Guide to the Human Genome
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Search of human proteins with 109659847

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|109659847 filamin A interacting protein 1-like isoform 3
[Homo sapiens]
         (1133 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|109659847 filamin A interacting protein 1-like isoform 3 [Hom...  2211   0.0  
gi|109659845 filamin A interacting protein 1-like isoform 1 [Hom...  2201   0.0  
gi|109659849 filamin A interacting protein 1-like isoform 2 [Hom...  1739   0.0  
gi|31542634 filamin A interacting protein 1 [Homo sapiens]            934   0.0  
gi|216548091 leucine zipper protein 1 [Homo sapiens]                  259   1e-68
gi|216548085 leucine zipper protein 1 [Homo sapiens]                  259   1e-68
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...   146   1e-34
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...   146   1e-34
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...   146   1e-34
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...   146   1e-34
gi|24308179 CTTNBP2 N-terminal like [Homo sapiens]                    145   2e-34
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]   134   6e-31
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]    132   2e-30
gi|71061468 centromere protein E [Homo sapiens]                       132   2e-30
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]    127   5e-29
gi|45439327 periplakin [Homo sapiens]                                 124   4e-28
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]            124   5e-28
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa...   122   2e-27
gi|58530840 desmoplakin isoform I [Homo sapiens]                      120   6e-27
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s...   120   7e-27
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa...   119   2e-26
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo...   119   2e-26
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo...   119   2e-26
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ...   118   4e-26
gi|28416946 myosin 18A isoform a [Homo sapiens]                       117   6e-26
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo...   116   1e-25
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [...   116   1e-25
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]                  116   1e-25
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s...   115   2e-25
gi|4506751 restin isoform a [Homo sapiens]                            115   3e-25

>gi|109659847 filamin A interacting protein 1-like isoform 3 [Homo
            sapiens]
          Length = 1133

 Score = 2211 bits (5729), Expect = 0.0
 Identities = 1133/1133 (100%), Positives = 1133/1133 (100%)

Query: 1    MRSRGSDTEGSAQKKFPRHTKGHSFQGPKNMKHRQQDKDSPSESDVILPCPKAEKPHSGN 60
            MRSRGSDTEGSAQKKFPRHTKGHSFQGPKNMKHRQQDKDSPSESDVILPCPKAEKPHSGN
Sbjct: 1    MRSRGSDTEGSAQKKFPRHTKGHSFQGPKNMKHRQQDKDSPSESDVILPCPKAEKPHSGN 60

Query: 61   GHQAEDLSRDDLLFLLSILEGELQARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQ 120
            GHQAEDLSRDDLLFLLSILEGELQARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQ
Sbjct: 61   GHQAEDLSRDDLLFLLSILEGELQARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQ 120

Query: 121  RDAFQAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKR 180
            RDAFQAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKR
Sbjct: 121  RDAFQAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKR 180

Query: 181  KHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFAL 240
            KHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFAL
Sbjct: 181  KHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFAL 240

Query: 241  MVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTT 300
            MVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTT
Sbjct: 241  MVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTT 300

Query: 301  KFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISK 360
            KFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISK
Sbjct: 301  KFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISK 360

Query: 361  GEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKL 420
            GEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKL
Sbjct: 361  GEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKL 420

Query: 421  SKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLE 480
            SKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLE
Sbjct: 421  SKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLE 480

Query: 481  KTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLI 540
            KTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLI
Sbjct: 481  KTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLI 540

Query: 541  EETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEK 600
            EETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEK
Sbjct: 541  EETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEK 600

Query: 601  DFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLE 660
            DFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLE
Sbjct: 601  DFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLE 660

Query: 661  RRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVD 720
            RRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVD
Sbjct: 661  RRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVD 720

Query: 721  ALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKS 780
            ALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKS
Sbjct: 721  ALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKS 780

Query: 781  LRPSLNGRRISDPQVFSKEVQTEAVDNEPPDYKSLIPLERAVINGQLYEESENQDEDPND 840
            LRPSLNGRRISDPQVFSKEVQTEAVDNEPPDYKSLIPLERAVINGQLYEESENQDEDPND
Sbjct: 781  LRPSLNGRRISDPQVFSKEVQTEAVDNEPPDYKSLIPLERAVINGQLYEESENQDEDPND 840

Query: 841  EGSVLSFKCSQSTPCPVNRKLWIPWMKSKEGHLQNGKMQTKPNANFVQPGDLVLSHTPGQ 900
            EGSVLSFKCSQSTPCPVNRKLWIPWMKSKEGHLQNGKMQTKPNANFVQPGDLVLSHTPGQ
Sbjct: 841  EGSVLSFKCSQSTPCPVNRKLWIPWMKSKEGHLQNGKMQTKPNANFVQPGDLVLSHTPGQ 900

Query: 901  PLHIKVTPDHVQNTATLEITSPTTESPHSYTSTAVIPNCGTPKQRITILQNASITPVKSK 960
            PLHIKVTPDHVQNTATLEITSPTTESPHSYTSTAVIPNCGTPKQRITILQNASITPVKSK
Sbjct: 901  PLHIKVTPDHVQNTATLEITSPTTESPHSYTSTAVIPNCGTPKQRITILQNASITPVKSK 960

Query: 961  TSTEDLMNLEQGMSPITMATFARAQTPESCGSLTPERTMSPIQVLAVTGSASSPEQGRSP 1020
            TSTEDLMNLEQGMSPITMATFARAQTPESCGSLTPERTMSPIQVLAVTGSASSPEQGRSP
Sbjct: 961  TSTEDLMNLEQGMSPITMATFARAQTPESCGSLTPERTMSPIQVLAVTGSASSPEQGRSP 1020

Query: 1021 EPTEISAKHAIFRVSPDRQSSWQFQRSNSNSSSVITTEDNKIHIHLGSPYMQAVASPVRP 1080
            EPTEISAKHAIFRVSPDRQSSWQFQRSNSNSSSVITTEDNKIHIHLGSPYMQAVASPVRP
Sbjct: 1021 EPTEISAKHAIFRVSPDRQSSWQFQRSNSNSSSVITTEDNKIHIHLGSPYMQAVASPVRP 1080

Query: 1081 ASPSAPLQDNRTQGLINGALNKTTNKVTSSITITPTATPLPRQSQITVSNIYN 1133
            ASPSAPLQDNRTQGLINGALNKTTNKVTSSITITPTATPLPRQSQITVSNIYN
Sbjct: 1081 ASPSAPLQDNRTQGLINGALNKTTNKVTSSITITPTATPLPRQSQITVSNIYN 1133


>gi|109659845 filamin A interacting protein 1-like isoform 1 [Homo
            sapiens]
          Length = 1135

 Score = 2201 bits (5702), Expect = 0.0
 Identities = 1128/1128 (100%), Positives = 1128/1128 (100%)

Query: 1    MRSRGSDTEGSAQKKFPRHTKGHSFQGPKNMKHRQQDKDSPSESDVILPCPKAEKPHSGN 60
            MRSRGSDTEGSAQKKFPRHTKGHSFQGPKNMKHRQQDKDSPSESDVILPCPKAEKPHSGN
Sbjct: 1    MRSRGSDTEGSAQKKFPRHTKGHSFQGPKNMKHRQQDKDSPSESDVILPCPKAEKPHSGN 60

Query: 61   GHQAEDLSRDDLLFLLSILEGELQARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQ 120
            GHQAEDLSRDDLLFLLSILEGELQARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQ
Sbjct: 61   GHQAEDLSRDDLLFLLSILEGELQARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQ 120

Query: 121  RDAFQAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKR 180
            RDAFQAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKR
Sbjct: 121  RDAFQAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKR 180

Query: 181  KHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFAL 240
            KHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFAL
Sbjct: 181  KHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFAL 240

Query: 241  MVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTT 300
            MVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTT
Sbjct: 241  MVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTT 300

Query: 301  KFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISK 360
            KFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISK
Sbjct: 301  KFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISK 360

Query: 361  GEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKL 420
            GEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKL
Sbjct: 361  GEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKL 420

Query: 421  SKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLE 480
            SKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLE
Sbjct: 421  SKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLE 480

Query: 481  KTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLI 540
            KTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLI
Sbjct: 481  KTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLI 540

Query: 541  EETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEK 600
            EETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEK
Sbjct: 541  EETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEK 600

Query: 601  DFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLE 660
            DFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLE
Sbjct: 601  DFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLE 660

Query: 661  RRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVD 720
            RRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVD
Sbjct: 661  RRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVD 720

Query: 721  ALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKS 780
            ALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKS
Sbjct: 721  ALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKS 780

Query: 781  LRPSLNGRRISDPQVFSKEVQTEAVDNEPPDYKSLIPLERAVINGQLYEESENQDEDPND 840
            LRPSLNGRRISDPQVFSKEVQTEAVDNEPPDYKSLIPLERAVINGQLYEESENQDEDPND
Sbjct: 781  LRPSLNGRRISDPQVFSKEVQTEAVDNEPPDYKSLIPLERAVINGQLYEESENQDEDPND 840

Query: 841  EGSVLSFKCSQSTPCPVNRKLWIPWMKSKEGHLQNGKMQTKPNANFVQPGDLVLSHTPGQ 900
            EGSVLSFKCSQSTPCPVNRKLWIPWMKSKEGHLQNGKMQTKPNANFVQPGDLVLSHTPGQ
Sbjct: 841  EGSVLSFKCSQSTPCPVNRKLWIPWMKSKEGHLQNGKMQTKPNANFVQPGDLVLSHTPGQ 900

Query: 901  PLHIKVTPDHVQNTATLEITSPTTESPHSYTSTAVIPNCGTPKQRITILQNASITPVKSK 960
            PLHIKVTPDHVQNTATLEITSPTTESPHSYTSTAVIPNCGTPKQRITILQNASITPVKSK
Sbjct: 901  PLHIKVTPDHVQNTATLEITSPTTESPHSYTSTAVIPNCGTPKQRITILQNASITPVKSK 960

Query: 961  TSTEDLMNLEQGMSPITMATFARAQTPESCGSLTPERTMSPIQVLAVTGSASSPEQGRSP 1020
            TSTEDLMNLEQGMSPITMATFARAQTPESCGSLTPERTMSPIQVLAVTGSASSPEQGRSP
Sbjct: 961  TSTEDLMNLEQGMSPITMATFARAQTPESCGSLTPERTMSPIQVLAVTGSASSPEQGRSP 1020

Query: 1021 EPTEISAKHAIFRVSPDRQSSWQFQRSNSNSSSVITTEDNKIHIHLGSPYMQAVASPVRP 1080
            EPTEISAKHAIFRVSPDRQSSWQFQRSNSNSSSVITTEDNKIHIHLGSPYMQAVASPVRP
Sbjct: 1021 EPTEISAKHAIFRVSPDRQSSWQFQRSNSNSSSVITTEDNKIHIHLGSPYMQAVASPVRP 1080

Query: 1081 ASPSAPLQDNRTQGLINGALNKTTNKVTSSITITPTATPLPRQSQITV 1128
            ASPSAPLQDNRTQGLINGALNKTTNKVTSSITITPTATPLPRQSQITV
Sbjct: 1081 ASPSAPLQDNRTQGLINGALNKTTNKVTSSITITPTATPLPRQSQITV 1128


>gi|109659849 filamin A interacting protein 1-like isoform 2 [Homo
            sapiens]
          Length = 893

 Score = 1739 bits (4504), Expect = 0.0
 Identities = 893/893 (100%), Positives = 893/893 (100%)

Query: 241  MVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTT 300
            MVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTT
Sbjct: 1    MVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTT 60

Query: 301  KFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISK 360
            KFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISK
Sbjct: 61   KFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISK 120

Query: 361  GEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKL 420
            GEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKL
Sbjct: 121  GEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKL 180

Query: 421  SKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLE 480
            SKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLE
Sbjct: 181  SKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLE 240

Query: 481  KTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLI 540
            KTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLI
Sbjct: 241  KTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLI 300

Query: 541  EETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEK 600
            EETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEK
Sbjct: 301  EETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEK 360

Query: 601  DFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLE 660
            DFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLE
Sbjct: 361  DFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLE 420

Query: 661  RRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVD 720
            RRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVD
Sbjct: 421  RRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVD 480

Query: 721  ALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKS 780
            ALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKS
Sbjct: 481  ALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKS 540

Query: 781  LRPSLNGRRISDPQVFSKEVQTEAVDNEPPDYKSLIPLERAVINGQLYEESENQDEDPND 840
            LRPSLNGRRISDPQVFSKEVQTEAVDNEPPDYKSLIPLERAVINGQLYEESENQDEDPND
Sbjct: 541  LRPSLNGRRISDPQVFSKEVQTEAVDNEPPDYKSLIPLERAVINGQLYEESENQDEDPND 600

Query: 841  EGSVLSFKCSQSTPCPVNRKLWIPWMKSKEGHLQNGKMQTKPNANFVQPGDLVLSHTPGQ 900
            EGSVLSFKCSQSTPCPVNRKLWIPWMKSKEGHLQNGKMQTKPNANFVQPGDLVLSHTPGQ
Sbjct: 601  EGSVLSFKCSQSTPCPVNRKLWIPWMKSKEGHLQNGKMQTKPNANFVQPGDLVLSHTPGQ 660

Query: 901  PLHIKVTPDHVQNTATLEITSPTTESPHSYTSTAVIPNCGTPKQRITILQNASITPVKSK 960
            PLHIKVTPDHVQNTATLEITSPTTESPHSYTSTAVIPNCGTPKQRITILQNASITPVKSK
Sbjct: 661  PLHIKVTPDHVQNTATLEITSPTTESPHSYTSTAVIPNCGTPKQRITILQNASITPVKSK 720

Query: 961  TSTEDLMNLEQGMSPITMATFARAQTPESCGSLTPERTMSPIQVLAVTGSASSPEQGRSP 1020
            TSTEDLMNLEQGMSPITMATFARAQTPESCGSLTPERTMSPIQVLAVTGSASSPEQGRSP
Sbjct: 721  TSTEDLMNLEQGMSPITMATFARAQTPESCGSLTPERTMSPIQVLAVTGSASSPEQGRSP 780

Query: 1021 EPTEISAKHAIFRVSPDRQSSWQFQRSNSNSSSVITTEDNKIHIHLGSPYMQAVASPVRP 1080
            EPTEISAKHAIFRVSPDRQSSWQFQRSNSNSSSVITTEDNKIHIHLGSPYMQAVASPVRP
Sbjct: 781  EPTEISAKHAIFRVSPDRQSSWQFQRSNSNSSSVITTEDNKIHIHLGSPYMQAVASPVRP 840

Query: 1081 ASPSAPLQDNRTQGLINGALNKTTNKVTSSITITPTATPLPRQSQITVSNIYN 1133
            ASPSAPLQDNRTQGLINGALNKTTNKVTSSITITPTATPLPRQSQITVSNIYN
Sbjct: 841  ASPSAPLQDNRTQGLINGALNKTTNKVTSSITITPTATPLPRQSQITVSNIYN 893



 Score =  103 bits (258), Expect = 7e-22
 Identities = 103/427 (24%), Positives = 197/427 (46%), Gaps = 24/427 (5%)

Query: 65  EDLSRDDLLFLLSILEGELQARDEVIGILKAEKMDLA-----LLEAQYGFVTPKKVLEAL 119
           ED     L   L+ L  ++   +E    L+  + +L      + + +YG       +E L
Sbjct: 76  EDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEEL 135

Query: 120 QRDAFQAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILE-LEEE 178
           ++     +    +    E+   +L+K +E+  E+ +    +L V + S+R   LE LE+ 
Sbjct: 136 RKRVLDMEGKDEELIKMEEQCRDLNKRLER--ETLQSKDFKLEVEKLSKRIMALEKLEDA 193

Query: 179 KRKHKEY-------MEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEE 231
             K K+        +EK       L QE E LK      IK  E  E   EK   TLKE+
Sbjct: 194 FNKSKQECYSLKCNLEKERMTTKQLSQELESLKV----RIKELEAIESRLEKTEFTLKED 249

Query: 232 LTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRL 291
           LTKLK+  +M VDE++ ++ +L     K+Q  ++  +    K+     ++ EE ++A + 
Sbjct: 250 LTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKS 309

Query: 292 EKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEEL 351
           + +++ +     +++D +  KL  E+ +   L  ++  L  ++  LE   +   K +   
Sbjct: 310 KTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQ 369

Query: 352 QDIKEKISKGEYGN--AGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQ 409
              K   +  +  N    +  EVE L+ ++ DM+  +++L+K E++   L +R   E  +
Sbjct: 370 DSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDK 429

Query: 410 SKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRI 469
           ++    E+E + K  +A  KL +    S ++   L   L++E   +  LS+E+++LK +I
Sbjct: 430 AQFLSKELEHV-KMELAKYKLAEKTETSHEQW--LFKRLQEEEAKSGHLSREVDALKEKI 486

Query: 470 KELEAIE 476
            E  A E
Sbjct: 487 HEYMATE 493


>gi|31542634 filamin A interacting protein 1 [Homo sapiens]
          Length = 1213

 Score =  934 bits (2413), Expect = 0.0
 Identities = 518/1078 (48%), Positives = 727/1078 (67%), Gaps = 26/1078 (2%)

Query: 66   DLSRDDLLFLLSILEGELQARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQRDAFQ 125
            +LS++DL+ LLSI+EGELQAR++VI +LK EK    +LEA YG   P+KVL  L RDA  
Sbjct: 74   ELSKEDLIQLLSIMEGELQAREDVIHMLKTEKTKPEVLEAHYGSAEPEKVLRVLHRDAIL 133

Query: 126  AKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEY 185
            A+     ED+YEKP++ELD++ EK KE+YRR+L QLL+AEK  R+T+ ELE EK KH +Y
Sbjct: 134  AQEKSIGEDVYEKPISELDRLEEKQKETYRRMLEQLLLAEKCHRRTVYELENEKHKHTDY 193

Query: 186  MEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDE 245
            M KSD+F  LLEQE ERLKKL++QE   Q  KE+E  KR+  L++EL KLKSFALM+VDE
Sbjct: 194  MNKSDDFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDE 253

Query: 246  QQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQD 305
            +Q    QL LQ QK+Q+LT   +E   KL    ++ +E+ QK  +LE + + + ++F Q+
Sbjct: 254  RQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRFSQE 313

Query: 306  QDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGN 365
             + + AKL N++S NRQL+ KL  L+++I+ELEETN++L+KAEEELQ++++KI+KGE GN
Sbjct: 314  HEEMNAKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIAKGECGN 373

Query: 366  AGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIM 425
            + +MAEVE LRKRVL+MEGKDEE+ K E QCR+L K+L+ E   SK+ +LEVEKL KR+ 
Sbjct: 374  SSLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMS 433

Query: 426  ALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFT 485
             LEKLE+AF+KSK EC  L  NLEKE+  TK L  ELE +K R+KELE  ESRLEK E +
Sbjct: 434  ELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKAELS 493

Query: 486  LKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKR 545
            LK+DLTKLK+ TVM VDERK M EK+K+ E K+   +   +VEQ KV  VTEKLIEE+K+
Sbjct: 494  LKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKK 553

Query: 546  ALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKN 605
             LK K+++EEK+Y++T+ERD+L  KLK+EEEK ++L   V++LK RL  +E +E++  + 
Sbjct: 554  LLKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRG 613

Query: 606  KLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYAN 665
            +    S K +     E+NKIKEL+ E+ERLK +L+ ++ +E DLMKTEDEY+ LE+++  
Sbjct: 614  R----SRKGSELTCPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRT 669

Query: 666  ERDKAQFLSKELEHVKMELAKYKLAEKTE-TSHEQWLFKRLQEEEAKSGHLSREVDALKE 724
            E+DKA FLS++LE +K ++AK K  EK E  S E  L  R + EEAKS  L  EV ALKE
Sbjct: 670  EQDKANFLSQQLEEIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAEVQALKE 729

Query: 725  KIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPS 784
            KIHE M  ED +  LQ D+SVLQ++  ++EN+N+++G+E+ NLTKELE  + +S++LRPS
Sbjct: 730  KIHELMNKEDQLSQLQVDYSVLQQRFMEEENKNKNMGQEVLNLTKELELSKRYSRALRPS 789

Query: 785  LNGRRISDPQVFSKEVQTEAVDNEPPDYKSLIPLERAVINGQLYEESENQD---EDPNDE 841
            +NGRR+ D  V S  VQT+AV  E  + ++     R     + +  S  +    + P + 
Sbjct: 790  VNGRRMVDVPVTSTGVQTDAVSGEAAEEETPAVFIRKSFQEENHIMSNLRQVGLKKPVER 849

Query: 842  GSVLSFKCSQSTPCPVNRKLWIPWMKSKE-GHLQNGKMQTKPNANFVQPGDLVLSHTPGQ 900
             SVL      +    + RK WIPWM+ +E G     +   + N++   PG++VLS   GQ
Sbjct: 850  SSVLDRYPPAANELTM-RKSWIPWMRKRENGPSITQEKGPRTNSSPGHPGEVVLSPKQGQ 908

Query: 901  PLHIKVTPDHVQNTATLEITSPTTESPHSYTSTAVIPNCGTPKQRITILQNASITPVKSK 960
            PLHI+VTPDH  +TATLEITSPT+E    ++ST VIP  G  K RITI+ + ++ P K K
Sbjct: 909  PLHIRVTPDHENSTATLEITSPTSE--EFFSSTTVIPTLGNQKPRITIIPSPNVMPQKQK 966

Query: 961  TSTEDLMNLEQGMSPITMATFARAQTPESCGSLTPERTMSPIQVLAVTGSASSPEQGRSP 1020
             S +  +  E+ MSP+T+ TF+R +TPES      +R  SPIQ++ V+ SA+  E   SP
Sbjct: 967  -SGDTTLGPERAMSPVTITTFSREKTPESGRGAFADRPTSPIQIMTVSTSAAPAEIAVSP 1025

Query: 1021 EPTEISAKHAIFRVSPDRQSSWQFQRSNSNSSSVITTEDNKIHIHLGSPYMQAVASP--- 1077
            E  E+     I +V+P++Q+     R  ++++++ITTEDNKIHIHLGS + ++  +    
Sbjct: 1026 ESQEMPMGRTILKVTPEKQTVPTPVRKYNSNANIITTEDNKIHIHLGSQFKRSPGTSGEG 1085

Query: 1078 VRPASPSAPLQDNRTQGLINGALNKT----------TNKVTSSITITPTATPLPRQSQ 1125
            V P     P+     + +  G + ++           +KVTS+ITITP  T   R +Q
Sbjct: 1086 VSPVITVRPVNVTAEKEVSTGTVLRSPRNHLSSRPGASKVTSTITITPVTTSSARGTQ 1143


>gi|216548091 leucine zipper protein 1 [Homo sapiens]
          Length = 1076

 Score =  259 bits (662), Expect = 1e-68
 Identities = 152/423 (35%), Positives = 262/423 (61%), Gaps = 43/423 (10%)

Query: 310 MAKLTN--EDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAG 367
           MA+ T+  E + +R L+ KL +LSR++DELEE  ++L+KAE+EL D+++K+ + E  N+ 
Sbjct: 1   MAEFTSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSS 60

Query: 368 IMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMAL 427
           ++AE+E LR+RVL +EGKDEE+ + E+ CR + ++LE E   +++ K E+E+L KR+  L
Sbjct: 61  MLAEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAEL 120

Query: 428 EKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLK 487
           EKLE+AF++SK +C  L  +L +ER  TK++S ELE L+V++KELE+ E RL+KTE +L 
Sbjct: 121 EKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLA 180

Query: 488 EDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRAL 547
            +L KLK+LT+ FV ERK ++EK K+ E  ++  + +L  EQNK         +  +   
Sbjct: 181 SELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKL--EQNK---------KMNRDYT 229

Query: 548 KSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKL 607
           ++ +++E             +N L+ E+   + L S+ +  K  L  L+ +E +  +NK 
Sbjct: 230 RNASNLE-------------RNDLRIEDGISSTLPSKESRRKGGLDYLKQVENE-TRNKS 275

Query: 608 NQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANER 667
             +  +     +QE+NK+K+L+QE+E+LK ++K  +++E++L K + +   L+  Y +E+
Sbjct: 276 ENEKNR-----NQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQ 330

Query: 668 DKAQFLSKELEHVKMELAKYKLAEKTETS-----------HEQWLFKRLQEEEAKSGHLS 716
           +K + L+ +LE +K+++ K K  E  E             HE+  F+    E + S H +
Sbjct: 331 NKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTA 390

Query: 717 REV 719
           RE+
Sbjct: 391 REL 393



 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 96/395 (24%), Positives = 183/395 (46%), Gaps = 55/395 (13%)

Query: 450 KERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSE 509
           KE  +++ L  +L+SL  R+ ELE     L+K E                  DE   + +
Sbjct: 8   KETASSRHLRFKLQSLSRRLDELEEATKNLQKAE------------------DELLDLQD 49

Query: 510 KLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKN 569
           K+ + E    +  ++++V + +V  +  K  EE KRA        E +  + KE      
Sbjct: 50  KVIQAEGSNSSMLAEIEVLRQRVLRIEGK-DEEIKRA--------EDLCRLMKE------ 94

Query: 570 KLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELS 629
           KL+ EE    +L S +  L+ R+  LE +E+ F ++K   D  +   +L++E N  K++S
Sbjct: 95  KLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSK--NDCTQLCLSLNEERNLTKKIS 152

Query: 630 QEVERLKLKLKDMKAIEDDLMKTED----EYETL---------ERRYANERDKAQFLSKE 676
            E+E L++K+K++++ ED L KTE     E E L         ER+Y NE++K     K 
Sbjct: 153 SELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKEN--EKL 210

Query: 677 LEHVKMELAKYKLAEKTETSHEQWLFKR-LQEEEAKSGHLSREVDALKEKIHEYMATEDL 735
           ++ +  +L + K   +  T +   L +  L+ E+  S  L  +    K  +      E+ 
Sbjct: 211 IKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENE 270

Query: 736 ICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPSLNGRRISDPQV 795
                 + S  +K  NQ++N+ +DL +EIE L  +++ +    + L+   +         
Sbjct: 271 T----RNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNY 326

Query: 796 FSKEVQTEAVDNEPPDYKSLIPLERAVINGQLYEE 830
            S++ + + + ++  + K  I  ++ + NG++  E
Sbjct: 327 LSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGE 361



 Score = 77.8 bits (190), Expect = 5e-14
 Identities = 96/431 (22%), Positives = 183/431 (42%), Gaps = 51/431 (11%)

Query: 191 EFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLT 250
           EF    E    R  +   Q +  + ++ +E  K +   ++EL  L+   +        + 
Sbjct: 3   EFTSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSML 62

Query: 251 AQLTLQRQKIQELTTNAKETHTKLA-----LAEARVQEEEQKATRLEKE----------- 294
           A++ + RQ++  L    K+   K A     L + +++EEE     L+ E           
Sbjct: 63  AEIEVLRQRV--LRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAEL 120

Query: 295 --LQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQ 352
             L+   ++   D   +   L  E +  +++  +L  L  ++ ELE +   L K E+ L 
Sbjct: 121 EKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLA 180

Query: 353 DIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERE------ 406
              EK+         +       RK + + E ++E+LIK   Q  + NK++ R+      
Sbjct: 181 SELEKLK-------SLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNAS 233

Query: 407 TLQSKDFKLE-------VEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLS 459
            L+  D ++E         K S+R   L+ L+   N+++ +  + K N  +E    K L+
Sbjct: 234 NLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEK-NRNQEDNKVKDLN 292

Query: 460 QELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLK--KTEDK 517
           QE+E LK +IK  E++E  L+K    +K     L+   +   ++ K ++ +L+  K + K
Sbjct: 293 QEIEKLKTQIKHFESLEEELKK----MKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIK 348

Query: 518 LQAASSQLQVEQNKVTTVTEKLIEETK-RALKSKTDVEE---KMYSVTKERDDLKNKLKA 573
            Q      +VE       ++   E TK R   S+  V +   +  S   +R+ L+N+  A
Sbjct: 349 KQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFA 408

Query: 574 EEEKGNDLLSR 584
              +   L +R
Sbjct: 409 LNNENYSLSNR 419



 Score = 70.5 bits (171), Expect = 9e-12
 Identities = 66/277 (23%), Positives = 128/277 (46%), Gaps = 25/277 (9%)

Query: 514 TEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKA 573
           T  K  A+S  L+ +   ++   ++L E TK   K++ ++            DL++K+  
Sbjct: 5   TSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELL-----------DLQDKVIQ 53

Query: 574 EEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGK-STTALHQENNKIKELSQEV 632
            E   + +L+ + +L+ R+  +E  +++    K  +D  +     L +E N  +EL  E+
Sbjct: 54  AEGSNSSMLAEIEVLRQRVLRIEGKDEEI---KRAEDLCRLMKEKLEEEENLTRELKSEI 110

Query: 633 ERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEK 692
           ERL+ ++ +++ +E+   +++++   L      ER+  + +S ELE +++++ + + +E 
Sbjct: 111 ERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSED 170

Query: 693 TETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQ 752
                EQ L   L++ ++ +     E   L EK  E    E LI         L +KL Q
Sbjct: 171 RLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKE---NEKLI-------KELTQKLEQ 220

Query: 753 QENRNRDLGREIENLTKELERYRHFSKSLRPSLNGRR 789
            +  NRD  R   NL +   R      S  PS   RR
Sbjct: 221 NKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRR 257



 Score = 70.5 bits (171), Expect = 9e-12
 Identities = 83/414 (20%), Positives = 165/414 (39%), Gaps = 59/414 (14%)

Query: 149 KHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEF----------ICLLEQ 198
           K  E   R++ + L  E++  + +    E  +K    +EK +E           +CL   
Sbjct: 83  KRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLN 142

Query: 199 ECERLKKLIDQE-------IKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTA 251
           E   L K I  E       +K  E  E   +K   +L  EL KLKS  L  V E++ L  
Sbjct: 143 EERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNE 202

Query: 252 QLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMA 311
           +     + I+ELT   ++            ++  +  TR    L+    +    +D I +
Sbjct: 203 KEKENEKLIKELTQKLEQN-----------KKMNRDYTRNASNLERNDLRI---EDGISS 248

Query: 312 KLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAE 371
            L +++S+ +     L  +  +     E  ++  + + +++D+ +              E
Sbjct: 249 TLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQ--------------E 294

Query: 372 VEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLE 431
           +E+L+ ++   E  +EEL KM+ +  DL      E  ++K    ++E++  +I   ++LE
Sbjct: 295 IEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELE 354

Query: 432 DAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKED-- 489
           +   + +    S K   E+ +         +     R    +    RL   EF L  +  
Sbjct: 355 NGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFALNNENY 414

Query: 490 -LTKLKTLTVMFVDERKTM-----------SEKLKKTEDKLQAASSQLQVEQNK 531
            L+  +  +  F + R              +++ KKTED+    SSQ + ++++
Sbjct: 415 SLSNRQVSSPSFTNRRAAKASHMGVSTDSGTQETKKTEDRFVPGSSQSEGKKSR 468


>gi|216548085 leucine zipper protein 1 [Homo sapiens]
          Length = 1076

 Score =  259 bits (662), Expect = 1e-68
 Identities = 152/423 (35%), Positives = 262/423 (61%), Gaps = 43/423 (10%)

Query: 310 MAKLTN--EDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAG 367
           MA+ T+  E + +R L+ KL +LSR++DELEE  ++L+KAE+EL D+++K+ + E  N+ 
Sbjct: 1   MAEFTSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSS 60

Query: 368 IMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMAL 427
           ++AE+E LR+RVL +EGKDEE+ + E+ CR + ++LE E   +++ K E+E+L KR+  L
Sbjct: 61  MLAEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAEL 120

Query: 428 EKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLK 487
           EKLE+AF++SK +C  L  +L +ER  TK++S ELE L+V++KELE+ E RL+KTE +L 
Sbjct: 121 EKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLA 180

Query: 488 EDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRAL 547
            +L KLK+LT+ FV ERK ++EK K+ E  ++  + +L  EQNK         +  +   
Sbjct: 181 SELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKL--EQNK---------KMNRDYT 229

Query: 548 KSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKL 607
           ++ +++E             +N L+ E+   + L S+ +  K  L  L+ +E +  +NK 
Sbjct: 230 RNASNLE-------------RNDLRIEDGISSTLPSKESRRKGGLDYLKQVENE-TRNKS 275

Query: 608 NQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANER 667
             +  +     +QE+NK+K+L+QE+E+LK ++K  +++E++L K + +   L+  Y +E+
Sbjct: 276 ENEKNR-----NQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQ 330

Query: 668 DKAQFLSKELEHVKMELAKYKLAEKTETS-----------HEQWLFKRLQEEEAKSGHLS 716
           +K + L+ +LE +K+++ K K  E  E             HE+  F+    E + S H +
Sbjct: 331 NKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTA 390

Query: 717 REV 719
           RE+
Sbjct: 391 REL 393



 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 96/395 (24%), Positives = 183/395 (46%), Gaps = 55/395 (13%)

Query: 450 KERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSE 509
           KE  +++ L  +L+SL  R+ ELE     L+K E                  DE   + +
Sbjct: 8   KETASSRHLRFKLQSLSRRLDELEEATKNLQKAE------------------DELLDLQD 49

Query: 510 KLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKN 569
           K+ + E    +  ++++V + +V  +  K  EE KRA        E +  + KE      
Sbjct: 50  KVIQAEGSNSSMLAEIEVLRQRVLRIEGK-DEEIKRA--------EDLCRLMKE------ 94

Query: 570 KLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELS 629
           KL+ EE    +L S +  L+ R+  LE +E+ F ++K   D  +   +L++E N  K++S
Sbjct: 95  KLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSK--NDCTQLCLSLNEERNLTKKIS 152

Query: 630 QEVERLKLKLKDMKAIEDDLMKTED----EYETL---------ERRYANERDKAQFLSKE 676
            E+E L++K+K++++ ED L KTE     E E L         ER+Y NE++K     K 
Sbjct: 153 SELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKEN--EKL 210

Query: 677 LEHVKMELAKYKLAEKTETSHEQWLFKR-LQEEEAKSGHLSREVDALKEKIHEYMATEDL 735
           ++ +  +L + K   +  T +   L +  L+ E+  S  L  +    K  +      E+ 
Sbjct: 211 IKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENE 270

Query: 736 ICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPSLNGRRISDPQV 795
                 + S  +K  NQ++N+ +DL +EIE L  +++ +    + L+   +         
Sbjct: 271 T----RNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNY 326

Query: 796 FSKEVQTEAVDNEPPDYKSLIPLERAVINGQLYEE 830
            S++ + + + ++  + K  I  ++ + NG++  E
Sbjct: 327 LSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGE 361



 Score = 77.8 bits (190), Expect = 5e-14
 Identities = 96/431 (22%), Positives = 183/431 (42%), Gaps = 51/431 (11%)

Query: 191 EFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLT 250
           EF    E    R  +   Q +  + ++ +E  K +   ++EL  L+   +        + 
Sbjct: 3   EFTSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSML 62

Query: 251 AQLTLQRQKIQELTTNAKETHTKLA-----LAEARVQEEEQKATRLEKE----------- 294
           A++ + RQ++  L    K+   K A     L + +++EEE     L+ E           
Sbjct: 63  AEIEVLRQRV--LRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAEL 120

Query: 295 --LQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQ 352
             L+   ++   D   +   L  E +  +++  +L  L  ++ ELE +   L K E+ L 
Sbjct: 121 EKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLA 180

Query: 353 DIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERE------ 406
              EK+         +       RK + + E ++E+LIK   Q  + NK++ R+      
Sbjct: 181 SELEKLK-------SLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNAS 233

Query: 407 TLQSKDFKLE-------VEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLS 459
            L+  D ++E         K S+R   L+ L+   N+++ +  + K N  +E    K L+
Sbjct: 234 NLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEK-NRNQEDNKVKDLN 292

Query: 460 QELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLK--KTEDK 517
           QE+E LK +IK  E++E  L+K    +K     L+   +   ++ K ++ +L+  K + K
Sbjct: 293 QEIEKLKTQIKHFESLEEELKK----MKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIK 348

Query: 518 LQAASSQLQVEQNKVTTVTEKLIEETK-RALKSKTDVEE---KMYSVTKERDDLKNKLKA 573
            Q      +VE       ++   E TK R   S+  V +   +  S   +R+ L+N+  A
Sbjct: 349 KQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFA 408

Query: 574 EEEKGNDLLSR 584
              +   L +R
Sbjct: 409 LNNENYSLSNR 419



 Score = 70.5 bits (171), Expect = 9e-12
 Identities = 66/277 (23%), Positives = 128/277 (46%), Gaps = 25/277 (9%)

Query: 514 TEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKA 573
           T  K  A+S  L+ +   ++   ++L E TK   K++ ++            DL++K+  
Sbjct: 5   TSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELL-----------DLQDKVIQ 53

Query: 574 EEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGK-STTALHQENNKIKELSQEV 632
            E   + +L+ + +L+ R+  +E  +++    K  +D  +     L +E N  +EL  E+
Sbjct: 54  AEGSNSSMLAEIEVLRQRVLRIEGKDEEI---KRAEDLCRLMKEKLEEEENLTRELKSEI 110

Query: 633 ERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEK 692
           ERL+ ++ +++ +E+   +++++   L      ER+  + +S ELE +++++ + + +E 
Sbjct: 111 ERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSED 170

Query: 693 TETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQ 752
                EQ L   L++ ++ +     E   L EK  E    E LI         L +KL Q
Sbjct: 171 RLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKE---NEKLI-------KELTQKLEQ 220

Query: 753 QENRNRDLGREIENLTKELERYRHFSKSLRPSLNGRR 789
            +  NRD  R   NL +   R      S  PS   RR
Sbjct: 221 NKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRR 257



 Score = 70.5 bits (171), Expect = 9e-12
 Identities = 83/414 (20%), Positives = 165/414 (39%), Gaps = 59/414 (14%)

Query: 149 KHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEF----------ICLLEQ 198
           K  E   R++ + L  E++  + +    E  +K    +EK +E           +CL   
Sbjct: 83  KRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLN 142

Query: 199 ECERLKKLIDQE-------IKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTA 251
           E   L K I  E       +K  E  E   +K   +L  EL KLKS  L  V E++ L  
Sbjct: 143 EERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNE 202

Query: 252 QLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMA 311
           +     + I+ELT   ++            ++  +  TR    L+    +    +D I +
Sbjct: 203 KEKENEKLIKELTQKLEQN-----------KKMNRDYTRNASNLERNDLRI---EDGISS 248

Query: 312 KLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAE 371
            L +++S+ +     L  +  +     E  ++  + + +++D+ +              E
Sbjct: 249 TLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQ--------------E 294

Query: 372 VEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLE 431
           +E+L+ ++   E  +EEL KM+ +  DL      E  ++K    ++E++  +I   ++LE
Sbjct: 295 IEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELE 354

Query: 432 DAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKED-- 489
           +   + +    S K   E+ +         +     R    +    RL   EF L  +  
Sbjct: 355 NGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFALNNENY 414

Query: 490 -LTKLKTLTVMFVDERKTM-----------SEKLKKTEDKLQAASSQLQVEQNK 531
            L+  +  +  F + R              +++ KKTED+    SSQ + ++++
Sbjct: 415 SLSNRQVSSPSFTNRRAAKASHMGVSTDSGTQETKKTEDRFVPGSSQSEGKKSR 468


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score =  146 bits (368), Expect = 1e-34
 Identities = 192/788 (24%), Positives = 345/788 (43%), Gaps = 137/788 (17%)

Query: 109  FVTPKKVLEAL-QRDAFQAKSTPWQE--DIYEKPMNELDKVVEKHKESYRRILGQLLVAE 165
            F   K +L+   Q +  QAK    Q+  +  +K  NEL ++ +KH +       + L+ E
Sbjct: 838  FTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEE---KNLLQE 894

Query: 166  KSRRQTILELEEEKR------KHKEYMEKSDEFICLLEQECER-------LKKLIDQEIK 212
            + + +T L  E E+       K +E  E   E    LE+E +R        KK+  Q + 
Sbjct: 895  QLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLD 954

Query: 213  SQEEKEQEKEKRVTTLKEELT------KLKSFALMVVDEQQRLTAQLTLQRQKIQELTTN 266
             +E+ E+E+  R     E++T      KL+   L++ D+  +L+ +  L  ++I +LTTN
Sbjct: 955  LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1014

Query: 267  AKETHTK--------------LALAEARVQEEEQKATRLEK---ELQTQTTKFHQDQDTI 309
              E   K              ++  E R+++EE+    LEK   +L+   + FH+    +
Sbjct: 1015 LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADL 1074

Query: 310  MAKLTNEDSQNRQLQQKL-AALSRQIDELEETNRSLRKAEE---ELQDIKEKI------- 358
             A++     Q  + +++L AAL+R  DE+ + N +L+K  E    + D++E +       
Sbjct: 1075 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR 1134

Query: 359  SKGEYGNAGIMAEVEELRKRV---LDMEGKDEEL-IKMEEQCRDLNKRLERETLQSKDFK 414
            +K E     +  E+E L+  +   LD     +EL  K E++   L K L+ ET +S + +
Sbjct: 1135 NKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEET-RSHEAQ 1193

Query: 415  LE---------VEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELE-- 463
            ++         VE+L++++   ++ +   +K+KQ       +L  E     Q  QE+E  
Sbjct: 1194 VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHK 1253

Query: 464  --SLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAA 521
               L+ +++EL++  S  E+    L + + KL+               K  K    + + 
Sbjct: 1254 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1313

Query: 522  SSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDL 581
            SSQLQ  Q       E L EET++    K +V  K+  + +ER+ L+++L  E E   +L
Sbjct: 1314 SSQLQDTQ-------ELLQEETRQ----KLNVSTKLRQLEEERNSLQDQLDEEMEAKQNL 1362

Query: 582  LSRVNML-------KNRLQ----SLEAIE---KDFLK--NKLNQDSGKSTTALHQENNKI 625
               ++ L       K +LQ    ++EA+E   K F K    L Q   +   A  +     
Sbjct: 1363 ERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK 1422

Query: 626  KELSQEVERLKLKLKDMKAIEDDLMKTEDEYETL-------ERRYANERDKAQFLSKELE 678
              L QE++ L + L + + +  +L K + +++ L         +YA+ERD+A+  ++E E
Sbjct: 1423 NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1482

Query: 679  HVKMELAKYKLAEKTETSHE-------------------QWLFKRLQEEEAKSGHLSREV 719
               + LA+  L E  E   E                     + K + E E     L  ++
Sbjct: 1483 TKALSLAR-ALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM 1541

Query: 720  DALKEKIH----EYMATEDLICHLQGDHSV--------LQKKLNQQENRNRDLGREIENL 767
            + +K ++     E  ATED    L+ +           LQ +  Q E + R L R++   
Sbjct: 1542 EEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEY 1601

Query: 768  TKELERYR 775
              ELE  R
Sbjct: 1602 ETELEDER 1609



 Score =  127 bits (319), Expect = 6e-29
 Identities = 157/696 (22%), Positives = 302/696 (43%), Gaps = 86/696 (12%)

Query: 137  EKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICLL 196
            EK   EL+K+  K +        Q+   +    +  ++L +++ + +  + + D+ I   
Sbjct: 1047 EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQK 1106

Query: 197  EQECERLKKL------IDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLT 250
                +++++L      + +++ S+     + EK+   L EEL  LK+    + D      
Sbjct: 1107 NNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKT---ELEDTLDSTA 1163

Query: 251  AQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIM 310
             Q  L+ ++ QE+T   K    +    EA+VQE  QK  +  +EL  Q  +F + +  + 
Sbjct: 1164 TQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD 1223

Query: 311  AKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMA 370
                  + +N  L  +L  L +   E+E      +K E ++Q+++ K S GE   A +  
Sbjct: 1224 KNKQTLEKENADLAGELRVLGQAKQEVEHKK---KKLEAQVQELQSKCSDGERARAELND 1280

Query: 371  EVEELRKRV-------LDMEGKDEELIK----MEEQCRDLNKRLERETLQ-----SKDFK 414
            +V +L+  V        + EGK  +L K    +  Q +D  + L+ ET Q     +K  +
Sbjct: 1281 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1340

Query: 415  LEVEKLSKRIMALEKLEDAFN-------------KSKQECYSLKCNLEKERMTTKQLSQE 461
            LE E+ S +    E++E   N              SK++       +E      K+  +E
Sbjct: 1341 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE 1400

Query: 462  LESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAA 521
            +E+L  + +E  A   +LEKT+  L+++L  L    V+ +D ++ +   L+K + K    
Sbjct: 1401 IENLTQQYEEKAAAYDKLEKTKNRLQQELDDL----VVDLDNQRQLVSNLEKKQRKF--- 1453

Query: 522  SSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDL 581
              QL  E+  +++   K  +E  RA     + E K  S+ +    L+  L+A+EE     
Sbjct: 1454 -DQLLAEEKNISS---KYADERDRAEAEAREKETKALSLARA---LEEALEAKEE----- 1501

Query: 582  LSRVN-MLKNRLQSLEAIEKDFLKN--KLNQDSGKSTTALHQENNKIKELSQEVE----- 633
            L R N MLK  ++ L + + D  KN  +L +      T + +   +++EL  E++     
Sbjct: 1502 LERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDA 1561

Query: 634  --RLKLKLKDMKA-IEDDLMKTEDEYETLERR-----------YANERDKAQFLSKELEH 679
              RL++ ++ +K   E DL   +++ E   R+             +ER +    +   + 
Sbjct: 1562 KLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKK 1621

Query: 680  VKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMAT----EDL 735
            ++ +L   +L   +     +   K+L++ +A+     RE++  +    E  AT    E  
Sbjct: 1622 LEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKK 1681

Query: 736  ICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKEL 771
               L+ D   LQ+ L   E   +    E E L +EL
Sbjct: 1682 AKSLEADLMQLQEDLAAAERARKQADLEKEELAEEL 1717



 Score =  121 bits (303), Expect = 4e-27
 Identities = 151/660 (22%), Positives = 288/660 (43%), Gaps = 61/660 (9%)

Query: 132  QEDIYEKPMNELD-----KVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYM 186
            QE + E+   +L+     + +E+ + S +  L + + A+++  + I  L  +    K+ +
Sbjct: 1321 QELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL 1380

Query: 187  EKSDEFICLLEQECERLKKLIDQEIKSQEEKE---QEKEKRVTTLKEELTKLKSFALMVV 243
            +     +  LE+  +R +K I+   +  EEK     + EK    L++EL  L    ++ +
Sbjct: 1381 QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL----VVDL 1436

Query: 244  DEQQRLTAQLTLQRQKIQELTTNAKETHTKLA----LAEARVQEEEQKATRLEKELQTQT 299
            D Q++L + L  +++K  +L    K   +K A     AEA  +E+E KA  L + L+   
Sbjct: 1437 DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL 1496

Query: 300  -TKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEE----LQDI 354
              K   ++   M K   ED     L      + + + ELE++ R+L    EE    L+++
Sbjct: 1497 EAKEELERTNKMLKAEMED-----LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1551

Query: 355  KEKISKGEYGNAGIMAEVEELRKRV-LDMEGKDEELIKMEEQCRDLNKRLERETLQSKDF 413
            ++++   E     +   ++ L+ +   D++ +DE+    EE+ R L ++L     + +D 
Sbjct: 1552 EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ---NEEKRRQLQRQLHEYETELEDE 1608

Query: 414  KLE-------VEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLK 466
            + +        +KL   +  LE   D+  K ++E       L K +   K   +ELE  +
Sbjct: 1609 RKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIK---QLRKLQAQMKDFQRELEDAR 1665

Query: 467  VRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASS--- 523
                E+ A     EK   +L+ DL +L+    +   ER      L+K E   + ASS   
Sbjct: 1666 ASRDEIFATAKENEKKAKSLEADLMQLQE--DLAAAERARKQADLEKEELAEELASSLSG 1723

Query: 524  --QLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEE------ 575
               LQ E+ ++     +L EE +    +   + +++   T++ + L N+L  E       
Sbjct: 1724 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 1783

Query: 576  EKGNDLLSRVNM-LKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVER 634
            E     L R N  L+++L  +E   K   K+ +     K      Q   + +E     + 
Sbjct: 1784 ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKS 1843

Query: 635  LKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTE 694
            LK K K +K I   L++ EDE +  E+ Y  + +K     K+L   K +L + +   +  
Sbjct: 1844 LKQKDKKLKEI---LLQVEDERKMAEQ-YKEQAEKGNARVKQL---KRQLEEAEEESQRI 1896

Query: 695  TSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQE 754
             ++ + L + L E    +  + REV+ALK K+     T  +     G   V++     +E
Sbjct: 1897 NANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENADGSEE 1956



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 75/370 (20%), Positives = 155/370 (41%), Gaps = 43/370 (11%)

Query: 80   EGELQARDEVIGILKAE-KMDLALLEAQYGFVTPKKVLEALQRDAFQA--KSTPWQEDIY 136
            E +LQARDE     + + +  L   E +      ++ L A  +   +   K    Q D  
Sbjct: 1577 ERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSA 1636

Query: 137  EKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHK----EYMEKSDEF 192
             K   E  K + K +   +    +L  A  SR +     +E ++K K    + M+  ++ 
Sbjct: 1637 IKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDL 1696

Query: 193  ICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQ 252
                    ER +K  D E +   E+          L++E  +L++    + +E +     
Sbjct: 1697 AA-----AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGN 1751

Query: 253  LTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAK 312
            +     ++++ T  A++   +LA   +  Q+ E    +LE++ +   +K H+ +  + +K
Sbjct: 1752 MEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSK 1811

Query: 313  LTNEDSQNRQLQQKLAALSRQID----ELEETNRSLRKAEEELQDI-------------- 354
                 S    L+ K+A L  Q++    E +   +SL++ +++L++I              
Sbjct: 1812 F---KSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQY 1868

Query: 355  KEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFK 414
            KE+  KG        A V++L+++   +E  +EE  ++    R L + L+  T  ++   
Sbjct: 1869 KEQAEKGN-------ARVKQLKRQ---LEEAEEESQRINANRRKLQRELDEATESNEAMG 1918

Query: 415  LEVEKLSKRI 424
             EV  L  ++
Sbjct: 1919 REVNALKSKL 1928


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score =  146 bits (368), Expect = 1e-34
 Identities = 192/788 (24%), Positives = 345/788 (43%), Gaps = 137/788 (17%)

Query: 109  FVTPKKVLEAL-QRDAFQAKSTPWQE--DIYEKPMNELDKVVEKHKESYRRILGQLLVAE 165
            F   K +L+   Q +  QAK    Q+  +  +K  NEL ++ +KH +       + L+ E
Sbjct: 845  FTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEE---KNLLQE 901

Query: 166  KSRRQTILELEEEKR------KHKEYMEKSDEFICLLEQECER-------LKKLIDQEIK 212
            + + +T L  E E+       K +E  E   E    LE+E +R        KK+  Q + 
Sbjct: 902  QLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLD 961

Query: 213  SQEEKEQEKEKRVTTLKEELT------KLKSFALMVVDEQQRLTAQLTLQRQKIQELTTN 266
             +E+ E+E+  R     E++T      KL+   L++ D+  +L+ +  L  ++I +LTTN
Sbjct: 962  LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1021

Query: 267  AKETHTK--------------LALAEARVQEEEQKATRLEK---ELQTQTTKFHQDQDTI 309
              E   K              ++  E R+++EE+    LEK   +L+   + FH+    +
Sbjct: 1022 LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADL 1081

Query: 310  MAKLTNEDSQNRQLQQKL-AALSRQIDELEETNRSLRKAEE---ELQDIKEKI------- 358
             A++     Q  + +++L AAL+R  DE+ + N +L+K  E    + D++E +       
Sbjct: 1082 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR 1141

Query: 359  SKGEYGNAGIMAEVEELRKRV---LDMEGKDEEL-IKMEEQCRDLNKRLERETLQSKDFK 414
            +K E     +  E+E L+  +   LD     +EL  K E++   L K L+ ET +S + +
Sbjct: 1142 NKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEET-RSHEAQ 1200

Query: 415  LE---------VEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELE-- 463
            ++         VE+L++++   ++ +   +K+KQ       +L  E     Q  QE+E  
Sbjct: 1201 VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHK 1260

Query: 464  --SLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAA 521
               L+ +++EL++  S  E+    L + + KL+               K  K    + + 
Sbjct: 1261 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1320

Query: 522  SSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDL 581
            SSQLQ  Q       E L EET++    K +V  K+  + +ER+ L+++L  E E   +L
Sbjct: 1321 SSQLQDTQ-------ELLQEETRQ----KLNVSTKLRQLEEERNSLQDQLDEEMEAKQNL 1369

Query: 582  LSRVNML-------KNRLQ----SLEAIE---KDFLK--NKLNQDSGKSTTALHQENNKI 625
               ++ L       K +LQ    ++EA+E   K F K    L Q   +   A  +     
Sbjct: 1370 ERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK 1429

Query: 626  KELSQEVERLKLKLKDMKAIEDDLMKTEDEYETL-------ERRYANERDKAQFLSKELE 678
              L QE++ L + L + + +  +L K + +++ L         +YA+ERD+A+  ++E E
Sbjct: 1430 NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1489

Query: 679  HVKMELAKYKLAEKTETSHE-------------------QWLFKRLQEEEAKSGHLSREV 719
               + LA+  L E  E   E                     + K + E E     L  ++
Sbjct: 1490 TKALSLAR-ALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM 1548

Query: 720  DALKEKIH----EYMATEDLICHLQGDHSV--------LQKKLNQQENRNRDLGREIENL 767
            + +K ++     E  ATED    L+ +           LQ +  Q E + R L R++   
Sbjct: 1549 EEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEY 1608

Query: 768  TKELERYR 775
              ELE  R
Sbjct: 1609 ETELEDER 1616



 Score =  127 bits (319), Expect = 6e-29
 Identities = 157/696 (22%), Positives = 302/696 (43%), Gaps = 86/696 (12%)

Query: 137  EKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICLL 196
            EK   EL+K+  K +        Q+   +    +  ++L +++ + +  + + D+ I   
Sbjct: 1054 EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQK 1113

Query: 197  EQECERLKKL------IDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLT 250
                +++++L      + +++ S+     + EK+   L EEL  LK+    + D      
Sbjct: 1114 NNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKT---ELEDTLDSTA 1170

Query: 251  AQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIM 310
             Q  L+ ++ QE+T   K    +    EA+VQE  QK  +  +EL  Q  +F + +  + 
Sbjct: 1171 TQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD 1230

Query: 311  AKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMA 370
                  + +N  L  +L  L +   E+E      +K E ++Q+++ K S GE   A +  
Sbjct: 1231 KNKQTLEKENADLAGELRVLGQAKQEVEHKK---KKLEAQVQELQSKCSDGERARAELND 1287

Query: 371  EVEELRKRV-------LDMEGKDEELIK----MEEQCRDLNKRLERETLQ-----SKDFK 414
            +V +L+  V        + EGK  +L K    +  Q +D  + L+ ET Q     +K  +
Sbjct: 1288 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1347

Query: 415  LEVEKLSKRIMALEKLEDAFN-------------KSKQECYSLKCNLEKERMTTKQLSQE 461
            LE E+ S +    E++E   N              SK++       +E      K+  +E
Sbjct: 1348 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE 1407

Query: 462  LESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAA 521
            +E+L  + +E  A   +LEKT+  L+++L  L    V+ +D ++ +   L+K + K    
Sbjct: 1408 IENLTQQYEEKAAAYDKLEKTKNRLQQELDDL----VVDLDNQRQLVSNLEKKQRKF--- 1460

Query: 522  SSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDL 581
              QL  E+  +++   K  +E  RA     + E K  S+ +    L+  L+A+EE     
Sbjct: 1461 -DQLLAEEKNISS---KYADERDRAEAEAREKETKALSLARA---LEEALEAKEE----- 1508

Query: 582  LSRVN-MLKNRLQSLEAIEKDFLKN--KLNQDSGKSTTALHQENNKIKELSQEVE----- 633
            L R N MLK  ++ L + + D  KN  +L +      T + +   +++EL  E++     
Sbjct: 1509 LERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDA 1568

Query: 634  --RLKLKLKDMKA-IEDDLMKTEDEYETLERR-----------YANERDKAQFLSKELEH 679
              RL++ ++ +K   E DL   +++ E   R+             +ER +    +   + 
Sbjct: 1569 KLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKK 1628

Query: 680  VKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMAT----EDL 735
            ++ +L   +L   +     +   K+L++ +A+     RE++  +    E  AT    E  
Sbjct: 1629 LEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKK 1688

Query: 736  ICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKEL 771
               L+ D   LQ+ L   E   +    E E L +EL
Sbjct: 1689 AKSLEADLMQLQEDLAAAERARKQADLEKEELAEEL 1724



 Score =  121 bits (303), Expect = 4e-27
 Identities = 151/660 (22%), Positives = 288/660 (43%), Gaps = 61/660 (9%)

Query: 132  QEDIYEKPMNELD-----KVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYM 186
            QE + E+   +L+     + +E+ + S +  L + + A+++  + I  L  +    K+ +
Sbjct: 1328 QELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL 1387

Query: 187  EKSDEFICLLEQECERLKKLIDQEIKSQEEKE---QEKEKRVTTLKEELTKLKSFALMVV 243
            +     +  LE+  +R +K I+   +  EEK     + EK    L++EL  L    ++ +
Sbjct: 1388 QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL----VVDL 1443

Query: 244  DEQQRLTAQLTLQRQKIQELTTNAKETHTKLA----LAEARVQEEEQKATRLEKELQTQT 299
            D Q++L + L  +++K  +L    K   +K A     AEA  +E+E KA  L + L+   
Sbjct: 1444 DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL 1503

Query: 300  -TKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEE----LQDI 354
              K   ++   M K   ED     L      + + + ELE++ R+L    EE    L+++
Sbjct: 1504 EAKEELERTNKMLKAEMED-----LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1558

Query: 355  KEKISKGEYGNAGIMAEVEELRKRV-LDMEGKDEELIKMEEQCRDLNKRLERETLQSKDF 413
            ++++   E     +   ++ L+ +   D++ +DE+    EE+ R L ++L     + +D 
Sbjct: 1559 EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ---NEEKRRQLQRQLHEYETELEDE 1615

Query: 414  KLE-------VEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLK 466
            + +        +KL   +  LE   D+  K ++E       L K +   K   +ELE  +
Sbjct: 1616 RKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIK---QLRKLQAQMKDFQRELEDAR 1672

Query: 467  VRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASS--- 523
                E+ A     EK   +L+ DL +L+    +   ER      L+K E   + ASS   
Sbjct: 1673 ASRDEIFATAKENEKKAKSLEADLMQLQE--DLAAAERARKQADLEKEELAEELASSLSG 1730

Query: 524  --QLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEE------ 575
               LQ E+ ++     +L EE +    +   + +++   T++ + L N+L  E       
Sbjct: 1731 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 1790

Query: 576  EKGNDLLSRVNM-LKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVER 634
            E     L R N  L+++L  +E   K   K+ +     K      Q   + +E     + 
Sbjct: 1791 ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKS 1850

Query: 635  LKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTE 694
            LK K K +K I   L++ EDE +  E+ Y  + +K     K+L   K +L + +   +  
Sbjct: 1851 LKQKDKKLKEI---LLQVEDERKMAEQ-YKEQAEKGNARVKQL---KRQLEEAEEESQRI 1903

Query: 695  TSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQE 754
             ++ + L + L E    +  + REV+ALK K+     T  +     G   V++     +E
Sbjct: 1904 NANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENADGSEE 1963



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 75/370 (20%), Positives = 155/370 (41%), Gaps = 43/370 (11%)

Query: 80   EGELQARDEVIGILKAE-KMDLALLEAQYGFVTPKKVLEALQRDAFQA--KSTPWQEDIY 136
            E +LQARDE     + + +  L   E +      ++ L A  +   +   K    Q D  
Sbjct: 1584 ERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSA 1643

Query: 137  EKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHK----EYMEKSDEF 192
             K   E  K + K +   +    +L  A  SR +     +E ++K K    + M+  ++ 
Sbjct: 1644 IKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDL 1703

Query: 193  ICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQ 252
                    ER +K  D E +   E+          L++E  +L++    + +E +     
Sbjct: 1704 AA-----AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGN 1758

Query: 253  LTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAK 312
            +     ++++ T  A++   +LA   +  Q+ E    +LE++ +   +K H+ +  + +K
Sbjct: 1759 MEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSK 1818

Query: 313  LTNEDSQNRQLQQKLAALSRQID----ELEETNRSLRKAEEELQDI-------------- 354
                 S    L+ K+A L  Q++    E +   +SL++ +++L++I              
Sbjct: 1819 F---KSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQY 1875

Query: 355  KEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFK 414
            KE+  KG        A V++L+++   +E  +EE  ++    R L + L+  T  ++   
Sbjct: 1876 KEQAEKGN-------ARVKQLKRQ---LEEAEEESQRINANRRKLQRELDEATESNEAMG 1925

Query: 415  LEVEKLSKRI 424
             EV  L  ++
Sbjct: 1926 REVNALKSKL 1935


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score =  146 bits (368), Expect = 1e-34
 Identities = 192/788 (24%), Positives = 345/788 (43%), Gaps = 137/788 (17%)

Query: 109  FVTPKKVLEAL-QRDAFQAKSTPWQE--DIYEKPMNELDKVVEKHKESYRRILGQLLVAE 165
            F   K +L+   Q +  QAK    Q+  +  +K  NEL ++ +KH +       + L+ E
Sbjct: 845  FTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEE---KNLLQE 901

Query: 166  KSRRQTILELEEEKR------KHKEYMEKSDEFICLLEQECER-------LKKLIDQEIK 212
            + + +T L  E E+       K +E  E   E    LE+E +R        KK+  Q + 
Sbjct: 902  QLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLD 961

Query: 213  SQEEKEQEKEKRVTTLKEELT------KLKSFALMVVDEQQRLTAQLTLQRQKIQELTTN 266
             +E+ E+E+  R     E++T      KL+   L++ D+  +L+ +  L  ++I +LTTN
Sbjct: 962  LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1021

Query: 267  AKETHTK--------------LALAEARVQEEEQKATRLEK---ELQTQTTKFHQDQDTI 309
              E   K              ++  E R+++EE+    LEK   +L+   + FH+    +
Sbjct: 1022 LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADL 1081

Query: 310  MAKLTNEDSQNRQLQQKL-AALSRQIDELEETNRSLRKAEE---ELQDIKEKI------- 358
             A++     Q  + +++L AAL+R  DE+ + N +L+K  E    + D++E +       
Sbjct: 1082 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR 1141

Query: 359  SKGEYGNAGIMAEVEELRKRV---LDMEGKDEEL-IKMEEQCRDLNKRLERETLQSKDFK 414
            +K E     +  E+E L+  +   LD     +EL  K E++   L K L+ ET +S + +
Sbjct: 1142 NKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEET-RSHEAQ 1200

Query: 415  LE---------VEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELE-- 463
            ++         VE+L++++   ++ +   +K+KQ       +L  E     Q  QE+E  
Sbjct: 1201 VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHK 1260

Query: 464  --SLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAA 521
               L+ +++EL++  S  E+    L + + KL+               K  K    + + 
Sbjct: 1261 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1320

Query: 522  SSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDL 581
            SSQLQ  Q       E L EET++    K +V  K+  + +ER+ L+++L  E E   +L
Sbjct: 1321 SSQLQDTQ-------ELLQEETRQ----KLNVSTKLRQLEEERNSLQDQLDEEMEAKQNL 1369

Query: 582  LSRVNML-------KNRLQ----SLEAIE---KDFLK--NKLNQDSGKSTTALHQENNKI 625
               ++ L       K +LQ    ++EA+E   K F K    L Q   +   A  +     
Sbjct: 1370 ERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK 1429

Query: 626  KELSQEVERLKLKLKDMKAIEDDLMKTEDEYETL-------ERRYANERDKAQFLSKELE 678
              L QE++ L + L + + +  +L K + +++ L         +YA+ERD+A+  ++E E
Sbjct: 1430 NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1489

Query: 679  HVKMELAKYKLAEKTETSHE-------------------QWLFKRLQEEEAKSGHLSREV 719
               + LA+  L E  E   E                     + K + E E     L  ++
Sbjct: 1490 TKALSLAR-ALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM 1548

Query: 720  DALKEKIH----EYMATEDLICHLQGDHSV--------LQKKLNQQENRNRDLGREIENL 767
            + +K ++     E  ATED    L+ +           LQ +  Q E + R L R++   
Sbjct: 1549 EEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEY 1608

Query: 768  TKELERYR 775
              ELE  R
Sbjct: 1609 ETELEDER 1616



 Score =  127 bits (319), Expect = 6e-29
 Identities = 157/696 (22%), Positives = 302/696 (43%), Gaps = 86/696 (12%)

Query: 137  EKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICLL 196
            EK   EL+K+  K +        Q+   +    +  ++L +++ + +  + + D+ I   
Sbjct: 1054 EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQK 1113

Query: 197  EQECERLKKL------IDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLT 250
                +++++L      + +++ S+     + EK+   L EEL  LK+    + D      
Sbjct: 1114 NNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKT---ELEDTLDSTA 1170

Query: 251  AQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIM 310
             Q  L+ ++ QE+T   K    +    EA+VQE  QK  +  +EL  Q  +F + +  + 
Sbjct: 1171 TQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD 1230

Query: 311  AKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMA 370
                  + +N  L  +L  L +   E+E      +K E ++Q+++ K S GE   A +  
Sbjct: 1231 KNKQTLEKENADLAGELRVLGQAKQEVEHKK---KKLEAQVQELQSKCSDGERARAELND 1287

Query: 371  EVEELRKRV-------LDMEGKDEELIK----MEEQCRDLNKRLERETLQ-----SKDFK 414
            +V +L+  V        + EGK  +L K    +  Q +D  + L+ ET Q     +K  +
Sbjct: 1288 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1347

Query: 415  LEVEKLSKRIMALEKLEDAFN-------------KSKQECYSLKCNLEKERMTTKQLSQE 461
            LE E+ S +    E++E   N              SK++       +E      K+  +E
Sbjct: 1348 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE 1407

Query: 462  LESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAA 521
            +E+L  + +E  A   +LEKT+  L+++L  L    V+ +D ++ +   L+K + K    
Sbjct: 1408 IENLTQQYEEKAAAYDKLEKTKNRLQQELDDL----VVDLDNQRQLVSNLEKKQRKF--- 1460

Query: 522  SSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDL 581
              QL  E+  +++   K  +E  RA     + E K  S+ +    L+  L+A+EE     
Sbjct: 1461 -DQLLAEEKNISS---KYADERDRAEAEAREKETKALSLARA---LEEALEAKEE----- 1508

Query: 582  LSRVN-MLKNRLQSLEAIEKDFLKN--KLNQDSGKSTTALHQENNKIKELSQEVE----- 633
            L R N MLK  ++ L + + D  KN  +L +      T + +   +++EL  E++     
Sbjct: 1509 LERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDA 1568

Query: 634  --RLKLKLKDMKA-IEDDLMKTEDEYETLERR-----------YANERDKAQFLSKELEH 679
              RL++ ++ +K   E DL   +++ E   R+             +ER +    +   + 
Sbjct: 1569 KLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKK 1628

Query: 680  VKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMAT----EDL 735
            ++ +L   +L   +     +   K+L++ +A+     RE++  +    E  AT    E  
Sbjct: 1629 LEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKK 1688

Query: 736  ICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKEL 771
               L+ D   LQ+ L   E   +    E E L +EL
Sbjct: 1689 AKSLEADLMQLQEDLAAAERARKQADLEKEELAEEL 1724



 Score =  119 bits (298), Expect = 2e-26
 Identities = 147/632 (23%), Positives = 280/632 (44%), Gaps = 61/632 (9%)

Query: 132  QEDIYEKPMNELD-----KVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYM 186
            QE + E+   +L+     + +E+ + S +  L + + A+++  + I  L  +    K+ +
Sbjct: 1328 QELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL 1387

Query: 187  EKSDEFICLLEQECERLKKLIDQEIKSQEEKE---QEKEKRVTTLKEELTKLKSFALMVV 243
            +     +  LE+  +R +K I+   +  EEK     + EK    L++EL  L    ++ +
Sbjct: 1388 QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL----VVDL 1443

Query: 244  DEQQRLTAQLTLQRQKIQELTTNAKETHTKLA----LAEARVQEEEQKATRLEKELQTQT 299
            D Q++L + L  +++K  +L    K   +K A     AEA  +E+E KA  L + L+   
Sbjct: 1444 DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL 1503

Query: 300  -TKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEE----LQDI 354
              K   ++   M K   ED     L      + + + ELE++ R+L    EE    L+++
Sbjct: 1504 EAKEELERTNKMLKAEMED-----LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1558

Query: 355  KEKISKGEYGNAGIMAEVEELRKRV-LDMEGKDEELIKMEEQCRDLNKRLERETLQSKDF 413
            ++++   E     +   ++ L+ +   D++ +DE+    EE+ R L ++L     + +D 
Sbjct: 1559 EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ---NEEKRRQLQRQLHEYETELEDE 1615

Query: 414  KLE-------VEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLK 466
            + +        +KL   +  LE   D+  K ++E       L K +   K   +ELE  +
Sbjct: 1616 RKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIK---QLRKLQAQMKDFQRELEDAR 1672

Query: 467  VRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASS--- 523
                E+ A     EK   +L+ DL +L+    +   ER      L+K E   + ASS   
Sbjct: 1673 ASRDEIFATAKENEKKAKSLEADLMQLQE--DLAAAERARKQADLEKEELAEELASSLSG 1730

Query: 524  --QLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEE------ 575
               LQ E+ ++     +L EE +    +   + +++   T++ + L N+L  E       
Sbjct: 1731 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 1790

Query: 576  EKGNDLLSRVNM-LKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVER 634
            E     L R N  L+++L  +E   K   K+ +     K      Q   + +E     + 
Sbjct: 1791 ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKS 1850

Query: 635  LKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTE 694
            LK K K +K I   L++ EDE +  E+ Y  + +K     K+L   K +L + +   +  
Sbjct: 1851 LKQKDKKLKEI---LLQVEDERKMAEQ-YKEQAEKGNARVKQL---KRQLEEAEEESQRI 1903

Query: 695  TSHEQWLFKRLQEEEAKSGHLSREVDALKEKI 726
             ++ + L + L E    +  + REV+ALK K+
Sbjct: 1904 NANRRKLQRELDEATESNEAMGREVNALKSKL 1935



 Score = 85.5 bits (210), Expect = 3e-16
 Identities = 114/542 (21%), Positives = 218/542 (40%), Gaps = 125/542 (23%)

Query: 136  YEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICL 195
            YE+     DK+ EK K   ++ L  L+V   ++RQ +  LE+++RK  +          L
Sbjct: 1415 YEEKAAAYDKL-EKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ----------L 1463

Query: 196  LEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTL 255
            L +E     K  D+  +++ E  +EKE +  +L   L +    AL   +E +R    L  
Sbjct: 1464 LAEEKNISSKYADERDRAEAEA-REKETKALSLARALEE----ALEAKEELERTNKMLKA 1518

Query: 256  QRQKI------------------QELTTNAKETHTKLALAEARVQEEEQKATRLEKELQT 297
            + + +                  + L T  +E  T+L   E  +Q  E    RLE  +Q 
Sbjct: 1519 EMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQA 1578

Query: 298  QTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDE--------------------- 336
               +F +D   + A+    + + RQLQ++L     ++++                     
Sbjct: 1579 LKGQFERD---LQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1635

Query: 337  -----------LEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGK 385
                        EE  + LRK + +++D + ++         I A  +E  K+   +E  
Sbjct: 1636 LELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEAD 1695

Query: 386  DEEL---------------IKMEEQCRDLNKRLE-RETLQSKDFKLEV------EKLSKR 423
              +L               ++ EE   +L   L  R  LQ +  +LE       E+L + 
Sbjct: 1696 LMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEE 1755

Query: 424  IMALEKLEDAFNKSKQECYSLKCNLEKERMTTK-------QLSQELESLKVRIKELE--- 473
               +E + D   K+ Q+   L   L  ER T +       QL ++ + L+ ++ E+E   
Sbjct: 1756 QGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAV 1815

Query: 474  ---------AIESRLEKTEF--------------TLKEDLTKLKTLTVMFVDERKTMSEK 510
                     A+E+++ + E               +LK+   KLK + +   DERK M+E+
Sbjct: 1816 KSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERK-MAEQ 1874

Query: 511  LKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNK 570
             K+  +K  A   QL+ +  +    ++++    ++  +   +  E   ++ +E + LK+K
Sbjct: 1875 YKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1934

Query: 571  LK 572
            L+
Sbjct: 1935 LR 1936



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 75/370 (20%), Positives = 155/370 (41%), Gaps = 43/370 (11%)

Query: 80   EGELQARDEVIGILKAE-KMDLALLEAQYGFVTPKKVLEALQRDAFQA--KSTPWQEDIY 136
            E +LQARDE     + + +  L   E +      ++ L A  +   +   K    Q D  
Sbjct: 1584 ERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSA 1643

Query: 137  EKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHK----EYMEKSDEF 192
             K   E  K + K +   +    +L  A  SR +     +E ++K K    + M+  ++ 
Sbjct: 1644 IKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDL 1703

Query: 193  ICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQ 252
                    ER +K  D E +   E+          L++E  +L++    + +E +     
Sbjct: 1704 AA-----AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGN 1758

Query: 253  LTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAK 312
            +     ++++ T  A++   +LA   +  Q+ E    +LE++ +   +K H+ +  + +K
Sbjct: 1759 MEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSK 1818

Query: 313  LTNEDSQNRQLQQKLAALSRQID----ELEETNRSLRKAEEELQDI-------------- 354
                 S    L+ K+A L  Q++    E +   +SL++ +++L++I              
Sbjct: 1819 F---KSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQY 1875

Query: 355  KEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFK 414
            KE+  KG        A V++L+++   +E  +EE  ++    R L + L+  T  ++   
Sbjct: 1876 KEQAEKGN-------ARVKQLKRQ---LEEAEEESQRINANRRKLQRELDEATESNEAMG 1925

Query: 415  LEVEKLSKRI 424
             EV  L  ++
Sbjct: 1926 REVNALKSKL 1935


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score =  146 bits (368), Expect = 1e-34
 Identities = 192/788 (24%), Positives = 345/788 (43%), Gaps = 137/788 (17%)

Query: 109  FVTPKKVLEAL-QRDAFQAKSTPWQE--DIYEKPMNELDKVVEKHKESYRRILGQLLVAE 165
            F   K +L+   Q +  QAK    Q+  +  +K  NEL ++ +KH +       + L+ E
Sbjct: 838  FTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEE---KNLLQE 894

Query: 166  KSRRQTILELEEEKR------KHKEYMEKSDEFICLLEQECER-------LKKLIDQEIK 212
            + + +T L  E E+       K +E  E   E    LE+E +R        KK+  Q + 
Sbjct: 895  QLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLD 954

Query: 213  SQEEKEQEKEKRVTTLKEELT------KLKSFALMVVDEQQRLTAQLTLQRQKIQELTTN 266
             +E+ E+E+  R     E++T      KL+   L++ D+  +L+ +  L  ++I +LTTN
Sbjct: 955  LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1014

Query: 267  AKETHTK--------------LALAEARVQEEEQKATRLEK---ELQTQTTKFHQDQDTI 309
              E   K              ++  E R+++EE+    LEK   +L+   + FH+    +
Sbjct: 1015 LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADL 1074

Query: 310  MAKLTNEDSQNRQLQQKL-AALSRQIDELEETNRSLRKAEE---ELQDIKEKI------- 358
             A++     Q  + +++L AAL+R  DE+ + N +L+K  E    + D++E +       
Sbjct: 1075 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR 1134

Query: 359  SKGEYGNAGIMAEVEELRKRV---LDMEGKDEEL-IKMEEQCRDLNKRLERETLQSKDFK 414
            +K E     +  E+E L+  +   LD     +EL  K E++   L K L+ ET +S + +
Sbjct: 1135 NKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEET-RSHEAQ 1193

Query: 415  LE---------VEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELE-- 463
            ++         VE+L++++   ++ +   +K+KQ       +L  E     Q  QE+E  
Sbjct: 1194 VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHK 1253

Query: 464  --SLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAA 521
               L+ +++EL++  S  E+    L + + KL+               K  K    + + 
Sbjct: 1254 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1313

Query: 522  SSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDL 581
            SSQLQ  Q       E L EET++    K +V  K+  + +ER+ L+++L  E E   +L
Sbjct: 1314 SSQLQDTQ-------ELLQEETRQ----KLNVSTKLRQLEEERNSLQDQLDEEMEAKQNL 1362

Query: 582  LSRVNML-------KNRLQ----SLEAIE---KDFLK--NKLNQDSGKSTTALHQENNKI 625
               ++ L       K +LQ    ++EA+E   K F K    L Q   +   A  +     
Sbjct: 1363 ERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK 1422

Query: 626  KELSQEVERLKLKLKDMKAIEDDLMKTEDEYETL-------ERRYANERDKAQFLSKELE 678
              L QE++ L + L + + +  +L K + +++ L         +YA+ERD+A+  ++E E
Sbjct: 1423 NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1482

Query: 679  HVKMELAKYKLAEKTETSHE-------------------QWLFKRLQEEEAKSGHLSREV 719
               + LA+  L E  E   E                     + K + E E     L  ++
Sbjct: 1483 TKALSLAR-ALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM 1541

Query: 720  DALKEKIH----EYMATEDLICHLQGDHSV--------LQKKLNQQENRNRDLGREIENL 767
            + +K ++     E  ATED    L+ +           LQ +  Q E + R L R++   
Sbjct: 1542 EEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEY 1601

Query: 768  TKELERYR 775
              ELE  R
Sbjct: 1602 ETELEDER 1609



 Score =  127 bits (319), Expect = 6e-29
 Identities = 157/696 (22%), Positives = 302/696 (43%), Gaps = 86/696 (12%)

Query: 137  EKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICLL 196
            EK   EL+K+  K +        Q+   +    +  ++L +++ + +  + + D+ I   
Sbjct: 1047 EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQK 1106

Query: 197  EQECERLKKL------IDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLT 250
                +++++L      + +++ S+     + EK+   L EEL  LK+    + D      
Sbjct: 1107 NNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKT---ELEDTLDSTA 1163

Query: 251  AQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIM 310
             Q  L+ ++ QE+T   K    +    EA+VQE  QK  +  +EL  Q  +F + +  + 
Sbjct: 1164 TQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD 1223

Query: 311  AKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMA 370
                  + +N  L  +L  L +   E+E      +K E ++Q+++ K S GE   A +  
Sbjct: 1224 KNKQTLEKENADLAGELRVLGQAKQEVEHKK---KKLEAQVQELQSKCSDGERARAELND 1280

Query: 371  EVEELRKRV-------LDMEGKDEELIK----MEEQCRDLNKRLERETLQ-----SKDFK 414
            +V +L+  V        + EGK  +L K    +  Q +D  + L+ ET Q     +K  +
Sbjct: 1281 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1340

Query: 415  LEVEKLSKRIMALEKLEDAFN-------------KSKQECYSLKCNLEKERMTTKQLSQE 461
            LE E+ S +    E++E   N              SK++       +E      K+  +E
Sbjct: 1341 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE 1400

Query: 462  LESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAA 521
            +E+L  + +E  A   +LEKT+  L+++L  L    V+ +D ++ +   L+K + K    
Sbjct: 1401 IENLTQQYEEKAAAYDKLEKTKNRLQQELDDL----VVDLDNQRQLVSNLEKKQRKF--- 1453

Query: 522  SSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDL 581
              QL  E+  +++   K  +E  RA     + E K  S+ +    L+  L+A+EE     
Sbjct: 1454 -DQLLAEEKNISS---KYADERDRAEAEAREKETKALSLARA---LEEALEAKEE----- 1501

Query: 582  LSRVN-MLKNRLQSLEAIEKDFLKN--KLNQDSGKSTTALHQENNKIKELSQEVE----- 633
            L R N MLK  ++ L + + D  KN  +L +      T + +   +++EL  E++     
Sbjct: 1502 LERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDA 1561

Query: 634  --RLKLKLKDMKA-IEDDLMKTEDEYETLERR-----------YANERDKAQFLSKELEH 679
              RL++ ++ +K   E DL   +++ E   R+             +ER +    +   + 
Sbjct: 1562 KLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKK 1621

Query: 680  VKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMAT----EDL 735
            ++ +L   +L   +     +   K+L++ +A+     RE++  +    E  AT    E  
Sbjct: 1622 LEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKK 1681

Query: 736  ICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKEL 771
               L+ D   LQ+ L   E   +    E E L +EL
Sbjct: 1682 AKSLEADLMQLQEDLAAAERARKQADLEKEELAEEL 1717



 Score =  119 bits (298), Expect = 2e-26
 Identities = 147/632 (23%), Positives = 280/632 (44%), Gaps = 61/632 (9%)

Query: 132  QEDIYEKPMNELD-----KVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYM 186
            QE + E+   +L+     + +E+ + S +  L + + A+++  + I  L  +    K+ +
Sbjct: 1321 QELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL 1380

Query: 187  EKSDEFICLLEQECERLKKLIDQEIKSQEEKE---QEKEKRVTTLKEELTKLKSFALMVV 243
            +     +  LE+  +R +K I+   +  EEK     + EK    L++EL  L    ++ +
Sbjct: 1381 QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL----VVDL 1436

Query: 244  DEQQRLTAQLTLQRQKIQELTTNAKETHTKLA----LAEARVQEEEQKATRLEKELQTQT 299
            D Q++L + L  +++K  +L    K   +K A     AEA  +E+E KA  L + L+   
Sbjct: 1437 DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL 1496

Query: 300  -TKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEE----LQDI 354
              K   ++   M K   ED     L      + + + ELE++ R+L    EE    L+++
Sbjct: 1497 EAKEELERTNKMLKAEMED-----LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1551

Query: 355  KEKISKGEYGNAGIMAEVEELRKRV-LDMEGKDEELIKMEEQCRDLNKRLERETLQSKDF 413
            ++++   E     +   ++ L+ +   D++ +DE+    EE+ R L ++L     + +D 
Sbjct: 1552 EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ---NEEKRRQLQRQLHEYETELEDE 1608

Query: 414  KLE-------VEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLK 466
            + +        +KL   +  LE   D+  K ++E       L K +   K   +ELE  +
Sbjct: 1609 RKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIK---QLRKLQAQMKDFQRELEDAR 1665

Query: 467  VRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASS--- 523
                E+ A     EK   +L+ DL +L+    +   ER      L+K E   + ASS   
Sbjct: 1666 ASRDEIFATAKENEKKAKSLEADLMQLQE--DLAAAERARKQADLEKEELAEELASSLSG 1723

Query: 524  --QLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEE------ 575
               LQ E+ ++     +L EE +    +   + +++   T++ + L N+L  E       
Sbjct: 1724 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 1783

Query: 576  EKGNDLLSRVNM-LKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVER 634
            E     L R N  L+++L  +E   K   K+ +     K      Q   + +E     + 
Sbjct: 1784 ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKS 1843

Query: 635  LKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTE 694
            LK K K +K I   L++ EDE +  E+ Y  + +K     K+L   K +L + +   +  
Sbjct: 1844 LKQKDKKLKEI---LLQVEDERKMAEQ-YKEQAEKGNARVKQL---KRQLEEAEEESQRI 1896

Query: 695  TSHEQWLFKRLQEEEAKSGHLSREVDALKEKI 726
             ++ + L + L E    +  + REV+ALK K+
Sbjct: 1897 NANRRKLQRELDEATESNEAMGREVNALKSKL 1928



 Score = 85.5 bits (210), Expect = 3e-16
 Identities = 114/542 (21%), Positives = 218/542 (40%), Gaps = 125/542 (23%)

Query: 136  YEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICL 195
            YE+     DK+ EK K   ++ L  L+V   ++RQ +  LE+++RK  +          L
Sbjct: 1408 YEEKAAAYDKL-EKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ----------L 1456

Query: 196  LEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTL 255
            L +E     K  D+  +++ E  +EKE +  +L   L +    AL   +E +R    L  
Sbjct: 1457 LAEEKNISSKYADERDRAEAEA-REKETKALSLARALEE----ALEAKEELERTNKMLKA 1511

Query: 256  QRQKI------------------QELTTNAKETHTKLALAEARVQEEEQKATRLEKELQT 297
            + + +                  + L T  +E  T+L   E  +Q  E    RLE  +Q 
Sbjct: 1512 EMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQA 1571

Query: 298  QTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDE--------------------- 336
               +F +D   + A+    + + RQLQ++L     ++++                     
Sbjct: 1572 LKGQFERD---LQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1628

Query: 337  -----------LEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGK 385
                        EE  + LRK + +++D + ++         I A  +E  K+   +E  
Sbjct: 1629 LELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEAD 1688

Query: 386  DEEL---------------IKMEEQCRDLNKRLE-RETLQSKDFKLEV------EKLSKR 423
              +L               ++ EE   +L   L  R  LQ +  +LE       E+L + 
Sbjct: 1689 LMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEE 1748

Query: 424  IMALEKLEDAFNKSKQECYSLKCNLEKERMTTK-------QLSQELESLKVRIKELE--- 473
               +E + D   K+ Q+   L   L  ER T +       QL ++ + L+ ++ E+E   
Sbjct: 1749 QGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAV 1808

Query: 474  ---------AIESRLEKTEF--------------TLKEDLTKLKTLTVMFVDERKTMSEK 510
                     A+E+++ + E               +LK+   KLK + +   DERK M+E+
Sbjct: 1809 KSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERK-MAEQ 1867

Query: 511  LKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNK 570
             K+  +K  A   QL+ +  +    ++++    ++  +   +  E   ++ +E + LK+K
Sbjct: 1868 YKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1927

Query: 571  LK 572
            L+
Sbjct: 1928 LR 1929



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 75/370 (20%), Positives = 155/370 (41%), Gaps = 43/370 (11%)

Query: 80   EGELQARDEVIGILKAE-KMDLALLEAQYGFVTPKKVLEALQRDAFQA--KSTPWQEDIY 136
            E +LQARDE     + + +  L   E +      ++ L A  +   +   K    Q D  
Sbjct: 1577 ERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSA 1636

Query: 137  EKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHK----EYMEKSDEF 192
             K   E  K + K +   +    +L  A  SR +     +E ++K K    + M+  ++ 
Sbjct: 1637 IKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDL 1696

Query: 193  ICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQ 252
                    ER +K  D E +   E+          L++E  +L++    + +E +     
Sbjct: 1697 AA-----AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGN 1751

Query: 253  LTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAK 312
            +     ++++ T  A++   +LA   +  Q+ E    +LE++ +   +K H+ +  + +K
Sbjct: 1752 MEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSK 1811

Query: 313  LTNEDSQNRQLQQKLAALSRQID----ELEETNRSLRKAEEELQDI-------------- 354
                 S    L+ K+A L  Q++    E +   +SL++ +++L++I              
Sbjct: 1812 F---KSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQY 1868

Query: 355  KEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFK 414
            KE+  KG        A V++L+++   +E  +EE  ++    R L + L+  T  ++   
Sbjct: 1869 KEQAEKGN-------ARVKQLKRQ---LEEAEEESQRINANRRKLQRELDEATESNEAMG 1918

Query: 415  LEVEKLSKRI 424
             EV  L  ++
Sbjct: 1919 REVNALKSKL 1928


>gi|24308179 CTTNBP2 N-terminal like [Homo sapiens]
          Length = 639

 Score =  145 bits (366), Expect = 2e-34
 Identities = 90/299 (30%), Positives = 174/299 (58%), Gaps = 5/299 (1%)

Query: 65  EDLSRDDLLFLLSILEGELQARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQRD-- 122
           E LS+ +LL L SILEGEL+ARD VI  LKA+  D   +E +YG       L ALQRD  
Sbjct: 4   EKLSKPELLTLFSILEGELEARDLVIEALKAQHRD-TFIEERYGKYNISDPLMALQRDFE 62

Query: 123 AFQAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKH 182
             + K+   ++ +   P++ L  V+++ K    R+L QL  AE   R+ IL+LEEE+++H
Sbjct: 63  TLKEKNDGEKQPVCTNPLSILKVVMKQCKNMQERMLSQLAAAESRHRKVILDLEEERQRH 122

Query: 183 KEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMV 242
            +   + D+   +LE+E ERL + ++ E    ++ E+E++K  + L+EE ++ K  + M+
Sbjct: 123 AQDTAEGDDVTYMLEKERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEERSRHKQLSSML 182

Query: 243 VDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKF 302
           V E ++ T +   + QK  EL+   ++  ++++  E  +  E ++  + E +++ Q ++F
Sbjct: 183 VLECKKATNKAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEF 242

Query: 303 HQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKG 361
             +++ + AKL  E+++ + L++++ +L + + +LE +++     E+  + +   +SKG
Sbjct: 243 DIEREQLRAKLNREENRTKTLKEEMESLKKIVKDLEASHQHSSPNEQLKKPV--TVSKG 299



 Score = 76.3 bits (186), Expect = 2e-13
 Identities = 61/230 (26%), Positives = 115/230 (50%), Gaps = 17/230 (7%)

Query: 394 EQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERM 453
           +QC+++ +R+  +   ++       +  K I+ LE+      +   E   +   LEKER 
Sbjct: 88  KQCKNMQERMLSQLAAAES------RHRKVILDLEEERQRHAQDTAEGDDVTYMLEKER- 140

Query: 454 TTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKK 513
             ++L+Q+LE  K ++K+ E  + +L      L+E+ ++ K L+ M V E K  + K  +
Sbjct: 141 --ERLTQQLEFEKSQVKKFEKEQKKLSSQ---LEEERSRHKQLSSMLVLECKKATNKAAE 195

Query: 514 TEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKA 573
              K    S +L+ E+++V+ + E+L  E KR L+++  VE+++     ER+ L+ KL  
Sbjct: 196 EGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNR 255

Query: 574 EEEKGNDLLSRVNMLKNRLQSLEAIEK-----DFLKNKLNQDSGKSTTAL 618
           EE +   L   +  LK  ++ LEA  +     + LK  +    G +T  L
Sbjct: 256 EENRTKTLKEEMESLKKIVKDLEASHQHSSPNEQLKKPVTVSKGTATEPL 305



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 71/319 (22%), Positives = 143/319 (44%), Gaps = 22/319 (6%)

Query: 488 EDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKL--IEETKR 545
           E L+K + LT+  + E +  +  L     K Q   + ++    K   +++ L  ++    
Sbjct: 4   EKLSKPELLTLFSILEGELEARDLVIEALKAQHRDTFIEERYGKYN-ISDPLMALQRDFE 62

Query: 546 ALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKN 605
            LK K D  EK    T     LK  +K  +     +LS++   ++R + +  ++ +  + 
Sbjct: 63  TLKEKND-GEKQPVCTNPLSILKVVMKQCKNMQERMLSQLAAAESRHRKV-ILDLEEERQ 120

Query: 606 KLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYAN 665
           +  QD+ +     +    + + L+Q++E  K ++K          K E E + L  +   
Sbjct: 121 RHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQVK----------KFEKEQKKLSSQLEE 170

Query: 666 ERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEK 725
           ER + + LS  L  ++ + A  K AE+ + + E  L  +L++E+++   L  E+ A +++
Sbjct: 171 ERSRHKQLSSMLV-LECKKATNKAAEEGQKAGE--LSLKLEKEKSRVSKLEEELAAERKR 227

Query: 726 -IHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPS 784
            +      E  +     +   L+ KLN++ENR + L  E+E+L K +   +    S + S
Sbjct: 228 GLQTEAQVEKQLSEFDIEREQLRAKLNREENRTKTLKEEMESLKKIV---KDLEASHQHS 284

Query: 785 LNGRRISDPQVFSKEVQTE 803
               ++  P   SK   TE
Sbjct: 285 SPNEQLKKPVTVSKGTATE 303


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score =  134 bits (336), Expect = 6e-31
 Identities = 172/782 (21%), Positives = 349/782 (44%), Gaps = 109/782 (13%)

Query: 80   EGELQARDEVIGILKAE--KMDLALLEAQYGFVTPKKVLEALQRDAFQAKSTPWQEDIYE 137
            E ELQA+DE +  +K +  K++  L E +      +K  + L+     A+    + +++ 
Sbjct: 851  EEELQAKDEELLKVKEKQTKVEGELEEME------RKHQQLLEEKNILAEQLQAETELFA 904

Query: 138  KPMNELDKVVEKHKESYRRILGQL--LVAEKSRRQTILELEEEKRKHKEYMEKSDEFICL 195
            +      ++  K K+    IL  L   V E+  R  IL+   EK+K + +++  +E +  
Sbjct: 905  EAEEMRARLAAK-KQELEEILHDLESRVEEEEERNQILQ--NEKKKMQAHIQDLEEQL-- 959

Query: 196  LEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTL 255
               E E  ++ +  E  + E K ++ E+ +  L+++ +K      ++ D     ++QL  
Sbjct: 960  --DEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAE 1017

Query: 256  QRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEK---ELQTQTTKFHQDQDTIMAK 312
            + +K + L     +    ++  E R+++EE+    LEK   +L  +TT        + A+
Sbjct: 1018 EEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQ 1077

Query: 313  LTNEDSQNRQLQQKL-AALSRQIDELEETNRSLR----------KAEEELQDIKEKISKG 361
            +     Q  + +++L  AL+R  DE    N +L+          + +E+ +  K   +K 
Sbjct: 1078 IDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKA 1137

Query: 362  EYGNAGIMAEVEELRKRV---LDMEGKDEEL-IKMEEQCRDLNKRLERETLQSKDFKLEV 417
            E     +  E+E L+  +   LD     +EL  K E++  +L K LE ET   K+ + ++
Sbjct: 1138 EKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEET---KNHEAQI 1194

Query: 418  EKLSKR-IMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIE 476
            + + +R   ALE+L +   ++K+     K NLEK +   + L  + + L   +K L+ ++
Sbjct: 1195 QDMRQRHATALEELSEQLEQAKR----FKANLEKNK---QGLETDNKELACEVKVLQQVK 1247

Query: 477  SRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQ------VEQN 530
            +  E     L   + +L          R  ++EK  K +++L   S+ L+      ++  
Sbjct: 1248 AESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFA 1307

Query: 531  KVTTVTEKLIEETKRALKSKT----DVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVN 586
            K     E  +++T+  L+ +T    ++  ++  + +E++ L+ + + EEE   +L  +V 
Sbjct: 1308 KDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVL 1367

Query: 587  MLKNRL--------------QSLEAIEKDFLKN--KLNQDSGKSTTALHQENNKIKELSQ 630
             L+++L              +SLE  +K  LK+   L+Q   +   A  +       L Q
Sbjct: 1368 ALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQ 1427

Query: 631  EVERLKLKLKDMKAIEDDLMKTEDEYE-------TLERRYANERDKAQFLSKELEHVKME 683
            E++ L + L   + +  +L K + +++       ++  RYA ERD+A+  ++E E   + 
Sbjct: 1428 ELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALS 1487

Query: 684  LAK-----YKLAEKTETSHEQW-------------LFKRLQEEEAKSGHLSREVDALKEK 725
            LA+      +  E+ E  ++Q              + K + E E     L ++V+ ++ +
Sbjct: 1488 LARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQ 1547

Query: 726  IH----EYMATEDLICHLQGDHSV--------LQKKLNQQENRNRDLGREIENLTKELER 773
            +     E  ATED    L+ +           LQ +  Q E + R L +++  L  ELE 
Sbjct: 1548 LEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELED 1607

Query: 774  YR 775
             R
Sbjct: 1608 ER 1609



 Score =  130 bits (327), Expect = 7e-30
 Identities = 185/837 (22%), Positives = 362/837 (43%), Gaps = 110/837 (13%)

Query: 65   EDLSRDDLLFLLSILEGELQARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQRDAF 124
            E+ +R +L      L+GE     + I  L+A+  +L L  A        K  E LQ    
Sbjct: 1046 EEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLA--------KKEEELQGALA 1097

Query: 125  QAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKE 184
            +       ++   K + EL   + + +E +         AEK +R    ELE  K + ++
Sbjct: 1098 RGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELED 1157

Query: 185  YMEKS---DEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTT----LKEELTKLKS 237
             ++ +    E     EQE   LKK +++E K+ E + Q+  +R  T    L E+L + K 
Sbjct: 1158 TLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKR 1217

Query: 238  FALMVVDEQQ-------RLTAQLTLQRQ-------KIQELTTNAKETHTKLALAEARVQE 283
            F   +   +Q        L  ++ + +Q       K ++L    +E H K++  +    E
Sbjct: 1218 FKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVE 1277

Query: 284  EEQKATRLEKELQTQTT----------KFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQ 333
              +KA++L+ EL   +T          KF +D  ++ ++L +     ++  ++   LS +
Sbjct: 1278 LAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSR 1337

Query: 334  IDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKME 393
            I +LEE   SL++ +EE ++ ++ + K          +V  L+ ++ D + K ++ +   
Sbjct: 1338 IRQLEEEKNSLQEQQEEEEEARKNLEK----------QVLALQSQLADTKKKVDDDLGTI 1387

Query: 394  EQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERM 453
            E   +  K+L       KD +   ++L ++ +A +KLE   N+ +QE   L  +L+ +R 
Sbjct: 1388 ESLEEAKKKL------LKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQ 1441

Query: 454  TTKQLSQELESLKVRIKELEAIESRL----EKTEFTLKEDLTKLKTLTVMFVDERKTMSE 509
                L ++ +     + E ++I +R     ++ E   +E  TK  +L        + + E
Sbjct: 1442 VASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLA-------RALEE 1494

Query: 510  KLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKN 569
             L+  E+  +  + QL+ +   + +  + + +      KSK  +E+++  +  + ++L++
Sbjct: 1495 ALEAKEE-FERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELED 1553

Query: 570  KLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELS 629
            +L+A E+    L   VNM     Q+++A  +  L+ +  Q+  K    + Q      EL 
Sbjct: 1554 ELQATEDA--KLRLEVNM-----QAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELE 1606

Query: 630  QEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMEL----- 684
             E ++  L +   K +E DL   E + E   +       + + L  +++  + EL     
Sbjct: 1607 DERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARA 1666

Query: 685  ------AKYKLAEKTETSHEQWLFKRLQEEEAKS----GHLSREVDALKEKI-------- 726
                  A+ K +EK   S E  +  +LQEE A S     H  +E D L ++I        
Sbjct: 1667 SRDEIFAQSKESEKKLKSLEAEIL-QLQEELASSERARRHAEQERDELADEITNSASGKS 1725

Query: 727  ---HEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRP 783
                E    E  I  L+ +    Q  +    +R R    +++ L  EL   R    + + 
Sbjct: 1726 ALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAER---SAAQK 1782

Query: 784  SLNGRRISDPQVFSKEVQTEAVDNE---PPDYKSLIPLERAVINGQLYEESENQDED 837
            S N R+  + Q  +KE++ +  + E      +K+ I    A I GQL E+ E + ++
Sbjct: 1783 SDNARQQLERQ--NKELKAKLQELEGAVKSKFKATISALEAKI-GQLEEQLEQEAKE 1836



 Score =  116 bits (290), Expect = 1e-25
 Identities = 137/692 (19%), Positives = 308/692 (44%), Gaps = 74/692 (10%)

Query: 160  QLLVAEKSRRQT-----ILELEEEKRKHKEYMEKSDEF-------ICLLEQECERLKKLI 207
            Q L+ E++R++      I +LEEEK   +E  E+ +E        +  L+ +    KK +
Sbjct: 1321 QELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKV 1380

Query: 208  DQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNA 267
            D ++ + E  E+ K+K +   +    +L+  AL   D+ ++   +L   +Q++ +LT + 
Sbjct: 1381 DDDLGTIESLEEAKKKLLKDAEALSQRLEEKAL-AYDKLEKTKNRL---QQELDDLTVDL 1436

Query: 268  KETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKL 327
                       + ++++++K  +L  E ++ + ++ +++D   A+   ++++   L + L
Sbjct: 1437 DHQRQ----VASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARAL 1492

Query: 328  AALSRQIDELEETNRSLRKAEEELQDIKEKISKG----EYGNAGIMAEVEELRKRVLDME 383
                   +E E  N+ LR   E+L   K+ + K     E     +  +VEE+R ++ ++E
Sbjct: 1493 EEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELE 1552

Query: 384  GK----DEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQ 439
             +    ++  +++E   + +  + ER+ LQ++D   E  +  KR++  +  E        
Sbjct: 1553 DELQATEDAKLRLEVNMQAMKAQFERD-LQTRD---EQNEEKKRLLIKQVRE-------- 1600

Query: 440  ECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVM 499
                L+  LE ER   KQ +  + S K    +L+ +E+++E       E + +L+ L   
Sbjct: 1601 ----LEAELEDER---KQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQ 1653

Query: 500  FVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYS 559
              D ++ + E+ + + D++ A S + + +   +     +L EE   + +++   E++   
Sbjct: 1654 MKDYQREL-EEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDE 1712

Query: 560  VTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQ----SLEAIEKDFLK-----NKLNQD 610
            +  E  +  +   A  ++   L +R+  L+  L+    ++E +   F K     + LN +
Sbjct: 1713 LADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAE 1772

Query: 611  SGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKT-----EDEYETLERRYAN 665
                 +A  + +N  ++L ++ + LK KL++++       K      E +   LE +   
Sbjct: 1773 LAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQ 1832

Query: 666  ERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEK 725
            E  +    +K +   + +L +  +  + E  H     +++++  A+   L R+++  +E+
Sbjct: 1833 EAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEE 1892

Query: 726  IHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPSL 785
                 A+             LQ++L+     N  L RE+  L   L R    S S   S 
Sbjct: 1893 ATRANASR----------RKLQRELDDATEANEGLSREVSTLKNRLRRGGPISFS--SSR 1940

Query: 786  NGRRISDPQVFSKEVQTEAVDNEPPDYKSLIP 817
            +GRR    +  S E+  +  +++  D     P
Sbjct: 1941 SGRRQLHLEGASLELSDDDTESKTSDVNETQP 1972



 Score =  110 bits (276), Expect = 6e-24
 Identities = 131/615 (21%), Positives = 275/615 (44%), Gaps = 57/615 (9%)

Query: 210  EIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQ---ELTTN 266
            ++  QEE+ Q K++ +  +KE+ TK++     +  + Q+L  +  +  +++Q   EL   
Sbjct: 846  QVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAE 905

Query: 267  AKETHTKLAL-----------AEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTN 315
            A+E   +LA             E+RV+EEE++     + LQ +  K       +  +L  
Sbjct: 906  AEEMRARLAAKKQELEEILHDLESRVEEEEER----NQILQNEKKKMQAHIQDLEEQLDE 961

Query: 316  EDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEEL 375
            E+   ++LQ +      +I ++EE    L     +    K+ +       +  +AE EE 
Sbjct: 962  EEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEK 1021

Query: 376  RKRVLDMEGKD-------EELIKMEEQCR-DLNKRLERETLQSKDFKLEVEKLSKRIMAL 427
             K +  +  K        EE +K EE+ R +L K   +   ++ D + ++ +L  +I   
Sbjct: 1022 AKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQI--- 1078

Query: 428  EKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELE-------AIESRLE 480
            ++L+    K ++E        + E +      + +  L+ +I EL+       A  ++ E
Sbjct: 1079 DELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAE 1138

Query: 481  KTEFTLKEDLTKLKTL------TVMFVDERKTMSE----KLKKT-EDKLQAASSQLQVEQ 529
            K +  L E+L  LKT       T     E +T  E    +LKK  E++ +   +Q+Q  +
Sbjct: 1139 KQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMR 1198

Query: 530  NKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLK 589
             +  T  E+L E+ ++A + K ++E+    +  +  +L  ++K  ++   +   +   L 
Sbjct: 1199 QRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLD 1258

Query: 590  NRLQSLEA--IEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKL-KDMKAIE 646
             ++Q L A   E D L+ +L + + K    L  E + +  L +E E+  +K  KD  ++E
Sbjct: 1259 AQVQELHAKVSEGDRLRVELAEKASK----LQNELDNVSTLLEEAEKKGIKFAKDAASLE 1314

Query: 647  DDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQ 706
              L  T++  +   R+  N   + + L +E   ++ +  + + A K        L  +L 
Sbjct: 1315 SQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLA 1374

Query: 707  EEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIEN 766
            + + K       +++L+E   + +   + +     + ++   KL + +NR   L +E+++
Sbjct: 1375 DTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNR---LQQELDD 1431

Query: 767  LTKELERYRHFSKSL 781
            LT +L+  R  + +L
Sbjct: 1432 LTVDLDHQRQVASNL 1446



 Score =  108 bits (270), Expect = 3e-23
 Identities = 112/526 (21%), Positives = 237/526 (45%), Gaps = 65/526 (12%)

Query: 82   ELQARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQRDAFQAKSTPWQEDIYEKPMN 141
            +L A ++ I    AE+ D A  EA+        +  AL+ +A +AK        +E+   
Sbjct: 1455 QLLAEEKSISARYAEERDRAEAEAREKETKALSLARALE-EALEAKEE------FERQNK 1507

Query: 142  ELDKVVEKHKESYRRILGQLLVAEKSRR---QTILELEEEKRKHKEYMEKSDEFICLLEQ 198
            +L   +E    S   +   +   EKS+R   Q + E+  +  + ++ ++ +++    LE 
Sbjct: 1508 QLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEV 1567

Query: 199  ECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQ 258
              + +K   ++++++++E+ +EK++                 +++ + + L A+L  +R+
Sbjct: 1568 NMQAMKAQFERDLQTRDEQNEEKKR-----------------LLIKQVRELEAELEDERK 1610

Query: 259  KIQELTTNAKETHTKLALAEARVQEEEQKATRLEKEL---QTQTTKFHQDQDTIMAKLTN 315
            +      + K+    L   EA+++   +    + K+L   Q Q   + ++ +   A    
Sbjct: 1611 QRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDE 1670

Query: 316  EDSQNRQLQQKLAALSRQI----DELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAE 371
              +Q+++ ++KL +L  +I    +EL  + R+ R AE+E  ++ ++I+    G + ++ E
Sbjct: 1671 IFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDE 1730

Query: 372  VEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLE 431
               L  R+  +E   EEL + +     LN R  + TLQ      E   L+    A +K +
Sbjct: 1731 KRRLEARIAQLE---EELEEEQSNMELLNDRFRKTTLQVDTLNAE---LAAERSAAQKSD 1784

Query: 432  DAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELE-AIESRLEKTEFTLKEDL 490
            +A                      +QL ++ + LK +++ELE A++S+ + T   L+  +
Sbjct: 1785 NA---------------------RQQLERQNKELKAKLQELEGAVKSKFKATISALEAKI 1823

Query: 491  TKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSK 550
             +L+        ER   ++ +++TE KL+    Q++ E+       E++ +   R  + K
Sbjct: 1824 GQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLK 1883

Query: 551  TDVEEKMYSVTK---ERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQ 593
              +EE     T+    R  L+ +L    E    L   V+ LKNRL+
Sbjct: 1884 RQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLR 1929



 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 117/571 (20%), Positives = 245/571 (42%), Gaps = 74/571 (12%)

Query: 310  MAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIM 369
            + ++T ++ + +   ++L  +  +  ++E     + +  ++L + K  +++       + 
Sbjct: 844  LLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELF 903

Query: 370  AEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEK 429
            AE EE+R R   +  K +EL   EE   DL  R+E E  +++  + E +K+   I  LE+
Sbjct: 904  AEAEEMRAR---LAAKKQEL---EEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEE 957

Query: 430  LEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVR------IKELEAIESRLEKTE 483
              D    ++Q     K  LEK     K    E E L +       IKE + +E R+ +  
Sbjct: 958  QLDEEEGARQ-----KLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECS 1012

Query: 484  FTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEET 543
              L E+  K K L                K  +K +   S L+ E+ K    T + +E+ 
Sbjct: 1013 SQLAEEEEKAKNLA---------------KIRNKQEVMISDLE-ERLKKEEKTRQELEKA 1056

Query: 544  KRALKSK-TDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVN----MLKNRLQSLEAI 598
            KR L  + TD+++++  +  + D+LK +L  +EE+    L+R +       N L+ +  +
Sbjct: 1057 KRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVREL 1116

Query: 599  EKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKD----------------- 641
            +      +L +D      + ++   + ++LS+E+E LK +L+D                 
Sbjct: 1117 QAQIA--ELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQ 1174

Query: 642  -----MKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETS 696
                  KA+E++    E + + + +R+A   ++     ++ +  K  L K K   +T+  
Sbjct: 1175 EVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNK 1234

Query: 697  HEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLI--------CHLQGDHSVLQK 748
                  K LQ+ +A+S H  +++DA  +++H  ++  D +          LQ +   +  
Sbjct: 1235 ELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVST 1294

Query: 749  KLNQQENRNRDLGREIENLTKELERYRH-FSKSLRPSLN-GRRISDPQVFSKEVQTEAVD 806
             L + E +     ++  +L  +L+  +    +  R  LN   RI   +     +Q +  +
Sbjct: 1295 LLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEE 1354

Query: 807  NEPPDYKSLIPLERAVINGQLYEESENQDED 837
             E  + +  +  +   +  QL +  +  D+D
Sbjct: 1355 EE--EARKNLEKQVLALQSQLADTKKKVDDD 1383



 Score = 65.1 bits (157), Expect = 4e-10
 Identities = 80/336 (23%), Positives = 141/336 (41%), Gaps = 47/336 (13%)

Query: 79   LEGELQARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQRDAFQAKSTPWQEDIYEK 138
            LE E + R   +   K  ++DL  LEAQ       +     Q    QA+   +Q ++ E 
Sbjct: 1605 LEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEA 1664

Query: 139  PMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICLLEQ 198
              +  D++  + KES +++  + L AE  + Q  L   E  R+H E  ++ DE    +  
Sbjct: 1665 RASR-DEIFAQSKESEKKL--KSLEAEILQLQEELASSERARRHAE--QERDELADEITN 1719

Query: 199  ECERLKKLIDQEIK-----SQEEKEQEKEK---------------RVTTLKEELTKLKSF 238
                   L+D++ +     +Q E+E E+E+               +V TL  EL   +S 
Sbjct: 1720 SASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSA 1779

Query: 239  ALMVVDEQQRLTAQLTLQRQKIQELTTNAKET--------HTKLALAEARVQEEEQKATR 290
            A    + +Q+L  Q    + K+QEL    K            K+   E ++++E ++   
Sbjct: 1780 AQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAA 1839

Query: 291  LEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQ---KLAALSRQIDELEE----TNRS 343
              K ++    K  +    +  +  + D    Q+++   ++  L RQ++E EE     N S
Sbjct: 1840 ANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANAS 1899

Query: 344  LRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRV 379
             RK + EL D  E        N G+  EV  L+ R+
Sbjct: 1900 RRKLQRELDDATE-------ANEGLSREVSTLKNRL 1928


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score =  132 bits (332), Expect = 2e-30
 Identities = 185/778 (23%), Positives = 325/778 (41%), Gaps = 152/778 (19%)

Query: 132  QEDIYEKPMNELDKVVEKHKESYRRI-----LGQLLVAEKSRRQTILELEEE-------- 178
            QE+       EL KV EK   +  R+     L   L+AEK + Q  L+ E E        
Sbjct: 843  QEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEEL 902

Query: 179  ----KRKHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQ----------EEKEQEKEK- 223
                  K +E  E   +    +E+E ER + L  ++ K Q          EE+E  ++K 
Sbjct: 903  RARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKL 962

Query: 224  ---RVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEAR 280
               +VTT + +L KL+   +++ D+  +L  +  L   +I E TTN  E   K       
Sbjct: 963  QLEKVTT-EAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKL 1021

Query: 281  VQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEET 340
              + E   T LE+ L+ +  K  Q+ +    KL   +  +  L  ++A L  QI EL+  
Sbjct: 1022 KNKHEAMITDLEERLRRE-EKQRQELEKTRRKL---EGDSTDLSDQIAELQAQIAELK-- 1075

Query: 341  NRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVL----DMEGKDEELIKMEEQC 396
               L K EEELQ    ++ +        + ++ EL  ++     D+E +     K E+Q 
Sbjct: 1076 -MQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQK 1134

Query: 397  RDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMT-- 454
            RDL + LE         K E+E       A ++L    +K +QE   LK  LE+E  T  
Sbjct: 1135 RDLGEELEA-------LKTELEDTLDSTAAQQELR---SKREQEVNILKKTLEEEAKTHE 1184

Query: 455  ------TKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMS 508
                   ++ SQ +E L  ++++ + +++ LEK + TL+ +  +L     + +  +    
Sbjct: 1185 AQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSE 1244

Query: 509  EKLKKTEDKLQAAS-----------------SQLQVEQNKVT-----------------T 534
             K KK E +LQ                    ++LQVE + VT                 +
Sbjct: 1245 HKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFS 1304

Query: 535  VTEKLIEETKRAL----KSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRV----- 585
              E  +++T+  L    + K  +  K+  V  E++  + +L+ EEE  ++L  ++     
Sbjct: 1305 ALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHA 1364

Query: 586  ---NMLKNRLQSLEAIE-KDFLKNKLNQD------SGKSTTALHQENNKIK-ELSQEVER 634
               +M K    S+  +E  + +K KL +D        +   A + +  K K  L QE++ 
Sbjct: 1365 QVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDD 1424

Query: 635  LKLKLKDMKAIEDDLMKTEDEYE-------TLERRYANERDKAQFLSKELEHVKMELAK- 686
            L + L   +    +L K + +++       T+  +YA ERD+A+  ++E E   + LA+ 
Sbjct: 1425 LLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARA 1484

Query: 687  -----------YKLAEKTETSHEQWLF------KRLQEEEAKSGHLSREVDALKEKIH-- 727
                        +L ++  T  E  +       K + E E     L ++V+ +K ++   
Sbjct: 1485 LEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEEL 1544

Query: 728  --EYMATEDLICHLQGDHSV--------LQKKLNQQENRNRDLGREIENLTKELERYR 775
              E  ATED    L+ +           LQ +  Q E + + L R++  +  ELE  R
Sbjct: 1545 EDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDER 1602



 Score =  128 bits (322), Expect = 3e-29
 Identities = 163/777 (20%), Positives = 330/777 (42%), Gaps = 98/777 (12%)

Query: 65   EDLSRDDLLFLLSILEGELQARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQRDAF 124
            E+  R +L      LEG+     + I  L+A+  +L +  A        K  E LQ    
Sbjct: 1039 EEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLA--------KKEEELQAALA 1090

Query: 125  QAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKE 184
            + +    Q+++  K + EL+  + + +E           AEK +R    ELE  K + ++
Sbjct: 1091 RVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELED 1150

Query: 185  YMEKS---DEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKR----VTTLKEELTKLKS 237
             ++ +    E     EQE   LKK +++E K+ E + QE  ++    V  L E+L + K 
Sbjct: 1151 TLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKR 1210

Query: 238  FALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEE------------ 285
                +   +Q L  +      +++ L     ++  K    EA++QE +            
Sbjct: 1211 VKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTE 1270

Query: 286  --QKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDE----LEE 339
               K T+L+ EL           D +   L+  DS++ +L +  +AL  Q+ +    L+E
Sbjct: 1271 LADKVTKLQVEL-----------DNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQE 1319

Query: 340  TNR-------SLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKM 392
             NR        L++ E+E    +E++ + E     +  ++  L  +V DM+ K E+ +  
Sbjct: 1320 ENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGC 1379

Query: 393  EEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSL-------- 444
             E   ++ ++L+      KD +   ++  +++ A +KLE    + +QE   L        
Sbjct: 1380 LETAEEVKRKLQ------KDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQR 1433

Query: 445  --KCNLEKERMTTKQLSQELESL-------------KVRIKELEAIE-SRLEKTEFTLKE 488
               CNLEK++    QL  E +++             + R KE +A+  +R  +     K 
Sbjct: 1434 QSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKA 1493

Query: 489  DLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALK 548
            +L +L       +++  +  + + K+  +L+ +   L+ +  ++ T  E+L +E +    
Sbjct: 1494 ELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATED 1553

Query: 549  SKTDVEEKMYSVTKERD-DLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDF---LK 604
            +K  +E  + ++  + + DL+ + +  EEK   L+ +V  ++  L+  E  ++      +
Sbjct: 1554 AKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELED-ERKQRSMAVAAR 1612

Query: 605  NKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKD-MKAIEDDLMKTEDEYETLERRY 663
             KL  D       +   N    E  +++ +L+ ++KD M+ ++D     E   E L +  
Sbjct: 1613 KKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASRE---EILAQAK 1669

Query: 664  ANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSG-------HLS 716
             NE+ K + +  E+  ++ ELA  + A++        L   +     K          L 
Sbjct: 1670 ENEK-KLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLE 1728

Query: 717  REVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELER 773
              +  L+E++ E     +LI       ++   ++N   N  R   ++ EN  ++LER
Sbjct: 1729 ARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLER 1785



 Score =  127 bits (318), Expect = 8e-29
 Identities = 151/652 (23%), Positives = 284/652 (43%), Gaps = 83/652 (12%)

Query: 123  AFQAKSTPWQEDIYEKPMNELD-----KVVEKHKESYRRILGQLLVAEKSRRQTILELEE 177
            A +++    QE + E+   +L      K VE  K S+R  L +   A+ +  + I  L  
Sbjct: 1305 ALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHA 1364

Query: 178  EKRKHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEK-------EKRVTTLKE 230
            +    K+ ME  D   CL  +  E +K+ + ++++   ++ +EK       EK  T L++
Sbjct: 1365 QVADMKKKME--DSVGCL--ETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQ 1420

Query: 231  ELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLA----LAEARVQEEEQ 286
            EL  L    L+ +D Q++    L  +++K  +L    K    K A     AEA  +E+E 
Sbjct: 1421 ELDDL----LVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKET 1476

Query: 287  KATRLEK----------ELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDE 336
            KA  L +          EL+    +F  + + +M+   +      +L++   AL +Q++E
Sbjct: 1477 KALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEE 1536

Query: 337  LEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQC 396
            ++     L + E+ELQ  ++   + E     + A+ E       D++G+DE+  + ++Q 
Sbjct: 1537 MKT---QLEELEDELQATEDAKLRLEVNLQAMKAQFER------DLQGRDEQSEEKKKQL 1587

Query: 397  ----RDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKER 452
                R++   LE E  Q        +KL   +  LE   D+ NK++ E       L K +
Sbjct: 1588 VRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIK---QLRKLQ 1644

Query: 453  MTTKQLSQEL-------ESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERK 505
               K   +EL       E +  + KE E     +E     L+E+L   +        ER 
Sbjct: 1645 AQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERD 1704

Query: 506  TMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTD-VEEKMYSVTKER 564
             +++++  +  K   A  + +  + ++  + E+L EE     +  T+ + +++     + 
Sbjct: 1705 ELADEIANSSGKGALALEEKRRLEARIAQLEEELEEE-----QGNTELINDRLKKANLQI 1759

Query: 565  DDLKNKLKAEE------EKGNDLLSRVNM-LKNRLQSLEAIEKDFLKNKLNQDSGKSTTA 617
            D +   L  E       E     L R N  LK +LQ +E   K   K  +     K    
Sbjct: 1760 DQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQL 1819

Query: 618  LHQENNKIKELS---QEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLS 674
              Q +N+ KE     ++V R + KLKD+      L++ +DE    E +Y ++ DKA   S
Sbjct: 1820 EEQLDNETKERQAACKQVRRTEKKLKDV------LLQVDDERRNAE-QYKDQADKA---S 1869

Query: 675  KELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKI 726
              L+ +K +L + +   +   +  + L + L++    +  ++REV +LK K+
Sbjct: 1870 TRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKL 1921



 Score =  116 bits (290), Expect = 1e-25
 Identities = 168/751 (22%), Positives = 317/751 (42%), Gaps = 124/751 (16%)

Query: 175  LEEEKRKHKEYMEKSDEFICLLEQECERLKKLIDQE-IKSQEEKEQEKEKRVTTLKEELT 233
            L +  R+ +E M K +E + + E++     +L + E ++SQ   E+ + +     + EL 
Sbjct: 837  LLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELC 896

Query: 234  KLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEK 293
                       E + L A+LT ++Q+++E+  +           EARV+EEE++     +
Sbjct: 897  A----------EAEELRARLTAKKQELEEICHDL----------EARVEEEEERC----Q 932

Query: 294  ELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQD 353
             LQ +  K  Q+   +  +L  E+S  ++LQ           E   T   L+K EEE   
Sbjct: 933  HLQAEKKKMQQNIQELEEQLEEEESARQKLQL----------EKVTTEAKLKKLEEEQII 982

Query: 354  IKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKM----EEQCRDLNKRLERETLQ 409
            ++++  K       +   + E    + + E K + L K+    E    DL +RL RE  Q
Sbjct: 983  LEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQ 1042

Query: 410  SKDF-----KLEVEK--LSKRIMALE----KLEDAFNKSKQECYSLKCNLEKERMTTKQL 458
             ++      KLE +   LS +I  L+    +L+    K ++E  +    +E+E       
Sbjct: 1043 RQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMA 1102

Query: 459  SQELESLKVRIKELE-------AIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEK- 510
             +++  L+ +I EL+       A  ++ EK +  L E+L  LKT     +D      E  
Sbjct: 1103 LKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELR 1162

Query: 511  ---------LKKT-EDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSV 560
                     LKKT E++ +   +Q+Q  + K +   E+L E+ ++  + K ++E+   ++
Sbjct: 1163 SKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTL 1222

Query: 561  TKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEA--------------------IEK 600
              ER +L N++K   +   D   +   ++ +LQ L+                     +E 
Sbjct: 1223 ENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVEL 1282

Query: 601  DFLKNKLNQDSGKST------TALHQENNKIKELSQEVERLKLKLK-DMKAIEDD----- 648
            D +   L+Q   KS+      +AL  +    +EL QE  R KL L   +K +ED+     
Sbjct: 1283 DNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFR 1342

Query: 649  --LMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQ 706
              L + E+    LE++ A    +   + K++E     L   +  ++      + L +R +
Sbjct: 1343 EQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHE 1402

Query: 707  EEEAKSGHLSREVDALKEKIHEYMATED----LICHLQGDHSVLQKKLNQQ--------E 754
            E+ A    L +    L++++ + +   D      C+L+       + L ++        E
Sbjct: 1403 EKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAE 1462

Query: 755  NRNRDLGREIENLTKELERYRHFSKSLRPSLNGRRISDPQVFSKEVQTEAVD---NEPPD 811
             R+R      E  TK L   R   +++       R+      +K+ +TE  D   ++   
Sbjct: 1463 ERDRAEAEAREKETKALSLARALEEAMEQKAELERL------NKQFRTEMEDLMSSKDDV 1516

Query: 812  YKSLIPLERAV-INGQLYEESENQDEDPNDE 841
             KS+  LE++     Q  EE + Q E+  DE
Sbjct: 1517 GKSVHELEKSKRALEQQVEEMKTQLEELEDE 1547



 Score = 92.0 bits (227), Expect = 3e-18
 Identities = 104/506 (20%), Positives = 228/506 (45%), Gaps = 46/506 (9%)

Query: 82   ELQARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQRDAFQAKSTPWQEDIYEKPMN 141
            +L A ++ I    AE+ D A  EA+        +  AL+ +A + K+    E + ++   
Sbjct: 1448 QLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALE-EAMEQKAE--LERLNKQFRT 1504

Query: 142  ELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICLLEQECE 201
            E++ ++   K+   + + +L  ++++  Q + E++ +  + ++ ++ +++    LE   +
Sbjct: 1505 EMEDLMSS-KDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQ 1563

Query: 202  RLKKLIDQEIKSQEEKEQEKEKR----VTTLKEELTKLKSFALMVVDEQQRLTAQLTLQR 257
             +K   +++++ ++E+ +EK+K+    V  ++ EL   +    M V  +++L   L    
Sbjct: 1564 AMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLE 1623

Query: 258  QKIQELTTNAKETHTKLALAEARVQE--EEQKATRLEKELQTQTTKFHQDQDTIMAKLTN 315
              I     N  E   +L   +A++++   E   TR  +E      K ++       KL +
Sbjct: 1624 AHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEK------KLKS 1677

Query: 316  EDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEEL 375
             +++  QLQ++LAA            R+ R+A++E  ++ ++I+      A  + E   L
Sbjct: 1678 MEAEMIQLQEELAA----------AERAKRQAQQERDELADEIANSSGKGALALEEKRRL 1727

Query: 376  RKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQ----SKDFKLEVEKLSKRIMALEKLE 431
              R+  +E   EEL + +     +N RL++  LQ    + D  LE     K   A ++LE
Sbjct: 1728 EARIAQLE---EELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLE 1784

Query: 432  DAFNKSKQECYSLKCNLEKERMTT-----KQLSQELESLKVRIKELEAIESRLEKTEFTL 486
                + K +   ++  ++ +   +      +++Q  E L    KE +A   ++ +TE  L
Sbjct: 1785 RQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKL 1844

Query: 487  KEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRA 546
            K+ L +        VD+ +  +E+ K   DK      QL+ +  +     ++     ++ 
Sbjct: 1845 KDVLLQ--------VDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKL 1896

Query: 547  LKSKTDVEEKMYSVTKERDDLKNKLK 572
             +   D  E   ++ +E   LKNKL+
Sbjct: 1897 QRELEDATETADAMNREVSSLKNKLR 1922


>gi|71061468 centromere protein E [Homo sapiens]
          Length = 2701

 Score =  132 bits (331), Expect = 2e-30
 Identities = 173/718 (24%), Positives = 325/718 (45%), Gaps = 100/718 (13%)

Query: 114  KVLEALQRDAFQAKSTPWQEDIYEKPMNELD--KVVEKHKESYRRILGQLLVAEKSRRQT 171
            K+ E    D F+A     ++D   + ++E+   K + KH E Y + L   L    S+ + 
Sbjct: 527  KLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENEL---SSKVEL 583

Query: 172  ILELEEEKRKHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEE 231
            + E E++ +K +EY++          Q+ E +K  +   ++S E+ +Q        +K+ 
Sbjct: 584  LREKEDQIKKLQEYIDS---------QKLENIKMDLSYSLESIEDPKQ--------MKQT 626

Query: 232  LTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRL 291
            L   ++ AL    E   L ++    ++K++EL T  K+    + L +++++ +++    L
Sbjct: 627  LFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDL 686

Query: 292  EKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEEL 351
            EKELQ+   +  +    I  K+  +   N +L+ K+  L +++++  E N +LR+    L
Sbjct: 687  EKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILL 746

Query: 352  QDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSK 411
             ++K            + +EVE LRK + D   K EEL  +  +   L   +  +  + +
Sbjct: 747  SELK-----------SLPSEVERLRKEIQD---KSEELHIITSEKDKLFSEVVHKESRVQ 792

Query: 412  DFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLE-KERMT---TKQLSQELESLKV 467
                E+ K    +   +    + ++  Q   +L  + E K +M     ++++QE+ +L  
Sbjct: 793  GLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLS- 851

Query: 468  RIKELEAIESRLE--KTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQL 525
              KE +  +S L   KTE + K    + KT     V ER    E+LK   ++L+   S L
Sbjct: 852  --KEAQKFDSSLGALKTELSYKTQELQEKTRE---VQERLNEMEQLK---EQLENRDSTL 903

Query: 526  QVEQNKVTTVTEKL---IEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLL 582
            Q  + + T +TEKL   +EE K   + K D+++   S+  ERD LK+ +    +  N  +
Sbjct: 904  QTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDI---HDTVNMNI 960

Query: 583  SRVNMLKNRLQSLEAIEK--DFLKNKLNQDSGKSTTALHQENNKIK---ELSQEV----E 633
                 L+N L+SL+  ++  + LK+K++++  ++   LH E N  +   E  Q++    +
Sbjct: 961  DTQEQLRNALESLKQHQETINTLKSKISEEVSRN---LHMEENTGETKDEFQQKMVGIDK 1017

Query: 634  RLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHV--KMELAKYKLAE 691
            +  L+ K+ + +  D+   ++E    +R+  +   +   L + LE V  + E  K  L E
Sbjct: 1018 KQDLEAKNTQTLTADV--KDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKE 1075

Query: 692  KTETSHEQWLFKRLQEEE----------------AKSGHLSREVD-------ALKEKIHE 728
              E + E     RL  +E                 K G LSR  D        LKEK  +
Sbjct: 1076 NIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQ 1135

Query: 729  YMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPSLN 786
                +  + ++Q + S +QKK+N+ EN    L  E++N    LE        L   LN
Sbjct: 1136 LQEKQQQLLNVQEEMSEMQKKINEIEN----LKNELKNKELTLEHMETERLELAQKLN 1189



 Score =  118 bits (295), Expect = 4e-26
 Identities = 182/850 (21%), Positives = 370/850 (43%), Gaps = 144/850 (16%)

Query: 76   LSILEGELQARDEVIGILKAEKMDLALLEAQYGFVTPK--KVLEALQRDAFQAKSTPWQE 133
            L +L  EL+ + E++     EK      E +      +  +V E L+  + Q +    Q 
Sbjct: 1087 LRLLGDELKKQQEIVA---QEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQL 1143

Query: 134  DIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEFI 193
               ++ M+E+ K + + +     +        K++  T+  +E E+ +  + + ++ E +
Sbjct: 1144 LNVQEEMSEMQKKINEIENLKNEL--------KNKELTLEHMETERLELAQKLNENYEEV 1195

Query: 194  CLLEQECERLKKLIDQ-EIKSQEEKEQEKEKRVTTL--KEELTKLKSFALM----VVDEQ 246
              + +E + LK+L    E +    +   +E   T L  KEEL K+    L      +DE 
Sbjct: 1196 KSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEEL-KIAHIHLKEHQETIDEL 1254

Query: 247  QRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQ 306
            +R  ++ T Q    Q+L    +++HTKL      + EE++    +++  +TQ T    + 
Sbjct: 1255 RRSVSEKTAQIINTQDL----EKSHTKLQEEIPVLHEEQELLPNVKEVSETQETM--NEL 1308

Query: 307  DTIMAKLTNEDSQN-RQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGN 365
            + +  + T +DS    +++ +   L+ +  E +E  +SL K  + L+ IKE +   E  +
Sbjct: 1309 ELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEAL---EVKH 1365

Query: 366  AGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRL-ERETLQSKD---FKLEVEKL- 420
              +   + E   ++ + + K E+ + M+E+  +  K + E E  + KD    ++E+E L 
Sbjct: 1366 DQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLG 1425

Query: 421  -SKRIMA--------------LEKLEDAFN------------------KSKQECYSLKCN 447
             SKR+                L++L++                     ++++E     C 
Sbjct: 1426 LSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCC 1485

Query: 448  LEKERMTTKQLSQELESLKVRI----KELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDE 503
            L+++  T  +L   L   +  I    K+LEAI  +L+     ++E   K +   +  + E
Sbjct: 1486 LKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQN---KIQEIYEKEEQFNIKQISE 1542

Query: 504  RKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKL---IEETKRALKSKTDVEEKMYSV 560
             +    +LK+ ++  +A  S LQ  ++K+  +T +L    EE +  +K K +++    ++
Sbjct: 1543 VQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEAL 1602

Query: 561  TKERDDLKN-------KLKAEEEKGNDLL--SRVNMLKNRLQSLEAIEKDFLKNKLNQDS 611
              ERD LK        K+K  +EK    L  + VN  + ++  +E +++ F   KLN ++
Sbjct: 1603 QIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLEN 1662

Query: 612  GKS-----TTALHQENNKIKELSQE------------VERLKLKLKDMKAIEDDLMKTE- 653
             ++     T  LH+   +++ +++E            VER +LK    + I  DL K E 
Sbjct: 1663 IETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEE 1722

Query: 654  ---------DEYETLERRYANERDKAQFLS---KELEHVK--MELAKYKLAEKTETSH-- 697
                     +  ET+++      +K   +S   K+LEH    ++    K+ E+   +H  
Sbjct: 1723 LKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMH 1782

Query: 698  ---EQWLFKRLQ----EEEAKSGHLSREVD----ALKEKIHEYMATEDLICHLQGDHSVL 746
               +Q    +L+    E+  K  ++ ++++     L+EKI E  A E  +  L+ D +  
Sbjct: 1783 LKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNET 1842

Query: 747  QKKLNQQENRNRDL--------GREIENLT---KELERYRHFSKSLRPSLNGRRISDPQV 795
            QKK+++ E   + +          EIENL    K  E        ++   N RR+ +   
Sbjct: 1843 QKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLK 1902

Query: 796  FSKEVQTEAV 805
              ++   E++
Sbjct: 1903 LERDQLKESL 1912



 Score =  108 bits (271), Expect = 2e-23
 Identities = 162/798 (20%), Positives = 353/798 (44%), Gaps = 96/798 (12%)

Query: 79   LEGELQARDEVIGILKAE------KMDLALLEAQYGFVTPKKVLEALQ-RDAFQAKSTPW 131
            L  E Q  D  +G LK E      ++     E Q      +++ E L+ RD+        
Sbjct: 850  LSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVERE 909

Query: 132  QEDIYEKPMNELDKV--VEKHKESYRRILGQLLVAEKSRRQTI-------LELEEEKRKH 182
            +  I EK    L++V  + + K+  +++   L +     +  I       ++ +E+ R  
Sbjct: 910  KTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNA 969

Query: 183  KEYMEKSDEFICLLEQEC-ERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALM 241
             E +++  E I  L+ +  E + + +  E  + E K++ ++K V   K++  + K+   +
Sbjct: 970  LESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTL 1029

Query: 242  VVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTK 301
              D +     ++  Q++KI  L     E    L   E+ + E+EQ  T L++ ++  T +
Sbjct: 1030 TADVKDN---EIIEQQRKIFSLIQEKNELQQML---ESVIAEKEQLKTDLKENIE-MTIE 1082

Query: 302  FHQDQDTIMAKLTNEDS----QNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEK 357
              ++   +  +L  +      +     +K   LSR  D L E    L++  ++LQ+ +++
Sbjct: 1083 NQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQ 1142

Query: 358  ISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDL-NKRLERETLQSKDFKLE 416
            +         +  E+ E++K++ ++E    EL   E     +  +RLE     +++++ E
Sbjct: 1143 L-------LNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYE-E 1194

Query: 417  VEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAI- 475
            V+ ++K    L++L+ +F   +     L+  + +   T  Q  +EL+   + +KE +   
Sbjct: 1195 VKSITKERKVLKELQKSFETERDH---LRGYIREIEATGLQTKEELKIAHIHLKEHQETI 1251

Query: 476  -ESRLEKTEFT--------LKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQ 526
             E R   +E T        L++  TKL+    +  +E++ +    + +E +      +L 
Sbjct: 1252 DELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELL 1311

Query: 527  VEQN--KVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSR 584
             EQ+  K +T   ++  E  R  +   + +E++ S+TKERD+LK   +A E K + L   
Sbjct: 1312 TEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEH 1371

Query: 585  VNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKL----K 640
            +     ++Q  ++ ++  L  K   +    TT +  E  + K     + R+++++    K
Sbjct: 1372 IRETLAKIQESQSKQEQSLNMK---EKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSK 1428

Query: 641  DMKAIEDDL---MKTEDEYETLERRYANERDK-----AQFLSKELE-HVKMELAKYKLAE 691
             ++   D++    K +D+ + L+    +E D+      + ++K LE   ++++A   L E
Sbjct: 1429 RLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKE 1488

Query: 692  KTETSHEQWLFKRLQEEEAKSGHLSREVDA----LKEKIHEYMATEDLIC---------- 737
            + ET +E  L   L E+E +   + ++++A    L+ KI E    E+             
Sbjct: 1489 QEETINE--LRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEK 1546

Query: 738  ---------HLQGDHSVLQ---KKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPSL 785
                     H +   S LQ    K+ +  NR ++   EI+ + KE E  +   ++L+   
Sbjct: 1547 VNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIER 1606

Query: 786  NGRRISDPQVFSKEVQTE 803
            +  + +  ++ +K  +++
Sbjct: 1607 DQLKENTKEIVAKMKESQ 1624



 Score =  107 bits (268), Expect = 5e-23
 Identities = 154/723 (21%), Positives = 316/723 (43%), Gaps = 97/723 (13%)

Query: 117  EALQRDAFQAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELE 176
            E  Q    + KS   + D  +     L+   ++ KE  R  L ++  ++  + Q++   E
Sbjct: 1335 EKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKE 1394

Query: 177  EEKRKHK-----EYMEKSDEFICLLEQECERLKKLIDQ---EIKSQEEKEQEKEKRVTTL 228
            ++    K     E  +  D  +  +E E   L K + +   E+KS  +++ + ++    L
Sbjct: 1395 KDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVL 1454

Query: 229  KEELTKLKSFALMVVDEQQRLTAQLTL-------QRQKIQELTTNAKETHTKLALAEARV 281
            + E  +LK     +V +      +L +       Q + I EL  N  E  T+++  + ++
Sbjct: 1455 QSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQL 1514

Query: 282  QEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDE--LEE 339
            +    K     +E+  +  +F+  Q + + +  NE  Q ++ ++   +  + I+   LE 
Sbjct: 1515 EAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLEL 1574

Query: 340  TNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDL 399
            TNR L++++EE+Q               IM + +E  KRV   E    E  +++E  +++
Sbjct: 1575 TNR-LQESQEEIQ---------------IMIKEKEEMKRV--QEALQIERDQLKENTKEI 1616

Query: 400  NKRLERETLQSKDFKL----EVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTT 455
              +++    Q K+++      V +  +++  +E L++ F   K        N+E E +  
Sbjct: 1617 VAKMKES--QEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLE----NIETENIRL 1670

Query: 456  KQLSQE-LESLKVRIKE---LEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKL 511
             Q+  E LE ++   KE   L ++E  L+     LKE+L +  T  +   +E K +   L
Sbjct: 1671 TQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHL 1730

Query: 512  KKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKT-DVEEKM---YSVTKERDDL 567
            K+ ++ +      +  + N+++ + +K +E +  ALK++   ++E++   +   KE+ + 
Sbjct: 1731 KEHQETIDKLRGIVSEKTNEISNM-QKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQET 1789

Query: 568  KNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKE 627
             +KL+    +  D LS  NM K+   S   +++   + K N+        L ++ N+ ++
Sbjct: 1790 IDKLRGIVSEKTDKLS--NMQKDLENSNAKLQEKIQELKANEHQ---LITLKKDVNETQK 1844

Query: 628  LSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKY 687
               E+E+LK ++KD       L K E E   L ++     ++ + + KE ++++      
Sbjct: 1845 KVSEMEQLKKQIKDQSLT---LSKLEIENLNLAQKLHENLEEMKSVMKERDNLRR----- 1896

Query: 688  KLAEKTETSHEQWLFKRLQEEEAKSGHLSRE--------------VDALKEKIHE-YMAT 732
               E+T       L + LQE +A+   + +E              VD L+EKI E  +  
Sbjct: 1897 --VEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQI 1954

Query: 733  EDLICHLQGDHSVLQKKLNQQENRNRDLGR-------------EIENLTKELERYRHFSK 779
             D+   L      LQKK+ + + +   L R             E+E L K+ E      +
Sbjct: 1955 SDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQ 2014

Query: 780  SLR 782
            S+R
Sbjct: 2015 SVR 2017



 Score = 86.7 bits (213), Expect = 1e-16
 Identities = 131/635 (20%), Positives = 289/635 (45%), Gaps = 91/635 (14%)

Query: 210 EIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKE 269
           E+ + E   +   K +  LK++L ++         E+ +L AQL  ++  +Q++     E
Sbjct: 337 EVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQL-AQLLEEKDLLQKVQNEKIE 395

Query: 270 THTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAA 329
             T++ +  + +  +++   + ++ +     K ++ +++  A   N  +       KL+ 
Sbjct: 396 NLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLS- 454

Query: 330 LSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNA-------GIMAEVEELR----KR 378
               I+ L E + S+    +   +  + +S+ E+  A        I +E+  LR      
Sbjct: 455 ----INLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNL 510

Query: 379 VLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKL---EDAFN 435
           VLD E    E  +ME + ++ N   E E L+ K  K +  +L   I  L+ L    + +N
Sbjct: 511 VLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYN 570

Query: 436 KSKQECYSLKCNLEKERM-TTKQL-----SQELESLKVRIK-ELEAIE--SRLEKTEF-- 484
           +  +   S K  L +E+    K+L     SQ+LE++K+ +   LE+IE   ++++T F  
Sbjct: 571 QDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDA 630

Query: 485 -----TLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQ---------- 529
                  K +   L++  +   ++ K ++   K+ E+ +Q   SQL+ ++          
Sbjct: 631 ETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKEL 690

Query: 530 ----NKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRV 585
               N++T +T  +  +  + L    ++E K+        DL+ +L  E E+ N+ L   
Sbjct: 691 QSAFNEITKLTSLIDGKVPKDLLCNLELEGKI-------TDLQKELNKEVEE-NEALREE 742

Query: 586 NMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKI-KELSQEVERLKLKLKDMKA 644
            +L + L+SL + E + L+ ++ QD  +    +  E +K+  E+  +  R++  L+++  
Sbjct: 743 VILLSELKSLPS-EVERLRKEI-QDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGK 800

Query: 645 IEDDLMKTEDEYETLERRYANER--------------DKAQFLSKELEHVKMELAKYKL- 689
            +DDL  T+  Y++ ++ + N +              ++ + +++E+ ++  E  K+   
Sbjct: 801 TKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSS 860

Query: 690 --AEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQ 747
             A KTE S++    + LQE+  +      E++ LKE++    +T   +   + + +++ 
Sbjct: 861 LGALKTELSYKT---QELQEKTREVQERLNEMEQLKEQLENRDSTLQTV---EREKTLIT 914

Query: 748 KKLNQQENRNRDLGREIENLTKELERYRHFSKSLR 782
           +KL Q          E++ LT+E +  +   +SL+
Sbjct: 915 EKLQQTL-------EEVKTLTQEKDDLKQLQESLQ 942



 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 157/782 (20%), Positives = 335/782 (42%), Gaps = 144/782 (18%)

Query: 63   QAEDLSRDDLLFLLSILEGELQARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQRD 122
            +A+D +   +   +  L   LQ   E I I+  EK ++            K+V EALQ +
Sbjct: 1558 KAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEM------------KRVQEALQIE 1605

Query: 123  AFQAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKH 182
              Q K         E     + K+ E  ++ Y+ +    +   + +   I  L+E+    
Sbjct: 1606 RDQLK---------ENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQ 1656

Query: 183  KEYMEKSD----EFICLLEQECERLKKLIDQ--EIKSQEE-----KEQEKEKRVTTLKEE 231
            K  +E  +        +L +  E ++ +  +  +++S EE     ++Q KE    T+  +
Sbjct: 1657 KLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRD 1716

Query: 232  LTK---LKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETH--------------TKL 274
            L K   LK   + + + Q+ +     +  +K  E++   K+                 +L
Sbjct: 1717 LEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEEL 1776

Query: 275  ALAEARVQEEEQKATRLEKELQTQTTKF---HQDQDTIMAKLTNEDSQNRQLQQKLAALS 331
             +A   ++E+++   +L   +  +T K     +D +   AKL  +  + +  + +L  L 
Sbjct: 1777 RIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLK 1836

Query: 332  RQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIK 391
            + ++E ++    + + +++++D    +SK E  N  +    ++L + + +M+   +E   
Sbjct: 1837 KDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNL---AQKLHENLEEMKSVMKE--- 1890

Query: 392  MEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKE 451
                 RD  +R+E ETL     KLE           ++L+++  ++K     ++  L+  
Sbjct: 1891 -----RDNLRRVE-ETL-----KLE----------RDQLKESLQETKARDLEIQQELKTA 1929

Query: 452  RMTTKQLSQELESLKVRIKE----LEAIESRLEKTEFTLKEDLTKL--KTLTVMFVDERK 505
            RM +K+  + ++ L+ +I E    +  I+  L+K++  L++ + +L  K L ++ V E  
Sbjct: 1930 RMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDV 1989

Query: 506  TMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERD 565
             MS    K  ++++    Q + +   + +V     + TK+  +S     E++  V KERD
Sbjct: 1990 NMSH---KKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESL----EEIRIVAKERD 2042

Query: 566  DLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKI 625
            +L+   ++ + + +  ++ +  +  R +    ++ +  K  L+      T +L ++ ++I
Sbjct: 2043 ELRRIKESLKMERDQFIATLREMIARDRQNHQVKPE--KRLLSDGQQHLTESLREKCSRI 2100

Query: 626  KELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELA 685
            KEL +    +                 +D YE L R   +   + +F  +    VK  L+
Sbjct: 2101 KELLKRYSEM-----------------DDHYECLNRLSLDLEKEIEFQKELSMRVKANLS 2143

Query: 686  ----KYKLAEKTETSHEQ--WLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDL---- 735
                + K  EK  T++++    F R+ +   K  ++   V  +KE+ HE +   ++    
Sbjct: 2144 LPYLQTKHIEKLFTANQRCSMEFHRIMK---KLKYVLSYVTKIKEEQHESINKFEMDFID 2200

Query: 736  -----------ICHLQGDHSVLQKKLNQQE-NRNRDLGREIENLTKELERYRHFSKSLRP 783
                       I HLQ D  V  ++L   + N+N DL   IE + K+      FS+S  P
Sbjct: 2201 EVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDL--HIEEILKD------FSESEFP 2252

Query: 784  SL 785
            S+
Sbjct: 2253 SI 2254



 Score = 80.1 bits (196), Expect = 1e-14
 Identities = 142/735 (19%), Positives = 313/735 (42%), Gaps = 131/735 (17%)

Query: 145  KVVEKHKESYRRILGQLLVAEKSRRQTI-------LELEEE-------KRKHKEYMEKSD 190
            K V K +++ RR+   L +     ++++       LE+++E        ++HKE ++K  
Sbjct: 1885 KSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLR 1944

Query: 191  EFICLLEQECERLKKLIDQ---EIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQ 247
            E I     +   ++K +D+   E++ + ++ Q+KE ++  +KE++    + +   ++E +
Sbjct: 1945 EKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDV----NMSHKKINEME 2000

Query: 248  RLTAQLTLQRQKIQELTTNAKETHTKL--ALAEARVQEEEQKATRLEKELQTQTTKFHQD 305
            +L  Q   Q   +Q +  +  +   KL  +L E R+  +E+   R  KE    + K  +D
Sbjct: 2001 QLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKE----SLKMERD 2056

Query: 306  QD-TIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYG 364
            Q    + ++   D QN Q++ +   LS   D  +    SLR+    ++++ ++ S+ +  
Sbjct: 2057 QFIATLREMIARDRQNHQVKPEKRLLS---DGQQHLTESLREKCSRIKELLKRYSEMD-- 2111

Query: 365  NAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFK---------- 414
                    E L +  LD+E   +E+   +E    +   L    LQ+K  +          
Sbjct: 2112 -----DHYECLNRLSLDLE---KEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCS 2163

Query: 415  LEVEKLSKRIMAL--------EKLEDAFNKSKQECYSLKCNLEKER---MTTKQLSQELE 463
            +E  ++ K++  +        E+  ++ NK + +       +EK++   +  + L Q+ +
Sbjct: 2164 MEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFID---EVEKQKELLIKIQHLQQDCD 2220

Query: 464  SLKVRIKELEAIESRLEKTEFTLKE----DLTKLKTLTVMFVDERKTMSEKLKK---TED 516
                 +++L+  ++     E  LK+    +   +KT     +  RK M++ L++   T  
Sbjct: 2221 VPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRF 2280

Query: 517  KLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEE 576
             ++   + +Q E +++  V           +   T+ EE+  +++KE    +  LK+ +E
Sbjct: 2281 DIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKE---WEQDLKSLKE 2337

Query: 577  KGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKST-------------------TA 617
            K   L      LK  L S   +      NK    + ++T                   +A
Sbjct: 2338 KNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESA 2397

Query: 618  LHQENNKIKELSQEVE-------RLKLKLKDMKAIEDDLMKTEDEYETLERRYA--NERD 668
            +H+E +KI ++ +E+E       +L+ K+ +       L KT++  + L+ + A   +  
Sbjct: 2398 MHKE-SKIIKMQKELEVTNDIIAKLQAKVHESNKC---LEKTKETIQVLQDKVALGAKPY 2453

Query: 669  KAQFLSKELEHVKMELAKYKLAEKTE--------TSHEQWLFKRLQEEEAKSGHLSREVD 720
            K +    +++ VK++L K K A++ E        T   Q    RL  E  +    +++  
Sbjct: 2454 KEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTS 2513

Query: 721  ALKEKIHEYMATEDLICH-------------LQGDHSVLQKKLNQQENRNRDLGREIENL 767
             + E      + + L C              L+ +H  L+K++++ + +N  L   I+  
Sbjct: 2514 VISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQL---IKQK 2570

Query: 768  TKELERYRHFSKSLR 782
             + L   +H S  ++
Sbjct: 2571 NELLSNNQHLSNEVK 2585



 Score = 34.3 bits (77), Expect = 0.69
 Identities = 49/245 (20%), Positives = 101/245 (41%), Gaps = 30/245 (12%)

Query: 79   LEGELQARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQRDAFQAKSTPWQEDIYEK 138
            ++ EL+  +++I  L+A+     + E+       K+ ++ LQ D     + P++E+I + 
Sbjct: 2407 MQKELEVTNDIIAKLQAK-----VHESNKCLEKTKETIQVLQ-DKVALGAKPYKEEIEDL 2460

Query: 139  PMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICLLEQ 198
             M  +   +EK K +                    E E+E    K  +E   E I LL +
Sbjct: 2461 KMKLVKIDLEKMKNAK-------------------EFEKEISATKATVEYQKEVIRLLRE 2501

Query: 199  ECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQ 258
               R ++  D  + S+    Q   K +T          + AL++  E  RL  +++  +Q
Sbjct: 2502 NLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQ 2561

Query: 259  KIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDS 318
            + ++L     E  +        V+  +++   L++E   Q T  +  +     K+T   S
Sbjct: 2562 QNEQLIKQKNELLSNNQHLSNEVKTWKERT--LKREAHKQVTCENSPKS---PKVTGTAS 2616

Query: 319  QNRQL 323
            + +Q+
Sbjct: 2617 KKKQI 2621


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score =  127 bits (320), Expect = 5e-29
 Identities = 193/832 (23%), Positives = 357/832 (42%), Gaps = 131/832 (15%)

Query: 34  RQQDKDSPSESDVILPCP----------KAEKPHSGNGHQAEDLSRDDLLFLLSILEGEL 83
           +Q+ ++ P   DV+ P P          K E P S      ED +       +  LE   
Sbjct: 232 KQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTS------VKTLETLQ 285

Query: 84  QARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQRDAFQAKSTPWQEDIYEKPMNEL 143
           Q       +LK  K  +   + Q   +T +K  EALQ                ++ + EL
Sbjct: 286 QRVKRQENLLKRCKETIQSHKEQCTLLTSEK--EALQEQL-------------DERLQEL 330

Query: 144 DKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKH-KEYMEKSDEFICLLEQECER 202
           +K+ + H     +++ QL    +  +  I +LE++K     E   +  E + + E+E  +
Sbjct: 331 EKIKDLHMAEKTKLITQL----RDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQ 386

Query: 203 LKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFA--------------------LMV 242
           L+  I Q     EE  ++KEK      EEL K  S A                    +  
Sbjct: 387 LRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEK 446

Query: 243 VDEQQRLTAQLTLQRQKIQELTTNAKETHTKLA-LAEARVQEEEQKATRLEKELQTQTTK 301
             E++R++ Q  L R K + +    K +  ++A L +   +E  +K   L K+LQT+  +
Sbjct: 447 TSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTRERE 506

Query: 302 FHQDQDTIMAKLTNE---DSQNRQLQQKLAALSRQIDELEETNRS-LRKAEEELQDIKEK 357
           F +     + K  +E    SQ ++ Q+ LA     ++ELE   ++ L ++E +L+D+++ 
Sbjct: 507 FQEQMKVALEKSQSEYLKISQEKEQQESLA-----LEELELQKKAILTESENKLRDLQQ- 560

Query: 358 ISKGEYGNAGIMAEVEELRKRVLDMEGK-DEELIKMEEQCRDLNKRLERE-TLQSKDFKL 415
                        E E  R R+L++E   ++ L + + Q +DL   LE E    +K+  +
Sbjct: 561 -------------EAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITV 607

Query: 416 EVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKEL--- 472
            VEK    + +L+  +DA    K +    +   E E++  K   QE E+L ++ KE+   
Sbjct: 608 MVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREK-CEQEKETL-LKDKEIIFQ 665

Query: 473 EAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKV 532
             IE   EKT   L    T+L++L+         +SE L K   KL+   S L+ + +K+
Sbjct: 666 AHIEEMNEKTLEKLDVKQTELESLS-------SELSEVL-KARHKLEEELSVLKDQTDKM 717

Query: 533 TTVTEKLIEETKRALKSKTD--VEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKN 590
               E  ++E K   + + D  ++E   S+ +    LK+++   E     L  R   LK 
Sbjct: 718 KQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELL---LKERDKHLKE 774

Query: 591 RLQSLEAIEKDFLKN--KLNQDSGK------STTALHQENNKIKELSQEVERLKLKLKDM 642
               +E +E D  ++  +L Q S K        +A H++    K   +++ +L+ KL D+
Sbjct: 775 HQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQT---KAYEEQLAQLQQKLLDL 831

Query: 643 KAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLF 702
           +     L K   E E  ++    E D  +   ++L          +  EK  +  EQ + 
Sbjct: 832 ETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDL---------MQQLEKQNSEMEQKVK 882

Query: 703 KRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHL----QGDHSVLQKKLNQQENRNR 758
              Q  E+K    ++E +  K+ + E    E++I  +    + +  +L +KL+ +E+   
Sbjct: 883 SLTQVYESKLEDGNKEQEQTKQILVE---KENMILQMREGQKKEIEILTQKLSAKEDSIH 939

Query: 759 DLGREIE----NLTKELERYRHFSKSLRPSLNGRRISDPQVFSKEVQTEAVD 806
            L  E E    N  K++E+ +  +K ++ +L  + +       KE++  A++
Sbjct: 940 ILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALE 991



 Score =  107 bits (266), Expect = 8e-23
 Identities = 149/698 (21%), Positives = 303/698 (43%), Gaps = 111/698 (15%)

Query: 167  SRRQTILELEEEKRKHKEYMEKSDEFICLLEQECERL---KKLIDQEIKSQEEKEQEKEK 223
            +  Q  L +  ++  H+  +E+ +  I  ++ + E L   K+ + +E  +Q++   EKE 
Sbjct: 1282 TEEQNTLNISFQQATHQ--LEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKES 1339

Query: 224  RVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKET----HTKLALAEA 279
             +T LK+EL++  +   ++ +E +    +++   +++ +L    + +      + A++  
Sbjct: 1340 CITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSL 1399

Query: 280  RVQEEEQKATRLEK--------------------ELQTQTTKFHQDQDTIMAKLTNEDSQ 319
            R Q +E+K   L++                    ++   + KF + +    ++ T   + 
Sbjct: 1400 RKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNT 1459

Query: 320  NRQLQQKLAALSRQI-----------DELEETNRSLRKAEEELQDIKEKISKGEYGNAGI 368
             ++LQ +L   S++            +EL++ N+     + E++D K K+ K E   + +
Sbjct: 1460 VKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKE---SNL 1516

Query: 369  MAEVEELRKRVLDMEG----KDEELIKMEEQCRDLN--KRLERETLQSK--DFKLEVEKL 420
              E++    R++++E     K  E+  + E  ++ N  K +E + L  K   F+   E+ 
Sbjct: 1517 ETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEK 1576

Query: 421  SKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLE 480
              R+   ++ E+     + + YS+K  LE ++   K+L     S+K + +EL+A+E RLE
Sbjct: 1577 DNRV---KEAEEKILTLENQVYSMKAELETKK---KELEHVNLSVKSKEEELKALEDRLE 1630

Query: 481  KTEFTLKEDLT-----KLKTLTVMFVDERKTMSEKLKK-TEDKLQAASSQLQVEQNKVTT 534
                    +L      K+  +    + + +   E+ KK TE  L   +++LQ  + +V  
Sbjct: 1631 SESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHI 1690

Query: 535  VTEKL----IEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEK----------GND 580
            + EKL      +++  +  ++      Y+  +E D      K  EEK             
Sbjct: 1691 LEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEK 1750

Query: 581  LLSRVNMLKN---------RLQSLEAIEK-DFLKNKLNQDS---GKSTTALHQENNKIKE 627
            LL RV   K          R Q  E + K +  + K ++D    G     L ++N K   
Sbjct: 1751 LLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSL 1810

Query: 628  L-SQEVERLKLK-----LKDMKAIEDDLMKTEDEYET----LERRYANERDKAQFLSKEL 677
            + +Q VE+   K      ++++ + DD+ KT  E E     LE++   E D      KE+
Sbjct: 1811 IVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKI-KELDSCLVRQKEV 1869

Query: 678  EHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLIC 737
              V+ME    +L  K E        + LQ+ + ++       +  +EK   ++    L+ 
Sbjct: 1870 HRVEME----ELTSKYEK------LQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLS 1919

Query: 738  HLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYR 775
            +++  H+ L+ KL   E   + LG+EI  L K+L   R
Sbjct: 1920 NMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLR 1957



 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 153/712 (21%), Positives = 306/712 (42%), Gaps = 89/712 (12%)

Query: 114  KVLEALQRDAFQAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTIL 173
            K  EA ++D  Q      + D   K  + L   +E  K    +    L    KS+   I+
Sbjct: 1470 KSKEAYEKDE-QINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIM 1528

Query: 174  ELEEEKRKHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELT 233
            ELE+   +    +E  +E +    Q+ +   K + Q+++  +E  +EK+ RV   +E++ 
Sbjct: 1529 ELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKIL 1588

Query: 234  KLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEE--------- 284
             L+       ++   + A+L  ++++++ +  + K    +L   E R++ E         
Sbjct: 1589 TLE-------NQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELK 1641

Query: 285  ---EQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETN 341
               EQK   ++K+L +Q     ++++    K T  +S   +L  KL    R++  LEE  
Sbjct: 1642 RKAEQKIAAIKKQLLSQM----EEKEEQYKKGT--ESHLSELNTKLQEREREVHILEEKL 1695

Query: 342  RSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNK 401
            +S+  ++ E   +          N     E EE   +    +  +E++  ++    +  K
Sbjct: 1696 KSVESSQSETLIVPRSAK-----NVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEK 1750

Query: 402  RL-----ERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNL-EKERMTT 455
             L     E+E   S  F++  +   +R++ LE  E   ++ +     L+  L EK +  +
Sbjct: 1751 LLQRVGQEKEETVSSHFEMRCQ-YQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYS 1809

Query: 456  KQLSQ--ELESLKVRIKELEAIESRLEKTEFTLKE-DLT------KLKTLTVMFVDERKT 506
              ++Q  E E  K  I+  + +E+  +  + TL+E +LT      K+K L    V +++ 
Sbjct: 1810 LIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEV 1869

Query: 507  MSEKLKKTEDKLQAASSQLQVE-QNKVTTVTEKLIEETKRALKSKTD-VEEKMYS-VTKE 563
               ++++   K +   +  Q++ +NK T + E+  EE     KSK+  V+ K+ S +  +
Sbjct: 1870 HRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEE-----KSKSHLVQPKLLSNMEAQ 1924

Query: 564  RDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSL---EAIEKDFLKNKLNQDSGKSTTALHQ 620
             +DL+ KL   E +   L   +  L+  L+ L      E + LK + +Q+          
Sbjct: 1925 HNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQE---------- 1974

Query: 621  ENNKIKELSQEVERLKLK----LKD-MKAIEDDLMKTEDEYETLERRYANERDKAQFLSK 675
               + +++ QE E L+LK    LK  M+     L + E E E   +   N+  + +    
Sbjct: 1975 ---REEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELL 2031

Query: 676  ELEHVKMELAKYKLAEK------TETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEY 729
            E    +      K+AEK      T   +E+ L  R +E  AK   L  +++ L++K  + 
Sbjct: 2032 ESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQK 2091

Query: 730  MATED-------LICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERY 774
            +  E+        I  LQ   +     ++  + + ++   +I NL   L++Y
Sbjct: 2092 LEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKKY 2143



 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 138/707 (19%), Positives = 293/707 (41%), Gaps = 88/707 (12%)

Query: 31   MKHRQQDKDSPSESDVILPCPKAEKPHSGNGHQAEDLSRDDLLFLLSILEGELQARDEVI 90
            ++ ++Q+     +  ++  C K E        + E + +D  L   + L+ +L+ +   +
Sbjct: 1066 LQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTL---NELQEQLKQKSAHV 1122

Query: 91   GILKAEKMDLALLEAQYGFVTPKKVLEALQRDAFQAKSTPWQEDIYEKPMNELDKVVEKH 150
              L  ++  L            K  LE L+ D  ++     +    ++ + EL  + E+ 
Sbjct: 1123 NSLAQDETKL------------KAHLEKLEVDLNKSLK---ENTFLQEQLVELKMLAEED 1167

Query: 151  KESYRRILGQLLVAEKSRRQTILELEEEKR----KHKEYMEKSDEFICLLEQECERLKKL 206
            K     +  +L   ++  +      E+  +    K  E+ + S+E    L+  C++ + L
Sbjct: 1168 KRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEAL 1227

Query: 207  IDQE----IKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQE 262
            ++ +    I     K      R++  +   TK+K   L+       L AQL    ++   
Sbjct: 1228 LEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNT 1287

Query: 263  LTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQ 322
            L  + ++   +L   E +++  +     L  E +    +    Q     K +      ++
Sbjct: 1288 LNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKE 1347

Query: 323  LQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDM 382
            L + + A++   +EL+E    +    ++L D+  ++ +     +   A +  LRK+    
Sbjct: 1348 LSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQL-QNSISLSEKEAAISSLRKQY--- 1403

Query: 383  EGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSK-RIMALEKLEDAFNKSKQEC 441
               DEE  ++ +Q +DL+               +V+ LSK +I ALE+++D  NK  +  
Sbjct: 1404 ---DEEKCELLDQVQDLS--------------FKVDTLSKEKISALEQVDDWSNKFSEWK 1446

Query: 442  YSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFV 501
               +    + + T K+L  +LE   ++ KE    + ++   +  L +   +   L     
Sbjct: 1447 KKAQSRFTQHQNTVKELQIQLE---LKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEME 1503

Query: 502  DERKTMSEKLKKTEDKLQAASSQLQVEQNKVT--TVTEKLIEETKRALKSKTDVEEKMYS 559
            D++  M +K    E +L++ ++++   ++ +T  T+  + + E  +    + D+E K   
Sbjct: 1504 DDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHK--- 1560

Query: 560  VTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALH 619
                  +L  KL+  +E G +  +RV   + ++ +LE        N++     +  T   
Sbjct: 1561 ------ELVQKLQHFQELGEEKDNRVKEAEEKILTLE--------NQVYSMKAELET--- 1603

Query: 620  QENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEH 679
                K KEL      +K K +++KA+ED L ++E   +  E +   E+  A    + L  
Sbjct: 1604 ----KKKELEHVNLSVKSKEEELKALEDRL-ESESAAKLAELKRKAEQKIAAIKKQLLSQ 1658

Query: 680  VKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKI 726
            ++ +  +YK   K   SH   L  +LQE E       REV  L+EK+
Sbjct: 1659 MEEKEEQYK---KGTESHLSELNTKLQERE-------REVHILEEKL 1695



 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 82/380 (21%), Positives = 167/380 (43%), Gaps = 48/380 (12%)

Query: 19   HTKGHSFQGPKNMKHRQQDKDSPSESDVILPCPKAEKPHSGNGHQAEDLSRDDLLFLLSI 78
            H +    +    + H Q++ +  ++   ++     EK    N  QA    + +L  +   
Sbjct: 1782 HAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQA----KQNLENVFDD 1837

Query: 79   LEGELQARDEVIGIL--KAEKMDLALLE------AQYGFVTPK-KVLEALQRDAFQAKST 129
            ++  LQ ++    IL  K +++D  L+        +   +T K + L+ALQ+   + K T
Sbjct: 1838 VQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPT 1897

Query: 130  PW-QEDIYEKPMNEL--DKVVEKHKESYRRILGQLLVAEKSRRQT---ILELEEE----K 179
               +E+  EK  + L   K++   +  +  +  +L  AE+ +++    I+ L+++    +
Sbjct: 1898 ELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLR 1957

Query: 180  RKH--------KEYMEKSDEFICLLEQECE-----RLKKLIDQEIKSQEEKEQEKEKRVT 226
            ++H        KEY ++ +E I   +++ E      LK+L+ +      +KEQE E    
Sbjct: 1958 KEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEM--- 2014

Query: 227  TLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQ 286
            T+KE + K +     +++  Q  T QL    +KI E   + K T  +    E  +   E+
Sbjct: 2015 TIKETINKAQEVEAELLESHQEETNQLL---KKIAEKDDDLKRTAKRY---EEILDAREE 2068

Query: 287  KATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQN---RQLQQKLAALSRQIDELEETNRS 343
            + T   ++LQTQ  +  +     + +  N  + N    +LQ +LA  +  I + +   + 
Sbjct: 2069 EMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQE 2128

Query: 344  LRKAEEELQDIKEKISKGEY 363
             R+    L+D  +K  K  Y
Sbjct: 2129 FREQIHNLEDRLKKYEKNVY 2148



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 99/445 (22%), Positives = 184/445 (41%), Gaps = 109/445 (24%)

Query: 478 RLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTE 537
           R+E++  + +   ++L T   M   E+K +   L +++DK     ++L+ E        +
Sbjct: 145 RMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREELQMDQQAKK 204

Query: 538 KLIEETKRALKSK---TDVEEKMYSVTKER--------DDLK---------NKLKAEEEK 577
            L EE   +L+ K     V +   S+ K+R        D LK              EE  
Sbjct: 205 HLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENP 264

Query: 578 GND----------------LLSRVNMLKNRLQ-------------SLEAIEKDFLKNKLN 608
            +D                L  RV   +N L+             +L   EK+ L+ +L+
Sbjct: 265 ESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLD 324

Query: 609 Q--------------DSGKSTTALHQENNKIKELSQEV------------ERLKLKLKDM 642
           +              +  K  T L    N I++L Q+             E L++K +++
Sbjct: 325 ERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEI 384

Query: 643 KAIEDDL--MKTEDEYETLERRYANERDKAQFLSKELEHV-KMELAKYKLAEKTETSHEQ 699
             +   +  M T+ E E  E++  +ER   + L K L    K E A+ KL  K E   + 
Sbjct: 385 AQLRSRIKQMTTQGE-ELREQKEKSERAAFEELEKALSTAQKTEEARRKL--KAEMDEQI 441

Query: 700 WLFKRLQEEEAKSGHLSREVDALKEKIHEYM--ATEDLICHLQGDHSVLQKKLNQQENRN 757
              ++  EEE  S  L +E+  +K+++ + M  ++E+ I  LQ        KL+++E   
Sbjct: 442 KTIEKTSEEERIS--LQQELSRVKQEVVDVMKKSSEEQIAKLQ--------KLHEKE--- 488

Query: 758 RDLGREIENLTKELE-RYRHFSKSLRPSLNGRRISDPQVFSKEVQTEAVDNEPPDYKSLI 816
             L R+ + LTK+L+ R R F + ++ +L   +    ++  ++ Q E++  E  + +   
Sbjct: 489 --LARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQ--- 543

Query: 817 PLERAVINGQLYEESENQDEDPNDE 841
             ++A++      ESEN+  D   E
Sbjct: 544 --KKAILT-----ESENKLRDLQQE 561


>gi|45439327 periplakin [Homo sapiens]
          Length = 1756

 Score =  124 bits (312), Expect = 4e-28
 Identities = 164/667 (24%), Positives = 293/667 (43%), Gaps = 106/667 (15%)

Query: 32   KHRQQDKDSPSESDVILPCPKAEKPHSG--NGHQAEDLSRDDLLFLLSILEGELQARDE- 88
            K R Q+K +  E   +   P+ E  +      HQ +D  R+     LS L+ +L+  ++ 
Sbjct: 1045 KSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKE 1104

Query: 89   ---------VIGILKAEKMDLALLEAQYGFVTPKKVLEALQRDAFQAKSTPWQEDIYEKP 139
                     V  +LK EK   A  E +   +T +   EA +  A Q + T     I+   
Sbjct: 1105 RAMAEGKITVKEVLKVEKD--AATEREVSDLTRQYEDEAAKARASQREKTELLRKIWALE 1162

Query: 140  MNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICLLEQE 199
                  VV+   E  R I+     AE       LEL E++RK++   E+   +   LE  
Sbjct: 1163 EENAKVVVQ---EKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSELEAL 1219

Query: 200  CER-----LKKLIDQEIKSQEEKEQEKEKR-------------------VTTLKEELTKL 235
              R     +K++  + IK + + E EKE +                   +  LK+E+  L
Sbjct: 1220 RRRGPQVEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQAL 1279

Query: 236  KSFALMVV------------------DEQQRLTAQLTLQRQKIQELTTNAKETHTKLALA 277
            K     V                   +E   L A+L+ +++K  +L         ++A  
Sbjct: 1280 KDTKPQVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIARK 1339

Query: 278  E---ARVQEE--EQKATRLEKE--LQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAAL 330
            E   +RV+E   +Q+  R E+E  L+ + + F +  D  + ++    ++ R+LQ++   L
Sbjct: 1340 EEELSRVKERVVQQEVVRYEEEPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTEL 1399

Query: 331  SRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLD---MEGKDE 387
             RQ++ELE   ++ R+AE E+Q ++++++  E   A    +V   +K VL     + ++ 
Sbjct: 1400 ERQLEELERERQARREAEREVQRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREH 1459

Query: 388  ELIKM---EEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSL 444
             L+++   EEQ R      E ETL+ K   LE  ++ ++++  E ++     ++QE   L
Sbjct: 1460 ALLRLQLEEEQHRRQLLEGELETLRRKLAALEKAEVKEKVVLSESVQVEKGDTEQEIQRL 1519

Query: 445  KCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDER 504
            K +LE+E  + ++L  E+  L+ R+ ELE   S+  K    L+E+               
Sbjct: 1520 KSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKELDFLREE--------------- 1564

Query: 505  KTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKER 564
               + KL+     LQ  + +LQ E N   T T  L   T     S T+ + +++S+ +E 
Sbjct: 1565 ---NHKLQLERQNLQLETRRLQSEINMAATETRDLRNMT--VADSGTNHDSRLWSLEREL 1619

Query: 565  DDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNK 624
            DDLK        K  DL   ++ L+ RL S+ A++++  +N L     +S   +H +   
Sbjct: 1620 DDLKRL-----SKDKDL--EIDELQKRLGSV-AVKREQRENHLR----RSIVVIHPDTG- 1666

Query: 625  IKELSQE 631
             +ELS E
Sbjct: 1667 -RELSPE 1672



 Score =  102 bits (254), Expect = 2e-21
 Identities = 161/734 (21%), Positives = 320/734 (43%), Gaps = 98/734 (13%)

Query: 79   LEGELQARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEA----LQRDAF--QAKSTPWQ 132
            LE E+++  E I  L+ +    +++  +     P  VLE     LQR     Q K+   Q
Sbjct: 909  LENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLLQ 968

Query: 133  EDI--YEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQT--ILELEEEKRKHKEYMEK 188
            E++   +  +  L++      + Y  ++ ++L  E  R Q   +L+L EE    +     
Sbjct: 969  EELEALQLQLRALEQETRDGGQEY--VVKEVLRIEPDRAQADEVLQLREELEALRRQKGA 1026

Query: 189  SDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQR 248
             +  + LL+Q   R+  L +++ ++QE+     EK V  L+ +  +L++    + ++ QR
Sbjct: 1027 REAEVLLLQQ---RVAALAEEKSRAQEKVT---EKEVVKLQND-PQLEAEYQQLQEDHQR 1079

Query: 249  LTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDT 308
                   Q +++  L    K    + A+AE ++  +E    ++EK+  T+     ++   
Sbjct: 1080 QDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKE--VLKVEKDAATE-----REVSD 1132

Query: 309  IMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGI 368
            +  +  +E ++ R  Q++   L R+I  LEE N  +   +E++++I     K E      
Sbjct: 1133 LTRQYEDEAAKARASQREKTELLRKIWALEEENAKV-VVQEKVREIVRPDPKAE------ 1185

Query: 369  MAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALE 428
             +EV  LR  +++ E K       EEQ R     LE   L+ +  ++EV++++K ++  +
Sbjct: 1186 -SEVANLRLELVEQERKYRGA---EEQLRSYQSELE--ALRRRGPQVEVKEVTKEVIKYK 1239

Query: 429  ---KLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEF- 484
               ++E    + ++E       +E+  +   QL +E+++LK    +++  E   E  +F 
Sbjct: 1240 TDPEMEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQ 1299

Query: 485  ----------TLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTT 534
                      +L+  L++ +   V    ER +  E++ + E++L     ++ V+Q  V  
Sbjct: 1300 EDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELSRVKERV-VQQEVVRY 1358

Query: 535  VTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQS 594
              E  +     A     DVE       ++ D L+ +L+  + +  +L  ++  L+   Q+
Sbjct: 1359 EEEPGLRAEASAFAESIDVE------LRQIDKLRAELRRLQRRRTELERQLEELERERQA 1412

Query: 595  LEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKT-- 652
                E++       Q   +   AL QE  + +E     +++ L+    +A E  L++   
Sbjct: 1413 RREAEREV------QRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRLQL 1466

Query: 653  ----------EDEYETLERRYANERDKAQFLSKEL--EHVKMELA---------KYKLAE 691
                      E E ETL R+ A   +KA+   K +  E V++E           K  L E
Sbjct: 1467 EEEQHRRQLLEGELETLRRKLA-ALEKAEVKEKVVLSESVQVEKGDTEQEIQRLKSSLEE 1525

Query: 692  KTETSHE-----QWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVL 746
            ++ +  E       L  RL E E  +   S+E+D L+E+ H+         +LQ +   L
Sbjct: 1526 ESRSKRELDVEVSRLEARLSELEFHNSKSSKELDFLREENHKLQLERQ---NLQLETRRL 1582

Query: 747  QKKLNQQENRNRDL 760
            Q ++N      RDL
Sbjct: 1583 QSEINMAATETRDL 1596



 Score = 85.5 bits (210), Expect = 3e-16
 Identities = 147/689 (21%), Positives = 302/689 (43%), Gaps = 111/689 (16%)

Query: 164  AEKSRRQTILELEEEKRKHKEYMEKSDEFICLLEQ-------ECERLKKLIDQEIKSQEE 216
            A K R++   E E  ++   E     +E   L  Q         E LKK+ D  ++   +
Sbjct: 892  AWKIRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLEESFQ 951

Query: 217  KEQ----EKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHT 272
            + Q    E++ +   L+EEL  L+   L  ++++ R   Q  + ++ ++ +  +  +   
Sbjct: 952  QLQRTLAEEQHKNQLLQEELEALQ-LQLRALEQETRDGGQEYVVKEVLR-IEPDRAQADE 1009

Query: 273  KLALAEARVQEEEQKATRLEKE---LQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAA 329
             L L E       QK  R E E   LQ +     +++     K+T ++    Q   +L A
Sbjct: 1010 VLQLREELEALRRQKGAR-EAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEA 1068

Query: 330  LSRQIDELEETNRSLR-KAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEE 388
              +Q+ E  +    LR K EEEL  +++K+ + E   A  MAE +   K VL +E KD  
Sbjct: 1069 EYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERA--MAEGKITVKEVLKVE-KDAA 1125

Query: 389  LIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALE----------KLEDAFN--- 435
                E +  DL ++ E E  +++  + E  +L ++I ALE          K+ +      
Sbjct: 1126 T---EREVSDLTRQYEDEAAKARASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDP 1182

Query: 436  KSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKT 495
            K++ E  +L+  L ++    +   ++L S +    ELEA+  R  + E    +++TK   
Sbjct: 1183 KAESEVANLRLELVEQERKYRGAEEQLRSYQ---SELEALRRRGPQVEV---KEVTK--- 1233

Query: 496  LTVMFVDERKTMSEKLK-KTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVE 554
                         E +K KT+ +++    +L+          E+++++T+  L  + D+E
Sbjct: 1234 -------------EVIKYKTDPEMEKELQRLR----------EEIVDKTR--LIERCDLE 1268

Query: 555  EKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKS 614
              +Y + KE   LK+     + K  +++  +   +   Q+ E +    L+ KL+++  K 
Sbjct: 1269 --IYQLKKEIQALKDTKPQVQTK--EVVQEILQFQEDPQTKEEVAS--LRAKLSEEQKKQ 1322

Query: 615  TTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLS 674
                 +  ++ ++++++ E L  ++K+ + ++ ++++ E+E        A     A+ + 
Sbjct: 1323 VDLERERASQEEQIARKEEELS-RVKE-RVVQQEVVRYEEE----PGLRAEASAFAESID 1376

Query: 675  KELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKI----HEYM 730
             EL  +    A+ +  ++  T  E+ L + L+ E        REV  L++++     E  
Sbjct: 1377 VELRQIDKLRAELRRLQRRRTELERQL-EELERERQARREAEREVQRLQQRLAALEQEEA 1435

Query: 731  ATEDLICHLQG-----------DHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSK 779
               + + H Q            +H++L+ +L ++++R + L  E+E L ++L        
Sbjct: 1436 EAREKVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEGELETLRRKL-------- 1487

Query: 780  SLRPSLNGRRISDPQVFSKEVQTEAVDNE 808
                +L    + +  V S+ VQ E  D E
Sbjct: 1488 ---AALEKAEVKEKVVLSESVQVEKGDTE 1513



 Score = 81.6 bits (200), Expect = 4e-15
 Identities = 159/744 (21%), Positives = 317/744 (42%), Gaps = 114/744 (15%)

Query: 165  EKSRRQTILELEEEKRKHKEYMEKSDEFICLLEQECERLKKLIDQE--IKSQEEKEQEKE 222
            +K+    I   E+E +K     ++  + +   E E E+L+ L+D E    S   K    +
Sbjct: 770  QKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLRSLLDLENGRSSHVSKRARLQ 829

Query: 223  KRVTTLKEELTKL--KSFALMVVDEQ--QRLTAQLTLQRQKIQELTTNAKETHTKLALAE 278
               T +KEE   L  K   +  ++ Q  Q L   L L RQ+ +   T+         L  
Sbjct: 830  SPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQQPEVEVTHE-------TLQR 882

Query: 279  ARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELE 338
             R     ++A ++ KEL  +T +  Q ++ +  K T E+    + Q    ++ R+ + L+
Sbjct: 883  NRPDSGVEEAWKIRKELDEETERRRQLENEV--KSTQEEIWTLRNQGPQESVVRK-EVLK 939

Query: 339  ETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVE--ELRKRVLDMEGKD-------EEL 389
            +    +   EE  Q ++  +++ ++ N  +  E+E  +L+ R L+ E +D       +E+
Sbjct: 940  KVPDPV--LEESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEV 997

Query: 390  IKME------EQCRDLNKRLERETLQSKDFKLEVEKLSKRIMAL--EKLEDAFNKSKQEC 441
            +++E      ++   L + LE    Q    + EV  L +R+ AL  EK       +++E 
Sbjct: 998  LRIEPDRAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEV 1057

Query: 442  YSLKCN---------LEKERMTTKQL----SQELESLKVRIKELEAIESRLEKTEFTLKE 488
              L+ +         L+++     QL     +EL  L+ ++K LE  E  + + + T+KE
Sbjct: 1058 VKLQNDPQLEAEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEK-ERAMAEGKITVKE 1116

Query: 489  DL---------TKLKTLTVMFVDE-RKTMSEKLKKTE--DKLQAASSQLQVEQNKVTTVT 536
             L          ++  LT  + DE  K  + + +KTE   K+ A       E+N    V 
Sbjct: 1117 VLKVEKDAATEREVSDLTRQYEDEAAKARASQREKTELLRKIWALE-----EENAKVVVQ 1171

Query: 537  EKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLE 596
            EK+ E  +   K++++V      + ++    + K +  EE+     S +  L+ R   +E
Sbjct: 1172 EKVREIVRPDPKAESEVANLRLELVEQ----ERKYRGAEEQLRSYQSELEALRRRGPQVE 1227

Query: 597  A--IEKDFLKNKLNQDSGKSTTALHQE-----------NNKIKELSQEVERL---KLKLK 640
               + K+ +K K + +  K    L +E           + +I +L +E++ L   K +++
Sbjct: 1228 VKEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQALKDTKPQVQ 1287

Query: 641  DMKAIEDDLM-----KTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTET 695
              + +++ L      +T++E  +L  + + E+ K   L +E    + ++A+ +  E+   
Sbjct: 1288 TKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKE--EELSR 1345

Query: 696  SHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQEN 755
              E+ + + +   E + G L  E  A  E I   +   D           L+ +L + + 
Sbjct: 1346 VKERVVQQEVVRYEEEPG-LRAEASAFAESIDVELRQID----------KLRAELRRLQR 1394

Query: 756  RNRDLGREIENLTKELERYRHFSKS---LRPSLNGRRISDPQVFSKEVQTEAV--DNEPP 810
            R  +L R++E L +E +  R   +    L+  L      + +   K   T+ V    +P 
Sbjct: 1395 RRTELERQLEELERERQARREAEREVQRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQ 1454

Query: 811  DYKSLIPLERAVINGQLYEESENQ 834
              +     E A++  QL EE   +
Sbjct: 1455 QAR-----EHALLRLQLEEEQHRR 1473



 Score = 75.5 bits (184), Expect = 3e-13
 Identities = 139/681 (20%), Positives = 279/681 (40%), Gaps = 98/681 (14%)

Query: 219  QEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQ-------------LTLQRQKIQELTT 265
            Q+  +R   LK    +L    L +  E+ R TA+               L R ++++  T
Sbjct: 540  QDSAERAKDLKNITNEL----LRIEPEKTRSTAEGEAFIQALPGSGTTPLLRTRVED--T 593

Query: 266  NAKETHTKLALAEARVQEEEQKATRLEKELQTQ-----TTKFHQDQDTIMAKLTNEDSQN 320
            N K  H    L  A  QE+   A RLEK LQ       T + H +QD  + +       +
Sbjct: 594  NRKYEHLLQLLDLA--QEKVDVANRLEKSLQQSWELLATHENHLNQDDTVPE------SS 645

Query: 321  RQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVL 380
            R L  K   L+    EL+     L + E+ LQ  K+  S                ++   
Sbjct: 646  RVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSS----------TLASRFQEHCP 695

Query: 381  DMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSK-RIMALEKLEDAFNKSKQ 439
            D+E ++ E+ K+ ++  +L +++ER     +  K   E   +     L+ L    +   Q
Sbjct: 696  DLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEPQ 755

Query: 440  ECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVM 499
            E  SL   +E +    K L  E+ S +  ++++ A   + ++                  
Sbjct: 756  ETDSLS-QMETKLKNQKNLLDEIASREQEVQKICANSQQYQQA----------------- 797

Query: 500  FVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYS 559
             V + +  +EKL+   D     SS +       +  T+  ++E + AL +K     ++Y+
Sbjct: 798  -VKDYELEAEKLRSLLDLENGRSSHVSKRARLQSPATK--VKEEEAALAAKFT---EVYA 851

Query: 560  VTKER-DDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTAL 618
            + ++R  +L+  L    ++    ++   + +NR  S   +E+ +   K+ ++  + T   
Sbjct: 852  INRQRLQNLEFALNLLRQQPEVEVTHETLQRNRPDS--GVEEAW---KIRKELDEETERR 906

Query: 619  HQENNKIKELSQEVERLKLKLKDMKAIEDDLMKT------EDEYETLERRYANERDKAQF 672
             Q  N++K   +E+  L+ +      +  +++K       E+ ++ L+R  A E+ K Q 
Sbjct: 907  RQLENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQL 966

Query: 673  LSKELEHVKMELAKYKLAEKTETSHEQWLFK---RLQEEEAKSG---HLSREVDALKE-- 724
            L +ELE ++++L    L ++T    ++++ K   R++ + A++     L  E++AL+   
Sbjct: 967  LQEELEALQLQLR--ALEQETRDGGQEYVVKEVLRIEPDRAQADEVLQLREELEALRRQK 1024

Query: 725  --KIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLR 782
              +  E +  +  +  L  + S  Q+K+ ++E        ++E   ++L+        LR
Sbjct: 1025 GAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLR 1084

Query: 783  PSLNGRRISDPQVFSKEVQTE-AVDNEPPDYKSLIPLERAVINGQLYEESENQDEDPNDE 841
                   +S  Q   K ++ E A+       K ++ +E+         E E  D     E
Sbjct: 1085 EK-QEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAAT-----EREVSDLTRQYE 1138

Query: 842  GSVLSFKCSQSTPCPVNRKLW 862
                  + SQ     + RK+W
Sbjct: 1139 DEAAKARASQREKTELLRKIW 1159


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score =  124 bits (311), Expect = 5e-28
 Identities = 157/762 (20%), Positives = 329/762 (43%), Gaps = 79/762 (10%)

Query: 79   LEGELQARDEVIGILKAEKMDL-ALLEAQYGFVTPKKVLEALQRDAFQAKSTPWQEDIYE 137
            LE  LQ   E I +L+ E+ DL A ++A  G        E    +  Q K+   QE + +
Sbjct: 528  LEALLQKSKENISLLEKEREDLYAKIQAGEG--------ETAVLNQLQEKNHTLQEQVTQ 579

Query: 138  KPMNELDKVVEKHKESYRRILGQLLVAE---KSRRQTILELEEEKRKHKEYMEKSDEFIC 194
                +L    E HK++   +  Q+   +   ++ +  +L LE    +    + +S E + 
Sbjct: 580  LT-EKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVS 638

Query: 195  LLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLT 254
             L+ + +   +L+     ++  +  + +  + T +  L   +     +  +  ++TA+L 
Sbjct: 639  QLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQ 698

Query: 255  LQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKE-LQTQTTKFHQDQDTIMAKL 313
             +++   +L ++ KE   K    E + +E E +  +LE + L+ + +K    QD    + 
Sbjct: 699  DKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQ 758

Query: 314  TNED--------SQNRQLQQKLAA-----LSRQIDELEETNRSLRKAEEELQDIKE---- 356
             N D        S+  ++++++ +     L ++ + LE   + L K EEE Q +K+    
Sbjct: 759  LNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFET 818

Query: 357  -----KISKGEYGNAGIMAEVEELRKRVLDMEGK-------DEELIKMEEQCRDLNKRLE 404
                 KI   E  N  I   V EL+K  ++ E          ++L K+ +  ++     E
Sbjct: 819  LSQETKIQHEELNNR-IQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFE 877

Query: 405  RETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELES 464
            +E  + K   L++EK  K +    +L+     + +E   LK +LEKE+  + QL  EL S
Sbjct: 878  KENQKGKAAILDLEKTCKELK--HQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNS 935

Query: 465  LKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLK-----------K 513
            ++ ++ + +    + EK E  L+ ++ +LK  +     + + +  +LK           K
Sbjct: 936  MQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENK 995

Query: 514  TEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKA 573
             + +L  A+ +L  E+ K++ +     +  +   + ++D   +   +   R DLK+  + 
Sbjct: 996  LQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEK 1055

Query: 574  EEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKEL----- 628
                  DL+S  N + N+ + ++ ++    K  L QDS K    L +    ++++     
Sbjct: 1056 LSLAQEDLISNRNQIGNQNKLIQELKT--AKATLEQDSAKKEQQLQERCKALQDIQKEKS 1113

Query: 629  --SQEVERLKLKLKDMKAI----EDDLMKTEDEYETLE----RRYANERDKAQFLSKELE 678
               +E+   K KL +++ I    E ++ K  +E ++ +    +   N +D  Q L ++  
Sbjct: 1114 LKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKL 1173

Query: 679  HVKMELAKYKLAEKTETSHEQWLFKRL--QEEEAKSGHLSREV---DALKEKIHEYMATE 733
             ++ +    K A + E  ++Q L  ++  +EEE K   + +E      +KEK       E
Sbjct: 1174 ELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHE 1233

Query: 734  DLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYR 775
            +    L    + L + L   +   +   R +  L K+ +  R
Sbjct: 1234 ENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLR 1275



 Score =  117 bits (292), Expect = 8e-26
 Identities = 125/644 (19%), Positives = 290/644 (45%), Gaps = 42/644 (6%)

Query: 160  QLLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQ 219
            +LL  E+   +    L+E+++   E +   ++ +  L+ +  RL++ + +++ +  E + 
Sbjct: 422  KLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQH 481

Query: 220  EKEKRVTTLKEELTKLKSFALMVVDEQ---QRLTAQLTLQRQKIQELTTNAKETHTKLAL 276
            + +K     +E+    +S    + + Q   +++  Q+  + QKIQ L    +++   ++L
Sbjct: 482  QLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISL 541

Query: 277  AE-------ARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAA 329
             E       A++Q  E + T +  +LQ +     +    +  KL N+   ++Q Q+ L  
Sbjct: 542  LEKEREDLYAKIQAGEGE-TAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLH- 599

Query: 330  LSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEEL 389
                 D+++E    LR A++ +  ++  +++    N+ +    E++ +  + ++ K E L
Sbjct: 600  -----DQVQEQKAHLRAAQDRVLSLETSVNEL---NSQLNESKEKVSQLDIQIKAKTELL 651

Query: 390  IKMEE----QCRDLNKRLERETLQSKDFKLEVEKLSKRI-MALEKLEDAFNKSKQECYSL 444
            +  E     Q  DL   L+      +D + E+ K++ ++     KL+D     ++ C  L
Sbjct: 652  LSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQD----KQEHCSQL 707

Query: 445  KCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDER 504
            + +L++ +     L Q+ E L+ +IK+LEA    ++ ++    +DL + + L        
Sbjct: 708  ESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRA 767

Query: 505  KTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKER 564
              +S++L+  ++ + +    LQ +   + ++ +KL ++ +     K D E        + 
Sbjct: 768  TELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQH 827

Query: 565  DDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNK 624
            ++L N+++    +    L +V M K  L +  +  KD L +K++     S +   +EN K
Sbjct: 828  EELNNRIQTTVTE----LQKVKMEKEALMTELSTVKDKL-SKVSDSLKNSKSEFEKENQK 882

Query: 625  IKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMEL 684
             K    ++E+   +LK    ++  +  T  E + L++    E++ +  L  EL  ++ +L
Sbjct: 883  GKAAILDLEKTCKELKHQLQVQ--MENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQL 940

Query: 685  AKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHS 744
             + +   K     EQ L   + E +  S    ++++AL+ ++   +  +  +       +
Sbjct: 941  IQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTEL------EN 994

Query: 745  VLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPSLNGR 788
             LQ++L Q          +I  L    E+ +   K L+    GR
Sbjct: 995  KLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGR 1038



 Score =  113 bits (283), Expect = 9e-25
 Identities = 161/798 (20%), Positives = 350/798 (43%), Gaps = 76/798 (9%)

Query: 80  EGELQARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQRDAFQAKSTPWQEDIYEKP 139
           +G  Q   +  G++     +L  LE Q         LE  Q + F  K     +D++E+ 
Sbjct: 117 QGLQQQEAKPDGLVTDSSAELQSLEQQ---------LEEAQTENFNIKQ---MKDLFEQK 164

Query: 140 MNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKR-----KHKEYMEKSDEFIC 194
             +L   +   K  Y         AE+   +   EL +E       K +       E + 
Sbjct: 165 AAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVA 224

Query: 195 LLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLT 254
           +L++E  +++ L+D     +E + ++ +     L+ +    ++    +  E  +   ++ 
Sbjct: 225 VLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVA 284

Query: 255 LQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLT 314
           +  Q++Q+L ++  E   K       + ++EQ  T+LE++   ++      +  I A L 
Sbjct: 285 VYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESV----SKKNIQATLH 340

Query: 315 NEDSQNRQLQQKLAA----LSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMA 370
            +D   +QLQ +L+A    L R   EL E   + +K +EEL +++ K    +     +  
Sbjct: 341 QKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQ 400

Query: 371 EVEELRKRVLDMEGK----DEELIKMEEQCRDLNKRL-ERETLQSKDFKLEVEKLSKRIM 425
           + EE  +  L ++ +      +L++ E Q  + + RL E+  L S+    + ++++   +
Sbjct: 401 QREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQL 460

Query: 426 ALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESL-KVRIKELEAIESRLEKTEF 484
            L +LE+   +       L+  L+K    TKQ  QE ++L +    +L   ++ LE+   
Sbjct: 461 KLSRLEEQLKEKVTNSTELQHQLDK----TKQQHQEQQALQQSTTAKLREAQNDLEQVLR 516

Query: 485 TLKEDLTKLKTLTVMFVDERKTMSEKLKKTED---KLQAAS------SQLQVE----QNK 531
            + +   K++ L  +    ++ +S   K+ ED   K+QA        +QLQ +    Q +
Sbjct: 517 QIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQ 576

Query: 532 VTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNR 591
           VT +TEKL  +++   +++ ++ +++          ++++ + E   N+L S++N  K +
Sbjct: 577 VTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEK 636

Query: 592 LQSLEAIEKDFLKNKLNQDSGKSTTALHQEN------NKIKELSQEVERLKLKLKDMKAI 645
           +  L+   K   +  L+ ++ K+      +N      N +++  QE+ ++  +L  + A 
Sbjct: 637 VSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTA- 695

Query: 646 EDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRL 705
              L   ++    LE      ++K   L ++ E ++ ++ K +       + ++   + L
Sbjct: 696 --KLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDL 753

Query: 706 QEE-------EAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNR 758
           Q++       E ++  LS++++  KE +       DL    +   S+ Q KL +QE   +
Sbjct: 754 QQQRQLNTDLELRATELSKQLEMEKEIVSS--TRLDLQKKSEALESIKQ-KLTKQEEEKQ 810

Query: 759 DLGREIENLTKELERYRHFSKSLRPSLNGR-RISDPQVFSKEVQTEAVDNEPPDYK-SLI 816
            L ++ E L++E       +K     LN R + +  ++   +++ EA+  E    K  L 
Sbjct: 811 ILKQDFETLSQE-------TKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLS 863

Query: 817 PLERAVINGQLYEESENQ 834
            +  ++ N +   E ENQ
Sbjct: 864 KVSDSLKNSKSEFEKENQ 881



 Score =  102 bits (254), Expect = 2e-21
 Identities = 156/724 (21%), Positives = 291/724 (40%), Gaps = 131/724 (18%)

Query: 169 RQTILELEEEKRKHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTL 228
           RQ + +L+   ++ K Y E+       L++E E+ + L  QE K         +  VT  
Sbjct: 89  RQEVQDLQASLKEEKWYSEE-------LKKELEKYQGLQQQEAKP--------DGLVTDS 133

Query: 229 KEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKA 288
             EL  L+        E   +     L  QK  +L T   +  +K     +  +  EQK 
Sbjct: 134 SAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKV 193

Query: 289 TRLEKELQTQTTKFHQDQDTIMAKLTNEDSQ--NRQLQQKLAALSRQIDELEETNRSLR- 345
           TRL +EL  + T     +  ++ +   ED     ++L Q    +     E E  +  L+ 
Sbjct: 194 TRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKD 253

Query: 346 ----------KAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKD----EELIK 391
                      +E  +  ++ +++KG    A  + E+++L+  V ++  K+    E L+K
Sbjct: 254 ECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLK 313

Query: 392 MEEQCRDLNKRLERETLQSKDFK-------LEVEKLSKRIMA-----------LEKLEDA 433
            E+    L ++   E++  K+ +       L+ ++L  R+ A           L +  +A
Sbjct: 314 KEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEA 373

Query: 434 FNKSKQECYSLKCNLEKERMTTKQLSQELESLKVR----IKELEAIESRLEKTEFTLKED 489
             K K+E   ++   +  +   KQL Q+ E  +        E+  + S+L +TE  L E 
Sbjct: 374 TQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEA 433

Query: 490 LTKLKTLTVMFVDERKTMSEKLKKTEDK---LQAASSQLQVE-QNKVTTVTE--KLIEET 543
             +LK       ++R+  SEKL   E +   LQ   S+L+ + + KVT  TE    +++T
Sbjct: 434 HGRLK-------EQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKT 486

Query: 544 KRALKSKTDVEEKMYSVTKE-RDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEK-- 600
           K+  + +  +++   +  +E ++DL+  L+   +K   + +   +L+   +++  +EK  
Sbjct: 487 KQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKER 546

Query: 601 DFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKD------------------- 641
           + L  K+    G+ T  L+Q   K   L ++V +L  KLK+                   
Sbjct: 547 EDLYAKIQAGEGE-TAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQ 605

Query: 642 ---MKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTE---- 694
              ++A +D ++  E     L  +    ++K   L  +++  K EL     A KT     
Sbjct: 606 KAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIK-AKTELLLSAEAAKTAQRAD 664

Query: 695 -TSHEQWLFKRLQEEEA------------------KSGHLSREVDALKEKIHEYMATEDL 735
             +H       LQ+++                   K  H S+    LKE   +Y++ E  
Sbjct: 665 LQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQK 724

Query: 736 ICHLQGDHSVLQ--------------KKLNQQENRNRDLGREIENLTKELERYRHFSKSL 781
              L+G    L+              + L QQ   N DL      L+K+LE  +    S 
Sbjct: 725 TEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSST 784

Query: 782 RPSL 785
           R  L
Sbjct: 785 RLDL 788



 Score = 99.4 bits (246), Expect = 2e-20
 Identities = 141/665 (21%), Positives = 286/665 (43%), Gaps = 111/665 (16%)

Query: 116  LEALQRDAFQAKSTPWQ--EDIYEKPM---------NELDKVVEKHKE---SYRRILGQL 161
            ++ L+ D+ + K++  Q  +D+ ++            EL K +E  KE   S R  L + 
Sbjct: 732  IKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKK 791

Query: 162  LVAEKSRRQTILELEEEKRKHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEK 221
              A +S +Q + + EEEK+              +L+Q+ E L     QE K Q E   E 
Sbjct: 792  SEALESIKQKLTKQEEEKQ--------------ILKQDFETLS----QETKIQHE---EL 830

Query: 222  EKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLAL----A 277
              R+ T   EL K+K        E++ L  +L+  + K+ +++ + K + ++        
Sbjct: 831  NNRIQTTVTELQKVKM-------EKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKG 883

Query: 278  EARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDEL 337
            +A + + E+    L+ +LQ Q     ++Q  +   L  E   + QL+ +L ++  Q+ + 
Sbjct: 884  KAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQA 943

Query: 338  EETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCR 397
            + T +   K E++LQ           GN   + +  E +K+   +E    EL     Q  
Sbjct: 944  QNTLKQNEKEEQQLQ-----------GNINELKQSSEQKKK--QIEALQGELKIAVLQKT 990

Query: 398  DLNKRLERETLQS-KDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTK 456
            +L  +L+++  Q+ ++   E EK+S      EK ++ F + + + Y  +  L   R   K
Sbjct: 991  ELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLK 1050

Query: 457  QLSQELE--------------SLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVD 502
             + ++L               +    I+EL+  ++ LE+ +   KE   + +   +  + 
Sbjct: 1051 SVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQ-DSAKKEQQLQERCKALQDIQ 1109

Query: 503  ERKTMSEKLKKTEDKLQAASSQLQVEQNK-VTTVTEKLIEETKRALKSKTDVEEKMYSVT 561
            + K++ EK    E    A   +++  Q K +T + E+L      ++K  T++++    + 
Sbjct: 1110 KEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLI 1169

Query: 562  KERDDLKNK---LKA--EEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKN----------- 605
            +++ +L+ K   LKA  E+EK N  + +  + K      E ++K+F++            
Sbjct: 1170 QQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEE----EELKKEFIEKEAKLHSEIKEK 1225

Query: 606  -----KLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLE 660
                 K  ++  K T  +   N  +  + +E +  + ++ +++   DDL     E   LE
Sbjct: 1226 EVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDL---RGEIAVLE 1282

Query: 661  RRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVD 720
                N +D+ + L +     + E+      EK +T   + L ++L    A    L RE  
Sbjct: 1283 ATVQNNQDERRALLERCLKGEGEI------EKLQTKVLE-LQRKLDNTTAAVQELGRENQ 1335

Query: 721  ALKEK 725
            +L+ K
Sbjct: 1336 SLQIK 1340



 Score = 95.5 bits (236), Expect = 3e-19
 Identities = 126/602 (20%), Positives = 253/602 (42%), Gaps = 73/602 (12%)

Query: 253 LTLQRQKIQELTTNAKE-----THTKLALAEAR-VQEEEQKATRLEKELQTQTTKFHQDQ 306
           +TL RQ++Q+L  + KE        K  L + + +Q++E K   L  +   +     Q  
Sbjct: 85  VTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQL 144

Query: 307 DTIMAKLTNEDSQNRQLQQKLAALSRQIDELE---ETNRSLRK-AEEELQDIKEKISKGE 362
           +    +  N        +QK A L+ +I +++   +  RSLR+ AE+++  + E+++K  
Sbjct: 145 EEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEA 204

Query: 363 YGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSK 422
                +  E+ + R  + D+    +EL++++    ++    ERE+ + KD          
Sbjct: 205 TVIQDLKTELLQ-RPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKD---------- 253

Query: 423 RIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKT 482
                +KL+  +  S+     L+  L K         QEL+ LK  + EL      L + 
Sbjct: 254 ---ECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTEN 310

Query: 483 EFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEE 542
               ++D TKL+         +K +   L + +   Q   S+L   +  +  +  +L E+
Sbjct: 311 LLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEK 370

Query: 543 ---TKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIE 599
              T++  +  ++VE K   +  E   L+ + + +E+ G  L S +N L ++L   E   
Sbjct: 371 GEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETE--- 427

Query: 600 KDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETL 659
                 +L +  G+        + K+ +  Q+V  L+LKL  ++             E L
Sbjct: 428 -----RQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLE-------------EQL 469

Query: 660 ERRYANERDKAQFLSK-ELEHVKMELAKYKLAEKTETSHE--QWLFKRLQEEEAKSGHLS 716
           + +  N  +    L K + +H + +  +     K   +    + + +++ +++ K  +L 
Sbjct: 470 KEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLE 529

Query: 717 REVDALKEKIHEY-MATEDLICHLQ---GDHSVLQKKLNQQENRNRDLGREIENLTKELE 772
             +   KE I       EDL   +Q   G+ +V    LNQ + +N  L  ++  LT++L+
Sbjct: 530 ALLQKSKENISLLEKEREDLYAKIQAGEGETAV----LNQLQEKNHTLQEQVTQLTEKLK 585

Query: 773 RYRHFSKSLRPSLNGRRISDPQVFSKEVQTEAVDNEPPDYKSLIPLERAV--INGQLYEE 830
                 K  + +L+       QV  ++    A  +       ++ LE +V  +N QL E 
Sbjct: 586 NQSESHKQAQENLH------DQVQEQKAHLRAAQDR------VLSLETSVNELNSQLNES 633

Query: 831 SE 832
            E
Sbjct: 634 KE 635



 Score = 78.6 bits (192), Expect = 3e-14
 Identities = 105/507 (20%), Positives = 227/507 (44%), Gaps = 33/507 (6%)

Query: 93   LKAEKMDLALLEAQYGFVTPK--KVLEALQ--RDAFQAKSTPWQEDIY--EKPMNELDKV 146
            L+  KM+   L  +   V  K  KV ++L+  +  F+ ++   +  I   EK   EL   
Sbjct: 841  LQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQ 900

Query: 147  VEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICLLEQECERLKKL 206
            ++   E+  +   +L  + +  ++   +L+ E    +E + ++   +   E+E ++L+  
Sbjct: 901  LQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGN 960

Query: 207  IDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTN 266
            I++  +S E+K+++ E     LK  + +       +  +  +   +L  +++KI  L  N
Sbjct: 961  INELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNN 1020

Query: 267  AKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQK 326
             +++       ++     E +     ++L++   K    Q+ +++      +QN+ +Q+ 
Sbjct: 1021 YEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQEL 1080

Query: 327  LAALSRQIDELEETNRSLRKAEEELQDIKEKISKGE---YGNAGIMAEVEELRKRVLDME 383
              A +    +  +  + L++  + LQDI+++ S  E         +AE+EE++ R     
Sbjct: 1081 KTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCR----- 1135

Query: 384  GKDEELIKMEEQCRDLNKRLERETLQSKDFK--LEVEKLSKRIMALEKLEDAFNKSKQEC 441
             +++E+ K+ E+ +       +E    KD K  L  +KL  +  A + L+ A  + K+  
Sbjct: 1136 -QEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKA-DSLKAAVEQEKRNQ 1193

Query: 442  YSLKCNLEKERMTTKQLSQELES-LKVRIKELEAIESRLEKTEFTLKEDLTKLK----TL 496
              LK  ++KE    K+   E E+ L   IKE E    + E+ E  L   +T L     T+
Sbjct: 1194 QILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTV 1253

Query: 497  TVMFVDERKTMSEKLKKTED---KLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDV 553
               +   ++ +SE  K+T+D   ++    + +Q  Q++   + E       R LK + ++
Sbjct: 1254 KKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLE-------RCLKGEGEI 1306

Query: 554  EEKMYSVTKERDDLKNKLKAEEEKGND 580
            E+    V + +  L N   A +E G +
Sbjct: 1307 EKLQTKVLELQRKLDNTTAAVQELGRE 1333



 Score = 70.9 bits (172), Expect = 7e-12
 Identities = 92/452 (20%), Positives = 184/452 (40%), Gaps = 79/452 (17%)

Query: 385 KDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEK--------------LSKRIMALEKL 430
           K +++  + ++ +DL   L+ E   S++ K E+EK              ++     L+ L
Sbjct: 81  KRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSL 140

Query: 431 EDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLE---------- 480
           E    +++ E +++K   +       QL+ E+  +K +  E  ++    E          
Sbjct: 141 EQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEEL 200

Query: 481 ----------KTEF----------TLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQ- 519
                     KTE            LK++L +++TL      ER+  SEKLK    KLQ 
Sbjct: 201 NKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQS 260

Query: 520 ------AASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVT-----KERDDLK 568
                 A  SQL+ E  K        ++E ++   S  ++ +K  ++T     KE+D   
Sbjct: 261 QYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQD--- 317

Query: 569 NKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKEL 628
              K EE+   + +S+ N+     Q      KD    +L      S T+LH+ + ++ E 
Sbjct: 318 -YTKLEEKHNEESVSKKNIQATLHQ------KDLDCQQLQSRLSASETSLHRIHVELSEK 370

Query: 629 SQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMEL---- 684
            +  ++LK   +++  +E      + E++ L+++   +      L  E+  +  +L    
Sbjct: 371 GEATQKLK---EELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETE 427

Query: 685 -----AKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHL 739
                A  +L E+ + S E+ + K  Q  + +   LSR  + LKEK+      +  +   
Sbjct: 428 RQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQL-KLSRLEEQLKEKVTNSTELQHQLDKT 486

Query: 740 QGDHSVLQKKLNQQENRNRDLGREIENLTKEL 771
           +  H   Q        + R+   ++E + +++
Sbjct: 487 KQQHQEQQALQQSTTAKLREAQNDLEQVLRQI 518



 Score = 60.5 bits (145), Expect = 9e-09
 Identities = 90/418 (21%), Positives = 181/418 (43%), Gaps = 68/418 (16%)

Query: 428 EKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKE----LEAIESRLEKTE 483
           E + DA N S    +  + NL  +R     L QE++ L+  +KE     E ++  LEK +
Sbjct: 61  EAVHDAGNDSG---HGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQ 117

Query: 484 FTLKEDL----------TKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVT 533
              +++            +L++L    ++E +T +  +K+ +D  +  ++QL  E   + 
Sbjct: 118 GLQQQEAKPDGLVTDSSAELQSLEQQ-LEEAQTENFNIKQMKDLFEQKAAQLATE---IA 173

Query: 534 TVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSR-----VNML 588
            +  K  EE  R+L+     E     VT+  ++L  +    ++   +LL R     V +L
Sbjct: 174 DIKSKYDEE--RSLR-----EAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVL 226

Query: 589 KNRLQSLEAI----------EKDFLKN---KLNQDSGKSTTALHQENNKIKELSQEV--- 632
           K  L  ++ +          E + LK+   KL      S   + Q  +++ +  QEV   
Sbjct: 227 KKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVY 286

Query: 633 ----ERLKLKLKDM----KAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMEL 684
               ++LK  + ++    + + ++L+K E +Y  LE ++  E    + +   L    ++ 
Sbjct: 287 VQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDC 346

Query: 685 AKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHS 744
            +     ++  S  +    R+  E ++ G  +++   LKE++ E    E    HL+ +  
Sbjct: 347 QQL----QSRLSASETSLHRIHVELSEKGEATQK---LKEELSE---VETKYQHLKAEFK 396

Query: 745 VLQKKLNQQENRNRDLGREIENL-TKELERYRHFSKSLRPSLNGRRISDPQVFSKEVQ 801
            LQ++  ++E     L  EI  L +K LE  R   ++       R++S  ++  KE Q
Sbjct: 397 QLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQ 454


>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
            sapiens]
          Length = 1843

 Score =  122 bits (306), Expect = 2e-27
 Identities = 173/773 (22%), Positives = 333/773 (43%), Gaps = 99/773 (12%)

Query: 53   AEKPHSGNGHQAEDLSRDDLLFL------LSILEGELQAR-DEVIG----ILKAEKMDLA 101
            +E P    GH+  +L+   LL L      L+    EL+   D V G    ILK EK +  
Sbjct: 443  SEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQR 502

Query: 102  LLEAQYGFVTPKKVLEALQRDAFQAKSTPWQ-EDIYEKPMNE---LDKVVEKHKESYRRI 157
            L           K +E L+ +  Q K +    +++ +  M E   L+K +E  +E+  R 
Sbjct: 503  L----------SKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQ 552

Query: 158  LGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEK 217
            +  L    +   QT+  L +  +   E   K          + E+  K++ + IK    K
Sbjct: 553  IKILEQENEHLNQTVSSLRQRSQISAEARVK----------DIEKENKILHESIKETSSK 602

Query: 218  EQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALA 277
              + E     +K+EL   K       + +  L   L  + + +Q+  TN K T  K+   
Sbjct: 603  LSKIEFEKRQIKKELEHYKEKGERAEELENELH-HLEKENELLQKKITNLKITCEKIEAL 661

Query: 278  EARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDEL 337
            E    E E++  +L+K L +                       + L  +L +L ++  +L
Sbjct: 662  EQENSELERENRKLKKTLDSF----------------------KNLTFQLESLEKENSQL 699

Query: 338  EETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRK--RVLDMEGKDEELIKMEEQ 395
            +E N  LR+  E L+    K+++ +  N  + +E E+L+K   +L    K  E +++  Q
Sbjct: 700  DEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQ 759

Query: 396  CRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTT 455
              D+  +  ++TL++ + K  +++L   +  LE       K+ +E       LE+     
Sbjct: 760  GLDIENQRLQKTLENSNKK--IQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKEN 817

Query: 456  KQLSQELESLKVRIKELEAIESRL----EKTEFTLKEDLTKLKTLTVMFVDERKTMSE-- 509
            K L QE   L+   K+LE    RL    E  + TL+E+  K+  L      E KT+S+  
Sbjct: 818  KSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLE----KENKTLSKEI 873

Query: 510  --------KLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVT 561
                    +LK+ E + +    +  ++   + T+ E L+ E  +  +   D+E+  + + 
Sbjct: 874  GIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELE 933

Query: 562  KERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQE 621
            K   + K +L  +E+  +D  SR  +L+++L+S      +  + K+          L + 
Sbjct: 934  KIGLN-KERLLHDEQSTDD--SRYKLLESKLESTLKKSLEIKEEKI----AALEARLEES 986

Query: 622  NNKIKELSQEVERLKLKLKDMKAIEDD--LMKTEDEYETLERRYANERDKAQFLSKELEH 679
             N  ++L QE++ +K   + +K  +D+  ++++       + ++  E   +Q  ++EL  
Sbjct: 987  TNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERE---SQETTRELLK 1043

Query: 680  VKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEK---IHEYMAT-EDL 735
            VK  L + +    T  + +Q L  +L++ E ++ +L  ++ AL+ +   + E   T +  
Sbjct: 1044 VKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQ 1103

Query: 736  ICHLQGDHSVLQKKLNQQENRNRDL---GREIENLTKELERYRHFSKSLRPSL 785
               LQ ++S L  +     N+N  L      +EN  + + + R   KSL  SL
Sbjct: 1104 NAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSL 1156



 Score =  110 bits (274), Expect = 1e-23
 Identities = 156/716 (21%), Positives = 319/716 (44%), Gaps = 95/716 (13%)

Query: 133  EDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSR---RQTILELEEEKRKHKEYMEKS 189
            ED  E      DK+ E  KE+ + +  +L   E  R   R+ I EL EE    +   ++S
Sbjct: 364  EDQLEGTRARSDKLHELEKENLQ-LKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQS 422

Query: 190  DEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVD-EQQR 248
             +    L  E E++ +    E+    +K         +L  E+ +L S  L+ ++ E Q 
Sbjct: 423  MDESLHLGWELEQISR--TSELSEAPQK---------SLGHEVNELTSSRLLKLEMENQS 471

Query: 249  LTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDT 308
            LT  +   R  +  +  NA           +++ + E++  RL K+++    +  Q++ +
Sbjct: 472  LTKTVEELRTTVDSVEGNA-----------SKILKMEKENQRLSKKVEILENEIVQEKQS 520

Query: 309  IMAKLTNEDSQNRQLQQKLAALSRQIDEL-EETNRSLRKAEEELQDIKEKISKGEYGNAG 367
                L N  + ++ L ++ A L + I+ L E + R ++  E+E + + + +S      + 
Sbjct: 521  ----LQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQ-RSQ 575

Query: 368  IMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMAL 427
            I AE      RV D+E +++ L    E  ++ + +L +   + +  K E+E   ++    
Sbjct: 576  ISAEA-----RVKDIEKENKIL---HESIKETSSKLSKIEFEKRQIKKELEHYKEKGERA 627

Query: 428  EKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIE---SRLEKTEF 484
            E+LE+  +           +LEKE    + L +++ +LK+  +++EA+E   S LE+   
Sbjct: 628  EELENELH-----------HLEKE---NELLQKKITNLKITCEKIEALEQENSELERENR 673

Query: 485  TLKEDLTKLKTLTVMFVDERKTMSE------KLKKTEDKLQAAS---SQLQVEQNKVTTV 535
             LK+ L   K LT       K  S+      +L++  + L+ AS   +QLQ+E  ++ + 
Sbjct: 674  KLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESE 733

Query: 536  TEKL---IEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRL 592
             E+L   +E  K + K    +E     +  E   L+  L+   +K   L S +  L+   
Sbjct: 734  KEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMEN 793

Query: 593  QSLEA-IEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMK 651
            Q+L+  +E+  + +K  +   K   +L QE +++++  +++E+   +L+    I+D  ++
Sbjct: 794  QTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLE 853

Query: 652  --------TEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAE-------KTETS 696
                     E E +TL +     ++    L KELE    EL K    +       + +  
Sbjct: 854  ENNVKIGNLEKENKTLSKEIGIYKESCVRL-KELEKENKELVKRATIDIKTLVTLREDLV 912

Query: 697  HEQWLFKRLQEEEAKSGHLSREVDALKEK-IHEYMATEDLICHLQGDHSVLQKKLNQQEN 755
             E+   +++  +  K  H   ++   KE+ +H+  +T+D        + +L+ KL     
Sbjct: 913  SEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDD------SRYKLLESKLESTLK 966

Query: 756  RNRDLGRE-IENLTKELERYRHFSKSLRPSLNGRRISDPQVFSKEVQTEAVDNEPP 810
            ++ ++  E I  L   LE   ++++ LR  L   + +   +  ++ +   V + PP
Sbjct: 967  KSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPP 1022



 Score =  110 bits (274), Expect = 1e-23
 Identities = 162/753 (21%), Positives = 327/753 (43%), Gaps = 88/753 (11%)

Query: 61   GHQAEDLSRDDLLFLLSILEGELQARDEVIGILKAEKMDLALLEAQYGFVTP-----KKV 115
            G +AE+L  +     L  LE E +   + I  LK     +  LE +   +       KK 
Sbjct: 624  GERAEELENE-----LHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKT 678

Query: 116  LEALQRDAFQAKSTPWQEDIYEKPMNELDKVVEK-----HKESYRRILGQLLVAEKSRRQ 170
            L++ +   FQ +S   +    ++   EL + VE       K +  ++  + L +EK + +
Sbjct: 679  LDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLK 738

Query: 171  TILELEEEKRKHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKE 230
              LEL +   K  E +E S + + +  Q  ++  +  +++I+  E + Q+ E    TL++
Sbjct: 739  KGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQK 798

Query: 231  ELTKLK--SFALMVVDEQQRLTAQLTLQRQKIQ-ELTTNAKETHTKLALAEARVQEEEQK 287
             L +LK  S  L  ++++ +   Q T Q +K + +L    K    +  + +  ++E   K
Sbjct: 799  NLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVK 858

Query: 288  ATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKA 347
               LEKE +T + +    +++ + +L   + +N++L ++     + +  L E   S +  
Sbjct: 859  IGNLEKENKTLSKEIGIYKESCV-RLKELEKENKELVKRATIDIKTLVTLREDLVSEKLK 917

Query: 348  EEELQDIKEKISKGEYGNAGIMAE--------VEELRKRVLDMEGKDEELIKM-----EE 394
             +++ +  EK++  E    G+  E         ++ R ++L  E K E  +K      EE
Sbjct: 918  TQQMNNDLEKLTH-ELEKIGLNKERLLHDEQSTDDSRYKLL--ESKLESTLKKSLEIKEE 974

Query: 395  QCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMT 454
            +   L  RLE  T  ++  + E++ + K   AL++ +D   +  Q    +     K    
Sbjct: 975  KIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDE-ERMVQSSPPISGEDNKWERE 1033

Query: 455  TKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLT-----VMFVDERKTMSE 509
            +++ ++EL  +K R+ E+E   + L+  +  LK  L +L+T        +   +R+T+S 
Sbjct: 1034 SQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVS- 1092

Query: 510  KLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKN 569
             L++    LQ  +++LQVE + + + +  L+ +  + L  ++ +E +  SV KER+DLK+
Sbjct: 1093 -LQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKS 1151

Query: 570  KLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELS 629
                             +  + ++  E +E       L++       +L  ++  +K   
Sbjct: 1152 -----------------LYDSLIKDHEKLEL------LHERQASEYESLISKHGTLKSAH 1188

Query: 630  QEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAK--- 686
            + +E   ++ +D++   + L+K + + E LE+    E++K    +K  E V  E  K   
Sbjct: 1189 KNLE---VEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCG 1245

Query: 687  ------------YKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATED 734
                         K  E  +T H+  L   L   + +   L  E   LKE   +Y   + 
Sbjct: 1246 ENDRLNHTYSQLLKETEVLQTDHKN-LKSLLNNSKLEQTRLEAEFSKLKE---QYQQLDI 1301

Query: 735  LICHLQGDHSVLQKKLNQQENRNRDLGREIENL 767
                L     +L +     E  NR L  +I+ L
Sbjct: 1302 TSTKLNNQCELLSQLKGNLEEENRHLLDQIQTL 1334



 Score =  100 bits (248), Expect = 1e-20
 Identities = 165/707 (23%), Positives = 312/707 (44%), Gaps = 98/707 (13%)

Query: 184 EYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVV 243
           ++ME +D    + +++ E L K +   +K   ++  E  + +  L EE   L  F     
Sbjct: 174 QWMEVTD----MSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLH-FLPHAS 228

Query: 244 DEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFH 303
              Q       ++R + ++        H  + LA+A+      K  RL +EL+ +T +  
Sbjct: 229 SSAQSPCGSPGMKRTESRQ--------HLSVELADAKA-----KIRRLRQELEEKTEQ-- 273

Query: 304 QDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEY 363
                    L +   +  Q++ +L  L ++   L    RS R   +EL  ++EK  + + 
Sbjct: 274 ---------LLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDK 324

Query: 364 GNAGI------MAEVEELRKRVLDMEGKDEELIK----MEEQCRDLNKR------LERET 407
             + +      + ++E  + RV +++  ++ L++    +E+Q      R      LE+E 
Sbjct: 325 LESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKEN 384

Query: 408 LQSK----DFKLEVEKLSKRIMALEK----LEDAFNKSKQECYSLKCNLEKERMTTKQLS 459
           LQ K    D ++E +   K+I  L +    LE A  +S  E   L   LE+   T++   
Sbjct: 385 LQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSE 444

Query: 460 QELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQ 519
              +SL   + EL +  SRL K E    + LTK        VD  +  + K+ K E + Q
Sbjct: 445 APQKSLGHEVNELTS--SRLLKLEME-NQSLTKTVEELRTTVDSVEGNASKILKMEKENQ 501

Query: 520 AASSQLQVEQNKVTTVTEKL---IEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEE 576
             S ++++ +N++    + L      +K  +K K  +E+ + ++   R++ + ++K  E+
Sbjct: 502 RLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETL---RENSERQIKILEQ 558

Query: 577 KGNDLLSRVNMLKNRLQ-SLEAIEKDFLK-NKLNQDSGKSTTA-LHQENNKIKELSQEVE 633
           +   L   V+ L+ R Q S EA  KD  K NK+  +S K T++ L +   + +++ +E+E
Sbjct: 559 ENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELE 618

Query: 634 RLKLKLKDMKAIEDDLMKTEDEYETLERRYANER---DKAQFLSKELEHVKMELAKYKLA 690
             K K +  + +E++L   E E E L+++  N +   +K + L +E   ++ E  K K  
Sbjct: 619 HYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLK-- 676

Query: 691 EKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKL 750
            KT  S +   F +L+  E ++  L  E   L+  +      E L C           K+
Sbjct: 677 -KTLDSFKNLTF-QLESLEKENSQLDEENLELRRNV------ESLKC--------ASMKM 720

Query: 751 NQQENRNRDLGREIENLTKELERYR-HFSKS--LRPSLNGRRISDPQVFS---------K 798
            Q +  N++L  E E L K LE  +  F K+  L  S  G  I + ++           +
Sbjct: 721 AQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ 780

Query: 799 EVQTEAVDNEPPDYKSLIPLERAVINGQLYEESENQDEDPNDEGSVL 845
           ++++E  D E  +      LE   I+ +  E+ E +++    E S L
Sbjct: 781 QLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQL 827



 Score = 84.0 bits (206), Expect = 8e-16
 Identities = 144/578 (24%), Positives = 248/578 (42%), Gaps = 94/578 (16%)

Query: 54   EKPHSGNGHQAE--DLSRDDLLFLLSILEGELQARDEVIGILKAEKMDLALLEAQYGFVT 111
            EK +     QAE  D + ++    +  LE E +   + IGI K   + L  LE +   + 
Sbjct: 835  EKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELV 894

Query: 112  PK-----KVLEALQRDAFQAK-STPWQEDIYEKPMNELDKV----------VEKHKESYR 155
             +     K L  L+ D    K  T    +  EK  +EL+K+           +   +S  
Sbjct: 895  KRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRY 954

Query: 156  RILGQLLVAEKSRRQTILELEEEKRKHKEY-MEKSDEFICLLEQEC-------ERLKKLI 207
            ++L   L   +S  +  LE++EEK    E  +E+S  +   L QE        E LK+  
Sbjct: 955  KLLESKL---ESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQ 1011

Query: 208  DQEIKSQ-------EEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKI 260
            D+E   Q       E+ + E+E + TT   EL K+K   + V      L A+    + ++
Sbjct: 1012 DEERMVQSSPPISGEDNKWERESQETT--RELLKVKDRLIEVERNNATLQAEKQALKTQL 1069

Query: 261  QELTTNAKETHTK-LALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQ 319
            ++L T       + LAL    V  +EQ  T     LQTQ  K   +  T+ ++ T+  +Q
Sbjct: 1070 KQLETQNNNLQAQILALQRQTVSLQEQNTT-----LQTQNAKLQVENSTLNSQSTSLMNQ 1124

Query: 320  NRQLQQKLAALS-------RQIDELEETNRSLRKAEEELQDIKEK--------ISK-GEY 363
            N QL  + ++L        ++ ++L+    SL K  E+L+ + E+        ISK G  
Sbjct: 1125 NAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTL 1184

Query: 364  GNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKR 423
             +A    EVE       D+E +  +L+K + Q  DL K L          K+E EK+   
Sbjct: 1185 KSAHKNLEVEH-----RDLEDRYNQLLKQKGQLEDLEKML----------KVEQEKM--- 1226

Query: 424  IMALEKLEDAFNKSKQECYSLKCNLEKERM--TTKQLSQELESLKVRIKELEAI--ESRL 479
                  LE+  +++    Y   C  E +R+  T  QL +E E L+   K L+++   S+L
Sbjct: 1227 -----LLENKNHETVAAEYKKLCG-ENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKL 1280

Query: 480  EKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKL 539
            E+T   L+ + +KLK        +    S KL    + L      L+ E   +    + L
Sbjct: 1281 EQTR--LEAEFSKLKEQ----YQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTL 1334

Query: 540  IEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEK 577
            + + +  L+   + ++  +   ++  D  N+L+ ++EK
Sbjct: 1335 MLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEK 1372



 Score = 42.4 bits (98), Expect = 0.003
 Identities = 58/248 (23%), Positives = 97/248 (39%), Gaps = 59/248 (23%)

Query: 133  EDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEF 192
            E ++E+  +E + ++ KH        G L  A K+       LE E R      +  D +
Sbjct: 1164 ELLHERQASEYESLISKH--------GTLKSAHKN-------LEVEHR------DLEDRY 1202

Query: 193  ICLLEQ--ECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLT 250
              LL+Q  + E L+K++    K ++EK   + K   T+  E  KL         E  RL 
Sbjct: 1203 NQLLKQKGQLEDLEKML----KVEQEKMLLENKNHETVAAEYKKL-------CGENDRLN 1251

Query: 251  ---AQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQD 307
               +QL  + + +Q    N K       L + R++ E  K     ++L   +TK +   +
Sbjct: 1252 HTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCE 1311

Query: 308  TIMAKLTNEDSQNRQLQQKLAALSRQ----------------------IDELEETNRSLR 345
             +     N + +NR L  ++  L  Q                      ID+L E  R   
Sbjct: 1312 LLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKE 1371

Query: 346  KAEEELQD 353
            K EE++ D
Sbjct: 1372 KLEEKIMD 1379


>gi|58530840 desmoplakin isoform I [Homo sapiens]
          Length = 2871

 Score =  120 bits (302), Expect = 6e-27
 Identities = 148/718 (20%), Positives = 313/718 (43%), Gaps = 88/718 (12%)

Query: 169  RQTILELEEEKRKHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTL 228
            +Q + +  E+  +HK+ +E++ + I    +E ERLK    +E K + E E E  K     
Sbjct: 1296 KQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNY 1355

Query: 229  KEELTKLKSFALMVVDEQQRLTAQLTLQ--------RQKIQELTTNAKETHTKLALAEAR 280
             EE+  LK+     ++  +    QLT+Q        R +I  LT   +    ++   +  
Sbjct: 1356 DEEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNT 1415

Query: 281  VQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEET 340
            + +  +   R+E+++Q Q        +    K   E    +  Q +     R    L++ 
Sbjct: 1416 LTQTTENLRRVEEDIQQQKA---TGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDA 1472

Query: 341  NRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDME----GKDEELIKMEEQC 396
             ++++   +E++ +K+ I K       +  E   L++   D++       E + K++ Q 
Sbjct: 1473 AKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQE 1532

Query: 397  RDLNK-RLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTT 455
            ++L + R++ E + S++  ++ + +++   +L++L+    K ++E   LK    ++    
Sbjct: 1533 QELTRLRIDYERV-SQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKR 1591

Query: 456  KQLSQELESLKVRIKE----LEAIESRLEKTEFTLK---EDLTKLKTLTVMFVDERKTMS 508
            K+L +ELE ++  +KE    +  +  +LE+     K   +DL + + +    + E++   
Sbjct: 1592 KKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQ 1651

Query: 509  EKLKKTEDKLQAASSQLQVEQNKVTTV------TEKLIEETKRAL-KSKTDV-------- 553
            E+L++   +++A   QL  EQ  V          +K IE+  R+L +SK ++        
Sbjct: 1652 EELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTE 1711

Query: 554  ---------EEKMYSVTKERDDL-KNKLKAEEEKGNDLL---SRVNMLKNRLQSLEAIEK 600
                     EE++ ++  E DDL + + +A+ +K   +L   S++ +  NR   L+ +  
Sbjct: 1712 NLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLIN 1771

Query: 601  DFLK---------NKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMK 651
            D  +          K  + + +++  + +  N+  ++ QE E L +K+K ++  +  L +
Sbjct: 1772 DLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQR 1831

Query: 652  TEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAK 711
             EDE    +     E    Q L  E + ++ +L ++    KT+ S ++   ++++ E  K
Sbjct: 1832 LEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQW----KTQYSRKEEAIRKIESEREK 1887

Query: 712  SGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKEL 771
            S    RE ++L+ +I                   LQ ++ + E R R   R++E+ T+E 
Sbjct: 1888 S---EREKNSLRSEIER-----------------LQAEIKRIEERCR---RKLEDSTRET 1924

Query: 772  ERYRHFSKSLRPSLNGRRISDPQVFSKEVQTEAVDNEPPDYKSLIPLERAVINGQLYE 829
            +      +S       +    P    +E QTE              L + V   QLYE
Sbjct: 1925 QSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLYE 1982



 Score =  109 bits (273), Expect = 1e-23
 Identities = 124/546 (22%), Positives = 249/546 (45%), Gaps = 82/546 (15%)

Query: 164  AEKSRRQTILELE---------EEKRKHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQ 214
            +E S+R+  LE+E         EE  ++K+ ++ + + I    +E ERLK+LID+E   +
Sbjct: 1438 SEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDR 1497

Query: 215  EEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKL 274
            +  E E   R+  ++ +L K  S            +A  T+ + K+QE      +  T+L
Sbjct: 1498 KCLEDE-NARLQRVQYDLQKANS------------SATETINKLKVQE------QELTRL 1538

Query: 275  ALAEARVQEE----EQKATRLE---KELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKL 327
             +   RV +E    +Q  TR +   KELQ Q  K  ++ + +    + +  + ++L+++L
Sbjct: 1539 RIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEEL 1598

Query: 328  AALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDE 387
              + R + E      +L +  E+   +K++          +  + + L   + + +   E
Sbjct: 1599 EGMRRSLKEQAIKITNLTQQLEQASIVKKR------SEDDLRQQRDVLDGHLREKQRTQE 1652

Query: 388  ELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSK---QECYSL 444
            EL ++  +   L ++L +E    K   L  E   K   A+E    + N+SK   +   SL
Sbjct: 1653 ELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQK---AIEDKSRSLNESKIEIERLQSL 1709

Query: 445  KCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEK----TEFTLKEDL-------TKL 493
              NL KE +    L +EL +L++   +L    S  +     T   L+  L        +L
Sbjct: 1710 TENLTKEHL---MLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLEL 1766

Query: 494  KTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTE---------KLIEETK 544
            + L      ER+ + ++++K + +   AS+++Q  +N+ T V +         K++E+ K
Sbjct: 1767 QGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDK 1826

Query: 545  RALKSKTDVEEKMYSVTKERDDLKNKLKAEEEK-GNDLLSRVNMLKNRLQSLEAIEKDFL 603
              L+   D   +  S  +    +K +L+ E+++  NDL         + +++  IE +  
Sbjct: 1827 ARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESERE 1886

Query: 604  KNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRY 663
            K++  ++S +S         +I+ L  E++R++ + +  + +ED   +T+ + ET   RY
Sbjct: 1887 KSEREKNSLRS---------EIERLQAEIKRIEERCR--RKLEDSTRETQSQLETERSRY 1935

Query: 664  ANERDK 669
              E DK
Sbjct: 1936 QREIDK 1941



 Score =  108 bits (271), Expect = 2e-23
 Identities = 145/673 (21%), Positives = 288/673 (42%), Gaps = 87/673 (12%)

Query: 101  ALLEAQYGFVTPKKVLEALQRDAFQAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQ 160
            +L EA        K +E L+ +  +     W+   YE   NEL KV   + E    +  Q
Sbjct: 1312 SLEEAAKTIQDKNKEIERLKAEFQEEAKRRWE---YE---NELSKVRNNYDEEIISLKNQ 1365

Query: 161  ----LLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICLLEQECERLKKLIDQEIKS--- 213
                + + + +  Q  ++ EE+   ++  ++        L +E +RLK  + Q  ++   
Sbjct: 1366 FETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRR 1425

Query: 214  -QEEKEQEKE--KRVTTLKEEL-TKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNA-- 267
             +E+ +Q+K     V+  K++L  +L+    M  +E  R    L    + IQ+       
Sbjct: 1426 VEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIER 1485

Query: 268  ------KETHTKLALAE-----ARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNE 316
                  KET+ +  L +      RVQ + QKA       +T      Q+Q+    ++  E
Sbjct: 1486 LKQLIDKETNDRKCLEDENARLQRVQYDLQKAN--SSATETINKLKVQEQELTRLRIDYE 1543

Query: 317  D-SQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEEL 375
              SQ R ++ +   ++R  + L+E     +K EEEL  +K   S+       +  E+E +
Sbjct: 1544 RVSQERTVKDQ--DITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGM 1601

Query: 376  RKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFN 435
            R+ + +   K   L +  EQ   + KR E +  Q +D       L   +   ++ ++   
Sbjct: 1602 RRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDV------LDGHLREKQRTQEELR 1655

Query: 436  KSKQECYSLKCNLEKERMTTKQL--------------SQELESLKVRIKELEAIESRLEK 481
            +   E  +L+  L +E+ + KQ               S+ L   K+ I+ L+++   L K
Sbjct: 1656 RLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTK 1715

Query: 482  TEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIE 541
                L+E+   L+ L + + D R+  SE        +    SQLQ+  N+ T   + LI 
Sbjct: 1716 EHLMLEEE---LRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNR-TLELQGLIN 1771

Query: 542  ETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNR-LQSLEAIEK 600
            + +R                 ER++L+ +++  +++  +  +R+   KN+  Q ++  E 
Sbjct: 1772 DLQR-----------------ERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERES 1814

Query: 601  DFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLK-DMKAIEDDLMKTEDEYETL 659
              +K K+ +        L  E N+ K   +   R+K +L+ + + I++DL + + +Y   
Sbjct: 1815 LLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRK 1874

Query: 660  E---RRYANERDKAQ----FLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKS 712
            E   R+  +ER+K++     L  E+E ++ E+   ++ E+     E    +   + E + 
Sbjct: 1875 EEAIRKIESEREKSEREKNSLRSEIERLQAEIK--RIEERCRRKLEDSTRETQSQLETER 1932

Query: 713  GHLSREVDALKEK 725
                RE+D L+++
Sbjct: 1933 SRYQREIDKLRQR 1945



 Score = 73.9 bits (180), Expect = 8e-13
 Identities = 133/668 (19%), Positives = 278/668 (41%), Gaps = 84/668 (12%)

Query: 145  KVVEKHKESYRRILGQLLVAEKSRRQTILE-------------LEEEKRKHKEYMEKSDE 191
            K +  ++++Y+     L  A+  RRQ  LE             L E+K  H E   K D+
Sbjct: 886  KQLRNYRDNYQAFCKWLYDAK--RRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDK 943

Query: 192  FICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKE---ELTKLKSFALMVVDEQQR 248
                  +E +++ +L    IK  E +       + TL     + T ++S + +++ E   
Sbjct: 944  -----SEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAAD 998

Query: 249  LTAQ----LTLQRQKIQELTTNAKETHT-KLALAEARVQEEEQKATRLEKELQTQTTKFH 303
            + A+    LT      + L+   K     KL   +  V EEE    RL ++  ++    +
Sbjct: 999  VHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEE---LRLARDANSENCNKN 1055

Query: 304  QDQDTIMAKLTNEDSQNRQLQQKLAALSRQID-ELEETNRSLRKAEEELQDIKEKISKGE 362
            +  D  + K   E SQ +     L  L RQ + + +   ++L K   +++++ EKI++  
Sbjct: 1056 KFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLT 1115

Query: 363  YGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSK 422
            Y       E+E+ ++R   +E + ++     +Q +   ++ E+E L  +  KLE EK   
Sbjct: 1116 Y-------EIEDEKRRRKSVEDRFDQQKNDYDQLQKA-RQCEKENLGWQ--KLESEK--- 1162

Query: 423  RIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKT 482
                      A  + + E   L+  L++E   T++   E E  KVR    E + +   K 
Sbjct: 1163 ----------AIKEKEYEIERLRVLLQEEG--TRKREYENELAKVRNHYNEEMSNLRNKY 1210

Query: 483  EFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEE 542
            E  +    T +K +++   D+ K +  +L +   + +    ++    + +   TE+    
Sbjct: 1211 ETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRA 1270

Query: 543  TKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKG----NDLLSRVNMLKNRLQSLEAI 598
             + AL+ K    E M        +LK  ++   E        L      ++++ + +E +
Sbjct: 1271 EENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERL 1330

Query: 599  EKDFLKNKLNQDSGKSTTALHQENNKIK-ELSQEVERLKLKLKDMKAIEDDLMKTEDEYE 657
            + +F      Q+  K       E +K++    +E+    + LK+    E ++ KT     
Sbjct: 1331 KAEF------QEEAKRRWEYENELSKVRNNYDEEI----ISLKNQFETEINITKTTIHQL 1380

Query: 658  TLERRYANERDKAQF--LSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHL 715
            T+++       +AQ   L++E   +  E+ + K      T + + + + +Q+++A    +
Sbjct: 1381 TMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEV 1440

Query: 716  SREVDALKEKIHE--YMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELER 773
            S+    L+ ++ +   M TE+ + + Q         L+      +D  +EIE L + +++
Sbjct: 1441 SQRKQQLEVELRQVTQMRTEESVRYKQ--------SLDDAAKTIQDKNKEIERLKQLIDK 1492

Query: 774  YRHFSKSL 781
              +  K L
Sbjct: 1493 ETNDRKCL 1500



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 103/557 (18%), Positives = 208/557 (37%), Gaps = 119/557 (21%)

Query: 333  QIDELEETNRSLRKAEEELQDIKEKIS--KGEYGNAGIMAEVEELRKRVLDMEGKDE--- 387
            +I+EL+      +   E L  +K+ ++  +G      +  EV  L +++ ++ G  +   
Sbjct: 705  KINELKSVQNDSQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYL 764

Query: 388  -------ELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQE 440
                    L++   Q  D+ K  E    + +   L+++K+      L+K+++  N  K  
Sbjct: 765  NSLCTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSL 824

Query: 441  CYSLKCNLEKERMTTKQLSQE--------------------------------LESLKVR 468
              ++K  L+K +    Q SQ+                                L  L+ +
Sbjct: 825  LATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQ 884

Query: 469  IKELEAIESRLE---KTEFTLKEDLTKLKTL------TVM-FVDERKTMSEKLKKTEDKL 518
            IK+L       +   K  +  K     L+++      TVM F++E+K +  ++    DK 
Sbjct: 885  IKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKS 944

Query: 519  QAASSQLQVEQNKVTTVTEKLIEET-----------KRA---------LKSKTDVEEK-- 556
            +      ++  N +     +L   T           KR          L+   DV  +  
Sbjct: 945  EEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYI 1004

Query: 557  ------------MYSVTKERDDLKNK----------LKAEEEKGNDLLSRVNMLKNRLQS 594
                        +  + K  +DLK K          L+   +  ++  ++   L   LQ 
Sbjct: 1005 ELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQK 1064

Query: 595  LEAIEKDF---------LKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKD---- 641
             +A    F         LK +   D   +   L +   +IKEL++++ RL  +++D    
Sbjct: 1065 YQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRR 1124

Query: 642  MKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWL 701
             K++ED   + +++Y+ L++    E++   +   E E    E  +Y++        E+  
Sbjct: 1125 RKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKE-KEYEIERLRVLLQEEGT 1183

Query: 702  FKRLQEEEAKS--GHLSREVDALKEKIHEYM-----ATEDLICHLQGDHSVLQKKLNQQE 754
             KR  E E      H + E+  L+ K    +       +++    + D   L+ +L++  
Sbjct: 1184 RKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLS 1243

Query: 755  NRNRDLGREIENLTKEL 771
              NRDL  EI  L   +
Sbjct: 1244 RENRDLKDEIVRLNDSI 1260


>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
            sapiens]
          Length = 1870

 Score =  120 bits (301), Expect = 7e-27
 Identities = 171/773 (22%), Positives = 330/773 (42%), Gaps = 100/773 (12%)

Query: 53   AEKPHSGNGHQAEDLSRDDLLFL------LSILEGELQAR-DEVIG----ILKAEKMDLA 101
            +E P    GH+  +L+   LL L      L+    EL+   D V G    ILK EK +  
Sbjct: 443  SEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQR 502

Query: 102  LLEAQYGFVTPKKVLEALQRDAFQAKSTPWQ-EDIYEKPMNE---LDKVVEKHKESYRRI 157
            L           K +E L+ +  Q K +    +++ +  M E   L+K +E  +E+  R 
Sbjct: 503  L----------SKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQ 552

Query: 158  LGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEK 217
            +  L    +   QT+  L +  +   E   K          + E+  K++ + IK    K
Sbjct: 553  IKILEQENEHLNQTVSSLRQRSQISAEARVK----------DIEKENKILHESIKETSSK 602

Query: 218  EQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALA 277
              + E     +K+EL   K       + +  L   L  + + +Q+  TN K T  K+   
Sbjct: 603  LSKIEFEKRQIKKELEHYKEKGERAEELENELH-HLEKENELLQKKITNLKITCEKIEAL 661

Query: 278  EARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDEL 337
            E    E E++  +L+K L +                       + L  +L +L ++  +L
Sbjct: 662  EQENSELERENRKLKKTLDSF----------------------KNLTFQLESLEKENSQL 699

Query: 338  EETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRK--RVLDMEGKDEELIKMEEQ 395
            +E N  LR+  E L+    K+++ +  N  + +E E+L+K   +L    K  E +++  Q
Sbjct: 700  DEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQ 759

Query: 396  CRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTT 455
              D+  +  ++TL++ + K  +++L   +  LE       K+ +E       LE+     
Sbjct: 760  GLDIENQRLQKTLENSNKK--IQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKEN 817

Query: 456  KQLSQELESLKVRIKELEAIESRL----EKTEFTLKEDLTKLKTLTVMFVDERKTMSE-- 509
            K L QE   L+   K+LE    RL    E  + TL+E+  K+  L      E KT+S+  
Sbjct: 818  KSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLE----KENKTLSKEI 873

Query: 510  --------KLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVT 561
                    +LK+ E + +    +  ++   + T+ E L+ E  +  +   D+E+  + + 
Sbjct: 874  GIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHEL- 932

Query: 562  KERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQE 621
             E+  L  +    +E+  D   R  +L+++L+S      +  + K+          L + 
Sbjct: 933  -EKIGLNKERLLHDEQSTD--DRYKLLESKLESTLKKSLEIKEEKI----AALEARLEES 985

Query: 622  NNKIKELSQEVERLKLKLKDMKAIEDD--LMKTEDEYETLERRYANERDKAQFLSKELEH 679
             N  ++L QE++ +K   + +K  +D+  ++++       + ++  E   +Q  ++EL  
Sbjct: 986  TNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERE---SQETTRELLK 1042

Query: 680  VKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEK---IHEYMAT-EDL 735
            VK  L + +    T  + +Q L  +L++ E ++ +L  ++ AL+ +   + E   T +  
Sbjct: 1043 VKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQ 1102

Query: 736  ICHLQGDHSVLQKKLNQQENRNRDL---GREIENLTKELERYRHFSKSLRPSL 785
               LQ ++S L  +     N+N  L      +EN  + + + R   KSL  SL
Sbjct: 1103 NAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSL 1155



 Score =  112 bits (280), Expect = 2e-24
 Identities = 157/749 (20%), Positives = 323/749 (43%), Gaps = 81/749 (10%)

Query: 61   GHQAEDLSRDDLLFLLSILEGELQARDEVIGILKAEKMDLALLEAQYGFVTP-----KKV 115
            G +AE+L  +     L  LE E +   + I  LK     +  LE +   +       KK 
Sbjct: 624  GERAEELENE-----LHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKT 678

Query: 116  LEALQRDAFQAKSTPWQEDIYEKPMNELDKVVEK-----HKESYRRILGQLLVAEKSRRQ 170
            L++ +   FQ +S   +    ++   EL + VE       K +  ++  + L +EK + +
Sbjct: 679  LDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLK 738

Query: 171  TILELEEEKRKHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKE 230
              LEL +   K  E +E S + + +  Q  ++  +  +++I+  E + Q+ E    TL++
Sbjct: 739  KGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQK 798

Query: 231  ELTKLK--SFALMVVDEQQRLTAQLTLQRQKIQ-ELTTNAKETHTKLALAEARVQEEEQK 287
             L +LK  S  L  ++++ +   Q T Q +K + +L    K    +  + +  ++E   K
Sbjct: 799  NLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVK 858

Query: 288  ATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQK----LAALSRQIDELEETNRS 343
               LEKE +T + +    +++ + +L   + +N++L ++    +  L    ++L      
Sbjct: 859  IGNLEKENKTLSKEIGIYKESCV-RLKELEKENKELVKRATIDIKTLVTLREDLVSEKLK 917

Query: 344  LRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKM-----EEQCRD 398
             ++   +L+ +  ++ K       ++ + +    R   +E K E  +K      EE+   
Sbjct: 918  TQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAA 977

Query: 399  LNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQL 458
            L  RLE  T  ++  + E++ + K   AL++ +D   +  Q    +     K    +++ 
Sbjct: 978  LEARLEESTNYNQQLRQELKTVKKNYEALKQRQDE-ERMVQSSPPISGEDNKWERESQET 1036

Query: 459  SQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLT-----VMFVDERKTMSEKLKK 513
            ++EL  +K R+ E+E   + L+  +  LK  L +L+T        +   +R+T+S  L++
Sbjct: 1037 TRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVS--LQE 1094

Query: 514  TEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKA 573
                LQ  +++LQVE + + + +  L+ +  + L  ++ +E +  SV KER+DLK+    
Sbjct: 1095 QNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKS---- 1150

Query: 574  EEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVE 633
                         +  + ++  E +E       L++       +L  ++  +K   + +E
Sbjct: 1151 -------------LYDSLIKDHEKLEL------LHERQASEYESLISKHGTLKSAHKNLE 1191

Query: 634  RLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAK------- 686
               ++ +D++   + L+K + + E LE+    E++K    +K  E V  E  K       
Sbjct: 1192 ---VEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDR 1248

Query: 687  --------YKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICH 738
                     K  E  +T H+  L   L   + +   L  E   LKE   +Y   +     
Sbjct: 1249 LNHTYSQLLKETEVLQTDHKN-LKSLLNNSKLEQTRLEAEFSKLKE---QYQQLDITSTK 1304

Query: 739  LQGDHSVLQKKLNQQENRNRDLGREIENL 767
            L     +L +     E  NR L  +I+ L
Sbjct: 1305 LNNQCELLSQLKGNLEEENRHLLDQIQTL 1333



 Score =  110 bits (275), Expect = 8e-24
 Identities = 156/713 (21%), Positives = 320/713 (44%), Gaps = 90/713 (12%)

Query: 133  EDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSR---RQTILELEEEKRKHKEYMEKS 189
            ED  E      DK+ E  KE+ + +  +L   E  R   R+ I EL EE    +   ++S
Sbjct: 364  EDQLEGTRARSDKLHELEKENLQ-LKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQS 422

Query: 190  DEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVD-EQQR 248
             +    L  E E++ +    E+    +K         +L  E+ +L S  L+ ++ E Q 
Sbjct: 423  MDESLHLGWELEQISR--TSELSEAPQK---------SLGHEVNELTSSRLLKLEMENQS 471

Query: 249  LTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDT 308
            LT  +   R  +  +  NA           +++ + E++  RL K+++    +  Q++ +
Sbjct: 472  LTKTVEELRTTVDSVEGNA-----------SKILKMEKENQRLSKKVEILENEIVQEKQS 520

Query: 309  IMAKLTNEDSQNRQLQQKLAALSRQIDEL-EETNRSLRKAEEELQDIKEKISKGEYGNAG 367
                L N  + ++ L ++ A L + I+ L E + R ++  E+E + + + +S      + 
Sbjct: 521  ----LQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQ-RSQ 575

Query: 368  IMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMAL 427
            I AE      RV D+E +++ L    E  ++ + +L +   + +  K E+E   ++    
Sbjct: 576  ISAEA-----RVKDIEKENKIL---HESIKETSSKLSKIEFEKRQIKKELEHYKEKGERA 627

Query: 428  EKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIE---SRLEKTEF 484
            E+LE+  +           +LEKE    + L +++ +LK+  +++EA+E   S LE+   
Sbjct: 628  EELENELH-----------HLEKE---NELLQKKITNLKITCEKIEALEQENSELERENR 673

Query: 485  TLKEDLTKLKTLTVMFVDERKTMSE------KLKKTEDKLQAAS---SQLQVEQNKVTTV 535
             LK+ L   K LT       K  S+      +L++  + L+ AS   +QLQ+E  ++ + 
Sbjct: 674  KLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESE 733

Query: 536  TEKL---IEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRL 592
             E+L   +E  K + K    +E     +  E   L+  L+   +K   L S +  L+   
Sbjct: 734  KEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMEN 793

Query: 593  QSLEA-IEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMK 651
            Q+L+  +E+  + +K  +   K   +L QE +++++  +++E+   +L+    I+D  ++
Sbjct: 794  QTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLE 853

Query: 652  --------TEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAE-KTETSHEQWLF 702
                     E E +TL +     ++    L KELE    EL K    + KT  +    L 
Sbjct: 854  ENNVKIGNLEKENKTLSKEIGIYKESCVRL-KELEKENKELVKRATIDIKTLVT----LR 908

Query: 703  KRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICH----LQGDHSVLQKKLNQQENRNR 758
            + L  E+ K+  ++ +++ L  ++ +    ++ + H        + +L+ KL     ++ 
Sbjct: 909  EDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSL 968

Query: 759  DLGRE-IENLTKELERYRHFSKSLRPSLNGRRISDPQVFSKEVQTEAVDNEPP 810
            ++  E I  L   LE   ++++ LR  L   + +   +  ++ +   V + PP
Sbjct: 969  EIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPP 1021



 Score =  100 bits (248), Expect = 1e-20
 Identities = 165/707 (23%), Positives = 312/707 (44%), Gaps = 98/707 (13%)

Query: 184 EYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVV 243
           ++ME +D    + +++ E L K +   +K   ++  E  + +  L EE   L  F     
Sbjct: 174 QWMEVTD----MSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLH-FLPHAS 228

Query: 244 DEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFH 303
              Q       ++R + ++        H  + LA+A+      K  RL +EL+ +T +  
Sbjct: 229 SSAQSPCGSPGMKRTESRQ--------HLSVELADAKA-----KIRRLRQELEEKTEQ-- 273

Query: 304 QDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEY 363
                    L +   +  Q++ +L  L ++   L    RS R   +EL  ++EK  + + 
Sbjct: 274 ---------LLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDK 324

Query: 364 GNAGI------MAEVEELRKRVLDMEGKDEELIK----MEEQCRDLNKR------LERET 407
             + +      + ++E  + RV +++  ++ L++    +E+Q      R      LE+E 
Sbjct: 325 LESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKEN 384

Query: 408 LQSK----DFKLEVEKLSKRIMALEK----LEDAFNKSKQECYSLKCNLEKERMTTKQLS 459
           LQ K    D ++E +   K+I  L +    LE A  +S  E   L   LE+   T++   
Sbjct: 385 LQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSE 444

Query: 460 QELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQ 519
              +SL   + EL +  SRL K E    + LTK        VD  +  + K+ K E + Q
Sbjct: 445 APQKSLGHEVNELTS--SRLLKLEME-NQSLTKTVEELRTTVDSVEGNASKILKMEKENQ 501

Query: 520 AASSQLQVEQNKVTTVTEKL---IEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEE 576
             S ++++ +N++    + L      +K  +K K  +E+ + ++   R++ + ++K  E+
Sbjct: 502 RLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETL---RENSERQIKILEQ 558

Query: 577 KGNDLLSRVNMLKNRLQ-SLEAIEKDFLK-NKLNQDSGKSTTA-LHQENNKIKELSQEVE 633
           +   L   V+ L+ R Q S EA  KD  K NK+  +S K T++ L +   + +++ +E+E
Sbjct: 559 ENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELE 618

Query: 634 RLKLKLKDMKAIEDDLMKTEDEYETLERRYANER---DKAQFLSKELEHVKMELAKYKLA 690
             K K +  + +E++L   E E E L+++  N +   +K + L +E   ++ E  K K  
Sbjct: 619 HYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLK-- 676

Query: 691 EKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKL 750
            KT  S +   F +L+  E ++  L  E   L+  +      E L C           K+
Sbjct: 677 -KTLDSFKNLTF-QLESLEKENSQLDEENLELRRNV------ESLKC--------ASMKM 720

Query: 751 NQQENRNRDLGREIENLTKELERYR-HFSKS--LRPSLNGRRISDPQVFS---------K 798
            Q +  N++L  E E L K LE  +  F K+  L  S  G  I + ++           +
Sbjct: 721 AQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ 780

Query: 799 EVQTEAVDNEPPDYKSLIPLERAVINGQLYEESENQDEDPNDEGSVL 845
           ++++E  D E  +      LE   I+ +  E+ E +++    E S L
Sbjct: 781 QLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQL 827



 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 146/574 (25%), Positives = 250/574 (43%), Gaps = 87/574 (15%)

Query: 54   EKPHSGNGHQAE--DLSRDDLLFLLSILEGELQARDEVIGILKAEKMDLALLEAQYGFVT 111
            EK +     QAE  D + ++    +  LE E +   + IGI K   + L  LE +   + 
Sbjct: 835  EKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELV 894

Query: 112  PK-----KVLEALQRDAFQAK-STPWQEDIYEKPMNELDKV-VEK----HKESYRRILGQ 160
             +     K L  L+ D    K  T    +  EK  +EL+K+ + K    H E       +
Sbjct: 895  KRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYK 954

Query: 161  LLVAE-KSRRQTILELEEEKRKHKEY-MEKSDEFICLLEQEC-------ERLKKLIDQEI 211
            LL ++ +S  +  LE++EEK    E  +E+S  +   L QE        E LK+  D+E 
Sbjct: 955  LLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEER 1014

Query: 212  KSQ-------EEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELT 264
              Q       E+ + E+E + TT   EL K+K   + V      L A+    + ++++L 
Sbjct: 1015 MVQSSPPISGEDNKWERESQETT--RELLKVKDRLIEVERNNATLQAEKQALKTQLKQLE 1072

Query: 265  TNAKETHTK-LALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQL 323
            T       + LAL    V  +EQ  T     LQTQ  K   +  T+ ++ T+  +QN QL
Sbjct: 1073 TQNNNLQAQILALQRQTVSLQEQNTT-----LQTQNAKLQVENSTLNSQSTSLMNQNAQL 1127

Query: 324  QQKLAALS-------RQIDELEETNRSLRKAEEELQDIKEK--------ISK-GEYGNAG 367
              + ++L        ++ ++L+    SL K  E+L+ + E+        ISK G   +A 
Sbjct: 1128 LIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAH 1187

Query: 368  IMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMAL 427
               EVE       D+E +  +L+K + Q  DL K L          K+E EK+       
Sbjct: 1188 KNLEVEH-----RDLEDRYNQLLKQKGQLEDLEKML----------KVEQEKM------- 1225

Query: 428  EKLEDAFNKSKQECYSLKCNLEKERM--TTKQLSQELESLKVRIKELEAI--ESRLEKTE 483
              LE+  +++    Y   C  E +R+  T  QL +E E L+   K L+++   S+LE+T 
Sbjct: 1226 -LLENKNHETVAAEYKKLCG-ENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTR 1283

Query: 484  FTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEET 543
              L+ + +KLK        +    S KL    + L      L+ E   +    + L+ + 
Sbjct: 1284 --LEAEFSKLKEQ----YQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQN 1337

Query: 544  KRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEK 577
            +  L+   + ++  +   ++  D  N+L+ ++EK
Sbjct: 1338 RTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEK 1371



 Score = 42.4 bits (98), Expect = 0.003
 Identities = 58/248 (23%), Positives = 97/248 (39%), Gaps = 59/248 (23%)

Query: 133  EDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEF 192
            E ++E+  +E + ++ KH        G L  A K+       LE E R      +  D +
Sbjct: 1163 ELLHERQASEYESLISKH--------GTLKSAHKN-------LEVEHR------DLEDRY 1201

Query: 193  ICLLEQ--ECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLT 250
              LL+Q  + E L+K++    K ++EK   + K   T+  E  KL         E  RL 
Sbjct: 1202 NQLLKQKGQLEDLEKML----KVEQEKMLLENKNHETVAAEYKKL-------CGENDRLN 1250

Query: 251  ---AQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQD 307
               +QL  + + +Q    N K       L + R++ E  K     ++L   +TK +   +
Sbjct: 1251 HTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCE 1310

Query: 308  TIMAKLTNEDSQNRQLQQKLAALSRQ----------------------IDELEETNRSLR 345
             +     N + +NR L  ++  L  Q                      ID+L E  R   
Sbjct: 1311 LLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKE 1370

Query: 346  KAEEELQD 353
            K EE++ D
Sbjct: 1371 KLEEKIMD 1378


>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 750

 Score =  119 bits (298), Expect = 2e-26
 Identities = 142/683 (20%), Positives = 311/683 (45%), Gaps = 60/683 (8%)

Query: 54  EKPHSGNGHQAEDLSRDDLLFLLSILEGELQARDEVIGILKAEKMDLALLEAQYGFVTPK 113
           E   SG  H  ED  +         L  EL+A+   I IL  +K +L +  A Y      
Sbjct: 97  ETTTSGGCHSPEDEQKASHQHQ-EALRRELEAQVHTIRILTCQKTELQM--ALYYSQHAV 153

Query: 114 KVLEALQRDAFQAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTIL 173
           K LE   RD        W+   +   + +    V   K+   R + +L    K R    L
Sbjct: 154 KQLEGEARDLISRLHDSWK---FAGELEQALSAVATQKKKADRYIEELT---KERDALSL 207

Query: 174 ELEEEKRKHKEYMEKS---DEFICLLEQECERLKKLIDQEIKSQEEK------EQEKEKR 224
           EL       +E  EK+    E + L+E E   ++  + +E+K + E+      +Q+ +  
Sbjct: 208 ELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNV-KELKRKLERAKLLLPQQQLQAE 266

Query: 225 VTTLKEELTKLKSFALMVVDEQQ---RLTAQ----LTLQRQKIQELTTNAKETHTKLALA 277
              L +EL  + +     V+E +   RL  Q    +  Q +KIQE     +E   K+   
Sbjct: 267 ADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQ 326

Query: 278 EARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDEL 337
           E +++E+E+K  R E+ +  +  K  + ++ +  K      Q   + +K   + RQ + +
Sbjct: 327 EEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMM 386

Query: 338 EETNRSLRKAEEELQDIKEKISKGE--YGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQ 395
            E    +R+ EE++ + +EKI + E        + E E+ +++   M  ++E++ + EE+
Sbjct: 387 WEKEEKIRELEEKMHE-QEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEK 445

Query: 396 CRDLNKRL--------ERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCN 447
            R+  K++        E+E ++ ++ + E E++ ++   + + E+ + + K++ +  +  
Sbjct: 446 IREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIW-RQKEKMHEQE-- 502

Query: 448 LEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTM 507
            EK R   +++ ++ E ++ + +++   E ++ + E  ++E     +    M   E+   
Sbjct: 503 -EKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWE 561

Query: 508 SEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDL 567
            EK ++ EDK+     +++ ++ KV    EK+ E+ ++    + + EEKM+   ++  + 
Sbjct: 562 EEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEK----RQEQEEKMWKQEEKIREQ 617

Query: 568 KNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKE 627
           + K++ +EE            K R Q  +  E++ +  +  +  G+    + ++  K++E
Sbjct: 618 EEKIQEQEE------------KIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQE 665

Query: 628 LSQEVERLKLKLKDM-KAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAK 686
             + + R + K+++  K I +   K  ++ E ++ +     ++ + + ++ E  KM+  +
Sbjct: 666 QEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEE--KMQEQE 723

Query: 687 YKLAEKTETSHEQWLFKRLQEEE 709
            K+  + E   EQ +  R QEE+
Sbjct: 724 EKMRRQEEKMWEQEVRLRQQEEK 746



 Score =  107 bits (267), Expect = 6e-23
 Identities = 140/687 (20%), Positives = 311/687 (45%), Gaps = 89/687 (12%)

Query: 145 KVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICLLEQECERLK 204
           K   +H+E+ RR L       +++  TI  L  +K + +  +  S   +  LE E   L 
Sbjct: 112 KASHQHQEALRREL-------EAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLI 164

Query: 205 KLIDQEIKSQEEKEQE------KEKRVTTLKEELTK------LKSFALMVVDEQ-----Q 247
             +    K   E EQ       ++K+     EELTK      L+ +   + DE+      
Sbjct: 165 SRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNA 224

Query: 248 RLTAQLTLQRQKIQELTTNAKETHTKLALAEARV--QEEEQKATRLEKELQTQTTKFHQD 305
           +L  +L L   +  E+  N KE   KL  A+  +  Q+ + +A  L KELQ+ + K    
Sbjct: 225 KLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAK---- 280

Query: 306 QDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYG- 364
              + A++   +  NR  QQ+   + RQ ++++E    +++ EE++++ +EKI + E   
Sbjct: 281 ---LQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKM 337

Query: 365 --NAGIMAEVEELRKRVLDMEG-KDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLS 421
                +M E EE  +R  +M   K+E++ + EE   +  +++ R+     + + ++ +L 
Sbjct: 338 RRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELE 397

Query: 422 KRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEK 481
           +++   EK+ +   K ++E        EK R   K+  QE +  +   K  E  E ++ +
Sbjct: 398 EKMHEQEKIREQEEKRQEE--------EKIREQEKRQEQEAKMWRQEEKIREQ-EEKIRE 448

Query: 482 TEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIE 541
            E  +     K+     +  +E++   E++ + E+K+         EQ ++    EK+ E
Sbjct: 449 QEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIH--------EQEEIWRQKEKMHE 500

Query: 542 ETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEK---GNDLLSRVNMLKNRLQSLEAI 598
           + ++  K     EEK++   ++  + + K++ +EEK     + +     +    + +   
Sbjct: 501 QEEKIRKQ----EEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQ 556

Query: 599 EKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYET 658
           EK + + K  +   K    + ++  KI+E  ++V R + K+++ +       K +++ E 
Sbjct: 557 EKIWEEEKRQEQEDK----MWRQEEKIREQEEKVWRQEEKIREQEE------KRQEQEEK 606

Query: 659 LERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSRE 718
           + ++    R++ + + ++ E ++ +  + K+ E+ E +         QE+E K G    +
Sbjct: 607 MWKQEEKIREQEEKIQEQEEKIREQ--EEKIREQEEMT---------QEQEEKMGEQEEK 655

Query: 719 VDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRD----LGREIENLTKELERY 774
           +   +EK+ E    E+ +   +      +KK+ +QE + R+    +  + E + ++ E+ 
Sbjct: 656 MCEQEEKMQEQ---EETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKM 712

Query: 775 RHFSKSLRPSLNGRRISDPQVFSKEVQ 801
               + ++      R  + +++ +EV+
Sbjct: 713 CEQEEKMQEQEEKMRRQEEKMWEQEVR 739



 Score =  107 bits (267), Expect = 6e-23
 Identities = 98/478 (20%), Positives = 228/478 (47%), Gaps = 44/478 (9%)

Query: 125 QAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKE 184
           + K   W+E I E+         EK +E   +I  Q    EK RRQ  +  E+E++    
Sbjct: 306 EEKIQEWEEKIQEQE--------EKIREQEEKIREQ---EEKMRRQEEMMWEKEEK---- 350

Query: 185 YMEKSDEFICLLEQECERLKKLI---DQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALM 241
            M + +E +   E++  R ++++   +++++ QEE   EKE+++  L+E++ +       
Sbjct: 351 -MRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHE------- 402

Query: 242 VVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTK 301
              E+ R   +   + +KI+E     +E   K+   E +++E+E+K    EK++  Q  K
Sbjct: 403 --QEKIREQEEKRQEEEKIRE-QEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEK 459

Query: 302 FHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKG 361
            H+ +          + + RQ Q+++     +I E EE  R   K  E+ + I+++  K 
Sbjct: 460 IHEQEKI-------REEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKV 512

Query: 362 EYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLS 421
                 I  + E++R++   M  ++E++ + EE  R+  K  E+E +  ++ + E E   
Sbjct: 513 WRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQE--D 570

Query: 422 KRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEK 481
           K     EK+ +   K  ++   ++   EK +   +++ ++ E ++ + ++++  E ++ +
Sbjct: 571 KMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIRE 630

Query: 482 TEFTLKEDLTKLKTLTVMFVDERKTM---SEKLKKTEDKLQAASSQLQVEQNKVTTVTEK 538
            E  ++E     +       ++ + M    EK+++ E+ +     +++ ++ K+    EK
Sbjct: 631 QEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEK 690

Query: 539 LIEETKRALKSKTDV---EEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQ 593
           + E+ +   + +  +   EEKM    ++  + + K++ +EEK  +   R+   + ++Q
Sbjct: 691 IREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQ 748



 Score = 64.3 bits (155), Expect = 6e-10
 Identities = 55/241 (22%), Positives = 122/241 (50%), Gaps = 34/241 (14%)

Query: 120 QRDAFQAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEK 179
           Q +  + +   W+E   E+ M+E +K+ E+ K   +         +K  RQ     EE+ 
Sbjct: 536 QEEKIREQEEMWRE---EEKMHEQEKIWEEEKRQEQE--------DKMWRQ-----EEKI 579

Query: 180 RKHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRV----TTLKEELTKL 235
           R+ +E + + +E I   EQE +R ++  ++++  QEEK +E+E+++      ++E+  K+
Sbjct: 580 REQEEKVWRQEEKI--REQEEKRQEQ--EEKMWKQEEKIREQEEKIQEQEEKIREQEEKI 635

Query: 236 KSFALMVVDEQQRLTAQ---LTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLE 292
           +    M  ++++++  Q   +  Q +K+QE          K+   E +++E+E+K    E
Sbjct: 636 REQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQE 695

Query: 293 KELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQ 352
           + +Q Q  K  + ++ +         Q  ++Q++   + RQ +++ E    LR+ EE++Q
Sbjct: 696 EMMQEQEEKMWEQEEKMC-------EQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQ 748

Query: 353 D 353
           +
Sbjct: 749 E 749


>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score =  119 bits (297), Expect = 2e-26
 Identities = 138/680 (20%), Positives = 302/680 (44%), Gaps = 91/680 (13%)

Query: 121  RDAFQAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKR 180
            R     K  PW +  ++  +  L K  E  KE              + ++   ++++E  
Sbjct: 825  RSFMNVKHWPWMKLFFK--IKPLLKSAETEKEM------------ATMKEEFQKIKDELA 870

Query: 181  KHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFAL 240
            K +   ++ +E +  L +E   L+  +  E +   + E+  ++ + T  +   K+K    
Sbjct: 871  KSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTE 930

Query: 241  MVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTT 300
               DE++ + A+LT +++K+++  +  K+    L L  A+V++E+       K L    T
Sbjct: 931  RAEDEEE-INAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNL----T 985

Query: 301  KFHQDQDTIMAKLTNEDSQNRQL-QQKLAALSRQIDELEETNRSLRKAEEELQDIKEKIS 359
            +     D  +AKLT E    ++  QQ L  L  + D++    ++  K E+++ D++  + 
Sbjct: 986  EEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLE 1045

Query: 360  KG-------EYGNAGIMAEVEELRKRVLDMEGK----DEELIKMEEQCRDLNKRLERETL 408
            +        E     +  +++  ++ ++D+E +    DE+L K E +  +L  ++E E  
Sbjct: 1046 QEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQA 1105

Query: 409  QSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELE----- 463
                 + ++++L  RI  LE+  +A   S+ +    + +L +E    +++S+ LE     
Sbjct: 1106 LGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRE---LEEISERLEEAGGA 1162

Query: 464  -SLKVRI---KELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQ 519
             S ++ +   +E E  + R +  E TL+ + T   TL     D    + E++    D LQ
Sbjct: 1163 TSAQIEMNKKREAEFQKMRRDLEEATLQHEAT-AATLRKKHADSVAELGEQI----DNLQ 1217

Query: 520  AASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGN 579
                +L+ E++++    + L    +   K+K ++E+    + +  +D  ++LK++EE+  
Sbjct: 1218 RVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEK----MCRTLEDQLSELKSKEEEQQ 1273

Query: 580  DLLSRVNMLKNRLQ------SLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVE 633
             L++ +   + RLQ      S +  EK+ L ++L++     T        +I+EL +++E
Sbjct: 1274 RLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFT-------QQIEELKRQLE 1326

Query: 634  RLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKT 693
                ++K   A+   L  +  + + L  +Y  E++    L + L     E+A+++     
Sbjct: 1327 E---EIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWR----- 1378

Query: 694  ETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQ 753
             T +E    +R +E E     L++ + A +E +                   +  K    
Sbjct: 1379 -TKYETDAIQRTEELEEAKKKLAQRLQAAEEHV-----------------EAVNAKCASL 1420

Query: 754  ENRNRDLGREIENLTKELER 773
            E   + L  E+E+L  ++ER
Sbjct: 1421 EKTKQRLQNEVEDLMLDVER 1440



 Score =  116 bits (290), Expect = 1e-25
 Identities = 176/846 (20%), Positives = 361/846 (42%), Gaps = 144/846 (17%)

Query: 82   ELQAR-DEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQRDAFQAKSTPWQEDIYEKPM 140
            ELQAR +E+   ++AE+   A  E Q   ++ +++ E  +R      +T  Q ++ +K  
Sbjct: 1116 ELQARIEELEEEIEAERASRAKAEKQRSDLS-RELEEISERLEEAGGATSAQIEMNKKRE 1174

Query: 141  NELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICLLEQEC 200
             E  K+    +E+  +         K    ++ EL E+    +   +K       LE+E 
Sbjct: 1175 AEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQK-------LEKEK 1227

Query: 201  ERLKKLIDQEIKSQEEKEQEK---EKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQR 257
              +K  ID    + E   + K   EK   TL+++L++LKS      +EQQRL   LT QR
Sbjct: 1228 SEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKE----EEQQRLINDLTAQR 1283

Query: 258  QKIQ-ELTTNAKETHTKLALA-------EARVQEEEQKATRLEKELQTQTTKFH------ 303
             ++Q E    +++   K AL        +A  Q+ E+   +LE+E++ +    H      
Sbjct: 1284 GRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSR 1343

Query: 304  QDQDTIMAKLTNEDSQNRQLQQKLAALSRQI---------------DELEETNRSLRK-- 346
             D D +  +   E     +LQ+ L+  + ++               +ELEE  + L +  
Sbjct: 1344 HDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRL 1403

Query: 347  --AEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLE 404
              AEE ++ +  K +  E     +  EVE+L   +LD+E  +     ++++ R+ +K L 
Sbjct: 1404 QAAEEHVEAVNAKCASLEKTKQRLQNEVEDL---MLDVERTNAACAALDKKQRNFDKILA 1460

Query: 405  RETLQSKDFKLEVEKLSKRIMALE----KLEDAFNKSKQECYSLKC---NLEKERMT-TK 456
                + ++   E+E   K   +L     K+++A+ +S  +  +LK    NL++E    T+
Sbjct: 1461 EWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTE 1520

Query: 457  QLSQ------ELESLKVRIKE--------LEAIESRLE----------------KTEFTL 486
            Q+++      ELE +K ++++        LE  E+ LE                K+E   
Sbjct: 1521 QIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDR 1580

Query: 487  K-----EDLTKLKTLTVMFVDE-RKTMSEKLKKTED------KLQAASSQLQVEQNKVTT 534
            K     E++ +LK   +  V+  + T+  +++   D      K++   ++++++ N    
Sbjct: 1581 KIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANR 1640

Query: 535  VTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQS 594
            +  + +   +       D +  +    + ++DLK +L   E + N L + +  L+  L+ 
Sbjct: 1641 MAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQ 1700

Query: 595  LEAIEKDFLKNKLNQDSGKSTTALHQENNKI----KELSQEVERLKLKLKDM-------- 642
             E   K   +  L  D+ +    LH +N  +    K+L  ++ +++ +++D+        
Sbjct: 1701 TERSRKIAEQELL--DASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAE 1758

Query: 643  ----KAIED------DLMKTEDEYETLERRYANER----------DKAQFLS-----KEL 677
                KAI D      +L K +D    LER   N            D+A+ L+     K++
Sbjct: 1759 EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQI 1818

Query: 678  EHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLIC 737
            + ++  + + +   ++E        K L++ E +   L+ + +  ++ I   +  +DL+ 
Sbjct: 1819 QKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNI---LRLQDLVD 1875

Query: 738  HLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPSLNGRRISDPQVFS 797
             LQ      +++  + E ++     +   L  ELE     +      +N  R+   +V +
Sbjct: 1876 KLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREVHT 1935

Query: 798  KEVQTE 803
            K +  E
Sbjct: 1936 KVISEE 1941



 Score =  112 bits (280), Expect = 2e-24
 Identities = 122/547 (22%), Positives = 255/547 (46%), Gaps = 73/547 (13%)

Query: 287  KATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRK 346
            K+   EKE+ T   +F + +D    +L   +++ ++L++K+  L ++ ++L+     ++ 
Sbjct: 847  KSAETEKEMATMKEEFQKIKD----ELAKSEAKRKELEEKMVTLLKEKNDLQ---LQVQA 899

Query: 347  AEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELI----KMEEQCRDLNK- 401
              E L D +E+  +       + A+++E+ +R  D E  + EL     K+E++C +L K 
Sbjct: 900  EAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKD 959

Query: 402  ---------RLERETLQS----KDFKLEVEKLSKRIMALEKLEDAFNKSKQECYS-LKCN 447
                     ++E+E   +    K+   E+  L + I  L K + A  ++ Q+    L+  
Sbjct: 960  IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAE 1019

Query: 448  LEKERMTTK---QLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVD-E 503
             +K    TK   +L Q+++ L+  +++ + +   LE+ +  L+ DL KL   ++M ++ E
Sbjct: 1020 EDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDL-KLAQESIMDIENE 1078

Query: 504  RKTMSEKLKKTEDKL----------QAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDV 553
            ++ + EKLKK E ++          QA   QLQ +  ++    E+L EE +    S+   
Sbjct: 1079 KQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKA 1138

Query: 554  EEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGK 613
            E++   +++E +++  +L   EE G    +++ M K R    + + +D L+    Q    
Sbjct: 1139 EKQRSDLSRELEEISERL---EEAGGATSAQIEMNKKREAEFQKMRRD-LEEATLQHEAT 1194

Query: 614  STTALHQENNKIKELSQEV---ERLKLKLK----DMKAIEDDLMKTEDEYETLERRYANE 666
            + T   +  + + EL +++   +R+K KL+    +MK   DDL       ET+ +   N 
Sbjct: 1195 AATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDL---ASNVETVSKAKGNL 1251

Query: 667  RDKAQFLSKELEHVK------MELAKYKLAEKTETSHEQWLFKR-LQEEEAKSGHLSR-- 717
                + L  +L  +K        L     A++     E   F R L E+EA    LSR  
Sbjct: 1252 EKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGK 1311

Query: 718  -----EVDALKEKIHEYMATEDLICHL----QGDHSVLQKKLNQQENRNRDLGREIENLT 768
                 +++ LK ++ E +  ++ + H     + D  +L+++  +++    +L R +    
Sbjct: 1312 QAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKAN 1371

Query: 769  KELERYR 775
             E+ ++R
Sbjct: 1372 TEVAQWR 1378



 Score =  102 bits (254), Expect = 2e-21
 Identities = 160/738 (21%), Positives = 323/738 (43%), Gaps = 105/738 (14%)

Query: 82   ELQARDEVIGILKAEKMDLALLEAQYGFVTP-KKVLE-ALQRDAFQAKSTPWQEDIYEKP 139
            +LQ + E  G+  AE+    L++ +       K+V E A   +   A+ T  +  + E  
Sbjct: 894  QLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKL-EDE 952

Query: 140  MNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICLLEQE 199
             +EL K ++  + +  ++       EK +  T    E + +   E M   DE I  L +E
Sbjct: 953  CSELKKDIDDLELTLAKV-------EKEKHAT----ENKVKNLTEEMAGLDETIAKLTKE 1001

Query: 200  CERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQK 259
                KK + +  +   +  Q +E +V TL +   KL+      VD+   L   L  +++ 
Sbjct: 1002 ----KKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQ----QVDD---LEGSLEQEKKL 1050

Query: 260  IQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQ 319
              +L    ++    L LA+  + + E +  +L+++L+ +  +       + +K+ +E + 
Sbjct: 1051 RMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEI----SNLQSKIEDEQAL 1106

Query: 320  NRQLQQKLAALSRQIDELEETNRSLR----KAEEELQDIKEKISKGEYGNAGIMAEVEEL 375
              QLQ+K+  L  +I+ELEE   + R    KAE++  D+                E+EE+
Sbjct: 1107 GIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSR--------------ELEEI 1152

Query: 376  RKRVLDMEGKDEELIKM----EEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLE 431
             +R+ +  G     I+M    E + + + + LE  TLQ +     + K  K   ++ +L 
Sbjct: 1153 SERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRK--KHADSVAELG 1210

Query: 432  DAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLT 491
            +  +  ++    +K  LEKE+    ++  E++ L   ++ +   +  LEK   TL++ L+
Sbjct: 1211 EQIDNLQR----VKQKLEKEK---SEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLS 1263

Query: 492  KLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKT 551
            +L           K+  E+ ++  + L A   +LQ E  + +   ++     K AL S+ 
Sbjct: 1264 EL-----------KSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDE-----KEALVSQL 1307

Query: 552  DVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSL--EAIEKDFLKNKLNQ 609
               ++ +  T++ ++LK +L+ E +  N L   +   ++    L  +  E+   K +L +
Sbjct: 1308 SRGKQAF--TQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQR 1365

Query: 610  DSGKSTTALHQENNKIK----ELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYAN 665
               K+ T + Q   K +    + ++E+E  K KL         L   E+  E +  + A+
Sbjct: 1366 ALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQR------LQAAEEHVEAVNAKCAS 1419

Query: 666  ERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEK 725
                 Q L  E+E + +++ +   A       ++   K L E + K      E++A  +K
Sbjct: 1420 LEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEA-SQK 1478

Query: 726  IHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPSL 785
                + TE        + S+ Q +  ++EN+N  L +EI +LT+++              
Sbjct: 1479 EARSLGTELFKIKNAYEESLDQLETLKRENKN--LQQEISDLTEQIAE------------ 1524

Query: 786  NGRRISDPQVFSKEVQTE 803
             G+RI + +   K+V+ E
Sbjct: 1525 GGKRIHELEKIKKQVEQE 1542



 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 144/696 (20%), Positives = 293/696 (42%), Gaps = 110/696 (15%)

Query: 63   QAEDLSRDDLLFLLSILEGELQARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQRD 122
            Q E+L R         LE E++A++ +   L++ + D  LL  QY      K    LQR 
Sbjct: 1317 QIEELKRQ--------LEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKA--ELQRA 1366

Query: 123  AFQAKSTPWQEDIYEKPMNELDKV--VEKHKESYRRILGQLLVAEK----------SRRQ 170
              +A +    E    +   E D +   E+ +E+ +++  +L  AE+          S  +
Sbjct: 1367 LSKANT----EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEK 1422

Query: 171  TILELEEEKRKHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKE---KRVTT 227
            T   L+ E       +E+++     L+++     K++ +  +  EE   E E   K   +
Sbjct: 1423 TKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARS 1482

Query: 228  LKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQK 287
            L  EL K+K+     +D+ + L  +    +Q+I +LT        ++A    R+ E E  
Sbjct: 1483 LGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLT-------EQIAEGGKRIHELE-- 1533

Query: 288  ATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKA 347
              +++K+++ +  +     +   A L +E+ +  ++Q +L  +  ++D      R + + 
Sbjct: 1534 --KIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVD------RKIAEK 1585

Query: 348  EEELQDIKEK-ISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERE 406
            +EE+  +K   I   E   + + AE+      +   +  + +L +ME Q    N R+  E
Sbjct: 1586 DEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHAN-RMAAE 1644

Query: 407  TLQS--------KDFKLEVEKLSKRIMALEK----LEDAFNKSKQECYSLKCNLEKERMT 454
             L++        KD ++ ++   +    L++    +E   N  + E   L+  LE+   +
Sbjct: 1645 ALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERS 1704

Query: 455  TKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKT 514
             K   QEL     R++ L    + L  T+  L+ D+++++      + E +   EK KK 
Sbjct: 1705 RKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKA 1764

Query: 515  EDKLQAASSQLQVEQNKVTTV--TEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLK 572
                   + +L+ EQ+    +   +K +E+T + L+ + D  E++             LK
Sbjct: 1765 ITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQL------------ALK 1812

Query: 573  AEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEV 632
              +++   L +RV  L+  ++S         + K N ++ K    L +   ++KEL+ + 
Sbjct: 1813 GGKKQIQKLEARVRELEGEVES---------EQKRNAEAVK---GLRKHERRVKELTYQT 1860

Query: 633  ERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEK 692
            E  +  +  ++ + D L      Y    +R A E +         E     LAK++    
Sbjct: 1861 EEDRKNILRLQDLVDKLQAKVKSY----KRQAEEAE---------EQSNTNLAKFR---- 1903

Query: 693  TETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHE 728
             +  HE      L+E E ++     +V+ L+ K  E
Sbjct: 1904 -KLQHE------LEEAEERADIAESQVNKLRVKSRE 1932


>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score =  119 bits (297), Expect = 2e-26
 Identities = 138/680 (20%), Positives = 302/680 (44%), Gaps = 91/680 (13%)

Query: 121  RDAFQAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKR 180
            R     K  PW +  ++  +  L K  E  KE              + ++   ++++E  
Sbjct: 825  RSFMNVKHWPWMKLFFK--IKPLLKSAETEKEM------------ATMKEEFQKIKDELA 870

Query: 181  KHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFAL 240
            K +   ++ +E +  L +E   L+  +  E +   + E+  ++ + T  +   K+K    
Sbjct: 871  KSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTE 930

Query: 241  MVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTT 300
               DE++ + A+LT +++K+++  +  K+    L L  A+V++E+       K L    T
Sbjct: 931  RAEDEEE-INAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNL----T 985

Query: 301  KFHQDQDTIMAKLTNEDSQNRQL-QQKLAALSRQIDELEETNRSLRKAEEELQDIKEKIS 359
            +     D  +AKLT E    ++  QQ L  L  + D++    ++  K E+++ D++  + 
Sbjct: 986  EEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLE 1045

Query: 360  KG-------EYGNAGIMAEVEELRKRVLDMEGK----DEELIKMEEQCRDLNKRLERETL 408
            +        E     +  +++  ++ ++D+E +    DE+L K E +  +L  ++E E  
Sbjct: 1046 QEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQA 1105

Query: 409  QSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELE----- 463
                 + ++++L  RI  LE+  +A   S+ +    + +L +E    +++S+ LE     
Sbjct: 1106 LGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRE---LEEISERLEEAGGA 1162

Query: 464  -SLKVRI---KELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQ 519
             S ++ +   +E E  + R +  E TL+ + T   TL     D    + E++    D LQ
Sbjct: 1163 TSAQIEMNKKREAEFQKMRRDLEEATLQHEAT-AATLRKKHADSVAELGEQI----DNLQ 1217

Query: 520  AASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGN 579
                +L+ E++++    + L    +   K+K ++E+    + +  +D  ++LK++EE+  
Sbjct: 1218 RVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEK----MCRTLEDQLSELKSKEEEQQ 1273

Query: 580  DLLSRVNMLKNRLQ------SLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVE 633
             L++ +   + RLQ      S +  EK+ L ++L++     T        +I+EL +++E
Sbjct: 1274 RLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFT-------QQIEELKRQLE 1326

Query: 634  RLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKT 693
                ++K   A+   L  +  + + L  +Y  E++    L + L     E+A+++     
Sbjct: 1327 E---EIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWR----- 1378

Query: 694  ETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQ 753
             T +E    +R +E E     L++ + A +E +                   +  K    
Sbjct: 1379 -TKYETDAIQRTEELEEAKKKLAQRLQAAEEHV-----------------EAVNAKCASL 1420

Query: 754  ENRNRDLGREIENLTKELER 773
            E   + L  E+E+L  ++ER
Sbjct: 1421 EKTKQRLQNEVEDLMLDVER 1440



 Score =  116 bits (290), Expect = 1e-25
 Identities = 176/846 (20%), Positives = 361/846 (42%), Gaps = 144/846 (17%)

Query: 82   ELQAR-DEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQRDAFQAKSTPWQEDIYEKPM 140
            ELQAR +E+   ++AE+   A  E Q   ++ +++ E  +R      +T  Q ++ +K  
Sbjct: 1116 ELQARIEELEEEIEAERASRAKAEKQRSDLS-RELEEISERLEEAGGATSAQIEMNKKRE 1174

Query: 141  NELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICLLEQEC 200
             E  K+    +E+  +         K    ++ EL E+    +   +K       LE+E 
Sbjct: 1175 AEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQK-------LEKEK 1227

Query: 201  ERLKKLIDQEIKSQEEKEQEK---EKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQR 257
              +K  ID    + E   + K   EK   TL+++L++LKS      +EQQRL   LT QR
Sbjct: 1228 SEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKE----EEQQRLINDLTAQR 1283

Query: 258  QKIQ-ELTTNAKETHTKLALA-------EARVQEEEQKATRLEKELQTQTTKFH------ 303
             ++Q E    +++   K AL        +A  Q+ E+   +LE+E++ +    H      
Sbjct: 1284 GRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSR 1343

Query: 304  QDQDTIMAKLTNEDSQNRQLQQKLAALSRQI---------------DELEETNRSLRK-- 346
             D D +  +   E     +LQ+ L+  + ++               +ELEE  + L +  
Sbjct: 1344 HDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRL 1403

Query: 347  --AEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLE 404
              AEE ++ +  K +  E     +  EVE+L   +LD+E  +     ++++ R+ +K L 
Sbjct: 1404 QAAEEHVEAVNAKCASLEKTKQRLQNEVEDL---MLDVERTNAACAALDKKQRNFDKILA 1460

Query: 405  RETLQSKDFKLEVEKLSKRIMALE----KLEDAFNKSKQECYSLKC---NLEKERMT-TK 456
                + ++   E+E   K   +L     K+++A+ +S  +  +LK    NL++E    T+
Sbjct: 1461 EWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTE 1520

Query: 457  QLSQ------ELESLKVRIKE--------LEAIESRLE----------------KTEFTL 486
            Q+++      ELE +K ++++        LE  E+ LE                K+E   
Sbjct: 1521 QIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDR 1580

Query: 487  K-----EDLTKLKTLTVMFVDE-RKTMSEKLKKTED------KLQAASSQLQVEQNKVTT 534
            K     E++ +LK   +  V+  + T+  +++   D      K++   ++++++ N    
Sbjct: 1581 KIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANR 1640

Query: 535  VTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQS 594
            +  + +   +       D +  +    + ++DLK +L   E + N L + +  L+  L+ 
Sbjct: 1641 MAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQ 1700

Query: 595  LEAIEKDFLKNKLNQDSGKSTTALHQENNKI----KELSQEVERLKLKLKDM-------- 642
             E   K   +  L  D+ +    LH +N  +    K+L  ++ +++ +++D+        
Sbjct: 1701 TERSRKIAEQELL--DASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAE 1758

Query: 643  ----KAIED------DLMKTEDEYETLERRYANER----------DKAQFLS-----KEL 677
                KAI D      +L K +D    LER   N            D+A+ L+     K++
Sbjct: 1759 EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQI 1818

Query: 678  EHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLIC 737
            + ++  + + +   ++E        K L++ E +   L+ + +  ++ I   +  +DL+ 
Sbjct: 1819 QKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNI---LRLQDLVD 1875

Query: 738  HLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPSLNGRRISDPQVFS 797
             LQ      +++  + E ++     +   L  ELE     +      +N  R+   +V +
Sbjct: 1876 KLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREVHT 1935

Query: 798  KEVQTE 803
            K +  E
Sbjct: 1936 KVISEE 1941



 Score =  112 bits (280), Expect = 2e-24
 Identities = 122/547 (22%), Positives = 255/547 (46%), Gaps = 73/547 (13%)

Query: 287  KATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRK 346
            K+   EKE+ T   +F + +D    +L   +++ ++L++K+  L ++ ++L+     ++ 
Sbjct: 847  KSAETEKEMATMKEEFQKIKD----ELAKSEAKRKELEEKMVTLLKEKNDLQ---LQVQA 899

Query: 347  AEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELI----KMEEQCRDLNK- 401
              E L D +E+  +       + A+++E+ +R  D E  + EL     K+E++C +L K 
Sbjct: 900  EAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKD 959

Query: 402  ---------RLERETLQS----KDFKLEVEKLSKRIMALEKLEDAFNKSKQECYS-LKCN 447
                     ++E+E   +    K+   E+  L + I  L K + A  ++ Q+    L+  
Sbjct: 960  IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAE 1019

Query: 448  LEKERMTTK---QLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVD-E 503
             +K    TK   +L Q+++ L+  +++ + +   LE+ +  L+ DL KL   ++M ++ E
Sbjct: 1020 EDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDL-KLAQESIMDIENE 1078

Query: 504  RKTMSEKLKKTEDKL----------QAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDV 553
            ++ + EKLKK E ++          QA   QLQ +  ++    E+L EE +    S+   
Sbjct: 1079 KQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKA 1138

Query: 554  EEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGK 613
            E++   +++E +++  +L   EE G    +++ M K R    + + +D L+    Q    
Sbjct: 1139 EKQRSDLSRELEEISERL---EEAGGATSAQIEMNKKREAEFQKMRRD-LEEATLQHEAT 1194

Query: 614  STTALHQENNKIKELSQEV---ERLKLKLK----DMKAIEDDLMKTEDEYETLERRYANE 666
            + T   +  + + EL +++   +R+K KL+    +MK   DDL       ET+ +   N 
Sbjct: 1195 AATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDL---ASNVETVSKAKGNL 1251

Query: 667  RDKAQFLSKELEHVK------MELAKYKLAEKTETSHEQWLFKR-LQEEEAKSGHLSR-- 717
                + L  +L  +K        L     A++     E   F R L E+EA    LSR  
Sbjct: 1252 EKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGK 1311

Query: 718  -----EVDALKEKIHEYMATEDLICHL----QGDHSVLQKKLNQQENRNRDLGREIENLT 768
                 +++ LK ++ E +  ++ + H     + D  +L+++  +++    +L R +    
Sbjct: 1312 QAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKAN 1371

Query: 769  KELERYR 775
             E+ ++R
Sbjct: 1372 TEVAQWR 1378



 Score =  102 bits (254), Expect = 2e-21
 Identities = 160/738 (21%), Positives = 323/738 (43%), Gaps = 105/738 (14%)

Query: 82   ELQARDEVIGILKAEKMDLALLEAQYGFVTP-KKVLE-ALQRDAFQAKSTPWQEDIYEKP 139
            +LQ + E  G+  AE+    L++ +       K+V E A   +   A+ T  +  + E  
Sbjct: 894  QLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKL-EDE 952

Query: 140  MNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICLLEQE 199
             +EL K ++  + +  ++       EK +  T    E + +   E M   DE I  L +E
Sbjct: 953  CSELKKDIDDLELTLAKV-------EKEKHAT----ENKVKNLTEEMAGLDETIAKLTKE 1001

Query: 200  CERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQK 259
                KK + +  +   +  Q +E +V TL +   KL+      VD+   L   L  +++ 
Sbjct: 1002 ----KKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQ----QVDD---LEGSLEQEKKL 1050

Query: 260  IQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQ 319
              +L    ++    L LA+  + + E +  +L+++L+ +  +       + +K+ +E + 
Sbjct: 1051 RMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEI----SNLQSKIEDEQAL 1106

Query: 320  NRQLQQKLAALSRQIDELEETNRSLR----KAEEELQDIKEKISKGEYGNAGIMAEVEEL 375
              QLQ+K+  L  +I+ELEE   + R    KAE++  D+                E+EE+
Sbjct: 1107 GIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSR--------------ELEEI 1152

Query: 376  RKRVLDMEGKDEELIKM----EEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLE 431
             +R+ +  G     I+M    E + + + + LE  TLQ +     + K  K   ++ +L 
Sbjct: 1153 SERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRK--KHADSVAELG 1210

Query: 432  DAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLT 491
            +  +  ++    +K  LEKE+    ++  E++ L   ++ +   +  LEK   TL++ L+
Sbjct: 1211 EQIDNLQR----VKQKLEKEK---SEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLS 1263

Query: 492  KLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKT 551
            +L           K+  E+ ++  + L A   +LQ E  + +   ++     K AL S+ 
Sbjct: 1264 EL-----------KSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDE-----KEALVSQL 1307

Query: 552  DVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSL--EAIEKDFLKNKLNQ 609
               ++ +  T++ ++LK +L+ E +  N L   +   ++    L  +  E+   K +L +
Sbjct: 1308 SRGKQAF--TQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQR 1365

Query: 610  DSGKSTTALHQENNKIK----ELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYAN 665
               K+ T + Q   K +    + ++E+E  K KL         L   E+  E +  + A+
Sbjct: 1366 ALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQR------LQAAEEHVEAVNAKCAS 1419

Query: 666  ERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEK 725
                 Q L  E+E + +++ +   A       ++   K L E + K      E++A  +K
Sbjct: 1420 LEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEA-SQK 1478

Query: 726  IHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPSL 785
                + TE        + S+ Q +  ++EN+N  L +EI +LT+++              
Sbjct: 1479 EARSLGTELFKIKNAYEESLDQLETLKRENKN--LQQEISDLTEQIAE------------ 1524

Query: 786  NGRRISDPQVFSKEVQTE 803
             G+RI + +   K+V+ E
Sbjct: 1525 GGKRIHELEKIKKQVEQE 1542



 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 144/696 (20%), Positives = 293/696 (42%), Gaps = 110/696 (15%)

Query: 63   QAEDLSRDDLLFLLSILEGELQARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQRD 122
            Q E+L R         LE E++A++ +   L++ + D  LL  QY      K    LQR 
Sbjct: 1317 QIEELKRQ--------LEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKA--ELQRA 1366

Query: 123  AFQAKSTPWQEDIYEKPMNELDKV--VEKHKESYRRILGQLLVAEK----------SRRQ 170
              +A +    E    +   E D +   E+ +E+ +++  +L  AE+          S  +
Sbjct: 1367 LSKANT----EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEK 1422

Query: 171  TILELEEEKRKHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKE---KRVTT 227
            T   L+ E       +E+++     L+++     K++ +  +  EE   E E   K   +
Sbjct: 1423 TKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARS 1482

Query: 228  LKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQK 287
            L  EL K+K+     +D+ + L  +    +Q+I +LT        ++A    R+ E E  
Sbjct: 1483 LGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLT-------EQIAEGGKRIHELE-- 1533

Query: 288  ATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKA 347
              +++K+++ +  +     +   A L +E+ +  ++Q +L  +  ++D      R + + 
Sbjct: 1534 --KIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVD------RKIAEK 1585

Query: 348  EEELQDIKEK-ISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERE 406
            +EE+  +K   I   E   + + AE+      +   +  + +L +ME Q    N R+  E
Sbjct: 1586 DEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHAN-RMAAE 1644

Query: 407  TLQS--------KDFKLEVEKLSKRIMALEK----LEDAFNKSKQECYSLKCNLEKERMT 454
             L++        KD ++ ++   +    L++    +E   N  + E   L+  LE+   +
Sbjct: 1645 ALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERS 1704

Query: 455  TKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKT 514
             K   QEL     R++ L    + L  T+  L+ D+++++      + E +   EK KK 
Sbjct: 1705 RKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKA 1764

Query: 515  EDKLQAASSQLQVEQNKVTTV--TEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLK 572
                   + +L+ EQ+    +   +K +E+T + L+ + D  E++             LK
Sbjct: 1765 ITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQL------------ALK 1812

Query: 573  AEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEV 632
              +++   L +RV  L+  ++S         + K N ++ K    L +   ++KEL+ + 
Sbjct: 1813 GGKKQIQKLEARVRELEGEVES---------EQKRNAEAVK---GLRKHERRVKELTYQT 1860

Query: 633  ERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEK 692
            E  +  +  ++ + D L      Y    +R A E +         E     LAK++    
Sbjct: 1861 EEDRKNILRLQDLVDKLQAKVKSY----KRQAEEAE---------EQSNTNLAKFR---- 1903

Query: 693  TETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHE 728
             +  HE      L+E E ++     +V+ L+ K  E
Sbjct: 1904 -KLQHE------LEEAEERADIAESQVNKLRVKSRE 1932


>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
            sapiens]
          Length = 1939

 Score =  118 bits (295), Expect = 4e-26
 Identities = 126/593 (21%), Positives = 270/593 (45%), Gaps = 95/593 (16%)

Query: 217  KEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLAL 276
            K  E EK +  +KEE  K K        +++ L  ++    Q+  +L    +     LA 
Sbjct: 845  KSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALAD 904

Query: 277  AEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDE 336
            AE R  +  +   +LE +++ + T+  +D++ I A+LT   ++ R+L+ + + L + ID+
Sbjct: 905  AEERCDQLIKTKIQLEAKIK-EVTERAEDEEEINAELT---AKKRKLEDECSELKKDIDD 960

Query: 337  LEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQC 396
            LE T   L K E+E    + K+                 +    +M G DE + K+ ++ 
Sbjct: 961  LELT---LAKVEKEKHATENKV-----------------KNLTEEMAGLDETIAKLTKEK 1000

Query: 397  RDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTK 456
            + L +   ++TL   D ++E +K++    A  KLE       Q+   L+ +LE+E    K
Sbjct: 1001 KALQEA-HQQTLD--DLQMEEDKVNTLTKAKTKLE-------QQVDDLEGSLEQE----K 1046

Query: 457  QLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTED 516
            +L  +LE  K +                 L+ DL   +  T+   ++++ ++EKLKK E 
Sbjct: 1047 KLCMDLERAKRK-----------------LEGDLKLAQESTMDTENDKQQLNEKLKKKEF 1089

Query: 517  KL----------QAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDD 566
            ++          QA + QLQ +  ++    E+L EE +    S+   E++   +++E ++
Sbjct: 1090 EMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEE 1149

Query: 567  LKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDS---------GKSTTA 617
            +  +L   EE G    +++ M K R    + + +D  ++ L  ++           S   
Sbjct: 1150 ISERL---EEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAE 1206

Query: 618  LHQENNKIKELSQEVER----LKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFL 673
            L ++ + ++ + Q++E+    LK+++ D+ +  + + K +  +E + R   ++  + +  
Sbjct: 1207 LGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTK 1266

Query: 674  SKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSR-------EVDALKEKI 726
             +E + +  EL+  K    TE+       ++L E++A    LSR       +++ LK ++
Sbjct: 1267 EEEQQRLINELSAQKARLHTESGE---FSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQL 1323

Query: 727  HEYMATEDLICH----LQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYR 775
             E    +  + H     + D  +L+++  +++    +L R +     E+ ++R
Sbjct: 1324 EEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWR 1376



 Score =  114 bits (284), Expect = 7e-25
 Identities = 169/846 (19%), Positives = 356/846 (42%), Gaps = 144/846 (17%)

Query: 82   ELQAR-DEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQRDAFQAKSTPWQEDIYEKPM 140
            ELQAR +E+   ++AE+   A  E Q   ++ +++ E  +R      +T  Q ++ +K  
Sbjct: 1114 ELQARIEELEEEIEAERASRAKAEKQRSDLS-RELEEISERLEEAGGATSAQIEMNKKRE 1172

Query: 141  NELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICLLEQEC 200
             E  K+    +ES  +         K    ++ EL E+    +   +K       LE+E 
Sbjct: 1173 AEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQK-------LEKEK 1225

Query: 201  ERLKKLIDQEIKSQEEKEQEK---EKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQR 257
              LK  I+    + E   + K   EK   TL+++L+++K+      +EQQRL  +L+ Q+
Sbjct: 1226 SELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKE----EEQQRLINELSAQK 1281

Query: 258  QKIQ-ELTTNAKETHTKLALA-------EARVQEEEQKATRLEKELQTQTTKFH------ 303
             ++  E    +++   K A+        +A  Q+ E+   +LE+E + ++T  H      
Sbjct: 1282 ARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSAR 1341

Query: 304  QDQDTIMAKLTNEDSQNRQLQQKLAALSRQI---------------DELEETNRSLRK-- 346
             D D +  +   E     +LQ+ ++  + ++               +ELEE  + L +  
Sbjct: 1342 HDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRL 1401

Query: 347  --AEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLE 404
              AEE ++ +  K +  E     +  EVE+L   ++D+E  +   I ++++ R+ +K L 
Sbjct: 1402 QDAEEHVEAVNSKCASLEKTKQRLQNEVEDL---MIDVERSNAACIALDKKQRNFDKVLA 1458

Query: 405  RETLQSKDFKLEVEKLSKRIMALE----KLEDAFNKSKQECYSLKC---NLEKE------ 451
                + ++ + E+E   K   +L     K+++A+ +S     +LK    NL++E      
Sbjct: 1459 EWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTE 1518

Query: 452  ------------RMTTKQLSQELESLKVRIKELEA------------------IESRLEK 481
                            KQL  E   L+  ++E EA                  ++S +++
Sbjct: 1519 QIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDR 1578

Query: 482  TEFTLKEDLTKLKTLTVMFVDE-RKTMSEKLKKTED------KLQAASSQLQVEQNKVTT 534
                  E+L +LK   +  V+  + T+  +++   D      K++   ++++++ N    
Sbjct: 1579 KIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANR 1638

Query: 535  VTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQS 594
               + +   +       D +  +    + +DDLK +L   E + N + + V  L+  L+ 
Sbjct: 1639 QAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLER 1698

Query: 595  LEAIEKDFLKNKLNQDSGKSTTALHQENNKI----KELSQEVERLKLKLKDM-------- 642
             E   K   +  L  D+ +    LH +N  +    K+L  ++ +++ +++D+        
Sbjct: 1699 TERGRKMAEQELL--DASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAE 1756

Query: 643  ----KAIED------DLMKTEDEYETLERRYANER----------DKAQFLS-----KEL 677
                KAI D      +L K +D    LER   N            D+A+ L+     K++
Sbjct: 1757 EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQI 1816

Query: 678  EHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLIC 737
            + ++  + + +   ++E  H     K L++ E +   L+ + +  ++ I   +  +DL+ 
Sbjct: 1817 QKLEARVRELESEVESEQKHNVEAVKGLRKHERRVKELTYQTEEDRKNI---LRLQDLVD 1873

Query: 738  HLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPSLNGRRISDPQVFS 797
             LQ      +++  + E ++     +   L  ELE  +  +      +N  R+   +V +
Sbjct: 1874 KLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELEEAKERADIAESQVNKLRVKSREVHT 1933

Query: 798  KEVQTE 803
            K +  E
Sbjct: 1934 KVISEE 1939



 Score =  105 bits (261), Expect = 3e-22
 Identities = 153/761 (20%), Positives = 307/761 (40%), Gaps = 125/761 (16%)

Query: 116  LEALQRDAFQAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQ----- 170
            ++ L + A   K     ++ +EK   EL K   K KE   +++   L+ EK+  Q     
Sbjct: 840  IKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMV--TLMQEKNDLQLQVQA 897

Query: 171  -----------------TILELEEEKRKHKEYMEKSDEFIC-------LLEQECERLKKL 206
                             T ++LE + ++  E  E  +E           LE EC  LKK 
Sbjct: 898  EADALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKD 957

Query: 207  IDQEIKSQEEKEQEK---EKRVTTLKEELTKLKSFALMVVDEQQRLTA-------QLTLQ 256
            ID    +  + E+EK   E +V  L EE+  L      +  E++ L          L ++
Sbjct: 958  IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQME 1017

Query: 257  RQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEK----------------------- 293
              K+  LT    +   ++   E  +++E++    LE+                       
Sbjct: 1018 EDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDK 1077

Query: 294  -ELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQ 352
             +L  +  K   +   +  K+ +E +   QLQ+K+  L  +I+EL          EEE++
Sbjct: 1078 QQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEEL----------EEEIE 1127

Query: 353  DIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKM----EEQCRDLNKRLERETL 408
              +   +K E   + +  E+EE+ +R+ +  G     I+M    E + + + + LE  TL
Sbjct: 1128 AERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTL 1187

Query: 409  QSKDFKLEV-EKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKV 467
            Q +     + +K +  +  L +  D+  + KQ+       LEKE+    +L  E+  L  
Sbjct: 1188 QHEATAAALRKKHADSVAELGEQIDSLQRVKQK-------LEKEK---SELKMEINDLAS 1237

Query: 468  RIKELEAIESRLEKTEFTLKEDLTKLKT--------LTVMFVDERK--TMSEKLKKTEDK 517
             ++ +   ++  EK   TL++ L+++KT        +  +   + +  T S +  +  D+
Sbjct: 1238 NMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDE 1297

Query: 518  LQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEK 577
              A  SQL   +   T   E+L  + +   K+K+ +   + S   + D L+ + + E+E 
Sbjct: 1298 KDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEA 1357

Query: 578  GNDL---LSRVN------MLKNRLQSLEAIEK-DFLKNKLNQDSGKSTTALHQENNKIKE 627
              +L   +S+ N        K    +++  E+ +  K KL Q    +   +   N+K   
Sbjct: 1358 KAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCAS 1417

Query: 628  LSQEVERLKLKLKDMK-----------AIEDDLMKTEDEYETLERRYANERDKAQFLSKE 676
            L +  +RL+ +++D+            A++      +      +++Y   + + +   KE
Sbjct: 1418 LEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKE 1477

Query: 677  LEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLI 736
               +  EL K K A +    H + L +  +  + +   L+ ++    + IHE    +  +
Sbjct: 1478 SRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQL 1537

Query: 737  CH----LQGDHSVLQKKLNQQENRNRDLGREIENLTKELER 773
             H    LQ      +  L  +E +   +  E+  +  E++R
Sbjct: 1538 DHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDR 1578



 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 142/686 (20%), Positives = 294/686 (42%), Gaps = 91/686 (13%)

Query: 63   QAEDLSRDDLLFLLSILEGELQARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQRD 122
            Q E+L R         LE E +A+  +   L++ + D  LL  QY      K    LQR 
Sbjct: 1315 QIEELKRQ--------LEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKA--ELQRG 1364

Query: 123  AFQAKSTPWQEDIYEKPMNELDKV--VEKHKESYRRILGQLLVAEK----------SRRQ 170
              +A S    E    +   E D +   E+ +E+ +++  +L  AE+          S  +
Sbjct: 1365 MSKANS----EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEK 1420

Query: 171  TILELEEEKRKHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKE---KRVTT 227
            T   L+ E       +E+S+     L+++     K++ +  +  EE + E E   K   +
Sbjct: 1421 TKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRS 1480

Query: 228  LKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQK 287
            L  EL K+K+     +D  + L  +    +Q+I +LT        ++A     + E E  
Sbjct: 1481 LSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTE-------QIAEGGKHIHELE-- 1531

Query: 288  ATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKA 347
              +++K+L  + ++     +   A L +E+ +  ++Q +L  +  +ID      R + + 
Sbjct: 1532 --KVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEID------RKIAEK 1583

Query: 348  EEELQDIKEK-ISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERE 406
            +EEL  +K   +   E   + + AE+      +   +  + +L +ME Q    N++   E
Sbjct: 1584 DEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAA-E 1642

Query: 407  TLQS--------KDFKLEVEKLSKRIMALEK----LEDAFNKSKQECYSLKCNLEKERMT 454
             L++        KD +L ++   +    L++    +E   N  + E   L+ +LE+    
Sbjct: 1643 ALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLERTERG 1702

Query: 455  TKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKT 514
             K   QEL     R++ L    + L  T+  L+ D+++++      V E +   EK KK 
Sbjct: 1703 RKMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKA 1762

Query: 515  EDKLQAASSQLQVEQNKVTTV--TEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLK 572
                   + +L+ EQ+    +   +K +E+T + L+ + D  E++             LK
Sbjct: 1763 ITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQL------------ALK 1810

Query: 573  AEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEV 632
              +++   L +RV  L++ ++S         + K N ++ K    L +   ++KEL+ + 
Sbjct: 1811 GGKKQIQKLEARVRELESEVES---------EQKHNVEAVK---GLRKHERRVKELTYQT 1858

Query: 633  ERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEK 692
            E  +   K++  ++D + K + + +  +R+     +++     +   ++ EL + K  E+
Sbjct: 1859 EEDR---KNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELEEAK--ER 1913

Query: 693  TETSHEQWLFKRLQEEEAKSGHLSRE 718
             + +  Q    R++  E  +  +S E
Sbjct: 1914 ADIAESQVNKLRVKSREVHTKVISEE 1939


>gi|28416946 myosin 18A isoform a [Homo sapiens]
          Length = 2054

 Score =  117 bits (293), Expect = 6e-26
 Identities = 156/737 (21%), Positives = 335/737 (45%), Gaps = 101/737 (13%)

Query: 137  EKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICLL 196
            EK M EL    +  K+    +  +++ A   R   I    ++     E+  K +  +  +
Sbjct: 1323 EKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAVREV 1382

Query: 197  EQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLT-- 254
            +   +RL++  + +++ +++ +++ E+R+  L+ +  + +     +  + QRLTA+L   
Sbjct: 1383 DFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDT 1442

Query: 255  ---LQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMA 311
               L+ Q+++      K+      L++A    EE +  +L++E      K  +++D ++A
Sbjct: 1443 KLHLEGQQVRNHELEKKQRRFDSELSQA---HEEAQREKLQRE------KLQREKDMLLA 1493

Query: 312  KLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAE 371
            +  +   Q  +    +A  ++++  L          E ELQDI  + SK E   A +  +
Sbjct: 1494 EAFSLKQQLEEKDMDIAGFTQKVVSL----------EAELQDISSQESKDEASLAKVKKQ 1543

Query: 372  VEELRKRVLDMEGKDEE---LIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALE 428
            + +L  +V D E + +E    I+M EQ + L   +E E ++    K E+E         E
Sbjct: 1544 LRDLEAKVKDQEEELDEQAGTIQMLEQAK-LRLEMEMERMRQTHSK-EMESRD------E 1595

Query: 429  KLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKEL-EAIESRLEKTEFTLK 487
            ++E+A    +++   ++  LE+E    +++ +E   L+ ++  L + +  R  ++E  L+
Sbjct: 1596 EVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLR 1655

Query: 488  EDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVT----------- 536
            +DL + K L     D +  +         K + A  + Q+E+++ T              
Sbjct: 1656 KDLKRTKAL---LADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVE 1712

Query: 537  -EKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDL-------------- 581
             E L  +     K+KT +EE++  + +E+++++N+L+ ++E  N+L              
Sbjct: 1713 IEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRD 1772

Query: 582  LSRVNMLKNRLQSLEAIEKDFLKNKLN---------QDSGKSTTALHQENNKIKELSQEV 632
            L+++N L+ +L+     EK  L+ KL          + S    + + ++  KI+EL   +
Sbjct: 1773 LAQINDLQAQLEEANK-EKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRL 1831

Query: 633  ERLKLKLKDMKAIEDDLMKTEDEY-ETLERRYA---NERDKAQFLSKELEHVKMELAKY- 687
            E  + ++K ++++   L +  ++  E  ++R A    E+++ + L ++L   K E+ +  
Sbjct: 1832 EFERTQVKRLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELA 1891

Query: 688  -KLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMA----------TEDLI 736
             K AE +   HE  L   L+  EA +  L  ++    ++I +  A           EDLI
Sbjct: 1892 RKEAEASRKKHE--LEMDLESLEAANQSLQADLKLAFKRIGDLQAAIEDEMESDENEDLI 1949

Query: 737  CHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPSL-----NGRRIS 791
              LQ   +  QK+ N+ E  + D+  E+E+    ++ +   SK+  PS         + S
Sbjct: 1950 NSLQDMVTKYQKRKNKLEG-DSDVDSELEDRVDGVKSW--LSKNKGPSKAASDDGSLKSS 2006

Query: 792  DPQVFSKEVQTEAVDNE 808
             P  + K +  +  D+E
Sbjct: 2007 SPTSYWKSLAPDRSDDE 2023



 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 119/647 (18%), Positives = 277/647 (42%), Gaps = 113/647 (17%)

Query: 210  EIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKE 269
            E++  EE+ + K++ +  L+ +L K +        E+  L         +I ELT+   +
Sbjct: 1248 EVQLSEEQIRNKDEEIQQLRSKLEKAEK-------ERNELRLNSDRLESRISELTSELTD 1300

Query: 270  THTKLALAEARVQEEEQKATRLEKELQTQTTKFH--------QDQDTIMAKLTNEDSQNR 321
                   A   +  E  +  R EKE++   T++          + + + A+L      N 
Sbjct: 1301 ERNTGESASQLLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEING 1360

Query: 322  QLQQKLAA------LSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEEL 375
            ++    A         R + E++ T + L++  E+  +++++  +             +L
Sbjct: 1361 EVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKR-------------QL 1407

Query: 376  RKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFN 435
             +R+ D++   EE    +   + L K+ +R T + +D KL +E    R   LEK +  F+
Sbjct: 1408 ERRLGDLQADSEE---SQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFD 1464

Query: 436  KSKQ-------------------------ECYSLKCNLEKERMTTKQLSQELESLKVRIK 470
                                         E +SLK  LE++ M     +Q++ SL+  ++
Sbjct: 1465 SELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQ 1524

Query: 471  ELEAIESRLEKTEFTLKEDLTKLKTL-------------TVMFVDE------------RK 505
            ++ + ES+ E +   +K+ L  L+               T+  +++            R+
Sbjct: 1525 DISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQ 1584

Query: 506  TMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKE-- 563
            T S++++  +++++ A    Q +  ++    E+  E+ ++ L+ K ++E K+ +++ +  
Sbjct: 1585 THSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVN 1644

Query: 564  -RD-DLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDF--LKNKLNQDSGKSTTALH 619
             RD + + +L+ + ++   LL+   ++ + L++    +++   LKN+L +       A+ 
Sbjct: 1645 RRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVK 1704

Query: 620  QENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEH 679
                  K +  E+E L L++       DD+ K +   E    R   E+++ Q   +E + 
Sbjct: 1705 AR----KAMEVEIEDLHLQI-------DDIAKAKTALEEQLSRLQREKNEIQNRLEEDQE 1753

Query: 680  VKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHL 739
               EL K   A   + S +     ++ + +A+    ++E   L+EK+    +  + +   
Sbjct: 1754 DMNELMKKHKAAVAQASRD---LAQINDLQAQLEEANKEKQELQEKLQALQSQVEFL--- 1807

Query: 740  QGDHSVLQKKL-NQQENRNRDLGREIENLTKELERYRHFSKSLRPSL 785
              + S++ K L ++QE + R+L   +E    +++R    +  L+ ++
Sbjct: 1808 --EQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLASRLKENM 1852



 Score = 91.3 bits (225), Expect = 5e-18
 Identities = 127/611 (20%), Positives = 256/611 (41%), Gaps = 103/611 (16%)

Query: 20   TKGHSFQGPKNMKHRQQDKDSPSESDVILPCPKAEKPHSGNGHQAEDLSRDDLLFLLSIL 79
            TK H  +G +   H  + K    +S++     +A++       Q E L R+  + L    
Sbjct: 1442 TKLH-LEGQQVRNHELEKKQRRFDSELSQAHEEAQREKL----QREKLQREKDMLLAEAF 1496

Query: 80   EGELQARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEA-LQRDAFQAKSTPWQEDIYEK 138
              + Q        L+ + MD+A      GF      LEA LQ  + Q           +K
Sbjct: 1497 SLKQQ--------LEEKDMDIA------GFTQKVVSLEAELQDISSQESKDEASLAKVKK 1542

Query: 139  PMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICLLEQ 198
             + +L+  V+  +E      G + + E+++ +  +E+E  ++ H + ME  DE +    Q
Sbjct: 1543 QLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQ 1602

Query: 199  ECERLKKLIDQEIKSQEEKE---------QEKEKRVTTLKEELTKLKSFALMVVDEQQRL 249
             C+  KKL   E++ +EE E         +E E ++ TL +++ +    +   + +  + 
Sbjct: 1603 SCQ--KKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKR 1660

Query: 250  TAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEE---------QKATRLEKE------ 294
            T  L    Q + +   N+  +  ++A  + +++E E         +KA  +E E      
Sbjct: 1661 TKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQI 1720

Query: 295  ---------LQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQK----LAALSRQIDELEETN 341
                     L+ Q ++  ++++ I  +L  +     +L +K    +A  SR + ++ +  
Sbjct: 1721 DDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQ 1780

Query: 342  RSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNK 401
              L +A +E Q+++EK+         + ++VE L + ++D       + + E + R+L  
Sbjct: 1781 AQLEEANKEKQELQEKLQ-------ALQSQVEFLEQSMVD----KSLVSRQEAKIRELET 1829

Query: 402  RLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQE 461
            RLE E  Q K     +E L+ R+   E +E    +  Q   +   N EKE+   K+L ++
Sbjct: 1830 RLEFERTQVK----RLESLASRLK--ENMEKLTEERDQRIAAE--NREKEQ--NKRLQRQ 1879

Query: 462  LESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAA 521
            L   K  + EL   E+   + +  L+ DL  L+        + K      K+  D   A 
Sbjct: 1880 LRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQADLKL---AFKRIGDLQAAI 1936

Query: 522  SSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDL 581
              +++ ++N+                    D+   +  +  +    KNKL+ + +  ++L
Sbjct: 1937 EDEMESDENE--------------------DLINSLQDMVTKYQKRKNKLEGDSDVDSEL 1976

Query: 582  LSRVNMLKNRL 592
              RV+ +K+ L
Sbjct: 1977 EDRVDGVKSWL 1987


>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
            sapiens]
          Length = 1938

 Score =  116 bits (290), Expect = 1e-25
 Identities = 138/665 (20%), Positives = 292/665 (43%), Gaps = 94/665 (14%)

Query: 188  KSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQ 247
            ++++ +  ++++ ER K    +E+   E + +E E+++ +L +E   L+   L V  E  
Sbjct: 848  EAEKEMATMKEDFERTK----EELARSEARRKELEEKMVSLLQEKNDLQ---LQVQSE-- 898

Query: 248  RLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRL---EKELQTQTTKFHQ 304
              T  L    ++ + L  +      K+     R++EEE+  + L   ++ L+ + +   +
Sbjct: 899  --TENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKR 956

Query: 305  DQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEK----ISK 360
            D D +   LT  + +    + K+  LS ++  LEE    L K ++ LQ+  ++    +  
Sbjct: 957  DIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQV 1016

Query: 361  GEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKL 420
             E    G++    +L ++  D+EG  E+  K+        ++LE +   S++  +++E  
Sbjct: 1017 EEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLEND 1076

Query: 421  SKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELE------- 473
             ++I      E+   K + E   L+  ++ E++ + Q  ++++ L+ RI+ELE       
Sbjct: 1077 KQQI------EEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEH 1130

Query: 474  AIESRLEKTEFTLKEDLTKL------------------KTLTVMFVDERKTMSE------ 509
             + +++EK    L  +L ++                  K     F   R+ + E      
Sbjct: 1131 TLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHE 1190

Query: 510  ---------------KLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVE 554
                           +L +  D LQ    +L+ E++++    + +    +   KSK+++E
Sbjct: 1191 ATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIE 1250

Query: 555  EKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSL--EAIEKDFLKNKLNQDSG 612
                +V    +D  +++KA++E+   L+  +NM K RLQ+   E   +   K  L     
Sbjct: 1251 RTCRTV----EDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLT 1306

Query: 613  KSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQF 672
            KS  AL Q+   ++EL +++E    + K   A+   L  +  + + L  +Y  E++    
Sbjct: 1307 KSKQALTQQ---LEELKRQMEE---ETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAE 1360

Query: 673  LSKELEHVKMELAKYKLAEKTET--------SHEQWLFKRLQEEEAKSGHLSREVDAL-K 723
            L + L     E+A+++   +T+           ++ L +RLQE E  +   + +  +L K
Sbjct: 1361 LQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEK 1420

Query: 724  EKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLG---REIENLTKELERYRHFSKS 780
             K       EDL+  L+  H+       +Q N ++ L    ++++    ELE  +  S+S
Sbjct: 1421 TKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRS 1480

Query: 781  LRPSL 785
            L   L
Sbjct: 1481 LSTEL 1485



 Score =  102 bits (255), Expect = 2e-21
 Identities = 136/668 (20%), Positives = 293/668 (43%), Gaps = 76/668 (11%)

Query: 31   MKHRQQDKDSPSESDVILPCPKAEKPHSGNGHQAEDLSRDDLLFLLSILEGELQARDEVI 90
            + HR ++K+S     +I    K+++  +    Q E+L R         +E E +A++ + 
Sbjct: 1291 LSHRVEEKES-----LISQLTKSKQALT---QQLEELKRQ--------MEEETKAKNAMA 1334

Query: 91   GILKAEKMDLALLEAQYGFVTPKKVLEALQRDAFQAKS------TPWQEDIY------EK 138
              L++ + D  LL  QY      K    LQR   +A S      T ++ D        E+
Sbjct: 1335 HALQSSRHDCDLLREQYEEEQEAKA--ELQRALSKANSEVAQWRTKYETDAIQRTEELEE 1392

Query: 139  PMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICLLEQ 198
               +L + +++ +E+      +    EK++++   E+E+  R     +E+S      L++
Sbjct: 1393 AKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRD----LERSHTACATLDK 1448

Query: 199  ECERLKKLIDQEIKSQEEKEQEKE---KRVTTLKEELTKLKSFALMVVDEQQRLTAQLTL 255
            +     K++ +  +  +E + E E   K   +L  EL K+++    VVD+ + L  +   
Sbjct: 1449 KQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKN 1508

Query: 256  QRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTN 315
             +++I +LT    ET   L  AE   +  EQ+ + L+  L           + +   L +
Sbjct: 1509 LQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVAL-----------EEVEGSLEH 1557

Query: 316  EDSQNRQLQQKLAALSRQID--------ELEETNRSLRKAEEELQDIKEKISKGEYGNAG 367
            E+S+  ++Q +L+ +  ++D        E+E+  R+ ++A E LQ + +   +       
Sbjct: 1558 EESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALR 1617

Query: 368  IMAEVE-ELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMA 426
            +  ++E +L +  + +   + ++ + ++  R +  +L+   L   D     E L +++  
Sbjct: 1618 LKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAI 1677

Query: 427  LEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTL 486
            +E+      +  +E   +K  LE+   T +   QEL     R++ L +  + L  T+  L
Sbjct: 1678 VERRNGLLLEELEE---MKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKL 1734

Query: 487  KEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTV--TEKLIEETK 544
            + D+ + +      + E +   EK KK        + +L+ EQ+    +   +K +E+T 
Sbjct: 1735 EADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTV 1794

Query: 545  RALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLK 604
            + L+ + D  E++             LK  +++   L +RV  L+N L   +    + LK
Sbjct: 1795 KDLQHRLDEAEQL------------ALKGGKKQIQKLENRVRELENELDVEQKRGAEALK 1842

Query: 605  --NKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERR 662
              +K  +   + T    +++  I  L   V++L+ K+K  K   ++  +  +   +  RR
Sbjct: 1843 GAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRR 1902

Query: 663  YANERDKA 670
              +E ++A
Sbjct: 1903 VQHELEEA 1910



 Score =  102 bits (254), Expect = 2e-21
 Identities = 162/772 (20%), Positives = 346/772 (44%), Gaps = 100/772 (12%)

Query: 70   DDLLFLLSILEGELQARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQRDAFQAKST 129
            DDL   L+ +E E  A +  +  L  E   +  LE     +T +K  ++LQ +A Q    
Sbjct: 959  DDLELTLTKVEKEKHATENKVKNLSEE---MTALEENISKLTKEK--KSLQ-EAHQQTLD 1012

Query: 130  PWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKS 189
              Q  + E  +N L K+  K ++    + G L   +K R     +LE  KRK +  ++ S
Sbjct: 1013 DLQ--VEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRA----DLERAKRKLEGDLKMS 1066

Query: 190  DEFICLLEQECERL-KKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQR 248
             E I  LE + +++ +KL  +E +  + + +  +++V +L+ +  K+K     + + ++ 
Sbjct: 1067 QESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQ-KKIKELQARIEELEEE 1125

Query: 249  LTAQLTLQRQKIQELTTNAKETHTKLA--LAEARVQEEEQKATRLEKELQTQTTKFHQDQ 306
            + A+ TL R KI++  ++      +++  L EA      Q     ++E + Q  +   ++
Sbjct: 1126 IEAEHTL-RAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEE 1184

Query: 307  DTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQ----DIKEKISKGE 362
             T+  + T    + +Q    +A L  QID L+   + L K + EL+    D+   I    
Sbjct: 1185 ATLQHEATAATLRKKQ-ADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALS 1243

Query: 363  YGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSK 422
               + I      +  +  +++ KDE+  ++     DLN +  R   Q+ +    VE+   
Sbjct: 1244 KSKSNIERTCRTVEDQFSEIKAKDEQQTQL---IHDLNMQKARLQTQNGELSHRVEEKES 1300

Query: 423  RIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELES-------LKVRIKELEAI 475
             I  L K + A  +  +E   LK  +E+E      ++  L+S       L+ + +E +  
Sbjct: 1301 LISQLTKSKQALTQQLEE---LKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEA 1357

Query: 476  ESRLE----KTEFTLKEDLTKLKTLTVMFVDE----RKTMSEKLKKTEDKLQAASSQ--- 524
            ++ L+    K    + +  TK +T  +   +E    +K ++++L++ E+  + A+S+   
Sbjct: 1358 KAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCAS 1417

Query: 525  LQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTK-------ERDDLKNKLKAEEEK 577
            L+  + ++    E L+ + +R+  +   +++K  +  K       + D+ + +L+A +++
Sbjct: 1418 LEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKE 1477

Query: 578  GNDLLSRVNMLKN-------RLQSLEAIEKDFLK------------NKLNQDSGKSTTAL 618
               L + +  ++N       +L++L    K+  +             K  Q++ K+   +
Sbjct: 1478 SRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLV 1537

Query: 619  HQENNKIKELSQEVE-----------RLKLKLKDMKA-IEDDLMKTEDEYETLERRYANE 666
             QE + ++   +EVE           R++L+L  +K+ ++  +++ ++E E L+R   N 
Sbjct: 1538 EQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKR---NS 1594

Query: 667  RDKAQFLSKELE-HVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEK 725
            +  A+ L   L+  ++      +L +K E          L E E + GH +R++   ++ 
Sbjct: 1595 QRAAEALQSVLDAEIRSRNDALRLKKKMEGD--------LNEMEIQLGHSNRQMAETQKH 1646

Query: 726  IHEYMA-TEDLICHLQG---DHSVLQKKLNQQENRNRDLGREIENLTKELER 773
            +       +D   HL      +  L+++L   E RN  L  E+E +   LE+
Sbjct: 1647 LRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQ 1698



 Score = 99.8 bits (247), Expect = 1e-20
 Identities = 106/543 (19%), Positives = 253/543 (46%), Gaps = 65/543 (11%)

Query: 287  KATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRK 346
            K+   EKE+ T    F + ++    +L   +++ ++L++K+ +L ++ ++L+     ++ 
Sbjct: 845  KSAEAEKEMATMKEDFERTKE----ELARSEARRKELEEKMVSLLQEKNDLQ---LQVQS 897

Query: 347  AEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELI----KMEEQCRDLNKR 402
              E L D +E+          + A+V+EL +R+ + E  + EL+     +E++C  L + 
Sbjct: 898  ETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRD 957

Query: 403  LERETLQSKDFKLE-------VEKLSKRIMALEKLEDAFNKSK---QECYSLKCN---LE 449
            ++   L     + E       V+ LS+ + ALE+      K K   QE +    +   +E
Sbjct: 958  IDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVE 1017

Query: 450  KERMT-----TKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDER 504
            ++++        +L Q+ + L+  +++ + + + LE+ +  L+ DL   +   +   +++
Sbjct: 1018 EDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDK 1077

Query: 505  KTMSEKLKKTE----------DKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVE 554
            + + EKLKK E          D  Q  S Q Q +  ++    E+L EE +     +  +E
Sbjct: 1078 QQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIE 1137

Query: 555  EKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKS 614
            ++   + +E +++  +L   EE      +++ M K R    + + +D  +  L  ++  +
Sbjct: 1138 KQRSDLARELEEISERL---EEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAA 1194

Query: 615  TTALHQENN------------KIKE-LSQEVERLKLKLKDMKAIEDDLMKTEDEYE---- 657
            T    Q ++            ++K+ L +E   LK+++ DM +  + L K++   E    
Sbjct: 1195 TLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCR 1254

Query: 658  TLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGH-LS 716
            T+E +++  + K +  ++ +  + M+ A+ +  +  E SH     + L  +  KS   L+
Sbjct: 1255 TVEDQFSEIKAKDEQQTQLIHDLNMQKARLQ-TQNGELSHRVEEKESLISQLTKSKQALT 1313

Query: 717  REVDALKEKIHEYMATEDLICHL----QGDHSVLQKKLNQQENRNRDLGREIENLTKELE 772
            ++++ LK ++ E    ++ + H     + D  +L+++  +++    +L R +     E+ 
Sbjct: 1314 QQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVA 1373

Query: 773  RYR 775
            ++R
Sbjct: 1374 QWR 1376



 Score = 78.6 bits (192), Expect = 3e-14
 Identities = 103/474 (21%), Positives = 206/474 (43%), Gaps = 76/474 (16%)

Query: 335  DELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIK--- 391
            ++ E T   L ++E   ++++EK+         +  +V+   + ++D E + E LIK   
Sbjct: 858  EDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSKI 917

Query: 392  -MEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEK-LEDAFNKSKQECYSLKCNLE 449
             +E + ++L +RLE E           E+++  ++A ++ LED       +C SLK +++
Sbjct: 918  LLEAKVKELTERLEEE-----------EEMNSELVAKKRNLED-------KCSSLKRDID 959

Query: 450  KERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSE 509
               +T  ++ +E  + + ++K L    + LE       E+++KL         E+K++ E
Sbjct: 960  DLELTLTKVEKEKHATENKVKNLSEEMTALE-------ENISKL-------TKEKKSLQE 1005

Query: 510  KLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKN 569
              ++T D        LQVE++KV      LI+   +  +   D+E  +    K R DL+ 
Sbjct: 1006 AHQQTLD-------DLQVEEDKVNG----LIKINAKLEQQTDDLEGSLEQEKKLRADLER 1054

Query: 570  -KLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKEL 628
             K K E +           LK   +S+  +E D  K ++ +   K    L Q   KI + 
Sbjct: 1055 AKRKLEGD-----------LKMSQESIMDLEND--KQQIEEKLKKKEFELSQLQAKIDDE 1101

Query: 629  SQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMEL---- 684
                 + + K+K+++A  ++L +  +   TL  +   +R     L++ELE +   L    
Sbjct: 1102 QVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSD---LARELEEISERLEEAS 1158

Query: 685  ----AKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQ 740
                A+ ++ +K E   ++    R   EEA   H +      K++        + I +LQ
Sbjct: 1159 GATSAQIEMNKKREAEFQKM---RRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQ 1215

Query: 741  GDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPSLNGRRISDPQ 794
                 L+K+ ++ +    D+   IE L+K         +++    +  +  D Q
Sbjct: 1216 RVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQ 1269



 Score = 68.9 bits (167), Expect = 3e-11
 Identities = 81/350 (23%), Positives = 155/350 (44%), Gaps = 68/350 (19%)

Query: 522  SSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGND- 580
            S++ + E   +    E+  EE  R+   + ++EEKM S+ +E++DL+ ++++E E   D 
Sbjct: 846  SAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDA 905

Query: 581  -------------LLSRVNMLKNRLQSLEAIEKDFLKNKLNQDS---------------- 611
                         L ++V  L  RL+  E +  + +  K N +                 
Sbjct: 906  EERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTL 965

Query: 612  GKSTTALHQENNKIKELSQEV----ERLKLKLKDMKAIE-------DDLMKTEDEYETLE 660
             K     H   NK+K LS+E+    E +    K+ K+++       DDL   ED+   L 
Sbjct: 966  TKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLI 1025

Query: 661  RRYANERDKAQFLSKELEHVK-----MELAKYKLAEKTETSHE---------QWLFKRLQ 706
            +  A    +   L   LE  K     +E AK KL    + S E         Q + ++L+
Sbjct: 1026 KINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLK 1085

Query: 707  EEEAKSGHLSREVD-------ALKEKIHEYMA-TEDLICHLQGDHSVLQKKLNQQENRNR 758
            ++E +   L  ++D         ++KI E  A  E+L   ++ +H+ L+ K+ +Q +   
Sbjct: 1086 KKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHT-LRAKIEKQRS--- 1141

Query: 759  DLGREIENLTKELERYRHFSKSLRPSLNGRRISDPQVFSKEVQTEAVDNE 808
            DL RE+E +++ LE     + S +  +N +R ++ Q   ++++   + +E
Sbjct: 1142 DLARELEEISERLEE-ASGATSAQIEMNKKREAEFQKMRRDLEEATLQHE 1190


>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
            sapiens]
          Length = 1937

 Score =  116 bits (290), Expect = 1e-25
 Identities = 139/652 (21%), Positives = 275/652 (42%), Gaps = 91/652 (13%)

Query: 201  ERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKI 260
            E  +K  D+  KS+ ++++ +EK VT LKE+        L V  E   L        ++ 
Sbjct: 857  EEFQKTKDELAKSEAKRKELEEKMVTLLKEK----NDLQLQVQSEADSLADA----EERC 908

Query: 261  QELTTNAKETHTKLALAEARVQEEEQ---KATRLEKELQTQTTKFHQDQDTIMAKLTNED 317
            ++L  N  +   K+     R +EEE+   + T  +++L+ + ++  +D D +   L   +
Sbjct: 909  EQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVE 968

Query: 318  SQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKI---SKGEYGNAGIMAEVE- 373
             +    + K+  L+ ++  L+ET   L K ++ LQ+  ++     + E     I+ + + 
Sbjct: 969  KEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKT 1028

Query: 374  ELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDA 433
            +L ++V D+EG  E+  K+        ++LE       D KL  E         ++L++ 
Sbjct: 1029 KLEQQVDDLEGSLEQEKKLRMDLERAKRKLE------GDLKLAQESTMDMENDKQQLDEK 1082

Query: 434  FNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRI------------------------ 469
              K + E  +L   +E E+    QL ++++ L+ RI                        
Sbjct: 1083 LEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDL 1142

Query: 470  -KELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSE------------------- 509
             +ELE I  RLE+        +   K     F   R+ + E                   
Sbjct: 1143 SRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADS 1202

Query: 510  --KLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDL 567
              +L +  D LQ    +L+ E++++   T+ L    +   K+K ++E+   S+  +  +L
Sbjct: 1203 MAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSEL 1262

Query: 568  KNKLKAEEEKGNDLLSRVNMLKNRL--QSLEAIEKDFLKNKLNQDSGKSTTALHQENNKI 625
            K K + ++   NDL ++   L+      S +  EKD L ++L++    ST        +I
Sbjct: 1263 KTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQAST-------QQI 1315

Query: 626  KELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELA 685
            +EL  ++E    + K   A+   L  +  + + L  +Y  E++    L + L     E+A
Sbjct: 1316 EELKHQLEE---ETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVA 1372

Query: 686  KYKLAEKTET--------SHEQWLFKRLQEEEAKSGHLSREVDAL-KEKIHEYMATEDLI 736
            +++   +T+           ++ L +RLQE E     ++ +  +L K K       EDL+
Sbjct: 1373 QWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLM 1432

Query: 737  CHLQGDHSVLQKKLNQQENRNRDLG---REIENLTKELERYRHFSKSLRPSL 785
              ++  ++       +Q N ++ L    ++ E    ELE  +  S+SL   L
Sbjct: 1433 LDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTEL 1484



 Score =  110 bits (274), Expect = 1e-23
 Identities = 178/772 (23%), Positives = 329/772 (42%), Gaps = 111/772 (14%)

Query: 82   ELQARDEVIGI-LKAEKMDLALLEAQYGFVTPKKVLEALQRDAFQAKSTPWQEDIYEKPM 140
            ELQAR E +G  ++AE+   A  E Q   ++ +++ E  +R      +T  Q ++ +K  
Sbjct: 1113 ELQARIEELGEEIEAERASRAKAEKQRSDLS-RELEEISERLEEAGGATSAQVELNKKRE 1171

Query: 141  NELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICLLEQEC 200
             E  K+    +E+  +    +    K    ++ EL E+    +   +K       LE+E 
Sbjct: 1172 AEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQK-------LEKEK 1224

Query: 201  ERLKKLIDQEIKSQEEKEQEK---EKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQR 257
              LK   D    + E   + K   EK   +L++++++LK+      +EQQRL   LT QR
Sbjct: 1225 SELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKE----EEQQRLINDLTAQR 1280

Query: 258  QKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNED 317
             ++Q   T A E   +L        E++   ++L +  Q  T    Q  + +  +L  E 
Sbjct: 1281 ARLQ---TEAGEYSRQL-------DEKDALVSQLSRSKQAST----QQIEELKHQLEEET 1326

Query: 318  SQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKIS------KGEYGNAGIMA- 370
                 L   L +     D L E     ++ + ELQ    K +      + +Y    I   
Sbjct: 1327 KAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRT 1386

Query: 371  -EVEELRKRVLD-MEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALE 428
             E+EE +K++   ++  +E +  +  +C  L K  +R   + +D  L+VE+ +    AL+
Sbjct: 1387 EELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALD 1446

Query: 429  KLEDAFNKS----KQECYSLKCNLEKERMTTKQLSQELESLK-VRIKELEAIESRLEKTE 483
            K +  F+K     KQ+    +  LE  +  ++ LS EL  +K V  + L+ +E+ L +  
Sbjct: 1447 KKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLET-LRREN 1505

Query: 484  FTLKEDLTKLKTLTVMFVDERKTMSE--KLKKTEDK--------LQAASSQLQVEQNKVT 533
              L+++++ L   T    +  K + E  K+KK  ++        L+ A + L+ E+ K+ 
Sbjct: 1506 KNLQQEISDL---TEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKIL 1562

Query: 534  TVTEKLIE---ETKRALKSKTD-VEEKMYSVTKERDDLKNKLKAEEEKGNDLL------- 582
             +  +L +   E  R +  K + +++   + T+  + +++ L AE    ND L       
Sbjct: 1563 RIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKME 1622

Query: 583  SRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQEN-----NKIKE---------- 627
              +N ++ +L     +  + L+N  N       T LH ++       +KE          
Sbjct: 1623 GDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRAN 1682

Query: 628  -LSQEVERLKLKL----KDMKAIEDDLMKTEDEYETLERRYAN--------ERDKAQFLS 674
             L  E+E L   L    +  K  E +L+   +  + L  +  +        E D +Q L 
Sbjct: 1683 LLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQ-LQ 1741

Query: 675  KELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKI----HEYM 730
             E+E V  E    +   K   +    + + L++E+  S HL R    L++ +    H   
Sbjct: 1742 SEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLD 1801

Query: 731  ATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLR 782
              E L   L+G     +K++ + E R R+L  E+EN   E +R     K LR
Sbjct: 1802 EAEQLA--LKGG----KKQIQKLEARVRELEGEVEN---EQKRNAEAVKGLR 1844



 Score =  109 bits (272), Expect = 2e-23
 Identities = 105/545 (19%), Positives = 255/545 (46%), Gaps = 69/545 (12%)

Query: 287  KATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRK 346
            K+   EKE+ T   +F + +D    +L   +++ ++L++K+  L ++ ++L+     ++ 
Sbjct: 844  KSAETEKEMATMKEEFQKTKD----ELAKSEAKRKELEEKMVTLLKEKNDLQ---LQVQS 896

Query: 347  AEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELI----KMEEQCRDLNK- 401
              + L D +E+  +       + A+++E+ +R  + E  + EL     K+E++C +L K 
Sbjct: 897  EADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKD 956

Query: 402  ---------RLERETLQS----KDFKLEVEKLSKRIMALEKLEDAFNKSKQECYS-LKCN 447
                     ++E+E   +    K+   E+  L + I  L K + A  ++ Q+    L+  
Sbjct: 957  IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAE 1016

Query: 448  LEKERMTTK---QLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDER 504
             +K  + TK   +L Q+++ L+  +++ + +   LE+ +  L+ DL   +  T+   +++
Sbjct: 1017 EDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDK 1076

Query: 505  KTMSEKLKKTEDKL----------QAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVE 554
            + + EKL+K E ++          QA   QLQ +  ++    E+L EE +    S+   E
Sbjct: 1077 QQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAE 1136

Query: 555  EKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDS--- 611
            ++   +++E +++  +L   EE G    ++V + K R    + + +D  +  L  ++   
Sbjct: 1137 KQRSDLSRELEEISERL---EEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVA 1193

Query: 612  ------GKSTTALHQENNKIKELSQEVER----LKLKLKDMKAIEDDLMKTEDEYETLER 661
                    S   L ++ + ++ + Q++E+    LK++  D+ +  + + K +   E + R
Sbjct: 1194 ALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCR 1253

Query: 662  RYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSR---- 717
               ++  + +   +E + +  +L   +   +TE        ++L E++A    LSR    
Sbjct: 1254 SLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYS---RQLDEKDALVSQLSRSKQA 1310

Query: 718  ---EVDALKEKIHEYMATEDLICHL----QGDHSVLQKKLNQQENRNRDLGREIENLTKE 770
               +++ LK ++ E    ++ + H     + D  +L+++  +++    +L R +     E
Sbjct: 1311 STQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSE 1370

Query: 771  LERYR 775
            + ++R
Sbjct: 1371 VAQWR 1375



 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 127/624 (20%), Positives = 271/624 (43%), Gaps = 66/624 (10%)

Query: 79   LEGELQARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQRDAFQAKS------TPWQ 132
            LE E +A++ +   L++ + D  LL  QY      K    LQR   +A S      T ++
Sbjct: 1322 LEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKA--ELQRALSKANSEVAQWRTKYE 1379

Query: 133  EDIY------EKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYM 186
             D        E+   +L + +++ +E    +  +    EK++++   E+E+        +
Sbjct: 1380 TDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLD----V 1435

Query: 187  EKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKE---KRVTTLKEELTKLKSFALMVV 243
            E+S+     L+++     K++ +  +  EE + E E   K   +L  EL K+K+     +
Sbjct: 1436 ERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESL 1495

Query: 244  DEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFH 303
            D+ + L  +    +Q+I +LT    E   ++   E   ++ EQ+   ++  L+       
Sbjct: 1496 DQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLE 1555

Query: 304  QDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEY 363
             ++  I+      +    ++ +K+A    +ID+L+  +  + +  +   D          
Sbjct: 1556 HEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLD---------- 1605

Query: 364  GNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQS--------KDFKL 415
              A I +  + LR +   MEG   +L +ME Q    N RL  E+L++        K+ +L
Sbjct: 1606 --AEIRSRNDALRVK-KKMEG---DLNEMEIQLNHAN-RLAAESLRNYRNTQGILKETQL 1658

Query: 416  EVEKLSKRIMALEK----LEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKE 471
             ++   +    L++    +E   N  + E   L   LE+   + K   QEL     R++ 
Sbjct: 1659 HLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQL 1718

Query: 472  LEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNK 531
            L    + L  T+  L+ D+++L++     + E +   EK KK        + +L+ EQ+ 
Sbjct: 1719 LHTQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDT 1778

Query: 532  VTTV--TEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLK 589
               +   +K +E+T + L+ + D  E++             LK  +++   L +RV  L+
Sbjct: 1779 SAHLERMKKNLEQTVKDLQHRLDEAEQL------------ALKGGKKQIQKLEARVRELE 1826

Query: 590  NRLQSLEAIEKDFLKN-KLNQDSGKSTTALHQENNK-IKELSQEVERLKLKLKDMKAIED 647
              +++ +    + +K  + ++   K  T   +E+ K +  L   V++L+ K+K  K   +
Sbjct: 1827 GEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAE 1886

Query: 648  DLMKTEDEYETLERRYANERDKAQ 671
            +  +  +   +  R+  +E ++A+
Sbjct: 1887 EAEEQSNANLSKFRKLQHELEEAE 1910



 Score = 80.9 bits (198), Expect = 6e-15
 Identities = 108/507 (21%), Positives = 215/507 (42%), Gaps = 82/507 (16%)

Query: 137  EKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSD------ 190
            +K     DKV+ + K+ Y     +L  ++K  R    EL + K  ++E +++ +      
Sbjct: 1446 DKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRREN 1505

Query: 191  -----EFICLLEQ---------ECERLKKLIDQE-------IKSQEEKEQEKEKRVTTLK 229
                 E   L EQ         E E++KK ++QE       ++  E   + +E ++  ++
Sbjct: 1506 KNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQ 1565

Query: 230  EELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEE-EQKA 288
             EL ++KS     + E+     QL     ++ E   +  +   +      RV+++ E   
Sbjct: 1566 LELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDL 1625

Query: 289  TRLEKELQ------TQTTKFHQDQDTIM--AKLTNEDSQNRQ--LQQKLAALSR------ 332
              +E +L        ++ + +++   I+   +L  +D+   Q  L+++LA + R      
Sbjct: 1626 NEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQ 1685

Query: 333  -QIDEL----EETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDE 387
             +I+EL    E+T RS + AE+EL D  E++      N  ++   ++L   V  ++ + E
Sbjct: 1686 AEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVE 1745

Query: 388  ELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCN 447
            E+I+      +  K+         D  +  E+L K       LE      +Q    L+  
Sbjct: 1746 EVIQESRNAEEKAKKA------ITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHR 1799

Query: 448  L-EKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTK----LKTLTVMFVD 502
            L E E++  K   ++++ L+ R++ELE      +K      + L K    +K LT    +
Sbjct: 1800 LDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTEE 1859

Query: 503  ERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTK 562
            +RK +  +L+   DKLQA                     + K   +   + EE+  +   
Sbjct: 1860 DRKNVL-RLQDLVDKLQA---------------------KVKSYKRQAEEAEEQSNANLS 1897

Query: 563  ERDDLKNKLKAEEEKGNDLLSRVNMLK 589
            +   L+++L+  EE+ +   S+VN L+
Sbjct: 1898 KFRKLQHELEEAEERADIAESQVNKLR 1924


>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
          Length = 1417

 Score =  116 bits (290), Expect = 1e-25
 Identities = 164/756 (21%), Positives = 308/756 (40%), Gaps = 130/756 (17%)

Query: 132  QEDIYEKPMN----------ELDKVVEKHKESYRRILGQLLVAEKSRR--QTILELEEEK 179
            QE++ EK  N          +  +++   K+   +I+    +A K+    Q ++E  E+ 
Sbjct: 675  QEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKI 734

Query: 180  RKHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEK-EQEKEKRVTTLKEELTKLKSF 238
            R  +  +    E ICL  ++ +++     +E++ Q E+ E + EK+    KE+   +   
Sbjct: 735  RSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSML 794

Query: 239  ALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLE------ 292
               ++ +Q  L +   L  +   E+     +    L   + +V EE  K  +L+      
Sbjct: 795  QQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEIC 854

Query: 293  -KELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEEL 351
             +EL     +   +++    +L  +  +   LQ++L   +  + E  E N  L+   ++ 
Sbjct: 855  KEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQ 914

Query: 352  QDI--KEKISKGEYGNAGIMAEVE------ELRKRVLDMEGKDEELIKMEEQCR------ 397
            Q +  +E I  GE  +     E +      EL+K+    E   E+L KMEE+C       
Sbjct: 915  QQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQ---RESSAEKLRKMEEKCESAAHEA 971

Query: 398  --------DLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLE 449
                    +L     +  ++   +K E+ K+ K IM L++  D  NK+         +L 
Sbjct: 972  DLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKR--DGENKAM--------HLS 1021

Query: 450  KERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVD---ERKT 506
            +  M   Q   ELE     +KELE ++     TE  L E L K + L     +   E K+
Sbjct: 1022 QLDMILDQTKTELEKKTNAVKELEKLQ---HSTETELTEALQKREVLETELQNAHGELKS 1078

Query: 507  MSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEK------MYSV 560
               +L++  D LQ A   L+ +   +  +T +L E        K ++E+K      M   
Sbjct: 1079 TLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRE-------CKMEIEDKKQELLEMDQA 1131

Query: 561  TKERD-DLKNK--------LKAEEEKGNDLLSRVNMLKNRLQSLEAIEK----------D 601
             KER+ +LK +        +   E +G ++  ++  L+  L+  E   K          D
Sbjct: 1132 LKERNWELKQRAAQVTHLDMTIREHRG-EMEQKIIKLEGTLEKSELELKECNKQIESLND 1190

Query: 602  FLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAI---------------- 645
             L+N   Q   K    L Q   +I +L +E+ER + ++K+M+++                
Sbjct: 1191 KLQNAKEQLREKEFIML-QNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAI 1249

Query: 646  --EDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFK 703
                +L  T ++ +      A  R +     +E+E +  EL   K   K + +H   L +
Sbjct: 1250 DLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAE 1309

Query: 704  RLQEEEAKSGH-----------LSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQ 752
             L   + +  H           LS EV++LKE  H      ++I H Q +H+  +   + 
Sbjct: 1310 ELGASKVREAHLEARMQAEIKKLSAEVESLKEAYH-----MEMISH-QENHAKWKISADS 1363

Query: 753  QENRNRDLGREIENLTKELERYRHFSKSLRPSLNGR 788
            Q++  + L  ++E    ELE  +    +L   +  R
Sbjct: 1364 QKSSVQQLNEQLEKAKLELEEAQDTVSNLHQQVQDR 1399



 Score = 97.1 bits (240), Expect = 9e-20
 Identities = 155/721 (21%), Positives = 306/721 (42%), Gaps = 101/721 (14%)

Query: 190 DEFICLLEQECERLKKLIDQEIKSQEEKEQ---EKEKRVTTLKEELTKLKSFALMVVDEQ 246
           +E I  LE E     K++ +     E+ ++   EKE+ +   KEE  KLK      VD  
Sbjct: 290 EEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLK------VDLL 343

Query: 247 QRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQ 306
           ++       +RQ+  E   NA+E      L++A  Q +++ A +LEK           ++
Sbjct: 344 EQTKQGKRAERQR-NEALYNAEE------LSKAFQQYKKKVAEKLEK--------VQAEE 388

Query: 307 DTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNA 366
           + +   LTN + +N++LQ++      +++ L+E    LR+ +EE  + KEK+      N+
Sbjct: 389 EILERNLTNCEKENKRLQERCGLYKSELEILKE---KLRQLKEENNNGKEKLRIMAVKNS 445

Query: 367 GIMAEVEELRKRVL----DMEGKDEEL---IKMEEQCRDLNKRLERETLQSKDFKLEVEK 419
            +MA++ E R+ +L    ++E KDE L     +  + R+L  R+  +  +    + E+E 
Sbjct: 446 EVMAQLTESRQSILKLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIES 505

Query: 420 LSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQE-----LESLKVRIKELE- 473
               + +LEK+       K+E +  K  L K +M++    ++      E+ K+ I EL  
Sbjct: 506 SRVELRSLEKIISQL-PLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRI 564

Query: 474 --AI-ESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQN 530
             AI E+ ++K    L  +      +T     E   +S  L+    KL        V+  
Sbjct: 565 KLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLS-SLETEPVKLGGHQVAESVKDQ 623

Query: 531 KVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLK--------------NKLKAEEE 576
              T+ ++  +E +R +    ++  K+  +  E  DLK               +L  +  
Sbjct: 624 NQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKAS 683

Query: 577 KGNDLLSRVNMLKNRLQSLE--AIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEV-- 632
             + L S +    ++L +LE    EK    + +   + +    L ++N KI+ L   +  
Sbjct: 684 NSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINT 743

Query: 633 ----------ERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKE------ 676
                     +  K+ L+  K +E  + + E + E  ++++  +      L ++      
Sbjct: 744 EHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQH 803

Query: 677 -LEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDL 735
            LE +   L + K   K E   +    K LQ + ++     R++D+  E     +  E+L
Sbjct: 804 HLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALE-----ICKEEL 858

Query: 736 ICH---LQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPSLNGRRISD 792
           + H   L+G+    +K+L ++      L +E++     L+     +  L+ +L       
Sbjct: 859 VLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTL------- 911

Query: 793 PQVFSKEVQTEAVDN-EPPDYKSLIPLERAVINGQLYEESENQDEDPNDEGSVLSFKCSQ 851
            Q   + +Q E + N E  D ++   LE+ V   +L +E + Q E   ++   +  KC  
Sbjct: 912 -QQQQQMLQQETIRNGELEDTQT--KLEKQV--SKLEQELQKQRESSAEKLRKMEEKCES 966

Query: 852 S 852
           +
Sbjct: 967 A 967



 Score = 77.4 bits (189), Expect = 7e-14
 Identities = 153/708 (21%), Positives = 292/708 (41%), Gaps = 141/708 (19%)

Query: 162 LVAEKSRRQTILELEEEKRKHKEYME-KSDEFICLLEQECERLKKLIDQEIKSQEEKEQE 220
           L AE S +  +L   E K +  + M  + ++ +   ++EC +LK  + ++ K  +  E++
Sbjct: 296 LEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAERQ 355

Query: 221 KEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEAR 280
           + + +    EEL+K                     Q+ K        K+   KL   +A 
Sbjct: 356 RNEALYN-AEELSK-------------------AFQQYK--------KKVAEKLEKVQAE 387

Query: 281 VQEEEQKATRLEKE---LQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAAL----SRQ 333
            +  E+  T  EKE   LQ +   +  + + +  KL     +N   ++KL  +    S  
Sbjct: 388 EEILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEV 447

Query: 334 IDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGK----DEEL 389
           + +L E+ +S+ K E EL++ K++I + ++    +M E  EL+ RV     +     +E+
Sbjct: 448 MAQLTESRQSILKLESELEN-KDEILRDKF---SLMNENRELKVRVAAQNERLDLCQQEI 503

Query: 390 IKMEEQCRDLNK-----RLERETLQSKDF--KLEVEKLSKR-----------IMALEKLE 431
                + R L K      L+RE    K +  K ++   S +            + + +L 
Sbjct: 504 ESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELR 563

Query: 432 DAFNKSKQECYSLKCNLEKERMTTKQLSQEL-------ESLKVRIKELEAIESRLEKTEF 484
                 + E   L  NL     T  QLSQ L       ES K+   E E ++    +   
Sbjct: 564 IKLAIKEAEIQKLHANL-----TANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAE 618

Query: 485 TLKEDLTKLKTLTVMFVDERK---TMSEKLKKTEDKLQAASSQLQVEQNKVTT----VTE 537
           ++K+      T+   +  ER+   T  E+L+    +++A +S L+V     T+    + E
Sbjct: 619 SVKDQ--NQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQE 676

Query: 538 KLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEE---KGNDLLSRVNMLKNRLQS 594
           +L+E+   + K ++++ +K   +      L+ K+ A      K  +L   +     +++S
Sbjct: 677 ELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRS 736

Query: 595 LEA-IEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKL-----------KDM 642
           LE  I  +  K  L  +  K    +H E +  KE+ +++ERL+ +L           K M
Sbjct: 737 LETNINTEHEKICLAFEKAKK---IHLEQH--KEMEKQIERLEAQLEKKDQQFKEQEKTM 791

Query: 643 KAIEDDL-------------------------MKTEDEYETLERRYANERDKAQFLSKEL 677
             ++ D+                         MK ++  + L+ + + E  K + L   L
Sbjct: 792 SMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSAL 851

Query: 678 EHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLIC 737
           E  K EL  +    + E + E++  K+L+++  +   L +E   LK K H    T +   
Sbjct: 852 EICKEELVLH--LNQLEGNKEKF-EKQLKKKSEEVYCLQKE---LKIKNHSLQETSEQNV 905

Query: 738 HLQGDHSVLQKKLNQQENRNRD-------LGREIENLTKELERYRHFS 778
            LQ      Q+ L Q+  RN +       L +++  L +EL++ R  S
Sbjct: 906 ILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESS 953



 Score = 53.9 bits (128), Expect = 8e-07
 Identities = 84/441 (19%), Positives = 198/441 (44%), Gaps = 67/441 (15%)

Query: 29   KNMKHRQQDKDSP----SESDVILPCPKAEKPHSGNG-------HQAEDLSRDDLLFLLS 77
            K + H ++D ++     S+ D+IL   K E     N          + +    + L    
Sbjct: 1004 KEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKRE 1063

Query: 78   ILEGELQ-ARDEVIGILKA-EKMDLALLEAQYGFVTPKKVLEALQRDAFQAKSTPWQEDI 135
            +LE ELQ A  E+   L+  +++   L +AQ         ++ L  +  + K    + + 
Sbjct: 1064 VLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKM---EIED 1120

Query: 136  YEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICL 195
             ++ + E+D+ +++     ++   Q+   + + R+   E+E++  K +  +EKS+    L
Sbjct: 1121 KKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSE----L 1176

Query: 196  LEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTL 255
              +EC +  + ++ ++++ +E+ +EKE  +   ++E+++LK     +   QQR+    ++
Sbjct: 1177 ELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKK---EIERTQQRMKEMESV 1233

Query: 256  QRQKIQELTTNAKE-----------------THTKLALAEARVQEEEQKATRLEKELQTQ 298
             +++ Q + T  KE                 +HT+LA A  +  + +++  RL  EL+  
Sbjct: 1234 MKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELED- 1292

Query: 299  TTKFHQDQDTIMAKLTNE-DSQNRQLQQKLAALSRQIDELEETNRS-LRKAEEELQDIKE 356
                       M +L+ E D+    L ++L A   +   LE   ++ ++K   E++ +KE
Sbjct: 1293 -----------MKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKE 1341

Query: 357  KISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLE 416
                    +  +++  E   K  +  + +   +       + LN++LE+  L+ ++ +  
Sbjct: 1342 AY------HMEMISHQENHAKWKISADSQKSSV-------QQLNEQLEKAKLELEEAQDT 1388

Query: 417  VEKLSKRIMALEKLEDAFNKS 437
            V  L +++    ++ +A N++
Sbjct: 1389 VSNLHQQVQDRNEVIEAANEA 1409



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 66/301 (21%), Positives = 125/301 (41%), Gaps = 43/301 (14%)

Query: 114  KVLEALQRDAFQAKSTPWQEDIYEKPMNELDKVVEKHK-ESYRRILGQLLVAEKSR---- 168
            K  E L+ D    K   W+       +  LD  + +H+ E  ++I+      EKS     
Sbjct: 1121 KKQELLEMDQ-ALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELK 1179

Query: 169  --RQTILELEEEKRKHKEYMEKSDEFICLLEQECERLKKLID---QEIKSQEEKEQEKEK 223
               + I  L ++ +  KE + + +  +   EQE  +LKK I+   Q +K  E   +E+E+
Sbjct: 1180 ECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQ 1239

Query: 224  RVTTLKEELTKL------------KSFALMVVDEQQRLTAQLTLQR--QKIQELTTNAKE 269
             + T  +E   L             S   +     Q++ AQ  ++R   +++++   +KE
Sbjct: 1240 YIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKE 1299

Query: 270  -----THTKLALAEARVQEEEQKAT------RLEKELQTQTTKFHQD----QDTIMAKLT 314
                  H    L  ++V+E   +A       +L  E+++    +H +    Q+       
Sbjct: 1300 KDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKI 1359

Query: 315  NEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEE 374
            + DSQ   +QQ    L +   ELEE   ++    +++QD  E I   E  N  ++ + E 
Sbjct: 1360 SADSQKSSVQQLNEQLEKAKLELEEAQDTVSNLHQQVQDRNEVI---EAANEALLTKGEN 1416

Query: 375  L 375
            +
Sbjct: 1417 V 1417


>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
            sapiens]
          Length = 1935

 Score =  115 bits (289), Expect = 2e-25
 Identities = 135/650 (20%), Positives = 282/650 (43%), Gaps = 90/650 (13%)

Query: 217  KEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLAL 276
            K  E+EK + ++KEE T+LK         ++ L  ++    Q+  +L    +     LA 
Sbjct: 841  KSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLAD 900

Query: 277  AEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDE 336
            AE R  +  +   +LE +++    +  +D++ + A+LT   ++ R+L+ + + L R ID+
Sbjct: 901  AEERCDQLIKNKIQLEAKVKEMNERL-EDEEEMNAELT---AKKRKLEDECSELKRDIDD 956

Query: 337  LEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVL--------DMEGKDEE 388
            LE T   + K +   ++  + +++   G   I+A++ + +K +         D++ ++++
Sbjct: 957  LELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDK 1016

Query: 389  L-------IKMEEQCRDLNKRLERETLQSKDFKLEVEKL-------SKRIMALE----KL 430
            +       +K+E+Q  DL   LE+E     D +    KL        + IM LE    +L
Sbjct: 1017 VNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQL 1076

Query: 431  EDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELE-------AIESRLEKTE 483
            ++   K   E  +L   +E E+    QL ++L+ L+ RI+ELE          +++EK  
Sbjct: 1077 DERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLR 1136

Query: 484  FTLKEDLTKLKT-------LTVMFVDERKTMSEKLKKTEDKLQAAS-------------- 522
              L  +L ++          T + ++  K    + +K    L+ A+              
Sbjct: 1137 SDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKH 1196

Query: 523  ----SQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKG 578
                ++L  + + +  V +KL +E         DV   M  + K + +L+   +  E++ 
Sbjct: 1197 ADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQM 1256

Query: 579  NDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKEL-------SQE 631
            N+  S+    +  +  L +      + KL  ++G+ +  L ++   I +L       +Q+
Sbjct: 1257 NEHRSKAEETQRSVNDLTS-----QRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQ 1311

Query: 632  VERLKLKL----KDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKY 687
            +E LK +L    K   A+   L     + + L  +Y  E +    L + L     E+A++
Sbjct: 1312 LEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQW 1371

Query: 688  KLAEKTET--------SHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYM-ATEDLICH 738
            +   +T+           ++ L +RLQE E     ++ +  +L++  H      EDL+  
Sbjct: 1372 RTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVD 1431

Query: 739  LQGDHSVLQKKLNQQENRNRDLG---REIENLTKELERYRHFSKSLRPSL 785
            ++  ++       +Q N ++ L    ++ E    ELE  +  ++SL   L
Sbjct: 1432 VERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTEL 1481



 Score =  107 bits (268), Expect = 5e-23
 Identities = 176/818 (21%), Positives = 352/818 (43%), Gaps = 98/818 (11%)

Query: 82   ELQAR-DEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQRDAFQAKSTPWQEDIYEKPM 140
            ELQAR +E+   L+AE+   A +E     ++ +++ E  +R      +T  Q ++ +K  
Sbjct: 1110 ELQARIEELEEELEAERTARAKVEKLRSDLS-RELEEISERLEEAGGATSVQIEMNKKRE 1168

Query: 141  NELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICLLEQEC 200
             E  K+    +E+  +         K    ++ EL E+    +   +K       LE+E 
Sbjct: 1169 AEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQK-------LEKEK 1221

Query: 201  ERLKKLIDQEIKSQEEKEQEK---EKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQR 257
               K  +D    + E+  + K   EK   TL++++ + +S A    +E QR    LT QR
Sbjct: 1222 SEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKA----EETQRSVNDLTSQR 1277

Query: 258  QKIQ----ELTTNAKETHTKLA-LAEARV---QEEEQKATRLEKELQTQTTKFH------ 303
             K+Q    EL+    E    ++ L   ++   Q+ E    +LE+E++ +    H      
Sbjct: 1278 AKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSAR 1337

Query: 304  QDQDTIMAKLTNEDSQNRQLQQKLAALSRQI---------------DELEETNRSL---- 344
             D D +  +   E     +LQ+ L+  + ++               +ELEE  + L    
Sbjct: 1338 HDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRL 1397

Query: 345  RKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLE 404
            ++AEE ++ +  K S  E     +  E+E+L   ++D+E  +     ++++ R+ +K L 
Sbjct: 1398 QEAEEAVEAVNAKCSSLEKTKHRLQNEIEDL---MVDVERSNAAAAALDKKQRNFDKILA 1454

Query: 405  RETLQSKDFKLEVEKLSKRIMALE----KLEDAFNKSKQECYSLKCNLEKERMTTKQLSQ 460
                + ++ + E+E   K   +L     KL++A+ +S +   + K   +  +     L++
Sbjct: 1455 EWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTE 1514

Query: 461  ELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLK----KTED 516
            +L S    I ELE +  +LE  +  L+  L + +    +  +E K +  +L+    K E 
Sbjct: 1515 QLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEAS--LEHEEGKILRAQLEFNQIKAEI 1572

Query: 517  KLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEE 576
            + + A    ++EQ K   +  ++++  + +L ++T    +   V K+ +   N+++ +  
Sbjct: 1573 ERKLAEKDEEMEQAKRNHL--RVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLS 1630

Query: 577  KGNDLLSRVNMLKNRLQSLEAIEKDFLKN--KLNQDSGKSTTALHQENN----KIKELSQ 630
              N + +        LQSL    +  L +  + N D  ++   + + NN    +++EL  
Sbjct: 1631 HANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRA 1690

Query: 631  EVERLKLKLKDMKAIEDDLMKTEDEYETLERRYA---NERDKAQF----LSKELEHVKME 683
             VE+ +   +  K  E +L++T +  + L  +     N++ K       L  E+E    E
Sbjct: 1691 VVEQTE---RSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQE 1747

Query: 684  LAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDH 743
                +   K   +    + + L++E+  S HL R    +++ I      +DL   L    
Sbjct: 1748 CRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTI------KDLQHRLDEAE 1801

Query: 744  SVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPSLNGRRISDPQVFSKEVQTE 803
             +  K   +Q  +     RE+EN   ELE  +   K    S+ G R S+ ++     QTE
Sbjct: 1802 QIALKGGKKQLQKLEARVRELEN---ELEAEQ---KRNAESVKGMRKSERRIKELTYQTE 1855

Query: 804  AVDNEPPDYKSLIPLERAVINGQLYEESENQDEDPNDE 841
                   D K+L+ L+  V   QL  ++  +  +  +E
Sbjct: 1856 ------EDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEE 1887



 Score =  103 bits (258), Expect = 7e-22
 Identities = 158/739 (21%), Positives = 331/739 (44%), Gaps = 110/739 (14%)

Query: 79   LEGELQARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQRDAFQAKSTPWQEDIYEK 138
            L  E+   DE+I  L  EK   AL EA       ++ L+ LQ +  +  +    +   E+
Sbjct: 978  LTEEMAGLDEIIAKLTKEKK--ALQEAH------QQALDDLQAEEDKVNTLTKAKVKLEQ 1029

Query: 139  PMNELDKVVEKHKE-------SYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDE 191
             +++L+  +E+ K+       + R++ G L + ++S    I++LE +K++  E ++K D 
Sbjct: 1030 QVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQES----IMDLENDKQQLDERLKKKDF 1085

Query: 192  FICLLEQECERLKKLIDQEIKSQ-EEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLT 250
             +  L    E      +Q + SQ ++K +E + R+  L+EEL   ++    V    ++L 
Sbjct: 1086 ELNALNARIED-----EQALGSQLQKKLKELQARIEELEEELEAERTARAKV----EKLR 1136

Query: 251  AQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIM 310
            + L+   ++++E++   +E     ++     ++ E +  ++ ++L+  T +       + 
Sbjct: 1137 SDLS---RELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALR 1193

Query: 311  AKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMA 370
             K  + DS        +A L  QID L+   + L K + E +   + ++          A
Sbjct: 1194 KK--HADS--------VAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKA 1243

Query: 371  EVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVE--KLSKRIMALE 428
             +E++ + + D    +E   K EE  R +N       L S+  KL+ E  +LS+++   E
Sbjct: 1244 NLEKMCRTLEDQ--MNEHRSKAEETQRSVN------DLTSQRAKLQTENGELSRQLDEKE 1295

Query: 429  KLEDAFNKSK----QECYSLKCNLEKERMTTKQLSQELESLK-----VRIKELEAIESR- 478
             L     + K    Q+   LK  LE+E      L+  L+S +     +R +  E  E++ 
Sbjct: 1296 ALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKA 1355

Query: 479  -----LEKTEFTLKEDLTKLKTLTVMFVDE----RKTMSEKLKKTEDKLQAAS---SQLQ 526
                 L K    + +  TK +T  +   +E    +K ++++L++ E+ ++A +   S L+
Sbjct: 1356 ELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLE 1415

Query: 527  VEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTK-------ERDDLKNKLKAEEEKGN 579
              ++++    E L+ + +R+  +   +++K  +  K       + ++ +++L++ +++  
Sbjct: 1416 KTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEAR 1475

Query: 580  DLLSRVNMLKNRL-QSLEAIEKDFLKNK-LNQDSGKSTTALHQENNKIKELSQEVERLKL 637
             L + +  LKN   +SLE +E    +NK L ++    T  L      I EL         
Sbjct: 1476 SLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELE-------- 1527

Query: 638  KLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSH 697
              K  K +E + M+ +   E  E    +E  K      E   +K E+ + KLAEK E   
Sbjct: 1528 --KVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIER-KLAEKDE--- 1581

Query: 698  EQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICH----LQGDHSVLQKKLNQQ 753
                    + E+AK  HL R VD+L+  +     + +        ++GD + ++ +L+  
Sbjct: 1582 --------EMEQAKRNHL-RVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHA 1632

Query: 754  ENRNRDLGREIENLTKELE 772
                 +  +++++L   L+
Sbjct: 1633 NRMAAEAQKQVKSLQSLLK 1651



 Score = 94.0 bits (232), Expect = 7e-19
 Identities = 124/626 (19%), Positives = 267/626 (42%), Gaps = 46/626 (7%)

Query: 63   QAEDLSRDDLLFLLSILEGELQARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQRD 122
            Q EDL R         LE E++A++ +   L++ + D  LL  QY   T  K    LQR 
Sbjct: 1311 QLEDLKRQ--------LEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKA--ELQRV 1360

Query: 123  AFQAKS--TPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKR 180
              +A S    W+   YE    +  + +E+ K+   + L +   A ++       LE+ K 
Sbjct: 1361 LSKANSEVAQWRTK-YETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKH 1419

Query: 181  KHKEYME-------KSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKE---KRVTTLKE 230
            + +  +E       +S+     L+++     K++ +  +  EE + E E   K   +L  
Sbjct: 1420 RLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLST 1479

Query: 231  ELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATR 290
            EL KLK+     ++  +    +    +++I +LT     +   +   E   ++ E +   
Sbjct: 1480 ELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKME 1539

Query: 291  LEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEE 350
            L+  L+        ++  I+      +    ++++KLA    + +E+E+  R+  +  + 
Sbjct: 1540 LQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLA---EKDEEMEQAKRNHLRVVDS 1596

Query: 351  LQDIKEKISKGEYGNAGIMAEVE-ELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQ 409
            LQ   +  ++       +  ++E +L +  + +   +    + ++Q + L   L+   +Q
Sbjct: 1597 LQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQ 1656

Query: 410  SKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRI 469
              D     + L + I  +E+  +      +E   L+  +E+   + K   QEL     R+
Sbjct: 1657 LDDAVRANDDLKENIAIVERRNNLLQAELEE---LRAVVEQTERSRKLAEQELIETSERV 1713

Query: 470  KELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQ 529
            + L +  + L   +  +  DL++L+T     V E +   EK KK        + +L+ EQ
Sbjct: 1714 QLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQ 1773

Query: 530  NKVTTV--TEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNM 587
            +    +   +K +E+T + L+ + D  E++             LK  +++   L +RV  
Sbjct: 1774 DTSAHLERMKKNMEQTIKDLQHRLDEAEQI------------ALKGGKKQLQKLEARVRE 1821

Query: 588  LKNRLQSLEAIEKDFLK--NKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAI 645
            L+N L++ +    + +K   K  +   + T    ++   +  L   V++L+LK+K  K  
Sbjct: 1822 LENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQ 1881

Query: 646  EDDLMKTEDEYETLERRYANERDKAQ 671
             ++  +  +   +  R+  +E D+A+
Sbjct: 1882 AEEAEEQANTNLSKFRKVQHELDEAE 1907



 Score = 84.0 bits (206), Expect = 8e-16
 Identities = 102/500 (20%), Positives = 223/500 (44%), Gaps = 56/500 (11%)

Query: 137  EKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICLL 196
            +K     DK++ + K+ Y     +L  ++K  R    EL + K  ++E +E  + F    
Sbjct: 1443 DKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETF---- 1498

Query: 197  EQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQ 256
                +R  K + +EI    E+     K +  L++   +L++  + +    +   A L  +
Sbjct: 1499 ----KRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHE 1554

Query: 257  RQKIQ----ELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAK 312
              KI     E      E   KLA  +  +++ ++   R+   LQT      + ++  +  
Sbjct: 1555 EGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRV 1614

Query: 313  LTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQ-----------DIKEKISKG 361
                +    +++ +L+  +R   E ++  +SL+   ++ Q           D+KE I+  
Sbjct: 1615 KKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIV 1674

Query: 362  EYGNAGIMAEVEELRKRVLDMEGK----DEELIKMEEQCRDLNKRLERETLQSKDFKLEV 417
            E  N  + AE+EELR  V   E      ++ELI+  E+ + L+ +      Q K    ++
Sbjct: 1675 ERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADL 1734

Query: 418  EKLSKRIM-ALEKLEDAFNKSKQ---ECYSLKCNLEKERMTT-------KQLSQELESLK 466
             +L   +  A+++  +A  K+K+   +   +   L+KE+ T+       K + Q ++ L+
Sbjct: 1735 SQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQ 1794

Query: 467  VRIKELEAI-----ESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLK---KTEDKL 518
             R+ E E I     + +L+K E  ++E   +L+        E+K  +E +K   K+E ++
Sbjct: 1795 HRLDEAEQIALKGGKKQLQKLEARVRELENELEA-------EQKRNAESVKGMRKSERRI 1847

Query: 519  QAASSQLQVEQN---KVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEE 575
            +  + Q + ++    ++  + +KL  + K   +   + EE+  +   +   ++++L   E
Sbjct: 1848 KELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAE 1907

Query: 576  EKGNDLLSRVNMLKNRLQSL 595
            E+ +   S+VN L+ + + +
Sbjct: 1908 ERADIAESQVNKLRAKSRDI 1927



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 116/585 (19%), Positives = 242/585 (41%), Gaps = 79/585 (13%)

Query: 255  LQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLT 314
            L R+ + +L TN + TH         +  E +    ++  L     + +   + I  ++ 
Sbjct: 650  LHRENLNKLMTNLRSTHPHFV--RCIIPNETKSPGVMDNPLVMHQLRCNGVLEGI--RIC 705

Query: 315  NEDSQNRQL----QQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGN----- 365
             +   NR L    +Q+   L+       +   S + AE+ L  +    ++ ++G+     
Sbjct: 706  RKGFPNRILYGDFRQRYRILNPAAIPEGQFIDSRKGAEKLLSSLDIDHNQYKFGHTKVFF 765

Query: 366  -AGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLE-RETLQSKDFKLEVE----- 418
             AG++  +EE+R   L        + +++ Q R +  R+E ++ L+ +D  L ++     
Sbjct: 766  KAGLLGLLEEMRDERLS-----RIITRIQAQSRGVLARMEYKKLLERRDSLLVIQWNIRA 820

Query: 419  ----------KLSKRIMALEKL---EDAFNKSKQECYSLKCNLEKERMTTKQLSQELESL 465
                      KL  +I  L K    E      K+E   LK  LEK     K+L +++ SL
Sbjct: 821  FMGVKNWPWMKLYFKIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSL 880

Query: 466  KVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQL 525
                 +L+      +      +E   +L    +    + K M+E+L+  E+         
Sbjct: 881  LQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEM-------- 932

Query: 526  QVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLK--AEEEKGNDLLS 583
                 ++T    KL +E     +   D+E  +  V KE+   +NK+K   EE  G D   
Sbjct: 933  ---NAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLD--- 986

Query: 584  RVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMK 643
                     + +  + K+  K  L +   ++   L  E +K+  L++   +L+ ++ D++
Sbjct: 987  ---------EIIAKLTKE--KKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLE 1035

Query: 644  AIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFK 703
               +   K   + E  +R+   +    Q    +LE+ K +L +    +  E +    L  
Sbjct: 1036 GSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNA---LNA 1092

Query: 704  RLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGRE 763
            R+++E+A    L +++  L+ +I      E+L   L+ + +   K     E    DL RE
Sbjct: 1093 RIEDEQALGSQLQKKLKELQARI------EELEEELEAERTARAK----VEKLRSDLSRE 1142

Query: 764  IENLTKELERYRHFSKSLRPSLNGRRISDPQVFSKEVQTEAVDNE 808
            +E +++ LE     + S++  +N +R ++ Q   ++++   + +E
Sbjct: 1143 LEEISERLEE-AGGATSVQIEMNKKREAEFQKMRRDLEEATLQHE 1186


>gi|4506751 restin isoform a [Homo sapiens]
          Length = 1427

 Score =  115 bits (287), Expect = 3e-25
 Identities = 175/758 (23%), Positives = 309/758 (40%), Gaps = 171/758 (22%)

Query: 155  RRILGQLLVAE--KSRRQTILELEEEKRKHKEYMEKSDEFICLLEQECERLKKLIDQEIK 212
            R+I G   + E  K ++Q I +L  E+   +  + K+   +  +EQE    +   DQ + 
Sbjct: 345  RKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVL 404

Query: 213  SQEEK-----------EQEKEKRVTTLKEELTKLKSFALMVVDE---QQRLTAQLTLQRQ 258
              E K           ++EK + +  L+EE  K++     V +E   +  L  Q  L+  
Sbjct: 405  ELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHA 464

Query: 259  KIQEL-------TTNAKETHTKLALAEARVQEEEQKATRLEKEL------------QTQT 299
            +I+EL        T A +   +L         E+ +   LEK+L            + ++
Sbjct: 465  RIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLES 524

Query: 300  TKFHQDQDTIMAKLTNEDSQNRQL-------QQKLAALSRQIDELEETNRSLRKAEEELQ 352
             K   D D  ++ L    S   +L       Q+++ +L       EET++   KA   L 
Sbjct: 525  NKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKA---LY 581

Query: 353  DIKEKISKGEYGNAGIMAEVEELRKRVLDM----EGKDEELI-----KMEEQCRDLNKRL 403
               EK+SK    N  + +++E   K   D+    + K E  I      MEE     +K L
Sbjct: 582  TATEKLSK---ENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGL 638

Query: 404  ERETLQSKDFKLEVEKL----------------------SKRIMALE-KLEDAFNKSKQE 440
              ET +  + K ++EK+                      +K + AL  KL     + +  
Sbjct: 639  GTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENS 698

Query: 441  CYSLKCNLEKER----MTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTL 496
              +++  L+K      +  +    +L+  ++++KELE ++++  +    +    ++LK  
Sbjct: 699  LEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKAT 758

Query: 497  TVMFVD---ERKTMSE---KLKKTEDKLQAASSQ---LQVEQN----KVTTVTEKL---- 539
                +D    RK  SE   ++KK   +L+AA  Q   L++E+N    K +++T +L    
Sbjct: 759  EEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRE 818

Query: 540  -------------------IEETKRALKSK-TDVEEKMYSVTKERDDLKNKLKAEEEKGN 579
                               +E+  + LK K  +  E+  SV +   +  NKL  +EE+ N
Sbjct: 819  LKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFN 878

Query: 580  DLLSRVNMLKNRLQSLEA--IEKD-------FLKNKLNQD-------SGKSTTALHQENN 623
             L S +  L+  L  +EA   EKD         K KL  D       SG +++ L + N+
Sbjct: 879  MLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMND 938

Query: 624  KIKELSQEVERLKLKLKD--------MKAIEDDLMKTEDEYETLERRYANERDKAQFLSK 675
            +++   ++VE L+LKL           K+IED  +K E   +   +++  E+       K
Sbjct: 939  ELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEK-------K 991

Query: 676  ELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDL 735
            ELE    +L K     K ETSH Q    + + E A S   ++  + L+      + TED 
Sbjct: 992  ELERKLSDLEK-----KMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTED- 1045

Query: 736  ICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELER 773
                         KL      N  L +E+E L K+ ++
Sbjct: 1046 -------------KLKGAREENSGLLQELEELRKQADK 1070



 Score =  114 bits (284), Expect = 7e-25
 Identities = 151/680 (22%), Positives = 288/680 (42%), Gaps = 93/680 (13%)

Query: 114  KVLEALQRDAFQAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTIL 173
            K +EAL+  A   K    +E+  E   ++LDK  ++H       L +L  AE      + 
Sbjct: 679  KEMEALR--AKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIK----VK 732

Query: 174  ELEEEKRKHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEK---------EKR 224
            ELE  + K  E  +  D F   L+   E+L  L      S E K + K         EK+
Sbjct: 733  ELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQ 792

Query: 225  VTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEE 284
            +  L+ E     S A  +  E Q    +LT  ++ + E++   +    +L + + +  E 
Sbjct: 793  IKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEA 852

Query: 285  EQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSL 344
             ++A  +++ +Q    K HQ ++    +     S   +L++ LA +  +  E +E    L
Sbjct: 853  SEEAVSVQRSMQETVNKLHQKEE----QFNMLSSDLEKLRENLADMEAKFREKDEREEQL 908

Query: 345  RKAEEELQDIKEKISKGEYGNAGIMAEV-EELRKRVLDMEGKDEELIKMEEQCRDLNKRL 403
             KA+E+L++   +I K    N+  + ++ +ELR +  D+E    +L K  E    L K +
Sbjct: 909  IKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSI 968

Query: 404  ERETLQSKDFKLEV-----EKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQL 458
            E  T++++  + E      E+  +    L  LE     S  +C  LK   E+    TK  
Sbjct: 969  EDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTK 1028

Query: 459  SQE-LESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDK 517
             +E L++L+  + + E      +K +   +E+   L+ L            E+L+K  DK
Sbjct: 1029 HEEILQNLQKTLLDTE------DKLKGAREENSGLLQEL------------EELRKQADK 1070

Query: 518  LQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEK 577
             +AA +     Q     + E++ +E    L S  D ++    +  E D LK         
Sbjct: 1071 AKAAQTAEDAMQ-----IMEQMTKEKTETLASLEDTKQTNAKLQNELDTLK--------- 1116

Query: 578  GNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLK- 636
                       +N L+++E +              KS   L  EN K++E  +E+E LK 
Sbjct: 1117 -----------ENNLKNVEEL-------------NKSKELLTVENQKMEEFRKEIETLKQ 1152

Query: 637  ---LKLKDMKAIEDDLMKTEDEY----ETLERRYANERDKAQFLSKELEHVKMELAKYKL 689
                K + + A++++ +K  +E     + +      E +++   ++ LE  K E    K 
Sbjct: 1153 AAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKD 1212

Query: 690  AEKTETSHEQWL---FKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVL 746
            A++ + S ++ +      L E++A+   L  EV  L+ +     +   ++  L+ D   L
Sbjct: 1213 ADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKL 1272

Query: 747  QKKLNQQENRNRDLGREIEN 766
            + K+   E + ++  R++ +
Sbjct: 1273 ELKVKNLELQLKENKRQLSS 1292



 Score = 92.8 bits (229), Expect = 2e-18
 Identities = 151/743 (20%), Positives = 313/743 (42%), Gaps = 82/743 (11%)

Query: 136  YEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHK-EYMEKSDEFIC 194
            +++ +  L +     +E++++ +  L  A +      L  E E  K K E+  K +  + 
Sbjct: 555  HQREITSLKEHFGAREETHQKEIKALYTATEK-----LSKENESLKSKLEHANKENSDVI 609

Query: 195  LLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKS-FALMVVDEQQRLTAQL 253
             L +   +L+  I    ++ EE +    K + T   E  +LK+    M +D Q  +    
Sbjct: 610  ALWKS--KLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIE--- 664

Query: 254  TLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKL 313
             LQ Q+  E   +AKE     A     ++E+E     +  +L     +   + +  + KL
Sbjct: 665  NLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKL 724

Query: 314  TNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQD---IKEKISKGEYGNAGIMA 370
               + + ++L+   A  + Q   ++     L+  EE+L D   +++  S+G+     +  
Sbjct: 725  QEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQ 784

Query: 371  EVEELRKRVLDME-GKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRI-MALE 428
            ++E   K++  +E  K+ E  K     R+L  R E +    ++   EV ++ + +   L+
Sbjct: 785  QLEAAEKQIKHLEIEKNAESSKASSITRELQGR-ELKLTNLQENLSEVSQVKETLEKELQ 843

Query: 429  KLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKE 488
             L++ F ++ +E  S++ ++++   T  +L Q+ E   +   +LE +   L   E   +E
Sbjct: 844  ILKEKFAEASEEAVSVQRSMQE---TVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFRE 900

Query: 489  DLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALK 548
                         DER+   E+L K ++KL+   +++       ++   K+ +E +  LK
Sbjct: 901  K------------DERE---EQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELR--LK 943

Query: 549  SKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLN 608
             + DVEE    +TK  ++     K+ E    D+  +    +         EK  L+ KL+
Sbjct: 944  ER-DVEELQLKLTKANENASFLQKSIE----DMTVKAEQSQQEAAKKHEEEKKELERKLS 998

Query: 609  QDSGKSTTALHQENNKIKELSQEVERLKLKLKD-----MKAIEDDLMKTEDEYETLERRY 663
                K  T+    +N+ +EL    ER   + K      ++ ++  L+ TED+ +      
Sbjct: 999  DLEKKMETS----HNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLK------ 1048

Query: 664  ANERDKAQFLSKELEHVKMELAKYKLAEKTE---------TSHEQWLFKRLQEEEAKSGH 714
               R++   L +ELE ++ +  K K A+  E         T  +      L++ +  +  
Sbjct: 1049 -GAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAK 1107

Query: 715  LSREVDALKE----KIHEYMATEDLIC-------HLQGDHSVLQKKLNQQENRNRDLGRE 763
            L  E+D LKE     + E   +++L+          + +   L++   Q+  +   L  E
Sbjct: 1108 LQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEE 1167

Query: 764  IENLTKELERYRHFSKSLRPSLNGRRISDPQVFSKEVQTEAVDNEPPDYKSLIPLERAV- 822
               L +EL R R    S +     R + + Q+   + +      +  + K+   L++++ 
Sbjct: 1168 NVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKA--SLQKSIS 1225

Query: 823  INGQLYEESENQDEDPNDEGSVL 845
            I   L  E + + E   +E +VL
Sbjct: 1226 ITSALLTEKDAELEKLRNEVTVL 1248



 Score = 81.6 bits (200), Expect = 4e-15
 Identities = 114/566 (20%), Positives = 247/566 (43%), Gaps = 85/566 (15%)

Query: 93   LKAEKMDLALLEAQYGFVTPKKVLEALQRDAFQAKSTPWQEDIYE--KPMNELDKVVEKH 150
            L+A +  +  LE +    + K      +    + K T  QE++ E  +    L+K ++  
Sbjct: 786  LEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQIL 845

Query: 151  KESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICLLEQECERLKK-LIDQ 209
            KE +     + +  ++S ++T+ +L +++ +             +L  + E+L++ L D 
Sbjct: 846  KEKFAEASEEAVSVQRSMQETVNKLHQKEEQFN-----------MLSSDLEKLRENLADM 894

Query: 210  EIKSQEEKEQEKE--KRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNA 267
            E K +E+ E+E++  K    L+ ++ ++   +     +  ++  +L L+ + ++EL    
Sbjct: 895  EAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKL 954

Query: 268  KETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTN----EDSQNRQL 323
             + +   +  +  +++   KA   E+  Q    K  +++  +  KL++     ++ + Q 
Sbjct: 955  TKANENASFLQKSIEDMTVKA---EQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQC 1011

Query: 324  QQKLAALSRQIDELEETNRS-LRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKR---- 378
            Q+  A   R   E +  +   L+  ++ L D ++K+      N+G++ E+EELRK+    
Sbjct: 1012 QELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKA 1071

Query: 379  -----------VLDMEGKDE-ELIKMEEQCRDLNKRLERE--TLQSKDFKLEVEKL--SK 422
                       +++   K++ E +   E  +  N +L+ E  TL+  + K  VE+L  SK
Sbjct: 1072 KAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLK-NVEELNKSK 1130

Query: 423  RIMALE--KLED-----------AFNKSKQECYSLKCNLE--------KERMTTKQ-LSQ 460
             ++ +E  K+E+           A  KS+Q     + N++        ++ +T+ Q L +
Sbjct: 1131 ELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEE 1190

Query: 461  ELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQA 520
            E   L  ++ E++  ES+  K     K  L K  ++T   + E+    EKL+     L+ 
Sbjct: 1191 ERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRG 1250

Query: 521  ASSQLQVEQNKVTTV-------------TEKLIEETKRALKSK-----TDVEEKMYSVTK 562
             ++  +   + V T+              E  ++E KR L S      T  +E   +   
Sbjct: 1251 ENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQES 1310

Query: 563  ERDDLKNKLKAEEEKGNDLLSRVNML 588
            + D L + +   + K  DL  +V M+
Sbjct: 1311 QIDFLNSVIVDLQRKNQDLKMKVEMM 1336



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 116/541 (21%), Positives = 233/541 (43%), Gaps = 100/541 (18%)

Query: 308 TIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDI--KEKISKGEYGN 365
           ++ + +++  S+   L +  +  +R+I        +L++ ++ ++ +  +  + + E   
Sbjct: 321 SVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAK 380

Query: 366 A-GIMAEVEELRKRVLDMEGKDEELIKME---EQCRDLNKRLERETLQSKDFKLEVEKLS 421
           A   + E+E+  +  L  +G D+ ++++E   +Q R + +  +RE ++  + +LE EK  
Sbjct: 381 ATSHVGEIEQ--ELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLN-QLEEEK-- 435

Query: 422 KRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELE-------- 473
                  K+ED           L+  +E+E +T   L  + +    RIKELE        
Sbjct: 436 ------RKVED-----------LQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKT 478

Query: 474 ---AIESRLEKTEF-TLKE-----DLTKLKTLTVMFVDERKTMSEKLKKTED-----KLQ 519
               ++  LE T   T+ E     +L K   L V  V E +   E  K   D      L 
Sbjct: 479 KADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLL 538

Query: 520 AASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEK----MYSVT----KERDDLKNKL 571
              S LQ +     T  ++ I   K    ++ +  +K    +Y+ T    KE + LK+KL
Sbjct: 539 QEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKL 598

Query: 572 KAEEEKGNDLLSRVNMLKNRLQSLEAIEK---DFLKNKLNQDSGKSTTALHQENNKIKEL 628
           +   ++ +D+++   + K++L++  A  +   + LK   ++  G  T    +   +I+++
Sbjct: 599 EHANKENSDVIA---LWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKM 655

Query: 629 ----SQEVERLK--------LKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKE 676
                 E+E L+           K+M+A+   LMK   E E       ++ DKA+    +
Sbjct: 656 RLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAE----D 711

Query: 677 LEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLI 736
              V+ME    KL E       +   K L+  +AK    ++ +D    ++    ATE+ +
Sbjct: 712 QHLVEMEDTLNKLQE------AEIKVKELEVLQAKCNEQTKVIDNFTSQL---KATEEKL 762

Query: 737 CHLQGDHSVLQKKLNQQENRNRDLGREIENLTK-----ELERYRHFSK--SLRPSLNGRR 789
                D   L+K  ++ ++  + L +++E   K     E+E+    SK  S+   L GR 
Sbjct: 763 L----DLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRE 818

Query: 790 I 790
           +
Sbjct: 819 L 819


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.309    0.125    0.335 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,522,687
Number of Sequences: 37866
Number of extensions: 2078014
Number of successful extensions: 31185
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 540
Number of HSP's successfully gapped in prelim test: 1490
Number of HSP's that attempted gapping in prelim test: 10346
Number of HSP's gapped (non-prelim): 8471
length of query: 1133
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1020
effective length of database: 13,968,660
effective search space: 14248033200
effective search space used: 14248033200
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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