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Search of human proteins with 109637791
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|109637791 transcription factor-like nuclear regulator [Homo
sapiens]
(2624 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|109637791 transcription factor-like nuclear regulator [Homo s... 5137 0.0
gi|71061468 centromere protein E [Homo sapiens] 118 9e-26
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 95 8e-19
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 87 2e-16
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 81 2e-14
gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens] 79 6e-14
gi|118498368 kinectin 1 isoform c [Homo sapiens] 79 8e-14
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap... 78 1e-13
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 78 1e-13
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 77 3e-13
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 76 5e-13
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 76 5e-13
gi|221219020 NYD-SP11 protein [Homo sapiens] 75 7e-13
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 75 9e-13
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 75 9e-13
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 75 9e-13
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 75 9e-13
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 75 9e-13
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 75 9e-13
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 75 9e-13
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 75 9e-13
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 75 9e-13
gi|118498356 kinectin 1 isoform a [Homo sapiens] 74 1e-12
gi|33620775 kinectin 1 isoform a [Homo sapiens] 74 1e-12
gi|153945728 microtubule-associated protein 1B [Homo sapiens] 74 1e-12
gi|156104874 envoplakin [Homo sapiens] 74 2e-12
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 74 2e-12
gi|148746195 trichohyalin [Homo sapiens] 74 2e-12
gi|33620716 retinoblastoma-binding protein 6 isoform 2 [Homo sap... 73 4e-12
gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo sap... 73 4e-12
>gi|109637791 transcription factor-like nuclear regulator [Homo
sapiens]
Length = 2624
Score = 5137 bits (13325), Expect = 0.0
Identities = 2624/2624 (100%), Positives = 2624/2624 (100%)
Query: 1 MFRRARLSVKPNVRPGVGARGSTASNPQRGRESPRPPDPATDSASKPAEPTDVPTVDFGG 60
MFRRARLSVKPNVRPGVGARGSTASNPQRGRESPRPPDPATDSASKPAEPTDVPTVDFGG
Sbjct: 1 MFRRARLSVKPNVRPGVGARGSTASNPQRGRESPRPPDPATDSASKPAEPTDVPTVDFGG 60
Query: 61 AEPQEKAPRSSTEKTGGDNDVEESSRSSSTVSQRRKRISSTSSLVKSSVSVPSESHPLST 120
AEPQEKAPRSSTEKTGGDNDVEESSRSSSTVSQRRKRISSTSSLVKSSVSVPSESHPLST
Sbjct: 61 AEPQEKAPRSSTEKTGGDNDVEESSRSSSTVSQRRKRISSTSSLVKSSVSVPSESHPLST 120
Query: 121 INQEAPQPTATSTKEKQPCSDRYRIYKAQKLREMLKEELRKEKKQWKNKYAINESQRPPD 180
INQEAPQPTATSTKEKQPCSDRYRIYKAQKLREMLKEELRKEKKQWKNKYAINESQRPPD
Sbjct: 121 INQEAPQPTATSTKEKQPCSDRYRIYKAQKLREMLKEELRKEKKQWKNKYAINESQRPPD 180
Query: 181 RSKMTMRDFIYYLPDNNPMTSSLEQEKKTEKPSTPVQTREQEGKSTPNAEDNEMEEETDD 240
RSKMTMRDFIYYLPDNNPMTSSLEQEKKTEKPSTPVQTREQEGKSTPNAEDNEMEEETDD
Sbjct: 181 RSKMTMRDFIYYLPDNNPMTSSLEQEKKTEKPSTPVQTREQEGKSTPNAEDNEMEEETDD 240
Query: 241 GPLLVPRVKVAEDGSIILDEESLTVEVLRTKGPCVVEENDPIFERGSTTTYSSFRKNYYS 300
GPLLVPRVKVAEDGSIILDEESLTVEVLRTKGPCVVEENDPIFERGSTTTYSSFRKNYYS
Sbjct: 241 GPLLVPRVKVAEDGSIILDEESLTVEVLRTKGPCVVEENDPIFERGSTTTYSSFRKNYYS 300
Query: 301 KPWSNKETDMFFLAISMVGTDFSMIGQLFPHRARIEIKNKFKREEKTNGWRIDKAFQEKR 360
KPWSNKETDMFFLAISMVGTDFSMIGQLFPHRARIEIKNKFKREEKTNGWRIDKAFQEKR
Sbjct: 301 KPWSNKETDMFFLAISMVGTDFSMIGQLFPHRARIEIKNKFKREEKTNGWRIDKAFQEKR 360
Query: 361 PFDFDFFAHLLQKVLAEEEKRKQKSVKNHSLKEKKSTKPRKNVKVKKVACEGVNNDPDES 420
PFDFDFFAHLLQKVLAEEEKRKQKSVKNHSLKEKKSTKPRKNVKVKKVACEGVNNDPDES
Sbjct: 361 PFDFDFFAHLLQKVLAEEEKRKQKSVKNHSLKEKKSTKPRKNVKVKKVACEGVNNDPDES 420
Query: 421 MSSRISDTERSQKDAQTVEEESLTLSREDAEQVALEVDLNQKKRRRKKQDGANELGVNNL 480
MSSRISDTERSQKDAQTVEEESLTLSREDAEQVALEVDLNQKKRRRKKQDGANELGVNNL
Sbjct: 421 MSSRISDTERSQKDAQTVEEESLTLSREDAEQVALEVDLNQKKRRRKKQDGANELGVNNL 480
Query: 481 LENATVQAGPSKGEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGIVGFASTEKVEKRT 540
LENATVQAGPSKGEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGIVGFASTEKVEKRT
Sbjct: 481 LENATVQAGPSKGEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGIVGFASTEKVEKRT 540
Query: 541 DPILSLSNQQDATSVATESSESSTSDLPSFEVGIRALCEVNNAEGSCIEERNVDLKNNSL 600
DPILSLSNQQDATSVATESSESSTSDLPSFEVGIRALCEVNNAEGSCIEERNVDLKNNSL
Sbjct: 541 DPILSLSNQQDATSVATESSESSTSDLPSFEVGIRALCEVNNAEGSCIEERNVDLKNNSL 600
Query: 601 EIDQTENVKPMLRGRFQRPKPNLSRAGKKSVLSQGKTESESKNSHSKTSVEKNHVEKDKM 660
EIDQTENVKPMLRGRFQRPKPNLSRAGKKSVLSQGKTESESKNSHSKTSVEKNHVEKDKM
Sbjct: 601 EIDQTENVKPMLRGRFQRPKPNLSRAGKKSVLSQGKTESESKNSHSKTSVEKNHVEKDKM 660
Query: 661 NTLDILRMETTERENPEAETVSVLGEKNCLQEGSQLKALRPVQVRGRLQKPKPNAGKAAE 720
NTLDILRMETTERENPEAETVSVLGEKNCLQEGSQLKALRPVQVRGRLQKPKPNAGKAAE
Sbjct: 661 NTLDILRMETTERENPEAETVSVLGEKNCLQEGSQLKALRPVQVRGRLQKPKPNAGKAAE 720
Query: 721 RKEILISQEEIGANVEKNENESCADRDTPQHMEDQSRKDFEEEDVILQPEKNDSFQNVQP 780
RKEILISQEEIGANVEKNENESCADRDTPQHMEDQSRKDFEEEDVILQPEKNDSFQNVQP
Sbjct: 721 RKEILISQEEIGANVEKNENESCADRDTPQHMEDQSRKDFEEEDVILQPEKNDSFQNVQP 780
Query: 781 DEPKVLNECLSVQENNKANKLNQVPILRTRFQKPKPNIGRGTGRREISSKEEVLEKILVS 840
DEPKVLNECLSVQENNKANKLNQVPILRTRFQKPKPNIGRGTGRREISSKEEVLEKILVS
Sbjct: 781 DEPKVLNECLSVQENNKANKLNQVPILRTRFQKPKPNIGRGTGRREISSKEEVLEKILVS 840
Query: 841 GEMAAALRETVRLDTSPKEMVPAEINTKEMQSDLKETGRRAISPREKILDVIDDTIEMET 900
GEMAAALRETVRLDTSPKEMVPAEINTKEMQSDLKETGRRAISPREKILDVIDDTIEMET
Sbjct: 841 GEMAAALRETVRLDTSPKEMVPAEINTKEMQSDLKETGRRAISPREKILDVIDDTIEMET 900
Query: 901 GLKAMGREICLREKTPEVIDATEEIDKDLEEAGRREISPQKNGPEEVKPLGEVETDLKAT 960
GLKAMGREICLREKTPEVIDATEEIDKDLEEAGRREISPQKNGPEEVKPLGEVETDLKAT
Sbjct: 901 GLKAMGREICLREKTPEVIDATEEIDKDLEEAGRREISPQKNGPEEVKPLGEVETDLKAT 960
Query: 961 GNESSPREKTPEVTDATEEIDKNLEETGRRKISPRENGPEEVKPVDEMETDLNATGRESS 1020
GNESSPREKTPEVTDATEEIDKNLEETGRRKISPRENGPEEVKPVDEMETDLNATGRESS
Sbjct: 961 GNESSPREKTPEVTDATEEIDKNLEETGRRKISPRENGPEEVKPVDEMETDLNATGRESS 1020
Query: 1021 PREKTPEVIDATEEIDLEETEREVSPQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEV 1080
PREKTPEVIDATEEIDLEETEREVSPQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEV
Sbjct: 1021 PREKTPEVIDATEEIDLEETEREVSPQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEV 1080
Query: 1081 IDAIEEIEIDLEETEREISPQENGLEEVKPLGEMQTDLKATGREISPREKTPEVIDATEE 1140
IDAIEEIEIDLEETEREISPQENGLEEVKPLGEMQTDLKATGREISPREKTPEVIDATEE
Sbjct: 1081 IDAIEEIEIDLEETEREISPQENGLEEVKPLGEMQTDLKATGREISPREKTPEVIDATEE 1140
Query: 1141 IDKDLEETGRREISPEENGPEEVKPVDEMETDLKTTGREGSSREKTREVIDAAEVIETDL 1200
IDKDLEETGRREISPEENGPEEVKPVDEMETDLKTTGREGSSREKTREVIDAAEVIETDL
Sbjct: 1141 IDKDLEETGRREISPEENGPEEVKPVDEMETDLKTTGREGSSREKTREVIDAAEVIETDL 1200
Query: 1201 EETEREISPQENGPEEVKPVGKMETDLKEIREEISQREKVLAEFSAIREKEIDLKETGKR 1260
EETEREISPQENGPEEVKPVGKMETDLKEIREEISQREKVLAEFSAIREKEIDLKETGKR
Sbjct: 1201 EETEREISPQENGPEEVKPVGKMETDLKEIREEISQREKVLAEFSAIREKEIDLKETGKR 1260
Query: 1261 DIPIMEKVSGKMAVVEEMEADLKETGKENFRERGSEEICVTEEKVAELKQTGKTDISPRE 1320
DIPIMEKVSGKMAVVEEMEADLKETGKENFRERGSEEICVTEEKVAELKQTGKTDISPRE
Sbjct: 1261 DIPIMEKVSGKMAVVEEMEADLKETGKENFRERGSEEICVTEEKVAELKQTGKTDISPRE 1320
Query: 1321 NELEETSTSRQTDTHLMQSGSNDFSAVPSLDIQNISSEVLSMMHTPVEEKRNSEKEVSSH 1380
NELEETSTSRQTDTHLMQSGSNDFSAVPSLDIQNISSEVLSMMHTPVEEKRNSEKEVSSH
Sbjct: 1321 NELEETSTSRQTDTHLMQSGSNDFSAVPSLDIQNISSEVLSMMHTPVEEKRNSEKEVSSH 1380
Query: 1381 FSHFKISSQTHESDKTEVQGIQSPDVPEQFSDINLSKSLPQEQKPLEIKPAPFVRSRFKR 1440
FSHFKISSQTHESDKTEVQGIQSPDVPEQFSDINLSKSLPQEQKPLEIKPAPFVRSRFKR
Sbjct: 1381 FSHFKISSQTHESDKTEVQGIQSPDVPEQFSDINLSKSLPQEQKPLEIKPAPFVRSRFKR 1440
Query: 1441 PKPNLARAALKRETTESEKYIYEKKSETKKMETIVMQENNEQTDTLPSQHDEASLMISRE 1500
PKPNLARAALKRETTESEKYIYEKKSETKKMETIVMQENNEQTDTLPSQHDEASLMISRE
Sbjct: 1441 PKPNLARAALKRETTESEKYIYEKKSETKKMETIVMQENNEQTDTLPSQHDEASLMISRE 1500
Query: 1501 KDTLGHRNEEAVILPCTQTERNLSPSNSCEPKEESQSAPVQKNDSVVSVGTNNVNTFQQE 1560
KDTLGHRNEEAVILPCTQTERNLSPSNSCEPKEESQSAPVQKNDSVVSVGTNNVNTFQQE
Sbjct: 1501 KDTLGHRNEEAVILPCTQTERNLSPSNSCEPKEESQSAPVQKNDSVVSVGTNNVNTFQQE 1560
Query: 1561 MKESVIQTARQVRGRLQRPRPNIRKTGQRQIVDKGEAKGIIKEGRTILPKDETEKKVLTV 1620
MKESVIQTARQVRGRLQRPRPNIRKTGQRQIVDKGEAKGIIKEGRTILPKDETEKKVLTV
Sbjct: 1561 MKESVIQTARQVRGRLQRPRPNIRKTGQRQIVDKGEAKGIIKEGRTILPKDETEKKVLTV 1620
Query: 1621 SNSQIETEIEVPSSAVPEHRMYENQSQVVLVENLHVNKTNETIRHENKPYVPSSAQMTRR 1680
SNSQIETEIEVPSSAVPEHRMYENQSQVVLVENLHVNKTNETIRHENKPYVPSSAQMTRR
Sbjct: 1621 SNSQIETEIEVPSSAVPEHRMYENQSQVVLVENLHVNKTNETIRHENKPYVPSSAQMTRR 1680
Query: 1681 KFQKAKPNLGRAHSKKEEPVLEKVTTDQSKEGKPEDHLLQKGASNTQLLLKEKAELLTSL 1740
KFQKAKPNLGRAHSKKEEPVLEKVTTDQSKEGKPEDHLLQKGASNTQLLLKEKAELLTSL
Sbjct: 1681 KFQKAKPNLGRAHSKKEEPVLEKVTTDQSKEGKPEDHLLQKGASNTQLLLKEKAELLTSL 1740
Query: 1741 EVSARKDCVGSKESALAKIDAELEEVGPSRRVGEETVGDNSPSSVVEEQYLNKLTSCPQP 1800
EVSARKDCVGSKESALAKIDAELEEVGPSRRVGEETVGDNSPSSVVEEQYLNKLTSCPQP
Sbjct: 1741 EVSARKDCVGSKESALAKIDAELEEVGPSRRVGEETVGDNSPSSVVEEQYLNKLTSCPQP 1800
Query: 1801 LNETSYSKIALDGKTTISSTSEYERNRGERRSHKKFKPNVTRGRGSKRVRGKTSKKEPRA 1860
LNETSYSKIALDGKTTISSTSEYERNRGERRSHKKFKPNVTRGRGSKRVRGKTSKKEPRA
Sbjct: 1801 LNETSYSKIALDGKTTISSTSEYERNRGERRSHKKFKPNVTRGRGSKRVRGKTSKKEPRA 1860
Query: 1861 SKAMLVTLRASQEEDDDADDFESDYEEESYHLAPEEVNKAPVFVPVGLRSPEPVSAQIEE 1920
SKAMLVTLRASQEEDDDADDFESDYEEESYHLAPEEVNKAPVFVPVGLRSPEPVSAQIEE
Sbjct: 1861 SKAMLVTLRASQEEDDDADDFESDYEEESYHLAPEEVNKAPVFVPVGLRSPEPVSAQIEE 1920
Query: 1921 TMEELEITVNVPDVGCIAVVEHELPNTDVTTEEMKQEENLSVPFEMTTSEHIQDEPGTND 1980
TMEELEITVNVPDVGCIAVVEHELPNTDVTTEEMKQEENLSVPFEMTTSEHIQDEPGTND
Sbjct: 1921 TMEELEITVNVPDVGCIAVVEHELPNTDVTTEEMKQEENLSVPFEMTTSEHIQDEPGTND 1980
Query: 1981 GSTEAAITLLTMGDLVLQSEISSEQGDVGVCIIPHVHSKDKSHIPSSLDNVNHKIVHECQ 2040
GSTEAAITLLTMGDLVLQSEISSEQGDVGVCIIPHVHSKDKSHIPSSLDNVNHKIVHECQ
Sbjct: 1981 GSTEAAITLLTMGDLVLQSEISSEQGDVGVCIIPHVHSKDKSHIPSSLDNVNHKIVHECQ 2040
Query: 2041 ELSSPVITTSPASFEENKIVLEEQSSREEISLMEKVKENATPTRNTISKVTSNLRIRSRL 2100
ELSSPVITTSPASFEENKIVLEEQSSREEISLMEKVKENATPTRNTISKVTSNLRIRSRL
Sbjct: 2041 ELSSPVITTSPASFEENKIVLEEQSSREEISLMEKVKENATPTRNTISKVTSNLRIRSRL 2100
Query: 2101 AKPKPNLEKTLGTNRLDDYQEVSSLCVTKGAEMETQRETEKNASKATELENKNLGPVTTA 2160
AKPKPNLEKTLGTNRLDDYQEVSSLCVTKGAEMETQRETEKNASKATELENKNLGPVTTA
Sbjct: 2101 AKPKPNLEKTLGTNRLDDYQEVSSLCVTKGAEMETQRETEKNASKATELENKNLGPVTTA 2160
Query: 2161 ENKDQSKLACVHGIKGTSISSEVNLTERNENQEESSQEVHMLSVAPVASSETGPCTLGLD 2220
ENKDQSKLACVHGIKGTSISSEVNLTERNENQEESSQEVHMLSVAPVASSETGPCTLGLD
Sbjct: 2161 ENKDQSKLACVHGIKGTSISSEVNLTERNENQEESSQEVHMLSVAPVASSETGPCTLGLD 2220
Query: 2221 RGLGENSVEEPQIKDSKGDSVLTLPVPEYTPTSIPEVQQENIINPQDLTVNLVANVPQDG 2280
RGLGENSVEEPQIKDSKGDSVLTLPVPEYTPTSIPEVQQENIINPQDLTVNLVANVPQDG
Sbjct: 2221 RGLGENSVEEPQIKDSKGDSVLTLPVPEYTPTSIPEVQQENIINPQDLTVNLVANVPQDG 2280
Query: 2281 EDEQAFILTLVEIPANAVEEFTDATAQFMPNPLLPAPILVKSVNTEERGDMSICLPATSV 2340
EDEQAFILTLVEIPANAVEEFTDATAQFMPNPLLPAPILVKSVNTEERGDMSICLPATSV
Sbjct: 2281 EDEQAFILTLVEIPANAVEEFTDATAQFMPNPLLPAPILVKSVNTEERGDMSICLPATSV 2340
Query: 2341 GQDAMGLSISGRDNSKKPPDNLDLVSRKRFQCRLDKNDHIPPAKKRSLTLRDDCQEYTTE 2400
GQDAMGLSISGRDNSKKPPDNLDLVSRKRFQCRLDKNDHIPPAKKRSLTLRDDCQEYTTE
Sbjct: 2341 GQDAMGLSISGRDNSKKPPDNLDLVSRKRFQCRLDKNDHIPPAKKRSLTLRDDCQEYTTE 2400
Query: 2401 VHSKELTNVFEETGESHKGQDIFLTSGSTLTTPEPQRQQVEAAFQSRGSRSPDACMDKNV 2460
VHSKELTNVFEETGESHKGQDIFLTSGSTLTTPEPQRQQVEAAFQSRGSRSPDACMDKNV
Sbjct: 2401 VHSKELTNVFEETGESHKGQDIFLTSGSTLTTPEPQRQQVEAAFQSRGSRSPDACMDKNV 2460
Query: 2461 PQLPQDEMIVSDKEERTDAAPKSQQMDSRTSSSKASLSRPGRRPLGFLSLICSKNSLESD 2520
PQLPQDEMIVSDKEERTDAAPKSQQMDSRTSSSKASLSRPGRRPLGFLSLICSKNSLESD
Sbjct: 2461 PQLPQDEMIVSDKEERTDAAPKSQQMDSRTSSSKASLSRPGRRPLGFLSLICSKNSLESD 2520
Query: 2521 EPMQVHSKKRLKPLIPGLRKKLKRSNPFNESQEKNRESSDLLPSPSVITTQSENISSSAT 2580
EPMQVHSKKRLKPLIPGLRKKLKRSNPFNESQEKNRESSDLLPSPSVITTQSENISSSAT
Sbjct: 2521 EPMQVHSKKRLKPLIPGLRKKLKRSNPFNESQEKNRESSDLLPSPSVITTQSENISSSAT 2580
Query: 2581 QVSCDQPLLKEGYKSAQKRAPQGEATTVSEYFFNDIFIEVDETE 2624
QVSCDQPLLKEGYKSAQKRAPQGEATTVSEYFFNDIFIEVDETE
Sbjct: 2581 QVSCDQPLLKEGYKSAQKRAPQGEATTVSEYFFNDIFIEVDETE 2624
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 118 bits (295), Expect = 9e-26
Identities = 295/1507 (19%), Positives = 620/1507 (41%), Gaps = 153/1507 (10%)
Query: 371 LQKVLAEEEKRKQKSVKNHSLKEKKST--KPRKNVKVKKVACEGVNNDPDESMSSRISDT 428
L K + E E +++ + LK S + RK ++ K + ++ D+ S +
Sbjct: 729 LNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKE 788
Query: 429 ERSQ----------KDAQTVEEESLTLSREDAEQVALEVDLNQKKRRRKKQDGANELGVN 478
R Q D T + + +E L +D QK + +++ +
Sbjct: 789 SRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIV 848
Query: 479 NLLENATV---QAGPSKGE------KHKNKCQAIRPELKEGECSKEQMLSCTQNIDGIVG 529
NL + A G K E + + K + ++ L E E KEQ+ + + +
Sbjct: 849 NLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVER 908
Query: 530 FAS--TEKVEKRTDPILSLSNQQDATSVATESSESSTSDLPS-----FEVGIRALCEVNN 582
+ TEK+++ + + +L+ ++D ES + L S + I ++ N
Sbjct: 909 EKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRN 968
Query: 583 AEGSCIEERNVDLKNNSLEIDQTENVKPMLRGRFQRPKPNLSRAGKKSVLSQGKTESESK 642
A S + + N+L+ +E V L + +K V K + E+K
Sbjct: 969 ALESLKQHQETI---NTLKSKISEEVSRNLHME-ENTGETKDEFQQKMVGIDKKQDLEAK 1024
Query: 643 NSHSKTS-VEKNHVEKDKMNTLDILRMETTERENPEAETVSVLGEKNCLQEGSQLKALRP 701
N+ + T+ V+ N + + + +++ E+ + SV+ EK L+ + LK
Sbjct: 1025 NTQTLTADVKDNEIIEQQRKIFSLIQ----EKNELQQMLESVIAEKEQLK--TDLK--EN 1076
Query: 702 VQVRGRLQKPKPNAGKAAERKEILISQEEIGANVEKNENESCADR--DTPQHMEDQSRKD 759
+++ Q+ G ++++ +++QE+ A ++ E DR + + ++++S++
Sbjct: 1077 IEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQL 1136
Query: 760 FEEEDVILQPEKNDSFQNVQPDEPKVLNECLSVQENNKANKLNQVPILRTRFQKPKPNIG 819
E++ +L ++ S + K +NE +++ K +L + R + +
Sbjct: 1137 QEKQQQLLNVQEEMS------EMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNE 1190
Query: 820 RGTGRREISSKEEVLEKILVSGE-----MAAALRETVRLDTSPKEMVP-AEINTKEMQSD 873
+ I+ + +VL+++ S E + +RE KE + A I+ KE Q
Sbjct: 1191 NYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQET 1250
Query: 874 LKETGRRAISPREKILDVIDDTIEMETGLKAMGREICLREKTPEVIDATEEIDKDLEEAG 933
+ E RR++S EK +I+ T ++E + EI + + E++ +E+ + E
Sbjct: 1251 IDEL-RRSVS--EKTAQIIN-TQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMN 1306
Query: 934 RREISPQKNGPEEVKPLGEVETDLKATGNESSPREKTPEVTDATEEID--KNLEETGRRK 991
E+ +++ ++ L +E + + NE +E E+ T+E D K ++E K
Sbjct: 1307 ELELLTEQSTTKDSTTLARIEME-RLRLNEKF-QESQEEIKSLTKERDNLKTIKEALEVK 1364
Query: 992 ISP-RENGPEEVKPVDEMETDLNATGRESSPREKTPEVIDATEEIDLEETER-EVSPQEN 1049
+E+ E + + E ++ + +T +++ E+ +++ + +
Sbjct: 1365 HDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEML 1424
Query: 1050 GLEEVKPLGEMETDLKATGRDSFPRGKTPEVIDA--------IEEIEIDLEETEREISPQ 1101
GL K L E ++K+ ++ + EV+ + I+EI ETE E+
Sbjct: 1425 GLS--KRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVA 1482
Query: 1102 ENGL-EEVKPLGEMQTDLKATGREISPREKTPEVIDATEEIDKDLEETGRREISPEENGP 1160
L E+ + + E++ +L EIS +K E I+ +++ ++E +E E+
Sbjct: 1483 HCCLKEQEETINELRVNLSEKETEISTIQKQLEAIN--DKLQNKIQEIYEKE---EQFNI 1537
Query: 1161 EEVKPVDEMETDLKTTGREGSSREKTREVIDAAEVIETD-LEETEREISPQENGPEEVKP 1219
+++ V E +LK +++ + I++ + T+ L+E++ EI EE+K
Sbjct: 1538 KQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMK- 1596
Query: 1220 VGKMETDLKEIREEISQREK-VLAEFSAIREKEID-LKETGKRDIPIMEKVSGKMAVVEE 1277
+++ L+ R+++ + K ++A+ +EKE LK T + + KM +E
Sbjct: 1597 --RVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTA------VNETQEKMCEIEH 1648
Query: 1278 MEADLKETGKENFRERGSEEICVTE---EKVAELKQTGKTDISPRENELEETSTSRQTDT 1334
++ ET K N +E I +T+ E + E++ K R E Q
Sbjct: 1649 LKEQF-ETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKE 1707
Query: 1335 HLMQSGSNDFSAVPSLDIQNIS----SEVLSMMHTPVEEKRNSEKEVSSHFSHFKISSQT 1390
+L ++ + D L I ++ E + + V EK N + H + +
Sbjct: 1708 NLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKA 1767
Query: 1391 HESDKTEVQGIQSPDVPEQFSDINLSKSLPQE--------QKPLEIKPAPFVRSRFKRPK 1442
+ E I + EQ I+ + + E QK LE A ++ + + K
Sbjct: 1768 QDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAK-LQEKIQELK 1826
Query: 1443 PNLARA-ALKRETTESEKYIYEK---KSETKKMETIVMQENNEQTDTLPSQHDEASLM-- 1496
N + LK++ E++K + E K + K + + E + H+ M
Sbjct: 1827 ANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKS 1886
Query: 1497 ISREKDTLGHRNEEAVILPCTQTERNLSPSNS--CEPKEESQSAPVQKNDSVVSVGTNNV 1554
+ +E+D L R EE + L Q + +L + + E ++E ++A + + V
Sbjct: 1887 VMKERDNL-RRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEH-----KETV 1940
Query: 1555 NTFQQEMKESVIQTARQVRGRLQRPRPNIRKTGQRQIVDKGEAKGI-IKEGRTILPKDET 1613
+ ++++ E IQ + ++ L + + ++K Q + K E + + +KE + K
Sbjct: 1941 DKLREKISEKTIQIS-DIQKDLDKSKDELQKKIQE--LQKKELQLLRVKEDVNMSHKKIN 1997
Query: 1614 EKKVLTVSNSQIETEIEVPSSAVPEHRMYENQSQVVLVENLHVNKTNETIRHENKPYVPS 1673
E + Q++ + E + ++ RM Q L + LH ++ E IR K
Sbjct: 1998 EME-------QLKKQFEAQNLSMQSVRMDNFQ----LTKKLH--ESLEEIRIVAKE---- 2040
Query: 1674 SAQMTRRKFQKAKPNLGRAHSKKEEPVLEKVTTD-QSKEGKPEDHLLQKGASNTQLLLKE 1732
R + ++ K +L + + E + D Q+ + KPE LL G + L+E
Sbjct: 2041 -----RDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLRE 2095
Query: 1733 KAELLTSLEVSARKDCVGSKESALAKIDAELEEVGPSRRVGEETVGDNSPSSVVEEQYLN 1792
K + E+ R + L ++ +LE+ ++ V N ++ +++
Sbjct: 2096 KCSRIK--ELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIE 2153
Query: 1793 KLTSCPQ 1799
KL + Q
Sbjct: 2154 KLFTANQ 2160
Score = 94.4 bits (233), Expect = 1e-18
Identities = 292/1549 (18%), Positives = 606/1549 (39%), Gaps = 211/1549 (13%)
Query: 327 QLFPHRARIEIKNKFKREEKTNGWRIDKAFQEKRPFDFDFFAHLLQKVLAEEEKRKQKSV 386
QL + +E+K K K + +D+ +R D L+ ++ + K V
Sbjct: 516 QLRTEKEEMELKLKEKND-------LDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEV 568
Query: 387 KNHSLKEKKSTKPR----KNVKVKKVACEGVNNDPDESMSSRISDTERSQKDAQTVEEES 442
N L+ + S+K K ++KK+ E +++ E++ +S + S +D + +++
Sbjct: 569 YNQDLENELSSKVELLREKEDQIKKLQ-EYIDSQKLENIKMDLSYSLESIEDPKQMKQTL 627
Query: 443 LTLSREDAEQVALEVDLNQKKRRRKK---QDGANELGVNNLLENATVQAGPSKGEKHKNK 499
DAE VAL+ R + ++ EL +Q S+ E K
Sbjct: 628 F-----DAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKM 682
Query: 500 CQAIRPELKEGECSKEQMLSCTQNIDGIVG---FASTEKVEKRTDPILSLSNQQDATSVA 556
+ EL+ + ++ T IDG V + E K TD L+ + +
Sbjct: 683 QVDLEKELQS---AFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEAL 739
Query: 557 TESSE--SSTSDLPSFEVGIRALCEVNNAEGSCIEERNVDLKNNSLEIDQTENVKPMLRG 614
E S LPS EV I++++ +L + E D+ +
Sbjct: 740 REEVILLSELKSLPS---------EVERLRKE-IQDKSEELHIITSEKDKLFSEVVHKES 789
Query: 615 RFQRPKPNLSRAGKKSVLSQGKTESESKNSHSKTSVEKNHVEKDKMNTLDILRMETTERE 674
R Q + + +Q +S + + ++ + +K KM +E ER
Sbjct: 790 RVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMV------LEENERM 843
Query: 675 NPEAETVSVLGEKNCLQEGSQLKALRPVQVRGRLQKPKPNAGKAAERKEILISQEEIGAN 734
N E +S K + S L AL+ ++ + Q+ + K E +E L E++
Sbjct: 844 NQEIVNLS----KEAQKFDSSLGALK-TELSYKTQELQE---KTREVQERLNEMEQLKEQ 895
Query: 735 VEKNENESCADRDTPQHMEDQSRKDFEEEDVILQPEKNDSFQNVQPDEPKVLNECLSVQE 794
+E ++ + ++ ++ EE + Q + D+ K L E L ++
Sbjct: 896 LENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQ----------EKDDLKQLQESLQIER 945
Query: 795 NNKANKLNQVPILRTRFQKPKPNIGRGTGRREISS---KEEVLEKILVSGEMAAALRETV 851
+ + ++ + Q+ N + + + K ++ E++ + M ET
Sbjct: 946 DQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETK 1005
Query: 852 RLDTSPKEMVPAEI-------NTKEMQSDLKETGRRAISPREKILDVIDDTIEMETGLKA 904
D ++MV + NT+ + +D+K+ I + KI +I + E++ L++
Sbjct: 1006 --DEFQQKMVGIDKKQDLEAKNTQTLTADVKDN--EIIEQQRKIFSLIQEKNELQQMLES 1061
Query: 905 MGREICLREKTPEVIDATEEIDKDLEEAGRREISPQKNGPEEVKPLGEVETDLKATGNES 964
+ + EK D E I+ +E + + ++ E +K G S
Sbjct: 1062 V-----IAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELS 1116
Query: 965 SPREKTPEVTDATEEIDKNLEETGRRKISPRENGPEEVKPVDEMETDLNATGRESSPREK 1024
++ EV + +E + L+E ++ ++ +E E K ++E+E N E +E
Sbjct: 1117 RTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKN----ELKNKEL 1172
Query: 1025 TPEVIDATEEIDLE-------ETEREVSPQENGLEEVKPLGEMETD--------LKATGR 1069
T E ++ TE ++L E + ++ + L+E++ E E D ++ATG
Sbjct: 1173 TLEHME-TERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGL 1231
Query: 1070 DSFPRGKTPEVIDAIEEIEIDLEETEREISPQENGLEEVKPLGEMQTDLKATGREISPRE 1129
+ K + ++E + ++E R +S + + + L + T L+ EI
Sbjct: 1232 QTKEELKIAHI--HLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQ---EEIPVLH 1286
Query: 1130 KTPEVIDATEEIDKDLEETGRREISPEENGPEEV--------------KPVDEMETDLKT 1175
+ E++ +E+ + E E+ E++ ++ + E + ++K+
Sbjct: 1287 EEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKS 1346
Query: 1176 TGREGSSREKTREVIDAAEVIETDLEETERE--ISPQENGPEEVKPVGKMETDLKEIREE 1233
+E R+ + + +A EV L+E RE QE+ ++ + + E D E +
Sbjct: 1347 LTKE---RDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKD-NETTKI 1402
Query: 1234 ISQREKVLAEFSAIREKEIDLKETGKR------DIPIMEKVSGKMAVVEEMEADLKETGK 1287
+S+ E+ + SA+ EI++ KR ++ + K + ++E+ + K
Sbjct: 1403 VSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLK 1462
Query: 1288 ENFRERGSEEICVTEE-KVAE--LKQTGKTDISPRENELEETSTSRQTDTHLMQ---SGS 1341
EN +E ++ + EE KVA LK+ +T NEL + ++T+ +Q
Sbjct: 1463 ENIKEIVAKHLETEEELKVAHCCLKEQEET-----INELRVNLSEKETEISTIQKQLEAI 1517
Query: 1342 NDFSAVPSLDIQNISSEVLSMMHTPVEEKRNSEKEVSSHFSHFKISSQTHESDKTEVQGI 1401
ND +I + + V+EK N K+ H + Q+ ES E+
Sbjct: 1518 NDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNR 1577
Query: 1402 QSPDVPEQFSDINLSKSLPQEQKPLEIKPAPFVRSRFKRPKPNLARAALKRETTESEKYI 1461
E I + + + Q+ L+I+ R + K N K + ++ ++Y
Sbjct: 1578 LQESQEEIQIMIKEKEEMKRVQEALQIE-----RDQLKE---NTKEIVAKMKESQEKEYQ 1629
Query: 1462 YEKKS-------------------ETKKMETIVMQENNEQTDTLPSQHDEASLMISREKD 1502
+ K + ET+K+ ++ N + + ++ E +++E+D
Sbjct: 1630 FLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERD 1689
Query: 1503 TLGHRNEEAVILPCTQTERNL--SPSNSCEPKEE---------SQSAPVQKNDSVVSVGT 1551
L EE + + Q + NL + + E +EE + K +VS T
Sbjct: 1690 DL-RSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKT 1748
Query: 1552 NNVNTFQQEMKESVIQTARQ---VRGRLQRPRPNIRKTGQRQIVDKGEAKGIIKEGRTIL 1608
N ++ Q++++ S Q ++ L+ ++++ Q++ +DK +GI+ E
Sbjct: 1749 NEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKE--QQETIDK--LRGIVSE----- 1799
Query: 1609 PKDETEKKVLTVSNSQIETEIEVPSSAVPEHRMY-------ENQSQVVLVENLHVNKTNE 1661
D+ + NS + + ++ EH++ E Q +V +E L ++
Sbjct: 1800 KTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQ 1859
Query: 1662 TIRHENKPYVP-SSAQMTRRKFQKAKPNLGRAHSKKEEPVLEKVTTDQSKEG----KPED 1716
++ + AQ ++ K + + + K+ DQ KE K D
Sbjct: 1860 SLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARD 1919
Query: 1717 HLLQKGASNTQLLLKEKAELLTSLEVSARKDCVGSKESALAKIDAELEE 1765
+Q+ ++L KE E + L ++ + K ++ I +L++
Sbjct: 1920 LEIQQELKTARMLSKEHKETVDKL-----REKISEKTIQISDIQKDLDK 1963
Score = 55.8 bits (133), Expect = 5e-07
Identities = 267/1480 (18%), Positives = 570/1480 (38%), Gaps = 288/1480 (19%)
Query: 336 EIKNKFKREEKTNGWRIDKAFQEKRPFDFDFFAHLLQKVLAEEEKRKQ----KSVKNHSL 391
EIK+ K E+ N I +A + K + L K+ + K++Q K N +
Sbjct: 1343 EIKSLTK--ERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETT 1400
Query: 392 K---EKKSTKPRKNVKVK-KVACEGVNNDPDES---MSSRISDTERSQKDAQTVEEESLT 444
K E + KP+ + ++ ++ G++ ES M S + + Q+ + ++ ES
Sbjct: 1401 KIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQ 1460
Query: 445 LSREDAEQVALEVDLNQKKR-----RRKKQDGANELGVNNLLENATVQAGPSKGEKHKNK 499
L E VA ++ ++ + +++++ NEL VN + + + E +K
Sbjct: 1461 LKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDK 1520
Query: 500 CQAIRPELKEGECSKEQMLSCTQNIDGIVGFASTEKVEKRTDPILSLSNQQDATSVATES 559
Q E+ E KE+ + Q +V+++ + + + A A +S
Sbjct: 1521 LQNKIQEIYE----KEEQFNIKQ----------ISEVQEKVNELKQFKEHRKAKDSALQS 1566
Query: 560 SESSTSDLPS--------FEVGIRALCEVNNAEGSCIEERNVDLKNNSLEIDQTENVKPM 611
ES +L + ++ I+ E+ + + ER+ LK N+ EI
Sbjct: 1567 IESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERD-QLKENTKEIVAKMKESQE 1625
Query: 612 LRGRFQRPKPNLSRAGKKSVLSQGKTESESKNSHSKTSVEKNHVEKDKM--NTLDILRME 669
+F + K + K + E++ + + ++E ++ ++ L+ +R
Sbjct: 1626 KEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLE-NIETENIRLTQILHENLEEMRSV 1684
Query: 670 TTERENPEAETVSVLGEKNCLQEGSQLKALRPVQVRGRLQ----KPKPNAGKAAERKEIL 725
T ER++ + ++ E++ L+E + R ++ + L+ K + + + I+
Sbjct: 1685 TKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIV 1744
Query: 726 ISQEEIGANVEKN---ENESCADRDTP-------QHMEDQSRKDFEEEDVILQPEKNDSF 775
+ +N++K+ N++ +D HM + +++ ++ + EK D
Sbjct: 1745 SEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKL 1804
Query: 776 QNVQPDEPKVLNECLSVQENNKANKLNQVPILRTRFQKPKPNIGRGTGRREISSKEEVLE 835
N+Q D + N +QE + K N+ ++ + + ++++S E+ L+
Sbjct: 1805 SNMQKD---LENSNAKLQEKIQELKANEHQLITLKKDVNET-------QKKVSEMEQ-LK 1853
Query: 836 KILVSGEMAAALRETVRLDTSPKEMVPAEINTKEMQSDLKETGRRAISPREKILDVIDDT 895
K + + + E L+ + K N +EM+S +KE L +++T
Sbjct: 1854 KQIKDQSLTLSKLEIENLNLAQK----LHENLEEMKSVMKERDN---------LRRVEET 1900
Query: 896 IEMETGLKAMGREICLREKTPEVIDATEEIDKDLEEAGRREISPQKNGPEEVKPLGEVET 955
+++E R++ E + T+ D ++++ + K E V L E +
Sbjct: 1901 LKLE------------RDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKIS 1948
Query: 956 DLKATGNESSPREKTPEVTDATEEIDKNLEETGRRKISPRENGPEEVKPVDEMETDLNAT 1015
EKT +++D +++DK+ +E ++KI + ++ V E D+N +
Sbjct: 1949 ------------EKTIQISDIQKDLDKSKDEL-QKKIQELQKKELQLLRVKE---DVNMS 1992
Query: 1016 GRESSPREKTPEVIDATEEIDLEETEREVSPQENGLEEVKPLGEMETDLKATGRDSFPRG 1075
++ + ++E+ +++ Q ++ V+ D+F
Sbjct: 1993 HKKIN---------------EMEQLKKQFEAQNLSMQSVR-------------MDNFQ-- 2022
Query: 1076 KTPEVIDAIEEIEIDLEETEREISPQENGLEEVKPLGEMQTD-LKATGREISPREKTPEV 1134
T ++ +++EEI I ++ + + L +K +M+ D AT RE+ R++
Sbjct: 2023 LTKKLHESLEEIRI--------VAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQ 2074
Query: 1135 IDATEEIDKDLEETGRREISPEENGPEEVKPVDEMETDLKTTGREGSSREKTREVIDAAE 1194
+ + +K L G++ ++ E+ E+ + E+ ++ E+ D E
Sbjct: 2075 V----KPEKRLLSDGQQHLT--ESLREKCSRIKEL-------------LKRYSEMDDHYE 2115
Query: 1195 VIETDLEETEREISPQENGPEEVKPVGKMETDLKEIREEISQREKVLAEFSAIREKEID- 1253
+ + E+EI E ++E+S R K ++ K I+
Sbjct: 2116 CLNRLSLDLEKEI---------------------EFQKELSMRVKANLSLPYLQTKHIEK 2154
Query: 1254 LKETGKRDIPIMEKVSGKMAVVEEMEADLKETGKENFRERGSEEICVTEE------KVAE 1307
L +R ++ K+ V +KE E+ + + I E+ K+
Sbjct: 2155 LFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQH 2214
Query: 1308 LKQTGKTDISPRENELEETSTSRQTDTHLMQSGSNDFSAVPSLDIQNISSEVLSMMHTPV 1367
L+Q D EL + ++ D H+ + DFS + +I +E ++
Sbjct: 2215 LQQ----DCDVPSRELRDLKLNQNMDLHI-EEILKDFS---ESEFPSIKTEFQQVLSNRK 2266
Query: 1368 EEKRNSEKEVSSHFSHFKISS----------QTHESDKTEVQGIQSPDVPEQFSDINLSK 1417
E + E+ +++ F K+ + Q + + I + + +SK
Sbjct: 2267 EMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISK 2326
Query: 1418 SLPQEQKPLEIKPAPFVRSRFKRPKPNLARAALKRETT---------------------E 1456
Q+ K L+ K ++ ++ K +LA A TT E
Sbjct: 2327 EWEQDLKSLKEKNEKLFKN-YQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRE 2385
Query: 1457 SEKYIYEKKSET--KKMETIVMQENNEQTDTLPS-------------QHDEASLMISREK 1501
E ++E K K+ + I MQ+ E T+ + + + + ++ + ++K
Sbjct: 2386 LENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDK 2445
Query: 1502 DTLGHR--NEEAVILPCTQTERNLSPSNSCEPKEESQS---APVQKNDSVVSVGTNNVNT 1556
LG + EE L + +L + + E+ S A V+ V+ + N+
Sbjct: 2446 VALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRR 2505
Query: 1557 FQQEMKESVIQTARQVRGRLQRPRPNIRKTGQRQIVDKGEAKGIIKEGRTILPKDETEKK 1616
QQ SVI P+P+ + + G GI++ + ++ K E
Sbjct: 2506 SQQAQDTSVISEHTD-------PQPS------NKPLTCGGGSGIVQNTKALILKSE---- 2548
Query: 1617 VLTVSNSQIETEIEVPSSAVPEHRMYENQSQVVLVENLHVNKTNETIRHENKPYVPSSAQ 1676
+ ++E EI S ++ Q +L N H++ +T + E + Q
Sbjct: 2549 -----HIRLEKEI---SKLKQQNEQLIKQKNELLSNNQHLSNEVKTWK-ERTLKREAHKQ 2599
Query: 1677 MTRRKFQKAKPNLGRAHSKKEEPVLEKVTTDQSKEGKPED 1716
+T K+ G A KK+ +T Q KE +D
Sbjct: 2600 VTCENSPKSPKVTGTASKKKQ------ITPSQCKERNLQD 2633
Score = 44.3 bits (103), Expect = 0.002
Identities = 293/1470 (19%), Positives = 563/1470 (38%), Gaps = 259/1470 (17%)
Query: 44 ASKPAEPTDVPTVDFGGAEPQEKAPRSSTEKTGGDNDVEESSRSSSTVSQRRKRISSTSS 103
+ K A+ + ++ + QE+ P E+ N V+E S + T+++ + + S
Sbjct: 1259 SEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPN-VKEVSETQETMNELE--LLTEQS 1315
Query: 104 LVKSSVS---VPSESHPLSTINQEAPQPTATSTKEKQPCSDRYRIY--KAQKLREMLKEE 158
K S + + E L+ QE+ + + TKE+ K +L+E ++E
Sbjct: 1316 TTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRET 1375
Query: 159 LRK-EKKQWKNKYAINESQRPPDRSKMTMRDFIYYLPDNNPMTSSLEQEKKTEKPSTPVQ 217
L K ++ Q K + ++N ++ + +K+ + + + P ++ + L E + S +Q
Sbjct: 1376 LAKIQESQSKQEQSLNMKEKDNETTKI-VSEMEQFKPKDSAL---LRIEIEMLGLSKRLQ 1431
Query: 218 TREQEGKSTPNAEDN------EMEEETDDGPLLVPRVKVAEDGSIILDEESLTVEVLRTK 271
E KS +D+ ++ E+D ++ E+ I+ + T E L+
Sbjct: 1432 ESHDEMKSVAKEKDDLQRLQEVLQSESD---------QLKENIKEIVAKHLETEEELKVA 1482
Query: 272 GPCVVEENDPIFE-----RGSTTTYSSFRKNYYS---------KPWSNKETDMFFLAISM 317
C+ E+ + I E T S+ +K + + KE IS
Sbjct: 1483 HCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISE 1542
Query: 318 VGTDFSMIGQLFPHRAR------------IEIKNKFKR---------EEKTNGWRIDKAF 356
V + + Q HR +E+ N+ + +EK R+ +A
Sbjct: 1543 VQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEAL 1602
Query: 357 QEKRPFDFDFFAHLLQKVLAEEEKRKQ------------KSVKNHSLKEKKSTKPR--KN 402
Q +R + ++ K+ +EK Q K + LKE+ T+ +N
Sbjct: 1603 QIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLEN 1662
Query: 403 VKVKKVACEGVNNDPDESMSS--RISDTERSQKDAQTVEEESL------TLSREDAEQVA 454
++ + + + ++ E M S + D RS ++ VE + L T++R+ +Q
Sbjct: 1663 IETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEE 1722
Query: 455 LEVDLNQKKRRRKKQDGANELGVNNLLENATVQAGPSKGEKHKN---KCQ--AIRPELKE 509
L++ K ++ D + E + +Q K +H N K Q I+ EL+
Sbjct: 1723 LKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQ----KDLEHSNDALKAQDLKIQEELRI 1778
Query: 510 GECSKEQMLSCTQNIDGIVGFASTEKVEKRTDPILSLSNQQDATSVATESSESSTSDLPS 569
++ + GIV +EK +K LSN Q + + +L +
Sbjct: 1779 AHMHLKEQQETIDKLRGIV----SEKTDK-------LSNMQKDLENSNAKLQEKIQELKA 1827
Query: 570 FEVGIRALC-EVNNAEG--SCIEERNVDLKNNSLEIDQTE----NVKPMLRGRFQRPKPN 622
E + L +VN + S +E+ +K+ SL + + E N+ L + K
Sbjct: 1828 NEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSV 1887
Query: 623 LS-RAGKKSVLSQGKTESES-KNSHSKTSVEKNHVEKDKMNTLDILRMETTERENPEAET 680
+ R + V K E + K S +T ++++ L RM + E + ET
Sbjct: 1888 MKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQE----LKTARMLSKEHK----ET 1939
Query: 681 VSVLGEKNCLQEGSQLKALRPVQVRGRLQKPKPNAGKAAE---RKEILISQEEIGANVE- 736
V L EK + E K ++ ++ L K K K + +KE+ + + + N+
Sbjct: 1940 VDKLREK--ISE----KTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSH 1993
Query: 737 KNENESCADRDTPQHMEDQSRKDFEEEDVILQPEKNDSFQNVQPDEPKVLNECLSVQENN 796
K NE +Q +K FE +++ +Q + D+FQ K L+E
Sbjct: 1994 KKINEM-----------EQLKKQFEAQNLSMQSVRMDNFQLT-----KKLHE-------- 2029
Query: 797 KANKLNQVPILRTRFQKPKPNIGRGTGRREISSKEEVLEKILVSGEMAAALRETVRLDTS 856
L ++ I+ R E+ +E L+ + + A LRE + D
Sbjct: 2030 ---SLEEIRIVAKE-------------RDELRRIKESLK--MERDQFIATLREMIARDRQ 2071
Query: 857 PKEMVPAEINTKEMQSDLKETGRRAISPREKILDVIDDTIEMETGLKAMGREICLREKTP 916
++ P + + Q L E+ R S +I +++ EM+ + + R
Sbjct: 2072 NHQVKPEKRLLSDGQQHLTESLREKCS---RIKELLKRYSEMDDHYECLNR--------- 2119
Query: 917 EVIDATEEIDKDLEEAGRREISPQKNGPEEVKPLGEVETDLKATGNESSPREKTPEVTDA 976
+ DLE +EI QK E ++ N S P +T +
Sbjct: 2120 --------LSLDLE----KEIEFQK------------ELSMRVKANLSLPYLQTKHI--- 2152
Query: 977 TEEIDKNLEETGRRKISPRENGPEEVKPVDEMETDLNATGRESSPREKTPEVIDATEE-- 1034
+ L +R +++K V T + ES + + + ID E+
Sbjct: 2153 -----EKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEM-DFIDEVEKQK 2206
Query: 1035 ---IDLEETEREVSPQENGLEEVKPLGEM----ETDLKATGRDSFPRGKT--PEVIDAIE 1085
I ++ +++ L ++K M E LK FP KT +V+ +
Sbjct: 2207 ELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRK 2266
Query: 1086 EIEIDLEE---TEREISPQENGLEEVKPLGEMQTDLKATGREISPREKTPEVIDATEEID 1142
E+ LEE T +I +NG+++ Q + R I+ ++ E + + I
Sbjct: 2267 EMTQFLEEWLNTRFDIEKLKNGIQKEND-RICQVNNFFNNRIIAIMNESTEFEERSATIS 2325
Query: 1143 KDLEETGRREISPEENGPEEVKPVDEMETDLKTTGREGSSREKTREVIDAAEVIETDLEE 1202
K+ E+ + S +E + K ++T L + G+ T + V +
Sbjct: 2326 KEWEQDLK---SLKEKNEKLFKNYQTLKTSLAS----GAQVNPTTQDNKNPHVTSRATQL 2378
Query: 1203 TEREISPQENGPEEVKPVG-KMETDLKEIREEISQREKVLAEFSA-IREKEIDLKETGKR 1260
T +I EN E K E+ + ++++E+ ++A+ A + E L++T +
Sbjct: 2379 TTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKET 2438
Query: 1261 DIPIMEKVS-GKMAVVEEMEADLK------ETGKENFRERGSEEICVTEEKVAELKQTGK 1313
+ +KV+ G EE+E DLK + K + +EI T+ V K+ +
Sbjct: 2439 IQVLQDKVALGAKPYKEEIE-DLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIR 2497
Query: 1314 --TDISPRENELEETST-SRQTDTHLMQSGSNDFSAVPSLDIQNISSEVLSMMHTPVEEK 1370
+ R + ++TS S TD S S +QN + +L H +E++
Sbjct: 2498 LLRENLRRSQQAQDTSVISEHTDP--QPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKE 2555
Query: 1371 RNSEKEVSSHFSHFK---ISSQTHESDKTE 1397
+ K+ + K +S+ H S++ +
Sbjct: 2556 ISKLKQQNEQLIKQKNELLSNNQHLSNEVK 2585
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 95.1 bits (235), Expect = 8e-19
Identities = 343/1738 (19%), Positives = 692/1738 (39%), Gaps = 303/1738 (17%)
Query: 382 KQKSVKNHSLKEKKSTKPRKNVKVKKVACEGVNNDPDESMSSRISDTERSQKDAQTVEEE 441
KQ + + L+E+K R + + A + + E+ + +T EEE
Sbjct: 392 KQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEE 451
Query: 442 SLTLSRE---------------DAEQVALEVDLNQKKRRRKKQDGANELGV--NNLLENA 484
++L +E EQ+A L++K+ RK+Q+ +L E
Sbjct: 452 RISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQM 511
Query: 485 TVQAGPSKGEKHK---NKCQAIRPELKEGECSKEQMLSCTQN-IDGIVGFASTEKVEKRT 540
V S+ E K K Q L+E E K+ +L+ ++N + + A T +
Sbjct: 512 KVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTR--- 568
Query: 541 DPILSLSNQQDATSVATESSESSTSDLPSFEVGIRALCEVNNAEGS-CIEERNVDLKNNS 599
IL L + + + + +++ + DL V + A +N E + +E+ +L++
Sbjct: 569 --ILEL---ESSLEKSLQENKNQSKDL---AVHLEAEKNKHNKEITVMVEKHKTELESLK 620
Query: 600 LEIDQ--TENVKPMLRGRFQRPKPNLSRAGKKSVLSQGKTESESKN-SHSKTSVEKNHVE 656
+ D TE ++ +L+ ++Q L + K E E + K + + H+E
Sbjct: 621 HQQDALWTEKLQ-VLKQQYQTEMEKL----------REKCEQEKETLLKDKEIIFQAHIE 669
Query: 657 KDKMNTLDILRMETTERENPEAETVSVLGEKNCLQEGSQLKALR------PVQVRGRLQK 710
+ TL+ L ++ TE E+ +E VL ++ L+E +L L+ ++ ++ +
Sbjct: 670 EMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEE--ELSVLKDQTDKMKQELEAKMDE 727
Query: 711 PK----PNAGKAAERKEILISQEEIGANVEKNENESC---ADRDTPQHM-------EDQS 756
K + E+ I + E + N+ E D+ +H D
Sbjct: 728 QKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIK 787
Query: 757 RKDFEEEDVILQPEKNDSFQNVQPDEPKVLNECLSVQENNKANKLNQVPILRTRFQKPKP 816
R + E + + + S+Q+ ++ K E L+ Q K L IL T+
Sbjct: 788 RSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLA-QLQQKLLDLETERILLTK------ 840
Query: 817 NIGRGTGRREISSKEEVLEKILVSGEMAAALRETVRLDTSPKEMVPAEINTKEMQSDLKE 876
+ +++ E KI V M ++ ++ K + T+ +S L++
Sbjct: 841 QVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSL------TQVYESKLED 894
Query: 877 TGRRAISPREKILDVIDDTIEMETGLKAMGREI-CLREKTPEVIDATEEIDKDLEEAGRR 935
+ ++ +++ + ++M G K +EI L +K D+ ++++ E +
Sbjct: 895 GNKEQEQTKQILVEKENMILQMREGQK---KEIEILTQKLSAKEDSIHILNEEYETKFKN 951
Query: 936 EISPQKNGPEEVKPLGE------------VETDLKATGNESSPREK-------------T 970
+ + ++ K + E ++ +L+ T E S +EK +
Sbjct: 952 QEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANS 1011
Query: 971 PEVTDATEEIDKN-------LEETGRRKISPRENGPEEVKPVDEMETDLNATGRESSPRE 1023
++DA ++ N L E RR+++ + E K +++ +L E +E
Sbjct: 1012 AGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWE--KKLNQQAEELQEI-HEIQLQE 1068
Query: 1024 KTPEVIDATEEI-----DLEETEREVS-PQENGLEEVKPLGEMETDLKATGR--DSFPRG 1075
K EV + ++I + EE +E++ +E G+++ L E++ LK +S +
Sbjct: 1069 KEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQD 1128
Query: 1076 KTPEVIDAIEEIEIDLEETEREISPQENGLEEVKPLGEMQTDLKATGREISPREKTPEVI 1135
+T ++ +E++E+DL ++ +E + + L E+K L E + K E++ + KT
Sbjct: 1129 ET-KLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAE---EDKRKVSELTSKLKT---- 1180
Query: 1136 DATEEIDKDLEETGRREISPEENGPEEVKPVDE---METDLKTTGREGSSREKTREVIDA 1192
T+E + L+ + + E+ E K + E ++ D+ E KT E+I+
Sbjct: 1181 --TDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELIN- 1237
Query: 1193 AEVIETDLEETEREISPQENGPEEVK--------PVGKMETDLKEIREEISQREKVLAEF 1244
+ + IS ++ +VK V ++E L+++ EE + +
Sbjct: 1238 --ISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQA 1295
Query: 1245 S-AIREKEIDLKETGKRDIPIMEKVSGKMAVVEEMEADLKETGKENFRERGSEEICVTEE 1303
+ + EKE +K K DI ++V E EA KE G + + +E C+T+
Sbjct: 1296 THQLEEKENQIKSM-KADIE---------SLVTEKEALQKEGGNQQ-QAASEKESCITQL 1344
Query: 1304 KVAELKQTGKTDISP---RENELEETSTSRQ-TDTHLMQSGSNDFS----AVPSL----- 1350
K + + +E ++E +S S+Q TD ++ S S A+ SL
Sbjct: 1345 KKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYD 1404
Query: 1351 --------DIQNISSEVLSMMHTPVEEKRNSEKEV---SSHFSHFKISSQT----HESDK 1395
+Q++S +V T +EK ++ ++V S+ FS +K +Q+ H++
Sbjct: 1405 EEKCELLDQVQDLSFKV----DTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTV 1460
Query: 1396 TEVQ---GIQSPDVPEQFSDINLSK-SLPQEQKPLEIKPAPFV--RSRFKRPKPNLARAA 1449
E+Q ++S + E+ INL K L Q+ K + +S+ ++ + NL
Sbjct: 1461 KELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNL-ETE 1519
Query: 1450 LKRETT---ESEKYIYEKKSETKKMETIVMQENNEQTDTLPSQHDEASLM------ISRE 1500
LK +T E E +I +K E + + V++ N+Q D +H E + E
Sbjct: 1520 LKSQTARIMELEDHITQKTIEIESLNE-VLKNYNQQKDI---EHKELVQKLQHFQELGEE 1575
Query: 1501 KDTLGHRNEEAVILPCTQT----------ERNLSPSN-SCEPKEESQSAPVQKNDSVVSV 1549
KD EE ++ Q ++ L N S + KEE A D + S
Sbjct: 1576 KDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKA---LEDRLESE 1632
Query: 1550 GTNNVNTFQQEMKESVIQTARQVRGRLQRPRPNIRKTGQ-------RQIVDKGEAKGIIK 1602
+ +++ ++ + +Q+ +++ +K + ++ ++ I++
Sbjct: 1633 SAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILE 1692
Query: 1603 EGRTILPKDETEKKVL--TVSNSQIETEIEVPSSAVPEHRMYENQSQVVLVENLHVNKTN 1660
E + ++E ++ + N TE E S + YE + V+ K
Sbjct: 1693 EKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLL 1752
Query: 1661 ETIRHENKPYVPSSAQMTRRKFQKAKPNLGRAHSKKEEPVLEKVTTDQSKEGKPEDHLLQ 1720
+ + E + V S +M R ++Q+ L A +K+ E DQS G ++ L +
Sbjct: 1753 QRVGQEKEETVSSHFEM-RCQYQERLIKLEHAEAKQHE--------DQSMIGHLQEELEE 1803
Query: 1721 KGASNTQLLLKEKAELLTSLEVSARKDCVGSKESALAKIDAE--LEEVGPSRRVGEETVG 1778
K SL V+ + G K + AK + E ++V ++T+
Sbjct: 1804 KNKK-------------YSLIVAQHVEKEGGKNNIQAKQNLENVFDDV-------QKTLQ 1843
Query: 1779 DNSPSSVVEEQYLNKLTSCPQPLNE----------TSYSKI----ALDGKTTISSTSEYE 1824
+ + + EQ + +L SC E + Y K+ +DG+ T E
Sbjct: 1844 EKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRN--KPTELLE 1901
Query: 1825 RNRGERRSHKKFKPNVTRG------------RGSKRVRGKTSKKEPRASKAMLVTLRASQ 1872
N E+ +P + G++R + K K+ R K + + + Q
Sbjct: 1902 ENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQ 1961
Query: 1873 EEDDDADDFESDYEEESYHLAPEEVNKAPVFVPVGLRS-PEPVSAQIEETMEELEITV 1929
+E + + +Y++E +E + L+ + Q+ + +ELE+T+
Sbjct: 1962 QE---LEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTI 2016
Score = 87.8 bits (216), Expect = 1e-16
Identities = 307/1729 (17%), Positives = 661/1729 (38%), Gaps = 202/1729 (11%)
Query: 62 EPQ-EKAPRSSTEKTGGDNDVEE--SSRSSSTVSQRRKRISSTSSLVKSSVSVPSESHPL 118
EPQ E + ++ G+ VE+ S ++ T+ QR KR + K ++ E L
Sbjct: 252 EPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTL 311
Query: 119 STINQEAPQPTATST-KEKQPCSDRYRIYKAQKLREMLKEELRKEKKQWKNKYAINESQR 177
T +EA Q +E + D + K + + ++ + E+ + I E++R
Sbjct: 312 LTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKR 371
Query: 178 PPDRSKMTMRDFIYYLPDNNPMTSSLEQEKKTEKPSTPVQTREQEGKSTPNAEDNE---- 233
+ + I L ++ +E + +K + E+ K+ A+ E
Sbjct: 372 QMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARR 431
Query: 234 -MEEETDDGPLLVPRVKVAEDGSIILDEE--SLTVEVLRTKGPCVVEENDPIFERGSTTT 290
++ E D+ ++K E S +EE SL E+ R K +E + ++ S
Sbjct: 432 KLKAEMDE------QIKTIEKTS---EEERISLQQELSRVK-----QEVVDVMKKSSEEQ 477
Query: 291 YSSFRKNYYSKPWSNKETDMFFLAISMVGTDFSMIGQLFPHRARIEIKNKFKREEKTNGW 350
+ +K + K + KE ++ + +F ++ +++ E + +E+
Sbjct: 478 IAKLQK-LHEKELARKEQELT-KKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESL 535
Query: 351 RIDKAFQEKRPFDFDFFAHLLQKVLAEEEKRKQKSVKNHSLKEKKSTKPRKNVKVKKVAC 410
+++ +K+ + + L+ + E E + + ++ S EK + + K V
Sbjct: 536 ALEELELQKKAILTES-ENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHL 594
Query: 411 EGVNNDPDESMSSRISDTERSQKDAQTVEEESLTLSREDAEQVALEVDLNQKKRRRK-KQ 469
E N ++ ++ + E+ + + ++++ + L E + + + +K R K +Q
Sbjct: 595 EAEKNKHNKEITVMV---EKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQ 651
Query: 470 DGANELGVNNLLENATVQAGPSKGEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGIVG 529
+ L ++ A ++ EK K + EL+ ++L ++ +
Sbjct: 652 EKETLLKDKEIIFQAHIE---EMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELS 708
Query: 530 FASTEKVEKRTDPILSLSNQQDATSVATESSESSTSDLPSFEVGI----RALCEVNNAEG 585
+ + + + + Q++ + S + EV I +AL + N
Sbjct: 709 VLKDQTDKMKQELEAKMDEQKN------HHQQQVDSIIKEHEVSIQRTEKALKDQINQLE 762
Query: 586 SCIEERNVDLKNNSLEIDQTENVKPMLRGRFQRPKPNLSRAGKKSVLSQGKTESESKNSH 645
++ER+ LK + ++ E +R + L +A K + Q S +H
Sbjct: 763 LLLKERDKHLKEHQAHVENLE-------ADIKRSEGELQQASAKLDVFQ----SYQSATH 811
Query: 646 SKTSVEKNHVEKDKMNTLDILRMETTERENPEAETVSVLGEKNCLQEGSQLKALRPVQVR 705
+T + + + + LD+ TER + V +K + ++ +
Sbjct: 812 EQTKAYEEQLAQLQQKLLDL----ETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLM 867
Query: 706 GRLQKPKPNAG-KAAERKEILISQEEIGANVEKNENESCADRDTP-QHMEDQSRKDFE-- 761
+L+K K ++ S+ E G ++ + +++ M + +K+ E
Sbjct: 868 QQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEIL 927
Query: 762 -------EEDV-ILQPEKNDSFQNVQPDEPKVLNECLSVQENNKANKLNQVPILRTRFQK 813
E+ + IL E F+N + KV + +QE K L+Q + +K
Sbjct: 928 TQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQ----EAKLKK 983
Query: 814 PKPNIGRGTGRREISSKEEVLEKILVSGEMAAALRETVRLDTSPKEMVPA--EINTKEMQ 871
N ++E ++LE + A RL+T+ KE + + E++ +E+
Sbjct: 984 ELENTALELSQKEKQFNAKMLE--MAQANSAGISDAVSRLETNQKEQIESLTEVHRRELN 1041
Query: 872 SDLKETGRRAISPREKILDVIDDTIEMETGLKAMGREICLREKTPEVIDATEEI---DKD 928
+ ++ E++ ++ EI L+EK EV + ++I +
Sbjct: 1042 DVISIWEKKLNQQAEELQEI---------------HEIQLQEKEQEVAELKQKILLFGCE 1086
Query: 929 LEEAGRREISPQKNGPEEVKPLGEVETDLKA-TGNESSPREKTPEVTDATEEIDKNLEET 987
EE + ++ G ++ L E++ LK + + +S + ++ E+++ +L ++
Sbjct: 1087 KEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKS 1146
Query: 988 GRRKISPREN-------GPEEVKPVDEMETDLNATGRE----SSPREKTPEVIDATEEID 1036
+ +E E+ + V E+ + L T E S EK+ + ++ + ++
Sbjct: 1147 LKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLE-DKSLE 1205
Query: 1037 LEETEREVSPQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEVIDAIEEIEIDLEETER 1096
++ E++ Q L+ E + K + KT ++ I + R
Sbjct: 1206 FKKLSEELAIQ---LDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQ------HR 1256
Query: 1097 EISPQENGLEEVKPLGEMQTDLKATGREISPREKTPEVIDATEEIDKDLEETGRREISPE 1156
+E L + + E++ L R+++ + T + + ++ LEE +
Sbjct: 1257 TTKVKEALLIKTCTVSELEAQL----RQLTEEQNTLNI--SFQQATHQLEE--------K 1302
Query: 1157 ENGPEEVKP-VDEMETDLKTTGREGSSREKTREVIDAAEVIETDLEETEREISPQENGPE 1215
EN + +K ++ + T+ + +EG ++++ AA E+ + + ++E+S E
Sbjct: 1303 ENQIKSMKADIESLVTEKEALQKEGGNQQQ------AASEKESCITQLKKELS------E 1350
Query: 1216 EVKPVGKMETDLKEIREEISQREKVLAEFSAIREKEIDLKETGKRDIPIMEKVSGKMAVV 1275
+ V M+ +LKE + EIS K L + + + I L E + ++ + +
Sbjct: 1351 NINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCEL 1410
Query: 1276 EEMEADLKETGKENFRERGS--EEICVTEEKVAELKQTGKTDISPRENELEETSTSRQTD 1333
+ DL +E+ S E++ K +E K+ ++ + +N ++E +
Sbjct: 1411 LDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELK 1470
Query: 1334 THLMQSGSNDFSAV-PSLDIQN-----ISSEVLSMMHTPVEEKRNSEKEVSSHFSHFKIS 1387
+ + + LD QN + E+ +++ N E E+ S + +
Sbjct: 1471 SKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARI-ME 1529
Query: 1388 SQTHESDKTEVQGIQSPDVPEQFSDINLSKSLPQEQKPLEIKPAPFVRSRFKRPKPNLAR 1447
+ H + KT I+ + E + N K + E K L K F K N +
Sbjct: 1530 LEDHITQKT----IEIESLNEVLKNYNQQKDI--EHKELVQKLQHF--QELGEEKDNRVK 1581
Query: 1448 AALKR-ETTESEKYIYEKKSETKKME----TIVMQENNEQTDTLPSQHDEASLMISREKD 1502
A ++ T E++ Y + + ETKK E + ++ E+ L + + S E
Sbjct: 1582 EAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELK 1641
Query: 1503 TLGHRNEEAV--ILPCTQTERNLSPSNSCEPKEESQSAPVQKNDSVVSVGTNNVNTFQQE 1560
+ A+ L E+ E + +Q+ + V + + + +
Sbjct: 1642 RKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESS 1701
Query: 1561 MKESVIQTARQVRGRLQRPRPNIRK-TGQRQIVDKGEAKGIIKEGRTILPKDETEKKVLT 1619
E++I + R N+ T Q + +G + +E ++L ++ TEK+ L
Sbjct: 1702 QSETLI---------VPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLL 1752
Query: 1620 VSNSQIETEIEVPSSAVPEHRMYENQSQVVLVENLH-----------VNKTNETIRHENK 1668
Q + E V H Q Q L++ H + E + +NK
Sbjct: 1753 QRVGQEKEE------TVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNK 1806
Query: 1669 PYVPSSAQMTRRKFQK----AKPNLGRAHSKKEEPVLEKVTTDQSKEGK 1713
Y AQ ++ K AK NL ++ + EK T Q E K
Sbjct: 1807 KYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQK 1855
Score = 75.1 bits (183), Expect = 9e-13
Identities = 235/1278 (18%), Positives = 487/1278 (38%), Gaps = 159/1278 (12%)
Query: 331 HRARIEIKNKFKREEKTNGWRIDKAFQEKRPFDFDFFAHLLQKVLAEEEKRKQKSVKNHS 390
H E + KFK +EK +++K Q+ + L+K L ++E + +K ++N +
Sbjct: 939 HILNEEYETKFKNQEK----KMEKVKQKAKEMQ-----ETLKKKLLDQEAKLKKELENTA 989
Query: 391 LK--EKKSTKPRKNVKVKKVACEGVNN-------DPDESMSSRISDTERSQKDAQTVEEE 441
L+ +K+ K +++ + G+++ + E + S R D ++ E+
Sbjct: 990 LELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEK 1049
Query: 442 SLTLSREDAEQVALEVDLNQKKRR-RKKQDGANELGVNNLLENATVQAGPSKGEKHKNKC 500
L E+ +++ E+ L +K++ + + G N + +G K
Sbjct: 1050 KLNQQAEELQEIH-EIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTL 1108
Query: 501 QAIRPELKEGECSKEQMLSCTQNIDGIVGFASTEKVEKRTDPILS----LSNQQDATSVA 556
++ +LK+ + + A EK+E + L L Q +
Sbjct: 1109 NELQEQLKQKSAHVNSLAQDETKLK-----AHLEKLEVDLNKSLKENTFLQEQLVELKML 1163
Query: 557 TESSESSTSDLPSFEVGIRALCEVNNAEGSCIEERNVDLKNNSLEIDQTENVKPMLRGRF 616
E + S+L S ++ E + S E+ N L++ SLE + +
Sbjct: 1164 AEEDKRKVSELTS---KLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAI----- 1215
Query: 617 QRPKPNLSRAGKKS-VLSQGKTESESKNSHSKTSV---EKNHVEKDKMNTLDILRMETTE 672
L KK+ L + KT S SKT+ +H + + L ++T
Sbjct: 1216 -----QLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCT 1270
Query: 673 RENPEAETVSVLGEKNCLQEGSQLKALRPVQVRGRLQKPKPNAGKAAERKEILISQEEIG 732
EA+ + E+N L Q + + +++ K + KE L ++ G
Sbjct: 1271 VSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEAL---QKEG 1327
Query: 733 ANVEK--NENESCADRDTPQHMEDQSRKDFEEEDVILQPEKNDSFQNVQPDEPKVLNECL 790
N ++ +E ESC + + E+ + +E++ + + S D L +
Sbjct: 1328 GNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSI 1387
Query: 791 SVQENNKANKLNQVPILRTRFQKPKPNIGRGTGRREISSKEEVLEKILVSGEMAAALRET 850
S+ E A + LR ++ + K E+L+++ +
Sbjct: 1388 SLSEKEAA-----ISSLRKQYDEEKC---------------ELLDQVQDL---------S 1418
Query: 851 VRLDTSPKEMVPAEINTKEMQSDLKETGRRAISPREKILDVIDDTIEMETGLKAMGREIC 910
++DT KE + A + + E ++A S + + + E++ L+ +E
Sbjct: 1419 FKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVK---ELQIQLELKSKEAY 1475
Query: 911 LREKTPEVIDATEEIDKDLE--EAGRREISPQKNGPEEVKPLGEVETDLKA-TGNESSPR 967
EK ++ EE+D+ + + + E+ K+ E K +ET+LK+ T
Sbjct: 1476 --EKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKME--KKESNLETELKSQTARIMELE 1531
Query: 968 EKTPEVTDATEEIDKNLEETGRRKISPRENGPEEVKPVDEMETDLNATGRESSPREKTPE 1027
+ + T E +++ L+ ++K + ++++ E+ G E R K E
Sbjct: 1532 DHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQEL-------GEEKDNRVKEAE 1584
Query: 1028 VIDATEEIDLEETEREVSPQENGLEEVK-PLGEMETDLKATGRDSFPRGKTPEVIDAIEE 1086
T E + + E+ ++ LE V + E +LKA D ++ + +
Sbjct: 1585 EKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKAL-EDRLESESAAKLAELKRK 1643
Query: 1087 IEIDLEETEREISPQENGLEEV------KPLGEMQTDLKATGREISPREKTPEVIDATEE 1140
E + ++++ Q EE L E+ T L+ RE+ E+ + +++++
Sbjct: 1644 AEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQS 1703
Query: 1141 IDKDLEETGRR--EISPEENGPEEVKPVDEMETDLKTTGREGSSREKTREVIDAAEVIET 1198
+ + + + +E + E + R + +EK + + E ET
Sbjct: 1704 ETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRV-GQEKEET 1762
Query: 1199 DLEETEREISPQENGPEEVKPVGKMETD---LKEIREEISQREKVLAEFSAIREKEIDLK 1255
E QE + K D + ++EE+ ++ K ++S I + ++ K
Sbjct: 1763 VSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNK---KYSLIVAQHVE-K 1818
Query: 1256 ETGKRDIP-----------IMEKVSGKMAVVEEMEADLKETGKENFRERGSEEICVTE-- 1302
E GK +I + + + K + +E +KE R++ + + E
Sbjct: 1819 EGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELT 1878
Query: 1303 EKVAELKQTGKTDISPRENELEETSTSRQTDTHLMQSG--SNDFSAVPSLDIQNISSEVL 1360
K +L+ + D + EL E +T ++ +HL+Q SN + L+ + +E
Sbjct: 1879 SKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAE-- 1936
Query: 1361 SMMHTPVEEKRNSEKEVSSHFSHFKISSQTHESDKTEVQGIQSPDVPEQFSDINLSKSLP 1420
EK+ KE+ ++ + H+ Q ++ ++ D + +
Sbjct: 1937 -------REKQKLGKEIVRLQKDLRMLRKEHQ---------QELEILKKEYDQEREEKIK 1980
Query: 1421 QEQKPLEIKPAPFVRSRFKRPKPNLARAALKRETTESEKYIYEKKSETKKMETIVMQENN 1480
QEQ+ LE+K ++ + LA+ + E T E ++ E + +E+ +E N
Sbjct: 1981 QEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLES-HQEETN 2039
Query: 1481 EQTDTLPSQHDEASLMISREKDTLGHRNEEAVILPCTQTERNLSPSNSCEPKEESQSAPV 1540
+ + + D+ R ++ L R EE T R+L EE Q
Sbjct: 2040 QLLKKIAEKDDDLKRTAKRYEEILDAREEE-----MTAKVRDLQTQ-----LEELQKKYQ 2089
Query: 1541 QKNDSVVSVGTNNVNTFQ 1558
QK + + G +NV +
Sbjct: 2090 QKLEQEENPGNDNVTIME 2107
Score = 70.9 bits (172), Expect = 2e-11
Identities = 266/1419 (18%), Positives = 532/1419 (37%), Gaps = 208/1419 (14%)
Query: 807 LRTRFQKPKPNIGRGTGRREISSKEEVLEKIL-----VSGEMAAALRETVRLDTSPKEMV 861
+R+R + GT RE + +K+ V + ++E++ +S + +V
Sbjct: 35 MRSRTSSFTEQLDEGTPNRESGDTQSFAQKLQLRVPSVESLFRSPIKESLFRSSSKESLV 94
Query: 862 PAEINTKEMQSDLKETGRRAISPREKILDVID-----DTIEMET---GLKAMGREIC-LR 912
+ DL + P + + D D++ E L+ M R + R
Sbjct: 95 RTSSRESLNRLDLDSSTASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYR 154
Query: 913 EKTPEVIDATEEIDKDLEEAGRREISPQKNGPEEVKPLGEVETDLKATGNESSPREKTPE 972
K E++ A + + ++ ++ + I Q + ++ + E+ +L+ ++ + + E
Sbjct: 155 GKYSELVTAYQMLQREKKKL--QGILSQSQD-KSLRRIAELREELQM--DQQAKKHLQEE 209
Query: 973 VTDATEEIDKNLE--ETGRRKISPR-ENGPEEV---KPVDEMETDLNATGRESSPR-EKT 1025
+ EE D+ + +T + R NGP V KP+ ++E +E +P +
Sbjct: 210 FDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGE 269
Query: 1026 PEVIDATEEIDLEETEREVSPQENGLEEVKPL--GEMETDLKATGRDSFPRGKTPEVIDA 1083
P V D T LE ++ V QEN L+ K E T + + E +
Sbjct: 270 PVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQE 329
Query: 1084 IEEIEIDLEETER--------------EISPQENGLEEVKPLGEMQTDLKATGREISP-R 1128
+E+I+ DL E+ E Q+ G+ + +M L+ EI+ R
Sbjct: 330 LEKIK-DLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLR 388
Query: 1129 EKTPEVIDATEEIDKDLEETGRREISPEENGPEEVKPVDEMETDLKTTGREGSSREKTRE 1188
+ ++ EE+ + E++ R +E+E L T + +R K +
Sbjct: 389 SRIKQMTTQGEELREQKEKSERAAF-------------EELEKALSTAQKTEEARRKLKA 435
Query: 1189 VIDAAEVIETDLEETEREISPQENGPEEVKPVGKMETDLKEIREEISQREKVLAEFSAIR 1248
+D E I+T +E+T E E + ++ +L +++E+ K +E +
Sbjct: 436 EMD--EQIKT-IEKTSEE--------ERI----SLQQELSRVKQEVVDVMKKSSEEQIAK 480
Query: 1249 EKEIDLKETGKRDIPIMEKVSGKMAVVEEMEADLKETGKENFRERGSEEICVTEEK---- 1304
+++ KE +++ + +K ++ E + +E K + SE + +++EK
Sbjct: 481 LQKLHEKELARKEQELTKK-------LQTREREFQEQMKVALEKSQSEYLKISQEKEQQE 533
Query: 1305 ---VAELKQTGKTDISPRENELEETSTSRQTDTHLMQSGSNDFSAVPSLDIQNISSEVLS 1361
+ EL+ K ++ EN+L + ++ +T+ + + S SL S+ L+
Sbjct: 534 SLALEELELQKKAILTESENKLRD--LQQEAETYRTRILELESSLEKSLQENKNQSKDLA 591
Query: 1362 MMHTPVEEKRNSEKEVSSHFSHFKISSQTHESDKTEVQGIQSPDVPEQFSDINLSKSLPQ 1421
+ + K N E V ++ S H+ D + +Q Q L + Q
Sbjct: 592 VHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQ 651
Query: 1422 EQKP-LEIKPAPFVRSRFKRPKPNLARAALKRETTES---------------EKYIYEKK 1465
E++ L+ K F + + L + +K+ ES E+ + K
Sbjct: 652 EKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLK 711
Query: 1466 SETKKMETIVMQENNEQTDTLPSQHDEASLMISREKDTLGHRNEEAVILPCTQTERNLSP 1525
+T KM+ QE + D + H + I +E + R E+A+ Q E L
Sbjct: 712 DQTDKMK----QELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKE 767
Query: 1526 SN----SCEPKEESQSAPVQKNDSVVSVGTNNVNTFQQEMKESVIQTARQVRGRLQRPRP 1581
+ + E+ A +++++ + + ++ FQ + QT Q +
Sbjct: 768 RDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQK 827
Query: 1582 NIRKTGQRQIVDK--GEAKGIIKEGRTILPKDETE----KKVLTVSNSQIETEI----EV 1631
+ +R ++ K E + K+ T L + + + L NS++E ++ +V
Sbjct: 828 LLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQV 887
Query: 1632 PSSAVPEHRMYENQSQVVLVEN----LHVNK---------TNETIRHENKPYVPSSAQMT 1678
S + + + Q++ +LVE L + + T + E+ ++ + T
Sbjct: 888 YESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYET 947
Query: 1679 RRKFQKAKPNLGRAHSKKEEPVLEKVTTDQSKEGKPE-----DHLLQK------------ 1721
+ K Q+ K + +K+ + L+K DQ + K E L QK
Sbjct: 948 KFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMA 1007
Query: 1722 ---------GASNTQLLLKEKAELLTSLEVSARKDCVGSKESALAKIDAELEEVGPSRRV 1772
S + KE+ E LT + D + E L + EL+E+
Sbjct: 1008 QANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEI------ 1061
Query: 1773 GEETVGDNSPSSVVEEQYLNKLTSCPQPLNETSYSKIALDGKTTISSTSEYERNRGERRS 1832
E V E + L C + + + +G ++ +E + ++ +
Sbjct: 1062 -HEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSA 1120
Query: 1833 H--------KKFKPNVTRGRGSKRVRGKTSKKEPRASKAMLVTLRASQEEDD-DADDFES 1883
H K K ++ + V S KE + LV L+ EED + S
Sbjct: 1121 HVNSLAQDETKLKAHLEK----LEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTS 1176
Query: 1884 -----DYEEESYHLAPEEVNKAPVFVPVGLRSPEPVSAQIEETMEELEITVNVPDVGCIA 1938
D E +S + E+ NK S E S + ++ EEL I +++ C
Sbjct: 1177 KLKTTDEEFQSLKSSHEKSNK----------SLEDKSLEFKKLSEELAIQLDI----CCK 1222
Query: 1939 VVEHELPNTDVTTEEMKQEENLSVPFEMTTSEHIQDEPGTNDGSTEAAITLLTMGDLVLQ 1998
E L + T E+ + ++ H Q T I T+ +L Q
Sbjct: 1223 KTEALL---EAKTNELINISSSKTNAILSRISHCQHR--TTKVKEALLIKTCTVSELEAQ 1277
Query: 1999 -SEISSEQGDVGVCIIPHVHS-KDKSHIPSSLDNVNHKIVHECQELSSPVITTSPASFEE 2056
+++ EQ + + H ++K + S+ +V E + L A+ E+
Sbjct: 1278 LRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEK 1337
Query: 2057 NKIVLE-EQSSREEISLMEKVKENATPTRNTISKVTSNL 2094
+ + ++ E I+ + +KE + IS ++ L
Sbjct: 1338 ESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQL 1376
Score = 64.3 bits (155), Expect = 2e-09
Identities = 238/1328 (17%), Positives = 505/1328 (38%), Gaps = 227/1328 (17%)
Query: 945 EEVKPLGEVETDLKATGNESSPREKTPEVTDATEEIDKNLEETGRRKISPRENGPEEVK- 1003
EE + L + +A+ N S+P + TE++D E T R+ ++ ++++
Sbjct: 11 EEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLD---EGTPNRESGDTQSFAQKLQL 67
Query: 1004 PVDEMETDLNATGRESSPREKTPEVI------DATEEIDLEETEREVSPQENGLEEVKPL 1057
V +E+ + +ES R + E + ++ +DL+ + P + E + L
Sbjct: 68 RVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDMDSEAEDL 127
Query: 1058 ---------GEMETDLKATGRD-SFPRGKTPEVIDAIEEIEIDLEETEREIS-PQENGLE 1106
++ L+ R S RGK E++ A + ++ + ++ + +S Q+ L
Sbjct: 128 VGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLR 187
Query: 1107 EVKPL-GEMQTDLKATGREISPREKTPEVIDATEEIDKDLEETGRREIS----PEENGPE 1161
+ L E+Q D +A ++ E DA+ E + ++S NGP
Sbjct: 188 RIAELREELQMDQQA-------KKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPM 240
Query: 1162 EV---KPVDEMETDLKTTGREGSSREKTREVIDAAEVIETDLEETEREISPQENGPEEVK 1218
V KP+ ++E + +E + V++ ++T LE ++ + QEN + K
Sbjct: 241 NVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKT-LETLQQRVKRQENLLKRCK 299
Query: 1219 P------------VGKMETDLKEIREEISQREKVLAEFSAIREKEIDLKETGKRDIPIME 1266
+ E +++ E + + EK+ A + K I K I +E
Sbjct: 300 ETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLE 359
Query: 1267 KVSGKMAVVEEMEADLKETGKENFRERGSEEICVTEEKVAELKQTGKTDISPRE------ 1320
+ G V+ E + + ET E EEI ++ ++ G+ +E
Sbjct: 360 QDKG--MVIAETKRQMHET-----LEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAA 412
Query: 1321 -NELEET-STSRQTD-------------THLMQSGSNDFSAVPSLDIQNISSEVLSMMHT 1365
ELE+ ST+++T+ ++ S + ++ + EV+ +M
Sbjct: 413 FEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKK 472
Query: 1366 PVEE-----KRNSEKEVSSHFSHFKISSQTHESDKTEVQGIQSPDVPEQFSDINLSKSLP 1420
EE ++ EKE++ QT E + E + ++ I+ K
Sbjct: 473 SSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEK--- 529
Query: 1421 QEQKPLEIKPAPFVRSRFKRPKPNLARAALKRETTESEKYIYEKKSETKKMETIVMQ-EN 1479
++Q+ L ++ + K TESE + + + E + T +++ E+
Sbjct: 530 EQQESLALEELELQK---------------KAILTESENKLRDLQQEAETYRTRILELES 574
Query: 1480 NEQTDTLPSQHDEASLMISREKDTLGHRNEEAVILPCTQTERNLSPSNSCEPKEESQSAP 1539
+ + +++ L + E + H E V++ +TE E + Q A
Sbjct: 575 SLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTE--------LESLKHQQDAL 626
Query: 1540 VQKNDSVVSVGTNNVNTFQQEMKESVIQTARQVRGRLQRPRPNI---------RKTGQRQ 1590
+ V+ +Q EM E + + Q + L + + I KT ++
Sbjct: 627 WTEKLQVLK------QQYQTEM-EKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKL 679
Query: 1591 IVDKGEAKGIIKEGRTILP---KDETEKKVLTVSNSQIETEIEVPSSAVPEHRMYENQSQ 1647
V + E + + E +L K E E VL +++ E+E H + S
Sbjct: 680 DVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDS- 738
Query: 1648 VVLVENLHVNKTNETIRHENKPYVPSSAQMTRRKFQKAKPNLGRAHSKKEEPVLEKVTTD 1707
++ + + +T + ++ + + ++ ++ K H K+ + +E + D
Sbjct: 739 IIKEHEVSIQRTEKALKDQ-----INQLELLLKERDK--------HLKEHQAHVENLEAD 785
Query: 1708 QSKEGKPEDHLLQKGASNTQLLLKEKAELLTSLEVSARKDCVGSKESALAKIDAELEEVG 1767
+ E L Q A K ++ S + SA + + E LA++ +L ++
Sbjct: 786 IKRS---EGELQQASA---------KLDVFQSYQ-SATHEQTKAYEEQLAQLQQKLLDLE 832
Query: 1768 PSRRVGEETVGDNSPSSVVEEQYLNKLTSCPQPLNETSYSKIALDGKTTISSTSEYERNR 1827
R + + V + VE Q + T E KI + + E+
Sbjct: 833 TERILLTKQVAE------VEAQKKDVCT-------ELDAHKIQVQ-----DLMQQLEKQN 874
Query: 1828 GERRSHKKFKPNVTRGRGSKRVRGKTSKKEPR----ASKAMLVTLRASQEEDDDADDFES 1883
E K ++T+ SK G +++ + + M++ +R Q+++ + +
Sbjct: 875 SEMEQKVK---SLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKL 931
Query: 1884 DYEEESYHLAPEEVNKAPVFVPVGLRSPEPVSAQIEETMEELEITVNVPDVGCIAVVEHE 1943
+E+S H+ EE ++ E ++++ +E++ T+ + A ++ E
Sbjct: 932 SAKEDSIHILNEEYE-------TKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKE 984
Query: 1944 LPNTDVTTEEMKQEENLS-VPFEMTTSEHIQDEPGTNDGSTEAAITLLT------MGDLV 1996
L NT + + +++ N + S I D + + + I LT + D++
Sbjct: 985 LENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVI 1044
Query: 1997 LQSEISSEQGDVGVCIIPHVHSKDKSHIPSSLDNVNHKIVHECQELSSPVITTSPASFEE 2056
E Q + I + ++K E EL ++ E
Sbjct: 1045 SIWEKKLNQQAEELQEIHEIQLQEKE--------------QEVAELKQKILLFGCEKEEM 1090
Query: 2057 NKIV--LEEQSSREEISLMEKVKENATPTRNTISKVTSNLRIRSRLAKPKPNLEKTLGTN 2114
NK + L+E+ +++ +L E ++ + + S ++++ L K + +L K+L N
Sbjct: 1091 NKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKEN 1150
Query: 2115 RL-------------DDYQEVSSLCVTKGAEMETQRETEKNASKATELENKNLGPVTTAE 2161
+D ++VS L ++++T E ++ + E NK+L +
Sbjct: 1151 TFLQEQLVELKMLAEEDKRKVSELT----SKLKTTDEEFQSLKSSHEKSNKSLEDKSLEF 1206
Query: 2162 NKDQSKLA 2169
K +LA
Sbjct: 1207 KKLSEELA 1214
Score = 50.4 bits (119), Expect = 2e-05
Identities = 201/1045 (19%), Positives = 412/1045 (39%), Gaps = 165/1045 (15%)
Query: 368 AHLLQKVLAEEEKRKQKSVKNHSLKEKKSTKPRKNVKVKKVACEGVNNDPDESMSSRISD 427
AHL + + + K+ + L E K KV ++ + DE S S
Sbjct: 1134 AHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSK--LKTTDEEFQSLKSS 1191
Query: 428 TERSQKDAQTVEEESLTLSREDAEQVALEVDLNQKKRRRKKQDGANELGVNNLLENATVQ 487
E+S K ++E++SL + +E++A+++D+ KK + NEL +N + ++
Sbjct: 1192 HEKSNK---SLEDKSLEFKKL-SEELAIQLDICCKKTEALLEAKTNEL-IN--ISSSKTN 1244
Query: 488 AGPSKGEKHKNKCQAIRPELKEGECSKEQM------LSCTQNIDGIVGFASTEKVEKRTD 541
A S+ +++ ++ L C+ ++ L+ QN I +T ++E++ +
Sbjct: 1245 AILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKEN 1304
Query: 542 PILSLS------------------NQQDATS----VATESSESSTSDLPSFEVGIRALCE 579
I S+ NQQ A S T+ + + ++ + + L E
Sbjct: 1305 QIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKE 1364
Query: 580 VNNAEGSCIEERNVDLK---NNSLEIDQTENVKPMLRGRFQRPKPNL-----SRAGKKSV 631
E S + ++ DL NS+ + + E LR ++ K L + K
Sbjct: 1365 -KKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDT 1423
Query: 632 LSQGKTE------------SESKNSHSKTSVEKNHVEKDKMNTLDILRMETTERENPEAE 679
LS+ K SE K + + K+ L++ E E++ E
Sbjct: 1424 LSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKD----E 1479
Query: 680 TVSVLGEKNCLQEGSQLKALRPVQVRGRLQKPKPNAGKAAERKEILISQEEIGANVEKNE 739
+++L E+ Q+ + L+ + + K + E K E+ ++ +
Sbjct: 1480 QINLLKEE-LDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKT 1538
Query: 740 NESCADRDTPQHMEDQSRKDFEEEDVILQPEKNDSFQNVQPDEPKVLNECLSVQENNKAN 799
E + + ++ Q KD E ++++ +K FQ + ++ + E E
Sbjct: 1539 IEIESLNEVLKNYNQQ--KDIEHKELV---QKLQHFQELGEEKDNRVKEA----EEKILT 1589
Query: 800 KLNQVPILRTRFQKPKPNIGRGTGRREISSKEEVLEKI--LVSGEMAAALRETVRLDTSP 857
NQV ++ + K + + SKEE L+ + + E AA L E R
Sbjct: 1590 LENQVYSMKAELETKKKELEHVN--LSVKSKEEELKALEDRLESESAAKLAELKRKAEQK 1647
Query: 858 ----KEMVPAEINTKEMQ------SDLKETGRRAISPREKILDVIDDTIEMETGLKAMGR 907
K+ + +++ KE Q S L E + + RE+ + ++++ ++ ++
Sbjct: 1648 IAAIKKQLLSQMEEKEEQYKKGTESHLSELNTK-LQEREREVHILEEKLKSVESSQSETL 1706
Query: 908 EICLREKTPEVIDATEEIDKD--LEEAGRREISP-QKNGPEEVKPLGEVETDLKATGNE- 963
+ K EE D +++ +IS Q+N E+ K L V + + T +
Sbjct: 1707 IVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSH 1766
Query: 964 --------------SSPREKTPEVTDATEEIDKNLEETGRR------KISPRENGPEEVK 1003
K E + + LEE ++ + +E G ++
Sbjct: 1767 FEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQ 1826
Query: 1004 PVDEMETDLNATGRESSPREKTPEVIDAT-EEIDL-----EETER-EVSPQENGLEEVKP 1056
+E + + +E T ++++ +E+D +E R E+ + E+++
Sbjct: 1827 AKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQA 1886
Query: 1057 LGEMETDLKATG---RDSFPRGKT----PEVIDAIE----EIEIDLEETEREISPQENGL 1105
L +M+ K T ++ + K+ P+++ +E ++E L ERE Q+ G
Sbjct: 1887 LQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAERE--KQKLGK 1944
Query: 1106 EEVKPLGEMQTDLKATGRE------ISPREKTPEVIDATEEIDKDLEETGRREISP--EE 1157
E V+ +Q DL+ +E I +E E + ++ +DLE + E
Sbjct: 1945 EIVR----LQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMRE 2000
Query: 1158 NGPEEVKPVDEMETDLKTTGREGSSREKTREVIDAAEVIETDLEETEREISPQENGPEEV 1217
+ + E+E +K T K +EV AE++E+ EET + + +++
Sbjct: 2001 FNTQLAQKEQELEMTIKET------INKAQEV--EAELLESHQEETNQLLKKIAEKDDDL 2052
Query: 1218 KPVGKMETDLKEIREE-----ISQREKVLAEFSAIREKEIDLKET-GKRDIPIME---KV 1268
K K ++ + REE + + L E +++++ +E G ++ IME ++
Sbjct: 2053 KRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQL 2112
Query: 1269 SGKMAVVEEMEADLKETGKENFRER 1293
+ K ++ ++ LKE + FRE+
Sbjct: 2113 AQKTTLIS--DSKLKE---QEFREQ 2132
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 87.0 bits (214), Expect = 2e-16
Identities = 193/993 (19%), Positives = 378/993 (38%), Gaps = 140/993 (14%)
Query: 368 AHL--LQKVLAEEEKRKQKSVKNHSLKEKKSTKPRKNVKV------KKVACEGVNNDPDE 419
AH+ L++ L EEE +QK E K K + + + K + + + D
Sbjct: 950 AHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIA 1009
Query: 420 SMSSRISDTERSQKDAQTVEEESLTLSREDAEQVALEVDLNQK-KRRRKKQDGA------ 472
SS++++ E K+ + + + + E++ E Q+ ++ ++K DG
Sbjct: 1010 ECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQD 1069
Query: 473 ---------NELGVNNLLENATVQAGPSKGEK---HKNKCQAIRPELKEGECSKEQMLSC 520
+EL + + +Q ++G+ HKN + EL+ ++
Sbjct: 1070 QIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFES 1129
Query: 521 TQNIDGIVGFASTEKVEKRTDPI--------LSLSNQQDATSVATESSESSTSDLPSFEV 572
+ AS K EK+ + L + D T+ E ++ +
Sbjct: 1130 EK--------ASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKK 1181
Query: 573 GIRALCEVNNAEGSCIEERNVD-LKNNSLEIDQTENVKPMLRGRFQRPKP-NLSRAGKKS 630
+ + + A+ + +R+ L+ S +++Q + K L Q + N A +
Sbjct: 1182 ALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVK 1241
Query: 631 VLSQGKTESESKNSHSKTSVEKNHVEKDKMNTLDILRMETTERENPEAETVSVLGEKNCL 690
VL Q K ESE K V++ H + + + L + E + E + VS L E+
Sbjct: 1242 VLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEE--- 1298
Query: 691 QEGSQLKALRPVQVRGRLQKPKPNAGKAAERKEILISQEEIGANVEKNENESCADRDTPQ 750
AE+K I +++ + + + +T Q
Sbjct: 1299 ----------------------------AEKKGIKFAKDAASLESQLQDTQELLQEETRQ 1330
Query: 751 HMEDQSR-KDFEEEDVILQPEKNDSFQNVQPDEPKVLNECLSVQENNKANKLNQVPILRT 809
+ SR + EEE LQ ++ + +E + N QV L++
Sbjct: 1331 KLNLSSRIRQLEEEKNSLQEQQEE-------------------EEEARKNLEKQVLALQS 1371
Query: 810 RFQKPKPNIGRGTGRREISSKEEVLEKILVSGEMAAALRETVRLDTSPKEMVPAEINTK- 868
+ K + G I S EE +K+L E + E L E + +
Sbjct: 1372 QLADTKKKVDDDLGT--IESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQEL 1429
Query: 869 -EMQSDLKETGRRAISPREKILDVIDDTIEMETGLKAMGREICLREKTPEVIDATEEIDK 927
++ DL R+ S EK D + E + A E E+ +A E+ K
Sbjct: 1430 DDLTVDLDHQ-RQVASNLEKKQKKFDQLLAEEKSISARYAE----ERDRAEAEAREKETK 1484
Query: 928 DLEEAGRREISPQKNGPEEVKPLGEVETDLKATGNESSPREKTPEVTDATEEIDKNLEET 987
L A E E ++ E E K R ++ + +++ KN+ E
Sbjct: 1485 ALSLARALE--------EALEAKEEFERQNKQL------RADMEDLMSSKDDVGKNVHEL 1530
Query: 988 GRRKISPRENGPEEVKPVDEMETDLNATGRESSPREKTPEVIDATEEIDLEETEREVSPQ 1047
+ K + + E ++E+E +L AT E + + A E DL+ + + +
Sbjct: 1531 EKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEK 1590
Query: 1048 ENGLEEVKPLGEMETDLKATGRDSFPRGKTPEVIDAIEEIEIDLEETEREISPQENGLEE 1107
+ L +K + E+E +L+ R + + + +++EIDL++ E +I +E
Sbjct: 1591 KRLL--IKQVRELEAELED------ERKQRALAVASKKKMEIDLKDLEAQIEAANKARDE 1642
Query: 1108 V-KPLGEMQTDLKATGREI-SPREKTPEVIDATEEIDKDLE--ETGRREISPEENGPEEV 1163
V K L ++Q +K RE+ R E+ ++E +K L+ E ++ E E
Sbjct: 1643 VIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERA 1702
Query: 1164 KPVDEMETDLKTTGREGSSREKTREVIDAAEVIETDLEETEREISPQENGPEEV-----K 1218
+ E E D S+ K+ ++D +E + + E E+ +++ E + K
Sbjct: 1703 RRHAEQERDELADEITNSASGKS-ALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRK 1761
Query: 1219 PVGKMETDLKEIREEISQREKVLAEFSAIREKEIDLK-ETGKRDIPIMEKVSGKMAVVEE 1277
+++T E+ E S +K + + +LK + + + + K ++ +E
Sbjct: 1762 TTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEA 1821
Query: 1278 MEADLKETGKENFRERGSEEICV--TEEKVAEL 1308
L+E ++ +ER + V TE+K+ E+
Sbjct: 1822 KIGQLEEQLEQEAKERAAANKLVRRTEKKLKEI 1854
Score = 52.4 bits (124), Expect = 6e-06
Identities = 119/643 (18%), Positives = 240/643 (37%), Gaps = 45/643 (6%)
Query: 372 QKVLAEEEKRK--------QKSVKNHSLKEKKSTKP--RKNVKVKKVACEGVNNDPDESM 421
Q++L EE ++K Q + +SL+E++ + RKN++ + +A + D + +
Sbjct: 1321 QELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKV 1380
Query: 422 SSRISDTERSQKDAQTVEEESLTLSREDAEQVALEVDLNQKKRRRKKQDGANELGVNNLL 481
+ E ++ + + +++ LS+ E+ AL D +K + R +Q+ ++L V+ L
Sbjct: 1381 DDDLGTIESLEEAKKKLLKDAEALSQR-LEEKALAYDKLEKTKNRLQQE-LDDLTVD-LD 1437
Query: 482 ENATVQAGPSKGEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGIVGFASTEKVEKRTD 541
V + K +K ++ A + + + +E+ +
Sbjct: 1438 HQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALE 1497
Query: 542 PILSLSNQQDATSVATESSESSTSDLPSFEVGIRALCEVNNAEGSCIEERNVDLKNNSLE 601
Q E SS D+ + L + A +EE L+ E
Sbjct: 1498 AKEEFERQNKQLRADMEDLMSSKDDVGK---NVHELEKSKRALEQQVEEMRTQLEELEDE 1554
Query: 602 IDQTENVKPMLRGRFQRPKPNLSRAGKKSVLSQGKTESESKNSHSKTSVEKNHVEKDKMN 661
+ TE+ K L Q K R L ++E K V + E +
Sbjct: 1555 LQATEDAKLRLEVNMQAMKAQFERD-----LQTRDEQNEEKKRLLIKQVRELEAELEDER 1609
Query: 662 TLDILRMETTERENPEAETVSVLGEKNCLQEGSQLKALRPVQVRGRLQKPKPNAGKAAER 721
L + + ++ + + + E +K LR +Q + + + + +A+ R
Sbjct: 1610 KQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARAS-R 1668
Query: 722 KEILISQEEIGANVEKNENESCADRDTPQHMEDQSRKDFEEEDVILQPEKND-SFQNVQP 780
EI +E ++ E E ++ E R +E D + N S ++
Sbjct: 1669 DEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALL 1728
Query: 781 DEPKVLNECLSVQENNKANKLNQVPILRTRFQKPKPNIGRGTGRREISSKEEVLEKILVS 840
DE + L ++ E + + + +L RF+K + + L L +
Sbjct: 1729 DEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQV-------------DTLNAELAA 1775
Query: 841 GEMAAALRETVR--LDTSPKEMVPAEINTKEMQSDLKETGRRAISPREKILDVIDDTIEM 898
AA + R L+ KE+ + +E++ +K + IS E + +++ +E
Sbjct: 1776 ERSAAQKSDNARQQLERQNKEL---KAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQ 1832
Query: 899 ETGLKAMGREICLR--EKTPEVIDATEEIDKDLEEAGRREISPQKNGPEEVKPLGEVETD 956
E +A ++ R +K E+ E+ + ++ + + + L E E +
Sbjct: 1833 EAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEE 1892
Query: 957 LKATGNESSPREKTPEVTDATEEIDKNLEETGRRKISPRENGP 999
AT +S R+ E+ DATE + E K R GP
Sbjct: 1893 --ATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGP 1933
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 80.9 bits (198), Expect = 2e-14
Identities = 249/1358 (18%), Positives = 540/1358 (39%), Gaps = 238/1358 (17%)
Query: 497 KNKCQAIRPELKEGECSKEQMLSCTQNIDGIVGFASTEKVEKRTDPILSLSNQQDATSVA 556
+ + Q ++ LKE + E++ + G+ ++ E + D +++ S S
Sbjct: 89 RQEVQDLQASLKEEKWYSEELKKELEKYQGL------QQQEAKPDGLVTDS------SAE 136
Query: 557 TESSESSTSDLPSFEVGIRALCEVNNAEGSCIEERNVDLKNNSLEIDQTENVKPMLRGRF 616
+S E + + I+ + ++ + + + D+K+ + D+ +++ +
Sbjct: 137 LQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKS---KYDEERSLREAAEQKV 193
Query: 617 QRPKPNLSRAGKKSVLSQGKTESESKNSHSKTSVEKNHVEKDK--MNTLDILRMETTERE 674
R L++ + +V+ KTE + +V K + + + M+ + + R +E+
Sbjct: 194 TRLTEELNK--EATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKL 251
Query: 675 NPEAETVS---VLGEKNCLQEGSQLKALRPVQVR---GRLQKPKPNAGKAAERK----EI 724
E + + E Q S+L A P +V LQK K + + ++ E
Sbjct: 252 KDECKKLQSQYASSEATISQLRSEL-AKGPQEVAVYVQELQKLKSSVNELTQKNQTLTEN 310
Query: 725 LISQEEIGANVEKNENESCADRDTPQ---HMED------QSRKDFEEEDV----ILQPEK 771
L+ +E+ +E+ NE + Q H +D QSR E + + EK
Sbjct: 311 LLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEK 370
Query: 772 NDSFQNVQPD-------------EPKVLNECLSVQENNKANKLNQVPILRTRFQKPKPNI 818
++ Q ++ + E K L + +E + +++ L ++ + + +
Sbjct: 371 GEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQL 430
Query: 819 GRGTGR----REISSKEEVLEKILVSGEMAAALR-ETVRLDTSPKEMVPAEINTKEMQSD 873
G GR R++SS EK++ + A L+ + RL+ KE V N+ E+Q
Sbjct: 431 GEAHGRLKEQRQLSS-----EKLMDKEQQVADLQLKLSRLEEQLKEKVT---NSTELQHQ 482
Query: 874 LKETG-----------------RRAISPREKILDVIDDTIEMETGLKAMGREICLREKTP 916
L +T R A + E++L I D + L+A L +K+
Sbjct: 483 LDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEA------LLQKSK 536
Query: 917 EVIDATEEIDKDLE---EAGRREISPQKNGPEEVKPLGEVETDL--KATGNESSPREKTP 971
E I E+ +DL +AG E + E+ L E T L K S ++
Sbjct: 537 ENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQE 596
Query: 972 EVTDATEEIDKNLE---------ETGRRKISPRENGPEEVKPVDEMETDLNATGRE--SS 1020
+ D +E +L ET +++ + N E + V +++ + A S+
Sbjct: 597 NLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLN--ESKEKVSQLDIQIKAKTELLLSA 654
Query: 1021 PREKTPEVIDATEEID-----LEETEREVSPQENGLEEV--------KPLGEMETDLKAT 1067
KT + D +D L++ ++E++ L++V + ++E+ LK
Sbjct: 655 EAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEY 714
Query: 1068 GRDSFP-RGKTPEVIDAIEEIEIDLEETEREISPQENGLEEVKPLGEMQTDLKATGREIS 1126
KT E+ I+++E D E + + +E L++++ ++ TDL+ E+S
Sbjct: 715 KEKYLSLEQKTEELEGQIKKLEADSLEVK---ASKEQALQDLQQQRQLNTDLELRATELS 771
Query: 1127 PREKTPEVIDATEEIDKDLEETGRREISPEENGPEEVKPVDEMETDLKTTGREGSSREKT 1186
+ E++K++ + R ++ + E +K +K
Sbjct: 772 KQ----------LEMEKEIVSSTRLDLQKKSEALESIK-------------------QKL 802
Query: 1187 REVIDAAEVIETDLEETEREISPQENGPEEVKPVGKMETDLKEIREEISQREKVLAEFSA 1246
+ + ++++ D E +E Q EE+ +++T + E+++ ++E ++ E S
Sbjct: 803 TKQEEEKQILKQDFETLSQETKIQH---EELN--NRIQTTVTELQKVKMEKEALMTELST 857
Query: 1247 IREKEIDLKETGKRDIPIMEKVS--GKMAVVE------EMEADLKETGKENFRERGSEEI 1298
+++K + ++ K EK + GK A+++ E++ L+ + +E+ +E+
Sbjct: 858 VKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQ--KEL 915
Query: 1299 CVTEEKVAELKQTGKTDISPRENEL---EETSTSRQTDTHLMQSGSNDF---SAVPSLDI 1352
+ EK E K +++ + +L + T + + +Q N+ S I
Sbjct: 916 KKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQI 975
Query: 1353 QNISSE--VLSMMHTPVEEKRNSE-----KEVSSHFSHFKISSQTHESDKTEVQGIQSPD 1405
+ + E + + T +E K + +E+++ + +E + + +QS
Sbjct: 976 EALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDF 1035
Query: 1406 VPEQFSDINLSKSLPQEQKPLEIKPAPFVRSRFKRPKPNLARAALKRETTESEKYIYEKK 1465
+ + + L ++ L + + +R + N LK + K E+
Sbjct: 1036 YGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELK-----TAKATLEQD 1090
Query: 1466 SETKKMETIVMQENNEQTDTLPSQHDEASLMISREKDTLGHRNEEAVI--LPCTQTERNL 1523
S K+ Q+ E+ L E SL +EK+ + +++ A I + C Q E+ +
Sbjct: 1091 SAKKE------QQLQERCKALQDIQKEKSL---KEKELVNEKSKLAEIEEIKCRQ-EKEI 1140
Query: 1524 SPSNSCEPKEESQSAPVQKNDSVVSVGTNNVNTFQQEMKESVIQTARQVRGRLQRPRPNI 1583
+ N EE +S K +S+ + T ++ K+ +IQ +++G+ + +
Sbjct: 1141 TKLN-----EELKS---HKLESIKEI------TNLKDAKQLLIQQKLELQGKADSLKAAV 1186
Query: 1584 RKTGQRQIVDKGEAKGIIKEGRTILPKDETEKKVLTVSNSQIETEIEVPSSAVPEHRMYE 1643
+ + Q + K + K ++E KK +++ +EI+ + +H E
Sbjct: 1187 EQEKRNQQILKDQVK----------KEEEELKKEFIEKEAKLHSEIKEKEVGMKKHE--E 1234
Query: 1644 NQSQVVLVENLHVNKTNETIRHENKPYVPSSAQMTRRKFQKAKPNLGRAHSKKEEPVLEK 1703
N++++ + + NE + K + S+Q + +K +L + E VLE
Sbjct: 1235 NEAKL----TMQITALNENLGTVKKEW--QSSQRRVSELEKQTDDL-----RGEIAVLEA 1283
Query: 1704 VTTDQSKEGKPEDHLLQKGASNTQLLLKEKAELLTSLE 1741
+ E + KG + L + EL L+
Sbjct: 1284 TVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLD 1321
Score = 51.6 bits (122), Expect = 1e-05
Identities = 186/1030 (18%), Positives = 408/1030 (39%), Gaps = 190/1030 (18%)
Query: 1220 VGKMETDLKEIREEISQREKVLAEFSAIREKEIDLKETGKRDIPIMEKVSGKMAVVEEME 1279
V ++ LKE + + +K L ++ ++++E K G V+ A ++ +E
Sbjct: 92 VQDLQASLKEEKWYSEELKKELEKYQGLQQQEA--KPDGL--------VTDSSAELQSLE 141
Query: 1280 ADLKETGKENFRERGSEEICVTEEKVAELKQTGKTDISPRENELEETSTSRQTDTHLMQS 1339
L+E ENF + +++ E+K A+L T+I+ +++ +E + R+ +
Sbjct: 142 QQLEEAQTENFNIKQMKDLF--EQKAAQLA----TEIADIKSKYDEERSLREAAEQKVTR 195
Query: 1340 GSNDFSAVPSLDIQNISSEVLSMMHTPVEEKRNSEKEVSSHFSHFKISSQTHESDKTEVQ 1399
+ + + ++ IQ++ +E+L +E+ +KE+ +VQ
Sbjct: 196 LTEELNKEATV-IQDLKTELLQ--RPGIEDVAVLKKEL------------------VQVQ 234
Query: 1400 GIQSPDVPEQFSDINLSKSLPQEQKPLEIKPAPFVRSRFKRPKPNLA--RAALKRETTES 1457
+ E+ + S+ L E K L+ S++ + ++ R+ L + E
Sbjct: 235 TLMDNMTLERERE---SEKLKDECKKLQ--------SQYASSEATISQLRSELAKGPQEV 283
Query: 1458 EKYIYEKKSETKKMETIVMQENNEQTDTLPSQHDEASLMISREKDTLGHRNEEAVI---- 1513
Y+ E + + + + + L + D L ++++ +N +A +
Sbjct: 284 AVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKD 343
Query: 1514 LPCTQTERNLSPSNSC------EPKEESQSAPVQKND-SVVSVGTNNVNT-FQQ--EMKE 1563
L C Q + LS S + E E+ ++ K + S V ++ F+Q + +E
Sbjct: 344 LDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQRE 403
Query: 1564 SVIQTARQVRGRLQRPRPNIRKTGQRQIVDKGEAKGIIKEGRTI----LPKDETEKKVLT 1619
Q Q++ + + + +T +RQ+ GEA G +KE R + L E + L
Sbjct: 404 EKEQHGLQLQSEINQLHSKLLET-ERQL---GEAHGRLKEQRQLSSEKLMDKEQQVADLQ 459
Query: 1620 VSNSQIETEIE--VPSSAVPEHRMYENQSQVVLVENLHVNKTNETIRHENKPYVPSSAQM 1677
+ S++E +++ V +S +H++ + + Q H+ + + S
Sbjct: 460 LKLSRLEEQLKEKVTNSTELQHQLDKTKQQ-----------------HQEQQALQQS--- 499
Query: 1678 TRRKFQKAKPNLGRAHSKKEEPVLEKVTTDQSKEGKPEDHLLQKGASNTQLLLKEKAELL 1737
T K ++A+ +L E VL ++ D+ ++ + + LLQK N LL KE+ +L
Sbjct: 500 TTAKLREAQNDL--------EQVLRQIG-DKDQKIQNLEALLQKSKENISLLEKEREDLY 550
Query: 1738 TSLEVSARKDCVGSK--------ESALAKIDAELEEVGPSRRVGEETVGDNSPSS----- 1784
++ + V ++ + + ++ +L+ S + +E + D
Sbjct: 551 AKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLR 610
Query: 1785 VVEEQYLNKLTSCPQ---PLNET----SYSKIALDGKTTISSTSEYER--NRGERRSHKK 1835
+++ L+ TS + LNE+ S I + KT + ++E + R + ++H
Sbjct: 611 AAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLD 670
Query: 1836 FKPNVTRGRGSKRVRGKTSKKEPRASKAMLVTLRASQEEDDDADDFESDYEEESYHLAPE 1895
N + + + + T + A L+ QE + +Y+E+ L
Sbjct: 671 TAQNALQDKQQELNKITTQLDQVTAK------LQDKQEHCSQLESHLKEYKEKYLSL--- 721
Query: 1896 EVNKAPVFVPVGLRSPEPVSAQIEETMEELEITVNVPDVGCIAVVEHELPNTDVTTEEMK 1955
E+ EELE + + + V + + ++++
Sbjct: 722 -----------------------EQKTEELEGQIKKLEADSLEV----KASKEQALQDLQ 754
Query: 1956 QEENLSVPFEMTTSEHIQDEPGTNDGSTEAAITLLTMGDLVLQSE-ISSEQGDVGVCIIP 2014
Q+ L+ E+ +E + E I T DL +SE + S + +
Sbjct: 755 QQRQLNTDLELRATEL------SKQLEMEKEIVSSTRLDLQKKSEALESIKQKL------ 802
Query: 2015 HVHSKDKSHIPSSLDNVNHKIVHECQELSSPVITTSPASFEENKIVLEEQSSREEISLME 2074
++K + + ++ + + +EL++ + TT E K+ +E+++ E+S
Sbjct: 803 TKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVT---ELQKVKMEKEALMTELS--- 856
Query: 2075 KVKENATPTRNTISKVTSNLRIRSRLAKPK-PNLEKTLGTNRLDDYQEVSSLCVTKGAEM 2133
VK+ + +++ S ++ K +LEKT + Q + + E+
Sbjct: 857 TVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELK-HQLQVQMENTLKEQKEL 915
Query: 2134 ETQRETEKNASKATELE-NKNLGPVTTAENKDQSKLACVHGIKGTSISSEVNLTERNENQ 2192
+ E EK AS +LE N + A+N + ++G N+ E ++
Sbjct: 916 KKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQG-------NINELKQSS 968
Query: 2193 EESSQEVHML 2202
E+ +++ L
Sbjct: 969 EQKKKQIEAL 978
>gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]
Length = 1088
Score = 79.0 bits (193), Expect = 6e-14
Identities = 159/832 (19%), Positives = 330/832 (39%), Gaps = 140/832 (16%)
Query: 606 ENVKPMLRGRFQRPKPNLSRAGKKSVLSQGKTESESKNSH-SKTSVEKNHVE-----KDK 659
E K L R + K L K + ++ E + ++ + +H+E K+K
Sbjct: 296 ETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEK 355
Query: 660 MNTLDILRMETTER-----ENPEAETVSVLGEKNCLQEGSQLKALRPVQVRGRLQKPKPN 714
N++ LR E R ++ + + + + E + S + LR ++ +Q K N
Sbjct: 356 ENSM--LREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEE--IQMLKSN 411
Query: 715 AGKAAERKEILISQEEIGANVEKNENESCADRDTPQHMEDQSRKDFEEEDVILQPEKNDS 774
+ E +E + Q E+ + K Q ++ SRKD E ++ K ++
Sbjct: 412 GALSTEEREEEMKQMEVYRSHSKFMKNKIG-----QVKQELSRKDTE---LLALQTKLET 463
Query: 775 FQNVQPDEPK---VLNECLSVQENNKANKLNQVPILRTRFQKPKPNIGRGTGRREISSKE 831
N D + VL E L+ +E A +V LR R ++ + + + T + + ++E
Sbjct: 464 LTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEE 523
Query: 832 EVLEKILVSGEMAAALRETV-RLDTSPKEMVPAEINTKEMQSDLKETGRRAISPREKILD 890
+ G A + + LD +++ + + +Q L++ ++ S +E++
Sbjct: 524 K--------GTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKS 575
Query: 891 VIDDTIEMETGLKAMGREICLREKTPEVIDATEEIDKDLEEAGRREISPQKNGPEEVKPL 950
+ DT +T L + + +E+T E + E+ D+D
Sbjct: 576 LQADTTNTDTALTTLEEALAEKERTIERLK--EQRDRD---------------------- 611
Query: 951 GEVETDLKATGNESSPREKTPEVTDATEEIDKNLEETGRRKISPRENGPEEVKPVDEMET 1010
REK E+ + +++ K+L+E K+S + E K ++
Sbjct: 612 ---------------EREKQEEIDNYKKDL-KDLKE----KVSLLQGDLSE-KEASLLDL 650
Query: 1011 DLNATGRESSPREKTPEVIDATEEIDLEETEREVSPQENGLEEVKPLGEMETDLKATGRD 1070
+A+ SS +K + T EI LE+ + E +ME+ LK
Sbjct: 651 KEHASSLASSGLKKDSRL--KTLEIALEQKKEECL-------------KMESQLKKAHEA 695
Query: 1071 SFPRGKTPEVIDAIEEIEIDL----EETEREISPQENGLEEVKPLGEMQTD----LKATG 1122
+ +PE+ D I+ +E ++ +E+ + + + LE +K + + D +
Sbjct: 696 ALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELE 755
Query: 1123 REISPREKTPEVIDATEEIDKD-----LEETGRREISPEENG---PEEVKPVDEMETDLK 1174
R++ + K + E+++K LEE RRE + ++ + ++ D+ +L+
Sbjct: 756 RQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELE 815
Query: 1175 TTGREGSSREKTREVIDAAEVIETDLEETEREISPQENGPEEVK-PVGKMETDLKEIREE 1233
RE RE++ A E E+ E+++ E+VK + M+ L ++
Sbjct: 816 EALRESVQITAEREMVLAQE--ESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQS 873
Query: 1234 ISQREKVLAEFSAIREKEIDLKETGKRDIPIME-KVSGKMAVVEEMEADLKETGKENFRE 1292
++++E L A R K ++ ++E K +A + E +A++ + ++
Sbjct: 874 LAEKETHLTNLRAERRKHLE---------EVLEMKQEALLAAISEKDANIALLELSSSKK 924
Query: 1293 RGSEEICVTEEKVAELKQTGKTDISPRENELEETSTSRQTDTHLMQSGSNDFSAVPSLDI 1352
+ EE+ + + L Q K R + + D H S SN + PS D
Sbjct: 925 KTQEEVAALKREKDRLVQQLKQQTQNRMKLMAD----NYEDDHFKSSHSNQTNHKPSPD- 979
Query: 1353 QNISSEVLSMMHTPVEEKRNSEKEVSSHFSHFKISSQTHESDKTEVQGIQSP 1404
+ P+ E + ++ + H +++ H+ D ++G+ P
Sbjct: 980 ---------QIIQPLLELDQNRSKLKLYIGH--LTTLCHDRDPLILRGLTPP 1020
Score = 39.3 bits (90), Expect = 0.052
Identities = 182/912 (19%), Positives = 351/912 (38%), Gaps = 162/912 (17%)
Query: 951 GEVETDLKATGNESSPREKTPEVTDATEEI-DKNLEETGRRKISPRENGPEEVKPVDEME 1009
G + ++ T SSP + V T + +L P + +++
Sbjct: 96 GRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQ 155
Query: 1010 TDLNATGRESSPREKTPEVIDATEEIDLEETEREVSPQ---ENGL--EEVKPLGEMETDL 1064
T L RE+ K EV ++ + + SP+ E L +E + +
Sbjct: 156 TQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQY 215
Query: 1065 KATGRDSFPRGKTPEVIDAIEEIEIDLEETEREISPQENGLEEVKPLGE-----MQTDLK 1119
+ ++ T + + I+ DL + ++ S G V L E + + +
Sbjct: 216 RVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHE 275
Query: 1120 ATGREISPREKTPEVIDATEEIDKDLEETGRREISPEENGPEEVKPVDEMETDLKTTGRE 1179
+E+ KT E ++ E K + R+ E +K + EM L++ G
Sbjct: 276 RQAKELFLLRKTLEEMELRIETQK--QTLNARD--------ESIKKLLEM---LQSKGLS 322
Query: 1180 GSS----REKTREVIDA---AEVIETDLEETEREISPQ--------ENGPEEVKP----- 1219
+ E+TR + +A +E+ LE+ E+E S EN P+ K
Sbjct: 323 AKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQT 382
Query: 1220 --------VGKMETDLKEIREEISQREKVLAEFSAIREKEIDLKETGKRDIPIMEKVSGK 1271
+ ME L+++ EEI + A + RE+E+ E + M+ G+
Sbjct: 383 VIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQ 442
Query: 1272 MAV------VEEMEADLKETGKENFRERGSEEICVTEEKVAELKQTG---KTDISPRENE 1322
+ E + K N + I V +E + +Q +T++
Sbjct: 443 VKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLR 502
Query: 1323 LEETSTSRQTDTHLMQSGSND--------FSAVPSLDIQNISSEVLSMMHTPVEEK-RNS 1373
LEE T T +Q + + LD++ VL ++E+ R+
Sbjct: 503 LEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDK 562
Query: 1374 EKEVSSHFSHFKISSQTHESDKTEVQGIQSPDVPEQFSDINLSKSLPQEQKPLEIKPAPF 1433
EK++SS K V+ +Q+ + L ++L ++++ +E
Sbjct: 563 EKQMSSL--------------KERVKSLQADTTNTDTALTTLEEALAEKERTIE------ 602
Query: 1434 VRSRFKRPKPNLARAALKRETTESEKYIYEKKSETKKME---TIVMQENNEQTDTLPSQH 1490
R K + R+ E ++ I K + K ++ +++ + +E+ +L
Sbjct: 603 ---RLKEQR--------DRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLK 651
Query: 1491 DEASLMISR--EKDT--------LGHRNEEAVILPCTQTERNLSPSNSCEPKEESQSAPV 1540
+ AS + S +KD+ L + EE C + E L ++ E E++++P
Sbjct: 652 EHASSLASSGLKKDSRLKTLEIALEQKKEE-----CLKMESQLKKAH--EAALEARASP- 703
Query: 1541 QKNDSVVSVGTNNVNTFQQEMKESVIQTARQVRGRLQRPRPNIRKTGQRQIVDKGEAKGI 1600
+ +D + + + ++ E ++ + R + I K + + DK K I
Sbjct: 704 EMSDRIQHL-EREITRYKDESSKAQAEVDRLL---------EILKEVENEKNDKD--KKI 751
Query: 1601 IKEGRTILPKDETEKKVLTVSNSQIETEIEVPSSA--VPEHRMYE---NQSQVVLVENLH 1655
+ R + KD+ +K V+N + + ++E SA + E R E N S L ++L
Sbjct: 752 AELERQV--KDQNKK----VANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSL- 804
Query: 1656 VNKTNETIRHENKPYVPSSAQMT-RRKFQKAKPNLGRAHSKKEEPVLEKVTTDQSKEGKP 1714
K ++ I E + + S Q+T R+ A+ R +++K+ +E++ K K
Sbjct: 805 -RKKDDRI-EELEEALRESVQITAEREMVLAQEESARTNAEKQ---VEELLMAMEKV-KQ 858
Query: 1715 EDHLLQKGASNTQLLLKEKAELLTSLEVSARK---DCVGSKESALAKIDAE------LEE 1765
E ++ S+TQ L EK LT+L RK + + K+ AL +E L E
Sbjct: 859 ELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLE 918
Query: 1766 VGPSRRVGEETV 1777
+ S++ +E V
Sbjct: 919 LSSSKKKTQEEV 930
>gi|118498368 kinectin 1 isoform c [Homo sapiens]
Length = 1300
Score = 78.6 bits (192), Expect = 8e-14
Identities = 260/1372 (18%), Positives = 531/1372 (38%), Gaps = 179/1372 (13%)
Query: 364 FDFFAHLLQKVLAEE----EKRKQKSVKNHSLKEKKSTKPRKNVKVKKVACEGVNNDPDE 419
F FF +++ L +E +KR+QK + + K+K K K +++ N + E
Sbjct: 22 FLFFWLFMKETLYDEVLAKQKREQKLIPTKTDKKKAEKKKNKKKEIQ-------NGNLHE 74
Query: 420 SMSSRISDTERSQKDAQTVEEESLTLSREDAEQVALEVDLNQKKRRRKKQDGANELGVNN 479
S S + + DA VE++ ++ V + ++K++ KKQ E
Sbjct: 75 SDSESV-PRDFKLSDALAVEDDQ--VAPVPLNVVETSSSVRERKKKEKKQKPVLE---EQ 128
Query: 480 LLENATVQAGPSKGEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGIVGFASTEKVEKR 539
+++ + P K + + P + K+ ++N ++ +K+
Sbjct: 129 VIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKN--------GSDDQDKK 180
Query: 540 TDPILSLSNQQDATSVATESSESSTSDLPSFEVGIRALCEVNNAEGSCIEERNVDLKNNS 599
+ ++ S +Q+A + E+ + S S +A + E ++E +
Sbjct: 181 VETLMVPSKRQEALPLHQETKQESGSGKK------KASSKKQKTENVFVDEPLIHATTYI 234
Query: 600 LEIDQTENVKPMLRGR--FQRPKPNLSRAGKKSVLSQGKTESESKNSHSK-----TSVEK 652
+D ++ P++ R KP+ +KS + KTE++ +N+ K S++
Sbjct: 235 PLMDNADS-SPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKT 293
Query: 653 NHVEKDK-MNTLDILR-----METTERENPEAETVSVLGEKNCLQEGSQLKAL------- 699
+D+ + +D+L+ ++ +++ + E +++ + LQE +L A
Sbjct: 294 MMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQ---LQEKDKLLAAVKEDAAA 350
Query: 700 ---RPVQVRGRLQKPKPNAGKAAERKEILISQEEIGANVEKNE-NESCADRDTPQHMEDQ 755
R Q+ + K + R + I E NV +N+ + S + Q Q
Sbjct: 351 TKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQ 410
Query: 756 SRKDFE-------EEDVILQPEKNDSFQNVQPDEPKVLNEC------LSVQENNKANKLN 802
R+ E +E+ IL+ +++ ++ + LN+ L + K KL
Sbjct: 411 VREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQ 470
Query: 803 QVPILRTRFQKPKPNIGRGTGRREISSKEEVLEKILVSGEMAAALRETVRLDTSPKEMVP 862
Q + + ++ + + ++ E E++ A E + D K V
Sbjct: 471 QEEVQKKNAEQAATQL-----KVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSK-FVA 524
Query: 863 AEINTKEMQSDLKETGRRAISPREKILDVIDDTIEMETGLKAMGREICLREKTPEVIDAT 922
E + + S L +T ++++ + ME+ K + +E L+ + ++++
Sbjct: 525 KENEVQSLHSKLTDTLVSKQQLEQRLMQL------MESEQKRVNKEESLQMQVQDILEQN 578
Query: 923 EEIDKDLEEAGRREISPQKNGPEEVKPLGEV--ETDLKATGNESSPREKTPEVTDATEEI 980
E + +++ +I+ Q + + L +V E D + E S + +T EE+
Sbjct: 579 EALKAQIQQF-HSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEEL 637
Query: 981 DKNLEETGRRKISPRENGPEEVKPVDEMETDLNATGRESSPREKTPEVIDATEEIDLEET 1040
K+++ EV+ + + + A E +++ V D + E+
Sbjct: 638 -KDIQNMNFLL-------KAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQL 689
Query: 1041 EREVSPQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEVIDAIEEIEIDLEETEREISP 1100
+ E+S N +EE K L + LK+ + D +E++E ++E + ++
Sbjct: 690 QHEIS---NKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKT 746
Query: 1101 QENGLEE-VKPLGEMQTDLKATGREISPREKTPEVIDATEEID---KDLEETGRREISPE 1156
E LE + + + +L A E S K + + A + L E ++ I +
Sbjct: 747 VEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEK 806
Query: 1157 ENGPEEVKPVDEMETDLKTTGREGSSREKTREVIDAAEVIETDLEETEREISPQENGPEE 1216
+ + V+ + E E LK +E + ++ +E+ E I E +++S
Sbjct: 807 DGKIKSVEELLEAEL-LKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLS-------I 858
Query: 1217 VKPVGKMETDLKEIREEISQREKVLAEFSAIREKEIDLKETGKRDIPIMEKVSGKMAVVE 1276
V +++ LK E+++ + VL EKE DL TGK + E+ E
Sbjct: 859 TSKVQELQNLLKGKEEQMNTMKAVL------EEKEKDLANTGKWLQDLQEE-------NE 905
Query: 1277 EMEADLKETGKENFRERGS----EEI-CVTEEKVAELKQTGKTDISPRENELEETSTSRQ 1331
++A ++E + N +E S EE+ V +EK ELK+ E L+E +
Sbjct: 906 SLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRL--------EAMLKERESDLS 957
Query: 1332 TDTHLMQSGSND----FSAVPSLDIQNISSEVLSMMHTP-VEEKRNSEKEVSSHFSHF-K 1385
+ T L+Q ++ S + L QN H ++ EKE+S ++
Sbjct: 958 SKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDS 1017
Query: 1386 ISSQTHESDKTEVQGIQSPDVPEQFSDINLSKSLPQEQKPLEIKPAPFVRSRFKRPKPNL 1445
+ K + Q + E + L K P+ P + ++ K+ K +
Sbjct: 1018 LKDAVEHQRKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECM 1077
Query: 1446 ARAALKRET------------------TESEKY---IYEKKSETKKMETIVMQENNEQTD 1484
A + E E EKY + E + +K++ V QE N+
Sbjct: 1078 AGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKV 1137
Query: 1485 TLPSQHDEASLM----ISREKDTLGHRNEEAVILPCTQTERNLSPSNSCEPKEESQSAPV 1540
+ H M S E++ R+E I + +L + E + A +
Sbjct: 1138 KVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHL--------EMELEKAEM 1189
Query: 1541 QKNDSVVSVGTNNVNTFQQEMKESVIQTARQ-VRGRLQRPRPNIRKTGQRQIVDKGEAKG 1599
+++ V V + K Q RQ V G L + + ++ + + G+
Sbjct: 1190 ERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTV 1249
Query: 1600 IIKEGRTILPKDE-TEKKVLTVSNSQIETEIEVPSSAVPEHRMYENQSQVVL 1650
I E + P+ E +EK+ ++VS +Q T+++ AV + E + VL
Sbjct: 1250 I--ENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVL 1299
Score = 66.6 bits (161), Expect = 3e-10
Identities = 154/792 (19%), Positives = 322/792 (40%), Gaps = 93/792 (11%)
Query: 1008 METDLNATGRESSPREKTPEVIDATEEI--DLEETEREVSPQENG---LEEV-KPLGEME 1061
ME++ +E S + + ++++ E + +++ +++ Q + EE+ K + E +
Sbjct: 554 MESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKD 613
Query: 1062 TDLKATGRDSFPRGKTPEVIDAIEEIEIDLEETEREISPQENGL--EEVKPLGEMQTDLK 1119
+K T DS A E + +E E + N L EV+ L + +
Sbjct: 614 KQIKQT-EDSL----------ASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQA 662
Query: 1120 ATGREISPREKTPEVIDATEEIDKDLEETGRREISPEENGPEEVKPVDEMETDLKTTGRE 1179
A E+ EK + + ++ + LEE + EIS N EE K +++ LK+ ++
Sbjct: 663 AAAHEL---EKMQQSVYVKDDKIRLLEEQLQHEIS---NKMEEFKILNDQNKALKSEVQK 716
Query: 1180 GSSREKTREVIDAAEVIETDLEETEREISPQENGPEE-VKPVGKMETDLKEIREEISQRE 1238
+ + D E +E ++E + ++ E E + V E +L IR E S
Sbjct: 717 LQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLT 776
Query: 1239 KVLAEFSAIREKEIDLKETGKRDIPIMEKVSGKMAVVEEM-EADL-KETGKENFRERGSE 1296
K + + A + ++ + ++ + GK+ VEE+ EA+L K KE + +
Sbjct: 777 KEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQ 836
Query: 1297 EICVTEEKVA--ELKQTGKTDISPRENELEETSTSRQTDTHLMQSGSNDFSAVPSLDIQN 1354
EI +E++ +L++ + I+ + EL+ ++
Sbjct: 837 EIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKE----------------------- 873
Query: 1355 ISSEVLSMMHTPVEEKRNSEKEVSSHFSHFKISSQTHESDKTEVQGIQSPDVPEQFSDIN 1414
E ++ M +EEK EK++++ + + +ES K VQ + ++ E S
Sbjct: 874 ---EQMNTMKAVLEEK---EKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQ 927
Query: 1415 LSK-SLPQEQKPLEIKPAPFVRSRFKRPKPNLARAALKRETTESEKYIYEKKSETKKMET 1473
+ + ++K E+K + + K + +L+ + + E +++ + E K
Sbjct: 928 FEELEIVLKEKENELKR---LEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLK--- 981
Query: 1474 IVMQENNEQTDTLPSQHDEASLMISREKDTLGHRNEEAVILPCT--QTERNLSPSNSCEP 1531
Q+N +Q + P + ++ REK+ G NE + Q ++N E
Sbjct: 982 ---QQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNERQQQVEA 1038
Query: 1532 KEESQSAPVQKNDSVVSVGTNN-----VNTFQQEMKESVIQTARQVRGRLQRPRPNIRKT 1586
E ++K VSV +N ++ F+++ KE + T+ ++ + +++
Sbjct: 1039 VELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHK--LKEA 1096
Query: 1587 GQRQIVDKGEA---KGIIKEGRTILPK------DETEKKVLTVSNSQIETEIEVPSSAVP 1637
+ + + E K ++ E IL K E K + V S + S
Sbjct: 1097 DEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSS 1156
Query: 1638 EHRMYENQSQVVLVENLHVNKTNETIRHENKPYVPSSAQMTRRKFQKAKPNLGRAHSKKE 1697
E + +S+ +ENL + + + E K + S +T + KA+ N + E
Sbjct: 1157 EQELERLRSENKDIENLRREREHLEMELE-KAEMERSTYVTEVRELKAQLNETLTKLRTE 1215
Query: 1698 EPVLEKVTTDQSKEGKPEDHL---LQKGASNTQLLLKEKAELLTSLEVSARKDCVGSKES 1754
+ +KV D K + + + + K A +T ++ E +++ E S ++ S
Sbjct: 1216 QNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVI--ENSDVSPETESSEKETMSVSLNQ 1273
Query: 1755 ALAKIDAELEEV 1766
+ ++ L+ V
Sbjct: 1274 TVTQLQQLLQAV 1285
Score = 37.0 bits (84), Expect = 0.26
Identities = 109/602 (18%), Positives = 244/602 (40%), Gaps = 70/602 (11%)
Query: 1092 EETEREIS--PQENG-LEEVKPLGEMQTDLKATGREISPREKTPEVIDATEEIDKDLEET 1148
E+ E EI+ QENG L + Q + K + R+ D +++ E+T
Sbjct: 413 EQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQ------DYARLVNELTEKT 466
Query: 1149 GRREISPEENGPEEV--KPVDEMETDLKTTGREGSSR--EKTREVIDAAEVIETDLEETE 1204
G+ + EEV K ++ T LK +E R E + E ++ +
Sbjct: 467 GKLQ-------QEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQ 519
Query: 1205 REISPQENGPEEVKPVGKMETDLKEIREEISQREKVLAEFSAIREKEIDLKETGKRDIP- 1263
+ +EN EV+ + TD ++++ QR L + +K ++ +E+ + +
Sbjct: 520 SKFVAKEN---EVQSLHSKLTDTLVSKQQLEQR---LMQLMESEQKRVNKEESLQMQVQD 573
Query: 1264 IMEKVSGKMAVVEEMEADLKETGKENFRERGSEEICVTEEKVAELKQTGKTDISPREN-- 1321
I+E+ A +++ + + + + E V EK ++KQT + S R+
Sbjct: 574 ILEQNEALKAQIQQFHSQI--AAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLT 631
Query: 1322 ELEETSTSRQTDTHLMQSGSNDFSAVPSLDIQNISSEVLSMMHTPVEEKRNS-------- 1373
EE Q L+++ A+ + Q ++ L M V K +
Sbjct: 632 SKEEELKDIQNMNFLLKAEVQKLQALANE--QAAAAHELEKMQQSVYVKDDKIRLLEEQL 689
Query: 1374 EKEVSSHFSHFKISSQTHESDKTEVQGIQSPDVPEQFSDI--NLSKSLPQEQKPL----E 1427
+ E+S+ FKI + +++ K+EVQ +Q+ + D+ + K + ++ + L E
Sbjct: 690 QHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEE 749
Query: 1428 IKPAPFVRSRFKRPKPNLARAALKRETTESEKYIYEKKSETKKMETIVMQENNEQTDTLP 1487
+ ++ K + N A++ E + K + + K+ K+ + + E+ +
Sbjct: 750 LLETGLIQVATKEEELN----AIRTENSSLTKEVQDLKA--KQNDQVSFASLVEELKKVI 803
Query: 1488 SQHDEASLMISR--EKDTLGHRNEEAVILPCTQTERNLSPSNSCEPKEESQ----SAPVQ 1541
+ D + E + L N+E + Q + L E++Q ++ VQ
Sbjct: 804 HEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQ 863
Query: 1542 KNDSVVSVGTNNVNTFQQEMKESVIQTA------RQVRGRLQRPRPNIRKTGQRQIVDKG 1595
+ +++ +NT + ++E A + ++ + + ++++ Q + +
Sbjct: 864 ELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEAS 923
Query: 1596 EAKGIIKEGRTILPKDETEKK----VLTVSNSQIETEIEVPSSAVPEHRMYENQSQVVLV 1651
A +E +L + E E K +L S + ++ ++ E++++++Q + +
Sbjct: 924 SASQ-FEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQ 982
Query: 1652 EN 1653
+N
Sbjct: 983 QN 984
>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sapiens]
Length = 1116
Score = 78.2 bits (191), Expect = 1e-13
Identities = 192/1039 (18%), Positives = 388/1039 (37%), Gaps = 193/1039 (18%)
Query: 400 RKNVKVKKVACEGVNNDPDESMSSRISDTERSQKDAQ---TVEEESLTLSREDAEQVALE 456
RK+V+VK+ N S + +KD T+ +E + +E+ + + +
Sbjct: 169 RKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMT 228
Query: 457 VDLNQKKRRRKK-------QDGANELGVNNLLE--NATVQAGPSKGEKHKNKCQAIRPEL 507
+ Q + R ++ QD ++ G + E Q ++ E+ + +R L
Sbjct: 229 IQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTL 288
Query: 508 KEGECSKEQMLSCTQNIDGIVGFASTEKVEKRTDPILSLSNQQDATSVATESSESSTSDL 567
+E E E A E ++K +L + + ++ ATE T L
Sbjct: 289 EEMELRIETQKQTLN--------ARDESIKK----LLEMLQSKGLSAKATEEDHERTRRL 336
Query: 568 PSFEVGIRALCEVNNAEGSCIEERNVDLKNNSLEIDQTENVKPMLRGRFQRPKPNLSRAG 627
E+ + L + ++Q E MLR R N +
Sbjct: 337 AEAEMHVHHLESL---------------------LEQKEKENSMLREEMHRRFENAPDSA 375
Query: 628 KKSVLSQGKTESESKNSHSKTSVEKNHVEKDKMNTLDILRMETTERENPEAETVSVLGEK 687
K L +SK S + + E + + L E E E
Sbjct: 376 KTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEE------------- 422
Query: 688 NCLQEGSQLKALRPVQVRGRLQKPKPNAGKAAERKEILISQEEIGANVEKNENESCADRD 747
+K + + + K K + KE L S+E ++K + +
Sbjct: 423 --------MKQMEVYRSHSKFMK-----NKVEQLKEELSSKEAQWEELKKKA--AGLQAE 467
Query: 748 TPQHMEDQSRKDFEEEDVILQPEKNDSFQNVQPDEPK---VLNECLSVQENNKANKLNQV 804
Q ++ SRKD E ++ K ++ N D + VL E L+ +E A +V
Sbjct: 468 IGQVKQELSRKDTE---LLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEV 524
Query: 805 PILRTRFQKPKPNIGRGTGRREISSKEEVLEKILVSGEMAAALRETV-RLDTSPKEMVPA 863
LR R ++ + + + T + + ++E+ G A + + LD +++
Sbjct: 525 DALRLRLEEKETMLNKKTKQIQDMAEEK--------GTQAGEIHDLKDMLDVKERKVNVL 576
Query: 864 EINTKEMQSDLKETGRRAISPREKILDVIDDTIEMETGLKAMGREICLREKTPEVIDATE 923
+ + +Q L++ ++ S +E++ + DT +T L + + +E+T E + E
Sbjct: 577 QKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLK--E 634
Query: 924 EIDKDLEEAGRREISPQKNGPEEVKPLGEVETDLKATGNESSPREKTPEVTDATEEIDKN 983
+ D+D REK E+ + +++ K+
Sbjct: 635 QRDRD-------------------------------------EREKQEEIDNYKKDL-KD 656
Query: 984 LEETGRRKISPRENGPEEVKPVDEMETDLNATGRESSPREKTPEVIDATEEIDLEETERE 1043
L+E K+S + E K ++ +A+ SS +K + T EI LE+ + E
Sbjct: 657 LKE----KVSLLQGDLSE-KEASLLDLKEHASSLASSGLKKDSRL--KTLEIALEQKKEE 709
Query: 1044 VSPQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEVIDAIEEIEIDL----EETEREIS 1099
+ME+ LK + +PE+ D I+ +E ++ +E+ + +
Sbjct: 710 CL-------------KMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQA 756
Query: 1100 PQENGLEEVKPLGEMQTD----LKATGREISPREKTPEVIDATEEIDKD-----LEETGR 1150
+ LE +K + + D + R++ + K + E+++K LEE R
Sbjct: 757 EVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARR 816
Query: 1151 REISPEENG---PEEVKPVDEMETDLKTTGREGSSREKTREVIDAAEVIETDLEETEREI 1207
RE + ++ + ++ D+ +L+ RE RE++ A E E+ E+++
Sbjct: 817 REDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQE--ESARTNAEKQV 874
Query: 1208 SPQENGPEEVK-PVGKMETDLKEIREEISQREKVLAEFSAIREKEIDLKETGKRDIPIME 1266
E+VK + M+ L ++ ++++E L A R K ++ ++E
Sbjct: 875 EELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLE---------EVLE 925
Query: 1267 -KVSGKMAVVEEMEADLKETGKENFRERGSEEICVTEEKVAELKQTGKTDISPRENELEE 1325
K +A + E +A++ + +++ EE+ + + L Q K R + +
Sbjct: 926 MKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMAD 985
Query: 1326 TSTSRQTDTHLMQSGSNDFSAVPSLDIQNISSEVLSMMHTPVEEKRNSEKEVSSHFSHFK 1385
D H S SN + PS D + P+ E + ++ + H
Sbjct: 986 ----NYEDDHFKSSHSNQTNHKPSPD----------QIIQPLLELDQNRSKLKLYIGH-- 1029
Query: 1386 ISSQTHESDKTEVQGIQSP 1404
+++ H+ D ++G+ P
Sbjct: 1030 LTTLCHDRDPLILRGLTPP 1048
Score = 39.3 bits (90), Expect = 0.052
Identities = 99/509 (19%), Positives = 200/509 (39%), Gaps = 60/509 (11%)
Query: 1187 REVIDAAEVIETDLEETEREISPQENGPEEV-KPVGKMETDLKEIREEISQREKVLAEFS 1245
+EV+ +++ D+E E ++S N + P K E L+ ++E S+ ++
Sbjct: 159 KEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALR--KDEASKITIWKEQYR 216
Query: 1246 AIREKEIDLKETGK---------RDIPIMEKVSGKMAVVEEMEADLKETGKENFR----- 1291
++E+ ++ T + RD+ + + E A+L E ENF+
Sbjct: 217 VVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTE---ENFQRLHAE 273
Query: 1292 -ERGSEEICVTEEKVAELK---QTGKTDISPRENELEETSTSRQTDTHLMQSGSNDFSAV 1347
ER ++E+ + + + E++ +T K ++ R+ +++ Q+ ++ D
Sbjct: 274 HERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERT 333
Query: 1348 PSLDIQNISSEVLSMMHTPVEEKRNS--EKEVSSHFSHFKISSQTH------ESDKTEVQ 1399
L + L + +EK NS +E+ F + S++T E +++
Sbjct: 334 RRLAEAEMHVHHLESL-LEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKIS 392
Query: 1400 GIQSP--DVPEQFSDINLSKSLPQEQKPLEIKPAPFVRSRFKRPKPNLARAALKRETTES 1457
++ D+ E+ + + +L E++ E+K RS K K + + LK E +
Sbjct: 393 SMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQ--LKEELSSK 450
Query: 1458 EKYIYEKKSETKKMETIVMQENNE-------------QTDTLPSQHDEASLMISREKDTL 1504
E E K + ++ + Q E + +TL +Q ++ I K++L
Sbjct: 451 EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESL 510
Query: 1505 GHRNEEAVILPCTQTERNLSPSNSCEPKEESQSAPVQKNDSVVSVGTNNVNTFQQEMKES 1564
+ + A IL QTE + E + Q D GT ++K+
Sbjct: 511 TAKEQRAAIL---QTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEI--HDLKDM 565
Query: 1565 VIQTARQVRGRLQRPRPNIRKTGQRQIVDKGEAKGIIKEGRTILPKDETEKKVLTVSNSQ 1624
+ R+V LQ+ N+ Q Q+ DK + +KE L D T + +
Sbjct: 566 LDVKERKV-NVLQKKIENL----QEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEE 620
Query: 1625 IETEIEVPSSAVPEHRMYENQSQVVLVEN 1653
E E + E R + + + ++N
Sbjct: 621 ALAEKERTIERLKEQRDRDEREKQEEIDN 649
Score = 32.0 bits (71), Expect = 8.3
Identities = 143/786 (18%), Positives = 290/786 (36%), Gaps = 113/786 (14%)
Query: 1461 IYEKKSETKKMETIVMQENNEQTDTLPSQHD--------------EASLMISREKDTLGH 1506
++++ S ++ E V + E L ++H+ E L I +K TL
Sbjct: 245 LFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNA 304
Query: 1507 RNEEAVILPCTQTERNLSPSNSCEPKEESQSAPVQKNDSVVSVGTNNVNTFQQEMKESVI 1566
R+E L E S S + EE + ++ + V Q+E + S++
Sbjct: 305 RDESIKKL----LEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML 360
Query: 1567 QTARQVRGRLQRPRPNIRKTGQRQIVDKGEAKGIIKEGRTILPKDETEKKVLTVSNSQIE 1626
R+ R P+ KT Q V + + I R + +D E+ + SN +
Sbjct: 361 ---REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGL--RDLEEEIQMLKSNGALS 415
Query: 1627 TEIEVPSSAVPEHRMYENQSQVVL--VENLHVNKTNETIRHENKPYVPSSAQMTRRKFQK 1684
TE + + +Y + S+ + VE L +++ + E + A + + +
Sbjct: 416 TEER--EEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEE---LKKKAAGLQAEIGQ 470
Query: 1685 AKPNLGRAHSKKEEPVLEKVT-----TDQSKEGKPEDHLLQKGASNTQLLLKEKAELLTS 1739
K L S+K+ +L T T+Q + K +L++ L KE+ +
Sbjct: 471 VKQEL----SRKDTELLALQTKLETLTNQFSDSKQHIEVLKES-----LTAKEQRAAILQ 521
Query: 1740 LEVSARKDCVGSKESALAKIDAELEEVGPSRRVGEETVGDNSPSSVVEEQYLNKLTSCPQ 1799
EV A + + KE+ L K +++++ + + D V+E+ +N L +
Sbjct: 522 TEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIE 581
Query: 1800 PLNETSYSK-------------IALDGKTTISSTSEYERNRGER-RSHKKFKPNVTRGRG 1845
L E K + D T ++ + E E+ R+ ++ K R
Sbjct: 582 NLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDER 641
Query: 1846 SKRVRGKTSKKEPRASKAMLVTLRASQEEDDDADDFESDYEEESYHLAPEEVNKAPVFVP 1905
K+ KK+ + K + L+ E + + D +E + LA + K
Sbjct: 642 EKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEAS---LLDLKEHASSLASSGLKK------ 692
Query: 1906 VGLRSPEPVSAQIEETMEELEITVNVPDVGCIAVVEHELPNTDVTTEEMKQEENLSVPFE 1965
+ ++ LEI + C+ +E +L E + +S +
Sbjct: 693 -------------DSRLKTLEIALEQKKEECLK-MESQLKKAHEAALEARASPEMSDRIQ 738
Query: 1966 MTTSE--HIQDEPGTNDGSTEAAITLLTMGDLVLQSEISSEQGDVGVCIIP-HVHSKDKS 2022
E +DE + + +L E+ +E+ D I KD++
Sbjct: 739 HLEREITRYKDESSKAQAEVDRLLEIL--------KEVENEKNDKDKKIAELERQVKDQN 790
Query: 2023 HIPSSLDNVNHKIVHECQELSSPVITTSPASFEENKIVLEEQSSREEISLMEK---VKEN 2079
+ N+ HK + ++ S + E+N L + S + + SL +K ++E
Sbjct: 791 ---KKVANLKHK--EQVEKKKSAQMLEEARRREDN---LNDSSQQLQDSLRKKDDRIEEL 842
Query: 2080 ATPTRNTISKVTSNLRIRSRLAKPKPNLEKTLGTNRL---DDYQEVSSLCVTKGAEMETQ 2136
R ++ + ++ + N EK + + QE+ S+ + ++
Sbjct: 843 EEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSL 902
Query: 2137 RETEKNASKATELENKNLGPVTTAENKDQSKLACVHGIKGTSISSEVNLTERNENQEESS 2196
E E + + K+L V E K ++ LA + + + + L E + +++++
Sbjct: 903 AEKETHLTNLRAERRKHLEEV--LEMKQEALLAAI-----SEKDANIALLELSSSKKKTQ 955
Query: 2197 QEVHML 2202
+EV L
Sbjct: 956 EEVAAL 961
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 77.8 bits (190), Expect = 1e-13
Identities = 189/993 (19%), Positives = 370/993 (37%), Gaps = 148/993 (14%)
Query: 371 LQKVLAEEEKRKQK--------SVKNHSLKEKKSTKPRKNVKVKKVA-------CEGVNN 415
L++ L EEE +QK K L+E++ +N K+ K E N
Sbjct: 948 LEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTN 1007
Query: 416 DPDESMSSRISDTERSQKDAQTVEEESLTLSREDAEQVALEVDLNQKKRRRKKQDGANEL 475
+E S+ +++ +A + E L RE+ ++ LE K RRK + + +L
Sbjct: 1008 LTEEEEKSKSLAKLKNKHEAMITDLEE-RLRREEKQRQELE------KTRRKLEGDSTDL 1060
Query: 476 GVNNLLENATVQAGPSKGEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGIVGF----- 530
A + + K + + QA ++E K L + ++ +
Sbjct: 1061 SDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDL 1120
Query: 531 ----ASTEKVEKRTDPI--------LSLSNQQDATSVATESSESSTSDLPSFEVGIRALC 578
AS K EK+ + L + D+T+ E ++ + +
Sbjct: 1121 ESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEA 1180
Query: 579 EVNNAEGSCIEERNVDLKNNSLE-IDQTENVKPMLRGRFQRPKPNLSR-AGKKSVLSQGK 636
+ + A+ + +++ E ++QT+ VK L Q + A + VL QGK
Sbjct: 1181 KTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGK 1240
Query: 637 TESESKNSHSKTSVEKNHVEKDKMNTLDILRMETTERENPEAETVSVLGEKNCLQEGSQL 696
+SE K + +++ V K N + +R E ++ +
Sbjct: 1241 GDSEHKRKKVEAQLQELQV---KFNEGERVRTELADKVTKLQVELD-------------- 1283
Query: 697 KALRPVQVRGRLQKPKPNAGKAAERKEILISQEEIGANVEKNENESCADRDTPQHMEDQS 756
V G L + + K + L SQ + DT + +++++
Sbjct: 1284 ------NVTGLLSQSDSKSSKLTKDFSALESQLQ----------------DTQELLQEEN 1321
Query: 757 RKDFEEEDVILQPEKNDSFQNVQPDEPKVLNECLSVQENNKANKLNQVPILRTRFQKPKP 816
R+ + Q E DE E L +E K N Q+ L + K
Sbjct: 1322 RQKLSLSTKLKQVE----------DEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKK 1371
Query: 817 NIGRGTGRREISSKEEVLEKILVSGEMAAALRETVRLDTSPKEMVPAEINTKEMQSDLKE 876
+ G E + EEV K+ ++ L +E V A L++
Sbjct: 1372 KMEDSVGCLETA--EEVKRKLQ---------KDLEGLSQRHEEKVAA-------YDKLEK 1413
Query: 877 TGRRAISPREKILDVIDDTIEMETGLKAMGREICLREKTPEVIDATEEIDKDLEEAGRRE 936
T R + +L +D + L+ ++ + I A ++D EA RE
Sbjct: 1414 TKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEARE 1473
Query: 937 ISPQKNG-PEEVKPLGEVETDLKATGNESSPREKTPEVTDATEEIDKNLEETGRRKISPR 995
+ ++ E + +L+ + R + ++ + +++ K++ E + K +
Sbjct: 1474 KETKALSLARALEEAMEQKAELERLNKQF--RTEMEDLMSSKDDVGKSVHELEKSKRALE 1531
Query: 996 ENGPEEVKPVDEMETDLNATGRESSPREKTPEVIDATEEIDLEETEREVSPQENGLEEVK 1055
+ E ++E+E +L AT E + + A E DL+ R+ +E + V+
Sbjct: 1532 QQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQ--GRDEQSEEKKKQLVR 1589
Query: 1056 PLGEMETDLKATGRDSFPRGKTPEVIDAIEEIEIDLEETEREI-SPQENGLEEVKPLGEM 1114
+ EME +L+ R + + A +++E+DL++ E I S +N E +K L ++
Sbjct: 1590 QVREMEAELED------ERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKL 1643
Query: 1115 QTDLKATGREI-SPREKTPEVIDATEEIDKDLE--ETGRREISPEENGPEEVKPVDEMET 1171
Q +K RE+ R E++ +E +K L+ E ++ E E K + E
Sbjct: 1644 QAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQER 1703
Query: 1172 DLKTTGREGSSREKTREVIDAAEVIETDLEETEREISPQENGPEEVK--------PVGKM 1223
D + +S K ++ +E + + E E+ ++ E + + ++
Sbjct: 1704 D-ELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQI 1762
Query: 1224 ETDLKEIREEISQREKVLAEFS--------AIREKEIDLKETGKRDIPIMEKVSGKMAVV 1275
TDL R + E + ++E E +K K I +E A +
Sbjct: 1763 NTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALE------AKI 1816
Query: 1276 EEMEADLKETGKENFRERGSEEICVTEEKVAEL 1308
++E L KE R+ +++ TE+K+ ++
Sbjct: 1817 AQLEEQLDNETKE--RQAACKQVRRTEKKLKDV 1847
Score = 49.3 bits (116), Expect = 5e-05
Identities = 226/1215 (18%), Positives = 450/1215 (37%), Gaps = 186/1215 (15%)
Query: 946 EVKPLGEV---ETDLKATGNES-SPREKTPEVTDATEEIDKNLEETGRRKISPRENGPEE 1001
+VKPL +V E ++ A E REK + E++ + K+ +E E
Sbjct: 833 KVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAE 892
Query: 1002 VKPVDEMETDLNATGRESSPREKTPEVIDATEEIDLEETER------EVSPQENGLEEVK 1055
+ E E +L A R ++ +++ E+ E EE ER E + ++E++
Sbjct: 893 TELCAEAE-ELRA--RLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELE 949
Query: 1056 PLGEMETDLKATGRDSFPRGKTPEVIDAIEEIEIDLEETEREISPQENGLEEVKPLGEMQ 1115
++E + A + + T + +EE +I LE+ +++ ++ LE+ + E
Sbjct: 950 E--QLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLED--RIAEFT 1005
Query: 1116 TDLKATGREISPREKTPEVIDATEEIDKDLEETGRREISPEENGPEEVKPVDEMETDLKT 1175
T+L E + ++ + E + DLEE RRE + + + ++ TDL
Sbjct: 1006 TNLT---EEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSD 1062
Query: 1176 TGREGSSR---------EKTREVIDAAEVIETD----------LEETEREISP-QENGPE 1215
E ++ +K E+ A +E + + E E +IS QE+
Sbjct: 1063 QIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLES 1122
Query: 1216 EVKPVGKMETDLKEIREEISQREKVLAEFSAIREKEIDLKETGKRDIPIMEKVSGKMAVV 1275
E K E +++ EE+ + L + + +L+ ++++ I++K
Sbjct: 1123 ERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTL------ 1176
Query: 1276 EEMEADLKETGKENFRERGSEEICVTEEKVAELKQTG--KTDISPRENELEETSTSRQTD 1333
E EA E + R++ S+ + EE +L+QT K ++ + LE +
Sbjct: 1177 -EEEAKTHEAQIQEMRQKHSQAV---EELAEQLEQTKRVKANLEKAKQTLENERGELANE 1232
Query: 1334 THLMQSGSNDFSAVPSLDIQNISSEVLSMMHTPVEEKRNSEKEVSSHFSHFKISSQTHES 1393
++ G D E KR K+V + ++ E
Sbjct: 1233 VKVLLQGKGD-----------------------SEHKR---KKVEAQLQELQVKFNEGER 1266
Query: 1394 DKTEVQGIQSPDVPEQFSDINLSKSLPQEQKPLEIKPAPFVRSRFKRPKPNLARAALKRE 1453
+TE L+ + + Q L+ +S K K +AL+ +
Sbjct: 1267 VRTE-----------------LADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQ 1309
Query: 1454 TTESEKYIYEKKSETKKMETIVMQENNEQTDTLPSQHDEASLMISREKDTLGHRNEEAVI 1513
++++ + E+ + + T + Q +E+ +E + EK + A
Sbjct: 1310 LQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVA-- 1367
Query: 1514 LPCTQTERNLSPSNSCEPKEESQSAPVQKNDSVVSVGTNNVNTFQQEMKESVIQTARQVR 1573
++ + S C E +QK+ +S + E K + + +
Sbjct: 1368 ----DMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQ--------RHEEKVAAYDKLEKTK 1415
Query: 1574 GRLQRPRPN--IRKTGQRQIVDKGEAK-----GIIKEGRTILPKDETEKKVLTVSNSQIE 1626
RLQ+ + + QRQ E K ++ E +TI K E+ + E
Sbjct: 1416 TRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKE 1475
Query: 1627 TEIEVPSSAVPEHRMYENQSQVVLVENLHVNKTNETIRHENKPYVPSSAQMTRRKFQKAK 1686
T+ + A+ E + + + + N+ R E + + S K
Sbjct: 1476 TKALSLARALEE----------AMEQKAELERLNKQFRTEMEDLMSS------------K 1513
Query: 1687 PNLGRAHSKKEEPVLEKVTTDQSKEGKPEDHLLQKGASNTQLLLKEKAELLTSLEVSARK 1746
++G++ + E+ ++ Q +E K + L+ T+ L +++ +
Sbjct: 1514 DDVGKSVHELEKS--KRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFER 1571
Query: 1747 DCVGSKESALAKIDAELEEVGPSRRVGEETVGDNSPSSVVEEQYLNKLTSCPQPLNETSY 1806
D G E + K + +V R + E + S+ +
Sbjct: 1572 DLQGRDEQSEEKKKQLVRQV---REMEAELEDERKQRSMA----------------VAAR 1612
Query: 1807 SKIALDGKTTISSTSEYERNRGE-----RRSHKKFKP---NVTRGRGSKRVRGKTSKKEP 1858
K+ +D K + +NR E R+ + K + R S+ +K+
Sbjct: 1613 KKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENE 1672
Query: 1859 RASKAMLVTLRASQEEDDDADDFESDYEEESYHLAPEEVNKAPVFVPVGLRSPEPVSAQI 1918
+ K+M + QEE A+ + ++E LA E N + + L + A+I
Sbjct: 1673 KKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGA-LALEEKRRLEARI 1731
Query: 1919 EETMEELE----ITVNVPDVGCIAVVEHELPNTDVTTE--EMKQEENLSVPFEMTTSE-- 1970
+ EELE T + D A ++ + NTD+ E ++ EN E E
Sbjct: 1732 AQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELK 1791
Query: 1971 -HIQDEPGTNDGSTEAAITLLTMGDLVLQSEISSEQGD-VGVCIIPHVHSKDKSHIPSSL 2028
+Q+ GT +A+IT L L+ ++ +E + C K + +
Sbjct: 1792 VKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQV 1851
Query: 2029 DNV--NHKIVHECQELSSPVITTSPASFEENKIVLEEQSSREEIS--LMEKVKENATPTR 2084
D+ N + + + +S + EE EE++ R S +++ E+AT T
Sbjct: 1852 DDERRNAEQYKDQADKASTRLKQLKRQLEE----AEEEAQRANASRRKLQRELEDATETA 1907
Query: 2085 NTISKVTSNLRIRSR 2099
+ +++ S+L+ + R
Sbjct: 1908 DAMNREVSSLKNKLR 1922
Score = 36.2 bits (82), Expect = 0.44
Identities = 121/627 (19%), Positives = 233/627 (37%), Gaps = 105/627 (16%)
Query: 1571 QVRGRLQRPRPNIRKTGQRQIVDKGEAKGIIKEGRTILPKDETEKKVLTVSNSQIETEIE 1630
+V+ LQ R + + + K K + E R L + ET + L Q++ +++
Sbjct: 833 KVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENR--LTEMETLQSQLMAEKLQLQEQLQ 890
Query: 1631 VPS---SAVPEHRMYENQSQVVLVENLHVNKTNETIRHENKPYVPSSAQMTRRKFQKAKP 1687
+ + E R + L E H + E ++ + + ++ Q+ +
Sbjct: 891 AETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEE 950
Query: 1688 NLGRAHSKKEEPVLEKVTTDQSKEGKPEDHLLQ-----KGASNTQLLLKEKAELLTSLEV 1742
L S +++ LEKVTT+ + E+ ++ K A +LL AE T+L
Sbjct: 951 QLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTE 1010
Query: 1743 SARKD------------CVGSKESALAKIDAELEEVGPSRRVGEETVGDNSPSSVVEEQY 1790
K + E L + + + +E+ +RR E D S +
Sbjct: 1011 EEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQ 1070
Query: 1791 LNKL------------TSCPQPLNETSYSKIALDG-KTTISSTSEYERNRGERRSHKKFK 1837
+ +L + + E + +AL + S SE + + R+ +
Sbjct: 1071 IAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKA 1130
Query: 1838 PNVTRGRGSKRVRGKTSKKEPRASKAMLVTLRASQEE---------DDDADDFESDYEE- 1887
R G + KT ++ S A LR+ +E+ +++A E+ +E
Sbjct: 1131 EKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEM 1190
Query: 1888 -ESYHLAPEEVNKAPVFVPVGLRSPEPVSAQIEETMEEL---------EITVNVPDVGCI 1937
+ + A EE+ + L + V A +E+ + L E+ V + G
Sbjct: 1191 RQKHSQAVEELAEQ-------LEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKG-- 1241
Query: 1938 AVVEHELPNTDVTTEEMKQEENLSVPFEMTTSEHIQDEPGTNDGSTEAAITLLTMGDLVL 1997
EH+ + +E++ + N E ++ E D T+ + L + L+
Sbjct: 1242 -DSEHKRKKVEAQLQELQVKFN--------EGERVRTE--LADKVTKLQVELDNVTGLLS 1290
Query: 1998 QSEISSEQGDVGVCIIPHVHSKDKSHIPSSLDNVNHKIVHECQELSSPVITTSPASFEEN 2057
QS+ S + +KD S + S L + + E ++ S ++T E+
Sbjct: 1291 QSDSKSSK-----------LTKDFSALESQLQDTQELLQEENRQKLS--LSTKLKQVEDE 1337
Query: 2058 KIVLEEQSSREEISLMEKVKENATPTRNTISKVTSNLRIRSRLAKPKPNLEKTLGTNRLD 2117
K EQ EE + K+ AT + +++A K +E ++G L+
Sbjct: 1338 KNSFREQLEEEEEAKHNLEKQIAT--------------LHAQVADMKKKMEDSVGC--LE 1381
Query: 2118 DYQEVSSLCVTKGAEMETQRETEKNAS 2144
+EV + K E +QR EK A+
Sbjct: 1382 TAEEVKRK-LQKDLEGLSQRHEEKVAA 1407
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 76.6 bits (187), Expect = 3e-13
Identities = 386/2159 (17%), Positives = 803/2159 (37%), Gaps = 304/2159 (14%)
Query: 73 EKTGGDNDVEESSRSSSTVSQRRKRISSTSSLVKSSVSVPSESHPLSTINQEAPQPTATS 132
E TG D + + SS ++ + + S +S+ L + Q+ + +
Sbjct: 616 EDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAV 675
Query: 133 TKEKQPCSDRYRIYKAQKLREMLKEELRKEKKQWKNKYAINESQRPPDRSKMTMRDFIYY 192
Q D K+Q +L+ EL K Q + ++E + + +F
Sbjct: 676 PDIGQCHQDELERLKSQ----ILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKN 731
Query: 193 LPDNNPMTSSLEQEK-----KTEKPSTPVQTREQEGKSTPNAEDNEMEEETDDGPLLVPR 247
+N+ ++L +E+ + ++ S + R Q + N + E + D
Sbjct: 732 ADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDY------E 785
Query: 248 VKVAEDGSIILDEESLTVEVLRTKGPCVVEENDPIFERGSTTTYSSFRKNYYSKPWSNKE 307
+ A D + SL++E V +N+ + + S+ ++ S+ NKE
Sbjct: 786 SQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQ-LQNKE 844
Query: 308 TDMFFLA--ISMVGTDFSMIGQLFPHRA-RIEIKNKFKREEKTNGWRIDKAFQEKRPFDF 364
+++ A + + + + Q + I ++ E+K + + + +EK
Sbjct: 845 SEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVT 904
Query: 365 DFFAHLLQKVLAEEEKRKQKSVKNHSLKEKKSTKPR------KNVKVKKVACEGVNNDPD 418
+ + +K++ E++ V+ +LKE+ + R + V+ G+ + D
Sbjct: 905 EISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYD 964
Query: 419 ESMSSRISDTERSQKDAQTVEEESLTLSREDAEQVALEVDLNQKKRRRK------KQDGA 472
E + E Q + +++E+ R+ + +L Q+ R + K +
Sbjct: 965 EMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESK 1024
Query: 473 NELGVNNLLENATVQAGPSKGEKHK---NKCQAIRPELKEGECSKEQMLSCTQNIDGIVG 529
E+ ++ + +K K +KCQ I LK+ KE L
Sbjct: 1025 KEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVEL----------- 1073
Query: 530 FASTEKVEKRTDPILSLSNQ-QDATSVATESSESSTSDLPSFEVGIRALCEVNNAEGSCI 588
+ + K + L+ Q Q ++ + T+ + + I N A +
Sbjct: 1074 ----QHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISE----NQAIIQKL 1125
Query: 589 EERNVDLKNNSLE--IDQTENVKPMLRGRFQRPKPNLSRAGKKSVLSQGKTESESKNSHS 646
N D + + +T + P G + KP L K L + K + + K +
Sbjct: 1126 ITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEE--KILALEKEKEQLQKKLQEA 1183
Query: 647 KTS---VEKNHVEKDKMNTLDILRMETTERENPEAETVSVLGEKNCLQE--GSQLKALRP 701
TS + K EK++ LR E ++++ E++ E G QL+ L+
Sbjct: 1184 LTSRKAILKKAQEKERH-----LREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQ- 1237
Query: 702 VQVRGRLQKPKPNAGKAAERKEILISQEEIGANVEKNENESCADR----DTPQHMEDQSR 757
+QVR + P+ + +E + E++ + + D P H ED S
Sbjct: 1238 IQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASA 1297
Query: 758 --------------KDFEEEDVILQPEKNDSFQNVQPDEPKVLNECLSVQENNKANKLNQ 803
K+ E E V L+ + + + + +V L Q N + ++
Sbjct: 1298 LQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQ--LQEQINKQGLEIES 1355
Query: 804 VPI-----------LRTRFQKPKPNIGRGTGRREISSKEEVLEKILVSGEMAAALRETVR 852
+ L+ + + + I RE+ K + L+K++ E +
Sbjct: 1356 LKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSG-- 1413
Query: 853 LDTSPKEMVPAEINTKEM-QSDLKETGRRAISPREKILDVIDDTIEMETGLKAMGREICL 911
S KE +I T+ + Q DL + + + K E + +K + E+C
Sbjct: 1414 -QLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAK---------EHDERIKQLQVELCE 1463
Query: 912 REKTPEVID----ATEEIDKDLEEA--GRREISPQKNGPEE------------VKPLGEV 953
++ PE I A ++I + L+ A R+E + +E K L +V
Sbjct: 1464 MKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADV 1523
Query: 954 ETDLKATGNESSPREKTPEVTDATEEIDKNLEETGRRKISPRE--NGPEEVKPVDEMETD 1011
E+ + A E + EE DK + E R + + + E +K E T+
Sbjct: 1524 ESQVSAQNKEKDT--VLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTE 1581
Query: 1012 LNATGRESSPREKTPEVIDATE-EIDLEETEREVSPQENGLEEVKPLGEMETDLKATGRD 1070
+ K+ ++ ++TE + +E ++E E V E + R
Sbjct: 1582 DKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQ 1641
Query: 1071 SFPRGKTPEVIDAIEEIEIDLEETEREISPQENGLEEVK------------PLGEMQTDL 1118
+ E+ + E + +ETE+++ E +EE+K + E++ +
Sbjct: 1642 -----EKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEEN 1696
Query: 1119 KATGREISP-----REKTPEVIDATEEIDKDLE------ETGRRE----ISPEENGPEEV 1163
E+ P +E ++ + + ++LE ET ++ +S +++ EEV
Sbjct: 1697 DRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEV 1756
Query: 1164 KPVDEMETDLKTTGREGSSREKTREVIDAAEVIETDLEETEREISPQENGPEEVKP---- 1219
+ +++ ++ + ++ E T + + V E + E Q++ +P
Sbjct: 1757 Q---DLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSE 1813
Query: 1220 -VGKMETDLKEIREEISQREKV---LAEFSAIREKEIDLKETGKRDIPIMEKVSGK---- 1271
V ++ + ++ S +++ L + ++E+ L+E +++ + + +
Sbjct: 1814 SVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTL 1873
Query: 1272 MAVVEEMEADLK----ETGKENFRERGSEEICVTEEKVAELKQTGKTDISPR-ENELEET 1326
++ + + +LK E K N + +E K+ E + K D+ R N+L E
Sbjct: 1874 LSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAEL 1933
Query: 1327 STS------RQTDTHLMQSGSNDFSAVPSLDIQNISSEVLSMMHTPVEEKRNSEKEVSSH 1380
+ S TD + N+ +++ SE+ V+EK E E+
Sbjct: 1934 NGSIGNYCQDVTDAQI----KNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKE 1989
Query: 1381 FSHFKISSQTHESDKTEVQGIQSPDVPEQFSDINLSKSLPQEQKPLE-----IKPAPFVR 1435
+ +Q +K+ + +Q +Q L K + Q+ + +K FV+
Sbjct: 1990 YLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQ 2049
Query: 1436 SRFKR----PKPNLARAALKRETTESEKYIYE-KKSETKKMETIVMQENNEQTDTLPSQH 1490
+ ++ K NLA+A R+ ++E ++ +T+ V+ +N + L S
Sbjct: 2050 TESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNK 2109
Query: 1491 DEASLMISREKDTLGHRNEEAVILPCTQTERNLSPSNSCEPKEES---QSAPVQKNDSVV 1547
+ + ++ + L R E+A E++L + + K ++ + +++ +
Sbjct: 2110 ESVKSQMKQKDEDLERRLEQA-------EEKHLKEKKNMQEKLDALRREKVHLEETIGEI 2162
Query: 1548 SVGTNNVNTFQQEMKESVIQTARQV------RGRLQRPRPNI---RKTGQRQIVDKGEAK 1598
V N + Q+++E++ T Q+ LQ R + K +R+ D ++K
Sbjct: 2163 QVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSK 2222
Query: 1599 G---IIKEGRTILPKDETEKKVLTVSNSQIETEIEVPSSAVPEHRMYENQSQVVLVENLH 1655
+KE + KD+ + + + +I S + +++E+++Q E
Sbjct: 2223 EEEIRLKEDNCSVLKDQLRQMSIHMEELKINI-----SRLEHDKQIWESKAQ---TEVQL 2274
Query: 1656 VNKTNETIRHENKPYVPSSAQMTRRKFQKAKPNLGRAHSKKEEPVLEKVTTDQSKEGKPE 1715
K +T++ ENK + S + TR + ++ L + S+ + L+ TD
Sbjct: 2275 QQKVCDTLQGENKELL-SQLEETRHLYHSSQNELAKLESELKS--LKDQLTD-------- 2323
Query: 1716 DHLLQKGASNTQLLLKEKAELLTSLEVSARKDCVGSKESALAKIDAELEEVGPSRRVGEE 1775
SN+ KE+ L + D SK S E++ + E
Sbjct: 2324 -------LSNSLEKCKEQKGNLEGIIRQQEADIQNSKFS--------YEQLETDLQASRE 2368
Query: 1776 TVGDNSPSSVVEEQYLNKLTSCPQPLNETSYSKIALDGKTTISS-----TSEYERNRGER 1830
++EQ + L S + + + +++ I + E E N
Sbjct: 2369 LTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLE 2428
Query: 1831 RSHKKFKPNVTRGRGSKRVRGKTSKKEPRASKAMLVT-LRASQEEDDDADDFESDYEE-E 1888
+KK + + KT KKE KA L + +++ +D D DY++ E
Sbjct: 2429 EENKKAVDKTNQLMETL----KTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLE 2484
Query: 1889 SYHL------------APEEVNKAPVFVPVGLRS--------PEPVSAQIEETMEELEIT 1928
HL A E NK + GLRS + A++ + E+L
Sbjct: 2485 ERHLSIILEKDQLIQEAAAENNKLKEEIR-GLRSHMDDLNSENAKLDAELIQYREDLNQV 2543
Query: 1929 VNVPDVGCIAVVEHEL-PNTDVTTEEMKQEENLSVPFEMT-----TSEHIQDEPGTNDGS 1982
+ + D ++E +L N ++ + K EE L E + +Q+E D S
Sbjct: 2544 ITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEE--KQDLS 2601
Query: 1983 TEAAITLLTMGDLVLQSEISSEQGDVGVCIIPHVHSKDKSHIPSSLDNVNHKIVHECQE 2041
E +++ L Q E+G +G+ +++ H S+L + + K + E +E
Sbjct: 2602 KEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEE 2660
Score = 73.6 bits (179), Expect = 2e-12
Identities = 371/1996 (18%), Positives = 773/1996 (38%), Gaps = 338/1996 (16%)
Query: 378 EEKRKQKSVKNHSLKEKKSTKPRKNVKVKKVACEGVNNDPDESMSSRISDTERSQKDAQT 437
EE+ + + +K H L+EK+ ++ + E E M + ++ Q+ +
Sbjct: 141 EEEMEIEKIK-HKLQEKEELISTLQAQLTQAQAEQPAQSSTE-MEEFVMMKQQLQEKEEF 198
Query: 438 VEEESLTLSREDAEQVALEVDLNQKKRRRKKQDGANELGVNNLLENATVQAGPSKGEKHK 497
+ LS+ AEQ A +V + +K R + Q +E + L+ A V+ + +
Sbjct: 199 ISTLQAQLSQTQAEQAAQQV-VREKDARFETQVRLHEDELLQLVTQADVET------EMQ 251
Query: 498 NKCQAIRPELKEGECSKEQMLSCTQNIDGIVGFASTEKVEKRTDPILSLSNQQDATSVAT 557
K + ++ +L+E E E ++ Q +D + QQ+ T+ A
Sbjct: 252 QKLRVLQRKLEEHE---ESLVGRAQVVDLL---------------------QQELTA-AE 286
Query: 558 ESSESSTSDLPSFEVGIRALCEVNNAEGSCIEERNVDLKNNSLEIDQTENVKPMLRGRFQ 617
+ ++ + L E L E EE + L+ LE+ + + L+
Sbjct: 287 QRNQILSQQLQQMEAEHNTLRNTVETER---EESKILLEKMELEVAERKLSFHNLQEEMH 343
Query: 618 RPKPNLSRAGKKSVLSQGKTESESKNSHSKTSVEKNHVEKDKMNTLDILRMETTERENPE 677
+AG Q + E ES+ S ++E+ H + + T IL ++ T +E
Sbjct: 344 HLLEQFEQAG------QAQAELESRYS----ALEQKHKAEMEEKTSHILSLQKTGQELQS 393
Query: 678 A------ETVSVLGEKNCLQEGSQLKALRPVQVRGRLQKPKPNAGKAAERKEILISQEEI 731
A + +L +KN E + A Q+ +LQ+ + R + + Q E
Sbjct: 394 ACDALKDQNSKLLQDKN---EQAVQSAQTIQQLEDQLQQKSKEISQFLNR--LPLQQHET 448
Query: 732 GANVEKNENESCADRDTPQHMEDQSRKDFEEEDVILQPEKNDSF-QNVQPDEPKVLNECL 790
+ + + Q + +++ ++ V L+ EK +++ +E K NE L
Sbjct: 449 ASQTSFPD----VYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKL 504
Query: 791 SVQ------------ENNKANKLNQVPILRTRFQKPKPNIGRGTGRREISSKEEVLEKIL 838
S Q + + ++++ V I R + + G+ S K + L +L
Sbjct: 505 SSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEES-GQDVLENTFSQKHKELSVLL 563
Query: 839 VSGEMAAALRETVRLDTSPKEMVPAEINTKEMQSDLKETGRRAISPREKILDVIDDTIE- 897
+ + A ++L K A+ + Q ++K+ I+P K+ ++DT +
Sbjct: 564 LEMKEAQEEIAFLKLQLQGKRAEEADHEVLD-QKEMKQMEGEGIAPI-KMKVFLEDTGQD 621
Query: 898 ------METGLKAMGREICLREKTPEVIDATEEIDKDLEEAGRREISPQKNGPEE---VK 948
E+ L A+ +E + T +EEI L +AG S +++G + V
Sbjct: 622 FPLMPNEESSLPAVEKE---QASTEHQSRTSEEIS--LNDAGVELKSTKQDGDKSLSAVP 676
Query: 949 PLGEVETDLKATGNESSPREKTPEVTDATEEIDKNLEETGRRKISPRENGPEEVKPVDEM 1008
+G+ D + +S E A E +KNL+E + +IS EE K
Sbjct: 677 DIGQCHQD-ELERLKSQILELELNFHKAQEIYEKNLDEKAK-EISNLNQLIEEFKK---- 730
Query: 1009 ETDLNATGRESSPREKTPEVIDATEEIDLEETEREVSPQENGLEEVKPLGEMETDLKATG 1068
D N++ + E+ + E + E +V E L E + ++ + + T
Sbjct: 731 NADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQ-TA 789
Query: 1069 RDSFPRGKTPEVIDAIEEIEIDLEETEREISPQENGLEEVK-PLGEMQTDLKATGREISP 1127
D+ + + I + I+ + + +I +N L++V+ E T +++ ++
Sbjct: 790 HDNL-------LTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQN 842
Query: 1128 REKTPEVIDATEEI---------------DKDLEETGRREISPEENGPEE-----VKPVD 1167
+E EV++ E + K+LE T ++ E+ E ++ D
Sbjct: 843 KES--EVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKD 900
Query: 1168 EMETDLK---------------TTGREGSSREKTREVIDAAEVIETDLEETEREISPQ-E 1211
+ T++ + G E + ++ ++ AE + + E + E+S +
Sbjct: 901 QQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLK 960
Query: 1212 NGPEEVKPVGKM-------ETDL---------KEIREEISQREKVLAEFSAIREKEIDLK 1255
+E+ P G++ E DL ++++ + R+++L S + E+ +LK
Sbjct: 961 QNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLK 1020
Query: 1256 ETGKRDIPIMEKVSGKM---------------AVVEEMEADLKETGKE------NFRERG 1294
+ K++IP+ E G++ + +E+E LK+T E + R+
Sbjct: 1021 DESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDL 1080
Query: 1295 SEEICVTEEKVAELKQTGKT--DISPRENELEETSTSRQTDTHLMQSGSNDFSAVPSLDI 1352
E++ E+ A +KQ +T D + + + L+ + Q + + + D S S+ +
Sbjct: 1081 EEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVAL 1140
Query: 1353 ---------------QNISSEVLSMMHTPVEEKRNSEKEVSSHFSHFKI------SSQTH 1391
++ E+ + +EK +K++ + K + H
Sbjct: 1141 VKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERH 1200
Query: 1392 ESDKTEVQGIQSPDVPEQFSDINL-SKSLPQEQKPLEIKPAPFVRSRFKRPKPNLARAAL 1450
++ + Q + EQF + + ++++ + + L+I+ VR P+ +
Sbjct: 1201 LREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQ----VRESIDGKLPSTDQQES 1256
Query: 1451 KRETTESEKYIYEKKSETKKMETIVMQENNEQTDTLPSQHDEASLM-----ISREKDTLG 1505
T E+ +++ T++ T + E+N D PS ++AS + +++ K L
Sbjct: 1257 CSSTPGLEEPLFK---ATEQHHTQPVLESNLCPD-WPSHSEDASALQGGTSVAQIKAQLK 1312
Query: 1506 HRNEEAVIL----PCTQTERNLSPSNSCEPKEE--SQSAPVQKNDSVVSVGTNNVNTFQQ 1559
E V L T +E + +E+ Q ++ +V + + QQ
Sbjct: 1313 EIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQ 1372
Query: 1560 EMKESVIQTARQVRGRLQRPR-PNIRKTGQRQIVDKGEAKGIIKEGRTILPKDETEKKVL 1618
+++ S +Q A R +P+ ++K ++ D G + E L K +TE
Sbjct: 1373 KLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQ 1432
Query: 1619 TVSNSQIETEIEVPSSAVPEHRMYENQSQVVLVENLHVNKTNETIRHENKPYVPSSAQMT 1678
+ T++E+ + EH Q QV L E + + E I E++ + Q
Sbjct: 1433 EDLIKALHTQLEMQAK---EHDERIKQLQVELCE---MKQKPEEIGEESR-----AKQQI 1481
Query: 1679 RRKFQKA----KPNLGRAHSKKEEPVLEKVTTDQ------------SKEGKPEDHLLQKG 1722
+RK Q A K L S +EE L + T ++ S + K +D +L +
Sbjct: 1482 QRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRL 1541
Query: 1723 ASNTQLLLKEKAELLTS-----LEVSARKDCVGSKESAL-------AKIDAELEEVGPSR 1770
A LL +E+ +L+T LE + S + AL K+ E+E + S
Sbjct: 1542 A----LLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESL-KSS 1596
Query: 1771 RVGEETVGDNSPSSVVEEQYL---------NKLTSCPQPLNETSYSKIALDGK--TTISS 1819
++ E T + +E + N+ + K L GK +T ++
Sbjct: 1597 KIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEAN 1656
Query: 1820 TSEYERNRGE-RRSHKKFKPNVTRGRGSK------------RVRGKTSKKEPRASKAMLV 1866
E E+ E + ++ K + + SK R+R + A + M
Sbjct: 1657 KKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMET 1716
Query: 1867 TLRASQEEDDDADDFESDYEEESYHLAPEEVNKAPVFVPVGLRSPEPVSAQIEETMEELE 1926
L ++ ++ + + +YE S K + +S ++++ ++E
Sbjct: 1717 LLSSNASMKEELERVKMEYETLSKKFQSLMSEK------------DSLSEEVQDLKHQIE 1764
Query: 1927 ITVNVPDVGCIAVVEHELPNTDVTTE-------EMKQEENLSVPFEMTTSEHIQDEPGTN 1979
NV + E T+VT E E +++++LS+ T SE + N
Sbjct: 1765 --GNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSAN 1822
Query: 1980 DGSTEAAITLLTMGDLVLQSEISSEQGDVGVCIIPHVHSKDKSHIPSSLDNVNHKIVHEC 2039
++ + + + + Q + E+ + + K+K +L+N + ++
Sbjct: 1823 PAVSKDFSSHDEINNYLQQIDQLKER----IAGLEEEKQKNK-EFSQTLENEKNTLL--- 1874
Query: 2040 QELSSPVITTSPASFEENKIVLEEQSSREEISLMEKVKENATPTRNTISKVTSNLRIRSR 2099
++S+ E K+ L Q +EE+S + K+KE A ++ + + R+ ++
Sbjct: 1875 SQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEE-----RLMNQ 1929
Query: 2100 LAKPKPNL--------EKTLGTNRLDDYQEVSSLCVTKGAEMETQRETEKNASKATELEN 2151
LA+ ++ + + L+ + CV++ E E Q+ ++ +E+
Sbjct: 1930 LAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSE-LEEEKQQLVKEKTKVESEIRK 1988
Query: 2152 KNLGPVTTAENKDQSK 2167
+ L + A+ + +K
Sbjct: 1989 EYLEKIQGAQKEPGNK 2004
Score = 48.5 bits (114), Expect = 9e-05
Identities = 218/1262 (17%), Positives = 465/1262 (36%), Gaps = 178/1262 (14%)
Query: 911 LREKTPEVIDATEEIDKDLEEAGRREISPQKNGPEEVKPLGEVETDLKATGNESSPREKT 970
+R+K ++ E + ++ + A + + + ++ L + ++KA G P E
Sbjct: 68 IRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQ 127
Query: 971 PEVTDATEEIDKNLEETGRRKISPRENGPEEVKPVDEMETDLNATGRESSPREKTPEVID 1030
E + + EE KI + EE+ + ++ L E + T
Sbjct: 128 SEEQLSKHDKSSTEEEMEIEKIKHKLQEKEEL--ISTLQAQLTQAQAEQPAQSST----- 180
Query: 1031 ATEEIDLEETEREVSPQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEVIDAIEEIEID 1090
E E V ++ E+ + + ++ L T + + E DA E ++
Sbjct: 181 --------EMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREK-DARFETQVR 231
Query: 1091 LEETEREISPQENGLEEVKPLGEMQTDLKATGREISPREKTPEVIDATEEIDKDLEETGR 1150
L E E + +E EMQ L+ R++ E++ ++ + +D +E
Sbjct: 232 LHEDELLQLVTQADVET-----EMQQKLRVLQRKLEEHEES--LVGRAQVVDLLQQEL-- 282
Query: 1151 REISPEENGPEEVKPVDEMETDLKT-TGREGSSREKTREVIDAAEVIETDLEETEREISP 1209
+ E+ + + +ME + T + RE+++ +++ E LE ER++S
Sbjct: 283 --TAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKME-----LEVAERKLS- 334
Query: 1210 QENGPEEVKPVGKMETDLKEIREEISQREKVLAE----FSAIREKEIDLKETGKRDIPIM 1265
++ ++ + E+ Q + AE +SA+ +K E I +
Sbjct: 335 ----------FHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSL 384
Query: 1266 EKVSGKMAVVEEMEADLKETGKENFRERGSEEICVTEEKVAELKQTGKTDISPRENELEE 1325
+K ++ + D ++ E+ + ++ +L+Q K +IS N L
Sbjct: 385 QKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSK-EISQFLNRLPL 443
Query: 1326 TSTSRQTDTHLMQSGSNDFSAVPSLDIQNISSEV---------LSMMHTPVEEKRNSEKE 1376
+ T + AV +I ++ V L + +EE + ++
Sbjct: 444 QQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEK 503
Query: 1377 VSSHFSHFKISSQTHESDK-------TEVQGIQSPDVPEQFSDINLSKSLPQEQKPLEIK 1429
+SS + + ++T E+D+ ++ +S E D+ L + Q+ K L +
Sbjct: 504 LSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDV-LENTFSQKHKELSV- 561
Query: 1430 PAPFVRSRFKRPKPNLARAALKRETTESEKYIYE--KKSETKKME---------TIVMQE 1478
+ K + +A L+ + +E+ +E + E K+ME + +++
Sbjct: 562 ----LLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLED 617
Query: 1479 NNEQTDTLPSQHDEASL-MISREKDTLGHR---------NEEAVILPCTQTERNLSPSNS 1528
+ +P ++E+SL + +E+ + H+ N+ V L T+ + + S S
Sbjct: 618 TGQDFPLMP--NEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAV 675
Query: 1529 CEPKEESQSAPVQKNDSVVSVGTNNVNTFQQEMKESVIQTARQVRGRLQRPRPNIRKTGQ 1588
+ + Q + ++ + N + Q+ ++++ + A+++ Q + + +
Sbjct: 676 PDIGQCHQDELERLKSQILELEL-NFHKAQEIYEKNLDEKAKEISNLNQ-----LIEEFK 729
Query: 1589 RQIVDKGEAKGIIKEGRTILPKDETEKKVLTVSNSQIETEIEVPSSAVPEHRMYENQSQV 1648
+ + A + E R L E ++T +Q++ ++E+ + R + +SQ
Sbjct: 730 KNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVK-QLEMNLAEAERQRRLDYESQT 788
Query: 1649 ----VLVENLH---VNKTNETIRHENKPYVPSSAQMTRRKFQKAKPNLGRAHSKKEEPVL 1701
+L E +H + ++ ++ E Q+ + +L KE VL
Sbjct: 789 AHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVL 848
Query: 1702 EKVTTDQSKEGKPEDHLLQKGASNTQLLLKEKAELLTSLEVSARKDCVGSKESALAKIDA 1761
E + K E+ L + S +L + + +LL +K V + + + + D
Sbjct: 849 EGAERVRHISSKVEE--LSQALSQKELEITKMDQLLLE-----KKRDVETLQQTIEEKDQ 901
Query: 1762 ELEEVGPSRRVGEETVGDNSPSSVVEEQYLNKLTSCPQPLNETSYSKIALDGKTTISSTS 1821
++ E+ S + + S VE + L + + E ++ D
Sbjct: 902 QVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDN-------- 953
Query: 1822 EYERNRGERRSHKKFKPNVTRGRGSKRVRGKTSKKEPRASKAMLVTLRASQEEDDDADDF 1881
E + G ++++ + P + + KKE K L +++E
Sbjct: 954 --EVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKE---LLQR 1008
Query: 1882 ESDYEEESYHLAPEEVNKAPVFVPVGLRSPEPVSAQIEETMEELEITVNVPDVGC----- 1936
S EEE +L E + P+ E ++EE E E + C
Sbjct: 1009 VSRLEEELANLKDESKKEIPL--------SETERGEVEEDKENKEYSEKCVTSKCQEIEI 1060
Query: 1937 -----IAVVEHELPNTDVTTEEMKQEENLSVPFEMTTSEHIQDEPGTNDGSTEAAITLLT 1991
I+ E EL + EE E ++ +QD+ D
Sbjct: 1061 YLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQID----------- 1109
Query: 1992 MGDLVLQSEISSEQGDVGVCIIPHVHSKDKSHIPSSLDNVNHKIVHECQELSSPVITTS- 2050
+LQ+EIS Q + I + + D + +V E +S P +S
Sbjct: 1110 ----LLQAEISENQAIIQKLITSNTDASDGDSV---------ALVKETVVISPPCTGSSE 1156
Query: 2051 --PASFEENKIVLEEQSSREEISLMEKVKENATPTRNTISKVTSNLR-IRSRLAKPKPNL 2107
EE + LE +E+ L +K++E T + + K R +R L + K +
Sbjct: 1157 HWKPELEEKILALE----KEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDY 1212
Query: 2108 EK 2109
+
Sbjct: 1213 NR 1214
Score = 37.4 bits (85), Expect = 0.20
Identities = 103/535 (19%), Positives = 213/535 (39%), Gaps = 59/535 (11%)
Query: 372 QKVLAEEEKRKQKSVKNHSLKEKKSTKPRKNVKVKKVACEGVNNDPDESMSSRISDTERS 431
+ ++ EEE +K K + L E T ++N++ K V +SMSS +D +R
Sbjct: 2423 ENIVLEEENKKAVD-KTNQLMETLKTIKKENIQQKAQLDSFV-----KSMSSLQNDRDRI 2476
Query: 432 QKDAQTVEEESLTLSREDAEQVALEVDLNQKKRRRKKQDGANELGVNNLLENATVQAGPS 491
D Q +EE L++ E + + N K + + ++ +N+ ENA + A
Sbjct: 2477 VGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNS--ENAKLDAELI 2534
Query: 492 KGEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGIVGFASTEKVEKRTDPILSLSNQQD 551
+ + N+ I K+ + + + QN + +A E+ K ++ + + +
Sbjct: 2535 QYREDLNQVITI----KDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEE--ANEDLRR 2588
Query: 552 ATSVATESSESSTSDLPSFEVGIRALCEVNNAEGSCIEERNVDLKNNSLEIDQTENVKPM 611
+ + E + + ++ S +V I L A EE + L + L++ + E +
Sbjct: 2589 SFNALQEEKQDLSKEIESLKVSISQLTRQVTA---LQEEGTLGLYHAQLKVKEEEVHR-- 2643
Query: 612 LRGRFQRPKPNLSRAGKKSVLSQGKTESESKNSHSKTSVEKNHVEKDKMNTLDILRMETT 671
L F + ++ ++ V Q + + K E H+ D I+R ET
Sbjct: 2644 LSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHD----AGIMRNETE 2699
Query: 672 ERENPEAETVS--VLGEKNCLQEGSQLKAL-RPVQVRGR----LQKPKPNAGKA------ 718
E AE V E+ L + K L +Q GR LQ + +A +
Sbjct: 2700 TAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKR 2759
Query: 719 ---AERKEI-------LISQEEIGANVEKNENESCADRDTPQHME--DQSRKDFEEEDVI 766
A KE+ L+++E E + + + ++ H+E +Q +E+ +
Sbjct: 2760 KYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLH 2819
Query: 767 LQPEKNDSFQNVQPDEPKVLNECLSVQENNKANKLNQVPILRTRFQ-KPKPNIGRGTGRR 825
L + DS+ VQ ++ ++ +N + + N++ R + K + T
Sbjct: 2820 LSSQLEDSYNQVQS-----FSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPA 2874
Query: 826 EISSKEEVLEKI-----LVSGEMAAALRETVRLDTSPKEMVPAEINTKEMQSDLK 875
E+ S ++ + + + E+ ++ ++++ E+ P + +E Q K
Sbjct: 2875 EVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTK 2929
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 75.9 bits (185), Expect = 5e-13
Identities = 324/1751 (18%), Positives = 659/1751 (37%), Gaps = 256/1751 (14%)
Query: 421 MSSRISDTERSQKDAQTVEEESLTLSREDAEQVAL--------EVDLNQKKRRRKKQDGA 472
+ +R+S Q D +E L +E+ E +++ ++D+N K + QD
Sbjct: 1273 LQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQD-- 1330
Query: 473 NELGVNNLLENATVQAGPSKGEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGIVGFAS 532
LE ++ + ++ ++ +++ +LKE E + E + C Q V
Sbjct: 1331 --------LEKTKLE---EQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVS--- 1376
Query: 533 TEKVEKRTDPILSLSNQQDATSVATESSESSTSDLPSFEVGIRALCEVNNAEGSCIEERN 592
E P L + SV S++ + P GSC++ +N
Sbjct: 1377 ----ESTVPPSLPVD------SVVITESDAQRTMYP----------------GSCVK-KN 1409
Query: 593 VDLK---NNSLEIDQTENVKPMLRGRFQRPKPN------------LSRAGKKSVLSQGKT 637
+D + + + N+ +L ++Q ++ + S +S GK
Sbjct: 1410 IDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKE 1469
Query: 638 ES-ESKNSHSKTSVEKNHVEKDKMN-------TLDILRMETTERENPEAETVSVLGEKNC 689
+ SK +H+ E+++ + K++ T + + ++ E P ++ + G++
Sbjct: 1470 NTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEIL 1529
Query: 690 LQEGS-----QLKALRPVQVRGRLQKPKPNAGKAAERKEILISQEEIGANVEKNEN--ES 742
L + K K K + + EI +S + + NE E
Sbjct: 1530 LSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLED 1589
Query: 743 CADRDTPQHMEDQSRKDFEEEDVILQPEKNDSFQNVQPDEPKVLNECL----SVQENNKA 798
Q+ E Q + + + Q E+ Q +E K LN L S+ N
Sbjct: 1590 MRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLV 1649
Query: 799 NKLNQVPILRTRFQKPKPNIGRGTGRREI-SSKEEVLEKILVSGEMAAALRETVRLDTSP 857
++ +V + K GR E+ +S + GE+ + LD P
Sbjct: 1650 SERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKP 1709
Query: 858 KEMVPAEINTKEMQSDLKETGRRAISPREKILDVIDDTIEMETGLKAMGREICLREKTPE 917
++ VP EI + E + L++ R + + +L+V+ T +E + +GR +
Sbjct: 1710 ED-VPPEILSNERYA-LQKANNRLL---KILLEVVKTTAAVE---ETIGRHVL------G 1755
Query: 918 VIDATEEIDKDLEEAGRREISPQKNGPEEVKPLGEVETDLKATGNESSPREKTPEVTDAT 977
++D + + R E + + + + PR + T
Sbjct: 1756 ILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVT 1815
Query: 978 EEIDKNLEETGRRKISPRENGPEEVKPVDEMETDLNATGRESSPREKTPEVIDATEEIDL 1037
EE + + R + E PE E LN + R + EK E I T L
Sbjct: 1816 EEGTELSQRLVRSGFAGTEIDPENE------ELMLNISSRLQAAVEKLLEAISETSS-QL 1868
Query: 1038 EETEREVSPQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEVIDAIEEIEIDLEETERE 1097
E + V+ E E + E LK R + E A E++ ++L + E
Sbjct: 1869 EHAK--VTQTELMRESFRQKQEATESLKCQEE---LRERLHEESRAREQLAVELSKAEGV 1923
Query: 1098 ISPQENGLEEVKPLGEMQ----TDL--KATGREISPREKTPEVIDATEEIDKDLEETGR- 1150
I +G + K L E Q TD+ + + + E+ ++I ++ E R
Sbjct: 1924 I----DGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQ 1979
Query: 1151 REISPEENGPEEVKPVDEMETDLKTTGREGSSREKTREVIDA-AEVIETDLEE-TEREIS 1208
+E E GP E + + E E +K EK R+ + + +E D+EE R I
Sbjct: 1980 KEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIE 2039
Query: 1209 PQENGPEEVKPVGKMETDLKEIREEISQREKVLAEFSAIREKEIDLKETGKRDIPIMEKV 1268
++ E+ + + L++ ++ + K L E + RE E D+ + + + KV
Sbjct: 2040 LEQEKNTELMDLRQQNQALEK---QLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKV 2096
Query: 1269 SGKMAVVEEMEADLKETGKENFRERGSE--EICVTEEKVAELKQTGKTDISPRENELEET 1326
+ + E + E + +E+ + E+ +++E++ + DI R E+E+
Sbjct: 2097 VPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQL-------QRDIQERNEEIEKL 2149
Query: 1327 STS-RQTDTHLMQSGSNDFSAVPSLDIQNISSEVLSMMHTPVEEKRNSEKEVSSHFSHFK 1385
R+ + L+ F AV + +S EV +++ EKE+++ +
Sbjct: 2150 EFRVRELEQALLVEDRKHFGAVEAKP--ELSLEVQLQAERDAIDRK--EKEITNLEEQLE 2205
Query: 1386 ISSQTHESDKTEVQGIQSPDVPEQFSDINLSKSLPQEQKPLEIKPAPFVRSRFKRPKPNL 1445
+ E+ EVQ + ++ + L QE K FK L
Sbjct: 2206 QFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENK------------LFKDDMEKL 2253
Query: 1446 ARAALKRE--TTESEKYIYEKKSETKKMETIVMQENNEQTDTLPSQHDEASLMISREKDT 1503
A + + +T+ + ++ K ++ + + + + + NEQ L Q L I+ +
Sbjct: 2254 GLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQ-----LKITTDNKV 2308
Query: 1504 LGHRNEEA----VILPCTQTERNLSPSNSCEPKEESQSAPVQKNDSVVSVGTN---NVNT 1556
+ +NE + C +++ N E E+ + + ++G N ++
Sbjct: 2309 IEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHS 2368
Query: 1557 FQQE---MKESV-IQTARQVRGRLQRPRPNIRKTGQRQIVDKGEAK--GIIKEGRTILPK 1610
+E +K + + A ++ Q N T + ++ + K + +E ++ +
Sbjct: 2369 LSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRE 2428
Query: 1611 DETEKKVLTVSNSQIETEIEVPSSAVPEHRMYENQSQVVLVENLHVNKTNETIRHENKPY 1670
E+ +K+ ++ + + I+ S PE +VVL E+ + N+T Y
Sbjct: 2429 RESVEKIQSIPENSVNVAIDHLSKDKPE-------LEVVLTEDALKSLENQT-------Y 2474
Query: 1671 VPSSAQMTRRKFQKAKPNLGRAHSKKEEPVLE-----KVTTDQSKEGKPEDHLLQKGASN 1725
S + + + L + S LE K D ++G+ E +LQK N
Sbjct: 2475 FKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVN 2534
Query: 1726 TQLLLKEK--AELLTSLEVSA-----------------------------RKDCVGSKES 1754
Q +++EK A L++ +++ A R+D +GS S
Sbjct: 2535 LQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDIS 2594
Query: 1755 AL----AKIDAELEEVGPSRRVGEETVGDNSPSSVVEEQ----YLNKLTSCPQPLNETSY 1806
AL +++++++ E+ S + +E V + + +V+E++ L KL +
Sbjct: 2595 ALTLRISELESQVVEMHTSLILEKEQV-EIAEKNVLEKEKKLLELQKLLEGNEKKQREKE 2653
Query: 1807 SKIALDGKTTISSTSEYERNRGERRSHKKFKPNVTRGRGSKRVRGKTSKKEPRASKAMLV 1866
K + + +T+E + E + + +K +K + + +LV
Sbjct: 2654 KKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLV 2713
Query: 1867 ---TLRASQEEDDDADDFESDYEEESYHLAPE------EVNKAPVFVPVGLRSPEPVSAQ 1917
+ + Q++ D ++ +E+ L E E KA +F P+ ++ + +++Q
Sbjct: 2714 KETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQ 2773
Query: 1918 IEETME----ELEITVNVPDVGCIAVVEHELPNTDVTTEEMKQEENLSVPFEMTTSEHIQ 1973
+ T++ + V + G ++ E + +VT + E + E+ +E I
Sbjct: 2774 TDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAE-IL 2832
Query: 1974 DEPGTNDGSTEAAITLLTMGDLVLQSEISSEQGDVGVCIIPHVHSKDKSHIPSSLDNVNH 2033
D + TE L V + E G + +I + SK+ S IP + H
Sbjct: 2833 DMESRHISETET----LKREHYVAVQLLKEECGTL-KAVIQCLRSKEGSSIP----ELAH 2883
Query: 2034 KIVHECQELSS 2044
++ +E+ S
Sbjct: 2884 SDAYQTREICS 2894
Score = 57.4 bits (137), Expect = 2e-07
Identities = 225/1225 (18%), Positives = 463/1225 (37%), Gaps = 198/1225 (16%)
Query: 375 LAEEEKRKQKSVKNHSLKEKKSTKPRKNVKVKKVACEGVNNDPDESMSSRISDTERSQKD 434
LA+ +RK +S K++K + + K A +N D + I+ ++R +
Sbjct: 17 LAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQCNEMYINSSQRVEST 76
Query: 435 A-------QTVEEESLTLSREDAEQVALEVDLNQKKRRRKKQDGA--------------- 472
+T+ +T S E V LE +++ +
Sbjct: 77 VIPESTIMRTLHSGEIT-SHEQGFSVELESEISTTADDCSSEVNGCSFVMRTGKPTNLLR 135
Query: 473 -NELGVNNLLENATVQAGPSKGEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGIVGFA 531
E GV++ Q P+ E +++ + E++E E+M T +G+
Sbjct: 136 EEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEM-RVTYGTEGLQQLQ 194
Query: 532 STEKVEKRTDPILS--LSNQQDATSVATESSESS---TSDLPSFEVGIRALCEVNNAEGS 586
E K+ D I++ +N Q A E+ T ++ + L S
Sbjct: 195 EFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNS 254
Query: 587 CIEERNVDL---KNNSLEIDQTENVKPMLRGRFQRPKPN----LSRAGKKSVLSQGKTES 639
DL K L Q + L +Q+ K + +S +K + + + +
Sbjct: 255 THSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDK 314
Query: 640 ESKNSHSKTSVEKNHVEKDKMNTLDILRMETTERENPEAETVSVLGE--KNCLQEGSQLK 697
+ +NS+ + EK + ++ + +T E ++ +LGE + +Q+ ++K
Sbjct: 315 KVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIK 374
Query: 698 ALRPVQVRGRLQKPKPNAGKAAERKEILISQEEIGANVEKNENESCADRDTPQHMEDQSR 757
++ +++ QK + ++ E K+++ + EE+ ++N +S + D Q ME +++
Sbjct: 375 NMK-LELTNSKQKERQSS---EEIKQLMGTVEELQ---KRNHKDSQFETDIVQRMEQETQ 427
Query: 758 KDFEEEDVILQPEKNDSF--QNVQPDEPKVLNECLSVQENNKANKLNQVPILRTRFQKPK 815
+ E+ L+ E ++ + Q VQ + + ++E ++TR +
Sbjct: 428 RKLEQ----LRAELDEMYGQQIVQMKQELIRQHMAQMEE------------MKTRHK--- 468
Query: 816 PNIGRGTGRREISSKEEVLEKILVSGEMAAALRETVRLDTSPKEMVPAEINTKEMQSDLK 875
GEM ALR + + ++ + E+ L+
Sbjct: 469 -------------------------GEMENALRSYSNITVNEDQIKLMNVAINELNIKLQ 503
Query: 876 ETGRRAISPREKILDVIDDTIEMETGLKAMGREICL-REKTPEVIDATEEIDKDLEEAG- 933
+T + +E++ ++++ ++ L+ + E+ RE+ E + L EA
Sbjct: 504 DTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHK 563
Query: 934 --------RREISPQKNGPEEVKPLGEVETDLKATGNESSPREKTPEVTDATEEIDKNLE 985
+ EI +E++ E E E +EK + E + LE
Sbjct: 564 SLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELE 623
Query: 986 ETGRRKISPRENGPEEVKPVDEMETDLNATGRESSPREKTPEVIDA-----TEEIDLEET 1040
+ + E ++K E+E +N + + + ID +++I+ +
Sbjct: 624 RLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQF 683
Query: 1041 ERE--VSPQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEVIDAIEEIEIDLEETEREI 1098
E++ ++ Q + E+ L +++ L +S T ++ + +EIEI L + E+E
Sbjct: 684 EKDNLITKQNQLILEISKLKDLQQSLV----NSKSEEMTLQINELQKEIEI-LRQEEKEK 738
Query: 1099 SPQENGLEEVKPLGEMQTDLKATGREISPREKTPEVIDATEEIDKDLEET------GRRE 1152
E ++E++ E+ + + +E +EK + ++A I KD ++T
Sbjct: 739 GTLEQEVQELQLKTEL-LEKQMKEKENDLQEKFAQ-LEAENSILKDEKKTLEDMLKIHTP 796
Query: 1153 ISPEEN---------------GPEEVKPVDEMETDLKTTGRE-GSSREKTREVIDAAEV- 1195
+S EE +E++ + E DLK + EK R AE
Sbjct: 797 VSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKN 856
Query: 1196 IETDLEETERE---ISPQENGPEEVKPVGKME--TDLKEIREE----------ISQREKV 1240
E + +E + E + ++ E+ K ++E + LK + EE + + V
Sbjct: 857 FEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSV 916
Query: 1241 LAEFSAIREKEIDLKETGKRD-IPIMEKVSGKMAVVEEMEADLKETGKENFRERGSEEIC 1299
E + +++ E ++D +MEK+ E+ L + ++ ++ G EI
Sbjct: 917 FDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHG--EIS 974
Query: 1300 VTEEKVAELKQTGKTDISPRENELEETSTSRQTDTHLMQSGSNDFSAVPSLDIQNISSEV 1359
E+V LKQ K +S R ELE + + ++Q+ ++V
Sbjct: 975 FLNEEVKSLKQE-KEQVSLRCRELEIIINHNRAE-----------------NVQSCDTQV 1016
Query: 1360 LSMMHTPVE-EKRNSEKEVSSHFSHFKISSQTHESDKTEVQGIQSPDVPEQFSDINLSKS 1418
S++ V R +E VS F S+ DK F ++ + +
Sbjct: 1017 SSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKV------------SFENMTVGEE 1064
Query: 1419 LPQEQKPLEIKPAPFVRSRFKRPKPNLARAALKRETTESEKYIYEKKSETKKMETIVMQE 1478
QEQ L+ P+ S + +P+ E + +K + KSE + + M+
Sbjct: 1065 SKQEQLILDHLPSVTKESSLRATQPS--------ENDKLQKELNVLKSEQNDLR-LQMEA 1115
Query: 1479 NNEQTDTLPSQH-DEASLMISREKD 1502
+ S H D+ + EKD
Sbjct: 1116 QRICLSLVYSTHVDQVREYMENEKD 1140
Score = 57.0 bits (136), Expect = 2e-07
Identities = 243/1349 (18%), Positives = 499/1349 (36%), Gaps = 197/1349 (14%)
Query: 419 ESMSSRISDTERSQKDAQTVEEESLTLSREDAEQVALEVDLNQKKR---RRKKQDGANEL 475
+S S + D E+++ + Q E ESL S +Q E + N + +K+ +E
Sbjct: 1322 KSKLSSLQDLEKTKLEEQVQELESLISS---LQQQLKETEQNYEAEIHCLQKRLQAVSES 1378
Query: 476 GVNNLLENATVQAGPSKGEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGIVGFASTEK 535
V L +V S ++ + G C K+ NIDG + F+
Sbjct: 1379 TVPPSLPVDSVVITESDAQR----------TMYPGSCVKK-------NIDGTIEFSGEFG 1421
Query: 536 VEKRTDPILSLSNQQDA--------TSVATESSESSTSDLPSFEVGIRALCEVNNAEGSC 587
V++ T+ + L Q V+ + + ++L G A C
Sbjct: 1422 VKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVC 1481
Query: 588 IEERN----VDLKNNSLEIDQTENVKPMLRGRFQRPKPNLSRAGKKSVLSQGK------- 636
+E++ + L + + E V + F+ L GK+ +LS
Sbjct: 1482 QQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPES 1541
Query: 637 -----TESESKNSHSKTSVEKNHVEKD--------------KMNTLDILRMETTERENPE 677
T SE S KT + + + + L+ +R E +
Sbjct: 1542 KDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEH 1601
Query: 678 AETVSVLGEKNCLQEGSQLKALRPVQVR-GRLQKPKP------NAGKAAERKEILISQEE 730
+ +L + + Q Q + +Q RL + N +ER+ +L+ + E
Sbjct: 1602 QQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELE 1661
Query: 731 I--GANVEKNENESCADRDTPQHMEDQSRKDFEEEDVILQPEKNDSFQNVQPDEPKVL-N 787
++ E C R++ ++ + E E+ + ++ D P P++L N
Sbjct: 1662 ALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVP--PEILSN 1719
Query: 788 ECLSVQENNKANKLNQVPILRTRFQKPKPNIGRGT-GRREISSKEEVLEKILVSGEMAAA 846
E ++Q+ N + +++T + IGR G + SSK + ++ E A+
Sbjct: 1720 ERYALQKANNRLLKILLEVVKTT-AAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEAS 1778
Query: 847 LRETVRLDTS--PKEMVPAEI------NTKEMQSDLKETGRRAISPREKILDVIDDTIEM 898
++ V + + E +P+ N M S + E G +S R I+
Sbjct: 1779 VKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTE-LSQRLVRSGFAGTEIDP 1837
Query: 899 ETGLKAMGREICLREKTPEVIDATEEIDKDLEEAG-------RREISPQKNGPEEVKPLG 951
E + L+ ++++A E LE A R ++ E +K
Sbjct: 1838 ENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQE 1897
Query: 952 EVETDLKATGNESSPREKTP-EVTDATEEIDKNLEETGRRKISPRENGPEEVKPVDEMET 1010
E+ L ES RE+ E++ A ID +E K E+ +D +E
Sbjct: 1898 ELRERLH---EESRAREQLAVELSKAEGVIDGYADE----KTLFERQIQEKTDIIDRLEQ 1950
Query: 1011 DLNATGRESSPREKTPEVIDATEEIDLEETEREVSPQENGLEEVKPLGEMETDLKATGRD 1070
+L E + I EE +L ++E E G E + L E E +K
Sbjct: 1951 ELLCASNRLQELEAEQQQIQ--EERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEV 2008
Query: 1071 SFPRGKTPEVIDA-IEEIEIDLEETEREISPQENGLEEVKPLGEMQTDLKATGREISPRE 1129
K + + ++ +EID+EE E E+ L +++ +A +++
Sbjct: 2009 QCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQ--EKNTELMDLRQQNQALEKQLEKMR 2066
Query: 1130 KTPEVIDATEEIDKDLEETGRREISPEENGPEEVKPVDEMETDL--KTTGREGSSREKTR 1187
K + E ++D+ + +++ + +P+ E +T + +K
Sbjct: 2067 KFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCS 2126
Query: 1188 EVIDAAEVIETDLEETEREISPQEN-----------------GPEEVKPVGKMETDLKEI 1230
E++ + E ++ D++E EI E G E KP +E L+
Sbjct: 2127 ELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAE 2186
Query: 1231 REEISQREKVLAEFSAIREKEIDLKETGKRDIPIMEKVSGKMAVVEEMEADLKETGKENF 1290
R+ I ++EK + E++++ E++ K V+++ L+ KE
Sbjct: 2187 RDAIDRKEKEITNL----EEQLE---------QFREELENKNEEVQQLHMQLEIQKKE-- 2231
Query: 1291 RERGSEEICVTEEKVAELKQTG---KTDISPRENELEETSTSRQTDTHLMQSGSNDFSAV 1347
+ ++ EL+Q K D+ ++E+ D H++
Sbjct: 2232 ----------STTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQE 2281
Query: 1348 PSLDIQNISSEVLSMM--------HTPVEEKRNSEKEVSSHFSHFKISSQTHESDKTEVQ 1399
++I ++ +V + + +EEK +++ + + SD+ V+
Sbjct: 2282 KEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQI-------ECLMSDQECVK 2334
Query: 1400 GIQSPDVPEQFSDINLSKSLPQEQKPLEIKPAPFVRSRFKRPKPNLARAALKR--ETTES 1457
+ ++ EQ +++ + L QE + K + S + +LK + +
Sbjct: 2335 RNREEEI-EQLNEV--IEKLQQELANIGQKTSMNAHSLSEEAD------SLKHQLDVVIA 2385
Query: 1458 EKYIYEKKSETKKMETIVMQENNEQTDTLPSQHDEASLMISREKDTLGHRNEEAVILPCT 1517
EK E++ ET E M+ ++T+ +Q + + RE++++ E+ +P
Sbjct: 2386 EKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESV----EKIQSIP-- 2439
Query: 1518 QTERNLSPSNSCEPKEESQSAPVQKNDSVVSVGTNN-VNTFQQEMKESVIQTAR---QVR 1573
E +++ + K++ + V D++ S+ +F++ K S+I Q+
Sbjct: 2440 --ENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLE 2497
Query: 1574 GRLQRPRPNIRKTGQ--RQIVDKGEAKGIIKEGRTILPKDETEKKVLTVSNSQIETEIEV 1631
+ + + + + + ++G+ + + + + + + E+KV SQI+ E
Sbjct: 2498 STVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLE--- 2554
Query: 1632 PSSAVPEHRMYENQSQVVLVENLHVNKTN 1660
AV E+ + +Q + E N N
Sbjct: 2555 ---AVQEYAKFCQDNQTISSEPERTNIQN 2580
Score = 52.4 bits (124), Expect = 6e-06
Identities = 119/665 (17%), Positives = 258/665 (38%), Gaps = 103/665 (15%)
Query: 923 EEIDKDLEEAGRREISPQKNGPEEVKPLGEVETDLKATGNESSPREKTPEVTDATEEIDK 982
EE++++LEE G E ++ L E E +K + ++T ++ +
Sbjct: 172 EELNRELEEMR------VTYGTEGLQQLQEFEAAIKQRDGIIT------QLTANLQQARR 219
Query: 983 NLEETGRRKISPRENGPEEVKPVDEMETDLNATGRESSPREKTPEVIDATEEI------- 1035
+ET R + E + + + + T R S+ +++ A ++I
Sbjct: 220 EKDETMREFLELTEQSQK--LQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQL 277
Query: 1036 --------DLEETEREVSPQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEVIDAIEEI 1087
D ++ + + + Q + L+E + EME D K + + + E IEE+
Sbjct: 278 EEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSN---KEEIQEKETIIEEL 334
Query: 1088 EIDLEETEREISPQENGLEEV-KPLGEMQTDLKATGREISPREKTPEVIDATEEIDKDLE 1146
+ E E++ ++ L K LGE+Q + +EI + E+ ++ ++ + E
Sbjct: 335 NTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEI--KNMKLELTNSKQKERQSSE 392
Query: 1147 ETGRREISPEENGPEEVKPVDEMETDLKTTGREGSSREKTREVIDAAEVIETDLEETERE 1206
E + + EE K + ETD+ + + R+ + + E+ + + ++E
Sbjct: 393 EIKQLMGTVEELQKRNHKD-SQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQE 451
Query: 1207 ISPQENGP-EEVKP--VGKMETDLKEIREEISQREKVLAEFSAIREKEIDLKETGKRDIP 1263
+ Q EE+K G+ME L+ +++ AI E I L++T +
Sbjct: 452 LIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQK-- 509
Query: 1264 IMEKVSGKMAVVEEMEADLKETGKENFRERGSEEICVTEEKVAELKQTGKTDISPRENEL 1323
EK+ ++ ++ E + L+ ++ EE+ + E++ +QT I+ +E++L
Sbjct: 510 --EKLKEELGLILEEKCALQRQLEDLV-----EELSFSREQIQRARQT----IAEQESKL 558
Query: 1324 EETSTSRQTDTHLMQSGSNDFSAVPSLDIQNISSEVLSMMHTPVEEKRNSEKEVSSHFSH 1383
E S T ++++ +E++S + E + E EV++
Sbjct: 559 NEAHKSLST-------------------VEDLKAEIVSASESRKELELKHEAEVTN---- 595
Query: 1384 FKISSQTHESDKTEVQGIQSPDVPEQFSDINLSKSLPQEQKPLEIKPAPFVRSRFKRPKP 1443
+KI + E +K V + + + E++ ++K
Sbjct: 596 YKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLK-------------- 641
Query: 1444 NLARAALKRETTESEKYIYEKKSETKKMETIVMQENNEQTDTLPSQHDEASLMISREKDT 1503
E E + +K++ + +Q D L ++ + + EKD
Sbjct: 642 --------------EDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDN 687
Query: 1504 LGHRNEEAVILPCTQTERNLSPSNSCEPKEESQSAPVQKNDSVVSVGTNNVNTFQQEMKE 1563
L + + ++ + S NS + Q +QK ++ T +QE++E
Sbjct: 688 LITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQE 747
Query: 1564 SVIQT 1568
++T
Sbjct: 748 LQLKT 752
Score = 47.0 bits (110), Expect = 2e-04
Identities = 302/1638 (18%), Positives = 643/1638 (39%), Gaps = 284/1638 (17%)
Query: 344 EEKTNGWRIDKAFQEKRPFDFDFFAHLLQKVLAEEEKRKQKSVKNHSLKEKKSTKPRKNV 403
+EKT ++ QEK D L Q++L + ++ + ++E++ R+
Sbjct: 1929 DEKT---LFERQIQEKT----DIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKE 1981
Query: 404 KVKKVAC---EGVNNDPDESMSSRISDTERSQKDAQTVEEESLTLSREDAEQVALEVDLN 460
+K A + + + ++ M ++ +++K ++++ L + EQV+ ++L
Sbjct: 1982 AMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELE 2041
Query: 461 QKKRRR----KKQDGANELGVNNLLENATVQAGPSKGEKH--KNKCQAIRPELKEGECSK 514
Q+K ++Q+ A E + + + QA + E+ + + Q + +LK +
Sbjct: 2042 QEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQ 2101
Query: 515 EQMLSCTQNIDGIVGFASTEKVEKRTDPILSLSNQQDATSVATESSESSTSDLPSFEVGI 574
T+ ++ + EK +K ++ +LS Q + ++ E +
Sbjct: 2102 PISEHQTREVEQLANHLK-EKTDKCSELLLSKEQLQ-------RDIQERNEEIEKLEFRV 2153
Query: 575 RALCEVNNAEGSCIEERN----VDLKNN-SLEID-QTENVKPMLRGRFQRPKPNLSRAGK 628
R L + +E+R V+ K SLE+ Q E R R + ++ +
Sbjct: 2154 REL-----EQALLVEDRKHFGAVEAKPELSLEVQLQAE------RDAIDRKEKEITNLEE 2202
Query: 629 KSVLSQGKTESESKNSHSKTSVEKNHVEKDKMNTLDILRMETTERENPEAETVSVLGEKN 688
+ L Q + E E+KN V++ H++ L+I + E+T R E E + L + +
Sbjct: 2203 Q--LEQFREELENKNEE----VQQLHMQ------LEIQKKESTTRLQ-ELEQENKLFKDD 2249
Query: 689 CLQEGSQLKALRPVQVRGRLQKPKPNAGKAAERKEILISQEEIGANVEKNENESCADRDT 748
+ G +K + Q GK A+ +I ++E+ D+
Sbjct: 2250 MEKLGLAIKESDAMST----QDQHVLFGKFAQ----IIQEKEVEI-----------DQLN 2290
Query: 749 PQHMEDQSRKDFEEEDVILQPEKNDSFQNVQPDEPKVLN--ECLSVQENNKANKLNQVPI 806
Q + Q + ++ +++ EKN+ ++++ +++ EC+ + +LN+V
Sbjct: 2291 EQVTKLQQQLKITTDNKVIE-EKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVI- 2348
Query: 807 LRTRFQKPKPNIGRGTGRREISSKEEVLE-KILVSGEMAAALRETVRLDTSPKEMVPAEI 865
+ Q+ NIG+ T S EE K + +A L +++T+ +EM +
Sbjct: 2349 --EKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKN 2406
Query: 866 NTKEMQSDLKETGRRAISPR------EKILDVIDDTIEM-----------------ETGL 902
KE + + + S + EKI + ++++ + E L
Sbjct: 2407 VLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDAL 2466
Query: 903 KAM--------------GREICLREKTPEVIDATEEIDKDLEEAGRREISPQKNGPEEVK 948
K++ G I L + ++ D +L + ++ Q+ G E +
Sbjct: 2467 KSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETE 2526
Query: 949 PLGEVETDLKATGNESSPREKTPEVT-DATEEIDKNLEETGRRKISPRENGPEEVKPV-- 1005
L + +L+ E ++ +A +E K ++ P + + +
Sbjct: 2527 MLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLRE 2586
Query: 1006 DEMETDLNATGRESSPREKTPEVIDATEEIDLEETEREVSPQENGLEEVKPLGEMETDLK 1065
DE+ +D++A S E +V++ + LE+ + E++ ++N LE+ K L E++ L+
Sbjct: 2587 DELGSDISALTLRISELES--QVVEMHTSLILEKEQVEIA-EKNVLEKEKKLLELQKLLE 2643
Query: 1066 ATGRDSFPRGKTPEVIDAIEEIEIDLEETEREISPQENGLEEVKPLGEMQTDLKATGREI 1125
G + R K E + +++E+ TE S +E+G L ++ + AT E+
Sbjct: 2644 --GNEKKQREK--EKKRSPQDVEVLKTTTELFHSNEESGF--FNELEALRAESVATKAEL 2697
Query: 1126 SPREKTPEVIDATEEIDKDLEETGRREISPEENGPEEVKP-VDEMETDLKTTGREGSSRE 1184
+ ++ E + + + + ++++S + E K + +E + +T +E
Sbjct: 2698 ASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKAC 2757
Query: 1185 KTREV-IDAAEVIETDLEETEREISPQENGPEEVKPVG-----KMETDLKEIREEISQ-- 1236
+ I ++ I + + T + S + VK G + E +E+ E ISQ
Sbjct: 2758 MFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFT 2817
Query: 1237 ------REKVLAEFSAIREKEIDLKETGKRD----IPIMEKVSGKMAVV----------- 1275
+E AE + + I ET KR+ + ++++ G + V
Sbjct: 2818 EKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSS 2877
Query: 1276 --EEMEADLKETGKENFRERGSE---EICVTEEKVAELKQTGK-------TDISPRE--- 1320
E +D +T + + GS+ I +T + ++ G+ TD P++
Sbjct: 2878 IPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKG 2937
Query: 1321 ------NE------LEETSTSRQTDTHLMQSGSNDFSAVPSLDIQNISSEVLSMMHTPVE 1368
NE L E+ S D H +Q S + I ISS L + T ++
Sbjct: 2938 LLRAVHNEGMQVLSLTESPYSDGED-HSIQQVSEPWLEERKAYINTISS--LKDLITKMQ 2994
Query: 1369 EKRNSEKEVSSHFSHFKISSQTHE------------------SDKTEVQGIQSPDVPEQF 1410
+R +E SS SH S E + +TE+ + + D
Sbjct: 2995 LQREAEVYDSSQ-SHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDA---- 3049
Query: 1411 SDINLSKSLPQ--EQKPLEIKPAPFVRSRFKR-----------PKPNLARAALKRETTES 1457
+ L L Q +++ +E + A + R + N + LKRE ES
Sbjct: 3050 --VGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQ-ES 3106
Query: 1458 EKYIYEKKSETKKMETIVMQENNEQTDTLPSQHDEASLMISREKDTLGHRNEEAVILPCT 1517
EK E + + M E + ++ + E +S EK + E
Sbjct: 3107 EKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELA----- 3161
Query: 1518 QTERNLSPSNSCEPK--EESQSAPVQKNDSVVSVGTNNVNTFQQEMKESVIQTARQVRGR 1575
QT+ L + + K +E ++ ++ D V N +T E K+S R+++
Sbjct: 3162 QTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLN-DTLASEQKKS-----RELQWA 3215
Query: 1576 LQRPRPNIRKTGQRQIVDKGEAKGIIKEGRT----ILPKDETEKKVLTVSNSQIETEIEV 1631
L++ + + ++ +R + + K ++ + + E +K++L S +IE++ +
Sbjct: 3216 LEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRML 3275
Query: 1632 PSSAVPEHRMYENQSQVVLV-ENLHVNKTNETIRHE---------------NKPYVPSSA 1675
+ + E + + QV+L E + + + + T+ E ++P +PS
Sbjct: 3276 YDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSED 3335
Query: 1676 QMT--RRKFQKAKPNLGRAHSKKEEPVLEKVTTDQ-------------------SKEGKP 1714
+ +++ ++ + ++ E+ L+ + T Q + EG+
Sbjct: 3336 LLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQK 3395
Query: 1715 EDHLLQKGASNTQLLLKEKAELLTSLEVSARKDCVGSKESALAKIDAELEEVGPSRRVGE 1774
+ H LQ + Q L+EK + + L++ ++ + K + E EE SRR+
Sbjct: 3396 KMHELQSKVEDLQRQLEEKRQQVYKLDLEGQR--LQGIMQEFQKQELEREEKRESRRILY 3453
Query: 1775 ETVGDNSPSSVVEEQYLN 1792
+ + + + S+ ++ N
Sbjct: 3454 QNLNEPTTWSLTSDRTRN 3471
Score = 45.4 bits (106), Expect = 7e-04
Identities = 169/929 (18%), Positives = 355/929 (38%), Gaps = 187/929 (20%)
Query: 1196 IETDLEETEREISPQENGPEEVKPVGKMETDLKEIREEISQREKVLAEFSAIREKEIDLK 1255
+E+++ T + S + NG V GK T+L +REE EF +
Sbjct: 103 LESEISTTADDCSSEVNGCSFVMRTGK-PTNL--LREE---------EFGV----DDSYS 146
Query: 1256 ETGKRDIP----IME-KVSGKMAVVEEMEADLKET----GKENFRERGSEEICVTEEKVA 1306
E G +D P +ME +++GK +EE+ +L+E G E ++ E + +
Sbjct: 147 EQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGI 206
Query: 1307 ELKQTGKTDISPREN--------ELEETSTSRQTDTHLMQSGS---NDFSAVPSLDIQNI 1355
+ T + RE EL E S Q +Q+ N + + D+
Sbjct: 207 ITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQA 266
Query: 1356 SSEVLSMMHTPVEE--------KRNSEKEVSSHFSHFKISSQTHESDKTEVQGIQSPDVP 1407
++L+ E+ K+ + + F KI E DK +V+ ++
Sbjct: 267 KQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDK-KVENSNKEEIQ 325
Query: 1408 EQ---FSDINLSKSLPQEQKPLEIKPAPFVRSRFKRPKPNLARAALKRETTESEKYIYEK 1464
E+ ++N +K + +E+K LE LK + T ++K + E
Sbjct: 326 EKETIIEELN-TKIIEEEKKTLE----------------------LKDKLTTADKLLGEL 362
Query: 1465 KSETKKMETIVMQENNEQTDTLPSQHDEASLMISREKDTLGHRNEEAVILPCTQTERNLS 1524
+ + ++Q+N E ++ + L S++K+ R I T L
Sbjct: 363 QEQ-------IVQKNQE------IKNMKLELTNSKQKE----RQSSEEIKQLMGTVEELQ 405
Query: 1525 PSNSCEPKEESQSAPVQKNDSVVSVGTNNVNTFQQEMKESVIQTARQVRGRLQRPRPNIR 1584
N + + E+ + ++ + + E+ E Q Q++ L R ++
Sbjct: 406 KRNHKDSQFETDIVQRMEQET-----QRKLEQLRAELDEMYGQQIVQMKQELIRQ--HMA 458
Query: 1585 KTGQRQIVDKGEAKGIIKEGRTILPKDETEKKVLTVSNSQIETEIEVPSSAVPEHRMYEN 1644
+ + + KGE + ++ I +E + K++ V+ +++ +++ +S + +
Sbjct: 459 QMEEMKTRHKGEMENALRSYSNITV-NEDQIKLMNVAINELNIKLQDTNS---QKEKLKE 514
Query: 1645 QSQVVLVENLHVNKTNETIRHENKPYVPSSAQMTRRKFQKAKPNLGRAHSKKEEPVLEKV 1704
+ ++L E + + E + E +R + Q+A+ + SK E
Sbjct: 515 ELGLILEEKCALQRQLEDLVEE--------LSFSREQIQRARQTIAEQESKLNEA----- 561
Query: 1705 TTDQSKEGKPEDHLLQKGASNTQLLLKEKAELLTSLEVSARKDCVGSKESALAKIDAELE 1764
K S + L KAE++++ E +RK+ E+ + +LE
Sbjct: 562 ---------------HKSLSTVEDL---KAEIVSASE--SRKELELKHEAEVTNYKIKLE 601
Query: 1765 EVGPSRRVGEETVGDNSPSSVVEEQYLNKLTSCPQPLNETSYSKIALDGKTTISSTSEYE 1824
+ + + + ++ +E L +L + +E SK+ D I E
Sbjct: 602 MLEKEKNAVLDRMAES------QEAELERLRTQLLFSHEEELSKLKED--LEIEHRINIE 653
Query: 1825 RNRGERRSHKKFKPNVTRGRGSKRVRGKTSKKEPRASKAMLVTLRASQEEDDDADDFESD 1884
+ + H K + + + S+++ +K+ +K + L S+ +D S
Sbjct: 654 KLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSK 713
Query: 1885 YEEESYHLAPEEVNKAPVFVPVGLRSPEPVSAQIEETMEELEITVNVPDVGCIAVVEHEL 1944
EE + ++N+ + + LR E +E+ ++EL++
Sbjct: 714 SEEMTL-----QINELQKEIEI-LRQEEKEKGTLEQEVQELQL----------------- 750
Query: 1945 PNTDVTTEEMKQEEN-LSVPFEMTTSEH--IQDEPGTNDGSTEAAITLLTMGDLVLQSEI 2001
T++ ++MK++EN L F +E+ ++DE T + L + + +
Sbjct: 751 -KTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDM------------LKIHTPV 797
Query: 2002 SSEQGDVGVCIIPHVHSKDKSHIPSS----LDNVNHKIVHECQELSSPVITT-SPASFEE 2056
S E+ + + + SK K + L N + +C +L+ + + SF E
Sbjct: 798 SQEER---LIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAE 854
Query: 2057 NKIVLEEQSSREEISLMEKVKENATPTRN 2085
+ Q +EE + + KVK++ ++N
Sbjct: 855 KNFEVNYQELQEEYACLLKVKDDLEDSKN 883
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 75.9 bits (185), Expect = 5e-13
Identities = 128/597 (21%), Positives = 227/597 (38%), Gaps = 65/597 (10%)
Query: 1000 EEVKPVDEMETDLNATGRESSPREKTPEVIDATEEIDLEETEREVSPQENGLEEVKPLGE 1059
E++K V++ E + ++ + T EV TEE + E E E +E G EE GE
Sbjct: 442 EKIKVVEKSEKETVIVEEQTEETQVTEEV---TEEEEKEAKEEEGKEEEGGEEEEAEGGE 498
Query: 1060 METDLKATGRDSFP--RGKTPEVIDAIEEIEIDLEETEREISPQENGLEEVKPLGEMQTD 1117
ET + P K+P +A E E E SP EVK + ++
Sbjct: 499 EETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSP-----AEVKSPEKAKSP 553
Query: 1118 LKATGREISPREKTPEVIDATEEIDKDLEETGRREISPEENGPEEVKPVDEMETDLKTTG 1177
K + P K+PE +A + E + E P E K ++ ++ +K
Sbjct: 554 AKEEAKS-PPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVK--- 609
Query: 1178 REGSSREKTREVIDAAEVIETDLEETEREISP---QENGPEEVKPVGKMETDLKE----- 1229
E S + + + +++ E+ SP + PE+ K K E E
Sbjct: 610 EEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSP 669
Query: 1230 IREEISQREKVLAEFSAIREKEIDLKETGKRDIPIMEKVSGKMAVVEEMEADLKETGK-- 1287
++ E EK + A + K K P+ E+ E+ ++ +KE K
Sbjct: 670 VKAEAKSPEKAKSPVKA------EAKSPEKAKSPVKEEAKSP----EKAKSPVKEEAKSP 719
Query: 1288 ENFRERGSEEICVTEEKVAELKQTGKTDISPRENELEET--STSRQTDTHLMQSGSNDFS 1345
E + EE E+ + +K+ K+ + E +T S + T + +
Sbjct: 720 EKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPAD 779
Query: 1346 AVPSLDIQNISSEVLS--MMHTPV-EEKRNSEKEVSSHFSHFKISSQTHESDKTEVQGIQ 1402
P + EV S +P+ E+ + EKE+ ++ S E +K + ++
Sbjct: 780 KFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIP---KKEEVKSPVKEEEKPQEVKVK 836
Query: 1403 SPDVPEQFSD--------INLSKSLPQEQKPLEIKPAPFVRSRFKRP---KPNLARAALK 1451
P P++ + K +E+ P + P P V + K P KP ++ K
Sbjct: 837 EP--PKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEK-KEPAVEKPKESKVEAK 893
Query: 1452 RETTESEKYI-YEKKSETKKMETIVMQENNEQTDTLPSQHDEASLMISREKDTLGHRNEE 1510
+E E +K + +K K+E + E+T+ + D+A ++E + E
Sbjct: 894 KEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAK---AKEPSKPAEKKEA 950
Query: 1511 AVILPCTQTERNLSPSNSCEPKEESQSAPVQKNDSVVSVGTNNVNTFQQEMKESVIQ 1567
A T+ E+ P +PK E A +++D +S + + E S Q
Sbjct: 951 APEKKDTKEEKAKKPEE--KPKTE---AKAKEDDKTLSKEPSKPKAEKAEKSSSTDQ 1002
Score = 72.4 bits (176), Expect = 6e-12
Identities = 123/597 (20%), Positives = 219/597 (36%), Gaps = 70/597 (11%)
Query: 907 REICLREKTPEVIDATEEIDKDLE-EAGRREISPQKNGPEEVKPLGEVETDLKATGNESS 965
+E + E+ E TEE+ ++ E EA E ++ G EE GE ET
Sbjct: 452 KETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEET---------- 501
Query: 966 PREKTPEVTDATEEIDKNLEETGRRKISPRENGPEEVKPVDEMETDLNATGR-------- 1017
K+P +A E+ + + P E K ++ E A +
Sbjct: 502 ---KSPPAEEAASP-----EKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSP 553
Query: 1018 -----ESSPREKTPEVIDATEEIDLEETEREVSPQENGLEEVKPLGEMETDLKATGRDSF 1072
+S P K+PE +A +++ E+ SP + EE K E ++ KA
Sbjct: 554 AKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAK---EEAKSPAEAKSPEKA------ 604
Query: 1073 PRGKTPEVIDAIEEIEIDLEETEREISPQENGLEEVKPLGEMQTDLKATGREISPRE--- 1129
K+P +A E E SP E E K + + K+ + SP +
Sbjct: 605 ---KSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPE-KAKSPTKEEAKSPEKAKSPEKEEA 660
Query: 1130 KTPEVIDATEEIDKDLEETGRREISPEENGPEEVK-PVDE----METDLKTTGREGSSRE 1184
K+PE + + + E + + E PE+ K PV E E E S E
Sbjct: 661 KSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPE 720
Query: 1185 KTREVIDAAEVIETDLEETEREISPQENGPEEVKPVGKMET-DLKEIREEISQREKVLAE 1243
K + + E +T E+ + + + PE+ K K +T D+K + +E+ +
Sbjct: 721 KAKSPV--KEEAKTP-EKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSP 777
Query: 1244 FSAIREKEIDLKETGKRDIPIMEKVSGKMAVVEEMEADLKE-TGKENFRERGSEEICVTE 1302
EK K K ++ EK K + E+ +A KE KE + EE E
Sbjct: 778 ADKFPEK---AKSPVKEEVKSPEK--AKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQE 832
Query: 1303 EKVAELKQTGKTDISPRENELEETSTSRQTDTHLMQSGSNDFSAVPSLDIQNISSEVLSM 1362
KV E + + + +P + EE S++ + ++ ++ +
Sbjct: 833 VKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEA 892
Query: 1363 MHTPVEEKRNSEKEVSSHFSHFKISSQTHESDKTEV-------QGIQSPDVPEQFSDINL 1415
E+K+ + ++ +KTEV + P P + +
Sbjct: 893 KKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAP 952
Query: 1416 SKSLPQEQKPLEIKPAPFVRSRFKRPKPNLARAALKRETTESEKYIYEKKSETKKME 1472
K +E+K + + P ++ K L++ K + ++EK + ++K E
Sbjct: 953 EKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPE 1009
Score = 71.2 bits (173), Expect = 1e-11
Identities = 123/598 (20%), Positives = 228/598 (38%), Gaps = 48/598 (8%)
Query: 1129 EKTPEVIDATEEIDKDLEETGRREISPEENGPEEVKPVDEMETDLKTTGREGSSREKTRE 1188
E+ E TEE+ ++ E+ + E EE G EE + E E +S EK +
Sbjct: 458 EEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAK 517
Query: 1189 ---VIDAAEVIETDLEETEREISPQE-NGPEEVKPVGKMET-DLKEIREEISQREKVLAE 1243
+A E E E SP E PE+ K K E E + + K AE
Sbjct: 518 SPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAE 577
Query: 1244 FSAIREKEIDLKETGKRDIPIMEKVSGKMAVVEEMEADLKETGKENFRERGSEEICVTEE 1303
+ + + KE K K V EE ++ + + E+ E+
Sbjct: 578 VKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEK 637
Query: 1304 KVAELKQTGKTDISPRENELEETSTSRQTDTHLMQSGSNDFSAVPSLDIQNISSEVLSMM 1363
+ K+ K+ + E EE + + + + + A + + S E
Sbjct: 638 AKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPE---KA 694
Query: 1364 HTPVEEKRNSEKEVSSHF-----SHFKISSQTHESDKTEVQGIQSPDVPEQFSDINLSKS 1418
+PV+E+ S ++ S S K S E KT + +SP V E+ +KS
Sbjct: 695 KSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTP-EKAKSP-VKEEAKSPEKAKS 752
Query: 1419 LPQEQKPLEIKPAPFVRSRFKRPKPNLARAALKRETTESEKYIYEKKSETKKMETIVMQE 1478
P++ K L++K K P AR+ + +++ + E+ +K ++ + ++
Sbjct: 753 -PEKAKTLDVK-----SPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKED 806
Query: 1479 NNEQTDTLPSQHDEASLMISREKDTLGHRNEEAVILPCTQTERNLSPSN-SCEPKEESQS 1537
+P + + S + EK E V P + E +P+ E K++S+
Sbjct: 807 AKAPEKEIPKKEEVKSPVKEEEKP-----QEVKVKEPPKKAEEEKAPATPKTEEKKDSKK 861
Query: 1538 APVQKNDSVVSVGTNNVNTFQQEMKESVIQTARQVRGRLQRPRPNIRKTGQRQIVDKGEA 1597
K ++ ++ KES ++ A++ ++ P K ++ K +A
Sbjct: 862 EEAPKKEAPKPKVEEKKEPAVEKPKESKVE-AKKEEAEDKKKVPTPEKEAPAKVEVKEDA 920
Query: 1598 KGIIKEGRTILPKDETE--KKVLTVSNSQIETEIEVPSSAVPEHRMYENQSQVVLVENLH 1655
K PK++TE KK + ++ ++ A PE + + + E
Sbjct: 921 K----------PKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEK-- 968
Query: 1656 VNKTNETIRHENKPYVPSSAQMTRRKFQKAKPNLGRAHSKKEEPVLEKVTTDQSKEGK 1713
KT + ++K S + ++ K +KA+ + + P EK T D++ +GK
Sbjct: 969 -PKTEAKAKEDDKTL---SKEPSKPKAEKAEKSSSTDQKDSKPP--EKATEDKAAKGK 1020
Score = 69.7 bits (169), Expect = 4e-11
Identities = 151/720 (20%), Positives = 271/720 (37%), Gaps = 81/720 (11%)
Query: 1029 IDATEEIDLEETEREVSPQENGLEEVKPLGEMETDLKA--TGRDSFPRGKTP-------- 1078
+D E T+ S QE E + L T+L+A + +DS R ++
Sbjct: 297 LDRLSEAAKVNTDAMRSAQEEITEYRRQLQARTTELEALKSTKDSLERQRSELEDRHQAD 356
Query: 1079 --EVIDAIEEIEIDLEETEREISPQENGLEEVKPLGEMQTDLK-ATGREISPREKT---- 1131
+AI++++ +L T+ E++ Q +++ + +M D++ A R++ E+
Sbjct: 357 IASYQEAIQQLDAELRNTKWEMAAQLREYQDLLNV-KMALDIEIAAYRKLLEGEECRIGF 415
Query: 1132 -PEVIDATEEIDKDLEETGRREISPEENGPEEVKPVDEMETDLKTTGREGSSREKTREVI 1190
P E + K + ++ EE ++K V++ E + E+T E
Sbjct: 416 GPIPFSLPEGLPKIPSVSTHIKVKSEE----KIKVVEKSEKETVIV------EEQTEETQ 465
Query: 1191 DAAEVIETDLEETEREISPQENGPEEVKPVGKMETDLKEIREEISQREK-----VLAEFS 1245
EV E + +E + E +E G EE + G E EE + EK V E
Sbjct: 466 VTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAK 525
Query: 1246 AIREKEIDLKETGKRDIPIMEKVSGKMAVVEEMEADLKETGKENFRERGSEEICVTEEKV 1305
+ E + KE K + K EE ++ + E + E+ E+
Sbjct: 526 SPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAK 585
Query: 1306 AELKQTGKTDISPRENELEETSTSRQTDTHLMQSGSNDFSAVPSLDIQNISSEVLS--MM 1363
+ K+ K SP E + E + S + ++ S + P + +EV S
Sbjct: 586 SPAKEEAK---SPAEAKSPEKAKSPVKE----EAKSPAEAKSPVKEEAKSPAEVKSPEKA 638
Query: 1364 HTPV-EEKRNSEKEVSSHFSHFKISSQTHESDKTEVQG---IQSPDVPEQFSDINLSKSL 1419
+P EE ++ EK S K + K E + +SP E S +
Sbjct: 639 KSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPV 698
Query: 1420 PQEQKPLEIKPAPFVRSRFKRPKPNLARAALKRETTESEKYIYEKKSETKKMETIVMQEN 1479
+E K E +P V+ K P+ A++ +K E EK K E K E ++
Sbjct: 699 KEEAKSPEKAKSP-VKEEAKSPEK--AKSPVKEEAKTPEKAKSPVKEEAKSPE---KAKS 752
Query: 1480 NEQTDTLPSQHDEASLMISREKDTLGHRNEEAVILPCTQTERNLSPSNSCEPKEESQSAP 1539
E+ TL + EA E + + E P + + SP + P +E AP
Sbjct: 753 PEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVK--SPEKAKSPLKEDAKAP 810
Query: 1540 ---VQKNDSVVSVGTNNVNTFQQEMKESVIQTARQVRGRLQRPRPNIRKTGQRQIVDKGE 1596
+ K + V S ++E K ++ + + P KT +++ K E
Sbjct: 811 EKEIPKKEEVKS-------PVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEE 863
Query: 1597 AKGIIKEGRTILPKDETEKKVLTVSNSQIETEIEVPSSAVPEHRMYENQSQVVLVENLHV 1656
A + PK + E+K E +E P + E + E + + +
Sbjct: 864 AP------KKEAPKPKVEEKK--------EPAVEKPKESKVEAKKEEAEDKKKVPTPEKE 909
Query: 1657 NKTNETIRHENKPYVPSSAQMTRRKFQKAKPNLGRAHSKKEEPVLEKVTTDQSKEGKPED 1716
++ + KP ++ +++ AK ++K+E EK T + K KPE+
Sbjct: 910 APAKVEVKEDAKP--KEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEE 967
Score = 65.9 bits (159), Expect = 5e-10
Identities = 128/630 (20%), Positives = 243/630 (38%), Gaps = 85/630 (13%)
Query: 424 RISDTERSQKDAQTVEEESLTLSREDAEQVALEVDLNQKKRRRKKQDGANELGVNNLLEN 483
+I E+S+K+ VEE+ T + E+V E + K+ K+++G E E
Sbjct: 443 KIKVVEKSEKETVIVEEQ--TEETQVTEEVTEEEEKEAKEEEGKEEEGGEE-------EE 493
Query: 484 ATVQAGPSKGEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGIVGFASTEKVEKRTDPI 543
A G + K +A PE + KE+ S + S EK E ++
Sbjct: 494 A---EGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAE-------AKSPEKEEAKSP-- 541
Query: 544 LSLSNQQDATSVATESSESSTSDLPSFEVGIRALCEVNNAEGSCIEERNVDLKNNSLEID 603
+ + + A S A E ++S + ++ EV + E + + + + E
Sbjct: 542 AEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKA--KSPAKEEAKSPAEAK 599
Query: 604 QTENVKPMLRGRFQRPKPNLSRAGKKSVLSQGKTESESKN---SHSKTSVEKNHVEKDKM 660
E K ++ + P K V + K+ +E K+ + S T E EK K
Sbjct: 600 SPEKAKSPVKEEAKSP-----AEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAK- 653
Query: 661 NTLDILRMETTERENPEAETVSVLGEKNCLQEGSQLKALRPVQVRG----RLQKPKPNAG 716
E E ++PE V E S KA PV+ + + P
Sbjct: 654 ------SPEKEEAKSPEKAKSPVKAEAK-----SPEKAKSPVKAEAKSPEKAKSPVKEEA 702
Query: 717 KAAERKEILISQEEIGANVEKNENESCADRDTPQHMEDQSRKDFEEEDVILQPEKNDSFQ 776
K+ E+ + + +E + EK ++ + TP+ + +++ + + PEK +
Sbjct: 703 KSPEKAKSPVKEE--AKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLD 760
Query: 777 NVQPDEPKVLNECLSVQENNKANKLNQVPILRTRFQKPKPNIGRGTGRREISSKEEVLEK 836
P+ E + + A+K + + + P + + + + E+ + K
Sbjct: 761 VKSPEAKTPAKE----EARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPK 816
Query: 837 ILVSGEMAAALRE-----TVRLDTSPK----EMVPAEINTKEMQSDLKETGRRAISPREK 887
E+ + ++E V++ PK E PA T+E + KE + +P+ K
Sbjct: 817 ---KEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPK 873
Query: 888 ILDVIDDTIE--METGLKAMGREICLREKTP---EVIDATEEIDKDLEEAGRREISPQKN 942
+ + + +E E+ ++A E ++K P + A E+ +D + + E++ K
Sbjct: 874 VEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVA--KK 931
Query: 943 GPEEVKPLGEVETDLKATGNESSPREKTPEVTDATEEIDKNLEETGRRKISPREN----G 998
P++ K K + +E PE D EE K EE + + +E+
Sbjct: 932 EPDDAK--------AKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLS 983
Query: 999 PEEVKP-VDEMETDLNATGRESSPREKTPE 1027
E KP ++ E + ++S P EK E
Sbjct: 984 KEPSKPKAEKAEKSSSTDQKDSKPPEKATE 1013
Score = 56.2 bits (134), Expect = 4e-07
Identities = 100/550 (18%), Positives = 193/550 (35%), Gaps = 61/550 (11%)
Query: 24 ASNPQRGRESPRPPDPATDSASKPAEPTDVPTVDFGGAEPQEKAPRSSTEKTGGD--NDV 81
A++P++ +SP + + + +K E + + + + K+P K+ + +
Sbjct: 509 AASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPE 568
Query: 82 EESSRSSSTVSQRRKRISSTSSLVKSSVSVPSESHPLSTINQEAPQPTATSTKEKQPCSD 141
+E ++S + V K S KS S S + +EA P + K+
Sbjct: 569 KEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKS 628
Query: 142 RYRIYKAQKLREMLKEELRKEKKQWKNKYAINESQRPPDRSKMTMRDFIYYLPDNNPMTS 201
+ +K + KEE + +K K E + P+++K ++
Sbjct: 629 PAEVKSPEKAKSPTKEEAKSPEKA---KSPEKEEAKSPEKAKSPVK-------------- 671
Query: 202 SLEQEKKTEKPSTPVQTREQEGKSTPNAEDNEMEEETDDGPLLVP---RVKVAEDGSIIL 258
+ K EK +PV+ E KS A+ EE P K E +
Sbjct: 672 --AEAKSPEKAKSPVKA---EAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPV 726
Query: 259 DEESLTVEVLRTKGPCVVEENDPIFERGSTTTYSSFRKNYYSKPWSNKETDMFFLAISMV 318
EE+ T E + K P E P + + K+ +K + +E
Sbjct: 727 KEEAKTPE--KAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEA---------- 774
Query: 319 GTDFSMIGQLFPHRARIEIKNKFKREEKTNGWRIDKAFQEKRPFDFDFFAHLLQKVLAEE 378
FP +A+ +K + K EK K P D A +K + ++
Sbjct: 775 ----RSPADKFPEKAKSPVKEEVKSPEKA-----------KSPLKED--AKAPEKEIPKK 817
Query: 379 EKRKQKSVKNHSLKEKKSTKPRKNVKVKKVACEGVNNDPDESMSSRISDTERSQKDAQTV 438
E+ K + +E K +P K + +K + +S E + +
Sbjct: 818 EEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEK 877
Query: 439 EEESLTLSREDAEQVALEVDLNQKKRRRKKQDGANELGVNNLLENATVQAGPSKGEKHKN 498
+E ++ +E + E ++KK +++ ++ V E+A + +K +
Sbjct: 878 KEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVK---EDAKPKEKTEVAKKEPD 934
Query: 499 KCQAIRPE--LKEGECSKEQMLSCTQNIDGIVGFASTEKVEKRTDPILSLSNQQDATSVA 556
+A P ++ E + E+ + + TE K D LS + A
Sbjct: 935 DAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKA 994
Query: 557 TESSESSTSD 566
+SS + D
Sbjct: 995 EKSSSTDQKD 1004
Score = 52.4 bits (124), Expect = 6e-06
Identities = 83/442 (18%), Positives = 158/442 (35%), Gaps = 81/442 (18%)
Query: 19 ARGSTASNPQRGRESPRPPDPATDSASKPAEPTDVPTVDFGGAEPQEKAPRSSTEKTGGD 78
A+ T + ++ P S K P A+ KA S EK
Sbjct: 638 AKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSP 697
Query: 79 NDVEESS--RSSSTVSQRRKRISSTSSLVKSSVSVPSESHPLSTINQEAPQPTATSTKEK 136
E S ++ S V + K S VK P ++ S + +EA P + EK
Sbjct: 698 VKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAK--SPVKEEAKSPEKAKSPEK 755
Query: 137 QPCSDRYRIYKAQKLREMLKEELRK--EKKQWKNKYAINESQRPPDRSKMTMRDFIYY-- 192
D K+ + + KEE R +K K K + E + P+++K +++
Sbjct: 756 AKTLD----VKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPE 811
Query: 193 --LPDNNPMTSSLEQEKKTEKPST---PVQTREQEGKSTPNAEDNEMEEETDDGPLLVPR 247
+P + S +++E+K ++ P + E++ +TP E+ + ++ + P+
Sbjct: 812 KEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPK 871
Query: 248 VKVAEDGSIILDEESLTVEVLRTKGPCVVEENDPIFERGSTTTYSSFRKNYYSK---PWS 304
KV E + +P E+ + + ++ K P
Sbjct: 872 PKVEE-------------------------KKEPAVEKPKESKVEAKKEEAEDKKKVPTP 906
Query: 305 NKETDMFFLAISMVGTDFSMIGQLFPHRARIEIKNKFKREEKTNGWRID----KAFQEKR 360
KE A++E+K K +EKT + + KA + +
Sbjct: 907 EKEAP-----------------------AKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSK 943
Query: 361 PFDFDFFAHLLQKVLAEEEKRKQKSVKNHSLKEKKSTKPRKNVKVKKVACEGVNNDPDES 420
P +K A EK+ K K +EK T+ + K ++ E +++
Sbjct: 944 P---------AEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKA 994
Query: 421 MSSRISDTERSQKDAQTVEEES 442
S +D + S+ + E+++
Sbjct: 995 EKSSSTDQKDSKPPEKATEDKA 1016
Score = 51.6 bits (122), Expect = 1e-05
Identities = 120/635 (18%), Positives = 206/635 (32%), Gaps = 110/635 (17%)
Query: 32 ESPRPPDPATDSASKPAEPTDVPTVDFGGAEPQEKAPRSSTEKTGGDNDVEESSRSSSTV 91
E + + T+ K A+ + + GG E + + T+ + + S V
Sbjct: 462 EETQVTEEVTEEEEKEAKEEEGKEEE-GGEEEEAEGGEEETKSPPAEEAASPEKEAKSPV 520
Query: 92 SQRRKRISSTSSLVKSSVSVPSE----SHPLSTINQEAPQPTATSTKEKQPCSDRYRIYK 147
+ K + S K P+E S +EA P + EK+ +
Sbjct: 521 KEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKS 580
Query: 148 AQKLREMLKEELR---KEKKQWKNKYAINESQRPPDRSKMTMRDFIYYLPDNNPMTSSLE 204
+K + KEE + + K K K + E + P +K +++ S
Sbjct: 581 PEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKE----------EAKSPA 630
Query: 205 QEKKTEKPSTPVQTREQEGKSTPNAEDNEMEEETDDGPLLVPRVKVAEDGSIILDEESLT 264
+ K EK +P ++E KS A+ E EE K E + E+ +
Sbjct: 631 EVKSPEKAKSPT---KEEAKSPEKAKSPEKEE-----------AKSPEKAKSPVKAEAKS 676
Query: 265 VEVLRTKGPCVVEENDPIFERGSTTTYSSFRKNYYSKPWSNKETDMFFLAISMVGTDFSM 324
E + K P E P E+ + + +K +E A S V +
Sbjct: 677 PE--KAKSPVKAEAKSP--EKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKT 732
Query: 325 IGQLFPHRARIEIKNKFKREEKTNGWRIDKAFQEKRPFDFDFFAHLLQKVLAEEEKRKQK 384
P +A+ +K + K EK K K P K A+EE R
Sbjct: 733 -----PEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSP---------EAKTPAKEEARSPA 778
Query: 385 SVKNHSLKEKKSTKPRKNVKVKKVACEGVNNDPDESMSSRISDTERSQKDAQTVEEESLT 444
EK + ++ VK P+++ S D + +K+ EE
Sbjct: 779 D----KFPEKAKSPVKEEVK-----------SPEKAKSPLKEDAKAPEKEIPKKEEVKSP 823
Query: 445 LSREDAEQVALEVDLNQKKRRRKKQDGANELGVNNLLENATVQAGPSKGEKHKNKCQAIR 504
+ E+ Q EV + + ++ E A P EK +K
Sbjct: 824 VKEEEKPQ---EVKVKEPPKK---------------AEEEKAPATPKTEEKKDSK----- 860
Query: 505 PELKEGECSKEQMLSCTQNIDGIVGFASTEKVEKRTDPILSLSNQQDATSVATESSESST 564
KE KE A KVE++ +P + + + E+ +
Sbjct: 861 ---KEEAPKKE---------------APKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKK 902
Query: 565 SDLPSFEVGIRALCEVNNAEGSCIEERNVDLKNNSLEIDQTENVKPMLRGRFQRPKPNLS 624
P E A +V E + +E+ K + E KP + K +
Sbjct: 903 VPTPEKE----APAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTK 958
Query: 625 RAGKKSVLSQGKTESESKNSHSKTSVEKNHVEKDK 659
K + KTE+++K S E + + +K
Sbjct: 959 EEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEK 993
Score = 33.9 bits (76), Expect = 2.2
Identities = 97/522 (18%), Positives = 182/522 (34%), Gaps = 34/522 (6%)
Query: 1419 LPQEQKPLEIKPAPFVRSRFKRPKPNLARAALKRETTESEKYIYEKKSETKKMETIVMQE 1478
+P +++K ++ K K + ET +E+ E++ E K+ E +E
Sbjct: 429 IPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEG-KEEE 487
Query: 1479 NNEQTDTLPSQHDE----ASLMISREKDTLGHRNEEA---VILPCTQTERNLSPSNSCEP 1531
E+ + + + A S EK+ EEA + E SP+ P
Sbjct: 488 GGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSP 547
Query: 1532 -------KEESQSAPVQKNDSVVSVGTNNVNTFQQEMKESVIQTARQVRGRLQRPRPNIR 1584
KEE++S P K+ + ++ K + A+ + P
Sbjct: 548 EKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPA---EAKSPEKA 604
Query: 1585 KTG-QRQIVDKGEAKGIIKEGRTILPKDETEKKVLTVSNSQIETEIEVPSSAVPEHRMYE 1643
K+ + + EAK +KE + ++ +K + + + ++ + S E + E
Sbjct: 605 KSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPE 664
Query: 1644 NQSQVVLVENLHVNKTNETIRHENKPYVPSSAQMTRRKFQKAKPNLGRAHSKKEEPVLEK 1703
V E K ++ E K P A+ ++ K+ P ++ K+E EK
Sbjct: 665 KAKSPVKAEAKSPEKAKSPVKAEAKS--PEKAKSPVKEEAKS-PEKAKSPVKEEAKSPEK 721
Query: 1704 VTTDQSKEGKPEDHLLQKGASNTQLLLKEKA-ELLTSLEVSARKDCVGSKESALAKIDAE 1762
+ +E K + + K K+ E +L+V + + +KE A + D
Sbjct: 722 AKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKF 781
Query: 1763 LEEVGPSRRVGEETVGDNSPSSVVEEQYLNKLTSCPQPLNETSYSKIALDGKTTISSTSE 1822
E+ V EE S ++E K P E S + + K E
Sbjct: 782 PEKA--KSPVKEEVKSPEKAKSPLKEDA--KAPEKEIPKKEEVKSPVKEEEKPQEVKVKE 837
Query: 1823 YERNRGERRSHKKFKPNVTRGRGSKRVRGKTS-------KKEPRASKAMLVTLRASQEED 1875
+ E ++ K + + K + KKEP K + A +EE
Sbjct: 838 PPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEA 897
Query: 1876 DDADDFESDYEEESYHLAPEEVNKAPVFVPVGLRSPEPVSAQ 1917
+D + +E + +E K V + P+ A+
Sbjct: 898 EDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAK 939
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 75.5 bits (184), Expect = 7e-13
Identities = 186/972 (19%), Positives = 383/972 (39%), Gaps = 144/972 (14%)
Query: 1022 REKTPEVIDATEEIDLEET-EREVSPQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEV 1080
RE T E D +EE++ T E +V QE L ++ + KA G+T +
Sbjct: 1418 REMTKEERDMSEEVEEMATLEEKVVKQEGKLVMIERTPSWQDWKKAWDEWKQVHGETRKS 1477
Query: 1081 IDAIEEI--------EIDLEETEREISPQENGLEEVKPLGEMQTDLKATGREISPREKTP 1132
A +E E L + ++SP+E L+E K L + + + +S + K
Sbjct: 1478 WKAWKEEWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKKL-KWEEWKQVWENMLSSKSKEQ 1536
Query: 1133 EVIDATEEIDKDLEETGRREISPEENGPEEVKPVDEMETDLKTTGREGSSREKTREVIDA 1192
+ D EE+ + EE R E+ EE + + E E R+ + EK R
Sbjct: 1537 QYKDE-EEVTLE-EEVSREGEEKEQQVTEEQRHIQE-EHKWARIHRKRARAEKKRA---- 1589
Query: 1193 AEVIETDLEETEREISPQENG-PEEVKPVGKMETDLKEIREEISQREKVLAEFSA-IREK 1250
+ ER+++ +E +E + + + E L + +I+Q ++ +A+ +K
Sbjct: 1590 ---------QEERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQK 1640
Query: 1251 EIDLKETGKRDIPIMEKVSGKMA-VVEEMEADLKETGKENFRERG---SEEICVTEEKVA 1306
E L + G++ EK++ K + ++ E +E +E ++G +E + +KV
Sbjct: 1641 EETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVARE--EEKLAKKGGKLAEVKNILAQKVE 1698
Query: 1307 ELKQTGKTDISPRENELEETSTSRQTDTHLMQSGSNDFSAVPSLDIQNISSEVLSMMHTP 1366
EL Q + ++ +E EL + + D + S + ++ E ++
Sbjct: 1699 ELPQR-EQNLDWQEKELAQELEELEWDMEEL-----------SWKEEELNQEEGKLVE-- 1744
Query: 1367 VEEKRNSEKEVSSHFSHFKISSQTHESDKTEVQGIQSPDVPEQFSDINLSKSLPQEQKPL 1426
E+K+ +E+E + + K+S + + + E IQ + Q + +P+E++ L
Sbjct: 1745 -EKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKE-----KMPEEEERL 1798
Query: 1427 EIKPAPFVRSRFKRPKPNLARAALKRETTESEKYIY-------EKKSETKKMETIVMQEN 1479
K + + K + E T+++ +Y EKK+ ++ E + ++
Sbjct: 1799 GRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKE 1858
Query: 1480 NEQTDTLPSQHDEASLMISREKDTLGHRNEEAVILPCTQTERNLSPSNSCEPKEESQSAP 1539
N + H + L+ + K+ LG N+ + T+ + E E++
Sbjct: 1859 NLLYNKERLTHSKKQLV--QVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKL 1916
Query: 1540 VQKNDSVVSVGTNNVNTFQQEMK----ESVIQTARQVRGRLQRPRPNIRKTGQRQIVDKG 1595
VQ DS+ Q++MK ++++Q +++RG L + K ++
Sbjct: 1917 VQVEDSLAK---KQEKLAQEKMKLALEKAMVQGKKRLRGELDIAKEE--KALNLEMKRLA 1971
Query: 1596 EAKGIIKEGRTILPKDETEKKVLTVSNSQIETEIEVPSSAVPEHRMYENQSQVVLVENLH 1655
E K + EG+ L K ET + +Q+E E+ ++ E ++ ++ +++ +E
Sbjct: 1972 EEKMRLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSL-EEKILLHEDRILAMEESE 2030
Query: 1656 VNKTNETIRHENKPYVPSSAQMTR--RKFQKAKPNLGRAHSKKEE--PVLEKVTTDQSKE 1711
+ K + +V ++ + RK K + +L + +K + L+K+T D+ K
Sbjct: 2031 IAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKL 2090
Query: 1712 GKPEDHLLQKGASNTQLLLKEKAELLTSLEVSARKDCVGSKESALAKIDAEL-------- 1763
+ E ++ L +KE+ + ++ ++ K S L K + +L
Sbjct: 2091 TQEE---IKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLA 2147
Query: 1764 ---------------EEVGPSRRVGEETVGDNSPSSVVEEQYLNKL-------------- 1794
EE +R+ E + D + EE+ + L
Sbjct: 2148 NKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGD 2207
Query: 1795 -------TSCPQPLNETSYSKIA------LDGKTTISSTSEYERNRGERRSHKKFKPN-- 1839
+ + +E +S+ L+ + ++SS E ER E R ++ +
Sbjct: 2208 KPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEE 2267
Query: 1840 ------------VTRGRGSKRVRGKTSKKEPRASKAMLVTLRASQEEDDDADDFESDYEE 1887
V + K+ + K KKE K + + +++ + + EE
Sbjct: 2268 ERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEE 2327
Query: 1888 ESYHLAPEEVNK 1899
E EEV++
Sbjct: 2328 EESCSLEEEVDR 2339
Score = 72.8 bits (177), Expect = 4e-12
Identities = 206/1137 (18%), Positives = 436/1137 (38%), Gaps = 197/1137 (17%)
Query: 824 RREISSKEEVLEKILVSGEMAAALRETVRLDTSPKEMVPAEINTKEMQSDLKETGRRAIS 883
++ I +E + + ++ G +R KE++P E E Q+ K +
Sbjct: 1314 KKPIFIQEGAIREDMIQGVTQEVIRH--------KEVMPRE----EEQAQKKARDMLGLE 1361
Query: 884 PREKILDVIDDTIEMETGLKAMGREICLRE------KTPEVIDATEEIDKDLEEAGRREI 937
+ IL I +E G MG+EI +E K+P+ + ++ + + R
Sbjct: 1362 ETQVILKKGKKVIFLEPGNVTMGKEISKKEEKKTFQKSPKQGRKAVQKERKVGKIKREMT 1421
Query: 938 SPQKNGPEEVKPLGEVETDLKATGNESSPREKTPEVTDATEEIDKNLEETGRRKISPREN 997
+++ EEV+ + +E + + E+TP D + D+ + G + S +
Sbjct: 1422 KEERDMSEEVEEMATLEEKVVKQEGKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAW 1481
Query: 998 GPEEVKPVDEMETDLNATGRESSPREKTPEVIDATEEIDLEETEREVSPQENGLEEVKPL 1057
E K + + E L+ G + SP E E++ +++ EE ++ EN L
Sbjct: 1482 KEEWEKRLLQEEEKLHQAGEKLSPEE---EMLQEDKKLKWEEWKQ---VWENML------ 1529
Query: 1058 GEMETDLKATGRDSFPRGKTPEVIDAIEEIEIDLEETEREISPQENGLEEVKPLGEMQTD 1117
+ + + K E + EE+ + EE E++++ ++ ++E +
Sbjct: 1530 ---------SSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRK 1580
Query: 1118 LKATGREISPREKTPEVIDATEEIDKDLEETGRREISPEENGPEEVKPVDEMETDLKTTG 1177
R + +++ E +E +K +E R+++ EE + V + D +
Sbjct: 1581 -----RARAEKKRAQEERKLAQEEEKLAQE--ERQLAQEERKLAQAY-VKITQDDREMAQ 1632
Query: 1178 REGSSREKTREVIDAAEVIETDLEETEREISPQENGPEEVKPVGKMETDLKEIREEISQR 1237
EG +K + E + + E+ ++ K + K + E+++++
Sbjct: 1633 AEGKFAQKEETLAQRGEKLSQEAEKL----------AQKRKKLAKKWEKVAREEEKLAKK 1682
Query: 1238 EKVLAEFSAIREKEIDLKETGKRDIPIMEKVSGKMAVVEEMEADLKETGKENFRERGSEE 1297
LAE I ++++ ++++ EK + +EE+E D++E + E EE
Sbjct: 1683 GGKLAEVKNILAQKVEELPQREQNLDWQEKELAQ--ELEELEWDMEELSWKE-EELNQEE 1739
Query: 1298 ICVTEEKVAELKQTGKTDISPRENELEETSTSRQTDTHLMQSGSNDFSAVPSLDIQNISS 1357
+ EEK +L + + RE EE + Q + L+Q + + ++
Sbjct: 1740 GKLVEEK-KKLAEEEEALAWQREKLSEEETKLAQEEELLIQ------------EKEKLAQ 1786
Query: 1358 EVLSMMHTPVEEKRNSEKEVSSHFSHFKISSQTHESDKTEVQGIQSPDVPEQFSDINLSK 1417
M P EE+R K I + + K E ++ + + K
Sbjct: 1787 HKEKM---PEEEERLGRKREQ------LIEKKMKLAQKRERWINSMEELTKNKMILYQKK 1837
Query: 1418 SLPQEQKPLEIKPAPFVRSRFKRPKPNLARAALKRETTESEKYIYEKKSETKKMETIVMQ 1477
+L QE+K L + + + + K NL K T S+K + + K++ I+ Q
Sbjct: 1838 NLAQEKKNLAQE-----KEKLAQRKENLLYN--KERLTHSKKQLVQVKNKLGMFNKILAQ 1890
Query: 1478 ENNEQTDTLPSQHDEASLMISREKDTLGHRNEEAVILPCTQTERNLSPSNSCEPKEESQS 1537
+ +++EK+T+ + E+ +TE+ L
Sbjct: 1891 VEEK---------------LTQEKETVIKKKEK-----LAETEKKL-------------- 1916
Query: 1538 APVQKNDSVVSVGTNNVNTFQQEMK----ESVIQTARQVRGRLQRPRPNIRKTGQRQIVD 1593
VQ DS+ Q++MK ++++Q +++RG L + K ++
Sbjct: 1917 --VQVEDSLAK---KQEKLAQEKMKLALEKAMVQGKKRLRGELDIAKE--EKALNLEMKR 1969
Query: 1594 KGEAKGIIKEGRTILPKDETEKKVLTVSNSQIETEIEVPSSAVPEHRMYENQSQVVLVEN 1653
E K + EG+ L K ET + +Q+E E+ ++ E ++ ++ +++ +E
Sbjct: 1970 LAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSL-EEKILLHEDRILAMEE 2028
Query: 1654 LHVNKTNETIRHENKPYVPSSAQMTR--RKFQKAKPNLGRAHSK--KEEPVLEKVTTDQS 1709
+ K + +V ++ + RK K + +L + +K K L+K+T D+
Sbjct: 2029 SEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDER 2088
Query: 1710 KEGKPEDHLLQKGASNTQLLLKEKAELLTSLEVSARKDCVGSKESALAKIDAEL------ 1763
K + E ++ L +KE+ + ++ ++ K S L K + +L
Sbjct: 2089 KLTQEE---IKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRK 2145
Query: 1764 -----------------EEVGPSRRVGEETVGDNSPSSVVEEQYLNKL------------ 1794
EE +R+ E + D + EE+ + L
Sbjct: 2146 LANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKR 2205
Query: 1795 ---------TSCPQPLNETSYSK------IALDGKTTISSTSEYERNRGERRSHKKFKPN 1839
+ + +E +S+ L+ + ++SS E ER E R ++ +
Sbjct: 2206 GDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREE 2265
Query: 1840 VTRGRGSKRVRGKTSKKEPRASKAMLVTLRASQEEDDDADDFESDYEEESYHLAPEE 1896
+ + K +KE K + +++ ++ + E +EE+ ++ EE
Sbjct: 2266 EEERKEEEEGEEKQVEKEEEEKKK-----KKKEKKKEEVQEKEEVFEEKEEIMSEEE 2317
Score = 65.9 bits (159), Expect = 5e-10
Identities = 159/780 (20%), Positives = 307/780 (39%), Gaps = 93/780 (11%)
Query: 624 SRAGKKSVLSQGKTESESKNSHSKTSVEKNHVEKDKMNTLDILRMETTERENPEAETVSV 683
+RA KK + K E + + E+ ++++ +++ +RE +AE
Sbjct: 1582 ARAEKKRAQEERKLAQEEEKLAQE---ERQLAQEERKLAQAYVKITQDDREMAQAEGKFA 1638
Query: 684 LGEKNCLQEGSQL--KALRPVQVRGRL-----------QKPKPNAGKAAERKEILISQEE 730
E+ Q G +L +A + Q R +L +K GK AE K IL + E
Sbjct: 1639 QKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVE 1698
Query: 731 IGANVEKNENESCADRDTPQHME----DQSRKDFEEEDVILQPEKNDSFQNVQPDEPKVL 786
++ +N +++ Q +E D ++EE++ + K + +E + L
Sbjct: 1699 --ELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEAL 1756
Query: 787 ---NECLSVQENNKANK---LNQVPILRTRFQKPKPNIGRGTGRREISSKEEVLEKILVS 840
E LS +E A + L Q + ++ P GR+ +E+++EK +
Sbjct: 1757 AWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRK----REQLIEKKMKL 1812
Query: 841 GEMAAALRETVRLDTSPKEMVPAEINTKEMQSDLKETGRRAISPREKILDVIDDTIEMET 900
+ ++ T K ++ + N + + +L + + +E +L + +
Sbjct: 1813 AQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKK 1872
Query: 901 GLKAMGREICLREKTPEVIDATEEIDKDLEEAGRREISPQKNGPEEVKPLGEVETDLKAT 960
L + ++ + K ++++ L + I ++ E K L +VE L
Sbjct: 1873 QLVQVKNKLGMFNKI------LAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKK 1926
Query: 961 GNESSPREKTPEVTDATEEIDKNLEETGRRKISPRENGPE-EVKPVDEMETDLNATGRES 1019
+ + + + A + K L G I+ E E+K + E + L G+E+
Sbjct: 1927 QEKLAQEKMKLALEKAMVQGKKRLR--GELDIAKEEKALNLEMKRLAEEKMRL-VEGKET 1983
Query: 1020 SPREKTPEVIDATE--EIDLEETEREVSPQENGLEEVKPLGEMETDLKATGRDSFPRG-- 1075
+ +TPE + +++ E ER++S +E L + ME A G+ F RG
Sbjct: 1984 LSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQR 2043
Query: 1076 ------------------------KTPEVIDAIEEIEIDLEETEREISPQENGLEEVKP- 1110
K P ++ I + L ER+++ +E + ++K
Sbjct: 2044 IFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRA 2103
Query: 1111 --LGEMQTDLKATGREISP---REKTPEVIDATEEI---DKDLEETGRREISPEENGPEE 1162
+ E + ++ + +I EK E+ +++ + L RR I+ EE EE
Sbjct: 2104 LFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEE 2163
Query: 1163 VKPVDEMETDLKTTGREGSSREKTREVIDAAEVIETDLEETEREISPQENGPEEVKPVG- 1221
+ +++ E E+ EVI + +E +R P+E +V V
Sbjct: 2164 ESKLARKHSEVILDDEEEGGIEE-EEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVES 2222
Query: 1222 ------KMETDLKEI--REEISQREKVLAEFSAIREKEIDLKETGKRDIPIMEKVSGKMA 1273
+ME+ L E+ +E +S E+ E RE+E +E +R E+ G+
Sbjct: 2223 EEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEER----KEEEEGEEK 2278
Query: 1274 VVEEMEADLKETGKENFRERGSEEICVTEEKVAELKQTGKTDISPRENELEETSTSRQTD 1333
VE+ E + K+ KE +E E+ V EEK + + +S E E E S + D
Sbjct: 2279 QVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEEEVD 2338
Score = 52.8 bits (125), Expect = 5e-06
Identities = 231/1196 (19%), Positives = 446/1196 (37%), Gaps = 177/1196 (14%)
Query: 152 REMLKEELRKEKKQWKNKYAINESQRPPDRSKMTMRDFIYYLPDNNPMTSSLEQEKKTEK 211
+E++ E + +K+ ++ + E+Q + K I+ P N +T E KK EK
Sbjct: 1340 KEVMPREEEQAQKKARDMLGLEETQVILKKGKKV----IFLEPGN--VTMGKEISKKEEK 1393
Query: 212 PSTPVQTREQEGKSTPNAEDNEMEEETDDGPLLVPRVKVAEDGSIILDE-ESLTVEVLRT 270
+ + +P +++E G + K D S ++E +L +V++
Sbjct: 1394 KTF---------QKSPKQGRKAVQKERKVGKIKREMTKEERDMSEEVEEMATLEEKVVKQ 1444
Query: 271 KGPCVVEENDPIFERGSTT------TYSSFRKNYYSKPWSNKETDMFFLAISMVGTDFSM 324
+G V+ E P ++ + RK++ K W + + +
Sbjct: 1445 EGKLVMIERTPSWQDWKKAWDEWKQVHGETRKSW--KAWKEE----WEKRLLQEEEKLHQ 1498
Query: 325 IGQ-LFPHRARIEIKNKFKREEKTNGWRIDKAFQEKRPFDFDFFAHLLQKVLAEEEKRKQ 383
G+ L P ++ K K EE W + + K D L++ ++ E + K+
Sbjct: 1499 AGEKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKE 1558
Query: 384 KSV---KNHSLKEKKSTK-PRKNVKVKKVACEGVNNDPDESMSSRISDTERSQKDAQTVE 439
+ V + H +E K + RK + +K R + + ++ + +
Sbjct: 1559 QQVTEEQRHIQEEHKWARIHRKRARAEK---------------KRAQEERKLAQEEEKLA 1603
Query: 440 EESLTLSREDAEQVALEVDLNQKKRRRKKQDGANELGVNNLLENATV--QAGPSKGEKHK 497
+E L++E+ + V + Q R + +G L + Q +K K
Sbjct: 1604 QEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRK 1663
Query: 498 NKCQAIRPELKEGE--CSKEQMLSCTQNIDGIVGFASTEKVEKRTDPILSLSNQQDATSV 555
+ +E E K L+ +NI +KVE+ +L Q+ +
Sbjct: 1664 KLAKKWEKVAREEEKLAKKGGKLAEVKNI-------LAQKVEELPQREQNLDWQEKELAQ 1716
Query: 556 ATESSESSTSDLPSFEVGIRALCEVNNAEGSCIEERNVDLKNNSLEIDQTENVKPMLRGR 615
E E +L E E+N EG +EE+ ++ + E R +
Sbjct: 1717 ELEELEWDMEELSWKEE------ELNQEEGKLVEEKK--------KLAEEEEALAWQREK 1762
Query: 616 FQRPKPNLSRAGKKSVLSQGKTESESKNSHSKTSVEKNHVEKDKMNTLDILRMETTEREN 675
+ L++ ++ +L Q E E H + E+ K L +M+ ++
Sbjct: 1763 LSEEETKLAQ--EEELLIQ---EKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRE 1817
Query: 676 PEAETVSVLGEKNCLQEGSQLKALRPVQVRGRLQKPKPNAGKAAERKEILISQEEIGANV 735
++ L + + Q K L Q + L + K K A+RKE L+ +E +
Sbjct: 1818 RWINSMEELTKNKMILY--QKKNL--AQEKKNLAQEKE---KLAQRKENLLYNKERLTHS 1870
Query: 736 EKN----ENESCADRDTPQHMEDQSRKDFEEEDVILQPEKNDSFQNVQPDEPKVLN--EC 789
+K +N+ +E++ + E+E VI + EK + E K++ +
Sbjct: 1871 KKQLVQVKNKLGMFNKILAQVEEKLTQ--EKETVIKKKEK------LAETEKKLVQVEDS 1922
Query: 790 LSVQENNKANKLNQVPILRTRFQKPKPNIGRGTGRREISSKEEVLEKILVSGEMAAALRE 849
L+ ++ A + ++ + + Q K R G +I+ +E+ L EM E
Sbjct: 1923 LAKKQEKLAQEKMKLALEKAMVQGKK----RLRGELDIAKEEKALNL-----EMKRLAEE 1973
Query: 850 TVRL----DTSPKEMVPAEINTKEMQSDLKETGRRAISPREKILDVIDDTIEMETGLKAM 905
+RL +T K P ++M +E R +S EKIL D + ME A
Sbjct: 1974 KMRLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAK 2033
Query: 906 G----------------------------REICLRE--KTPEVIDATEEIDKDLEEAGRR 935
G RE +E K +++ A +++ +D + +
Sbjct: 2034 GKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQE 2093
Query: 936 EISPQKNG-----PEEVKPLGEVETDLKATGNESSPREKTPEVTDATEEI---DKNLEET 987
EI K E + + + D+K E EK E+T +++ + L
Sbjct: 2094 EIKMTKMKRALFVKERRLSIEQSKLDIK----EWDFSEKRSELTKDEKKLARKQRKLANK 2149
Query: 988 GRRKISPRENGPEEVKPVDEMETDLNATGRESSPREKTPEVIDATEEI--DLEETEREVS 1045
RR I+ E EE + +++ E E+ EVI + +E +R
Sbjct: 2150 MRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEEE-EVIPFLKRRWRKRKEAKRGDK 2208
Query: 1046 PQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEVIDAIEEIEIDLEET--EREISPQEN 1103
P+E +V + E E + E + + EE E + EE E E+ +E
Sbjct: 2209 PKEKFSSQVDEV-ESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEE 2267
Query: 1104 GLEEVKPLGEMQTDLKATGREISPREKTPEVIDATEEIDKDLEETGRRE----ISPEENG 1159
+E + E Q + + ++ +EK E + EE+ ++ EE E +S EE
Sbjct: 2268 ERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEE 2327
Query: 1160 PEEVKPVDEMETDLKTTGREGSSR--EKTREVIDAAEVIETDLEETEREISPQENGPEEV 1217
E +E++ + + +E + E+ R+ + E + + L +G
Sbjct: 2328 EESCSLEEEVDREKEILKKEKQFKLQEQRRKSLRGRERVLSILRGV-------PHGKGRA 2380
Query: 1218 KPVGKMETDLKEIRE-EISQREKVLAEFSAIREKEIDLKETGKRDIPIMEKVSGKM 1272
+G +++ LK++ + +EK + EK+I ++ + I K G M
Sbjct: 2381 IRLGVLKSPLKKLMSTALEMKEKTPV---PVPEKQISWEDKKATVVEIPRKFLGTM 2433
Score = 38.9 bits (89), Expect = 0.068
Identities = 117/629 (18%), Positives = 232/629 (36%), Gaps = 73/629 (11%)
Query: 61 AEPQEKAPRSSTEKTGGDNDVEESSRSSSTVSQRRKR-ISSTSSLVKSSVSVPSESHPLS 119
A+ +EK P E+ G E+ ++Q+R+R I+S L K+ + + +
Sbjct: 1785 AQHKEKMPEEE-ERLGRKR--EQLIEKKMKLAQKRERWINSMEELTKNKMILYQKK---- 1837
Query: 120 TINQEAPQPTATSTKEKQPCSDRYRIYKAQKLREMLKEELRKEKKQWKNKYAINESQRPP 179
N + KEK +Y ++L +K+ Q KNK +
Sbjct: 1838 --NLAQEKKNLAQEKEKLAQRKENLLYNKERLTHS-----KKQLVQVKNKLGMFNKILAQ 1890
Query: 180 DRSKMTMRDFIYYLPDNNPMTSSLEQEKKTEKPSTPVQTREQEGKSTPNAEDNEMEEETD 239
K+T T ++EK E VQ + K +M+ +
Sbjct: 1891 VEEKLTQEK----------ETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALE 1940
Query: 240 DGPLLVPRVKVAEDGSIILDEESLTVEVLRTKGPCVVEENDPIFERGSTTTYSSFRKNYY 299
++ + ++ + I +E++L +E+ R + EE + E T + +
Sbjct: 1941 KA-MVQGKKRLRGELDIAKEEKALNLEMKR-----LAEEKMRLVEGKETLSKGETPETSR 1994
Query: 300 SKPWSNKETDMFFLAISM-----------VGTDFSMI--GQL-FPHRARIEIKNKFKREE 345
+ + E ++F +S+ + + S I G+L F RI ++ + K +
Sbjct: 1995 QRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKLAK 2054
Query: 346 KTNGWRIDKAFQEKRPFDFDFFAHLLQKVLAEEEKRKQKSVKNHSLKEKKSTKPRKNVKV 405
+ + K P + LQK+ +E K Q+ +K +K K R+ + +
Sbjct: 2055 ASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERR-LSI 2113
Query: 406 KKVACEGVNNDPDESMSSRISDTER-SQKDAQTVEEESLTLSREDAEQVALEVDLNQKKR 464
++ + D E S D ++ ++K + + +++E E++ E +K
Sbjct: 2114 EQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKE--EKMTEEESKLARKH 2171
Query: 465 RRKKQDGANELGVNNLLENATVQAGPSKGEKHKNKCQAIRPELKEGECSKEQMLSCTQNI 524
D E G+ E + + K K E K G+ KE+ S +
Sbjct: 2172 SEVILDDEEEGGIE---EEEVIPFLKRRWRKRK--------EAKRGDKPKEKFSSQVDEV 2220
Query: 525 DGIVGFASTEKVEKRTDPILSLSNQQDATSVATESSESSTSDLPSFEVGIRALCEVNNAE 584
+ S E + + +L +Q++ S E + EV E
Sbjct: 2221 E------SEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEE 2274
Query: 585 GSCIEERNVDLKNNSLEIDQTENVKPMLRGR---FQRPKPNLSRAGKKSVLSQGKTESES 641
G EE+ V+ + + + E K ++ + F+ + +S +S LS + E ES
Sbjct: 2275 G---EEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETES-LSDEEEEEES 2330
Query: 642 KNSHSKTSVEKNHVEKDKMNTLDILRMET 670
+ + EK ++K+K L R ++
Sbjct: 2331 CSLEEEVDREKEILKKEKQFKLQEQRRKS 2359
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 75.1 bits (183), Expect = 9e-13
Identities = 316/1746 (18%), Positives = 658/1746 (37%), Gaps = 285/1746 (16%)
Query: 419 ESMSSRISDTERSQKDAQTVEEESLTLSREDAEQVALEVDLNQKKR---RRKKQDGANEL 475
+S S + D E+++ + Q E ESL S +Q E + N + +K+ +E
Sbjct: 1322 KSKLSSLQDLEKTKLEEQVQELESLISS---LQQQLKETEQNYEAEIHCLQKRLQAVSES 1378
Query: 476 GVNNLLENATVQAGPSKGEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGIVGFASTEK 535
V L +V S ++ + G C K+ NIDG + F+
Sbjct: 1379 TVPPSLPVDSVVITESDAQR----------TMYPGSCVKK-------NIDGTIEFSGEFG 1421
Query: 536 VEKRTDPILSLSNQQDA--------TSVATESSESSTSDLPSFEVGIRALCEVNNAEGSC 587
V++ T+ + L Q V+ + + ++L G A C
Sbjct: 1422 VKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVC 1481
Query: 588 IEERN----VDLKNNSLEIDQTENVKPMLRGRFQRPKPNLSRAGKKSVLSQGK------- 636
+E++ + L + + E V + F+ L GK+ +LS
Sbjct: 1482 QQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPES 1541
Query: 637 -----TESESKNSHSKTSVEKNHVEKD-KMNTLDILRMETTERENPEAETVSVLGEKNCL 690
T SE S KT + + + + ++++D R E E ++ +
Sbjct: 1542 KDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEH 1601
Query: 691 QEGSQLKALRPVQVRGRLQKPKPNAGKAAERKEILISQEEIGANVEKNENESCADRDTPQ 750
Q+ ++L LR +R ++++ + + + E + L Q ++++ S +R +
Sbjct: 1602 QQATEL--LRQAHMR-QMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLE 1658
Query: 751 HMEDQSRKDFEEEDVILQPEKNDSFQNVQPDEPKVLNECLSVQENNKANKLNQVP---IL 807
+E + + + +N S Q +E + E + +E K VP +
Sbjct: 1659 ELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILS 1718
Query: 808 RTRFQKPKPNIGRGTGRREISSKEEVLEKILVSGEMAAALRETVR------LDTSPKEMV 861
R+ K N +L+ +L + AA+ ET+ LD S K
Sbjct: 1719 NERYALQKAN-------------NRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQS 1765
Query: 862 PAEINTK-EMQSDLKETGRRAISPREKILDVIDDTIEMETGLKAMGREICLREKTPEVID 920
A + + E ++ +K E+ V D++I +G +I + K
Sbjct: 1766 SASLIWRSEAEASVKSC------VHEEHTRVTDESIPSYSGSDMPRNDINMWSKV----- 1814
Query: 921 ATEEIDKDLEEAGRREISPQKNGPEEVKPLGEVETDLKATGNESSPREKTPEVTDATEEI 980
TEE + + R + + PE + + + + L+A + E E + E
Sbjct: 1815 -TEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLL--EAISETSSQLEHA 1871
Query: 981 DKNLEETGRRKISPRENGPEEVKPVDEMETDLNATGRESSPREKTPEVIDATEEIDLEET 1040
E R ++ E +K +E+ L+ ES RE+ ++L +
Sbjct: 1872 KVTQTELMRESFRQKQEATESLKCQEELRERLH---EESRAREQLA--------VELSKA 1920
Query: 1041 EREVSPQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEVIDAIEEIEIDLEETEREISP 1100
E + +G + K L E + K ++ID +E+ + +E+
Sbjct: 1921 EGVI----DGYADEKTLFERQIQEKT------------DIIDRLEQELLCASNRLQELEA 1964
Query: 1101 QENGLEEVKPLGEMQTDLKATGREISPREKTPEVIDATEEIDKDLEETGRREISPEENGP 1160
++ ++E + L Q + A E P E+ +++ TE++ K+ E + ++
Sbjct: 1965 EQQQIQEERELLSRQKE--AMKAEAGPVEQ--QLLQETEKLMKEKLEVQCQAEKVRDDLQ 2020
Query: 1161 EEVKPVDEMETDLKTTGREGSSREKTREVIDAAE---VIETDLEETEREISPQENGPEEV 1217
++VK + E++ + + + +EK E++D + +E LE+ + + Q E
Sbjct: 2021 KQVKAL-EIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHE 2079
Query: 1218 KPVGKMETDLKEIREEISQREKVLAEFSAIREKEI-DLKETGKRDIPIMEKVSGKMAVVE 1276
+ V + E +++ Q+ KV+ F I E + ++++ +K S + E
Sbjct: 2080 RDVFQQEI------QKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKE 2133
Query: 1277 EMEADLKETGKE----NFRERGSEEICV----TEEKVAELKQTGKTDISPRENELEETST 1328
+++ D++E +E FR R E+ + T +KV + K G + P
Sbjct: 2134 QLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKP---------- 2183
Query: 1329 SRQTDTHLMQSGSNDFSAVPSLDIQNISSEVLSMMHTPVEEKRNSEKEVSSHFSHFKISS 1388
+ + D +I N+ ++ EE N +EV H ++
Sbjct: 2184 --ELSLEVQLQAERDAIDRKEKEITNLEEQLEQFR----EELENKNEEVQQ--LHMQLEI 2235
Query: 1389 QTHESDKTEVQGIQSPDVPEQFSDINLSKSLPQEQKPLEIKPAPFVRSRFKRPKPNLARA 1448
Q ES T +Q ++ + + F D E+ L IK + +
Sbjct: 2236 QKKEST-TRLQELEQEN--KLFKD-------DMEKLGLAIKESDAM-------------- 2271
Query: 1449 ALKRETTESEKYIYEKKSETKKMETIVMQENNEQTDTLPSQHDEASLMISREKDTLGHRN 1508
+T+ + ++ K ++ + + + + + NEQ L Q L I+ + + +N
Sbjct: 2272 -----STQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQ-----LKITTDNKVIEEKN 2321
Query: 1509 EEA----VILPCTQTERNLSPSNSCEPKEESQSAPVQKNDSVVSVGTN---NVNTFQQE- 1560
E + C +++ N E E+ + + ++G N ++ +E
Sbjct: 2322 ELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEA 2381
Query: 1561 --MKESV-IQTARQVRGRLQRPRPNIRKTGQRQIVDKGEAK--GIIKEGRTILPKDETEK 1615
+K + + A ++ Q N T + ++ + K + +E ++ + E+ +
Sbjct: 2382 DSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVE 2441
Query: 1616 KVLTVSNSQIETEIEVPSSAVPEHRMYENQSQVVLVENLHVNKTNETIRHENKPYVPSSA 1675
K+ ++ + + I+ S PE +VVL E+ + N+T Y S
Sbjct: 2442 KIQSIPENSVNVAIDHLSKDKPE-------LEVVLTEDALKSLENQT-------YFKSFE 2487
Query: 1676 QMTRRKFQKAKPNLGRAHSKKEEPVLE-----KVTTDQSKEGKPEDHLLQKGASNTQLLL 1730
+ + + L + S LE K D ++G+ E +LQK N Q ++
Sbjct: 2488 ENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIV 2547
Query: 1731 KEK--AELLTSLEVSA-----------------------------RKDCVGSKESAL--- 1756
+EK A L++ +++ A R+D +GS SAL
Sbjct: 2548 EEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLR 2607
Query: 1757 -AKIDAELEEVGPSRRVGEETVGDNSPSSVVEEQ----YLNKLTSCPQPLNETSYSKIAL 1811
+++++++ E+ S + +E V + + +V+E++ L KL + K +
Sbjct: 2608 ISELESQVVEMHTSLILEKEQV-EIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSP 2666
Query: 1812 DGKTTISSTSEYERNRGERRSHKKFKPNVTRGRGSKRVRGKTSKKEPRASKAMLV---TL 1868
+ +T+E + E + + +K +K + + +LV +
Sbjct: 2667 QDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNM 2726
Query: 1869 RASQEEDDDADDFESDYEEESYHLAPE------EVNKAPVFVPVGLRSPEPVSAQIEETM 1922
+ Q++ D ++ +E+ L E E KA +F P+ ++ + +++Q + T+
Sbjct: 2727 TSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTL 2786
Query: 1923 E----ELEITVNVPDVGCIAVVEHELPNTDVTTEEMKQEENLSVPFEMTTSEHIQDEPGT 1978
+ + V + G ++ E + +VT + E + E+ +E I D
Sbjct: 2787 KISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAE-ILDMESR 2845
Query: 1979 NDGSTEAAITLLTMGDLVLQSEISSEQGDVGVCIIPHVHSKDKSHIPSSLDNVNHKIVHE 2038
+ TE L V + E G + +I + SK+ S IP + H ++
Sbjct: 2846 HISETET----LKREHYVAVQLLKEECGTL-KAVIQCLRSKEGSSIP----ELAHSDAYQ 2896
Query: 2039 CQELSS 2044
+E+ S
Sbjct: 2897 TREICS 2902
Score = 57.4 bits (137), Expect = 2e-07
Identities = 225/1225 (18%), Positives = 463/1225 (37%), Gaps = 198/1225 (16%)
Query: 375 LAEEEKRKQKSVKNHSLKEKKSTKPRKNVKVKKVACEGVNNDPDESMSSRISDTERSQKD 434
LA+ +RK +S K++K + + K A +N D + I+ ++R +
Sbjct: 17 LAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQCNEMYINSSQRVEST 76
Query: 435 A-------QTVEEESLTLSREDAEQVALEVDLNQKKRRRKKQDGA--------------- 472
+T+ +T S E V LE +++ +
Sbjct: 77 VIPESTIMRTLHSGEIT-SHEQGFSVELESEISTTADDCSSEVNGCSFVMRTGKPTNLLR 135
Query: 473 -NELGVNNLLENATVQAGPSKGEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGIVGFA 531
E GV++ Q P+ E +++ + E++E E+M T +G+
Sbjct: 136 EEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEM-RVTYGTEGLQQLQ 194
Query: 532 STEKVEKRTDPILS--LSNQQDATSVATESSESS---TSDLPSFEVGIRALCEVNNAEGS 586
E K+ D I++ +N Q A E+ T ++ + L S
Sbjct: 195 EFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNS 254
Query: 587 CIEERNVDL---KNNSLEIDQTENVKPMLRGRFQRPKPN----LSRAGKKSVLSQGKTES 639
DL K L Q + L +Q+ K + +S +K + + + +
Sbjct: 255 THSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDK 314
Query: 640 ESKNSHSKTSVEKNHVEKDKMNTLDILRMETTERENPEAETVSVLGE--KNCLQEGSQLK 697
+ +NS+ + EK + ++ + +T E ++ +LGE + +Q+ ++K
Sbjct: 315 KVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIK 374
Query: 698 ALRPVQVRGRLQKPKPNAGKAAERKEILISQEEIGANVEKNENESCADRDTPQHMEDQSR 757
++ +++ QK + ++ E K+++ + EE+ ++N +S + D Q ME +++
Sbjct: 375 NMK-LELTNSKQKERQSS---EEIKQLMGTVEELQ---KRNHKDSQFETDIVQRMEQETQ 427
Query: 758 KDFEEEDVILQPEKNDSF--QNVQPDEPKVLNECLSVQENNKANKLNQVPILRTRFQKPK 815
+ E+ L+ E ++ + Q VQ + + ++E ++TR +
Sbjct: 428 RKLEQ----LRAELDEMYGQQIVQMKQELIRQHMAQMEE------------MKTRHK--- 468
Query: 816 PNIGRGTGRREISSKEEVLEKILVSGEMAAALRETVRLDTSPKEMVPAEINTKEMQSDLK 875
GEM ALR + + ++ + E+ L+
Sbjct: 469 -------------------------GEMENALRSYSNITVNEDQIKLMNVAINELNIKLQ 503
Query: 876 ETGRRAISPREKILDVIDDTIEMETGLKAMGREICL-REKTPEVIDATEEIDKDLEEAG- 933
+T + +E++ ++++ ++ L+ + E+ RE+ E + L EA
Sbjct: 504 DTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHK 563
Query: 934 --------RREISPQKNGPEEVKPLGEVETDLKATGNESSPREKTPEVTDATEEIDKNLE 985
+ EI +E++ E E E +EK + E + LE
Sbjct: 564 SLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELE 623
Query: 986 ETGRRKISPRENGPEEVKPVDEMETDLNATGRESSPREKTPEVIDA-----TEEIDLEET 1040
+ + E ++K E+E +N + + + ID +++I+ +
Sbjct: 624 RLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQF 683
Query: 1041 ERE--VSPQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEVIDAIEEIEIDLEETEREI 1098
E++ ++ Q + E+ L +++ L +S T ++ + +EIEI L + E+E
Sbjct: 684 EKDNLITKQNQLILEISKLKDLQQSLV----NSKSEEMTLQINELQKEIEI-LRQEEKEK 738
Query: 1099 SPQENGLEEVKPLGEMQTDLKATGREISPREKTPEVIDATEEIDKDLEET------GRRE 1152
E ++E++ E+ + + +E +EK + ++A I KD ++T
Sbjct: 739 GTLEQEVQELQLKTEL-LEKQMKEKENDLQEKFAQ-LEAENSILKDEKKTLEDMLKIHTP 796
Query: 1153 ISPEEN---------------GPEEVKPVDEMETDLKTTGRE-GSSREKTREVIDAAEV- 1195
+S EE +E++ + E DLK + EK R AE
Sbjct: 797 VSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKN 856
Query: 1196 IETDLEETERE---ISPQENGPEEVKPVGKME--TDLKEIREE----------ISQREKV 1240
E + +E + E + ++ E+ K ++E + LK + EE + + V
Sbjct: 857 FEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSV 916
Query: 1241 LAEFSAIREKEIDLKETGKRD-IPIMEKVSGKMAVVEEMEADLKETGKENFRERGSEEIC 1299
E + +++ E ++D +MEK+ E+ L + ++ ++ G EI
Sbjct: 917 FDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHG--EIS 974
Query: 1300 VTEEKVAELKQTGKTDISPRENELEETSTSRQTDTHLMQSGSNDFSAVPSLDIQNISSEV 1359
E+V LKQ K +S R ELE + + ++Q+ ++V
Sbjct: 975 FLNEEVKSLKQE-KEQVSLRCRELEIIINHNRAE-----------------NVQSCDTQV 1016
Query: 1360 LSMMHTPVE-EKRNSEKEVSSHFSHFKISSQTHESDKTEVQGIQSPDVPEQFSDINLSKS 1418
S++ V R +E VS F S+ DK F ++ + +
Sbjct: 1017 SSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKV------------SFENMTVGEE 1064
Query: 1419 LPQEQKPLEIKPAPFVRSRFKRPKPNLARAALKRETTESEKYIYEKKSETKKMETIVMQE 1478
QEQ L+ P+ S + +P+ E + +K + KSE + + M+
Sbjct: 1065 SKQEQLILDHLPSVTKESSLRATQPS--------ENDKLQKELNVLKSEQNDLR-LQMEA 1115
Query: 1479 NNEQTDTLPSQH-DEASLMISREKD 1502
+ S H D+ + EKD
Sbjct: 1116 QRICLSLVYSTHVDQVREYMENEKD 1140
Score = 52.4 bits (124), Expect = 6e-06
Identities = 119/665 (17%), Positives = 258/665 (38%), Gaps = 103/665 (15%)
Query: 923 EEIDKDLEEAGRREISPQKNGPEEVKPLGEVETDLKATGNESSPREKTPEVTDATEEIDK 982
EE++++LEE G E ++ L E E +K + ++T ++ +
Sbjct: 172 EELNRELEEMR------VTYGTEGLQQLQEFEAAIKQRDGIIT------QLTANLQQARR 219
Query: 983 NLEETGRRKISPRENGPEEVKPVDEMETDLNATGRESSPREKTPEVIDATEEI------- 1035
+ET R + E + + + + T R S+ +++ A ++I
Sbjct: 220 EKDETMREFLELTEQSQK--LQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQL 277
Query: 1036 --------DLEETEREVSPQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEVIDAIEEI 1087
D ++ + + + Q + L+E + EME D K + + + E IEE+
Sbjct: 278 EEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSN---KEEIQEKETIIEEL 334
Query: 1088 EIDLEETEREISPQENGLEEV-KPLGEMQTDLKATGREISPREKTPEVIDATEEIDKDLE 1146
+ E E++ ++ L K LGE+Q + +EI + E+ ++ ++ + E
Sbjct: 335 NTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEI--KNMKLELTNSKQKERQSSE 392
Query: 1147 ETGRREISPEENGPEEVKPVDEMETDLKTTGREGSSREKTREVIDAAEVIETDLEETERE 1206
E + + EE K + ETD+ + + R+ + + E+ + + ++E
Sbjct: 393 EIKQLMGTVEELQKRNHKD-SQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQE 451
Query: 1207 ISPQENGP-EEVKP--VGKMETDLKEIREEISQREKVLAEFSAIREKEIDLKETGKRDIP 1263
+ Q EE+K G+ME L+ +++ AI E I L++T +
Sbjct: 452 LIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQK-- 509
Query: 1264 IMEKVSGKMAVVEEMEADLKETGKENFRERGSEEICVTEEKVAELKQTGKTDISPRENEL 1323
EK+ ++ ++ E + L+ ++ EE+ + E++ +QT I+ +E++L
Sbjct: 510 --EKLKEELGLILEEKCALQRQLEDLV-----EELSFSREQIQRARQT----IAEQESKL 558
Query: 1324 EETSTSRQTDTHLMQSGSNDFSAVPSLDIQNISSEVLSMMHTPVEEKRNSEKEVSSHFSH 1383
E S T ++++ +E++S + E + E EV++
Sbjct: 559 NEAHKSLST-------------------VEDLKAEIVSASESRKELELKHEAEVTN---- 595
Query: 1384 FKISSQTHESDKTEVQGIQSPDVPEQFSDINLSKSLPQEQKPLEIKPAPFVRSRFKRPKP 1443
+KI + E +K V + + + E++ ++K
Sbjct: 596 YKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLK-------------- 641
Query: 1444 NLARAALKRETTESEKYIYEKKSETKKMETIVMQENNEQTDTLPSQHDEASLMISREKDT 1503
E E + +K++ + +Q D L ++ + + EKD
Sbjct: 642 --------------EDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDN 687
Query: 1504 LGHRNEEAVILPCTQTERNLSPSNSCEPKEESQSAPVQKNDSVVSVGTNNVNTFQQEMKE 1563
L + + ++ + S NS + Q +QK ++ T +QE++E
Sbjct: 688 LITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQE 747
Query: 1564 SVIQT 1568
++T
Sbjct: 748 LQLKT 752
Score = 50.1 bits (118), Expect = 3e-05
Identities = 302/1635 (18%), Positives = 640/1635 (39%), Gaps = 270/1635 (16%)
Query: 344 EEKTNGWRIDKAFQEKRPFDFDFFAHLLQKVLAEEEKRKQKSVKNHSLKEKKSTKPRKNV 403
+EKT ++ QEK D L Q++L + ++ + ++E++ R+
Sbjct: 1929 DEKT---LFERQIQEKT----DIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKE 1981
Query: 404 KVKKVACEGVNNDPDESMSSRISDTERSQKDAQTVEEESLTLSREDAEQV-ALEVDLNQK 462
+K A P E + +TE+ K+ V+ ++ + + +QV ALE+D+ ++
Sbjct: 1982 AMKAEA------GPVEQQL--LQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQ 2033
Query: 463 KRR--RKKQDGANELGVNNLLENATVQAGPSKGEKHKNKCQAIRPELKEGECSKEQMLSC 520
R +Q+ EL ++ +N ++ K K ++ QAI E E + ++++
Sbjct: 2034 VSRFIELEQEKNTEL-MDLRQQNQALEKQLEKMRKFLDE-QAIDRE-HERDVFQQEIQKL 2090
Query: 521 TQNIDGIVGFASTEKVEKRTDPILS--LSNQQDATSVATESSESSTSDLPSFEVGIRALC 578
Q + + F + + R L+ L + D S S E D
Sbjct: 2091 EQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRD------------ 2138
Query: 579 EVNNAEGSCIEERNVDLKNNSLEIDQTENVKPMLRGRFQRPKPNLSRAGKKSVLSQGKTE 638
I+ERN +++ + + E + FQ+ + R +V ++ +
Sbjct: 2139 ---------IQERNEEIEKLEFRVRELEQALLVSADTFQKVE---DRKHFGAVEAKPELS 2186
Query: 639 SESKNSHSKTSVEKNHVEKDKMNTLDILRMETTERENPEAETVSVLGEKNCLQEGSQLKA 698
E + + ++++ EK+ N + L E EN E V L + +Q+
Sbjct: 2187 LEVQLQAERDAIDRK--EKEITNLEEQLEQFREELENKNEE-VQQLHMQLEIQKKESTTR 2243
Query: 699 LRPVQVRGRLQKPK-PNAGKAAERKEILISQEE------IGANVEKNENESCADRDTPQH 751
L+ ++ +L K G A + + + +Q++ +++ E E D+ Q
Sbjct: 2244 LQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVE--IDQLNEQV 2301
Query: 752 MEDQSRKDFEEEDVILQPEKNDSFQNVQPDEPKVLN--ECLSVQENNKANKLNQVPILRT 809
+ Q + ++ +++ EKN+ ++++ +++ EC+ + +LN+V
Sbjct: 2302 TKLQQQLKITTDNKVIE-EKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVI---E 2357
Query: 810 RFQKPKPNIGRGTGRREISSKEEVLE-KILVSGEMAAALRETVRLDTSPKEMVPAEINTK 868
+ Q+ NIG+ T S EE K + +A L +++T+ +EM + K
Sbjct: 2358 KLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLK 2417
Query: 869 EMQSDLKETGRRAISPR------EKILDVIDDTIEM-----------------ETGLKAM 905
E + + + S + EKI + ++++ + E LK++
Sbjct: 2418 ETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSL 2477
Query: 906 --------------GREICLREKTPEVIDATEEIDKDLEEAGRREISPQKNGPEEVKPLG 951
G I L + ++ D +L + ++ Q+ G E + L
Sbjct: 2478 ENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQ 2537
Query: 952 EVETDLKATGNESSPREKTPEVT-DATEEIDKNLEETGRRKISPRENGPEEVKPV--DEM 1008
+ +L+ E ++ +A +E K ++ P + + + DE+
Sbjct: 2538 KKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDEL 2597
Query: 1009 ETDLNATGRESSPREKTPEVIDATEEIDLEETEREVSPQENGLEEVKPLGEMETDLKATG 1068
+D++A S E +V++ + LE+ + E++ ++N LE+ K L E++ L+ G
Sbjct: 2598 GSDISALTLRISELES--QVVEMHTSLILEKEQVEIA-EKNVLEKEKKLLELQKLLE--G 2652
Query: 1069 RDSFPRGKTPEVIDAIEEIEIDLEETEREISPQENGLEEVKPLGEMQTDLKATGREISPR 1128
+ R K E + +++E+ TE S +E+G L ++ + AT E++
Sbjct: 2653 NEKKQREK--EKKRSPQDVEVLKTTTELFHSNEESGF--FNELEALRAESVATKAELASY 2708
Query: 1129 EKTPEVIDATEEIDKDLEETGRREISPEENGPEEVKP-VDEMETDLKTTGREGSSREKTR 1187
++ E + + + + ++++S + E K + +E + +T +E
Sbjct: 2709 KEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFE 2768
Query: 1188 EV-IDAAEVIETDLEETEREISPQENGPEEVKPVG-----KMETDLKEIREEISQ----- 1236
+ I ++ I + + T + S + VK G + E +E+ E ISQ
Sbjct: 2769 PLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKI 2828
Query: 1237 ---REKVLAEFSAIREKEIDLKETGKRD----IPIMEKVSGKMAVV-------------E 1276
+E AE + + I ET KR+ + ++++ G + V E
Sbjct: 2829 EKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPE 2888
Query: 1277 EMEADLKETGKENFRERGSE---EICVTEEKVAELKQTGK-------TDISPRE------ 1320
+D +T + + GS+ I +T + ++ G+ TD P++
Sbjct: 2889 LAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLR 2948
Query: 1321 ---NE------LEETSTSRQTDTHLMQSGSNDFSAVPSLDIQNISSEVLSMMHTPVEEKR 1371
NE L E+ S D H +Q S + I ISS L + T ++ +R
Sbjct: 2949 AVHNEGMQVLSLTESPYSDGED-HSIQQVSEPWLEERKAYINTISS--LKDLITKMQLQR 3005
Query: 1372 NSEKEVSSHFSHFKISSQTHE------------------SDKTEVQGIQSPDVPEQFSDI 1413
+E SS SH S E + +TE+ + + D +
Sbjct: 3006 EAEVYDSSQ-SHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDA------V 3058
Query: 1414 NLSKSLPQ--EQKPLEIKPAPFVRSRFKR-----------PKPNLARAALKRETTESEKY 1460
L L Q +++ +E + A + R + N + LKRE ESEK
Sbjct: 3059 GLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQ-ESEKP 3117
Query: 1461 IYEKKSETKKMETIVMQENNEQTDTLPSQHDEASLMISREKDTLGHRNEEAVILPCTQTE 1520
E + + M E + ++ + E +S EK + E QT+
Sbjct: 3118 SQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELA-----QTK 3172
Query: 1521 RNLSPSNSCEPK--EESQSAPVQKNDSVVSVGTNNVNTFQQEMKESVIQTARQVRGRLQR 1578
L + + K +E ++ ++ D V N +T E K+S R+++ L++
Sbjct: 3173 LELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLN-DTLASEQKKS-----RELQWALEK 3226
Query: 1579 PRPNIRKTGQRQIVDKGEAKGIIKEGRT----ILPKDETEKKVLTVSNSQIETEIEVPSS 1634
+ + ++ +R + + K ++ + + E +K++L S +IE++ + +
Sbjct: 3227 EKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDA 3286
Query: 1635 AVPEHRMYENQSQVVLV-ENLHVNKTNETIRHE---------------NKPYVPSSAQMT 1678
+ E + + QV+L E + + + + T+ E ++P +PS +
Sbjct: 3287 QLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLK 3346
Query: 1679 --RRKFQKAKPNLGRAHSKKEEPVLEKVTTDQ-------------------SKEGKPEDH 1717
+++ ++ + ++ E+ L+ + T Q + EG+ + H
Sbjct: 3347 ELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMH 3406
Query: 1718 LLQKGASNTQLLLKEKAELLTSLEVSARKDCVGSKESALAKIDAELEEVGPSRRVGEETV 1777
LQ + Q L+EK + + L++ ++ + K + E EE SRR+ + +
Sbjct: 3407 ELQSKVEDLQRQLEEKRQQVYKLDLEGQR--LQGIMQEFQKQELEREEKRESRRILYQNL 3464
Query: 1778 GDNSPSSVVEEQYLN 1792
+ + S+ ++ N
Sbjct: 3465 NEPTTWSLTSDRTRN 3479
Score = 45.4 bits (106), Expect = 7e-04
Identities = 169/929 (18%), Positives = 355/929 (38%), Gaps = 187/929 (20%)
Query: 1196 IETDLEETEREISPQENGPEEVKPVGKMETDLKEIREEISQREKVLAEFSAIREKEIDLK 1255
+E+++ T + S + NG V GK T+L +REE EF +
Sbjct: 103 LESEISTTADDCSSEVNGCSFVMRTGK-PTNL--LREE---------EFGV----DDSYS 146
Query: 1256 ETGKRDIP----IME-KVSGKMAVVEEMEADLKET----GKENFRERGSEEICVTEEKVA 1306
E G +D P +ME +++GK +EE+ +L+E G E ++ E + +
Sbjct: 147 EQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGI 206
Query: 1307 ELKQTGKTDISPREN--------ELEETSTSRQTDTHLMQSGS---NDFSAVPSLDIQNI 1355
+ T + RE EL E S Q +Q+ N + + D+
Sbjct: 207 ITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQA 266
Query: 1356 SSEVLSMMHTPVEE--------KRNSEKEVSSHFSHFKISSQTHESDKTEVQGIQSPDVP 1407
++L+ E+ K+ + + F KI E DK +V+ ++
Sbjct: 267 KQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDK-KVENSNKEEIQ 325
Query: 1408 EQ---FSDINLSKSLPQEQKPLEIKPAPFVRSRFKRPKPNLARAALKRETTESEKYIYEK 1464
E+ ++N +K + +E+K LE LK + T ++K + E
Sbjct: 326 EKETIIEELN-TKIIEEEKKTLE----------------------LKDKLTTADKLLGEL 362
Query: 1465 KSETKKMETIVMQENNEQTDTLPSQHDEASLMISREKDTLGHRNEEAVILPCTQTERNLS 1524
+ + ++Q+N E ++ + L S++K+ R I T L
Sbjct: 363 QEQ-------IVQKNQE------IKNMKLELTNSKQKE----RQSSEEIKQLMGTVEELQ 405
Query: 1525 PSNSCEPKEESQSAPVQKNDSVVSVGTNNVNTFQQEMKESVIQTARQVRGRLQRPRPNIR 1584
N + + E+ + ++ + + E+ E Q Q++ L R ++
Sbjct: 406 KRNHKDSQFETDIVQRMEQET-----QRKLEQLRAELDEMYGQQIVQMKQELIRQ--HMA 458
Query: 1585 KTGQRQIVDKGEAKGIIKEGRTILPKDETEKKVLTVSNSQIETEIEVPSSAVPEHRMYEN 1644
+ + + KGE + ++ I +E + K++ V+ +++ +++ +S + +
Sbjct: 459 QMEEMKTRHKGEMENALRSYSNITV-NEDQIKLMNVAINELNIKLQDTNS---QKEKLKE 514
Query: 1645 QSQVVLVENLHVNKTNETIRHENKPYVPSSAQMTRRKFQKAKPNLGRAHSKKEEPVLEKV 1704
+ ++L E + + E + E +R + Q+A+ + SK E
Sbjct: 515 ELGLILEEKCALQRQLEDLVEE--------LSFSREQIQRARQTIAEQESKLNEA----- 561
Query: 1705 TTDQSKEGKPEDHLLQKGASNTQLLLKEKAELLTSLEVSARKDCVGSKESALAKIDAELE 1764
K S + L KAE++++ E +RK+ E+ + +LE
Sbjct: 562 ---------------HKSLSTVEDL---KAEIVSASE--SRKELELKHEAEVTNYKIKLE 601
Query: 1765 EVGPSRRVGEETVGDNSPSSVVEEQYLNKLTSCPQPLNETSYSKIALDGKTTISSTSEYE 1824
+ + + + ++ +E L +L + +E SK+ D I E
Sbjct: 602 MLEKEKNAVLDRMAES------QEAELERLRTQLLFSHEEELSKLKED--LEIEHRINIE 653
Query: 1825 RNRGERRSHKKFKPNVTRGRGSKRVRGKTSKKEPRASKAMLVTLRASQEEDDDADDFESD 1884
+ + H K + + + S+++ +K+ +K + L S+ +D S
Sbjct: 654 KLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSK 713
Query: 1885 YEEESYHLAPEEVNKAPVFVPVGLRSPEPVSAQIEETMEELEITVNVPDVGCIAVVEHEL 1944
EE + ++N+ + + LR E +E+ ++EL++
Sbjct: 714 SEEMTL-----QINELQKEIEI-LRQEEKEKGTLEQEVQELQL----------------- 750
Query: 1945 PNTDVTTEEMKQEEN-LSVPFEMTTSEH--IQDEPGTNDGSTEAAITLLTMGDLVLQSEI 2001
T++ ++MK++EN L F +E+ ++DE T + L + + +
Sbjct: 751 -KTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDM------------LKIHTPV 797
Query: 2002 SSEQGDVGVCIIPHVHSKDKSHIPSS----LDNVNHKIVHECQELSSPVITT-SPASFEE 2056
S E+ + + + SK K + L N + +C +L+ + + SF E
Sbjct: 798 SQEER---LIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAE 854
Query: 2057 NKIVLEEQSSREEISLMEKVKENATPTRN 2085
+ Q +EE + + KVK++ ++N
Sbjct: 855 KNFEVNYQELQEEYACLLKVKDDLEDSKN 883
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 75.1 bits (183), Expect = 9e-13
Identities = 297/1514 (19%), Positives = 566/1514 (37%), Gaps = 279/1514 (18%)
Query: 366 FFAHLLQKVLAEEEKR---KQKSVKNHSLKEKKSTKPRKNVKVK-----KVACEGVNNDP 417
F + L+++ EEE+R +Q++ + L E ++ ++ + K E +
Sbjct: 1336 FISETLRRM--EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1393
Query: 418 DESMSSRISDTERSQKDAQ----TVEEESLTLSREDAEQV---ALEVDLNQKKRRRKKQD 470
+ M + E + DAQ +++EE L + ++ A + + ++ R R ++
Sbjct: 1394 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE- 1452
Query: 471 GANELGVNNL-LENATVQAGPSKGEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGIVG 529
E+ V L LE Q G ++GE QA+R +E E K Q + + V
Sbjct: 1453 ---EIRVVRLQLEATERQRGGAEGE-----LQALRARAEEAEAQKRQAQEEAERLRRQVQ 1504
Query: 530 FASTEKVEKRTDPILSLSNQQDATSVATESSESSTSDLPSFEVGIRALCEVNNAEGSCIE 589
S K + + L+++ A + A + + ++AL E+ ++
Sbjct: 1505 DESQRKRQAEVE----LASRVKAEAEAAREKQRA----------LQALEELR------LQ 1544
Query: 590 ERNVDLKNNSLEIDQTENVKPMLRGRFQRPKPNLSRAGKKSVLSQGKTESESKNSHSKTS 649
+ + E+++ V+ L ++ ++ L + K + + S
Sbjct: 1545 AEEAERRLRQAEVERARQVQVALE---------TAQRSAEAELQSKRASFAEKTAQLERS 1595
Query: 650 VEKNHVEKDKMNTLDILRMETTERENPEAETVSVLGEKNCLQEGSQLKALRPVQVR---- 705
+++ HV + LR E R +AE E E QLKA +++R
Sbjct: 1596 LQEEHVAVAQ------LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1649
Query: 706 ----------GRLQKPKPNAGKAAERK----EILISQEEIGANVEKNENESCADRDTPQH 751
+K K A + A R+ E + Q E+ A E + A+ Q
Sbjct: 1650 EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL-AEQELEKQRQLAEGTAQQR 1708
Query: 752 ME---------------DQSRKDFEEEDVILQPEKNDSFQNVQPDEPKVLNECLSVQENN 796
+ +Q R+ EEE LQ E + Q Q E + L + + E
Sbjct: 1709 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE-LAKVRAEMEVL 1767
Query: 797 KANKLNQVPILRTRFQKPKPNIGRGTGR-REISSKEEVLEKIL----------------- 838
A+K R+ +K K + GR RE++ + L +
Sbjct: 1768 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ 1827
Query: 839 ------VSGEMAAALRETVRLDTSPKEMVPAEINTKEMQSDLKETGR----RAISPREKI 888
V E AA+ E RL T AEI KE +++ + R A R
Sbjct: 1828 RAEAERVLAEKLAAIGEATRLKTE------AEIALKEKEAENERLRRLAEDEAFQRRRLE 1881
Query: 889 LDVIDDTIEMETGL----KAMGREICLREKTPEVIDATEEIDKDLEE------------- 931
++E L KA E+ E+ +++ T + +EE
Sbjct: 1882 EQAAQHKADIEERLAQLRKASDSEL---ERQKGLVEDTLRQRRQVEEEILALKASFEKAA 1938
Query: 932 AGRREISPQ-----KNGPEEVKPLGEVETDLKATGNESSPREKTPEVTDATEEIDKNL-- 984
AG+ E+ + N + ++ + + +L+A E+ +A E + K+L
Sbjct: 1939 AGKAELELELGRIRSNAEDTLR--SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 1996
Query: 985 -EETGRRKISPRENGPEEVKPVDEMETDLNATGRESSPREKTPEVIDATEEIDLEETERE 1043
EE R++ + E E +K E L + S R+ A + + EE
Sbjct: 1997 EEEAARQRKAALEE-VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA 2055
Query: 1044 VSPQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEVIDAIEEIEIDLEETEREISPQEN 1103
+ Q+ E + L + ++ L RG+ A EE E + ERE +
Sbjct: 2056 FAVQQKEQELQQTLQQEQSVLDQL------RGEAEAARRAAEEAEEARVQAEREAAQSRR 2109
Query: 1104 GLEEVKPL---GEMQTDLKATGREISPREKTPEVIDATEEIDKDLEETGRREISPEENGP 1160
+EE + L E Q +A + A E++ K+ E+ R E+
Sbjct: 2110 QVEEAERLKQSAEEQAQARAQAQA------------AAEKLRKEAEQEAARRAQAEQAAL 2157
Query: 1161 EEVKPVD-EMETDLKTTGREGSSREKTREVIDAAEVIETDLEETEREISPQENGPEEVKP 1219
+ + D EME K E + R+K +V + LEET+ + + + + +K
Sbjct: 2158 RQKQAADAEMEKHKKFA--EQTLRQKA-QVEQELTTLRLQLEETDHQKNLLDEELQRLKA 2214
Query: 1220 VGKMETDLKEIREEISQREKVLAEFSAIREKEIDLK------ETGKRDIPIMEKVSGKMA 1273
E E QR +V E ++R + +L E R + + +K + +
Sbjct: 2215 ---------EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF 2265
Query: 1274 VVEEMEADLKETGKENFRERGSEEICVTEEKVAELKQTGKTDISPR----ENELEETSTS 1329
+ EE E +K+ +E R + V ++ A L+Q + D++ + E L+E +
Sbjct: 2266 LQEEAEK-MKQVAEEAAR------LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA 2318
Query: 1330 RQTDTHLMQSGSNDFSAVPSLDIQNISSEVLSMMHTPVEEKRNSEKEVSSHFSHFKISSQ 1389
Q T L +E+L +E+ +E +++ Q
Sbjct: 2319 VQEATRL-----------------KAEAELLQQQKELAQEQARRLQEDKE-----QMAQQ 2356
Query: 1390 THESDKTEVQGIQSPDVPEQFSDINLSKSLPQEQKPLEIKPAPFVRSRFKRPKPNLARAA 1449
E E QG Q E+ + +S E + L+++ A R++ R + + R
Sbjct: 2357 LAE----ETQGFQRTLEAERQRQLEMSA----EAERLKLRVAEMSRAQ-ARAEEDAQR-- 2405
Query: 1450 LKRETTESEKYIYEKKSETKKMETIV--MQENNEQTDTLPSQHDEASLMISREKDTLGHR 1507
+++ E + ++ + T++ T+V ++ +Q+D + EA + REK+ L
Sbjct: 2406 FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL--- 2462
Query: 1508 NEEAVILPCTQTE-RNLSPSNSCEPKEESQSAPVQKNDSVVSVGT--NNVNTFQQEMKES 1564
+EA +L E + + + + Q + + + DS++ +++ +
Sbjct: 2463 QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2522
Query: 1565 VIQTARQVRGRLQRPRPNIRKTGQRQIVDKGEAK--------GIIKEGRTILPKDE---T 1613
+ A+Q+R QR + + + QR + EA+ G+ ++ + ++
Sbjct: 2523 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2582
Query: 1614 EKKVLTVSNSQIETEIEVPSSAVPEHRMYENQSQVVLVENLHVNKTNETIRH-------E 1666
++++L N ++ ++++ +HR S+ V + KT R E
Sbjct: 2583 QEELLAEENQRLREQLQLLEE---QHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAE 2639
Query: 1667 NKPYVPSSAQMTRRKFQKAKPNLGRAHSKKEEPVLEKVTTDQSKEGKPED--HLLQKGAS 1724
+P S RRK + S +E L + T + + ED H LQ +S
Sbjct: 2640 AEP--EHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSS 2697
Query: 1725 NTQLLLKEKAELLT 1738
LLLK E L+
Sbjct: 2698 IAGLLLKATNEKLS 2711
Score = 68.9 bits (167), Expect = 6e-11
Identities = 233/1260 (18%), Positives = 491/1260 (38%), Gaps = 203/1260 (16%)
Query: 326 GQLFPHRARIEIKNKFKREEKTNGWRIDKAFQEKRPFDFDFFAHLLQKVLAEEEKRKQKS 385
G+L RAR E KR+ + R+ + Q++ L +V AE E ++K
Sbjct: 1473 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1532
Query: 386 VKNHSLKE-----KKSTKPRKNVKVKK-----VACEGVNNDPD-ESMSSRISDTERSQKD 434
+L+E +++ + + +V++ VA E + E S R S E++ +
Sbjct: 1533 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1592
Query: 435 AQTVEEESLTLS--REDAEQVALEVDLNQKKRRRKKQDGANELGVNNLLENATVQAGPSK 492
++++EE + ++ RE+AE+ A + Q + R +++ EL L N
Sbjct: 1593 ERSLQEEHVAVAQLREEAERRAQQ----QAEAERAREEAERELERWQLKAN--------- 1639
Query: 493 GEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGIVGFASTEKVEKRTDPILSLSNQQDA 552
+A+R L+ E ++++ L A E +++ + + A
Sbjct: 1640 --------EALRLRLQAEEVAQQKSL------------AQAEAEKQKEEAEREARRRGKA 1679
Query: 553 TSVATESSESSTSDLPSFEVGIRALCEVNNAEGSCIEERNVDLKNNSLEIDQTENVKPML 612
A E + +L R L E + E+ + L+ E +Q E + +L
Sbjct: 1680 EEQAVRQRELAEQELEK----QRQLAEGTAQQRLAAEQELIRLR---AETEQGEQQRQLL 1732
Query: 613 RGRFQRPKPNLSRAGKKSVLSQGKTESESKNSHSKTSV---EKNHVEKDKMNTLDILRME 669
R L R + + + E+E ++ V K E++ +T + +
Sbjct: 1733 EEELAR----LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE----K 1784
Query: 670 TTERENPEAETVSVLGEKNCLQEGSQLKALRPVQVRGRLQKPKPNAGKAAERKEILI--- 726
+ +R EA L E E ++L+AL R R + A + AE + +L
Sbjct: 1785 SKQRLEAEAGRFRELAE-----EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1839
Query: 727 ----------SQEEIGANVEKNENE--------SCADRDTPQHMEDQSRKDFEEEDVILQ 768
++ EI ++ ENE R + Q + D EE L+
Sbjct: 1840 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1899
Query: 769 PEKNDSFQNVQPDEPKVLNECLSVQENNKANKLNQVPILRTRFQKPKPNIGRGTGRREIS 828
+ + + L + V+E ++ L+ F+K G+ E+
Sbjct: 1900 KASDSELERQKGLVEDTLRQRRQVEE--------EILALKASFEK------AAAGKAEL- 1944
Query: 829 SKEEVLEKILVSGEMAAALRETVRLDTSPKEMVPAEINTKEMQSDLKETGRRAISPREKI 888
E L +I + E +E L+ + + + AE + +++ E +++++ E+
Sbjct: 1945 --ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE--ERVQKSLAAEEEA 2000
Query: 889 LDVIDDTIEMETGLKAMG------REICLREKTPEVIDATEEIDKDLEEAGRREISPQKN 942
+E LKA RE +E ++ A E K L+ + +
Sbjct: 2001 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2060
Query: 943 GPEEVKPLGEVETDL--KATGNESSPREKTPEVTDATEEID-------KNLEETGRRKIS 993
+E++ + E + + G + R E +A + + + +EE R K S
Sbjct: 2061 KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQS 2120
Query: 994 PREN---------GPEEVKPVDEMETDLNATGRESSPREKTPEVIDATEEID---LEETE 1041
E E+++ E E A +++ R+K + DA E E+T
Sbjct: 2121 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK--QAADAEMEKHKKFAEQTL 2178
Query: 1042 REVSPQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEVIDAIEEIEIDLEETEREISPQ 1101
R+ + E L ++ L ETD + D + ++ ++ + E R+ S
Sbjct: 2179 RQKAQVEQELTTLR-LQLEETDHQKNLLD-----------EELQRLKAEATEAARQRSQV 2226
Query: 1102 ENGLEEVK----PLGEMQTDLKATGREISPREKTPE---VIDATEEIDKDLEETGRREIS 1154
E L V+ L +++ ++A R + R+K + + E++ + EE R ++
Sbjct: 2227 EEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2286
Query: 1155 PEENGPEEVKPVDEMETDLKTTGREGSSREKTREVIDAAEV-IETDLEETEREISPQENG 1213
+E ++ + E + + E +EK + V +A + E +L + ++E++ ++
Sbjct: 2287 AQE--AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ-- 2342
Query: 1214 PEEVKPVGKMETDLKEIREEISQREKVLAE-FSAIREKEIDLKETGKRDIPIMEKVSGKM 1272
+++ D +++ +++++ + A R++++++ +R + ++S
Sbjct: 2343 ------ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2396
Query: 1273 AVVEE----MEADLKETGKENFRERGSEEICVTEEKVAELKQTGKTDISPREN----ELE 1324
A EE +E G++ R + + VT + E+++ + R ELE
Sbjct: 2397 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2456
Query: 1325 ETSTSRQTDTHLMQSGSNDFSAVPSLDIQNISSEVLSMMHTPVEEKRNSEKEVSSHFSHF 1384
Q + L+Q + S ++Q + E L +++ SEK+ F
Sbjct: 2457 REKEKLQQEAKLLQ--------LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2508
Query: 1385 KISSQTHESDKTEVQGIQSPDVPEQFSDINLSKSLPQEQKPLEIKPAPFVRSRFK-RPKP 1443
E +K +++ + +V + L + ++Q+ +E + V S + R +
Sbjct: 2509 ------IEQEKAKLEQLFQDEVAKA---QQLREEQQRQQQQMEQERQRLVASMEEARRRQ 2559
Query: 1444 NLARAALKRETTESEKYIYEKKSETKKMETIVMQEN---NEQTDTLPSQHDEASLMISRE 1500
+ A ++R+ E + + + + ++ E ++ +EN EQ L QH A+L S E
Sbjct: 2560 HEAEEGVRRKQEE----LQQLEQQRRQQEELLAEENQRLREQLQLLEEQH-RAALAHSEE 2614
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 75.1 bits (183), Expect = 9e-13
Identities = 297/1514 (19%), Positives = 566/1514 (37%), Gaps = 279/1514 (18%)
Query: 366 FFAHLLQKVLAEEEKR---KQKSVKNHSLKEKKSTKPRKNVKVK-----KVACEGVNNDP 417
F + L+++ EEE+R +Q++ + L E ++ ++ + K E +
Sbjct: 1340 FISETLRRM--EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1397
Query: 418 DESMSSRISDTERSQKDAQ----TVEEESLTLSREDAEQV---ALEVDLNQKKRRRKKQD 470
+ M + E + DAQ +++EE L + ++ A + + ++ R R ++
Sbjct: 1398 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE- 1456
Query: 471 GANELGVNNL-LENATVQAGPSKGEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGIVG 529
E+ V L LE Q G ++GE QA+R +E E K Q + + V
Sbjct: 1457 ---EIRVVRLQLEATERQRGGAEGE-----LQALRARAEEAEAQKRQAQEEAERLRRQVQ 1508
Query: 530 FASTEKVEKRTDPILSLSNQQDATSVATESSESSTSDLPSFEVGIRALCEVNNAEGSCIE 589
S K + + L+++ A + A + + ++AL E+ ++
Sbjct: 1509 DESQRKRQAEVE----LASRVKAEAEAAREKQRA----------LQALEELR------LQ 1548
Query: 590 ERNVDLKNNSLEIDQTENVKPMLRGRFQRPKPNLSRAGKKSVLSQGKTESESKNSHSKTS 649
+ + E+++ V+ L ++ ++ L + K + + S
Sbjct: 1549 AEEAERRLRQAEVERARQVQVALE---------TAQRSAEAELQSKRASFAEKTAQLERS 1599
Query: 650 VEKNHVEKDKMNTLDILRMETTERENPEAETVSVLGEKNCLQEGSQLKALRPVQVR---- 705
+++ HV + LR E R +AE E E QLKA +++R
Sbjct: 1600 LQEEHVAVAQ------LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1653
Query: 706 ----------GRLQKPKPNAGKAAERK----EILISQEEIGANVEKNENESCADRDTPQH 751
+K K A + A R+ E + Q E+ A E + A+ Q
Sbjct: 1654 EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL-AEQELEKQRQLAEGTAQQR 1712
Query: 752 ME---------------DQSRKDFEEEDVILQPEKNDSFQNVQPDEPKVLNECLSVQENN 796
+ +Q R+ EEE LQ E + Q Q E + L + + E
Sbjct: 1713 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE-LAKVRAEMEVL 1771
Query: 797 KANKLNQVPILRTRFQKPKPNIGRGTGR-REISSKEEVLEKIL----------------- 838
A+K R+ +K K + GR RE++ + L +
Sbjct: 1772 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ 1831
Query: 839 ------VSGEMAAALRETVRLDTSPKEMVPAEINTKEMQSDLKETGR----RAISPREKI 888
V E AA+ E RL T AEI KE +++ + R A R
Sbjct: 1832 RAEAERVLAEKLAAIGEATRLKTE------AEIALKEKEAENERLRRLAEDEAFQRRRLE 1885
Query: 889 LDVIDDTIEMETGL----KAMGREICLREKTPEVIDATEEIDKDLEE------------- 931
++E L KA E+ E+ +++ T + +EE
Sbjct: 1886 EQAAQHKADIEERLAQLRKASDSEL---ERQKGLVEDTLRQRRQVEEEILALKASFEKAA 1942
Query: 932 AGRREISPQ-----KNGPEEVKPLGEVETDLKATGNESSPREKTPEVTDATEEIDKNL-- 984
AG+ E+ + N + ++ + + +L+A E+ +A E + K+L
Sbjct: 1943 AGKAELELELGRIRSNAEDTLR--SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 2000
Query: 985 -EETGRRKISPRENGPEEVKPVDEMETDLNATGRESSPREKTPEVIDATEEIDLEETERE 1043
EE R++ + E E +K E L + S R+ A + + EE
Sbjct: 2001 EEEAARQRKAALEE-VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA 2059
Query: 1044 VSPQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEVIDAIEEIEIDLEETEREISPQEN 1103
+ Q+ E + L + ++ L RG+ A EE E + ERE +
Sbjct: 2060 FAVQQKEQELQQTLQQEQSVLDQL------RGEAEAARRAAEEAEEARVQAEREAAQSRR 2113
Query: 1104 GLEEVKPL---GEMQTDLKATGREISPREKTPEVIDATEEIDKDLEETGRREISPEENGP 1160
+EE + L E Q +A + A E++ K+ E+ R E+
Sbjct: 2114 QVEEAERLKQSAEEQAQARAQAQA------------AAEKLRKEAEQEAARRAQAEQAAL 2161
Query: 1161 EEVKPVD-EMETDLKTTGREGSSREKTREVIDAAEVIETDLEETEREISPQENGPEEVKP 1219
+ + D EME K E + R+K +V + LEET+ + + + + +K
Sbjct: 2162 RQKQAADAEMEKHKKFA--EQTLRQKA-QVEQELTTLRLQLEETDHQKNLLDEELQRLKA 2218
Query: 1220 VGKMETDLKEIREEISQREKVLAEFSAIREKEIDLK------ETGKRDIPIMEKVSGKMA 1273
E E QR +V E ++R + +L E R + + +K + +
Sbjct: 2219 ---------EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF 2269
Query: 1274 VVEEMEADLKETGKENFRERGSEEICVTEEKVAELKQTGKTDISPR----ENELEETSTS 1329
+ EE E +K+ +E R + V ++ A L+Q + D++ + E L+E +
Sbjct: 2270 LQEEAEK-MKQVAEEAAR------LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA 2322
Query: 1330 RQTDTHLMQSGSNDFSAVPSLDIQNISSEVLSMMHTPVEEKRNSEKEVSSHFSHFKISSQ 1389
Q T L +E+L +E+ +E +++ Q
Sbjct: 2323 VQEATRL-----------------KAEAELLQQQKELAQEQARRLQEDKE-----QMAQQ 2360
Query: 1390 THESDKTEVQGIQSPDVPEQFSDINLSKSLPQEQKPLEIKPAPFVRSRFKRPKPNLARAA 1449
E E QG Q E+ + +S E + L+++ A R++ R + + R
Sbjct: 2361 LAE----ETQGFQRTLEAERQRQLEMSA----EAERLKLRVAEMSRAQ-ARAEEDAQR-- 2409
Query: 1450 LKRETTESEKYIYEKKSETKKMETIV--MQENNEQTDTLPSQHDEASLMISREKDTLGHR 1507
+++ E + ++ + T++ T+V ++ +Q+D + EA + REK+ L
Sbjct: 2410 FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL--- 2466
Query: 1508 NEEAVILPCTQTE-RNLSPSNSCEPKEESQSAPVQKNDSVVSVGT--NNVNTFQQEMKES 1564
+EA +L E + + + + Q + + + DS++ +++ +
Sbjct: 2467 QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2526
Query: 1565 VIQTARQVRGRLQRPRPNIRKTGQRQIVDKGEAK--------GIIKEGRTILPKDE---T 1613
+ A+Q+R QR + + + QR + EA+ G+ ++ + ++
Sbjct: 2527 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2586
Query: 1614 EKKVLTVSNSQIETEIEVPSSAVPEHRMYENQSQVVLVENLHVNKTNETIRH-------E 1666
++++L N ++ ++++ +HR S+ V + KT R E
Sbjct: 2587 QEELLAEENQRLREQLQLLEE---QHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAE 2643
Query: 1667 NKPYVPSSAQMTRRKFQKAKPNLGRAHSKKEEPVLEKVTTDQSKEGKPED--HLLQKGAS 1724
+P S RRK + S +E L + T + + ED H LQ +S
Sbjct: 2644 AEP--EHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSS 2701
Query: 1725 NTQLLLKEKAELLT 1738
LLLK E L+
Sbjct: 2702 IAGLLLKATNEKLS 2715
Score = 68.9 bits (167), Expect = 6e-11
Identities = 233/1260 (18%), Positives = 491/1260 (38%), Gaps = 203/1260 (16%)
Query: 326 GQLFPHRARIEIKNKFKREEKTNGWRIDKAFQEKRPFDFDFFAHLLQKVLAEEEKRKQKS 385
G+L RAR E KR+ + R+ + Q++ L +V AE E ++K
Sbjct: 1477 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1536
Query: 386 VKNHSLKE-----KKSTKPRKNVKVKK-----VACEGVNNDPD-ESMSSRISDTERSQKD 434
+L+E +++ + + +V++ VA E + E S R S E++ +
Sbjct: 1537 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1596
Query: 435 AQTVEEESLTLS--REDAEQVALEVDLNQKKRRRKKQDGANELGVNNLLENATVQAGPSK 492
++++EE + ++ RE+AE+ A + Q + R +++ EL L N
Sbjct: 1597 ERSLQEEHVAVAQLREEAERRAQQ----QAEAERAREEAERELERWQLKAN--------- 1643
Query: 493 GEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGIVGFASTEKVEKRTDPILSLSNQQDA 552
+A+R L+ E ++++ L A E +++ + + A
Sbjct: 1644 --------EALRLRLQAEEVAQQKSL------------AQAEAEKQKEEAEREARRRGKA 1683
Query: 553 TSVATESSESSTSDLPSFEVGIRALCEVNNAEGSCIEERNVDLKNNSLEIDQTENVKPML 612
A E + +L R L E + E+ + L+ E +Q E + +L
Sbjct: 1684 EEQAVRQRELAEQELEK----QRQLAEGTAQQRLAAEQELIRLR---AETEQGEQQRQLL 1736
Query: 613 RGRFQRPKPNLSRAGKKSVLSQGKTESESKNSHSKTSV---EKNHVEKDKMNTLDILRME 669
R L R + + + E+E ++ V K E++ +T + +
Sbjct: 1737 EEELAR----LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE----K 1788
Query: 670 TTERENPEAETVSVLGEKNCLQEGSQLKALRPVQVRGRLQKPKPNAGKAAERKEILI--- 726
+ +R EA L E E ++L+AL R R + A + AE + +L
Sbjct: 1789 SKQRLEAEAGRFRELAE-----EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1843
Query: 727 ----------SQEEIGANVEKNENE--------SCADRDTPQHMEDQSRKDFEEEDVILQ 768
++ EI ++ ENE R + Q + D EE L+
Sbjct: 1844 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1903
Query: 769 PEKNDSFQNVQPDEPKVLNECLSVQENNKANKLNQVPILRTRFQKPKPNIGRGTGRREIS 828
+ + + L + V+E ++ L+ F+K G+ E+
Sbjct: 1904 KASDSELERQKGLVEDTLRQRRQVEE--------EILALKASFEK------AAAGKAEL- 1948
Query: 829 SKEEVLEKILVSGEMAAALRETVRLDTSPKEMVPAEINTKEMQSDLKETGRRAISPREKI 888
E L +I + E +E L+ + + + AE + +++ E +++++ E+
Sbjct: 1949 --ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE--ERVQKSLAAEEEA 2004
Query: 889 LDVIDDTIEMETGLKAMG------REICLREKTPEVIDATEEIDKDLEEAGRREISPQKN 942
+E LKA RE +E ++ A E K L+ + +
Sbjct: 2005 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2064
Query: 943 GPEEVKPLGEVETDL--KATGNESSPREKTPEVTDATEEID-------KNLEETGRRKIS 993
+E++ + E + + G + R E +A + + + +EE R K S
Sbjct: 2065 KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQS 2124
Query: 994 PREN---------GPEEVKPVDEMETDLNATGRESSPREKTPEVIDATEEID---LEETE 1041
E E+++ E E A +++ R+K + DA E E+T
Sbjct: 2125 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK--QAADAEMEKHKKFAEQTL 2182
Query: 1042 REVSPQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEVIDAIEEIEIDLEETEREISPQ 1101
R+ + E L ++ L ETD + D + ++ ++ + E R+ S
Sbjct: 2183 RQKAQVEQELTTLR-LQLEETDHQKNLLD-----------EELQRLKAEATEAARQRSQV 2230
Query: 1102 ENGLEEVK----PLGEMQTDLKATGREISPREKTPE---VIDATEEIDKDLEETGRREIS 1154
E L V+ L +++ ++A R + R+K + + E++ + EE R ++
Sbjct: 2231 EEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2290
Query: 1155 PEENGPEEVKPVDEMETDLKTTGREGSSREKTREVIDAAEV-IETDLEETEREISPQENG 1213
+E ++ + E + + E +EK + V +A + E +L + ++E++ ++
Sbjct: 2291 AQE--AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ-- 2346
Query: 1214 PEEVKPVGKMETDLKEIREEISQREKVLAE-FSAIREKEIDLKETGKRDIPIMEKVSGKM 1272
+++ D +++ +++++ + A R++++++ +R + ++S
Sbjct: 2347 ------ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2400
Query: 1273 AVVEE----MEADLKETGKENFRERGSEEICVTEEKVAELKQTGKTDISPREN----ELE 1324
A EE +E G++ R + + VT + E+++ + R ELE
Sbjct: 2401 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2460
Query: 1325 ETSTSRQTDTHLMQSGSNDFSAVPSLDIQNISSEVLSMMHTPVEEKRNSEKEVSSHFSHF 1384
Q + L+Q + S ++Q + E L +++ SEK+ F
Sbjct: 2461 REKEKLQQEAKLLQ--------LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2512
Query: 1385 KISSQTHESDKTEVQGIQSPDVPEQFSDINLSKSLPQEQKPLEIKPAPFVRSRFK-RPKP 1443
E +K +++ + +V + L + ++Q+ +E + V S + R +
Sbjct: 2513 ------IEQEKAKLEQLFQDEVAKA---QQLREEQQRQQQQMEQERQRLVASMEEARRRQ 2563
Query: 1444 NLARAALKRETTESEKYIYEKKSETKKMETIVMQEN---NEQTDTLPSQHDEASLMISRE 1500
+ A ++R+ E + + + + ++ E ++ +EN EQ L QH A+L S E
Sbjct: 2564 HEAEEGVRRKQEE----LQQLEQQRRQQEELLAEENQRLREQLQLLEEQH-RAALAHSEE 2618
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 75.1 bits (183), Expect = 9e-13
Identities = 297/1514 (19%), Positives = 566/1514 (37%), Gaps = 279/1514 (18%)
Query: 366 FFAHLLQKVLAEEEKR---KQKSVKNHSLKEKKSTKPRKNVKVK-----KVACEGVNNDP 417
F + L+++ EEE+R +Q++ + L E ++ ++ + K E +
Sbjct: 1336 FISETLRRM--EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1393
Query: 418 DESMSSRISDTERSQKDAQ----TVEEESLTLSREDAEQV---ALEVDLNQKKRRRKKQD 470
+ M + E + DAQ +++EE L + ++ A + + ++ R R ++
Sbjct: 1394 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE- 1452
Query: 471 GANELGVNNL-LENATVQAGPSKGEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGIVG 529
E+ V L LE Q G ++GE QA+R +E E K Q + + V
Sbjct: 1453 ---EIRVVRLQLEATERQRGGAEGE-----LQALRARAEEAEAQKRQAQEEAERLRRQVQ 1504
Query: 530 FASTEKVEKRTDPILSLSNQQDATSVATESSESSTSDLPSFEVGIRALCEVNNAEGSCIE 589
S K + + L+++ A + A + + ++AL E+ ++
Sbjct: 1505 DESQRKRQAEVE----LASRVKAEAEAAREKQRA----------LQALEELR------LQ 1544
Query: 590 ERNVDLKNNSLEIDQTENVKPMLRGRFQRPKPNLSRAGKKSVLSQGKTESESKNSHSKTS 649
+ + E+++ V+ L ++ ++ L + K + + S
Sbjct: 1545 AEEAERRLRQAEVERARQVQVALE---------TAQRSAEAELQSKRASFAEKTAQLERS 1595
Query: 650 VEKNHVEKDKMNTLDILRMETTERENPEAETVSVLGEKNCLQEGSQLKALRPVQVR---- 705
+++ HV + LR E R +AE E E QLKA +++R
Sbjct: 1596 LQEEHVAVAQ------LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1649
Query: 706 ----------GRLQKPKPNAGKAAERK----EILISQEEIGANVEKNENESCADRDTPQH 751
+K K A + A R+ E + Q E+ A E + A+ Q
Sbjct: 1650 EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL-AEQELEKQRQLAEGTAQQR 1708
Query: 752 ME---------------DQSRKDFEEEDVILQPEKNDSFQNVQPDEPKVLNECLSVQENN 796
+ +Q R+ EEE LQ E + Q Q E + L + + E
Sbjct: 1709 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE-LAKVRAEMEVL 1767
Query: 797 KANKLNQVPILRTRFQKPKPNIGRGTGR-REISSKEEVLEKIL----------------- 838
A+K R+ +K K + GR RE++ + L +
Sbjct: 1768 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ 1827
Query: 839 ------VSGEMAAALRETVRLDTSPKEMVPAEINTKEMQSDLKETGR----RAISPREKI 888
V E AA+ E RL T AEI KE +++ + R A R
Sbjct: 1828 RAEAERVLAEKLAAIGEATRLKTE------AEIALKEKEAENERLRRLAEDEAFQRRRLE 1881
Query: 889 LDVIDDTIEMETGL----KAMGREICLREKTPEVIDATEEIDKDLEE------------- 931
++E L KA E+ E+ +++ T + +EE
Sbjct: 1882 EQAAQHKADIEERLAQLRKASDSEL---ERQKGLVEDTLRQRRQVEEEILALKASFEKAA 1938
Query: 932 AGRREISPQ-----KNGPEEVKPLGEVETDLKATGNESSPREKTPEVTDATEEIDKNL-- 984
AG+ E+ + N + ++ + + +L+A E+ +A E + K+L
Sbjct: 1939 AGKAELELELGRIRSNAEDTLR--SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 1996
Query: 985 -EETGRRKISPRENGPEEVKPVDEMETDLNATGRESSPREKTPEVIDATEEIDLEETERE 1043
EE R++ + E E +K E L + S R+ A + + EE
Sbjct: 1997 EEEAARQRKAALEE-VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA 2055
Query: 1044 VSPQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEVIDAIEEIEIDLEETEREISPQEN 1103
+ Q+ E + L + ++ L RG+ A EE E + ERE +
Sbjct: 2056 FAVQQKEQELQQTLQQEQSVLDQL------RGEAEAARRAAEEAEEARVQAEREAAQSRR 2109
Query: 1104 GLEEVKPL---GEMQTDLKATGREISPREKTPEVIDATEEIDKDLEETGRREISPEENGP 1160
+EE + L E Q +A + A E++ K+ E+ R E+
Sbjct: 2110 QVEEAERLKQSAEEQAQARAQAQA------------AAEKLRKEAEQEAARRAQAEQAAL 2157
Query: 1161 EEVKPVD-EMETDLKTTGREGSSREKTREVIDAAEVIETDLEETEREISPQENGPEEVKP 1219
+ + D EME K E + R+K +V + LEET+ + + + + +K
Sbjct: 2158 RQKQAADAEMEKHKKFA--EQTLRQKA-QVEQELTTLRLQLEETDHQKNLLDEELQRLKA 2214
Query: 1220 VGKMETDLKEIREEISQREKVLAEFSAIREKEIDLK------ETGKRDIPIMEKVSGKMA 1273
E E QR +V E ++R + +L E R + + +K + +
Sbjct: 2215 ---------EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF 2265
Query: 1274 VVEEMEADLKETGKENFRERGSEEICVTEEKVAELKQTGKTDISPR----ENELEETSTS 1329
+ EE E +K+ +E R + V ++ A L+Q + D++ + E L+E +
Sbjct: 2266 LQEEAEK-MKQVAEEAAR------LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA 2318
Query: 1330 RQTDTHLMQSGSNDFSAVPSLDIQNISSEVLSMMHTPVEEKRNSEKEVSSHFSHFKISSQ 1389
Q T L +E+L +E+ +E +++ Q
Sbjct: 2319 VQEATRL-----------------KAEAELLQQQKELAQEQARRLQEDKE-----QMAQQ 2356
Query: 1390 THESDKTEVQGIQSPDVPEQFSDINLSKSLPQEQKPLEIKPAPFVRSRFKRPKPNLARAA 1449
E E QG Q E+ + +S E + L+++ A R++ R + + R
Sbjct: 2357 LAE----ETQGFQRTLEAERQRQLEMSA----EAERLKLRVAEMSRAQ-ARAEEDAQR-- 2405
Query: 1450 LKRETTESEKYIYEKKSETKKMETIV--MQENNEQTDTLPSQHDEASLMISREKDTLGHR 1507
+++ E + ++ + T++ T+V ++ +Q+D + EA + REK+ L
Sbjct: 2406 FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL--- 2462
Query: 1508 NEEAVILPCTQTE-RNLSPSNSCEPKEESQSAPVQKNDSVVSVGT--NNVNTFQQEMKES 1564
+EA +L E + + + + Q + + + DS++ +++ +
Sbjct: 2463 QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2522
Query: 1565 VIQTARQVRGRLQRPRPNIRKTGQRQIVDKGEAK--------GIIKEGRTILPKDE---T 1613
+ A+Q+R QR + + + QR + EA+ G+ ++ + ++
Sbjct: 2523 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2582
Query: 1614 EKKVLTVSNSQIETEIEVPSSAVPEHRMYENQSQVVLVENLHVNKTNETIRH-------E 1666
++++L N ++ ++++ +HR S+ V + KT R E
Sbjct: 2583 QEELLAEENQRLREQLQLLEE---QHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAE 2639
Query: 1667 NKPYVPSSAQMTRRKFQKAKPNLGRAHSKKEEPVLEKVTTDQSKEGKPED--HLLQKGAS 1724
+P S RRK + S +E L + T + + ED H LQ +S
Sbjct: 2640 AEP--EHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSS 2697
Query: 1725 NTQLLLKEKAELLT 1738
LLLK E L+
Sbjct: 2698 IAGLLLKATNEKLS 2711
Score = 68.9 bits (167), Expect = 6e-11
Identities = 233/1260 (18%), Positives = 491/1260 (38%), Gaps = 203/1260 (16%)
Query: 326 GQLFPHRARIEIKNKFKREEKTNGWRIDKAFQEKRPFDFDFFAHLLQKVLAEEEKRKQKS 385
G+L RAR E KR+ + R+ + Q++ L +V AE E ++K
Sbjct: 1473 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1532
Query: 386 VKNHSLKE-----KKSTKPRKNVKVKK-----VACEGVNNDPD-ESMSSRISDTERSQKD 434
+L+E +++ + + +V++ VA E + E S R S E++ +
Sbjct: 1533 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1592
Query: 435 AQTVEEESLTLS--REDAEQVALEVDLNQKKRRRKKQDGANELGVNNLLENATVQAGPSK 492
++++EE + ++ RE+AE+ A + Q + R +++ EL L N
Sbjct: 1593 ERSLQEEHVAVAQLREEAERRAQQ----QAEAERAREEAERELERWQLKAN--------- 1639
Query: 493 GEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGIVGFASTEKVEKRTDPILSLSNQQDA 552
+A+R L+ E ++++ L A E +++ + + A
Sbjct: 1640 --------EALRLRLQAEEVAQQKSL------------AQAEAEKQKEEAEREARRRGKA 1679
Query: 553 TSVATESSESSTSDLPSFEVGIRALCEVNNAEGSCIEERNVDLKNNSLEIDQTENVKPML 612
A E + +L R L E + E+ + L+ E +Q E + +L
Sbjct: 1680 EEQAVRQRELAEQELEK----QRQLAEGTAQQRLAAEQELIRLR---AETEQGEQQRQLL 1732
Query: 613 RGRFQRPKPNLSRAGKKSVLSQGKTESESKNSHSKTSV---EKNHVEKDKMNTLDILRME 669
R L R + + + E+E ++ V K E++ +T + +
Sbjct: 1733 EEELAR----LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE----K 1784
Query: 670 TTERENPEAETVSVLGEKNCLQEGSQLKALRPVQVRGRLQKPKPNAGKAAERKEILI--- 726
+ +R EA L E E ++L+AL R R + A + AE + +L
Sbjct: 1785 SKQRLEAEAGRFRELAE-----EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1839
Query: 727 ----------SQEEIGANVEKNENE--------SCADRDTPQHMEDQSRKDFEEEDVILQ 768
++ EI ++ ENE R + Q + D EE L+
Sbjct: 1840 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1899
Query: 769 PEKNDSFQNVQPDEPKVLNECLSVQENNKANKLNQVPILRTRFQKPKPNIGRGTGRREIS 828
+ + + L + V+E ++ L+ F+K G+ E+
Sbjct: 1900 KASDSELERQKGLVEDTLRQRRQVEE--------EILALKASFEK------AAAGKAEL- 1944
Query: 829 SKEEVLEKILVSGEMAAALRETVRLDTSPKEMVPAEINTKEMQSDLKETGRRAISPREKI 888
E L +I + E +E L+ + + + AE + +++ E +++++ E+
Sbjct: 1945 --ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE--ERVQKSLAAEEEA 2000
Query: 889 LDVIDDTIEMETGLKAMG------REICLREKTPEVIDATEEIDKDLEEAGRREISPQKN 942
+E LKA RE +E ++ A E K L+ + +
Sbjct: 2001 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2060
Query: 943 GPEEVKPLGEVETDL--KATGNESSPREKTPEVTDATEEID-------KNLEETGRRKIS 993
+E++ + E + + G + R E +A + + + +EE R K S
Sbjct: 2061 KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQS 2120
Query: 994 PREN---------GPEEVKPVDEMETDLNATGRESSPREKTPEVIDATEEID---LEETE 1041
E E+++ E E A +++ R+K + DA E E+T
Sbjct: 2121 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK--QAADAEMEKHKKFAEQTL 2178
Query: 1042 REVSPQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEVIDAIEEIEIDLEETEREISPQ 1101
R+ + E L ++ L ETD + D + ++ ++ + E R+ S
Sbjct: 2179 RQKAQVEQELTTLR-LQLEETDHQKNLLD-----------EELQRLKAEATEAARQRSQV 2226
Query: 1102 ENGLEEVK----PLGEMQTDLKATGREISPREKTPE---VIDATEEIDKDLEETGRREIS 1154
E L V+ L +++ ++A R + R+K + + E++ + EE R ++
Sbjct: 2227 EEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2286
Query: 1155 PEENGPEEVKPVDEMETDLKTTGREGSSREKTREVIDAAEV-IETDLEETEREISPQENG 1213
+E ++ + E + + E +EK + V +A + E +L + ++E++ ++
Sbjct: 2287 AQE--AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ-- 2342
Query: 1214 PEEVKPVGKMETDLKEIREEISQREKVLAE-FSAIREKEIDLKETGKRDIPIMEKVSGKM 1272
+++ D +++ +++++ + A R++++++ +R + ++S
Sbjct: 2343 ------ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2396
Query: 1273 AVVEE----MEADLKETGKENFRERGSEEICVTEEKVAELKQTGKTDISPREN----ELE 1324
A EE +E G++ R + + VT + E+++ + R ELE
Sbjct: 2397 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2456
Query: 1325 ETSTSRQTDTHLMQSGSNDFSAVPSLDIQNISSEVLSMMHTPVEEKRNSEKEVSSHFSHF 1384
Q + L+Q + S ++Q + E L +++ SEK+ F
Sbjct: 2457 REKEKLQQEAKLLQ--------LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2508
Query: 1385 KISSQTHESDKTEVQGIQSPDVPEQFSDINLSKSLPQEQKPLEIKPAPFVRSRFK-RPKP 1443
E +K +++ + +V + L + ++Q+ +E + V S + R +
Sbjct: 2509 ------IEQEKAKLEQLFQDEVAKA---QQLREEQQRQQQQMEQERQRLVASMEEARRRQ 2559
Query: 1444 NLARAALKRETTESEKYIYEKKSETKKMETIVMQEN---NEQTDTLPSQHDEASLMISRE 1500
+ A ++R+ E + + + + ++ E ++ +EN EQ L QH A+L S E
Sbjct: 2560 HEAEEGVRRKQEE----LQQLEQQRRQQEELLAEENQRLREQLQLLEEQH-RAALAHSEE 2614
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 75.1 bits (183), Expect = 9e-13
Identities = 297/1514 (19%), Positives = 566/1514 (37%), Gaps = 279/1514 (18%)
Query: 366 FFAHLLQKVLAEEEKR---KQKSVKNHSLKEKKSTKPRKNVKVK-----KVACEGVNNDP 417
F + L+++ EEE+R +Q++ + L E ++ ++ + K E +
Sbjct: 1304 FISETLRRM--EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1361
Query: 418 DESMSSRISDTERSQKDAQ----TVEEESLTLSREDAEQV---ALEVDLNQKKRRRKKQD 470
+ M + E + DAQ +++EE L + ++ A + + ++ R R ++
Sbjct: 1362 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE- 1420
Query: 471 GANELGVNNL-LENATVQAGPSKGEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGIVG 529
E+ V L LE Q G ++GE QA+R +E E K Q + + V
Sbjct: 1421 ---EIRVVRLQLEATERQRGGAEGE-----LQALRARAEEAEAQKRQAQEEAERLRRQVQ 1472
Query: 530 FASTEKVEKRTDPILSLSNQQDATSVATESSESSTSDLPSFEVGIRALCEVNNAEGSCIE 589
S K + + L+++ A + A + + ++AL E+ ++
Sbjct: 1473 DESQRKRQAEVE----LASRVKAEAEAAREKQRA----------LQALEELR------LQ 1512
Query: 590 ERNVDLKNNSLEIDQTENVKPMLRGRFQRPKPNLSRAGKKSVLSQGKTESESKNSHSKTS 649
+ + E+++ V+ L ++ ++ L + K + + S
Sbjct: 1513 AEEAERRLRQAEVERARQVQVALE---------TAQRSAEAELQSKRASFAEKTAQLERS 1563
Query: 650 VEKNHVEKDKMNTLDILRMETTERENPEAETVSVLGEKNCLQEGSQLKALRPVQVR---- 705
+++ HV + LR E R +AE E E QLKA +++R
Sbjct: 1564 LQEEHVAVAQ------LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1617
Query: 706 ----------GRLQKPKPNAGKAAERK----EILISQEEIGANVEKNENESCADRDTPQH 751
+K K A + A R+ E + Q E+ A E + A+ Q
Sbjct: 1618 EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL-AEQELEKQRQLAEGTAQQR 1676
Query: 752 ME---------------DQSRKDFEEEDVILQPEKNDSFQNVQPDEPKVLNECLSVQENN 796
+ +Q R+ EEE LQ E + Q Q E + L + + E
Sbjct: 1677 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE-LAKVRAEMEVL 1735
Query: 797 KANKLNQVPILRTRFQKPKPNIGRGTGR-REISSKEEVLEKIL----------------- 838
A+K R+ +K K + GR RE++ + L +
Sbjct: 1736 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ 1795
Query: 839 ------VSGEMAAALRETVRLDTSPKEMVPAEINTKEMQSDLKETGR----RAISPREKI 888
V E AA+ E RL T AEI KE +++ + R A R
Sbjct: 1796 RAEAERVLAEKLAAIGEATRLKTE------AEIALKEKEAENERLRRLAEDEAFQRRRLE 1849
Query: 889 LDVIDDTIEMETGL----KAMGREICLREKTPEVIDATEEIDKDLEE------------- 931
++E L KA E+ E+ +++ T + +EE
Sbjct: 1850 EQAAQHKADIEERLAQLRKASDSEL---ERQKGLVEDTLRQRRQVEEEILALKASFEKAA 1906
Query: 932 AGRREISPQ-----KNGPEEVKPLGEVETDLKATGNESSPREKTPEVTDATEEIDKNL-- 984
AG+ E+ + N + ++ + + +L+A E+ +A E + K+L
Sbjct: 1907 AGKAELELELGRIRSNAEDTLR--SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 1964
Query: 985 -EETGRRKISPRENGPEEVKPVDEMETDLNATGRESSPREKTPEVIDATEEIDLEETERE 1043
EE R++ + E E +K E L + S R+ A + + EE
Sbjct: 1965 EEEAARQRKAALEE-VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA 2023
Query: 1044 VSPQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEVIDAIEEIEIDLEETEREISPQEN 1103
+ Q+ E + L + ++ L RG+ A EE E + ERE +
Sbjct: 2024 FAVQQKEQELQQTLQQEQSVLDQL------RGEAEAARRAAEEAEEARVQAEREAAQSRR 2077
Query: 1104 GLEEVKPL---GEMQTDLKATGREISPREKTPEVIDATEEIDKDLEETGRREISPEENGP 1160
+EE + L E Q +A + A E++ K+ E+ R E+
Sbjct: 2078 QVEEAERLKQSAEEQAQARAQAQA------------AAEKLRKEAEQEAARRAQAEQAAL 2125
Query: 1161 EEVKPVD-EMETDLKTTGREGSSREKTREVIDAAEVIETDLEETEREISPQENGPEEVKP 1219
+ + D EME K E + R+K +V + LEET+ + + + + +K
Sbjct: 2126 RQKQAADAEMEKHKKFA--EQTLRQKA-QVEQELTTLRLQLEETDHQKNLLDEELQRLKA 2182
Query: 1220 VGKMETDLKEIREEISQREKVLAEFSAIREKEIDLK------ETGKRDIPIMEKVSGKMA 1273
E E QR +V E ++R + +L E R + + +K + +
Sbjct: 2183 ---------EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF 2233
Query: 1274 VVEEMEADLKETGKENFRERGSEEICVTEEKVAELKQTGKTDISPR----ENELEETSTS 1329
+ EE E +K+ +E R + V ++ A L+Q + D++ + E L+E +
Sbjct: 2234 LQEEAEK-MKQVAEEAAR------LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA 2286
Query: 1330 RQTDTHLMQSGSNDFSAVPSLDIQNISSEVLSMMHTPVEEKRNSEKEVSSHFSHFKISSQ 1389
Q T L +E+L +E+ +E +++ Q
Sbjct: 2287 VQEATRL-----------------KAEAELLQQQKELAQEQARRLQEDKE-----QMAQQ 2324
Query: 1390 THESDKTEVQGIQSPDVPEQFSDINLSKSLPQEQKPLEIKPAPFVRSRFKRPKPNLARAA 1449
E E QG Q E+ + +S E + L+++ A R++ R + + R
Sbjct: 2325 LAE----ETQGFQRTLEAERQRQLEMSA----EAERLKLRVAEMSRAQ-ARAEEDAQR-- 2373
Query: 1450 LKRETTESEKYIYEKKSETKKMETIV--MQENNEQTDTLPSQHDEASLMISREKDTLGHR 1507
+++ E + ++ + T++ T+V ++ +Q+D + EA + REK+ L
Sbjct: 2374 FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL--- 2430
Query: 1508 NEEAVILPCTQTE-RNLSPSNSCEPKEESQSAPVQKNDSVVSVGT--NNVNTFQQEMKES 1564
+EA +L E + + + + Q + + + DS++ +++ +
Sbjct: 2431 QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2490
Query: 1565 VIQTARQVRGRLQRPRPNIRKTGQRQIVDKGEAK--------GIIKEGRTILPKDE---T 1613
+ A+Q+R QR + + + QR + EA+ G+ ++ + ++
Sbjct: 2491 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2550
Query: 1614 EKKVLTVSNSQIETEIEVPSSAVPEHRMYENQSQVVLVENLHVNKTNETIRH-------E 1666
++++L N ++ ++++ +HR S+ V + KT R E
Sbjct: 2551 QEELLAEENQRLREQLQLLEE---QHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAE 2607
Query: 1667 NKPYVPSSAQMTRRKFQKAKPNLGRAHSKKEEPVLEKVTTDQSKEGKPED--HLLQKGAS 1724
+P S RRK + S +E L + T + + ED H LQ +S
Sbjct: 2608 AEP--EHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSS 2665
Query: 1725 NTQLLLKEKAELLT 1738
LLLK E L+
Sbjct: 2666 IAGLLLKATNEKLS 2679
Score = 68.9 bits (167), Expect = 6e-11
Identities = 233/1260 (18%), Positives = 491/1260 (38%), Gaps = 203/1260 (16%)
Query: 326 GQLFPHRARIEIKNKFKREEKTNGWRIDKAFQEKRPFDFDFFAHLLQKVLAEEEKRKQKS 385
G+L RAR E KR+ + R+ + Q++ L +V AE E ++K
Sbjct: 1441 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1500
Query: 386 VKNHSLKE-----KKSTKPRKNVKVKK-----VACEGVNNDPD-ESMSSRISDTERSQKD 434
+L+E +++ + + +V++ VA E + E S R S E++ +
Sbjct: 1501 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1560
Query: 435 AQTVEEESLTLS--REDAEQVALEVDLNQKKRRRKKQDGANELGVNNLLENATVQAGPSK 492
++++EE + ++ RE+AE+ A + Q + R +++ EL L N
Sbjct: 1561 ERSLQEEHVAVAQLREEAERRAQQ----QAEAERAREEAERELERWQLKAN--------- 1607
Query: 493 GEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGIVGFASTEKVEKRTDPILSLSNQQDA 552
+A+R L+ E ++++ L A E +++ + + A
Sbjct: 1608 --------EALRLRLQAEEVAQQKSL------------AQAEAEKQKEEAEREARRRGKA 1647
Query: 553 TSVATESSESSTSDLPSFEVGIRALCEVNNAEGSCIEERNVDLKNNSLEIDQTENVKPML 612
A E + +L R L E + E+ + L+ E +Q E + +L
Sbjct: 1648 EEQAVRQRELAEQELEK----QRQLAEGTAQQRLAAEQELIRLR---AETEQGEQQRQLL 1700
Query: 613 RGRFQRPKPNLSRAGKKSVLSQGKTESESKNSHSKTSV---EKNHVEKDKMNTLDILRME 669
R L R + + + E+E ++ V K E++ +T + +
Sbjct: 1701 EEELAR----LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE----K 1752
Query: 670 TTERENPEAETVSVLGEKNCLQEGSQLKALRPVQVRGRLQKPKPNAGKAAERKEILI--- 726
+ +R EA L E E ++L+AL R R + A + AE + +L
Sbjct: 1753 SKQRLEAEAGRFRELAE-----EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1807
Query: 727 ----------SQEEIGANVEKNENE--------SCADRDTPQHMEDQSRKDFEEEDVILQ 768
++ EI ++ ENE R + Q + D EE L+
Sbjct: 1808 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1867
Query: 769 PEKNDSFQNVQPDEPKVLNECLSVQENNKANKLNQVPILRTRFQKPKPNIGRGTGRREIS 828
+ + + L + V+E ++ L+ F+K G+ E+
Sbjct: 1868 KASDSELERQKGLVEDTLRQRRQVEE--------EILALKASFEK------AAAGKAEL- 1912
Query: 829 SKEEVLEKILVSGEMAAALRETVRLDTSPKEMVPAEINTKEMQSDLKETGRRAISPREKI 888
E L +I + E +E L+ + + + AE + +++ E +++++ E+
Sbjct: 1913 --ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE--ERVQKSLAAEEEA 1968
Query: 889 LDVIDDTIEMETGLKAMG------REICLREKTPEVIDATEEIDKDLEEAGRREISPQKN 942
+E LKA RE +E ++ A E K L+ + +
Sbjct: 1969 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2028
Query: 943 GPEEVKPLGEVETDL--KATGNESSPREKTPEVTDATEEID-------KNLEETGRRKIS 993
+E++ + E + + G + R E +A + + + +EE R K S
Sbjct: 2029 KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQS 2088
Query: 994 PREN---------GPEEVKPVDEMETDLNATGRESSPREKTPEVIDATEEID---LEETE 1041
E E+++ E E A +++ R+K + DA E E+T
Sbjct: 2089 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK--QAADAEMEKHKKFAEQTL 2146
Query: 1042 REVSPQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEVIDAIEEIEIDLEETEREISPQ 1101
R+ + E L ++ L ETD + D + ++ ++ + E R+ S
Sbjct: 2147 RQKAQVEQELTTLR-LQLEETDHQKNLLD-----------EELQRLKAEATEAARQRSQV 2194
Query: 1102 ENGLEEVK----PLGEMQTDLKATGREISPREKTPE---VIDATEEIDKDLEETGRREIS 1154
E L V+ L +++ ++A R + R+K + + E++ + EE R ++
Sbjct: 2195 EEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2254
Query: 1155 PEENGPEEVKPVDEMETDLKTTGREGSSREKTREVIDAAEV-IETDLEETEREISPQENG 1213
+E ++ + E + + E +EK + V +A + E +L + ++E++ ++
Sbjct: 2255 AQE--AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ-- 2310
Query: 1214 PEEVKPVGKMETDLKEIREEISQREKVLAE-FSAIREKEIDLKETGKRDIPIMEKVSGKM 1272
+++ D +++ +++++ + A R++++++ +R + ++S
Sbjct: 2311 ------ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2364
Query: 1273 AVVEE----MEADLKETGKENFRERGSEEICVTEEKVAELKQTGKTDISPREN----ELE 1324
A EE +E G++ R + + VT + E+++ + R ELE
Sbjct: 2365 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2424
Query: 1325 ETSTSRQTDTHLMQSGSNDFSAVPSLDIQNISSEVLSMMHTPVEEKRNSEKEVSSHFSHF 1384
Q + L+Q + S ++Q + E L +++ SEK+ F
Sbjct: 2425 REKEKLQQEAKLLQ--------LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2476
Query: 1385 KISSQTHESDKTEVQGIQSPDVPEQFSDINLSKSLPQEQKPLEIKPAPFVRSRFK-RPKP 1443
E +K +++ + +V + L + ++Q+ +E + V S + R +
Sbjct: 2477 ------IEQEKAKLEQLFQDEVAKA---QQLREEQQRQQQQMEQERQRLVASMEEARRRQ 2527
Query: 1444 NLARAALKRETTESEKYIYEKKSETKKMETIVMQEN---NEQTDTLPSQHDEASLMISRE 1500
+ A ++R+ E + + + + ++ E ++ +EN EQ L QH A+L S E
Sbjct: 2528 HEAEEGVRRKQEE----LQQLEQQRRQQEELLAEENQRLREQLQLLEEQH-RAALAHSEE 2582
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 75.1 bits (183), Expect = 9e-13
Identities = 297/1514 (19%), Positives = 566/1514 (37%), Gaps = 279/1514 (18%)
Query: 366 FFAHLLQKVLAEEEKR---KQKSVKNHSLKEKKSTKPRKNVKVK-----KVACEGVNNDP 417
F + L+++ EEE+R +Q++ + L E ++ ++ + K E +
Sbjct: 1473 FISETLRRM--EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1530
Query: 418 DESMSSRISDTERSQKDAQ----TVEEESLTLSREDAEQV---ALEVDLNQKKRRRKKQD 470
+ M + E + DAQ +++EE L + ++ A + + ++ R R ++
Sbjct: 1531 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE- 1589
Query: 471 GANELGVNNL-LENATVQAGPSKGEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGIVG 529
E+ V L LE Q G ++GE QA+R +E E K Q + + V
Sbjct: 1590 ---EIRVVRLQLEATERQRGGAEGE-----LQALRARAEEAEAQKRQAQEEAERLRRQVQ 1641
Query: 530 FASTEKVEKRTDPILSLSNQQDATSVATESSESSTSDLPSFEVGIRALCEVNNAEGSCIE 589
S K + + L+++ A + A + + ++AL E+ ++
Sbjct: 1642 DESQRKRQAEVE----LASRVKAEAEAAREKQRA----------LQALEELR------LQ 1681
Query: 590 ERNVDLKNNSLEIDQTENVKPMLRGRFQRPKPNLSRAGKKSVLSQGKTESESKNSHSKTS 649
+ + E+++ V+ L ++ ++ L + K + + S
Sbjct: 1682 AEEAERRLRQAEVERARQVQVALE---------TAQRSAEAELQSKRASFAEKTAQLERS 1732
Query: 650 VEKNHVEKDKMNTLDILRMETTERENPEAETVSVLGEKNCLQEGSQLKALRPVQVR---- 705
+++ HV + LR E R +AE E E QLKA +++R
Sbjct: 1733 LQEEHVAVAQ------LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1786
Query: 706 ----------GRLQKPKPNAGKAAERK----EILISQEEIGANVEKNENESCADRDTPQH 751
+K K A + A R+ E + Q E+ A E + A+ Q
Sbjct: 1787 EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL-AEQELEKQRQLAEGTAQQR 1845
Query: 752 ME---------------DQSRKDFEEEDVILQPEKNDSFQNVQPDEPKVLNECLSVQENN 796
+ +Q R+ EEE LQ E + Q Q E + L + + E
Sbjct: 1846 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE-LAKVRAEMEVL 1904
Query: 797 KANKLNQVPILRTRFQKPKPNIGRGTGR-REISSKEEVLEKIL----------------- 838
A+K R+ +K K + GR RE++ + L +
Sbjct: 1905 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ 1964
Query: 839 ------VSGEMAAALRETVRLDTSPKEMVPAEINTKEMQSDLKETGR----RAISPREKI 888
V E AA+ E RL T AEI KE +++ + R A R
Sbjct: 1965 RAEAERVLAEKLAAIGEATRLKTE------AEIALKEKEAENERLRRLAEDEAFQRRRLE 2018
Query: 889 LDVIDDTIEMETGL----KAMGREICLREKTPEVIDATEEIDKDLEE------------- 931
++E L KA E+ E+ +++ T + +EE
Sbjct: 2019 EQAAQHKADIEERLAQLRKASDSEL---ERQKGLVEDTLRQRRQVEEEILALKASFEKAA 2075
Query: 932 AGRREISPQ-----KNGPEEVKPLGEVETDLKATGNESSPREKTPEVTDATEEIDKNL-- 984
AG+ E+ + N + ++ + + +L+A E+ +A E + K+L
Sbjct: 2076 AGKAELELELGRIRSNAEDTLR--SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 2133
Query: 985 -EETGRRKISPRENGPEEVKPVDEMETDLNATGRESSPREKTPEVIDATEEIDLEETERE 1043
EE R++ + E E +K E L + S R+ A + + EE
Sbjct: 2134 EEEAARQRKAALEE-VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA 2192
Query: 1044 VSPQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEVIDAIEEIEIDLEETEREISPQEN 1103
+ Q+ E + L + ++ L RG+ A EE E + ERE +
Sbjct: 2193 FAVQQKEQELQQTLQQEQSVLDQL------RGEAEAARRAAEEAEEARVQAEREAAQSRR 2246
Query: 1104 GLEEVKPL---GEMQTDLKATGREISPREKTPEVIDATEEIDKDLEETGRREISPEENGP 1160
+EE + L E Q +A + A E++ K+ E+ R E+
Sbjct: 2247 QVEEAERLKQSAEEQAQARAQAQA------------AAEKLRKEAEQEAARRAQAEQAAL 2294
Query: 1161 EEVKPVD-EMETDLKTTGREGSSREKTREVIDAAEVIETDLEETEREISPQENGPEEVKP 1219
+ + D EME K E + R+K +V + LEET+ + + + + +K
Sbjct: 2295 RQKQAADAEMEKHKKFA--EQTLRQKA-QVEQELTTLRLQLEETDHQKNLLDEELQRLKA 2351
Query: 1220 VGKMETDLKEIREEISQREKVLAEFSAIREKEIDLK------ETGKRDIPIMEKVSGKMA 1273
E E QR +V E ++R + +L E R + + +K + +
Sbjct: 2352 ---------EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF 2402
Query: 1274 VVEEMEADLKETGKENFRERGSEEICVTEEKVAELKQTGKTDISPR----ENELEETSTS 1329
+ EE E +K+ +E R + V ++ A L+Q + D++ + E L+E +
Sbjct: 2403 LQEEAEK-MKQVAEEAAR------LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA 2455
Query: 1330 RQTDTHLMQSGSNDFSAVPSLDIQNISSEVLSMMHTPVEEKRNSEKEVSSHFSHFKISSQ 1389
Q T L +E+L +E+ +E +++ Q
Sbjct: 2456 VQEATRL-----------------KAEAELLQQQKELAQEQARRLQEDKE-----QMAQQ 2493
Query: 1390 THESDKTEVQGIQSPDVPEQFSDINLSKSLPQEQKPLEIKPAPFVRSRFKRPKPNLARAA 1449
E E QG Q E+ + +S E + L+++ A R++ R + + R
Sbjct: 2494 LAE----ETQGFQRTLEAERQRQLEMSA----EAERLKLRVAEMSRAQ-ARAEEDAQR-- 2542
Query: 1450 LKRETTESEKYIYEKKSETKKMETIV--MQENNEQTDTLPSQHDEASLMISREKDTLGHR 1507
+++ E + ++ + T++ T+V ++ +Q+D + EA + REK+ L
Sbjct: 2543 FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL--- 2599
Query: 1508 NEEAVILPCTQTE-RNLSPSNSCEPKEESQSAPVQKNDSVVSVGT--NNVNTFQQEMKES 1564
+EA +L E + + + + Q + + + DS++ +++ +
Sbjct: 2600 QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2659
Query: 1565 VIQTARQVRGRLQRPRPNIRKTGQRQIVDKGEAK--------GIIKEGRTILPKDE---T 1613
+ A+Q+R QR + + + QR + EA+ G+ ++ + ++
Sbjct: 2660 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2719
Query: 1614 EKKVLTVSNSQIETEIEVPSSAVPEHRMYENQSQVVLVENLHVNKTNETIRH-------E 1666
++++L N ++ ++++ +HR S+ V + KT R E
Sbjct: 2720 QEELLAEENQRLREQLQLLEE---QHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAE 2776
Query: 1667 NKPYVPSSAQMTRRKFQKAKPNLGRAHSKKEEPVLEKVTTDQSKEGKPED--HLLQKGAS 1724
+P S RRK + S +E L + T + + ED H LQ +S
Sbjct: 2777 AEP--EHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSS 2834
Query: 1725 NTQLLLKEKAELLT 1738
LLLK E L+
Sbjct: 2835 IAGLLLKATNEKLS 2848
Score = 68.9 bits (167), Expect = 6e-11
Identities = 233/1260 (18%), Positives = 491/1260 (38%), Gaps = 203/1260 (16%)
Query: 326 GQLFPHRARIEIKNKFKREEKTNGWRIDKAFQEKRPFDFDFFAHLLQKVLAEEEKRKQKS 385
G+L RAR E KR+ + R+ + Q++ L +V AE E ++K
Sbjct: 1610 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1669
Query: 386 VKNHSLKE-----KKSTKPRKNVKVKK-----VACEGVNNDPD-ESMSSRISDTERSQKD 434
+L+E +++ + + +V++ VA E + E S R S E++ +
Sbjct: 1670 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1729
Query: 435 AQTVEEESLTLS--REDAEQVALEVDLNQKKRRRKKQDGANELGVNNLLENATVQAGPSK 492
++++EE + ++ RE+AE+ A + Q + R +++ EL L N
Sbjct: 1730 ERSLQEEHVAVAQLREEAERRAQQ----QAEAERAREEAERELERWQLKAN--------- 1776
Query: 493 GEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGIVGFASTEKVEKRTDPILSLSNQQDA 552
+A+R L+ E ++++ L A E +++ + + A
Sbjct: 1777 --------EALRLRLQAEEVAQQKSL------------AQAEAEKQKEEAEREARRRGKA 1816
Query: 553 TSVATESSESSTSDLPSFEVGIRALCEVNNAEGSCIEERNVDLKNNSLEIDQTENVKPML 612
A E + +L R L E + E+ + L+ E +Q E + +L
Sbjct: 1817 EEQAVRQRELAEQELEK----QRQLAEGTAQQRLAAEQELIRLR---AETEQGEQQRQLL 1869
Query: 613 RGRFQRPKPNLSRAGKKSVLSQGKTESESKNSHSKTSV---EKNHVEKDKMNTLDILRME 669
R L R + + + E+E ++ V K E++ +T + +
Sbjct: 1870 EEELAR----LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE----K 1921
Query: 670 TTERENPEAETVSVLGEKNCLQEGSQLKALRPVQVRGRLQKPKPNAGKAAERKEILI--- 726
+ +R EA L E E ++L+AL R R + A + AE + +L
Sbjct: 1922 SKQRLEAEAGRFRELAE-----EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1976
Query: 727 ----------SQEEIGANVEKNENE--------SCADRDTPQHMEDQSRKDFEEEDVILQ 768
++ EI ++ ENE R + Q + D EE L+
Sbjct: 1977 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 2036
Query: 769 PEKNDSFQNVQPDEPKVLNECLSVQENNKANKLNQVPILRTRFQKPKPNIGRGTGRREIS 828
+ + + L + V+E ++ L+ F+K G+ E+
Sbjct: 2037 KASDSELERQKGLVEDTLRQRRQVEE--------EILALKASFEK------AAAGKAEL- 2081
Query: 829 SKEEVLEKILVSGEMAAALRETVRLDTSPKEMVPAEINTKEMQSDLKETGRRAISPREKI 888
E L +I + E +E L+ + + + AE + +++ E +++++ E+
Sbjct: 2082 --ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE--ERVQKSLAAEEEA 2137
Query: 889 LDVIDDTIEMETGLKAMG------REICLREKTPEVIDATEEIDKDLEEAGRREISPQKN 942
+E LKA RE +E ++ A E K L+ + +
Sbjct: 2138 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2197
Query: 943 GPEEVKPLGEVETDL--KATGNESSPREKTPEVTDATEEID-------KNLEETGRRKIS 993
+E++ + E + + G + R E +A + + + +EE R K S
Sbjct: 2198 KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQS 2257
Query: 994 PREN---------GPEEVKPVDEMETDLNATGRESSPREKTPEVIDATEEID---LEETE 1041
E E+++ E E A +++ R+K + DA E E+T
Sbjct: 2258 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK--QAADAEMEKHKKFAEQTL 2315
Query: 1042 REVSPQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEVIDAIEEIEIDLEETEREISPQ 1101
R+ + E L ++ L ETD + D + ++ ++ + E R+ S
Sbjct: 2316 RQKAQVEQELTTLR-LQLEETDHQKNLLD-----------EELQRLKAEATEAARQRSQV 2363
Query: 1102 ENGLEEVK----PLGEMQTDLKATGREISPREKTPE---VIDATEEIDKDLEETGRREIS 1154
E L V+ L +++ ++A R + R+K + + E++ + EE R ++
Sbjct: 2364 EEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2423
Query: 1155 PEENGPEEVKPVDEMETDLKTTGREGSSREKTREVIDAAEV-IETDLEETEREISPQENG 1213
+E ++ + E + + E +EK + V +A + E +L + ++E++ ++
Sbjct: 2424 AQE--AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ-- 2479
Query: 1214 PEEVKPVGKMETDLKEIREEISQREKVLAE-FSAIREKEIDLKETGKRDIPIMEKVSGKM 1272
+++ D +++ +++++ + A R++++++ +R + ++S
Sbjct: 2480 ------ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2533
Query: 1273 AVVEE----MEADLKETGKENFRERGSEEICVTEEKVAELKQTGKTDISPREN----ELE 1324
A EE +E G++ R + + VT + E+++ + R ELE
Sbjct: 2534 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2593
Query: 1325 ETSTSRQTDTHLMQSGSNDFSAVPSLDIQNISSEVLSMMHTPVEEKRNSEKEVSSHFSHF 1384
Q + L+Q + S ++Q + E L +++ SEK+ F
Sbjct: 2594 REKEKLQQEAKLLQ--------LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2645
Query: 1385 KISSQTHESDKTEVQGIQSPDVPEQFSDINLSKSLPQEQKPLEIKPAPFVRSRFK-RPKP 1443
E +K +++ + +V + L + ++Q+ +E + V S + R +
Sbjct: 2646 ------IEQEKAKLEQLFQDEVAKA---QQLREEQQRQQQQMEQERQRLVASMEEARRRQ 2696
Query: 1444 NLARAALKRETTESEKYIYEKKSETKKMETIVMQEN---NEQTDTLPSQHDEASLMISRE 1500
+ A ++R+ E + + + + ++ E ++ +EN EQ L QH A+L S E
Sbjct: 2697 HEAEEGVRRKQEE----LQQLEQQRRQQEELLAEENQRLREQLQLLEEQH-RAALAHSEE 2751
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 75.1 bits (183), Expect = 9e-13
Identities = 297/1514 (19%), Positives = 566/1514 (37%), Gaps = 279/1514 (18%)
Query: 366 FFAHLLQKVLAEEEKR---KQKSVKNHSLKEKKSTKPRKNVKVK-----KVACEGVNNDP 417
F + L+++ EEE+R +Q++ + L E ++ ++ + K E +
Sbjct: 1314 FISETLRRM--EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1371
Query: 418 DESMSSRISDTERSQKDAQ----TVEEESLTLSREDAEQV---ALEVDLNQKKRRRKKQD 470
+ M + E + DAQ +++EE L + ++ A + + ++ R R ++
Sbjct: 1372 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE- 1430
Query: 471 GANELGVNNL-LENATVQAGPSKGEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGIVG 529
E+ V L LE Q G ++GE QA+R +E E K Q + + V
Sbjct: 1431 ---EIRVVRLQLEATERQRGGAEGE-----LQALRARAEEAEAQKRQAQEEAERLRRQVQ 1482
Query: 530 FASTEKVEKRTDPILSLSNQQDATSVATESSESSTSDLPSFEVGIRALCEVNNAEGSCIE 589
S K + + L+++ A + A + + ++AL E+ ++
Sbjct: 1483 DESQRKRQAEVE----LASRVKAEAEAAREKQRA----------LQALEELR------LQ 1522
Query: 590 ERNVDLKNNSLEIDQTENVKPMLRGRFQRPKPNLSRAGKKSVLSQGKTESESKNSHSKTS 649
+ + E+++ V+ L ++ ++ L + K + + S
Sbjct: 1523 AEEAERRLRQAEVERARQVQVALE---------TAQRSAEAELQSKRASFAEKTAQLERS 1573
Query: 650 VEKNHVEKDKMNTLDILRMETTERENPEAETVSVLGEKNCLQEGSQLKALRPVQVR---- 705
+++ HV + LR E R +AE E E QLKA +++R
Sbjct: 1574 LQEEHVAVAQ------LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1627
Query: 706 ----------GRLQKPKPNAGKAAERK----EILISQEEIGANVEKNENESCADRDTPQH 751
+K K A + A R+ E + Q E+ A E + A+ Q
Sbjct: 1628 EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL-AEQELEKQRQLAEGTAQQR 1686
Query: 752 ME---------------DQSRKDFEEEDVILQPEKNDSFQNVQPDEPKVLNECLSVQENN 796
+ +Q R+ EEE LQ E + Q Q E + L + + E
Sbjct: 1687 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE-LAKVRAEMEVL 1745
Query: 797 KANKLNQVPILRTRFQKPKPNIGRGTGR-REISSKEEVLEKIL----------------- 838
A+K R+ +K K + GR RE++ + L +
Sbjct: 1746 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ 1805
Query: 839 ------VSGEMAAALRETVRLDTSPKEMVPAEINTKEMQSDLKETGR----RAISPREKI 888
V E AA+ E RL T AEI KE +++ + R A R
Sbjct: 1806 RAEAERVLAEKLAAIGEATRLKTE------AEIALKEKEAENERLRRLAEDEAFQRRRLE 1859
Query: 889 LDVIDDTIEMETGL----KAMGREICLREKTPEVIDATEEIDKDLEE------------- 931
++E L KA E+ E+ +++ T + +EE
Sbjct: 1860 EQAAQHKADIEERLAQLRKASDSEL---ERQKGLVEDTLRQRRQVEEEILALKASFEKAA 1916
Query: 932 AGRREISPQ-----KNGPEEVKPLGEVETDLKATGNESSPREKTPEVTDATEEIDKNL-- 984
AG+ E+ + N + ++ + + +L+A E+ +A E + K+L
Sbjct: 1917 AGKAELELELGRIRSNAEDTLR--SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 1974
Query: 985 -EETGRRKISPRENGPEEVKPVDEMETDLNATGRESSPREKTPEVIDATEEIDLEETERE 1043
EE R++ + E E +K E L + S R+ A + + EE
Sbjct: 1975 EEEAARQRKAALEE-VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA 2033
Query: 1044 VSPQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEVIDAIEEIEIDLEETEREISPQEN 1103
+ Q+ E + L + ++ L RG+ A EE E + ERE +
Sbjct: 2034 FAVQQKEQELQQTLQQEQSVLDQL------RGEAEAARRAAEEAEEARVQAEREAAQSRR 2087
Query: 1104 GLEEVKPL---GEMQTDLKATGREISPREKTPEVIDATEEIDKDLEETGRREISPEENGP 1160
+EE + L E Q +A + A E++ K+ E+ R E+
Sbjct: 2088 QVEEAERLKQSAEEQAQARAQAQA------------AAEKLRKEAEQEAARRAQAEQAAL 2135
Query: 1161 EEVKPVD-EMETDLKTTGREGSSREKTREVIDAAEVIETDLEETEREISPQENGPEEVKP 1219
+ + D EME K E + R+K +V + LEET+ + + + + +K
Sbjct: 2136 RQKQAADAEMEKHKKFA--EQTLRQKA-QVEQELTTLRLQLEETDHQKNLLDEELQRLKA 2192
Query: 1220 VGKMETDLKEIREEISQREKVLAEFSAIREKEIDLK------ETGKRDIPIMEKVSGKMA 1273
E E QR +V E ++R + +L E R + + +K + +
Sbjct: 2193 ---------EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF 2243
Query: 1274 VVEEMEADLKETGKENFRERGSEEICVTEEKVAELKQTGKTDISPR----ENELEETSTS 1329
+ EE E +K+ +E R + V ++ A L+Q + D++ + E L+E +
Sbjct: 2244 LQEEAEK-MKQVAEEAAR------LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA 2296
Query: 1330 RQTDTHLMQSGSNDFSAVPSLDIQNISSEVLSMMHTPVEEKRNSEKEVSSHFSHFKISSQ 1389
Q T L +E+L +E+ +E +++ Q
Sbjct: 2297 VQEATRL-----------------KAEAELLQQQKELAQEQARRLQEDKE-----QMAQQ 2334
Query: 1390 THESDKTEVQGIQSPDVPEQFSDINLSKSLPQEQKPLEIKPAPFVRSRFKRPKPNLARAA 1449
E E QG Q E+ + +S E + L+++ A R++ R + + R
Sbjct: 2335 LAE----ETQGFQRTLEAERQRQLEMSA----EAERLKLRVAEMSRAQ-ARAEEDAQR-- 2383
Query: 1450 LKRETTESEKYIYEKKSETKKMETIV--MQENNEQTDTLPSQHDEASLMISREKDTLGHR 1507
+++ E + ++ + T++ T+V ++ +Q+D + EA + REK+ L
Sbjct: 2384 FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL--- 2440
Query: 1508 NEEAVILPCTQTE-RNLSPSNSCEPKEESQSAPVQKNDSVVSVGT--NNVNTFQQEMKES 1564
+EA +L E + + + + Q + + + DS++ +++ +
Sbjct: 2441 QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2500
Query: 1565 VIQTARQVRGRLQRPRPNIRKTGQRQIVDKGEAK--------GIIKEGRTILPKDE---T 1613
+ A+Q+R QR + + + QR + EA+ G+ ++ + ++
Sbjct: 2501 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2560
Query: 1614 EKKVLTVSNSQIETEIEVPSSAVPEHRMYENQSQVVLVENLHVNKTNETIRH-------E 1666
++++L N ++ ++++ +HR S+ V + KT R E
Sbjct: 2561 QEELLAEENQRLREQLQLLEE---QHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAE 2617
Query: 1667 NKPYVPSSAQMTRRKFQKAKPNLGRAHSKKEEPVLEKVTTDQSKEGKPED--HLLQKGAS 1724
+P S RRK + S +E L + T + + ED H LQ +S
Sbjct: 2618 AEP--EHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSS 2675
Query: 1725 NTQLLLKEKAELLT 1738
LLLK E L+
Sbjct: 2676 IAGLLLKATNEKLS 2689
Score = 68.9 bits (167), Expect = 6e-11
Identities = 233/1260 (18%), Positives = 491/1260 (38%), Gaps = 203/1260 (16%)
Query: 326 GQLFPHRARIEIKNKFKREEKTNGWRIDKAFQEKRPFDFDFFAHLLQKVLAEEEKRKQKS 385
G+L RAR E KR+ + R+ + Q++ L +V AE E ++K
Sbjct: 1451 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1510
Query: 386 VKNHSLKE-----KKSTKPRKNVKVKK-----VACEGVNNDPD-ESMSSRISDTERSQKD 434
+L+E +++ + + +V++ VA E + E S R S E++ +
Sbjct: 1511 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1570
Query: 435 AQTVEEESLTLS--REDAEQVALEVDLNQKKRRRKKQDGANELGVNNLLENATVQAGPSK 492
++++EE + ++ RE+AE+ A + Q + R +++ EL L N
Sbjct: 1571 ERSLQEEHVAVAQLREEAERRAQQ----QAEAERAREEAERELERWQLKAN--------- 1617
Query: 493 GEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGIVGFASTEKVEKRTDPILSLSNQQDA 552
+A+R L+ E ++++ L A E +++ + + A
Sbjct: 1618 --------EALRLRLQAEEVAQQKSL------------AQAEAEKQKEEAEREARRRGKA 1657
Query: 553 TSVATESSESSTSDLPSFEVGIRALCEVNNAEGSCIEERNVDLKNNSLEIDQTENVKPML 612
A E + +L R L E + E+ + L+ E +Q E + +L
Sbjct: 1658 EEQAVRQRELAEQELEK----QRQLAEGTAQQRLAAEQELIRLR---AETEQGEQQRQLL 1710
Query: 613 RGRFQRPKPNLSRAGKKSVLSQGKTESESKNSHSKTSV---EKNHVEKDKMNTLDILRME 669
R L R + + + E+E ++ V K E++ +T + +
Sbjct: 1711 EEELAR----LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE----K 1762
Query: 670 TTERENPEAETVSVLGEKNCLQEGSQLKALRPVQVRGRLQKPKPNAGKAAERKEILI--- 726
+ +R EA L E E ++L+AL R R + A + AE + +L
Sbjct: 1763 SKQRLEAEAGRFRELAE-----EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1817
Query: 727 ----------SQEEIGANVEKNENE--------SCADRDTPQHMEDQSRKDFEEEDVILQ 768
++ EI ++ ENE R + Q + D EE L+
Sbjct: 1818 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1877
Query: 769 PEKNDSFQNVQPDEPKVLNECLSVQENNKANKLNQVPILRTRFQKPKPNIGRGTGRREIS 828
+ + + L + V+E ++ L+ F+K G+ E+
Sbjct: 1878 KASDSELERQKGLVEDTLRQRRQVEE--------EILALKASFEK------AAAGKAEL- 1922
Query: 829 SKEEVLEKILVSGEMAAALRETVRLDTSPKEMVPAEINTKEMQSDLKETGRRAISPREKI 888
E L +I + E +E L+ + + + AE + +++ E +++++ E+
Sbjct: 1923 --ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE--ERVQKSLAAEEEA 1978
Query: 889 LDVIDDTIEMETGLKAMG------REICLREKTPEVIDATEEIDKDLEEAGRREISPQKN 942
+E LKA RE +E ++ A E K L+ + +
Sbjct: 1979 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2038
Query: 943 GPEEVKPLGEVETDL--KATGNESSPREKTPEVTDATEEID-------KNLEETGRRKIS 993
+E++ + E + + G + R E +A + + + +EE R K S
Sbjct: 2039 KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQS 2098
Query: 994 PREN---------GPEEVKPVDEMETDLNATGRESSPREKTPEVIDATEEID---LEETE 1041
E E+++ E E A +++ R+K + DA E E+T
Sbjct: 2099 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK--QAADAEMEKHKKFAEQTL 2156
Query: 1042 REVSPQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEVIDAIEEIEIDLEETEREISPQ 1101
R+ + E L ++ L ETD + D + ++ ++ + E R+ S
Sbjct: 2157 RQKAQVEQELTTLR-LQLEETDHQKNLLD-----------EELQRLKAEATEAARQRSQV 2204
Query: 1102 ENGLEEVK----PLGEMQTDLKATGREISPREKTPE---VIDATEEIDKDLEETGRREIS 1154
E L V+ L +++ ++A R + R+K + + E++ + EE R ++
Sbjct: 2205 EEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2264
Query: 1155 PEENGPEEVKPVDEMETDLKTTGREGSSREKTREVIDAAEV-IETDLEETEREISPQENG 1213
+E ++ + E + + E +EK + V +A + E +L + ++E++ ++
Sbjct: 2265 AQE--AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ-- 2320
Query: 1214 PEEVKPVGKMETDLKEIREEISQREKVLAE-FSAIREKEIDLKETGKRDIPIMEKVSGKM 1272
+++ D +++ +++++ + A R++++++ +R + ++S
Sbjct: 2321 ------ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2374
Query: 1273 AVVEE----MEADLKETGKENFRERGSEEICVTEEKVAELKQTGKTDISPREN----ELE 1324
A EE +E G++ R + + VT + E+++ + R ELE
Sbjct: 2375 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2434
Query: 1325 ETSTSRQTDTHLMQSGSNDFSAVPSLDIQNISSEVLSMMHTPVEEKRNSEKEVSSHFSHF 1384
Q + L+Q + S ++Q + E L +++ SEK+ F
Sbjct: 2435 REKEKLQQEAKLLQ--------LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2486
Query: 1385 KISSQTHESDKTEVQGIQSPDVPEQFSDINLSKSLPQEQKPLEIKPAPFVRSRFK-RPKP 1443
E +K +++ + +V + L + ++Q+ +E + V S + R +
Sbjct: 2487 ------IEQEKAKLEQLFQDEVAKA---QQLREEQQRQQQQMEQERQRLVASMEEARRRQ 2537
Query: 1444 NLARAALKRETTESEKYIYEKKSETKKMETIVMQEN---NEQTDTLPSQHDEASLMISRE 1500
+ A ++R+ E + + + + ++ E ++ +EN EQ L QH A+L S E
Sbjct: 2538 HEAEEGVRRKQEE----LQQLEQQRRQQEELLAEENQRLREQLQLLEEQH-RAALAHSEE 2592
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 75.1 bits (183), Expect = 9e-13
Identities = 297/1514 (19%), Positives = 566/1514 (37%), Gaps = 279/1514 (18%)
Query: 366 FFAHLLQKVLAEEEKR---KQKSVKNHSLKEKKSTKPRKNVKVK-----KVACEGVNNDP 417
F + L+++ EEE+R +Q++ + L E ++ ++ + K E +
Sbjct: 1322 FISETLRRM--EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1379
Query: 418 DESMSSRISDTERSQKDAQ----TVEEESLTLSREDAEQV---ALEVDLNQKKRRRKKQD 470
+ M + E + DAQ +++EE L + ++ A + + ++ R R ++
Sbjct: 1380 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE- 1438
Query: 471 GANELGVNNL-LENATVQAGPSKGEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGIVG 529
E+ V L LE Q G ++GE QA+R +E E K Q + + V
Sbjct: 1439 ---EIRVVRLQLEATERQRGGAEGE-----LQALRARAEEAEAQKRQAQEEAERLRRQVQ 1490
Query: 530 FASTEKVEKRTDPILSLSNQQDATSVATESSESSTSDLPSFEVGIRALCEVNNAEGSCIE 589
S K + + L+++ A + A + + ++AL E+ ++
Sbjct: 1491 DESQRKRQAEVE----LASRVKAEAEAAREKQRA----------LQALEELR------LQ 1530
Query: 590 ERNVDLKNNSLEIDQTENVKPMLRGRFQRPKPNLSRAGKKSVLSQGKTESESKNSHSKTS 649
+ + E+++ V+ L ++ ++ L + K + + S
Sbjct: 1531 AEEAERRLRQAEVERARQVQVALE---------TAQRSAEAELQSKRASFAEKTAQLERS 1581
Query: 650 VEKNHVEKDKMNTLDILRMETTERENPEAETVSVLGEKNCLQEGSQLKALRPVQVR---- 705
+++ HV + LR E R +AE E E QLKA +++R
Sbjct: 1582 LQEEHVAVAQ------LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1635
Query: 706 ----------GRLQKPKPNAGKAAERK----EILISQEEIGANVEKNENESCADRDTPQH 751
+K K A + A R+ E + Q E+ A E + A+ Q
Sbjct: 1636 EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL-AEQELEKQRQLAEGTAQQR 1694
Query: 752 ME---------------DQSRKDFEEEDVILQPEKNDSFQNVQPDEPKVLNECLSVQENN 796
+ +Q R+ EEE LQ E + Q Q E + L + + E
Sbjct: 1695 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE-LAKVRAEMEVL 1753
Query: 797 KANKLNQVPILRTRFQKPKPNIGRGTGR-REISSKEEVLEKIL----------------- 838
A+K R+ +K K + GR RE++ + L +
Sbjct: 1754 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ 1813
Query: 839 ------VSGEMAAALRETVRLDTSPKEMVPAEINTKEMQSDLKETGR----RAISPREKI 888
V E AA+ E RL T AEI KE +++ + R A R
Sbjct: 1814 RAEAERVLAEKLAAIGEATRLKTE------AEIALKEKEAENERLRRLAEDEAFQRRRLE 1867
Query: 889 LDVIDDTIEMETGL----KAMGREICLREKTPEVIDATEEIDKDLEE------------- 931
++E L KA E+ E+ +++ T + +EE
Sbjct: 1868 EQAAQHKADIEERLAQLRKASDSEL---ERQKGLVEDTLRQRRQVEEEILALKASFEKAA 1924
Query: 932 AGRREISPQ-----KNGPEEVKPLGEVETDLKATGNESSPREKTPEVTDATEEIDKNL-- 984
AG+ E+ + N + ++ + + +L+A E+ +A E + K+L
Sbjct: 1925 AGKAELELELGRIRSNAEDTLR--SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 1982
Query: 985 -EETGRRKISPRENGPEEVKPVDEMETDLNATGRESSPREKTPEVIDATEEIDLEETERE 1043
EE R++ + E E +K E L + S R+ A + + EE
Sbjct: 1983 EEEAARQRKAALEE-VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA 2041
Query: 1044 VSPQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEVIDAIEEIEIDLEETEREISPQEN 1103
+ Q+ E + L + ++ L RG+ A EE E + ERE +
Sbjct: 2042 FAVQQKEQELQQTLQQEQSVLDQL------RGEAEAARRAAEEAEEARVQAEREAAQSRR 2095
Query: 1104 GLEEVKPL---GEMQTDLKATGREISPREKTPEVIDATEEIDKDLEETGRREISPEENGP 1160
+EE + L E Q +A + A E++ K+ E+ R E+
Sbjct: 2096 QVEEAERLKQSAEEQAQARAQAQA------------AAEKLRKEAEQEAARRAQAEQAAL 2143
Query: 1161 EEVKPVD-EMETDLKTTGREGSSREKTREVIDAAEVIETDLEETEREISPQENGPEEVKP 1219
+ + D EME K E + R+K +V + LEET+ + + + + +K
Sbjct: 2144 RQKQAADAEMEKHKKFA--EQTLRQKA-QVEQELTTLRLQLEETDHQKNLLDEELQRLKA 2200
Query: 1220 VGKMETDLKEIREEISQREKVLAEFSAIREKEIDLK------ETGKRDIPIMEKVSGKMA 1273
E E QR +V E ++R + +L E R + + +K + +
Sbjct: 2201 ---------EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF 2251
Query: 1274 VVEEMEADLKETGKENFRERGSEEICVTEEKVAELKQTGKTDISPR----ENELEETSTS 1329
+ EE E +K+ +E R + V ++ A L+Q + D++ + E L+E +
Sbjct: 2252 LQEEAEK-MKQVAEEAAR------LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA 2304
Query: 1330 RQTDTHLMQSGSNDFSAVPSLDIQNISSEVLSMMHTPVEEKRNSEKEVSSHFSHFKISSQ 1389
Q T L +E+L +E+ +E +++ Q
Sbjct: 2305 VQEATRL-----------------KAEAELLQQQKELAQEQARRLQEDKE-----QMAQQ 2342
Query: 1390 THESDKTEVQGIQSPDVPEQFSDINLSKSLPQEQKPLEIKPAPFVRSRFKRPKPNLARAA 1449
E E QG Q E+ + +S E + L+++ A R++ R + + R
Sbjct: 2343 LAE----ETQGFQRTLEAERQRQLEMSA----EAERLKLRVAEMSRAQ-ARAEEDAQR-- 2391
Query: 1450 LKRETTESEKYIYEKKSETKKMETIV--MQENNEQTDTLPSQHDEASLMISREKDTLGHR 1507
+++ E + ++ + T++ T+V ++ +Q+D + EA + REK+ L
Sbjct: 2392 FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL--- 2448
Query: 1508 NEEAVILPCTQTE-RNLSPSNSCEPKEESQSAPVQKNDSVVSVGT--NNVNTFQQEMKES 1564
+EA +L E + + + + Q + + + DS++ +++ +
Sbjct: 2449 QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2508
Query: 1565 VIQTARQVRGRLQRPRPNIRKTGQRQIVDKGEAK--------GIIKEGRTILPKDE---T 1613
+ A+Q+R QR + + + QR + EA+ G+ ++ + ++
Sbjct: 2509 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2568
Query: 1614 EKKVLTVSNSQIETEIEVPSSAVPEHRMYENQSQVVLVENLHVNKTNETIRH-------E 1666
++++L N ++ ++++ +HR S+ V + KT R E
Sbjct: 2569 QEELLAEENQRLREQLQLLEE---QHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAE 2625
Query: 1667 NKPYVPSSAQMTRRKFQKAKPNLGRAHSKKEEPVLEKVTTDQSKEGKPED--HLLQKGAS 1724
+P S RRK + S +E L + T + + ED H LQ +S
Sbjct: 2626 AEP--EHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSS 2683
Query: 1725 NTQLLLKEKAELLT 1738
LLLK E L+
Sbjct: 2684 IAGLLLKATNEKLS 2697
Score = 68.9 bits (167), Expect = 6e-11
Identities = 233/1260 (18%), Positives = 491/1260 (38%), Gaps = 203/1260 (16%)
Query: 326 GQLFPHRARIEIKNKFKREEKTNGWRIDKAFQEKRPFDFDFFAHLLQKVLAEEEKRKQKS 385
G+L RAR E KR+ + R+ + Q++ L +V AE E ++K
Sbjct: 1459 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1518
Query: 386 VKNHSLKE-----KKSTKPRKNVKVKK-----VACEGVNNDPD-ESMSSRISDTERSQKD 434
+L+E +++ + + +V++ VA E + E S R S E++ +
Sbjct: 1519 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1578
Query: 435 AQTVEEESLTLS--REDAEQVALEVDLNQKKRRRKKQDGANELGVNNLLENATVQAGPSK 492
++++EE + ++ RE+AE+ A + Q + R +++ EL L N
Sbjct: 1579 ERSLQEEHVAVAQLREEAERRAQQ----QAEAERAREEAERELERWQLKAN--------- 1625
Query: 493 GEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGIVGFASTEKVEKRTDPILSLSNQQDA 552
+A+R L+ E ++++ L A E +++ + + A
Sbjct: 1626 --------EALRLRLQAEEVAQQKSL------------AQAEAEKQKEEAEREARRRGKA 1665
Query: 553 TSVATESSESSTSDLPSFEVGIRALCEVNNAEGSCIEERNVDLKNNSLEIDQTENVKPML 612
A E + +L R L E + E+ + L+ E +Q E + +L
Sbjct: 1666 EEQAVRQRELAEQELEK----QRQLAEGTAQQRLAAEQELIRLR---AETEQGEQQRQLL 1718
Query: 613 RGRFQRPKPNLSRAGKKSVLSQGKTESESKNSHSKTSV---EKNHVEKDKMNTLDILRME 669
R L R + + + E+E ++ V K E++ +T + +
Sbjct: 1719 EEELAR----LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE----K 1770
Query: 670 TTERENPEAETVSVLGEKNCLQEGSQLKALRPVQVRGRLQKPKPNAGKAAERKEILI--- 726
+ +R EA L E E ++L+AL R R + A + AE + +L
Sbjct: 1771 SKQRLEAEAGRFRELAE-----EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1825
Query: 727 ----------SQEEIGANVEKNENE--------SCADRDTPQHMEDQSRKDFEEEDVILQ 768
++ EI ++ ENE R + Q + D EE L+
Sbjct: 1826 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1885
Query: 769 PEKNDSFQNVQPDEPKVLNECLSVQENNKANKLNQVPILRTRFQKPKPNIGRGTGRREIS 828
+ + + L + V+E ++ L+ F+K G+ E+
Sbjct: 1886 KASDSELERQKGLVEDTLRQRRQVEE--------EILALKASFEK------AAAGKAEL- 1930
Query: 829 SKEEVLEKILVSGEMAAALRETVRLDTSPKEMVPAEINTKEMQSDLKETGRRAISPREKI 888
E L +I + E +E L+ + + + AE + +++ E +++++ E+
Sbjct: 1931 --ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE--ERVQKSLAAEEEA 1986
Query: 889 LDVIDDTIEMETGLKAMG------REICLREKTPEVIDATEEIDKDLEEAGRREISPQKN 942
+E LKA RE +E ++ A E K L+ + +
Sbjct: 1987 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2046
Query: 943 GPEEVKPLGEVETDL--KATGNESSPREKTPEVTDATEEID-------KNLEETGRRKIS 993
+E++ + E + + G + R E +A + + + +EE R K S
Sbjct: 2047 KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQS 2106
Query: 994 PREN---------GPEEVKPVDEMETDLNATGRESSPREKTPEVIDATEEID---LEETE 1041
E E+++ E E A +++ R+K + DA E E+T
Sbjct: 2107 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK--QAADAEMEKHKKFAEQTL 2164
Query: 1042 REVSPQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEVIDAIEEIEIDLEETEREISPQ 1101
R+ + E L ++ L ETD + D + ++ ++ + E R+ S
Sbjct: 2165 RQKAQVEQELTTLR-LQLEETDHQKNLLD-----------EELQRLKAEATEAARQRSQV 2212
Query: 1102 ENGLEEVK----PLGEMQTDLKATGREISPREKTPE---VIDATEEIDKDLEETGRREIS 1154
E L V+ L +++ ++A R + R+K + + E++ + EE R ++
Sbjct: 2213 EEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2272
Query: 1155 PEENGPEEVKPVDEMETDLKTTGREGSSREKTREVIDAAEV-IETDLEETEREISPQENG 1213
+E ++ + E + + E +EK + V +A + E +L + ++E++ ++
Sbjct: 2273 AQE--AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ-- 2328
Query: 1214 PEEVKPVGKMETDLKEIREEISQREKVLAE-FSAIREKEIDLKETGKRDIPIMEKVSGKM 1272
+++ D +++ +++++ + A R++++++ +R + ++S
Sbjct: 2329 ------ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2382
Query: 1273 AVVEE----MEADLKETGKENFRERGSEEICVTEEKVAELKQTGKTDISPREN----ELE 1324
A EE +E G++ R + + VT + E+++ + R ELE
Sbjct: 2383 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2442
Query: 1325 ETSTSRQTDTHLMQSGSNDFSAVPSLDIQNISSEVLSMMHTPVEEKRNSEKEVSSHFSHF 1384
Q + L+Q + S ++Q + E L +++ SEK+ F
Sbjct: 2443 REKEKLQQEAKLLQ--------LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2494
Query: 1385 KISSQTHESDKTEVQGIQSPDVPEQFSDINLSKSLPQEQKPLEIKPAPFVRSRFK-RPKP 1443
E +K +++ + +V + L + ++Q+ +E + V S + R +
Sbjct: 2495 ------IEQEKAKLEQLFQDEVAKA---QQLREEQQRQQQQMEQERQRLVASMEEARRRQ 2545
Query: 1444 NLARAALKRETTESEKYIYEKKSETKKMETIVMQEN---NEQTDTLPSQHDEASLMISRE 1500
+ A ++R+ E + + + + ++ E ++ +EN EQ L QH A+L S E
Sbjct: 2546 HEAEEGVRRKQEE----LQQLEQQRRQQEELLAEENQRLREQLQLLEEQH-RAALAHSEE 2600
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 75.1 bits (183), Expect = 9e-13
Identities = 297/1514 (19%), Positives = 566/1514 (37%), Gaps = 279/1514 (18%)
Query: 366 FFAHLLQKVLAEEEKR---KQKSVKNHSLKEKKSTKPRKNVKVK-----KVACEGVNNDP 417
F + L+++ EEE+R +Q++ + L E ++ ++ + K E +
Sbjct: 1363 FISETLRRM--EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1420
Query: 418 DESMSSRISDTERSQKDAQ----TVEEESLTLSREDAEQV---ALEVDLNQKKRRRKKQD 470
+ M + E + DAQ +++EE L + ++ A + + ++ R R ++
Sbjct: 1421 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE- 1479
Query: 471 GANELGVNNL-LENATVQAGPSKGEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGIVG 529
E+ V L LE Q G ++GE QA+R +E E K Q + + V
Sbjct: 1480 ---EIRVVRLQLEATERQRGGAEGE-----LQALRARAEEAEAQKRQAQEEAERLRRQVQ 1531
Query: 530 FASTEKVEKRTDPILSLSNQQDATSVATESSESSTSDLPSFEVGIRALCEVNNAEGSCIE 589
S K + + L+++ A + A + + ++AL E+ ++
Sbjct: 1532 DESQRKRQAEVE----LASRVKAEAEAAREKQRA----------LQALEELR------LQ 1571
Query: 590 ERNVDLKNNSLEIDQTENVKPMLRGRFQRPKPNLSRAGKKSVLSQGKTESESKNSHSKTS 649
+ + E+++ V+ L ++ ++ L + K + + S
Sbjct: 1572 AEEAERRLRQAEVERARQVQVALE---------TAQRSAEAELQSKRASFAEKTAQLERS 1622
Query: 650 VEKNHVEKDKMNTLDILRMETTERENPEAETVSVLGEKNCLQEGSQLKALRPVQVR---- 705
+++ HV + LR E R +AE E E QLKA +++R
Sbjct: 1623 LQEEHVAVAQ------LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1676
Query: 706 ----------GRLQKPKPNAGKAAERK----EILISQEEIGANVEKNENESCADRDTPQH 751
+K K A + A R+ E + Q E+ A E + A+ Q
Sbjct: 1677 EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL-AEQELEKQRQLAEGTAQQR 1735
Query: 752 ME---------------DQSRKDFEEEDVILQPEKNDSFQNVQPDEPKVLNECLSVQENN 796
+ +Q R+ EEE LQ E + Q Q E + L + + E
Sbjct: 1736 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE-LAKVRAEMEVL 1794
Query: 797 KANKLNQVPILRTRFQKPKPNIGRGTGR-REISSKEEVLEKIL----------------- 838
A+K R+ +K K + GR RE++ + L +
Sbjct: 1795 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ 1854
Query: 839 ------VSGEMAAALRETVRLDTSPKEMVPAEINTKEMQSDLKETGR----RAISPREKI 888
V E AA+ E RL T AEI KE +++ + R A R
Sbjct: 1855 RAEAERVLAEKLAAIGEATRLKTE------AEIALKEKEAENERLRRLAEDEAFQRRRLE 1908
Query: 889 LDVIDDTIEMETGL----KAMGREICLREKTPEVIDATEEIDKDLEE------------- 931
++E L KA E+ E+ +++ T + +EE
Sbjct: 1909 EQAAQHKADIEERLAQLRKASDSEL---ERQKGLVEDTLRQRRQVEEEILALKASFEKAA 1965
Query: 932 AGRREISPQ-----KNGPEEVKPLGEVETDLKATGNESSPREKTPEVTDATEEIDKNL-- 984
AG+ E+ + N + ++ + + +L+A E+ +A E + K+L
Sbjct: 1966 AGKAELELELGRIRSNAEDTLR--SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 2023
Query: 985 -EETGRRKISPRENGPEEVKPVDEMETDLNATGRESSPREKTPEVIDATEEIDLEETERE 1043
EE R++ + E E +K E L + S R+ A + + EE
Sbjct: 2024 EEEAARQRKAALEE-VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA 2082
Query: 1044 VSPQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEVIDAIEEIEIDLEETEREISPQEN 1103
+ Q+ E + L + ++ L RG+ A EE E + ERE +
Sbjct: 2083 FAVQQKEQELQQTLQQEQSVLDQL------RGEAEAARRAAEEAEEARVQAEREAAQSRR 2136
Query: 1104 GLEEVKPL---GEMQTDLKATGREISPREKTPEVIDATEEIDKDLEETGRREISPEENGP 1160
+EE + L E Q +A + A E++ K+ E+ R E+
Sbjct: 2137 QVEEAERLKQSAEEQAQARAQAQA------------AAEKLRKEAEQEAARRAQAEQAAL 2184
Query: 1161 EEVKPVD-EMETDLKTTGREGSSREKTREVIDAAEVIETDLEETEREISPQENGPEEVKP 1219
+ + D EME K E + R+K +V + LEET+ + + + + +K
Sbjct: 2185 RQKQAADAEMEKHKKFA--EQTLRQKA-QVEQELTTLRLQLEETDHQKNLLDEELQRLKA 2241
Query: 1220 VGKMETDLKEIREEISQREKVLAEFSAIREKEIDLK------ETGKRDIPIMEKVSGKMA 1273
E E QR +V E ++R + +L E R + + +K + +
Sbjct: 2242 ---------EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF 2292
Query: 1274 VVEEMEADLKETGKENFRERGSEEICVTEEKVAELKQTGKTDISPR----ENELEETSTS 1329
+ EE E +K+ +E R + V ++ A L+Q + D++ + E L+E +
Sbjct: 2293 LQEEAEK-MKQVAEEAAR------LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA 2345
Query: 1330 RQTDTHLMQSGSNDFSAVPSLDIQNISSEVLSMMHTPVEEKRNSEKEVSSHFSHFKISSQ 1389
Q T L +E+L +E+ +E +++ Q
Sbjct: 2346 VQEATRL-----------------KAEAELLQQQKELAQEQARRLQEDKE-----QMAQQ 2383
Query: 1390 THESDKTEVQGIQSPDVPEQFSDINLSKSLPQEQKPLEIKPAPFVRSRFKRPKPNLARAA 1449
E E QG Q E+ + +S E + L+++ A R++ R + + R
Sbjct: 2384 LAE----ETQGFQRTLEAERQRQLEMSA----EAERLKLRVAEMSRAQ-ARAEEDAQR-- 2432
Query: 1450 LKRETTESEKYIYEKKSETKKMETIV--MQENNEQTDTLPSQHDEASLMISREKDTLGHR 1507
+++ E + ++ + T++ T+V ++ +Q+D + EA + REK+ L
Sbjct: 2433 FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL--- 2489
Query: 1508 NEEAVILPCTQTE-RNLSPSNSCEPKEESQSAPVQKNDSVVSVGT--NNVNTFQQEMKES 1564
+EA +L E + + + + Q + + + DS++ +++ +
Sbjct: 2490 QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2549
Query: 1565 VIQTARQVRGRLQRPRPNIRKTGQRQIVDKGEAK--------GIIKEGRTILPKDE---T 1613
+ A+Q+R QR + + + QR + EA+ G+ ++ + ++
Sbjct: 2550 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2609
Query: 1614 EKKVLTVSNSQIETEIEVPSSAVPEHRMYENQSQVVLVENLHVNKTNETIRH-------E 1666
++++L N ++ ++++ +HR S+ V + KT R E
Sbjct: 2610 QEELLAEENQRLREQLQLLEE---QHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAE 2666
Query: 1667 NKPYVPSSAQMTRRKFQKAKPNLGRAHSKKEEPVLEKVTTDQSKEGKPED--HLLQKGAS 1724
+P S RRK + S +E L + T + + ED H LQ +S
Sbjct: 2667 AEP--EHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSS 2724
Query: 1725 NTQLLLKEKAELLT 1738
LLLK E L+
Sbjct: 2725 IAGLLLKATNEKLS 2738
Score = 68.9 bits (167), Expect = 6e-11
Identities = 233/1260 (18%), Positives = 491/1260 (38%), Gaps = 203/1260 (16%)
Query: 326 GQLFPHRARIEIKNKFKREEKTNGWRIDKAFQEKRPFDFDFFAHLLQKVLAEEEKRKQKS 385
G+L RAR E KR+ + R+ + Q++ L +V AE E ++K
Sbjct: 1500 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1559
Query: 386 VKNHSLKE-----KKSTKPRKNVKVKK-----VACEGVNNDPD-ESMSSRISDTERSQKD 434
+L+E +++ + + +V++ VA E + E S R S E++ +
Sbjct: 1560 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1619
Query: 435 AQTVEEESLTLS--REDAEQVALEVDLNQKKRRRKKQDGANELGVNNLLENATVQAGPSK 492
++++EE + ++ RE+AE+ A + Q + R +++ EL L N
Sbjct: 1620 ERSLQEEHVAVAQLREEAERRAQQ----QAEAERAREEAERELERWQLKAN--------- 1666
Query: 493 GEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGIVGFASTEKVEKRTDPILSLSNQQDA 552
+A+R L+ E ++++ L A E +++ + + A
Sbjct: 1667 --------EALRLRLQAEEVAQQKSL------------AQAEAEKQKEEAEREARRRGKA 1706
Query: 553 TSVATESSESSTSDLPSFEVGIRALCEVNNAEGSCIEERNVDLKNNSLEIDQTENVKPML 612
A E + +L R L E + E+ + L+ E +Q E + +L
Sbjct: 1707 EEQAVRQRELAEQELEK----QRQLAEGTAQQRLAAEQELIRLR---AETEQGEQQRQLL 1759
Query: 613 RGRFQRPKPNLSRAGKKSVLSQGKTESESKNSHSKTSV---EKNHVEKDKMNTLDILRME 669
R L R + + + E+E ++ V K E++ +T + +
Sbjct: 1760 EEELAR----LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE----K 1811
Query: 670 TTERENPEAETVSVLGEKNCLQEGSQLKALRPVQVRGRLQKPKPNAGKAAERKEILI--- 726
+ +R EA L E E ++L+AL R R + A + AE + +L
Sbjct: 1812 SKQRLEAEAGRFRELAE-----EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1866
Query: 727 ----------SQEEIGANVEKNENE--------SCADRDTPQHMEDQSRKDFEEEDVILQ 768
++ EI ++ ENE R + Q + D EE L+
Sbjct: 1867 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1926
Query: 769 PEKNDSFQNVQPDEPKVLNECLSVQENNKANKLNQVPILRTRFQKPKPNIGRGTGRREIS 828
+ + + L + V+E ++ L+ F+K G+ E+
Sbjct: 1927 KASDSELERQKGLVEDTLRQRRQVEE--------EILALKASFEK------AAAGKAEL- 1971
Query: 829 SKEEVLEKILVSGEMAAALRETVRLDTSPKEMVPAEINTKEMQSDLKETGRRAISPREKI 888
E L +I + E +E L+ + + + AE + +++ E +++++ E+
Sbjct: 1972 --ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE--ERVQKSLAAEEEA 2027
Query: 889 LDVIDDTIEMETGLKAMG------REICLREKTPEVIDATEEIDKDLEEAGRREISPQKN 942
+E LKA RE +E ++ A E K L+ + +
Sbjct: 2028 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2087
Query: 943 GPEEVKPLGEVETDL--KATGNESSPREKTPEVTDATEEID-------KNLEETGRRKIS 993
+E++ + E + + G + R E +A + + + +EE R K S
Sbjct: 2088 KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQS 2147
Query: 994 PREN---------GPEEVKPVDEMETDLNATGRESSPREKTPEVIDATEEID---LEETE 1041
E E+++ E E A +++ R+K + DA E E+T
Sbjct: 2148 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK--QAADAEMEKHKKFAEQTL 2205
Query: 1042 REVSPQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEVIDAIEEIEIDLEETEREISPQ 1101
R+ + E L ++ L ETD + D + ++ ++ + E R+ S
Sbjct: 2206 RQKAQVEQELTTLR-LQLEETDHQKNLLD-----------EELQRLKAEATEAARQRSQV 2253
Query: 1102 ENGLEEVK----PLGEMQTDLKATGREISPREKTPE---VIDATEEIDKDLEETGRREIS 1154
E L V+ L +++ ++A R + R+K + + E++ + EE R ++
Sbjct: 2254 EEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2313
Query: 1155 PEENGPEEVKPVDEMETDLKTTGREGSSREKTREVIDAAEV-IETDLEETEREISPQENG 1213
+E ++ + E + + E +EK + V +A + E +L + ++E++ ++
Sbjct: 2314 AQE--AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ-- 2369
Query: 1214 PEEVKPVGKMETDLKEIREEISQREKVLAE-FSAIREKEIDLKETGKRDIPIMEKVSGKM 1272
+++ D +++ +++++ + A R++++++ +R + ++S
Sbjct: 2370 ------ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2423
Query: 1273 AVVEE----MEADLKETGKENFRERGSEEICVTEEKVAELKQTGKTDISPREN----ELE 1324
A EE +E G++ R + + VT + E+++ + R ELE
Sbjct: 2424 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2483
Query: 1325 ETSTSRQTDTHLMQSGSNDFSAVPSLDIQNISSEVLSMMHTPVEEKRNSEKEVSSHFSHF 1384
Q + L+Q + S ++Q + E L +++ SEK+ F
Sbjct: 2484 REKEKLQQEAKLLQ--------LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2535
Query: 1385 KISSQTHESDKTEVQGIQSPDVPEQFSDINLSKSLPQEQKPLEIKPAPFVRSRFK-RPKP 1443
E +K +++ + +V + L + ++Q+ +E + V S + R +
Sbjct: 2536 ------IEQEKAKLEQLFQDEVAKA---QQLREEQQRQQQQMEQERQRLVASMEEARRRQ 2586
Query: 1444 NLARAALKRETTESEKYIYEKKSETKKMETIVMQEN---NEQTDTLPSQHDEASLMISRE 1500
+ A ++R+ E + + + + ++ E ++ +EN EQ L QH A+L S E
Sbjct: 2587 HEAEEGVRRKQEE----LQQLEQQRRQQEELLAEENQRLREQLQLLEEQH-RAALAHSEE 2641
>gi|118498356 kinectin 1 isoform a [Homo sapiens]
Length = 1357
Score = 74.3 bits (181), Expect = 1e-12
Identities = 264/1413 (18%), Positives = 545/1413 (38%), Gaps = 204/1413 (14%)
Query: 364 FDFFAHLLQKVLAEE----EKRKQKSVKNHSLKEKKSTKPRKNVKVKKVACEGVNNDPDE 419
F FF +++ L +E +KR+QK + + K+K K K +++ N + E
Sbjct: 22 FLFFWLFMKETLYDEVLAKQKREQKLIPTKTDKKKAEKKKNKKKEIQ-------NGNLHE 74
Query: 420 SMSSRISDTERSQKDAQTVEEESLTLSREDAEQVALEVDLNQKKRRRKKQDGANELGVNN 479
S S + + DA VE++ ++ V + ++K++ KKQ E
Sbjct: 75 SDSESV-PRDFKLSDALAVEDDQ--VAPVPLNVVETSSSVRERKKKEKKQKPVLE---EQ 128
Query: 480 LLENATVQAGPSKGEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGIVGFASTEKVEKR 539
+++ + P K + + P + K+ ++N ++ +K+
Sbjct: 129 VIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKN--------GSDDQDKK 180
Query: 540 TDPILSLSNQQDATSVATESSESSTSDLPSFEVGIRALCEVNNAEGSCIEERNVDLKNNS 599
+ ++ S +Q+A + E+ + S S +A + E ++E +
Sbjct: 181 VETLMVPSKRQEALPLHQETKQESGSGKK------KASSKKQKTENVFVDEPLIHATTYI 234
Query: 600 LEIDQTENVKPMLRGR--FQRPKPNLSRAGKKSVLSQGKTESESKNSHSK-----TSVEK 652
+D ++ P++ R KP+ +KS + KTE++ +N+ K S++
Sbjct: 235 PLMDNADS-SPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKT 293
Query: 653 NHVEKDK-MNTLDILR-----METTERENPEAETVSVLGEKNCLQEGSQLKAL------- 699
+D+ + +D+L+ ++ +++ + E +++ + LQE +L A
Sbjct: 294 MMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQ---LQEKDKLLAAVKEDAAA 350
Query: 700 ---RPVQVRGRLQKPKPNAGKAAERKEILISQEEIGANVEKNE-NESCADRDTPQHMEDQ 755
R Q+ + K + R + I E NV +N+ + S + Q Q
Sbjct: 351 TKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQ 410
Query: 756 SRKDFE-------EEDVILQPEKNDSFQNVQPDEPKVLNEC------LSVQENNKANKLN 802
R+ E +E+ IL+ +++ ++ + LN+ L + K KL
Sbjct: 411 VREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQ 470
Query: 803 QVPILRTRFQKPKPNIGRGTGRREISSKEEVLEKILVSGEMAAALRETVRLDTSPKEMVP 862
Q + + ++ + + ++ E E++ A E + D K V
Sbjct: 471 QEEVQKKNAEQAATQL-----KVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSK-FVA 524
Query: 863 AEINTKEMQSDLKETGRRAISPREKILDVIDDTIEMETGLKAMGREICLREKTPEVIDAT 922
E + + S L +T ++++ + ME+ K + +E L+ + ++++
Sbjct: 525 KENEVQSLHSKLTDTLVSKQQLEQRLMQL------MESEQKRVNKEESLQMQVQDILEQN 578
Query: 923 EEIDKDLEEAGRREISPQKNGPEEVKPLGEV--ETDLKATGNESSPREKTPEVTDATEEI 980
E + +++ +I+ Q + + L +V E D + E S + +T EE+
Sbjct: 579 EALKAQIQQF-HSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEEL 637
Query: 981 DKNLEETGRRKISPRENGPEEVKPVDEMETDLNATGRESSPREKTPEVIDATEEIDLEET 1040
K+++ EV+ + + + A E +++ V D + E+
Sbjct: 638 -KDIQNMNFLL-------KAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQL 689
Query: 1041 EREVSPQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEVIDAIEEIEIDLEETEREISP 1100
+ E+S N +EE K L + LK+ + D +E++E ++E + ++
Sbjct: 690 QHEIS---NKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKT 746
Query: 1101 QENGLEE-VKPLGEMQTDLKATGREISPREKTPEVIDATEEID---KDLEETGRREISPE 1156
E LE + + + +L A E S K + + A + L E ++ I +
Sbjct: 747 VEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEK 806
Query: 1157 ENGPEEVKPVDEMETDLKTTGREGSSREKTREVIDAAEVIETDLEETEREISPQENGPEE 1216
+ + V+ + E E LK +E + ++ +E+ E I E +++S
Sbjct: 807 DGKIKSVEELLEAEL-LKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLS-------I 858
Query: 1217 VKPVGKMETDLKEIREEISQREKVLAEFSAIREKEIDLKETGKRDIPIMEKVSGKMAVVE 1276
V +++ LK E+++ + VL EKE DL TGK + E+ E
Sbjct: 859 TSKVQELQNLLKGKEEQMNTMKAVL------EEKEKDLANTGKWLQDLQEE-------NE 905
Query: 1277 EMEADLKETGKENFRERGS----EEI-CVTEEKVAELK------QTGKTDISPRENELEE 1325
++A ++E + N +E S EE+ V +EK ELK + ++D+S + L++
Sbjct: 906 SLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQD 965
Query: 1326 TSTSR-----QTDTHLMQSGSNDFSAVPSLDIQNISSE----------VLSMMHTPVEEK 1370
Q + Q+ S P ++ + SE L + VE +
Sbjct: 966 VQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQ 1025
Query: 1371 RNSEKEV-SSHFSHFKISSQTHES-----DKTEVQGIQSPDVPEQFSDINLSKSLPQEQK 1424
R ++ ++ + + T + +KT + Q + E + L K P+
Sbjct: 1026 RKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSV 1085
Query: 1425 PLEIKPAPFVRSRFKRPKPNLARAALKRET------------------TESEKY---IYE 1463
P + ++ K+ K +A + E E EKY + E
Sbjct: 1086 PSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAE 1145
Query: 1464 KKSETKKMETIVMQENN--------------EQTDTLPSQHDEASLMISREKDTLGHRNE 1509
+ +K++ V QE N + + S E + S KD R E
Sbjct: 1146 TEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRRE 1205
Query: 1510 EAVI---LPCTQTERNLSPSNSCEPKEESQSAPVQKNDSVVSVGTNN--VNTFQQEMKES 1564
+ L + ER+ + E K+ + +DS N +N + ++ E+
Sbjct: 1206 REHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNET 1265
Query: 1565 VI-----QTARQ-VRGRLQRPRPNIRKTGQRQIVDKGEAKGIIKEGRTILPKDE-TEKKV 1617
+ Q RQ V G L + + ++ + + G+ I E + P+ E +EK+
Sbjct: 1266 LTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVI--ENSDVSPETESSEKET 1323
Query: 1618 LTVSNSQIETEIEVPSSAVPEHRMYENQSQVVL 1650
++VS +Q T+++ AV + E + VL
Sbjct: 1324 MSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVL 1356
Score = 42.4 bits (98), Expect = 0.006
Identities = 179/962 (18%), Positives = 372/962 (38%), Gaps = 123/962 (12%)
Query: 1092 EETEREIS--PQENG-LEEVKPLGEMQTDLKATGREISPREKTPEVIDATEEIDKDLEET 1148
E+ E EI+ QENG L + Q + K + R+ D +++ E+T
Sbjct: 413 EQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQ------DYARLVNELTEKT 466
Query: 1149 GRREISPEENGPEEV--KPVDEMETDLKTTGREGSSR--EKTREVIDAAEVIETDLEETE 1204
G+ + EEV K ++ T LK +E R E + E ++ +
Sbjct: 467 GKLQ-------QEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQ 519
Query: 1205 REISPQENGPEEVKPVGKMETDLKEIREEISQREKVLAEFSAIREKEIDLKETGKRDIP- 1263
+ +EN EV+ + TD ++++ QR L + +K ++ +E+ + +
Sbjct: 520 SKFVAKEN---EVQSLHSKLTDTLVSKQQLEQR---LMQLMESEQKRVNKEESLQMQVQD 573
Query: 1264 IMEKVSGKMAVVEEMEADLKETGKENFRERGSEEICVTEEKVAELKQTGKTDISPREN-- 1321
I+E+ A +++ + + + + E V EK ++KQT + S R+
Sbjct: 574 ILEQNEALKAQIQQFHSQI--AAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLT 631
Query: 1322 ELEETSTSRQTDTHLMQSGSNDFSAVPSLDIQNISSEVLSMMHTPVEEKRNS-------- 1373
EE Q L+++ A+ + Q ++ L M V K +
Sbjct: 632 SKEEELKDIQNMNFLLKAEVQKLQALANE--QAAAAHELEKMQQSVYVKDDKIRLLEEQL 689
Query: 1374 EKEVSSHFSHFKISSQTHESDKTEVQGIQSPDVPEQFSDI--NLSKSLPQEQKPL----E 1427
+ E+S+ FKI + +++ K+EVQ +Q+ + D+ + K + ++ + L E
Sbjct: 690 QHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEE 749
Query: 1428 IKPAPFVRSRFKRPKPNLARAALKRETTESEKYIYEKKSETKKMETIVMQENNEQTDTLP 1487
+ ++ K + N A++ E + K + + K+ K+ + + E+ +
Sbjct: 750 LLETGLIQVATKEEELN----AIRTENSSLTKEVQDLKA--KQNDQVSFASLVEELKKVI 803
Query: 1488 SQHDEASLMISR--EKDTLGHRNEEAVILPCTQTERNLSPSNSCEPKEESQ----SAPVQ 1541
+ D + E + L N+E + Q + L E++Q ++ VQ
Sbjct: 804 HEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQ 863
Query: 1542 KNDSVVSVGTNNVNTFQQEMKESVIQTA------RQVRGRLQRPRPNIRKTGQRQIVDKG 1595
+ +++ +NT + ++E A + ++ + + ++++ Q + +
Sbjct: 864 ELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEAS 923
Query: 1596 EAKGIIKEGRTILPKDETEKK----VLTVSNSQIETEIEVPSSAVPEHRMYENQSQVVLV 1651
A +E +L + E E K +L S + ++ ++ E++++ +SQ+ +
Sbjct: 924 SASQ-FEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLF--KSQIEQL 980
Query: 1652 ENLHVNKTNETIRHENKPYVPSSAQMTRRKFQKAKPNLGRA--HSKKE------------ 1697
+ + + + HE V S + +L A H +K+
Sbjct: 981 KQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAM 1040
Query: 1698 ------EPVLEKVTTDQSKEGKPEDHLLQKGASNTQLLLKEK---------AELLTSLEV 1742
E +L+ SKE + + ++ A L K E L E
Sbjct: 1041 EALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEK 1100
Query: 1743 SARKDCVGSKESALAKI-DAELEEVGPSRRVGEETVGDNSPSSVVEEQYLNKL-TSCPQP 1800
A++ G+ S K+ + +L+E + + E L KL S Q
Sbjct: 1101 KAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQE 1160
Query: 1801 LN------ETSYSKIALDGKTTISSTSEYERNRGERR---SHKKFKPNVTRGRGSKRVRG 1851
N + S+ I + SS E ER R E + + ++ + ++ +
Sbjct: 1161 ENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMER 1220
Query: 1852 KTSKKEPRASKAMLVTLRASQEEDDDADDFESDYEEESYHLAPEEVNKAPVFVPVGLRSP 1911
T E R K +L L Q++ DD+ E+ + E +L ++N+ +
Sbjct: 1221 STYVTEVRELKDLLTEL---QKKLDDSYS-EAVRQNEELNLLKAQLNETLTKLRTEQNER 1276
Query: 1912 EPVSAQIEETMEELEITVN--VPDVGCIAVVEHELPNTDVTTE-EMKQEENLSVPFEMTT 1968
+ V+ + + + LE+ + V G V+E N+DV+ E E ++E +SV T
Sbjct: 1277 QKVAGDLHKAQQSLELIQSKIVKAAGDTTVIE----NSDVSPETESSEKETMSVSLNQTV 1332
Query: 1969 SE 1970
++
Sbjct: 1333 TQ 1334
>gi|33620775 kinectin 1 isoform a [Homo sapiens]
Length = 1357
Score = 74.3 bits (181), Expect = 1e-12
Identities = 264/1413 (18%), Positives = 545/1413 (38%), Gaps = 204/1413 (14%)
Query: 364 FDFFAHLLQKVLAEE----EKRKQKSVKNHSLKEKKSTKPRKNVKVKKVACEGVNNDPDE 419
F FF +++ L +E +KR+QK + + K+K K K +++ N + E
Sbjct: 22 FLFFWLFMKETLYDEVLAKQKREQKLIPTKTDKKKAEKKKNKKKEIQ-------NGNLHE 74
Query: 420 SMSSRISDTERSQKDAQTVEEESLTLSREDAEQVALEVDLNQKKRRRKKQDGANELGVNN 479
S S + + DA VE++ ++ V + ++K++ KKQ E
Sbjct: 75 SDSESV-PRDFKLSDALAVEDDQ--VAPVPLNVVETSSSVRERKKKEKKQKPVLE---EQ 128
Query: 480 LLENATVQAGPSKGEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGIVGFASTEKVEKR 539
+++ + P K + + P + K+ ++N ++ +K+
Sbjct: 129 VIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKN--------GSDDQDKK 180
Query: 540 TDPILSLSNQQDATSVATESSESSTSDLPSFEVGIRALCEVNNAEGSCIEERNVDLKNNS 599
+ ++ S +Q+A + E+ + S S +A + E ++E +
Sbjct: 181 VETLMVPSKRQEALPLHQETKQESGSGKK------KASSKKQKTENVFVDEPLIHATTYI 234
Query: 600 LEIDQTENVKPMLRGR--FQRPKPNLSRAGKKSVLSQGKTESESKNSHSK-----TSVEK 652
+D ++ P++ R KP+ +KS + KTE++ +N+ K S++
Sbjct: 235 PLMDNADS-SPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKT 293
Query: 653 NHVEKDK-MNTLDILR-----METTERENPEAETVSVLGEKNCLQEGSQLKAL------- 699
+D+ + +D+L+ ++ +++ + E +++ + LQE +L A
Sbjct: 294 MMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQ---LQEKDKLLAAVKEDAAA 350
Query: 700 ---RPVQVRGRLQKPKPNAGKAAERKEILISQEEIGANVEKNE-NESCADRDTPQHMEDQ 755
R Q+ + K + R + I E NV +N+ + S + Q Q
Sbjct: 351 TKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQ 410
Query: 756 SRKDFE-------EEDVILQPEKNDSFQNVQPDEPKVLNEC------LSVQENNKANKLN 802
R+ E +E+ IL+ +++ ++ + LN+ L + K KL
Sbjct: 411 VREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQ 470
Query: 803 QVPILRTRFQKPKPNIGRGTGRREISSKEEVLEKILVSGEMAAALRETVRLDTSPKEMVP 862
Q + + ++ + + ++ E E++ A E + D K V
Sbjct: 471 QEEVQKKNAEQAATQL-----KVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSK-FVA 524
Query: 863 AEINTKEMQSDLKETGRRAISPREKILDVIDDTIEMETGLKAMGREICLREKTPEVIDAT 922
E + + S L +T ++++ + ME+ K + +E L+ + ++++
Sbjct: 525 KENEVQSLHSKLTDTLVSKQQLEQRLMQL------MESEQKRVNKEESLQMQVQDILEQN 578
Query: 923 EEIDKDLEEAGRREISPQKNGPEEVKPLGEV--ETDLKATGNESSPREKTPEVTDATEEI 980
E + +++ +I+ Q + + L +V E D + E S + +T EE+
Sbjct: 579 EALKAQIQQF-HSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEEL 637
Query: 981 DKNLEETGRRKISPRENGPEEVKPVDEMETDLNATGRESSPREKTPEVIDATEEIDLEET 1040
K+++ EV+ + + + A E +++ V D + E+
Sbjct: 638 -KDIQNMNFLL-------KAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQL 689
Query: 1041 EREVSPQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEVIDAIEEIEIDLEETEREISP 1100
+ E+S N +EE K L + LK+ + D +E++E ++E + ++
Sbjct: 690 QHEIS---NKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKT 746
Query: 1101 QENGLEE-VKPLGEMQTDLKATGREISPREKTPEVIDATEEID---KDLEETGRREISPE 1156
E LE + + + +L A E S K + + A + L E ++ I +
Sbjct: 747 VEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEK 806
Query: 1157 ENGPEEVKPVDEMETDLKTTGREGSSREKTREVIDAAEVIETDLEETEREISPQENGPEE 1216
+ + V+ + E E LK +E + ++ +E+ E I E +++S
Sbjct: 807 DGKIKSVEELLEAEL-LKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLS-------I 858
Query: 1217 VKPVGKMETDLKEIREEISQREKVLAEFSAIREKEIDLKETGKRDIPIMEKVSGKMAVVE 1276
V +++ LK E+++ + VL EKE DL TGK + E+ E
Sbjct: 859 TSKVQELQNLLKGKEEQMNTMKAVL------EEKEKDLANTGKWLQDLQEE-------NE 905
Query: 1277 EMEADLKETGKENFRERGS----EEI-CVTEEKVAELK------QTGKTDISPRENELEE 1325
++A ++E + N +E S EE+ V +EK ELK + ++D+S + L++
Sbjct: 906 SLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQD 965
Query: 1326 TSTSR-----QTDTHLMQSGSNDFSAVPSLDIQNISSE----------VLSMMHTPVEEK 1370
Q + Q+ S P ++ + SE L + VE +
Sbjct: 966 VQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQ 1025
Query: 1371 RNSEKEV-SSHFSHFKISSQTHES-----DKTEVQGIQSPDVPEQFSDINLSKSLPQEQK 1424
R ++ ++ + + T + +KT + Q + E + L K P+
Sbjct: 1026 RKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSV 1085
Query: 1425 PLEIKPAPFVRSRFKRPKPNLARAALKRET------------------TESEKY---IYE 1463
P + ++ K+ K +A + E E EKY + E
Sbjct: 1086 PSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAE 1145
Query: 1464 KKSETKKMETIVMQENN--------------EQTDTLPSQHDEASLMISREKDTLGHRNE 1509
+ +K++ V QE N + + S E + S KD R E
Sbjct: 1146 TEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRRE 1205
Query: 1510 EAVI---LPCTQTERNLSPSNSCEPKEESQSAPVQKNDSVVSVGTNN--VNTFQQEMKES 1564
+ L + ER+ + E K+ + +DS N +N + ++ E+
Sbjct: 1206 REHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNET 1265
Query: 1565 VI-----QTARQ-VRGRLQRPRPNIRKTGQRQIVDKGEAKGIIKEGRTILPKDE-TEKKV 1617
+ Q RQ V G L + + ++ + + G+ I E + P+ E +EK+
Sbjct: 1266 LTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVI--ENSDVSPETESSEKET 1323
Query: 1618 LTVSNSQIETEIEVPSSAVPEHRMYENQSQVVL 1650
++VS +Q T+++ AV + E + VL
Sbjct: 1324 MSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVL 1356
Score = 42.4 bits (98), Expect = 0.006
Identities = 179/962 (18%), Positives = 372/962 (38%), Gaps = 123/962 (12%)
Query: 1092 EETEREIS--PQENG-LEEVKPLGEMQTDLKATGREISPREKTPEVIDATEEIDKDLEET 1148
E+ E EI+ QENG L + Q + K + R+ D +++ E+T
Sbjct: 413 EQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQ------DYARLVNELTEKT 466
Query: 1149 GRREISPEENGPEEV--KPVDEMETDLKTTGREGSSR--EKTREVIDAAEVIETDLEETE 1204
G+ + EEV K ++ T LK +E R E + E ++ +
Sbjct: 467 GKLQ-------QEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQ 519
Query: 1205 REISPQENGPEEVKPVGKMETDLKEIREEISQREKVLAEFSAIREKEIDLKETGKRDIP- 1263
+ +EN EV+ + TD ++++ QR L + +K ++ +E+ + +
Sbjct: 520 SKFVAKEN---EVQSLHSKLTDTLVSKQQLEQR---LMQLMESEQKRVNKEESLQMQVQD 573
Query: 1264 IMEKVSGKMAVVEEMEADLKETGKENFRERGSEEICVTEEKVAELKQTGKTDISPREN-- 1321
I+E+ A +++ + + + + E V EK ++KQT + S R+
Sbjct: 574 ILEQNEALKAQIQQFHSQI--AAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLT 631
Query: 1322 ELEETSTSRQTDTHLMQSGSNDFSAVPSLDIQNISSEVLSMMHTPVEEKRNS-------- 1373
EE Q L+++ A+ + Q ++ L M V K +
Sbjct: 632 SKEEELKDIQNMNFLLKAEVQKLQALANE--QAAAAHELEKMQQSVYVKDDKIRLLEEQL 689
Query: 1374 EKEVSSHFSHFKISSQTHESDKTEVQGIQSPDVPEQFSDI--NLSKSLPQEQKPL----E 1427
+ E+S+ FKI + +++ K+EVQ +Q+ + D+ + K + ++ + L E
Sbjct: 690 QHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEE 749
Query: 1428 IKPAPFVRSRFKRPKPNLARAALKRETTESEKYIYEKKSETKKMETIVMQENNEQTDTLP 1487
+ ++ K + N A++ E + K + + K+ K+ + + E+ +
Sbjct: 750 LLETGLIQVATKEEELN----AIRTENSSLTKEVQDLKA--KQNDQVSFASLVEELKKVI 803
Query: 1488 SQHDEASLMISR--EKDTLGHRNEEAVILPCTQTERNLSPSNSCEPKEESQ----SAPVQ 1541
+ D + E + L N+E + Q + L E++Q ++ VQ
Sbjct: 804 HEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQ 863
Query: 1542 KNDSVVSVGTNNVNTFQQEMKESVIQTA------RQVRGRLQRPRPNIRKTGQRQIVDKG 1595
+ +++ +NT + ++E A + ++ + + ++++ Q + +
Sbjct: 864 ELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEAS 923
Query: 1596 EAKGIIKEGRTILPKDETEKK----VLTVSNSQIETEIEVPSSAVPEHRMYENQSQVVLV 1651
A +E +L + E E K +L S + ++ ++ E++++ +SQ+ +
Sbjct: 924 SASQ-FEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLF--KSQIEQL 980
Query: 1652 ENLHVNKTNETIRHENKPYVPSSAQMTRRKFQKAKPNLGRA--HSKKE------------ 1697
+ + + + HE V S + +L A H +K+
Sbjct: 981 KQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAM 1040
Query: 1698 ------EPVLEKVTTDQSKEGKPEDHLLQKGASNTQLLLKEK---------AELLTSLEV 1742
E +L+ SKE + + ++ A L K E L E
Sbjct: 1041 EALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEK 1100
Query: 1743 SARKDCVGSKESALAKI-DAELEEVGPSRRVGEETVGDNSPSSVVEEQYLNKL-TSCPQP 1800
A++ G+ S K+ + +L+E + + E L KL S Q
Sbjct: 1101 KAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQE 1160
Query: 1801 LN------ETSYSKIALDGKTTISSTSEYERNRGERR---SHKKFKPNVTRGRGSKRVRG 1851
N + S+ I + SS E ER R E + + ++ + ++ +
Sbjct: 1161 ENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMER 1220
Query: 1852 KTSKKEPRASKAMLVTLRASQEEDDDADDFESDYEEESYHLAPEEVNKAPVFVPVGLRSP 1911
T E R K +L L Q++ DD+ E+ + E +L ++N+ +
Sbjct: 1221 STYVTEVRELKDLLTEL---QKKLDDSYS-EAVRQNEELNLLKAQLNETLTKLRTEQNER 1276
Query: 1912 EPVSAQIEETMEELEITVN--VPDVGCIAVVEHELPNTDVTTE-EMKQEENLSVPFEMTT 1968
+ V+ + + + LE+ + V G V+E N+DV+ E E ++E +SV T
Sbjct: 1277 QKVAGDLHKAQQSLELIQSKIVKAAGDTTVIE----NSDVSPETESSEKETMSVSLNQTV 1332
Query: 1969 SE 1970
++
Sbjct: 1333 TQ 1334
>gi|153945728 microtubule-associated protein 1B [Homo sapiens]
Length = 2468
Score = 74.3 bits (181), Expect = 1e-12
Identities = 242/1263 (19%), Positives = 454/1263 (35%), Gaps = 178/1263 (14%)
Query: 375 LAEEEKRKQKSVKNHSLKEKKSTKPRKNV----KVKKVACEGVNN-DPDESMSSRISDTE 429
+ ++ K KQ++ SLK P K+V K + VN+ + + S+
Sbjct: 529 VVKQTKLKQRADSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPPKVESKEKVMV 588
Query: 430 RSQKDAQTVEEESLTL----SREDAEQVALEVDLNQKKRRRKKQDGANELGVNNLLENAT 485
+ K +T + S+T S+E+ V EV +K+ K A E V +
Sbjct: 589 KKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVA--EKQATDVKPKAAKEKTVK---KETK 643
Query: 486 VQAGPSKGEKHKNKCQAIRPE-----LKEGECSKEQMLS-CTQNIDGIVGFASTEKVEKR 539
V+ K EK K K + + E KE + KE++ + I ++V+K
Sbjct: 644 VKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKE 703
Query: 540 TDP--ILSLSNQQDATSVATESSESSTSDLPSFEVGIRALCEVNNAEGSCIEERNVDLKN 597
T P + +++ V E E + ++ ++ A+ + V K
Sbjct: 704 TPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKE 763
Query: 598 NSLEIDQTENVKPMLRGRFQRPKPNLSRA-GKKSVLSQGKTESESKNSHSKTSV---EKN 653
S++ D KP +G+ + K A + + G T + + ++ ++
Sbjct: 764 ESVKKDSVAAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKEL 823
Query: 654 HVEKDKMNTLDILRMETTERENPEAE-TVSVLGEKNCLQEGSQLKALRPVQVRGRLQKPK 712
E+ M++ + L + E + E + T + + +++ +LK PV+ ++ +
Sbjct: 824 EAERSLMSSPEDLTKDFEELKAEEVDVTKDIKPQLELIEDEEKLKETEPVEAYVIQKERE 883
Query: 713 PNAGKAAERKEILISQEEIGANVEKNENESCADR---DTPQHMEDQSRKDFEEEDVILQP 769
G A E + + E G + E ++ D + ED+ E +
Sbjct: 884 VTKGPAESPDEGITTTEGEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSETGDYE 943
Query: 770 EKNDSFQNVQPDEPKVLNECLSVQENNKANKLNQVPILRTRFQKPK-PNIGRGTGRREIS 828
EK ++ + +P+E + C+S +++ + + K ++ G R E
Sbjct: 944 EKAETEEAEEPEEDGEEHVCVSASKHSPTEDEESAKAEADAYIREKRESVASGDDRAE-E 1002
Query: 829 SKEEVLEKILVSGEMAAALRETVRLDTSPKEMVPAEINTKE------------------- 869
+E +EK A E D +E P ++ ++
Sbjct: 1003 DMDEAIEKGEAEQSEEEADEEDKAEDAREEEYEPEKMEAEDYVMAVVDKAAEAGGAEEQY 1062
Query: 870 --MQSDLKETGRRAISP-REKILDVIDDTIEMETGLKAMGREICLREKTPEVIDAT---- 922
+ + K+ G A SP RE + D+T+ + +A + RE PE AT
Sbjct: 1063 GFLTTPTKQLG--AQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYT 1120
Query: 923 --------EEIDKDLEEAGRREISPQKNGPEEVKPLGEVETDLKATGN-----ESSPREK 969
E D R +S + N E P E K + S P +
Sbjct: 1121 QSTIEISSEPTPMDEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPADV 1180
Query: 970 TP-------EVTDATEEIDKNLEETGRRKISPRENGPEEVKPVDEMETDLNATGRESSPR 1022
TP TDAT+ D N + ISP + ++E + +A
Sbjct: 1181 TPLNGFSEGSKTDATDGKDYNASAS---TISPPSS-------MEEDKFSRSALRDAYCSE 1230
Query: 1023 EKTPEVIDATEEIDLEETER-------EVSPQENGLEEVKPLGEMETDLKATGRDSFPRG 1075
K +D + I +E+ +SP E PLGE + T +
Sbjct: 1231 VKASTTLDIKDSISAVSSEKVSPSKSPSLSPSPPSPLEKTPLGERSVNFSLTPNEIKVSA 1290
Query: 1076 KTPEVIDAIEEIEIDLEETEREISPQENGLEEVKPLGEMQTDLKATGREISPREKT---- 1131
+ EV E+ ++ E E SP++ LE V P + T SP ++
Sbjct: 1291 EA-EVAPVSPEVTQEVVE-EHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHL 1348
Query: 1132 -------PEVIDATEEIDKDLEETGRREISP-EENGPEEVKPVDEMETDLKTTGREGSSR 1183
P + + E +E R +SP +E P+ P++++ + L++ GS
Sbjct: 1349 PTEVIEKPPAVPVSFEFSDAKDENERASVSPMDEPVPDSESPIEKVLSPLRSPPLIGSES 1408
Query: 1184 EKTREVIDAAEVIETDLEETEREISPQENGPEEVKPVGKM-ETDLKEIREEISQREKVLA 1242
+ + E E S ++ P++V PV +M T L + ++E +
Sbjct: 1409 AYESFLSADDKASGRGAESPFEEKSGKQGSPDQVSPVSEMTSTSLYQDKQEGKSTDFAPI 1468
Query: 1243 EFSAIREKEIDLKETGKRDIPIMEKVSGKMAVVEEMEADLKETGKENFRERGSEEICVTE 1302
+ +EK+ D E P + K+ V + D+ + G +F+E ++ ++E
Sbjct: 1469 KEDFGQEKKTDDVEAMSSQ-PALALDERKLGDVSPTQIDVSQFG--SFKE--DTKMSISE 1523
Query: 1303 EKVAELKQTGKTDISPRENELEETSTSRQTDTHLMQSGSNDFSAVPSLDIQNISSEVLSM 1362
V++ T P + + E + S + + S S+ P ++S + +
Sbjct: 1524 GTVSDKSAT------PVDEGVAEDTYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAE 1577
Query: 1363 MHTPVEEKRNSEKEVSSHFSHFKISSQTHESDKTEVQGIQSPDVPEQFSDINLSKSLPQE 1422
+ +P T D V +Q+P F + +S S +
Sbjct: 1578 VGSP---------------------HSTEVDDSLSVSVVQTPTT---FQETEMSPSKEEC 1613
Query: 1423 QKPLEIKPAPFVRSRFKRPKPNLARAALKRETTESEKYIYEKKSETKKMETIVMQENNEQ 1482
+P+ I P F PK T +S + + +SE M QE+ EQ
Sbjct: 1614 PRPMSISPPDF------SPK-----------TAKSRTPVQDHRSEQSSMSIEFGQESPEQ 1656
Query: 1483 TDTLPSQHDEASLMISREKDTLGHRNEEAVILPCTQ---TERNLSPSNSCEPKEESQSAP 1539
SL + + + H A +L T+ TE + SPS+ + + P
Sbjct: 1657 -----------SLAMDFSRQSPDHPTVGAGVLHITENGPTEVDYSPSDMQDSSLSHKIPP 1705
Query: 1540 VQK 1542
+++
Sbjct: 1706 MEE 1708
Score = 40.0 bits (92), Expect = 0.030
Identities = 102/554 (18%), Positives = 206/554 (37%), Gaps = 61/554 (11%)
Query: 1257 TGKRDIPIMEKVSGKMAVVEEMEADLKETGKENFRERGSEEICV-TEEKVAELKQTGKTD 1315
TG+ P++++ K AD +E+ K + S+ + ++E+ E+ + +
Sbjct: 522 TGQVPTPVVKQTKLKQ------RADSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVE 575
Query: 1316 ISPRENELEETSTSRQTDTHLMQSGSNDFSAVPSLDIQN-ISSEVLSMMHTPVEEKRNSE 1374
P+ E+ + S VPS + + + +EV T V+ K E
Sbjct: 576 KPPKVESKEKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKE 635
Query: 1375 KEVSSHFSHFKISSQTHESDKTEVQGIQSPDVPEQFSDINLSKSLPQEQKPLEIKPAPFV 1434
K V K ++ DK E + +V ++ + K E+KP + + V
Sbjct: 636 KTV-------KKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKK----EEKPKKEEVKKEV 684
Query: 1435 RSRFKRPKPNLARAALKRETTESE---KYIYEKKSETKKMETIVMQENNEQTDTLPSQHD 1491
+ K+ + + +K+ET E + E+K E KK E +E ++ LP
Sbjct: 685 KKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEE----KEPKKEIKKLPKDAK 740
Query: 1492 EASLMISREKDTLGHRNEEAVILPCTQTERNLSPSNSC---EPKEESQSAPVQKNDS--- 1545
++S +S K + A + P + +S +PKE+ + ++K
Sbjct: 741 KSSTPLSEAK-------KPAALKPKVPKKEESVKKDSVAAGKPKEKGKIKVIKKEGKAAE 793
Query: 1546 --VVSVGTN-NVNTFQQEMKESVIQTARQVRGR--LQRPRPNIRKTGQRQIVDKGEAKGI 1600
+VGT + I A+++ L ++ K + ++ +
Sbjct: 794 AVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKD 853
Query: 1601 IKEGRTILPKDETEKKVLTVSNSQIETEIEVPSSAV--PEHRMYENQSQVVLVENLHVNK 1658
IK ++ +E K+ V I+ E EV P+ + + + +
Sbjct: 854 IKPQLELIEDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTEGEG------ECEQ 907
Query: 1659 TNETIRHENKPYVPSSAQMTRRKFQKAKPNLGRAHSKKEEPVLEKVTTDQSKEGKP--ED 1716
T E + K V KF+ G S + EK T++++E + E+
Sbjct: 908 TPEELEPVEKQGVDDI-----EKFE--DEGAGFEESSETGDYEEKAETEEAEEPEEDGEE 960
Query: 1717 HLLQKGASNTQLLLKEKAELLTSLEVSARKDCVGSKESALAKIDAELEEVGPSRRVGEET 1776
H+ + ++ +E A+ + +++ V S + + E E G + + EE
Sbjct: 961 HVCVSASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSEEEA 1020
Query: 1777 VGDNSPSSVVEEQY 1790
++ EE+Y
Sbjct: 1021 DEEDKAEDAREEEY 1034
>gi|156104874 envoplakin [Homo sapiens]
Length = 2033
Score = 73.9 bits (180), Expect = 2e-12
Identities = 200/1065 (18%), Positives = 415/1065 (38%), Gaps = 144/1065 (13%)
Query: 545 SLSNQQDATSVATESSESSTSDLPSFEVGIRALCEVNNAEGSCIEERNVDLKNNSLEIDQ 604
+L + A + + + DLP + +RAL + +A G ++ R +++ +L Q
Sbjct: 695 ALKASEHACAALQNNFQEFCQDLPRQQRQVRALTDRYHAVGDQLDLREKVVQDAALTYQQ 754
Query: 605 TENVKPMLRGRFQ-------RPKPNLSRAGKKSVLSQGKTESESKNSHSKTSVEKNHVEK 657
+N K L + RP S+ K L K ++ S + +H+ +
Sbjct: 755 FKNCKDNLSSWLEHLPRSQVRPSDGPSQIAYK--LQAQKRLTQEIQSRERDRATASHLSQ 812
Query: 658 DKMNTLDILRMETTERENPEAETVSVLGEKNCLQEGSQLKALRPVQVRGRLQKPKPNAGK 717
L ++ T++V S K R ++ +Q + N K
Sbjct: 813 ALQAALQDYELQADTYRCSLEPTLAV----------SAPKRPRVAPLQESIQAQEKNLAK 862
Query: 718 A-----AERKEILISQEEIGANVEKNENESCADR--DTPQHMEDQSRKDFEEEDVILQ-P 769
A A ++++L E +EK E R D Q E ++ E E + Q
Sbjct: 863 AYTEVAAAQQQLLQQLEFARKMLEKKELSEDIRRTHDAKQGSESPAQAGRESEALKAQLE 922
Query: 770 EKNDSFQNVQPDEPKVLNECLSVQENNKANKLNQVPILRTRFQKPKPNIGRGTGRREISS 829
E+ VQ + ++ L ++ +L + ++ F + P + R +
Sbjct: 923 EERKRVARVQHELEAQRSQLLQLRTQRPLERLEEKEVVE--FYRD-PQLEGSLSRVKAQV 979
Query: 830 KEEVLEKILVSGEMAAALRETVRLDTSPKEMVPAEINTKEMQSDLKETG--RRAISPREK 887
+EE + + ++ A ++ V+L++ K M P + TKE+ ++ G +A R +
Sbjct: 980 EEEGKRRAGLQADLEVAAQKVVQLESKRKTMQP-HLLTKEVTQVERDPGLDSQAAQLRIQ 1038
Query: 888 ILDVI-DDTI------------------EMETGLKAMGREICLREKTPEVIDATEEIDKD 928
I + +D + E++ K + +E+ EK E++ A + +
Sbjct: 1039 IQQLRGEDAVISARLEGLKKELLALEKREVDVKEKVVVKEVVKVEKNLEMVKAAQALRLQ 1098
Query: 929 LEEAGRREISPQKNGPEEVKPLGEVETDLKATGNESSPREKTPEVTDATEEIDKNLEETG 988
+EE R +K E V L DL+ + P+ EV E+ L+E+
Sbjct: 1099 MEEDAAR----RKQAEEAVAKLQARIEDLERAISSVEPKVIVKEVKKV-EQDPGLLQESS 1153
Query: 989 RRKISPRENGPEEVKPVDEMETDLNA---TGRESSPREKTPEVIDATEEIDLEETEREVS 1045
R + E + E+ +DL++ + P+ + E + ++D ETE+E++
Sbjct: 1154 RLRSLLEEERTKNATLAREL-SDLHSKYSVVEKQRPKVQLQERVHEIFQVD-PETEQEIT 1211
Query: 1046 PQENGLEEV------------KPLGEMET--------DLKATGRDSFPRGKTPEVIDAIE 1085
+ L+E+ K L ++E + K ++ ++PEV+ I+
Sbjct: 1212 RLKAKLQEMAGKRSGVEKEVEKLLPDLEVLRAQKPTVEYKEVTQEVVRHERSPEVLREID 1271
Query: 1086 EIEIDLEETEREISPQENGLEEVKPLGEM--------QTDLKATGREISPREKTPEVIDA 1137
++ L E + L ++ GE + + K +E+ EK P +
Sbjct: 1272 RLKAQLNELVNSHGRSQEQL--IRLQGERDEWRRERAKVETKTVSKEVVRHEKDPVLEKE 1329
Query: 1138 TEEIDKDLEETGRREISPEENGPEEVKPVDEMETDLKTTGREGSSREKTREVIDAAEVIE 1197
E + +++ E ++ + E+ V E+++ R R K E + EV+
Sbjct: 1330 AERLRQEVREAAQKRRAAED-------AVYELQSK-----RLLLERRKPEEKVVVQEVVV 1377
Query: 1198 TDLEETEREISPQENGP--EEVKPVGKMETDLKEIREEISQRE----------KVLAEFS 1245
T + RE + +G EEV ++E +++++R + ++E K LA
Sbjct: 1378 TQKDPKLREEHSRLSGSLDEEVGRRRQLELEVQQLRAGVEEQEGLLSFQEDRSKKLAVER 1437
Query: 1246 AIREKEIDLKETGKRDIPIMEKVSGKMAVVEEMEADLKETGKENFRERGSEEICVTEEKV 1305
+R+ + ++E KR + EK+ + V E + DL+++ + + E+ VTE
Sbjct: 1438 ELRQLTLRIQELEKRPPTVQEKIIMEEVVKLEKDPDLEKSTEALRWDLDQEKTQVTELNR 1497
Query: 1306 AELKQTGKTDISPRENELEETSTSRQTDTHLMQSGSNDFSAVPSLDIQNISSEVLSMMHT 1365
+ D+ + E+T + ++ + V E+L+ T
Sbjct: 1498 ECKNLQVQIDVLQKAKSQEKTIYKEVIRVQKDRVLEDERARV---------WEMLNRERT 1548
Query: 1366 PVEEKRNSEKEVSSHFSHFKISSQTHESDKTEVQGIQSPDVPEQFSDINLSKSLPQEQKP 1425
+ + + + + +T +++E+Q ++ D +Q L QE +
Sbjct: 1549 ARQAREEEARRLRERIDRAETLGRTWSREESELQ--RARDQADQECG-----RLQQELRA 1601
Query: 1426 LEIKPAPFVRSRFKRPKPNLARAALKRETTESEKY-IYEKKSETKKMETIVMQENN---E 1481
LE R + ++ + L + TESE+ ++ E ++E +++E + E
Sbjct: 1602 LE-------RQKQQQTLQLQEESKLLSQKTESERQKAAQRGQELSRLEAAILREKDQIYE 1654
Query: 1482 QTDTLPSQHDEASL-MISREKDTLGHRNEEAVILPCTQTERNLSP 1525
+ TL H + S +S+E T + + +T +++SP
Sbjct: 1655 KERTLRDLHAKVSREELSQETQTRETNLSTKISILEPETGKDMSP 1699
Score = 56.6 bits (135), Expect = 3e-07
Identities = 163/857 (19%), Positives = 322/857 (37%), Gaps = 144/857 (16%)
Query: 610 PMLRGRFQRPKPNLSRAGKKSVLSQGKTESESKNSHSKTSVEKNHVEKDKMNTLDILRME 669
P L G R K + GK+ Q E ++ S K + + T ++ ++E
Sbjct: 966 PQLEGSLSRVKAQVEEEGKRRAGLQADLEVAAQKVVQLES--KRKTMQPHLLTKEVTQVE 1023
Query: 670 TTERENPEAETVSVLGEKNCLQEGSQLKALR--PVQVRGRLQKPKPNAGKAAERKEILIS 727
+ +A + + Q++ LR + RL+ K A E++E+ +
Sbjct: 1024 RDPGLDSQAAQLRI-----------QIQQLRGEDAVISARLEGLKKEL-LALEKREVDVK 1071
Query: 728 QEEIG---ANVEKNENESCADRDTPQHMEDQS--RKDFEEEDVILQPEKNDSFQNVQPDE 782
++ + VEKN A + ME+ + RK EE LQ D + + E
Sbjct: 1072 EKVVVKEVVKVEKNLEMVKAAQALRLQMEEDAARRKQAEEAVAKLQARIEDLERAISSVE 1131
Query: 783 PKVL-NECLSVQENNKANKLNQVPILRTRFQKPKPNIGRGTGRREIS---SKEEVLEKIL 838
PKV+ E V+++ L + LR+ ++ + T RE+S SK V+EK
Sbjct: 1132 PKVIVKEVKKVEQD--PGLLQESSRLRSLLEEERTK--NATLARELSDLHSKYSVVEKQR 1187
Query: 839 VSGEMAAALRETVRLDTSPKEMVPAEINTKEMQSDLKETGRRA----ISPREKILDVIDD 894
++ + E ++D ++ + + K + K +G + P ++L
Sbjct: 1188 PKVQLQERVHEIFQVDPETEQEI-TRLKAKLQEMAGKRSGVEKEVEKLLPDLEVLRAQKP 1246
Query: 895 TIEMETGLKAMGREICLREKTPEVIDATEEIDKDLEEA----GRRE---ISPQKNGPEEV 947
T+E K + +E+ E++PEV+ + + L E GR + I Q E
Sbjct: 1247 TVEY----KEVTQEVVRHERSPEVLREIDRLKAQLNELVNSHGRSQEQLIRLQGERDEWR 1302
Query: 948 KPLGEVETDLKATGNESSPREKTPEVTDATEEIDKNLEETGRRKISPRE----------- 996
+ +VET K E EK P + E + + + E +++ + +
Sbjct: 1303 RERAKVET--KTVSKEVVRHEKDPVLEKEAERLRQEVREAAQKRRAAEDAVYELQSKRLL 1360
Query: 997 ---NGPEEVKPVDEMETDLNATGRESSPREKTPEVIDATEEI--DLEETEREVSPQENGL 1051
PEE V E+ T ++ RE+ + + +E + E EV G+
Sbjct: 1361 LERRKPEEKVVVQEVVV----TQKDPKLREEHSRLSGSLDEEVGRRRQLELEVQQLRAGV 1416
Query: 1052 EEVKPLGEMETDL-----------------------------KATGRDSFPRGKTPEVID 1082
EE + L + D K + K P++
Sbjct: 1417 EEQEGLLSFQEDRSKKLAVERELRQLTLRIQELEKRPPTVQEKIIMEEVVKLEKDPDLEK 1476
Query: 1083 AIEEIEIDLEETEREISPQ----ENGLEEVKPLGEMQTDLKATGREISPREKTPEVIDAT 1138
+ E + DL++ + +++ +N ++ L + ++ K +E+ +K + D
Sbjct: 1477 STEALRWDLDQEKTQVTELNRECKNLQVQIDVLQKAKSQEKTIYKEVIRVQKDRVLEDER 1536
Query: 1139 EEIDKDLEETGRREISPEENGPEEVKPVDEMETDLKTTGREGSSREKTREVIDA-AEVIE 1197
+ + L + EE + +D ET +T RE S ++ R+ D ++
Sbjct: 1537 ARVWEMLNRERTARQAREEEARRLRERIDRAETLGRTWSREESELQRARDQADQECGRLQ 1596
Query: 1198 TDLEETEREISPQ-------------------ENGPEEVKPVGKMETDLKEIREEISQRE 1238
+L ER+ Q + + + + ++E + +++I ++E
Sbjct: 1597 QELRALERQKQQQTLQLQEESKLLSQKTESERQKAAQRGQELSRLEAAILREKDQIYEKE 1656
Query: 1239 KVLAEFSAIREKEIDLKETGKRDIPIMEKVSGKMAVVEEMEADLKETGKENFRERGSEEI 1298
+ L + A +E +ET R+ +S K++++E ETGK+ +
Sbjct: 1657 RTLRDLHAKVSREELSQETQTRE----TNLSTKISILE------PETGKDMSPYEAYKRG 1706
Query: 1299 CVTEEKVAELKQTGKTDISPRENELEETSTS---RQTDTHLMQSGSNDFSAVPSLDIQNI 1355
+ + +L++ E + EE +TS + L + +S +L + I
Sbjct: 1707 IIDRGQYLQLQEL--------ECDWEEVTTSGPCGEESVLLDRKSGKQYSIEAALRCRRI 1758
Query: 1356 SSEVLSMM---HTPVEE 1369
S E + H P+ E
Sbjct: 1759 SKEEYHLYKDGHLPISE 1775
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 73.6 bits (179), Expect = 2e-12
Identities = 210/997 (21%), Positives = 380/997 (38%), Gaps = 174/997 (17%)
Query: 542 PILSLSNQQDATSVATESSESSTSDLPSFEVGIRALCEVNNAEGSCIEERN-----VDLK 596
P+L + + + E + + +L E + E+ + ++E+N V +
Sbjct: 839 PLLKSAETEKEMATMKEEFQKTKDELAKSEAKRK---ELEEKLVTLVQEKNDLQLQVQAE 895
Query: 597 NNSLEIDQTENVKPMLRGRFQ---RPKPNLSRAGKKSVLSQGKTESESKNSHSKTSVEKN 653
+ +L +D E +++ +FQ + K RA + ++ T + K + ++K+
Sbjct: 896 SENL-LDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKD 954
Query: 654 ---------HVEKDKMNTLDILRMETTERENPEAETVSVLGEKNCLQEGSQLKALRPVQV 704
VEK+K T + ++ T E + + EK LQE Q +AL +Q
Sbjct: 955 IDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQ-QALDDLQA 1013
Query: 705 R----GRLQKPKPNAGKAAERKEILISQE-EIGANVEKNENESCADRDTPQHMEDQSRKD 759
L K K + E E + QE ++ ++E+N+ + D Q D
Sbjct: 1014 EEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLEND 1073
Query: 760 FEEEDVILQPEKNDSFQNVQPDEPKVLNECLSVQENNKANKLN------QVPILRTRFQK 813
++ D L K F+ Q + L +Q K +L + I R +
Sbjct: 1074 KQQLDERL---KKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATR 1130
Query: 814 PKPNIGRGTGRREISSKEEVLEKILVSGEMAAA--------------LRETVRLDTSPKE 859
K R RE+ EE+ E++ +G + + LR + T E
Sbjct: 1131 AKTEKQRSDYAREL---EELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHE 1187
Query: 860 MVPAEINTKEMQS------------DLKETGRRAISPREKILDVIDDTIEMETGLKAMGR 907
+ A + K S +K+ + S + +D + ++E + KA
Sbjct: 1188 AMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLE 1247
Query: 908 EIC--LREKTPEVIDATEEIDKDLEEAGRREISPQKNGPEEVKPLGEVETDLKATGNESS 965
+IC L ++ E EEI + L E ++ Q E + L E E+ + S
Sbjct: 1248 KICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIV------SQ 1301
Query: 966 PREKTPEVTDATEEIDKNLEETGRRKIS--------------PRENGPEEVKPVDEMETD 1011
T TEE+ + LEE + K + RE EE + E++
Sbjct: 1302 LSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRA 1361
Query: 1012 LN---------ATGRESSPREKTPEVIDATEEI-----DLEETEREVSPQENGLEEVKP- 1056
L+ T E+ ++T E+ +A +++ D EE V+ + LE+ K
Sbjct: 1362 LSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQR 1421
Query: 1057 -LGEME---TDLKATGRDSFPRGKTPEVIDAI--------EEIEIDLEETEREISPQENG 1104
GE+E D++ + K D + EE + +LE + +E
Sbjct: 1422 LQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTE 1481
Query: 1105 LEEVKPLGEMQTD-LKATGREISPREKTPEVIDATEEIDKDLE-----ETGRREISPE-- 1156
L ++K E D L+ RE E+ E+ D TE+I ++ + E R++I E
Sbjct: 1482 LFKLKNAYEEALDQLETVKRENKNLEQ--EIADLTEQIAENGKTIHELEKSRKQIELEKA 1539
Query: 1157 --ENGPEEVKPVDEME------TDLKTTGREGSSREKTREVIDAAEVIETDLEETEREI- 1207
+ EE + E E L+ T + K E + E ++ + + T +
Sbjct: 1540 DIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQ 1599
Query: 1208 ----SPQENGPEEVKPVGKMETDLKEIREEISQREKVLAE-FSAIREKEIDLKETG---- 1258
+ + E ++ KME DL EI ++S + AE +R + LK+T
Sbjct: 1600 SALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLD 1659
Query: 1259 ---------KRDIPIMEKVSGKM-AVVEEMEADLKETGKENFRERGSEEICVTEEKVAEL 1308
K + I+E+ + + A VEE+ A L++T E R+ +E+ + E+V +L
Sbjct: 1660 DALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQT--ERARKLAEQELLDSNERV-QL 1716
Query: 1309 KQTGKTDISPRENELEETSTSRQTDTHLMQSGSNDFSAVPSLDIQNISSEVLSMM--HTP 1366
T T + + +LE TD +QS D S D +N + +
Sbjct: 1717 LHTQNTSLIHTKKKLE-------TDLMQLQSEVED----ASRDARNAEEKAKKAITDAAM 1765
Query: 1367 VEEKRNSEKEVSSHFSHFK------ISSQTHESDKTE 1397
+ E+ E++ S+H K + H D+ E
Sbjct: 1766 MAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAE 1802
Score = 63.9 bits (154), Expect = 2e-09
Identities = 212/1105 (19%), Positives = 428/1105 (38%), Gaps = 162/1105 (14%)
Query: 710 KPKPNAGKAAERKEILISQEEIGANVEKNENESCADRDTPQHMEDQSRKDFEEEDVILQP 769
K KP A KE+ +EE +K ++E + RK+ EE+ V L
Sbjct: 836 KIKPLLKSAETEKEMATMKEEF----QKTKDELAKS--------EAKRKELEEKLVTLVQ 883
Query: 770 EKNDSFQNVQPDEPKVLNECLSVQENNKAN-----KLNQVPILRTRFQKPKPNIGRGTGR 824
EKND VQ + +L+ + KA K+ +V + + N +
Sbjct: 884 EKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEV--TERAEDEEEINAELTAKK 941
Query: 825 REISSKEEVLEKILVSGEMAAALRETVRLDTSPKEMVPAEINTKEMQSDLKETGRRAISP 884
R++ + L+K + E+ A E + T K N E S L ET +
Sbjct: 942 RKLEDECSELKKDIDDLELTLAKVEKEKHATENKVK-----NLTEELSGLDETIAKLTRE 996
Query: 885 REKILDVIDDTIEMETGLKAMGREICLREKTPEVID-ATEEIDKDLEEAGRREISPQKNG 943
++ + + ++ L+A ++ KT ++ E+++ LE+ + + ++N
Sbjct: 997 KKALQEAHQQALD---DLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERN- 1052
Query: 944 PEEVKPLGEVETDLKATGNESSPREKTPEVTDATEEIDKNLEETGRRKISPRENGPEEVK 1003
++E DLK +E ++ + +++D+ L K E + K
Sbjct: 1053 ------KRKLEGDLKLA------QESILDLENDKQQLDERL------KKKDFEYCQLQSK 1094
Query: 1004 PVDEMETDLNATGRESSPREKTPEVIDATEEIDLEETEREVSPQENGLEEVKPLGEMETD 1063
DE L + +E + + EEI+ E R + ++ + + L E+
Sbjct: 1095 VEDEQTLGLQF---QKKIKELQARIEELEEEIEAERATRAKTEKQRS-DYARELEELSER 1150
Query: 1064 LKATGRDSFPRGKTPEVIDAIEEIEIDLEETEREISPQENGLEEVKPLGEMQTDLKATGR 1123
L+ G G T I+ ++ E + + R++ + L+
Sbjct: 1151 LEEAG------GVTSTQIELNKKREAEFLKLRRDLE---------------EATLQHEAM 1189
Query: 1124 EISPREKTPEVIDATEEIDKDLEETGRREISPEENGPEEVKPVDEMETDLKTTGREGSSR 1183
+ R+K D+ E+ + ++ R + E+ E +D++ + +++ + ++
Sbjct: 1190 VAALRKKH---ADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANL 1246
Query: 1184 EK-TREVIDAAEVIETDLEETEREISPQENGPEEVKPVGKMETDLKEIREEISQREKVLA 1242
EK R + D EE +R +S E +++T+ E+ ++ ++E +++
Sbjct: 1247 EKICRTLEDQLSEARGKNEEIQRSLS------ELTTQKSRLQTEAGELSRQLEEKESIVS 1300
Query: 1243 EFSAIREKEIDLKETGKRDIPIMEKVSGKMAVVEEMEA-----DLKETGKENFRERGSE- 1296
+ S R K+ ++T + + E+ K A+ +++ DL E +E +E
Sbjct: 1301 QLS--RSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAEL 1358
Query: 1297 --EICVTEEKVAELKQTGKTDISPRENELEETS---TSRQTDTHLMQSGSNDFSAVPSLD 1351
+ +VA+ + +TD R ELEE R D+ N A
Sbjct: 1359 QRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKT 1418
Query: 1352 IQNISSEVLSMMHTPVEEKRNSEKEVSSHFSHF-KISSQTHESDKTEVQGIQSPDVPEQF 1410
Q + EV +M VE + + +F K+ ++ KT+ + Q+ E
Sbjct: 1419 KQRLQGEVEDLM-VDVERANSLAAALDKKQRNFDKVLAEW----KTKCEESQA----ELE 1469
Query: 1411 SDINLSKSLPQEQKPLE--IKPAPFVRSRFKRPKPNLAR--AALKRETTESEKYIYEKKS 1466
+ + S+SL E L+ + A KR NL + A L + E+ K I+E +
Sbjct: 1470 ASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEK 1529
Query: 1467 ETK--KMETIVMQENNEQTDTLPSQHDEASLM--------ISREKD-TLGHRNEEAVILP 1515
K ++E +Q E+ + +H+EA ++ + E D + ++EE
Sbjct: 1530 SRKQIELEKADIQLALEEAEA-ALEHEEAKILRIQLELTQVKSEIDRKIAEKDEE----- 1583
Query: 1516 CTQTERNLSPSNSCEPKEESQSAPVQKNDSVVSVG---TNNVNTFQQEMKESVIQTA--- 1569
Q +RN + E + + A V+ + + + ++N + ++ + Q A
Sbjct: 1584 IEQLKRNY--QRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETL 1641
Query: 1570 ---RQVRGRLQRPRPNIRKTGQRQIVDKGEAKGIIKEGRTILPKDETEKKVLTVSNSQIE 1626
R V+G+L K Q + D + +KE I+ E +L ++
Sbjct: 1642 KHLRSVQGQL--------KDTQLHLDDALRGQEDLKEQLAIV---ERRANLLQAEVEELR 1690
Query: 1627 TEIEVPSSA--VPEHRMYENQSQVVLVEN-----LHVNKTNETIRHENKPYVPSSAQMTR 1679
+E A + E + ++ +V L+ +H K ET + + V +++ R
Sbjct: 1691 ATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDAR 1750
Query: 1680 RKFQKAKPNLGRAHSKKEEPVLEKVTTDQSKEGKPEDHLLQKGASNTQLLLKEKAELLTS 1739
+KAK + A EE E+ T+ + ++K T L+ + +
Sbjct: 1751 NAEEKAKKAITDAAMMAEELKKEQDTSAHLER-------MKKNLEQTVKDLQHRLDEAEQ 1803
Query: 1740 LEVSARKDCVGSKESALAKIDAELE 1764
L + K + E+ + +++ ELE
Sbjct: 1804 LALKGGKKQIQKLETRIRELEFELE 1828
Score = 60.8 bits (146), Expect = 2e-08
Identities = 127/663 (19%), Positives = 243/663 (36%), Gaps = 73/663 (11%)
Query: 1152 EISPEENGPEEVKPVDEMETDLKTTGREGSSREKTREVIDAAEVI----ETDLE-----E 1202
+I P E K + M+ + + T E + E R+ ++ V + DL+ E
Sbjct: 836 KIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAE 895
Query: 1203 TEREISPQENGPEEVKPVGKMETDLKEIREEISQREKVLAEFSAIREKEIDLKETGKRDI 1262
+E + +E + +K ++E +KE+ E E++ AE +A + K D K+DI
Sbjct: 896 SENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDI 955
Query: 1263 PIMEKVSGKMAVVEEMEADLKETGKENFRERGSEEICVTEEKVAELKQTGKTDISPRENE 1322
+E K+ E E E +N +EE+ +E +A+L + K +
Sbjct: 956 DDLELTLAKV----EKEKHATENKVKNL----TEELSGLDETIAKLTREKKALQEAHQQA 1007
Query: 1323 LEETSTSRQTDTHLMQSGSNDFSAVPSLDIQNISSEVLSMMHTPVEEKRNSEKEVSSHFS 1382
L++ L N + ++++ S + V+ +RN K +
Sbjct: 1008 LDDLQAEEDKVNSL-----NKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRK-LEGDLK 1061
Query: 1383 HFKISSQTHESDKTEVQ-----------GIQSPDVPEQFSDINLSKSLPQEQKPLEIKPA 1431
+ S E+DK ++ +QS EQ + K + + Q +E
Sbjct: 1062 LAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEE 1121
Query: 1432 PFVRSRFKRPKPNLARAALKRETTESEKYIYEKKSETKKMETIVMQENNEQTDTLPSQHD 1491
R R K R+ RE E + + E T T + + + L + D
Sbjct: 1122 EIEAERATRAKTEKQRSDYARELEELSERLEEAGGVT---STQIELNKKREAEFLKLRRD 1178
Query: 1492 --EASLMISREKDTLGHRNEEAVILPCTQTERNLSPSNSCEPKEESQSAPVQK-NDSVVS 1548
EA+L L ++ ++V Q + E ++ + + S+ S
Sbjct: 1179 LEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMES 1238
Query: 1549 VGTNNVNTFQ-QEMKESVIQTARQVRGRLQRPRPNIRKTGQRQIVDKGEAKGIIKEGRTI 1607
V + N + E + AR +QR + R + GE ++E +I
Sbjct: 1239 VSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESI 1298
Query: 1608 LPKDETEKKVLTVSNSQIETEIEVPSSAVPE---------------HRMYENQSQVVLVE 1652
+ + K+ T +++ ++E + A YE + +
Sbjct: 1299 VSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAEL 1358
Query: 1653 NLHVNKTNETIRHENKPYVPSSAQMTRRKFQKAKPNLGRAHSKKEEPV---------LEK 1703
++K N + Y + Q T + ++AK L + EE V LEK
Sbjct: 1359 QRALSKANSEVAQWRTKYETDAIQRT-EELEEAKKKLAQRLQDSEEQVEAVNAKCASLEK 1417
Query: 1704 VTTDQSKEGKPEDHLLQ-KGASNTQLLLKEKAELLTSLEVSARKDCVGSKESALAKIDAE 1762
T Q +G+ ED ++ + A++ L +K + + C E + A+++A
Sbjct: 1418 --TKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKC----EESQAELEAS 1471
Query: 1763 LEE 1765
L+E
Sbjct: 1472 LKE 1474
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 73.6 bits (179), Expect = 2e-12
Identities = 294/1640 (17%), Positives = 606/1640 (36%), Gaps = 176/1640 (10%)
Query: 134 KEKQPCSDRYRIYKAQKLREMLKEELRKEKKQWKNKYAINESQRPPDRSKMTMRDFIYYL 193
+ +Q ++ + Q+LR +++LR+E+++ +++ +E +R R K + +L
Sbjct: 402 RREQQLRREQQLRREQQLRR--EQQLRREQEEERHEQK-HEQERREQRLKREQEERRDWL 458
Query: 194 PDNNPMTSSLEQEKKTEKPSTPVQTREQEGKSTPNAEDNEMEEETDDGPLLVPRVKVAED 253
T EQE++ ++ + +E E+ ++E + L + + E
Sbjct: 459 KREEE-TERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQ 517
Query: 254 GSIILDEESLTVEVLRTKGPCVVEEND---PIFERGSTTTYSSFRKNYYSKPWSNKETDM 310
+EE + LR++ E+ + + +R R+ K + D
Sbjct: 518 RLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQ 577
Query: 311 FFLAISMVGTDFSMIGQLFPHRARIEIKNKFKREEKTNGWRIDKAFQEKRPFDFDFFAHL 370
++ + Q ++ + KREE +++ QE+R
Sbjct: 578 ------LLKREEERRQQRLKREQEERLEQRLKREE------VERLEQEERRE-------- 617
Query: 371 LQKVLAEE--EKRKQKSVKNHSLKEKKSTKPRKNVKVKKVACEGVNNDPDESMSSRISDT 428
Q++ EE E+R+Q+ +K+ +E++ + R+ + ++ + +E + R+
Sbjct: 618 -QRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQ-RLKREEEEERLEQRLKRE 675
Query: 429 ERSQKDAQTVEEESLTLSREDAE--------QVALEVDLNQKK--RRRKKQDGANELGVN 478
++ Q + EE +RE + Q+ E D Q K R +KQ+G
Sbjct: 676 HEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRR---- 731
Query: 479 NLLENATVQAGPSKGEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGIVGFASTEKVEK 538
+ ++ K + + + +E E + Q Q D + + EK E+
Sbjct: 732 ------------RQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSER 779
Query: 539 RTDPILS---LSNQQDATSVATESSESSTSDLPSFEVGIRALCEVNNAEGSCI---EERN 592
+ + L Q++ A E + LP E + + E EE
Sbjct: 780 GRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQ 839
Query: 593 VDLKNNSLEIDQTENVKPMLRGRFQRPKPNLSRAGKKSVLSQGKTESESKNSHSKTSVEK 652
+ + + ++ + E+ G + + S+ ++ + + E E K T K
Sbjct: 840 LQRRERAQQLQEEED------GLQEDQERRRSQEQRRDQKWRWQLEEERKRRRH-TLYAK 892
Query: 653 NHVEKDKMNTLDILRMETTERENPEAETVSVLGEKNCLQEGSQLKALRPVQVRGRLQKPK 712
+++ +L+ E E + E E ++ +E QL+ +R +K +
Sbjct: 893 PALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRR 952
Query: 713 PNAGKAAERKEILISQEEIGANVEKNENESCADRDTPQHMEDQSRKDFEEEDVILQPEKN 772
+ RK+ + Q+E E+ E +R+ E++ + +EE+ +L+ E+
Sbjct: 953 RQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQ---QEEEQLLREERE 1009
Query: 773 DSFQNVQPDEPKVLNECLSVQENNKANKLNQVPILRTRFQKPKPNIGRGTGRREISSKEE 832
+ + + +E +E +LR +K + R E ++E
Sbjct: 1010 KRRRQEWERQYRKKDELQQEEEQ----------LLREEREKRRLQERERQYREEEELQQE 1059
Query: 833 VLEKILVSGEMAAALRETVRLDTSPKEMVPAEINTKEMQSDLKETGRRAISPREKILDVI 892
E+ L+ E R+ + +E E+ +E Q +E +R RE+
Sbjct: 1060 --EEQLLGEERETRRRQELERQYRKEE----ELQQEEEQLLREEPEKRRRQERERQCREE 1113
Query: 893 DDTIEMETGLKAMGREICLREKTPEVIDATEEIDKDLEEAGRREISPQKNGPEEVKPLGE 952
++ + E L RE R++ EE+ ++ E+ R E P+K +E++
Sbjct: 1114 EELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREE--PEKRRRQELERQYR 1171
Query: 953 VETDLKATGNESSPREKTPEVTDATEEIDKNLEETGRRKISPR---ENGPEEVKPVDEME 1009
E +L+ E RE+ + E + EE R+K R E+ ++K E E
Sbjct: 1172 EEEELQQE-EEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPE 1230
Query: 1010 TD-------LNATGRESSP--------------REKTPEVIDATEEIDLEETEREVSPQE 1048
+ + GRE+ ++ ++ +E D E+ R ++
Sbjct: 1231 KENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRD 1290
Query: 1049 NGLEEVKPLGEMETDLKATGRDSFPRGKTPEVIDAIEEIEIDLEETEREISPQENGLEE- 1107
E + L E E +A RD + + + + EE + +ET+R+ +E L+E
Sbjct: 1291 RHFPEEEQL-EREEQKEAKRRDRKSQEEKQLLREEREE-KRRRQETDRKFREEEQLLQER 1348
Query: 1108 -VKPLGEMQTDLKATGREISPREKTPEVIDATEEIDKDLEETGRREISPEENGPEEVKPV 1166
+PL + D K E+ +E+ + ++ + + + +E R+ + E+
Sbjct: 1349 EEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRR--QERERKFLKEEQQ-------- 1398
Query: 1167 DEMETDLKTTGREGSSREKTREVIDAAEVIETDLEETEREISPQENGP---EEVKPVGKM 1223
L+ RE R+ + E E+++S QE EE + V +
Sbjct: 1399 ------LRCQEREQQLRQDR----------DRKFREEEQQLSRQERDRKFREEEQQVRRQ 1442
Query: 1224 ETDLKEIREEISQREKVLAEFSAIREKEIDLKETGKRDIPIMEKVSGKMAVVEEMEADLK 1283
E + K + EE R++ +F RE+E L+E ++ + E+ +EE + +
Sbjct: 1443 ERERKFLEEEQQLRQERHRKF---REEEQLLQEREEQQLHRQER---DRKFLEEEQQLRR 1496
Query: 1284 ETGKENFRERGSEEICVTEEKVAELKQTGKTDISPRENE-LEETSTSRQTDTHLMQSGSN 1342
+ FRE +E+ E + L++ + R+ + L+E R+ + +
Sbjct: 1497 QERDRKFRE---QELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDR 1553
Query: 1343 DFSAVPSLDIQNISSEVLSMMHTPVEEKRNSEKEVSSHFSHFKISSQTHESDKTEVQGIQ 1402
D ++ E + R E++V K + + E Q
Sbjct: 1554 DRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQL 1613
Query: 1403 SPDVPEQFSDINLSKSLPQEQKPLEIKPAPFVRSRFKRPKPNLARAALKRETTESEKYIY 1462
+ +F + + L QE++ ++ R +F +P L R E E+ +
Sbjct: 1614 RQERDRKFRE---DEQLLQEREEQQLHRQERDR-KFLEEEPQLRRQ-------EREQQLR 1662
Query: 1463 EKKSETKKMETIVMQENNEQTDTLPSQHDEASLMISREKDTLGHRNEEAVILPCTQTERN 1522
+ + E ++QE EQ + E E+ L + E L Q R
Sbjct: 1663 HDRDRKFREEEQLLQEGEEQQ----LRRQERDRKFREEEQQLRRQERERKFLQEEQQLRR 1718
Query: 1523 LSPSNSCEPKEESQSAPVQKNDSVVSVGTNNVNTFQQEMKESVIQTARQVRGRLQRPRPN 1582
+E+ + Q+ + Q + Q RQ R R R
Sbjct: 1719 QELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQ 1778
Query: 1583 IRKTGQRQIVDKGEAKGIIKEGRTILPKDETEKKVLTVSNSQIETEIEVPSSAVPEHRMY 1642
+R+ + Q + E+ +E + + E ++ + + E E E R+
Sbjct: 1779 LRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLR 1838
Query: 1643 ENQSQVVLVENLHVNKTNETIRHENKPYVPSSAQMTRRKFQKAKPNLGRAHSKKEEPVLE 1702
+ + + E T E R E + Q R++ ++ +KEE
Sbjct: 1839 QERDRQYRAEEQFA--TQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHR 1896
Query: 1703 KVTTDQSKEGKPEDHLLQKG 1722
+V +S+EGK LL+ G
Sbjct: 1897 QVGEIKSQEGKGHGRLLEPG 1916
Score = 57.8 bits (138), Expect = 1e-07
Identities = 185/1117 (16%), Positives = 415/1117 (37%), Gaps = 93/1117 (8%)
Query: 634 QGKTESESKNSHSKTSVEKNHVEKDKMNTLDILRMETTERENPEAETVSVLGEKNCLQEG 693
+G+ E + + + V + EK+ +LR E + + E + ++ +E
Sbjct: 221 KGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQR-----QRELQEEE 275
Query: 694 SQLKALRPVQVRGRLQKPKPNAGKAAERKEILISQEEIGANVEKNENESCADRDTPQHME 753
QL+ L ++R Q+ + + +++ QEE ++ E R+ +
Sbjct: 276 EQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERR 335
Query: 754 DQSRKDFEEEDVILQPEKNDSFQNVQPDEPKVLNECLSVQENNKANKLNQVPILRTRFQK 813
+Q + +EE + + Q +E + +E + +L + LR Q
Sbjct: 336 EQQLRREQEE------RREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQL 389
Query: 814 PKPNIGRGTGRREISSKEEVLEKILVSGEMAAALRETVRLDTSPKEMVPAEINTKEMQSD 873
+ +++ ++++ + + E + +R + + E + ++ + +
Sbjct: 390 RR--------EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQE 441
Query: 874 LKETGRRAISPREKILDVIDDTIEMETGLKAMGREICLREKTPEVIDATEEIDKDLEEAG 933
+E +R +E+ D + E E + ++ R++ E E LEE
Sbjct: 442 RRE--QRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEE----RRERWLKLEEEE 495
Query: 934 RREISPQKNGPEEVKPLGEVETDLKATGNESSPREKTPEVTDATEEIDKNLEETGRRKIS 993
RRE ++ + E LK E +++ E ++ E+ +R
Sbjct: 496 RREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKR--- 552
Query: 994 PRENGPEEVKPVDEMETDLNATGRESSPREKTPEVIDATEEIDLEETEREVSPQENGLEE 1053
EE K +++ + + R++ + + + L+ + E Q EE
Sbjct: 553 ------EEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREE 606
Query: 1054 VKPLGEMETDLKATGRDSFPRGKTPEVIDAIEEIEIDLEETEREISPQENGLEEVKPLGE 1113
V+ L + E + R+ + +++ + E+ E ++ RE QE + +K E
Sbjct: 607 VERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRRE--QQERREQRLKREEE 664
Query: 1114 MQTDLKATGREISPREKTPEVIDATEEIDKDLEETGRREISPEENGPEEVKPVDEMETDL 1173
+ + RE + E+ EE + E + I + E + +
Sbjct: 665 EERLEQRLKREHEEERREQEL---AEEEQEQARERIKSRIPKWQWQLESEADARQSKVYS 721
Query: 1174 KTTGREGSSREKTREVIDAAEVIETDLEETEREISPQENGPEEVKPVGKMETDLKEIREE 1233
+ +EG R + +E + E++L+ E E + ++ EE + + +E E
Sbjct: 722 RPRKQEGQRRRQEQE--EKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSER 779
Query: 1234 ISQREKVLAEFSAIREKEIDLKETGKRD---IPIMEKVSGKMAVVEEMEADLK--ETGKE 1288
QR RE+++ +E +R+ +P E+ + E E +L+ E ++
Sbjct: 780 GRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQ 839
Query: 1289 NFRERGSEEICVTEEKVAELKQTGKTDISPREN----ELEETSTSRQTDTHLMQSGSNDF 1344
R ++++ E+ + E ++ ++ R+ +LEE R+ +
Sbjct: 840 LQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRR----------HTL 889
Query: 1345 SAVPSLD-----IQNISSEVLSMMHTPVEEKRNSEKEVSSHFSHFKISSQTHESDKTEVQ 1399
A P+L Q + E + EKR +++ + ++ + + + E +
Sbjct: 890 YAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREERE 949
Query: 1400 GIQSPDVPEQFSDINLSKSLPQEQKPLEIKPAPFVRSRFKRPKPNLARAALKRETTESEK 1459
+ + Q+ K L Q+++ L + P R R +R K L++ E E+
Sbjct: 950 KRRRQERERQY---RKDKKLQQKEEQL-LGEEPEKRRRQEREKKYREEEELQQ---EEEQ 1002
Query: 1460 YIYEKKSETKKMETIVMQENNEQTDTLPSQHDEASLMISREKDTLGHRNEEAVILPCTQT 1519
+ E++ + ++ E + + D L Q +E L REK L R + +
Sbjct: 1003 LLREEREKRRRQE---WERQYRKKDEL-QQEEEQLLREEREKRRLQERERQ------YRE 1052
Query: 1520 ERNLSPSNSCEPKEESQSAPVQKNDSVVSVGTNNVNTFQQEMKESVIQTARQVRGRLQRP 1579
E L EE ++ Q+ + +Q ++E + RQ R R R
Sbjct: 1053 EEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCRE 1112
Query: 1580 RPNIRKTGQRQIVDKGEAKGIIKEGRTILPKDETEKKVLTVSNSQIETEIEVPSSAVPEH 1639
+++ ++ + ++ E K R L + E++ + Q+ E
Sbjct: 1113 EEELQQEEEQLLREERE-----KRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELE 1167
Query: 1640 RMYENQSQVVLVENLHVNKTNETIRHENKPYVPSSAQMTRRKFQKAKPNLGRAHSKKEEP 1699
R Y + ++ E + + E R E + ++ R+K ++ R + +
Sbjct: 1168 RQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQ------RYRDEDQRS 1221
Query: 1700 VLEKVTTDQSKEGKPEDHLLQKGASNTQLLLKEKAEL 1736
L+ + + ++ + KG N Q E ++L
Sbjct: 1222 DLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQL 1258
Score = 41.2 bits (95), Expect = 0.014
Identities = 117/633 (18%), Positives = 232/633 (36%), Gaps = 70/633 (11%)
Query: 1014 ATGRESSPREKTPEVIDATEEIDLEETEREVSPQENGLEEV------KPLGEMETDLKAT 1067
ATG + R + ++ EE +R P++ LEE + E E +L A
Sbjct: 92 ATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQEREL-AE 150
Query: 1068 GRDSFPRGKTPEVIDAIEEIEIDLEETEREISPQENGLEEVKPLGEMQ------------ 1115
G + + + E D E +L +E +E E + L +
Sbjct: 151 GEEQSEKQERLEQRDRQRRDE-ELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQ 209
Query: 1116 ------TDLKATGREISP---REKTPEVIDATEEIDKDLEET--GRREISPEENGPEEVK 1164
+L+ GRE RE+ V EE + ET + E +E P+ +
Sbjct: 210 LRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQR 269
Query: 1165 PVDEMETDLKTTGREGSSREKTREV-----IDAAEVIETDLEETEREISPQENGPEEVKP 1219
+ E E L+ R+ RE+ E + + + EE RE + +E +
Sbjct: 270 ELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERRE 329
Query: 1220 VGKMETDLKEIREEISQREKVLAEFSAIREKEIDLKETGKRDIPIMEKVSGKMAVVEEME 1279
+ + + RE+ +RE+ L RE+E + +E R E+ ++ +++
Sbjct: 330 QQEERREQQLRREQEERREQQLR-----REQEEERREQQLRREQEEERREQQLRREQQLR 384
Query: 1280 ADLKETGKENFRERGSEEICVTEEKVAELKQTGKTDISPRENEL-EETSTSRQTDTHLMQ 1338
+ + ++ R E+ E+++ +Q + RE +L E R H +
Sbjct: 385 REQQLRREQQLRR---EQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQE 441
Query: 1339 SGSNDFSAVPSLDIQNISSEVLSMMHTPVEE----KRNSEKEVSSHFSHFKISSQTHESD 1394
+ E + H KR+ E+E + + + + +
Sbjct: 442 RREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQE 501
Query: 1395 KTEVQGIQSPDVPEQFSDINLSKSLPQEQKPLEIKPAPFVRSRFKRPKPNLARAALKRET 1454
+ E Q + E+ + L + +E+ ++ + +R + LKRE
Sbjct: 502 RREQQLRRE---QEERREQRLKRQEEEERLQQRLRS----EQQLRREQEERREQLLKREE 554
Query: 1455 TESEKYIYEKKSETKKMETIVMQENNEQTDTLPSQHDE--ASLMISREKDTLGHRNEEAV 1512
EK+ E ++ E + +E E+ D L + +E + +++ L R +
Sbjct: 555 --------EKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREE 606
Query: 1513 ILPCTQTERNLSPSNSCEPKEESQSAPVQKNDSVVSVGTNNVNTFQQEMKESVI---QTA 1569
+ Q ER EP+EE + + K++ + QQE +E + +
Sbjct: 607 VERLEQEERREQRLKREEPEEERRQ-QLLKSEEQEERRQQQLRREQQERREQRLKREEEE 665
Query: 1570 RQVRGRLQRPRPNIRKTGQRQIVDKGEAKGIIK 1602
++ RL+R R+ + ++ +A+ IK
Sbjct: 666 ERLEQRLKREHEEERREQELAEEEQEQARERIK 698
>gi|33620716 retinoblastoma-binding protein 6 isoform 2 [Homo sapiens]
Length = 1758
Score = 72.8 bits (177), Expect = 4e-12
Identities = 183/916 (19%), Positives = 359/916 (39%), Gaps = 125/916 (13%)
Query: 625 RAGKKSVLSQGKTESESKNSHSKTSVEKNHVEKDKMNTLDILRME---TTERENP-EAET 680
R +K S+G E + S+ S E VE++K ++L +L T R+ P +AE+
Sbjct: 903 RKRRKGEESEGFLNPELLET-SRKSREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAES 961
Query: 681 VSVLGEKNCLQEGSQLKALRPVQVRGRLQKPKPNAGKAAERKEILIS-----QEEIGANV 735
++ + E + + +P + +G K K N G A +KE ++ QE++
Sbjct: 962 ITF----KSVSEKDKRERDKP-KAKGDKTKRK-NDGSAVSKKENIVKPAKGPQEKVDGER 1015
Query: 736 EKNENESC----ADRDTPQHMEDQSRKDFEEEDVIL-QPEKNDSFQNVQPDEPKVLNECL 790
E++ A +TP+ +S ++++ I P K S + E K + E
Sbjct: 1016 ERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEK 1075
Query: 791 SVQENNKANKLNQVPILRTRFQKP----KPNIGRGTGRREISSKEEVLEKILVSGEMAAA 846
++ +K K ++ + +KP KP +G R+ + ++ V + S +
Sbjct: 1076 VKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISK 1135
Query: 847 LRETVRLDTSPKEMVPAEINTKEMQSDLKETGRRAISPREKILDVIDDTIEMETGLKAMG 906
L T + SPK ++M+ D ++ R ++KI L A
Sbjct: 1136 LEVTEIVKPSPK---------RKMEPDTEKMDRTP--EKDKI------------SLSAPA 1172
Query: 907 REICLREKTPEVIDATEEIDKDLEEAGRREISPQKNGPEEVKPLGEVETDLKATGNESS- 965
++I L +T + I +TE I E + + E + K E+VK G+V + T SS
Sbjct: 1173 KKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVK--GKVRRKVTGTEGSSST 1230
Query: 966 -------------PREKTPEVTDATEEIDKNLEETGRRKISPRENG------PEEVKPVD 1006
P K+ E TD + K +EE +P E+ P+ D
Sbjct: 1231 LVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKD 1290
Query: 1007 EMET---DLNATGRESSPREKTPEVIDATEEID--LEETEREVSPQENGLEEVKPLGE-- 1059
+ E+ D+ +T SS + + + + + ++ E+E P E + K +
Sbjct: 1291 DFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEI 1350
Query: 1060 METDLKATGRD-SFPRGKTPEVIDAIEEIEIDLEETEREISPQ-ENGLEEVKPLGEMQTD 1117
++ ++K++ S +GKT + ++ E E + E+ + P+ E+ L+ + G ++
Sbjct: 1351 IQHEVKSSKNSASSEKGKTKDRDYSVLEKE-NPEKRKNSTQPEKESNLDRLNEQGNFKS- 1408
Query: 1118 LKATGREISPREKTPEVIDATEEIDKDLEETGRREISPEENGPEEVKPVDEMETDLKTTG 1177
L + +E +T + D+T R S ++ P K D + ++
Sbjct: 1409 LSQSSKEA----RTSDKHDST------------RASSNKDFTPNRDKKTDYDTREYSSSK 1452
Query: 1178 REGSSREKTREVIDAAEVIETDLEETEREISPQENGPEEVKPVGKMETDLKEIREEISQR 1237
R E TR + + S Q+N P E + + K T + R
Sbjct: 1453 RRDEKNELTRR--------KDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSR 1504
Query: 1238 EKVLAEFSAIREKEIDLKETGKRDIPIMEKVSGKMAVVEEMEADLKETGKENFRERGSEE 1297
++ + A + + +ET D + V E + + +G + E
Sbjct: 1505 DRKPHDHKATYDTKRPNEETKSVD---KNPCKDREKHVLEARNNKESSGNKLLYILNPPE 1561
Query: 1298 ICVTEEKVAELKQTGKTDISPRENELEETSTS----RQTDTHLMQSGSNDFSAVPSLDIQ 1353
V +E++ Q K+ + P+ + S R+TD + N+ + ++ ++
Sbjct: 1562 TQVEKEQITG--QIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVK 1619
Query: 1354 ------NISSEVLSMMHTPVEEKRNSEKEVSSHFSHFKISSQTHESDKTEVQGIQSPDVP 1407
NIS ++ + +E ++ V S +Q+H S SP
Sbjct: 1620 EEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISR----NQSHSSPSVSPSRSHSPSGS 1675
Query: 1408 EQFSDINLSKSLP-QEQKPLEIKPAPFVRSRFKRPKPNLARAALKRETTESEKYIYEKKS 1466
+ S + + S Q+ K + K + K+ K + A + E +S+K+ ++KK
Sbjct: 1676 QTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKK 1735
Query: 1467 ETKKMETIVMQENNEQ 1482
K + +E ++Q
Sbjct: 1736 SKKNKDKEKEKEKDDQ 1751
Score = 60.5 bits (145), Expect = 2e-08
Identities = 174/987 (17%), Positives = 356/987 (36%), Gaps = 129/987 (13%)
Query: 469 QDGANELGVNNLLENATVQA-GPSKGEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGI 527
+DG N+ E + A G KG KHK + + E EG + E + + ++ +
Sbjct: 871 RDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRKSRE-- 928
Query: 528 VGFASTEKVEKRTDPILSLSNQQDATSVATESSESSTSDLPSFEVGIRALCEVNNAEGSC 587
T E +TD + L ++ DAT V E ++ + S + + A+G
Sbjct: 929 ----PTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGD- 983
Query: 588 IEERNVDLKNNSLEIDQTENVKPMLRGRFQRPKPNLSRAGKKSVLSQGKTESESKNSHSK 647
KN+ + + EN+ +G ++ R+ + + E K ++K
Sbjct: 984 ----KTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTK 1039
Query: 648 TSVEKNHVEKDKMNTLDILRMETTERENPEAETVSVLGEKNCLQEGSQLKALRPVQVRGR 707
+S EK R ++ ET V EK +K+ + +
Sbjct: 1040 SSSSSQKDEK----ITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEK 1095
Query: 708 LQKP----KPNAGKAAERKEILISQEEIGANVEKNENESCADRDTPQHMEDQSRKDFEEE 763
+KP KP K +RK + E D+D S+ + E
Sbjct: 1096 AKKPNEKNKPLDNKGEKRK--------------RKTEEKGVDKDFESSSMKISKLEVTE- 1140
Query: 764 DVILQPEKNDSFQNVQPDEPKV----LNECLSVQENNKANKLNQVPILRTRFQKPKPNIG 819
I++P + ++PD K+ + +S+ K KLN+ + + N
Sbjct: 1141 --IVKPSPK---RKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTK 1195
Query: 820 RGTGRREISSKEEVLEKILVSGEMAAALRETVRLDTSPKEMVPAEINTKEMQSDLKETGR 879
+ + E +S + EK V G++ R+ + S +V + S ++++
Sbjct: 1196 EPSEKLESTSSKVKQEK--VKGKVR---RKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEE 1250
Query: 880 RAISPREKILDVIDDTIEMETGLKAMGREICLREKTPEVIDATEEIDKDLEEAGRREISP 939
+ + R VI E A ++ + + P+ ++ D + EE + P
Sbjct: 1251 KTDTKR----TVIKTMEEYNNDNTAPAEDVIIMIQVPQ--SKWDKDDFESEEEDVKSTQP 1304
Query: 940 QKNGPEEVKPLGEVETD----LKATGNESSPREKTPEVT-DATEEIDKNLEETGRRKISP 994
+ + + V T +K ES P EK + T D + EI ++ ++ + S
Sbjct: 1305 ISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASS 1364
Query: 995 RENGPEEVKPVDEMETDLNATGRESSPREKTPEVIDATEEIDLEETEREVSPQENGLEEV 1054
+ + + D + +E+ + K + +D + +E
Sbjct: 1365 EKGKTK--------DRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEA 1416
Query: 1055 KPLGEMETDLKATGRDSFPRGKTPEVIDAIEEIEIDLEETEREISPQENGLEEVKPLGEM 1114
+ + ++ ++ +D P D E + + E++ +++ K
Sbjct: 1417 RTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKD---- 1472
Query: 1115 QTDLKATGREISPREKTPEVIDATEEIDKDLEETGRREISPEENGP-EEVKPVDEMET-D 1172
A+G++ PRE ++DL + G + + P + KP D T D
Sbjct: 1473 ----SASGQKNKPRE------------ERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYD 1516
Query: 1173 LKTTGREGSS------REKTREVIDAAEVIETDLEETEREISPQENGPEEVKPVGKMETD 1226
K E S +++ + V++A E+ + ++P E E+ + G+++
Sbjct: 1517 TKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKS 1576
Query: 1227 LKEIREEISQREKVLAEFSAIREKEIDLKETGKRDIPIMEKVSGKMAVVEEMEADLKETG 1286
+ + ++S ++ ++ + RE + E + VS K EE ++ +
Sbjct: 1577 TVKPKPQLSHSSRLSSDLT--RETDEAAFEPDYNESDSESNVSVK---EEESSGNISKDL 1631
Query: 1287 KENFRERGSEEI---CVTEEKVAELKQTGKTDISPRENELEETSTSRQTDTHLMQSGSND 1343
K+ E+ E + V + ++ + +SP + S +R S S+
Sbjct: 1632 KDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTR--------SHSSS 1683
Query: 1344 FSAVPSLDIQNISSEVLSMMHTPVEEKRNSEKEVSSHFSHFKISS-QTHESDKTEVQGIQ 1402
S+ S D +K+ +KE H H K + H + E++ Q
Sbjct: 1684 ASSAESQD----------------SKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQ 1727
Query: 1403 SPDVPEQFSDINLSKSLPQEQKPLEIK 1429
++ S N K +E+ ++K
Sbjct: 1728 KHKHKKKKSKKNKDKEKEKEKDDQKVK 1754
Score = 42.4 bits (98), Expect = 0.006
Identities = 148/750 (19%), Positives = 267/750 (35%), Gaps = 132/750 (17%)
Query: 372 QKVLAEEEKRKQKSVKNHSLKEKKSTKPRKNVKVKKVACEGVNNDPDESMSSRISDTERS 431
+K+ K KS K H + TKP K KVKK
Sbjct: 1048 EKITGTPRKAHSKSAKEH-----QETKPVKEEKVKK------------------------ 1078
Query: 432 QKDAQTVEEESLTLSREDAE---QVALEVDLNQKKRRRKKQDGANELGVNNLLENATVQA 488
++ V+ E LT E A+ + +D +KR+RK + E GV+ E+++++
Sbjct: 1079 -DYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTE----EKGVDKDFESSSMKI 1133
Query: 489 GPSKGEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGIVGFASTEKVE--KRTDPILSL 546
SK E + ++P K + + T D I A +K++ + T +
Sbjct: 1134 --SKLE----VTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGS 1187
Query: 547 SNQQDATSVATESSESSTSDLPSFEVGIRALCEVNNAEGSCIEERNVDLKNNSLEIDQTE 606
+ T +E ES++S + +V + +V EGS +S +D T
Sbjct: 1188 TENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGS-----------SSTLVDYTS 1236
Query: 607 NVKPMLRGRFQRPKPNLSRAGKKSVLSQGKTESESKNSHSKTSVEKNHVEKDKMNTLDIL 666
G K K++V+ KT E N ++ + + + + + D
Sbjct: 1237 TSS---TGGSPVRKSEEKTDTKRTVI---KTMEEYNNDNTAPAEDVIIMIQVPQSKWDKD 1290
Query: 667 RMETTERENPEAETVSVLGEKNCLQEGSQLKALRPVQVRGRLQKPKPNAGKAAERKEILI 726
E+ E + + +S +G+ + + K V+ + +P K + I
Sbjct: 1291 DFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEI 1350
Query: 727 SQEEIGANVEKNENESCADRDTPQHMEDQSRKDFEEEDVILQPEKNDSFQNVQPDEPKVL 786
Q E+ ++ +E +D + ++ + + QPEK + + ++
Sbjct: 1351 IQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNST--QPEKESNLDRLN-EQGNFK 1407
Query: 787 NECLSVQENNKANKLNQVPILRTRFQKPKPNIGRGTGRREISSKEEVLEKILVSGEMAAA 846
+ S +E ++K + + P + RE SS + EK
Sbjct: 1408 SLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEK---------- 1457
Query: 847 LRETVRLDTSPKEMVPAEINTKEMQSDLKETGRRAISPREKILDVIDDTIEMETGLKAMG 906
E R SP K+ S K PRE+ D + TG
Sbjct: 1458 -NELTRRKDSPS-------RNKDSASGQKN------KPREE-----RDLPKKGTGDSKKS 1498
Query: 907 REICLREKTPEVIDATEEIDKDLEEAGRREISPQKNGPEEVKPLGEVETDLKATGNE--- 963
R++ P AT + + EE + +P K+ + V E + +++GN+
Sbjct: 1499 NSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVL---EARNNKESSGNKLLY 1555
Query: 964 -SSPREKTPEVTDATEEIDKNLEETGRRKISPRENGPEEVKPVDEMETDLNATGRESSPR 1022
+P E E T +IDK+ VKP + L+ + R SS
Sbjct: 1556 ILNPPETQVEKEQITGQIDKS-----------------TVKP----KPQLSHSSRLSS-- 1592
Query: 1023 EKTPEVIDATEEIDLEETEREVSPQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEVID 1082
+ T E +A E D E++ E ++E + G + DLK D K E +D
Sbjct: 1593 DLTRETDEAAFEPDYNESDSE---SNVSVKEEESSGNISKDLK----DKIVE-KAKESLD 1644
Query: 1083 AIEEIEIDLEETEREISPQENGLEEVKPLG 1112
+++ + + SP + P G
Sbjct: 1645 TAAVVQVGISRNQSHSSPSVSPSRSHSPSG 1674
Score = 40.0 bits (92), Expect = 0.030
Identities = 147/769 (19%), Positives = 280/769 (36%), Gaps = 118/769 (15%)
Query: 1132 PEVIDATEEIDK--DLEETGRREISPEENGPEEVKPVDEMETDLKTTGREGSSREKTREV 1189
P DAT D+ D E + +S E++ E KP + + D +GS+ K +
Sbjct: 944 PSRDDATPVRDEPMDAESITFKSVS-EKDKRERDKP--KAKGDKTKRKNDGSAVSKKENI 1000
Query: 1190 IDAAEVIETDLEETEREISPQENGPEEVKPVGKMETDLKEIREEISQREKVLAEFSAIRE 1249
+ A+ + ++ ERE SP+ P +K+ +EE + + + S+ ++
Sbjct: 1001 VKPAKGPQEKVDG-ERERSPRSEPP------------IKKAKEETPKTDNTKSSSSSQKD 1047
Query: 1250 KEIDLKETGKRDIPIMEKVSGKMAVVEEMEADLKE--TGKENFRERGSEEICVTEEKVAE 1307
++I TG K K A + +KE K+ ++ SE++ EEK +
Sbjct: 1048 EKI----TGTP-----RKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKK 1098
Query: 1308 LKQTGK---TDISPRENELEETSTSRQTDTHLMQSGSNDFSAVPSLDIQNISSEVLSMMH 1364
+ K R+ + EE + ++ M+ + L++ I
Sbjct: 1099 PNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMK--------ISKLEVTEIVKPSPKRKM 1150
Query: 1365 TPVEEK--RNSEKEVSSHFSHFKISSQTHESDKTEVQGIQSPDVPEQFSDINLSKSLPQE 1422
P EK R EK+ S + K E+ K I ++++
Sbjct: 1151 EPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKK----------------IGSTENISNT 1194
Query: 1423 QKPLEIKPAPFVRSRFKRPKPNLARAALKRETTESEKYIY--------------EKKSET 1468
++P E + + + ++ K + R E + S Y E+K++T
Sbjct: 1195 KEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDT 1254
Query: 1469 KKMETIVMQENNEQTDTLPSQHDEASLMISREKDTLGHRNEEAVILPCTQTERNLSPSNS 1528
K+ M+E N +T P++ + + + K E + TQ ++ S
Sbjct: 1255 KRTVIKTMEEYNND-NTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPAS 1313
Query: 1529 CEPKEESQSAPVQKNDSVVSVGTNNVNTFQQEMKESVIQ--------TARQVRGR----- 1575
++ + + K S + + F +++ +IQ +A +G+
Sbjct: 1314 VIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRD 1373
Query: 1576 ---LQRPRPNIRKTGQRQIVDKGEAKGIIKEGRTILPKDETEKKVLTVSNSQIETEIEVP 1632
L++ P RK + +K + E ++ K+ T S+ T
Sbjct: 1374 YSVLEKENPEKRKNSTQP--EKESNLDRLNEQGNFKSLSQSSKEART-SDKHDSTRASSN 1430
Query: 1633 SSAVPEHRMYENQSQVVLVENLHVNKTNETIRHENKPYVPSSAQMTRRKFQKAKPNLGRA 1692
P + + ++ NE R ++ P S QK KP R
Sbjct: 1431 KDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSP----SRNKDSASGQKNKPREERD 1486
Query: 1693 HSKKEEPVLEKVTTDQSKEGKPEDHLLQKGASNTQLLLKEKAELLTSLEVSARKDCVGSK 1752
KK +K + S++ KP DH K +T K E S++ + KD +
Sbjct: 1487 LPKKGTGDSKKSNSSPSRDRKPHDH---KATYDT----KRPNEETKSVDKNPCKD----R 1535
Query: 1753 ESALAKIDAELEEVGPSRRVGEETVGDNSPSSVVEEQ----YLNKLTSCPQPLNETSYSK 1808
E + + E G + N P + VE++ ++K T P+P S S+
Sbjct: 1536 EKHVLEARNNKESSG-----NKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHS-SR 1589
Query: 1809 IALD-GKTTISSTSEYERNRGERRSHKKFKPNVTRGRGSKRVRGKTSKK 1856
++ D + T + E + N + S+ K + G SK ++ K +K
Sbjct: 1590 LSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEK 1638
Score = 33.9 bits (76), Expect = 2.2
Identities = 84/452 (18%), Positives = 152/452 (33%), Gaps = 53/452 (11%)
Query: 1780 NSPSSVVEEQYLNKLTSCPQPLNETSYSKIALDGKTTISSTSEYERNRGERRSHKKFKPN 1839
N P E +Y N+ P P + +Y ++D + E R R ++K+
Sbjct: 751 NVPQGETEREYFNRYREVPPPYDMKAYYGRSVDFRDPFEKERYREWERKYREWYEKYYKG 810
Query: 1840 VTRGRGSKRVRGKTSKKEPRASKAMLVTLRASQEEDDDADDFESDYEEESYHLAPEEVNK 1899
G + R +++ + + + +R S +D+ S +
Sbjct: 811 YAAG---AQPRPSANRENFSPERFLPLNIRNSPFTRGRREDYVGGQSHRSRN-------- 859
Query: 1900 APVFVPVGLRSPEPVSA-----QIEETMEELEITVNVPDVGCIAVVEHELPNTDVTTEEM 1954
+G PE +SA Q + T + + + N P G + +
Sbjct: 860 ------IGSNYPEKLSARDGHNQKDNTKSKEKESENAPGDG-----KGNKHKKHRKRRKG 908
Query: 1955 KQEENLSVPFEMTTSEHIQDEPGTNDGSTEAAITLLTMGDLVLQSEISSEQGDVGVCIIP 2014
++ E P + TS ++ G + T++ L + D + + E D
Sbjct: 909 EESEGFLNPELLETSRKSREPTGVEENKTDSLFVLPSRDD---ATPVRDEPMDAESITFK 965
Query: 2015 HVHSKDK-SHIPSSLDNVNHKIVHECQELSSPVITTSPASFEENKIVLEEQSSREEISLM 2073
V KDK K ++ +S PA + K+ E + S +
Sbjct: 966 SVSEKDKRERDKPKAKGDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPI 1025
Query: 2074 EKVKENATPTRNTISKVTSNLRIRSRLAKPKPNLEKTLGTNRLDDYQEVSSLCVTKGAEM 2133
+K KE T NT S +S EK GT R + TK +
Sbjct: 1026 KKAKEETPKTDNTKSSSSSQ------------KDEKITGTPRKAHSKSAKEHQETKPVKE 1073
Query: 2134 ETQRETEKNASKATELENKNLGPVTTAENKDQSKLACVHGIKGTSISSEVNLTERNENQE 2193
E + +K+ SK + E + +++K G K + E + +++ E
Sbjct: 1074 E---KVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGV---DKDFE 1127
Query: 2194 ESSQEVHMLSVA----PVASSETGPCTLGLDR 2221
SS ++ L V P + P T +DR
Sbjct: 1128 SSSMKISKLEVTEIVKPSPKRKMEPDTEKMDR 1159
Score = 33.5 bits (75), Expect = 2.8
Identities = 64/363 (17%), Positives = 129/363 (35%), Gaps = 52/363 (14%)
Query: 51 TDVPTVDFGGAEPQEKAPRSSTEKTGGDNDVEESSRSSSTVSQRRKRISSTSSLVKSSVS 110
TD T ++ ++ +++ + K + + +S + + R + K S S
Sbjct: 1441 TDYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNS 1500
Query: 111 VPSESHP----LSTINQEAPQPTATSTKEKQPCSDRYRIYKAQKLREMLKEELRKEKKQW 166
PS +T + + P T + +K PC DR + +L+ KE
Sbjct: 1501 SPSRDRKPHDHKATYDTKRPNEE-TKSVDKNPCKDREK--------HVLEARNNKESSGN 1551
Query: 167 KNKYAINESQRPPDRSKMTMRDFIYYLPDNNPMTSSLEQEKKTEKPSTPVQTREQEGKST 226
K Y +N + ++ ++T + +K T KP + S
Sbjct: 1552 KLLYILNPPETQVEKEQITG-----------------QIDKSTVKPKPQL--------SH 1586
Query: 227 PNAEDNEMEEETDDGPLLVPRVKVAEDGSIILDEESLTVEVLRTKGPCVVEENDPIFERG 286
+ +++ ETD+ + + ++ + EE + + + +VE+ +
Sbjct: 1587 SSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTA 1646
Query: 287 STTTYSSFRKNYYSKPWSNKETDMFFLAISMVGTDFSMIGQLFPHRARIEIKNKFKREEK 346
+ R +S P + S G+ + K K K++EK
Sbjct: 1647 AVVQVGISRNQSHSSPSVSPSRSH-----SPSGSQTRSHSSSASSAESQDSKKKKKKKEK 1701
Query: 347 TNGWRIDKAFQEKRPFDFDFFAHLLQKV-LAEEEKRKQKSVKNHSLKEKKSTKPRKNVKV 405
+ K + K+ H +V L + +K K K K+ K+K+ K + + KV
Sbjct: 1702 KKHKKHKKHKKHKK--------HAGTEVELEKSQKHKHKKKKSKKNKDKEKEKEKDDQKV 1753
Query: 406 KKV 408
K V
Sbjct: 1754 KSV 1756
>gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo sapiens]
Length = 1792
Score = 72.8 bits (177), Expect = 4e-12
Identities = 183/916 (19%), Positives = 359/916 (39%), Gaps = 125/916 (13%)
Query: 625 RAGKKSVLSQGKTESESKNSHSKTSVEKNHVEKDKMNTLDILRME---TTERENP-EAET 680
R +K S+G E + S+ S E VE++K ++L +L T R+ P +AE+
Sbjct: 937 RKRRKGEESEGFLNPELLET-SRKSREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAES 995
Query: 681 VSVLGEKNCLQEGSQLKALRPVQVRGRLQKPKPNAGKAAERKEILIS-----QEEIGANV 735
++ + E + + +P + +G K K N G A +KE ++ QE++
Sbjct: 996 ITF----KSVSEKDKRERDKP-KAKGDKTKRK-NDGSAVSKKENIVKPAKGPQEKVDGER 1049
Query: 736 EKNENESC----ADRDTPQHMEDQSRKDFEEEDVIL-QPEKNDSFQNVQPDEPKVLNECL 790
E++ A +TP+ +S ++++ I P K S + E K + E
Sbjct: 1050 ERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEK 1109
Query: 791 SVQENNKANKLNQVPILRTRFQKP----KPNIGRGTGRREISSKEEVLEKILVSGEMAAA 846
++ +K K ++ + +KP KP +G R+ + ++ V + S +
Sbjct: 1110 VKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISK 1169
Query: 847 LRETVRLDTSPKEMVPAEINTKEMQSDLKETGRRAISPREKILDVIDDTIEMETGLKAMG 906
L T + SPK ++M+ D ++ R ++KI L A
Sbjct: 1170 LEVTEIVKPSPK---------RKMEPDTEKMDRTP--EKDKI------------SLSAPA 1206
Query: 907 REICLREKTPEVIDATEEIDKDLEEAGRREISPQKNGPEEVKPLGEVETDLKATGNESS- 965
++I L +T + I +TE I E + + E + K E+VK G+V + T SS
Sbjct: 1207 KKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVK--GKVRRKVTGTEGSSST 1264
Query: 966 -------------PREKTPEVTDATEEIDKNLEETGRRKISPRENG------PEEVKPVD 1006
P K+ E TD + K +EE +P E+ P+ D
Sbjct: 1265 LVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKD 1324
Query: 1007 EMET---DLNATGRESSPREKTPEVIDATEEID--LEETEREVSPQENGLEEVKPLGE-- 1059
+ E+ D+ +T SS + + + + + ++ E+E P E + K +
Sbjct: 1325 DFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEI 1384
Query: 1060 METDLKATGRD-SFPRGKTPEVIDAIEEIEIDLEETEREISPQ-ENGLEEVKPLGEMQTD 1117
++ ++K++ S +GKT + ++ E E + E+ + P+ E+ L+ + G ++
Sbjct: 1385 IQHEVKSSKNSASSEKGKTKDRDYSVLEKE-NPEKRKNSTQPEKESNLDRLNEQGNFKS- 1442
Query: 1118 LKATGREISPREKTPEVIDATEEIDKDLEETGRREISPEENGPEEVKPVDEMETDLKTTG 1177
L + +E +T + D+T R S ++ P K D + ++
Sbjct: 1443 LSQSSKEA----RTSDKHDST------------RASSNKDFTPNRDKKTDYDTREYSSSK 1486
Query: 1178 REGSSREKTREVIDAAEVIETDLEETEREISPQENGPEEVKPVGKMETDLKEIREEISQR 1237
R E TR + + S Q+N P E + + K T + R
Sbjct: 1487 RRDEKNELTRR--------KDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSR 1538
Query: 1238 EKVLAEFSAIREKEIDLKETGKRDIPIMEKVSGKMAVVEEMEADLKETGKENFRERGSEE 1297
++ + A + + +ET D + V E + + +G + E
Sbjct: 1539 DRKPHDHKATYDTKRPNEETKSVD---KNPCKDREKHVLEARNNKESSGNKLLYILNPPE 1595
Query: 1298 ICVTEEKVAELKQTGKTDISPRENELEETSTS----RQTDTHLMQSGSNDFSAVPSLDIQ 1353
V +E++ Q K+ + P+ + S R+TD + N+ + ++ ++
Sbjct: 1596 TQVEKEQITG--QIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVK 1653
Query: 1354 ------NISSEVLSMMHTPVEEKRNSEKEVSSHFSHFKISSQTHESDKTEVQGIQSPDVP 1407
NIS ++ + +E ++ V S +Q+H S SP
Sbjct: 1654 EEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISR----NQSHSSPSVSPSRSHSPSGS 1709
Query: 1408 EQFSDINLSKSLP-QEQKPLEIKPAPFVRSRFKRPKPNLARAALKRETTESEKYIYEKKS 1466
+ S + + S Q+ K + K + K+ K + A + E +S+K+ ++KK
Sbjct: 1710 QTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKK 1769
Query: 1467 ETKKMETIVMQENNEQ 1482
K + +E ++Q
Sbjct: 1770 SKKNKDKEKEKEKDDQ 1785
Score = 60.5 bits (145), Expect = 2e-08
Identities = 174/987 (17%), Positives = 356/987 (36%), Gaps = 129/987 (13%)
Query: 469 QDGANELGVNNLLENATVQA-GPSKGEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGI 527
+DG N+ E + A G KG KHK + + E EG + E + + ++ +
Sbjct: 905 RDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRKSRE-- 962
Query: 528 VGFASTEKVEKRTDPILSLSNQQDATSVATESSESSTSDLPSFEVGIRALCEVNNAEGSC 587
T E +TD + L ++ DAT V E ++ + S + + A+G
Sbjct: 963 ----PTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGD- 1017
Query: 588 IEERNVDLKNNSLEIDQTENVKPMLRGRFQRPKPNLSRAGKKSVLSQGKTESESKNSHSK 647
KN+ + + EN+ +G ++ R+ + + E K ++K
Sbjct: 1018 ----KTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTK 1073
Query: 648 TSVEKNHVEKDKMNTLDILRMETTERENPEAETVSVLGEKNCLQEGSQLKALRPVQVRGR 707
+S EK R ++ ET V EK +K+ + +
Sbjct: 1074 SSSSSQKDEK----ITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEK 1129
Query: 708 LQKP----KPNAGKAAERKEILISQEEIGANVEKNENESCADRDTPQHMEDQSRKDFEEE 763
+KP KP K +RK + E D+D S+ + E
Sbjct: 1130 AKKPNEKNKPLDNKGEKRK--------------RKTEEKGVDKDFESSSMKISKLEVTE- 1174
Query: 764 DVILQPEKNDSFQNVQPDEPKV----LNECLSVQENNKANKLNQVPILRTRFQKPKPNIG 819
I++P + ++PD K+ + +S+ K KLN+ + + N
Sbjct: 1175 --IVKPSPK---RKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTK 1229
Query: 820 RGTGRREISSKEEVLEKILVSGEMAAALRETVRLDTSPKEMVPAEINTKEMQSDLKETGR 879
+ + E +S + EK V G++ R+ + S +V + S ++++
Sbjct: 1230 EPSEKLESTSSKVKQEK--VKGKVR---RKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEE 1284
Query: 880 RAISPREKILDVIDDTIEMETGLKAMGREICLREKTPEVIDATEEIDKDLEEAGRREISP 939
+ + R VI E A ++ + + P+ ++ D + EE + P
Sbjct: 1285 KTDTKR----TVIKTMEEYNNDNTAPAEDVIIMIQVPQ--SKWDKDDFESEEEDVKSTQP 1338
Query: 940 QKNGPEEVKPLGEVETD----LKATGNESSPREKTPEVT-DATEEIDKNLEETGRRKISP 994
+ + + V T +K ES P EK + T D + EI ++ ++ + S
Sbjct: 1339 ISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASS 1398
Query: 995 RENGPEEVKPVDEMETDLNATGRESSPREKTPEVIDATEEIDLEETEREVSPQENGLEEV 1054
+ + + D + +E+ + K + +D + +E
Sbjct: 1399 EKGKTK--------DRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEA 1450
Query: 1055 KPLGEMETDLKATGRDSFPRGKTPEVIDAIEEIEIDLEETEREISPQENGLEEVKPLGEM 1114
+ + ++ ++ +D P D E + + E++ +++ K
Sbjct: 1451 RTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKD---- 1506
Query: 1115 QTDLKATGREISPREKTPEVIDATEEIDKDLEETGRREISPEENGP-EEVKPVDEMET-D 1172
A+G++ PRE ++DL + G + + P + KP D T D
Sbjct: 1507 ----SASGQKNKPRE------------ERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYD 1550
Query: 1173 LKTTGREGSS------REKTREVIDAAEVIETDLEETEREISPQENGPEEVKPVGKMETD 1226
K E S +++ + V++A E+ + ++P E E+ + G+++
Sbjct: 1551 TKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKS 1610
Query: 1227 LKEIREEISQREKVLAEFSAIREKEIDLKETGKRDIPIMEKVSGKMAVVEEMEADLKETG 1286
+ + ++S ++ ++ + RE + E + VS K EE ++ +
Sbjct: 1611 TVKPKPQLSHSSRLSSDLT--RETDEAAFEPDYNESDSESNVSVK---EEESSGNISKDL 1665
Query: 1287 KENFRERGSEEI---CVTEEKVAELKQTGKTDISPRENELEETSTSRQTDTHLMQSGSND 1343
K+ E+ E + V + ++ + +SP + S +R S S+
Sbjct: 1666 KDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTR--------SHSSS 1717
Query: 1344 FSAVPSLDIQNISSEVLSMMHTPVEEKRNSEKEVSSHFSHFKISS-QTHESDKTEVQGIQ 1402
S+ S D +K+ +KE H H K + H + E++ Q
Sbjct: 1718 ASSAESQD----------------SKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQ 1761
Query: 1403 SPDVPEQFSDINLSKSLPQEQKPLEIK 1429
++ S N K +E+ ++K
Sbjct: 1762 KHKHKKKKSKKNKDKEKEKEKDDQKVK 1788
Score = 42.4 bits (98), Expect = 0.006
Identities = 148/750 (19%), Positives = 267/750 (35%), Gaps = 132/750 (17%)
Query: 372 QKVLAEEEKRKQKSVKNHSLKEKKSTKPRKNVKVKKVACEGVNNDPDESMSSRISDTERS 431
+K+ K KS K H + TKP K KVKK
Sbjct: 1082 EKITGTPRKAHSKSAKEH-----QETKPVKEEKVKK------------------------ 1112
Query: 432 QKDAQTVEEESLTLSREDAE---QVALEVDLNQKKRRRKKQDGANELGVNNLLENATVQA 488
++ V+ E LT E A+ + +D +KR+RK + E GV+ E+++++
Sbjct: 1113 -DYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTE----EKGVDKDFESSSMKI 1167
Query: 489 GPSKGEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGIVGFASTEKVE--KRTDPILSL 546
SK E + ++P K + + T D I A +K++ + T +
Sbjct: 1168 --SKLE----VTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGS 1221
Query: 547 SNQQDATSVATESSESSTSDLPSFEVGIRALCEVNNAEGSCIEERNVDLKNNSLEIDQTE 606
+ T +E ES++S + +V + +V EGS +S +D T
Sbjct: 1222 TENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGS-----------SSTLVDYTS 1270
Query: 607 NVKPMLRGRFQRPKPNLSRAGKKSVLSQGKTESESKNSHSKTSVEKNHVEKDKMNTLDIL 666
G K K++V+ KT E N ++ + + + + + D
Sbjct: 1271 TSS---TGGSPVRKSEEKTDTKRTVI---KTMEEYNNDNTAPAEDVIIMIQVPQSKWDKD 1324
Query: 667 RMETTERENPEAETVSVLGEKNCLQEGSQLKALRPVQVRGRLQKPKPNAGKAAERKEILI 726
E+ E + + +S +G+ + + K V+ + +P K + I
Sbjct: 1325 DFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEI 1384
Query: 727 SQEEIGANVEKNENESCADRDTPQHMEDQSRKDFEEEDVILQPEKNDSFQNVQPDEPKVL 786
Q E+ ++ +E +D + ++ + + QPEK + + ++
Sbjct: 1385 IQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNST--QPEKESNLDRLN-EQGNFK 1441
Query: 787 NECLSVQENNKANKLNQVPILRTRFQKPKPNIGRGTGRREISSKEEVLEKILVSGEMAAA 846
+ S +E ++K + + P + RE SS + EK
Sbjct: 1442 SLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEK---------- 1491
Query: 847 LRETVRLDTSPKEMVPAEINTKEMQSDLKETGRRAISPREKILDVIDDTIEMETGLKAMG 906
E R SP K+ S K PRE+ D + TG
Sbjct: 1492 -NELTRRKDSPS-------RNKDSASGQKN------KPREE-----RDLPKKGTGDSKKS 1532
Query: 907 REICLREKTPEVIDATEEIDKDLEEAGRREISPQKNGPEEVKPLGEVETDLKATGNE--- 963
R++ P AT + + EE + +P K+ + V E + +++GN+
Sbjct: 1533 NSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVL---EARNNKESSGNKLLY 1589
Query: 964 -SSPREKTPEVTDATEEIDKNLEETGRRKISPRENGPEEVKPVDEMETDLNATGRESSPR 1022
+P E E T +IDK+ VKP + L+ + R SS
Sbjct: 1590 ILNPPETQVEKEQITGQIDKS-----------------TVKP----KPQLSHSSRLSS-- 1626
Query: 1023 EKTPEVIDATEEIDLEETEREVSPQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEVID 1082
+ T E +A E D E++ E ++E + G + DLK D K E +D
Sbjct: 1627 DLTRETDEAAFEPDYNESDSE---SNVSVKEEESSGNISKDLK----DKIVE-KAKESLD 1678
Query: 1083 AIEEIEIDLEETEREISPQENGLEEVKPLG 1112
+++ + + SP + P G
Sbjct: 1679 TAAVVQVGISRNQSHSSPSVSPSRSHSPSG 1708
Score = 40.0 bits (92), Expect = 0.030
Identities = 147/769 (19%), Positives = 280/769 (36%), Gaps = 118/769 (15%)
Query: 1132 PEVIDATEEIDK--DLEETGRREISPEENGPEEVKPVDEMETDLKTTGREGSSREKTREV 1189
P DAT D+ D E + +S E++ E KP + + D +GS+ K +
Sbjct: 978 PSRDDATPVRDEPMDAESITFKSVS-EKDKRERDKP--KAKGDKTKRKNDGSAVSKKENI 1034
Query: 1190 IDAAEVIETDLEETEREISPQENGPEEVKPVGKMETDLKEIREEISQREKVLAEFSAIRE 1249
+ A+ + ++ ERE SP+ P +K+ +EE + + + S+ ++
Sbjct: 1035 VKPAKGPQEKVDG-ERERSPRSEPP------------IKKAKEETPKTDNTKSSSSSQKD 1081
Query: 1250 KEIDLKETGKRDIPIMEKVSGKMAVVEEMEADLKE--TGKENFRERGSEEICVTEEKVAE 1307
++I TG K K A + +KE K+ ++ SE++ EEK +
Sbjct: 1082 EKI----TGTP-----RKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKK 1132
Query: 1308 LKQTGK---TDISPRENELEETSTSRQTDTHLMQSGSNDFSAVPSLDIQNISSEVLSMMH 1364
+ K R+ + EE + ++ M+ + L++ I
Sbjct: 1133 PNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMK--------ISKLEVTEIVKPSPKRKM 1184
Query: 1365 TPVEEK--RNSEKEVSSHFSHFKISSQTHESDKTEVQGIQSPDVPEQFSDINLSKSLPQE 1422
P EK R EK+ S + K E+ K I ++++
Sbjct: 1185 EPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKK----------------IGSTENISNT 1228
Query: 1423 QKPLEIKPAPFVRSRFKRPKPNLARAALKRETTESEKYIY--------------EKKSET 1468
++P E + + + ++ K + R E + S Y E+K++T
Sbjct: 1229 KEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDT 1288
Query: 1469 KKMETIVMQENNEQTDTLPSQHDEASLMISREKDTLGHRNEEAVILPCTQTERNLSPSNS 1528
K+ M+E N +T P++ + + + K E + TQ ++ S
Sbjct: 1289 KRTVIKTMEEYNND-NTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPAS 1347
Query: 1529 CEPKEESQSAPVQKNDSVVSVGTNNVNTFQQEMKESVIQ--------TARQVRGR----- 1575
++ + + K S + + F +++ +IQ +A +G+
Sbjct: 1348 VIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRD 1407
Query: 1576 ---LQRPRPNIRKTGQRQIVDKGEAKGIIKEGRTILPKDETEKKVLTVSNSQIETEIEVP 1632
L++ P RK + +K + E ++ K+ T S+ T
Sbjct: 1408 YSVLEKENPEKRKNSTQP--EKESNLDRLNEQGNFKSLSQSSKEART-SDKHDSTRASSN 1464
Query: 1633 SSAVPEHRMYENQSQVVLVENLHVNKTNETIRHENKPYVPSSAQMTRRKFQKAKPNLGRA 1692
P + + ++ NE R ++ P S QK KP R
Sbjct: 1465 KDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSP----SRNKDSASGQKNKPREERD 1520
Query: 1693 HSKKEEPVLEKVTTDQSKEGKPEDHLLQKGASNTQLLLKEKAELLTSLEVSARKDCVGSK 1752
KK +K + S++ KP DH K +T K E S++ + KD +
Sbjct: 1521 LPKKGTGDSKKSNSSPSRDRKPHDH---KATYDT----KRPNEETKSVDKNPCKD----R 1569
Query: 1753 ESALAKIDAELEEVGPSRRVGEETVGDNSPSSVVEEQ----YLNKLTSCPQPLNETSYSK 1808
E + + E G + N P + VE++ ++K T P+P S S+
Sbjct: 1570 EKHVLEARNNKESSG-----NKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHS-SR 1623
Query: 1809 IALD-GKTTISSTSEYERNRGERRSHKKFKPNVTRGRGSKRVRGKTSKK 1856
++ D + T + E + N + S+ K + G SK ++ K +K
Sbjct: 1624 LSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEK 1672
Score = 33.9 bits (76), Expect = 2.2
Identities = 84/452 (18%), Positives = 152/452 (33%), Gaps = 53/452 (11%)
Query: 1780 NSPSSVVEEQYLNKLTSCPQPLNETSYSKIALDGKTTISSTSEYERNRGERRSHKKFKPN 1839
N P E +Y N+ P P + +Y ++D + E R R ++K+
Sbjct: 785 NVPQGETEREYFNRYREVPPPYDMKAYYGRSVDFRDPFEKERYREWERKYREWYEKYYKG 844
Query: 1840 VTRGRGSKRVRGKTSKKEPRASKAMLVTLRASQEEDDDADDFESDYEEESYHLAPEEVNK 1899
G + R +++ + + + +R S +D+ S +
Sbjct: 845 YAAG---AQPRPSANRENFSPERFLPLNIRNSPFTRGRREDYVGGQSHRSRN-------- 893
Query: 1900 APVFVPVGLRSPEPVSA-----QIEETMEELEITVNVPDVGCIAVVEHELPNTDVTTEEM 1954
+G PE +SA Q + T + + + N P G + +
Sbjct: 894 ------IGSNYPEKLSARDGHNQKDNTKSKEKESENAPGDG-----KGNKHKKHRKRRKG 942
Query: 1955 KQEENLSVPFEMTTSEHIQDEPGTNDGSTEAAITLLTMGDLVLQSEISSEQGDVGVCIIP 2014
++ E P + TS ++ G + T++ L + D + + E D
Sbjct: 943 EESEGFLNPELLETSRKSREPTGVEENKTDSLFVLPSRDD---ATPVRDEPMDAESITFK 999
Query: 2015 HVHSKDK-SHIPSSLDNVNHKIVHECQELSSPVITTSPASFEENKIVLEEQSSREEISLM 2073
V KDK K ++ +S PA + K+ E + S +
Sbjct: 1000 SVSEKDKRERDKPKAKGDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPI 1059
Query: 2074 EKVKENATPTRNTISKVTSNLRIRSRLAKPKPNLEKTLGTNRLDDYQEVSSLCVTKGAEM 2133
+K KE T NT S +S EK GT R + TK +
Sbjct: 1060 KKAKEETPKTDNTKSSSSSQ------------KDEKITGTPRKAHSKSAKEHQETKPVKE 1107
Query: 2134 ETQRETEKNASKATELENKNLGPVTTAENKDQSKLACVHGIKGTSISSEVNLTERNENQE 2193
E + +K+ SK + E + +++K G K + E + +++ E
Sbjct: 1108 E---KVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGV---DKDFE 1161
Query: 2194 ESSQEVHMLSVA----PVASSETGPCTLGLDR 2221
SS ++ L V P + P T +DR
Sbjct: 1162 SSSMKISKLEVTEIVKPSPKRKMEPDTEKMDR 1193
Score = 33.5 bits (75), Expect = 2.8
Identities = 64/363 (17%), Positives = 129/363 (35%), Gaps = 52/363 (14%)
Query: 51 TDVPTVDFGGAEPQEKAPRSSTEKTGGDNDVEESSRSSSTVSQRRKRISSTSSLVKSSVS 110
TD T ++ ++ +++ + K + + +S + + R + K S S
Sbjct: 1475 TDYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNS 1534
Query: 111 VPSESHP----LSTINQEAPQPTATSTKEKQPCSDRYRIYKAQKLREMLKEELRKEKKQW 166
PS +T + + P T + +K PC DR + +L+ KE
Sbjct: 1535 SPSRDRKPHDHKATYDTKRPNEE-TKSVDKNPCKDREK--------HVLEARNNKESSGN 1585
Query: 167 KNKYAINESQRPPDRSKMTMRDFIYYLPDNNPMTSSLEQEKKTEKPSTPVQTREQEGKST 226
K Y +N + ++ ++T + +K T KP + S
Sbjct: 1586 KLLYILNPPETQVEKEQITG-----------------QIDKSTVKPKPQL--------SH 1620
Query: 227 PNAEDNEMEEETDDGPLLVPRVKVAEDGSIILDEESLTVEVLRTKGPCVVEENDPIFERG 286
+ +++ ETD+ + + ++ + EE + + + +VE+ +
Sbjct: 1621 SSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTA 1680
Query: 287 STTTYSSFRKNYYSKPWSNKETDMFFLAISMVGTDFSMIGQLFPHRARIEIKNKFKREEK 346
+ R +S P + S G+ + K K K++EK
Sbjct: 1681 AVVQVGISRNQSHSSPSVSPSRSH-----SPSGSQTRSHSSSASSAESQDSKKKKKKKEK 1735
Query: 347 TNGWRIDKAFQEKRPFDFDFFAHLLQKV-LAEEEKRKQKSVKNHSLKEKKSTKPRKNVKV 405
+ K + K+ H +V L + +K K K K+ K+K+ K + + KV
Sbjct: 1736 KKHKKHKKHKKHKK--------HAGTEVELEKSQKHKHKKKKSKKNKDKEKEKEKDDQKV 1787
Query: 406 KKV 408
K V
Sbjct: 1788 KSV 1790
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.305 0.124 0.334
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 103,024,207
Number of Sequences: 37866
Number of extensions: 5241721
Number of successful extensions: 23838
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 52
Number of HSP's successfully gapped in prelim test: 998
Number of HSP's that attempted gapping in prelim test: 17696
Number of HSP's gapped (non-prelim): 6203
length of query: 2624
length of database: 18,247,518
effective HSP length: 119
effective length of query: 2505
effective length of database: 13,741,464
effective search space: 34422367320
effective search space used: 34422367320
T: 11
A: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.9 bits)
S2: 71 (32.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.