Search of human proteins with 145386551

Search of human proteins with 145386551

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|145386551 SH3 domain and tetratricopeptide repeats 1 [Homo
sapiens]
         (1336 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|145386551 SH3 domain and tetratricopeptide repeats 1 [Homo sa...  2663   0.0  
gi|38488692 SH3 domain and tetratricopeptide repeats 2 [Homo sap...   690   0.0  
gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens]         81   8e-15
gi|224548927 G-protein signaling modulator 1 (AGS3-like, C. eleg...    54   8e-07
gi|224548925 G-protein signaling modulator 1 (AGS3-like, C. eleg...    54   8e-07
gi|164519122 LGN protein [Homo sapiens]                                49   3e-05
gi|5729856 GRB2-related adaptor protein [Homo sapiens]                 38   0.057
gi|56550039 myeloid/lymphoid or mixed-lineage leukemia protein [...    38   0.074
gi|39930351 dynamin binding protein [Homo sapiens]                     38   0.074
gi|239758086 PREDICTED: similar to double homeobox, 4 [Homo sapi...    37   0.17 
gi|21493022 A kinase (PRKA) anchor protein 12 isoform 1 [Homo sa...    37   0.17 
gi|21493024 A kinase (PRKA) anchor protein 12 isoform 2 [Homo sa...    37   0.17 
gi|39930517 sterile alpha motif domain containing 1 [Homo sapiens]     36   0.22 
gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Ho...    35   0.37 
gi|120432042 vav 3 guanine nucleotide exchange factor isoform 2 ...    35   0.48 
gi|24497620 signal recognition particle 68kDa [Homo sapiens]           35   0.48 
gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1 ...    35   0.63 
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ...    34   0.82 
gi|21735550 mitogen-activated protein kinase kinase kinase 10 [H...    34   0.82 
gi|116089276 tetratricopeptide repeat domain 23-like [Homo sapiens]    34   1.1  
gi|33286446 opioid growth factor receptor [Homo sapiens]               33   1.4  
gi|194097382 ADP-ribosyltransferase 3 isoform c [Homo sapiens]         33   1.4  
gi|194097380 ADP-ribosyltransferase 3 isoform a [Homo sapiens]         33   1.4  
gi|21361167 ADP-ribosyltransferase 3 isoform b [Homo sapiens]          33   1.4  
gi|134031945 SCO-spondin [Homo sapiens]                                33   1.4  
gi|196259776 peroxisomal biogenesis factor 5 isoform d [Homo sap...    33   1.8  
gi|196259774 peroxisomal biogenesis factor 5 isoform d [Homo sap...    33   1.8  
gi|196259772 peroxisomal biogenesis factor 5 isoform c [Homo sap...    33   1.8  
gi|196259770 peroxisomal biogenesis factor 5 isoform a [Homo sap...    33   1.8  
gi|21361204 peroxisomal biogenesis factor 5 isoform b [Homo sapi...    33   1.8  

>gi|145386551 SH3 domain and tetratricopeptide repeats 1 [Homo
            sapiens]
          Length = 1336

 Score = 2663 bits (6903), Expect = 0.0
 Identities = 1336/1336 (100%), Positives = 1336/1336 (100%)

Query: 1    MENLPAVTTEEPTPMGRGPVGPSGGGSTRDQVRTVVMRPSVSWEKAGPEEAKAPVRGDEA 60
            MENLPAVTTEEPTPMGRGPVGPSGGGSTRDQVRTVVMRPSVSWEKAGPEEAKAPVRGDEA
Sbjct: 1    MENLPAVTTEEPTPMGRGPVGPSGGGSTRDQVRTVVMRPSVSWEKAGPEEAKAPVRGDEA 60

Query: 61   PPARVAGPAAGTPPCQMGVYPTDLTLQLLAVRRKSRLRDPGLQQTLRGQLRLLENDSREM 120
            PPARVAGPAAGTPPCQMGVYPTDLTLQLLAVRRKSRLRDPGLQQTLRGQLRLLENDSREM
Sbjct: 61   PPARVAGPAAGTPPCQMGVYPTDLTLQLLAVRRKSRLRDPGLQQTLRGQLRLLENDSREM 120

Query: 121  ARVLGELSARLLSIHSDQDRIVVTFKTFEEIWKFSTYHALGFTHHCLANLLMDQAFWLLL 180
            ARVLGELSARLLSIHSDQDRIVVTFKTFEEIWKFSTYHALGFTHHCLANLLMDQAFWLLL
Sbjct: 121  ARVLGELSARLLSIHSDQDRIVVTFKTFEEIWKFSTYHALGFTHHCLANLLMDQAFWLLL 180

Query: 181  PSEEEETAIQVHVDENALRLTHESLLIQEGPFFVLCPDHHVRVMTGPRDAGNGPQALRQA 240
            PSEEEETAIQVHVDENALRLTHESLLIQEGPFFVLCPDHHVRVMTGPRDAGNGPQALRQA
Sbjct: 181  PSEEEETAIQVHVDENALRLTHESLLIQEGPFFVLCPDHHVRVMTGPRDAGNGPQALRQA 240

Query: 241  SGAPQGEAAPETDSSPPSPSVSSEEVAVAAAPEPLIPFHQWALRIPQDPIDDAMGGPVMP 300
            SGAPQGEAAPETDSSPPSPSVSSEEVAVAAAPEPLIPFHQWALRIPQDPIDDAMGGPVMP
Sbjct: 241  SGAPQGEAAPETDSSPPSPSVSSEEVAVAAAPEPLIPFHQWALRIPQDPIDDAMGGPVMP 300

Query: 301  GNPLMAVGLASALADFQGSGPEEMTFRGGDLIEILGAQVPSLPWCVGRHAASGRVGFVRS 360
            GNPLMAVGLASALADFQGSGPEEMTFRGGDLIEILGAQVPSLPWCVGRHAASGRVGFVRS
Sbjct: 301  GNPLMAVGLASALADFQGSGPEEMTFRGGDLIEILGAQVPSLPWCVGRHAASGRVGFVRS 360

Query: 361  SLISMQGPVSELESAIFLNEEEKSFFSEGCFSEEDARQLLRRMSGTDVCSVYSLDSVEEA 420
            SLISMQGPVSELESAIFLNEEEKSFFSEGCFSEEDARQLLRRMSGTDVCSVYSLDSVEEA
Sbjct: 361  SLISMQGPVSELESAIFLNEEEKSFFSEGCFSEEDARQLLRRMSGTDVCSVYSLDSVEEA 420

Query: 421  ETEQPQEKEIPPPCLSPEPQETLQKVKNVLEQCKTCPGCPQEPASWGLCAASSDVSLQDP 480
            ETEQPQEKEIPPPCLSPEPQETLQKVKNVLEQCKTCPGCPQEPASWGLCAASSDVSLQDP
Sbjct: 421  ETEQPQEKEIPPPCLSPEPQETLQKVKNVLEQCKTCPGCPQEPASWGLCAASSDVSLQDP 480

Query: 481  EEPSFCLEAEDDWEDPEALSSLLLFLNAPGYKASFRGLYDVALPWLSSVFRSFSDEEELT 540
            EEPSFCLEAEDDWEDPEALSSLLLFLNAPGYKASFRGLYDVALPWLSSVFRSFSDEEELT
Sbjct: 481  EEPSFCLEAEDDWEDPEALSSLLLFLNAPGYKASFRGLYDVALPWLSSVFRSFSDEEELT 540

Query: 541  GRLAQARGAAKKAGLLMALARLCFLLGRLCSRRLKLSQARVYFEEALGALEGSFGDLFLV 600
            GRLAQARGAAKKAGLLMALARLCFLLGRLCSRRLKLSQARVYFEEALGALEGSFGDLFLV
Sbjct: 541  GRLAQARGAAKKAGLLMALARLCFLLGRLCSRRLKLSQARVYFEEALGALEGSFGDLFLV 600

Query: 601  VAVYANLASIYRKQKNREKCAQVVPKAMALLLGTPDHICSTEAEGELLQLALRRAVGGQS 660
            VAVYANLASIYRKQKNREKCAQVVPKAMALLLGTPDHICSTEAEGELLQLALRRAVGGQS
Sbjct: 601  VAVYANLASIYRKQKNREKCAQVVPKAMALLLGTPDHICSTEAEGELLQLALRRAVGGQS 660

Query: 661  LQAEARACFLLARHHVHLKQPEEALPFLERLLLLHRDSGAPEAAWLSDCYLLLADIYSRK 720
            LQAEARACFLLARHHVHLKQPEEALPFLERLLLLHRDSGAPEAAWLSDCYLLLADIYSRK
Sbjct: 661  LQAEARACFLLARHHVHLKQPEEALPFLERLLLLHRDSGAPEAAWLSDCYLLLADIYSRK 720

Query: 721  CLPHLVLSCVKVASLRTRGSLAGSLRSVNLVLQNAPQPHSLPAQTSHYLRQALASLTPGT 780
            CLPHLVLSCVKVASLRTRGSLAGSLRSVNLVLQNAPQPHSLPAQTSHYLRQALASLTPGT
Sbjct: 721  CLPHLVLSCVKVASLRTRGSLAGSLRSVNLVLQNAPQPHSLPAQTSHYLRQALASLTPGT 780

Query: 781  GQALRGPLYTSLAQLYSHHGCHGPAITFMTQAVEASAIAGVRAIVDHLVALAWLHVLHGQ 840
            GQALRGPLYTSLAQLYSHHGCHGPAITFMTQAVEASAIAGVRAIVDHLVALAWLHVLHGQ
Sbjct: 781  GQALRGPLYTSLAQLYSHHGCHGPAITFMTQAVEASAIAGVRAIVDHLVALAWLHVLHGQ 840

Query: 841  SPVALDILQSVRDAVVASEDQEGVIANMVAVALKRTGRTRQAAESYYRALRVARDLGQQR 900
            SPVALDILQSVRDAVVASEDQEGVIANMVAVALKRTGRTRQAAESYYRALRVARDLGQQR
Sbjct: 841  SPVALDILQSVRDAVVASEDQEGVIANMVAVALKRTGRTRQAAESYYRALRVARDLGQQR 900

Query: 901  NQAVGLANFGALCLHAGASRLAQHYLLEAVRLFSRLPLGECGRDFTHVLLQLGHLCTRQG 960
            NQAVGLANFGALCLHAGASRLAQHYLLEAVRLFSRLPLGECGRDFTHVLLQLGHLCTRQG
Sbjct: 901  NQAVGLANFGALCLHAGASRLAQHYLLEAVRLFSRLPLGECGRDFTHVLLQLGHLCTRQG 960

Query: 961  PAQQGKGYYEWALLVAVEMGHVESQLRAVQRLCHFYSAVMPSEAQCVIYHELQLSLACKV 1020
            PAQQGKGYYEWALLVAVEMGHVESQLRAVQRLCHFYSAVMPSEAQCVIYHELQLSLACKV
Sbjct: 961  PAQQGKGYYEWALLVAVEMGHVESQLRAVQRLCHFYSAVMPSEAQCVIYHELQLSLACKV 1020

Query: 1021 ADKVLEGQLLETISQLYLSLGTERAYKSALDYTKRSLGIFIDLQKKEKEAHAWLQAGKIY 1080
            ADKVLEGQLLETISQLYLSLGTERAYKSALDYTKRSLGIFIDLQKKEKEAHAWLQAGKIY
Sbjct: 1021 ADKVLEGQLLETISQLYLSLGTERAYKSALDYTKRSLGIFIDLQKKEKEAHAWLQAGKIY 1080

Query: 1081 YILRQSELVDLYIQVAQNVALYTGDPNLGLELFEAAGDIFFDGAWEREKAVSFYRDRALP 1140
            YILRQSELVDLYIQVAQNVALYTGDPNLGLELFEAAGDIFFDGAWEREKAVSFYRDRALP
Sbjct: 1081 YILRQSELVDLYIQVAQNVALYTGDPNLGLELFEAAGDIFFDGAWEREKAVSFYRDRALP 1140

Query: 1141 LAVTTGNRKAELRLCNKLVALLATLEEPQEGLEFAHMALALSITLGDRLNERVAYHRLAA 1200
            LAVTTGNRKAELRLCNKLVALLATLEEPQEGLEFAHMALALSITLGDRLNERVAYHRLAA
Sbjct: 1141 LAVTTGNRKAELRLCNKLVALLATLEEPQEGLEFAHMALALSITLGDRLNERVAYHRLAA 1200

Query: 1201 LQHRLGHGELAEHFYLKALSLCNSPLEFDEETLYYVKVYLVLGDIIFYDLKDPFDAAGYY 1260
            LQHRLGHGELAEHFYLKALSLCNSPLEFDEETLYYVKVYLVLGDIIFYDLKDPFDAAGYY
Sbjct: 1201 LQHRLGHGELAEHFYLKALSLCNSPLEFDEETLYYVKVYLVLGDIIFYDLKDPFDAAGYY 1260

Query: 1261 QLALAAAVDLGNKKAQLKIYTRLATIYHNFLLDREKSLFFYQKARTFATELNVRRVNLPP 1320
            QLALAAAVDLGNKKAQLKIYTRLATIYHNFLLDREKSLFFYQKARTFATELNVRRVNLPP
Sbjct: 1261 QLALAAAVDLGNKKAQLKIYTRLATIYHNFLLDREKSLFFYQKARTFATELNVRRVNLPP 1320

Query: 1321 LPLCGWAPWLAPSHPR 1336
            LPLCGWAPWLAPSHPR
Sbjct: 1321 LPLCGWAPWLAPSHPR 1336


>gi|38488692 SH3 domain and tetratricopeptide repeats 2 [Homo sapiens]
          Length = 1288

 Score =  690 bits (1780), Expect = 0.0
 Identities = 470/1261 (37%), Positives = 679/1261 (53%), Gaps = 70/1261 (5%)

Query: 83   DLTLQLLAVRRKSRLRDPGLQQTLRGQLRLLENDSREMARVLGELSARLLSIHSDQDRIV 142
            DLTL      R  R  +  LQ+  R +L  LEN+ +E+  +  +LSARL+SI S + + +
Sbjct: 51   DLTLSFCVKSRSRRCVNGPLQEAARRRLWALENEDQEVRMLFKDLSARLVSIQSQRAQFL 110

Query: 143  VTFKTFEEIWKFSTYHALGFTHHCLANLLMDQAFWLLLPSEEEETAIQVHVDENALRLTH 202
            +TFKT EEIWKFSTY  LG+   CL +LL D  +WL     E+ T IQV VD+  L   +
Sbjct: 111  ITFKTMEEIWKFSTYLNLGYVSMCLEHLLFDHKYWLNCILVED-TEIQVSVDDKHLETIY 169

Query: 203  ESLLIQEGPFF--VLCPDHHVRVMTGPRDAGNGPQAL--RQASGAPQGEAAPETDSSPPS 258
              LLIQEG FF   LC       +T P +       L   +       EA  E +    S
Sbjct: 170  LGLLIQEGHFFCRALCS------VTPPAEKEGECLTLCKNELISVKMAEAGSELEGV--S 221

Query: 259  PSVSSEEVAVAAAPEPL-IPFHQWALRIPQDPIDDAMGGPVMPGNPLMAVGLASALADFQ 317
                   + + +A EPL +PFHQW L+        +       G+  +  G   AL  ++
Sbjct: 222  LVTGQRGLVLVSALEPLPLPFHQWFLKNYPGSCGLSRKRD-WTGSYQIGRGRCKALTGYE 280

Query: 318  GSGPEEMTFRGGDLIEILGAQVPSLPWCVGRHAASGRVGFVRSSLISMQGPVSELESAIF 377
                +E+ F  G+ IEI+G  +P L W +G+  +SG+VGFV +  I          ++ F
Sbjct: 281  PGEKDELNFYQGESIEIIGFVIPGLQWFIGKSTSSGQVGFVPTRNIDPDSYSPMSRNSAF 340

Query: 378  LNEEEK-SFFSEGCFSEEDARQLLRRMSGTDVCSVYSLDSVEEAETEQPQEKEIPPPCLS 436
            L++EE+ S  + G   + +    L  ++ TD+ SVY L   E  +         PP  LS
Sbjct: 341  LSDEERCSLLALGSDKQTECSSFLHTLARTDITSVYRLSGFESIQN--------PPNDLS 392

Query: 437  PEPQETLQKVKNVLEQCKTCPGCPQEP---ASWGLCAASSDVSLQDP----EEPSFCLEA 489
                E  ++V+         PG   E          ++S D SL++        S+ L  
Sbjct: 393  ASQPEGFKEVR---------PGRAWEEHQAVGSRQSSSSEDSSLEEELLSATSDSYRLPE 443

Query: 490  EDDWEDPEALSSL--------------LLFLNAPGYKASFRGLYDVALPWLSSVFRSFSD 535
             DD +DPE L  L              L FL+  GY   F+ LYD +  +L+S F SFS+
Sbjct: 444  PDDLDDPELLMDLSTGQEEEAENFAPILAFLDHEGYADHFKSLYDFSFSFLTSSFYSFSE 503

Query: 536  EEELTGRLAQARGAAKKAGLLMALARLCFLLGRLCSRRLKLSQARVYFEEALGALEGSFG 595
            E+E    L  +R  AKK+ +  A ARLCFLLGRL  R++KLSQARVYFEEA+  L G+F 
Sbjct: 504  EDEFVAYLEASRKWAKKSHMTWAHARLCFLLGRLSIRKVKLSQARVYFEEAIHILNGAFE 563

Query: 596  DLFLVVAVYANLASIYRKQKNREKCAQVVPKAMALLLGTPDHICSTEAEGELLQLALRRA 655
            DL LV  +Y NLA+IY KQ+ R K + ++ KA ALL   PD   S + E +++   LR+ 
Sbjct: 564  DLSLVATLYINLAAIYLKQRLRHKGSALLEKAGALLACLPDRESSAKHELDVVAYVLRQG 623

Query: 656  VGGQSLQAEARACFLLARHHVHLKQPEEALPFLERLLLLHRDSGAPEAAWLSDCYLLLAD 715
            +   S   EARACFL  R  + L + EE LPF ERL LL     A EA        +L+ 
Sbjct: 624  IVVGSSPLEARACFLAIRLLLSLGRHEEVLPFAERLQLLSGHPPASEAV-----ASVLSF 678

Query: 716  IYSRKCLPHLVLSCVKVASLRTRGSLAGSLRSVNLVLQNAPQPHSLP--------AQTSH 767
            +Y +K LPHL ++ V+   +++   ++  +  V+LVLQN  +    P        A    
Sbjct: 679  LYDKKYLPHLAVASVQQHGIQSAQGMSLPIWQVHLVLQNTTKLLGFPSPGWGEVSALACP 738

Query: 768  YLRQALASLTPGTGQALRGPLYTSLAQLYSHHGCHGPAITFMTQAVEASAIAGVRAIVDH 827
             LRQALA+      ++ +  L   L+++Y  H     AI +++QA+    + G +   + 
Sbjct: 739  MLRQALAACEELADRSTQRALCLILSKVYLEHRSPDGAIHYLSQALVLGQLLGEQESFES 798

Query: 828  LVALAWLHVLHGQSPVALDILQSVRDAVVASED--QEGVIANMVAVALKRTGRTRQAAES 885
             + LAW ++L  Q+  ALD+L+ +  ++  +E   Q GVI N++ +AL+  GR  +AA+S
Sbjct: 799  SLCLAWAYLLASQAKKALDVLEPLLCSLKETESLTQRGVIYNLLGLALQGEGRVNRAAKS 858

Query: 886  YYRALRVARDLGQQRNQAVGLANFGALCLHAGASRLAQHYLLEAVRLFSRLPLG-ECGRD 944
            Y RAL  A+++G   NQAV +AN G L L + A   A++YLL+AVRL+  L    E   +
Sbjct: 859  YLRALNRAQEVGDVHNQAVAMANLGHLSLKSWAQHPARNYLLQAVRLYCELQASKETDME 918

Query: 945  FTHVLLQLGHLCTRQGPAQQGKGYYEWALLVAVEMGHVESQLRAVQRLCHFYSAVMPSEA 1004
               V L L  +         G   YE ALL  +   H++SQL+A + LCHFYS+V P+  
Sbjct: 919  LVQVFLWLAQVLVSGHQLTHGLLCYEMALLFGLRHRHLKSQLQATKSLCHFYSSVSPNPE 978

Query: 1005 QCVIYHELQLSLACKVADKVLEGQLLETISQLYLSLGTERAYKSALDYTKRSLGIFIDLQ 1064
             C+ YHE  L+LA ++ D+ +EG+LLE++ QLY +L T R+ + +L   K SL IFIDL 
Sbjct: 979  ACITYHEHWLALAQQLRDREMEGRLLESLGQLYRNLNTARSLRRSLTCIKESLRIFIDLG 1038

Query: 1065 KKEKEAHAWLQAGKIYYILRQSELVDLYIQVAQNVALYTGDPNLGLELFEAAGDIFFDGA 1124
            + +K A AWL AG+++Y++++ ELV+L +Q A   AL + +P L L+L+E AGD+FF+G 
Sbjct: 1039 ETDKAAEAWLGAGRLHYLMQEDELVELCLQAAIQTALKSEEPLLALKLYEEAGDVFFNGT 1098

Query: 1125 WEREKAVSFYRDRALPLAVTTGNRKAELRLCNKLVALLATLEEPQEGLEFAHMALALSIT 1184
              R  AV +YR  A+PLA      + ELR+ NKL  L  +LE  ++ LEFA +A  LS  
Sbjct: 1099 RHRHHAVEYYRAGAVPLARRLKAVRTELRIFNKLTELQISLEGYEKALEFATLAARLSTV 1158

Query: 1185 LGDRLNERVAYHRLAALQHRLGHGELAEHFYLKALSLCNSPLEFDEETLYYVKVYLVLGD 1244
             GD+  E VA+HRLA + + L   E+AE  YLK LSLC   L+  +E LYY KVY  LG 
Sbjct: 1159 TGDQRQELVAFHRLATVYYSLHMYEMAEDCYLKTLSLCPPWLQSPKEALYYAKVYYRLGR 1218

Query: 1245 IIFYDLKDPFDAAGYYQLALAAAVDLGNKKAQLKIYTRLATIYHNFLLDREKSLFFYQKA 1304
            + F  LKD  DA  Y+ LALAAAV LG+++ Q  I +RL  I  + L     S    ++A
Sbjct: 1219 LTFCQLKDAHDATEYFLLALAAAVLLGDEELQDTIRSRLDNICQSPLWHSRPSGCSSERA 1278

Query: 1305 R 1305
            R
Sbjct: 1279 R 1279


>gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens]
          Length = 2481

 Score = 80.9 bits (198), Expect = 8e-15
 Identities = 136/610 (22%), Positives = 242/610 (39%), Gaps = 73/610 (11%)

Query: 730  VKVASLRTRGSLAGSLRSVNLVLQNAPQPHSLPAQTSHYLRQALASLTPGTGQALRGPLY 789
            +   SL+ RGS+  +L S    L N  +       ++ Y++Q L        Q      +
Sbjct: 225  IGTCSLKLRGSVFSALSSAYWSLGNTEK-------STGYMQQDLDVAKTLGDQTGECRAH 277

Query: 790  TSLAQLYSHHGCHGPAIT-FMTQAVEASAIAGVRAIVDHLVALAWLHVLHGQSPVALD-- 846
             +L   +   G +  A+T    Q V A  +    A    L +L  ++   G  P AL   
Sbjct: 278  GNLGSAFFSKGNYREALTNHRHQLVLAMKLKDREAASSALSSLGHVYTAIGDYPNALASH 337

Query: 847  ---ILQSVRDAVVASEDQEGVIANMVAVALKRTGRTRQAAESYYRALRVARDLGQQRNQA 903
               +L + +     SE +E  + NM AV +   G    A + + + L++A+DLG +R +A
Sbjct: 338  KQCVLLAKQSKDELSEARE--LGNMGAVYIAM-GDFENAVQCHEQHLKIAKDLGNKREEA 394

Query: 904  VGLANFG-----------ALCLHAGASRLAQHYLLEAVRLFSRLPLGECGRDFTHVLLQL 952
               +N G           A+  H     LAQ  + +A+ + +   LG   R         
Sbjct: 395  RAYSNLGSAYHYRRNFDKAMSYHNYVLELAQELMEKAIEMRAYAGLGHAAR--------- 445

Query: 953  GHLCTRQGPAQQGKGYYEWALLVAVEM------GHVESQLRAVQRLCHFYSAVMPSEAQC 1006
               C +    ++ K Y+E  L +A ++      G   S L  + ++   Y   +      
Sbjct: 446  ---CMQD--LERAKQYHEQQLGIAEDLKDRAAEGRASSNLGIIHQMKGDYDTALK----- 495

Query: 1007 VIYHELQLSLACKVADKVLEGQLLETISQLYLSLGTERAYKSALDYTKRSLGIFIDLQKK 1066
               H+  L +A +++D   +G+    +   Y +LG    Y  A+ Y ++ L I +++  +
Sbjct: 496  --LHKTHLCIAQELSDYAAQGRAYGNMGNAYNALGM---YDQAVKYHRQELQISMEVNDR 550

Query: 1067 EKEAHAWLQAGKIYYILRQSELVDLYIQVAQNVALYTGDPNLGLELFEAAGDIFFDGAWE 1126
              +A         Y  L   +    + Q   N+A    D           G+ F     E
Sbjct: 551  ASQASTHGNLAVAYQALGAHDRALQHYQNHLNIARELRDIQSEARALSNLGN-FHCSRGE 609

Query: 1127 REKAVSFYRDRALPLAVTTGNRKAELRLCNKLVALLATLEEPQEGLEFAHMALALSITLG 1186
              +A  +Y ++ L LA    + + E ++C+ L      L   QE +++    LAL+  L 
Sbjct: 610  YVQAAPYY-EQYLRLAPDLQDMEGEGKVCHNLGYAHYCLGNYQEAVKYYEQDLALAKDLH 668

Query: 1187 DRLNERVAYHRLA----ALQHRLGHGELAEHFYLKALSLCNSPLEFDEETLYYVKVYLVL 1242
            D+L++  AY  L     AL +     E  ++    A SL NS  +F        +    L
Sbjct: 669  DKLSQAKAYCNLGLAFKALLNFSKAEECQKYLLSLAQSLNNSQAKF--------RALGNL 720

Query: 1243 GDIIFYDLKDPFDAAGYYQLALAAAVDLGNKKAQLKIYTRLATIYHNFLLDREKSLFFYQ 1302
            GD IF   KD   A  +Y+  L  A  + +++ +   Y  L T Y   +   +K+L ++ 
Sbjct: 721  GD-IFICKKDINGAIKFYEQQLGLAHQVKDRRLEASAYAALGTAY-RMIQKYDKALGYHT 778

Query: 1303 KARTFATELN 1312
            +      EL+
Sbjct: 779  QELEVYQELS 788



 Score = 58.5 bits (140), Expect = 4e-08
 Identities = 103/488 (21%), Positives = 188/488 (38%), Gaps = 44/488 (9%)

Query: 838  HGQSPVALDILQSVRDAVVASEDQEGVIANMVAVALKRTGRTRQAAESYYRALRVARDLG 897
            HG S V L+    +      S    G + + ++ A    G T ++     + L VA+ LG
Sbjct: 212  HGASVVVLEAALKIG---TCSLKLRGSVFSALSSAYWSLGNTEKSTGYMQQDLDVAKTLG 268

Query: 898  QQRNQAVGLANFGALCLHAGASRLA----QHYLLEAVRLFSRLPLGECGRDFTHVLLQLG 953
             Q  +     N G+     G  R A    +H L+ A++L  R          +  L  LG
Sbjct: 269  DQTGECRAHGNLGSAFFSKGNYREALTNHRHQLVLAMKLKDR-------EAASSALSSLG 321

Query: 954  HLCTRQGPAQQGKGYYEWALLVAVEMGHVESQLRAVQRLCHFYSAVMPSEAQCVIYHELQ 1013
            H+ T  G        ++  +L+A +     S+ R +  +   Y A+   E   V  HE  
Sbjct: 322  HVYTAIGDYPNALASHKQCVLLAKQSKDELSEARELGNMGAVYIAMGDFE-NAVQCHEQH 380

Query: 1014 LSLACKVADKVLEGQLLETISQLYLSLGTERAYKSALDYTKRSLGIFIDLQKKEKEAHAW 1073
            L +A  + +K  E +    +   Y      R +  A+ Y    L +  +L +K  E  A+
Sbjct: 381  LKIAKDLGNKREEARAYSNLGSAY---HYRRNFDKAMSYHNYVLELAQELMEKAIEMRAY 437

Query: 1074 LQAGKIYYILRQSELVDLYIQVAQNVALYTGD--------PNLGLELFEAAGDIFFDGAW 1125
               G     ++  E    Y +    +A    D         NLG+ + +  GD  +D A 
Sbjct: 438  AGLGHAARCMQDLERAKQYHEQQLGIAEDLKDRAAEGRASSNLGI-IHQMKGD--YDTAL 494

Query: 1126 EREKAVSFYRDRALPLAVTTGNRKAELRLCNKLVALLATLEEPQEGLEFAHMALALSITL 1185
            +  K         L +A    +  A+ R    +      L    + +++    L +S+ +
Sbjct: 495  KLHKT-------HLCIAQELSDYAAQGRAYGNMGNAYNALGMYDQAVKYHRQELQISMEV 547

Query: 1186 GDRLNERVAYHRLAALQHRLGHGELAEHFYLKALSLCNSPLEFDEETLYYVKVYLVLGDI 1245
             DR ++   +  LA     LG  + A   Y   L++     +   E     +    LG+ 
Sbjct: 548  NDRASQASTHGNLAVAYQALGAHDRALQHYQNHLNIARELRDIQSE----ARALSNLGN- 602

Query: 1246 IFYDLKDPF-DAAGYYQLALAAAVDLGNKKAQLKIYTRLATIYHNFLLDREKSLFFYQKA 1304
             F+  +  +  AA YY+  L  A DL + + + K+   L    H  L + ++++ +Y++ 
Sbjct: 603  -FHCSRGEYVQAAPYYEQYLRLAPDLQDMEGEGKVCHNLG-YAHYCLGNYQEAVKYYEQD 660

Query: 1305 RTFATELN 1312
               A +L+
Sbjct: 661  LALAKDLH 668



 Score = 54.7 bits (130), Expect = 6e-07
 Identities = 111/529 (20%), Positives = 195/529 (36%), Gaps = 102/529 (19%)

Query: 869  VAVALKRTGRTRQAAESYYRALRVARDLGQQRNQAVGLANFGALCLHAGASRLAQHYLLE 928
            +AVA +  G   +A + Y   L +AR+L   +++A  L+N G      G    A  Y  +
Sbjct: 560  LAVAYQALGAHDRALQHYQNHLNIARELRDIQSEARALSNLGNFHCSRGEYVQAAPYYEQ 619

Query: 929  AVRLFSRLPLGECGRDFTHVLLQLGHLCTRQGPAQQGKGYYEWALLVAVEMGHVESQLRA 988
             +RL   L   E      H L    H C   G  Q+   YYE  L +A ++    SQ +A
Sbjct: 620  YLRLAPDLQDMEGEGKVCHNL-GYAHYCL--GNYQEAVKYYEQDLALAKDLHDKLSQAKA 676

Query: 989  VQRLCHFYSAVMP--------------------SEAQ-------------------CVIY 1009
               L   + A++                     S+A+                    + +
Sbjct: 677  YCNLGLAFKALLNFSKAEECQKYLLSLAQSLNNSQAKFRALGNLGDIFICKKDINGAIKF 736

Query: 1010 HELQLSLACKVADKVLEGQLLETISQLYLSLGTERAYKSALDYTKRSLGIFIDLQKKEKE 1069
            +E QL LA +V D+ LE      +   Y  +   + Y  AL Y  + L ++ +L     E
Sbjct: 737  YEQQLGLAHQVKDRRLEASAYAALGTAYRMI---QKYDKALGYHTQELEVYQELSDLPGE 793

Query: 1070 AHAWLQAGKIYYILRQSELVDLYIQVAQNVALYTGDPNLGLELFEAAGDIFFDGAWEREK 1129
              A      +Y  L +  +     +   ++     DP+L  +++   G I        E+
Sbjct: 794  CRAHGHLAAVYMALGKYTMAFKCYEEQLDLGQKLKDPSLEAQVYGNMG-ITKMNMNVMEE 852

Query: 1130 AVSFYRDRALPLAVTTGNRKA----------------------ELRLCNKLVALLATLEE 1167
            A+ ++  +   L   +GN                          ++   + +++  +L  
Sbjct: 853  AIGYFEQQLAMLQQLSGNESVLDRGRAYGNLGDCYEALGDYEEAIKYYEQYLSVAQSLNR 912

Query: 1168 PQE------GLEFAHMA--------------LALSITLGDRLNERVAYHRLAALQHRLGH 1207
             Q+      GL   H A              L ++  LG+  N+  AY  L +L  +LG+
Sbjct: 913  MQDQAKAYRGLGNGHRAMGSLQQALVCFEKRLVVAHELGEAFNKAQAYGELGSLHSQLGN 972

Query: 1208 GELAEHFYLKALSLC----NSPLEFDEETLYYVKVYLVLGDIIFYDLKDPFDAAGYYQLA 1263
             E A     + L++     +  LE D        VY  +G+   YD      A  Y+QL 
Sbjct: 973  YEQAISCLERQLNIARDMKDRALESD-AACGLGGVYQQMGE---YD-----TALQYHQLD 1023

Query: 1264 LAAAVDLGNKKAQLKIYTRLATIYHNFLLDREKSLFFYQKARTFATELN 1312
            L  A +  N   Q + Y  L   Y + L   E+++ + ++  + A ++N
Sbjct: 1024 LQIAEETNNPTCQGRAYGNLGLTYES-LGTFERAVVYQEQHLSIAAQMN 1071



 Score = 44.7 bits (104), Expect = 6e-04
 Identities = 67/353 (18%), Positives = 125/353 (35%), Gaps = 46/353 (13%)

Query: 869  VAVALKRTGRTRQAAESYYRALRVARDLGQQRNQAVGLANFGALCLHAGASRLAQHYLLE 928
            +A      G+   A + Y   L + + L     +A    N G   ++      A  Y  +
Sbjct: 800  LAAVYMALGKYTMAFKCYEEQLDLGQKLKDPSLEAQVYGNMGITKMNMNVMEEAIGYFEQ 859

Query: 929  AVRLFSRLPLGECGRDFTHVLLQLGHLCTRQGPAQQGKGYYEWALLVAVEMGHVESQLRA 988
             + +  +L   E   D       LG      G  ++   YYE  L VA  +  ++ Q +A
Sbjct: 860  QLAMLQQLSGNESVLDRGRAYGNLGDCYEALGDYEEAIKYYEQYLSVAQSLNRMQDQAKA 919

Query: 989  VQRLCHFYSAVMPSEAQCVIYHELQLSLACKVADKVLEGQLLETISQLYLSLGTERAYKS 1048
             + L + + A M S  Q ++  E +L +A ++ +   + Q    +  L+  LG    Y+ 
Sbjct: 920  YRGLGNGHRA-MGSLQQALVCFEKRLVVAHELGEAFNKAQAYGELGSLHSQLGN---YEQ 975

Query: 1049 ALDYTKRSLGIFIDLQKKEKEAHAWLQAGKIYYILRQSELVDLYIQVAQNVALYTGDPNL 1108
            A+   +R L I  D++ +  E+ A    G +Y  + +                       
Sbjct: 976  AISCLERQLNIARDMKDRALESDAACGLGGVYQQMGE----------------------- 1012

Query: 1109 GLELFEAAGDIFFDGAWEREKAVSFYRDRALPLAVTTGNRKAELRLCNKLVALLATLEEP 1168
                        +D A +       Y    L +A  T N   + R    L     +L   
Sbjct: 1013 ------------YDTALQ-------YHQLDLQIAEETNNPTCQGRAYGNLGLTYESLGTF 1053

Query: 1169 QEGLEFAHMALALSITLGDRLNERVAYHRLAALQHRLGHGELAEHFYLKALSL 1221
            +  + +    L+++  + D   + V+Y  L    H L +   A  +  + L L
Sbjct: 1054 ERAVVYQEQHLSIAAQMNDLAAKTVSYSSLGRTHHALQNYSQAVMYLQEGLRL 1106



 Score = 40.4 bits (93), Expect = 0.011
 Identities = 47/200 (23%), Positives = 82/200 (41%), Gaps = 19/200 (9%)

Query: 877  GRTRQAAESYYRALRVARDLGQQRNQAVGLANFGALCLHAGASRLAQHYLLEAVRLFSRL 936
            G  +QA   + + L VA +LG+  N+A      G+L    G    A   L   + +    
Sbjct: 931  GSLQQALVCFEKRLVVAHELGEAFNKAQAYGELGSLHSQLGNYEQAISCLERQLNI---- 986

Query: 937  PLGECGRDFTHVLLQ------LGHLCTRQGPAQQGKGYYEWALLVAVEMGHVESQLRAVQ 990
                  RD     L+      LG +  + G       Y++  L +A E  +   Q RA  
Sbjct: 987  -----ARDMKDRALESDAACGLGGVYQQMGEYDTALQYHQLDLQIAEETNNPTCQGRAYG 1041

Query: 991  RLCHFYSAVMPSEAQCVIYHELQLSLACKVADKVLEGQLLETISQLYLSLGTERAYKSAL 1050
             L   Y ++   E + V+Y E  LS+A ++ D   +     ++ + + +L   + Y  A+
Sbjct: 1042 NLGLTYESLGTFE-RAVVYQEQHLSIAAQMNDLAAKTVSYSSLGRTHHAL---QNYSQAV 1097

Query: 1051 DYTKRSLGIFIDLQKKEKEA 1070
             Y +  L +   L ++E EA
Sbjct: 1098 MYLQEGLRLAEQLGRREDEA 1117



 Score = 35.4 bits (80), Expect = 0.37
 Identities = 31/111 (27%), Positives = 47/111 (42%), Gaps = 12/111 (10%)

Query: 838  HGQSPVALDILQSVRDAVVASEDQEGVIANMVAVALKRT-----GRTRQAAESYYRA--- 889
            +G   +  + L +   AVV  E    + A M  +A K       GRT  A ++Y +A   
Sbjct: 1040 YGNLGLTYESLGTFERAVVYQEQHLSIAAQMNDLAAKTVSYSSLGRTHHALQNYSQAVMY 1099

Query: 890  ----LRVARDLGQQRNQAVGLANFGALCLHAGASRLAQHYLLEAVRLFSRL 936
                LR+A  LG++ ++A      G     +G    AQH L  A  LF  +
Sbjct: 1100 LQEGLRLAEQLGRREDEAKIRHGLGLSLWASGNLEEAQHQLYRASALFETI 1150


>gi|224548927 G-protein signaling modulator 1 (AGS3-like, C. elegans)
            isoform a [Homo sapiens]
          Length = 675

 Score = 54.3 bits (129), Expect = 8e-07
 Identities = 76/293 (25%), Positives = 115/293 (39%), Gaps = 31/293 (10%)

Query: 929  AVRLFSRLPLGECGRDFTHVLLQLGHLCTRQGPAQQGKGYYEWALLVAVEMGHVESQLRA 988
            A RL+SR+    C      + L+   LC + G  + G  ++E A+ V  E     S + +
Sbjct: 17   ARRLYSRME-ASC----LELALEGERLC-KAGDFKTGVAFFEAAVQVGTEDLKTLSAIYS 70

Query: 989  VQRLCHFYSAVMPSEAQCVIYHELQLSLACKVADKVLEGQLLETISQLYLSLGTERAYKS 1048
                 +FY   +    + + YH+  L LA  + D++ E +    +      LG    +  
Sbjct: 71   QLGNAYFY---LKEHGRALEYHKHDLLLARTIGDRMGEAKASGNLGNTLKVLGR---FDE 124

Query: 1049 ALDYTKRSLGIFIDLQKKEKEAHAWLQAGKIYYILRQSELVDLYIQVAQNVALYTGDPNL 1108
            A    +R L I  +   K  EA A    G +Y+   +        Q++ N A  T DP  
Sbjct: 125  AAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHAKGK--------QLSWNAANATQDP-- 174

Query: 1109 GLELFEAAGDIFFDGAWEREKAVSFYRDRALPLAVTTGNRKAELRLCNKLVALLATLEEP 1168
                    G +  D      KA  FY +R L L    G+R A+ R    L      L   
Sbjct: 175  --------GHLPPDVRETLCKASEFY-ERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNF 225

Query: 1169 QEGLEFAHMALALSITLGDRLNERVAYHRLAALQHRLGHGELAEHFYLKALSL 1221
             E   F    LA++   GD+  ER AY  L      LG  ++A  +Y K L L
Sbjct: 226  TEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQL 278



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 77/334 (23%), Positives = 128/334 (38%), Gaps = 66/334 (19%)

Query: 873  LKRTGRTRQAAESYYRALRVARDLGQQRNQAVGLANFGALCLHAGASRLAQHYLLEAVRL 932
            LK  GR  +AA    R L +A++ G +  +A  L N G +  HA   +L+ +    A + 
Sbjct: 116  LKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNV-YHAKGKQLSWN-AANATQD 173

Query: 933  FSRLPLGECGRDFTHVLLQLGHLCTRQGPAQQGKGYYEWALLVAVEMGHVESQLRAVQRL 992
               LP      D    L +                +YE  L +  E+G   +Q RA   L
Sbjct: 174  PGHLP-----PDVRETLCKASE-------------FYERNLSLVKELGDRAAQGRAYGNL 215

Query: 993  CHFYSAVMPSEAQCVIYHELQLSLACKVADKVLEGQLLETISQLYLSLGTERAYKSALDY 1052
             + +  ++ +  +   +H+ +L++A +  DK  E +    +   ++ LG    +  A +Y
Sbjct: 216  GNTHY-LLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGR---FDVAAEY 271

Query: 1053 TKRSLGIFIDLQKKEKEAHAWLQAGKIYYILRQSELVDLYIQVAQNVALYTGDPNLGLEL 1112
             K++L +   L+ +  EA A    G  Y +L+                            
Sbjct: 272  YKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQD--------------------------- 304

Query: 1113 FEAAGDIFFDGAWEREKAVSFYRDRALPLAVTTGNRKAELRLCNKLVALLATLEEPQEGL 1172
            +E A +               Y  R L +A    +R  E R C  L     ++  P + L
Sbjct: 305  YERAAE---------------YHLRHLLIAQELADRVGEGRACWSLGNAYVSMGRPAQAL 349

Query: 1173 EFAHMALALSITLGDRLNERVAYHRLAALQHRLG 1206
             FA   L +S  +GDR  E  A   +A LQ  LG
Sbjct: 350  TFAKKHLQISQEIGDRHGELTARMNVAQLQLVLG 383


>gi|224548925 G-protein signaling modulator 1 (AGS3-like, C. elegans)
            isoform b [Homo sapiens]
          Length = 457

 Score = 54.3 bits (129), Expect = 8e-07
 Identities = 76/293 (25%), Positives = 115/293 (39%), Gaps = 31/293 (10%)

Query: 929  AVRLFSRLPLGECGRDFTHVLLQLGHLCTRQGPAQQGKGYYEWALLVAVEMGHVESQLRA 988
            A RL+SR+    C      + L+   LC + G  + G  ++E A+ V  E     S + +
Sbjct: 17   ARRLYSRME-ASC----LELALEGERLC-KAGDFKTGVAFFEAAVQVGTEDLKTLSAIYS 70

Query: 989  VQRLCHFYSAVMPSEAQCVIYHELQLSLACKVADKVLEGQLLETISQLYLSLGTERAYKS 1048
                 +FY   +    + + YH+  L LA  + D++ E +    +      LG    +  
Sbjct: 71   QLGNAYFY---LKEHGRALEYHKHDLLLARTIGDRMGEAKASGNLGNTLKVLGR---FDE 124

Query: 1049 ALDYTKRSLGIFIDLQKKEKEAHAWLQAGKIYYILRQSELVDLYIQVAQNVALYTGDPNL 1108
            A    +R L I  +   K  EA A    G +Y+   +        Q++ N A  T DP  
Sbjct: 125  AAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHAKGK--------QLSWNAANATQDP-- 174

Query: 1109 GLELFEAAGDIFFDGAWEREKAVSFYRDRALPLAVTTGNRKAELRLCNKLVALLATLEEP 1168
                    G +  D      KA  FY +R L L    G+R A+ R    L      L   
Sbjct: 175  --------GHLPPDVRETLCKASEFY-ERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNF 225

Query: 1169 QEGLEFAHMALALSITLGDRLNERVAYHRLAALQHRLGHGELAEHFYLKALSL 1221
             E   F    LA++   GD+  ER AY  L      LG  ++A  +Y K L L
Sbjct: 226  TEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQL 278



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 77/334 (23%), Positives = 128/334 (38%), Gaps = 66/334 (19%)

Query: 873  LKRTGRTRQAAESYYRALRVARDLGQQRNQAVGLANFGALCLHAGASRLAQHYLLEAVRL 932
            LK  GR  +AA    R L +A++ G +  +A  L N G +  HA   +L+ +    A + 
Sbjct: 116  LKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNV-YHAKGKQLSWN-AANATQD 173

Query: 933  FSRLPLGECGRDFTHVLLQLGHLCTRQGPAQQGKGYYEWALLVAVEMGHVESQLRAVQRL 992
               LP      D    L +                +YE  L +  E+G   +Q RA   L
Sbjct: 174  PGHLP-----PDVRETLCKASE-------------FYERNLSLVKELGDRAAQGRAYGNL 215

Query: 993  CHFYSAVMPSEAQCVIYHELQLSLACKVADKVLEGQLLETISQLYLSLGTERAYKSALDY 1052
             + +  ++ +  +   +H+ +L++A +  DK  E +    +   ++ LG    +  A +Y
Sbjct: 216  GNTHY-LLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGR---FDVAAEY 271

Query: 1053 TKRSLGIFIDLQKKEKEAHAWLQAGKIYYILRQSELVDLYIQVAQNVALYTGDPNLGLEL 1112
             K++L +   L+ +  EA A    G  Y +L+                            
Sbjct: 272  YKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQD--------------------------- 304

Query: 1113 FEAAGDIFFDGAWEREKAVSFYRDRALPLAVTTGNRKAELRLCNKLVALLATLEEPQEGL 1172
            +E A +               Y  R L +A    +R  E R C  L     ++  P + L
Sbjct: 305  YERAAE---------------YHLRHLLIAQELADRVGEGRACWSLGNAYVSMGRPAQAL 349

Query: 1173 EFAHMALALSITLGDRLNERVAYHRLAALQHRLG 1206
             FA   L +S  +GDR  E  A   +A LQ  LG
Sbjct: 350  TFAKKHLQISQEIGDRHGELTARMNVAQLQLVLG 383


>gi|164519122 LGN protein [Homo sapiens]
          Length = 684

 Score = 48.9 bits (115), Expect = 3e-05
 Identities = 74/343 (21%), Positives = 127/343 (37%), Gaps = 63/343 (18%)

Query: 881  QAAESYYRALRVARDLGQQRNQAVGLANFGALCLHAG----ASRLAQHYLLEAVRLFSRL 936
            +A E ++  L +AR +G Q  +A    N G      G    A    Q +L  +  L  ++
Sbjct: 80   KALEYHHHDLTLARTIGDQLGEAKASGNLGNTLKVLGNFDEAIVCCQRHLDISRELNDKV 139

Query: 937  PLGECGRDFTHVLLQLGHLCTRQGPAQQGK-------------GYYEWALLVAVEMGHVE 983
                   +  +V    G      GP   G+              +YE  L +   +G   
Sbjct: 140  GEARALYNLGNVYHAKGKSFGCPGPQDVGEFPEEVRDALQAAVDFYEENLSLVTALGDRA 199

Query: 984  SQLRAVQRLCHFYSAVMPSEAQCVIYHELQLSLACKVADKVLEGQLLETISQLYLSLGTE 1043
            +Q RA   L + +  ++ +    VI HE +L +A +  DK  E +    +   Y+ LG  
Sbjct: 200  AQGRAFGNLGNTHY-LLGNFRDAVIAHEQRLLIAKEFGDKAAERRAYSNLGNAYIFLGE- 257

Query: 1044 RAYKSALDYTKRSLGIFIDLQKKEKEAHAWLQAGKIYYILRQSELVDLYIQVAQNVALYT 1103
              +++A +Y K++L +   L+ +  EA +    G  Y +L+                   
Sbjct: 258  --FETASEYYKKTLLLARQLKDRAVEAQSCYSLGNTYTLLQ------------------- 296

Query: 1104 GDPNLGLELFEAAGDIFFDGAWEREKAVSFYRDRALPLAVTTGNRKAELRLCNKLVALLA 1163
                                  + EKA+ ++  + L +A    +R  E R C  L     
Sbjct: 297  ----------------------DYEKAIDYHL-KHLAIAQELNDRIGEGRACWSLGNAYT 333

Query: 1164 TLEEPQEGLEFAHMALALSITLGDRLNERVAYHRLAALQHRLG 1206
             L    + + FA   L +S  +GD+  E  A   L+ LQ  LG
Sbjct: 334  ALGNHDQAMHFAEKHLEISREVGDKSGELTARLNLSDLQMVLG 376



 Score = 45.8 bits (107), Expect = 3e-04
 Identities = 49/235 (20%), Positives = 96/235 (40%), Gaps = 21/235 (8%)

Query: 1005 QCVIYHELQLSLACKVADKVLEGQLLETISQLYLSLG-----------------TERAYK 1047
            + ++  +  L ++ ++ DKV E + L  +  +Y + G                    A +
Sbjct: 120  EAIVCCQRHLDISRELNDKVGEARALYNLGNVYHAKGKSFGCPGPQDVGEFPEEVRDALQ 179

Query: 1048 SALDYTKRSLGIFIDLQKKEKEAHAWLQAGKIYYILRQSELVDLYIQVAQNVALYTGDPN 1107
            +A+D+ + +L +   L  +  +  A+   G  +Y+L       +  +    +A   GD  
Sbjct: 180  AAVDFYEENLSLVTALGDRAAQGRAFGNLGNTHYLLGNFRDAVIAHEQRLLIAKEFGDKA 239

Query: 1108 LGLELFEAAGDIF-FDGAWEREKAVSFYRDRALPLAVTTGNRKAELRLCNKLVALLATLE 1166
                 +   G+ + F G +E     S Y  + L LA    +R  E + C  L      L+
Sbjct: 240  AERRAYSNLGNAYIFLGEFE---TASEYYKKTLLLARQLKDRAVEAQSCYSLGNTYTLLQ 296

Query: 1167 EPQEGLEFAHMALALSITLGDRLNERVAYHRLAALQHRLGHGELAEHFYLKALSL 1221
            + ++ +++    LA++  L DR+ E  A   L      LG+ + A HF  K L +
Sbjct: 297  DYEKAIDYHLKHLAIAQELNDRIGEGRACWSLGNAYTALGNHDQAMHFAEKHLEI 351



 Score = 42.4 bits (98), Expect = 0.003
 Identities = 77/362 (21%), Positives = 124/362 (34%), Gaps = 74/362 (20%)

Query: 953  GHLCTRQGPAQQGKGYYEWALLVAVEMGHVESQLRAVQRLCHFYSAVMPSEAQCVIYHEL 1012
            G    + G  + G  ++E A+ V  E     S + +     +FY   +   A+ + YH  
Sbjct: 31   GERLCKSGDCRAGVSFFEAAVQVGTEDLKTLSAIYSQLGNAYFY---LHDYAKALEYHHH 87

Query: 1013 QLSLACKVADKVLEGQLLETISQLYLSLGTERAYKSALDYTKRSLGIFIDLQKKEKEAHA 1072
             L+LA  + D++ E +    +      LG    +  A+   +R L I  +L  K  EA A
Sbjct: 88   DLTLARTIGDQLGEAKASGNLGNTLKVLGN---FDEAIVCCQRHLDISRELNDKVGEARA 144

Query: 1073 WLQAGKIYYILRQSELVDLYIQVAQNVALYTGDPNLGLELFEAAGDIFFDGAWEREKAVS 1132
                G +Y+              A+  +     P    E  E   D         + AV 
Sbjct: 145  LYNLGNVYH--------------AKGKSFGCPGPQDVGEFPEEVRDAL-------QAAVD 183

Query: 1133 FYRDRALPLAVTTGNRKAELRLCNKLVALLATLEEPQEGLEFAHMALALSITLGDRLNER 1192
            FY +  L L    G+R A+ R    L      L   ++ +      L ++   GD+  ER
Sbjct: 184  FYEEN-LSLVTALGDRAAQGRAFGNLGNTHYLLGNFRDAVIAHEQRLLIAKEFGDKAAER 242

Query: 1193 VAYHRLAALQHRLGHGELAEHFYLKALSLCNSPLEFDEETLYYVKVYLVLGDIIFYDLKD 1252
             AY  L                                        Y+ LG+        
Sbjct: 243  RAYSNLG-------------------------------------NAYIFLGEFE------ 259

Query: 1253 PFDAAGYYQLALAAAVDLGNKKAQLKIYTRLATIYHNFLLDREKSLFFYQKARTFATELN 1312
               A+ YY+  L  A  L ++  + +    L   Y   L D EK++ ++ K    A ELN
Sbjct: 260  --TASEYYKKTLLLARQLKDRAVEAQSCYSLGNTY-TLLQDYEKAIDYHLKHLAIAQELN 316

Query: 1313 VR 1314
             R
Sbjct: 317  DR 318


>gi|5729856 GRB2-related adaptor protein [Homo sapiens]
          Length = 217

 Score = 38.1 bits (87), Expect = 0.057
 Identities = 22/54 (40%), Positives = 30/54 (55%), Gaps = 4/54 (7%)

Query: 310 ASALADFQGSGPEEMTFRGGDLIEILGAQVPSLPWCVGRHAASGRVGFVRSSLI 363
           A A  DF    P +++FR GD+IE+L  + P   W  GR  + GRVGF   S +
Sbjct: 163 AQAQFDFSAQDPSQLSFRRGDIIEVL--ERPDPHWWRGR--SCGRVGFFPRSYV 212


>gi|56550039 myeloid/lymphoid or mixed-lineage leukemia protein [Homo
            sapiens]
          Length = 3969

 Score = 37.7 bits (86), Expect = 0.074
 Identities = 26/81 (32%), Positives = 34/81 (41%), Gaps = 4/81 (4%)

Query: 394  EDARQLLRRMSGTDVCSVYSLDSVEEAETEQPQEKEIPPPCLSPEPQETLQKVKNVLEQC 453
            E+  ++L  M   D  S+      E+AE   P  K I P   +  PQE   K      +C
Sbjct: 1099 EEREKILSSMGNDDKSSIAGS---EDAEPLAPPIKPIKPVTRNKAPQEPPVKKGRRSRRC 1155

Query: 454  KTCPGCPQEPASWGLCAASSD 474
              CPGC Q P   G+C    D
Sbjct: 1156 GQCPGC-QVPEDCGVCTNCLD 1175


>gi|39930351 dynamin binding protein [Homo sapiens]
          Length = 1577

 Score = 37.7 bits (86), Expect = 0.074
 Identities = 23/74 (31%), Positives = 35/74 (47%), Gaps = 4/74 (5%)

Query: 303 PLMAVGLASALADFQGSGPEEMTFRGGDLIEILGAQVPSLPWCVGRHAASGRVGFVRSSL 362
           P  ++G A AL        EE+ FR GD+I I+G  VP   W  G     GR G      
Sbjct: 143 PEYSMGQARALMGLSAQLDEELDFREGDVITIIG--VPEPGWFEGE--LEGRRGIFPEGF 198

Query: 363 ISMQGPVSELESAI 376
           + + GP+  ++ ++
Sbjct: 199 VELLGPLRTVDESV 212


>gi|239758086 PREDICTED: similar to double homeobox, 4 [Homo
           sapiens]
          Length = 422

 Score = 36.6 bits (83), Expect = 0.17
 Identities = 33/112 (29%), Positives = 43/112 (38%), Gaps = 15/112 (13%)

Query: 217 PDHHVRVMTGPRDAGN-GPQALRQASGAPQGEAAPETDSSPPSPSVSSEEVAVAAAPEPL 275
           P HH+  +      G  G Q  R        +AAP    S P+P++     A  A PE  
Sbjct: 191 PPHHLPCVPAALPTGAFGSQGARAVPVLXPSQAAPAEGISQPAPALKHFAYAAPAPPEGA 250

Query: 276 IPFHQWALRIP---------QDPIDDAMGGPVMPGNPLMAVGLASALADFQG 318
           +  H  A R P         +DP  D + GP   G P    G A A+   QG
Sbjct: 251 LS-HPQATRWPPHPGKSWEDRDPQRDGLSGPCAVGQP----GPAQAVPHGQG 297


>gi|21493022 A kinase (PRKA) anchor protein 12 isoform 1 [Homo
            sapiens]
          Length = 1782

 Score = 36.6 bits (83), Expect = 0.17
 Identities = 49/223 (21%), Positives = 82/223 (36%), Gaps = 50/223 (22%)

Query: 241  SGAPQGEAAPETDSSPPSPS------------------------VSSEEVAVAAAPEPLI 276
            SG  + EA P     PP+PS                        VS E V++ +  E   
Sbjct: 1206 SGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSILSKTEGTQ 1265

Query: 277  PFHQWALRIPQD-PIDDAMGGPVMPGNPLMAVGLASALADFQGSGPEEMTFRGGDLIEIL 335
               Q+A    +D P  + + G +  G  +    +       +G G EE   +  D +E+ 
Sbjct: 1266 EADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVA--LKGEGTEEAECKKDDALELQ 1323

Query: 336  GAQVPSLPWCVGRHAASGRVGFVRSSLISMQGPVSELESAIFLNEEEKSFFSEGCFSEED 395
                         HA S      R  ++ ++   +E E    +NEE+    +    SEE 
Sbjct: 1324 S------------HAKSPPSPVEREMVVQVEREKTEAEPT-HVNEEKLEHETAVTVSEEV 1370

Query: 396  ARQLLRRMSGTDVCSVYSLDSVEEAETEQPQEKEIPPPCLSPE 438
            ++QLL+ ++   +     + S+E +          PPPCL  E
Sbjct: 1371 SKQLLQTVNVPIIDGAKEVSSLEGS----------PPPCLGQE 1403


>gi|21493024 A kinase (PRKA) anchor protein 12 isoform 2 [Homo
            sapiens]
          Length = 1684

 Score = 36.6 bits (83), Expect = 0.17
 Identities = 49/223 (21%), Positives = 82/223 (36%), Gaps = 50/223 (22%)

Query: 241  SGAPQGEAAPETDSSPPSPS------------------------VSSEEVAVAAAPEPLI 276
            SG  + EA P     PP+PS                        VS E V++ +  E   
Sbjct: 1108 SGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSILSKTEGTQ 1167

Query: 277  PFHQWALRIPQD-PIDDAMGGPVMPGNPLMAVGLASALADFQGSGPEEMTFRGGDLIEIL 335
               Q+A    +D P  + + G +  G  +    +       +G G EE   +  D +E+ 
Sbjct: 1168 EADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVA--LKGEGTEEAECKKDDALELQ 1225

Query: 336  GAQVPSLPWCVGRHAASGRVGFVRSSLISMQGPVSELESAIFLNEEEKSFFSEGCFSEED 395
                         HA S      R  ++ ++   +E E    +NEE+    +    SEE 
Sbjct: 1226 S------------HAKSPPSPVEREMVVQVEREKTEAEPT-HVNEEKLEHETAVTVSEEV 1272

Query: 396  ARQLLRRMSGTDVCSVYSLDSVEEAETEQPQEKEIPPPCLSPE 438
            ++QLL+ ++   +     + S+E +          PPPCL  E
Sbjct: 1273 SKQLLQTVNVPIIDGAKEVSSLEGS----------PPPCLGQE 1305


>gi|39930517 sterile alpha motif domain containing 1 [Homo sapiens]
          Length = 538

 Score = 36.2 bits (82), Expect = 0.22
 Identities = 32/102 (31%), Positives = 41/102 (40%), Gaps = 9/102 (8%)

Query: 227 PRDAGNGPQALRQA--SGAPQGEAAPETDSSP------PSPSVSSEEVAVAAAPEPLIPF 278
           P  A  GP+A R A  +  P   AAP   + P      P P+V++ E  +   P+P  P 
Sbjct: 162 PGPAQPGPRAQRAAPLAAPPPAPAAPPAVAPPAGPRRAPPPAVAAREPPLPPPPQPPAPP 221

Query: 279 HQWALRIPQDPIDDAMGGPVMPGNPLMAVGLASALADFQGSG 320
            Q     PQ P     GG V  G     V L   +    GSG
Sbjct: 222 QQQQPPPPQ-PQPPPEGGAVRAGGAARPVSLREVVRYLGGSG 262


>gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Homo
           sapiens]
          Length = 847

 Score = 35.4 bits (80), Expect = 0.37
 Identities = 28/90 (31%), Positives = 39/90 (43%), Gaps = 9/90 (10%)

Query: 295 GGPVMPGNPLMAVGLAS----ALADFQGSGPEEMTFRGGDLIEILGAQVP---SLPWCVG 347
           GG   P     A G A+    AL D++ SG +E+  R GD +E+L           W  G
Sbjct: 27  GGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAG 86

Query: 348 RHAASGRVGFVRSSLISMQGPVSELESAIF 377
           +    G+VG   S+ +S  G     E A F
Sbjct: 87  Q--VGGQVGIFPSNYVSRGGGPPPCEVASF 114


>gi|120432042 vav 3 guanine nucleotide exchange factor isoform 2
           [Homo sapiens]
          Length = 287

 Score = 35.0 bits (79), Expect = 0.48
 Identities = 30/100 (30%), Positives = 45/100 (45%), Gaps = 16/100 (16%)

Query: 274 PLIPF--HQWALRIPQDPIDDAMGGP--VMPGNPLMAVGLASALADFQGSGPEEM----- 324
           P+  F   Q  L++P+   +     P  V PG P M V     + ++ G+ P  +     
Sbjct: 2   PIFTFLSEQGTLKLPEKRTNGLRRTPKQVDPGLPKMQV-----IRNYSGTPPPALHEGPP 56

Query: 325 -TFRGGDLIEILGAQVPSLPWCVGRHAASGRVGFVRSSLI 363
              + GD +E+L     SL W  GR+ ASG VGF  S  +
Sbjct: 57  LQLQAGDTVELLKGDAHSLFW-QGRNLASGEVGFFPSDAV 95


>gi|24497620 signal recognition particle 68kDa [Homo sapiens]
          Length = 627

 Score = 35.0 bits (79), Expect = 0.48
 Identities = 26/89 (29%), Positives = 44/89 (49%), Gaps = 13/89 (14%)

Query: 646 ELLQL-------ALRRAVGGQSLQAEARACFLLARHHVHLKQPEEALPFLERLLLLHRDS 698
           ELLQL       A ++ +G ++L  +A  CF +A+ +V +K+  EAL   +R+L    + 
Sbjct: 437 ELLQLPGLEEDKAFQKEIGLKTLVFKAYRCFFIAQSYVLVKKWSEALVLYDRVLKYANEV 496

Query: 699 GAPEAAW------LSDCYLLLADIYSRKC 721
            +   A+      L D   L+  + S KC
Sbjct: 497 NSDAGAFKNSLKDLPDVQELITQVRSEKC 525


>gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1
           [Homo sapiens]
          Length = 847

 Score = 34.7 bits (78), Expect = 0.63
 Identities = 28/92 (30%), Positives = 42/92 (45%), Gaps = 14/92 (15%)

Query: 280 QWALRIPQDPIDDAMGGP--VMPGNPLMAVGLASALADFQGSGPEEM------TFRGGDL 331
           Q  L++P+   +     P  V PG P M V     + ++ G+ P  +        + GD 
Sbjct: 570 QGTLKLPEKRTNGLRRTPKQVDPGLPKMQV-----IRNYSGTPPPALHEGPPLQLQAGDT 624

Query: 332 IEILGAQVPSLPWCVGRHAASGRVGFVRSSLI 363
           +E+L     SL W  GR+ ASG VGF  S  +
Sbjct: 625 VELLKGDAHSLFW-QGRNLASGEVGFFPSDAV 655


>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
           sapiens]
          Length = 5537

 Score = 34.3 bits (77), Expect = 0.82
 Identities = 24/72 (33%), Positives = 34/72 (47%), Gaps = 7/72 (9%)

Query: 418 EEAETEQPQEKEIPP----PCLSPEPQETLQKVKNVLEQCKTCPGCPQEPASWGLCAASS 473
           E   + QP+E  + P    PCLSP P+E+   +   LE+    P   + P   G C A  
Sbjct: 821 EPCLSPQPEESHLSPQSEEPCLSPRPEES--HLSPELEKPPLSPRPEKPPEEPGQCPAPE 878

Query: 474 DVSL-QDPEEPS 484
           ++ L   P EPS
Sbjct: 879 ELPLFPPPGEPS 890


>gi|21735550 mitogen-activated protein kinase kinase kinase 10 [Homo
           sapiens]
          Length = 954

 Score = 34.3 bits (77), Expect = 0.82
 Identities = 20/63 (31%), Positives = 34/63 (53%), Gaps = 4/63 (6%)

Query: 311 SALADFQGSGPEEMTFRGGDLIEILG---AQVPSLPWCVGRHAASGRVGFVRSSLISMQG 367
           +A+ D++ +G EE+T R GD +++L    A      W  G+   SGRVG   S+ ++   
Sbjct: 22  TAVFDYEAAGDEELTLRRGDRVQVLSQDCAVSGDEGWWTGQ-LPSGRVGVFPSNYVAPGA 80

Query: 368 PVS 370
           P +
Sbjct: 81  PAA 83


>gi|116089276 tetratricopeptide repeat domain 23-like [Homo sapiens]
          Length = 361

 Score = 33.9 bits (76), Expect = 1.1
 Identities = 27/105 (25%), Positives = 51/105 (48%), Gaps = 2/105 (1%)

Query: 562 LCFLLGRLCSRRLKLSQARVYFEEALGALEGSFGDLFL-VVAVYANLASIYRKQKNREKC 620
           L   LGR      +L+ A  YFE+A+G +  + GD    ++++Y   A I + ++N  + 
Sbjct: 215 LTLALGRASLAIHRLNLALAYFEKAIGDVIAAKGDRTSDLISLYEEAAQIEQLRRNHNQA 274

Query: 621 AQVVPKAMALLLGTPDHICSTEAEGELLQLALRRAVGGQSLQAEA 665
            Q + +A ++ +     +    AE   L LA   A+ G++   +A
Sbjct: 275 IQYLQQAHSVCVSLFTEVSPKTAEMSAL-LAKAYAMSGEAQHRDA 318


>gi|33286446 opioid growth factor receptor [Homo sapiens]
          Length = 677

 Score = 33.5 bits (75), Expect = 1.4
 Identities = 25/72 (34%), Positives = 30/72 (41%), Gaps = 9/72 (12%)

Query: 2   ENLPAVTTEEPTPMGRGPVGPSGGGSTRDQVRTVVMRPSVSWEKAGPEEAKAPVRGDEAP 61
           E  P   +E P P    P GP+G         T   RP+     AG E A++P    E P
Sbjct: 512 EGTPGSPSETPGP---SPAGPAGDEPAESPSETPGPRPA---GPAGDEPAESP---SETP 562

Query: 62  PARVAGPAAGTP 73
             R AGPA   P
Sbjct: 563 GPRPAGPAGDEP 574



 Score = 30.8 bits (68), Expect = 9.1
 Identities = 25/69 (36%), Positives = 30/69 (43%), Gaps = 11/69 (15%)

Query: 10  EEPTPMGRGPVGPSGGGSTRDQV-----RTVVMRPSVSWEKAGPEEAKAPVRGDEAPPAR 64
           +EP        GPS  G TRD+       T   RP+     AG E A++P    E P  R
Sbjct: 572 DEPAESPSETPGPSPAGPTRDEPAESPSETPGPRPA---GPAGDEPAESP---SETPGPR 625

Query: 65  VAGPAAGTP 73
            AGPA   P
Sbjct: 626 PAGPAGDEP 634


>gi|194097382 ADP-ribosyltransferase 3 isoform c [Homo sapiens]
          Length = 367

 Score = 33.5 bits (75), Expect = 1.4
 Identities = 50/184 (27%), Positives = 70/184 (38%), Gaps = 26/184 (14%)

Query: 1114 EAAGDIFFDGAWEREKAVSFYRDRALPLAVTTGNRKAELRLCNKLVALLATLEEPQEGLE 1173
            E A     D  WE  KA    R   + L +   +        N  +AL+A + E QE   
Sbjct: 59   EKASHQQLDTVWENAKAKWAARKTQIFLPMNFKD--------NHGIALMAYISEAQEQTP 110

Query: 1174 FAHMALALSITLGDRLNERVAYHRLAALQHRLGHGELAEHFYL-KALSLCNSPLEFDEET 1232
            F H+  + ++ +  +  E   Y          G    A HFYL +AL L   P E   +T
Sbjct: 111  FYHL-FSEAVKMAGQSREDYIY----------GFQFKAFHFYLTRALQLLRKPCEASSKT 159

Query: 1233 LYYVKVYLVLGDIIFYDLKDPFDAAGYYQLALAAAVDLGNKK-AQLKIYTRLATIYHNFL 1291
            + Y           F  L       G++ LA +A     N +   L IYT L     NF 
Sbjct: 160  VVYRTSQGT--SFTFGGLNQA--RFGHFTLAYSAKPQAANDQLTVLSIYTCLGVDIENF- 214

Query: 1292 LDRE 1295
            LD+E
Sbjct: 215  LDKE 218


>gi|194097380 ADP-ribosyltransferase 3 isoform a [Homo sapiens]
          Length = 389

 Score = 33.5 bits (75), Expect = 1.4
 Identities = 50/184 (27%), Positives = 70/184 (38%), Gaps = 26/184 (14%)

Query: 1114 EAAGDIFFDGAWEREKAVSFYRDRALPLAVTTGNRKAELRLCNKLVALLATLEEPQEGLE 1173
            E A     D  WE  KA    R   + L +   +        N  +AL+A + E QE   
Sbjct: 59   EKASHQQLDTVWENAKAKWAARKTQIFLPMNFKD--------NHGIALMAYISEAQEQTP 110

Query: 1174 FAHMALALSITLGDRLNERVAYHRLAALQHRLGHGELAEHFYL-KALSLCNSPLEFDEET 1232
            F H+  + ++ +  +  E   Y          G    A HFYL +AL L   P E   +T
Sbjct: 111  FYHL-FSEAVKMAGQSREDYIY----------GFQFKAFHFYLTRALQLLRKPCEASSKT 159

Query: 1233 LYYVKVYLVLGDIIFYDLKDPFDAAGYYQLALAAAVDLGNKK-AQLKIYTRLATIYHNFL 1291
            + Y           F  L       G++ LA +A     N +   L IYT L     NF 
Sbjct: 160  VVYRTSQGT--SFTFGGLNQA--RFGHFTLAYSAKPQAANDQLTVLSIYTCLGVDIENF- 214

Query: 1292 LDRE 1295
            LD+E
Sbjct: 215  LDKE 218


>gi|21361167 ADP-ribosyltransferase 3 isoform b [Homo sapiens]
          Length = 378

 Score = 33.5 bits (75), Expect = 1.4
 Identities = 50/184 (27%), Positives = 70/184 (38%), Gaps = 26/184 (14%)

Query: 1114 EAAGDIFFDGAWEREKAVSFYRDRALPLAVTTGNRKAELRLCNKLVALLATLEEPQEGLE 1173
            E A     D  WE  KA    R   + L +   +        N  +AL+A + E QE   
Sbjct: 59   EKASHQQLDTVWENAKAKWAARKTQIFLPMNFKD--------NHGIALMAYISEAQEQTP 110

Query: 1174 FAHMALALSITLGDRLNERVAYHRLAALQHRLGHGELAEHFYL-KALSLCNSPLEFDEET 1232
            F H+  + ++ +  +  E   Y          G    A HFYL +AL L   P E   +T
Sbjct: 111  FYHL-FSEAVKMAGQSREDYIY----------GFQFKAFHFYLTRALQLLRKPCEASSKT 159

Query: 1233 LYYVKVYLVLGDIIFYDLKDPFDAAGYYQLALAAAVDLGNKK-AQLKIYTRLATIYHNFL 1291
            + Y           F  L       G++ LA +A     N +   L IYT L     NF 
Sbjct: 160  VVYRTSQGT--SFTFGGLNQA--RFGHFTLAYSAKPQAANDQLTVLSIYTCLGVDIENF- 214

Query: 1292 LDRE 1295
            LD+E
Sbjct: 215  LDKE 218


>gi|134031945 SCO-spondin [Homo sapiens]
          Length = 5147

 Score = 33.5 bits (75), Expect = 1.4
 Identities = 20/61 (32%), Positives = 24/61 (39%), Gaps = 8/61 (13%)

Query: 432  PPCLSPEPQETLQKVKNVLEQCKTCPGCPQEPASWGLCAASSDVSLQDPEEPSFCLEAED 491
            PPCL P+ Q   Q    +LE C   P        WG C+ S    L        CL A+ 
Sbjct: 4290 PPCLGPDTQTRQQPCPGLLEACSWGP--------WGPCSRSCGPGLASRSGSCPCLMAKA 4341

Query: 492  D 492
            D
Sbjct: 4342 D 4342


>gi|196259776 peroxisomal biogenesis factor 5 isoform d [Homo
           sapiens]
          Length = 639

 Score = 33.1 bits (74), Expect = 1.8
 Identities = 31/114 (27%), Positives = 50/114 (43%), Gaps = 12/114 (10%)

Query: 831 LAWLHVLHGQSPVALDILQSVRDAVVASEDQEGVIANMVAVALKRTGRTRQAAESYYRAL 890
           L  L  L G+   A+D       A ++    + ++ N +   L    ++ +A  +Y RAL
Sbjct: 494 LGVLFNLSGEYDKAVDCFT----AALSVRPNDYLLWNKLGATLANGNQSEEAVAAYRRAL 549

Query: 891 RVARDLGQQRNQAVGLANFGALCLHAGASRLAQHYLLEAVRL--FSRLPLGECG 942
            +     + R       N G  C++ GA R A  + LEA+ +   SR P GE G
Sbjct: 550 ELQPGYIRSRY------NLGISCINLGAHREAVEHFLEALNMQRKSRGPRGEGG 597


>gi|196259774 peroxisomal biogenesis factor 5 isoform d [Homo
           sapiens]
          Length = 639

 Score = 33.1 bits (74), Expect = 1.8
 Identities = 31/114 (27%), Positives = 50/114 (43%), Gaps = 12/114 (10%)

Query: 831 LAWLHVLHGQSPVALDILQSVRDAVVASEDQEGVIANMVAVALKRTGRTRQAAESYYRAL 890
           L  L  L G+   A+D       A ++    + ++ N +   L    ++ +A  +Y RAL
Sbjct: 494 LGVLFNLSGEYDKAVDCFT----AALSVRPNDYLLWNKLGATLANGNQSEEAVAAYRRAL 549

Query: 891 RVARDLGQQRNQAVGLANFGALCLHAGASRLAQHYLLEAVRL--FSRLPLGECG 942
            +     + R       N G  C++ GA R A  + LEA+ +   SR P GE G
Sbjct: 550 ELQPGYIRSRY------NLGISCINLGAHREAVEHFLEALNMQRKSRGPRGEGG 597


>gi|196259772 peroxisomal biogenesis factor 5 isoform c [Homo
           sapiens]
          Length = 602

 Score = 33.1 bits (74), Expect = 1.8
 Identities = 31/114 (27%), Positives = 50/114 (43%), Gaps = 12/114 (10%)

Query: 831 LAWLHVLHGQSPVALDILQSVRDAVVASEDQEGVIANMVAVALKRTGRTRQAAESYYRAL 890
           L  L  L G+   A+D       A ++    + ++ N +   L    ++ +A  +Y RAL
Sbjct: 457 LGVLFNLSGEYDKAVDCFT----AALSVRPNDYLLWNKLGATLANGNQSEEAVAAYRRAL 512

Query: 891 RVARDLGQQRNQAVGLANFGALCLHAGASRLAQHYLLEAVRL--FSRLPLGECG 942
            +     + R       N G  C++ GA R A  + LEA+ +   SR P GE G
Sbjct: 513 ELQPGYIRSRY------NLGISCINLGAHREAVEHFLEALNMQRKSRGPRGEGG 560


>gi|196259770 peroxisomal biogenesis factor 5 isoform a [Homo
           sapiens]
          Length = 654

 Score = 33.1 bits (74), Expect = 1.8
 Identities = 31/114 (27%), Positives = 50/114 (43%), Gaps = 12/114 (10%)

Query: 831 LAWLHVLHGQSPVALDILQSVRDAVVASEDQEGVIANMVAVALKRTGRTRQAAESYYRAL 890
           L  L  L G+   A+D       A ++    + ++ N +   L    ++ +A  +Y RAL
Sbjct: 509 LGVLFNLSGEYDKAVDCFT----AALSVRPNDYLLWNKLGATLANGNQSEEAVAAYRRAL 564

Query: 891 RVARDLGQQRNQAVGLANFGALCLHAGASRLAQHYLLEAVRL--FSRLPLGECG 942
            +     + R       N G  C++ GA R A  + LEA+ +   SR P GE G
Sbjct: 565 ELQPGYIRSRY------NLGISCINLGAHREAVEHFLEALNMQRKSRGPRGEGG 612


>gi|21361204 peroxisomal biogenesis factor 5 isoform b [Homo
           sapiens]
          Length = 631

 Score = 33.1 bits (74), Expect = 1.8
 Identities = 31/114 (27%), Positives = 50/114 (43%), Gaps = 12/114 (10%)

Query: 831 LAWLHVLHGQSPVALDILQSVRDAVVASEDQEGVIANMVAVALKRTGRTRQAAESYYRAL 890
           L  L  L G+   A+D       A ++    + ++ N +   L    ++ +A  +Y RAL
Sbjct: 486 LGVLFNLSGEYDKAVDCFT----AALSVRPNDYLLWNKLGATLANGNQSEEAVAAYRRAL 541

Query: 891 RVARDLGQQRNQAVGLANFGALCLHAGASRLAQHYLLEAVRL--FSRLPLGECG 942
            +     + R       N G  C++ GA R A  + LEA+ +   SR P GE G
Sbjct: 542 ELQPGYIRSRY------NLGISCINLGAHREAVEHFLEALNMQRKSRGPRGEGG 589


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.135    0.404 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 53,417,195
Number of Sequences: 37866
Number of extensions: 2612820
Number of successful extensions: 11354
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 20
Number of HSP's successfully gapped in prelim test: 110
Number of HSP's that attempted gapping in prelim test: 11043
Number of HSP's gapped (non-prelim): 399
length of query: 1336
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1222
effective length of database: 13,930,794
effective search space: 17023430268
effective search space used: 17023430268
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.