LE+ R
Sbjct: 1418 LEKTKQR 1424
Score = 42.7 bits (99), Expect = 0.002
Identities = 66/297 (22%), Positives = 119/297 (40%), Gaps = 71/297 (23%)
Query: 788 LSYDVKPRGDSQRLDLENAVLMQELMAMKEEMA-------ELKAQLYLLEKEKKALELKL 840
L + +KP S + E A + ++ KEE+A EL+ ++ L +EK L+L++
Sbjct: 836 LFFKIKPLLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQV 895
Query: 841 STR-----EAQEQA---------YLVHIEHLKSEVEEQKEQ------RMRSLSSTSSGSK 880
+ +A+E+ ++ L +EE++E + R+L S K
Sbjct: 896 QSETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLK 955
Query: 881 ----------DKPGKECADAASPALSLAELRTTCSEN--------------------ELA 910
K KE + +L+E T EN +L
Sbjct: 956 RDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQ 1015
Query: 911 AE---FTNAIRREKKLKARVQELVSALERLTKSSEIRHQQSAEFVNDLKRANSNLVAAYE 967
E I+ KL+ + +L +LE+ K + + DLK + +++ E
Sbjct: 1016 VEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIM-DLE 1074
Query: 968 KAKKKHQNKLKKLE---SQMMAMVE-------RHETQVRMLKQRIALLEEENSRPHT 1014
K++ + KLKK E SQ+ A ++ + + +++ L+ RI LEEE HT
Sbjct: 1075 NDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHT 1131
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 83.6 bits (205), Expect = 9e-16
Identities = 172/869 (19%), Positives = 347/869 (39%), Gaps = 119/869 (13%)
Query: 215 LASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITE 274
+A++K + + L ++E +R LE+KL E++ L + + + L EER +
Sbjct: 850 MATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQ-AESENLLDAEERCDQ 908
Query: 275 LHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQ 334
L +L KI + T R EDE E+ +EL+ + ++ ++ + +D I + +
Sbjct: 909 LIKAKFQLEAKIKEV---TERAEDE-EEINAELTAKKRKLEDECSELKKD-----IDDLE 959
Query: 335 STMVTADMDNCSDLN--SELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTASEHC 392
T+ + + + N L L+GL+ + + +L A + ++ L +
Sbjct: 960 LTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAH-QQALDDLQAEEDKV 1018
Query: 393 DLAIKT-------VEEIEGVLGRDLYPNLAEERSRWEKE---------LAGLREENESLT 436
+ KT VE++E L ++ + ER++ + E + L + + L
Sbjct: 1019 NSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLD 1078
Query: 437 AMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPIN 496
L K+ E + ++ + + + +++++ELQ R++ ++ + T + +
Sbjct: 1079 ERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRS 1138
Query: 497 PSTGELSTSSSSNDIPIAKIAERVKLSKTRSES-----SSSDRPVLGSEISSIGVSSSVA 551
EL S + + +++L+K R + L E + A
Sbjct: 1139 DYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHA 1198
Query: 552 EHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVETERLNSRIEHL-KSQNDLLTIT 610
+ +A + N+Q + Q L E + EF++E + L+S +E + KS+ +L I
Sbjct: 1199 DSVAELGEQIDNLQRVKQKL--------EKEKSEFKLEIDDLSSSMESVSKSKANLEKI- 1249
Query: 611 LEECKSNAERMSMLVGKYESNATAL-RLALQYSEQCIEAYELLLALAESEQSLILGQFRA 669
C++ +++S GK E +L L Q S EA EL L E E I+ Q
Sbjct: 1250 ---CRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKES--IVSQL-- 1302
Query: 670 AGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAKALLMKLDGSCG-------------- 715
S Q+ + T+ LKR + A+NA L C
Sbjct: 1303 -----SRSKQAFTQQ-TEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKA 1356
Query: 716 ---GAFAVAGCSVQPW-------------------ESLSSNSHTSTTSSTASSCDTEFTK 753
A + A V W + L+ S A + +
Sbjct: 1357 ELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLE 1416
Query: 754 EDEQRLKDYIQQLKND--RAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAV---- 807
+ +QRL+ ++ L D RA L+ + + D + + K + + + +LE ++
Sbjct: 1417 KTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESR 1476
Query: 808 -LMQELMAMKEEMAELKAQLYLLEKEKKALELKLS--TREAQEQAYLVH-IEHLKSEVEE 863
L EL +K E QL +++E K LE +++ T + E +H +E + ++E
Sbjct: 1477 SLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIEL 1536
Query: 864 QKEQRMRSLSSTSSGSKDKPGKECADAASPALSLAELRTTCSENELAAEFTNAIRREKKL 923
+K +L + + + K L L ++++ + ++A + + ++
Sbjct: 1537 EKADIQLALEEAEAALEHEEAK----ILRIQLELTQVKSEI-DRKIAEKDEEIEQLKRNY 1591
Query: 924 KARVQELVSALERLTKSSEIRHQQSAEFVNDLKRANSNLVAAYEKAKK--KH----QNKL 977
+ V+ + SAL+ +S + + DL L A +A + KH Q +L
Sbjct: 1592 QRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQL 1651
Query: 978 KKLESQMMAMVERHETQVRMLKQRIALLE 1006
K + + + E LK+++A++E
Sbjct: 1652 KDTQLHLDDALRGQED----LKEQLAIVE 1676
Score = 46.6 bits (109), Expect = 1e-04
Identities = 63/293 (21%), Positives = 126/293 (43%), Gaps = 29/293 (9%)
Query: 215 LASLKGDIVELNKRLQQTERERDLLEKKLAKAQC--EQSHLMREHEDVQE-RTTLRYEER 271
+A L I E K + + E+ R +E + A Q E++ EHE+ + R L +
Sbjct: 1510 IADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQV 1569
Query: 272 ITELHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIP 331
+E+ IAE +++I++L+ R + +S++E + M+ D + I
Sbjct: 1570 KSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQ 1629
Query: 332 ENQSTMVTAD-MDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAE-----VDRHIEQL 385
+ + A+ + + + +L+ L++ + G++ L++ E + +E+L
Sbjct: 1630 LSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEEL 1689
Query: 386 TTASEHCDLAIKTVEEI-----EGV-LGRDLYPNLAEERSRWEKELAGLREENESLTAML 439
E + A K E+ E V L +L + + E +L L+ E E +
Sbjct: 1690 RATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDA 1749
Query: 440 CSKEEELNR--TKATMNA--IREERD----------RLRRRVRELQTRLQSVQ 478
+ EE+ + T A M A +++E+D L + V++LQ RL +
Sbjct: 1750 RNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAE 1802
Score = 46.2 bits (108), Expect = 2e-04
Identities = 51/215 (23%), Positives = 100/215 (46%), Gaps = 26/215 (12%)
Query: 788 LSYDVKPRGDSQRLDLENAVLMQELMAMKEEMA-------ELKAQLYLLEKEKKALELKL 840
L + +KP S + E A + +E K+E+A EL+ +L L +EK L+L++
Sbjct: 833 LFFKIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQV 892
Query: 841 STR-----EAQEQAYLV-----HIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKECADA 890
+A+E+ + +E EV E+ E +++ + K K EC++
Sbjct: 893 QAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDE-EEINAELTAKKRKLEDECSEL 951
Query: 891 ASPALSLAELRTTCSENELAAEFT-NAIRREKKLKARVQELVSALERLTKSSEIRHQQSA 949
+ +L T ++ E T N ++ + + + E ++ L R K+ + HQQ+
Sbjct: 952 KK---DIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQA- 1007
Query: 950 EFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQM 984
++DL +A + V + K K K + +++ LES +
Sbjct: 1008 --LDDL-QAEEDKVNSLNKTKSKLEQQVEDLESSL 1039
Score = 41.2 bits (95), Expect = 0.005
Identities = 92/513 (17%), Positives = 203/513 (39%), Gaps = 52/513 (10%)
Query: 65 RQLNMEESVAEIMNQLGADE------NGKISFQDFTRCRMQLVREIRKEEVDLSAKSDNS 118
R +EE+ ++ +L E N K + + T+ R+Q E +V+ + +
Sbjct: 1383 RTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAA 1442
Query: 119 CTKKLRDR---IASWPTSSDNSLGALSAA-RESWE-----------YDSGARDLQSPDVQ 163
KK R+ +A W T + S L A+ +ES Y+ L++ +
Sbjct: 1443 LDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRE 1502
Query: 164 SQSALQKLLEYGGSSLHQQAALHKLLTQSPHIGNSVGGSYLELANTLHSAALASLKGDIV 223
+++ Q++ + +H+L I + + ++LA AAL + I+
Sbjct: 1503 NKNLEQEIADLTEQIAENGKTIHELEKSRKQI--ELEKADIQLALEEAEAALEHEEAKIL 1560
Query: 224 ELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITELHSVIAELN 283
+ L Q + E +++K+A+ E L R ++ E + + + I L
Sbjct: 1561 RIQLELTQVKSE---IDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAI-RLK 1616
Query: 284 KKID--------RLQGTTIREEDEYSELRS---ELSQSQHEVNEDSRSMDQDQTSVSIPE 332
KK++ +L + + LRS +L +Q +++ R + + ++I E
Sbjct: 1617 KKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVE 1676
Query: 333 NQSTMVTADMDNCSDLNSELQR--------VLTGLENV-VCGRKKSSCSLSVAEVDRHIE 383
++ ++ A+++ + +R +L E V + + +S + +++ +
Sbjct: 1677 RRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLM 1736
Query: 384 QLTTASEHCDLAIKTVEEIEGVLGRDLYPNLAEERSRWEKELAGLREENESLTAMLCSKE 443
QL + E + EE D +AEE + + A L ++L + +
Sbjct: 1737 QLQSEVEDASRDARNAEEKAKKAITDA-AMMAEELKKEQDTSAHLERMKKNLEQTVKDLQ 1795
Query: 444 EELNRTKA-TMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGEL 502
L+ + + +++ +L R+REL+ L+ Q S L R + T +
Sbjct: 1796 HRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQ- 1854
Query: 503 STSSSSNDIPIAKIAER--VKLSKTRSESSSSD 533
S N + + + ++ VK+ + ++ +D
Sbjct: 1855 SEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEAD 1887
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 82.8 bits (203), Expect = 2e-15
Identities = 194/926 (20%), Positives = 376/926 (40%), Gaps = 137/926 (14%)
Query: 149 EYDSGARDLQSPDVQSQSALQKLLEYGGSSLHQQAALHKLLTQSPHIGNSVGGSYL-ELA 207
E D+ AR L + + ++AL++ Q+AA K + Q + ELA
Sbjct: 825 ERDAAARQLAQAEQEGKTALEQ----------QKAAHEKEVNQLREKWEKERSWHQQELA 874
Query: 208 NTLHSAALASLKGDIVELNKRL--QQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTT 265
AL SL+ + +EL RL QQTE E +++ + Q E + + E +ER +
Sbjct: 875 K-----ALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVS 929
Query: 266 LRYEERITELHSVIAELNKKIDRLQGTT----IREEDEYSELRSELSQSQHEVNEDSRSM 321
L E + + +A+ +++++RL+ ++E++ L+++L ++Q E+ E +R
Sbjct: 930 LL--ETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQH 987
Query: 322 DQDQTSVSIPENQSTMVTADMD---NCSDLNSEL-----QRVLTGLENVVCGRKKSSCSL 373
D ++ E S+++ MD DL S+L + L E R+ +
Sbjct: 988 RDDLAALQ--EESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNR 1045
Query: 374 SVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYP--NLAEERSRWEKELAG---- 427
E++R LT + + + ++E + + ++L +E +KEL+
Sbjct: 1046 IQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMEL 1105
Query: 428 LREENESLTAMLCSKE----EELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPS 483
LR+E + A ++E EEL + T +R + +LQ RL+S + S
Sbjct: 1106 LRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTE----S 1161
Query: 484 SPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEISS 543
L + +P N + + +S + + A + + S S V G E
Sbjct: 1162 QLEALAAEQQPGNQAQAQAQLASLYSALQQA-LGSVCESRPELSGGGDSAPSVWGLEPDQ 1220
Query: 544 IGVSS--------------SVAEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVE 589
G S +VA L QD Q+ L + E ++ + E E
Sbjct: 1221 NGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEE-RLTDTEAE 1279
Query: 590 TERLNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAY 649
++++ ++ L+ Q N E S GK S + L +E +
Sbjct: 1280 KSQVHTELQDLQRQ----------LSQNQEEKSKWEGKQNSLESEL----------MELH 1319
Query: 650 ELLLALAESEQSLILGQFRAAGVGSSPGDQSGDENITQMLK--RAHDCRKTAENAAKALL 707
E + +L + L + A G Q+ EN+T ++ +A A+ +A +L
Sbjct: 1320 ETMASLQSRLRRAELQRMEAQGERELL--QAAKENLTAQVEHLQAAVVEARAQASAAGIL 1377
Query: 708 ----------MKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDE- 756
+KL + ++Q L + + A T +E+E
Sbjct: 1378 EEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEV 1437
Query: 757 QRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAMK 816
+ L+ IQ+L+ R E++ ++ LS D+K R +Q +DL+ + QEL +
Sbjct: 1438 ETLRGQIQELEKQR--------EMQKAALELLSLDLKKR--NQEVDLQQEQI-QELEKCR 1486
Query: 817 EEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVH--IEHLKSEVEEQKEQRMRSLSS 874
+ L + + E+E+K + RE ++ +EH E+E+ K+Q + S
Sbjct: 1487 SVLEHLP--MAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEK-KDQMIESQRG 1543
Query: 875 TSSGSKDKPGKECADAASPALSLAELRTTCSENELAAEFTNAIRREKKLKARVQELVSAL 934
+ D ++L L EN E + +E + + Q + AL
Sbjct: 1544 -----------QVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRV--AL 1590
Query: 935 ERLTKSSEIRHQQ---SAEFVNDLKRANSNLVAAYE------KAKKKHQNKLKKLESQMM 985
LT E R Q+ + ++DL+ ++ L + K++++ +L++ + +
Sbjct: 1591 THLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLT 1650
Query: 986 AMVERHETQVRMLKQRIALLEEENSR 1011
+ER + ++ + K+RI +LE++ +R
Sbjct: 1651 QDLERRDQELMLQKERIQVLEDQRTR 1676
Score = 77.8 bits (190), Expect = 5e-14
Identities = 156/810 (19%), Positives = 322/810 (39%), Gaps = 113/810 (13%)
Query: 225 LNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQE-RTTLRYEERITE-----LHSV 278
L +RLQ+ ERD L + Q E L +E E +Q+ R LR + + E L V
Sbjct: 433 LRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRV 492
Query: 279 IAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMV 338
EL + D QG ++E++ EL + + + + E ++ Q+ E+ S ++
Sbjct: 493 NVELQLQGDSAQG---QKEEQQEELHLAVRERER-LQEMLMGLEAKQS-----ESLSELI 543
Query: 339 TA-DMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDLAIK 397
T + S L EL R ++++ + ++A ++ I +L+++ +
Sbjct: 544 TLREALESSHLEGELLR-----------QEQTEVTAALARAEQSIAELSSSENTLKTEVA 592
Query: 398 TVEEIEGVLGRDLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKATMNAIR 457
+ L L LA ++ ++L L EEN+S+ + + + E+ N + +
Sbjct: 593 DLRAAAVKLSA-LNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAE 651
Query: 458 EERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIA 517
+ R+ L + L+ +LQ + G L +LS S + ++
Sbjct: 652 KRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLE 711
Query: 518 ERVKLSKTRSE---SSSSDRPVLGSEISSIGVSSSVAEH----LAHSLQDCSNIQEIFQT 570
+ + +K + E + ++ L E +++ V E LA LQ S+ +E+ ++
Sbjct: 712 QLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLES 771
Query: 571 LYSHGSAISESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKYES 630
E ++ NS IE K Q ++ T+ + K ++ G+
Sbjct: 772 SL---------------FEAQQQNSVIEVTKGQLEVQIQTVTQAKE------VIQGEVRC 810
Query: 631 NATALRLALQYSEQCIEAYELLLALAESEQSLILGQFRAAGVGSSPGDQSGDENITQMLK 690
L +EQ +A LA AE E L Q +AA ++ + Q+ +
Sbjct: 811 LKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAH----------EKEVNQLRE 860
Query: 691 RAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTE 750
+ R + L L+ E++ + T + ++ C +
Sbjct: 861 KWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQ 920
Query: 751 FTKEDEQ------------RLKDYIQQLKNDRAAVKLTMLELESI------HIDPLSYDV 792
E E+ L D QQL+ R +K+ L+ + + ++
Sbjct: 921 LETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQREL 980
Query: 793 KPRGDSQRLDL-----ENAVLMQELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQE 847
K R DL E++ L+Q+ M +++++ +LK+QL + ++ +E ++ + +
Sbjct: 981 KEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRET 1040
Query: 848 QAYLVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKECADAASPALSLAELRTTCSEN 907
Q Y ++ E+E +K SL +K + + ++ EL +
Sbjct: 1041 QEY----NRIQKELEREKASLTLSL-------MEKEQRLLVLQEADSIRQQEL------S 1083
Query: 908 ELAAEFTNAIRREKKLKARVQELVSALER-----LTKSSEIRHQQSAEFVNDLKRANSNL 962
L + A +K+L A+++ L ++ L + +++ + A + + ++ ++L
Sbjct: 1084 ALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITE-QQLRASL 1142
Query: 963 VAAYEKAKKKHQNKLKKLESQMMAMVERHE 992
A KA + Q +L+ ESQ+ A+ +
Sbjct: 1143 WAQEAKAAQL-QLRLRSTESQLEALAAEQQ 1171
Score = 75.1 bits (183), Expect = 3e-13
Identities = 224/1120 (20%), Positives = 426/1120 (38%), Gaps = 169/1120 (15%)
Query: 34 TGEEERMRRLFQTCDGDGDGYISRNDLLMVCR-----QLNMEESVA--------EIMNQL 80
TGE + + G+ D +LL R QL + E A E+ Q
Sbjct: 441 TGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQG 500
Query: 81 GADENGKISFQDFTRCRMQLVREIRKEEVDLSAKSDNSCTKKLRDRIASWPTSSDNSL-- 138
+ + K Q+ ++ +++ + L AK S ++ + R A + + L
Sbjct: 501 DSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLR 560
Query: 139 -------GALSAARESW-EYDSGARDLQSPDVQSQSALQKLLEYGGSSLHQQAALHKLLT 190
AL+ A +S E S L++ ++A KL + + L++ L
Sbjct: 561 QEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLL 620
Query: 191 QSPHIGNSVGGSYLELANTLHSAALASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQ 250
Q SV S +E A +A L+ D+ E KR + + LE +L KA+
Sbjct: 621 QLEEENQSVC-SRMEAAEQARNA----LQVDLAEAEKRREALWEKNTHLEAQLQKAEEAG 675
Query: 251 SHLMREHEDVQE----------RTTLRYEERITELHSVIAELNKKIDRLQGTTIREEDEY 300
+ L + D+QE + + E T+L + E K+ + + ++E++
Sbjct: 676 AELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEA-KRQEEVLARAVQEKEAL 734
Query: 301 SELRSELSQSQHEVNEDSRSMDQDQTSVSIPEN--QSTMVTADMDNC------SDLNSEL 352
++ L V D + + + +S + +S++ A N L ++
Sbjct: 735 VREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQI 794
Query: 353 QRVLTGLE----NVVCGRKKSSCSLSVAEVDRH--IEQLTTASEHCDLAIKTVEEIEGVL 406
Q V E V C + + S AE +R QL A + A++ +
Sbjct: 795 QTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKE 854
Query: 407 GRDLYPNLAEERSRWEKELA---------------GLREENESLTAMLCSKEEELNRTKA 451
L +ERS ++ELA L+E+ + A+ +EEE RT+A
Sbjct: 855 VNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEE--RTQA 912
Query: 452 TMNAIREERDRLRRRVRELQTRLQSVQATGPSSP--GRLTSTNR----PINPSTGELST- 504
+ + + + RV L+T LQ+ + +S RL + +TG L T
Sbjct: 913 ESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQ 972
Query: 505 -SSSSNDIPIAKIAERVKLSKTRSESSS--SDRPVLGSEISSIG------------VSSS 549
+ ++ A R L+ + ESSS D+ L ++ + V
Sbjct: 973 LQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQE 1032
Query: 550 VAEHLAHSLQDCSNIQEIFQ-----------------TLYSHGSAISESKIREFEVETER 592
V E L + Q+ + IQ+ + + +I + ++ + +
Sbjct: 1033 VQEKLRET-QEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQE 1091
Query: 593 LNSRIEHLKSQNDLLTITLEECKSN--AERMSMLVGKYESNATALRLALQYSEQCIEAYE 650
+ L +Q +LL ++E +++ A+ +L S+ T +L Q +A +
Sbjct: 1092 AQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQ 1151
Query: 651 LLLALAESEQSLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAKALLMKL 710
L L L +E Q A PG+Q+ L + + A + +L
Sbjct: 1152 LQLRLRSTE-----SQLEALAAEQQPGNQA---QAQAQLASLYSALQQALGSVCESRPEL 1203
Query: 711 DGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSC------------DTEFTKEDEQR 758
G GG A + ++P ++ + + TA S D T++
Sbjct: 1204 SG--GGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDV 1261
Query: 759 LKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDV-----KPRGDSQRLDLENAVLMQELM 813
L+D +Q+L+ +LT E E + D+ + + + + + + L ELM
Sbjct: 1262 LRDQVQKLEE-----RLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELM 1316
Query: 814 AMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRM---- 869
+ E MA L+++L E ++ + + +A ++ +EHL++ V E + Q
Sbjct: 1317 ELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGI 1376
Query: 870 --RSLSSTSSGSKDK-----PGKECADAASPALSLAELRTTCSENELAAEFTNAIRREKK 922
L + S K K +E A A L + + LA RE++
Sbjct: 1377 LEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEE 1436
Query: 923 ---LKARVQEL-------VSALERLTKSSEIRHQQ---SAEFVNDLKRANSNLVAAYEKA 969
L+ ++QEL +ALE L+ + R+Q+ E + +L++ S ++ A
Sbjct: 1437 VETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRS-VLEHLPMA 1495
Query: 970 KKKHQNKLKKLESQMMAMVERHETQVRMLKQRIALLEEEN 1009
++ + KL Q+ + + ETQ +L+ ++ LE+++
Sbjct: 1496 VQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKD 1535
Score = 69.3 bits (168), Expect = 2e-11
Identities = 158/836 (18%), Positives = 313/836 (37%), Gaps = 133/836 (15%)
Query: 274 ELHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPEN 333
+LH + + + D L+ + E+ ++ +E SQ E+ + R + Q+Q S E
Sbjct: 1247 KLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEG 1306
Query: 334 QSTMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHI-----EQLTTA 388
+ + L SEL + + ++ +++ A+ +R + E LT
Sbjct: 1307 KQ----------NSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQ 1356
Query: 389 SEHCDLAI---KTVEEIEGVLGRDLYP-----NLAEERSRWEKELA-GLREENESLTAML 439
EH A+ + G+L DL L E E+E A L+E+ E A
Sbjct: 1357 VEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQG 1416
Query: 440 CSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPST 499
+ +E L T+ EE + LR +++EL+ + + +A L N+ ++
Sbjct: 1417 KALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQ 1476
Query: 500 GELSTSSSSNDI----PIAKIAERVKLSKTRSE------SSSSDRPVLGSEISSIGVSSS 549
++ + P+A KL+ R + + R VL ++ +
Sbjct: 1477 EQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQ 1536
Query: 550 VAEHLAHSLQDCSNIQEIFQTLY------SHGSAISESKIREFEVETERLNSRIEHLKSQ 603
+ E +QD + L H + I+E E + E + HL
Sbjct: 1537 MIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHL--- 1593
Query: 604 NDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAY------------EL 651
T+ LEE + S + ES++T L LQ +Q +++ L
Sbjct: 1594 ----TLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHL 1649
Query: 652 LLALAESEQSLILGQFRAAGVGSSPGDQSG--DENITQMLKRAHDCRKTAENAAKALLMK 709
L +Q L+L + R + Q+ +E++ Q+ + + + + +
Sbjct: 1650 TQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQER 1709
Query: 710 LDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQ---- 765
+ G + A G SL C E E Q LKD ++Q
Sbjct: 1710 AEEGKGPSKAQRG-------SLEHMKLILRDKEKEVECQQEHIHE-LQELKDQLEQQLQG 1761
Query: 766 --LKNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLEN---------AVLMQELMA 814
K ++ L+ E E + + + + +G+ + L++ A QEL A
Sbjct: 1762 LHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEA 1821
Query: 815 MKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSS 874
+++E + + Q E++ E + + A EQA++ ++ E+++ KEQ R
Sbjct: 1822 LQQEQQQAQGQ------EERVKEKADALQGALEQAHMT-LKERHGELQDHKEQARRLEEE 1874
Query: 875 TS------SGSKDKPGKECADAASPALSLAELRTTCSE---------------------- 906
+ ++ G A++ +L L+ C+E
Sbjct: 1875 LAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAV 1934
Query: 907 --------NELAAEFTNAIRREKKLKARVQELVSALERLTKSSEIRHQ---QSAEFVNDL 955
L AE ++ +E+ +AR + L AL + + + + Q + AE L
Sbjct: 1935 LKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSL 1994
Query: 956 KRANSNLVAAYEKAK---KKHQNKLKKLESQMMAMVERHETQVRMLKQRIALLEEE 1008
+ + + L A+ + + ++ + L+ E ++ R++ V+ L+Q +A +EE
Sbjct: 1995 EASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEE 2050
Score = 62.8 bits (151), Expect = 2e-09
Identities = 172/905 (19%), Positives = 326/905 (36%), Gaps = 169/905 (18%)
Query: 241 KKLAKAQCEQSHLMREHEDVQERTTLRYEERITELHSVIAELNKK-------IDRLQGTT 293
++L K E+S + + + + ++R+TEL +++ + K+ I L+ T
Sbjct: 254 QELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETV 313
Query: 294 IREEDEYSELRSELSQSQHEVNEDSRSMDQ---DQTSVSIPENQSTMVTADMDNCSDLNS 350
E ++EL + E+ S+ Q D T V + E + + +N +L+S
Sbjct: 314 EILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDS 373
Query: 351 EL---------QRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVE- 400
+ + LT + +V+ R+++ L +QL E +L + +
Sbjct: 374 SIFSQFDYQDADKALTLVRSVLTRRRQAVQDLR--------QQLAGCQEAVNLLQQQHDQ 425
Query: 401 -EIEGVLGRDLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEEL-----NRTKATMN 454
E EG R L ER + L+ E +SL SKE EL + +
Sbjct: 426 WEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSL-----SKERELLQKAREELRQQLE 480
Query: 455 AIREERDRLRR-------------------------RVRE---LQTRLQSVQATGPSSPG 486
+ +E RLRR VRE LQ L ++A S
Sbjct: 481 VLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLS 540
Query: 487 RLTSTNRPI------------------------NPSTGELSTSSSSNDIPIAKI-AERVK 521
L + + S ELS+S ++ +A + A VK
Sbjct: 541 ELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVK 600
Query: 522 LSKTRSESSSSDRPVLGSEI-------SSIGVSSSVAEHLAHSLQ-DCSNIQEIFQTLYS 573
LS +E+ + D+ L ++ S+ AE ++LQ D + ++ + L+
Sbjct: 601 LS-ALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWE 659
Query: 574 HGSAIS-------------ESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAER 620
+ + ++ +R+ + E E + ++ + Q + T LE+ A+R
Sbjct: 660 KNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKR 719
Query: 621 MSMLVGKYESNATAL---RLALQYSEQCIE-----AYELLLALAESEQSLILGQFRAAGV 672
++ + AL + AL+ Q +E E L L+ +++ L F A
Sbjct: 720 QEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQ 779
Query: 673 GSSPGDQSGDENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQPWESLS 732
S G + ++ ++ + + L ++LD A + +
Sbjct: 780 NSVIEVTKGQLEV--QIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAE 837
Query: 733 SNSHTSTTSSTA------SSCDTEFTKE---DEQRLKDYIQQLKNDRAAVKLTM----LE 779
T+ A + ++ KE +Q L ++ L+ ++ +++ + E
Sbjct: 838 QEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTE 897
Query: 780 LESIHIDPLSYDVKPRGDSQRLDL----ENAVLMQELMAMKEEMAELKAQLYLLEKEKKA 835
+E+I + ++ L E L++ L+ ++E+A+ QL L ++ K
Sbjct: 898 MEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKV 957
Query: 836 LELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSSG-----------SKDKPG 884
+LK Q L + E Q + +L SS +D
Sbjct: 958 QKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKS 1017
Query: 885 KECADAASPALSLAELRTTCSENELAAEFTNAIRREK-KLKARVQELVSALERLTKSSEI 943
+ A S L E++ E + + REK L + E L L ++ I
Sbjct: 1018 QLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSI 1077
Query: 944 RHQQSAEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQM-MAMVERHETQVRMLKQRI 1002
R Q+ + D++ A Q + K+L +QM + E E + L Q
Sbjct: 1078 RQQELSALRQDMQEA---------------QGEQKELSAQMELLRQEVKEKEADFLAQEA 1122
Query: 1003 ALLEE 1007
LLEE
Sbjct: 1123 QLLEE 1127
Score = 59.3 bits (142), Expect = 2e-08
Identities = 194/952 (20%), Positives = 349/952 (36%), Gaps = 128/952 (13%)
Query: 154 ARDLQSPDVQSQ-SALQKLLEYGGSSLHQQAALHK---LLTQSPHIGNSVGGSYLELANT 209
A L++ +V+S+ Q L E G + Q AL + LLTQ+ LA
Sbjct: 1387 ALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQT-------------LAE- 1432
Query: 210 LHSAALASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYE 269
+ +L+G I EL K+ + + +LL L K E + E +QE R
Sbjct: 1433 -REEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVD---LQQEQIQELEKCR-- 1486
Query: 270 ERITELHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVS 329
+ L + E +K+ +Q IRE ++ E + + + Q E M + Q
Sbjct: 1487 SVLEHLPMAVQEREQKLT-VQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRG-Q 1544
Query: 330 IPENQSTMVTADMDNCSDLNSE--------LQRVLTGLENVVCGRKKSSCSLSVAEVDRH 381
+ + + +VT + C L E Q+++ LE ++ + +++ +
Sbjct: 1545 VQDLKKQLVTLE---CLALELEENHHKMECQQKLIKELEG-----QRETQRVALTHLTLD 1596
Query: 382 IEQLTTASEHCDLAIKTVEEIEGVLGRDLYPNLAEERSRWEKELAGLREENESLTAMLCS 441
+E+ + + I +E VL R+L E +S+ E ++ L+ + E LT L
Sbjct: 1597 LEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQRE-QIEELQRQKEHLTQDLER 1655
Query: 442 KEEELNRTKATMNAIREERDR---------------LRRRVRELQTRLQSVQATGPSSPG 486
+++EL K + + ++R R LR R REL T+ Q +Q G
Sbjct: 1656 RDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKG 1715
Query: 487 RLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGV 546
+ + L + I E +L + +G +
Sbjct: 1716 PSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQ 1775
Query: 547 SSSVAEHLAHSLQDCSNIQEI-FQTLYS------HGSAISESKIREFEVETERLNSRIEH 599
L LQ+ E+ Q+L S A + ++ + E ++ + E
Sbjct: 1776 REQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEER 1835
Query: 600 LKSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYELLLA----- 654
+K + D L LE+ + + ++ A L L + ++A E +L
Sbjct: 1836 VKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAE 1895
Query: 655 LAESEQSLILGQFRAAGVGSSPGDQS----------------GDENITQMLKRAHDCRKT 698
E E++L+ Q + A ++ D+ + + L+ +
Sbjct: 1896 SREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQEL-EALRAESQSSRH 1954
Query: 699 AENAAKALLMKLDGSCGGAFAV-----AGCSVQPWESLSSNSHTSTTSSTASSCDTEFTK 753
E AA+A L + G A A Q S S + T+T ++ +C +
Sbjct: 1955 QEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQ 2014
Query: 754 EDEQ-------------RLKDYIQQLKN---DRAAVKLTMLELESIHIDPLSYDVKPRGD 797
+E R ++ +QQL+ R E E + L+ V+
Sbjct: 2015 LEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMI 2074
Query: 798 SQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHL 857
++ +L +E+ + + + EL QL L +KE++ LEL+ T++ L H H
Sbjct: 2075 QEKQNLGQEREEEEIRGLHQSVREL--QLTLAQKEQEILELR-ETQQRNNLEALPH-SHK 2130
Query: 858 KSEVEEQK------EQRM-RSLSSTSSGSKDKPGKEC---ADAASPALSLAELRTTCSEN 907
S +EEQ E R+ R L + + +E A ALSLA+ + + S
Sbjct: 2131 TSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSL 2190
Query: 908 ELAAEFTNAIRREKKLKARVQELVSALERLTKSSEIRHQQSAEFVNDLKRANSNLVAAYE 967
+ A F A E+ + + + L R E H A +L V E
Sbjct: 2191 QEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGE 2250
Query: 968 KAKKKHQNKLKKLESQMMAMVERHETQVRMLKQRIALLEEENSRPHTNETSL 1019
+ + + +E Q H L+Q +A LE + SR + L
Sbjct: 2251 VSGVEAEPSPDGMEKQSWRQRLEH------LQQAVARLEIDRSRLQRHNVQL 2296
Score = 57.0 bits (136), Expect = 9e-08
Identities = 131/690 (18%), Positives = 255/690 (36%), Gaps = 91/690 (13%)
Query: 233 ERERDLLEKKLAKAQCEQSHL--MREHEDVQERTTLRYEERITELHSVIAELNKKIDRLQ 290
E + +L K + +C+Q H+ ++E +D E+ ++ E ++++ ++I LQ
Sbjct: 1725 EHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQ 1784
Query: 291 GTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTADMDNCSDLNS 350
++E E EL+ + QSQ ++E R++ Q + + + + +
Sbjct: 1785 -QQLQEAREQGELKEQSLQSQ--LDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKAD 1841
Query: 351 ELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGR-- 408
LQ L + R E+ H EQ E + + V+ +E VLG
Sbjct: 1842 ALQGALEQAHMTLKERH--------GELQDHKEQARRLEEELAVEGRRVQALEEVLGDLR 1893
Query: 409 -----------DLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKATMNAIR 457
L AE+ E E L++ A+L +++EL +A + R
Sbjct: 1894 AESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSR 1953
Query: 458 EERDRLRRRVRELQTRLQSVQATGPSSPGRL---TSTNRPINPSTGELSTSSSSNDIPIA 514
+ + R R LQ L A L +R + ST L S +
Sbjct: 1954 HQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSR 2013
Query: 515 KIAERVKLSKTR--------SESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSNIQE 566
++ E +++ + E + L + + L SL +QE
Sbjct: 2014 QLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSL--AQRVQE 2071
Query: 567 -IFQTLYSHGSAISESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAE------ 619
+ Q + G E +IR L ++ + + ++L + + ++N E
Sbjct: 2072 NMIQEKQNLGQEREEEEIRGLHQSVREL--QLTLAQKEQEILELRETQQRNNLEALPHSH 2129
Query: 620 ----------RMSMLVGKYESNATALRLALQYSE-QCIE----AYELLLALAESEQSLI- 663
++ L + + L+ AL+ +E + IE A +L L+LA+++ S+
Sbjct: 2130 KTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSS 2189
Query: 664 ---LGQFRAAGVGSSPGDQSGDENITQMLKRAHD--------CRKTAENAAKALLMKLDG 712
+ F A V +Q ++ ++ +RA + TAE ++ G
Sbjct: 2190 LQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLG 2249
Query: 713 SCGGAFAVA---GCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKND 769
G A G Q W + + D + +L+ ++Q++ +
Sbjct: 2250 EVSGVEAEPSPDGMEKQSWRQRLEHLQQAV---ARLEIDRSRLQRHNVQLRSTLEQVERE 2306
Query: 770 RAAVK---LTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQL 826
R +K + + S+ I + + D + +A + EL ++E+ L+AQL
Sbjct: 2307 RRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAEL---QKEVVLLQAQL 2363
Query: 827 YLLEKEKKALELKLSTREAQEQAYLVHIEH 856
L K+K+ TR AQ L + H
Sbjct: 2364 TLERKQKQ----DYITRSAQTSRELAGLHH 2389
Score = 45.1 bits (105), Expect = 3e-04
Identities = 136/683 (19%), Positives = 249/683 (36%), Gaps = 124/683 (18%)
Query: 412 PNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKATMNAIREE-----------R 460
PNL E R E+E ++ ESL + + + A+RE+ R
Sbjct: 94 PNLDELLVRLEEE----QQRCESLAEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRAR 149
Query: 461 DRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKI-AER 519
D L R+ + Q + + GRL S R + S+ D + ++ AE
Sbjct: 150 DELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSATDRDLMELKAEH 209
Query: 520 VKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAIS 579
V+LS + L + + V + E D ++ L
Sbjct: 210 VRLSGS-----------LLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLL-------- 250
Query: 580 ESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGK----YESNATAL 635
+K +E E E + + LKSQ DL L++ + + K YE AL
Sbjct: 251 -AKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKAL 309
Query: 636 RLALQYSEQC---IEAYELLLALAESEQSLILGQF------RAAGVGSSPGDQSGDENIT 686
R ++ E + +E L+ E+ L L Q G + SG EN
Sbjct: 310 RETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSL 369
Query: 687 QM----------------LKRAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQPWE- 729
++ L A + L +L G C A + WE
Sbjct: 370 ELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAG-CQEAVNLLQQQHDQWEE 428
Query: 730 ----------SLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLE 779
L+ T + + + ++ + L+ ++L+ +L +LE
Sbjct: 429 EGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQ-----QLEVLE 483
Query: 780 LESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLE-KEKKALEL 838
E+ + ++ +++ +GDS + E +EL E L+ L LE K+ ++L
Sbjct: 484 QEAWRLRRVNVELQLQGDSAQGQKEEQ--QEELHLAVRERERLQEMLMGLEAKQSESLSE 541
Query: 839 KLSTREAQEQAYLVHIEHLKSEVEE------QKEQRMRSLSSTSSGSKDKPGKECADAAS 892
++ REA E ++L E L+ E E + EQ + LSS+ + K E AD +
Sbjct: 542 LITLREALESSHL-EGELLRQEQTEVTAALARAEQSIAELSSSENTLK----TEVADLRA 596
Query: 893 PALSLAEL----------------------RTTCSENELAAEFTNAIR-----REKKLKA 925
A+ L+ L ++ CS E A + NA++ EK+ +A
Sbjct: 597 AAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREA 656
Query: 926 RVQELVSALERLTKSSEIRHQQSAEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMM 985
++ +L K+ E + A+ + D++ + +++ + + +LE
Sbjct: 657 LWEKNTHLEAQLQKAEEAGAELQAD-LRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQ 715
Query: 986 AMVERHETQVRMLKQRIALLEEE 1008
+ E R ++++ AL+ E+
Sbjct: 716 EAKRQEEVLARAVQEKEALVREK 738
Score = 37.0 bits (84), Expect = 0.095
Identities = 86/424 (20%), Positives = 155/424 (36%), Gaps = 47/424 (11%)
Query: 77 MNQLGADENGKISFQDFTRCRMQLVRE-IRKEEVDLSAKSDN-----SCTKKLRDRIASW 130
+ L A+ ++ R R + ++E + K L K + ++ L A+
Sbjct: 1942 LEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATL 2001
Query: 131 PTSSDNSLGALSAARESWEYDSGARDLQSPDVQSQSALQKL---LEYGGSSLHQQAALHK 187
S D E+ G ++Q D++ Q +Q+L L L Q +
Sbjct: 2002 QASLDACQAHSRQLEEALRIQEG--EIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQ 2059
Query: 188 LLTQS--PHIGNSVGGSYLELANTLHSAALASLKGDIVELNKRLQQTERERDLLEKKLAK 245
LL +S + ++ L + L + EL L Q E+E +LE + +
Sbjct: 2060 LLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQE--ILELRETQ 2117
Query: 246 AQCEQSHLMREHEDVQERTTLRYEERITELHSVIAELNKKIDRLQGT---TIREEDEYSE 302
+ L H+ T EE+ +L S+ L ++++RLQ T E E+ E
Sbjct: 2118 QRNNLEALPHSHK------TSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWRE 2171
Query: 303 LRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLENV 362
+L+ S + S+ + + Q++++ D + L EL+ LE
Sbjct: 2172 KAQDLALSLAQTKASVSSLQEVAMFL-----QASVLERDSEQ-QRLQDELELTRRALEK- 2224
Query: 363 VCGRKKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPNLAEERSRWE 422
R S + S AE+ EQ E V +E D E+ W
Sbjct: 2225 --ERLHSPGATSTAELGSRGEQGVQLGE--------VSGVEAEPSPD-----GMEKQSWR 2269
Query: 423 KELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRR-VRELQTRLQSVQATG 481
+ L L++ L + + ++T+ + ER +L+R +R Q +
Sbjct: 2270 QRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKAT 2329
Query: 482 PSSP 485
SSP
Sbjct: 2330 ASSP 2333
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 81.6 bits (200), Expect = 3e-15
Identities = 192/1020 (18%), Positives = 392/1020 (38%), Gaps = 170/1020 (16%)
Query: 94 TRCRMQLVREIRKEEVDLSAKSDNSCTKKLRDRIASWPTSSDNSLGALSAARE------- 146
TR R + E+ KE + L AK + ++ DR +N ++ +
Sbjct: 370 TRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHL 429
Query: 147 SWEYDSGARDLQSPDVQSQSALQKLLEYGGSSL----HQQAALHKLLTQSPHIGNSVGGS 202
WE + +R + + +S ++ E S L + +L K + + +SV G+
Sbjct: 430 GWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGN 489
Query: 203 Y-----LELANTLHSAALASLKGDIVELNKRLQQTER-ERDLL----------------- 239
+E N S + L+ +IV+ + LQ + +DL+
Sbjct: 490 ASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENS 549
Query: 240 EKKLAKAQCEQSHLMREHEDVQERTTLRYEERITE-------LHSVIAELNKKIDRLQ-- 290
E+++ + E HL + +++R+ + E R+ + LH I E + K+ +++
Sbjct: 550 ERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFE 609
Query: 291 GTTIREEDEY----SELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTADMDNCS 346
I++E E+ E EL H + +++ + + T++ I + + +
Sbjct: 610 KRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELE 669
Query: 347 DLNSELQRVLTGLENVV-----CGRKKSSCSLSVAEVDRHIEQLTTAS---EHCDLAIKT 398
N +L++ L +N+ ++ S E+ R++E L AS L K
Sbjct: 670 RENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKE 729
Query: 399 VEEIEGVL--GRDLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKATMNAI 456
+E + L G +L ++ R E GL EN+ L L + +++ + ++ + +
Sbjct: 730 LESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDL 789
Query: 457 REERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKI 516
E L++ + EL+ + ++ +L N+ + T +L + ++
Sbjct: 790 EMENQTLQKNLEELKISSKRLE--------QLEKENKSLEQETSQLEKDKKQLEKENKRL 841
Query: 517 AERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGS 576
++ ++ T E ++ L E + ++++ + + C ++E+ + +
Sbjct: 842 RQQAEIKDTTLEENNVKIGNLEKE------NKTLSKEIGIYKESCVRLKELEK---ENKE 892
Query: 577 AISESKIREFEVETERLNSRIEHLKSQ---NDL--LTITLEECKSNAERMSMLVGKYESN 631
+ + I + T R + E LK+Q NDL LT LE+ N ER+
Sbjct: 893 LVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERL---------- 942
Query: 632 ATALRLALQYSEQCIEAYELLLALAES--EQSLILGQFRAAGVGSSPGDQSGDENITQML 689
L + + Y+LL + ES ++SL + + + A + + + + N Q L
Sbjct: 943 -------LHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEEST---NYNQQL 992
Query: 690 KRAHDCRKTAENAAKALLMKLDGS--CGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSC 747
++ KT + +AL + D + ++G WE S +
Sbjct: 993 RQE---LKTVKKNYEALKQRQDEERMVQSSPPISG-EDNKWERESQETTRELLKVKDRLI 1048
Query: 748 DTEFT----KEDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDL 803
+ E + ++Q LK ++QL+ ++ +L L+ + + + + +L +
Sbjct: 1049 EVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQV 1108
Query: 804 ENAVLMQELMAMKEEMAELKAQLYLLEKEKKAL-----ELK---------------LSTR 843
EN+ L + ++ + A+L Q LE E +++ +LK L R
Sbjct: 1109 ENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHER 1168
Query: 844 EAQEQAYLVHIE------HLKSEVEEQK-EQRMRSLSSTSSGSKD-------KPGKECAD 889
+A E L+ H EVE + E R L +D + K +
Sbjct: 1169 QASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLE 1228
Query: 890 AASPALSLAELRTTCSENELAAEFTNAIRREKKLKARVQELVSALERLTKSSEIRHQQSA 949
+ AE + C EN+ R+ S L + T+ + H+
Sbjct: 1229 NKNHETVAAEYKKLCGEND-----------------RLNHTYSQLLKETEVLQTDHKNLK 1271
Query: 950 EFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMMAMVERHETQVRMLKQRIALLEEEN 1009
+N+ K + L A + K K+++Q Q+ + Q +L Q LEEEN
Sbjct: 1272 SLLNNSKLEQTRLEAEFSKLKEQYQ--------QLDITSTKLNNQCELLSQLKGNLEEEN 1323
Score = 69.3 bits (168), Expect = 2e-11
Identities = 165/841 (19%), Positives = 342/841 (40%), Gaps = 103/841 (12%)
Query: 219 KGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITELHSV 278
K + EL + Q + +LE +L + L HE +E L+ +LH +
Sbjct: 343 KARVEELKEDNQVLLETKTMLEDQLEGTRARSDKL---HELEKENLQLK-----AKLHDM 394
Query: 279 IAELNKKIDRLQGTTIREEDEYSEL--RSELSQSQH------EVNEDSRSMDQDQTSVSI 330
E+ + +DR + + EE+ E+ + + +S H +++ S + Q S+
Sbjct: 395 --EMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGH 452
Query: 331 PENQST---MVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTT 387
N+ T ++ +M+N S L ++ + T +++V K + ++++ ++L+
Sbjct: 453 EVNELTSSRLLKLEMENQS-LTKTVEELRTTVDSVEGNASK------ILKMEKENQRLSK 505
Query: 388 ASEHCDLAIKTVEEIEGVLG-RDLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEEL 446
E + I V+E + + ++L +L +E+++ EK + LRE +E +L + E L
Sbjct: 506 KVEILENEI--VQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHL 563
Query: 447 NRT------------KATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRL---TST 491
N+T +A + I +E L ++E ++L ++ L
Sbjct: 564 NQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEK 623
Query: 492 NRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVA 551
EL N++ KI +K++ + E+ + L E + +
Sbjct: 624 GERAEELENELHHLEKENELLQKKIT-NLKITCEKIEALEQENSELERENRKLKKTLDSF 682
Query: 552 EHLAHSLQ----DCSNIQEIFQTLYSHGSAI--SESKIREFEVETERLNSRIEHLKSQND 605
++L L+ + S + E L + ++ + K+ + ++E + L S E LK +
Sbjct: 683 KNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLE 742
Query: 606 LLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYELLLALAESEQSLILG 665
LL + ++ ER+ + + L+ L+ S + I+ E L E E +
Sbjct: 743 LLKASFKK----TERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQK 798
Query: 666 QFRAAGVGSSPGDQSGDEN--ITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAVAGC 723
+ S +Q EN + Q + +K E K L + + +
Sbjct: 799 NLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAE--------IKDT 850
Query: 724 SVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLELESI 783
+++ E+ + + T S + KE RLK+ ++ K + + L ++
Sbjct: 851 TLE--ENNVKIGNLEKENKTLSK-EIGIYKESCVRLKELEKENKELVKRATIDIKTLVTL 907
Query: 784 HIDPLSYDVKPR---GDSQRL--DLENAVLMQELMAMKEEMAELKAQLYLLEKEKKALEL 838
D +S +K + D ++L +LE L +E + E+ + + +L L K + L+
Sbjct: 908 REDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKL-LESKLESTLKK 966
Query: 839 KLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKECADAASPALSLA 898
L +E + A +E + +Q Q ++++ K + +E +SP +S
Sbjct: 967 SLEIKEEKIAALEARLEE-STNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPIS-- 1023
Query: 899 ELRTTCSENELAAEFTNAIRREKKLKARVQELVSALERLTKSSEIRHQQSAEFVNDLKRA 958
+N+ E R K+K R+ E +ER + + Q + L+
Sbjct: 1024 -----GEDNKWERESQETTRELLKVKDRLIE----VERNNATLQAEKQALKTQLKQLETQ 1074
Query: 959 NSNLVAAYEKAKKKHQNKLKKLESQMMAMVERHETQVRMLKQRIALLEEENSRPHTNETS 1018
N+NL Q ++ L+ Q +++ E++ T L+ + A L+ ENS ++ TS
Sbjct: 1075 NNNL-----------QAQILALQRQTVSLQEQNTT----LQTQNAKLQVENSTLNSQSTS 1119
Query: 1019 L 1019
L
Sbjct: 1120 L 1120
Score = 32.7 bits (73), Expect = 1.8
Identities = 36/134 (26%), Positives = 64/134 (47%), Gaps = 9/134 (6%)
Query: 483 SSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSES-SSSDRPVLGSEI 541
SS G +RP + +G STS+S+N+ + ++ +++R +S SS + +L
Sbjct: 1573 SSTGSRVHASRPASLDSGRTSTSNSNNNASLHEVKAGAVNNQSRPQSHSSGEFSLLHDHE 1632
Query: 542 SSIGVSSSVAEHLAHSLQDCSNIQ-EIFQTLYSH------GSAISE-SKIREFEVETERL 593
+ SS ++L + +Q +I +TL S GS SE +++F E+ +L
Sbjct: 1633 AWSSSGSSPIQYLKRQTRSSPVLQHKISETLESRHHKIKTGSPGSEVVTLQQFLEESNKL 1692
Query: 594 NSRIEHLKSQNDLL 607
S SQ +LL
Sbjct: 1693 TSVQIKSSSQENLL 1706
Score = 30.8 bits (68), Expect = 6.8
Identities = 53/293 (18%), Positives = 116/293 (39%), Gaps = 31/293 (10%)
Query: 740 TSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQ 799
+SS S C + K E R + +L + +A ++ ELE + + + + +
Sbjct: 228 SSSAQSPCGSPGMKRTESR-QHLSVELADAKAKIRRLRQELE----EKTEQLLDCKQELE 282
Query: 800 RLDLENAVLMQELMAMKEEMAELKAQLYLLE----KEKKALELKLSTREAQEQAYLVHIE 855
++++E L QE M + + A++Y E +EK KL + ++ + L IE
Sbjct: 283 QMEIELKRLQQENMNLLSDARS--ARMYRDELDALREKAVRVDKLESEVSRYKERLHDIE 340
Query: 856 HLKSEVEEQKEQRMRSLSSTSSGSKDKPGKECADAASPALSLAELRTTCSENELAAEFTN 915
K+ VEE KE L + + G L L+ +++ E
Sbjct: 341 FYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDM 400
Query: 916 AIRREKKLKARVQELVSA--------------LERLTKSSEIRHQQSAEFVNDLKRANSN 961
++ ++L L A LE+++++SE+ +++ S+
Sbjct: 401 DRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSS 460
Query: 962 LVAAYEKAKKKHQNKLKKLESQM------MAMVERHETQVRMLKQRIALLEEE 1008
+ E + +++L + + + + + E + + L +++ +LE E
Sbjct: 461 RLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENE 513
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 81.6 bits (200), Expect = 3e-15
Identities = 165/882 (18%), Positives = 352/882 (39%), Gaps = 109/882 (12%)
Query: 203 YLELANTLHSAA----LASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHE 258
Y ++ L SA +A++K + + + L+++E R LE+K+ E++ L + +
Sbjct: 835 YFKIKPLLKSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQ 894
Query: 259 DVQERTTLRYEERITELHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDS 318
Q+ EER +L +L K+ + EE+ +EL ++ + + E +E
Sbjct: 895 AEQDNLN-DAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELK 953
Query: 319 RSMDQDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEV 378
+ +D + +++ E + + N L + GL+ ++ K +L A
Sbjct: 954 KDIDDLELTLAKVEKEKHATENKVKN-------LTEEMAGLDEIIAKLTKEKKALQEAHQ 1006
Query: 379 ----DRHIEQ--LTTASEHCDLAIKTVEEIEGVLGRDLYPNLAEERSR---------WEK 423
D +E+ + + S+ + V+++EG L ++ + ER++ ++
Sbjct: 1007 QALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQE 1066
Query: 424 ELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSV------ 477
+ L + L L KE ++N+ + + + +L+++++E Q R++ +
Sbjct: 1067 SIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEA 1126
Query: 478 QATGPSSPGRLTS-TNRPINPSTGELSTSSSSNDIPIAKIAER-VKLSKTRSESSSSDRP 535
+ T + +L S +R + + L + + + I +R + K R + +
Sbjct: 1127 ERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRD---LEEA 1183
Query: 536 VLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVETERLNS 595
L E ++ + A+ +A + N+Q + Q L E + EF++E + + S
Sbjct: 1184 TLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKL--------EKEKSEFKLELDDVTS 1235
Query: 596 RIEHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYELLLAL 655
+E + + K+N E++S + E A R+ L+ +++ + + A
Sbjct: 1236 NMEQ-----------IIKAKANLEKVSRTL---EDQANEYRVKLEEAQRSLNDFTTQRAK 1281
Query: 656 AESEQSLILGQFRAAGVGSSPGDQSGDENITQM--LKRAHDCRKTAENAAKALLMKLDGS 713
++E + Q S + QM LKR + A+NA L
Sbjct: 1282 LQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHD 1341
Query: 714 CG------GAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLK 767
C A +Q S +NS + + + + T+E E+ K Q+L+
Sbjct: 1342 CDLLREQYEEETEAKAELQRVLS-KANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ 1400
Query: 768 NDRAAVKLTMLELESI---------HIDPLSYDV-KPRGDSQRLDLENAVLMQELMAMKE 817
+ AV+ + S+ I+ L DV + + LD + + L K+
Sbjct: 1401 DAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQ 1460
Query: 818 EMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSS 877
+ E +++L +KE ++L +L + + L H+E K E + +E+
Sbjct: 1461 KYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGE 1520
Query: 878 GSKDKPGKECADAASPALSLAELRTTCSENELAAE-----FTNAIRREKKLKARVQELVS 932
G K+ E L EL++ E E + E A ++KA ++ ++
Sbjct: 1521 GGKNVHELEKVRKQLEVEKL-ELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLA 1579
Query: 933 ALERLTKSSEIRHQQSAEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQ------MMA 986
+ + ++ HQ+ + + A + + KKK + L ++E Q M A
Sbjct: 1580 EKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAA 1639
Query: 987 MVERH---------ETQVRM---------LKQRIALLEEENS 1010
++ +TQ+++ LK+ IA++E N+
Sbjct: 1640 EAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNN 1681
Score = 74.3 bits (181), Expect = 5e-13
Identities = 167/864 (19%), Positives = 340/864 (39%), Gaps = 148/864 (17%)
Query: 216 ASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITEL 275
+ L ++ E+++RL++ + + K + E + R+ E+ TL++E L
Sbjct: 1139 SDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEA----TLQHEATAAAL 1194
Query: 276 HSV----IAELNKKIDRLQGTTIREEDEYSELRSELS----------QSQHEVNEDSRSM 321
+AEL ++ID LQ + E E SE + EL +++ + + SR++
Sbjct: 1195 RKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTL 1254
Query: 322 DQ--DQTSVSIPENQSTM--VTADMDNCSDLNSELQRVLTGLENVVCG--RKKSSCSLSV 375
+ ++ V + E Q ++ T N EL R L E ++ R K S + +
Sbjct: 1255 EDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQM 1314
Query: 376 AEVDRHIEQ-----------LTTASEHCDLAIKTVEE-------IEGVLGRDLYPNLAEE 417
++ R +E+ L +A CDL + EE ++ VL + +A+
Sbjct: 1315 EDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSK-ANSEVAQW 1373
Query: 418 RSRWEKELAGLREENESLTAMLCSK----EEELNRTKATMNAIREERDRLRRRVRELQTR 473
R+++E + EE E L + EE + A +++ + + RL+ + +L
Sbjct: 1374 RTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVD 1433
Query: 474 LQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSD 533
++ N + L + D +A+ ++ + S++ ESS +
Sbjct: 1434 VERS------------------NAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKE 1475
Query: 534 RPVLGSEISSI-GVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVETER 592
L +E+ + EHL ++ N+QE L + E E+E R
Sbjct: 1476 ARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQ---LGEGGKNVHELEKVR 1532
Query: 593 LNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYELL 652
+E L+ Q+ LEE +++ E LR L++++ I+A E+
Sbjct: 1533 KQLEVEKLELQS-----ALEEAEASLEH---------EEGKILRAQLEFNQ--IKA-EIE 1575
Query: 653 LALAESEQSLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAKALLMKLDG 712
LAE ++ + + + + L+ + D + N + K++G
Sbjct: 1576 RKLAEKDEEMEQAK-------------RNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEG 1622
Query: 713 S----------CGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDY 762
A A V+ +SL ++ + ++ D + +R +
Sbjct: 1623 DLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNL 1682
Query: 763 IQ-QLKNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAMKEEMAE 821
+Q +L+ RA V+ T + + + + Q L +N L+ + M+ ++ +
Sbjct: 1683 LQAELEELRAVVEQTERSRKLAEQELIETSERV----QLLHSQNTSLINQKKKMESDLTQ 1738
Query: 822 LKAQLYLL--------EKEKKALE--LKLSTREAQEQAYLVHIEHLKSEVEE-------- 863
L++++ EK KKA+ ++ +EQ H+E +K +E+
Sbjct: 1739 LQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHR 1798
Query: 864 --QKEQ-----RMRSLSSTSSGSKDKPGKECADAASPALSLAELRTTCSENELAAEFTNA 916
+ EQ + L + ++ G+ A+ A S+ +R SE + E T
Sbjct: 1799 LDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRK--SERRIK-ELTYQ 1855
Query: 917 IRREKKLKARVQELVSALERLTKSSEIRHQQSAEFVN----DLKRANSNLVAAYEKA--K 970
+KK R+Q+LV L+ K+ + + +++ E N ++ L A E+A
Sbjct: 1856 TEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIA 1915
Query: 971 KKHQNKLKKLESQMMAMVERHETQ 994
+ NKL+ + A + H+ +
Sbjct: 1916 ESQVNKLRAKSRDIGAKQKMHDEE 1939
Score = 73.6 bits (179), Expect = 9e-13
Identities = 180/968 (18%), Positives = 374/968 (38%), Gaps = 192/968 (19%)
Query: 89 SFQDFTRCRMQLVREIRKEEVDLSAKSDN---------SCTKKLRDRIASWPTSSDNSLG 139
S D ++QL +++K+E D++ ++ KKL++ A +
Sbjct: 1067 SIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEE--- 1123
Query: 140 ALSAARESWEYDSGARDLQSPDVQSQSALQKLLEYGGSSLHQQAALHKLLTQSPHIGNSV 199
L A R + R S +++ S ++L E GG++ Q K + +
Sbjct: 1124 -LEAERTARAKVEKLRSDLSRELEEIS--ERLEEAGGATSVQIEMNKKREAEFQKMRRD- 1179
Query: 200 GGSYLELANTLHSAALASLK----GDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMR 255
LE A H A A+L+ + EL +++ +R + LEK E+S
Sbjct: 1180 ----LEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEK-------EKSEFKL 1228
Query: 256 EHEDVQERTTLRYEERITELHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVN 315
E +DV E+I + + + ++++ + ED+ +E R +L ++Q +N
Sbjct: 1229 ELDDVTSNM-----EQIIKAKANLEKVSRTL----------EDQANEYRVKLEEAQRSLN 1273
Query: 316 EDSRSMDQDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLENVV--CGRKKSSCSL 373
+ + + QT N EL R L E ++ R K S +
Sbjct: 1274 DFTTQRAKLQTE---------------------NGELARQLEEKEALISQLTRGKLSYTQ 1312
Query: 374 SVAEVDRHIEQ-----------LTTASEHCDLAIKTVE-------EIEGVLGRDLYPNLA 415
+ ++ R +E+ L +A CDL + E E++ VL + +A
Sbjct: 1313 QMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSK-ANSEVA 1371
Query: 416 EERSRWE----KELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQ 471
+ R+++E + L E + L L EE + A +++ + + RL+ + +L
Sbjct: 1372 QWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLM 1431
Query: 472 TRLQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSS 531
++ N + L + D +A+ ++ + S++ ESS
Sbjct: 1432 VDVER------------------SNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQ 1473
Query: 532 SDRPVLGSEISSI-GVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVET 590
+ L +E+ + EHL ++ N+QE L + E E+E
Sbjct: 1474 KEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQ---LGEGGKNVHELEK 1530
Query: 591 ERLNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYE 650
R +E L+ Q+ LEE +++ E LR L++++ I+A E
Sbjct: 1531 VRKQLEVEKLELQS-----ALEEAEASLE---------HEEGKILRAQLEFNQ--IKA-E 1573
Query: 651 LLLALAESEQSLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAKALLMKL 710
+ LAE ++ + + + + L+ + D + N + K+
Sbjct: 1574 IERKLAEKDEEM-------------EQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKM 1620
Query: 711 DGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDR 770
+G + +++ + S + DT+ +D R D LK +
Sbjct: 1621 EGDLN----EMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRAND---DLKENI 1673
Query: 771 AAVK----LTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQL 826
A V+ L ELE + R ++ + + QEL+ E + L +Q
Sbjct: 1674 AIVERRNNLLQAELEEL-----------RAVVEQTERSRKLAEQELIETSERVQLLHSQN 1722
Query: 827 YLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKE 886
L +KK +E L+ +++ +E E +E+ ++++ + +++ ++
Sbjct: 1723 TSLINQKKKMESDLTQLQSE-------VEEAVQECRNAEEKAKKAITDAAMMAEELKKEQ 1775
Query: 887 CADAASPAL------SLAELRTTCSENELAAEFTNAIRREKKLKARVQELVSALERLTKS 940
A + ++ +L+ E E A ++ +KL+ARV+EL L
Sbjct: 1776 DTSAHLERMKKNMEQTIKDLQHRLDEAEQIA-LKGGKKQLQKLEARVRELEGEL------ 1828
Query: 941 SEIRHQQSAEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMMAMVERHETQVRMLKQ 1000
E +++AE V ++++ + + ++ +N L+ + +V++ + +V+ K+
Sbjct: 1829 -EAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLLR-----LQDLVDKLQLKVKAYKR 1882
Query: 1001 RIALLEEE 1008
+ EE+
Sbjct: 1883 QAEEAEEQ 1890
Score = 56.2 bits (134), Expect = 2e-07
Identities = 157/844 (18%), Positives = 324/844 (38%), Gaps = 134/844 (15%)
Query: 71 ESVAEIMNQLGADENGKISFQDFTRCRMQLVREIRKEEVDLSAKSDNSCTKKLRDRIASW 130
E ++E + + G + +I Q +R +E + + KK D +A
Sbjct: 1146 EEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAEL 1205
Query: 131 PTSSDNSLGALSAARESWEYDSGARDLQSPDVQS--------QSALQKLL--------EY 174
DN L ++ E + L+ DV S ++ L+K+ EY
Sbjct: 1206 GEQIDN----LQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEY 1261
Query: 175 GGSSLHQQAALHKLLTQSPHIGNSVGGSYLELANTLHS--AALASLKGDIVELNKRLQQT 232
Q +L+ TQ + G ELA L A ++ L + ++++
Sbjct: 1262 RVKLEEAQRSLNDFTTQRAKLQTENG----ELARQLEEKEALISQLTRGKLSYTQQMEDL 1317
Query: 233 ERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERI---TELHSVIAELNKKI--- 286
+R+ LE++ KA+ +H ++ + +YEE EL V+++ N ++
Sbjct: 1318 KRQ---LEEE-GKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQW 1373
Query: 287 -DRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTADMDNC 345
+ + I+ +E E + +L+Q + E V A C
Sbjct: 1374 RTKYETDAIQRTEELEEAKKKLAQRLQDAEE--------------------AVEAVNAKC 1413
Query: 346 SDLNSELQRVLTGLENVVCGRKKSSCSLSVAEV-DRHIEQLTTASEHCDLAIKTVEEIEG 404
S L R+ +E+++ ++S+ + + + R+ +++ + ++ E
Sbjct: 1414 SSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQ 1473
Query: 405 VLGRDLYPNLAEERSRWEKELAGL---REENESLTAMLCSKEEELNRTKATMNAIREERD 461
R L L + ++ +E+ L L + EN++L + E+L ++ + + R
Sbjct: 1474 KEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRK 1533
Query: 462 RLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIA---E 518
+L ELQ+ L+ +A+ G++ N E+ + D + + +
Sbjct: 1534 QLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQ 1593
Query: 519 RV--KLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGS 576
RV L + + S VL + G + + L+H+ + + Q+ ++L S
Sbjct: 1594 RVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQ---S 1650
Query: 577 AISESKIREFEV--ETERLNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATA 634
+ +++I+ + + L I ++ +N+LL LEE ++ E+ S A
Sbjct: 1651 LLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTE------RSRKLA 1704
Query: 635 LRLALQYSEQCIEAYELLLALAESEQSLILGQFRAAGVGSSPGDQSGDENITQML----K 690
+ ++ SE+ + L S+ + ++ Q + + ++TQ+ +
Sbjct: 1705 EQELIETSER--------VQLLHSQNTSLINQ-----------KKKMESDLTQLQSEVEE 1745
Query: 691 RAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTE 750
+CR E A KA+ A +A E L TS
Sbjct: 1746 AVQECRNAEEKAKKAIT--------DAAMMA-------EELKKEQDTSAHLE-------R 1783
Query: 751 FTKEDEQRLKDYIQQL-KNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLM 809
K EQ +KD +L + ++ A+K +L+ + + + R L+ E
Sbjct: 1784 MKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKL-------EARVRELEGELEAEQKRNA 1836
Query: 810 QELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRM 869
+ + M++ +K Y E++KK L L+L + Q + ++ K + EE +EQ
Sbjct: 1837 ESVKGMRKSERRIKELTYQTEEDKKNL-LRLQDLVDKLQ---LKVKAYKRQAEEAEEQAN 1892
Query: 870 RSLS 873
+LS
Sbjct: 1893 TNLS 1896
Score = 40.8 bits (94), Expect = 0.007
Identities = 51/231 (22%), Positives = 109/231 (47%), Gaps = 29/231 (12%)
Query: 788 LSYDVKPRGDSQRLDLENAVLMQELMAMKEEM-------AELKAQLYLLEKEKKALELKL 840
L + +KP S + E A + +E +KE + EL+ ++ L +EK L+L++
Sbjct: 834 LYFKIKPLLKSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQV 893
Query: 841 -----STREAQEQA--YLVHIEHLKSEVEEQKE--QRMRSLSSTSSGSKDKPGKECADAA 891
+ +A+E+ + + L+++V+E E + +++ + K K EC++
Sbjct: 894 QAEQDNLNDAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELK 953
Query: 892 SPALSLAELRTTCSENELAAEFT-NAIRREKKLKARVQELVSALERLTKSSEIRHQQSAE 950
+ +L T ++ E T N ++ + A + E+++ L + K+ + HQQ+
Sbjct: 954 K---DIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQA-- 1008
Query: 951 FVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMMAMVERHETQVRMLKQR 1001
++DL + + V + K+K K + ++ LE + E +VRM +R
Sbjct: 1009 -LDDL-QVEEDKVNSLSKSKVKLEQQVDDLEGSL-----EQEKKVRMDLER 1052
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 80.9 bits (198), Expect = 6e-15
Identities = 171/839 (20%), Positives = 316/839 (37%), Gaps = 108/839 (12%)
Query: 221 DIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITELHSVIA 280
++ EL R+ Q E ER L ++L +A+ E L E E+ + R R +E L V++
Sbjct: 899 EVGELQGRVAQLEEERARLAEQL-RAEAE---LCAEAEETRGRLAARKQE----LELVVS 950
Query: 281 ELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTA 340
EL ++ + + + + E L+ + + + + + + + Q E +
Sbjct: 951 ELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEE 1010
Query: 341 DMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVE 400
D+ D NS+L + LE+ + + S AE + ++ L + I +E
Sbjct: 1011 DLLLLEDQNSKLSKERKLLED-----RLAEFSSQAAEEEEKVKSLNKLRLKYEATIADME 1065
Query: 401 -----------EIEGVLGR------DLYPNLAEERSRWEKELAGLREENESLTAMLCSKE 443
E+E + R +L + E++ R E+ A L + E L A L E
Sbjct: 1066 DRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAE 1125
Query: 444 EELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELS 503
+E + ++RE + L E Q L+S + + + + GEL
Sbjct: 1126 DEGGARAQLLKSLREAQAAL----AEAQEDLESERVARTKAEKQRRDLGEELEALRGELE 1181
Query: 504 TSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSN 563
+ S + A++ SK E L +L++ +
Sbjct: 1182 DTLDSTN------AQQELRSKREQE----------------------VTELKKTLEEETR 1213
Query: 564 IQE--IFQTLYSHGSAISESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERM 621
I E + + HG A+ E + E + R E + L + E + AE
Sbjct: 1214 IHEAAVQELRQRHGQALGE--LAEQLEQARRGKGAWEKTR-----LALEAEVSELRAELS 1266
Query: 622 SMLVGKYESNATALRLALQYSEQCIEAYELLLALAESEQSLILGQFRAAGVGSSPGDQSG 681
S+ + E RL LQ E A + A AE+ + L Q V + +
Sbjct: 1267 SLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAES 1326
Query: 682 -----DENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNSH 736
+ ++ + HD ++ + +A L AG Q E ++
Sbjct: 1327 KTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARER 1386
Query: 737 TSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDVKPRG 796
TA + +E+ + E+ + R A + + + + D RG
Sbjct: 1387 AGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERG 1446
Query: 797 --------DSQRLDLENAVLMQELMAMKEE-----MAELKAQLYLLEKEKKALELKLSTR 843
D +DLE + + K+ +AE KA + +E++ E + R
Sbjct: 1447 RRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGRER 1506
Query: 844 EAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSS---GSKDKPGKECAD------AASPA 894
EA+ + +E + E E+ E++ R+L + SKD GK + A A
Sbjct: 1507 EARALSLTRALEE-EQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQA 1565
Query: 895 LSLAELRTTCSENELAAEFTNAIRREKKLKARVQELVSALERLTKSSEIRHQQ------S 948
+ + T E+EL A +R E ++A + L+ ++ E R +Q
Sbjct: 1566 ANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRD 1625
Query: 949 AEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMMAMVERHETQVRMLKQRIALLEE 1007
AE D +R L A A+KK + +L++L++QM + + E V+ L++ A ++E
Sbjct: 1626 AEVERDEERKQRTLAVA---ARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKE 1681
Score = 80.1 bits (196), Expect = 1e-14
Identities = 188/899 (20%), Positives = 337/899 (37%), Gaps = 132/899 (14%)
Query: 204 LELANTLHSAALASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQ-- 261
L+L A + + D++ L + + +ER LLE +LA+ S E E V+
Sbjct: 994 LQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEF---SSQAAEEEEKVKSL 1050
Query: 262 ERTTLRYEERITEL----------HSVIAELNKKID----RLQGTTIREEDEYSELRSEL 307
+ L+YE I ++ + +L +++D LQ + ++ ELR++L
Sbjct: 1051 NKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQL 1110
Query: 308 SQSQHEVNED-SRSMDQD----QTSVSIPENQSTMVTADMDNCS-------------DLN 349
+ + E+ +R+ D+ Q S+ E Q+ + A D S DL
Sbjct: 1111 GRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLG 1170
Query: 350 SELQRVLTGLENVVCGRK-----KSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEG 404
EL+ + LE+ + +S V E+ + +E+ T E A++ + + G
Sbjct: 1171 EELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHE---AAVQELRQRHG 1227
Query: 405 VLGRDLYPNLAEER---SRWEK-------ELAGLREENESLTAMLCSKEEELNRTKATMN 454
+L L + R WEK E++ LR E SL E+ R + +
Sbjct: 1228 QALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQ 1287
Query: 455 AIREERDRLRRRVRELQTRLQSVQATGPSSPGRLT-STNRPINPSTGELSTSSSSNDIPI 513
++ R E +LQ QA + G L + ++ I S ST + +D
Sbjct: 1288 EVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHD--- 1344
Query: 514 AKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLA-------------HSLQD 560
A+ + +TR++ + R V E + G+ + E A L +
Sbjct: 1345 ---AQELLQEETRAKLALGSR-VRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSE 1400
Query: 561 CSNIQEIFQTLYSHGSAISESKIREFEVETERLNSR---IEHLKSQNDLLTITLEECKSN 617
QE G RE E T+RL + ++ L+ L L++ +
Sbjct: 1401 WRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMD 1460
Query: 618 AERMSMLVGKYESNATALRLALQYSEQCIEAYELLLALAESEQSLILGQFRAAGVGSSPG 677
E+ LV E L + + L A+ E E++ G+ R A S
Sbjct: 1461 LEQQRQLVSTLEKKQRKFDQLLAEEKAAV-----LRAVEERERAEAEGREREARALS--- 1512
Query: 678 DQSGDENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNSHT 737
+T+ L+ + R+ E +AL +L+ V G SV E +
Sbjct: 1513 -------LTRALEEEQEAREELERQNRALRAELEALLSSKDDV-GKSVHELERACRVAEQ 1564
Query: 738 STTSSTASSCDTE----FTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDPLS---Y 790
+ A + E ++ + RL+ +Q LK E L+
Sbjct: 1565 AANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLR 1624
Query: 791 DVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAY 850
D + D +R AV ++ ++ E+ ELKAQ+ + K+ +L +AQ
Sbjct: 1625 DAEVERDEERKQRTLAVAARK--KLEGELEELKAQMASAGQGKEEAVKQLRKMQAQ---- 1678
Query: 851 LVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKEC----ADAASPALSLAELRTTCSE 906
++ L EVEE + R S K G E A A +
Sbjct: 1679 ---MKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDR 1735
Query: 907 NELAAEFTN------AIRREKK-LKARVQELVSALERLTKSSEIRHQQ------SAEFVN 953
+E+A E N AI EK+ L+ R+ +L LE +SE+ + + E +
Sbjct: 1736 DEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLT 1795
Query: 954 DLKRANSNLVAAYEKAKKKHQNKLKKLESQM----MAMVERHETQVRMLKQRIALLEEE 1008
A + A E +++ + ++++L ++ RH+ + L+ ++A EE+
Sbjct: 1796 TELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQ 1854
Score = 61.2 bits (147), Expect = 5e-09
Identities = 202/1001 (20%), Positives = 361/1001 (36%), Gaps = 153/1001 (15%)
Query: 83 DENGKISFQDFTRCRMQLVREIRKEEVDLSAKSDNSCTK---KLRDRIASWPTSSDNSLG 139
D+N K+S + + + E R E A + K KLR + + ++ L
Sbjct: 1017 DQNSKLS-------KERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLR 1069
Query: 140 ALSAARESWE-----YDSGARDLQSPDVQSQSALQKL-LEYGGSSLHQQAALHKLLTQSP 193
R+ E D + +LQ V+ Q ++L + G QAAL +
Sbjct: 1070 KEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALAR------ 1123
Query: 194 HIGNSVGGSYLELANTLHSA--ALASLKGDIV-ELNKRLQQTERERDL----------LE 240
GG+ +L +L A ALA + D+ E R + ++ RDL LE
Sbjct: 1124 --AEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELE 1181
Query: 241 KKLAKAQCEQSHLMREHEDVQE-RTTLRYEERITELH---------SVIAELNKKIDRL- 289
L +Q + ++V E + TL E RI E + EL +++++
Sbjct: 1182 DTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQAR 1241
Query: 290 ------QGTTIREEDEYSELRSELSQSQ---HEVNEDSRSMDQDQTSVSIPENQSTMVTA 340
+ T + E E SELR+ELS Q E + R ++ V A
Sbjct: 1242 RGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARA 1301
Query: 341 D-MDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRH-IEQLTTASEHCDLAIKT 398
+ + +EL+ V L + S LS E H ++L LA+
Sbjct: 1302 EAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLAL-- 1359
Query: 399 VEEIEGVLGRDLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKATMNAIRE 458
G R + A R + E+E A L E R + A+
Sbjct: 1360 -----GSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEA 1414
Query: 459 ERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAE 518
+ RR RE + Q + A + RL R + + + ++ + +
Sbjct: 1415 GEEARRRAAREAEALTQRL-AEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEK 1473
Query: 519 RV-KLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSA 577
+ K + +E ++ VL + + E A +L ++E
Sbjct: 1474 KQRKFDQLLAEEKAA---VLRAVEERERAEAEGREREARALSLTRALEE----------- 1519
Query: 578 ISESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALRL 637
+ E E + L + +E L S D + ++ E + + T L
Sbjct: 1520 -EQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELED 1578
Query: 638 ALQYSEQCIEAYELLL-ALAESEQSLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDC- 695
L +E E+ + AL + + G+ D++G+E Q+ K+ D
Sbjct: 1579 ELTAAEDAKLRLEVTVQALKTQHERDLQGR-----------DEAGEERRRQLAKQLRDAE 1627
Query: 696 -----RKTAENAAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTE 750
+ A A KL+G A + Q E + E
Sbjct: 1628 VERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVE 1687
Query: 751 FTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIHI-DPLSYDVKPRGDSQ--RLDLENAV 807
T+ + + +N + +L LE E + + + L+ + R +Q R ++ + V
Sbjct: 1688 ETRTSREEIFS-----QNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEV 1742
Query: 808 LMQEL--MAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAY---LVHIEHLKSEVE 862
L A+ EE +L+ +L LE+E LE + S E Y L+ +E L +E+
Sbjct: 1743 ANGNLSKAAILEEKRQLEGRLGQLEEE---LEEEQSNSELLNDRYRKLLLQVESLTTELS 1799
Query: 863 EQKEQRMRSLSSTSSGSKDKPGKECADAASPALSLAELRTTCSENELAAEFTNAIRREKK 922
+ RS S+ + + + ++ + ELR E + A
Sbjct: 1800 AE-----RSFSAKAESGRQQLERQ----------IQELRGRLGEEDAGA----------- 1833
Query: 923 LKARVQELVSALE-RLTKSSEIRHQQSAEFVNDLKRANSNLVAAYEKAKKK---HQNKLK 978
+AR + ++ALE +L ++ E Q++ E + + LV EK K+ + +
Sbjct: 1834 -RARHKMTIAALESKLAQAEEQLEQETRERI-----LSGKLVRRAEKRLKEVVLQVEEER 1887
Query: 979 KLESQMMAMVERHETQVRMLKQRIALLEEENSRPHTNETSL 1019
++ Q+ +E+ +V+ LK+++ EEE SR L
Sbjct: 1888 RVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRL 1928
Score = 37.0 bits (84), Expect = 0.095
Identities = 24/122 (19%), Positives = 62/122 (50%), Gaps = 5/122 (4%)
Query: 207 ANTLHSAALASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTL 266
A H +A+L+ + + ++L+Q RER L K + +A+ ++ + E+ + R
Sbjct: 1833 ARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEE-ERRVAD 1891
Query: 267 RYEERITELHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQT 326
+ +++ + + + +L ++++ + R + L+ EL +V E + SM+++ T
Sbjct: 1892 QLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQREL----EDVTESAESMNREVT 1947
Query: 327 SV 328
++
Sbjct: 1948 TL 1949
Score = 31.6 bits (70), Expect = 4.0
Identities = 59/250 (23%), Positives = 100/250 (40%), Gaps = 32/250 (12%)
Query: 82 ADE--NGKISFQDFTRCRMQLVREIRKEEVDLSAKSDNSCTKKLRDRIASWPTSSDNSLG 139
ADE NG +S + QL + + E +L + NS + L DR ++
Sbjct: 1739 ADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNS--ELLNDRYRKLLLQVESLTT 1796
Query: 140 ALSAARE-SWEYDSGARDLQSPDVQSQSALQKLLEYGGSSLHQQ--AALHKLLTQSPH-- 194
LSA R S + +SG + L+ + + L + + G + H+ AAL L Q+
Sbjct: 1797 ELSAERSFSAKAESGRQQLERQIQELRGRLGEE-DAGARARHKMTIAALESKLAQAEEQL 1855
Query: 195 ---------IGNSVGGSYLELANTL-----HSAALASLKGDIVELNKRLQQTERERDLLE 240
G V + L + L+ + + N R++Q +R+ + E
Sbjct: 1856 EQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAE 1915
Query: 241 KKLAKAQCEQSHLMREHEDV--------QERTTLRYEERITELHSVIAELNKKIDRLQGT 292
++ ++AQ + L RE EDV +E TTLR R L + + +G
Sbjct: 1916 EEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEEGV 1975
Query: 293 TIREEDEYSE 302
EE E ++
Sbjct: 1976 ASDEEAEEAQ 1985
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 80.9 bits (198), Expect = 6e-15
Identities = 171/839 (20%), Positives = 316/839 (37%), Gaps = 108/839 (12%)
Query: 221 DIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITELHSVIA 280
++ EL R+ Q E ER L ++L +A+ E L E E+ + R R +E L V++
Sbjct: 891 EVGELQGRVAQLEEERARLAEQL-RAEAE---LCAEAEETRGRLAARKQE----LELVVS 942
Query: 281 ELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTA 340
EL ++ + + + + E L+ + + + + + + + Q E +
Sbjct: 943 ELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEE 1002
Query: 341 DMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVE 400
D+ D NS+L + LE+ + + S AE + ++ L + I +E
Sbjct: 1003 DLLLLEDQNSKLSKERKLLED-----RLAEFSSQAAEEEEKVKSLNKLRLKYEATIADME 1057
Query: 401 -----------EIEGVLGR------DLYPNLAEERSRWEKELAGLREENESLTAMLCSKE 443
E+E + R +L + E++ R E+ A L + E L A L E
Sbjct: 1058 DRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAE 1117
Query: 444 EELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELS 503
+E + ++RE + L E Q L+S + + + + GEL
Sbjct: 1118 DEGGARAQLLKSLREAQAAL----AEAQEDLESERVARTKAEKQRRDLGEELEALRGELE 1173
Query: 504 TSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSN 563
+ S + A++ SK E L +L++ +
Sbjct: 1174 DTLDSTN------AQQELRSKREQE----------------------VTELKKTLEEETR 1205
Query: 564 IQE--IFQTLYSHGSAISESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERM 621
I E + + HG A+ E + E + R E + L + E + AE
Sbjct: 1206 IHEAAVQELRQRHGQALGE--LAEQLEQARRGKGAWEKTR-----LALEAEVSELRAELS 1258
Query: 622 SMLVGKYESNATALRLALQYSEQCIEAYELLLALAESEQSLILGQFRAAGVGSSPGDQSG 681
S+ + E RL LQ E A + A AE+ + L Q V + +
Sbjct: 1259 SLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAES 1318
Query: 682 -----DENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNSH 736
+ ++ + HD ++ + +A L AG Q E ++
Sbjct: 1319 KTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARER 1378
Query: 737 TSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDVKPRG 796
TA + +E+ + E+ + R A + + + + D RG
Sbjct: 1379 AGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERG 1438
Query: 797 --------DSQRLDLENAVLMQELMAMKEE-----MAELKAQLYLLEKEKKALELKLSTR 843
D +DLE + + K+ +AE KA + +E++ E + R
Sbjct: 1439 RRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGRER 1498
Query: 844 EAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSS---GSKDKPGKECAD------AASPA 894
EA+ + +E + E E+ E++ R+L + SKD GK + A A
Sbjct: 1499 EARALSLTRALEE-EQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQA 1557
Query: 895 LSLAELRTTCSENELAAEFTNAIRREKKLKARVQELVSALERLTKSSEIRHQQ------S 948
+ + T E+EL A +R E ++A + L+ ++ E R +Q
Sbjct: 1558 ANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRD 1617
Query: 949 AEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMMAMVERHETQVRMLKQRIALLEE 1007
AE D +R L A A+KK + +L++L++QM + + E V+ L++ A ++E
Sbjct: 1618 AEVERDEERKQRTLAVA---ARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKE 1673
Score = 80.1 bits (196), Expect = 1e-14
Identities = 188/899 (20%), Positives = 337/899 (37%), Gaps = 132/899 (14%)
Query: 204 LELANTLHSAALASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQ-- 261
L+L A + + D++ L + + +ER LLE +LA+ S E E V+
Sbjct: 986 LQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEF---SSQAAEEEEKVKSL 1042
Query: 262 ERTTLRYEERITEL----------HSVIAELNKKID----RLQGTTIREEDEYSELRSEL 307
+ L+YE I ++ + +L +++D LQ + ++ ELR++L
Sbjct: 1043 NKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQL 1102
Query: 308 SQSQHEVNED-SRSMDQD----QTSVSIPENQSTMVTADMDNCS-------------DLN 349
+ + E+ +R+ D+ Q S+ E Q+ + A D S DL
Sbjct: 1103 GRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLG 1162
Query: 350 SELQRVLTGLENVVCGRK-----KSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEG 404
EL+ + LE+ + +S V E+ + +E+ T E A++ + + G
Sbjct: 1163 EELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHE---AAVQELRQRHG 1219
Query: 405 VLGRDLYPNLAEER---SRWEK-------ELAGLREENESLTAMLCSKEEELNRTKATMN 454
+L L + R WEK E++ LR E SL E+ R + +
Sbjct: 1220 QALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQ 1279
Query: 455 AIREERDRLRRRVRELQTRLQSVQATGPSSPGRLT-STNRPINPSTGELSTSSSSNDIPI 513
++ R E +LQ QA + G L + ++ I S ST + +D
Sbjct: 1280 EVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHD--- 1336
Query: 514 AKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLA-------------HSLQD 560
A+ + +TR++ + R V E + G+ + E A L +
Sbjct: 1337 ---AQELLQEETRAKLALGSR-VRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSE 1392
Query: 561 CSNIQEIFQTLYSHGSAISESKIREFEVETERLNSR---IEHLKSQNDLLTITLEECKSN 617
QE G RE E T+RL + ++ L+ L L++ +
Sbjct: 1393 WRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMD 1452
Query: 618 AERMSMLVGKYESNATALRLALQYSEQCIEAYELLLALAESEQSLILGQFRAAGVGSSPG 677
E+ LV E L + + L A+ E E++ G+ R A S
Sbjct: 1453 LEQQRQLVSTLEKKQRKFDQLLAEEKAAV-----LRAVEERERAEAEGREREARALS--- 1504
Query: 678 DQSGDENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNSHT 737
+T+ L+ + R+ E +AL +L+ V G SV E +
Sbjct: 1505 -------LTRALEEEQEAREELERQNRALRAELEALLSSKDDV-GKSVHELERACRVAEQ 1556
Query: 738 STTSSTASSCDTE----FTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDPLS---Y 790
+ A + E ++ + RL+ +Q LK E L+
Sbjct: 1557 AANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLR 1616
Query: 791 DVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAY 850
D + D +R AV ++ ++ E+ ELKAQ+ + K+ +L +AQ
Sbjct: 1617 DAEVERDEERKQRTLAVAARK--KLEGELEELKAQMASAGQGKEEAVKQLRKMQAQ---- 1670
Query: 851 LVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKEC----ADAASPALSLAELRTTCSE 906
++ L EVEE + R S K G E A A +
Sbjct: 1671 ---MKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDR 1727
Query: 907 NELAAEFTN------AIRREKK-LKARVQELVSALERLTKSSEIRHQQ------SAEFVN 953
+E+A E N AI EK+ L+ R+ +L LE +SE+ + + E +
Sbjct: 1728 DEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLT 1787
Query: 954 DLKRANSNLVAAYEKAKKKHQNKLKKLESQM----MAMVERHETQVRMLKQRIALLEEE 1008
A + A E +++ + ++++L ++ RH+ + L+ ++A EE+
Sbjct: 1788 TELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQ 1846
Score = 61.2 bits (147), Expect = 5e-09
Identities = 202/1001 (20%), Positives = 361/1001 (36%), Gaps = 153/1001 (15%)
Query: 83 DENGKISFQDFTRCRMQLVREIRKEEVDLSAKSDNSCTK---KLRDRIASWPTSSDNSLG 139
D+N K+S + + + E R E A + K KLR + + ++ L
Sbjct: 1009 DQNSKLS-------KERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLR 1061
Query: 140 ALSAARESWE-----YDSGARDLQSPDVQSQSALQKL-LEYGGSSLHQQAALHKLLTQSP 193
R+ E D + +LQ V+ Q ++L + G QAAL +
Sbjct: 1062 KEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALAR------ 1115
Query: 194 HIGNSVGGSYLELANTLHSA--ALASLKGDIV-ELNKRLQQTERERDL----------LE 240
GG+ +L +L A ALA + D+ E R + ++ RDL LE
Sbjct: 1116 --AEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELE 1173
Query: 241 KKLAKAQCEQSHLMREHEDVQE-RTTLRYEERITELH---------SVIAELNKKIDRL- 289
L +Q + ++V E + TL E RI E + EL +++++
Sbjct: 1174 DTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQAR 1233
Query: 290 ------QGTTIREEDEYSELRSELSQSQ---HEVNEDSRSMDQDQTSVSIPENQSTMVTA 340
+ T + E E SELR+ELS Q E + R ++ V A
Sbjct: 1234 RGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARA 1293
Query: 341 D-MDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRH-IEQLTTASEHCDLAIKT 398
+ + +EL+ V L + S LS E H ++L LA+
Sbjct: 1294 EAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLAL-- 1351
Query: 399 VEEIEGVLGRDLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKATMNAIRE 458
G R + A R + E+E A L E R + A+
Sbjct: 1352 -----GSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEA 1406
Query: 459 ERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAE 518
+ RR RE + Q + A + RL R + + + ++ + +
Sbjct: 1407 GEEARRRAAREAEALTQRL-AEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEK 1465
Query: 519 RV-KLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSA 577
+ K + +E ++ VL + + E A +L ++E
Sbjct: 1466 KQRKFDQLLAEEKAA---VLRAVEERERAEAEGREREARALSLTRALEE----------- 1511
Query: 578 ISESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALRL 637
+ E E + L + +E L S D + ++ E + + T L
Sbjct: 1512 -EQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELED 1570
Query: 638 ALQYSEQCIEAYELLL-ALAESEQSLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDC- 695
L +E E+ + AL + + G+ D++G+E Q+ K+ D
Sbjct: 1571 ELTAAEDAKLRLEVTVQALKTQHERDLQGR-----------DEAGEERRRQLAKQLRDAE 1619
Query: 696 -----RKTAENAAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTE 750
+ A A KL+G A + Q E + E
Sbjct: 1620 VERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVE 1679
Query: 751 FTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIHI-DPLSYDVKPRGDSQ--RLDLENAV 807
T+ + + +N + +L LE E + + + L+ + R +Q R ++ + V
Sbjct: 1680 ETRTSREEIFS-----QNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEV 1734
Query: 808 LMQEL--MAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAY---LVHIEHLKSEVE 862
L A+ EE +L+ +L LE+E LE + S E Y L+ +E L +E+
Sbjct: 1735 ANGNLSKAAILEEKRQLEGRLGQLEEE---LEEEQSNSELLNDRYRKLLLQVESLTTELS 1791
Query: 863 EQKEQRMRSLSSTSSGSKDKPGKECADAASPALSLAELRTTCSENELAAEFTNAIRREKK 922
+ RS S+ + + + ++ + ELR E + A
Sbjct: 1792 AE-----RSFSAKAESGRQQLERQ----------IQELRGRLGEEDAGA----------- 1825
Query: 923 LKARVQELVSALE-RLTKSSEIRHQQSAEFVNDLKRANSNLVAAYEKAKKK---HQNKLK 978
+AR + ++ALE +L ++ E Q++ E + + LV EK K+ + +
Sbjct: 1826 -RARHKMTIAALESKLAQAEEQLEQETRERI-----LSGKLVRRAEKRLKEVVLQVEEER 1879
Query: 979 KLESQMMAMVERHETQVRMLKQRIALLEEENSRPHTNETSL 1019
++ Q+ +E+ +V+ LK+++ EEE SR L
Sbjct: 1880 RVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRL 1920
Score = 37.0 bits (84), Expect = 0.095
Identities = 24/122 (19%), Positives = 62/122 (50%), Gaps = 5/122 (4%)
Query: 207 ANTLHSAALASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTL 266
A H +A+L+ + + ++L+Q RER L K + +A+ ++ + E+ + R
Sbjct: 1825 ARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEE-ERRVAD 1883
Query: 267 RYEERITELHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQT 326
+ +++ + + + +L ++++ + R + L+ EL +V E + SM+++ T
Sbjct: 1884 QLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQREL----EDVTESAESMNREVT 1939
Query: 327 SV 328
++
Sbjct: 1940 TL 1941
Score = 31.6 bits (70), Expect = 4.0
Identities = 59/250 (23%), Positives = 100/250 (40%), Gaps = 32/250 (12%)
Query: 82 ADE--NGKISFQDFTRCRMQLVREIRKEEVDLSAKSDNSCTKKLRDRIASWPTSSDNSLG 139
ADE NG +S + QL + + E +L + NS + L DR ++
Sbjct: 1731 ADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNS--ELLNDRYRKLLLQVESLTT 1788
Query: 140 ALSAARE-SWEYDSGARDLQSPDVQSQSALQKLLEYGGSSLHQQ--AALHKLLTQSPH-- 194
LSA R S + +SG + L+ + + L + + G + H+ AAL L Q+
Sbjct: 1789 ELSAERSFSAKAESGRQQLERQIQELRGRLGEE-DAGARARHKMTIAALESKLAQAEEQL 1847
Query: 195 ---------IGNSVGGSYLELANTL-----HSAALASLKGDIVELNKRLQQTERERDLLE 240
G V + L + L+ + + N R++Q +R+ + E
Sbjct: 1848 EQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAE 1907
Query: 241 KKLAKAQCEQSHLMREHEDV--------QERTTLRYEERITELHSVIAELNKKIDRLQGT 292
++ ++AQ + L RE EDV +E TTLR R L + + +G
Sbjct: 1908 EEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEEGV 1967
Query: 293 TIREEDEYSE 302
EE E ++
Sbjct: 1968 ASDEEAEEAQ 1977
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 80.9 bits (198), Expect = 6e-15
Identities = 171/839 (20%), Positives = 316/839 (37%), Gaps = 108/839 (12%)
Query: 221 DIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITELHSVIA 280
++ EL R+ Q E ER L ++L +A+ E L E E+ + R R +E L V++
Sbjct: 932 EVGELQGRVAQLEEERARLAEQL-RAEAE---LCAEAEETRGRLAARKQE----LELVVS 983
Query: 281 ELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTA 340
EL ++ + + + + E L+ + + + + + + + Q E +
Sbjct: 984 ELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEE 1043
Query: 341 DMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVE 400
D+ D NS+L + LE+ + + S AE + ++ L + I +E
Sbjct: 1044 DLLLLEDQNSKLSKERKLLED-----RLAEFSSQAAEEEEKVKSLNKLRLKYEATIADME 1098
Query: 401 -----------EIEGVLGR------DLYPNLAEERSRWEKELAGLREENESLTAMLCSKE 443
E+E + R +L + E++ R E+ A L + E L A L E
Sbjct: 1099 DRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAE 1158
Query: 444 EELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELS 503
+E + ++RE + L E Q L+S + + + + GEL
Sbjct: 1159 DEGGARAQLLKSLREAQAAL----AEAQEDLESERVARTKAEKQRRDLGEELEALRGELE 1214
Query: 504 TSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSN 563
+ S + A++ SK E L +L++ +
Sbjct: 1215 DTLDSTN------AQQELRSKREQE----------------------VTELKKTLEEETR 1246
Query: 564 IQE--IFQTLYSHGSAISESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERM 621
I E + + HG A+ E + E + R E + L + E + AE
Sbjct: 1247 IHEAAVQELRQRHGQALGE--LAEQLEQARRGKGAWEKTR-----LALEAEVSELRAELS 1299
Query: 622 SMLVGKYESNATALRLALQYSEQCIEAYELLLALAESEQSLILGQFRAAGVGSSPGDQSG 681
S+ + E RL LQ E A + A AE+ + L Q V + +
Sbjct: 1300 SLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAES 1359
Query: 682 -----DENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNSH 736
+ ++ + HD ++ + +A L AG Q E ++
Sbjct: 1360 KTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARER 1419
Query: 737 TSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDVKPRG 796
TA + +E+ + E+ + R A + + + + D RG
Sbjct: 1420 AGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERG 1479
Query: 797 --------DSQRLDLENAVLMQELMAMKEE-----MAELKAQLYLLEKEKKALELKLSTR 843
D +DLE + + K+ +AE KA + +E++ E + R
Sbjct: 1480 RRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGRER 1539
Query: 844 EAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSS---GSKDKPGKECAD------AASPA 894
EA+ + +E + E E+ E++ R+L + SKD GK + A A
Sbjct: 1540 EARALSLTRALEE-EQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQA 1598
Query: 895 LSLAELRTTCSENELAAEFTNAIRREKKLKARVQELVSALERLTKSSEIRHQQ------S 948
+ + T E+EL A +R E ++A + L+ ++ E R +Q
Sbjct: 1599 ANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRD 1658
Query: 949 AEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMMAMVERHETQVRMLKQRIALLEE 1007
AE D +R L A A+KK + +L++L++QM + + E V+ L++ A ++E
Sbjct: 1659 AEVERDEERKQRTLAVA---ARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKE 1714
Score = 80.1 bits (196), Expect = 1e-14
Identities = 188/899 (20%), Positives = 337/899 (37%), Gaps = 132/899 (14%)
Query: 204 LELANTLHSAALASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQ-- 261
L+L A + + D++ L + + +ER LLE +LA+ S E E V+
Sbjct: 1027 LQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEF---SSQAAEEEEKVKSL 1083
Query: 262 ERTTLRYEERITEL----------HSVIAELNKKID----RLQGTTIREEDEYSELRSEL 307
+ L+YE I ++ + +L +++D LQ + ++ ELR++L
Sbjct: 1084 NKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQL 1143
Query: 308 SQSQHEVNED-SRSMDQD----QTSVSIPENQSTMVTADMDNCS-------------DLN 349
+ + E+ +R+ D+ Q S+ E Q+ + A D S DL
Sbjct: 1144 GRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLG 1203
Query: 350 SELQRVLTGLENVVCGRK-----KSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEG 404
EL+ + LE+ + +S V E+ + +E+ T E A++ + + G
Sbjct: 1204 EELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHE---AAVQELRQRHG 1260
Query: 405 VLGRDLYPNLAEER---SRWEK-------ELAGLREENESLTAMLCSKEEELNRTKATMN 454
+L L + R WEK E++ LR E SL E+ R + +
Sbjct: 1261 QALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQ 1320
Query: 455 AIREERDRLRRRVRELQTRLQSVQATGPSSPGRLT-STNRPINPSTGELSTSSSSNDIPI 513
++ R E +LQ QA + G L + ++ I S ST + +D
Sbjct: 1321 EVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHD--- 1377
Query: 514 AKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLA-------------HSLQD 560
A+ + +TR++ + R V E + G+ + E A L +
Sbjct: 1378 ---AQELLQEETRAKLALGSR-VRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSE 1433
Query: 561 CSNIQEIFQTLYSHGSAISESKIREFEVETERLNSR---IEHLKSQNDLLTITLEECKSN 617
QE G RE E T+RL + ++ L+ L L++ +
Sbjct: 1434 WRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMD 1493
Query: 618 AERMSMLVGKYESNATALRLALQYSEQCIEAYELLLALAESEQSLILGQFRAAGVGSSPG 677
E+ LV E L + + L A+ E E++ G+ R A S
Sbjct: 1494 LEQQRQLVSTLEKKQRKFDQLLAEEKAAV-----LRAVEERERAEAEGREREARALS--- 1545
Query: 678 DQSGDENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNSHT 737
+T+ L+ + R+ E +AL +L+ V G SV E +
Sbjct: 1546 -------LTRALEEEQEAREELERQNRALRAELEALLSSKDDV-GKSVHELERACRVAEQ 1597
Query: 738 STTSSTASSCDTE----FTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDPLS---Y 790
+ A + E ++ + RL+ +Q LK E L+
Sbjct: 1598 AANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLR 1657
Query: 791 DVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAY 850
D + D +R AV ++ ++ E+ ELKAQ+ + K+ +L +AQ
Sbjct: 1658 DAEVERDEERKQRTLAVAARK--KLEGELEELKAQMASAGQGKEEAVKQLRKMQAQ---- 1711
Query: 851 LVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKEC----ADAASPALSLAELRTTCSE 906
++ L EVEE + R S K G E A A +
Sbjct: 1712 ---MKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDR 1768
Query: 907 NELAAEFTN------AIRREKK-LKARVQELVSALERLTKSSEIRHQQ------SAEFVN 953
+E+A E N AI EK+ L+ R+ +L LE +SE+ + + E +
Sbjct: 1769 DEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLT 1828
Query: 954 DLKRANSNLVAAYEKAKKKHQNKLKKLESQM----MAMVERHETQVRMLKQRIALLEEE 1008
A + A E +++ + ++++L ++ RH+ + L+ ++A EE+
Sbjct: 1829 TELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQ 1887
Score = 61.2 bits (147), Expect = 5e-09
Identities = 202/1001 (20%), Positives = 361/1001 (36%), Gaps = 153/1001 (15%)
Query: 83 DENGKISFQDFTRCRMQLVREIRKEEVDLSAKSDNSCTK---KLRDRIASWPTSSDNSLG 139
D+N K+S + + + E R E A + K KLR + + ++ L
Sbjct: 1050 DQNSKLS-------KERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLR 1102
Query: 140 ALSAARESWE-----YDSGARDLQSPDVQSQSALQKL-LEYGGSSLHQQAALHKLLTQSP 193
R+ E D + +LQ V+ Q ++L + G QAAL +
Sbjct: 1103 KEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALAR------ 1156
Query: 194 HIGNSVGGSYLELANTLHSA--ALASLKGDIV-ELNKRLQQTERERDL----------LE 240
GG+ +L +L A ALA + D+ E R + ++ RDL LE
Sbjct: 1157 --AEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELE 1214
Query: 241 KKLAKAQCEQSHLMREHEDVQE-RTTLRYEERITELH---------SVIAELNKKIDRL- 289
L +Q + ++V E + TL E RI E + EL +++++
Sbjct: 1215 DTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQAR 1274
Query: 290 ------QGTTIREEDEYSELRSELSQSQ---HEVNEDSRSMDQDQTSVSIPENQSTMVTA 340
+ T + E E SELR+ELS Q E + R ++ V A
Sbjct: 1275 RGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARA 1334
Query: 341 D-MDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRH-IEQLTTASEHCDLAIKT 398
+ + +EL+ V L + S LS E H ++L LA+
Sbjct: 1335 EAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLAL-- 1392
Query: 399 VEEIEGVLGRDLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKATMNAIRE 458
G R + A R + E+E A L E R + A+
Sbjct: 1393 -----GSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEA 1447
Query: 459 ERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAE 518
+ RR RE + Q + A + RL R + + + ++ + +
Sbjct: 1448 GEEARRRAAREAEALTQRL-AEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEK 1506
Query: 519 RV-KLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSA 577
+ K + +E ++ VL + + E A +L ++E
Sbjct: 1507 KQRKFDQLLAEEKAA---VLRAVEERERAEAEGREREARALSLTRALEE----------- 1552
Query: 578 ISESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALRL 637
+ E E + L + +E L S D + ++ E + + T L
Sbjct: 1553 -EQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELED 1611
Query: 638 ALQYSEQCIEAYELLL-ALAESEQSLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDC- 695
L +E E+ + AL + + G+ D++G+E Q+ K+ D
Sbjct: 1612 ELTAAEDAKLRLEVTVQALKTQHERDLQGR-----------DEAGEERRRQLAKQLRDAE 1660
Query: 696 -----RKTAENAAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTE 750
+ A A KL+G A + Q E + E
Sbjct: 1661 VERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVE 1720
Query: 751 FTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIHI-DPLSYDVKPRGDSQ--RLDLENAV 807
T+ + + +N + +L LE E + + + L+ + R +Q R ++ + V
Sbjct: 1721 ETRTSREEIFS-----QNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEV 1775
Query: 808 LMQEL--MAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAY---LVHIEHLKSEVE 862
L A+ EE +L+ +L LE+E LE + S E Y L+ +E L +E+
Sbjct: 1776 ANGNLSKAAILEEKRQLEGRLGQLEEE---LEEEQSNSELLNDRYRKLLLQVESLTTELS 1832
Query: 863 EQKEQRMRSLSSTSSGSKDKPGKECADAASPALSLAELRTTCSENELAAEFTNAIRREKK 922
+ RS S+ + + + ++ + ELR E + A
Sbjct: 1833 AE-----RSFSAKAESGRQQLERQ----------IQELRGRLGEEDAGA----------- 1866
Query: 923 LKARVQELVSALE-RLTKSSEIRHQQSAEFVNDLKRANSNLVAAYEKAKKK---HQNKLK 978
+AR + ++ALE +L ++ E Q++ E + + LV EK K+ + +
Sbjct: 1867 -RARHKMTIAALESKLAQAEEQLEQETRERI-----LSGKLVRRAEKRLKEVVLQVEEER 1920
Query: 979 KLESQMMAMVERHETQVRMLKQRIALLEEENSRPHTNETSL 1019
++ Q+ +E+ +V+ LK+++ EEE SR L
Sbjct: 1921 RVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRL 1961
Score = 37.0 bits (84), Expect = 0.095
Identities = 24/122 (19%), Positives = 62/122 (50%), Gaps = 5/122 (4%)
Query: 207 ANTLHSAALASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTL 266
A H +A+L+ + + ++L+Q RER L K + +A+ ++ + E+ + R
Sbjct: 1866 ARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEE-ERRVAD 1924
Query: 267 RYEERITELHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQT 326
+ +++ + + + +L ++++ + R + L+ EL +V E + SM+++ T
Sbjct: 1925 QLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQREL----EDVTESAESMNREVT 1980
Query: 327 SV 328
++
Sbjct: 1981 TL 1982
Score = 31.6 bits (70), Expect = 4.0
Identities = 59/250 (23%), Positives = 100/250 (40%), Gaps = 32/250 (12%)
Query: 82 ADE--NGKISFQDFTRCRMQLVREIRKEEVDLSAKSDNSCTKKLRDRIASWPTSSDNSLG 139
ADE NG +S + QL + + E +L + NS + L DR ++
Sbjct: 1772 ADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNS--ELLNDRYRKLLLQVESLTT 1829
Query: 140 ALSAARE-SWEYDSGARDLQSPDVQSQSALQKLLEYGGSSLHQQ--AALHKLLTQSPH-- 194
LSA R S + +SG + L+ + + L + + G + H+ AAL L Q+
Sbjct: 1830 ELSAERSFSAKAESGRQQLERQIQELRGRLGEE-DAGARARHKMTIAALESKLAQAEEQL 1888
Query: 195 ---------IGNSVGGSYLELANTL-----HSAALASLKGDIVELNKRLQQTERERDLLE 240
G V + L + L+ + + N R++Q +R+ + E
Sbjct: 1889 EQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAE 1948
Query: 241 KKLAKAQCEQSHLMREHEDV--------QERTTLRYEERITELHSVIAELNKKIDRLQGT 292
++ ++AQ + L RE EDV +E TTLR R L + + +G
Sbjct: 1949 EEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEEGV 2008
Query: 293 TIREEDEYSE 302
EE E ++
Sbjct: 2009 ASDEEAEEAQ 2018
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 80.9 bits (198), Expect = 6e-15
Identities = 169/903 (18%), Positives = 349/903 (38%), Gaps = 126/903 (13%)
Query: 215 LASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITE 274
+A++K + + L ++E +R LE+K+ E++ L + + + + EER +
Sbjct: 852 MATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEAD-SLADAEERCEQ 910
Query: 275 LHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQ 334
L +L KI + EE+ +EL ++ + + E +E + +D + +++ E +
Sbjct: 911 LIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKE 970
Query: 335 STMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDL 394
+ N L + GL+ + K +L + ++ L + ++
Sbjct: 971 KHATENKVKN-------LTEEMAGLDETIAKLSKEKKALQETH-QQTLDDLQAEEDKVNI 1022
Query: 395 AIKT-------VEEIEGVLGRDLYPNLAEERSRWEKE---------LAGLREENESLTAM 438
K V+++EG L ++ + ER++ + E + + + L
Sbjct: 1023 LTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEK 1082
Query: 439 LCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPS 498
L KE E++ + + + +L+++++ELQ R++ + + + +
Sbjct: 1083 LEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDL 1142
Query: 499 TGELSTSSSSNDIPIAKIAERVKLSKTRSESSSS-----DRPVLGSEISSIGVSSSVAEH 553
+ EL S + + +V+L+K R + L E + A+
Sbjct: 1143 SRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADS 1202
Query: 554 LAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVETERLNSRIEHLKSQNDLLTITLEE 613
+A + N+Q + Q L E + E ++ET+ L+S E + L +
Sbjct: 1203 MAELGEQIDNLQRVKQKL--------EKEKSELKMETDDLSSNAEAISKAKGNLE---KM 1251
Query: 614 CKSNAERMSMLVGKYE------SNATALRLALQ-----YSEQCIEAYELLLALAESEQSL 662
C+S +++S L K E ++ TA R LQ YS Q E L+ L+ S+Q+
Sbjct: 1252 CRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQA- 1310
Query: 663 ILGQFRAAGVGSSPGDQSGDENITQMLKRAHDC-----RKTAENAAKALLMKLDGSCGGA 717
Q ++ + + HDC + E KA L + A
Sbjct: 1311 STQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQR-------A 1363
Query: 718 FAVAGCSVQPW-------------------ESLSSNSHTSTTSSTASSCDTEFTKEDEQR 758
+ A V W + L+ + A + ++ +QR
Sbjct: 1364 LSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQR 1423
Query: 759 LKDYIQQLKND--RAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDL-----ENAVLMQE 811
L++ ++ L D R+ L+ + + D + + K + + + +L E+ L E
Sbjct: 1424 LQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTE 1483
Query: 812 LMAMKEEMAELKAQLYLLEKEKKALELKLS--TREAQEQAYLVH-IEHLKSEVEEQKEQR 868
L +K E QL L +E K L+ ++S T + E +H +E +K +VE++K +
Sbjct: 1484 LFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEI 1543
Query: 869 MRSLSSTSSGSKDKPGK-----------------ECADAASPALSLAELRTTCSE---NE 908
+L + + + GK + A+ L T E +
Sbjct: 1544 QAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQST 1603
Query: 909 LAAEF---TNAIRREKKLKARVQEL---VSALERLTKSSEIRHQQSAEFVNDLKRANSNL 962
L AE +A+R +KK++ + E+ ++ RL S ++ + + + + +
Sbjct: 1604 LDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDA 1663
Query: 963 VAAYEKAK------KKHQNKLKKLESQMMAMVERHETQVRMLKQRIALLEEENSRPHTNE 1016
+ E K ++ N L+ ++ A +E+ E ++ +Q + E HT
Sbjct: 1664 LRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQN 1723
Query: 1017 TSL 1019
TSL
Sbjct: 1724 TSL 1726
Score = 49.3 bits (116), Expect = 2e-05
Identities = 113/612 (18%), Positives = 234/612 (38%), Gaps = 59/612 (9%)
Query: 422 EKELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQ--- 478
EKE+A ++EE + ++EL +++A + E+ L + +LQ ++QS
Sbjct: 849 EKEMATMKEEFQ-------KTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSL 901
Query: 479 ATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLG 538
A +L + E++ + + +I + K + E S+ L
Sbjct: 902 ADAEERCEQLIKNKIQLEAKIKEVTERAEEEE----EINAELTAKKRKLEDECSE---LK 954
Query: 539 SEISSIGVSSSVAEHLAHSLQD-CSNIQEIFQTLYSHGSAISESKIREFEVETERLNSRI 597
+I + ++ + E H+ ++ N+ E L + +S+ K + E +
Sbjct: 955 KDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEK----KALQETHQQTL 1010
Query: 598 EHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYELLLALAE 657
+ L+++ D + I + +++ L G E LR+ L+ +++ +E +L LA
Sbjct: 1011 DDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQE-KKLRMDLERAKRKLEG-DLKLAQES 1068
Query: 658 S----------EQSLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAKALL 707
+ ++ L +F + + S D+ E Q+ K+ + + E + +
Sbjct: 1069 TMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVE--IQLQKKIKELQARIEELGEEIE 1126
Query: 708 MKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLK 767
+ + S L S + A+S E K+ E + + L+
Sbjct: 1127 AERASRAKAEKQRSDLS----RELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLE 1182
Query: 768 NDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLY 827
+ + L H D ++ + + QR+ + L +E +K E +L +
Sbjct: 1183 EATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQK---LEKEKSELKMETDDLSSNAE 1239
Query: 828 LLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKE-----QRMRSLSSTSSGSKDK 882
+ K K LE + E Q + LK++ EEQ+ R+ T +G +
Sbjct: 1240 AISKAKGNLEKMCRSLEDQ-------VSELKTKEEEQQRLINDLTAQRARLQTEAGEYSR 1292
Query: 883 PGKECADAASPALSLAELRTTCSENELAAEFTNAIRREKKLKARVQELVSALERLTKSSE 942
E DA LS ++ +T EL + + + L +Q + L + E
Sbjct: 1293 QLDE-KDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYE 1351
Query: 943 IRHQQSAEFVNDLKRANSNLV---AAYEKAKKKHQNKLKKLESQMMAMVERHETQVRMLK 999
+ AE L +ANS + YE + +L++ + ++ ++ E V +
Sbjct: 1352 EEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVN 1411
Query: 1000 QRIALLEEENSR 1011
+ A LE+ R
Sbjct: 1412 AKCASLEKTKQR 1423
Score = 49.3 bits (116), Expect = 2e-05
Identities = 87/428 (20%), Positives = 179/428 (41%), Gaps = 47/428 (10%)
Query: 215 LASLKGDIVELNKRLQQTERERDLLEKKLAKAQC--EQSHLMREHEDVQE-RTTLRYEER 271
++ L I E K++ + E+ + +E++ + Q E++ EHE+ + R L +
Sbjct: 1512 ISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQV 1571
Query: 272 ITELHSVIAELNKKIDRLQGTTIRE-EDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSI 330
+E+ IAE +++ID+L+ R E S L +E+ +S+++ + M+ D + I
Sbjct: 1572 KSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEI-RSRNDALRVKKKMEGDLNEMEI 1630
Query: 331 PENQSTMVTAD-MDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAE-----VDRHIEQ 384
N + + A+ + N + L+ L++ + G++ L++ E + IE+
Sbjct: 1631 QLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAEIEE 1690
Query: 385 LTTASEHCDLAIKTVEE-----IEGV-LGRDLYPNLAEERSRWEKELAGLREENESLTAM 438
L E + + K E+ E V L +L + + E +++ L+ E E +
Sbjct: 1691 LWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQE 1750
Query: 439 LCSKEEELNR--TKATMNA--IREERD----------RLRRRVRELQTRL-QSVQATGPS 483
+ EE+ + T A M A +++E+D L + V++LQ RL ++ Q
Sbjct: 1751 SRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKG 1810
Query: 484 SPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDR--------- 534
++ + GE+ N + + + + K + + DR
Sbjct: 1811 GKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDL 1870
Query: 535 -PVLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVETERL 593
L +++ S + AE Q +N+ + + + A + I E +V R+
Sbjct: 1871 VDKLQAKVKSYKRQAEEAEE-----QSNANLSKFRKLQHELEEAEERADIAESQVNKLRV 1925
Query: 594 NSRIEHLK 601
SR H K
Sbjct: 1926 KSREVHTK 1933
Score = 48.1 bits (113), Expect = 4e-05
Identities = 56/232 (24%), Positives = 107/232 (46%), Gaps = 31/232 (13%)
Query: 788 LSYDVKPRGDSQRLDLENAVLMQELMAMKEEMA-------ELKAQLYLLEKEKKALELKL 840
L + +KP S + E A + +E K+E+A EL+ ++ L KEK L+L++
Sbjct: 835 LFFKIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQV 894
Query: 841 -----STREAQEQA-----YLVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKECADA 890
S +A+E+ + +E EV E+ E+ +++ + K K EC++
Sbjct: 895 QSEADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEE-EEINAELTAKKRKLEDECSEL 953
Query: 891 ASPALSLAELRTTCSENELAAEFT-NAIRREKKLKARVQELVSALERLTKSSEIRHQQSA 949
+ +L T ++ E T N ++ + A + E ++ L + K+ + HQQ+
Sbjct: 954 KK---DIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQT- 1009
Query: 950 EFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMMAMVERHETQVRMLKQR 1001
++DL +A + V KAK K + ++ LE + E ++RM +R
Sbjct: 1010 --LDDL-QAEEDKVNILTKAKTKLEQQVDDLEGSL-----EQEKKLRMDLER 1053
Score = 42.0 bits (97), Expect = 0.003
Identities = 46/265 (17%), Positives = 115/265 (43%), Gaps = 18/265 (6%)
Query: 218 LKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITELHS 277
L+ +I EL L+QTER R + E++L A E+ L+ T + E +++L S
Sbjct: 1684 LQAEIEELWATLEQTERSRKIAEQELLDAS-ERVQLLHTQNTSLINTKKKLENDVSQLQS 1742
Query: 278 VIAELNKKIDRLQGTTIREEDEYSELRSELSQSQH---EVNEDSRSMDQDQTSVS--IPE 332
+ E+ ++ + + + + + EL + Q + ++++Q + + E
Sbjct: 1743 EVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDE 1802
Query: 333 NQSTMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTASEHC 392
+ + L + ++ + +EN ++ + + + +R +++LT +E
Sbjct: 1803 AEQLALKGGKKQIQKLEARVRELEGEVENEQ--KRNAEAVKGLRKHERRVKELTYQTE-- 1858
Query: 393 DLAIKTVEEIEGVLG-RDLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKA 451
E+ + VL +DL L + ++++ E++ + + + EL +
Sbjct: 1859 -------EDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHELEEAEE 1911
Query: 452 TMNAIREERDRLRRRVRELQTRLQS 476
+ + ++LR + RE+ T++ +
Sbjct: 1912 RADIAESQVNKLRVKSREVHTKISA 1936
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 80.1 bits (196), Expect = 1e-14
Identities = 199/1018 (19%), Positives = 385/1018 (37%), Gaps = 129/1018 (12%)
Query: 69 MEESVAEIMNQLGADENGKISFQDFTRCRMQLVREIRKEEVDLSAKSDNSCT-----KKL 123
M++++ E+ QL +E+ + Q ++++ +E++ L D +C K L
Sbjct: 941 MQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILE---DQNCKLAKEKKLL 997
Query: 124 RDRIASWPTS------SDNSLGALSAARESWEYDSGARDLQSPDVQSQSALQKLLEYGGS 177
DRIA + T+ SL L E+ D R L+ + Q Q + + G
Sbjct: 998 EDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEER-LRREEKQRQELEKTRRKLEGD 1056
Query: 178 SLHQQAALHKLLTQSPHIGNSVGGSYLELANTL----HSAA--------LASLKGDIVEL 225
S + +L Q + + EL L AA + L+ I EL
Sbjct: 1057 STDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISEL 1116
Query: 226 NKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITELHSVIAELNKK 285
+ L+ R+ EK+ E L E ED + T + E R ++ + L K
Sbjct: 1117 QEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELR-SKREQEVNILKKT 1175
Query: 286 IDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTADMDNC 345
++ T E + E+R + SQ+ E+ E Q + + + N +
Sbjct: 1176 LEEEAKT---HEAQIQEMRQKHSQAVEELAE------QLEQTKRVKANLEKAKQTLENER 1226
Query: 346 SDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGV 405
+L +E++ +L G + RKK L +V + E +E D K E++ V
Sbjct: 1227 GELANEVKVLLQGKGDSEHKRKKVEAQLQELQV-KFNEGERVRTELADKVTKLQVELDNV 1285
Query: 406 LG-----RDLYPNLAEERSRWEKELAG----LREENE---SLTAMLCSKEEELNRTKATM 453
G L ++ S E +L L+EEN SL+ L E+E N + +
Sbjct: 1286 TGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQL 1345
Query: 454 NAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPI 513
E + L +++ L ++ ++ S G L + +L S ++
Sbjct: 1346 EEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHE--- 1402
Query: 514 AKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYS 573
K+A KL KT++ L E+ + V +H S + Q+ F L +
Sbjct: 1403 EKVAAYDKLEKTKTR--------LQQELDDLLVD---LDHQRQSACNLEKKQKKFDQLLA 1451
Query: 574 HGSAIS----------ESKIREFEVETERLNSRIEHLKSQ-------NDLLTITLEECKS 616
IS E++ RE E + L +E Q N +E+ S
Sbjct: 1452 EEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMS 1511
Query: 617 NAERMSMLVGKYESNATALRLALQYSEQCIEAYELLLALAESEQ---SLILGQFRAAGVG 673
+ + + V + E + AL ++ + +E E L E + + L +A
Sbjct: 1512 SKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFER 1571
Query: 674 SSPG-DQSGDENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQPWESLS 732
G D+ +E Q++++ + E+ K M AVA +
Sbjct: 1572 DLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSM----------AVAARKKLEMDLKD 1621
Query: 733 SNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDV 792
+H + + + I+QL+ +A +K M EL+
Sbjct: 1622 LEAHIDSANKNRD---------------EAIKQLRKLQAQMKDCMRELDDTRASREEILA 1666
Query: 793 KPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLV 852
+ + + ++L A E++ ++EE+A + ++E+ L +++ + L
Sbjct: 1667 QAKENEKKLKSMEA----EMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALE 1722
Query: 853 HIEHLKSEVEEQKEQRMRSLSSTS-SGSKDKPGKECADAASPALSLAELRTTCSENELAA 911
L++ + + +E+ +T + K D + L+L R+ +NE A
Sbjct: 1723 EKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLE--RSHAQKNENAR 1780
Query: 912 EFTNAIRREKKLKARVQELVSALERLTKSS----EIRHQQSAEFVNDLKRANSNLVAAYE 967
+ R+ K+LK ++QE+ ++ K+S E + Q E +++ +
Sbjct: 1781 Q--QLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVR 1838
Query: 968 KAKKKHQNKLKKLE------SQMMAMVERHETQVRMLKQRIALLEEENSRPHTNETSL 1019
+ +KK ++ L +++ Q ++ T+++ LK+++ EEE R + + L
Sbjct: 1839 RTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKL 1896
Score = 78.6 bits (192), Expect = 3e-14
Identities = 170/894 (19%), Positives = 344/894 (38%), Gaps = 133/894 (14%)
Query: 234 RERDLL-EKKLAKAQCEQSHLMRE----HEDVQERTTL--RYEERITELHSVIAELNKKI 286
RE+ L E +L + + QS LM E E +Q T L EE L + EL +
Sbjct: 858 REKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEIC 917
Query: 287 DRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTADMDNCS 346
L+ EE+ L++E + Q + E +++++++ + + A +
Sbjct: 918 HDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLE 977
Query: 347 -------DLNSELQRVLTGLENVVCG-----RKKSSCSLSVAEV-DRHIEQLTTASEHCD 393
D N +L + LE+ + ++ S S+A++ ++H +T E
Sbjct: 978 EEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLR 1037
Query: 394 LAIKTVEEIEGVLGRDLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKATM 453
K +E+E + L + + ++A L+ + L L KEEEL A +
Sbjct: 1038 REEKQRQELEKTRRK-----LEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARV 1092
Query: 454 NAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPI 513
+++ +++REL++++ +Q S + EL + + +
Sbjct: 1093 EEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTL 1152
Query: 514 AKIAERVKLSKTRSESSSSDRPVLGSEISSIGVS--------SSVAEHLAHSLQDC---- 561
A + +L R + + + L E + S E LA L+
Sbjct: 1153 DSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVK 1212
Query: 562 SNIQEIFQTLYS-------------HGSAISESKIREFEVETERLNSRIEHLKSQNDLLT 608
+N+++ QTL + G SE K ++ E + + L + + L
Sbjct: 1213 ANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELA 1272
Query: 609 ITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYELLLALAESEQSLIL---- 664
+ + + + ++ L+ + +S ++ L E ++ + LL E+ Q L L
Sbjct: 1273 DKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQ-EENRQKLSLSTKL 1331
Query: 665 -------GQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAENA------AKALLMKLD 711
FR + ++ I + + D +K E++ A+ + KL
Sbjct: 1332 KQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQ 1391
Query: 712 GSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKED----EQRLKDYIQQL- 766
G V ++ L D + ++ E++ K + Q L
Sbjct: 1392 KDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLA 1451
Query: 767 -----------KNDRAAVKLTMLELESIHI-DPLSYDVKPRGDSQRLDLENAVLMQELMA 814
+ DRA + E +++ + L ++ + + +RL+ + M++LM+
Sbjct: 1452 EEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMS 1511
Query: 815 MKEEMAELKAQLYLLEKEKKAL-----ELKLSTREAQEQAYLVHIEHLKSEV-------- 861
K+++ + ++ LEK K+AL E+K E +++ L+ EV
Sbjct: 1512 SKDDVGK---SVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQ 1568
Query: 862 ------------EEQKEQRMRSLSSTSSGSKD-KPGKECADAASPALSLAELRTTCSENE 908
EE+K+Q +R + + +D + + A AA L + +
Sbjct: 1569 FERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDS 1628
Query: 909 LAAEFTNAIRREKKLKARVQELVSALERLTKSSEIRHQQSAEFVNDLKRANSNLV----- 963
AI++ +KL+A++++ + L+ S E Q+ E LK + ++
Sbjct: 1629 ANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEE 1688
Query: 964 -AAYEKAKKKHQNKLKKLESQM--------MAMVERHETQVRMLKQRIALLEEE 1008
AA E+AK++ Q + +L ++ +A+ E+ R L+ RIA LEEE
Sbjct: 1689 LAAAERAKRQAQQERDELADEIANSSGKGALALEEK-----RRLEARIAQLEEE 1737
Score = 70.1 bits (170), Expect = 1e-11
Identities = 179/918 (19%), Positives = 342/918 (37%), Gaps = 149/918 (16%)
Query: 106 KEEVDLSAKSDNSCTKKLRD---RIASWPTSSDNSLGALSAARESWEYDSGARDLQSPDV 162
+E+++ S N K+ RD + + T +++L + +A +E L+S
Sbjct: 1117 QEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQE----------LRSKRE 1166
Query: 163 QSQSALQKLLEYGGSSLHQQAALHKLLTQSPHIGNSVGGSYLELANTLHSAALASLKGDI 222
Q + L+K LE ++A H+ Q +S ELA L
Sbjct: 1167 QEVNILKKTLE-------EEAKTHEAQIQEMRQKHSQAVE--ELAEQLEQTKRVK----- 1212
Query: 223 VELNKRLQQTERERDLLE---KKLAKAQCEQSHLMREHEDVQERTTLRYEE--RI-TELH 276
L K Q E ER L K L + + + H ++ E + +++ E R+ TEL
Sbjct: 1213 ANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELA 1272
Query: 277 SVIAELNKKIDRLQGTTIREED-------EYSELRSELSQSQHEVNEDSRSMDQDQTSVS 329
+ +L ++D + G + + ++S L S+L +Q + E++R T +
Sbjct: 1273 DKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLK 1332
Query: 330 IPENQSTMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTAS 389
E++ ++ + L++ + L V KK +++ + L TA
Sbjct: 1333 QVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKK--------KMEDSVGCLETAE 1384
Query: 390 EHCDLAIKTVEEIEGVLGRD-----LYPNLAEERSRWEKELAGLREENESLTAMLCSKEE 444
E + K +++EG+ R Y L + ++R ++EL L + + C+ E+
Sbjct: 1385 E---VKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEK 1441
Query: 445 E-------LNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINP 497
+ L K EERDR RE +T+ S+ + + R
Sbjct: 1442 KQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQ 1501
Query: 498 STGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEISS-IGVSSSVAEHLAH 556
E+ SS D + K ++ SK E + E+ + + L
Sbjct: 1502 FRTEMEDLMSSKD-DVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEV 1560
Query: 557 SLQDCSNIQEIFQTLYSHGSAISESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKS 616
+LQ ++ F+ SE K ++ + + + +E + Q + ++ +
Sbjct: 1561 NLQA---MKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEM 1617
Query: 617 NAERMSMLVGKYESNATA----LRLALQYSEQCIEAYELLLALAESEQSLILGQFRAAGV 672
+ + + + N LR + C+ EL A E+ L + +
Sbjct: 1618 DLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMR--ELDDTRASREEILAQAKENEKKL 1675
Query: 673 GSSPGDQSGDENITQMLKRAHDCRKTAENAAKALLMKLDGSCG-GAFAVAGCSVQPWESL 731
S + + + L A ++ A+ L ++ S G GA A+
Sbjct: 1676 KSMEAEMI---QLQEELAAAERAKRQAQQERDELADEIANSSGKGALALE---------- 1722
Query: 732 SSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIHID---PL 788
A E E+EQ + I NDR +K L+++ I+ D
Sbjct: 1723 ------EKRRLEARIAQLEEELEEEQGNTELI----NDR--LKKANLQIDQINTDLNLER 1770
Query: 789 SYDVKPRGDSQRLDLENAVLMQELM---------------AMKEEMAELKAQLYLLEKEK 833
S+ K Q+L+ +N L +L A++ ++A+L+ QL KE+
Sbjct: 1771 SHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKER 1830
Query: 834 KALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKECADAASP 893
+A ++ E + + L+ ++ + E+ K+Q AD AS
Sbjct: 1831 QAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQ--------------------ADKAST 1870
Query: 894 ALSLAELRTTCSENELAAEFTNAIRREKKLKARVQELVSALERLTKSSEIRHQQSAEFVN 953
L +L+ E E A+ NA RR +L LE T++++ +++ + N
Sbjct: 1871 RLK--QLKRQLEEAEEEAQRANASRR---------KLQRELEDATETADAMNREVSSLKN 1919
Query: 954 DLKRANSNLVAAYEKAKK 971
L+R + V A+K
Sbjct: 1920 KLRRGDLPFVVPRRMARK 1937
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 80.1 bits (196), Expect = 1e-14
Identities = 150/811 (18%), Positives = 322/811 (39%), Gaps = 97/811 (11%)
Query: 218 LKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITELHS 277
++G++ E+ ++ QQ E+++L ++L ++ L E E+++ R + +E L
Sbjct: 871 VEGELEEMERKHQQLLEEKNILAEQLQA----ETELFAEAEEMRARLAAKKQE----LEE 922
Query: 278 VIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTM 337
++ +L +++ + ++E ++++ + + +++E+ + + Q E +
Sbjct: 923 ILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKK 982
Query: 338 VTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDLAIK 397
+ ++ D NS+ + +E+ + + CS +AE + + L ++ I
Sbjct: 983 MEEEILLLEDQNSKFIKEKKLMEDRI-----AECSSQLAEEEEKAKNLAKIRNKQEVMIS 1037
Query: 398 TVEEI---EGVLGRDLYP---NLAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKA 451
+EE E ++L L E + + ++A L+ + + L L KEEEL A
Sbjct: 1038 DLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALA 1097
Query: 452 TMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDI 511
+ ++ + VRELQ ++ +Q
Sbjct: 1098 RGDDETLHKNNALKVVRELQAQIAELQ--------------------------------- 1124
Query: 512 PIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQTL 571
+ E K S+ ++E D L E+ E L L+D + Q L
Sbjct: 1125 ---EDFESEKASRNKAEKQKRD---LSEEL----------EALKTELEDTLDTTAAQQEL 1168
Query: 572 YSHGSAISESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKYESN 631
+ + E ET+ ++I+ ++ ++ LEE E+ E N
Sbjct: 1169 RTKREQEVAELKKALEEETKNHEAQIQDMRQRH---ATALEELSEQLEQAKRFKANLEKN 1225
Query: 632 ATALRLALQYSEQCIEAYELLLALAESEQSLILGQFRAAGVGSSPGDQSGDENITQMLKR 691
L + ++ + + A +E ++ + Q + S GD+ ++ ++
Sbjct: 1226 KQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLR----VELAEK 1281
Query: 692 AHDCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQ-PWESLSSNSHTSTTSSTASSCDTE 750
A + +N + L++ G FA S++ + T S
Sbjct: 1282 ASKLQNELDNV--STLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIR 1339
Query: 751 FTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLMQ 810
+E++ L++ ++ + R ++ +L L+S D G + L+ L++
Sbjct: 1340 QLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLK 1399
Query: 811 ELMAMKEEMAELKAQLYLLEKEKKALELKLS--TREAQEQAYLVHIEHLKSEVEEQKEQR 868
+ A+ + + E LEK K L+ +L T + Q + K + +Q
Sbjct: 1400 DAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAE 1459
Query: 869 MRSLSSTSSGSKDKPGKECADAASPALSLAELRTTCSENELAAEFTNAIRREKKLKARVQ 928
+S+S+ + +D+ E + + ALSLA R E EF R+ K+L+A ++
Sbjct: 1460 EKSISARYAEERDRAEAEAREKETKALSLA--RALEEALEAKEEFE---RQNKQLRADME 1514
Query: 929 ELVSA-------LERLTKSSEIRHQQSAEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLE 981
+L+S+ + L KS QQ E L+ L A E AK + + ++ ++
Sbjct: 1515 DLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQAT-EDAKLRLEVNMQAMK 1573
Query: 982 SQ----MMAMVERHETQVRMLKQRIALLEEE 1008
+Q + E++E + R+L +++ LE E
Sbjct: 1574 AQFERDLQTRDEQNEEKKRLLIKQVRELEAE 1604
Score = 77.8 bits (190), Expect = 5e-14
Identities = 184/994 (18%), Positives = 377/994 (37%), Gaps = 137/994 (13%)
Query: 69 MEESVAEIMNQLGADENGKISFQDFTRCRMQLVREIRKEEVDLSAKSDNSCTKKLRDRIA 128
ME+ +AE +QL +E L + K+EV +S L +R+
Sbjct: 1004 MEDRIAECSSQLAEEEEKA----------KNLAKIRNKQEVMIS---------DLEERLK 1044
Query: 129 SWPTSSDNSLGALSAARESWEYDSGARDLQSPDVQSQSALQKL-LEYGGSSLHQQAALHK 187
+ + L A+ + D DLQ + Q+ + +L L+ Q AL +
Sbjct: 1045 K----EEKTRQELEKAKR--KLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALAR 1098
Query: 188 LLTQSPHIGNSVGGSYLELANTLHSAALASLKGDIVELNKRLQQTERERDLLEKKLAKAQ 247
++ H N++ + L+ I EL + + + R+ EK+
Sbjct: 1099 GDDETLHKNNAL-------------KVVRELQAQIAELQEDFESEKASRNKAEKQKRDLS 1145
Query: 248 CEQSHLMREHEDVQERTTLRYEERITELHSVIAELNKKIDRLQGTTIREEDEYSELRSEL 307
E L E ED + T + E R T+ +AEL K ++ T E + ++R
Sbjct: 1146 EELEALKTELEDTLDTTAAQQELR-TKREQEVAELKKALEE---ETKNHEAQIQDMRQRH 1201
Query: 308 SQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLENVVCGRK 367
+ + E++E + + ++ +N+ + T + + ++ LQ+V E+ K
Sbjct: 1202 ATALEELSEQLEQAKRFKANLE--KNKQGLETDNKELACEVKV-LQQVKAESEH-----K 1253
Query: 368 KSSCSLSVAEVDRHIEQLTTAS-EHCDLAIKTVEEIEGVLGRDLYPNLAEERSRWEKELA 426
+ V E+ + + E + A K E++ V L ++ ++ K+ A
Sbjct: 1254 RKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNV--STLLEEAEKKGIKFAKDAA 1311
Query: 427 GLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPG 486
L + + +L + + + + + EE++ L+ + E + ++++ +
Sbjct: 1312 SLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQS 1371
Query: 487 RLTSTNRPINPSTGELSTSSSSNDIPIAK---IAERVKLSKTRSESSSSDRPVLGSEISS 543
+L T + ++ G + + + + +++R++ + + L E+
Sbjct: 1372 QLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDD 1431
Query: 544 IGVSSSVAEHLAHSLQDCSNI---QEIFQTLYSHGSAIS----------ESKIREFEVET 590
+ V L H Q SN+ Q+ F L + +IS E++ RE E +
Sbjct: 1432 LTVD------LDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKA 1485
Query: 591 ERLNSRIEH-------LKSQNDLLTITLEECKSNAERMSMLVGKYESNATAL-------R 636
L +E + QN L +E+ S+ + + V + E + AL R
Sbjct: 1486 LSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMR 1545
Query: 637 LALQYSEQCIEAYELLLALAESEQSLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCR 696
L+ E ++A E E + QF D+ +E ++K+ +
Sbjct: 1546 TQLEELEDELQATEDAKLRLEVNMQAMKAQFER---DLQTRDEQNEEKKRLLIKQVRELE 1602
Query: 697 KTAENAAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDE 756
E+ K A AVA S D E E
Sbjct: 1603 AELEDERKQR----------ALAVA----------------SKKKMEIDLKDLEAQIEAA 1636
Query: 757 QRLKD-YIQQLKNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAM 815
+ +D I+QL+ +A +K ELE + + ++L A E++ +
Sbjct: 1637 NKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEA----EILQL 1692
Query: 816 KEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSST 875
+EE+A + E+E+ L +++ + + A L L++ + Q E+ + S
Sbjct: 1693 QEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIA-QLEEELEEEQSN 1751
Query: 876 SSGSKDKPGKECADAASPALSLAELRTTCSENELAAEFTNAIRREKKLKARVQELVSALE 935
D+ K + LA R+ +++ A + R+ K+LKA++QEL A++
Sbjct: 1752 MELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLE--RQNKELKAKLQELEGAVK 1809
Query: 936 RLTKSSEIRHQQSAEFVNDLKRANSNLVAAYEKAKKKHQNKLKKL----------ESQMM 985
K++ + + + + AA K ++ + KLK++ Q
Sbjct: 1810 SKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYK 1869
Query: 986 AMVERHETQVRMLKQRIALLEEENSRPHTNETSL 1019
+E+ +++ LK+++ EEE +R + + L
Sbjct: 1870 EQMEKANARMKQLKRQLEEAEEEATRANASRRKL 1903
Score = 63.2 bits (152), Expect = 1e-09
Identities = 129/694 (18%), Positives = 271/694 (39%), Gaps = 89/694 (12%)
Query: 216 ASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITEL 275
ASL+ + + + LQ+ R++ L ++ + + E++ L + E+ +E E+++ L
Sbjct: 1311 ASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEE-EEEARKNLEKQVLAL 1369
Query: 276 HSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQS 335
S +A+ KK+D GT E+ +L + + E + + D+ + + + + +
Sbjct: 1370 QSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQEL 1429
Query: 336 TMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDLA 395
+T D+D+ + S L++ + ++ K S+S + A E A
Sbjct: 1430 DDLTVDLDHQRQVASNLEKKQKKFDQLLAEEK----SISARYAEERDRAEAEAREKETKA 1485
Query: 396 IKTVEEIEGVLGRDLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKATMNA 455
+ +E L E + +E++ LR + E L + + ++ + + A
Sbjct: 1486 LSLARALEEAL---------EAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRA 1536
Query: 456 IREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPS-TGELSTSSSSNDIPIA 514
+ ++ + +R ++ EL+ LQ+ + + RL + + +L T N+
Sbjct: 1537 LEQQVEEMRTQLEELEDELQATE----DAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKR 1592
Query: 515 KIAERVKLSKTRSESSSSDRPV-----------LGSEISSIGVSSSVAEHLAHSLQDCSN 563
+ ++V+ + E R + L + I ++ + + L+
Sbjct: 1593 LLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQA 1652
Query: 564 IQEIFQTLYSHGSAISESKIREFEVETERLNS-RIEHLKSQNDLLTITLEECKSNAERMS 622
+ +Q A + + + ++L S E L+ Q +L + E + +AE+
Sbjct: 1653 QMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEEL--ASSERARRHAEQER 1710
Query: 623 MLVGKYESNATALRLALQYSEQCIEA----YELLLALAESEQSLILGQFR--AAGVGSSP 676
+ +N+ + + AL ++ +EA E L +S L+ +FR V +
Sbjct: 1711 DELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLN 1770
Query: 677 GDQSGDENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNSH 736
+ + + + Q A + KA L +L+G+ F
Sbjct: 1771 AELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKF------------------ 1812
Query: 737 TSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAA----VKLTMLELESIHIDPLSYDV 792
+T S+ + + + +EQ ++Q +RAA V+ T +L+ I + D
Sbjct: 1813 ----KATISALEAKIGQLEEQ-----LEQEAKERAAANKLVRRTEKKLKEIFMQ--VEDE 1861
Query: 793 KPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQA--Y 850
+ D + +E A M +LK QL E E++A S R+ Q +
Sbjct: 1862 RRHADQYKEQMEKA---------NARMKQLKRQLE--EAEEEATRANASRRKLQRELDDA 1910
Query: 851 LVHIEHLKSEVEEQKEQRMR----SLSSTSSGSK 880
E L EV K + R S SS+ SG +
Sbjct: 1911 TEANEGLSREVSTLKNRLRRGGPISFSSSRSGRR 1944
Score = 50.1 bits (118), Expect = 1e-05
Identities = 114/606 (18%), Positives = 237/606 (39%), Gaps = 80/606 (13%)
Query: 84 ENGKISFQDFTRCRMQLVREIRKEEVDLSAKSDNSCTKKLRDRIASWPTSSDNSLGALSA 143
E +++ + + +L +E+ VDL + + + + + + + S+ A
Sbjct: 1409 EEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISA-RY 1467
Query: 144 ARESWEYDSGARDLQSPDVQSQSALQKLLE----YGGSSLHQQAALHKLLTQSPHIGNSV 199
A E ++ AR+ ++ + AL++ LE + + +A + L++ +G +V
Sbjct: 1468 AEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNV 1527
Query: 200 GGSYLELANTLHSAALASLKGDIVELNKRLQQTERERDLLEKKLA--KAQCEQSHLMREH 257
LE + + ++ + EL LQ TE + LE + KAQ E+ R+
Sbjct: 1528 --HELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDE 1585
Query: 258 EDVQERTTLRYEERITELHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNED 317
++ +++ L +++ EL + + + K+ + + E + +L +++ + +E
Sbjct: 1586 QNEEKKRLLI--KQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEV 1643
Query: 318 SRSMDQDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAE 377
+ + + Q + + + A D + E ++ L LE + ++ S A
Sbjct: 1644 IKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERAR 1703
Query: 378 VDRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPNLAEERSRWEKELAGLREENESLTA 437
RH EQ RD LA+E + + L +E L A
Sbjct: 1704 --RHAEQ----------------------ERD---ELADEITNSASGKSALLDEKRRLEA 1736
Query: 438 MLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINP 497
+ EEEL ++ M + DR R+ ++ T L + A S+ + + + +
Sbjct: 1737 RIAQLEEELEEEQSNMELL---NDRFRKTTLQVDT-LNAELAAERSAAQKSDNARQQLER 1792
Query: 498 STGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPV--LGSEISSIGVSSSVAEHLA 555
EL + ++ VK SK ++ S+ + + L ++ + A L
Sbjct: 1793 QNKELKAK-------LQELEGAVK-SKFKATISALEAKIGQLEEQLEQEAKERAAANKLV 1844
Query: 556 HSLQDCSNIQEIFQTLYSHGSAISESKIREFEVETERLNSRIEHLKSQNDLLTITLEECK 615
+ ++EIF + +++ + E+ N+R++ LK Q LEE +
Sbjct: 1845 RRTE--KKLKEIFMQVED-----ERRHADQYKEQMEKANARMKQLKRQ-------LEEAE 1890
Query: 616 SNAERMSMLVGKYESNATALRLALQYSEQCIEAYELLLALAESEQSLILGQFRAAGVGSS 675
A R +NA+ +L + + EA E L E S + + R G S
Sbjct: 1891 EEATR---------ANASRRKLQREL-DDATEANEGL----SREVSTLKNRLRRGGPISF 1936
Query: 676 PGDQSG 681
+SG
Sbjct: 1937 SSSRSG 1942
Score = 45.8 bits (107), Expect = 2e-04
Identities = 63/291 (21%), Positives = 127/291 (43%), Gaps = 31/291 (10%)
Query: 753 KEDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLMQEL 812
K+ + ++D +QL + A + L+LE + + + K + L+ +N+ ++E
Sbjct: 946 KKMQAHIQDLEEQLDEEEGARQ--KLQLEKVTAE--AKIKKMEEEILLLEDQNSKFIKEK 1001
Query: 813 MAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSE--VEEQKEQRMR 870
M++ +AE +QL E+E+KA L R QE E LK E ++ E+ R
Sbjct: 1002 KLMEDRIAECSSQL--AEEEEKAKNLA-KIRNKQEVMISDLEERLKKEEKTRQELEKAKR 1058
Query: 871 SLSSTSSGSKDKPGKECADAASPALSLA----ELRTTCSE-NELAAEFTNAIRREKKLKA 925
L ++ +D+ + A L LA EL+ + ++ NA++ ++L+A
Sbjct: 1059 KLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQA 1118
Query: 926 RVQELVSALERLTKSSEIRHQQSAEFVNDLKRANSNL------VAAYEKAKKKHQNKLKK 979
++ EL E S +Q + +L+ + L AA ++ + K + ++ +
Sbjct: 1119 QIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAE 1178
Query: 980 L-----------ESQMMAMVERHETQVRMLKQRIALLEEENSRPHTNETSL 1019
L E+Q+ M +RH T + L +++ + + N+ L
Sbjct: 1179 LKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGL 1229
Score = 37.4 bits (85), Expect = 0.073
Identities = 61/258 (23%), Positives = 114/258 (44%), Gaps = 48/258 (18%)
Query: 792 VKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLE-KEKKALELK----------- 839
VKP R + E +EL+ +KE+ +++ +L +E K ++ LE K
Sbjct: 841 VKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAET 900
Query: 840 --------LSTREAQEQAYLVHIEH-LKSEVEEQKEQRM------RSLSSTSSGSKDKPG 884
+ R A ++ L I H L+S VEE++E+ + + + +++
Sbjct: 901 ELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLD 960
Query: 885 KECADAASPALSL----AELRTTCSENE---LAAEFTNAIRREKKLKARVQELVSAL--- 934
+E + A L L AE + E E L + + I+ +K ++ R+ E S L
Sbjct: 961 EE--EGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEE 1018
Query: 935 -ERLTKSSEIRHQQSAEFVNDLK---RANSNLVAAYEKAKKKHQNKLKKLESQMMAMVER 990
E+ ++IR++Q ++DL+ + EKAK+K + L+ Q+ +
Sbjct: 1019 EEKAKNLAKIRNKQEV-MISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAEL--- 1074
Query: 991 HETQVRMLKQRIALLEEE 1008
+ Q+ LK ++A EEE
Sbjct: 1075 -QAQIDELKLQLAKKEEE 1091
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 80.1 bits (196), Expect = 1e-14
Identities = 217/1026 (21%), Positives = 397/1026 (38%), Gaps = 156/1026 (15%)
Query: 58 NDLLMVCRQLNMEESVAEI-MNQLGADENGKISFQDFTRCRMQLVREIRKEEVDLSAKSD 116
++ L C+ L E+S + +NQL ++ENG +SF+ +RE L +
Sbjct: 293 HETLKQCQDLKTEKSQMDRKINQL-SEENGDLSFK---------LREFASHLQQLQ-DAL 341
Query: 117 NSCTKKLRDRIASWPTSSDNSLGALSAARESWEYDSGARDLQSPDVQSQSALQKLLEYGG 176
N T++ W LSAA + + L+ + Q L +L E+
Sbjct: 342 NELTEEHSKATQEWLEKQAQLEKELSAALQD------KKCLEEKNEILQGKLSQLEEH-- 393
Query: 177 SSLHQQAALHKLLTQSPHIGNSVGGSYLELANTLHSAALASLKGDIVELNKRLQQTERER 236
L +L P V G L+L AA +L + +L R++ E ER
Sbjct: 394 --------LSQLQDNPPQEKGEVLGDVLQLETLKQEAA--TLAANNTQLQARVEMLETER 443
Query: 237 DLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITELHSVIAELNKKIDRLQGTT--- 293
E KL E+ H E+ Q+ ++L IT+L S I+ L++ + L+ +
Sbjct: 444 GQQEAKLL---AERGHF---EEEKQQLSSL-----ITDLQSSISNLSQAKEELEQASQAH 492
Query: 294 -IREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTADMDNCSD-LNSE 351
R + + L SEL+ + + + + + + Q + S L +
Sbjct: 493 GARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQ 552
Query: 352 LQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTASEHC-------DLAIKTVEEIEG 404
++++ + L+ K+ + D H +QL TA+E D A+K +E +E
Sbjct: 553 VEQLSSSLKQKEQQLKEVAEKQEATRQD-HAQQLATAAEEREASLRERDAALKQLEALEK 611
Query: 405 -------VLGRDLY-PNLAEERSRW-----EKELAGLREENESLTAMLCSKEEELNRTKA 451
+L + L N A + ++ ++E A L + E L A + + +E + +A
Sbjct: 612 EKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQA 671
Query: 452 TMNAIR----------EERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGE 501
+ + E++R+ + +LQ +LQ+++ + + G L R + E
Sbjct: 672 QVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEE 731
Query: 502 LSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDC 561
S + E+ K + E + R L + + +G AH +
Sbjct: 732 QQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGE--------AHQAETE 783
Query: 562 SNIQEIFQTLYSHGSAISESK--IREFEVETERL-NSRIEHLKS----QNDLLTITLEEC 614
+E+ + + + +A SE + ++E ER +S+ E + Q L+T+ EEC
Sbjct: 784 VLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLK-EEC 842
Query: 615 KSNAERMSMLVGKYESNATALRLALQYSEQCIEAYELLLALAESEQSLILGQFRAAGVGS 674
+ R + K + LQ S Q E EL LA + Q + + RA +
Sbjct: 843 EK--ARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLAD 900
Query: 675 SPGD-----QSGDENITQMLKRAHDCRKTAENAAKALLMK-----------LDGSCGGAF 718
+ + + ++ + E A++ L+ + L+ G F
Sbjct: 901 DLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQF 960
Query: 719 AVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTML 778
++Q E + A+ +++ +++E+ + +R +LT
Sbjct: 961 CSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERG--------QQEREVARLTQ- 1011
Query: 779 ELESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKALEL 838
E D L+ + R + + + L+NA+ Q + E A L+ L EK+ +
Sbjct: 1012 ERGRAQAD-LALEKAARAELE-MRLQNALNEQRV-----EFATLQEALAHALTEKEGKDQ 1064
Query: 839 KLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKECADAASPA---- 894
+L+ E A + +E L+ V++ KEQ + +SGS + E A P
Sbjct: 1065 ELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQ--SEAAGRTEPTGPKL 1122
Query: 895 ----LSLAELRTTC-SENELAAEFTNAIRREKKLKARVQELVSALERL-----TKSSEIR 944
+++L C + E A ++ E+ +A E SALE L K+ E+
Sbjct: 1123 EALRAEVSKLEQQCQKQQEQADSLERSLEAERASRA---ERDSALETLQGQLEEKAQELG 1179
Query: 945 HQQSAEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMMAMVERHETQVRMLKQRIAL 1004
H QSA L A L AA+ + H K E + A V R + I+
Sbjct: 1180 HSQSA-----LASAQREL-AAFRTKVQDH----SKAEDEWKAQVARGRQEAERKNSLISS 1229
Query: 1005 LEEENS 1010
LEEE S
Sbjct: 1230 LEEEVS 1235
Score = 75.9 bits (185), Expect = 2e-13
Identities = 166/813 (20%), Positives = 301/813 (37%), Gaps = 139/813 (17%)
Query: 208 NTLHSAALASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLR 267
N S + AS GDI LQ + + L+K+LA R + D E
Sbjct: 194 NNFLSGSPASPMGDI------LQTPQFQMRRLKKQLADE--------RSNRDELELELAE 239
Query: 268 YEERITELHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTS 327
+ +TE + IA + ++IDRL + E+ S L + + + NE S +M +T
Sbjct: 240 NRKLLTEKDAQIAMMQQRIDRL--ALLNEKQAASPLEPKELEELRDKNE-SLTMRLHET- 295
Query: 328 VSIPENQSTMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTT 387
+ C DL +E +++DR I QL
Sbjct: 296 --------------LKQCQDLKTE-----------------------KSQMDRKINQL-- 316
Query: 388 ASEHCDLAIKTVEEIEGVLGRDLYPNLAEERSRWEKELAGLREENESLTAMLCSK----E 443
+ E+ DL+ K E A + + L L EE+ T K E
Sbjct: 317 SEENGDLSFKLRE-------------FASHLQQLQDALNELTEEHSKATQEWLEKQAQLE 363
Query: 444 EELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELS 503
+EL+ + E+ + L+ ++ +L+ L +Q P G + + E +
Sbjct: 364 KELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAA 423
Query: 504 TSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSN 563
T +++N ++ RV++ +T E + +L H Q S+
Sbjct: 424 TLAANN----TQLQARVEMLET--ERGQQEAKLLAER-----------GHFEEEKQQLSS 466
Query: 564 IQEIFQTLYSHGSAISESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERMSM 623
+ Q+ S+ S E + + RL +++ L S+ L T+++ + ++
Sbjct: 467 LITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQ---QDQELAG 523
Query: 624 LVGKYESNATALRLALQYSEQCIEAY-----ELLLALAESEQSLILGQFRAAGVGSSPGD 678
L + + L LQ EQ + +L +L + EQ L +
Sbjct: 524 LKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQL---------KEVAEKQ 574
Query: 679 QSGDENITQMLKRAHDCRKTA---ENAAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNS 735
++ ++ Q L A + R+ + +AA L L+ + +Q ++
Sbjct: 575 EATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSA 634
Query: 736 HTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDVKPR 795
TS T + + E+ Q + +Q +++ A ++ LEL+ L + +
Sbjct: 635 QTSVTQAQREKAELSRKVEELQACVETARQEQHE-AQAQVAELELQ------LRSEQQKA 687
Query: 796 GDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIE 855
+ +R+ E L ++L A+KE + K LE+EK+ L E Q++ I
Sbjct: 688 TEKERVAQEKDQLQEQLQALKESLKVTKGS---LEEEKRRAADAL---EEQQRC----IS 737
Query: 856 HLKSEVEEQKEQRMRSLSSTSSGSKDKPGKECADAASPALSLA-ELRTTCSENELAAEFT 914
LK+E EQ R +++ G++ +A L A + T ELA
Sbjct: 738 ELKAETRSLVEQHKRERKEL---EEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMA 794
Query: 915 NAIRREKKLKARVQELVSALERLTKSSEIRHQQSAEFVNDL-------KRANSNLVAAYE 967
E + + V+E+ + ER S + Q A F L ++A L A E
Sbjct: 795 AQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKE 854
Query: 968 KAKKKHQNKLKKLESQMMAMVERHETQVRMLKQ 1000
K + ++ Q + E H R L+Q
Sbjct: 855 KVAGIESHSELQISRQQNELAELHANLARALQQ 887
Score = 65.9 bits (159), Expect = 2e-10
Identities = 198/1032 (19%), Positives = 398/1032 (38%), Gaps = 187/1032 (18%)
Query: 124 RDRIASWPTSSDNSLGALSAARESWEYDS---GAR----------DLQSPDVQSQSALQK 170
+ +++S T +S+ LS A+E E S GAR +L + + Q Q+
Sbjct: 461 KQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQE 520
Query: 171 LLEYGGSSLHQQAALHKLLTQSPHIGNSVGGSYLELANTLHSAALASLKGDIVELNKRLQ 230
L + +QA L + L Q + +L+++L LK ++ E + +
Sbjct: 521 LAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKE-QQLK-EVAEKQEATR 578
Query: 231 QT----------ERERDLLEKKLAKAQCE--QSHLMREHEDVQERTTLRYEER------I 272
Q ERE L E+ A Q E + + E +Q++ + E R +
Sbjct: 579 QDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSV 638
Query: 273 TELHSVIAELNKKIDRLQGT--TIREED-----EYSELRSELSQSQHEVNEDSR-SMDQD 324
T+ AEL++K++ LQ T R+E + +EL +L Q + E R + ++D
Sbjct: 639 TQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKD 698
Query: 325 QTSVSIPE-NQSTMVTA-----DMDNCSDLNSELQRVLTGLE----NVVCGRKKSSCSLS 374
Q + +S VT + +D E QR ++ L+ ++V K+ L
Sbjct: 699 QLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELE 758
Query: 375 VAEVDR-----HIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPNLAEERS------RWEK 423
R ++QL A + E E VL R+L +A + + + K
Sbjct: 759 EERAGRKGLEARLQQLGEAHQ---------AETE-VLRRELAEAMAAQHTAESECEQLVK 808
Query: 424 ELAGLREENESLTAMLCSKEEELN---RTKATMNAIREERDRLRRRVRELQTRLQSVQAT 480
E+A RE E S++EE + + ++EE ++ R+ ++E + ++ +++
Sbjct: 809 EVAAWRERYED------SQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESH 862
Query: 481 GPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSE 540
R + ++ + ++ K+A+ + + + ++S + L +
Sbjct: 863 SELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETL 922
Query: 541 ISSIGVSSSVA--EHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVETERLNSRIE 598
+ G A E + + E + +++ ++ E E E++ + +E
Sbjct: 923 VRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELE 982
Query: 599 HLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYELLLALAES 658
L++ +E + ER + + A A LAL+ + + E+ L A +
Sbjct: 983 RLRAALMESQGQQQEERGQQEREVARLTQERGRAQA-DLALEKAARA--ELEMRLQNALN 1039
Query: 659 EQSLILGQFRAAGVGSSPGDQSGDENITQM-------LKRAHDCRKTAENAAKALLMKLD 711
EQ + + A + + D+ + ++ +K + R+T + + L K
Sbjct: 1040 EQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEK 1099
Query: 712 GSCGGAFAVAGCS-----------------------VQPWESLSSNSHTSTTSSTASSCD 748
G+ A + + Q + + + S + AS +
Sbjct: 1100 EHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAE 1159
Query: 749 TEFTKEDEQ-RLKDYIQQLKNDRAAVKLTMLELESIHIDPLSYD-------VKPRGDSQR 800
+ E Q +L++ Q+L + ++A+ EL + + + Q
Sbjct: 1160 RDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQE 1219
Query: 801 LDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSE 860
+ +N+++ +++EE++ L Q+ LEKE ++ ELK + +SE
Sbjct: 1220 AERKNSLIS----SLEEEVSILNRQV--LEKEGESKELK-------------RLVMAESE 1260
Query: 861 VEEQKEQRMRSLSSTSSGSKDKPGKECADAASPALSL---AELRTTCSENELAAEFTNAI 917
++ E+R+R L + ++ + + + + SL AE + SEN L E T+
Sbjct: 1261 KSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASEN-LRQELTSQA 1319
Query: 918 RREKKLKARV---QELVSALERLTKSSEIRHQQSAEFVNDL---KRANSNLVAAYEKAKK 971
R ++L + QE E+ + ++ H + V++L K L A A+K
Sbjct: 1320 ERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEK 1379
Query: 972 KHQNKLKKLES-----------------------QMMAMVERHETQVR-----------M 997
+H+ +L++ + Q +A ER Q+R M
Sbjct: 1380 RHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSM 1439
Query: 998 LKQRIALLEEEN 1009
LK+ LL EEN
Sbjct: 1440 LKKAHGLLAEEN 1451
Score = 53.9 bits (128), Expect = 7e-07
Identities = 160/878 (18%), Positives = 338/878 (38%), Gaps = 102/878 (11%)
Query: 101 VREIRKEEVDLSAKSDNSCTKKLRDRIASWPTSSDNSLGALSAARESWEYDSGARDLQSP 160
+++++++EV +D+ T L++++A+ TS + + + + ++ +R+L
Sbjct: 885 LQQVQEKEVRAQKLADDLST--LQEKMAA--TSKEVARLETLVRKAGEQQETASRELVKE 940
Query: 161 DVQSQSALQKLLE--YGGSSLHQQAALHKLLTQSPHIGNSVGGSYLELANTLHSAALASL 218
++ + LE G QAAL + ++ +GN + L +A + S
Sbjct: 941 PARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNEL--------ERLRAALMESQ 992
Query: 219 KGDIVELNKRLQQTER--------ERDLLEKKLAKAQCEQSHLMREHEDVQERTTLR--Y 268
E ++ ++ R + DL +K A+A+ E +E E TL+
Sbjct: 993 GQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEAL 1052
Query: 269 EERITELHSVIAELNKKIDRLQGTTIREEDEY----SELRSELS--QSQHEVNEDSRSMD 322
+TE EL K+ L+ I+E +E +L+ +L+ + +H ++S
Sbjct: 1053 AHALTEKEGKDQEL-AKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEA 1111
Query: 323 QDQTSVSIPENQSTMVTADM--DNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDR 380
+T + P+ ++ C + + LE R + +L +
Sbjct: 1112 AGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQ--G 1169
Query: 381 HIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPNLAEERSRWEKELAGLREENESLTAMLC 440
+E+ H A+ + + E R + ++ W+ ++A R+E E +++
Sbjct: 1170 QLEEKAQELGHSQSALASAQR-ELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLIS 1228
Query: 441 SKEEE---LNRTKATMNAIREERDRL----RRRVRELQTRLQSVQATGPSSPGRLTSTNR 493
S EEE LNR +E RL + ++L+ RL+ +QA S+ R +
Sbjct: 1229 SLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSS 1288
Query: 494 PINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEI--SSIGVSSSVA 551
+ L + + + + + R+E + + +S+
Sbjct: 1289 ALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQL 1348
Query: 552 EHLAHS--LQDCSNIQEIFQTLYSHGSAISESKIREFEVETERLNS-RIEHLKSQNDLLT 608
EH + + + + + Q L + +A + E E + R E L++Q +L
Sbjct: 1349 EHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQREL-- 1406
Query: 609 ITLEECKSNAERMSMLVGKYESNATALRL-ALQYSEQCIEAYELLLALAESEQSLILGQF 667
+ V + E A LR Y+EQ L++ + L+ +
Sbjct: 1407 -------GELIPLRQKVAEQERTAQQLRAEKASYAEQ--------LSMLKKAHGLLAEEN 1451
Query: 668 RAAGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQP 727
R G ++ G Q + + Q ++ A+ L ++ A + +
Sbjct: 1452 RGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQRE-------AQSTARE 1504
Query: 728 WESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDP 787
E +++ + + + +E+ Q+L ++QL+ ++ ++
Sbjct: 1505 LEVMTAKYEGAKVKVLE---ERQRFQEERQKLTAQVEQLE--------VFQREQTKQVEE 1553
Query: 788 LSYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQE 847
LS K DS D + V Q+L A++ + E + + L+ + L+ +LS +E
Sbjct: 1554 LS---KKLADS---DQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAA 1607
Query: 848 QAYLVHIEHLKSEVEEQKEQ------RMRSLSSTSSGSKDKPGKECADAASPALSLAELR 901
+ Y + +E K+ + +K+Q ++RSL +K+ + A+ L A L+
Sbjct: 1608 EHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAE--AERLGHELQQAGLK 1665
Query: 902 TTCSENELAAEFTNAIRREKKLKARVQELVSALERLTK 939
T +E + T +R L+A+V L L K
Sbjct: 1666 TKEAE-QTCRHLTAQVR---SLEAQVAHADQQLRDLGK 1699
Score = 38.1 bits (87), Expect = 0.043
Identities = 60/301 (19%), Positives = 123/301 (40%), Gaps = 26/301 (8%)
Query: 204 LELANTLHSAALASLKGD----IVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHED 259
L+ A + LA+++ D + E+ + Q T RE +++ K A+ + + ++
Sbjct: 1469 LDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQE 1528
Query: 260 VQERTTLRYEERIT---ELHSVIAELNKKI-DRLQGTTIREED------EYSELRSELSQ 309
+++ T + E+ E + EL+KK+ D Q + ++++ + E + E +
Sbjct: 1529 ERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQR 1588
Query: 310 SQHEVNEDSRSMDQDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLENVVCGRKKS 369
Q ++NE + Q + + + Q D N ELQ L LE + K+
Sbjct: 1589 LQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKEL 1648
Query: 370 SCSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPNLAEERSRWEKELAGLR 429
AE +R +L A A +T + + R L +A + ++L +
Sbjct: 1649 R-----AEAERLGHELQQAGLKTKEAEQTCRHLTAQV-RSLEAQVAHADQQL-RDLGKFQ 1701
Query: 430 EENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLT 489
++L + + +L+ + +++ EE L + ++L Q G S PG
Sbjct: 1702 VATDALKSREPQAKPQLDLSIDSLDLSCEEGTPL-----SITSKLPRTQPDGTSVPGEPA 1756
Query: 490 S 490
S
Sbjct: 1757 S 1757
Score = 37.7 bits (86), Expect = 0.056
Identities = 111/556 (19%), Positives = 212/556 (38%), Gaps = 108/556 (19%)
Query: 97 RMQLVREIRKEEVDLSAKSDNSCTKKLRDRI----ASWPTSSDNSLGALSAARESWEYDS 152
R L +E +E+ +++ ++KL +R+ A ++S + SA RE E S
Sbjct: 1239 RQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALRE--EVQS 1296
Query: 153 GARDLQSPDVQSQSALQKLLEYGGSSLHQQAALHKLLTQSPHIGNSVGGSYLELANTLHS 212
+ + V S++ Q+L + ++ Q S L+L +T
Sbjct: 1297 LREEAEKQRVASENLRQELTSQAERA--EELGQELKAWQEKFFQKEQALSTLQLEHTSTQ 1354
Query: 213 AALASL----------KGDIVELNKR----LQQTERERDLLEKKLAKAQCEQSHL--MRE 256
A ++ L + + KR L+Q+++ L +L +AQ E L +R+
Sbjct: 1355 ALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQ 1414
Query: 257 HEDVQERTTLR-------YEERITEL---HSVIAELNKKI-DRLQGTTIREEDEYSELRS 305
QERT + Y E+++ L H ++AE N+ + +R E E + R
Sbjct: 1415 KVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQARE 1474
Query: 306 ELSQSQHEVNEDSRS-MDQDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLENVVC 364
+ Q V D+ + + + Q + ++TA + +VL +
Sbjct: 1475 KYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAK------VKVLEERQRFQE 1528
Query: 365 GRKKSSCSLSVAEV-----DRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPNLAEERS 419
R+K + + EV + +E+L+ D A K ++ + +
Sbjct: 1529 ERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQ--------KLKAVQAQGG 1580
Query: 420 RWEKELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQA 479
++E L+ + L A L KE+ K M + D +++ +ELQ +L+S++
Sbjct: 1581 ESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLE- 1639
Query: 480 TGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGS 539
+L N+ + AER LG
Sbjct: 1640 -------QLQKENKELRAE------------------AER-----------------LGH 1657
Query: 540 EISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIRE---FEVETERLNSR 596
E+ G+ + AE Q C ++ ++L + A ++ ++R+ F+V T+ L SR
Sbjct: 1658 ELQQAGLKTKEAE------QTCRHLTAQVRSLEAQ-VAHADQQLRDLGKFQVATDALKSR 1710
Query: 597 IEHLKSQNDLLTITLE 612
K Q DL +L+
Sbjct: 1711 EPQAKPQLDLSIDSLD 1726
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 79.3 bits (194), Expect = 2e-14
Identities = 171/897 (19%), Positives = 352/897 (39%), Gaps = 128/897 (14%)
Query: 175 GGSSLH----QQAALHKLLTQSPHIGNSVGGSYLELANTLHSAALASLKGDIVELNKRLQ 230
G SS H Q + L+Q SVG ++ +L H A+ A + ++ ++
Sbjct: 412 GKSSEHLLRPSQVCPQRPLSQERRGKQSVGRTFAKLQGAAHGASCAHSRPPQPNIDGKVL 471
Query: 231 QTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITELHSVIAELNKKIDRLQ 290
+TE + E + +A + +E E TL + R T +
Sbjct: 472 ETEGSQ---ESTVIRAPSLGAQSKKEEEVKTATATLMLQNRATATSPDSGAKKISVKTFP 528
Query: 291 GTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTADMDNCS--DL 348
+ ++ +L + Q E+ + + ++T+ I N + D D+ + +
Sbjct: 529 SAS------NTQATPDLLKGQQELTQQT----NEETAKQILYNYLKEGSTDNDDATKRKV 578
Query: 349 NSELQRVLTGLENVVCGR---KKSSCSLSVAEVDRHIEQLTTAS-EHCDLAIKTVEEIEG 404
N +++ T L++ G +C+ S +EV +EQ + + E +L + E++
Sbjct: 579 NLVFEKIQT-LKSRAAGSAQGNNQACN-STSEVKDLLEQKSKLTIEVAELQRQLQLEVKN 636
Query: 405 VLGRDLYPNLAEERSRWEKELAGLR-------EENESLTAMLCSKEEELNRTKATMNAIR 457
N+ EER R L LR EEN +L L E EL + + ++
Sbjct: 637 ------QQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVK 690
Query: 458 EERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGE-----LSTSSSSNDIP 512
ER++ + +R+LQ +L + L S R + G L D+
Sbjct: 691 MEREQHQTEIRDLQDQLSEMH-------DELDSAKRSEDREKGALIEELLQAKQDLQDLL 743
Query: 513 IAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVS--------SSVAEHLAHSLQDCSNI 564
IAK E+ L + R ++ + L E+SS + + L S+++ +
Sbjct: 744 IAK-EEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKN 802
Query: 565 QEIF---QTLYSHGSAISESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERM 621
E+ A +E +++ + E E+L R E L+ + L +E+ K + +
Sbjct: 803 VEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKA 862
Query: 622 SMLVGKYESNATALRLALQYSEQCIEAYELLLALAESEQSLILGQFRAAGVGSSPGDQSG 681
+ KYE L AL ++ + E E + A E L A G+
Sbjct: 863 KETLKKYEGEIRQLEEALVHARK--EEKEAVSARRALENEL------EAAQGNLSQTTQE 914
Query: 682 DENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTS 741
+ +++ LK E+ K L +L G +++ + ++ ++ +
Sbjct: 915 QKQLSEKLKE--------ESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRT 966
Query: 742 STASSCD--TEFTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQ 799
ST + E+ +++ + L + +QLK LE E K R +
Sbjct: 967 STLELQNQLDEYKEKNRRELAEMQRQLKE-------KTLEAE-----------KSRLTAM 1008
Query: 800 RLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKS 859
++ E ++ +EL + E + LLE+ K LE +L + H++ +S
Sbjct: 1009 KMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKS--------HLKDDRS 1060
Query: 860 EVEEQKEQRMRSLSSTSSGSKDKPGKECADAASPALSLAE----------LRTTCSENEL 909
+ +Q E ++ L ++ +D S +S + L+ + +L
Sbjct: 1061 RLVKQMEDKVSQLEMELEEERNN-----SDLLSERISRSREQMEQLRNELLQERAARQDL 1115
Query: 910 AAEFTNAIRREKKLKARVQELV----SALERLTKSSEIRHQQSAEFVNDLKRANSNLVAA 965
+ + R+ K LK+R+ L S+ E L E R + + + +R +NL +
Sbjct: 1116 ECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLS 1175
Query: 966 YEKAKKKHQNKLKKLESQMMAMVERHE---TQVRMLKQRIALLEEENSRPHTNETSL 1019
+ ++K + + +++ + +++ ++ + +++ +K+++ EEE R +++ L
Sbjct: 1176 NRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKL 1232
Score = 44.3 bits (103), Expect = 6e-04
Identities = 92/458 (20%), Positives = 184/458 (40%), Gaps = 48/458 (10%)
Query: 70 EESVAEIMNQLGADENGKIS--FQDFTRCRMQLVREIRKEEVDLSAKSDNSCTK---KLR 124
+++ E+ +L +EN K+ ++ R QL R+I + D AK+ + K ++R
Sbjct: 816 DQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGD-EAKAKETLKKYEGEIR 874
Query: 125 DRIASWPTSSDNSLGALSAARESWEYDSGARDLQSPDVQSQSALQKLLEYGGSSLHQQAA 184
+ + A+SA R A+ S Q Q L + L+ Q
Sbjct: 875 QLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRR 934
Query: 185 L-HKLLTQSPHIGNSVGGSYLELANTLHSAALASLK-----GDIVELNKRLQQTERERDL 238
L +++ + H+G ++ E+A+ + ++ ++L+ + E N+R + E +R L
Sbjct: 935 LKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRR-ELAEMQRQL 993
Query: 239 LEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITELHSVIAELNKKIDRLQGTTIREED 298
EK L + E+S L T ++ ++ + + + + + D E
Sbjct: 994 KEKTL---EAEKSRL----------TAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQ 1040
Query: 299 EYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLTG 358
+L EL H ++ SR + Q + VS E + + D S+ S + +
Sbjct: 1041 TLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQ 1100
Query: 359 LENVVCGRKKSSCSLSVAEV--DRHIEQLTTASEHCDLAIKTVEE-----IEGVLGRDLY 411
L N + + + L ++ +R + L + H + + ++ +E +E + +L
Sbjct: 1101 LRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIA-ELE 1159
Query: 412 PNL-AEERSRWEKELAGLREENESLTAMLCSKEEELNRT-------------KATMNAIR 457
L +EER R +L+ R E + ++ +E L+ T K +
Sbjct: 1160 DRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAE 1219
Query: 458 EERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPI 495
EE DRL ++LQ L+ G+L S + +
Sbjct: 1220 EEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDL 1257
Score = 41.6 bits (96), Expect = 0.004
Identities = 62/277 (22%), Positives = 121/277 (43%), Gaps = 41/277 (14%)
Query: 91 QDFTRCRMQLVREIRKE-EVDLSAKSD-----NSCTKKLRDRIASWP-------TSSDNS 137
QD + QL+ + K+ E +L AKS + K++ D+++ +SD
Sbjct: 1028 QDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLL 1087
Query: 138 LGALSAARESWEYDSGARDLQSPDVQSQSALQKLLEYGGSSLHQQAALHKLLTQSPHIGN 197
+S +RE E L++ +Q ++A Q L E SL +Q L ++ H+
Sbjct: 1088 SERISRSREQME------QLRNELLQERAARQDL-ECDKISLERQNK--DLKSRIIHLEG 1138
Query: 198 SVGGSYLELANTLHSAALASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREH 257
S S + ++ I EL RL+ ER+R L+ + + + L+ +
Sbjct: 1139 SYRSS--------KEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQV 1190
Query: 258 EDVQERTTLRYEE---RITELHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEV 314
+D T + ++ R+ + + E ++IDRL+ + ++ EL ++ ++H +
Sbjct: 1191 DDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESS---KKKLQRELEEQMDMNEH-L 1246
Query: 315 NEDSRSMDQDQTSVSIPENQSTMVTADMDNCSDLNSE 351
SM +D +P + V DMD+ DL+++
Sbjct: 1247 QGQLNSMKKDLRLKKLP----SKVLDDMDDDDDLSTD 1279
>gi|33946313 ninein isoform 4 [Homo sapiens]
Length = 2096
Score = 78.6 bits (192), Expect = 3e-14
Identities = 208/1034 (20%), Positives = 380/1034 (36%), Gaps = 192/1034 (18%)
Query: 24 SSSSSSDTSSTGEEERMRRLFQTCDGDGDGYISRNDLLMVCRQLNMEESVAEIMNQL--G 81
+S S S EE+++ + + DG+++R L+ +C Q ++ E++ ++
Sbjct: 177 ASQSGSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHN 236
Query: 82 ADENGKISFQDF---------------TRCRMQLVREIRKEEVDLSAK---SDNSCTKKL 123
D +G +S +DF + QL R + + D S + + ++ T +
Sbjct: 237 LDPDGTMSVEDFFYGLFKNGKSLTPSASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTI 296
Query: 124 RDRIASWPTSSDNSLGALSAAR--ESWEYDSGARDLQSPDVQSQSALQKLLEYGGSSLHQ 181
R+ S D+ +G S R ++W Q +++ + K L++ SL
Sbjct: 297 GFRVFS---CLDDGMGHASVERILDTW---------QEEGIENSQEILKALDF---SLDG 341
Query: 182 QAALHKLLTQSPHIGNSVGGSYLELANTLHSAALASLKGDIVELNKRLQQTERERDLLEK 241
L +L ++ L N++H AALAS K +I L +R+ Q RE++ L
Sbjct: 342 NINLTELTL-------ALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRS 394
Query: 242 KLAKAQCEQSHLMREHEDVQERTTLRYEERITELHSVIAELNKKIDRLQGTTIREEDEYS 301
L KA+ +S + E +D R E + +L E ++I L+ +
Sbjct: 395 DLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDE---EYKERIAALK----------N 441
Query: 302 ELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQ-STMVTADMDNCSDLNSELQRVLTGLE 360
ELR E Q + + ++Q+ EN + + S L +EL
Sbjct: 442 ELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENEL-------- 493
Query: 361 NVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGR---DLYPNLAEE 417
+E +E+ +L K +E VL DL P+ AE
Sbjct: 494 ---------------------LENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEF 532
Query: 418 RSRWEKELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSV 477
+ E+ L +R E E +L + +EL + E + R + R L+ L++
Sbjct: 533 FLQ-EERLTQMRNEYERQCRVLQDQVDEL----------QSELEEYRAQGRVLRLPLKN- 580
Query: 478 QATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVL 537
S + + + I P G S P+ E + + E D L
Sbjct: 581 -----SPSEEVEANSGGIEPEHG----LGSEECNPLNMSIEAELVIEQMKEQHHRDICCL 631
Query: 538 GSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVETERLNSRI 597
E+ + L ++ C QE + + + + E +I + + E L +
Sbjct: 632 RLELED--KVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQA 689
Query: 598 EHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYELLLALAE 657
LK + T C+ E+ + V K E T L+ L+ + EL L +
Sbjct: 690 AVLKEAHHEAT-----CRHEEEKKQLQV-KLEEEKTHLQEKLRLQHE----MELKARLTQ 739
Query: 658 SEQSLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTA---------ENAAKALLM 708
++ S + G+ SS + +TQ L++ H + T+ E K LL
Sbjct: 740 AQASF---EREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLE 796
Query: 709 KLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKN 768
K H +TE + Q + +
Sbjct: 797 K--------------------------HQRELQEGREKMETECNRRTSQIEAQFQSDCQK 830
Query: 769 DRAAVKLTMLELESIHIDPL-SYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLY 827
+ + LE + L + R + + + E L QE +E + E
Sbjct: 831 VTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKE------ 884
Query: 828 LLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKE-----QRMRSLSSTSSGSKDK 882
L++EK + RE E+ Y EHL S V E+++ + +R++S T
Sbjct: 885 TLKREKTTSLVLTQEREMLEKTYK---EHLNSMVVERQQLLQDLEDLRNVSETQQSLLSD 941
Query: 883 PGKECADAASPALSLAE--LRTTCSENELAAEFTNAIRREKKLKARVQELVS---ALERL 937
E + L E L + +LA++ + E + QE++S A+E +
Sbjct: 942 QILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQER--QEMMSKLLAMENI 999
Query: 938 TKSS-EIRHQQSAEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMMAMVERH---ET 993
K++ E ++ AE ++ R S + K ++ + L L+S + E +
Sbjct: 1000 HKATCETADRERAEMSTEISRLQSKI-----KEMQQATSPLSMLQSGCQVIGEEEVEGDG 1054
Query: 994 QVRMLKQRIALLEE 1007
+ +L+Q LLEE
Sbjct: 1055 ALSLLQQGEQLLEE 1068
Score = 59.3 bits (142), Expect = 2e-08
Identities = 186/905 (20%), Positives = 323/905 (35%), Gaps = 127/905 (14%)
Query: 88 ISFQDFTRCRMQLVREIRK--EEVDLSAKSDNSCTKKLRDRIASW-PTSSDNSLGALSAA 144
+S ++ +R +L+ K E +L+ K + L ++ P+S++ L
Sbjct: 481 LSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLT 540
Query: 145 RESWEYDSGARDLQSPDVQSQSALQKLLEYGGSSLHQQAALHKLLTQSPHIGNSVGGSYL 204
+ EY+ R LQ + QS L++ G L L SP +
Sbjct: 541 QMRNEYERQCRVLQDQVDELQSELEEYRAQG-------RVLRLPLKNSPSEEVEANSGGI 593
Query: 205 ELANTLHSAALASLKGDI-VELNKRLQQTERERDL------LEKKLAKAQCEQSHLMREH 257
E + L S L I EL + + RD+ LE K+ + + +
Sbjct: 594 EPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSC 653
Query: 258 EDVQERTTLRYEERITELHSVIAELNKKIDRLQG-----------TTIREEDEYSELRSE 306
+ QE R+E L I++L +I LQG T R E+E +L+ +
Sbjct: 654 KKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVK 713
Query: 307 LSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLENVVCGR 366
L + + + E R + + + + Q++ +R GL++
Sbjct: 714 LEEEKTHLQEKLRLQHEMELKARLTQAQAS---------------FEREREGLQSSAWTE 758
Query: 367 KKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPNLAEERSRWEKELA 426
+K L+ H EQLT+ E L EE+ L L E R + E E
Sbjct: 759 EKVR-GLTQELEQFHQEQLTSLVEKHTL---EKEELRKELLEKHQRELQEGREKMETECN 814
Query: 427 GLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPG 486
+ E+ C K T+ +A++ R R+ +++LQ + + ++
Sbjct: 815 RRTSQIEAQFQSDCQKV-----TERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKD 869
Query: 487 RLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGV 546
LT E + + + + ER L KT E ++S+ V
Sbjct: 870 ELTQECAEAQELLKETLKREKTTSLVLTQ--EREMLEKTYKE-----------HLNSMVV 916
Query: 547 SSSVAEHLAHSLQDCSNIQEIFQTLYSHG-SAISESKIREFEVETERL--NSRIEHLKSQ 603
+ L L+D N+ E Q+L S + S RE E L E L SQ
Sbjct: 917 E---RQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQ 973
Query: 604 NDLLTITLEECKSNAERMSMLVGKYE-SNATALRLALQYSEQCIEAYELLLALAESEQSL 662
L + +E + E MS L+ AT + +E E L + E +Q+
Sbjct: 974 R-LERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQAT 1032
Query: 663 -----------ILGQFRAAGVGS----SPGDQSGDEN--ITQMLKRAHDCRKTAENAAKA 705
++G+ G G+ G+Q +EN + L+RAH+ + EN A
Sbjct: 1033 SPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHE-QAVKENVKMA 1091
Query: 706 LLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQ 765
+ + + L SS TEF ++ + ++QQ
Sbjct: 1092 TEIS----------------RLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQ 1135
Query: 766 LKNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLE-NAVLMQELMAMKEEMAELKA 824
+ + L + D +V+ G + ++ V ++E A E +EL+
Sbjct: 1136 NRTKQVEGVTRRHVLSDLEDD----EVRDLGSTGTSSVQRQEVKIEESEASVEGFSELEN 1191
Query: 825 QLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPG 884
E ++ ELK + QEQ + L ++ + E++ L S K
Sbjct: 1192 S---EETRTESWELKNQISQLQEQLMM-----LCADCDRASEKKQDLLFDVSVLKKKLKM 1243
Query: 885 KECADAASPALSL----AELRTTCSENEL---AAEFTNAIRREKKLKARVQELVSALERL 937
E ASP L C + EL + A+ K+L A V L L+++
Sbjct: 1244 LERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKM 1303
Query: 938 TKSSE 942
+ +E
Sbjct: 1304 EEVTE 1308
Score = 55.8 bits (133), Expect = 2e-07
Identities = 173/879 (19%), Positives = 339/879 (38%), Gaps = 173/879 (19%)
Query: 37 EERMRRLFQTCDGDGDGYISRNDLL----MVCRQLNMEESVAEIMNQLGADENGKISFQD 92
+E++ L CD + + DLL ++ ++L M E + E A K+ ++D
Sbjct: 1210 QEQLMMLCADCDRASE---KKQDLLFDVSVLKKKLKMLERIPE------ASPKYKLLYED 1260
Query: 93 FTRCRMQLVREIRKEEV--DLSAKSDNSCTK---KLRDRIASWPTSSDNSLGALSAARES 147
+R L E+R E D + +++ T +L+D + ++ L S +
Sbjct: 1261 VSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFL---SLEKSY 1317
Query: 148 WEYDSGARDLQSPDVQSQSALQKLLEYGGSSLHQQAALHKLLTQSPHIGNSVGGSYLELA 207
E +L ++ Q ++KL E S+ Q+ ++ G+ L+L
Sbjct: 1318 DEVKIENEELNVLVLRLQGKIEKLQE----SVVQRCDCCLWEASLENLEIEPDGNILQLN 1373
Query: 208 NTLHSAA--LASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHED------ 259
TL + S+ I E + Q E LLEK A ++ H++
Sbjct: 1374 QTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQN 1433
Query: 260 ---VQERTTLR-YEERITELHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQH-EV 314
++E TTL ++++ + + IAEL + +LQ T + ++ + L + H E
Sbjct: 1434 QVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEK 1493
Query: 315 NEDSRSMDQD-QTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGL--ENVVCGRKKSSC 371
E+ ++M D Q + S + + ++ + + NS L+ +T L E+ + K +
Sbjct: 1494 EEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTL 1553
Query: 372 SLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPN---------LAEERSRWE 422
+ S E+ + E T + K VE ++ + N L+++ S+ +
Sbjct: 1554 NGSQEEMWQKTE---TVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQ 1610
Query: 423 KELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGP 482
++L +E N+ LT MLC KE+E N+ EER++ + ++E
Sbjct: 1611 EKL---QELNQRLTEMLCQKEKEPG------NSALEEREQEKFNLKE------------- 1648
Query: 483 SSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEIS 542
EL ER K+ + SS L +E+S
Sbjct: 1649 ------------------EL---------------ERCKVQSSTLVSS------LEAELS 1669
Query: 543 SIGVSSSVAEHLAHSLQD----------CSNIQEIFQTLYSHGSAISESKIREFEVETER 592
+ + + + + H L+D C ++ + FQ S + +E ++E E +E
Sbjct: 1670 EVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSD-FQQKISSVLSYNEKLLKEKEALSEE 1728
Query: 593 LNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYELL 652
LNS ++ L +++ LL + K + +E + +L+ L S++ ++ E
Sbjct: 1729 LNSCVDKL-AKSSLLEHRIATMKQEQK-------SWEHQSASLKSQLVASQEKVQNLEDT 1780
Query: 653 LALAESEQSLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAKALLMKLDG 712
+ + S + R Q E + Q + H K +NA
Sbjct: 1781 VQNVNLQMSRMKSDLRVT--------QQEKEALKQEVMSLH---KQLQNA---------- 1819
Query: 713 SCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKE------DEQRLKDYIQQL 766
GG + P S H + D +E + +RL+ +Q
Sbjct: 1820 --GGKSWAPEIATHP-----SGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNT 1872
Query: 767 KNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELK--- 823
K + + + +LES + + P G + E L +E ++E +
Sbjct: 1873 KAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKV 1932
Query: 824 AQLYLLEKEKKALELK---LSTREAQEQAYLVHIEHLKS 859
+Q+ LE+E + + L+ L ++ + L+ ++HL+S
Sbjct: 1933 SQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRS 1971
Score = 52.4 bits (124), Expect = 2e-06
Identities = 186/915 (20%), Positives = 349/915 (38%), Gaps = 160/915 (17%)
Query: 142 SAARESWEYDSGARDLQSPDVQSQSALQKLLEY-------GGSSLHQQAALHKLLTQSPH 194
+A RE E + LQS + Q A L G + AL LL Q
Sbjct: 1006 TADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGAL-SLLQQGEQ 1064
Query: 195 IGNSVGGSYLELANTLHSAALASLK--GDIVELNKRLQQTERERDLLEKKLAKAQCEQS- 251
+ G L L A ++K +I L +RLQ+ LE L + C
Sbjct: 1065 LLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQK-------LEPGLVMSSCLDEP 1117
Query: 252 ------HLMREHEDVQERTTLRYEERITELHSVIAELNKKIDRLQGTTIREEDEYSELRS 305
+ + E ++ + E +T H V+++L R G+T + E++
Sbjct: 1118 ATEFFGNTAEQTEPFLQQNRTKQVEGVTRRH-VLSDLEDDEVRDLGSTGTSSVQRQEVKI 1176
Query: 306 ELSQ------SQHEVNEDSRSMDQD-QTSVSIPENQSTMVTADMDNCSDLNSELQRVLTG 358
E S+ S+ E +E++R+ + + +S + Q M+ AD D S+ +L
Sbjct: 1177 EESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDL------ 1230
Query: 359 LENVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPNLAEER 418
L +V +KK + +E++ AS L + V L +L
Sbjct: 1231 LFDVSVLKKKL----------KMLERIPEASPKYKLLYEDVSRENDCLQEEL----RMME 1276
Query: 419 SRWEKELAGLREENESLTAMLCSKEEELNRTKA---TMNAIREERDRLRRRVRELQTRLQ 475
+R+++ L E N+ LTA + ++EL + + T ++ + D ++ EL +
Sbjct: 1277 TRYDEAL----ENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVL 1332
Query: 476 SVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRP 535
+Q G++ + +S ++ I ++L++T E R
Sbjct: 1333 RLQ-------GKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRS 1385
Query: 536 VLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVETER--L 593
V H +++C + Y G+ K++ E+ +
Sbjct: 1386 V------------------HHVIEECKQ-----ENQYLEGNTQLLEKVKAHEIAWLHGTI 1422
Query: 594 NSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYELLL 653
+ E + QN ++ LEE N + ++ AT L L+ ++ EL
Sbjct: 1423 QTHQERPRVQNQVI---LEE---NTTLLGFQDKHFQHQATIAELELEKTK----LQELTR 1472
Query: 654 ALAESEQSLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKT-AENAAKALLMKLDG 712
L E ++++ Q G +E + M+ HD + T +E K L++ +
Sbjct: 1473 KLKE-RVTILVKQKDVLSHGEK------EEELKAMM---HDLQITCSEMQQKVELLRYES 1522
Query: 713 SCGGAFAVAGCSVQPWESLSSNSHTSTTSSTA-SSCDTEFTKEDEQRLKDYIQQLKNDRA 771
+Q S+ N T+ + S+ ++ + + +K + A
Sbjct: 1523 E----------KLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENA 1572
Query: 772 AVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQL--YLL 829
AV+ M+E I L +Q+LDLEN L Q+ +E++ EL +L L
Sbjct: 1573 AVQ-KMVENLKKQISELKIK------NQQLDLENTELSQKNSQNQEKLQELNQRLTEMLC 1625
Query: 830 EKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSSG-SKDKPGKECA 888
+KEK+ L RE ++ +LK E+E K Q +SS + S+ K
Sbjct: 1626 QKEKEPGNSALEEREQEK-------FNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIV 1678
Query: 889 DAASPAL-----SLAELRTTCSENELAAEFTNAIRREKKL----KARVQELVSALERLTK 939
+ L + +L ++ + ++ + +KL +A +EL S +++L K
Sbjct: 1679 QQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAK 1738
Query: 940 SSEIRH------QQSAEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMMAMVERHET 993
SS + H Q+ + + S LVA+ EK + L+ + + R ++
Sbjct: 1739 SSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQ-----NLEDTVQNVNLQMSRMKS 1793
Query: 994 QVRMLKQRIALLEEE 1008
+R+ +Q L++E
Sbjct: 1794 DLRVTQQEKEALKQE 1808
>gi|33946321 ninein isoform 5 [Homo sapiens]
Length = 2090
Score = 78.6 bits (192), Expect = 3e-14
Identities = 208/1034 (20%), Positives = 380/1034 (36%), Gaps = 192/1034 (18%)
Query: 24 SSSSSSDTSSTGEEERMRRLFQTCDGDGDGYISRNDLLMVCRQLNMEESVAEIMNQL--G 81
+S S S EE+++ + + DG+++R L+ +C Q ++ E++ ++
Sbjct: 171 ASQSGSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHN 230
Query: 82 ADENGKISFQDF---------------TRCRMQLVREIRKEEVDLSAK---SDNSCTKKL 123
D +G +S +DF + QL R + + D S + + ++ T +
Sbjct: 231 LDPDGTMSVEDFFYGLFKNGKSLTPSASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTI 290
Query: 124 RDRIASWPTSSDNSLGALSAAR--ESWEYDSGARDLQSPDVQSQSALQKLLEYGGSSLHQ 181
R+ S D+ +G S R ++W Q +++ + K L++ SL
Sbjct: 291 GFRVFS---CLDDGMGHASVERILDTW---------QEEGIENSQEILKALDF---SLDG 335
Query: 182 QAALHKLLTQSPHIGNSVGGSYLELANTLHSAALASLKGDIVELNKRLQQTERERDLLEK 241
L +L ++ L N++H AALAS K +I L +R+ Q RE++ L
Sbjct: 336 NINLTELTL-------ALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRS 388
Query: 242 KLAKAQCEQSHLMREHEDVQERTTLRYEERITELHSVIAELNKKIDRLQGTTIREEDEYS 301
L KA+ +S + E +D R E + +L E ++I L+ +
Sbjct: 389 DLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDE---EYKERIAALK----------N 435
Query: 302 ELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQ-STMVTADMDNCSDLNSELQRVLTGLE 360
ELR E Q + + ++Q+ EN + + S L +EL
Sbjct: 436 ELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENEL-------- 487
Query: 361 NVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGR---DLYPNLAEE 417
+E +E+ +L K +E VL DL P+ AE
Sbjct: 488 ---------------------LENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEF 526
Query: 418 RSRWEKELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSV 477
+ E+ L +R E E +L + +EL + E + R + R L+ L++
Sbjct: 527 FLQ-EERLTQMRNEYERQCRVLQDQVDEL----------QSELEEYRAQGRVLRLPLKN- 574
Query: 478 QATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVL 537
S + + + I P G S P+ E + + E D L
Sbjct: 575 -----SPSEEVEANSGGIEPEHG----LGSEECNPLNMSIEAELVIEQMKEQHHRDICCL 625
Query: 538 GSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVETERLNSRI 597
E+ + L ++ C QE + + + + E +I + + E L +
Sbjct: 626 RLELED--KVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQA 683
Query: 598 EHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYELLLALAE 657
LK + T C+ E+ + V K E T L+ L+ + EL L +
Sbjct: 684 AVLKEAHHEAT-----CRHEEEKKQLQV-KLEEEKTHLQEKLRLQHE----MELKARLTQ 733
Query: 658 SEQSLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTA---------ENAAKALLM 708
++ S + G+ SS + +TQ L++ H + T+ E K LL
Sbjct: 734 AQASF---EREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLE 790
Query: 709 KLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKN 768
K H +TE + Q + +
Sbjct: 791 K--------------------------HQRELQEGREKMETECNRRTSQIEAQFQSDCQK 824
Query: 769 DRAAVKLTMLELESIHIDPL-SYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLY 827
+ + LE + L + R + + + E L QE +E + E
Sbjct: 825 VTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKE------ 878
Query: 828 LLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKE-----QRMRSLSSTSSGSKDK 882
L++EK + RE E+ Y EHL S V E+++ + +R++S T
Sbjct: 879 TLKREKTTSLVLTQEREMLEKTYK---EHLNSMVVERQQLLQDLEDLRNVSETQQSLLSD 935
Query: 883 PGKECADAASPALSLAE--LRTTCSENELAAEFTNAIRREKKLKARVQELVS---ALERL 937
E + L E L + +LA++ + E + QE++S A+E +
Sbjct: 936 QILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQER--QEMMSKLLAMENI 993
Query: 938 TKSS-EIRHQQSAEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMMAMVERH---ET 993
K++ E ++ AE ++ R S + K ++ + L L+S + E +
Sbjct: 994 HKATCETADRERAEMSTEISRLQSKI-----KEMQQATSPLSMLQSGCQVIGEEEVEGDG 1048
Query: 994 QVRMLKQRIALLEE 1007
+ +L+Q LLEE
Sbjct: 1049 ALSLLQQGEQLLEE 1062
Score = 59.3 bits (142), Expect = 2e-08
Identities = 186/905 (20%), Positives = 323/905 (35%), Gaps = 127/905 (14%)
Query: 88 ISFQDFTRCRMQLVREIRK--EEVDLSAKSDNSCTKKLRDRIASW-PTSSDNSLGALSAA 144
+S ++ +R +L+ K E +L+ K + L ++ P+S++ L
Sbjct: 475 LSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLT 534
Query: 145 RESWEYDSGARDLQSPDVQSQSALQKLLEYGGSSLHQQAALHKLLTQSPHIGNSVGGSYL 204
+ EY+ R LQ + QS L++ G L L SP +
Sbjct: 535 QMRNEYERQCRVLQDQVDELQSELEEYRAQG-------RVLRLPLKNSPSEEVEANSGGI 587
Query: 205 ELANTLHSAALASLKGDI-VELNKRLQQTERERDL------LEKKLAKAQCEQSHLMREH 257
E + L S L I EL + + RD+ LE K+ + + +
Sbjct: 588 EPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSC 647
Query: 258 EDVQERTTLRYEERITELHSVIAELNKKIDRLQG-----------TTIREEDEYSELRSE 306
+ QE R+E L I++L +I LQG T R E+E +L+ +
Sbjct: 648 KKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVK 707
Query: 307 LSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLENVVCGR 366
L + + + E R + + + + Q++ +R GL++
Sbjct: 708 LEEEKTHLQEKLRLQHEMELKARLTQAQAS---------------FEREREGLQSSAWTE 752
Query: 367 KKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPNLAEERSRWEKELA 426
+K L+ H EQLT+ E L EE+ L L E R + E E
Sbjct: 753 EKVR-GLTQELEQFHQEQLTSLVEKHTL---EKEELRKELLEKHQRELQEGREKMETECN 808
Query: 427 GLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPG 486
+ E+ C K T+ +A++ R R+ +++LQ + + ++
Sbjct: 809 RRTSQIEAQFQSDCQKV-----TERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKD 863
Query: 487 RLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGV 546
LT E + + + + ER L KT E ++S+ V
Sbjct: 864 ELTQECAEAQELLKETLKREKTTSLVLTQ--EREMLEKTYKE-----------HLNSMVV 910
Query: 547 SSSVAEHLAHSLQDCSNIQEIFQTLYSHG-SAISESKIREFEVETERL--NSRIEHLKSQ 603
+ L L+D N+ E Q+L S + S RE E L E L SQ
Sbjct: 911 E---RQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQ 967
Query: 604 NDLLTITLEECKSNAERMSMLVGKYE-SNATALRLALQYSEQCIEAYELLLALAESEQSL 662
L + +E + E MS L+ AT + +E E L + E +Q+
Sbjct: 968 R-LERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQAT 1026
Query: 663 -----------ILGQFRAAGVGS----SPGDQSGDEN--ITQMLKRAHDCRKTAENAAKA 705
++G+ G G+ G+Q +EN + L+RAH+ + EN A
Sbjct: 1027 SPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHE-QAVKENVKMA 1085
Query: 706 LLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQ 765
+ + + L SS TEF ++ + ++QQ
Sbjct: 1086 TEIS----------------RLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQ 1129
Query: 766 LKNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLE-NAVLMQELMAMKEEMAELKA 824
+ + L + D +V+ G + ++ V ++E A E +EL+
Sbjct: 1130 NRTKQVEGVTRRHVLSDLEDD----EVRDLGSTGTSSVQRQEVKIEESEASVEGFSELEN 1185
Query: 825 QLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPG 884
E ++ ELK + QEQ + L ++ + E++ L S K
Sbjct: 1186 S---EETRTESWELKNQISQLQEQLMM-----LCADCDRASEKKQDLLFDVSVLKKKLKM 1237
Query: 885 KECADAASPALSL----AELRTTCSENEL---AAEFTNAIRREKKLKARVQELVSALERL 937
E ASP L C + EL + A+ K+L A V L L+++
Sbjct: 1238 LERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKM 1297
Query: 938 TKSSE 942
+ +E
Sbjct: 1298 EEVTE 1302
Score = 55.8 bits (133), Expect = 2e-07
Identities = 173/879 (19%), Positives = 339/879 (38%), Gaps = 173/879 (19%)
Query: 37 EERMRRLFQTCDGDGDGYISRNDLL----MVCRQLNMEESVAEIMNQLGADENGKISFQD 92
+E++ L CD + + DLL ++ ++L M E + E A K+ ++D
Sbjct: 1204 QEQLMMLCADCDRASE---KKQDLLFDVSVLKKKLKMLERIPE------ASPKYKLLYED 1254
Query: 93 FTRCRMQLVREIRKEEV--DLSAKSDNSCTK---KLRDRIASWPTSSDNSLGALSAARES 147
+R L E+R E D + +++ T +L+D + ++ L S +
Sbjct: 1255 VSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFL---SLEKSY 1311
Query: 148 WEYDSGARDLQSPDVQSQSALQKLLEYGGSSLHQQAALHKLLTQSPHIGNSVGGSYLELA 207
E +L ++ Q ++KL E S+ Q+ ++ G+ L+L
Sbjct: 1312 DEVKIENEELNVLVLRLQGKIEKLQE----SVVQRCDCCLWEASLENLEIEPDGNILQLN 1367
Query: 208 NTLHSAA--LASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHED------ 259
TL + S+ I E + Q E LLEK A ++ H++
Sbjct: 1368 QTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQN 1427
Query: 260 ---VQERTTLR-YEERITELHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQH-EV 314
++E TTL ++++ + + IAEL + +LQ T + ++ + L + H E
Sbjct: 1428 QVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEK 1487
Query: 315 NEDSRSMDQD-QTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGL--ENVVCGRKKSSC 371
E+ ++M D Q + S + + ++ + + NS L+ +T L E+ + K +
Sbjct: 1488 EEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTL 1547
Query: 372 SLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPN---------LAEERSRWE 422
+ S E+ + E T + K VE ++ + N L+++ S+ +
Sbjct: 1548 NGSQEEMWQKTE---TVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQ 1604
Query: 423 KELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGP 482
++L +E N+ LT MLC KE+E N+ EER++ + ++E
Sbjct: 1605 EKL---QELNQRLTEMLCQKEKEPG------NSALEEREQEKFNLKE------------- 1642
Query: 483 SSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEIS 542
EL ER K+ + SS L +E+S
Sbjct: 1643 ------------------EL---------------ERCKVQSSTLVSS------LEAELS 1663
Query: 543 SIGVSSSVAEHLAHSLQD----------CSNIQEIFQTLYSHGSAISESKIREFEVETER 592
+ + + + + H L+D C ++ + FQ S + +E ++E E +E
Sbjct: 1664 EVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSD-FQQKISSVLSYNEKLLKEKEALSEE 1722
Query: 593 LNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYELL 652
LNS ++ L +++ LL + K + +E + +L+ L S++ ++ E
Sbjct: 1723 LNSCVDKL-AKSSLLEHRIATMKQEQK-------SWEHQSASLKSQLVASQEKVQNLEDT 1774
Query: 653 LALAESEQSLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAKALLMKLDG 712
+ + S + R Q E + Q + H K +NA
Sbjct: 1775 VQNVNLQMSRMKSDLRVT--------QQEKEALKQEVMSLH---KQLQNA---------- 1813
Query: 713 SCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKE------DEQRLKDYIQQL 766
GG + P S H + D +E + +RL+ +Q
Sbjct: 1814 --GGKSWAPEIATHP-----SGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNT 1866
Query: 767 KNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELK--- 823
K + + + +LES + + P G + E L +E ++E +
Sbjct: 1867 KAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKV 1926
Query: 824 AQLYLLEKEKKALELK---LSTREAQEQAYLVHIEHLKS 859
+Q+ LE+E + + L+ L ++ + L+ ++HL+S
Sbjct: 1927 SQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRS 1965
Score = 52.4 bits (124), Expect = 2e-06
Identities = 186/915 (20%), Positives = 349/915 (38%), Gaps = 160/915 (17%)
Query: 142 SAARESWEYDSGARDLQSPDVQSQSALQKLLEY-------GGSSLHQQAALHKLLTQSPH 194
+A RE E + LQS + Q A L G + AL LL Q
Sbjct: 1000 TADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGAL-SLLQQGEQ 1058
Query: 195 IGNSVGGSYLELANTLHSAALASLK--GDIVELNKRLQQTERERDLLEKKLAKAQCEQS- 251
+ G L L A ++K +I L +RLQ+ LE L + C
Sbjct: 1059 LLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQK-------LEPGLVMSSCLDEP 1111
Query: 252 ------HLMREHEDVQERTTLRYEERITELHSVIAELNKKIDRLQGTTIREEDEYSELRS 305
+ + E ++ + E +T H V+++L R G+T + E++
Sbjct: 1112 ATEFFGNTAEQTEPFLQQNRTKQVEGVTRRH-VLSDLEDDEVRDLGSTGTSSVQRQEVKI 1170
Query: 306 ELSQ------SQHEVNEDSRSMDQD-QTSVSIPENQSTMVTADMDNCSDLNSELQRVLTG 358
E S+ S+ E +E++R+ + + +S + Q M+ AD D S+ +L
Sbjct: 1171 EESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDL------ 1224
Query: 359 LENVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPNLAEER 418
L +V +KK + +E++ AS L + V L +L
Sbjct: 1225 LFDVSVLKKKL----------KMLERIPEASPKYKLLYEDVSRENDCLQEEL----RMME 1270
Query: 419 SRWEKELAGLREENESLTAMLCSKEEELNRTKA---TMNAIREERDRLRRRVRELQTRLQ 475
+R+++ L E N+ LTA + ++EL + + T ++ + D ++ EL +
Sbjct: 1271 TRYDEAL----ENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVL 1326
Query: 476 SVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRP 535
+Q G++ + +S ++ I ++L++T E R
Sbjct: 1327 RLQ-------GKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRS 1379
Query: 536 VLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVETER--L 593
V H +++C + Y G+ K++ E+ +
Sbjct: 1380 V------------------HHVIEECKQ-----ENQYLEGNTQLLEKVKAHEIAWLHGTI 1416
Query: 594 NSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYELLL 653
+ E + QN ++ LEE N + ++ AT L L+ ++ EL
Sbjct: 1417 QTHQERPRVQNQVI---LEE---NTTLLGFQDKHFQHQATIAELELEKTK----LQELTR 1466
Query: 654 ALAESEQSLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKT-AENAAKALLMKLDG 712
L E ++++ Q G +E + M+ HD + T +E K L++ +
Sbjct: 1467 KLKE-RVTILVKQKDVLSHGEK------EEELKAMM---HDLQITCSEMQQKVELLRYES 1516
Query: 713 SCGGAFAVAGCSVQPWESLSSNSHTSTTSSTA-SSCDTEFTKEDEQRLKDYIQQLKNDRA 771
+Q S+ N T+ + S+ ++ + + +K + A
Sbjct: 1517 E----------KLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENA 1566
Query: 772 AVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQL--YLL 829
AV+ M+E I L +Q+LDLEN L Q+ +E++ EL +L L
Sbjct: 1567 AVQ-KMVENLKKQISELKIK------NQQLDLENTELSQKNSQNQEKLQELNQRLTEMLC 1619
Query: 830 EKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSSG-SKDKPGKECA 888
+KEK+ L RE ++ +LK E+E K Q +SS + S+ K
Sbjct: 1620 QKEKEPGNSALEEREQEK-------FNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIV 1672
Query: 889 DAASPAL-----SLAELRTTCSENELAAEFTNAIRREKKL----KARVQELVSALERLTK 939
+ L + +L ++ + ++ + +KL +A +EL S +++L K
Sbjct: 1673 QQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAK 1732
Query: 940 SSEIRH------QQSAEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMMAMVERHET 993
SS + H Q+ + + S LVA+ EK + L+ + + R ++
Sbjct: 1733 SSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQ-----NLEDTVQNVNLQMSRMKS 1787
Query: 994 QVRMLKQRIALLEEE 1008
+R+ +Q L++E
Sbjct: 1788 DLRVTQQEKEALKQE 1802
Score = 37.0 bits (84), Expect = 0.095
Identities = 22/75 (29%), Positives = 40/75 (53%), Gaps = 4/75 (5%)
Query: 37 EERMRRLFQTCDGDGDGYISRNDLLMVCRQLNMEESVAEIMNQLGADEN--GKISFQDFT 94
E R++ LF + D G G + + +L +C L++EE VA ++ Q +N G++ F F
Sbjct: 10 EARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEE-VAPVLQQTLLQDNLLGRVHFDQFK 68
Query: 95 RCRMQLV-REIRKEE 108
+ ++ R + EE
Sbjct: 69 EALILILSRTLSNEE 83
>gi|148536871 ninein isoform 1 [Homo sapiens]
Length = 2046
Score = 78.6 bits (192), Expect = 3e-14
Identities = 208/1034 (20%), Positives = 380/1034 (36%), Gaps = 192/1034 (18%)
Query: 24 SSSSSSDTSSTGEEERMRRLFQTCDGDGDGYISRNDLLMVCRQLNMEESVAEIMNQL--G 81
+S S S EE+++ + + DG+++R L+ +C Q ++ E++ ++
Sbjct: 171 ASQSGSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHN 230
Query: 82 ADENGKISFQDF---------------TRCRMQLVREIRKEEVDLSAK---SDNSCTKKL 123
D +G +S +DF + QL R + + D S + + ++ T +
Sbjct: 231 LDPDGTMSVEDFFYGLFKNGKSLTPSASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTI 290
Query: 124 RDRIASWPTSSDNSLGALSAAR--ESWEYDSGARDLQSPDVQSQSALQKLLEYGGSSLHQ 181
R+ S D+ +G S R ++W Q +++ + K L++ SL
Sbjct: 291 GFRVFS---CLDDGMGHASVERILDTW---------QEEGIENSQEILKALDF---SLDG 335
Query: 182 QAALHKLLTQSPHIGNSVGGSYLELANTLHSAALASLKGDIVELNKRLQQTERERDLLEK 241
L +L ++ L N++H AALAS K +I L +R+ Q RE++ L
Sbjct: 336 NINLTELTL-------ALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRS 388
Query: 242 KLAKAQCEQSHLMREHEDVQERTTLRYEERITELHSVIAELNKKIDRLQGTTIREEDEYS 301
L KA+ +S + E +D R E + +L E ++I L+ +
Sbjct: 389 DLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDE---EYKERIAALK----------N 435
Query: 302 ELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQ-STMVTADMDNCSDLNSELQRVLTGLE 360
ELR E Q + + ++Q+ EN + + S L +EL
Sbjct: 436 ELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENEL-------- 487
Query: 361 NVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGR---DLYPNLAEE 417
+E +E+ +L K +E VL DL P+ AE
Sbjct: 488 ---------------------LENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEF 526
Query: 418 RSRWEKELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSV 477
+ E+ L +R E E +L + +EL + E + R + R L+ L++
Sbjct: 527 FLQ-EERLTQMRNEYERQCRVLQDQVDEL----------QSELEEYRAQGRVLRLPLKN- 574
Query: 478 QATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVL 537
S + + + I P G S P+ E + + E D L
Sbjct: 575 -----SPSEEVEANSGGIEPEHG----LGSEECNPLNMSIEAELVIEQMKEQHHRDICCL 625
Query: 538 GSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVETERLNSRI 597
E+ + L ++ C QE + + + + E +I + + E L +
Sbjct: 626 RLELED--KVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQA 683
Query: 598 EHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYELLLALAE 657
LK + T C+ E+ + V K E T L+ L+ + EL L +
Sbjct: 684 AVLKEAHHEAT-----CRHEEEKKQLQV-KLEEEKTHLQEKLRLQHE----MELKARLTQ 733
Query: 658 SEQSLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTA---------ENAAKALLM 708
++ S + G+ SS + +TQ L++ H + T+ E K LL
Sbjct: 734 AQASF---EREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLE 790
Query: 709 KLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKN 768
K H +TE + Q + +
Sbjct: 791 K--------------------------HQRELQEGREKMETECNRRTSQIEAQFQSDCQK 824
Query: 769 DRAAVKLTMLELESIHIDPL-SYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLY 827
+ + LE + L + R + + + E L QE +E + E
Sbjct: 825 VTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKE------ 878
Query: 828 LLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKE-----QRMRSLSSTSSGSKDK 882
L++EK + RE E+ Y EHL S V E+++ + +R++S T
Sbjct: 879 TLKREKTTSLVLTQEREMLEKTYK---EHLNSMVVERQQLLQDLEDLRNVSETQQSLLSD 935
Query: 883 PGKECADAASPALSLAE--LRTTCSENELAAEFTNAIRREKKLKARVQELVS---ALERL 937
E + L E L + +LA++ + E + QE++S A+E +
Sbjct: 936 QILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQER--QEMMSKLLAMENI 993
Query: 938 TKSS-EIRHQQSAEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMMAMVERH---ET 993
K++ E ++ AE ++ R S + K ++ + L L+S + E +
Sbjct: 994 HKATCETADRERAEMSTEISRLQSKI-----KEMQQATSPLSMLQSGCQVIGEEEVEGDG 1048
Query: 994 QVRMLKQRIALLEE 1007
+ +L+Q LLEE
Sbjct: 1049 ALSLLQQGEQLLEE 1062
Score = 59.3 bits (142), Expect = 2e-08
Identities = 186/905 (20%), Positives = 323/905 (35%), Gaps = 127/905 (14%)
Query: 88 ISFQDFTRCRMQLVREIRK--EEVDLSAKSDNSCTKKLRDRIASW-PTSSDNSLGALSAA 144
+S ++ +R +L+ K E +L+ K + L ++ P+S++ L
Sbjct: 475 LSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLT 534
Query: 145 RESWEYDSGARDLQSPDVQSQSALQKLLEYGGSSLHQQAALHKLLTQSPHIGNSVGGSYL 204
+ EY+ R LQ + QS L++ G L L SP +
Sbjct: 535 QMRNEYERQCRVLQDQVDELQSELEEYRAQG-------RVLRLPLKNSPSEEVEANSGGI 587
Query: 205 ELANTLHSAALASLKGDI-VELNKRLQQTERERDL------LEKKLAKAQCEQSHLMREH 257
E + L S L I EL + + RD+ LE K+ + + +
Sbjct: 588 EPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSC 647
Query: 258 EDVQERTTLRYEERITELHSVIAELNKKIDRLQG-----------TTIREEDEYSELRSE 306
+ QE R+E L I++L +I LQG T R E+E +L+ +
Sbjct: 648 KKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVK 707
Query: 307 LSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLENVVCGR 366
L + + + E R + + + + Q++ +R GL++
Sbjct: 708 LEEEKTHLQEKLRLQHEMELKARLTQAQAS---------------FEREREGLQSSAWTE 752
Query: 367 KKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPNLAEERSRWEKELA 426
+K L+ H EQLT+ E L EE+ L L E R + E E
Sbjct: 753 EKVR-GLTQELEQFHQEQLTSLVEKHTL---EKEELRKELLEKHQRELQEGREKMETECN 808
Query: 427 GLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPG 486
+ E+ C K T+ +A++ R R+ +++LQ + + ++
Sbjct: 809 RRTSQIEAQFQSDCQKV-----TERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKD 863
Query: 487 RLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGV 546
LT E + + + + ER L KT E ++S+ V
Sbjct: 864 ELTQECAEAQELLKETLKREKTTSLVLTQ--EREMLEKTYKE-----------HLNSMVV 910
Query: 547 SSSVAEHLAHSLQDCSNIQEIFQTLYSHG-SAISESKIREFEVETERL--NSRIEHLKSQ 603
+ L L+D N+ E Q+L S + S RE E L E L SQ
Sbjct: 911 E---RQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQ 967
Query: 604 NDLLTITLEECKSNAERMSMLVGKYE-SNATALRLALQYSEQCIEAYELLLALAESEQSL 662
L + +E + E MS L+ AT + +E E L + E +Q+
Sbjct: 968 R-LERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQAT 1026
Query: 663 -----------ILGQFRAAGVGS----SPGDQSGDEN--ITQMLKRAHDCRKTAENAAKA 705
++G+ G G+ G+Q +EN + L+RAH+ + EN A
Sbjct: 1027 SPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHE-QAVKENVKMA 1085
Query: 706 LLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQ 765
+ + + L SS TEF ++ + ++QQ
Sbjct: 1086 TEIS----------------RLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQ 1129
Query: 766 LKNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLE-NAVLMQELMAMKEEMAELKA 824
+ + L + D +V+ G + ++ V ++E A E +EL+
Sbjct: 1130 NRTKQVEGVTRRHVLSDLEDD----EVRDLGSTGTSSVQRQEVKIEESEASVEGFSELEN 1185
Query: 825 QLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPG 884
E ++ ELK + QEQ + L ++ + E++ L S K
Sbjct: 1186 S---EETRTESWELKNQISQLQEQLMM-----LCADCDRASEKKQDLLFDVSVLKKKLKM 1237
Query: 885 KECADAASPALSL----AELRTTCSENEL---AAEFTNAIRREKKLKARVQELVSALERL 937
E ASP L C + EL + A+ K+L A V L L+++
Sbjct: 1238 LERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKM 1297
Query: 938 TKSSE 942
+ +E
Sbjct: 1298 EEVTE 1302
Score = 55.8 bits (133), Expect = 2e-07
Identities = 173/879 (19%), Positives = 339/879 (38%), Gaps = 173/879 (19%)
Query: 37 EERMRRLFQTCDGDGDGYISRNDLL----MVCRQLNMEESVAEIMNQLGADENGKISFQD 92
+E++ L CD + + DLL ++ ++L M E + E A K+ ++D
Sbjct: 1204 QEQLMMLCADCDRASE---KKQDLLFDVSVLKKKLKMLERIPE------ASPKYKLLYED 1254
Query: 93 FTRCRMQLVREIRKEEV--DLSAKSDNSCTK---KLRDRIASWPTSSDNSLGALSAARES 147
+R L E+R E D + +++ T +L+D + ++ L S +
Sbjct: 1255 VSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFL---SLEKSY 1311
Query: 148 WEYDSGARDLQSPDVQSQSALQKLLEYGGSSLHQQAALHKLLTQSPHIGNSVGGSYLELA 207
E +L ++ Q ++KL E S+ Q+ ++ G+ L+L
Sbjct: 1312 DEVKIENEELNVLVLRLQGKIEKLQE----SVVQRCDCCLWEASLENLEIEPDGNILQLN 1367
Query: 208 NTLHSAA--LASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHED------ 259
TL + S+ I E + Q E LLEK A ++ H++
Sbjct: 1368 QTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQN 1427
Query: 260 ---VQERTTLR-YEERITELHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQH-EV 314
++E TTL ++++ + + IAEL + +LQ T + ++ + L + H E
Sbjct: 1428 QVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEK 1487
Query: 315 NEDSRSMDQD-QTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGL--ENVVCGRKKSSC 371
E+ ++M D Q + S + + ++ + + NS L+ +T L E+ + K +
Sbjct: 1488 EEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTL 1547
Query: 372 SLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPN---------LAEERSRWE 422
+ S E+ + E T + K VE ++ + N L+++ S+ +
Sbjct: 1548 NGSQEEMWQKTE---TVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQ 1604
Query: 423 KELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGP 482
++L +E N+ LT MLC KE+E N+ EER++ + ++E
Sbjct: 1605 EKL---QELNQRLTEMLCQKEKEPG------NSALEEREQEKFNLKE------------- 1642
Query: 483 SSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEIS 542
EL ER K+ + SS L +E+S
Sbjct: 1643 ------------------EL---------------ERCKVQSSTLVSS------LEAELS 1663
Query: 543 SIGVSSSVAEHLAHSLQD----------CSNIQEIFQTLYSHGSAISESKIREFEVETER 592
+ + + + + H L+D C ++ + FQ S + +E ++E E +E
Sbjct: 1664 EVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSD-FQQKISSVLSYNEKLLKEKEALSEE 1722
Query: 593 LNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYELL 652
LNS ++ L +++ LL + K + +E + +L+ L S++ ++ E
Sbjct: 1723 LNSCVDKL-AKSSLLEHRIATMKQEQK-------SWEHQSASLKSQLVASQEKVQNLEDT 1774
Query: 653 LALAESEQSLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAKALLMKLDG 712
+ + S + R Q E + Q + H K +NA
Sbjct: 1775 VQNVNLQMSRMKSDLRVT--------QQEKEALKQEVMSLH---KQLQNA---------- 1813
Query: 713 SCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKE------DEQRLKDYIQQL 766
GG + P S H + D +E + +RL+ +Q
Sbjct: 1814 --GGKSWAPEIATHP-----SGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNT 1866
Query: 767 KNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELK--- 823
K + + + +LES + + P G + E L +E ++E +
Sbjct: 1867 KAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKV 1926
Query: 824 AQLYLLEKEKKALELK---LSTREAQEQAYLVHIEHLKS 859
+Q+ LE+E + + L+ L ++ + L+ ++HL+S
Sbjct: 1927 SQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRS 1965
Score = 52.4 bits (124), Expect = 2e-06
Identities = 186/915 (20%), Positives = 349/915 (38%), Gaps = 160/915 (17%)
Query: 142 SAARESWEYDSGARDLQSPDVQSQSALQKLLEY-------GGSSLHQQAALHKLLTQSPH 194
+A RE E + LQS + Q A L G + AL LL Q
Sbjct: 1000 TADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGAL-SLLQQGEQ 1058
Query: 195 IGNSVGGSYLELANTLHSAALASLK--GDIVELNKRLQQTERERDLLEKKLAKAQCEQS- 251
+ G L L A ++K +I L +RLQ+ LE L + C
Sbjct: 1059 LLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQK-------LEPGLVMSSCLDEP 1111
Query: 252 ------HLMREHEDVQERTTLRYEERITELHSVIAELNKKIDRLQGTTIREEDEYSELRS 305
+ + E ++ + E +T H V+++L R G+T + E++
Sbjct: 1112 ATEFFGNTAEQTEPFLQQNRTKQVEGVTRRH-VLSDLEDDEVRDLGSTGTSSVQRQEVKI 1170
Query: 306 ELSQ------SQHEVNEDSRSMDQD-QTSVSIPENQSTMVTADMDNCSDLNSELQRVLTG 358
E S+ S+ E +E++R+ + + +S + Q M+ AD D S+ +L
Sbjct: 1171 EESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDL------ 1224
Query: 359 LENVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPNLAEER 418
L +V +KK + +E++ AS L + V L +L
Sbjct: 1225 LFDVSVLKKKL----------KMLERIPEASPKYKLLYEDVSRENDCLQEEL----RMME 1270
Query: 419 SRWEKELAGLREENESLTAMLCSKEEELNRTKA---TMNAIREERDRLRRRVRELQTRLQ 475
+R+++ L E N+ LTA + ++EL + + T ++ + D ++ EL +
Sbjct: 1271 TRYDEAL----ENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVL 1326
Query: 476 SVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRP 535
+Q G++ + +S ++ I ++L++T E R
Sbjct: 1327 RLQ-------GKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRS 1379
Query: 536 VLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVETER--L 593
V H +++C + Y G+ K++ E+ +
Sbjct: 1380 V------------------HHVIEECKQ-----ENQYLEGNTQLLEKVKAHEIAWLHGTI 1416
Query: 594 NSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYELLL 653
+ E + QN ++ LEE N + ++ AT L L+ ++ EL
Sbjct: 1417 QTHQERPRVQNQVI---LEE---NTTLLGFQDKHFQHQATIAELELEKTK----LQELTR 1466
Query: 654 ALAESEQSLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKT-AENAAKALLMKLDG 712
L E ++++ Q G +E + M+ HD + T +E K L++ +
Sbjct: 1467 KLKE-RVTILVKQKDVLSHGEK------EEELKAMM---HDLQITCSEMQQKVELLRYES 1516
Query: 713 SCGGAFAVAGCSVQPWESLSSNSHTSTTSSTA-SSCDTEFTKEDEQRLKDYIQQLKNDRA 771
+Q S+ N T+ + S+ ++ + + +K + A
Sbjct: 1517 E----------KLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENA 1566
Query: 772 AVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQL--YLL 829
AV+ M+E I L +Q+LDLEN L Q+ +E++ EL +L L
Sbjct: 1567 AVQ-KMVENLKKQISELKIK------NQQLDLENTELSQKNSQNQEKLQELNQRLTEMLC 1619
Query: 830 EKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSSG-SKDKPGKECA 888
+KEK+ L RE ++ +LK E+E K Q +SS + S+ K
Sbjct: 1620 QKEKEPGNSALEEREQEK-------FNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIV 1672
Query: 889 DAASPAL-----SLAELRTTCSENELAAEFTNAIRREKKL----KARVQELVSALERLTK 939
+ L + +L ++ + ++ + +KL +A +EL S +++L K
Sbjct: 1673 QQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAK 1732
Query: 940 SSEIRH------QQSAEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMMAMVERHET 993
SS + H Q+ + + S LVA+ EK + L+ + + R ++
Sbjct: 1733 SSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQ-----NLEDTVQNVNLQMSRMKS 1787
Query: 994 QVRMLKQRIALLEEE 1008
+R+ +Q L++E
Sbjct: 1788 DLRVTQQEKEALKQE 1802
Score = 37.0 bits (84), Expect = 0.095
Identities = 22/75 (29%), Positives = 40/75 (53%), Gaps = 4/75 (5%)
Query: 37 EERMRRLFQTCDGDGDGYISRNDLLMVCRQLNMEESVAEIMNQLGADEN--GKISFQDFT 94
E R++ LF + D G G + + +L +C L++EE VA ++ Q +N G++ F F
Sbjct: 10 EARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEE-VAPVLQQTLLQDNLLGRVHFDQFK 68
Query: 95 RCRMQLV-REIRKEE 108
+ ++ R + EE
Sbjct: 69 EALILILSRTLSNEE 83
>gi|148536869 ninein isoform 2 [Homo sapiens]
Length = 2133
Score = 78.6 bits (192), Expect = 3e-14
Identities = 208/1034 (20%), Positives = 380/1034 (36%), Gaps = 192/1034 (18%)
Query: 24 SSSSSSDTSSTGEEERMRRLFQTCDGDGDGYISRNDLLMVCRQLNMEESVAEIMNQL--G 81
+S S S EE+++ + + DG+++R L+ +C Q ++ E++ ++
Sbjct: 171 ASQSGSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHN 230
Query: 82 ADENGKISFQDF---------------TRCRMQLVREIRKEEVDLSAK---SDNSCTKKL 123
D +G +S +DF + QL R + + D S + + ++ T +
Sbjct: 231 LDPDGTMSVEDFFYGLFKNGKSLTPSASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTI 290
Query: 124 RDRIASWPTSSDNSLGALSAAR--ESWEYDSGARDLQSPDVQSQSALQKLLEYGGSSLHQ 181
R+ S D+ +G S R ++W Q +++ + K L++ SL
Sbjct: 291 GFRVFS---CLDDGMGHASVERILDTW---------QEEGIENSQEILKALDF---SLDG 335
Query: 182 QAALHKLLTQSPHIGNSVGGSYLELANTLHSAALASLKGDIVELNKRLQQTERERDLLEK 241
L +L ++ L N++H AALAS K +I L +R+ Q RE++ L
Sbjct: 336 NINLTELTL-------ALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRS 388
Query: 242 KLAKAQCEQSHLMREHEDVQERTTLRYEERITELHSVIAELNKKIDRLQGTTIREEDEYS 301
L KA+ +S + E +D R E + +L E ++I L+ +
Sbjct: 389 DLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDE---EYKERIAALK----------N 435
Query: 302 ELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQ-STMVTADMDNCSDLNSELQRVLTGLE 360
ELR E Q + + ++Q+ EN + + S L +EL
Sbjct: 436 ELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENEL-------- 487
Query: 361 NVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGR---DLYPNLAEE 417
+E +E+ +L K +E VL DL P+ AE
Sbjct: 488 ---------------------LENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEF 526
Query: 418 RSRWEKELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSV 477
+ E+ L +R E E +L + +EL + E + R + R L+ L++
Sbjct: 527 FLQ-EERLTQMRNEYERQCRVLQDQVDEL----------QSELEEYRAQGRVLRLPLKN- 574
Query: 478 QATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVL 537
S + + + I P G S P+ E + + E D L
Sbjct: 575 -----SPSEEVEANSGGIEPEHG----LGSEECNPLNMSIEAELVIEQMKEQHHRDICCL 625
Query: 538 GSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVETERLNSRI 597
E+ + L ++ C QE + + + + E +I + + E L +
Sbjct: 626 RLELED--KVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQA 683
Query: 598 EHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYELLLALAE 657
LK + T C+ E+ + V K E T L+ L+ + EL L +
Sbjct: 684 AVLKEAHHEAT-----CRHEEEKKQLQV-KLEEEKTHLQEKLRLQHE----MELKARLTQ 733
Query: 658 SEQSLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTA---------ENAAKALLM 708
++ S + G+ SS + +TQ L++ H + T+ E K LL
Sbjct: 734 AQASF---EREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLE 790
Query: 709 KLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKN 768
K H +TE + Q + +
Sbjct: 791 K--------------------------HQRELQEGREKMETECNRRTSQIEAQFQSDCQK 824
Query: 769 DRAAVKLTMLELESIHIDPL-SYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLY 827
+ + LE + L + R + + + E L QE +E + E
Sbjct: 825 VTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKE------ 878
Query: 828 LLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKE-----QRMRSLSSTSSGSKDK 882
L++EK + RE E+ Y EHL S V E+++ + +R++S T
Sbjct: 879 TLKREKTTSLVLTQEREMLEKTYK---EHLNSMVVERQQLLQDLEDLRNVSETQQSLLSD 935
Query: 883 PGKECADAASPALSLAE--LRTTCSENELAAEFTNAIRREKKLKARVQELVS---ALERL 937
E + L E L + +LA++ + E + QE++S A+E +
Sbjct: 936 QILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQER--QEMMSKLLAMENI 993
Query: 938 TKSS-EIRHQQSAEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMMAMVERH---ET 993
K++ E ++ AE ++ R S + K ++ + L L+S + E +
Sbjct: 994 HKATCETADRERAEMSTEISRLQSKI-----KEMQQATSPLSMLQSGCQVIGEEEVEGDG 1048
Query: 994 QVRMLKQRIALLEE 1007
+ +L+Q LLEE
Sbjct: 1049 ALSLLQQGEQLLEE 1062
Score = 59.3 bits (142), Expect = 2e-08
Identities = 186/905 (20%), Positives = 323/905 (35%), Gaps = 127/905 (14%)
Query: 88 ISFQDFTRCRMQLVREIRK--EEVDLSAKSDNSCTKKLRDRIASW-PTSSDNSLGALSAA 144
+S ++ +R +L+ K E +L+ K + L ++ P+S++ L
Sbjct: 475 LSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLT 534
Query: 145 RESWEYDSGARDLQSPDVQSQSALQKLLEYGGSSLHQQAALHKLLTQSPHIGNSVGGSYL 204
+ EY+ R LQ + QS L++ G L L SP +
Sbjct: 535 QMRNEYERQCRVLQDQVDELQSELEEYRAQG-------RVLRLPLKNSPSEEVEANSGGI 587
Query: 205 ELANTLHSAALASLKGDI-VELNKRLQQTERERDL------LEKKLAKAQCEQSHLMREH 257
E + L S L I EL + + RD+ LE K+ + + +
Sbjct: 588 EPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSC 647
Query: 258 EDVQERTTLRYEERITELHSVIAELNKKIDRLQG-----------TTIREEDEYSELRSE 306
+ QE R+E L I++L +I LQG T R E+E +L+ +
Sbjct: 648 KKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVK 707
Query: 307 LSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLENVVCGR 366
L + + + E R + + + + Q++ +R GL++
Sbjct: 708 LEEEKTHLQEKLRLQHEMELKARLTQAQAS---------------FEREREGLQSSAWTE 752
Query: 367 KKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPNLAEERSRWEKELA 426
+K L+ H EQLT+ E L EE+ L L E R + E E
Sbjct: 753 EKVR-GLTQELEQFHQEQLTSLVEKHTL---EKEELRKELLEKHQRELQEGREKMETECN 808
Query: 427 GLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPG 486
+ E+ C K T+ +A++ R R+ +++LQ + + ++
Sbjct: 809 RRTSQIEAQFQSDCQKV-----TERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKD 863
Query: 487 RLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGV 546
LT E + + + + ER L KT E ++S+ V
Sbjct: 864 ELTQECAEAQELLKETLKREKTTSLVLTQ--EREMLEKTYKE-----------HLNSMVV 910
Query: 547 SSSVAEHLAHSLQDCSNIQEIFQTLYSHG-SAISESKIREFEVETERL--NSRIEHLKSQ 603
+ L L+D N+ E Q+L S + S RE E L E L SQ
Sbjct: 911 E---RQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQ 967
Query: 604 NDLLTITLEECKSNAERMSMLVGKYE-SNATALRLALQYSEQCIEAYELLLALAESEQSL 662
L + +E + E MS L+ AT + +E E L + E +Q+
Sbjct: 968 R-LERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQAT 1026
Query: 663 -----------ILGQFRAAGVGS----SPGDQSGDEN--ITQMLKRAHDCRKTAENAAKA 705
++G+ G G+ G+Q +EN + L+RAH+ + EN A
Sbjct: 1027 SPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHE-QAVKENVKMA 1085
Query: 706 LLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQ 765
+ + + L SS TEF ++ + ++QQ
Sbjct: 1086 TEIS----------------RLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQ 1129
Query: 766 LKNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLE-NAVLMQELMAMKEEMAELKA 824
+ + L + D +V+ G + ++ V ++E A E +EL+
Sbjct: 1130 NRTKQVEGVTRRHVLSDLEDD----EVRDLGSTGTSSVQRQEVKIEESEASVEGFSELEN 1185
Query: 825 QLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPG 884
E ++ ELK + QEQ + L ++ + E++ L S K
Sbjct: 1186 S---EETRTESWELKNQISQLQEQLMM-----LCADCDRASEKKQDLLFDVSVLKKKLKM 1237
Query: 885 KECADAASPALSL----AELRTTCSENEL---AAEFTNAIRREKKLKARVQELVSALERL 937
E ASP L C + EL + A+ K+L A V L L+++
Sbjct: 1238 LERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKM 1297
Query: 938 TKSSE 942
+ +E
Sbjct: 1298 EEVTE 1302
Score = 58.9 bits (141), Expect = 2e-08
Identities = 199/1025 (19%), Positives = 390/1025 (38%), Gaps = 208/1025 (20%)
Query: 37 EERMRRLFQTCDGDGDGYISRNDLL----MVCRQLNMEESVAEIMNQLGADENGKISFQD 92
+E++ L CD + + DLL ++ ++L M E + E A K+ ++D
Sbjct: 1204 QEQLMMLCADCDRASE---KKQDLLFDVSVLKKKLKMLERIPE------ASPKYKLLYED 1254
Query: 93 FTRCRMQLVREIRKEEV--DLSAKSDNSCTK---KLRDRIASWPTSSDNSLGALSAARES 147
+R L E+R E D + +++ T +L+D + ++ L S +
Sbjct: 1255 VSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFL---SLEKSY 1311
Query: 148 WEYDSGARDLQSPDVQSQSALQKLLEYGGSSLHQQAALHKLLTQSPHIGNSVGGSYLELA 207
E +L ++ Q ++KL E S+ Q+ ++ G+ L+L
Sbjct: 1312 DEVKIENEELNVLVLRLQGKIEKLQE----SVVQRCDCCLWEASLENLEIEPDGNILQLN 1367
Query: 208 NTLHSAA--LASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHED------ 259
TL + S+ I E + Q E LLEK A ++ H++
Sbjct: 1368 QTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQN 1427
Query: 260 ---VQERTTLR-YEERITELHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQH-EV 314
++E TTL ++++ + + IAEL + +LQ T + ++ + L + H E
Sbjct: 1428 QVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEK 1487
Query: 315 NEDSRSMDQD-QTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGL--ENVVCGRKKSSC 371
E+ ++M D Q + S + + ++ + + NS L+ +T L E+ + K +
Sbjct: 1488 EEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTL 1547
Query: 372 SLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPN---------LAEERSRWE 422
+ S E+ + E T + K VE ++ + N L+++ S+ +
Sbjct: 1548 NGSQEEMWQKTE---TVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQ 1604
Query: 423 KELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGP 482
++L +E N+ LT MLC KE+E N+ EER++ + ++E
Sbjct: 1605 EKL---QELNQRLTEMLCQKEKEPG------NSALEEREQEKFNLKE------------- 1642
Query: 483 SSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEIS 542
EL ER K+ + SS L +E+S
Sbjct: 1643 ------------------EL---------------ERCKVQSSTLVSS------LEAELS 1663
Query: 543 SIGVSSSVAEHLAHSLQD----------CSNIQEIFQTLYSHGSAISESKIREFEVETER 592
+ + + + + H L+D C ++ + FQ S + +E ++E E +E
Sbjct: 1664 EVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSD-FQQKISSVLSYNEKLLKEKEALSEE 1722
Query: 593 LNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYELL 652
LNS ++ L +++ LL + K + +E + +L+ L S++ ++ E
Sbjct: 1723 LNSCVDKL-AKSSLLEHRIATMKQEQK-------SWEHQSASLKSQLVASQEKVQNLEDT 1774
Query: 653 LALAESEQSLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAKALLMKLDG 712
+ + S + R Q E + Q + H K +NA
Sbjct: 1775 VQNVNLQMSRMKSDLRVT--------QQEKEALKQEVMSLH---KQLQNA---------- 1813
Query: 713 SCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKE------DEQRLKDYIQQL 766
GG + P S H + D +E + +RL+ +Q
Sbjct: 1814 --GGKSWAPEIATHP-----SGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNT 1866
Query: 767 KNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELK--- 823
K + + + +LES + + P G + E L +E ++E +
Sbjct: 1867 KAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKV 1926
Query: 824 AQLYLLEKEKKALELK---LSTREAQEQAYLVHIEHLKSEV------------------- 861
+Q+ LE+E + + L+ L ++ + L+ ++HL+S
Sbjct: 1927 SQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQAC 1986
Query: 862 ----EEQKEQRMRSL---SSTSSGSKDKPGKECADAASPALSLAELRTTCSENELAAEFT 914
EQ Q R L + +++ ++ +P + +L T E + E
Sbjct: 1987 PMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVE-- 2044
Query: 915 NAIRREKKLKARVQELVSALERLTKSSEIRHQQSAEFVNDLKRANSNLVAAYEKAKKKHQ 974
++ K +K +QE V+ L K ++ ++ V DL N+ L+ A E +++ +
Sbjct: 2045 ---QKLKLVKRLLQEKVNQL----KEQLCKNTKADAMVKDLYVENAQLLKALEVTEQRQK 2097
Query: 975 NKLKK 979
KK
Sbjct: 2098 TAEKK 2102
Score = 52.4 bits (124), Expect = 2e-06
Identities = 186/915 (20%), Positives = 349/915 (38%), Gaps = 160/915 (17%)
Query: 142 SAARESWEYDSGARDLQSPDVQSQSALQKLLEY-------GGSSLHQQAALHKLLTQSPH 194
+A RE E + LQS + Q A L G + AL LL Q
Sbjct: 1000 TADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGAL-SLLQQGEQ 1058
Query: 195 IGNSVGGSYLELANTLHSAALASLK--GDIVELNKRLQQTERERDLLEKKLAKAQCEQS- 251
+ G L L A ++K +I L +RLQ+ LE L + C
Sbjct: 1059 LLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQK-------LEPGLVMSSCLDEP 1111
Query: 252 ------HLMREHEDVQERTTLRYEERITELHSVIAELNKKIDRLQGTTIREEDEYSELRS 305
+ + E ++ + E +T H V+++L R G+T + E++
Sbjct: 1112 ATEFFGNTAEQTEPFLQQNRTKQVEGVTRRH-VLSDLEDDEVRDLGSTGTSSVQRQEVKI 1170
Query: 306 ELSQ------SQHEVNEDSRSMDQD-QTSVSIPENQSTMVTADMDNCSDLNSELQRVLTG 358
E S+ S+ E +E++R+ + + +S + Q M+ AD D S+ +L
Sbjct: 1171 EESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDL------ 1224
Query: 359 LENVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPNLAEER 418
L +V +KK + +E++ AS L + V L +L
Sbjct: 1225 LFDVSVLKKKL----------KMLERIPEASPKYKLLYEDVSRENDCLQEEL----RMME 1270
Query: 419 SRWEKELAGLREENESLTAMLCSKEEELNRTKA---TMNAIREERDRLRRRVRELQTRLQ 475
+R+++ L E N+ LTA + ++EL + + T ++ + D ++ EL +
Sbjct: 1271 TRYDEAL----ENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVL 1326
Query: 476 SVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRP 535
+Q G++ + +S ++ I ++L++T E R
Sbjct: 1327 RLQ-------GKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRS 1379
Query: 536 VLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVETER--L 593
V H +++C + Y G+ K++ E+ +
Sbjct: 1380 V------------------HHVIEECKQ-----ENQYLEGNTQLLEKVKAHEIAWLHGTI 1416
Query: 594 NSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYELLL 653
+ E + QN ++ LEE N + ++ AT L L+ ++ EL
Sbjct: 1417 QTHQERPRVQNQVI---LEE---NTTLLGFQDKHFQHQATIAELELEKTK----LQELTR 1466
Query: 654 ALAESEQSLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKT-AENAAKALLMKLDG 712
L E ++++ Q G +E + M+ HD + T +E K L++ +
Sbjct: 1467 KLKE-RVTILVKQKDVLSHGEK------EEELKAMM---HDLQITCSEMQQKVELLRYES 1516
Query: 713 SCGGAFAVAGCSVQPWESLSSNSHTSTTSSTA-SSCDTEFTKEDEQRLKDYIQQLKNDRA 771
+Q S+ N T+ + S+ ++ + + +K + A
Sbjct: 1517 E----------KLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENA 1566
Query: 772 AVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQL--YLL 829
AV+ M+E I L +Q+LDLEN L Q+ +E++ EL +L L
Sbjct: 1567 AVQ-KMVENLKKQISELKIK------NQQLDLENTELSQKNSQNQEKLQELNQRLTEMLC 1619
Query: 830 EKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSSG-SKDKPGKECA 888
+KEK+ L RE ++ +LK E+E K Q +SS + S+ K
Sbjct: 1620 QKEKEPGNSALEEREQEK-------FNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIV 1672
Query: 889 DAASPAL-----SLAELRTTCSENELAAEFTNAIRREKKL----KARVQELVSALERLTK 939
+ L + +L ++ + ++ + +KL +A +EL S +++L K
Sbjct: 1673 QQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAK 1732
Query: 940 SSEIRH------QQSAEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMMAMVERHET 993
SS + H Q+ + + S LVA+ EK + L+ + + R ++
Sbjct: 1733 SSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQ-----NLEDTVQNVNLQMSRMKS 1787
Query: 994 QVRMLKQRIALLEEE 1008
+R+ +Q L++E
Sbjct: 1788 DLRVTQQEKEALKQE 1802
Score = 37.0 bits (84), Expect = 0.095
Identities = 22/75 (29%), Positives = 40/75 (53%), Gaps = 4/75 (5%)
Query: 37 EERMRRLFQTCDGDGDGYISRNDLLMVCRQLNMEESVAEIMNQLGADEN--GKISFQDFT 94
E R++ LF + D G G + + +L +C L++EE VA ++ Q +N G++ F F
Sbjct: 10 EARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEE-VAPVLQQTLLQDNLLGRVHFDQFK 68
Query: 95 RCRMQLV-REIRKEE 108
+ ++ R + EE
Sbjct: 69 EALILILSRTLSNEE 83
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 77.0 bits (188), Expect = 8e-14
Identities = 174/849 (20%), Positives = 338/849 (39%), Gaps = 121/849 (14%)
Query: 224 ELNKRLQQTERERDLLEKKLAKA----QCEQSHLMREHEDVQERTTLRYEERITELHSVI 279
EL+ QT++ + LE K+ + Q + +++EHE +RT +++I +L ++
Sbjct: 706 ELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLL 765
Query: 280 AELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVT 339
E +K + Q L +++ +S+ E+ + S +D Q+ S Q+
Sbjct: 766 KERDKHLKEHQA-------HVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYE 818
Query: 340 ADMDNCSD--LNSELQRV-LTGLENVVCGRKKSSCSLSVAEVDRH-------IEQLTTAS 389
+ L+ E +R+ LT V +KK C+ E+D H ++QL +
Sbjct: 819 EQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCT----ELDAHKIQVQDLMQQLEKQN 874
Query: 390 EHCDLAIKTVEEI------EGVLGRDLYPNLAEERSRWEKEL-AGLREENESLTAMLCSK 442
+ +K++ ++ +G ++ + E+ ++ G ++E E LT L +K
Sbjct: 875 SEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAK 934
Query: 443 EEE---LNRTKATMNAIREER-DRLRRRVRELQTRLQ--------SVQATGPSSPGRLTS 490
E+ LN T +E++ ++++++ +E+Q L+ ++ ++ L+
Sbjct: 935 EDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQ 994
Query: 491 TNRPINPSTGELSTSSSSNDIPIAKIAERV-KLSKTRSESSSSDRPVLGSEISSIGVSSS 549
+ N E++ ++S A I++ V +L + E S V E++ V S
Sbjct: 995 KEKQFNAKMLEMAQANS------AGISDAVSRLETNQKEQIESLTEVHRRELND--VISI 1046
Query: 550 VAEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVETERLNSRIEHLKSQNDLLTI 609
+ L ++ I EI A + KI F E E +N I LK +
Sbjct: 1047 WEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDT 1106
Query: 610 TLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYELLLALAESEQSLI----LG 665
TL E + ++ S V + T L+ L+ E ++ + L ++ L+ L
Sbjct: 1107 TLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLE--VDLNKSLKENTFLQEQLVELKMLA 1164
Query: 666 QFRAAGVGSSPGDQSGDENITQMLKRAHD-CRKTAEN-------AAKALLMKLDGSCGGA 717
+ V + Q LK +H+ K+ E+ ++ L ++LD C
Sbjct: 1165 EEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKT 1224
Query: 718 FAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTM 777
A+ ++SS S T+ S S C TK E L
Sbjct: 1225 EALLEAKTNELINISS-SKTNAILSRISHCQHRTTKVKEALL------------------ 1265
Query: 778 LELESIHIDPLSYDVKPRGDSQR-LDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKAL 836
+++ + L ++ + Q L++ +L + ++ +KA + L EK+AL
Sbjct: 1266 --IKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEAL 1323
Query: 837 ELKLSTREAQEQAYLVHIEHLKSEVEE-------QKEQRMRSLSSTSSGSKDKPGKECAD 889
+ + ++ I LK E+ E KE+ SS SK
Sbjct: 1324 QKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQL 1383
Query: 890 AASPALSLAELRTTCSENELAAEFTNAIRREKKLKARV----QELVSALERLTKSSEIRH 945
S +LS E + + E + + + L +V +E +SALE++
Sbjct: 1384 QNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQV-------D 1436
Query: 946 QQSAEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQM-MAMVERHE--TQVRMLKQRI 1002
S +F K+A S +HQN +K+L+ Q+ + E +E Q+ +LK+
Sbjct: 1437 DWSNKFSEWKKKAQSRFT--------QHQNTVKELQIQLELKSKEAYEKDEQINLLKEE- 1487
Query: 1003 ALLEEENSR 1011
L+++N R
Sbjct: 1488 --LDQQNKR 1494
Score = 75.1 bits (183), Expect = 3e-13
Identities = 164/877 (18%), Positives = 348/877 (39%), Gaps = 121/877 (13%)
Query: 181 QQAALHKLLTQSPHIGNSVGGSYLELANT----------LHSAALASLKGDI--VELNKR 228
Q+ KLL Q + + + LEL+ + A A + + +E N++
Sbjct: 967 QETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQK 1026
Query: 229 LQ---QTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITELHSVIA----- 280
Q TE R L ++ + + + E +++ E E+ + EL I
Sbjct: 1027 EQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCE 1086
Query: 281 --ELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMV 338
E+NK+I L+ ++++ +EL+ +L Q VN S+ QD+T + + +
Sbjct: 1087 KEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVN----SLAQDETKLKAHLEKLEV- 1141
Query: 339 TADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDLAIKT 398
DLN L+ EN + + E R + +LT+ + D ++
Sbjct: 1142 --------DLNKSLK------ENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQS 1187
Query: 399 VEEIEGVLGRDLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEEL--NRTKATMNAI 456
++ + L E++S K+L+ EE + C K E L +T +N
Sbjct: 1188 LKSSHEKSNKSL-----EDKSLEFKKLS---EELAIQLDICCKKTEALLEAKTNELINIS 1239
Query: 457 REERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKI 516
+ + + R+ Q R V+ T T + +L+ ++ +I +
Sbjct: 1240 SSKTNAILSRISHCQHRTTKVKEALLIK----TCTVSELEAQLRQLTEEQNTLNISFQQA 1295
Query: 517 AERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGS 576
+++ + + +S +D L +E ++ + A + C I ++ + L + +
Sbjct: 1296 THQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESC--ITQLKKELSENIN 1353
Query: 577 AIS--ESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATA 634
A++ + +++E +VE L+ ++ L Q + + E A
Sbjct: 1354 AVTLMKEELKEKKVEISSLSKQLTDLNVQ-----------------LQNSISLSEKEAAI 1396
Query: 635 LRLALQYSEQCIEAYELLLALAESEQSLILGQFRAAGVGSSPGDQSGD--ENITQMLKRA 692
L QY E+ E + + L+ +L + A +Q D ++ K+A
Sbjct: 1397 SSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISAL-------EQVDDWSNKFSEWKKKA 1449
Query: 693 HDCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFT 752
+N K L ++L+ A+ + E ++ + C
Sbjct: 1450 QSRFTQHQNTVKELQIQLELKSKEAY-------EKDEQINLLKEELDQQNKRFDCLKGEM 1502
Query: 753 KEDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDVKPRGD-----SQRLDLENAV 807
++D+ +++ L+ + + ++ELE HI + +++ + +Q+ D+E+
Sbjct: 1503 EDDKSKMEKKESNLETELKSQTARIMELED-HITQKTIEIESLNEVLKNYNQQKDIEHKE 1561
Query: 808 LMQELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQ 867
L+Q+L +E E ++ E++ LE ++ + +A+ + +EH+ V+ KE+
Sbjct: 1562 LVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKS-KEE 1620
Query: 868 RMRSLSSTSSGSKDKPGKECADAASPALSLAELRTTCSENELAAEFTNAIRREKK----- 922
+++L +D+ E A + AE + + +L ++ + KK
Sbjct: 1621 ELKAL-------EDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESH 1673
Query: 923 ---LKARVQEL---VSALERLTKSSEIRHQQSAEFVNDLKRANSNLVAAYEKAKKKHQNK 976
L ++QE V LE KS E QS + + R+ N+ A E+ + Q
Sbjct: 1674 LSELNTKLQEREREVHILEEKLKSVE--SSQSETLI--VPRSAKNVAAYTEQEEADSQGC 1729
Query: 977 LKKLESQMMAMVERHETQVRMLKQRIALLEEENSRPH 1013
++K + +++++R+ T+ L QR+ +EE H
Sbjct: 1730 VQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSH 1766
Score = 66.6 bits (161), Expect = 1e-10
Identities = 185/947 (19%), Positives = 346/947 (36%), Gaps = 214/947 (22%)
Query: 262 ERTTLRYEERITELHSVIAELNKKIDRLQGTTIREEDE----YSELRSELSQSQ----HE 313
ER+ Y + +EL + L ++ +LQG + +D+ +ELR EL Q H
Sbjct: 147 ERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREELQMDQQAKKHL 206
Query: 314 VNEDSRSMDQD-------QTSVSI---------------------------------PEN 333
E S+++ QT VS+ PE+
Sbjct: 207 QEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPES 266
Query: 334 QSTMVTADMDNCSDLNSELQRVLTGLENVVCGRK------KSSCSLSVAEVDRHIEQLTT 387
V D + L + QRV EN++ K K C+L +E + EQL
Sbjct: 267 DGEPVVEDGTSVKTLETLQQRV-KRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDE 325
Query: 388 ASEHCD------LAIKT---------------VEEIEGVLGRDLYPNLAEERSRWEKELA 426
+ + +A KT +E+ +G++ + + E E+E+A
Sbjct: 326 RLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIA 385
Query: 427 GLREENESLTA----MLCSKE-------EELNRTKATMNAIREERDRLRRRVRELQTRLQ 475
LR + +T + KE EEL + +T E R +L+ E+ +++
Sbjct: 386 QLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLK---AEMDEQIK 442
Query: 476 SVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSS--SD 533
+++ T L + ++ SS I + +L++ E +
Sbjct: 443 TIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQT 502
Query: 534 RPVLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAI---SESKIREFEVET 590
R E + + S +E+L S + + L AI SE+K+R+ + E
Sbjct: 503 REREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEA 562
Query: 591 ERLNSRIEHL-----------KSQNDLLTITLE-ECKSNAERMSMLVGKYESNATALR-- 636
E +RI L K+Q+ L + LE E + + ++++V K+++ +L+
Sbjct: 563 ETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQ 622
Query: 637 -----------LALQYS-------EQCIEAYELLLALAESEQSLILGQFRAAGVGSSPGD 678
L QY E+C + E LL E + + +
Sbjct: 623 QDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVK 682
Query: 679 QSGDENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTS 738
Q+ E+++ L R E L + D ++ N H
Sbjct: 683 QTELESLSSELSEVLKARHKLEEELSVLKDQTD--------KMKQELEAKMDEQKNHHQQ 734
Query: 739 TTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDVK-PRGD 797
S + + E+ LKD I QL+ + L+ H++ L D+K G+
Sbjct: 735 QVDSIIKEHEVSI-QRTEKALKDQINQLEL-LLKERDKHLKEHQAHVENLEADIKRSEGE 792
Query: 798 SQRLDLENAVLM-------QELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQ-- 848
Q+ + V ++ A +E++A+L+ +L LE E+ L +++ EAQ++
Sbjct: 793 LQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDV 852
Query: 849 -----AYLVHIEHLKSEVEEQK---EQRMRSL-----SSTSSGSKDKP------------ 883
A+ + ++ L ++E+Q EQ+++SL S G+K++
Sbjct: 853 CTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENM 912
Query: 884 -------GKECADAASPALSLAELRTTCSENELAAEFTNAIRREKKLKARVQELVSALER 936
K+ + + LS E E +F N ++ +K+K + +E+ L++
Sbjct: 913 ILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKK 972
Query: 937 L---------------------------TKSSEIRHQQSAEFVNDLKRANSNLVAAYEKA 969
K E+ SA + + R +N E
Sbjct: 973 KLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESL 1032
Query: 970 KKKHQNKL--------KKLESQMMAMVERHETQVRMLKQRIALLEEE 1008
+ H+ +L KKL Q + E HE Q++ +Q +A L+++
Sbjct: 1033 TEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQK 1079
Score = 64.7 bits (156), Expect = 4e-10
Identities = 169/909 (18%), Positives = 344/909 (37%), Gaps = 114/909 (12%)
Query: 156 DLQSPDVQSQSALQKLLEYGGSSLHQQAALHKLLTQSPHIGNSVGGSYLELANTLHSAAL 215
+L + +Q Q +Q+L E S + Q+ K LTQ V S LE N
Sbjct: 855 ELDAHKIQVQDLMQQL-EKQNSEMEQKV---KSLTQ-------VYESKLEDGNKEQEQTK 903
Query: 216 ASLKGDIVELNKRLQQTE---RERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERI 272
L + + N LQ E +E ++L +KL+ A+ + H++ E + + + + E++
Sbjct: 904 QIL---VEKENMILQMREGQKKEIEILTQKLS-AKEDSIHILNEEYETKFKNQEKKMEKV 959
Query: 273 TELHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPE 332
+ + E KK Q +++E E + L ELSQ + + N M Q S I +
Sbjct: 960 KQKAKEMQETLKKKLLDQEAKLKKELENTAL--ELSQKEKQFNAKMLEMAQ-ANSAGISD 1016
Query: 333 NQSTMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTASEHC 392
S + T + L +R L + S+ ++++ E+L E
Sbjct: 1017 AVSRLETNQKEQIESLTEVHRRELNDV-----------ISIWEKKLNQQAEELQEIHE-- 1063
Query: 393 DLAIKTVEEIEGVLGRDLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKAT 452
+ ++ E+ L + + E+ KE+ L+EE L +E+L + A
Sbjct: 1064 -IQLQEKEQEVAELKQKILL-FGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAH 1121
Query: 453 MNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIP 512
+N++ ++ +L+ + +L+ L + N + EL + +
Sbjct: 1122 VNSLAQDETKLKAHLEKLEVDL-----------NKSLKENTFLQEQLVELKMLAEEDKRK 1170
Query: 513 IAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVS-SSVAEHLAHSLQDCSNIQEIFQTL 571
++++ ++K + +S S + + ++E LA L C E
Sbjct: 1171 VSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTE----- 1225
Query: 572 YSHGSAISESKIREF----EVETERLNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGK 627
A+ E+K E +T + SRI H + + + L + + +
Sbjct: 1226 -----ALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQ 1280
Query: 628 YESNATALRLALQYSEQCIEAYELLLALAESEQSLILGQFRAAGVGSSPGDQSGDEN--- 684
L ++ Q + +E E + +++ ++ + A Q+ E
Sbjct: 1281 LTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESC 1340
Query: 685 ITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTA 744
ITQ+ K + + L K + + +VQ S+S + + SS
Sbjct: 1341 ITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLR 1400
Query: 745 SSCDTEFTKEDEQRLKDYIQQLK---NDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRL 801
D E++ L D +Q L + + K++ LE + S + K + S+
Sbjct: 1401 KQYD-----EEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFS-EWKKKAQSRFT 1454
Query: 802 DLENAVLM----------------QELMAMKEEM-----------AELKAQLYLLEKEKK 834
+N V +++ +KEE+ E++ +EK++
Sbjct: 1455 QHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKES 1514
Query: 835 ALELKLSTREAQEQAYLVHIEHLKSEVEEQKE-----QRMRSLSSTSSGSKDKPGKECAD 889
LE +L ++ A+ HI E+E E + + + K + +E +
Sbjct: 1515 NLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGE 1574
Query: 890 AASPALSLAELRTTCSENELAAEFTNAIRREKKLKARVQELVSALERLTKSSEIRHQQSA 949
+ AE + EN++ + ++K+L+ + S E L + +SA
Sbjct: 1575 EKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESA 1634
Query: 950 EFVNDLKRANSNLVAAYEK-----AKKKHQNKLKKLESQMMAM---VERHETQVRMLKQR 1001
+ +LKR +AA +K ++K + K ES + + ++ E +V +L+++
Sbjct: 1635 AKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEK 1694
Query: 1002 IALLEEENS 1010
+ +E S
Sbjct: 1695 LKSVESSQS 1703
Score = 56.2 bits (134), Expect = 2e-07
Identities = 165/948 (17%), Positives = 348/948 (36%), Gaps = 154/948 (16%)
Query: 108 EVDLSAKSDNSCTKKLRDRIASWPTSSDNSLGALSAARESWEYDSGARDLQSPDVQSQSA 167
E+ + A+ D +L ++ + +D +L ++ E + L+ + + A
Sbjct: 1159 ELKMLAEEDKRKVSELTSKLKT----TDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELA 1214
Query: 168 LQKLLEYGGSSLHQQAALHKLLTQSPHIGNSVGG--SYLELANTLHSAALASLKGDIVEL 225
+Q + + +A ++L+ S N++ S+ + T AL + EL
Sbjct: 1215 IQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSEL 1274
Query: 226 NKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITELHSVIAELNKK 285
+L+Q E++ L +A +H + E E+ + E +TE + L K+
Sbjct: 1275 EAQLRQLTEEQNTLNISFQQA----THQLEEKENQIKSMKADIESLVTEKEA----LQKE 1326
Query: 286 IDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTADMDNC 345
Q +E ++L+ ELS++ + V + + + +S Q T
Sbjct: 1327 GGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLT--------- 1377
Query: 346 SDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGV 405
DLN +LQ ++ K+++ S + D +L + + T+ + E +
Sbjct: 1378 -DLNVQLQN------SISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSK-EKI 1429
Query: 406 LGRDLYPNLAEERSRWEKELAGLREENES----LTAMLCSKEEELNRTKATMNAIREERD 461
+ + + + S W+K+ ++++ L L K +E +N ++EE D
Sbjct: 1430 SALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELD 1489
Query: 462 RLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVK 521
+ +R L+ G + + L T S I ++ + +
Sbjct: 1490 QQNKRFDCLK--------------GEMEDDKSKMEKKESNLETELKSQTARIMELEDHIT 1535
Query: 522 LSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISES 581
ES L + + + EH +Q + QE+ + ++
Sbjct: 1536 QKTIEIES-------LNEVLKNYNQQKDI-EH-KELVQKLQHFQELGEE--------KDN 1578
Query: 582 KIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQY 641
+++E E + L +++ +K++ LE K E +++ V E AL L+
Sbjct: 1579 RVKEAEEKILTLENQVYSMKAE-------LETKKKELEHVNLSVKSKEEELKALEDRLE- 1630
Query: 642 SEQCIEAYELLLALAESEQSLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAEN 701
SE + EL AE + + I Q ++QM ++ +K E+
Sbjct: 1631 SESAAKLAELKRK-AEQKIAAIKKQL-----------------LSQMEEKEEQYKKGTES 1672
Query: 702 AAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKD 761
L KL Q E S +S +T + +
Sbjct: 1673 HLSELNTKL---------------QEREREVHILEEKLKSVESSQSETLIVPRSAKNVAA 1717
Query: 762 YIQQLKND-RAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAMKEEMA 820
Y +Q + D + V+ T E S+ QR E L+Q + KEE
Sbjct: 1718 YTEQEEADSQGCVQKTYEEKISV--------------LQRNLTEKEKLLQRVGQEKEETV 1763
Query: 821 ELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKE-------QRMRSLS 873
++ +E+ +KL EA++ I HL+ E+EE+ + Q +
Sbjct: 1764 SSHFEMRCQYQERL---IKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEG 1820
Query: 874 STSSGSKDKPGKECADAASPALSLAELRTTCSENELAAEFTNAIRREKKLKARVQELVSA 933
++ + + D L EL E ++ + +R+++ + ++EL S
Sbjct: 1821 GKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSK 1880
Query: 934 LERL-------------------TKSSEIRHQQSAEFVNDLKRANSNL---VAAYEKAKK 971
E+L T+ H + +++++ +++L +A E+ K+
Sbjct: 1881 YEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQ 1940
Query: 972 KHQNKLKKLESQMMAMVERHETQVRMLKQRIALLEEENSRPHTNETSL 1019
K ++ +L+ + + + H+ ++ +LK+ EE + + L
Sbjct: 1941 KLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLEL 1988
Score = 53.1 bits (126), Expect = 1e-06
Identities = 149/826 (18%), Positives = 322/826 (38%), Gaps = 99/826 (11%)
Query: 215 LASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMRE-HEDVQERTTLRYE--ER 271
+ S+K DI L + ++E ++ ++ + + L +E E++ T ++ E E+
Sbjct: 1306 IKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEK 1365
Query: 272 ITELHSVIAELNKKIDRLQGTTIREEDE--YSELRSELSQSQHEVNEDSRSMDQDQTSVS 329
E+ S+ +L +LQ + E E S LR + + + E+ + + + ++S
Sbjct: 1366 KVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLS 1425
Query: 330 IPENQSTMVTADMDN-CSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTA 388
+ + D N S+ + Q T +N V + L E EQ+
Sbjct: 1426 KEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTV-KELQIQLELKSKEAYEKDEQINLL 1484
Query: 389 SEHCDLAIKTVEEIEGVLGRDLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEELNR 448
E D K + ++G + +++S+ EK+ + L E +S TA + E+ + +
Sbjct: 1485 KEELDQQNKRFDCLKG--------EMEDDKSKMEKKESNLETELKSQTARIMELEDHITQ 1536
Query: 449 TKATMNAIREERDRLRRRV----RELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELST 504
+ ++ E ++ +EL +LQ Q G R+ I ++ +
Sbjct: 1537 KTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYS 1596
Query: 505 SSSSNDIPIAKIAERVKLS-KTRSESSSSDRPVLGSEISS--IGVSSSVAEHLAHSLQDC 561
+ + K E V LS K++ E + L SE ++ + + +A +
Sbjct: 1597 MKAELETK-KKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQL 1655
Query: 562 SNIQEIFQTLYSHG--SAISE--SKIREFEVETERLNSRIEHLKSQNDLLTITLEECKS- 616
+ E + Y G S +SE +K++E E E L +++ ++S I K+
Sbjct: 1656 LSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNV 1715
Query: 617 -------NAERMSMLVGKYESNATALRLALQYSEQCIEAYELLLALAESEQSLILGQF-- 667
A+ + YE + L+ L E+ LL + + ++ + F
Sbjct: 1716 AAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEK------LLQRVGQEKEETVSSHFEM 1769
Query: 668 ------RAAGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAVA 721
R + + Q D+++ L+ + + + A ++ +G
Sbjct: 1770 RCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKN------ 1823
Query: 722 GCSVQPWESLSS--NSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLE 779
++Q ++L + + T +C EQ++K+ L + ++ M E
Sbjct: 1824 --NIQAKQNLENVFDDVQKTLQEKELTCQIL-----EQKIKELDSCLVRQKEVHRVEMEE 1876
Query: 780 LESIH-----IDPLSYDVKP----RGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLE 830
L S + + + KP +++ + V + L M+ + +L+ +L E
Sbjct: 1877 LTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAE 1936
Query: 831 KEKKAL---------ELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSSGSKD 881
+EK+ L +L++ +E Q++ +E LK E ++++E++++ +
Sbjct: 1937 REKQKLGKEIVRLQKDLRMLRKEHQQE-----LEILKKEYDQEREEKIKQEQEDLELKHN 1991
Query: 882 KPGKECADAASPALSLAE--LRTTCSEN-----ELAAEFTNAIRRE-----KKLKARVQE 929
K+ + L+ E L T E E+ AE + + E KK+ + +
Sbjct: 1992 STLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDD 2051
Query: 930 LVSALERLTKSSEIRHQQSAEFVNDLKRANSNLVAAYEKAKKKHQN 975
L +R + + R ++ V DL+ L Y++ ++ +N
Sbjct: 2052 LKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEEN 2097
Score = 41.6 bits (96), Expect = 0.004
Identities = 91/467 (19%), Positives = 175/467 (37%), Gaps = 83/467 (17%)
Query: 66 QLNMEESVAEIMNQLGADENGKISFQDFTRCRMQLVREIRKEEVDLSAKSDNSCTKKLRD 125
Q N+ E +++ ++G ++ +S RC+ Q R I+ E + D S L++
Sbjct: 1742 QRNLTEK-EKLLQRVGQEKEETVSSHFEMRCQYQ-ERLIKLEHAEAKQHEDQSMIGHLQE 1799
Query: 126 R----------IASWPTSSDNSLGALSAARESWE-YDSGARDLQSPDVQSQSALQKLLEY 174
I + + + A + +D + LQ ++ Q QK+ E
Sbjct: 1800 ELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKEL 1859
Query: 175 GGSSLHQQAALH------------KLLTQSPHIGNSVGGSYLE-------LANTLHSAAL 215
S L +Q +H KL G + LE ++ + L
Sbjct: 1860 D-SCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLL 1918
Query: 216 ASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITEL 275
++++ +L +L ERE+ L K++ + Q + L +EH+ E
Sbjct: 1919 SNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELE------------- 1965
Query: 276 HSVIAELNKKIDRLQGTTIREEDEYSELR--SELSQSQHEVNEDSRSMDQDQTSVSIPEN 333
L K+ D+ + I++E E EL+ S L Q E N +Q + ++I E
Sbjct: 1966 -----ILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQ-ELEMTIKET 2019
Query: 334 QSTMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCD 393
+ + + E ++L +AE D +++ TA + +
Sbjct: 2020 INKAQEVEAELLESHQEETNQLLK----------------KIAEKDDDLKR--TAKRYEE 2061
Query: 394 LAIKTVEEIEGVLGRDLYPNLAEERSRWEKELAGLREENE--------SLTAMLCSKEEE 445
+ EE+ + RDL L E + +++++L +EEN L L K
Sbjct: 2062 ILDAREEEMTAKV-RDLQTQLEELQKKYQQKLE--QEENPGNDNVTIMELQTQLAQKTTL 2118
Query: 446 LNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTN 492
++ +K RE+ L R+++ + + + P G L T+
Sbjct: 2119 ISDSKLKEQEFREQIHNLEDRLKKYEKNVYATTVGTPYKGGNLYHTD 2165
Score = 38.5 bits (88), Expect = 0.033
Identities = 140/677 (20%), Positives = 259/677 (38%), Gaps = 125/677 (18%)
Query: 408 RDLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDR--LRR 465
+ L ++EE+ + ++ LA + + S T R ++ ++ E+ D R
Sbjct: 3 KKLKQKISEEQQQLQQALAPAQASSNSSTP---------TRMRSRTSSFTEQLDEGTPNR 53
Query: 466 RVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKT 525
+ Q+ Q +Q PS S PI S L SSS + E +
Sbjct: 54 ESGDTQSFAQKLQLRVPSVESLFRS---PIKES---LFRSSSKESLVRTSSRESLNRLDL 107
Query: 526 RSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIRE 585
S ++S D P S AE L + D N +++ Q L ++S + +
Sbjct: 108 DSSTASFDPP---------SDMDSEAEDLVGN-SDSLNKEQLIQRLRRMERSLSSYRGKY 157
Query: 586 FEVETERLNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQC 645
E+ T + E K Q I + + R++ L + + + A + + +
Sbjct: 158 SELVTAYQMLQREKKKLQG----ILSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDAS 213
Query: 646 IEAYELLLALAESEQSLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAKA 705
+E + +++ +++ SL+ + R +G N+ +LK AE K
Sbjct: 214 LEEKDQYISVLQTQVSLLKQRLR-----------NGPMNV-DVLKPLPQLEPQAEVFTKE 261
Query: 706 LLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTS---------TTSSTASSCDTEFTKEDE 756
+ DG G SV+ E+L T S C T T E E
Sbjct: 262 ENPESDGE---PVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQC-TLLTSEKE 317
Query: 757 ---QRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLMQELM 813
++L + +Q+L+ + +L + D + + D + E M E +
Sbjct: 318 ALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETL 377
Query: 814 AMKEE-MAELKAQLYLL-----------EKEKKA----LELKLSTREAQEQAYLVHIEHL 857
MKEE +A+L++++ + EK ++A LE LST + E+A L
Sbjct: 378 EMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEAR----RKL 433
Query: 858 KSEVEEQ--------KEQRM---RSLSSTSSGSKDKPGKECADAASPALSLAELRTTCSE 906
K+E++EQ +E+R+ + LS D K + + L E E
Sbjct: 434 KAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKE 493
Query: 907 NELAAEFTNAIRR-EKKLKARVQELVS---------------ALERLTKSSEIRHQQSAE 950
EL + R ++++K +++ S ALE L + +S
Sbjct: 494 QELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESEN 553
Query: 951 FVNDLKRANSN-------LVAAYEKAKKKHQNKLKKL-----------ESQMMAMVERHE 992
+ DL++ L ++ EK+ ++++N+ K L ++ MVE+H+
Sbjct: 554 KLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHK 613
Query: 993 TQVRMLK-QRIALLEEE 1008
T++ LK Q+ AL E+
Sbjct: 614 TELESLKHQQDALWTEK 630
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 77.0 bits (188), Expect = 8e-14
Identities = 182/966 (18%), Positives = 359/966 (37%), Gaps = 167/966 (17%)
Query: 101 VREIRKEEVDLSAK---SDNSCTKKLRDRIASWPTSSDNSLGALSAARESWEYDSGARDL 157
++EI E+V+L K + + TKK + + L S S E + A L
Sbjct: 1311 LKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESL 1370
Query: 158 QSPDVQSQ----------------SALQKLLE--------YGGSSLHQQAALHKLLTQSP 193
Q SQ LQKL+ G ++AAL K+ T+
Sbjct: 1371 QQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEII 1430
Query: 194 HIGNSVGGSY--LELANTLHSAALASLKGDIVELNKR---LQQTERERDLLEKKLAKAQC 248
+ + + LE+ H + L+ ++ E+ ++ + + R + +++KL A
Sbjct: 1431 EQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALI 1490
Query: 249 EQSHLMREHEDVQERTTL------RYEERITELHSVIAELNKKIDRLQGTTIREEDEYSE 302
+ ++E++ +QE +L R + + ++ S ++ NK+ D + G ++E +
Sbjct: 1491 SRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDK 1550
Query: 303 LRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLENV 362
L +E+ +S + ENQS L+S + + LE +
Sbjct: 1551 LITEMDRS-------------------LLENQS------------LSSSCESLKLALEGL 1579
Query: 363 VCGRKKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPNLAEERSRWE 422
++K + + + E +H +L +E E +L Y N++ E R +
Sbjct: 1580 TEDKEKLVKEIESLKSSKIAESTEWQEKHKELQ----KEYEILL--QSYENVSNEAERIQ 1633
Query: 423 KELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGP 482
+ +R+E + L L S E T+ + +E + ++ ++R+ Q
Sbjct: 1634 HVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELE 1693
Query: 483 SSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEIS 542
RL + P + E + S++ + + ERVK+ E+ S L SE
Sbjct: 1694 EENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKM---EYETLSKKFQSLMSEKD 1750
Query: 543 SIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVETERLNSRIEHLKS 602
S+ S + L H ++ + Q + H +++ E T+ + E S
Sbjct: 1751 SL---SEEVQDLKHQIEGNVSKQANLEATEKH-----DNQTNVTEEGTQSIPGETEEQDS 1802
Query: 603 QNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYELLLALAESEQSL 662
+ T E +A+ + V K S+ + Y +Q + E + L E +Q
Sbjct: 1803 LSMSTRPTCSESVPSAKSANPAVSKDFSSHDEIN---NYLQQIDQLKERIAGLEEEKQ-- 1857
Query: 663 ILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAVAG 722
+ + +T EN LL ++ + G +
Sbjct: 1858 ----------------------------KNKEFSQTLENEKNTLLSQI-STKDGELKMLQ 1888
Query: 723 CSVQPWESLSSNSHTSTTSSTASSCDTEFTKED-EQRLKDYIQQLKNDRAAVKLTMLELE 781
V L+ + T E K+D E+RL + + +L
Sbjct: 1889 EEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGS------------ 1936
Query: 782 SIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKALELKLS 841
I DV D+Q ++N +L E+ +K+ ++EL+ + L KEK +E ++
Sbjct: 1937 ---IGNYCQDVT---DAQ---IKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIR 1987
Query: 842 TR-------EAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKECADAASPA 894
+E H + L+ E+ ++K+Q ++ L ++K A
Sbjct: 1988 KEYLEKIQGAQKEPGNKSHAKELQ-ELLKEKQQEVKQLQKDCIRYQEK-----ISALERT 2041
Query: 895 LSLAELRTTCSENELAAEFTN---AIRREKKLKARVQELVSALERLTKSSEIRHQQSAEF 951
+ E T S+ +L N A+ KK +A + L+ ++A
Sbjct: 2042 VKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDD-------TQSEAARV 2094
Query: 952 VNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMMAMVERHETQVRMLKQRIALLEEENSR 1011
+ D + L + E K + + K + LE ++ E+H + + +++++ L E +
Sbjct: 2095 LADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRRE--K 2152
Query: 1012 PHTNET 1017
H ET
Sbjct: 2153 VHLEET 2158
Score = 63.9 bits (154), Expect = 7e-10
Identities = 177/896 (19%), Positives = 342/896 (38%), Gaps = 152/896 (16%)
Query: 215 LASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITE 274
LA+LK E K + +E ER +E+ + + + + ++++ E+ E
Sbjct: 1016 LANLKD---ESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVE 1072
Query: 275 LHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQ 334
L + +L +K+ E+++ L +++Q+ + + + +D Q +S ENQ
Sbjct: 1073 LQHIRKDLEEKL--------AAEEQFQALVKQMNQT---LQDKTNQIDLLQAEIS--ENQ 1119
Query: 335 ST---MVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTASEH 391
+ ++T++ D SD +S V E VV C+ S +E+ A E
Sbjct: 1120 AIIQKLITSNTD-ASDGDS----VALVKETVVIS---PPCTGSSEHWKPELEEKILALE- 1170
Query: 392 CDLAIKTVEEIEGVLGRDLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKA 451
K E+++ L L A + EKE LREE L ++++ NR +
Sbjct: 1171 -----KEKEQLQKKLQEALTSRKAILKKAQEKE-RHLREE-------LKQQKDDYNRLQE 1217
Query: 452 TMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDI 511
+ +E + + ++R+LQ +++ S G+L ST++ E +S+ +
Sbjct: 1218 QFDEQSKENENIGDQLRQLQIQVRE------SIDGKLPSTDQQ------ESCSSTPGLEE 1265
Query: 512 PIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAH--------------- 556
P+ K E+ + D P + S++ +SVA+ A
Sbjct: 1266 PLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKV 1325
Query: 557 ---SLQDCSNIQEIFQT---LYSHGSAISESKI--REFEVETERLNSRIEHLKSQNDLLT 608
+ + +E+FQ + G I K E EV E L ++E + Q L
Sbjct: 1326 SSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLE 1385
Query: 609 ITLEECKSNAERMSMLVGKYESNATALRLALQYSE--------QCIEAYELLLAL----- 655
L E + + + L+ K E + + L L E + IE +L+ AL
Sbjct: 1386 -HLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLE 1444
Query: 656 ---AESEQSLILGQFRAAGVGSSP---GDQS-GDENITQMLKRAHDCRKTAENAAKALLM 708
E ++ + Q + P G++S + I + L+ A RK A K+L
Sbjct: 1445 MQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQE 1504
Query: 709 KLDGSCGGAFAVAGCSVQPWESLSSNSHTSTT-----SSTASSCDTEFTKEDEQRLKDYI 763
+L + G + +S+ + T + D T+ D L++
Sbjct: 1505 ELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLEN-- 1562
Query: 764 QQLKNDRAAVKLTM-----------LELESIHIDPLSYDVKPRGDSQRLDLENAVLMQEL 812
Q L + ++KL + E+ES+ ++ + + + L E +L+Q
Sbjct: 1563 QSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSY 1622
Query: 813 MAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSL 872
+ E ++ + + +EK+ L KL + EA ++ ++ + E+EE KE+ +
Sbjct: 1623 ENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFA 1682
Query: 873 SSTSSGSKD----------------KPGKECADA--ASPALSLAELRTTCSENE-LAAEF 913
S + KEC + +S A EL E E L+ +F
Sbjct: 1683 KSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKF 1742
Query: 914 TNAIRREKKLKARVQEL-------------VSALERLTKSSEIRHQQSAEFVNDLKRANS 960
+ + + L VQ+L + A E+ + + + + + + +S
Sbjct: 1743 QSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDS 1802
Query: 961 NLVAAYEKAKK-----KHQNKLKKLESQMMAMVERHETQVRMLKQRIALLEEENSR 1011
++ + K N + + + Q+ LK+RIA LEEE +
Sbjct: 1803 LSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQK 1858
Score = 62.8 bits (151), Expect = 2e-09
Identities = 192/977 (19%), Positives = 387/977 (39%), Gaps = 167/977 (17%)
Query: 67 LNMEESVAEIMNQLGA--DENGKISFQDFTRCRMQLVREIRKEEVDLSAKSDNSCTKKLR 124
L+++++ E+ + A D+N K+ QD +Q + I++ E L KS R
Sbjct: 382 LSLQKTGQELQSACDALKDQNSKL-LQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNR 440
Query: 125 DRIASWPTSSDNSLGALSAARESWEYDSGARDLQSPDVQS-QSALQKLLEYGGSSLHQQA 183
+ T+S S + Y+ G + + ++ S Q + +L G+ L
Sbjct: 441 LPLQQHETASQTSFPDV--------YNEGTQAVTEENIASLQKRVVELENEKGALLLSSI 492
Query: 184 ALHKLLTQSPHIGNSVGGSYLELANTLHSAALASLKGDIVEL-NKRLQQTERE-RDLLEK 241
L +L ++ + + + + LE N A + IV++ NKR E +D+LE
Sbjct: 493 ELEELKAENEKLSSQI--TLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLEN 550
Query: 242 KLAKAQCEQSHLMREHEDVQERTTLRYEERITELHSVIAELNKKIDRLQGTTIREEDEYS 301
++ E S L+ E ++ QE IA L + LQG E D
Sbjct: 551 TFSQKHKELSVLLLEMKEAQEE---------------IAFLKLQ---LQGKRAEEADHEV 592
Query: 302 ELRSELSQSQHE----VNEDSRSMDQDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLT 357
+ E+ Q + E + D Q +P +S++ + + S +
Sbjct: 593 LDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQS------ 646
Query: 358 GLENVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTV--------EEIEGVLGR- 408
R SL+ A V+ L + + D ++ V +E+E + +
Sbjct: 647 --------RTSEEISLNDAGVE-----LKSTKQDGDKSLSAVPDIGQCHQDELERLKSQI 693
Query: 409 -DLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRV 467
+L N + + +EK L +E +L ++ ++ + + A+ EERD+L +V
Sbjct: 694 LELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQV 753
Query: 468 RELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRS 527
+EL EL ++ +A+ AER + +
Sbjct: 754 KELS--------------------------MVTELRAQVKQLEMNLAE-AERQR--RLDY 784
Query: 528 ESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAI---SESKIR 584
ES ++ +L +I S+ + + + LQ N + Q +S S + +S+++
Sbjct: 785 ESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQ---NELDDVQLQFSEQSTLIRSLQSQLQ 841
Query: 585 EFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQ 644
E E R+ H+ S+ + L+ L + + +M L+ + + + L+ ++ +Q
Sbjct: 842 NKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQ 901
Query: 645 CIEAYELLLALAESEQSLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAK 704
+ E+ ++ E L +F + GV + LK + AE A K
Sbjct: 902 --QVTEISFSMTEKMVQLNEEKF-SLGVE------------IKTLKEQLNLLSRAEEAKK 946
Query: 705 ALLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEF---TKEDEQRLKD 761
+ + + G Q ++ +S S EF KE+EQR +
Sbjct: 947 EQVEEDNEVSSGL-------KQNYDEMSPAGQIS-----KEELQHEFDLLKKENEQRKRK 994
Query: 762 YIQQLKNDRAAV-KLTMLELESIHIDPLSYDVKPRGDSQR----LDLENAVLMQELMAMK 816
L N + + +++ LE E ++ S P +++R D EN ++ + K
Sbjct: 995 LQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSK 1054
Query: 817 EEMAELKAQLYLLEKE------KKALELKLSTREAQEQAYLV-----------HIEHLKS 859
+ E+ + + EKE +K LE KL+ E Q QA + I+ L++
Sbjct: 1055 CQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEE-QFQALVKQMNQTLQDKTNQIDLLQA 1113
Query: 860 EVEEQK---EQRMRSLSSTSSGSKDKPGKECADAASPALSLAE-LRTTCSENELAAEFTN 915
E+ E + ++ + S + S G KE + P +E + E LA E
Sbjct: 1114 EISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALE--- 1170
Query: 916 AIRREKKLKARVQELVSALERLTKSSEIRHQQSAEFVNDLKRANSNLVAAYEKAKKKHQN 975
+ +++L+ ++QE +++ + + K ++ + + E + K + L +++ K+++N
Sbjct: 1171 --KEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENEN 1228
Query: 976 ---KLKKLESQMMAMVE 989
+L++L+ Q+ ++
Sbjct: 1229 IGDQLRQLQIQVRESID 1245
Score = 58.9 bits (141), Expect = 2e-08
Identities = 138/729 (18%), Positives = 293/729 (40%), Gaps = 115/729 (15%)
Query: 216 ASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITEL 275
A L ++++ + L Q +D +K+L + Q +Q+ + E + EE++ E
Sbjct: 2527 AKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKEL-------ENKYAKLEEKLKES 2579
Query: 276 HSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMD--QDQTSVSIPEN 333
+L + + LQ +E +L E+ + +++ +R + Q++ ++ +
Sbjct: 2580 EEANEDLRRSFNALQ-------EEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHA 2632
Query: 334 QSTMVTADMDNCSDLNSELQRVLTGLEN-VVCGRKKSSCSLSVAEVDRHIEQLTTASEHC 392
Q + ++ S L S Q+ + LE +VC +K+++ V E++ +++ H
Sbjct: 2633 QLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAA--KKVGEIEDKLKKELKHLHH- 2689
Query: 393 DLAI-----KTVEEIEGVLGRDLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEELN 447
D I +T EE L RDL E++L + +EN+ LTA + S ++
Sbjct: 2690 DAGIMRNETETAEERVAELARDLV--------EMEQKLLMVTKENKGLTAQIQSFGRSMS 2741
Query: 448 RTKATMNAIREERDRLRRR----VREL-QTRLQ----------------SVQATGPSSPG 486
+ + + EE D L+R+ ++EL Q + Q S+ +T +S
Sbjct: 2742 SLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLS 2801
Query: 487 RLTSTNRPINPSTGELSTSSSSNDIPIAKI--------------------AERVKLSKTR 526
L N+ + +L SS + ++ E+ + S+
Sbjct: 2802 HLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEG 2861
Query: 527 SESSSSDRPVLGSEISSI-GVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAIS--ESKI 583
+ S++ +E+ S+ SS+ L++ N+Q+ + + + + ++++
Sbjct: 2862 KQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQL 2921
Query: 584 REFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSE 643
+E++ +T+ E L+ +N L+ E + E+ S + + L +
Sbjct: 2922 QEYQDKTKAFQIMQEELRQEN--LSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQ 2979
Query: 644 QCIEAYELL--LALAESEQSLILGQFRAAGVGSSPGDQSGDENI---TQMLKRAHDCRKT 698
Q L+ L + S+ + Q++ + G +N+ T++L R
Sbjct: 2980 QLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELL------RTQ 3033
Query: 699 AENAAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDT-EFTKEDEQ 757
++ K + K +Q S S + + CDT + +E++Q
Sbjct: 3034 LNDSLKEIHQK------------ELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQ 3081
Query: 758 RLKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAMKE 817
D L N A ++ + EL++ PL+ DV P ++ + +EL ++
Sbjct: 3082 HYGD----LLNHCAVLEKQVQELQA---GPLNIDVAPGAPQEKNGVHRKSDPEELREPQQ 3134
Query: 818 EMAELKAQLYLLEKE----KKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLS 873
+E + QL +E +K LE + R A E A V E ++ +E + R+
Sbjct: 3135 SFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENALSVAEEQIR-RLEHSEWDSSRTPI 3193
Query: 874 STSSGSKDK 882
S G++++
Sbjct: 3194 IGSCGTQEQ 3202
Score = 58.2 bits (139), Expect = 4e-08
Identities = 189/1006 (18%), Positives = 395/1006 (39%), Gaps = 115/1006 (11%)
Query: 70 EESVAEIMNQLGADENGKISFQDFTRCRMQLVREIRKEEVDLSAKSD--NSCTKKLRDRI 127
+ES E N D ++++ + + ++L IR+++V L K + K ++I
Sbjct: 36 QESDMEFNNTTQEDVQERLAYAE--QLVVELKDIIRQKDVQLQQKDEALQEERKAADNKI 93
Query: 128 ASWPTSSDNSLGALSAARESWEYDSGARDLQSPDVQSQSALQKLLEYGGSSLHQQAAL-- 185
+ L +L+ E + G + + QS+ L K + SS ++ +
Sbjct: 94 KKLKLHAKAKLTSLNKYIEEMKAQGGT--VLPTEPQSEEQLSK---HDKSSTEEEMEIEK 148
Query: 186 --HKLLTQSPHIGNSVGGSYLELANTLHSAALASLKGDIVELNKRLQQTERERDLLEKKL 243
HKL + I S + L A A ++ + V + ++LQ+ E L+ +L
Sbjct: 149 IKHKLQEKEELI--STLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQL 206
Query: 244 AKAQCEQS--HLMREHEDVQERTTLRYEERITEL---HSVIAELNKKIDRLQGTTIREED 298
++ Q EQ+ ++RE + E +E+ + +L V E+ +K+ LQ R+ +
Sbjct: 207 SQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQ----RKLE 262
Query: 299 EYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLTG 358
E+ E +Q + ++ + +Q +S Q + N + E ++L
Sbjct: 263 EHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLE 322
Query: 359 LENVVCGRKKSSCSLSVAEVDRHIEQLTTA--------SEHCDLAIKTVEEIEGVLGRDL 410
+ +K S E+ +EQ A S + L K E+E L
Sbjct: 323 KMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHIL 382
Query: 411 YPNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVREL 470
+L + + L+++N L L K E+ ++ T+ + ++ + + + +
Sbjct: 383 --SLQKTGQELQSACDALKDQNSKL---LQDKNEQAVQSAQTIQQLEDQLQQKSKEISQF 437
Query: 471 QTRL------------------QSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIP 512
RL + QA + L + G L SS +
Sbjct: 438 LNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEEL 497
Query: 513 IA---KIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQ 569
A K++ ++ L + ++ + +DR V SEIS + +++ + S QD ++ F
Sbjct: 498 KAENEKLSSQITLLEAQNRTGEADREV--SEISIVDIANKRSSSAEESGQDV--LENTFS 553
Query: 570 TLYSHGSA-ISESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKY 628
+ S + E K + E+ +L + + + + + E + E ++ + K
Sbjct: 554 QKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKV 613
Query: 629 ESNATALRLALQYSEQCIEAYELLLALAESEQSLILGQFRA--------AGVGSSPGDQS 680
T L +E E L E EQ+ Q R AGV Q
Sbjct: 614 FLEDTGQDFPLMPNE------ESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQD 667
Query: 681 GDENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAV--AGCSVQPWESLSSNSHTS 738
GD++++ + C + K+ +++L+ + A + + E + N
Sbjct: 668 GDKSLS-AVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIE 726
Query: 739 TTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDVKPRGDS 798
A + + FT E+R + Q+K +L+M+ + L ++
Sbjct: 727 EFKKNADNNSSAFTALSEER-DQLLSQVK------ELSMVTELRAQVKQLEMNLAEAERQ 779
Query: 799 QRLDLENA-----VLMQELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVH 853
+RLD E+ +L +++ ++ E ++ +L+ E ++L+ S + ++
Sbjct: 780 RRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQ 839
Query: 854 IEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKECADAASPALSLAELRTTCSENELAAEF 913
+++ +SEV E E R+R +SS + S ALS EL T + L +
Sbjct: 840 LQNKESEVLEGAE-RVRHISSK------------VEELSQALSQKELEITKMDQLLLEKK 886
Query: 914 TNAIRREKKLKARVQELV----SALERLTKSSEIRHQQSAEFVNDLKRANSNLVAAYEKA 969
+ ++ ++ + Q++ S E++ + +E + E + LK NL++ E+A
Sbjct: 887 RDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVE-IKTLKE-QLNLLSRAEEA 944
Query: 970 KKKHQNKLKKLESQMMAMVERHETQVRMLKQRIA----LLEEENSR 1011
KK+ + ++ S + + ++ K+ + LL++EN +
Sbjct: 945 KKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQ 990
Score = 56.6 bits (135), Expect = 1e-07
Identities = 111/550 (20%), Positives = 212/550 (38%), Gaps = 71/550 (12%)
Query: 62 MVCRQLNMEESVAEIMNQLGAD----ENGKISFQDFTRCRMQLVREIRKEEVDLSAK--S 115
+VC Q + V EI ++L + + ++ T + V E+ ++ V++ K
Sbjct: 2662 LVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLM 2721
Query: 116 DNSCTKKLRDRIASWPTSSDNSLGALSAARESWE-----YDSGARDLQSPDVQS-----Q 165
K L +I S+ S + + A E + YD+ ++L Q +
Sbjct: 2722 VTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRER 2781
Query: 166 SALQKLLEYGGSSLHQQAALH------KLLTQSP---HIGNSVGGSYLELANTLHSAALA 216
AL + +S + + H +LL++ H+ + + SY ++ + S A+A
Sbjct: 2782 DALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQS--FSKAMA 2839
Query: 217 SLKGDIVELNKRLQQTERERD-----------------LLEKKLAKAQCEQSHLMREHED 259
SL+ + L L++ + + L+K ++ Q ++ L++E ++
Sbjct: 2840 SLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKN 2899
Query: 260 VQERTTLRYEERITELHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSR 319
+Q++ L+ + ITELH + A+L + D+ + I +E ELR E QHE+++
Sbjct: 2900 LQQQY-LQINQEITELHPLKAQLQEYQDKTKAFQIMQE----ELRQENLSWQHELHQLRM 2954
Query: 320 SMDQDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVD 379
+ + Q M +D D + L+ L+N++ + SS +V
Sbjct: 2955 EKSSWEIHERRMKEQYLMAISDKD----------QQLSHLQNLIRELRSSSSQTQPLKVQ 3004
Query: 380 RHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPNLAEERSR------WEKELAGLREENE 433
+ S D + V E E +L L +L E + + L EE
Sbjct: 3005 YQRQASPETSASPDGSQNLVYETE-LLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKN 3063
Query: 434 SLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNR 493
+L+ LC + L + + L ++V+ELQ ++ P +P +R
Sbjct: 3064 TLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNID-VAPGAPQEKNGVHR 3122
Query: 494 PINP-STGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAE 552
+P E S S + + V + E R + +S V+
Sbjct: 3123 KSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENALS---VAEEQIR 3179
Query: 553 HLAHSLQDCS 562
L HS D S
Sbjct: 3180 RLEHSEWDSS 3189
Score = 44.7 bits (104), Expect = 5e-04
Identities = 137/834 (16%), Positives = 308/834 (36%), Gaps = 94/834 (11%)
Query: 222 IVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITELHSVIAE 281
I +L +R+ E E+ K+ ++ + + + ++ +E +T+++ + +
Sbjct: 1842 IDQLKERIAGLEEEKQK-NKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQ 1900
Query: 282 LNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTAD 341
+ +++ R+ E+E +L L E+N + QD T I +
Sbjct: 1901 IQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKN 1960
Query: 342 MDNC-SDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVE 400
+ C S+L E Q+++ V +K + + + A E +L + +
Sbjct: 1961 LKKCVSELEEEKQQLVKEKTKVESEIRKEYLE-KIQGAQKEPGNKSHAKELQELLKEKQQ 2019
Query: 401 EIEGVLGRDLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKATMNAIREER 460
E++ L ++ R++++++ L ++L + +++L TK + E R
Sbjct: 2020 EVK---------QLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHR 2070
Query: 461 DRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERV 520
+ + + + L Q+ + + + + + D + + E+
Sbjct: 2071 KKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQA 2130
Query: 521 --------KLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDC--SNIQEIFQT 570
K + + ++ ++ L I I V+ + + LQ+ S + ++
Sbjct: 2131 EEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAF 2190
Query: 571 LYSHGS-------AISESK---------IREFEVETERLNSRIEHLKSQNDLLTITLEEC 614
S S I E+K I+ E E LK Q ++I +EE
Sbjct: 2191 TKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEEL 2250
Query: 615 KSNAERMSMLVGKYESNA-TALRLALQYSEQCI-EAYELLLALAESEQSLILGQFRAAGV 672
K N R+ +ES A T ++L + + E ELL L E+ Q A +
Sbjct: 2251 KINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKL 2310
Query: 673 GSSPGDQSGDENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQPWESLS 732
S +S + +T + C++ G+ G +Q S
Sbjct: 2311 ESEL--KSLKDQLTDLSNSLEKCKEQK------------GNLEGIIRQQEADIQ--NSKF 2354
Query: 733 SNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSY-- 790
S T + + +E + + I L A+++ + EL H +
Sbjct: 2355 SYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELE 2414
Query: 791 DVKPRGDSQRLDLENA---------VLMQELMAMKEEMAELKAQLYLLEKEKKALE---- 837
++ + + + + LE LM+ L +K+E + KAQL K +L+
Sbjct: 2415 NLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRD 2474
Query: 838 -LKLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKECADAASPALS 896
+ ++ +E+ + +E K ++ ++ L G + ++ A
Sbjct: 2475 RIVGDYQQLEERHLSIILE--KDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAE 2532
Query: 897 LAELRTTCSENELAAEFTNAIRREKKLKARVQELVSALERLTKSSEIRHQQSAEFVNDLK 956
L + R E N + K ++ ++L+ + K E ++ + E + + +
Sbjct: 2533 LIQYR----------EDLNQVITIK--DSQQKQLLEVQLQQNKELENKYAKLEEKLKESE 2580
Query: 957 RANSNLVAAYEKAKKKHQNKLKKLESQMMAMVERHETQVRMLKQRIALLEEENS 1010
AN +L ++ +++ Q+ K++ES + + L +++ L+EE +
Sbjct: 2581 EANEDLRRSFNALQEEKQDLSKEIESL--------KVSISQLTRQVTALQEEGT 2626
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.123 0.325
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,698,518
Number of Sequences: 37866
Number of extensions: 1454027
Number of successful extensions: 22746
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 289
Number of HSP's successfully gapped in prelim test: 900
Number of HSP's that attempted gapping in prelim test: 14657
Number of HSP's gapped (non-prelim): 6706
length of query: 1019
length of database: 18,247,518
effective HSP length: 112
effective length of query: 907
effective length of database: 14,006,526
effective search space: 12703919082
effective search space used: 12703919082
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.